WorldWideScience

Sample records for biologics license applications

  1. 9 CFR 102.3 - License applications.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL... License shall be accompanied by an application for one or more U.S. Veterinary Biological Product Licenses... time. (b) U.S. Veterinary Biological Product License. (1) The licensee of each establishment...

  2. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  3. Support for the revocation of general safety test regulations in biologics license applications.

    Science.gov (United States)

    Evans, Dana M; Thorn, Jennifer M; Arch-Douglas, Katherine; Sperry, Justin B; Thompson, Bruce; Davis, Heather L; McCluskie, Michael J

    2016-05-01

    The United States Food and Drug Administration recently removed the requirement for a General Safety Test (GST) for biologics in the Code of Federal Regulations (21 CFR 610.11). The GST, as well as abnormal toxicity (European Pharmacopeia) and innocuity tests (World Health Organization), were designed to test for extraneous toxic contaminants on each product lot intended for human use. Tests require one-week observations for general health and weight following injection of specified volumes of product batches into guinea pigs and mice. At the volumes specified, dose-related toxicity may result when the product is pharmacologically active in rodents. With vaccines, required doses may be > 3 logs higher than intended human dose on a weight-adjusted basis and if an immune modulatory adjuvant is included, systemic immune hyperactivation may cause toxicity. Herein, using the CpG/alum adjuvant combination we evaluated the different test protocols and showed their unsuitability for this adjuvant combination. PMID:26996102

  4. 10 CFR 40.31 - Application for specific licenses.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Application for specific licenses. 40.31 Section 40.31 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL License Applications § 40.31 Application for specific licenses. (a) A person may file an application for specific license on NRC Form...

  5. 75 FR 53696 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-01

    ...), Theodore Green, Stockholder. Application Type: New NVO & OFF License. Aventura Logistics, Inc. (NVO & OFF.../ Secretary/Director (Qualifying Individual), Application Type: New NVO & OFF License. Cargo Express Logistics...: New NVO License. Everplus Logistics Inc. (NVO & OFF), 3 University Plaza, Hackensack, NJ...

  6. 77 FR 60434 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-03

    ... Type: New OFF License. Farkas Worldwide Shipping Inc. (NVO), 1420 W. Flager Street, Miami, FL 33135, Officers: Heather R. Farkas, President (QI), Maria A. Farkas, Secretary, Application Type: New NVO License... License. Mota Import Export LLC dba MTI Mota Import Export Cargo Express (NVO), 175 Smith Street,...

  7. 78 FR 69852 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-21

    ... Proprietor (QI), Application Type: Trade Name Change to Blue Ocean Express. United Harbour Logistics LLC (NVO... Ocean Transportation Intermediary License Applicants The Commission gives notice that the following applicants have filed an application for an Ocean Transportation Intermediary (OTI) license as a...

  8. 76 FR 554 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-01-05

    .... Officers: Jerry Wang, Vice President (Qualifying Individual), Loong H. Chang, President/Director... Raymond, CEO. Application Type: New NVO & OFF License. Toshiba Logistics America, Inc. (NVO & OFF),...

  9. 75 FR 34139 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-06-16

    ... Avenue Ct., Miami, FL 33186, Officers: Alberto E. Puentes, President (Qualifying Individual), Denise M. Puentes, Vice President/Secretary, Application Type: New OFF License. Science Logistics Corp. (OFF &...

  10. 78 FR 55698 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-11

    ... Type: New NVO License. Trans-Net, Inc. dba Hospitality Logistics International dba Trans-Net (NVO & OFF..., Secretary, Application Type: Delete Trade Name Hospitality Logistics International. Transtoria...

  11. 77 FR 70162 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-23

    ..., Application Type: Name Change to Midrex Global Logistics, Inc. dba Triangle Shipping Lines. Green World Export..., Application Type: New NVO License. Kaizen Logistics Corp (NVO & OFF), 1925 NW. 108th Avenue, Miami, FL 33172..., President (QI), Marilena Pertuz, Secretary, Application Type: License Transfer to MIA Logistics...

  12. 76 FR 22104 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-20

    ... Individual), Application Type: New NVO & OFF License Kinetix International Logistics, LLC (OFF), 5400 Shawnee..., Application Type: Add NVO Service ADM Logistics, Inc. (NVO & OFF), 4666 Faries Parkway, Decatur, IL 62526..., Application Type: New NVO & OFF License Amass International Group (New York) Inc. (NVO), Cargo Bldg. 75,...

  13. 78 FR 3424 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-01-16

    ... Ocean Transportation Intermediary License Applicants The Commission gives notice that the following applicants have filed an application for an Ocean Transportation Intermediary (OTI) license as a Non-Vessel-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF) pursuant to section 19 of the...

  14. 77 FR 59193 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-09-26

    .... CTS Global Logistics (Georgia) Inc. dba CTS Global Supply Chain Solutions (NVO & OFF), 5192 Southridge... Ocean Transportation Intermediary License Applicants The Commission gives notice that the following applicants have filed an application for an Ocean Transportation Intermediary (OTI) license as a...

  15. 9 CFR 102.5 - U.S. Veterinary Biological Product License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biological Product..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL PRODUCTS § 102.5 U.S. Veterinary Biological Product License. (a) Authorization to produce...

  16. 21 CFR 310.4 - Biologics; products subject to license control.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Biologics; products subject to license control. 310.4 Section 310.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... to license control. (a) If a drug has an approved license under section 351 of the Public...

  17. 77 FR 3773 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-01-25

    ... Ocean Transportation Intermediary License; Applicants Notice is hereby given that the following...-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF)--Ocean Transportation Intermediary (OTI...). Application Type: New OFF License. Kamino International Transport, Inc. dba Kamino Ocean Line (NVO &...

  18. 76 FR 10593 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-25

    ..., Application Type: QI Change. GC Logistics, Inc. (NVO), 79301 Country Club Drive, 104, Bermuda Dunes, CA 92203..., Application Type: New NVO License. KCTC International (America), Inc. dba World Bridge Line dba Green Shipping...: New NVO License. Pegasus3 Worldwide Logistics, LLC (NVO & OFF), 59 Grove Street, Stoughton, MA...

  19. 76 FR 70145 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-10

    ... Individual), Roza M. Castro, Manager. Application Type: New NVO License. Green Line Shipping & Logistics... Logistics Inc. (NVO), 144-54 156th Street, Jamaica, NY 11434. Officers: Victor Leung, Secretary (Qualifying... Individual), Jose F. Rodriguez, President. Application Type: New NVO License. Yes Logistics Corporation...

  20. 75 FR 40837 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-14

    ...), Virgil Hale, President, Application Type: New OFF License. AFL International Logistics Group LLC (NVO..., Director, Application Type: New OFF License. Direct Service Inc. dba Tiger Freight International... Name Change. Jupiter Airline Services, Inc. dba Mercury Logistics (NVO), 5456 McConnell Avenue,...

  1. 75 FR 39529 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-09

    ... & NVO License Blue Ocean Freight, Inc. dba Seaship Line (OFF & NVO), 250 Valley Street, 2F, Providence..., Secretary, Application Type: Add NVO Service and Trade Name Change Blue Ocean Shipping, Inc. dba Advanced... Ocean Transportation Intermediary License Applicants Notice is hereby given that the...

  2. 77 FR 20398 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-04-04

    ... Individual), Christopher J. Alf, Chairman/CEO, Application Type: New OFF License. Novargo Inc. (NVO), 38..., President/CEO, Application Type: New NVO & OFF License. Lars Courier, Inc. dba Lars International Freight...: Mark Bongean, Vice President (Operations), (Qualifying Individual), Sebastian Tshackert,...

  3. LTO License Application Project NPP Borssele

    International Nuclear Information System (INIS)

    Borssele NPP plans to extend its operating life with 20 years until 2034. Borssele has started the project LTO 'bewijsvoering' (LTO 'Justification') in order to meet the requirements of the Dutch regulator. The outline of the project is based on IAEA safety guide 57 'Safe Long Term Operation of Nuclear Power Plants'. This paper describes the contents and coherence of the different parts in the project and how these respond to the IAEA guidelines on LTO. The goal of the project LTO 'bewijsvoering' is to ensure that safety and safety relevant systems, structures and components continue to perform their intended functions during long term operation. The outcome of the project LTO 'bewijsvoering' will be used for a license change application and this will be submitted to the Dutch regulator KFD for approval of prolonged operation of Borssele NPP after 2013. (author)

  4. 75 FR 4560 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-01-28

    ... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to section...-Operating Common Carrier--Ocean Transportation Intermediary Applicants: Doma Consolidating Inc. dba...

  5. 76 FR 12962 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-03-09

    .../Director, Application Type: New NVO & OFF License. ICT International Cargo Transport (USA) Inc. (NVO & OFF..., President, ] Application Type: QI Change and Trade Name Change. Sola Transport Agency, Inc. (NVO),...

  6. 75 FR 52343 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-25

    ...: Xiao Chun Li, Vice President (Qualifying Individual), Yan Yang, CEO, Application Type: New NVO & OFF..., Chairman/Director, Application Type: New NVO License, United Marine Lines, L.L.C. (NVO), 201 Sevilla...

  7. 77 FR 45610 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-08-01

    ... President, Application Type: New NVO License. Aequus Worldwide Logistics Inc. (NVO), 319 E. Butterfield Road... Freight, Inc. FGN Global Logistics, Inc. (NVO & OFF), 4770 Highway 165, Meggett, SC 29449, Officers: Hugh... NVO & OFF License. Green Shipping, Inc. (NVO & OFF), 16012 S. Western Avenue 302, Gardena, CA...

  8. 75 FR 72824 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-26

    ... License. ITL USA Inc. dba International Transport & Logistics (ITL) USA Inc. (NVO & OFF), 1200 Route 22...), Bong K. Ji, President/CEO/Director, Application Type: New NVO License. Kinetix International Logistics.... Porras dba RA International (NVO & OFF), 1900 Los Alamitos Drive, Placentia, CA 92870, Officer: Arlette...

  9. NUCLEAR SAFETY DESIGN BASES FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-03-08

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111 [DIRS 156605] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113 [DIRS 156605] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  10. Nuclear Safety Design Base for License Application

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-09-29

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111(b) [DIRS 173273] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113(b) and (c) [DIRS 173273] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  11. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-02-17

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified.

  12. 78 FR 21365 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-10

    ... Officer (QI), Rosemary Myers, CEO, Application Type: New NVO & OFF License. Full Hull Logistics, LLC (NVO... 30096, Officers: Christopher J. Reilly, Vice President (QI), Neal Baines, Chairman of the...

  13. 75 FR 80499 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-12-22

    ...). Application Type: New OFF License. New Vista International LLC (NVO & OFF), 14939 Sugar Mist Lane, Sugar Land.... (NVO), 16801 Gale Avenue, Suite D, City of Industry, CA 91745. Officer: Leslie W. Fung,...

  14. Requirements for Foreign and Domestic Establishment Registration and Listing for Human Drugs, Including Drugs That Are Regulated Under a Biologics License Application, and Animal Drugs. Final rule.

    Science.gov (United States)

    2016-08-31

    The Food and Drug Administration (FDA) is amending its regulations governing drug establishment registration and drug listing. These amendments reorganize, modify, and clarify current regulations concerning who must register establishments and list human drugs, human drugs that are also biological products, and animal drugs. The final rule requires electronic submission, unless waived in certain circumstances, of registration and listing information. This rulemaking pertains to finished drug products and to active pharmaceutical ingredients (APIs) alone or together with one or more other ingredients. The final rule describes how and when owners or operators of establishments at which drugs are manufactured or processed must register their establishments with FDA and list the drugs they manufacture or process. In addition, the rule makes certain changes to the National Drug Code (NDC) system. We are taking this action to improve management of drug establishment registration and drug listing requirements and make these processes more efficient and effective for industry and for us. This action also supports implementation of the electronic prescribing provisions of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA) and the availability of current drug labeling information through DailyMed, a computerized repository of drug information maintained by the National Library of Medicine. PMID:27580511

  15. 78 FR 14792 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-07

    ... 91733. Officers: Alex C. Huang, CEO (QI); Wei Zheng, Shareholder. Application Type: New NVO & OFF.... Officers: Richard L. Giovannone, President (QI); Miranda L. Lou, Chairman. Application Type: QI Change.... Zavaleta, Secretary (QI); Patricia A. Whaley, CEO. Application Type: New NVO & OFF License Triple...

  16. 77 FR 37044 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-20

    ..., Chairman/CEO (Qualifying Individual), Application Type: License Transfer. Bayanihan Cargo International Inc.../CEO/Secretary/CFO (Qualifying Individual), Application Type: Trade Name Change. Aqua Gulf Transport... President (Qualifying Individual), Tae Soo Kim, President/CEO/Sec/Treasurer/CFO, Application Type: New...

  17. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    Energy Technology Data Exchange (ETDEWEB)

    Uleck, R.B.; DeFino, C.V. [Nuclear Regulatory Commission, Washington, DC (United States)

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health and safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.

  18. 10 CFR 72.16 - Filing of application for specific license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Filing of application for specific license. 72.16 Section 72.16 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT... application for a license or an amendment to a license for an MRS, the Director, Office of Nuclear...

  19. 76 FR 74060 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-30

    ..., Application Type: New NVO License. ASF Advantage, L.L.C. (NVO & OFF), 330 Marshall Street, 400, Shreveport, LA..., Application Type: QI Change. Encargo Export Corporation dba Encargo Logistics, dba Encargo Lines (NVO & OFF..., Inc. dba Yacht Exports (NVO), 5337 Orange Drive, Davie, FL 33314; Officer: Alon Ezra,...

  20. 75 FR 48686 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-11

    .... Green, Vice President Logistics Services (Qualifying Individual), John James, CEO, Application Type: New... Individual), Rodolfo Joffroy, President, Application Type: New NVO License. Maritime and Intermodal Logistics.... dba Rado Logistics (NVO & OFF), 2251 Sylvan Road, Suite C, East Point, GA 30344, Officers:...

  1. 77 FR 30530 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-23

    .... Piper, Member/President/CEO (Qualifying Individual), Application Type: New NVO License. Global Wine... NVO Service/Trade Name Change. M & D Global Logistics, Inc. (NVO & OFF), 2211 S. Hacienda Blvd., Suite...), Jun (Alex) Zhong, Secretary, Application Type: Add OFF Service. Metro Freight Services, Inc....

  2. 76 FR 31962 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-06-02

    ..., Application Type: New NVO & OFF. International First Service USA, Inc. dba Global Wine Logistics, Inc. (NVO..., (Qualifying Individual), Mohammad A. Madi, President, Application Type: Add NVO Service. Nano Express Corp... Type: New OFF License. Zai Cargo, Inc. dba Zai Ocean Services dba Zai Container Line (NVO & OFF),...

  3. Residency Applicants Misinterpret Their United States Medical Licensing Exam Scores

    Science.gov (United States)

    Jones, Roger C.; Desbiens, Norman A.

    2009-01-01

    Proper interpretation of the results of the United States Medical Licensing Exam (USMLE) is important for program directors, residents, and faculty who advise applicants about applying for residency positions. We suspected that applicants often misinterpreted their performance in relationship to others who took the same examination. In 2005, 54…

  4. 78 FR 48870 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-12

    ..., Application Type: QI Change. D. Martin LLC (OFF), 2915 Quail Run Drive, Humble, TX 77396, Officer: Dorsille Martin, Managing Member (QI), Application Type: New OFF License. Global Customs Services, LLC (NVO & OFF...., Grand Rapids, MI 49512, Officers: Peter G. Gonzales, Vice President (QI), James Ward, COO,...

  5. 77 FR 64991 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-24

    ...), Joosup Jung, CEO. Application Type: New NVO & OFF License. E.T.H. Cargo Services Inc. (OFF), Av. Galicia..., Miami, FL 33178. Officers: Chris Merritt, Vice President (QI), John H. Williford, President. Application... & OFF), 1400 Glenn Curtiss Street, Carson, CA 90746. Officers: Thomas Donahue, III, Vice President...

  6. 78 FR 37540 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-21

    ..., Application Type: New NVO & OFF License. Allyn International Services, Inc. (OFF), 13391 McGregor Blvd., Fort..., Vice President (QI), James A. Williams, CEO, Application Type: QI Change. Thomas Griffin International, Inc. dba Sea Lion Ocean Freight (NVO), 15903 Kent Ct., Tampa, FL 33647, Officer: Thomas L....

  7. 47 CFR 80.55 - Application for a fleet station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a fleet station license. 80.55... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.55 Application for a fleet... different vessels on the same application. Under these circumstances a fleet station license may be...

  8. 10 CFR 30.32 - Application for specific licenses.

    Science.gov (United States)

    2010-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION RULES OF GENERAL APPLICABILITY TO DOMESTIC LICENSING OF BYPRODUCT... of the source or device are adequate to protect health and minimize danger to life and property. Such..., and documentation that each individual meets the requirements of an authorized nuclear pharmacist...

  9. 78 FR 23252 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-18

    ... Global Expeditors, Limited Liability Company (NVO & OFF), 4 Englehard Avenue, Avenel, NJ 07001, Officer... Company (NVO & OFF), 621 East Olive Avenue, Suite 104, ] Burbank, CA 91501, Officer: Abet Mehrabian..., Application Type: New OFF License Total Global Solutions, Inc. (NVO & OFF), 4290 Bells Ferry Road, 244,...

  10. 77 FR 66841 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-07

    ... Manager (QI). Application Type: Add NVO Service. Motoni Global Investment Company, Incorporated dba Motoni Global Travel/Shipping (OFF), 4748 Lake Mirror Place, Forest Park, GA 30297. Officers: Olajide T. Oni... License. Encompass Global Logistics, LLC (NVO & OFF), 18881 Von Karmen Avenue, Suite 1450, Irvine,...

  11. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-27

    ... of Operations (QI), Todd Colin, CEO, Application Type: New NVO License GAL GROUP INC. (NVO & OFF...), 1720 NW. 94th Avenue, Miami, FL 33172, Officers: Jorge L. Garcia, President (QI), Nora V. Garcia, Vice... Type: QI Change Priority RoRo Services, Inc. (NVO), Pier 15, Miraflores Avenue, San Juan, PR...

  12. 76 FR 78007 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-15

    ... OTI@fmc.gov . Aieca International Logistics Corp (OFF), 5583 NW 72 Avenue, Miami, FL 33166, Officer..., (Qualifying Individual), Martin Huen, Vice President, Application Type: QI Change. Friendship Logistics LLC... License. Midas International Investments LLC dba Midas Express, Shipping and Freight (NVO), 142223...

  13. 76 FR 72409 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-23

    ...), Application Type: New OFF License. MBM International Logistics, LLC (NVO & OFF), 650 Atlanta South Parkway... OTI@fmc.gov . AE Eagle Logistics Inc. (NVO & OFF), 765 Route 83, Suite 111, Bensenville, IL 60106... Type: Add OFF Service. Asecomer International Corporation dba Interworld Freight, Inc. dba Junior...

  14. 76 FR 71034 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-16

    .... Application Type: Name Change. Abco International Freight (USA) Inc. dba Abco Logistics (NVO), 9420 Telstar...: New NVO & OFF License. Transco International Logistics LLC (OFF), 138-04 175th Street, Jamaica, NY... OTI@fmc.gov . AAB Global Logistics, LLC (NVO & OFF), 201 E. Dundee Road, 2, Palatine, IL...

  15. 76 FR 62407 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-07

    ... OTI@fmc.gov . Alltransport International Logistics, Inc. (NVO), 63 65th Place, Long Beach, CA 90803... License. American Global Logistics LLC dba AGL (NVO & OFF), 3399 Peachtree Road, NE., 1130, Atlanta, GA... Brodecki, Chairman, Application Type: QI Change. Crowley Logistics, Inc. (NVO & OFF), 9487 Regency...

  16. 77 FR 35384 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-13

    ... Individual), Application Type: New NVO & OFF License Deep Ocean International Logistics LLC (NVO), 9814... Type: QI Change Swift International Logistics, Inc. (NVO), 3 Powell Drive, West Orange, NJ 07052... OTI@fmc.gov . ABC Trucking and Logistics L.L.C. (OFF), 3080 McCall Drive, Suite 1, Atlanta, GA...

  17. 78 FR 57633 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-19

    ...-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF) pursuant to section 19 of the Shipping... NVO & OFF License. Next Generation Logistics Inc (NVO & OFF), 7325 Adams Street, Paramount, CA 90273.... Kristol, Vice President (QI), John H. Williford, President, Application Type: QI Change. Swift...

  18. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    ...), 1825-C Cross Beam Drive, Charlotte, NC 28217, Officer: David E. Sitton, Managing Member (Qualifying..., Maritime NVOCC (OFF), 2081 Raritan Road, Scotch Plains, NJ 07076, Officers: Robin Lynch, Managing Member (Qualifying Individual), Gina Lynch, Member, Application Type: License Transfer. Orion SLM LLC (NVO &...

  19. 75 FR 70673 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-18

    ... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF)--Ocean Transportation Intermediary (OTI... Line, L.C. dba Active Freight & Logistics (NVO), One Blue Hill Plaza, Pearl River, NY 10965,...

  20. 75 FR 46938 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-04

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION..., Manager, Application Type: New NVO & OFF License. Duke System Logistics Inc. (NVO & OFF), 18645 E. Gale.... Gina Marie Cianelli dba Global Bookings (OFF), 261 Jerry Allen Ridge, Dallas, GA 30132, Officer: Gina...

  1. 78 FR 48435 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-08

    ...), 13101 Moore Street, Cerritos, CA 90703, Officers: Ki Hyeon Lee, CFO (QI), Seong Won Lee, CEO... (OFF), 320 Harbor Way, South San Francisco, CA 94080, Officers: Raymond Wong, Chairman (QI), John Tree, CEO, Application Type: License Transfer to Raymond Express International, LLC. RMT Logistics Inc....

  2. 75 FR 12748 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-03-17

    ..., President/COO, (Qualifying Individual), Gregory E. Burns, Director. Supply Chain Services, LLC, 847 West... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to...

  3. Licensed reactor nuclear safety criteria applicable to DOE reactors

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    This document is a compilation and source list of nuclear safety criteria that the Nuclear Regulatory Commission (NRC) applies to licensed reactors; it can be used by DOE and DOE contractors to identify NRC criteria to be evaluated for application to the DOE reactors under their cognizance. The criteria listed are those that are applied to the areas of nuclear safety addressed in the safety analysis report of a licensed reactor. They are derived from federal regulations, USNRC regulatory guides, Standard Review Plan (SRP) branch technical positions and appendices, and industry codes and standards.

  4. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    This document is a compilation and source list of nuclear safety criteria that the Nuclear Regulatory Commission (NRC) applies to licensed reactors; it can be used by DOE and DOE contractors to identify NRC criteria to be evaluated for application to the DOE reactors under their cognizance. The criteria listed are those that are applied to the areas of nuclear safety addressed in the safety analysis report of a licensed reactor. They are derived from federal regulations, USNRC regulatory guides, Standard Review Plan (SRP) branch technical positions and appendices, and industry codes and standards

  5. 77 FR 41206 - Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control...

    Science.gov (United States)

    2012-07-12

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan...

  6. 77 FR 58419 - Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control...

    Science.gov (United States)

    2012-09-20

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan and Acceptance...

  7. 76 FR 63668 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2011-10-13

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan and Acceptance...

  8. License renewal - an idea whose time has come. Hatch nuclear plant license renewal program: an actual example of application of the license renewal rule to the Intake Structure

    International Nuclear Information System (INIS)

    After the NRC issued a revised license renewal rule in May 1995, the nuclear industry focussed on developing generic industry for implementing the rule and testing the guidance through various demonstration programs and work products in conjunction with the NRC. In addition, plant-specific programs also proceeded forward. These activities show that implementation issues continue to exist. Since the issuance of the rule, the NRC has issued a draft standard review plan for license renewal (SRP-LR), working draft, September 1997. Southern Nuclear Operating Company (SNC) has begun development work on a license renewal application for Plant Hatch Units 1 and 2. Plant Hatch Units 1 and 2 are BWR 4, Mark I plants whose operating licenses expire in 2014 and 2018, respectively. The Plant Hatch initiative also involves teaming with other boiling water reactors (BWRs) to develop the license renewal technology within the BWR fleet, and to support Plant Hatch by providing an oversight role for the application process. The teaming effort involved two other utilities, each being assigned to prepare a common report on a mechanical system or a structure. The common report could be presented to the NRC with modifications to suit the individual plants, thereby saving time and money, and hopefully resulting in quicker approval by the NRC. The desired license renewal process end result is a renewed license with up to a 20 year extension (10CFR 54.31(b)). (orig.)

  9. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Science.gov (United States)

    2010-04-01

    ... for exemption from licensing. 4.107 Section 4.107 Conservation of Power and Water Resources FEDERAL... 5 Megawatts or Less § 4.107 Contents of application for exemption from licensing. (a) General requirements. An application for exemption from licensing submitted under this subpart must contain...

  10. Semiconductor nanostructures in biological applications

    Energy Technology Data Exchange (ETDEWEB)

    Alexson, Dimitri [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Chen Hongfeng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Cho, Michael [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Dutta, Mitra [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Li Yang [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Shi, Peng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Raichura, Amit [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Ramadurai, Dinakar [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Parikh, Shaunak [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Stroscio, Michael A [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Vasudev, Milana [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States)

    2005-07-06

    Semiconductor nanostructures in biological applications are discussed. Results are presented on the use of colloidal semiconductor quantum dots both as biological tags and as structures that interact with and influence biomolecules. Results are presented on the use of semiconducting carbon nanotubes in biological applications. (topical review)

  11. Licensed reactor nuclear safety criteria applicable to DOE reactors

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    The Department of Energy (DOE) Order DOE 5480.6, Safety of Department of Energy-Owned Nuclear Reactors, establishes reactor safety requirements to assure that reactors are sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that adequately protects health and safety and is in accordance with uniform standards, guides, and codes which are consistent with those applied to comparable licensed reactors. This document identifies nuclear safety criteria applied to NRC (Nuclear Regulatory Commission) licensed reactors. The titles of the chapters and sections of USNRC Regulatory Guide 1.70, Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants, Rev. 3, are used as the format for compiling the NRC criteria applied to the various areas of nuclear safety addressed in a safety analysis report for a nuclear reactor. In each section the criteria are compiled in four groups: (1) Code of Federal Regulations, (2) US NRC Regulatory Guides, SRP Branch Technical Positions and Appendices, (3) Codes and Standards, and (4) Supplemental Information. The degree of application of these criteria to a DOE-owned reactor, consistent with their application to comparable licensed reactors, must be determined by the DOE and DOE contractor.

  12. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) Order DOE 5480.6, Safety of Department of Energy-Owned Nuclear Reactors, establishes reactor safety requirements to assure that reactors are sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that adequately protects health and safety and is in accordance with uniform standards, guides, and codes which are consistent with those applied to comparable licensed reactors. This document identifies nuclear safety criteria applied to NRC [Nuclear Regulatory Commission] licensed reactors. The titles of the chapters and sections of USNRC Regulatory Guide 1.70, Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants, Rev. 3, are used as the format for compiling the NRC criteria applied to the various areas of nuclear safety addressed in a safety analysis report for a nuclear reactor. In each section the criteria are compiled in four groups: (1) Code of Federal Regulations, (2) US NRC Regulatory Guides, SRP Branch Technical Positions and Appendices, (3) Codes and Standards, and (4) Supplemental Information. The degree of application of these criteria to a DOE-owned reactor, consistent with their application to comparable licensed reactors, must be determined by the DOE and DOE contractor

  13. 78 FR 71675 - License Amendment Application for Vermont Yankee Nuclear Power Station

    Science.gov (United States)

    2013-11-29

    ... COMMISSION License Amendment Application for Vermont Yankee Nuclear Power Station AGENCY: Nuclear Regulatory... Operating License No. DPR-28 for the Vermont Yankee Nuclear Power Station, located in Windham County, VT... proposed amendment to Facility Operating License No. DPR-28 for the Vermont Yankee Nuclear Power...

  14. 78 FR 2986 - Northern Indiana Public Service Company; Notice of Application for Temporary Variance of License...

    Science.gov (United States)

    2013-01-15

    ... Variance of License Article 403 and Soliciting Comments, Motions to Intervene and Protests Take notice that... inspection: a. Application Type: Extension of temporary variance of license article 403. b. Project No: 12514... Commission to grant an extension of time to a temporary variance of license Article 403 that was granted...

  15. 78 FR 21930 - Aquenergy Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2013-04-12

    ... Energy Regulatory Commission Aquenergy Systems, Inc.; Notice of Intent To File License Application... Filing: Notice of Intent to File License Application and Request to Use the Traditional Licensing Process. b. Project No.: P-2428-004. c. Date Filed: November 11, 2012. d. Submitted by: Aquenergy...

  16. Synthetic Biology for Therapeutic Applications

    OpenAIRE

    Abil, Zhanar; Xiong, Xiong; Zhao, Huimin

    2014-01-01

    Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug d...

  17. 76 FR 4417 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2011-01-25

    ... Maritime Administration Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License... Deepwater Port License Application. The application describes an offshore natural gas deepwater port.... Summary of the Application Liberty Natural Gas, LLC, proposes to own, construct, and operate a natural...

  18. 76 FR 72984 - Revised Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2011-11-28

    ... published in the Federal Register on Tuesday, March 30, 2010 (75 FR 15743-15744). Pursuant to 10 CFR 110.70... promulgated in August 2007, 72 FR 49139 (Aug. 28, 2007). Information about filing electronically is available... COMMISSION Revised Application for a License To Export High-Enriched Uranium The application for a license...

  19. 77 FR 21592 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2012-04-10

    ... published in the Federal Register for comment on October 13, 2011 (76 FR 63668). This draft ISG provides... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format...

  20. Total System Performance Assessment-License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2002-09-13

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issue (KTI) agreements, the ''Yucca Mountain Review Plan'' (CNWRA 2002 [158449]), and 10 CFR Part 63. This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are utilized in this document.

  1. Total System Performance Assessment - License Application Methods and Approach

    International Nuclear Information System (INIS)

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document

  2. License Application Design Selection Report, REV 01. August 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, C.R.

    1999-08-30

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value

  3. 77 FR 16278 - License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear...

    Science.gov (United States)

    2012-03-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear Operations, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent...

  4. 77 FR 23719 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-20

    ... Type: New NVO License. Bertschi North America Inc. (NVO), 15811 Heatherdale Drive, Houston, TX 77059. Officers: Eloy Ramos, Director/President/Secretary/ Treasurer (Qualifying Individual), Hans J....

  5. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  6. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    International Nuclear Information System (INIS)

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  7. 77 FR 50534 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-08-21

    ... associated with confidence in the ability of the fission product barriers (i.e., fuel cladding, Reactor... nuclear material as reactor fuel, in accordance with the limitations for storage and amounts required for..., Director, Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE...

  8. 76 FR 78702 - Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant...

    Science.gov (United States)

    2011-12-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant, Units 1 and 2) Notice of Atomic Safety and Licensing Board Reconstitution Pursuant to 10 CFR...

  9. 78 FR 37324 - Preparation of Environmental Reports for Nuclear Power Plant License Renewal Applications

    Science.gov (United States)

    2013-06-20

    ... COMMISSION 10 CFR Parts 51 and 54 RIN 3150-AI42 Preparation of Environmental Reports for Nuclear Power Plant..., Supplement 1 (RG 4.2S1), ``Preparation of Environmental Reports for Nuclear Power Plant License Renewal.... Applicants should use this regulatory guide when preparing an environmental report for license renewal...

  10. 76 FR 5582 - Whitestone Power and Communications; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2011-02-01

    ... Necessary for Expedited Processing of a Hydrokinetic Pilot Project License Application, and Soliciting... Original License for a Hydrokinetic Pilot Project. b. Project No.: 13305-001. c. Date Filed: January 18... RISEC Project.\\1\\ \\1\\ The project was named the Microturbine Hydrokinetic River- In-Stream...

  11. 77 FR 71822 - Notice of Invitation-Coal Exploration License Application MTM 103852, MT

    Science.gov (United States)

    2012-12-04

    ... Drive, Billings, Montana. A written notice to participate in the exploration licenses should be sent to the State Director, BLM Montana State Office, 5001 Southgate Drive, Billings, MT 59101 and Ambre... Bureau of Land Management Notice of Invitation--Coal Exploration License Application MTM 103852,...

  12. 77 FR 61584 - FFP Missouri 12, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Missouri 12, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process a. Type of...

  13. The annotated outlined process for a mined geologic disposal system license application

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is studying Yucca Mountain, Nevada, as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to license the potential repository; if the site is found suitable, a license application would be submitted to the U.S. Nuclear Regulatory Commission (NRC). Current plans are to submit the license application in 2001. To manage development of the license application, DOE has developed the Mined Geologic Disposal System Annotated Outline for License Application (AO). The AO provides a method to verify the site characterization program and to implement the guidance given by the NRC in their draft regulatory guide on the license application. In addition, the AO facilities focused interactions with the NRC and will contribute to the clarification of the regulations. The development of the AO is an interactive process; revisions are produced semiannually, and transmitted to the NRC to provide information and to facilitate NRC's staff guidance to DOE. The AO is an effective method to manage the complex and challenging regulatory and technical information requirements for development of the license application

  14. Automated License Plate Recognition for Toll Booth Application

    Directory of Open Access Journals (Sweden)

    Ketan S. Shevale

    2014-10-01

    Full Text Available This paper describes the Smart Vehicle Screening System, which can be installed into a tollbooth for automated recognition of vehicle license plate information using a photograph of a vehicle. An automated system could then be implemented to control the payment of fees, parking areas, highways, bridges or tunnels, etc. There are considered an approach to identify vehicle through recognizing of it license plate using image fusion, neural networks and threshold techniques as well as some experimental results to recognize the license plate successfully.

  15. Total System Performance Assessment - License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2003-12-08

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document.

  16. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    International Nuclear Information System (INIS)

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  17. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  18. 76 FR 1612 - Natural Currents Energy Services, LLC; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2011-01-11

    ... Regulations Necessary for Expedited Processing of a Hydrokinetic Pilot Project License Application, and... Original License for a Hydrokinetic Pilot Project. b. Project No.: 13247-001. c. Date Filed: December 22... intent (NOI) to file an application for an original license for a hydrokinetic pilot project and a...

  19. 75 FR 11151 - Pacific Gas and Electric Company; Notice of Intent To File License Application, Filing of Draft...

    Science.gov (United States)

    2010-03-10

    ... Necessary for Expedited Processing of a Hydrokinetic Pilot Project License Application, and Soliciting... License for a Hydrokinetic Pilot Project. b. Project No.: 12779-005. c. Date Filed: March 1, 2010. d... hydrokinetic pilot project and a draft license application with monitoring plans; (2) a request for waivers...

  20. 78 FR 73566 - Standard Format and Content for a License Application for an Independent Spent Fuel Storage...

    Science.gov (United States)

    2013-12-06

    ... COMMISSION Standard Format and Content for a License Application for an Independent Spent Fuel Storage... public comment draft regulatory guide (DG), DG-3042, ``Standard Format and Content for a License... Waste'' (Ref. 1), Subpart B, ``License Application, Form, and Contents,'' specifies the information...

  1. 78 FR 38336 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-26

    ... Express, LLC (NVO & OFF), 812 Downtowner Blvd., Suite K, Mobile, AL 36609, Officers: Thomas (Mac) H. Mc... License. Magnum-Ramstr Cargo LLC (NVO & OFF), 2 Ethel Road, Suite 202C, Edison, NJ 08817,...

  2. 7 CFR 1530.104 - Application for a license.

    Science.gov (United States)

    2010-01-01

    ... any wholly-owned subsidiary(s) and plant(s) in the case of a consolidated license, and including those... affiliated with any other licensee, or explaining any affiliations, should they exist. (b) A...

  3. 78 FR 36014 - Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-14

    ... License Applications in the Federal Register (78 FR 25349-25351) advising the public that nautical miles.... Roddy Bachman, U.S. Coast Guard, telephone: 202-372-1451, email: Roddy.C.Bachman@uscg.mil or Ms....

  4. Environmental Standard Review Plan for the review of license renewal applications for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, J.; Kim, T.J.; Reynolds, S.

    1991-08-01

    The Environmental Standard Review Plan for the Review of License Applications for Nuclear Power Plants (ESRP-LR) is to be used by the NRC staff when performing environmental reviews of applications for the renewal of power reactor licenses. The use of the ESRP-LR provides a framework for the staff to determine whether or not environmental issues important to license renewal have been identified and the impacts evaluated and provides acceptance standards to help the reviewers comply with the National Environmental Policy Act.

  5. Overview of the earth mounded concrete bunker prototype license application project: Objectives and approach

    Energy Technology Data Exchange (ETDEWEB)

    Conner, J.E. [EG and G Idaho, Inc., Idaho Falls, ID (United States). Idaho National Engineering Lab.

    1989-11-01

    This paper presents an overview of the objectives and approach taken in developing the Earth-mounded Concrete Bunker Prototype License Application Project. The Prototype License Application Project was initiated by the Department of Energy`s National Low-Level Waste Management Program in early 1987 and completed in November 1988. As part of this project a prototype safety analysis report was developed. The safety analysis report evaluates the licensibility of an earth-mounded concrete bunker for a low-level radioactive waste (LLW) disposal facility located on a hypothetical site in the northeastern United States. The project required approximately five person-years and twenty months to develop.

  6. Environmental Standard Review Plan for the review of license renewal applications for nuclear power plants

    International Nuclear Information System (INIS)

    The Environmental Standard Review Plan for the Review of License Applications for Nuclear Power Plants (ESRP-LR) is to be used by the NRC staff when performing environmental reviews of applications for the renewal of power reactor licenses. The use of the ESRP-LR provides a framework for the staff to determine whether or not environmental issues important to license renewal have been identified and the impacts evaluated and provides acceptance standards to help the reviewers comply with the National Environmental Policy Act

  7. 76 FR 19097 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-06

    ... Type: License Transfer. Green Line Shipping & Logistics Services Inc. (NVO), 16230 Lake View Lane... OTI@fmc.gov . Agility Logistics Corp. (OFF), 240 Commerce, Irvine, CA 92602, Officers: Michael G... 57th Avenue, Oakland, CA 94621, Officers: Gary Sachs, Partner/Logistics Manager (Qualifying...

  8. 76 FR 79682 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-22

    .... Premier Logistics Management LLC (NVO & OFF), 3727 59th Avenue Circle E., Ellenton, FL 34222. Officer... OTI@fmc.gov . A.C.T. Logistics, LLC (NVO), 154-09 146th Avenue, 3rd Floor, Jamaica, NY 11434. Officers... Type: License Transfer. Canyon Global Logistics, LLC (NVO & OFF), 2928-B Greens Road, Suite...

  9. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-06

    ... License. Transtek Logistics, LLC dba Freight Logistics International (NVO), 3505 NW 107th Avenue, Suite C.... vmlog international logistics U.S.A. ``L.L.C.'' (NVO & OFF), 7025 Hodgson Memorial Drive, Suite B... telephone at (202) 523-5843 or by email at OTI@fmc.gov . Action One Logistics, Inc. (NVO & OFF), 115...

  10. 21 CFR 515.10 - Medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... Veterinary Medicine home page at http://www.fda.gov/cvm. (b) A completed medicated feed mill license must..., manufacturing, processing, packaging, and holding such animal feeds conform to current good manufacturing... (HFV-220), Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Pl.,...

  11. 77 FR 49445 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-08-16

    .... (NVO), One Slater Drive, Elizabeth, NJ 07206, Officers: Thomas O'Rourke, Assistant Secretary... Services International Corp. (NVO), 10257 NW 52nd Terrace, Doral, FL 33178, Officers: Carla L. Imach... License. I.T.N. Consolidators, Inc. (NVO), 3401-C NW. 72nd Avenue, Miami, FL 33122, Officers: Juan...

  12. Removal of Review and Reclassification Procedures for Biological Products Licensed Prior to July 1, 1972. Final rule.

    Science.gov (United States)

    2016-02-12

    The Food and Drug Administration (FDA, the Agency, or we) is removing two regulations that prescribe procedures for FDA's review and classification of biological products licensed before July 1, 1972. FDA is taking this action because the two regulations are obsolete and no longer necessary in light of other statutory and regulatory authorities established since 1972, which allow FDA to evaluate and monitor the safety and effectiveness of all biological products. In addition, other statutory and regulatory authorities authorize FDA to revoke a license for biological products because they are not safe and effective, or are misbranded. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation. PMID:26878738

  13. 78 FR 75386 - Entergy Operations, Inc.; Combined License Application for River Bend Station Unit 3, Exemption...

    Science.gov (United States)

    2013-12-11

    ... Register on November 3, 2011 (76 FR 72560). Part 50, Appendix E, Section I.5 gives those COL applicants... Preparedness (EP) rules in their Combined License (COL) application. The NRC staff reviewed this request and... submitted prior to, or coincident with, requesting the NRC to resume its review of the COL application,...

  14. 75 FR 57820 - Luminant Generation Company, LLC.; Combined License Application for Comanche Peak Nuclear Power...

    Science.gov (United States)

    2010-09-22

    ..., Combined License (COL) Application, Docket Numbers 52-034 and 52-035, submitted by Luminant Generation... of a COL application until the NRC makes a finding under 10 CFR 52.103(g) pertaining to facility... Analysis Report (FSAR). The proposed exemption would allow Luminant to submit its COL application...

  15. Structural Biology: Practical NMR Applications

    CERN Document Server

    Teng, Quincy

    2005-01-01

    This textbook begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

  16. The contractor`s role in low-level waste disposal facility application review and licensing

    Energy Technology Data Exchange (ETDEWEB)

    Serie, P.J.; Dressen, A.L. [Environmental Issues Management, Inc., Seattle, WA (United States)

    1991-12-31

    The California Department of Health Services will soon reach a licensing decision on the proposed Ward Valley low-level radioactive waste disposal facility. As the first regulatory agency in the country to address the 10 CFR Part 61 requirements for a new disposal facility, California`s program has broken new ground in its approach. Throughout the review process, the Department has relied on contractor support to augment its technical and administrative staff. A team consisting of Roy F. Weston, Inc., supported by ERM-Program Management Corp., Environmental Issues Management, Inc., and Rogers and Associates Engineering Corporation, has worked closely with the Department in a staff extension role. The authors have been involved with the project in contractor project management roles since 1987, and continue to support the Department`s program as it proceeds to finalize its licensing process. This paper describes the selection process used to identify a contractor team with the needed skills and experience, and the makeup of team capabilities. It outlines the management, communication, and technical approaches used to assure a smooth agency-contractor function and relationship. It describes the techniques used to ensure that decisions and documents represented the Department credibly in its role as the regulatory and licensing agency under the Nuclear Regulatory Commission (NRC) Agreement State program. The paper outlines the license application review process and activities, through preparation of licensing documentation and responses to public comments. Lessons learned in coordination of an agency-contractor team effort to review and license a low-level waste disposal facility are reviewed and suggestions made for approaching a similar license application review and licensing situation.

  17. Preparing to Submit a License Application for Yucca Mountain

    International Nuclear Information System (INIS)

    In 1982, the U.S. Congress passed the Nuclear Waste Policy Act, a Federal law that established U.S. policy for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Congress amended the Act in 1987, directing the Department of Energy to study only Yucca Mountain, Nevada as the site for a permanent geologic repository. As the law mandated, the Department evaluated Yucca Mountain to determine its suitability as the site for a permanent geologic repository. Decades of scientific studies demonstrated that Yucca Mountain would protect workers, the public, and the environment during the time that a repository would be operating and for tens of thousands of years after closure of the repository. A repository at this remote site would also: preserve the quality of the environment; allow the environmental cleanup of Cold War weapons facilities; provide the nation with additional protection from acts of terrorism; and support a sound energy policy. Throughout the scientific evaluation of Yucca Mountain, there has been no evidence to disqualify Yucca Mountain as a suitable site for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Upon completion of site characterization, the Secretary of Energy considered the results and concluded that a repository at Yucca Mountain would perform in a manner that protects public health and safety. The Secretary recommended the site to the President in February 2002; the President agreed and recommended to Congress that the site be approved. The Governor of Nevada submitted a notice of disapproval, and both houses of Congress acted to override the disapproval. In July 2002, the President's approval allowed the Department to begin the process of submittal of a license application for Yucca Mountain as the site for the nation's first repository for spent nuclear fuel and high-level radioactive waste. Yucca Mountain is located on federal land in Nye County in southern Nevada, an arid region

  18. 77 FR 20622 - N.E.W. Hydro LLC; Notice of Application for Amendment of License and Soliciting Comments, Motions...

    Science.gov (United States)

    2012-04-05

    ... Energy Regulatory Commission N.E.W. Hydro LLC; Notice of Application for Amendment of License and...: Amendment of License. b. Project No.: 2744-041 & 042. c. Date Filed: March 14, 2012. d. Applicant: N.E.W... agency. k. Description of Application: N.E.W. Hydro LLC seeks approval to construct an angled...

  19. 33 CFR 211.9 - Applications for leases, easements, licenses, and permits.

    Science.gov (United States)

    2010-07-01

    ... WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.9 Applications for leases, easements, licenses, and permits. Applications for use of Civil Works property should be made to the District Engineer of the district within the boundaries of which the real estate is located....

  20. 78 FR 79506 - Tennessee Valley Authority: Exemption From Requirements To Revise Combined License Application To...

    Science.gov (United States)

    2013-12-30

    ... revise their COL application to comply with the EP rules published in the Federal Register (76 FR 72560... revise their combined license (COL) application in order to address enhancements to the Emergency Preparedness (EP) rules at the same time as requesting the NRC to resume the review of their COL...

  1. 76 FR 800 - Ameren Missouri, Combined License Application for Callaway Plant Unit 2; Environmental Assessment...

    Science.gov (United States)

    2011-01-06

    ...) for the Callaway Plant (Callaway), Unit 2, Combined License (COL) Application, Docket Number 52-037... located in Callaway ] County, Missouri. The NRC's review activities relating to the Callaway, Unit 2, COL... adjudicatory proceedings related to the Callaway, Unit 2, COL application were terminated by the Atomic...

  2. 76 FR 34970 - Avista Corporation; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-06-15

    ... project hydraulic capacity from 23,550 cfs to 24,650 cfs. l. A copy of the application is available for...: Amendment of License. b. Project No.: 2545-148. c. Date Filed: April 15, 2011. d. Applicant: Avista Corporation. e. Name of Project: Spokane River Project. f. Location: The project is located on the...

  3. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z., E-mail: jonatasfmata@yahoo.com.br, E-mail: vasconv@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  4. E-Licensing in DGFT: A Best E-Governance Application

    Directory of Open Access Journals (Sweden)

    V. S. Rana

    2013-07-01

    Full Text Available This is a case of effective and efficient e-Governance where the licenses are issued electronically by using of IT for web based delivery service in the Directorate General of Foreign Trade (DGFT. Now a days complete licensing procedure is dealing through electronically i.e. Exporter/Importer apply electronically to get the Importer Exporter Code( IEC , submitting the fees as well as necessary documents electronically and received the IEC electronically. Trading Community is also availing the Online facility to submit the application for any licensing scheme, depositing the licensing fees, enclosing the required document from their end. The official procedure is also automated like initiating the note sheet, generating the ecom number, consolation of license fees and issuing the license to the exporter. There is fifty percent role of customs involved in trading. So that Electronic Data Interchange(EDI facility is also established with Customs. In addition to above services, Bank Realization Certificate(BRC is also integrated with this system. Henceforth an Exporter/Importer is equipped with electronic services without visiting to the office of DGFT, Customs and Bank. The web has been strategically leveraged for reengineering and transformation of trade processes for an economic trade facilitation.

  5. Information to be submitted in support of licensing applications for nuclear power plants

    International Nuclear Information System (INIS)

    This Safety Guide was prepared as part of the Agency's programme, referred to as the NUSS programme, for establishing Codes of Practice and Safety Guides relating to nuclear power plants. It supplements the Agency's Safety Series No.50-C-G, entitled ''Governmental Organization for the Regulation of Nuclear Power Plants: A Code of Practice''. It is concerned with the content of documents which should be submitted to the regulatory body by the applicant/licensee in support of licensing applications, with a possible method of classifying these documents and with the scheduling of their submission to the regulatory body at each major stage of the licensing process

  6. 77 FR 1924 - FFP Missouri 15, LLC; FFP Missouri 16, LLC; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2012-01-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Missouri 15, LLC; FFP Missouri 16, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process...

  7. 77 FR 63812 - FFP Missouri 5, LLC; FFP Missouri 6, LLC; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2012-10-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Missouri 5, LLC; FFP Missouri 6, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process...

  8. 76 FR 16420 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-03-23

    ... Logistics Officer (Qualifying Individual), Jack R. Lentz, CEO/Chairman/ Secretary, Application Type: New NVO... (Qualifying Individual), Kazuo Ishizuka, President/CEO, Application Type: Business Structure Change and...

  9. Partnering with Industry to Deliver Continuing Education to Florida's Licensed Pesticide Applicators

    Science.gov (United States)

    Fishel, Fred

    2014-01-01

    Partnering with private industry can empower Extension educators to enhance their educational outreach efforts. Since 2011, UF/IFAS has cooperated with the Florida Turfgrass Association in conducting a 1-day statewide Polycom® event for providing continuing education to licensed pesticide applicators employed primarily in the ornamental and…

  10. 77 FR 14445 - Application for a License To Export Steel Forging

    Science.gov (United States)

    2012-03-09

    ... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC's public... COMMISSION Application for a License To Export Steel Forging Pursuant to 10 CFR 110.70(b) ``Public Notice of... Spain. December 15, 2011 head steel head steel February 7, 2012 forging. forging will be XR175...

  11. 78 FR 25486 - Luminant Generation Company, LLC., Combined License Application for Comanche Peak Nuclear Power...

    Science.gov (United States)

    2013-05-01

    ... COMMISSION Luminant Generation Company, LLC., Combined License Application for Comanche Peak Nuclear Power... Generation Company, LLC. (Luminant) for the proposed facility to be located in Somervell County, Texas. In... or who encounter problems in accessing the documents located in ADAMS should contact the NRC...

  12. 77 FR 73632 - American Municipal Power, Inc; Notice of Application for Temporary Variance of License and...

    Science.gov (United States)

    2012-12-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission American Municipal Power, Inc; Notice of Application for Temporary Variance of License and Soliciting Comments, Motions To Intervene, and Protests Take notice that the...

  13. 76 FR 52994 - Application for a License To Export Heavy Water

    Science.gov (United States)

    2011-08-24

    ... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC's public... COMMISSION Application for a License To Export Heavy Water Pursuant to 10 CFR 110.70 (b) ``Public Notice of... end-use for China. (D2O--heavy (liters). producing an active water). pharmaceutical ingredient...

  14. 75 FR 7525 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fuel France; Belgium. Security Complex, February 2, Uranium (93.35%). uranium (87.3 elements in...

  15. 75 FR 6223 - Application For a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-08

    ... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on timely electronic... COMMISSION Application For a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fabricate Canada. Complex December 21, 2009, Uranium (93.35%). uranium (16.3 targets for December 28,...

  16. 77 FR 73055 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... kilograms To fabricate targets The Netherlands. Security Complex. Uranium uranium-235 at CERCA AREVA October... XSNM3730 uranium. targets at the HFR 11006054 Research Reactor in the Netherlands, the BR-2 Reactor...

  17. 77 FR 51579 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-08-24

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... kilograms For the export of Canada. Complex, July 30, 2012, August Uranium (93.35%). uranium-235 high-enriched 1, 2012, XSNM3726, 11006037. contained in 7.5 uranium in the kilograms uranium. form of...

  18. 75 FR 15743 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-03-30

    ... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC's public... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149.36 elements in March 9,...

  19. 77 FR 73056 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... August 2007, 72 FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... targets Belgium. Security Complex. Uranium (93.2%). uranium-235 at CERCA AREVA Romans October 10,...

  20. 78 FR 33448 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2013-06-04

    ... August 2007, 72 FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... targets Canada. Security Complex, May 13, Uranium (93.35%). uranium-235 at the National 2013, May 21,...

  1. 77 FR 1956 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-01-12

    ... August 2007, 72 FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(b) ``Public... Netherlands. Security Complex. Uranium uranium (9.3 targets at December 21, 2011 (93.35%). kilograms U-...

  2. 76 FR 59173 - Standard Format and Content of License Applications for Conventional Uranium Mills

    Science.gov (United States)

    2011-09-23

    ... COMMISSION Standard Format and Content of License Applications for Conventional Uranium Mills AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; withdrawal. SUMMARY: On May 30, 2008 (73 FR 31152... Conventional Uranium Mills.'' DG- 3024 was a proposed Revision 2 of Regulatory Guide (RG) 3.5. However,...

  3. Standard format and content of license applications for plutonium processing and fuel fabrication plants

    International Nuclear Information System (INIS)

    The standard format suggested for use in applications for licenses to possess and use special nuclear materials in Pu processing and fuel fabrication plants is presented. It covers general description of the plant, summary safety assessment, site characteristics, principal design criteria, plant design, process systems, waste confinement and management, radiation protection, accident safety analysis, conduct of operations, operating controls and limits, and quality assurance

  4. NEP Nuclear Power Plant, Units 1 and 2. License application, general and financial information

    International Nuclear Information System (INIS)

    A license application is presented for 2 pressurized water reactors at a proposed location in Charlestown RI. Each reactor will have a net capacity of 1150 MW. Cooling water will be supplied by the Atlantic Ocean. NEP-1 is scheduled for operation in 1983 and NEP-2 in 1985

  5. 76 FR 54753 - Whitestone Power and Communications; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2011-09-02

    ... Necessary for Expedited Processing of a Hydrokinetic Pilot Project License Application, and Soliciting... Hydrokinetic Pilot Project. b. Project No.: 13305-002. c. Date Filed: August 22, 2011. d. Submitted By: Whitestone Power and Communications. e. Name of Project: Microturbine Hydrokinetic River-In-Stream...

  6. 76 FR 39922 - Notice of Acceptance of Application for Special Nuclear Materials License From Sensor Concepts...

    Science.gov (United States)

    2011-07-07

    ... participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August...\\ Requesters should note that the filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28, 2007... COMMISSION Notice of Acceptance of Application for Special Nuclear Materials License From Sensor Concepts...

  7. 78 FR 45578 - Application For a License to Export Radioactive Waste

    Science.gov (United States)

    2013-07-29

    ... COMMISSION Application For a License to Export Radioactive Waste Pursuant to 10 CFR 110.70 (b) ``Public... electronically through ADAMS and can be accessed through the Public Electronic Reading Room (PERR) link http... electronic filing, at least 5 (five) days prior to the filing deadline, the petitioner/requestor...

  8. 77 FR 73054 - Application for a License To Export Radioactive Waste

    Science.gov (United States)

    2012-12-07

    ... COMMISSION Application for a License To Export Radioactive Waste Pursuant to 10 CFR 110.70(b) ``Public Notice... through ADAMS and can be accessed through the Public Electronic Reading Room (PERR) link http://www.nrc... public Web site at http://www.nrc.gov/site-help/e-submittals.html . To ensure timely electronic...

  9. 75 FR 70350 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2010-11-17

    ... Maritime Administration Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License.... Coast Guard received an application from Liberty Natural Gas LLC for all Federal authorizations required... the transportation, storage, and further handling of oil or natural gas for transportation to...

  10. 77 FR 39521 - Application for a License To Export Nuclear Reactor Major Components and Equipment

    Science.gov (United States)

    2012-07-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Application for a License To Export Nuclear Reactor Major Components and Equipment Pursuant to 10... Reactor internals, Components and For use in Braka nuclear power Company LLC reactor coolant equipment...

  11. 77 FR 62500 - John B. Crockett; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-10-15

    ... Federal Energy Regulatory Commission John B. Crockett; Notice of Intent To File License Application.... b. Project No.: 14355-001. c. Dated Filed: September 4, 2012. d. Submitted By: John B. Crockett. e... Pursuant to: 18 CFR 5.3 of the Commission's regulations. h. Potential Applicant Contact: John B....

  12. Thermophilic molds: Biology and applications.

    Science.gov (United States)

    Singh, Bijender; Poças-Fonseca, Marcio J; Johri, B N; Satyanarayana, Tulasi

    2016-11-01

    Thermophilic molds thrive in a variety of natural habitats including soils, composts, wood chip piles, nesting materials of birds and other animals, municipal refuse and others, and ubiquitous in their distribution. These molds grow in simple media containing carbon and nitrogen sources and mineral salts. Polyamines are synthesized in these molds and the composition of lipids varies considerably, predominantly containing palmitic, oleic and linoleic acids with low levels of lauric, palmiotoleic and stearic acids. Thermophilic molds are capable of efficiently degrading organic materials by secreting thermostable enzymes, which are useful in the bioremediation of industrial wastes and effluents that are rich in oil, heavy metals, anti-nutritional factors such as phytic acid and polysaccharides. Thermophilic molds synthesize several antimicrobial substances and biotechnologically useful miscellaneous enzymes. The analysis of genomes of thermophilic molds reveals high G:C contents, shorter introns and intergenic regions with lesser repetitive sequences, and further confirms their ability to degrade agro-residues efficiently. Genetic engineering has aided in ameliorating the characteristics of the enzymes of thermophilic molds. This review is aimed at focusing on the biology of thermophilic molds with emphasis on recent developments in the analysis of genomes, genetic engineering and potential applications. PMID:26777293

  13. 75 FR 60124 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-29

    ... A. Bekdash, Director of International Logistics (Qualifying Individual), Wasem Demashkiah, Director...), Application Type: QI Change BYTR International, Inc. (NVO & OFF), 13152 Rivergate Trail West, Jacksonville, FL.../Secretary/ Treasurer (Qualifying Individual), Application Type: Add NVO Service Montgomery International...

  14. 76 FR 41258 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-13

    ...), Alberto P. Martinez, Manager. Application Type: QI Change. Puerto Cortes Express, Inc. (NVO), 9930 NW 21st Street, 201, Miami, FL 33172. Officer: Jacqueline Reyes, President (Qualifying Individual)....

  15. 77 FR 28880 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-05-16

    ..., Inglewood, CA 90301, Officers: Edison Chen, Manager (Qualifying Individual), Wei-Nung (Janus) Lin, Member... A. Case, Vice President (Qualifying Individual), Thomas C. Case, President, Application Type:...

  16. 76 FR 67188 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-10-31

    ..., Doral, FL ] 33126, Officers: Ramiro M. Ramirez, Jr., Vice President/Director, (Qualifying Individual), Mirna Ramirez, President/Secretary/Treasurer/ Director, Application Type: Add OFF Service....

  17. 77 FR 18815 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-28

    .... Officers: Thomas L. Armel, Vice President (Qualifying Individual). Olivia De Caro, President. Application.... Oceanpar Logistix LLC (NVO & OFF), 2 Van Buren Drive, Edison, NJ 08817. Officer: Jitendra P. Shah, Member... President of Logistics (Qualifying Individual). Thomas F. Bailey, President. Application Type: New...

  18. 78 FR 35634 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-13

    ...: Stan Sing Lau, Vice President (QI), David Koch, CEO. Application Type: QI Change. Logistics Management..., President. Application Type: QI Change. Daisy Mae Concepcion V. Taleon dba DMT Global Logistics (NVO & OFF... Value International dba JP Global Logistics (NVO & OFF), 377 Oyster Point Blvd., Suite 18, South...

  19. 77 FR 72863 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-12-06

    ... Francoulon, President. Application Type: Add NVO Service. Kingz International Logistics Inc (OFF), 415 S... telephone at (202) 523-5843 or by email at OTI@fmc.gov . Air 7 Seas Transport Logistics, Inc. (NVO & OFF... & CFO. Application Type: QI Change. All International Solutions Inc. (NVO), 281 E. Redondo Beach...

  20. 76 FR 67730 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-02

    ... Services, dba AGI Logistics USA, dba AGI Logistics, 230-59 International Airport Center Blvd., 270, Jamaica.../ Director, Application Type: Add OFF Service Encore International Corp. (NVO & OFF), 12280 SW 130th Street..., Vice President, Application Type: Add NVO Service Eztrans Logistics Ltd. (NVO), 5889 Coopers...

  1. 75 FR 8720 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-02-25

    ...-Operating Common Carrier--Ocean Transportation Intermediary Applicants: Eastern Logistics LLC, 6 Elna Ct...-Vessel-Operating Common Carrier--Ocean Transportation Intermediary Applicants (Cont'd): HP International LLC dba A&M International, 367 Brooks Street, Elgin, IL 60120. Officers: Marilou Pedress,...

  2. 75 FR 66099 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-10-27

    ... & Import Service (Qualifying Individual), Joseph L. Carnes, Chairman and CEO, Application Type: Name Change... American Shipping, LLC (NVO), 10564 Progress Way, Suite E, Cypress, CA 90630, Officers: Paul D. Snell, CEO... Para, CEO, Application Type: QI Change. De Well Logistics LLC dba De Well Logistics, dba De Well...

  3. 75 FR 37805 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2010-06-30

    .... Lorrie Vidal, CEO (Qualifying Individual). Application Type: New OFF & NVO. Alisped U.S.A. Inc. (NVO... President (Qualifying Individual), Harrison Cutler, Chairman. Application Type: QI Change. Demanko HLC... LLC (NVO), 25 E. Spring Valley Avenue--Suite 100, Maywood, NJ 07607. Joseph Monaghan,...

  4. 75 FR 39667 - Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent Application

    Science.gov (United States)

    2010-07-12

    ... Department of the Army Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent... availability for licensing of the invention set forth in U.S. Patent Application Serial No. 12/149,076, entitled ``Combinations of Gene Deletions for Live Attenuated Shigella Vaccine Strains,'' filed April...

  5. 78 FR 30914 - Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-05-23

    ... Variance of License and Soliciting Comments, Motions To Intervene and Protests Take notice that the... inspection: a. Application Type: Temporary variance of license. b. Project No.: 1494-416. c. Date Filed... of Request: Grand River Dam Authority (GRDA) requests a temporary variance, for the year 2013,...

  6. 78 FR 10173 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-02-13

    ... Okolo and David Newton dba Emunah Global (NVO & OFF), 1904 Farnam Street, Suite 610, Omaha, NE 68102, Officers: David D. Newton, Partner (QI), Jerome Okolo, Partner, Application Type: New NVO & OFF...

  7. 75 FR 51074 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-18

    ..., President, (Qualifying Individual), Application Type: Add Trade Name. CLA Investment & Development, Inc. dba CLA Shipping, Inc., (NVO & OFF), 129 S. 8th Avenue, C, La Puente, CA 91746. Officers: Hong...

  8. 78 FR 75345 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-11

    .... Application Type: QI Change. Cromarti Logistics LLC (NVO), 2810 Grants Lake Blvd., Suite 904, Sugar Land, TX... Change. GPL Logistics, Inc (NVO), 18725 E. Gale Avenue, Suite 250, City of Industry, CA 91748....

  9. 76 FR 38651 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-07-01

    ... Shipping (NVO), 1861 Western Way, Torrance, CA 90501. Officers: Hseanrus (Stephen) H. Lin, President/Vice..., Application Type: QI Change. Total Caribbean Logistics, LLC (NVO & OFF), 81 Kings Court, 14B, San Juan,...

  10. 76 FR 44330 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-25

    ..., Seattle, WA 98188, Officers: Charles K. Behrens, President, (Qualifying Individual), Todd L. Halverson..., (Qualifying Individual), David P. Kratt, President, Application Type: QI Change. Direct Freight Services LLC..., Jamaica, NY 11434, Officers: Harjinder P. Singh, President/Chief Executive Manager, (Qualifying...

  11. 77 FR 10491 - City of Aspen; Notice of Intent To File License Application, Filing of Pre-Application Document...

    Science.gov (United States)

    2012-02-22

    ... Energy Regulatory Commission City of Aspen; Notice of Intent To File License Application, Filing of Pre....: 13254-002. c. Date Filed: December 12, 2011. d. Submitted By: City of Aspen. e. Name of Project: Castle Creek Hydroelectric Project. f. Location: On Maroon and Castle Creeks near the City of Aspen, in...

  12. 77 FR 59389 - Hawks Nest Hydro, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-09-27

    ... Energy Regulatory Commission Hawks Nest Hydro, LLC; Notice of Intent To File License Application, Filing...: Hawks Nest Hydro, LLC. e. Name of Project: Hawks Nest Hydroelectric Project (P-2512-069) and Glen Ferris Hydroelectric Project (P-14439-000) f. Location: Hawks Nest Hydroelectric Project is on the New River in...

  13. The regulatory review of construction license application and the supporting safety case

    International Nuclear Information System (INIS)

    Finland is one of the foremost countries in the world in developing the disposal of spent fuel. The construction license application for the Olkiluoto spent fuel disposal facility was submitted to the authorities at the end of 2012 and the facility is expected to start operation around 2020. This has been a long-term project with over 30 years of parallel development of the repository project and the regulatory approach to spent fuel management. In 1983 the government made a strategic decision on the objectives and target time schedule for the research, development and technical planning of nuclear waste management. While an export and international disposal solution was still the preferred option, this decision required the licensees without this possibility to prepare for disposal in Finland and it also gave the time line for the milestones on the way to an operating disposal facility by 2020. The licensing procedure for a disposal facility has several steps that are similar to all nuclear facilities in Finland and are defined in Nuclear Energy Act and Decree (1987, 1988). These licensing steps are: - Decision-in-principle is required for a nuclear facility having considerable general significance. This is essentially a political decision: the government decides if the construction project is in line with the overall good of society. The decision can be applied for one or more sites, the host municipality has a veto right and the parliament has the choice of ratifying or not ratifying the decision. - Construction license is granted by the government and authorises the construction of the disposal facility. The actual construction is regulated by STUK and includes several review and approval steps, hold points and viewpoints. - Operational license is granted by the government and authorises the operation of the facility for a certain period. The operational license is needed before nuclear waste can be disposed. The first step in the licensing process was reached

  14. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    Energy Technology Data Exchange (ETDEWEB)

    Silverman, D.J.; Bauser, M.A. [Morgan, Lewis and Bockius, Washington, DC (United States); Baird, R.D. [Rogers and Associates Engineering Corp., Salt Lake City, UT (United States)

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application.

  15. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    International Nuclear Information System (INIS)

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  16. 78 FR 43202 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-07-19

    ...), 8000 NW 29th Street, Miami, FL 33122, Officers: Adrian Martinez, Operations Manager (QI), Jose G. Suarez, Sales Manager, Application Type: QI Change. UBA Express Cargo, Corp. (NVO), 10350 West Flagler..., Suite 6, Miami, FL 33178, Officers: Paul Selvage, Member (QI), Steven Periman,...

  17. Barnwell Nuclear Fuel Plant. License application, amendment 10

    International Nuclear Information System (INIS)

    Amendment No. 10 provides the applicant's responses to questions raised by the AEC in letters dated November 6 and December 5, 1974. Amendment No. 3, dated February 1975, to the BNFP Separations Facility Final Safety Analysis Report (FSAR) is included. The amendment consists of revision pages for volumes 1 through 5 of the FSAR along with a deletion and insertion guide. (U.S.)

  18. 76 FR 59128 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-09-23

    ... at OTI@fmc.gov . APLUS Worldwide Logistics, Corp. (NVO & OFF), 2129 NW., 79th Avenue, Doral, FL 33122... Individual) Akira Tsuneda, Director/COB. Application Type: QI Change. Contour Logistics Inc. (NVO & OFF... Energy & Marine Services LLC (NVO & OFF), 16607 Central Green Blvd., 200, Houston, TX 77032....

  19. 77 FR 50688 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-08-22

    ..., President. Application Type: QI Change. Transera International Logistics (OFF), 10343 Sam Houston Park Drive... telephone at (202) 523-5843 or by email at OTI@fmc.gov . Anselm K. Nwankwo dba Anze Global Logistics (NVO... Logistics Inc. (NVO & OFF), 288 West 238th Street 5h, Bronx, NY 10463. Officer: Angel N. Espinoza,...

  20. Quantum metrology and its application in biology

    OpenAIRE

    Taylor, Michael A.; Bowen, Warwick P.

    2014-01-01

    Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applicat...

  1. Palo Verde Generating Station, Units 4 and 5. License application, general information

    International Nuclear Information System (INIS)

    A license application for two more Palo Verde reactors, Units 4 and 5, is presented. The two PWR reactors have a nominal net generating power each of 1,270 MW(e). Containments are steel-lined prestressed cylindrical structures with hemispherical domes. The reactors are replicas of Palo Verde 1, 2 and 3 (see DOCKETS 50528, 50529 and 50530) using the standard Combustion Engineering System 80 (see DOCKET-STN-50470)

  2. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry. PMID:23502560

  3. 75 FR 29335 - Rumford Falls Hydro, LLC; Notice of Application for Amendment of License, and Soliciting Comments...

    Science.gov (United States)

    2010-05-25

    ... inspection: a. Type of Application: Amendment of License. b. Project No.: 2333-068. c. Date Filed: July 23... site located at http://ferc.gov .filing-comments.asp. Please include the project number (P-...

  4. Biological and Geographical application tool

    OpenAIRE

    Pereira, Miguel

    2007-01-01

    Monitoring and species identify is an essential step to natural resources management. Among these, biological resources aim special concern because data availability is highly limited by a number of sampling logistic constraints and catalog. As a matter of fact, data availability is one of important limitation to knowledge and, as a consequence the development of a new concept in natural resources. Data organization in digital format is a common practice in our days, and has the power to cont...

  5. 76 FR 81994 - UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit...

    Science.gov (United States)

    2011-12-29

    ... Commission (NRC or the Commission ) a Combined License (COL) Application for a single unit of AREVA NP's U.S... Calvert County, Maryland. The CCNPP3 COL application incorporates by reference AREVA NP's application for a Standard Design Certification for the U.S. EPR. The NRC docketed the CCNPP3 COL application...

  6. Aptamers and Their Biological Applications

    Directory of Open Access Journals (Sweden)

    Changill Ban

    2012-01-01

    Full Text Available Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-based selection methods, are explained in detail. We also introduce various applications of aptamers for the diagnosis of diseases and detection of small molecules. Numerous analytical techniques, such as electrochemical, colorimetric, optical, and mass-sensitive methods, can be utilized to detect targets, due to convenient modifications and the stability of aptamers. Finally, several medical and analytical applications of aptamers are presented. In summary, aptamers are promising materials for diverse areas, not just as alternatives to antibodies, but as the core components of medical and analytical equipment.

  7. Fluorescent Sensors for Biological Applications

    Directory of Open Access Journals (Sweden)

    Hui-wang Ai

    2014-09-01

    Full Text Available Fluorescence is one of the most important analytical methods used in biological studies. In the past decade or two, instrumentation in this field has greatly advanced, and now it is possible to detect single photons or fluorescent molecules [1,2], or break the Abbe diffraction limit to distinguish two points spaced less than 50 nm apart [3]. Concurrently, the development of improved fluorescent probes, which can be coupled with state-of-the-art instruments, has been equally important. This special issue on “fluorescent biosensors” in Sensors reports recent results from eight research groups in the field of sensor development. It includes three review articles, and six research articles reporting original results. [...

  8. Database Transformations for Biological Applications

    Energy Technology Data Exchange (ETDEWEB)

    Overton, C.; Davidson, S. B.; Buneman, P.; Tannen, V.

    2001-04-11

    The goal of this project was to develop tools to facilitate data transformations between heterogeneous data sources found throughout biomedical applications. Such transformations are necessary when sharing data between different groups working on related problems as well as when querying data spread over different databases, files and software analysis packages.

  9. Aptamers and Their Biological Applications

    OpenAIRE

    Changill Ban; Seonghwan Lee; Kyung-Mi Song

    2012-01-01

    Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-ba...

  10. Single nanoparticle detectors for biological applications

    Science.gov (United States)

    Yurt, Abdulkadir; Daaboul, George G.; Connor, John H.; Goldberg, Bennett B.; Selim Ünlü, M.

    2012-01-01

    Nanoparticle research has become increasingly important in the context of bioscience and biotechnology. Practical use of nanoparticles in biology has significantly advanced our understanding about biological processes in the nanoscale as well as led to many novel diagnostic and therapeutic applications. Besides, synthetic and natural nanoparticles are of concern for their potential adverse effect on human health. Development of novel detection and characterization tools for nanoparticles will impact a broad range of disciplines in biological research from nanomedicine to nanotoxicology. In this article, we discuss the recent progress and future directions in the area of single nanoparticle detectors with an emphasis on their biological applications. A brief critical overview of electrical and mechanical detection techniques is given and a more in-depth discussion of label-free optical detection techniques is presented.

  11. Mammalian synthetic biology: emerging medical applications

    OpenAIRE

    Kis, Zoltán; Pereira, Hugo Sant'Ana; Homma, Takayuki; Pedrigi, Ryan M.; Krams, Rob

    2015-01-01

    In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and tog...

  12. Single nanoparticle detectors for biological applications

    OpenAIRE

    Yurt, Abdulkadir; Daaboul, George G.; Connor, John H.; Goldberg, Bennett B.; Ünlü, M. Selim

    2012-01-01

    Nanoparticle research has become increasingly important in the context of bioscience and biotechnology. Practical use of nanoparticles in biology has significantly advanced our understanding about biological processes in the nanoscale as well as led to many novel diagnostic and therapeutic applications. Besides, synthetic and natural nanoparticles are of concern for their potential adverse effect on human health. Development of novel detection and characterization tools for nanoparticles will...

  13. Marine Carotenoids: Biological Functions and Commercial Applications

    OpenAIRE

    Vega, José M.; Inés Garbayo; Francisco Bédmar; María Cuaresma; Carlos Vílchez; Eduardo Forján

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesised by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functions of carotenoids relevant for life on earth. Biological properties of carotenoids allow for wide range of commercial applications. Indeed, recent interest in the carotenoids has be...

  14. Quantum metrology and its application in biology

    Science.gov (United States)

    Taylor, Michael A.; Bowen, Warwick P.

    2016-02-01

    Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artefacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient details to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science. We hope that this will aid in bridging the communication gap that exists

  15. 78 FR 75376 - Entergy Operations, Inc.; Combined License Application for River Bend Unit 3, Exemption From the...

    Science.gov (United States)

    2013-12-11

    ... Combined License (COL) application. The NRC staff reviewed this request and determined that it is... coincident with, the resumption of the COL application review or by December 31, 2014, whichever comes first... Background On September 25, 2008, EOI submitted to the NRC a COL application for one Economic...

  16. 78 FR 75379 - Entergy Operations, Inc.; Combined License Application for Grand Gulf Unit 3; Exemption From the...

    Science.gov (United States)

    2013-12-11

    ... Combined License (COL) application. The NRC staff reviewed this request and determined that it is... coincident with, the resumption of the COL application review or by December 31, 2014, whichever comes first... Background On February 27, 2008, EOI submitted to the NRC a COL application for one Economic...

  17. Biological applications of nanoscale materials

    Science.gov (United States)

    Liang, Chi-Hui

    2007-12-01

    The objective of my research work is to synthesize, characterize, design, and apply nanocrystals for biomedical use. Gold nanoparticles were synthesized in the presence of chitosan via reduction of HAuCl4 with sodium borohydride. The average particle size of gold nanoparticles was significantly affected with the concentration of chitosan added and was ranged between 5 and 30 nm. The gold-chitosan nanocomposites were formed by adsorbing chitosan molecules on the gold nanoparticles. CdSe/ZnS quantum dots were prepared by a solution phase synthetic method. A new route for the phase transfer of CdSe/ZnS quantum dots from non-polar solvents into aqueous solution was developed using hydrophobically modified polysaccharides, both chitosan and alginate. In addition, it was shown that CdSe/ZnS based polysaccharide nanoparticles effectively inhibited the proliferation of human ovarian cancer cell line SKOV-3 in vitro. The findings suggest that CdSe/ZnS quantum dot based polysaccharide nanoparticles not only act as a long-term biomarker but also have potential value in cancer therapy. A novel method for extracting magnetite nanoparticles from magnetotactic bacteria was developed by using co-surfactant. The problem of mass cultivation was solved by growing AMB-1 in Ca2+-alginate microbeads. To apply magnetotactic bacterial in biomedical applications, uptake of chitosan-capped CdSe/ZnS quantum dots on magnetotactic bacteria and introducing fluorescent magnetotactic bacteria into mouse macrophage cells was achieved. A general strategy is described which allows for constructing multifunctional magnetic nanocomposites based on bacterial magnetite nanoparticles. Specifically, core-shell structures of bacterial magnetite-CdSe ZnS and bacterial magnetite-gold nanocomplexes have been built in this way. Furthermore, design and synthesis multimodal contrast agents which are ultrasound and photoacoustic active are achieved by utilizing biocompatible gold nanorods self assembling on

  18. Application of molecular biology in exercise physiology.

    Science.gov (United States)

    Booth, F W

    1989-01-01

    Past progress in exercise biochemical research has often depended on the use of knowledge and techniques which were originally reported from other disciplines. With the advent of newer methodologies in molecular biology, the purpose of this review has been to document the status of information gained from the application of molecular biological techniques to questions in exercise physiology. Furthermore, this review has speculated how new methods in molecular biology might be employed to answer classic questions in exercise physiology. A powerful revolution in science, that is, molecular biology, will provide new information about exercise mechanisms, which ideally will improve the training programs for elite athletes as well as continue to be associated with the public's interest in exercise training.

  19. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  20. 76 FR 40904 - FPL Energy Maine Hydro LLC; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2011-07-12

    ... project's installed capacity from 83.7 MW to 85.2 MW and the hydraulic capacity would increase by 2.5... Application: Amendment of License. b. Project No: 2329-089. c. Date Filed: June 3, 2011. d. Applicant: FPL Energy Maine Hydro LLC. e. Name of Project: Wyman Project. f. Location: The project is located on...

  1. 78 FR 69402 - Lock 7 Hydro Partners, LLC; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2013-11-19

    .... Application Type: Amendment of License. b. Project No: 539-013. c. Date Filed: September 23, 2013. d. Applicant: Lock 7 Hydro Partners, LLC. e. Name of Project: Mother Ann Lee Hydroelectric Project. ] f... generating unit No. 2. The runner replacement would increase the installed and hydraulic capacities of...

  2. 78 FR 14842 - Crystal River Nuclear Generating Plant, Unit 3; Application for Renewal of License to Facility...

    Science.gov (United States)

    2013-03-07

    ... application in the Federal Register on March 9, 2009 (74 FR 10099). The FPC requested withdrawal of the... renewal, which was published in the Federal Register on June 3, 2011 (76 FR 32237). However, since the... COMMISSION Crystal River Nuclear Generating Plant, Unit 3; Application for Renewal of License to...

  3. Repository program licensing approach

    International Nuclear Information System (INIS)

    Yucca Mountain, Nevada is currently being studied by the US Department of Energy (DOE) as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to determine the suitability of the site and to develop a license application (LA) for authorization to construct the potential repository. If the site is suitable, the license application would be submitted to the US Nuclear Regulatory Commission (NRC). The repository program licensing approach is focused on the timely acquisition of information needed in licensing and the resolution of potential licensing issues with the NRC staff. Licensing involves an iterative process requiring refinements as data are acquired, analyzed, and evaluated. The repository licensing approach presented in this paper ensures that the information is available when needed to facilitate the licensing process. Identifying the information needed to evaluate compliance with the performance objectives in 10 CFR 60, monitoring the acquisition of such information, and developing a successful license application are integral elements of DOE's repository program licensing approach. Activities to characterize the site are being systematically conducted as planned in the Site Characterization Plan (SCP). In addition, DOE is implementing the issue resolution initiative, the license application annotated outline (LAAO) process, and interim licensability evaluations to update the early planning in the SCP and to focus site characterization, design, and performance assessment activities on the acquisition of information needed for a site suitability determination and licensing. Collectively, the issue resolution initiative, LAAO process, and interim licensability evaluations are key elements of a transition to the iterative process to answer the question: open-quotes When do we have enough data to support licensing?close quotes

  4. Porphyrin Microparticles for Biological and Biomedical Applications

    Science.gov (United States)

    Huynh, Elizabeth

    Lipids are one of the critical building blocks of life, forming the plasma membrane of cells. In addition, porphyrins also play an equally important role in life, for example, through carrying oxygen in blood. The importance of both these components is evident through the biological and biomedical applications of supramolecular structures generated from lipids and porphyrins. This thesis investigates new porphyrin microparticles based on porphyrin-lipid architecture and their potential applications in biology and medicine. In Chapter 1, a background on lipid and porphyrin-based supramolecular structures is presented and design considerations for generating multifunctional agents. Chapter 2 describes the generation of a monolayer porphyrin microparticle as a dual-modal ultrasound and photoacoustic contrast agent and subsequently, a trimodal ultrasound, photoacoustic and fluorescence contrast agent. Chapter 3 examines the optical and morphological response of these multimodality ultrasound-based contrast agents to low frequency, high duty cycle ultrasound that causes the porphyrin microparticles to convertinto nanoparticles. Chapter 4 examines the generation of bilayer micrometer-sized porphyrin vesicles and their properties. Chapter 5 presents a brief summary and potential future directions. Although these microscale structures are similar in structure, the applications of these structures greatly differ with potential applications in biology and also imaging and therapy of disease. This thesis aims to explore and demonstrate the potential of new simplified, supramolecular structures based on one main building block, porphyrin-lipid.

  5. Safety evaluation status report for the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the earth-mounded concrete bunker (EMCB) alternative method of low-level radioactive waste disposal. The NRC reviewers relied extensively on the Standard Review Plan (SRP), Rev.1 (NUREG-1200), to evaluate the acceptability of the information provided in the EMCB PLASAR. The NRC staff selected certain review areas in the PLASAR for development of safety evaluation report input to provide examples of safety assessments that are necessary as part of a licensing review. Because of the fictitious nature of the assumed disposal site, and the decision to limit the review to essentially first-round review status, the NRC staff report is labeled a ''Safety Evaluation Status Report'' (SESR). Appendix A comprises the NRC review comments and questions on the information that DOE submitted in the PLASAR. The NRC concentrated its review on the design and operations-related portions of the EMCB PLASAR

  6. Nanotechnology Applications for Chemical and Biological Sensors

    Directory of Open Access Journals (Sweden)

    M. K. Patra

    2008-09-01

    Full Text Available Recent discoveries indicate that when the materials are brought down to sizes in the range 1–100 nm, theseexhibit unique electrical, optical, magnetic, chemical, and mechanical properties. Methods have now beenestablished to obtain the monodisperse nanocrystals of various metallic and semiconducting materials, single-walled and multi-walled nanotubes of carbon and other metallic and non-metallic materials together withorganic nanomaterials such as supra-molecular nanostructures, dendrimers, hybrid composites with tailoredfunctionalities. The high surface-to-volume ratio with an added element of porosity makes these highly potentialcandidates for chemical and biological sensor applications with higher degree of sensitivity and selectivity ascompared to their bulk counterparts. The paper reviews the recent developments and applications of chemicaland biological sensors based on nanomaterials of various structural forms.Defence Science Journal, 2008, 58(5, pp.636-649, DOI:http://dx.doi.org/10.14429/dsj.58.1686

  7. Molecular biology applications to infectious diseases diagnostic

    International Nuclear Information System (INIS)

    This project goes directed to the applications of the techniques of molecular biology in hepatitis virus.A great advance of these techniques it allows its application to the diagnose molecular and it becomes indispensable to have these fundamental tools in the field of the Health Public for the detection precocious, pursuit of the treatment, the one predicts and the evolution of the patient hepatitis bearing virus technical.Use of molecular biology to increase the handling and the control of the patients with hepatitis B and C and to detect an adult numbers of positive cases by means of the training and integration of all the countries participating.Implement the technique of PCR to identify the virus of the hepatitis B and C,implement quantification methods and genotipification for these virus

  8. 21 CFR 610.53 - Dating periods for licensed biological products.

    Science.gov (United States)

    2010-04-01

    ... Vaccine Adsorbed ......do ......do Do. Plague Vaccine ......do ......do Do. Plasma products: 1. Fresh Frozen Plasma Not applicable ......do 1 year from date of collection of source blood (−18 °C or colder). 2. Liquid Plasma ......do ......do (a) 26 days from date of collection of source blood (between...

  9. Machine Learning for Biological Trajectory Classification Applications

    Science.gov (United States)

    Sbalzarini, Ivo F.; Theriot, Julie; Koumoutsakos, Petros

    2002-01-01

    Machine-learning techniques, including clustering algorithms, support vector machines and hidden Markov models, are applied to the task of classifying trajectories of moving keratocyte cells. The different algorithms axe compared to each other as well as to expert and non-expert test persons, using concepts from signal-detection theory. The algorithms performed very well as compared to humans, suggesting a robust tool for trajectory classification in biological applications.

  10. 75 FR 39668 - Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-07-12

    ..., revocable license for the field of shigella vaccine development to U.S. Patent Application No. 11/727,486 entitled ``Artificial Invaplex,'' filed March 27, 2007, and related foreign patent applications (PCT/US2007... Department of the Army Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned...

  11. Current regulatory and licensing status for byproduct sources, facilities and applications

    International Nuclear Information System (INIS)

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig

  12. Biological basis of beam application in biotechnology

    International Nuclear Information System (INIS)

    Heavy particle beams have relatively high value of linear energy transfer (LET), and relative biological effectiveness (RBE). There is a sharp increase in ionization density (LET) in the so-called Bragg peak, close to the end of each track. The LET and RBE may, therefore, be high at the distal edge of the biological target volume. It is well-known that as the LET is increased beyond about 30 keV/um the RBE increases to a peak at 100 to 110 keV/um and then falls. At the same time the oxygen-enhancement ratio (OER) decreases steadily. The reason of these events has a greater chance per unit dose of depositing a certain minimum energy of about 300 eV, that is, 10 to 15 ionizations into each biological target volume of 5 to 10 nm diameter. These biological targets may be pictured as double strands of DNA and histones, 2 or 3 nm in diameter, with a surrounding water sheath of a few nm thick. The drop of RBE with increasing LET past the peak of RBE is due to either overkill or the recombinations of electrons and ions and of chemical radicals in the higher LET track. Large new accelerators have allowed the effects of heavy particle irradiation to be investigated. In biotechnology, radiation methods have found application as tools to explore some basic problems and this aspect of radiation research is likely to expand in the future. (author)

  13. 78 FR 26768 - Great Lakes Hydro America, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2013-05-08

    ... Energy Regulatory Commission Great Lakes Hydro America, LLC; Notice of Intent To File License Application...-filing Process. b. Project No.: 2520-072. c. Dated Filed: March 1, 2013. d. Submitted By: Great Lakes... designating Great Lakes Hydro America, LLC as the Commission's non-federal representative for carrying...

  14. 76 FR 81992 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2011-12-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption 1.0..., Certifications, and Approvals for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend...

  15. 78 FR 5505 - Turkey Point, Units 3 and 4; Application and Amendment to Facility Operating License Involving...

    Science.gov (United States)

    2013-01-25

    ... accordance with the NRC's E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires... COMMISSION Turkey Point, Units 3 and 4; Application and Amendment to Facility Operating License Involving... Turkey Point plant located in Miami-Dade County, Florida. The proposed amendments would reduce...

  16. 76 FR 38177 - Falcon Shipping Inc., Abdiel Falcon-Application for a License as an Ocean Transportation...

    Science.gov (United States)

    2011-06-29

    ... Falcon Shipping Inc., Abdiel Falcon--Application for a License as an Ocean Transportation Intermediary Order To Show Cause Falcon Shipping Inc. (Falcon Shipping) and Mr. Abdiel Falcon submitted an...) on March 8, 2011. Incorporated in Florida on February 18, 2008, Falcon Shipping is currently...

  17. 77 FR 35079 - License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC

    Science.gov (United States)

    2012-06-12

    .... Address questions about NRC dockets to Carol Gallagher; telephone: 301-492- 3668; email: Carol.Gallagher... INFORMATION CONTACT: Mr. Michael Wentzel, Division of License Renewal, Office of Nuclear Reactor Regulation, U...: michael.wentzel@nrc.gov . SUPPLEMENTARY INFORMATION: Discussion NextEra submitted an application...

  18. 78 FR 4467 - UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3...

    Science.gov (United States)

    2013-01-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3, Exemption 1.0 Background UniStar Nuclear Energy (UNE), on behalf of Calvert Cliffs Nuclear Project, LLC...

  19. 76 FR 11522 - In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear...

    Science.gov (United States)

    2011-03-02

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear... relating to pending appeal filed by the Nuclear Regulatory Commission staff in this case. Mr. Dehmel...

  20. Tomographic phase microscopy and its biological applications

    Science.gov (United States)

    Choi, Wonshik

    2012-12-01

    Conventional interferometric microscopy techniques such as digital holographic microscopy and quantitative phase microscopy are often classified as 3D imaging techniques because a recorded complex field image can be numerically propagated to a different depth. In a strict sense, however, a single complex field image contains only 2D information on a specimen. The measured 2D image is only a subset of the 3D structure. For the 3D mapping of an object, multiple independent 2D images are to be taken, for example at multiple incident angles or wavelengths, and then combined by the so-called optical diffraction tomography (ODT). In this Letter, tomographic phase microscopy (TPM) is reviewed that experimentally realizes the concept of the ODT for the 3D mapping of biological cells in their native state, and some of its interesting biological and biomedical applications are introduced. [Figure not available: see fulltext.

  1. Optical fibre cantilever sensor for biological application

    Science.gov (United States)

    Li, J.; Zhou, Y. X.; Patterson, G.; Shu, W. M.; Maier, R. R. J.; Fowler, R.; Hand, D. P.; MacPherson, W. N.

    2014-05-01

    Micro-cantilever sensors have shown great promise in a wide range of application are as including chemical and biological sensing. However, many of these devices are based upon a sensor `chip' that requires careful alignment between the cantilever and the read-out system, which can be challenging. Furthermore, optical interrogation typically involves a bulky free-space system. Optical fibre addressed cantilevers have been reported previously in the literature and in this paper we propose techniques to design and fabricate polymer micro-cantilevers for attachment onto the end of standard single mode fibres using laser machining. Low-cost optical sources and a fibre coupled spectrometer are employed to monitor the cantilever deflection and therefore observe biological binding between a species of interest and an activated cantilever. Proof-of-concept experiments show that the sensor is capable of detecting pathogen concentration with down to a level of 105cfu/ml.

  2. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  3. Applicability of IBAMA normative instruction 146-2007 to pipeline environmental licensing

    Energy Technology Data Exchange (ETDEWEB)

    Basbaum, Marcos A.; Fonseca, Renata A.A. [Servicos de Engenharia Emilio Baumgart Ltda. (SEEBLA), Rio de Janeiro, RJ(Brazil)], e-mail: mbasbaum.seebla@petrobras.com.br, e-mail: renataamorim.seebla@petrobras.com.br; Torggler, Bianca F.; Fernandes, Renato; Guimaraes, Ricardo Z.P. [Petroleo do Brasil S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)], e-mail: torggler@petrobras.com.br, e-mail: renatofer@petrobras.com.br, e-mail: rzaluar@petrobras.com.br

    2009-07-01

    PETROBRAS has been conducting several wildlife programs in response to environmental licensing requirements from IBAMA (Brazilian environmental agency). Since 2007, IBAMA has been requiring the application of the Normative Instruction n. 146 (NI), which establishes criteria for wildlife management in the influence areas of new enterprises. However, experience from PETROBRAS has shown that many of the NI articles are not applicable to pipelines. Thus, a critical analysis of this NI was done based on data from company's wildlife programs. Our analysis indicated that the main NI items that do not apply to pipelines are: 1 - Animal rescue programs in deforested areas and selection of release areas, 2 - More than two fauna monitoring campaigns a year, 3 - Monitoring programs involving all groups of terrestrial vertebrates and also invertebrate classes. The non-applicability of these items is due to: 1 - The majority of pipelines are built in areas without significant native vegetation or with small fragments only, which are usually in secondary stage of ecological succession. Most pipelines scarcely involve removal of primary vegetation, 2 - Pipelines have an influence area restricted to a range of 800 m and the construction directly affects only strips from 20 m to 30 m, 3 - The most relevant impacts associated with pipelines are temporary, and do not persist during their operation. (author)

  4. Methodology of licensing for field applications of Weld Inlay and Ultrasonic Nanocrystal Surface Modification

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hong Seok; Jung, Kwang Woon [KEPCO KPS, Naju (Korea, Republic of); Park, Ik Keun [Seoul National Univ, Seoul (Korea, Republic of); Pyun, Young Sik [Sun Moon University, Asan (Korea, Republic of)

    2015-10-15

    There are many attempts to relieve or change high tensile residual stress to compressive residual stress for a mitigation of PWSCC. LSP(Laser Shot Peening) and WJP(Water Jet Peening) have been applied in several NPPs of Japan and technical and topical reports under Materials Reliability Program of EPRI(Electric Power Research Institute ) USA have been developed. Weld Inlay technology and UNSM(Ultrasonic Nanocrystal Surface Modification) technology using ultrasonic vibration energy as the method for a mitigation of tensile residual stress generated after Weld Inlay have been developing in Korea. So in this study, the methodology of licensing for field application of these technologies is suggested. The results of residual stress measured before and after UNSM for Weld Inlay specimens using UNSM equipment of domestic source technology holdings to obtain an equivalent effect, which has the simplification of equipment and the flexibility of field application in comparison with LSP and WJP, indicated to obtain a mitigation effect of residual stress until 0.5 mm of surface depth. In order to accomplish field application of Weld Inlay that the Code Case was already developed, the approval of a regulation agency through the preparation of TR or RR based on ASME Code Case N-766, N-803 is necessary.

  5. 22 CFR 96.30 - State licensing.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false State licensing. 96.30 Section 96.30 Foreign... Licensing and Corporate Governance § 96.30 State licensing. (a) The agency or person is properly licensed or... person follows applicable State licensing and regulatory requirements in all jurisdictions in which...

  6. 9 CFR 102.6 - Conditional licenses.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL...) of this part, issue a conditional U.S. Veterinary Biological Product License to an establishment... available, the Administrator shall either reissue the U.S. Veterinary Biological Product License or allow...

  7. Radio-analysis. Applications: biological dosimetry; Radioanalyse. Applications: dosage biologique

    Energy Technology Data Exchange (ETDEWEB)

    Bourrel, F. [CEA Saclay, INSTN, Institut National des Sciences et Techniques Nucleaires, 91 - Gif-sur-Yvette (France); Courriere, Ph. [UFR de Pharmacie, 31 - Toulouse (France)

    2003-06-01

    Radioisotopes have revolutionized the medical biology. Radio-immunology remains the reference measurement of the infinitely small in biology. Constant efforts have been performed to improve the simpleness, detectability and fastness of the method thanks to an increasing automation. This paper presents: 1 - the advantages of compounds labelling and the isotopic dilution; 2 - the antigen-antibody system: properties, determination of the affinity constant using the Scatchard method; 3 - radio-immunologic dosimetry: competitive dosimetry (radioimmunoassay), calibration curve and mathematical data processing, application to the free thyroxine dosimetry, immunoradiometric dosimetry (immunoradiometric assay), evaluation of the analytical efficiency of a radioimmunoassay; 4 - detection of the radioactive signal (solid and liquid scintillation). (J.S.)

  8. PIXE and its applications to biological samples

    International Nuclear Information System (INIS)

    Throughout this century, industrialized society has seriously affected the ecology by introducing huge amounts of pollutants into the atmosphere as well as marine and soil environments. On the other hand, it is known that these pollutants, in excess of certain levels of concentration, not only put at risk the life of living beings but may also cause the extinction of some species. It is therefore of basic importance to substantially increase quantitative determinations of trace element concentrations in biological specimens in order to assess the effects of pollutants. It is in this field that PIXE plays a key role in these studies, where its unique analytical properties are decisive. Moreover, since the importance of these research has been recognized in many countries, many scientists have been encouraged to continue or initiate new research programmes aimed to solve the worldwide pollution problem. This document presents an overview of those papers reporting the application of PIXE analysis to biological samples during this last decade of the 20th century and recounts the number of PIXE laboratories dedicating their efforts to find the clues of the biological effects of the presence of pollutants introduced in living beings. Sample preparation methods, different kinds of samples under study and the use of complementary analytical techniques are also illustrated. (author). 108 refs

  9. RNA interference - From Biology to clinical applications

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-12-01

    Full Text Available I strongly advice the readers to go to the Nobel foundation web site and read the Nobel lectures by Andrew Z. Fire and Craig C. Mello, the two 2006 Nobel laureates "for their discovery of RNA interference - gene silencing by double-stranded RNA" (http://nobelprize.org/nobel_prizes/medicine/laureates/2006/. Well, it is impressive how both the Nobel laureates clearly anticipate the immense possibility the phenomenon they discovered is giving to Biology and its applications. That is to say, they clearly visioned the great chance to both advance our theoretical understanding of gene expression regulation (i.e., how the gene networks and circuiteries are finely tuned by RNA interference, and its critical role in ontogeny and make use in biotechnological applications of this formidable tool, notably in translational medicine. Here we go to the............

  10. 75 FR 62592 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2010-10-12

    ... amendments to the Renewed Facility Operating Licenses include: (1) The proposed Cyber Security Plan for CCNPP... implement and maintain in effect all provisions of the Nuclear Regulatory Commission-approved Cyber Security... cyber security program. This regulation specifically requires each licensee currently licensed...

  11. FCC Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and...

  12. Oligothiophenes as Fluorescent Markers for Biological Applications

    Directory of Open Access Journals (Sweden)

    Antonio Manetto

    2012-01-01

    Full Text Available This paper summarizes some of our results on the application of oligothiophenes as fluorescent markers for biological studies. The oligomers of thiophene, widely known for their semiconductor properties in organic electronics, are also fluorescent compounds characterized by chemical and optical stability, high absorbance and quantum yield. Their fluorescent emission can be easily modulated via organic synthesis by changing the number of thiophene rings and the nature of side-chains. This review shows how oligothiophenes can be derivatized with active groups such as phosphoramidite, N-hydroxysuccinimidyl and 4-sulfotetrafluorophenyl esters, isothiocyanate and azide by which the (biomolecules of interest can be covalently bound. This paper also describes how molecules such as oligonucleotides, proteins and even nanoparticles, tagged with oligothiophenes, can be used in experiments ranging from hybridization studies to imaging of fixed and living cells. Finally, a few multilabeling experiments are described.

  13. Application of Graph Coloring to Biological Networks

    CERN Document Server

    Khor, Susan

    2009-01-01

    We explore the application of graph coloring to biological networks, specifically protein-protein interaction (PPI) networks. First, we find that given similar conditions (i.e. number of nodes, number of links, degree distribution and clustering), fewer colors are needed to color disassortative (high degree nodes tend to connect to low degree nodes and vice versa) than assortative networks. Fewer colors create fewer independent sets which in turn imply higher concurrency potential for a network. Since PPI networks tend to be disassortative, we suggest that in addition to functional specificity and stability proposed previously by Maslov and Sneppen (Science 296, 2002), the disassortative nature of PPI networks may promote the ability of cells to perform multiple, crucial and functionally diverse tasks concurrently. Second, since graph coloring is closely related to the presence of cliques in a graph, the significance of node coloring information to the problem of identifying protein complexes, i.e. dense subg...

  14. Flavonoids: Biosynthesis, Biological functions and Biotechnological applications

    Directory of Open Access Journals (Sweden)

    Maria Lorena eFalcone Ferreyra

    2012-09-01

    Full Text Available Flavonoids are widely distributed secondary metabolites with different metabolic functions in plants. The elucidation of the biosynthetic pathways, as well as their regulation by MYB, bHLH and WD40-type transcription factors, has allowed metabolic engineering of plants through the manipulation of the different final products with valuable applications. The present review describes the regulation of flavonoid biosynthesis, as well as the biological functions of flavonoids in plants, such as in defense against UV-B radiation and pathogen infection, nodulation, pollen fertility. In addition, we discuss different strategies and achievements through the genetic engineering of flavonoid biosynthesis with implication in the industry and the combinatorial biosynthesis in microorganisms by the reconstruction of the pathway to obtain high amounts of specific compounds.

  15. How a regulator is preparing for reviewing a license application file: The case of ASN

    International Nuclear Information System (INIS)

    The French Nuclear Safety Authority (ASN) is an independent administrative authority. It prepares regulation pertaining to the management of radioactive waste, monitors the control of safety of basic nuclear installations that produce or treat waste or are involved in their disposal and performs inspections of waste producers (EDF, AREVA, CEA, hospitals, research centres, etc.) and Andra, the French National Radioactive Waste Management Agency. It regulates the overall system set up by Andra for accepting waste from producers and assesses waste management policy and the practices of radioactive waste producers. It reviews license applications and authorises commissioning of nuclear installations. In order to review technical documents, ASN benefits from the expertise of technical support organisations. The French Institute for Radiation Protection and Nuclear Safety (IRSN) is the main such organisation. ASN has been making efforts to diversify its experts for several years. In preparing its decisions, ASN also calls on the opinions and recommendations of seven Advisory Committees of Experts (GPE), with expert knowledge in the areas of waste, nuclear pressure equipment, medical exposure, non-medical radiation protection, reactors, transport, and laboratories and nuclear plants. ASN consults the GPEs in preparing its main decisions. In particular, they review the preliminary, provisional and final safety analysis reports for each nuclear installation. They can also be consulted about changes in regulations or doctrine. (authors)

  16. 78 FR 42798 - Notice of Invitation To Participate; Coal Exploration License Application WYW182164, WY

    Science.gov (United States)

    2013-07-17

    ... published in the Rock Springs Rocket-Miner once each week for 2 consecutive weeks beginning the week of July... exploration license on public land east of the Jim Bridger power plant and coal mine. The purpose of...

  17. 78 FR 37234 - Notice of Invitation; Coal Exploration License Application NDM 105349, ND

    Science.gov (United States)

    2013-06-20

    ... Office, 5001 Southgate Drive, Billings, Montana. A written notice to participate in the exploration license should be sent to the State Director, BLM Montana State Office, 5001 Southgate Drive, Billings, MT.... BILLING CODE 4310-DN-P...

  18. Graphene for Environmental and Biological Applications

    Science.gov (United States)

    Sreeprasad, T. S.; Pradeep, T.

    2012-08-01

    The latest addition to the nanocarbon family, graphene, has been proclaimed to be the material of the century. Its peculiar band structure, extraordinary thermal and electronic conductance and room temperature quantum Hall effect have all been used for various applications in diverse fields ranging from catalysis to electronics. The difficulty to synthesize graphene in bulk quantities was a limiting factor of it being utilized in several fields. Advent of chemical processes and self-assembly approaches for the synthesis of graphene analogues have opened-up new avenues for graphene based materials. The high surface area and rich abundance of functional groups present make chemically synthesized graphene (generally known as graphene oxide (GO) and reduced graphene oxide (RGO) or chemically converted graphene) an attracting candidate in biotechnology and environmental remediation. By functionalizing graphene with specific molecules, the properties of graphene can be tuned to suite applications such as sensing, drug delivery or cellular imaging. Graphene with its high surface area can act as a good adsorbent for pollutant removal. Graphene either alone or in combination with other materials can be used for the degradation or removal of a large variety of contaminants through several methods. In this review some of the relevant efforts undertaken to utilize graphene in biology, sensing and water purification are described. Most recent efforts have been given precedence over older works, although certain specific important examples of the past are also mentioned.

  19. 7 CFR 868.81 - Licensing procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Licensing procedures. 868.81 Section 868.81 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD....81 Licensing procedures. (a) Application. An application for a license, the renewal of a license,...

  20. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  1. Biological fuel cells and their applications

    OpenAIRE

    Shukla, AK; Suresh, P; Berchmans, S; Rajendran, A.

    2004-01-01

    One type of genuine fuel cell that does hold promise in the long-term is the biological fuel cell. Unlike conventional fuel cells, which employ hydrogen, ethanol and methanol as fuel, biological fuel cells use organic products produced by metabolic processes or use organic electron donors utilized in the growth processes as fuels for current generation. A distinctive feature of biological fuel cells is that the electrode reactions are controlled by biocatalysts, i.e. the biological redox-reac...

  2. Facilities license application record data as of April 1, 1981. Tri-annual report 30 Nov 80-1 Apr 81

    International Nuclear Information System (INIS)

    The FLAR is divided into three parts as follows: Part I - The first part is a listing of all operating licenses, authorizations and construction permits in effect plus applications pending; Part II - The second part is a listing of applications that have been withdrawn or denied, and licenses and construction permits terminated or revoked; and Part III - The third part is a listing of research, test and power reactors for export

  3. Contestable Licensing

    OpenAIRE

    Zvika Neeman

    2000-01-01

    We analyze a model of (repeated) franchise bidding for natural monopoly that relies on contestable licensing -- the right to operate the franchise belongs to the party who owns the appropriate license as long as the license is not successfully contested through a process of competitive bidding -- and demonstrate the usefulness of contestable licensing in inducing high quality performance from incumbent franchisees. In a world where quality is observable but not verifiable, the simple regulato...

  4. OpenCV在车牌识别中的应用%Application of OpenCV in License Plate Recognition

    Institute of Scientific and Technical Information of China (English)

    姜莉莉; 蒋潇; 陈昕怡; 殷旭东

    2014-01-01

    For license plate recognition on smart phone, application of OpenCV is studied. First, OpenCV and work flow of license plate recognition are introduced. Then detailed application of OpenCV is discussed, which is in license plate location, character segmentation and character recognition. Experimental results show that the recognition is good. The foundation is laid for further developing a vehicle information management system on smart phones such as Android.%为利用智能手机进行车牌识别,研究了OpenCV在车牌识别中的应用。首先介绍了OpenCV及车牌识别的工作流程,然后论述了OpenCV在车牌定位、字符分割和字符识别中的具体应用。实验结果表明识别效果良好,为在Android等智能手机上进一步开发车辆信息管理系统奠定了基础。

  5. 78 FR 35273 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

    Science.gov (United States)

    2013-06-12

    ... new biological products contain data that are adequate to assess the safety and effectiveness of the... and advertisements for biological products as well as for prescription drugs and antibiotics. The... Service Act (42 U.S.C. 262), manufacturers of biological products must submit a license application...

  6. Detector applications in medecine and biology

    CERN Document Server

    Del Guerra, Alberto

    1995-01-01

    In recent years new diagnostic and therapeutic methods have been attracting more and more dedicated attention by the scientific community.The goal is a better understanding of the anatomy, physiology and pathology of the human being in an effort to find more appropriate medical prevention, diagnosis and therapy.Many of the achievements obtained so far derive from the use and the optimisation of detectors and techniques,which originated in the other fields of physics. The spin-off of High Energy Physics to Medical Physics has been particularly relevant in the field of detectors for medical imaging and especially for medical imaging with ionizing radiation. In this series of lectures,starting from the requests of each technique and or application I will attempt to present a survey of the detectors for medecine and biology. Various fields of medical imaging will be touched : radiology,digital radiography,mammography and radiotherapy. The capabilities of the major types of detectors (1-D and 2-D position sensitiv...

  7. Monovalent plasmonic nanoparticles for biological applications

    Science.gov (United States)

    Seo, Daeha; Lee, Hyunjung; Lee, Jung-uk; Haas, Thomas J.; Jun, Young-wook

    2016-03-01

    The multivalent nature of commercial nanoparticle imaging agents and the difficulties associated with producing monovalent nanoparticles challenge their use in biology, where clustering of target biomolecules can perturb dynamics of biomolecular targets. Here, we report production and purification of monovalent gold and silver nanoparticles for their single molecule imaging application. We first synthesized DNA-conjugated 20 nm and 40 nm gold and silver nanoparticles via conventional metal-thiol chemistry, yielding nanoparticles with mixed valency. By employing an anion-exchange high performance liquid chromatography (AE-HPLC) method, we purified monovalent nanoparticles from the mixtures. To allow efficient peak-separation resolution while keeping the excellent colloidal stability of nanoparticles against harsh purification condition (e.g. high NaCl), we optimized surface properties of nanoparticles by modulating surface functional groups. We characterized the monovalent character of the purified nanoparticles by hybridizing two complementary conjugates, forming dimers. Finally, we demonstrate the use of the monovalent plasmonic nanoprobes as single molecule imaging probes by tracking single TrkA receptors diffusing on the cell membrane and compare to monovalent quantum dot probes.

  8. Information theory applications for biological sequence analysis.

    Science.gov (United States)

    Vinga, Susana

    2014-05-01

    Information theory (IT) addresses the analysis of communication systems and has been widely applied in molecular biology. In particular, alignment-free sequence analysis and comparison greatly benefited from concepts derived from IT, such as entropy and mutual information. This review covers several aspects of IT applications, ranging from genome global analysis and comparison, including block-entropy estimation and resolution-free metrics based on iterative maps, to local analysis, comprising the classification of motifs, prediction of transcription factor binding sites and sequence characterization based on linguistic complexity and entropic profiles. IT has also been applied to high-level correlations that combine DNA, RNA or protein features with sequence-independent properties, such as gene mapping and phenotype analysis, and has also provided models based on communication systems theory to describe information transmission channels at the cell level and also during evolutionary processes. While not exhaustive, this review attempts to categorize existing methods and to indicate their relation with broader transversal topics such as genomic signatures, data compression and complexity, time series analysis and phylogenetic classification, providing a resource for future developments in this promising area.

  9. Application of graph colouring to biological networks.

    Science.gov (United States)

    Khor, S

    2010-05-01

    The author explores the application of graph colouring to biological networks, specifically protein-protein interaction (PPI) networks. First, the author finds that given similar conditions (i.e. graph size, degree distribution and clustering), fewer colours are needed to colour disassortative than assortative networks. Fewer colours create fewer independent sets which in turn imply higher concurrency potential for a network. Since PPI networks tend to be disassortative, the author suggests that in addition to functional specificity and stability proposed previously by Maslov and Sneppen (Science, 296, 2002), the disassortative nature of PPI networks may promote the ability of cells to perform multiple, crucial and functionally diverse tasks concurrently. Second, because graph colouring is closely related to the presence of cliques in a graph, the significance of node colouring information to the problem of identifying protein complexes (dense subgraphs in PPI networks), is investigated. The author finds that for PPI networks where 1-11% of nodes participate in at least one identified protein complex, such as H. sapien, DSATUR (a well-known complete graph colouring algorithm) node colouring information can improve the quality (homogeneity and separation) of initial candidate complexes. This finding may help improve existing protein complex detection methods, and/or suggest new methods. [Includes supplementary material]. PMID:20499999

  10. Applicability of Item Response Theory to the Korean Nurses' Licensing Examination

    Directory of Open Access Journals (Sweden)

    Geum-Hee Jeong

    2005-06-01

    Full Text Available To test the applicability of item response theory (IRT to the Korean Nurses' Licensing Examination (KNLE, item analysis was performed after testing the unidimensionality and goodness-of-fit. The results were compared with those based on classical test theory. The results of the 330-item KNLE administered to 12,024 examinees in January 2004 were analyzed. Unidimensionality was tested using DETECT and the goodness-of-fit was tested using WINSTEPS for the Rasch model and Bilog-MG for the two-parameter logistic model. Item analysis and ability estimation were done using WINSTEPS. Using DETECT, Dmax ranged from 0.1 to 0.23 for each subject. The mean square value of the infit and outfit values of all items using WINSTEPS ranged from 0.1 to 1.5, except for one item in pediatric nursing, which scored 1.53. Of the 330 items, 218 (42.7% were misfit using the two-parameter logistic model of Bilog-MG. The correlation coefficients between the difficulty parameter using the Rasch model and the difficulty index from classical test theory ranged from 0.9039 to 0.9699. The correlation between the ability parameter using the Rasch model and the total score from classical test theory ranged from 0.9776 to 0.9984. Therefore, the results of the KNLE fit unidimensionality and goodness-of-fit for the Rasch model. The KNLE should be a good sample for analysis according to the IRT Rasch model, so further research using IRT is possible.

  11. Applicability of Computational Systems Biology in Toxicology

    DEFF Research Database (Denmark)

    Kongsbak, Kristine Grønning; Hadrup, Niels; Audouze, Karine Marie Laure;

    2014-01-01

    be used to establish hypotheses on links between the chemical and human diseases. Such information can also be applied for designing more intelligent animal/cell experiments that can test the established hypotheses. Here, we describe how and why to apply an integrative systems biology method......Systems biology as a research field has emerged within the last few decades. Systems biology, often defined as the antithesis of the reductionist approach, integrates information about individual components of a biological system. In integrative systems biology, large data sets from various sources...... and databases are used to model and predict effects of chemicals on, for instance, human health. In toxicology, computational systems biology enables identification of important pathways and molecules from large data sets; tasks that can be extremely laborious when performed by a classical literature search...

  12. Neutron Scattering in Biology Techniques and Applications

    CERN Document Server

    Fitter, Jörg; Katsaras, John

    2006-01-01

    The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

  13. Review of biological network data and its applications.

    Science.gov (United States)

    Yu, Donghyeon; Kim, Minsoo; Xiao, Guanghua; Hwang, Tae Hyun

    2013-12-01

    Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.

  14. Biological Applications in the Mathematics Curriculum

    Science.gov (United States)

    Marland, Eric; Palmer, Katrina M.; Salinas, Rene A.

    2008-01-01

    In this article we provide two detailed examples of how we incorporate biological examples into two mathematics courses: Linear Algebra and Ordinary Differential Equations. We use Leslie matrix models to demonstrate the biological properties of eigenvalues and eigenvectors. For Ordinary Differential Equations, we show how using a logistic growth…

  15. Applications in computer-assisted biology

    NARCIS (Netherlands)

    Nijveen, H.

    2013-01-01

    Biology is becoming a data-rich science driven by the development of high-throughput technologies like next-generation DNA sequencing. This is fundamentally changing biological research. The genome sequences of many species are becoming available, as well as the genetic variation within a species, a

  16. 75 FR 30440 - Biweekly Notice: Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-06-01

    ... (75 FR 27825). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... the probability or consequences of any previously evaluated accident, EGC did not consider the...

  17. 75 FR 44020 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-07-27

    ... material in addition to the boron carbide control rod material. Basis for proposed no significant hazards..., 2010 (75 FR 39975). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process...

  18. 76 FR 77565 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-12-13

    ...), Section Xl, Boiler and Pressure Vessel Code,] the Maintenance Rule, and Licensing commitments serve to... November 29, 2011 (76 FR 73727). ADDRESSES: Please include Docket ID NRC-2011-0285 in the subject line of... be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The...

  19. 75 FR 1655 - Biweekly Notice Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-01-12

    ... on December 29, 2009 (74 FR 68867). Notice of Issuance of Amendments to Facility Operating Licenses... Testing Program,'' contains references to the American Society of Mechanical Engineers (ASME) Boiler and... incorporated references to the ASME Code for Operation and Maintenance of Nuclear Power Plants (ASME OM...

  20. 75 FR 33839 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-06-15

    ...) surveillance requirement (SR) 3.1.4.3 is not required for control rod drive 22 through cycle 21 or until the..., 2010 (75 FR 30440). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process...

  1. 77 FR 3508 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2012-01-24

    ... Assemblies,'' to permit the use of AREVA's M5 advanced alloy for fuel rod cladding and fuel assembly..., Director, Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE 7590... From the Federal Register Online via the Government Publishing Office NUCLEAR...

  2. 76 FR 71082 - Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License Application...

    Science.gov (United States)

    2011-11-16

    ...), and opportunity to request a hearing was published in the Federal Register on July 13, 2011 (76 FR..., 2011 (76 FR 41308). One request for hearing was received on October 27, 2011. The NRC is preparing a... COMMISSION Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License...

  3. 21 CFR 515.21 - Refusal to approve a medicated feed mill license application.

    Science.gov (United States)

    2010-04-01

    ... animal feed are not adequate to preserve the identity, strength, quality, and purity of the new animal drug therein; or (3) The facility manufactures animal feeds bearing or containing new animal drugs in a... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE...

  4. 75 FR 52039 - Biweekly Notice Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-08-24

    ... Delta Temperature High Trip Setpoint and Allowable Value listed in Table 3.3.2-2, Isolation Actuation... Coolant Injection (HPCI) Equipment Room Delta Temperature High Isolation Trip Setpoint from http://www.nrc..., Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE 7590-01-P...

  5. 77 FR 6144 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2012-02-07

    ... modify TS Table 3.3.6.1-1, items; 1.e, ``Main Steam Tunnel Temperature-High,'' 3.f. ``Main Steam Line Tunnel Ambient Temperature-High,'' and 4.h, ``Main Steam Line Tunnel Ambient Temperature-High.'' This... of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE 7590-01-P...

  6. 78 FR 22576 - Application and Amendment to Facility Operating License Involving Proposed No Significant Hazards...

    Science.gov (United States)

    2013-04-16

    ... steady state full power operation'' shall be based upon the steam generators being operated under... operation of the steam generators nor introduce any changes to existing design functions of systems... temporary change to the steam generator management program and the license condition for maximum power....

  7. 75 FR 39975 - Applications and Amendments to Facility Operating Licenses Involving No Significant Hazards...

    Science.gov (United States)

    2010-07-13

    ... mode of plant operation and does not involve a physical modification to the plant. The change will not... Technical Specification (TS) 5.5.9 to exclude portions of the Steam Generator (SG) tube from periodic SG... FR 37471). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses,...

  8. 政府数据开放许可适用研究%Research on the Application of Open Data License for the Government

    Institute of Scientific and Technical Information of China (English)

    迪莉娅

    2014-01-01

    The application of open data license plays an important role in promoting to open and use government data.The paper presents the types of open data licenses, analyzing the application conditions of foreign government open data license, and dis-cussing the important significances and strategies of establishing government open data license of China.%数据开放许可的应用对促进政府数据开放和利用具有重要的作用。文章阐述了开放数据许可的类型,分析了国外政府数据开放许可适用情况,并探讨了建立我国政府数据开放许可的重要性和策略。

  9. Applicability of computational systems biology in toxicology.

    Science.gov (United States)

    Kongsbak, Kristine; Hadrup, Niels; Audouze, Karine; Vinggaard, Anne Marie

    2014-07-01

    Systems biology as a research field has emerged within the last few decades. Systems biology, often defined as the antithesis of the reductionist approach, integrates information about individual components of a biological system. In integrative systems biology, large data sets from various sources and databases are used to model and predict effects of chemicals on, for instance, human health. In toxicology, computational systems biology enables identification of important pathways and molecules from large data sets; tasks that can be extremely laborious when performed by a classical literature search. However, computational systems biology offers more advantages than providing a high-throughput literature search; it may form the basis for establishment of hypotheses on potential links between environmental chemicals and human diseases, which would be very difficult to establish experimentally. This is possible due to the existence of comprehensive databases containing information on networks of human protein-protein interactions and protein-disease associations. Experimentally determined targets of the specific chemical of interest can be fed into these networks to obtain additional information that can be used to establish hypotheses on links between the chemical and human diseases. Such information can also be applied for designing more intelligent animal/cell experiments that can test the established hypotheses. Here, we describe how and why to apply an integrative systems biology method in the hypothesis-generating phase of toxicological research.

  10. Proceedings of biological applications of relativistic nuclei

    International Nuclear Information System (INIS)

    The workshop BARN 92 on various aspects of radiation treatment of tumours and of biological radiation effects on living system hosted 38 short papers. Each is indexed and abstracted separately for the INIS database. (R.P.)

  11. Structural Biology and Molecular Applications Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research and development in this area focuses on enabling technologies, models, and methodologies to support basic and applied cancer research.

  12. Standard format and content of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    This document discusses the information that should be provided in the Safety Analysis Report and establishes a uniform format for presenting the information necessary to fulfill the licensing requirements for land disposal of radioactive waste called for in 10 CFR 61. The uniform format will (1) help ensure that the Safety Analysis Report contains the information required by 10 CFR 61, (2) aid the applicant and NRC staff in ensuring that the information is complete, (3) help persons reading the Safety Analysis Report to locate information, and (4) contribute to shortening the time needed for the review process

  13. Synthetic Biology: Applications in the Food Sector.

    Science.gov (United States)

    Tyagi, Ashish; Kumar, Ashwani; Aparna, S V; Mallappa, Rashmi H; Grover, Sunita; Batish, Virender Kumar

    2016-08-17

    Synthetic biology also termed as "genomic alchemy" represents a powerful area of science that is based on the convergence of biological sciences with systems engineering. It has been fittingly described as "moving from reading the genetic code to writing it" as it focuses on building, modeling, designing and fabricating novel biological systems using customized gene components that result in artificially created genetic circuitry. The scientifically compelling idea of the technological manipulation of life has been advocated since long time. Realization of this idea has gained momentum with development of high speed automation and the falling cost of gene sequencing and synthesis following the completion of the human genome project. Synthetic biology will certainly be instrumental in shaping the development of varying areas ranging from biomedicine, biopharmaceuticals, chemical production, food and dairy quality monitoring, packaging, and storage of food and dairy products, bioremediation and bioenergy production, etc. However, potential dangers of using synthetic life forms have to be acknowledged and adoption of policies by the scientific community to ensure safe practice while making important advancements in the ever expanding field of synthetic biology is to be fully supported and implemented.

  14. Synthetic Biology: Applications in the Food Sector.

    Science.gov (United States)

    Tyagi, Ashish; Kumar, Ashwani; Aparna, S V; Mallappa, Rashmi H; Grover, Sunita; Batish, Virender Kumar

    2016-08-17

    Synthetic biology also termed as "genomic alchemy" represents a powerful area of science that is based on the convergence of biological sciences with systems engineering. It has been fittingly described as "moving from reading the genetic code to writing it" as it focuses on building, modeling, designing and fabricating novel biological systems using customized gene components that result in artificially created genetic circuitry. The scientifically compelling idea of the technological manipulation of life has been advocated since long time. Realization of this idea has gained momentum with development of high speed automation and the falling cost of gene sequencing and synthesis following the completion of the human genome project. Synthetic biology will certainly be instrumental in shaping the development of varying areas ranging from biomedicine, biopharmaceuticals, chemical production, food and dairy quality monitoring, packaging, and storage of food and dairy products, bioremediation and bioenergy production, etc. However, potential dangers of using synthetic life forms have to be acknowledged and adoption of policies by the scientific community to ensure safe practice while making important advancements in the ever expanding field of synthetic biology is to be fully supported and implemented. PMID:25365334

  15. Exploiting for medical and biological applications

    Science.gov (United States)

    Giano, Michael C.

    Biotherapeutics are an emerging class of drug composed of molecules ranging in sizes from peptides to large proteins. Due to their poor stability and mucosal membrane permeability, biotherapeutics are administered by a parenteral method (i.e., syringe, intravenous or intramuscular). Therapeutics delivered systemically often experience short half-lives. While, local administration may involve invasive surgical procedures and suffer from poor retention at the site of application. To compensate, the patient receives frequent doses of highly concentrated therapeutic. Unfortunately, the off-target side effects and discomfort associated with multiple injections results in poor patient compliance. Therefore, new delivery methods which can improve therapeutic retention, reduce the frequency of administration and may aid in decreasing the off-target side effects is a necessity. Hydrogels are a class of biomaterials that are gaining interests for tissue engineering and drug delivery applications. Hydrogel materials are defined as porous, 3-dimensional networks that are primarily composed of water. Generally, they are mechanically rigid, cytocompatible and easily chemically functionalized. Collectively, these properties make hydrogels fantastic candidates to perform as drug delivery depots. Current hydrogel delivery systems physically entrap the target therapeutic which is then subsequently released over time at the site of administration. The swelling and degradation of the material effect the diffusion of the therapy from the hydrogel, and therefore should be controlled. Although these strategies provide some regulation over therapeutic release, full control of the delivery is not achieved. Newer approaches are focused on designing hydrogels that exploit known interactions, covalently attach the therapy or respond to an external stimulus in an effort to gain improved control over the therapy's release. Unfortunately, the biotherapeutic is typically required to be chemically

  16. The pre-licensing of a multi-purpose hybrid research reactor for high-tech applications 'MYRRHA'

    International Nuclear Information System (INIS)

    The Belgian Nuclear Research Centre in Mol has been working for several years on the design of a multi-purpose flexible irradiation facility in order to replace the ageing BR2, a multipurpose materials testing reactor (MTR), in operation since 1962. MYRRHA, a flexible fast spectrum research reactor is conceived as an accelerator driven system (ADS), able to operate in sub-critical and critical modes. It contains a proton accelerator of 600 MeV, a spallation target and a multiplying medium with MOX fuel, cooled by liquid lead-bismuth (Pb-Bi). Since February 2011, the Belgian Nuclear Research Centre has engaged in a 'pre-licensing' process with the regulatory authority for an estimated period up to mid 2014. The paper presents on the one hand the objectives of the pre-licensing phase as well as its implementation process and on the other hand, 2 implementing instruments which have been developed by the regulatory authority providing guidance to the designer of MYRRHA in order to meet the pre-licensing phase objectives. The first instrument is a strategic note for the design and operation of MYRRHA where as the second instrument is a guidance document for the format and content of a design options and provisions file (DOPF). Both instruments have been developed taking into account that MYRRHA is an irradiation facility using a Generation IV nuclear power system's type technology (liquid metal cooled fast neutron reactor). The strategic note overview aims to cover the safety approach as well as the security requirements and safeguards obligation applicable to MYRRHA. In particular, in the strategic note, a specific attention has been paid in order to ensure that a safety, security and safeguards integrated approach will drive the development of the MYRRHA design. The safety approach focuses on the safety goals and the minimum safety objectives set by the regulatory authority for this innovative design. The DOPF overview presents its objectives and structure resuming

  17. Hidden Markov processes theory and applications to biology

    CERN Document Server

    Vidyasagar, M

    2014-01-01

    This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. The book starts from first principles, so that no previous knowledge of probability is necessary. However, the work is rigorous and mathematical, making it useful to engineers and mathematicians, even those not interested in biological applications. A range of exercises is provided, including drills to familiarize the reader with concepts and more advanced problems that require deep thinking about the theory. Biological applications are t

  18. Application of computational intelligence to biology

    CERN Document Server

    Sekhar, Akula

    2016-01-01

    This book is a contribution of translational and allied research to the proceedings of the International Conference on Computational Intelligence and Soft Computing. It explains how various computational intelligence techniques can be applied to investigate various biological problems. It is a good read for Research Scholars, Engineers, Medical Doctors and Bioinformatics researchers.

  19. Marine Carotenoids: Biological Functions and Commercial Applications

    NARCIS (Netherlands)

    Vilchez, C.; Forján, E.; Cuaresma, M.; Bédmar, F.; Garbayo, I.; Vega, J.M.

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functi

  20. Recent Applications of Hidden Markov Models in Computational Biology

    Institute of Scientific and Technical Information of China (English)

    Khar Heng Choo; Joo Chuan Tong; Louxin Zhang

    2004-01-01

    This paper examines recent developments and applications of Hidden Markov Models (HMMs) to various problems in computational biology, including multiple sequence alignment, homology detection, protein sequences classification, and genomic annotation.

  1. Some Experiments with Biological Applications for the Elementary Laboratory

    Science.gov (United States)

    Kammer, D. W.; Williams, J. A.

    1975-01-01

    Summarizes physics laboratory experiments with applications in the biological sciences. Includes the following topics: mechanics of the human arm, fluid flow in tubes, physics of learning, the electrocardiograph, nerve impulse conduction, and corrective lenses for eye defects. (Author/MLH)

  2. Stochastic chemical kinetics theory and (mostly) systems biological applications

    CERN Document Server

    Érdi, Péter

    2014-01-01

    This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.

  3. Application of vibrational microspectroscopy to biology and medicine

    OpenAIRE

    Singh, Bhawana; Gautam, Rekha; Kumar, Srividya; Kumar, Vinay BN; Nongthomba, Upendra; Nandi, Dipankar; Mukherjee, Geetashree; Santosh, Vani; Somasundaram, Kumaravel; Umapathy, Siva

    2012-01-01

    Vibrational microspectroscopic (Raman and infrared (IR)) techniques are rapidly emerging as effective tools to probe the basic processes of life. This review mainly focuses on the applications of Raman and IR microspectroscopy to biology and biomedicine, ranging from studies on cellular components in single cells to advancement in techniques for in vitro to in vivo applications. These techniques have proved to be instrumental in studying the biological specimen with minimum perturbation, i.e....

  4. Contestable Licensing

    OpenAIRE

    Zvika Neeman; Orosel, Gerhard O.

    2000-01-01

    We analyze a model of repeated franchise bidding for natural monopoly with contestable licensing - a franchisee halds an (exclusive) license to operate a franchise until another rm offers to pay more for it. In a world where quality is observable but not veri able, the simple regulatory scheme we describe combines market-like incentives with regulatory oversight to generate efficient outcomes.

  5. Grafting of Porous Polymers for Biological Applications

    International Nuclear Information System (INIS)

    Research on application of radiation processing to polymers is mainly focused by the National Atomic Commission (CNEA). The Agricultural and Industrial Applications Laboratory Unit operates at the Ezeiza Atomic Center since the end of 1980s. Since 1997 a new research group headed by Dr. O. Cascone and Dr. M. Grasselli, devoted to downstream processing of proteins from the University of Buenos Aires, was involved in the implementation of grafting techniques in collaboration with Dr. E. Smolko from CNEA. In 1999 Dr. M. Grasselli moved to the Universidad Nacional de Quilmes where he continued working on application of gamma radiation to materials for biotechnological process. (author)

  6. How synthetic biology will reconsider natural bioluminescence and its applications.

    Science.gov (United States)

    Reeve, Benjamin; Sanderson, Theo; Ellis, Tom; Freemont, Paul

    2014-01-01

    As our understanding of natural biological systems grows, so too does our ability to alter and rebuild them. Synthetic biology is the application of engineering principles to biology in order to design and construct novel biological systems for specific applications. Bioluminescent organisms offer a treasure trove of light-emitting enzymes that may have applications in many areas of bioengineering, from biosensors to lighting. A few select bioluminescent organisms have been well researched and the molecular and genetic basis of their luminescent abilities elucidated, with work underway to understand the basis of luminescence in many others. Synthetic biology will aim to package these light-emitting systems as self-contained biological modules, characterize their properties, and then optimize them for use in other chassis organisms. As this catalog of biological parts grows, synthetic biologists will be able to engineer complex biological systems with the ability to emit light. These may use luminescence for an array of disparate functions, from providing illumination to conveying information or allowing communication between organisms. PMID:25216951

  7. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  8. Nanopatterning and nanoscale devices for biological applications

    CERN Document Server

    Šelimović, Seila

    2014-01-01

    ""This book is a good reference for researchers interested in realizing bio-applications based on micro- and nanostructures, where their interface with liquids and biomolecules is the key point. The most important 'players' of micro- and nano-bioengineering are considered, from DNA to proteins and cells. The work is a good merger of basic concepts and real examples of applications.""-Danilo Demarchi, Politecnico di Torino, Italy

  9. Physics and applications of microfluidics in biology.

    Science.gov (United States)

    Beebe, David J; Mensing, Glennys A; Walker, Glenn M

    2002-01-01

    Fluid flow at the microscale exhibits unique phenomena that can be leveraged to fabricate devices and components capable of performing functions useful for biological studies. The physics of importance to microfluidics are reviewed. Common methods of fabricating microfluidic devices and systems are described. Components, including valves, mixers, and pumps, capable of controlling fluid flow by utilizing the physics of the microscale are presented. Techniques for sensing flow characteristics are described and examples of devices and systems that perform bioanalysis are presented. The focus of this review is microscale phenomena and the use of the physics of the scale to create devices and systems that provide functionality useful to the life sciences.

  10. The application of ESEM to biological samples

    Energy Technology Data Exchange (ETDEWEB)

    McGregor, J E; Donald, A M, E-mail: jem60@cam.ac.u [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 OHE (United Kingdom)

    2010-07-01

    The Environmental Scanning Electron Microscope (ESEM) differs from a conventional SEM in that a differential pumping system maintains a pressure of gas (typically H{sub 2}O) in the specimen chamber whilst the gun remains at high vacuum. Ionizing collisions between electrons and these gas molecules create positive ions which drift down onto the sample neutralising specimen charge. It is therefore possible to image insulating samples without the need for metallic coating. The presence of water vapour in the chamber also means that a high relative humidity can be maintained and samples can be imaged in a hydrated state without the need for dehydration and fixation. These features suggest that ESEM could be well suited to imaging biological samples undergoing natural biological processes. We present a proof of principle study on the closure of stomatal pores in Tradescantia andersonia leaf tissue. An imaging protocol is developed and the advantages and limitations of this technique are discussed. Images of Vicia fabaleaf tissue are also presented. Challenges include minimising beam damage and reconciling the need for an adequate physiological temperature and a low gas pressure favourable for imaging, with the thermodynamic constraints on achieving a high relative humidity.

  11. 关联数据开放应用协议%The Open Application Licenses of Linked Data

    Institute of Scientific and Technical Information of China (English)

    张春景; 刘炜; 夏翠娟; 赵亮

    2012-01-01

    For the past few years Linked Data has been increasingly used in business, media, publication and governmental areas. In the process of publishing, consuming and re-creation of Linked Data, issues as to the ownership, the rights to use and publish, and who can benefit from Linked Data need to be appropriately addressed. Currently, the main agreements are Creative Commons family including CC BY-SA, CCO, CC BY, and CC BY-NC; the Open Data Commons family including Public Domain Dedication and License, Open Data License, Open Data Commons Attribution License and Open Government License and so on. Some suggestions on the application of Linked Data in China are put forward. 1 tab. 15 refs.%关联数据的应用正迅速发展并涉及到商业、媒体、出版、政府等领域。在关联数据发布、消费和再创造的过程中,必然涉及参与者的利益问题,需明确不同类型和归属的数据(或数据集)的所有权、发布权、使用权、收益权等。关联数据的发展迫切需要相关的许可协议。目前关联数据用到的协议主要有CC(知识共享)家族的CCBY-SA、CC0、CCBY、CCBY.NC和ODC(开放数据共用组织)的PDDL(公共领域奉献和许可),ODbL(开放数据许可)、ODC—By(开放数据共享署名许可),以及OGL(Open Government License,开放政府许可协议)等。对开放数据相关许可协议在国内的应用提出建议。表1。参考文献15。

  12. Licensing experiences of safety critical software systems in nuclear applications a case study

    International Nuclear Information System (INIS)

    This paper summarizes results of reviews on the safety, critical software performed during the licensing process for the new Wolsung units. Each of these CANDU-type nuclear power plants has two micro-computerized shutdown systems. The SDS No. 1 program is graphically programmed in such a manner that its development process does not essentially differ from the design process of the conventional analog counterpart. This approach is understandable even to a reviewer in the regulatory agency without additional training in software engineering. The confidence in the reliability of this system is strengthened by the reverse verification and increased by extensive testing such as the reliability test. Concerning SDS No. 2, the development process is significantly influenced by the software cost reduction project of the U.S. naval research laboratory, and is, as a whole, clear and well structured except for the modules related to the operation of the computer itself. These modules contain some algorithms which are not easy to understand. However, their correctness verifications are requested by the reviewer and supplemented by the developer. After the clarification of these issues, there are no substantial problems that constitute a significant impediment to licensing. 32 refs., 7 figs

  13. 9 CFR 166.10 - Licensing.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Licensing. 166.10 Section 166.10... HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... regulations. (1) Prior to licensing, each applicant shall demonstrate during an inspection of the...

  14. Preparing as an organization, to submit or to review a construction license application for a DGR of ILW and HLW in France. French National Case - Andra - Preparing to Submit Cigeo's Creation License Application

    International Nuclear Information System (INIS)

    The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste. Since the first French Act on nuclear waste management research (1991), Andra has carried out twenty years of conceptual and basic studies on the subject, leading in particular to the feasibility demonstration in 2005 and to the choice of the detailed reconnaissance zone (ZIRA) in 2010. Taking advantage from this work, Andra has now reached a new phase where the project is engaging in the design of the industrial installation named Cigeo. At this stage, the further development of the project implies that Andra undertakes a multiplicity of actions in order to successfully reach various external and internal key milestones. Of paramount importance is the careful articulation between the regulatory authorization and decision processes and the outcome of the industrial installation design phases. In 2006 was built a regulatory framework that plans a succession of step by step decisions stages: 2013: Public debate on reversibility, memory keeping, environmental and health survey modalities, dialogue with the local stakeholders to harmoniously define and plan the external infrastructures that have to be developed to support the construction and the operation of Cigeo (roads, railway tracks and terminal, power and water supplies, etc.). 2015: Creation license application and start of the regulatory review process (notably various plans of the installation, the description of the solution envisaged for the closure of the facility, the preliminary safety case (operational safety, long-term safety, protection against malevolent actions, management of incidental situations, preliminary acceptance criteria), environmental impact studies (health, salubrity, transports, human activities, nature, patrimonial aspects). 2016-2017: new parliamentary Act on the reversibility conditions of the

  15. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  16. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  17. Auxin Biology: Applications and the Mechanisms Behind

    OpenAIRE

    Skůpa, P. (Petr); Opatrný, Z.; Petrášek, J. (Jan)

    2014-01-01

    This chapter describes the state of the contemporary knowledge of auxin action reflected in its applications in agriculture and biotechnology. We summarise the current understanding of the mechanism of action for endogenous and major synthetic auxins highlighting their morphogenic character that modulates numerous aspects of plant development. Various auxins and auxin-like compounds are used in techniques of plant vegetative propagation, in vitro culture and regeneration, and they play also a...

  18. 21 CFR 601.2 - Applications for biologics licenses; procedures for filing.

    Science.gov (United States)

    2010-04-01

    ... methods; data establishing stability of the product through the dating period; sample(s) representative of... section: (1) Therapeutic DNA plasmid products; (2) Therapeutic synthetic peptide products of 40 or fewer... which is a therapeutic DNA plasmid product, therapeutic synthetic peptide product of 40 or fewer...

  19. Directed evolution and synthetic biology applications to microbial systems.

    Science.gov (United States)

    Bassalo, Marcelo C; Liu, Rongming; Gill, Ryan T

    2016-06-01

    Biotechnology applications require engineering complex multi-genic traits. The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them. However, complex phenotypes can be engineered at the systems level, utilizing directed evolution strategies that drive whole biological systems toward desired phenotypes without requiring prior knowledge of the genetic basis of the targeted trait. Recent developments in the synthetic biology field accelerates the directed evolution cycle, facilitating engineering of increasingly complex traits in biological systems. In this review, we summarize some of the most recent advances in directed evolution and synthetic biology that allows engineering of complex traits in microbial systems. Then, we discuss applications that can be achieved through engineering at the systems level. PMID:27054950

  20. Biology and applications of mycorrhizal fungi.

    Science.gov (United States)

    Sharma, S; Madan, M; Vasudevan, P

    1997-12-01

    Mycorrhizae have been shown to increase growth and yield of plants. They have been identified with both nutrient mobilization and nutrient cycling. Arbuscular (or endo-) mycorrhizae play a significant role in agriculture and most natural ecosystems, whereas ectomycorrhizae have a great potential in forestry and wasteland regeneration. The use of mycorrhizal fungi would reduce dependence on chemical fertilizers besides minimizing environmental pollution. The present review addresses the progress that there has been in the area of the ecto- and endomycorrhizae. It also examines the potential of field applications of mycorrhizal biotechnology in agriculture and forestry.

  1. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  2. Issues in the review of a license application for an above grade low-level radioactive waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Ringenberg, J.D. [Nebraska Dept. of Environmental Quality, NE (United States)

    1993-03-01

    In December 1987, Nebraska was selected by the Central Interstate Compact (CIC) Commission as the host state for the construction of a low-level radioactive waste disposal facility. After spending a year in the site screening process, the Compact`s developer, US Ecology, selected three sites for detailed site characterization. These sites were located in Nemaha, Nuckolls and Boyd Counties. One year later the Boyd County site was selected as the preferred site and additional site characterization studies were undertaken. On July 29, 1990, US Ecology submitted a license application to the Nebraska Department of Environmental Control (now Department of Environmental Quality-NDEQ). This paper will present issues that the NDEQ has dealt with since Nebraska`s selection as the host state for the CIC facility.

  3. [Biological characteristics of calliphoridae and its application in forensic medicine].

    Science.gov (United States)

    Zhao, Boa; Wen, Charn; Qi, Li-Li; Wang, He; Wang, Ji

    2013-12-01

    Diptera Calliphoridae is the first major kind of flies that appears on the decomposed corpses. In forensic entomology, according to the living characteristics of Calliphoridae flies, we could accurately estimate postmortem interval (PMI) in a murder or unidentified case and could provide useful clues to solve the case. This paper introduces the characteristics of the biology and morphology of Diptera Calliphoridae, and reviews the combined application of forensic entomology, molecular biology, mathematical morphology and toxicology.

  4. 21 CFR 601.5 - Revocation of license.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Revocation of license. 601.5 Section 601.5 Food... LICENSING General Provisions § 601.5 Revocation of license. (a) A biologics license shall be revoked upon... for, and offering an opportunity for a hearing on the proposed revocation if the Commissioner...

  5. Graphene nanonet for biological sensing applications.

    Science.gov (United States)

    Kim, Taekyeong; Park, Jaesung; Jin, Hye Jun; Lee, Hyungwoo; Byun, Kyung-Eun; Lee, Chang-Seuk; Kim, Kwang S; Hong, Byung Hee; Kim, Tae Hyun; Hong, Seunghun

    2013-09-20

    We report a simple but efficient method to fabricate versatile graphene nanonet (GNN)-devices. In this method, networks of V2O5 nanowires (NWs) were prepared in specific regions of single-layer graphene, and the graphene layer was selectively etched via a reactive ion etching method using the V2O5 NWs as a shadow mask. The process allowed us to prepare large scale patterns of GNN structures which were comprised of continuous networks of graphene nanoribbons (GNRs) with chemical functional groups on their edges. The GNN can be easily functionalized with biomolecules for fluorescent biochip applications. Furthermore, electrical channels based on GNN exhibited a rather high mobility and low noise compared with other network structures based on nanostructures such as carbon nanotubes, which was attributed to the continuous connection of nanoribbons in GNN structures. As a proof of concept, we built DNA sensors based on GNN channels and demonstrated the selective detection of DNA. Since our method allows us to prepare high-performance networks of GNRs over a large surface area, it should open up various practical biosensing applications.

  6. Dealing with the current permissibility application for constructing a spent fuel DGR in Sweden. SKB's license applications for a spent fuel repository

    International Nuclear Information System (INIS)

    The nuclear power utilities in Sweden were in 1976 obliged to demonstrate a safe method for final disposal of spent fuel in order to start operation of new reactors. This initiated a comprehensive research, development and demonstration programme and the development of the KBS-method for final disposal. A new Nuclear Activities Act in 1984 gave the reactor owners full technical and financial responsibility for the waste. They gave in turn SKB the responsibility for all nuclear waste management. Reprocessing was no longer required and direct disposal of the spent fuel has, since then, been the main alternative. Alternative methods for final disposal have been evaluated and compared to the KBS-3-method but it has remained the preferred alternative. A comprehensive research, development and demonstration programme to strengthen the scientific basis and to refine the KBS-3-method has been operated by SKB since then. The site selection process for the final repository for spent nuclear fuel was initiated in 1992. The work included general siting studies at the national and the municipal level and in 2002, SKB initiated site investigations for siting of a final repository on two sites: the Simpevarp and Laxemar areas and the Forsmark area. At the same time, the work on preparing license applications to construct and operate an encapsulation plant and a final repository for spent fuel was started. In June 2009, SKB announced Forsmark as the selected site for the final repository. This paper reviews the applicable legislation and describes the license application, the licensing review and the preparations for implementation

  7. Recent applications of synthetic biology tools for yeast metabolic engineering

    DEFF Research Database (Denmark)

    Jensen, Michael Krogh; Keasling, Jay

    2015-01-01

    engineer microbial chemical factories has steadily decreased, improvement is still needed. Through the development of synthetic biology tools for key microbial hosts, it should be possible to further decrease the development times and improve the reliability of the resulting microorganism. Together with...... continuous decreases in price and improvements in DNA synthesis, assembly and sequencing, synthetic biology tools will rationalize time-consuming strain engineering, improve control of metabolic fluxes, and diversify screening assays for cellular metabolism. This review outlines some recently developed...... synthetic biology tools and their application to improve production of chemicals and fuels in yeast. Finally, we provide a perspective for the challenges that lie ahead....

  8. Structural biology applications of solid state MAS DNP NMR

    Science.gov (United States)

    Akbey, Ümit; Oschkinat, Hartmut

    2016-08-01

    Dynamic Nuclear Polarization (DNP) has long been an aim for increasing sensitivity of nuclear magnetic resonance (NMR) spectroscopy, delivering spectra in shorter experiment times or of smaller sample amounts. In recent years, it has been applied in magic angle spinning (MAS) solid-state NMR to a large range of samples, including biological macromolecules and functional materials. New research directions in structural biology can be envisaged by DNP, facilitating investigations on very large complexes or very heterogeneous samples. Here we present a summary of state of the art DNP MAS NMR spectroscopy and its applications to structural biology, discussing the technical challenges and factors affecting DNP performance.

  9. Applications of dynamical systems in biology and medicine

    CERN Document Server

    Radunskaya, Ami

    2015-01-01

    This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control.  Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction.  Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation. .

  10. Biologically active extracts with kidney affections applications

    Science.gov (United States)

    Pascu (Neagu), Mihaela; Pascu, Daniela-Elena; Cozea, Andreea; Bunaciu, Andrei A.; Miron, Alexandra Raluca; Nechifor, Cristina Aurelia

    2015-12-01

    This paper is aimed to select plant materials rich in bioflavonoid compounds, made from herbs known for their application performances in the prevention and therapy of renal diseases, namely kidney stones and urinary infections (renal lithiasis, nephritis, urethritis, cystitis, etc.). This paper presents a comparative study of the medicinal plant extracts composition belonging to Ericaceae-Cranberry (fruit and leaves) - Vaccinium vitis-idaea L. and Bilberry (fruit) - Vaccinium myrtillus L. Concentrated extracts obtained from medicinal plants used in this work were analyzed from structural, morphological and compositional points of view using different techniques: chromatographic methods (HPLC), scanning electronic microscopy, infrared, and UV spectrophotometry, also by using kinetic model. Liquid chromatography was able to identify the specific compounds of the Ericaceae family, present in all three extracts, arbutosid, as well as specific components of each species, mostly from the class of polyphenols. The identification and quantitative determination of the active ingredients from these extracts can give information related to their therapeutic effects.

  11. Biological Applications of Extraordinary Electroconductance (EEC)

    Science.gov (United States)

    Tran, L. C.; Werner, F. M.; Solin, S. A.

    2014-03-01

    Rapid detection of biomolecular concentration is a fundamental goal for lab on a chip diagnostic systems. The Extraordinary Electroconductance (EEC) sensor, a stacked, AuTi-GaAs metal semiconductor hybrid structure (MSH), has been previously demonstrated to have an electric field sensitivity of 3.05V/cm in a mesoscopic-scale structure fabricated at the center of a parallel plate capacitor. In this work, we demonstrate the first successful application of EEC sensors as electrochemical detectors of molecular binding to the sensor surface. The negatively charged avidin derivative, captavidin, was applied with varying captavidin concentrations in phosphate buffered saline (PBS). The four-point measured resistance of bare EEC sensors was shown to increase by a factor of four due to captavidin binding at the sensor surface, as compared to a baseline binding assay in which the captavidin binding sites were blocked. Calculations for approximate electric field strengths introduced by a bound captavidin molecule will also presented. EEC sensors' four point measurements showed robustness and stability in spite of variations in the functional, linking layer. S.A.S. is a co-founder of and has a financial interest in PixelEXX, a start-up company whose mission is to market imaging arrays.

  12. 9 CFR 102.2 - Licenses required.

    Science.gov (United States)

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL PRODUCTS § 102.2 Licenses required. (a) Every person who prepares biological products subject to the Virus-Serum-Toxin...

  13. Application of PLUTO Test Facility for U. S. NRC Licensing of a Fuel Assembly

    International Nuclear Information System (INIS)

    The fuel assembly of the PLUS-7 loaded in the APR-1400 follows the same schedule. Meanwhile, In July 1998, the U.S. NRC adopted a research plan to address the effects of high burnup from a Loss of Coolant Accident (LOCA). From these programs, several important technical findings for rule revision were obtained. Based on the technical findings, the U. S. NRC has amended the 10 CFR 50.46 which will be proclaimed sooner or later. Through the amendment, a LOCA analysis on the fuel assembly has to show the safety at both a fresh and End of Life (EOL) state. The U. S. NRC has already required EOL effects on seismic/LOCA performance for a fuel assembly since 1998. To obtain U.S NRC licensing of a fuel assembly, based on the amendment of 10CFR50.46, a LOCA analysis of the fuel assembly has to show safety both fresh and EOL states. The proper damping factor of the fuel assembly measured at the hydraulic test loop for a dynamic model in a LOCA and a seismic analysis code are at least required. In this paper, we have examined the damping technologies and compared the test facility of PLUTO with others in terms of performance. PLUTO has a better performance on the operating conditions than any others

  14. Application of PLUTO Test Facility for U. S. NRC Licensing of a Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dongseok; Shin, Changhwan; Lee, Kanghee; Kang, Heungseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    The fuel assembly of the PLUS-7 loaded in the APR-1400 follows the same schedule. Meanwhile, In July 1998, the U.S. NRC adopted a research plan to address the effects of high burnup from a Loss of Coolant Accident (LOCA). From these programs, several important technical findings for rule revision were obtained. Based on the technical findings, the U. S. NRC has amended the 10 CFR 50.46 which will be proclaimed sooner or later. Through the amendment, a LOCA analysis on the fuel assembly has to show the safety at both a fresh and End of Life (EOL) state. The U. S. NRC has already required EOL effects on seismic/LOCA performance for a fuel assembly since 1998. To obtain U.S NRC licensing of a fuel assembly, based on the amendment of 10CFR50.46, a LOCA analysis of the fuel assembly has to show safety both fresh and EOL states. The proper damping factor of the fuel assembly measured at the hydraulic test loop for a dynamic model in a LOCA and a seismic analysis code are at least required. In this paper, we have examined the damping technologies and compared the test facility of PLUTO with others in terms of performance. PLUTO has a better performance on the operating conditions than any others.

  15. Application of the best-estimate approach for the licensing process of NPPS with RBMK reactors

    International Nuclear Information System (INIS)

    According to the international practice, the best-estimate approach is used mainly for Loss of Coolant Accident (LOCA) in reactor cooling circuit type accidents. In Lithuania the best estimate approach was successfully applied not only for LOCA, but also for accident confinement system response and processes in fuel rods analyses. This paper presents the following three examples of best-estimate accident analysis, developed for the licensing of Ignalina NPP with RBMK-1500 reactors: Large LOCA case in main circulation circuit; Processes in reactor cavity after rupture of fuel channels; Change of fuel rod parameters during operation. Thermal hydraulic analyses were performed by employing best estimate thermal-hydraulic codes RELAP5 Mod3.2 (for the analysis of reactor cooling circuit response) and CONTAIN (for the analysis of reactor cavity response). In order to evaluate the uncertainties of calculation, the GRS methodology and computer code of statistical methods SUSA 3.5 was employed. The main findings may be applied for the RBMK-1000 reactors, operating in Russia, and for other light water reactors. (author)

  16. Biological applications of confocal fluorescence polarization microscopy

    Science.gov (United States)

    Bigelow, Chad E.

    Fluorescence polarization microscopy is a powerful modality capable of sensing changes in the physical properties and local environment of fluorophores. In this thesis we present new applications for the technique in cancer diagnosis and treatment and explore the limits of the modality in scattering media. We describe modifications to our custom-built confocal fluorescence microscope that enable dual-color imaging, optical fiber-based confocal spectroscopy and fluorescence polarization imaging. Experiments are presented that indicate the performance of the instrument for all three modalities. The limits of confocal fluorescence polarization imaging in scattering media are explored and the microscope parameters necessary for accurate polarization images in this regime are determined. A Monte Carlo routine is developed to model the effect of scattering on images. Included in it are routines to track the polarization state of light using the Mueller-Stokes formalism and a model for fluorescence generation that includes sampling the excitation light polarization ellipse, Brownian motion of excited-state fluorophores in solution, and dipole fluorophore emission. Results from this model are compared to experiments performed on a fluorophore-embedded polymer rod in a turbid medium consisting of polystyrene microspheres in aqueous suspension. We demonstrate the utility of the fluorescence polarization imaging technique for removal of contaminating autofluorescence and for imaging photodynamic therapy drugs in cell monolayers. Images of cells expressing green fluorescent protein are extracted from contaminating fluorescein emission. The distribution of meta-tetrahydroxypheny1chlorin in an EMT6 cell monolayer is also presented. A new technique for imaging enzyme activity is presented that is based on observing changes in the anisotropy of fluorescently-labeled substrates. Proof-of-principle studies are performed in a model system consisting of fluorescently labeled bovine

  17. Analysis Method for Licensing Application of Passive Autocatalytic Recombiner System as a Hydrogen Mitigation System of OPR-1000

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Changhyun; Sung, Jejoong; Ha, Sangjun [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of); Yeo, Inseon [KEPCO Engineering and Construction Co. Ltd., Yongin (Korea, Republic of)

    2014-05-15

    As a result, for some plants, dual hydrogen mitigation systems are prepared with a combination of PARs and igniters that each system has a 100% of full capacity for hydrogen control for postulated severe accident conditions. In the original design of OPR-1000, hydrogen mitigation systems consist of a thermal recombiner and twenty glow-type igniters, which are used for design basis accident and severe accident, respectively. This paper presents an analysis method for licensing application in Korea to determine the capacity and locations of PARs for the design of a hydrogen mitigation system with PAR. A licensed analysis method of OPR-1000 has been presented to determine the capacity and locations of PAR for the design of a hydrogen mitigation system with PAR. A lumped parameter code of MAAP 4.0.6+ has been adopted to simulate various severe accident scenarios with a 26 multi-compartment containment model. Hydrogen generations were analysed and required capacity and locations of PAR were determined for six accident scenarios selected from a combination of probabilistic and deterministic considerations. A total of twenty-four PARs in the containment dome, steam generator rooms, annulus and adjacent areas was designed and the adequacy of this system has been confirmed through detailed analyses including sensitivity analyses with/without operations of safety systems such as containment heat removal systems, reactor coolant depressurization system and safety injection by accumulator, etc. Through the assessment on the possibility of global FA and DDT, it has been concluded that new PAR system with twenty-four recombiners can remove hydrogen effectively in the containment atmosphere and prevent from global FA and DDT. Further works are required in the future to develop a well-balanced analysis methodology with a combination of lumped and CFD tools focusing on the optimum locations of recombiners and local hydrogen behaviour in containment compartments.

  18. 78 FR 79503 - Tennessee Valley Authority, Combined License Application for Bellefonte Units 3 and 4 Exemption...

    Science.gov (United States)

    2013-12-30

    ... (COL) application until further notice. On October 28, 2013, TVA requested an exemption from certain...) until requesting the NRC to resume its review of their COL application. The NRC staff reviewed this... report must be submitted prior to requesting the NRC resume its review of the COL application or...

  19. 75 FR 4081 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

    Science.gov (United States)

    2010-01-26

    ... application for FDA review and approval before marketing a biological product in interstate commerce. Licenses... studies are not ethical or feasible. Section 601.91(b)(3) requires applicants to prepare and provide... part 601, subpart H when human efficacy studies are not ethical or feasible (or based on evidence...

  20. 10 CFR 110.43 - Import licensing criteria.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Import licensing criteria. 110.43 Section 110.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Review of License Applications § 110.43 Import licensing criteria. The review of license applications for...

  1. Flow cytometric applications of tumor biology: prospects and pitfalls

    International Nuclear Information System (INIS)

    A brief review of cytometry instrumentation and its potential applications in tumor biology is presented using our recent data. Age-distribution measurements of cells from spontaneous dog tumors and cultured cells after exposure to x rays, alpha particles, or adriamycin are shown. The data show that DNA fluorescence measurements have application in the study of cell kinetics after either radiation or drug treatment. Extensive and careful experimentation is needed to utilize the sophisticated developments in flow cytometry instrumentation

  2. Application of Bioinformatics and Systems Biology in Medicinal Plant Studies

    Institute of Scientific and Technical Information of China (English)

    DENG You-ping; AI Jun-mei; XIAO Pei-gen

    2010-01-01

    One important purpose to investigate medicinal plants is to understand genes and enzymes that govern the biological metabolic process to produce bioactive compounds.Genome wide high throughput technologies such as genomics,transcriptomics,proteomics and metabolomics can help reach that goal.Such technologies can produce a vast amount of data which desperately need bioinformatics and systems biology to process,manage,distribute and understand these data.By dealing with the"omics"data,bioinformatics and systems biology can also help improve the quality of traditional medicinal materials,develop new approaches for the classification and authentication of medicinal plants,identify new active compounds,and cultivate medicinal plant species that tolerate harsh environmental conditions.In this review,the application of bioinformatics and systems biology in medicinal plants is briefly introduced.

  3. Novel computational biology methods and their applications to drug discovery

    Institute of Scientific and Technical Information of China (English)

    Sharangdhar S. PHATAK; Hoang T. TRAN; Shuxing ZHANG

    2011-01-01

    Computational biology methods are now firmly entrenched in the drug discovery process.These methods focus on modeling and simulations of biological systems to complement and direct conventional experimental approaches.Two important branches of computational biology include protein homology modeling and the computational biophysics method of molecular dynamics.Protein modeling methods attempt to accurately predict three-dimensional (3D) structures of uncrystallized proteins for subsequent structure-based drug design applications.Molecular dynamics methods aim to elucidate the molecular motions of the static representations of crystallized protein structures.In this review we highlight recent novel methodologies in the field of homology modeling and molecular dynamics.Selected drug discovery applications using these methods conclude the review.

  4. Differential Scanning Calorimetry Techniques: Applications in Biology and Nanoscience

    OpenAIRE

    Gill, Pooria; Moghadam, Tahereh Tohidi; Ranjbar, Bijan

    2010-01-01

    This paper reviews the best-known differential scanning calorimetries (DSCs), such as conventional DSC, microelectromechanical systems-DSC, infrared-heated DSC, modulated-temperature DSC, gas flow-modulated DSC, parallel-nano DSC, pressure perturbation calorimetry, self-reference DSC, and high-performance DSC. Also, we describe here the most extensive applications of DSC in biology and nanoscience.

  5. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  6. Integrated graphene/nanoparticle hybrids for biological and electronic applications

    Science.gov (United States)

    Nguyen, Kim Truc; Zhao, Yanli

    2014-05-01

    The development of novel graphene/nanoparticle hybrid materials is currently the subject of tremendous research interest. The intrinsic exceptional assets of both graphene (including graphene oxide and reduced graphene oxide) and nanoparticles render their hybrid materials synergic properties that can be useful in various applications. In this feature review, we highlight recent developments in graphene/nanoparticle hybrids and their promising potential in electronic and biological applications. First, the latest advances in synthetic methods for the preparation of the graphene/nanoparticle hybrids are introduced, with the emphasis on approaches to (1) decorate nanoparticles onto two-dimensional graphene and (2) wrap nanoparticles with graphene sheets. The pros and cons of large-scale synthesis are also discussed. Then, the state-of-the-art of graphene/nanoparticle hybrids in electronic and biological applications is reviewed. For electronic applications, we focus on the advantages of using these hybrids in transparent conducting films, as well as energy harvesting and storage. Biological applications, electrochemical biosensing, bioimaging, and drug delivery using the hybrids are showcased. Finally, the future research prospects and challenges in this rapidly developing area are discussed.

  7. Application of synthetic biology in cyanobacteria and algae

    Directory of Open Access Journals (Sweden)

    Bo eWang

    2012-09-01

    Full Text Available Cyanobacteria and algae are becoming increasingly attractive cell factories for producing renewable biofuels and chemicals due to their ability to capture solar energy and CO2 and their relatively simple genetic background for genetic manipulation. Increasing research efforts from the synthetic biology approach have been made in recent years to modify cyanobacteria and algae for various biotechnological applications. In the article, we critically review recent progresses in developing genetic tools for characterizing or manipulating cyanobacteria and algae, the applications of genetically modified strains for synthesizing renewable products such as biofuels and chemicals. In addition, the emergent challenges in the development and application of synthetic biology for cyanobacteria and algae are also discussed.

  8. Click Chemistry Mediated Functionalization of Vertical Nanowires for Biological Applications.

    Science.gov (United States)

    Vutti, Surendra; Schoffelen, Sanne; Bolinsson, Jessica; Buch-Månson, Nina; Bovet, Nicolas; Nygård, Jesper; Martinez, Karen L; Meldal, Morten

    2016-01-11

    Semiconductor nanowires (NWs) are gaining significant importance in various biological applications, such as biosensing and drug delivery. Efficient and controlled immobilization of biomolecules on the NW surface is crucial for many of these applications. Here, we present for the first time the use of the Cu(I) -catalyzed alkyne-azide cycloaddition and its strain-promoted variant for the covalent functionalization of vertical NWs with peptides and proteins. The potential of the approach was demonstrated in two complementary applications of measuring enzyme activity and protein binding, which is of general interest for biological studies. The attachment of a peptide substrate provided NW arrays for the detection of protease activity. In addition, green fluorescent protein was immobilized in a site-specific manner and recognized by antibody binding to demonstrate the proof-of-concept for the use of covalently modified NWs for diagnostic purposes using minute amounts of material.

  9. Photo-Triggered Click Chemistry for Biological Applications.

    Science.gov (United States)

    Herner, András; Lin, Qing

    2016-02-01

    In the last decade and a half, numerous bioorthogonal reactions have been developed with a goal to study biological processes in their native environment, i.e., in living cells and animals. Among them, the photo-triggered reactions offer several unique advantages including operational simplicity with the use of light rather than toxic metal catalysts and ligands, and exceptional spatiotemporal control through the application of an appropriate light source with pre-selected wavelength, light intensity and exposure time. While the photoinduced reactions have been studied extensively in materials research, e.g., on macromolecular surface, the adaptation of these reactions for chemical biology applications is still in its infancy. In this chapter, we review the recent efforts in the discovery and optimization the photo-triggered bioorthogonal reactions, with a focus on those that have shown broad utility in biological systems. We discuss in each cases the chemical and mechanistic background, the kinetics of the reactions and the biological applicability together with the limiting factors. PMID:27397964

  10. An introduction to stochastic processes with applications to biology

    CERN Document Server

    Allen, Linda J S

    2010-01-01

    An Introduction to Stochastic Processes with Applications to Biology, Second Edition presents the basic theory of stochastic processes necessary in understanding and applying stochastic methods to biological problems in areas such as population growth and extinction, drug kinetics, two-species competition and predation, the spread of epidemics, and the genetics of inbreeding. Because of their rich structure, the text focuses on discrete and continuous time Markov chains and continuous time and state Markov processes.New to the Second EditionA new chapter on stochastic differential equations th

  11. 47 CFR 13.9 - Eligibility and application for new license or endorsement.

    Science.gov (United States)

    2010-10-01

    ... by telephone spoken messages in English. (b)(1) Each application for a new General Radiotelephone... examination(s) within the previous 365 days, is authorized to exercise the rights and privileges of...

  12. Viability Assessment of a Repository at Yucca Mountain. Volume 4: License Application Plan and Costs

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-01

    defensible LA. Volume 4 is divided into seven sections. Section 2 presents a rationale and summary for the technical work to be done to develop the preclosure and postclosure safety cases that will support the compliance evaluations required for the evaluation of site suitability and for licensing. Section 2 also describes other necessary technical work, including that needed to support design decisions and development of the necessary design information. Section 3 presents a more detailed description of the technical work required to address the issues identified in Section 2. Section 3 also describes activities that will continue after submittal of the site recommendation and the LA. Examples include the drift scale heater test in the Exploratory Studies Facility (Section 3.1.4.3) and long-term waste package corrosion testing (Section 3.2.2.9). Section 4 discusses the statutory and regulatory framework for site recommendation and submittal of an LA, and describes the activities and documentation that must be completed to achieve these milestones, including the development of an EIS. Section 5 describes the numerous activities required to support program milestones, including support for completing the testing program, continuing tests as part of the performance confirmation program, and managing information and records to support regulatory and legal review. Sections 6 and 7 provide cost and schedule information for the activities planned.

  13. Biological isotopy. Introduction to the isotopic effects and to their applications in biology

    International Nuclear Information System (INIS)

    Since their discovery in the beginning of the 20. century, the study of stable isotopes has considerably developed. This domain, which remained limited in its applications until the 1990's, has become particularly important thereafter thanks to its practical applications and in particular to its economical impacts. Many techniques used in fraud control, in drugs use control, in selection of high-yield plants etc are based on isotopic abundance measurements. This reference book gives a synthesis of our actual knowledge on the use of stable isotopes and of isotope fractionation in biology. It presents the basic notions of isotopic biochemistry and explains the origin of the isotopic effects. The application principles of these effects to metabolism, to organisms physiology, to environmental biology etc are explained and detailed using examples and exercises. The first chapters present the basic knowledge which defines, from a mathematical point-of-view, the isotopic effects of chemical reactions or of physical processes taking place in biology. The measurements principle of natural isotopes abundance is then synthesised. Finally, all these notions are applied at different scales: enzymes, physiology, metabolism, environment, ecosystems and fraud crackdown. (J.S.)

  14. Compliance with applicable national environmental policy requirements for licensing a new nuclear power plant world-wide

    International Nuclear Information System (INIS)

    Assuring the protection of humans and their environment is of great concern to nuclear electric power generators and regulators, as we move towards a full scale nuclear renaissance. The applicable national environmental policies of the host country usually require government agencies and the permit applicants to consider environmental impacts in making decisions and to disclose these environmental impacts to the public. For licensing a new nuclear power plant, the applicant submits an Environmental Report (ER) or an equivalent report, Environmental Impact Assessment (EIA) to the local designated permitting agency for review. The ER/EIA provides the agency with a comprehensive description of the environmental baseline conditions, the probable impacts of the proposed project, and the potential mitigation and monitoring efforts. In general, the report supports the host country's goals of environmental protection and sustainable development; integrates environmental protection and economic decisions; predicts environmental, social, and economic consequences of the proposed activity and assesses plans to mitigate any adverse impacts resulting from the proposed activity; and provides for the involvement of government and other agencies in the review of the proposed activity. This paper covers issues concerning the evaluation of potential land use, water use, and ecological and socioeconomic impacts of a new nuclear power plant, as addressed in an ER/EIA. It specifically focuses on the evaluation and mitigation of potential cumulative impacts of new nuclear power plant construction and operation, and its alternative sites and plant systems. Case studies related to selection of plant systems based on local environmental site conditions, preferred compliance plan, and public acceptances are included. (author)

  15. [Development of Zn(2+) selective fluorescent probes for biological applications].

    Science.gov (United States)

    Hagimori, Masayori

    2013-01-01

    Zn(2+) is an essential element for life and is known to play important roles in biological processes including gene expression, apoptosis, enzyme regulation, immune system and neurotransmission. To investigate physiological roles of free or chelatable Zn(2+) in living cells, Zn(2+)-selective fluorescent probes are valuable tools. A variety of fluorescent probes based on quinoline, BF2 chelated dipyrromethene, fluorescein, etc. has been developed recently. In principle, such tools can provide useful information about zinc biology. However, most of the fluorescent probes presented so far possess a fluorescent core and a separate part for binding to Zn(2+) within the molecule, so that the molecular weight is usually large and the molecules are hydrophobic. As a result, the applications of such molecules in biological systems often face difficulties. Therefore, we need to develop a new class of fluorescent probes for Zn(2+) with improved molecular characteristics. If the initial core structure is small enough, the fluorescent probes may still be molecular weight below 500 with desirable physico-chemical properties, even after the modifications. In this review, we described novel low-molecular-weight fluorescent probes for Zn(2+) based on pyridine-pyridone. Small modification of pyridine-pyridone core structure brought about a marked improvement such as aqueous solubility, affinity toward Zn(2+), and fluorescence ON/OFF switching. Fluorescence images of Zn(2+) in cells showed that the pyridine-pyridone probe can be used in biological applications.

  16. Review of neutron radiographic applications in industrial and biological systems

    International Nuclear Information System (INIS)

    Neutron radiography is a non-destructive testing technique and is being used worldwide for the design and the development of reactor fuels for research and power reactors. It is also being used for non-destructive examination of nuclear industrial products. In addition to its explosives and other industrial sectors. In addition to its applications in industrial sectors, the technique is widely used for research and development activities in biological systems. A review of technical applications of neutron radiography in different fields particularly in nuclear fuel management, aerospace industry, explosives and biology is presented. The methodology of neutron radiography is also discussed in detail along with the advantages of the technique. In addition, the potential of the neutron radiography facility at PINSTECH has been described. (author)

  17. Research Applications of Proteolytic Enzymes in Molecular Biology

    Directory of Open Access Journals (Sweden)

    József Tőzsér

    2013-11-01

    Full Text Available Proteolytic enzymes (also termed peptidases, proteases and proteinases are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications require their use, including production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, cell culturing and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics and therapy, exploration of the structure-function relationships by structural studies, removal of affinity tags from fusion proteins in recombinant protein techniques, peptide sequencing and proteolytic digestion of proteins in proteomics. The aim of this paper is to review the molecular biological aspects of proteolytic enzymes and summarize their applications in the life sciences.

  18. Applications of large-scale density functional theory in biology.

    Science.gov (United States)

    Cole, Daniel J; Hine, Nicholas D M

    2016-10-01

    Density functional theory (DFT) has become a routine tool for the computation of electronic structure in the physics, materials and chemistry fields. Yet the application of traditional DFT to problems in the biological sciences is hindered, to a large extent, by the unfavourable scaling of the computational effort with system size. Here, we review some of the major software and functionality advances that enable insightful electronic structure calculations to be performed on systems comprising many thousands of atoms. We describe some of the early applications of large-scale DFT to the computation of the electronic properties and structure of biomolecules, as well as to paradigmatic problems in enzymology, metalloproteins, photosynthesis and computer-aided drug design. With this review, we hope to demonstrate that first principles modelling of biological structure-function relationships are approaching a reality. PMID:27494095

  19. Applications of large-scale density functional theory in biology

    Science.gov (United States)

    Cole, Daniel J.; Hine, Nicholas D. M.

    2016-10-01

    Density functional theory (DFT) has become a routine tool for the computation of electronic structure in the physics, materials and chemistry fields. Yet the application of traditional DFT to problems in the biological sciences is hindered, to a large extent, by the unfavourable scaling of the computational effort with system size. Here, we review some of the major software and functionality advances that enable insightful electronic structure calculations to be performed on systems comprising many thousands of atoms. We describe some of the early applications of large-scale DFT to the computation of the electronic properties and structure of biomolecules, as well as to paradigmatic problems in enzymology, metalloproteins, photosynthesis and computer-aided drug design. With this review, we hope to demonstrate that first principles modelling of biological structure-function relationships are approaching a reality.

  20. 7 CFR 51.33 - Application to become a licensed inspector.

    Science.gov (United States)

    2010-01-01

    ... handwriting, and the application shall contain or be accompanied by: (a) A statement of present address, age... inspectors; and (d) Such other information as may be required by the Administrator. ... Section 51.33 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING...

  1. 75 FR 45200 - Commercial Driver's License (CDL) Standards; Rotel North American Tours, LLC; Application for...

    Science.gov (United States)

    2010-08-02

    ... that the quality of its tour service was affected adversely. Rotel believes that each of these drivers... North American Tours, LLC; Application for Renewal of Exemption AGENCY: Federal Motor Carrier Safety... drivers of Rotel North American Tours, LLC (Rotel) to enable them to operate commercial motor...

  2. 76 FR 76193 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2011-12-06

    ... Tube Failure (PWR).'' The primary loop components (e.g., reactor vessel, reactor internals, control rod drive housings, piping and supports, and reactor coolant pumps) remain within their applicable... rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve...

  3. 77 FR 8288 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2012-02-14

    ... the AREVA 16x16 reactor fuel on a ] permanent basis in San Onofre Nuclear Generating Station (SONGS... an AOO from the limiting condition of operation, at least 99.9% of the fuel rods in the core would be... derived from the dual loop SLMCPR value. Based on the application of Global Nuclear Fuels' NRC...

  4. 77 FR 12830 - Pershing County Water Conservation District; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2012-03-02

    ... Energy Regulatory Commission Pershing County Water Conservation District; Notice of Intent To File....: 14327-000. c. Date Filed: November 22, 2011. d. Submitted by: Pershing County Water Conservation... Applicant Contact: Bennie Hodges, Pershing County Water Conservation District, P.O. Box 218, Lovelock,...

  5. 78 FR 50139 - Commercial Driver's License Standards: Application for Exemption; Miami Nice Tours

    Science.gov (United States)

    2013-08-16

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Participation... Exemption; Miami Nice Tours AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of application for exemption; request for comments. SUMMARY: FMCSA announces that Miami Nice...

  6. 77 FR 10491 - Progress Energy Carolinas, Inc.; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2012-02-22

    .... d. Applicant: Progress Energy Carolinas, Inc. e. Name of Project: Yadkin-Pee Dee Hydroelectric... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact information at the end of your comments. For assistance, please contact FERC Online Support at...

  7. 76 FR 28016 - Progress Energy Carolinas, Inc.; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2011-05-13

    ... 29, 2011. d. Applicant: Progress Energy Carolinas, Inc. e. Name of Project: Yadkin-Pee Dee Hydroelectric Project. f. Location: The Pee Dee River in Stanly County, North Carolina. g. Filed Pursuant to... include your name and contact information at the end of your comments. Please include the project...

  8. The Monticello license renewal project

    International Nuclear Information System (INIS)

    Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

  9. 1,2,4-triazine derivatives: Synthesis and biological applications

    Directory of Open Access Journals (Sweden)

    Mohammad Arshad

    2014-04-01

    Full Text Available 1,2,4-Triazines are the six membered heterocyclic compounds possessing three nitrogen in its structure with general formula C3H3N3. 1,2,4-Triazines and its derivatives have been found to exhibit the variety of biological applications such as antifungal, anti-HIV, anticancer, antiinflammatory, analgesic and antihypertensive, cardiotonic, neuroleptic, nootropic, antihistaminergic, tuberculostatic, antiviral, anti-protozoal, estrogen receptor modulators, antimalarial, cyclin-dependent kinase inhibitors, antimicrobial and antiparasitic activities.

  10. 1,2,4-triazine derivatives: Synthesis and biological applications

    OpenAIRE

    Mohammad Arshad; Taki Ahmed Khan; Meraj Alam Khan

    2014-01-01

    1,2,4-Triazines are the six membered heterocyclic compounds possessing three nitrogen in its structure with general formula C3H3N3. 1,2,4-Triazines and its derivatives have been found to exhibit the variety of biological applications such as antifungal, anti-HIV, anticancer, antiinflammatory, analgesic and antihypertensive, cardiotonic, neuroleptic, nootropic, antihistaminergic, tuberculostatic, antiviral, anti-protozoal, estrogen receptor modulators, antimalarial, cyclin-dependent kinase inh...

  11. Applications of electrochemistry and nanotechnology in biology and medicine II

    CERN Document Server

    Eliaz, Noam

    2011-01-01

    The study of electrochemical nanotechnology has emerged as researchers apply electrochemistry to nanoscience and nanotechnology. These two related volumes in the Modern Aspects of Electrochemistry Series review recent developments and breakthroughs in the specific application of electrochemistry and nanotechnology to biology and medicine. Internationally renowned experts contribute chapters that address both fundamental and practical aspects of several key emerging technologies in biomedicine, such as the processing of new biomaterials, biofunctionalization of surfaces, characterization of bio

  12. Environmental Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Environmental report

    International Nuclear Information System (INIS)

    The Environmental Standard Review Plan (ESRP) (NUREG-1300) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform environmental reviews of environmental reports prepared by applicants in support of license applications to construct and operate new low-level radioactive waste disposal facilities. The individual ESRPs that constitute this document identify the information considered necessary to conduct the review, the purpose and scope of the review, the analysis procedure and evaluation, the formal input to the environmental statement, and the references considered appropriate for each review. The ESRP is intended to ensure quality and uniformity of approach in individual reviews as well as compliance with the National Environmental Policy Act of 1969. In addition, the ESRP will make information about the environmental component of the licensing process more readily available and thereby will serve to improve the understanding of this process among the public, States and regional compacts, and the regulated community

  13. 12 CFR 263.56 - Initial Licensing Proceedings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Initial Licensing Proceedings. 263.56 Section... Licensing Proceedings. Proceedings with respect to applications for initial licenses shall include, but not... initial licensing proceedings, the procedures set forth in subpart A of this part shall apply, except...

  14. 18 CFR 5.16 - Preliminary licensing proposal.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary licensing... Preliminary licensing proposal. (a) No later than 150 days prior to the deadline for filing a new or... licensing proposal. (b) The preliminary licensing proposal must: (1) Clearly describe, as applicable,...

  15. 7 CFR 4290.390 - Licensing as a RBIC.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Licensing as a RBIC. 4290.390 Section 4290.390... Evaluation and Selection of RBICs § 4290.390 Licensing as a RBIC. (a) Eligibility criteria for licensing as a... a Participation Agreement with the Secretary. (b) Licensing as a RBIC. If the selected Applicant...

  16. 10 CFR 52.109 - Continuation of combined license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Continuation of combined license. 52.109 Section 52.109... POWER PLANTS Combined Licenses § 52.109 Continuation of combined license. Each combined license for a... applicable to the facility in accordance with the NRC's regulations and the provisions of the...

  17. 10 CFR 52.167 - Issuance of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Issuance of manufacturing license. 52.167 Section 52.167... POWER PLANTS Manufacturing Licenses § 52.167 Issuance of manufacturing license. (a) After completing any... manufacturing license if the Commission finds that: (1) Applicable standards and requirements of the Act and...

  18. 10 CFR 51.54 - Environmental report-manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-manufacturing license. 51.54 Section... report—manufacturing license. (a) Each applicant for a manufacturing license under subpart F of part 52... Environmental Report—Manufacturing License.” The environmental report must address the costs and benefits...

  19. Edwin I. Hatch Nuclear Plant, Unit 2. License application, general information

    International Nuclear Information System (INIS)

    An application for a direct cycle BWR is presented. The reactor will be located about 11 miles north of Baxley, Ga., near the south bank of the Ultamaha River in Appling County close to Hatch-1 Reactor. The core thermal power level will be 2537 MW(t) and the electrical power level will be 795 MW(e). Mechanical cooling towers will be utilized

  20. Black Fox Station, Units 1 and 2. Application for construction permits and operating licenses

    International Nuclear Information System (INIS)

    An application to construct and operate Black Fox Station, Units 1 and 2, is presented. The two BWR type reactors will have a rated core thermal power of 3579 MW(t) and a net electrical power of approximately 1150 MW(e). The facility will be located in Inola Township, 23 miles east of Tulsa on the east side of the Verdigris River in Rogers County, Oklahoma

  1. Marble Hill Nuclear Generating Station, Units 1 and 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    An application is presented for two PWR reactors to be constructed in Salud Township, Jefferson County, Indiana, about six miles northeast of New Washington on the Ohio River. Each unit will have a rated core power level of 3411 MW(t) with a corresponding electrical output of 1130 MW(e). Mechanical draft cooling towers will be provided. The facility, which will replicate the Byron facility will be employed for the generation of electricity for transmission, sale for resale, and distribution

  2. Practical automatic Arabic license plate recognition system

    Science.gov (United States)

    Mohammad, Khader; Agaian, Sos; Saleh, Hani

    2011-02-01

    Since 1970's, the need of an automatic license plate recognition system, sometimes referred as Automatic License Plate Recognition system, has been increasing. A license plate recognition system is an automatic system that is able to recognize a license plate number, extracted from image sensors. In specific, Automatic License Plate Recognition systems are being used in conjunction with various transportation systems in application areas such as law enforcement (e.g. speed limit enforcement) and commercial usages such as parking enforcement and automatic toll payment private and public entrances, border control, theft and vandalism control. Vehicle license plate recognition has been intensively studied in many countries. Due to the different types of license plates being used, the requirement of an automatic license plate recognition system is different for each country. [License plate detection using cluster run length smoothing algorithm ].Generally, an automatic license plate localization and recognition system is made up of three modules; license plate localization, character segmentation and optical character recognition modules. This paper presents an Arabic license plate recognition system that is insensitive to character size, font, shape and orientation with extremely high accuracy rate. The proposed system is based on a combination of enhancement, license plate localization, morphological processing, and feature vector extraction using the Haar transform. The performance of the system is fast due to classification of alphabet and numerals based on the license plate organization. Experimental results for license plates of two different Arab countries show an average of 99 % successful license plate localization and recognition in a total of more than 20 different images captured from a complex outdoor environment. The results run times takes less time compared to conventional and many states of art methods.

  3. Chitooligosaccharide and Its Derivatives: Preparation and Biological Applications

    Directory of Open Access Journals (Sweden)

    Gaurav Lodhi

    2014-01-01

    Full Text Available Chitin is a natural polysaccharide of major importance. This biopolymer is synthesized by an enormous number of living organisms; considering the amount of chitin produced annually in the world, it is the most abundant polymer after cellulose. The most important derivative of chitin is chitosan, obtained by partial deacetylation of chitin under alkaline conditions or by enzymatic hydrolysis. Chitin and chitosan are known to have important functional activities but poor solubility makes them difficult to use in food and biomedicinal applications. Chitooligosaccharides (COS are the degraded products of chitosan or chitin prepared by enzymatic or chemical hydrolysis of chitosan. The greater solubility and low viscosity of COS have attracted the interest of many researchers to utilize COS and their derivatives for various biomedical applications. In light of the recent interest in the biomedical applications of chitin, chitosan, and their derivatives, this review focuses on the preparation and biological activities of chitin, chitosan, COS, and their derivatives.

  4. Liquid Exfoliation of Layered Transition Metal Dichalcogenides for Biological Applications.

    Science.gov (United States)

    Nguyen, Emily P; Daeneke, Torben; Zhuiykov, Serge; Kalantar-Zadeh, Kourosh

    2016-06-02

    Known to possess distinctive properties that differ greatly from their bulk form, layered two-dimensional materials have been extensively studied and incorporated into many versatile applications ranging from optoelectronics to sensors. For biomedical research, two-dimensional transition metal dichalcogenides (2D TMDs) have garnered much interest as they have been shown to exhibit relatively low toxicity, high stability in aqueous environments, and the ability to adhere to biological materials such as proteins. These materials are promising candidates, demonstrating potential applications in biosensing, cell imaging, diagnostics, and therapeutics. Preparation and exfoliation of 2D TMDs play an important part in these various applications as their properties are heavily dependent on the number of layers and lateral size. Described in this article are protocols for the liquid exfoliation of 2D TMDs from their bulk materials. Additional protocols are also provided for functionalizing or modifying the surface of the exfoliated 2D TMDs. © 2016 by John Wiley & Sons, Inc.

  5. Classical and spatial stochastic processes with applications to biology

    CERN Document Server

    Schinazi, Rinaldo B

    2014-01-01

    The revised and expanded edition of this textbook presents the concepts and applications of random processes with the same illuminating simplicity as its first edition, but with the notable addition of substantial modern material on biological modeling. While still treating many important problems in fields such as engineering and mathematical physics, the book also focuses on the highly relevant topics of cancerous mutations, influenza evolution, drug resistance, and immune response. The models used elegantly apply various classical stochastic models presented earlier in the text, and exercises are included throughout to reinforce essential concepts. The second edition of Classical and Spatial Stochastic Processes is suitable as a textbook for courses in stochastic processes at the advanced-undergraduate and graduate levels, or as a self-study resource for researchers and practitioners in mathematics, engineering, physics, and mathematical biology. Reviews of the first edition: An appetizing textbook for a f...

  6. Application of enriched stable isotopes as tracers in biological systems

    DEFF Research Database (Denmark)

    Stürup, Stefan; Hansen, Helle Rüsz; Gammelgaard, Bente

    2008-01-01

    The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry...... (ICP-MS) instrumentation, such as reaction/collision cell ICP-MS and multicollector ICP-MS with improved isotope ratio measurement and interference removal capabilities. Adaptation and refinement of radioisotope tracer experiment methodologies for enriched stable isotope experiments......, and the development of new methodologies coupled with more advanced compartmental and mathematical models for the distribution of elements in living organisms has enabled a broader use of enriched stable isotope experiments in the biological sciences. This review discusses the current and future uses of enriched...

  7. 10 CFR 52.8 - Combining licenses; elimination of repetition.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Combining licenses; elimination of repetition. 52.8... NUCLEAR POWER PLANTS General Provisions § 52.8 Combining licenses; elimination of repetition. (a) An applicant for a license under this part may combine in its application several applications for...

  8. Pulsed electrical discharges for medicine and biology techniques, processes, applications

    CERN Document Server

    Kolikov, Victor

    2015-01-01

    This book presents the application of pulsed electrical discharges in water and water dispersions of metal nanoparticles in medicine (surgery, dentistry, and oncology), biology, and ecology. The intensive electrical and shock waves represent a novel technique to destroy viruses and this way to  prepare anti-virus vaccines. The method of pulsed electrical discharges in water allows to decontaminate water from almost all known bacteria and spores of fungi being present in human beings. The nanoparticles used are not genotoxic and mutagenic. This book is useful for researchers and graduate students.

  9. Applications of Chitin and Its Derivatives in Biological Medicine

    Directory of Open Access Journals (Sweden)

    Moon-Moo Kim

    2010-12-01

    Full Text Available Chitin and its derivatives—as a potential resource as well as multiple functional substrates—have generated attractive interest in various fields such as biomedical, pharmaceutical, food and environmental industries, since the first isolation of chitin in 1811. Moreover, chitosan and its chitooligosaccharides (COS are degraded products of chitin through enzymatic and acidic hydrolysis processes; and COS, in particular, is well suited for potential biological application, due to the biocompatibility and nontoxic nature of chitosan. In this review, we investigate the current bioactivities of chitin derivatives, which are all correlated with their biomedical properties. Several new and cutting edge insights here may provide a molecular basis for the mechanism of chitin, and hence may aid its use for medical and pharmaceutical applications.

  10. Human Metabolic Network: Reconstruction, Simulation, and Applications in Systems Biology

    Science.gov (United States)

    Wu, Ming; Chan, Christina

    2012-01-01

    Metabolism is crucial to cell growth and proliferation. Deficiency or alterations in metabolic functions are known to be involved in many human diseases. Therefore, understanding the human metabolic system is important for the study and treatment of complex diseases. Current reconstructions of the global human metabolic network provide a computational platform to integrate genome-scale information on metabolism. The platform enables a systematic study of the regulation and is applicable to a wide variety of cases, wherein one could rely on in silico perturbations to predict novel targets, interpret systemic effects, and identify alterations in the metabolic states to better understand the genotype-phenotype relationships. In this review, we describe the reconstruction of the human metabolic network, introduce the constraint based modeling approach to analyze metabolic networks, and discuss systems biology applications to study human physiology and pathology. We highlight the challenges and opportunities in network reconstruction and systems modeling of the human metabolic system. PMID:24957377

  11. Micro-segmented flow applications in chemistry and biology

    CERN Document Server

    Cahill, Brian

    2014-01-01

    The book is dedicated to the method and application potential of micro segmented flow. The recent state of development of this powerful technique is presented in 12 chapters by leading researchers from different countries. In the first section, the principles of generation and manipulation of micro-fluidic segments are explained. In the second section, the micro continuous-flow synthesis of different types of nanomaterials is shown as a typical example for the use of advantages of the technique in chemistry. In the third part, the particular importance of the technique in biotechnical applications is presented demonstrating the progress for miniaturized cell-free processes, for molecular biology and DNA-based diagnostis and sequencing as well as for the development of antibiotics and the evaluation of toxic effects in medicine and environment.

  12. Licensing and Business Models

    OpenAIRE

    Onetti Alberto; Verma Sameer

    2008-01-01

    License affects software companies’ business activities. While proprietary software vendors create custom licenses, open source companies have less flexibility. The Open Source Initiative (OSI) defines a list of 72 licenses as open source (“OSI approved”). For a project to follow open source licensing, it has to pick licenses from this set. Logically, we expect that an open source company defines its business model around the license that it selects. Thus, we can assume that business model de...

  13. Review on thin-film transistor technology, its applications, and possible new applications to biological cells

    Science.gov (United States)

    Tixier-Mita, Agnès; Ihida, Satoshi; Ségard, Bertrand-David; Cathcart, Grant A.; Takahashi, Takuya; Fujita, Hiroyuki; Toshiyoshi, Hiroshi

    2016-04-01

    This paper presents a review on state-of-the-art of thin-film transistor (TFT) technology and its wide range of applications, not only in liquid crystal displays (TFT-LCDs), but also in sensing devices. The history of the evolution of the technology is first given. Then the standard applications of TFT-LCDs, and X-ray detectors, followed by state-of-the-art applications in the field of chemical and biochemical sensing are presented. TFT technology allows the fabrication of dense arrays of independent and transparent microelectrodes on large glass substrates. The potential of these devices as electrical substrates for biological cell applications is then described. The possibility of using TFT array substrates as new tools for electrical experiments on biological cells has been investigated for the first time by our group. Dielectrophoresis experiments and impedance measurements on yeast cells are presented here. Their promising results open the door towards new applications of TFT technology.

  14. Nursing: Licensed Practical and Licensed Vocational Nurses

    Science.gov (United States)

    ... LPNs) and licensed vocational nurses (LVNs) provide basic nursing care. They work under the direction of registered ... licensed vocational nurses work in many settings, including nursing homes and extended care facilities, hospitals, physicians’ offices, ...

  15. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  16. Ultrasensitive Force Detection and Applications to Biological Systems

    Science.gov (United States)

    Kenny, Thomas

    2001-03-01

    For many years, researchers have developed a variety of micromechanical devices for a range of applications. The majority of these devices are based on micromechanical force transducers to convert external physical signals into electrical signals. The force sensing capabilities of these devices are remarkable - it is possible to design devices with force resolution ranging from milli-N to atto-N within this technology. In addition to the conventional applications for MEMS devices, it is possible to tailor these designs to allow interesting scientific measurements on biological systems. For example, there are active research communities investigating cellular adhesion, protein folding, and animal locomotion. In all of these cases, the basic questions are mechanical in nature, and direct force measurements can provide new insight. This talk will review some ongoing biological research that makes use of MEMS devices, and discuss opportunities for new directions. Collaborators on this research include : Yiching Liang, Robert Rudnitsky, Michael Bartsch, Robert Full, Kellar Autumn, James Nelson, Jim Spudich, and Mark Cutkosky This work is funded by NSF (XYZ on a Chip) and ONR MURI (Biomimetic Robots).

  17. 77 FR 60419 - Lock + Hydro Friends Fund XIX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-10-03

    ... Energy Regulatory Commission Lock + Hydro Friends Fund XIX, LLC; Notice of Intent To File License... Friends Fund XIX, LLC. e. Name of Project: Claiborne Hydroelectric Project. f. Location: At the U.S. Army... email at rachel.mcnamara@ferc.gov . j. Lock + Hydro Friends Fund XIX, LLC filed its request to use...

  18. 77 FR 16217 - Lock+ Hydro Friends Fund XXXIX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-03-20

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XXXIX, LLC; Notice of Intent To File License... Friends Fund XXXIX, LLC. e. Name of Project: C.W. Bill Young Lock and Dam Hydroelectric Project. f... R. Stover, Lock+\\TM\\ Hydro Friends Fund XXXIX, c/o Hydro Green Energy, LLC, 900 Oakmont Lane,...

  19. 77 FR 9222 - Lock+ Hydro Friends Fund XLII, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-02-16

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XLII, LLC; Notice of Intent To File License... Friends Fund XLII, LLC. e. Name of Project: Braddock Locks and Dam Hydroelectric Project. f. Location: At..., Lock+\\TM\\ Hydro Friends Fund XLII, c/o Hydro Green Energy, LLC, 900 Oakmont Lane, Suite 310,...

  20. 77 FR 62500 - Peabody Trout Creek Reservoir LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-10-15

    ... Energy Regulatory Commission Peabody Trout Creek Reservoir LLC; Notice of Intent To File License...: Peabody Trout Creek Reservoir LLC. e. Name of Project: Trout Creek Reservoir Hydroelectric Project. f. Location: On Trout Creek, 15 miles southwest of Steamboat Springs, Colorado. The project occupies 4.3...

  1. 78 FR 5508 - Vogtle Electric Generating Plant, Units 3 and 4; Application and Amendment to Combined Licenses...

    Science.gov (United States)

    2013-01-25

    ....regulations.gov and search for Docket ID NRC-2008-0252. NRC's Agencywide Documents Access and Management...) to clarify the requirements for shear reinforcement spacing in the nuclear island basemat below the... reinforcement in the basemat below the auxiliary building. Before issuance of the proposed license...

  2. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-04-18

    ... Federal Energy Regulatory Commission Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License... Friends Fund XXX, LLC. e. Name of Project: New Cumberland Locks and Dam Hydroelectric Project. f. Location... XXX, c/o Hydro Green Energy, LLC, 900 Oakmont Lane, Suite 310, Westmont, IL 60559; (877) 556-6566...

  3. Texas site selection and licensing status

    Energy Technology Data Exchange (ETDEWEB)

    Avant, R.V. Jr.

    1989-11-01

    Texas has identified a potential site in Hudspeth County in far West Texas near the town of Fort Hancock. Over the past year the Texas Low-Level Radioactive Waste Disposal Authority has been conducting detailed geology, hydrology, meteorology, soils, and flora and fauna evaluations. An authorization by the Board of Directors of the Authority to proceed with a license application, assuming that the detailed evaluation indicates that the site is suitable, is expected by September. A prototype license has been prepared in anticipation of the order to proceed with licensing, and the formal license application is expected to be submitted to the Texas Department of Health-Bureau of Radiation Control in December, meeting the license application milestone. Although site selection processes in all siting areas across the country have experienced organized opposition, El Paso County has funded a particularly well-organized, well-financed program to legally and technically stop consideration of the Fort Hancock site prior to the licensing process. Many procedural, regulatory, and technical issues have been raised which have required responses from the Authority in order to proceed with licensing. This has provided a unique perspective of what to expect from well-organized opposition at the licensing stage. This paper presents an update on the Texas siting activity with detailed information on the site evaluation and license application. Experience of dealing with issues raised by opposition relating to NRC guidelines and rules is also discussed.

  4. Licensing an assured isolation facility for low-level radioactive waste. Volume 1: Licensing strategy and issues

    International Nuclear Information System (INIS)

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  5. Advanced carbon manufacturing for energy and biological applications

    Science.gov (United States)

    Turon Teixidor, Genis

    The science of miniaturization has experienced revolutionary advances during the last decades, witnessing the development of the Integrated Circuit and the emergence of MEMS and Nanotechnology. Particularly, MEMS technology has pioneered the use of non-traditional materials in microfabrication by including polymers, ceramics and composites to the well known list of metals and semiconductors. One of the latest additions to this set of materials is carbon, which represents a very important inclusion given its significance in electrochemical energy conversion systems and in applications where it is used as sensor probe material. For these applications, carbon is optimal in several counts: It has a wide electrochemical stability window, good electrical and thermal conductivity, high corrosion resistance and mechanical stability, and is available in high purity at a low cost. Furthermore carbon is biocompatible. This thesis presents several microfabricated devices that take advantage of these properties. The thesis has two clearly differentiated parts. In the first one, applications of micromachined carbon in the field of energy conversion and energy storage are presented. These applications include lithium ion micro batteries and the development of new carbon electrodes with fractal geometries. In the second part, the focus shifts to biological applications. First, the study of the interaction of living cells with micromachined carbon is presented, followed by the description of a sensor based on interdigitated nano-electrode arrays, and finally the development of the new instrumentation needed to address arrays of carbon electrodes, a multiplexed potentiostat. The underlying theme that connects all these seemingly different topics is the use of carbon microfabrication techniques in electrochemical systems.

  6. 10 CFR 81.32 - Terms of exclusive license grant.

    Science.gov (United States)

    2010-01-01

    ... wholly owned subsidiaries of the licensee but shall be nonassignable and otherwise nontransferable... LICENSES Nrc-Owned Inventions-Patents and Applications § 81.32 Terms of exclusive license grant. (a)...

  7. Generic evaluation of feedwater transients and small break loss-of-coolant accidents in GE-designed operating plants and near-term operating license applications

    International Nuclear Information System (INIS)

    The results are presented of a generic evaluation of feedwater transients, small-break loss-of-coolant accidents (LOCAs), and other TMI-2-related events for General Electric Company (GE)-designed operating plants and near-term operating license applications to confirm or establish the bases for the continued safe operation of the operating plants. The results of this evaluation are presented in this report in the form of a set of findings and recommendations in each of the principal review areas. Additional review of the accident is continuing and further information is being obtained and evaluated. Any new information will be reviewed and modifications will be made as appropriate

  8. Models to Study NK Cell Biology and Possible Clinical Application.

    Science.gov (United States)

    Zamora, Anthony E; Grossenbacher, Steven K; Aguilar, Ethan G; Murphy, William J

    2015-08-03

    Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. NK cells rapidly recognize and respond to abnormal cells in the absence of prior sensitization due to their wide array of germline-encoded inhibitory and activating receptors, which differs from the receptor diversity found in B and T lymphocytes that is due to the use of recombination-activation gene (RAG) enzymes. Although NK cells have traditionally been described as natural killers that provide a first line of defense prior to the induction of adaptive immunity, a more complex view of NK cells is beginning to emerge, indicating they may also function in various immunoregulatory roles and have the capacity to shape adaptive immune responses. With the growing appreciation for the diverse functions of NK cells, and recent technological advancements that allow for a more in-depth understanding of NK cell biology, we can now begin to explore new ways to manipulate NK cells to increase their clinical utility. In this overview unit, we introduce the reader to various aspects of NK cell biology by reviewing topics ranging from NK cell diversity and function, mouse models, and the roles of NK cells in health and disease, to potential clinical applications. © 2015 by John Wiley & Sons, Inc.

  9. Applications of Inorganic Chemistry in Biology: An Interdisciplinary Graduate Course

    Science.gov (United States)

    Farrell, Nicholas; Ross, Paul; Roat, Rosette M.

    1998-06-01

    Inorganic chemistry faculty at Virginia Commonwealth University (VCU) are offering an advanced, interdisciplinary, graduate course entitled "Applications of Inorganic Chemistry in Biology". The course utilizes examples from bioinorganic chemistry to introduce advanced topics in synthesis, structural analysis, and analytical methods that are practiced by inorganic chemists. Emphasis is placed on the structure and function of trace and ultratrace transition metals in biological systems and on the use of metals for medicinal purposes. Instrumental techniques such as electron paramagnetic resonance, Mössbauer spectroscopy, and X-ray crystallography are explained in the detail necessary to familiarize students with their use for analysis of bioinorganic systems and their models. Students have take-home examinations during the term and write a term paper describing a metalloprotein whose X-ray structure data is listed in Brookhaven protein data base. The paper follows the same course pattern of classroom discussion of a bioinorganic system, concentrating on the coordination geometry and nearest neighbor contacts of the metal-binding site in the protein, substrate binding site, and relevance to the metalloprotein or enzyme function, mechanism of action of the enzyme or protein, spectroscopic studies on the metal-binding site, and model studies for the protein's metal-binding site. The instructors conclude that their basic goals for the course - introduction to advanced inorganic chemistry topics using bioinorganic examples with emphasis on primary literature sources and computer-assisted displays - are being accomplished.

  10. A poroelastic immersed boundary method with applications to cell biology

    Science.gov (United States)

    Strychalski, Wanda; Copos, Calina A.; Lewis, Owen L.; Guy, Robert D.

    2015-02-01

    The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In the traditional immersed boundary method, the fluid and structure move with the same velocity field. In this work, a model based on the immersed boundary method is presented for simulating poroelastic media in which the fluid permeates a porous, elastic structure of small volume fraction that moves with its own velocity field. Two distinct methods for calculating elastic stresses are presented and compared. The methods are validated on a radially symmetric test problem by comparing with a finite difference solution of the classical equations of poroelasticity. Finally, two applications of the modeling framework to cell biology are provided: cellular blebbing and cell crawling. It is shown that in both examples, poroelastic effects are necessary to explain the relevant mechanics.

  11. Stochasticity in processes fundamentals and applications to chemistry and biology

    CERN Document Server

    Schuster, Peter

    2016-01-01

    This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed t...

  12. Biology and Industrial Applications of Chlorella: Advances and Prospects.

    Science.gov (United States)

    Liu, Jin; Chen, Feng

    2016-01-01

    Chlorella represents a group of eukaryotic green microalgae that has been receiving increasing scientific and commercial interest. It possesses high photosynthetic ability and is capable of growing robustly under mixotrophic and heterotrophic conditions as well. Chlorella has long been considered as a source of protein and is now industrially produced for human food and animal feed. Chlorella is also rich in oil, an ideal feedstock for biofuels. The exploration of biofuel production by Chlorella is underway. Chlorella has the ability to fix carbon dioxide efficiently and to remove nutrients of nitrogen and phosphorous, making it a good candidate for greenhouse gas biomitigation and wastewater bioremediation. In addition, Chlorella shows potential as an alternative expression host for recombinant protein production, though challenges remain to be addressed. Currently, omics analyses of certain Chlorella strains are being performed, which will help to unravel the biological implications of Chlorella and facilitate the future exploration of industrial applications.

  13. Normal mode analysis and applications in biological physics

    Energy Technology Data Exchange (ETDEWEB)

    Dykeman, Eric C; Sankey, Otto F [Department of Physics, Center for Biological Physics, Arizona State University, Tempe, AZ 85287-1504 (United States)

    2010-10-27

    Normal mode analysis has become a popular and often used theoretical tool in the study of functional motions in enzymes, viruses, and large protein assemblies. The use of normal modes in the study of these motions is often extremely fruitful since many of the functional motions of large proteins can be described using just a few normal modes which are intimately related to the overall structure of the protein. In this review, we present a broad overview of several popular methods used in the study of normal modes in biological physics including continuum elastic theory, the elastic network model, and a new all-atom method, recently developed, which is capable of computing a subset of the low frequency vibrational modes exactly. After a review of the various methods, we present several examples of applications of normal modes in the study of functional motions, with an emphasis on viral capsids. (topical review)

  14. Modular Verification of Interactive Systems with an Application to Biology

    Directory of Open Access Journals (Sweden)

    P. Milazzo

    2011-01-01

    Full Text Available We propose sync-programs, an automata-based formalism for the description of biological systems, and a modular verification technique for such a formalism that allows properties expressed in the universal fragment of CTL to be verified on suitably chosen fragments of models, rather than on whole models. As an application we show the modelling of the lac operon regulation process and the modular verification of some properties. Verification of properties is performed by using the NuSMV model checker and we show that by applying our modular verification technique we can verify properties in shorter times than those necessary to verify the same properties in the whole model.

  15. Various On-Chip Sensors with Microfluidics for Biological Applications

    Directory of Open Access Journals (Sweden)

    Hun Lee

    2014-09-01

    Full Text Available In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR and surface-enhanced Raman scattering (SERS to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV and greater depth of field (DOF. As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

  16. The pre-licensing of a multi-purpose hybrid research reactor for high-tech applications 'MYRRHA'

    Energy Technology Data Exchange (ETDEWEB)

    Hakimi, N.; Dams, C.; Wertelaers, A.; Nys, V.; Schrauben, M.; Dresselaers, R. [Federal Agency for Nuclear Control (FANC-AFCN), Brussels (Belgium). Nuclear Facilities and Waste Dept. and Security and Transport Dept.

    2013-02-15

    The Belgian Nuclear Research Centre in Mol has been working for several years on the design of a multi-purpose flexible irradiation facility in order to replace the ageing BR2, a multipurpose materials testing reactor (MTR), in operation since 1962. MYRRHA, a flexible fast spectrum research reactor is conceived as an accelerator driven system (ADS), able to operate in sub-critical and critical modes. It contains a proton accelerator of 600 MeV, a spallation target and a multiplying medium with MOX fuel, cooled by liquid lead-bismuth (Pb-Bi). Since February 2011, the Belgian Nuclear Research Centre has engaged in a 'pre-licensing' process with the regulatory authority for an estimated period up to mid 2014. The paper presents on the one hand the objectives of the pre-licensing phase as well as its implementation process and on the other hand, 2 implementing instruments which have been developed by the regulatory authority providing guidance to the designer of MYRRHA in order to meet the pre-licensing phase objectives. The first instrument is a strategic note for the design and operation of MYRRHA where as the second instrument is a guidance document for the format and content of a design options and provisions file (DOPF). Both instruments have been developed taking into account that MYRRHA is an irradiation facility using a Generation IV nuclear power system's type technology (liquid metal cooled fast neutron reactor). The strategic note overview aims to cover the safety approach as well as the security requirements and safeguards obligation applicable to MYRRHA. In particular, in the strategic note, a specific attention has been paid in order to ensure that a safety, security and safeguards integrated approach will drive the development of the MYRRHA design. The safety approach focuses on the safety goals and the minimum safety objectives set by the regulatory authority for this innovative design. The DOPF overview presents its objectives and

  17. A novel POSS-coated quantum dot for biological application

    Directory of Open Access Journals (Sweden)

    Rizvi SB

    2012-08-01

    Full Text Available Sarwat B Rizvi,1 Lara Yildirimer,1 Shirin Ghaderi,1 Bala Ramesh,1 Alexander M Seifalian,1,2 Mo Keshtgar1,21UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, United Kingdom; 2Royal Free Hampstead NHS Trust Hospital, London, United KingdomAbstract: Quantum dots (QDs are fluorescent semiconductor nanocrystals that have the potential for major advancements in the field of nanomedicine through their unique photophysical properties. They can potentially be used as fluorescent probes for various biomedical imaging applications, including cancer localization, detection of micrometastasis, image guided surgery, and targeted drug delivery. Their main limitation is toxicity, which requires a biologically compatible surface coating to shield the toxic core from the surrounding environment. However, this leads to an increase in QD size that may lead to problems of excretion and systemic sequestration. We describe a one pot synthesis, characterization, and in vitro cytotoxicity of a novel polyhedral oligomeric silsesquioxane (POSS-coated CdTe-cored QD using mercaptosuccinic acid (MSA and D-cysteine as stabilizing agents. Characterization was performed using transmission electron microscopy Fourier transform infrared spectroscopy, and photoluminescence studies. POSS-coated QDs demonstrated high colloidal stability and enhanced photostability on high degrees of ultraviolet (UV excitation compared to QDs coated with MSA and D-cysteine alone (P value < 0.05. In vitro toxicity studies showed that both POSS and MSA-QDs were significantly less toxic than ionized salts of Cd+2 and Te-2. Confocal microscopy confirmed high brightness of POSS-QDs in cells at both 1 and 24 hours, indicating that these QDs are rapidly taken up by cells and remain photostable in a biological environment. We therefore conclude that a POSS coating confers biological compatibility, photostability, and colloidal

  18. Applications of dynamical systems to economical and biological sciences

    OpenAIRE

    Ferreira, Luís Miguel Mesquita da Silva

    2010-01-01

    Tese de doutoramento em Ciências (ramo de conhecimento em Matemática) In this PhD thesis, several concepts of distinct areas of Mathematics, such as Dynamical Systems, Game Theory and Statistics are applied to Economical and Biomedical Sciences. The Patent Licensing is studied in a Cournot competition framework, the General Equilibrium Theory is approached in terms of Edgeworthian economies and the subject of Immunology is covered through models with Regulatory T cells. C...

  19. Overview of the Yucca Mountain Licensing Process

    International Nuclear Information System (INIS)

    This paper presents an overview of the licensing process for a Yucca Mountain repository for high-level radioactive waste and spent nuclear fuel. The paper discusses the steps in the licensing proceeding, the roles of the participants, the licensing and hearing requirements contained in the Code of Federal Regulations. A description of the Nuclear Regulatory Commission (NRC) staff acceptance and compliance reviews of the Department of Energy (DOE) application for a construction authorization and a license to receive and possess high-level radioactive waste and spent nuclear fuel is provided. The paper also includes a detailed description of the hearing process

  20. Polyhydroyalkanoates: from Basic Research and Molecular Biology to Application

    Directory of Open Access Journals (Sweden)

    Amro Abd alFattah Amara

    2010-09-01

    Full Text Available This review describes the Polyhydroxyalkanoate (PHA, an intracellular biodegradable microbial polymer. PHAs is formed from different types of three hydroxyalkanoic acids monomers, each unit forms an ester bond with the hydroxyl group of the other one and the hydroxyl substituted carbon has R configuration. The C-3 atom in β position is branched with at least one carbon atom in the form of methyl group (C1 to thirteen carbons in the form of tridecyl (C13. This alkyl side chain is not necessarily saturated. PHAs are biosynthesized through regulated pathways by specific enzymes. PHAs are accumulated in bacterial cells from soluble to insoluble form as storage materials inside the inclusion bodies during unbalanced nutrition or to save organisms from reducing equivalents. PHAs are converted again to soluble components by PHAs depolymerases and the degraded materials enter various metabolic pathways. Until now, four classes of enzymes responsible for PHAs polymerization are known. PHAs were well studied regarding their promising applications, physical, chemical and biological properties. PHAs are biodegradable, biocompatible, have good material properties, renewable and can be used in many applications. The most limiting factor in PHAs commercialization is their high cost compared to the petroleum plastics. This review highlights the new knowledge and that established by the pioneers in this field as well as the factors, which affect PHAs commercialization.

  1. 47 CFR 74.787 - Digital licensing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Digital licensing. 74.787 Section 74.787... Booster Stations § 74.787 Digital licensing. (a) Applications for digital low power television and... CFR 73.3572(a)(4)(ii). The service area of the replacement translator shall be limited to only...

  2. 76 FR 32866 - Cable Landing Licenses; Correction

    Science.gov (United States)

    2011-06-07

    ... Systems Agency in the regulations that we published in the Federal Register of January 14, 2002, 67 FR... COMMISSION 47 CFR Part 1 Cable Landing Licenses; Correction AGENCY: Federal Communications Commission. ACTION... streamlined processing of cable landing license applications. Need for Correction As published, the...

  3. RNA triplexes: from structural principles to biological and biotech applications.

    Science.gov (United States)

    Devi, Gitali; Zhou, Yuan; Zhong, Zhensheng; Toh, Desiree-Faye Kaixin; Chen, Gang

    2015-01-01

    The diverse biological functions of RNA are determined by the complex structures of RNA stabilized by both secondary and tertiary interactions. An RNA triplex is an important tertiary structure motif that is found in many pseudoknots and other structured RNAs. A triplex structure usually forms through tertiary interactions in the major or minor groove of a Watson-Crick base-paired stem. A major-groove RNA triplex structure is stable in isolation by forming consecutive major-groove base triples such as U·A-U and C(+) ·G-C. Minor-groove RNA triplexes, e.g., A-minor motif triplexes, are found in almost all large structured RNAs. As double-stranded RNA stem regions are often involved in biologically important tertiary triplex structure formation and protein binding, the ability to sequence specifically target any desired RNA duplexes by triplex formation would have great potential for biomedical applications. Programmable chemically modified triplex-forming oligonucleotides (TFOs) and triplex-forming peptide nucleic acids (PNAs) have been developed to form TFO·RNA2 and PNA·RNA2 triplexes, respectively, with enhanced binding affinity and sequence specificity at physiological conditions. Here, we (1) provide an overview of naturally occurring RNA triplexes, (2) summarize the experimental methods for studying triplexes, and (3) review the development of TFOs and triplex-forming PNAs for targeting an HIV-1 ribosomal frameshift-inducing RNA, a bacterial ribosomal A-site RNA, and a human microRNA hairpin precursor, and for inhibiting the RNA-protein interactions involving human RNA-dependent protein kinase and HIV-1 viral protein Rev. PMID:25146348

  4. 9 CFR 102.1 - Licenses issued by the Administrator.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL PRODUCTS § 102.1 Licenses issued by the Administrator. Each establishment qualified to prepare biological products under the Virus-Serum-Toxin Act shall hold an unexpired and unrevoked U.S....

  5. Dielectric relaxation in biological systems physical principles, methods, and applications

    CERN Document Server

    Feldman, Yuri

    2015-01-01

    This title covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems.

  6. Application of fish biology in management of the fisheries

    OpenAIRE

    Mbabazi, D.; Namulemo, G.

    2001-01-01

    All biological aspects of the stock are of scientific interest. Specific biological parameters are used either in estimating; yield, or providing a basis for suggesting fisheries management strategies, growth, mortality and stock size are the main determinants of yield, and aspects such as the timing of spawning and recruitment are important in considering management measures. In fisheries science, fish biology contributes in two broad areas; a) Basic biology and distribution of resourc...

  7. Laser heating of dielectric particles for medical and biological applications.

    Science.gov (United States)

    Tribelsky, Michael I; Fukumoto, Yasuhide

    2016-07-01

    We consider the general problem of laser pulse heating of a spherical dielectric particle embedded in a liquid. The discussed range of the problem parameters is typical for medical and biological applications. We focus on the case, when the heat diffusivity in the particle is of the same order of magnitude as that in the fluid. We perform quantitative analysis of the heat transfer equation based on interplay of four characteristic scales of the problem, namely the particle radius, the characteristic depth of light absorption in the material of the particle and the two heat diffusion lengths: in the particle and in the embedding liquid. A new quantitative characteristic of the laser action, that is the cooling time, describing the temporal scale of the cooling down of the particle after the laser pulse is over, is introduced and discussed. Simple analytical formulas for the temperature rise in the center of the particle and at its surface as well as for the cooling time are obtained. We show that at the appropriate choice of the problem parameters the cooling time may be by many orders of magnitude larger the laser pulse duration. It makes possible to minimize the undesirable damage of healthy tissues owing to the finite size of the laser beam and scattering of the laser radiation, simultaneously keeping the total hyperthermia period large enough to kill the pathogenic cells. An example of application of the developed approach to optimization of the therapeutic effect at the laser heating of particles for cancer therapy is presented. PMID:27446706

  8. Application of biological dural graft made by meninges from porkers

    Institute of Scientific and Technical Information of China (English)

    Peng Liu; Shengping Huang; Songtao Qi

    2007-01-01

    BACKGROUND: Presently, over 40 kinds of dural grafts have been successively used in clinic. Among them, lyophilized human dura mater with good histocompatibility and less complications is applied most widely. But there are a few reports on cases of infected spongiform encephalopathy following application of lyodura. More ideal repair materials deserve to be further investigated.OBJECTIVE: To investigate the efficiency and safety of biological dural graft made by meninges from porkers to repair meningeal injury.DESIGN: A self-control observation.SETTING: Wuhan General Hospital of Guangzhou Military Area Command of Chinese PLA.MATERIALS: Sixteen New Zealand Rabbits, of either gender, weighing from 2 to 3 kg, of clean grade Ⅱ,with the age of 0.5 - 1 year, were involved in this experiment. The involved rabbits were provided by the Animal Experimental Center of the First Military Medical University of Chinese PLA. Biological surgical patch (dural graft) was developed by Guangdong Guanhao Biotechnological Co.,Ltd. It was processed by using meninges from porkers by tissue engineering technology.METHODS: This experiment was carried out in the Experimental Center of the 157 Hospital of Chinese PLA between December 2003 and June 2004. ① The experimental rabbits were anesthetized. Dura mater was exposed from two sides ofpostmedial line of coronal suture. A rectangular dura mater about 8 mm × 8mm in size was cut off. Then a biological surgical patch (dural graft) was sheared into insert with 8 mm diameter and sutured. The left dura mater was untouched and used as control. Scalp was sutured, and postoperative wound healing and recovery were observed. ②The anesthetized rabbits were sacrificed at postoperative 3, 14, 30 and 90 days, 4 rabbits once. The whole head was cut off, and its scalp was removed.Afterwards, the head was fixed by formalin. Tissues in operative site were obtained, performed routine paraffin embedding, sliced and conducted HE staining, finally, the

  9. Development and application of biological technologies in fish genetic breeding.

    Science.gov (United States)

    Xu, Kang; Duan, Wei; Xiao, Jun; Tao, Min; Zhang, Chun; Liu, Yun; Liu, ShaoJun

    2015-02-01

    Fish genetic breeding is a process that remolds heritable traits to obtain neotype and improved varieties. For the purpose of genetic improvement, researchers can select for desirable genetic traits, integrate a suite of traits from different donors, or alter the innate genetic traits of a species. These improved varieties have, in many cases, facilitated the development of the aquaculture industry by lowering costs and increasing both quality and yield. In this review, we present the pertinent literatures and summarize the biological bases and application of selection breeding technologies (containing traditional selective breeding, molecular marker-assisted breeding, genome-wide selective breeding and breeding by controlling single-sex groups), integration breeding technologies (containing cross breeding, nuclear transplantation, germline stem cells and germ cells transplantation, artificial gynogenesis, artificial androgenesis and polyploid breeding) and modification breeding technologies (represented by transgenic breeding) in fish genetic breeding. Additionally, we discuss the progress our laboratory has made in the field of chromosomal ploidy breeding of fish, including distant hybridization, gynogenesis, and androgenesis. Finally, we systematically summarize the research status and known problems associated with each technology.

  10. The new biology of cancer: future clinical applications.

    Science.gov (United States)

    Yarbro, J W

    1989-06-01

    Our recognition that cancer evolves by clonal selection and that the basis for this selection is the growth advantage provided by the inappropriate expression or suppression of genes present in all normal cells allows us to anticipate that the pathways of this evolutionary process may be discovered. If a finite number of such pathways exist with some commonality between various tumors, there is the possibility to anticipate the mechanisms that cell clones might use for both carcinogenesis and tumor progression and to deal with evolving clones before their survival potential becomes overwhelming. As our biochemical understanding increases we may develop the capability to do the following: to identify individuals who have inherited or acquired defective cancer suppressor genes; to identify precursor lesions more exactly; to characterize the degree of progression of a newly diagnosed tumor (has the metastatic phenotype evolved?); to develop antibodies against cell membrane proteins necessary to tumor progression; to produce immune probes that carry cytotoxins or isotopes to specific cell populations; and to take advantage of cell signals to modify tumor growth. The potential for application of the New Biology to cancer medicine seems endless.

  11. Natural analog studies: Licensing perspective

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.W. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This report describes the licensing perspective of the term {open_quotes}natural analog studies{close_quotes} as used in CFR Part 60. It describes the misunderstandings related to its definition which has become evident during discussions at the U.S Nuclear Regulatory Commission meetings and tries to clarify the appropriate applications of natural analog studies to aspects of repository site characterization.

  12. 10 CFR 51.60 - Environmental report-materials licenses.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-materials licenses. 51.60 Section 51... Section 102(2) Environmental Reports-Materials Licenses § 51.60 Environmental report—materials licenses..., a separate document, entitled “Applicant's Environmental Report” or “Supplement to...

  13. 47 CFR 80.51 - Ship earth station licensing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Ship earth station licensing. 80.51 Section 80.51 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.51 Ship earth station licensing. A...

  14. 50 CFR 665.3 - Licensing and registration.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Licensing and registration. 665.3 Section... ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC General § 665.3 Licensing and... licensing and registration requirements in the exact manner required by applicable state law or regulation....

  15. Establishment of licensing process for development reactors

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Jong Chull; Yune, Young Gill; Kim, Woong Sik (and others)

    2006-02-15

    A study on licensing processes for development reactors has been performed to prepare the licensing of development reactors developed in Korea. The contents and results of the study are summarized as follows. The licensing processes for nuclear reactors in Korea, U.S.A., Japan, France, U.K., Canada, and IAEA were surveyed and analyzed to obtain technical bases necessary for establishing licensing processes applicable to development reactors in Korea. Based on the technical bases obtained the above analysis, the purpose, power output, and design characteristics of development reactors were analyzed in detail. The analysis results suggested that development reactors should be classified as a new reactor category (called as 'development reactor') separated from the current reactor categories such as the research reactor and the power reactor. Therefore, it is proposed to establish a new reactor category classified as 'development reactor' for the development reactors. And licensing processes, including licensing technical requirements, licensing document requirements, and other regulatory requirements, were also proposed for the development reactors. In order to institutionalize the licensing processes developed in this study, it is necessary to revise the current laws. Therefore, draft provisions of Atomic Energy Act, Enforcement Decree of the Atomic Energy Act, and Enforcement Regulation of the Atomic Energy Act have been developed for the preparation of the future legalization of the licensing processes proposed for the development reactors. Conclusively, a proposal of licensing processes and draft provisions of laws have been developed for the development reactors. The results proposed in this study can be applied directly to the licensing of the future development reactors. Furthermore, they will also contribute to establishing successfully the licensing processes of the development reactors.

  16. A review on biological adaptation: with applications in engineering science

    Directory of Open Access Journals (Sweden)

    LiMin Luo

    2014-06-01

    Full Text Available Biological adaptation refers to that organisms change themselves at morphological, physiological, behavioral and molecular level to better survive in a changing environment. It includes phenotype adaptation and molecular adaptation. Biological adaptation is a driving force of evolution. Biological adaptation was described from Darwinian theory of evolution to the theory of molecular evolution in present paper. Adaptive control and adaptive filtering were briefly described also.

  17. Global optimization in systems biology: stochastic methods and their applications

    OpenAIRE

    Balsa-Canto, Eva; Banga, Julio R.; Egea, José A.; Villaverde, A. F.; Hijas-Liste, G. M.

    2012-01-01

    Mathematical optimization is at the core of many problems in systems biology: (1) as the underlying hypothesis for model development, (2) in model identification, or (3) in the computation of optimal stimulation procedures to synthetically achieve a desired biological behavior. These problems are usually formulated as nonlinear programing problems (NLPs) with dynamic and algebraic constraints. However the nonlinear and highly constrained nature of systems biology models, together with the usu...

  18. NRC licensing requirements: DOD options

    Energy Technology Data Exchange (ETDEWEB)

    Pike, W.J.; O' Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  19. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90Sr or 238Pu; radioisotopic dynamic electric generators with 90Sr or 238Pu; and applications of radioisotopes for luminous sources (lights) with 3H, 85Kr, or 147Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  20. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  1. Biological effects of neutrons, mechanisms and applications; Effets biologiques des neutrons: mecanismes et applications

    Energy Technology Data Exchange (ETDEWEB)

    Voisin, Ph. [CEA/Fontenay-aux-Roses, Inst. de Protection et de Surete Nucleaire (IPSN), 92 (France)

    1999-12-01

    The interest to study the ionizing radiations effects on the biological structures concern not only the fundamental comprehension of the mechanisms leading to the radiation damage but also much more pragmatic problems such as the accidental overexposure or radiotherapy treatment. Among these fundamental or applied studies, the neutrons effects take an important part, because of their particular mode of indirect ionization effect and their applications, as well civil as military ones. The purpose of this review is to point out some specific biological effects of neutrons and to describe biological methods to measure them. It clearly appears that neutrons biological effects are more deleterious than those caused by the radiations of lower TEL(X- and {gamma}-rays) taken as reference, for all the measurement levels used, genes mutations, chromosome aberrations, cellular survival or carcinogenesis. This difference is probably related to the density of the energy deposit in the vital cell targets, and to the absence of significant variations related to oxygenation, dose rate or dose fractionation. Such toxic effects, when considered in the course of a criticality accident, can paradoxically become an advantage in the follow-up of therapeutic treatment. (author)

  2. Nuclear power stations licensing

    International Nuclear Information System (INIS)

    The judicial aspects of nuclear stations licensing are presented. The licensing systems of the United States, Spain, France and Federal Republic of Germany are focused. The decree n0 60.824 from July 7 sup(th), 1967 and the following legislation which define the systematic and area of competence in nuclear stations licensing are analysed

  3. Licensing of Practices

    CERN Document Server

    2001-01-01

    All practices are licensed by Radiation Protection Centre (RPC). RPC verifies if license seeker is prepares to work with sources in an adequate and safe manner. Types of licences defined in the Republic of Lithuania are listed. Data on the number of licensees and of licenses issued in 1999-2001 is presented.

  4. Optical Properties and Biological Applications of Electromagnetically Coupled Metal Nanoparticles

    Science.gov (United States)

    Sheikholeslami, Sassan Nathan

    The optical properties of metallic particles change dramatically as the size shrinks to the nanoscale. The familiar mirror-like sheen of bulk metals is replaced by the bright, sharp, colorful plasmonic resonances of nanoparticles. The resonances of plasmonic metal nanoparticles are highly tunable throughout the visible spectrum, depending on the size, shape, local dielectric environment, and proximity to other optical resonances. Fundamental and applied research in the nanoscience community in the past few decades has sought to understand and exploit these phenomena for biological applications. In this work, discrete nanoparticle assemblies were produced through biomolecular interactions and studied at the single particle level with darkfield spectroscopy. Pairs of gold nanoparticles tethered by DNA were utilized as molecular rulers to study the dynamics of DNA bending by the restriction enzyme EcoRV. These results substantiated that nanoparticle rulers, deemed "plasmon rulers", could measure the dynamics of single biomolecules with high throughput, long lifetime, and high temporal resolution. To extend these concepts for live cell studies, a plasmon ruler comprised of peptide-linked gold nanoparticle satellites around a core particle was synthesized and utilized to optically follow cell signaling pathways in vivo at the single molecule level. The signal provided by these plasmon rulers allowed continuous observation of caspase-3 activation at the single molecule level in living cells for over 2 hours, unambiguously identifying early stage activation of caspase-3 in apoptotic cells. In the last section of this dissertation, an experimental and theoretical study of electomagnetic coupling in asymmetric metal nanoparticle dimers is presented. A "heterodimer" composed of a silver particle and a gold particle is observed to have a novel coupling between a plasmon mode (free electron oscillations) and an inter-band absorption process (bound electron transitions). The

  5. Technical Challenges in the Application and Licensing of Digital Instrumentation and Control Systems in Nuclear Power Plants

    International Nuclear Information System (INIS)

    With the modernization of existing analogue instrumentation and control (I&C) systems in nuclear power plants through digital I&C technology, and the implementation of digital I&C systems in new plants, the industry is faced with significant challenges. These challenges appear in the form of difficulties in managing the necessarily incremental transition, highly integrated (and interdependent) architectures, the flexible configurability enabled by digital technology, and uncertainty and inconsistency in licensing digital I&C systems and equipment in the different Member States. This publication discusses 17 major issues that utilities, developers, suppliers and regulatory stakeholders need to consider, so that the industry can capture and benefit from shared experience, recent technological developments, and emerging best practices

  6. Molecular biology techniques and applications for ocean sensing

    Directory of Open Access Journals (Sweden)

    J. P. Zehr

    2008-11-01

    Full Text Available The study of marine microorganisms using molecular biological techniques is now widespread in the ocean sciences. These techniques target nucleic acids which record the evolutionary history of microbes, and encode for processes which are active in the ocean today. Here we review some of the most commonly used molecular biological techniques. Molecular biological techniques permit study of the abundance, distribution, diversity, and physiology of microorganisms in situ. These techniques include the polymerase chain reaction (PCR and reverse-transcriptase PCR, quantitative PCR, whole assemblage "fingerprinting" approaches (based on nucleic acid sequence or length heterogeneity, oligonucleotide microarrays, and high-throughput shotgun sequencing of whole genomes and gene transcripts, which can be used to answer biological, ecological, evolutionary and biogeochemical questions in the ocean sciences. Moreover, molecular biological approaches may be deployed on ocean sensor platforms and hold promise for tracking of organisms or processes of interest in near-real time.

  7. Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology

    OpenAIRE

    Hill Steven M; Neve Richard M; Bayani Nora; Kuo Wen-Lin; Ziyad Safiyyah; Spellman Paul T; Gray Joe W; Mukherjee Sach

    2012-01-01

    Abstract Background An important question in the analysis of biochemical data is that of identifying subsets of molecular variables that may jointly influence a biological response. Statistical variable selection methods have been widely used for this purpose. In many settings, it may be important to incorporate ancillary biological information concerning the variables of interest. Pathway and network maps are one example of a source of such information. However, although ancillary informatio...

  8. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  9. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff`s review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission`s regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements.

  10. Standard review plan for the review of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the nuclear power industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  11. 9th International Conference on Practical Applications of Computational Biology and Bioinformatics

    CERN Document Server

    Rocha, Miguel; Fdez-Riverola, Florentino; Paz, Juan

    2015-01-01

    This proceedings presents recent practical applications of Computational Biology and  Bioinformatics. It contains the proceedings of the 9th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, at June 3rd-5th, 2015. The International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB) is an annual international meeting dedicated to emerging and challenging applied research in Bioinformatics and Computational Biology. Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis o...

  12. IRIS Licensing Status

    Energy Technology Data Exchange (ETDEWEB)

    Kling, Charles L.; Carelli, Mario D. [Westinghouse Electric Company, Windsor (United States)

    2006-04-15

    The International Reactor Innovative and Secure (IRIS) nuclear power plant is well into the pre-application review process with the US NRC and has accomplished its first near term goal of obtaining US NRC feedback on the long term testing program. To date, the IRIS team has submitted to the US NRC a number of documents patterned after the Evaluation Model Development and Assessment Process (EMDAP) outlined in Regulatory Guide 1,203. They have covered a detailed description of IRIS, initial safety analysis results, PIRT development for limiting transients, scaling analysis and a description of the test program. The IRIS Safety-by-Desing{sup TM} intrinsically eliminates and/or significantly reduces the consequences of traditional LWR accidents. In addition, the fewer passive safety systems are similar in principle to those of the US NRC approved AP1000 design. For these reasons, the IRIS testing program only needs to include those features unique to the IRIS design. NRC feedback was that the planned test program appeared to be complete and could generate sufficient information to support a Design Certification (DC) submittal. The US NRC has also stated that a DC application must include complete information regarding the test program. On this basis the IRIS team has initiated an aggressive program to conduct IRIS testing to support a DC submittal by the end of 2008. Subsequent US NRC review should be expeditious because of the AP1000 precedent, allowing IRIS to obtain its Final Design Approval (FDA) in 2012; thereby, maintaining its goal of deployment in the 2015-2017 time frame. The next steps in the pre-application review process will be to provide the US NRC with a road map of the anticipated IRIS licensing process, a review of current licensing requirements showing that IRIS meets or exceeds all current criteria and information to support the long term goal of redefining the Emergency Planning Zone (EPZ)

  13. NMR-based Metabolomics Applications in Biological and Environmental Science

    Science.gov (United States)

    As a complimentary tool to other omics platforms, metabolomics is increasingly being used bybiologists to study the dynamic response of biological systems (cells, tissues, or wholeorganisms) under diverse physiological or pathological conditions. Metabolomics deals with the quali...

  14. Scalable pattern recognition algorithms applications in computational biology and bioinformatics

    CERN Document Server

    Maji, Pradipta

    2014-01-01

    Reviews the development of scalable pattern recognition algorithms for computational biology and bioinformatics Includes numerous examples and experimental results to support the theoretical concepts described Concludes each chapter with directions for future research and a comprehensive bibliography

  15. Molecular biology techniques and applications for ocean sensing

    Directory of Open Access Journals (Sweden)

    J. P. Zehr

    2009-05-01

    Full Text Available The study of marine microorganisms using molecular biological techniques is now widespread in the ocean sciences. These techniques target nucleic acids which record the evolutionary history of microbes, and encode for processes which are active in the ocean today. Molecular techniques can form the basis of remote instrumentation sensing technologies for marine microbial diversity and ecological function. Here we review some of the most commonly used molecular biological techniques. These techniques include the polymerase chain reaction (PCR and reverse-transcriptase PCR, quantitative PCR, whole assemblage "fingerprinting" approaches (based on nucleic acid sequence or length heterogeneity, oligonucleotide microarrays, and high-throughput shotgun sequencing of whole genomes and gene transcripts, which can be used to answer biological, ecological, evolutionary and biogeochemical questions in the ocean sciences. Moreover, molecular biological approaches may be deployed on ocean sensor platforms and hold promise for tracking of organisms or processes of interest in near-real time.

  16. Thiosemicarbazones: preparation methods, synthetic applications and biological importance

    International Nuclear Information System (INIS)

    Thiosemicarbazones are a class of compounds known by their chemical and biological properties, such as antitumor, antibacterial, antiviral and antiprotozoal activity. Their ability to form chelates with metals has great importance in their biological activities. Their synthesis is very simple, versatile and clean, usually giving high yields. They are largely employed as intermediates, in the synthesis of others compounds. This article is a survey of some of these characteristics showing their great importance to organic and medicinal chemistry. (author)

  17. Isothermal Calorimetry for Biological Applications in Food Science and Technology

    OpenAIRE

    Wadsö, Lars; Gomez, Federico

    2009-01-01

    All physical, chemical and biological processes produce heat and isothermal calorimetry is a general measurement technique to study all kinds of processes by the heat they produce. This paper gives several examples of studies of biological processes in the food area using isothermal calorimetry. It is for example shown how different unit operations influence respiration of vegetable tissue, how the kinetics of a fermentation process can be studied, and how spoilage processes can be followed f...

  18. Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

    OpenAIRE

    Ye-Rang Yun; Jong Eun Won; Eunyi Jeon; Sujin Lee; Wonmo Kang; Hyejin Jo; Jun-Hyeog Jang; Ueon Sang Shin; Hae-Won Kim

    2010-01-01

    Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain opt...

  19. Sparse combinatorial inference with an application in cancer biology

    OpenAIRE

    Mukherjee, Sach; Pelech, Steven; Neve, Richard M.; Kuo, Wen-Lin; Ziyad, Safiyyah; Spellman, Paul T.; Joe W Gray; Speed, Terence P.

    2008-01-01

    Motivation: Combinatorial effects, in which several variables jointly influence an output or response, play an important role in biological systems. In many settings, Boolean functions provide a natural way to describe such influences. However, biochemical data using which we may wish to characterize such influences are usually subject to much variability. Furthermore, in high-throughput biological settings Boolean relationships of interest are very often sparse, in the sense of being embedde...

  20. Application of E-infinity theory to biology

    International Nuclear Information System (INIS)

    Albert Einstein combined continuous space and time into his special relativity, El-Naschie discovered the transfinite discontinuity of space-time in his E-infinity theory where infinity of dimensions was created. We find a partner of both space-time and E-infinity in biology. In our theory, the number of cells in an organism endows an additional dimension in biology, leading to explanation of many complex phenomena

  1. 78 FR 15929 - Notice of Intent To Grant Exclusive License

    Science.gov (United States)

    2013-03-13

    ..., Agricultural Research Service, intends to grant to Lysando AG of Triesenberg, Liechtenstein, an exclusive..., Liechtenstein has submitted a complete and sufficient application for a license. The prospective...

  2. 10 CFR 50.50 - Issuance of licenses and construction permits.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Issuance of licenses and construction permits. 50.50... FACILITIES Issuance, Limitations, and Conditions of Licenses and Construction Permits § 50.50 Issuance of licenses and construction permits. Upon determination that an application for a license meets the...

  3. Image Processing Technology in the Motor Vehicle License Plate Recognition Technology Application%图像处理技术在机动车车牌自动识别技术中的应用

    Institute of Scientific and Technical Information of China (English)

    宁彬

    2013-01-01

    主要分析了图像处理技术在机动车车牌自动识别技术中的应用.按照车牌定位由彩色图转化到灰度图、车牌区域分割、车牌位置校正等步骤,对车牌字符的识别进行了分析,并对自动识别技术进行了改进.基于图像处理技术设计的机动车辆车牌自动识别系统,在保障交通顺畅运行方面发挥着巨大作用.从实际应用效果看图像处理技术在机动车车牌自动识别技术实际运用中效果良好,具有一定的推广价值.%The application of image processing technology in the motor vehicle license plate automatic identification technology was analyzed. In accordance with the license plate location transformed by the color chart to grayscale, license plate region segmentation, the license plate position correction step on the license plate character recognition, and automatic identification technology improvements. Motor vehicle car brand automatic identification system design based on the image processing technology, play a huge role in the protection of traffic running smoothly. From the effect of practical application of image processing technology in the motor vehicle license plate automatic identification technology to practical use in the good results, the promotional value.

  4. Synthetic Biology and Human Health: Potential Applications for Spaceflight

    Science.gov (United States)

    Karouia, Fathi; Carr, Christopher; Cai, Yizhi; Chen, Y.; Grenon, Marlene; Larios-Sanz, Maia; Jones, Jeffrey A.; Santos, Orlando

    2011-01-01

    Human space travelers experience a unique environment that affects homeostasis and physiologic adaptation. Spaceflight-related changes have been reported in the musculo-skeletal, cardiovascular, neurovestibular, endocrine, and immune systems. The spacecraft environment further subjects the traveler to noise and gravitational forces, as well as airborne chemical, microbiological contaminants, and radiation exposure. As humans prepare for longer duration missions effective countermeasures must be developed, verified, and implemented to ensure mission success. Over the past ten years, synthetic biology has opened new avenues for research and development in areas such as biological control, biomaterials, sustainable energy production, bioremediation, and biomedical therapies. The latter in particular is of great interest to the implementation of long-duration human spaceflight capabilities. This article discusses the effects of spaceflight on humans, and reviews current capabilities and potential needs associated with the health of the astronauts where synthetic biology could play an important role in the pursuit of space exploration.

  5. Biological Membrane Ion Channels Dynamics, Structure, and Applications

    CERN Document Server

    Chung, Shin-Ho; Krishnamurthy, Vikram

    2007-01-01

    Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the area of ion channel investigations

  6. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  7. Geospatial Technology Applications and Infrastructure in the Biological Resources Division

    Science.gov (United States)

    D'Erchia, Frank; Getter, James; D'Erchia, Terry D.; Root, Ralph; Stitt, Susan; White, Barbara

    1998-01-01

    Executive Summary -- Automated spatial processing technology such as geographic information systems (GIS), telemetry, and satellite-based remote sensing are some of the more recent developments in the long history of geographic inquiry. For millennia, humankind has endeavored to map the Earth's surface and identify spatial relationships. But the precision with which we can locate geographic features has increased exponentially with satellite positioning systems. Remote sensing, GIS, thematic mapping, telemetry, and satellite positioning systems such as the Global Positioning System (GPS) are tools that greatly enhance the quality and rapidity of analysis of biological resources. These technologies allow researchers, planners, and managers to more quickly and accurately determine appropriate strategies and actions. Researchers and managers can view information from new and varying perspectives using GIS and remote sensing, and GPS receivers allow the researcher or manager to identify the exact location of interest. These geospatial technologies support the mission of the U.S. Geological Survey (USGS) Biological Resources Division (BRD) and the Strategic Science Plan (BRD 1996) by providing a cost-effective and efficient method for collection, analysis, and display of information. The BRD mission is 'to work with others to provide the scientific understanding and technologies needed to support the sound management and conservation of our Nation's biological resources.' A major responsibility of the BRD is to develop and employ advanced technologies needed to synthesize, analyze, and disseminate biological and ecological information. As the Strategic Science Plan (BRD 1996) states, 'fulfilling this mission depends on effectively balancing the immediate need for information to guide management of biological resources with the need for technical assistance and long-range, strategic information to understand and predict emerging patterns and trends in ecological systems

  8. Some Applications of Mathematics for the Biology Classroom

    Science.gov (United States)

    Horton, Robert M.; Leonard, William H.

    2013-01-01

    Biology and mathematics are inextricably linked. In this article, we show a few of the many areas in which this linkage might be made explicit. By doing so, teachers can deepen students' understanding and appreciation of both subjects. In this article, we explore some of these areas, providing brief explanations of the mathematics and some of the…

  9. DNA Synthesis, Assembly and Applications in Synthetic Biology

    OpenAIRE

    Ma, Siying; Tang, Nicholas; Tian, Jingdong

    2012-01-01

    The past couple of years saw exciting new developments in microchip-based gene synthesis technologies. Such technologies hold the potential for significantly increasing the throughput and decreasing the cost of gene synthesis. Together with more efficient enzymatic error correction and genome assembly methods, these new technologies are pushing the field of synthetic biology to a higher level.

  10. Click chemistry mediated functionalization of vertical nanowires for biological applications

    DEFF Research Database (Denmark)

    Vutti, Surendra; Schoffelen, Sanne; Bolinsson, Jessica;

    2016-01-01

    is of general interest for biological studies. The attachment of a peptide substrate provided NW arrays for the detection of protease activity. In addition, green fluorescent protein was immobilized in a site-specific manner and recognized by antibody binding to demonstrate the proof-of-concept for the use...

  11. 75 FR 39667 - Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent Application

    Science.gov (United States)

    2010-07-12

    ... for preparing multivalent vaccines, recombinant DNA expression ] products and more particularly to..., Dr. Paul Mele, Office of Research and Technology Applications (ORTA), (301) 619- 6664, both...

  12. DNA confinement in nanochannels: physics and biological applications

    DEFF Research Database (Denmark)

    Reisner, Walter; Pedersen, Jonas Nyvold; Austin, Robert H

    2012-01-01

    biological interest in extracting linear sequence information from elongated DNA molecules, from a physics view these systems are fascinating as they enable probing of single-molecule conformation in environments with dimensions that intersect key physical length-scales in the 1 nm to 100μm range. (Some......DNA is the central storage molecule of genetic information in the cell, and reading that information is a central problem in biology. While sequencing technology has made enormous advances over the past decade, there is growing interest in platforms that can readout genetic information directly...... from long single DNA molecules, with the ultimate goal of single-cell, single-genome analysis. Such a capability would obviate the need for ensemble averaging over heterogeneous cellular populations and eliminate uncertainties introduced by cloning and molecular amplification steps (thus enabling...

  13. Neutron scattering applications in structural biology: now and the future

    Energy Technology Data Exchange (ETDEWEB)

    Trewhella, J. [Los Alamos National Lab., NM (United States)

    1996-05-01

    Neutrons have an important role to play in structural biology. Neutron crystallography, small-angle neutron scattering and inelastic neutron scattering techniques all contribute unique information on biomolecular structures. In particular, solution scattering techniques give critical information on the conformations and dispositions of the components of complex assemblies under a wide variety of relevant conditions. The power of these methods is demonstrated here by studies of protein/DNA complexes, and Ca{sup 2+}-binding proteins complexed with their regulatory targets. In addition, we demonstrate the utility of a new structural approach using neutron resonance scattering. The impact of biological neutron scattering to date has been constrained principally by the available fluxes at neutron sources and the true potential of these approaches will only be realized with the development of new more powerful neutron sources. (author)

  14. Applications of membrane computing in systems and synthetic biology

    CERN Document Server

    Gheorghe, Marian; Pérez-Jiménez, Mario

    2014-01-01

    Membrane Computing was introduced as a computational paradigm in Natural Computing. The models introduced, called Membrane (or P) Systems, provide a coherent platform to describe and study living cells as computational systems. Membrane Systems have been investigated for their computational aspects and employed to model problems in other fields, like: Computer Science, Linguistics, Biology, Economy, Computer Graphics, Robotics, etc. Their inherent parallelism, heterogeneity and intrinsic versatility allow them to model a broad range of processes and phenomena, being also an efficient means to solve and analyze problems in a novel way. Membrane Computing has been used to model biological systems, becoming with time a thorough modeling paradigm comparable, in its modeling and predicting capabilities, to more established models in this area. This book is the result of the need to collect, in an organic way, different facets of this paradigm. The chapters of this book, together with the web pages accompanying th...

  15. 75 FR 6193 - Union Electric Company dba Ameren/UE; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2010-02-08

    ... Energy Regulatory Commission Union Electric Company dba Ameren/UE; Notice of Application for Amendment of... Filed: November 6, 2009. Supplemented on January 13, 2010. d. Applicant: Union Electric Company dba... manage and maintain the lease area for public access, and would rehabilitate an existing building for...

  16. 75 FR 54116 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-09-03

    ... application and starter ground cover) and applications in the fields of soil and slope stabilization, enhanced bioremediation, dust and run-off control, fly ash removal, emissions particulate removal, metal and inorganic chelation in soils and water, soil erosion, road stabilizer, and dust suppression. DATES: Written...

  17. 77 FR 37035 - Goose River Hydro, Inc.; Independence Hydro, LLC; Notice of Application for Transfer of License...

    Science.gov (United States)

    2012-06-20

    ... Energy Regulatory Commission Goose River Hydro, Inc.; Independence Hydro, LLC; Notice of Application for..., Inc. (transferor) and Independence Hydro, LLC (transferee) filed an application for the transfer of..., Independence Hydro, LLC, 220 Maine Mall Road, South Portland, ME 01406, (207) 274-0001. FERC Contact:...

  18. 77 FR 27759 - City of Crystal Falls, MI; Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2012-05-11

    ... Energy Regulatory Commission City of Crystal Falls, MI; Notice of Application for Temporary Variance of.... Applicant: City of Crystal Falls, MI. e. Name of Project: Crystal Falls Project. f. Location: The project is located on the Paint River in the City of Crystal Falls, Michigan. g. Filed Pursuant to: Federal Power...

  19. 78 FR 21923 - City of Crystal Falls, MI; Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-04-12

    ... Energy Regulatory Commission City of Crystal Falls, MI; Notice of Application for Temporary Variance of.... Applicant: City of Crystal Falls, MI. e. Name of Project: Crystal Falls Project. f. Location: The project is located on the Paint River in the City of Crystal Falls, Iron County, Michigan. g. Filed Pursuant...

  20. Fish gelatin thin film standards for biological application of PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Manuel, Jack E., E-mail: jaelma@gmail.com [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States); Rout, Bibhudutta; Szilasi, Szabolcs Z.; Bohara, Gyanendra [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States); Deaton, James; Luyombya, Henry [Louisiana Accelerator Center, University of Louisiana at Lafayette, Lafayette, LA 70503 (United States); Briski, Karen P. [Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA 71209 (United States); Glass, Gary A. [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States)

    2014-08-01

    There exists a critical need to understand the flow and accumulation of metallic ions, both naturally occurring and those introduced to biological systems. In this paper the results of fabricating thin film elemental biological standards containing nearly any combination of trace elements in a protein matrix are presented. Because it is capable of high elemental sensitivity, particle induced X-ray emission spectrometry (PIXE) is an excellent candidate for in situ analysis of biological tissues. Additionally, the utilization of microbeam PIXE allows the determination of elemental concentrations in and around biological cells. However, obtaining elemental reference standards with the same matrix constituents as brain tissue is difficult. An excellent choice for simulating brain-like tissue is Norland® photoengraving glue which is derived from fish skin. Fish glue is water soluble, liquid at room temperature, and resistant to dilute acid. It can also be formed into a thin membrane which dries into a durable, self-supporting film. Elements of interest are introduced to the fish glue in precise volumetric additions of well quantified atomic absorption standard solutions. In this study GeoPIXE analysis package is used to quantify elements intrinsic to the fish glue as well as trace amounts of manganese added to the sample. Elastic (non-Rutherford) backscattered spectroscopy (EBS) and the 1.734 MeV proton-on-carbon {sup 12}C(p,p){sup 12}C resonance is used for a normalization scheme of the PIXE spectra to account for any discrepancies in X-ray production arising from thickness variation of the prepared standards. It is demonstrated that greater additions of the atomic absorption standard cause a viscosity reduction of the liquid fish glue resulting in thinner films but the film thickness can be monitored by using simultaneous PIXE and EBS proton data acquisition.

  1. Biclustering Methods: Biological Relevance and Application in Gene Expression Analysis

    OpenAIRE

    Ali Oghabian; Sami Kilpinen; Sampsa Hautaniemi; Elena Czeizler

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expressi...

  2. Application of Mitochondrial DNA Polymorphism to Meloidogyne Molecular Population Biology

    OpenAIRE

    Hyman, B. C.; Whipple, L.E.

    1996-01-01

    Recent advances in molecular biology have enabled the genotyping of individual nematodes, facilitating the analysis of genetic variability within and among plant-pathogenic nematode isolates. This review first describes representative examples of how RFLP, RAPD, AFLP, and DNA sequence analysis have been employed to describe populations of several phytonematodes, including the pinewood, burrowing, root-knot, and cyst nematodes. The second portion of this paper evaluates the utility of a size-v...

  3. Application of scanning electrochemical microscopy to biological samples

    OpenAIRE

    Lee, C.(Institute of Physics, Academia Sinica, Taipei, Taiwan); Kwak, J.; Bard, A J

    1990-01-01

    The scanning electrochemical microscope can be used in the feedback mode in two-dimensional scans over biological substrates to obtain topographic information at the micrometer level. In this mode, the effect of distance between a substrate (either conductive or insulating) and a scanning ultramicroelectrode tip on the electrolytic current flowing at the tip is recorded as a function of the tip x-y position. Scans of the upper surface of a grass leaf and the lower surface of a Ligustrum sinen...

  4. Fish gelatin thin film standards for biological application of PIXE

    Science.gov (United States)

    Manuel, Jack E.; Rout, Bibhudutta; Szilasi, Szabolcs Z.; Bohara, Gyanendra; Deaton, James; Luyombya, Henry; Briski, Karen P.; Glass, Gary A.

    2014-08-01

    There exists a critical need to understand the flow and accumulation of metallic ions, both naturally occurring and those introduced to biological systems. In this paper the results of fabricating thin film elemental biological standards containing nearly any combination of trace elements in a protein matrix are presented. Because it is capable of high elemental sensitivity, particle induced X-ray emission spectrometry (PIXE) is an excellent candidate for in situ analysis of biological tissues. Additionally, the utilization of microbeam PIXE allows the determination of elemental concentrations in and around biological cells. However, obtaining elemental reference standards with the same matrix constituents as brain tissue is difficult. An excellent choice for simulating brain-like tissue is Norland® photoengraving glue which is derived from fish skin. Fish glue is water soluble, liquid at room temperature, and resistant to dilute acid. It can also be formed into a thin membrane which dries into a durable, self-supporting film. Elements of interest are introduced to the fish glue in precise volumetric additions of well quantified atomic absorption standard solutions. In this study GeoPIXE analysis package is used to quantify elements intrinsic to the fish glue as well as trace amounts of manganese added to the sample. Elastic (non-Rutherford) backscattered spectroscopy (EBS) and the 1.734 MeV proton-on-carbon 12C(p,p)12C resonance is used for a normalization scheme of the PIXE spectra to account for any discrepancies in X-ray production arising from thickness variation of the prepared standards. It is demonstrated that greater additions of the atomic absorption standard cause a viscosity reduction of the liquid fish glue resulting in thinner films but the film thickness can be monitored by using simultaneous PIXE and EBS proton data acquisition.

  5. Fish gelatin thin film standards for biological application of PIXE

    International Nuclear Information System (INIS)

    There exists a critical need to understand the flow and accumulation of metallic ions, both naturally occurring and those introduced to biological systems. In this paper the results of fabricating thin film elemental biological standards containing nearly any combination of trace elements in a protein matrix are presented. Because it is capable of high elemental sensitivity, particle induced X-ray emission spectrometry (PIXE) is an excellent candidate for in situ analysis of biological tissues. Additionally, the utilization of microbeam PIXE allows the determination of elemental concentrations in and around biological cells. However, obtaining elemental reference standards with the same matrix constituents as brain tissue is difficult. An excellent choice for simulating brain-like tissue is Norland® photoengraving glue which is derived from fish skin. Fish glue is water soluble, liquid at room temperature, and resistant to dilute acid. It can also be formed into a thin membrane which dries into a durable, self-supporting film. Elements of interest are introduced to the fish glue in precise volumetric additions of well quantified atomic absorption standard solutions. In this study GeoPIXE analysis package is used to quantify elements intrinsic to the fish glue as well as trace amounts of manganese added to the sample. Elastic (non-Rutherford) backscattered spectroscopy (EBS) and the 1.734 MeV proton-on-carbon 12C(p,p)12C resonance is used for a normalization scheme of the PIXE spectra to account for any discrepancies in X-ray production arising from thickness variation of the prepared standards. It is demonstrated that greater additions of the atomic absorption standard cause a viscosity reduction of the liquid fish glue resulting in thinner films but the film thickness can be monitored by using simultaneous PIXE and EBS proton data acquisition

  6. Biological Applications of Hybrid Quantum Mechanics/Molecular Mechanics Calculation

    Directory of Open Access Journals (Sweden)

    Jiyoung Kang

    2012-01-01

    Full Text Available Since in most cases biological macromolecular systems including solvent water molecules are remarkably large, the computational costs of performing ab initio calculations for the entire structures are prohibitive. Accordingly, QM calculations that are jointed with MM calculations are crucial to evaluate the long-range electrostatic interactions, which significantly affect the electronic structures of biological macromolecules. A UNIX-shell-based interface program connecting the quantum mechanics (QMs and molecular mechanics (MMs calculation engines, GAMESS and AMBER, was developed in our lab. The system was applied to a metalloenzyme, azurin, and PU.1-DNA complex; thereby, the significance of the environmental effects on the electronic structures of the site of interest was elucidated. Subsequently, hybrid QM/MM molecular dynamics (MD simulation using the calculation system was employed for investigation of mechanisms of hydrolysis (editing reaction in leucyl-tRNA synthetase complexed with the misaminoacylated tRNALeu, and a novel mechanism of the enzymatic reaction was revealed. Thus, our interface program can play a critical role as a powerful tool for state-of-the-art sophisticated hybrid ab initio QM/MM MD simulations of large systems, such as biological macromolecules.

  7. NEXT GENERATION NUCLEAR PLANT LICENSING BASIS EVENT SELECTION WHITE PAPER

    Energy Technology Data Exchange (ETDEWEB)

    Mark Holbrook

    2010-09-01

    The Next Generation Nuclear Plant (NGNP) will be a licensed commercial high temperature gas-cooled reactor (HTGR) plant capable of producing the electricity and high temperature process heat for industrial markets supporting a range of end-user applications. The NGNP Project has adopted the 10 CFR 52 Combined License (COL) application process, as recommended in the Report to Congress, dated August 2008, as the foundation for the NGNP licensing strategy. NRC licensing of the NGNP plant utilizing this process will demonstrate the efficacy of licensing future HTGRs for commercial industrial applications. This white paper is one in a series of submittals that will address key generic issues of the COL priority licensing topics as part of the process for establishing HTGR regulatory requirements.

  8. 50 CFR 260.50 - Suspension or revocation of license of licensed sampler or licensed inspector.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Suspension or revocation of license of... Licensing of Samplers and Inspectors § 260.50 Suspension or revocation of license of licensed sampler or... or evidence that he may wish to offer as to why his license should not be suspended or revoked....

  9. Outline and schedule for the HTGR-SC/C licensing plan

    International Nuclear Information System (INIS)

    The Licensing Plan is based on licensing a HTGR-SC/C lead plant in the near term. The plan also provides reference safety material and a basis (requirements, criteria, etc.) for licensing commercial follow-on plants. The plan is structured in two parts: program management and project management, and covers three sequences of licensing activities: pre-application, construction permit application, and operating licensing application. Major activities and a schedule of events are outlined in these three phases indicating the approach, the objective and the documentation involved. The Licensing Plan will be further developed in detail in FY 1982 as part of a Project Decision Package

  10. 15 CFR Appendix 1 to Part 960 - Filing Instructions and Information To Be Included in the Licensing Application

    Science.gov (United States)

    2010-01-01

    ... authorized to do business. Sec. IILaunch Segment Information Provide the characteristics of the launch... benefit purposes, such as the study of the changing global environment. B. If the applicant is...

  11. 75 FR 32418 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-06-08

    ... publication of this announcement. ADDRESSES: United States Army Engineer Research and Development Center, ATTN... can be used in place of synthetic, petroleum-based polymers for soil amendment applications to...

  12. 75 FR 54115 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-09-03

    ... of this announcement. ADDRESSES: United States Army Engineer Research and Development ] Center, Attn... can be used in place of synthetic, petroleum-based polymers for soil amendment applications to...

  13. 78 FR 4465 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2013-01-22

    ...) 76 FR 81992 (December 29, 2011). 2.0 Request/Action The regulations specified in 10 CFR 50.71(e)(3... the afore- mentioned application's April 15, 2013, submittal of the revised FSAR, therefore,...

  14. 75 FR 19956 - Miller and Miller, Waterpower LLC; Notice of Application for Transfer of License and Soliciting...

    Science.gov (United States)

    2010-04-16

    ... Worthville Dam Project No. 3156, located on the Deep River in Randolph County, North Carolina. Applicants... filed electronically via the Internet. See 18 CFR 385.2001(a)(1)(iii)(2008) and the instructions on...

  15. Potential for widespread application of biological control of stored-product pests

    DEFF Research Database (Denmark)

    Hansen, Lise Stengaard

    2007-01-01

    Biological control of stored product pests has substantial potential in Europe". This is essentially the conclusion of the activities of a European working group funded by the COST system, an intergovernmental networking system. Working group 4 of COST action 842 (2000-2005) focussed on biological...... control of stored-product pests and has considered a number of existing and potential fields for application of biological control. Three situations were identified where biological control would be a valuable component of integrated pest management: (1) Empty room treatment against stored-product mites......, beetles and moths; (2) Preventative treatment of bulk commodities against weevils (Sitophilus spp.) and storage mites; (3) Preventative application of egg-parasitoids against moths in packaged products. Development of methods for biological control and of mass production of natural enemies...

  16. BioInt: an integrative biological object-oriented application framework and interpreter.

    Science.gov (United States)

    Desai, Sanket; Burra, Prasad

    2015-01-01

    BioInt, a biological programming application framework and interpreter, is an attempt to equip the researchers with seamless integration, efficient extraction and effortless analysis of the data from various biological databases and algorithms. Based on the type of biological data, algorithms and related functionalities, a biology-specific framework was developed which has nine modules. The modules are a compilation of numerous reusable BioADTs. This software ecosystem containing more than 450 biological objects underneath the interpreter makes it flexible, integrative and comprehensive. Similar to Python, BioInt eliminates the compilation and linking steps cutting the time significantly. The researcher can write the scripts using available BioADTs (following C++ syntax) and execute them interactively or use as a command line application. It has features that enable automation, extension of the framework with new/external BioADTs/libraries and deployment of complex work flows.

  17. Application of computational systems biology to explore environmental toxicity hazards

    DEFF Research Database (Denmark)

    Audouze, Karine Marie Laure; Grandjean, Philippe

    2011-01-01

    ) to ascertain their possible links to relevant adverse effects.Methods: We extracted chemical-protein association networks for each DDT isomer and its metabolites using ChemProt, a disease chemical biology database that includes both binding and gene expression data, and we explored protein-protein interactions...... diseases were linked to the two DDT isomers. Asthma was uniquely linked with p,p´-DDT, and autism with o,p´-DDT. Several reproductive and neurobehavioral outcomes and cancer types were linked to all three compounds.Conclusions: Computer-based modeling relies on available information. Although differences...

  18. Text mining and its potential applications in systems biology.

    Science.gov (United States)

    Ananiadou, Sophia; Kell, Douglas B; Tsujii, Jun-ichi

    2006-12-01

    With biomedical literature increasing at a rate of several thousand papers per week, it is impossible to keep abreast of all developments; therefore, automated means to manage the information overload are required. Text mining techniques, which involve the processes of information retrieval, information extraction and data mining, provide a means of solving this. By adding meaning to text, these techniques produce a more structured analysis of textual knowledge than simple word searches, and can provide powerful tools for the production and analysis of systems biology models. PMID:17045684

  19. Dynamic light scattering with applications to chemistry, biology, and physics

    CERN Document Server

    Berne, Bruce J

    2000-01-01

    Lasers play an increasingly important role in a variety of detection techniques, making inelastic light scattering a tool of growing value in the investigation of dynamic and structural problems in chemistry, biology, and physics. Until the initial publication of this work, however, no monograph treated the principles behind current developments in the field.This volume presents a comprehensive introduction to the principles underlying laser light scattering, focusing on the time dependence of fluctuations in fluid systems; it also serves as an introduction to the theory of time correlation f

  20. Stochastic narrow escape in molecular and cellular biology analysis and applications

    CERN Document Server

    Holcman, David

    2015-01-01

    This book covers recent developments in the non-standard asymptotics of the mathematical narrow escape problem in stochastic theory, as well as applications of the narrow escape problem in cell biology. The first part of the book concentrates on mathematical methods, including advanced asymptotic methods in partial equations, and is aimed primarily at applied mathematicians and theoretical physicists who are interested in biological applications. The second part of the book is intended for computational biologists, theoretical chemists, biochemists, biophysicists, and physiologists. It includes a summary of output formulas from the mathematical portion of the book and concentrates on their applications in modeling specific problems in theoretical molecular and cellular biology. Critical biological processes, such as synaptic plasticity and transmission, activation of genes by transcription factors, or double-strained DNA break repair, are controlled by diffusion in structures that have both large and small sp...

  1. Blueprints for green biotech: development and application of standards for plant synthetic biology.

    Science.gov (United States)

    Patron, Nicola J

    2016-06-15

    Synthetic biology aims to apply engineering principles to the design and modification of biological systems and to the construction of biological parts and devices. The ability to programme cells by providing new instructions written in DNA is a foundational technology of the field. Large-scale de novo DNA synthesis has accelerated synthetic biology by offering custom-made molecules at ever decreasing costs. However, for large fragments and for experiments in which libraries of DNA sequences are assembled in different combinations, assembly in the laboratory is still desirable. Biological assembly standards allow DNA parts, even those from multiple laboratories and experiments, to be assembled together using the same reagents and protocols. The adoption of such standards for plant synthetic biology has been cohesive for the plant science community, facilitating the application of genome editing technologies to plant systems and streamlining progress in large-scale, multi-laboratory bioengineering projects.

  2. 75 FR 4570 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing..., Program in Physical Biology, Section on Intracellular Interactions, is seeking statements of capability...

  3. Compatibility analysis of 3D printer resin for biological applications

    KAUST Repository

    Sivashankar, Shilpa

    2016-08-30

    The salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present work. The incompatibility of three-dimensional printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification are reported. The compatibility of the material to build microfluidic devices was evaluated in three different ways: (i) determining if the ultraviolet (UV) cured resin inhibits the polymerase chain reaction (PCR), i.e. testing devices for PCR compatibility; (ii) observing agglutination complex formed on the surface of the UV cured resin when anti-C-reactive protein (CRP) antibodies and CRP proteins were allowed to agglutinate; and (iii) by culturing human embryonic kidney cell line cells and testing for its attachment and viability. It is shown that only a few among four in its native form could be used for fabrication of microchannels and that had the least effect on biological molecules that could be used for PCR and protein interactions and cells, whereas the others were used after treating the surface. Importance in building lab-on-chip/micrototal analysis systems and organ-on-chip devices is found.

  4. Characterizing seamless ligation cloning extract for synthetic biological applications.

    Science.gov (United States)

    Messerschmidt, Katrin; Hochrein, Lena; Dehm, Daniel; Schulz, Karina; Mueller-Roeber, Bernd

    2016-09-15

    Synthetic biology aims at designing and engineering organisms. The engineering process typically requires the establishment of suitable DNA constructs generated through fusion of multiple protein coding and regulatory sequences. Conventional cloning techniques, including those involving restriction enzymes and ligases, are often of limited scope, in particular when many DNA fragments must be joined or scar-free fusions are mandatory. Overlap-based-cloning methods have the potential to overcome such limitations. One such method uses seamless ligation cloning extract (SLiCE) prepared from Escherichia coli cells for straightforward and efficient in vitro fusion of DNA fragments. Here, we systematically characterized extracts prepared from the unmodified E. coli strain DH10B for SLiCE-mediated cloning and determined DNA sequence-associated parameters that affect cloning efficiency. Our data revealed the virtual absence of length restrictions for vector backbone (up to 13.5 kbp) and insert (90 bp to 1.6 kbp). Furthermore, differences in GC content in homology regions are easily tolerated and the deletion of unwanted vector sequences concomitant with targeted fragment insertion is straightforward. Thus, SLiCE represents a highly versatile DNA fusion method suitable for cloning projects in virtually all molecular and synthetic biology projects. PMID:27311554

  5. Quantum Information Biology: From Information Interpretation of Quantum Mechanics to Applications in Molecular Biology and Cognitive Psychology

    Science.gov (United States)

    Asano, Masanari; Basieva, Irina; Khrennikov, Andrei; Ohya, Masanori; Tanaka, Yoshiharu; Yamato, Ichiro

    2015-10-01

    We discuss foundational issues of quantum information biology (QIB)—one of the most successful applications of the quantum formalism outside of physics. QIB provides a multi-scale model of information processing in bio-systems: from proteins and cells to cognitive and social systems. This theory has to be sharply distinguished from "traditional quantum biophysics". The latter is about quantum bio-physical processes, e.g., in cells or brains. QIB models the dynamics of information states of bio-systems. We argue that the information interpretation of quantum mechanics (its various forms were elaborated by Zeilinger and Brukner, Fuchs and Mermin, and D' Ariano) is the most natural interpretation of QIB. Biologically QIB is based on two principles: (a) adaptivity; (b) openness (bio-systems are fundamentally open). These principles are mathematically represented in the framework of a novel formalism— quantum adaptive dynamics which, in particular, contains the standard theory of open quantum systems.

  6. Rethinking biology instruction: The application of DNR-based instruction to the learning and teaching of biology

    Science.gov (United States)

    Maskiewicz, April Lee

    Educational studies report that secondary and college level students have developed only limited understandings of the most basic biological processes and their interrelationships from typical classroom experiences. Furthermore, students have developed undesirable reasoning schemes and beliefs that directly affect how they make sense of and account for biological phenomena. For these reasons, there exists a need to rethink instructional practices in biology. This dissertation discusses how the principles of Harel's (1998, 2001) DNR-based instruction in mathematics could be applied to the teaching and learning of biology. DNR is an acronym for the three foundational principles of the system: Duality, Necessity, and Repeated-reasoning. This study examines the application of these three principles to ecology instruction. Through clinical and teaching interviews, I developed models of students' existing ways of understanding in ecology and inferred their ways of thinking. From these models a hypothetical learning trajectory was developed for 16 college level freshmen enrolled in a 10-week ecology teaching experiment. Through cyclical, interpretive analysis I documented and analyzed the evolution of the participants' progress. The results provide empirical evidence to support the claim that the DNR principles are applicable to ecology instruction. With respect to the Duality Principle, helping students develop specific ways of understanding led to the development of model-based reasoning---a way of thinking and the cognitive objective guiding instruction. Through carefully structured problem solving tasks, the students developed a biological understanding of the relationship between matter cycling, energy flow, and cellular processes such as photosynthesis and respiration, and used this understanding to account for observable phenomena in nature. In the case of intellectual necessity, the results illuminate how problem situations can be developed for biology learners

  7. The post-closure radiological safety case for a spent fuel repository in Sweden - An international peer review of the SKB license-application study of March 2011

    International Nuclear Information System (INIS)

    Sweden is at the forefront among countries developing plans for a deep geological repository of highly radioactive waste. There is no such repository in operation yet worldwide, but Sweden, Finland and France are approaching the licensing stage. At the request of the Swedish government, the NEA organised an international peer review of the post-closure radiological safety case produced by the Swedish Nuclear Fuel and Waste Management Company (SKB) in support of the application for a general licence to construct and operate a spent nuclear fuel geological repository in the municipality of Oesthammar. The purpose of the review was to help the Swedish government, the public and relevant organisations by providing an international reference regarding the maturity of SKB's spent fuel disposal programme vis-a-vis best practices in long-term disposal safety and radiological protection. The International Review Team (IRT) consisted of ten international specialists, who were free of conflict of interest with the SKB and brought complementary expertise to the review. This report provides the background and findings of the international peer review. The review's findings are presented at several levels of detail in order to be accessible to both specialist and non-specialist readers

  8. 77 FR 4806 - Eugene Water and Electric Board; Notice of Application for Surrender of License and Soliciting...

    Science.gov (United States)

    2012-01-31

    ... Energy Regulatory Commission Eugene Water and Electric Board; Notice of Application for Surrender of... Water and Electric Board. e. Name of Project: Blue River Project. f. Location: The proposed project... construction on October 28, 1993, by signing a contract for the manufacture of generating units and making...

  9. 75 FR 69063 - Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-11-10

    ... Energy Regulatory Commission Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application... 22, 2010, Port Bailey Wild Enterprises, LLC (transferor) and PB Energy, Inc. (transferee) filed a.... Shane II and Anita Shane, PB Energy, Inc., P.O. Box KPY, Kodiak, AK 99697, (360) 989-9843...

  10. 76 FR 7831 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-02-11

    ...: Grand River Dam Authority. e. Name of Project: Markham Ferry Project. f. Location: The project is located on the Grand River (also known as the Neosho River) in Mayes County, Oklahoma. g. Pursuant to... Energy Regulatory Commission Grand River Dam Authority; Notice of Application for Amendment of...

  11. 78 FR 47800 - License Renewal Application for Byron Station, Units 1 and 2; Exelon Generation Company, LLC

    Science.gov (United States)

    2013-08-06

    ... authorized to develop and enforce relevant environmental standards; c. Affected State and local government agencies, including those authorized to develop and enforce relevant environmental standards; d. Any... Register on June 13, 2013 (78 FR 35646). A notice of acceptance for docketing of the application...

  12. 78 FR 46379 - Exelon Generation Company, LLC, License Renewal Application for Braidwood Station, Units 1 and 2

    Science.gov (United States)

    2013-07-31

    ... authorized to develop and enforce relevant environmental standards; c. Affected State and local government agencies, including those authorized to develop and enforce relevant environmental standards; d. Any... Register on June 13, 2013 (78 FR 35646). A notice of acceptance for docketing of the application...

  13. 77 FR 40142 - Applications for Exemption: Commercial Driver's License (CDL) and Hours-of-Service (HOS) of Drivers

    Science.gov (United States)

    2012-07-06

    ... May 21, 2012, and of Underwater Construction Corporation (Underwater) on May 29, 2012. On June 4, 2012....regulations.gov at any time, or to Room W12-140, DOT Building, 1200 New Jersey Ave. SE., Washington, DC... the case with the denials announced today. Applications for Exemption Rotel, Underwater,...

  14. Testing of Synthetic Biological Membranes for Forward Osmosis Applications

    Science.gov (United States)

    Parodi, Jurek; Mangado, Jaione Romero; Stefanson, Ofir; Flynn, Michael; Mancinelli, Rocco; Kawashima, Brian; Trieu, Serena; Brozell, Adrian; Rosenberg, Kevan

    2016-01-01

    Commercially available forward osmosis membranes have been extensively tested for human space flight wastewater treatment. Despite the improvements achieved in the last decades, there is still a challenge to produce reliable membranes with anti-fouling properties, chemical resistance, and high flux and selectivity. Synthetic biological membranes that mimic the ones present in nature, which underwent millions of years of evolution, represent a potential solution for further development and progress in membrane technology. Biomimetic forward osmosis membranes based on a polymeric support filter and coated with surfactant multilayers have been engineered to investigate how different manufacturing processes impact the performance and structure of the membrane. However, initial results of the first generation prototype membranes tests reveal a high scatter in the data, due to the current testing apparatus set up. The testing apparatus has been upgraded to improve data collection, reduce errors, and to allow higher control of the testing process.

  15. Application of scanning electrochemical microscopy to biological samples.

    Science.gov (United States)

    Lee, C; Kwak, J; Bard, A J

    1990-03-01

    The scanning electrochemical microscope can be used in the feedback mode in two-dimensional scans over biological substrates to obtain topographic information at the micrometer level. In this mode, the effect of distance between a substrate (either conductive or insulating) and a scanning ultramicroelectrode tip on the electrolytic current flowing at the tip is recorded as a function of the tip x-y position. Scans of the upper surface of a grass leaf and the lower surface of a Ligustrum sinensis leaf (which show open stomata structures) immersed in aqueous solution are shown. Scans of the upper surface of an elodea leaf in the dark and under irradiation, where the tip reaction is the reduction of oxygen produced by photosynthesis, demonstrate the possibility of obtaining information about the distribution of reaction sites on the substrate surface. PMID:2308933

  16. Biclustering methods: biological relevance and application in gene expression analysis.

    Science.gov (United States)

    Oghabian, Ali; Kilpinen, Sami; Hautaniemi, Sampsa; Czeizler, Elena

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes). An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical) methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1) we examine how well the considered (bi)clustering methods differentiate various sample types; (2) we evaluate how well the groups of genes discovered by the (bi)clustering methods are annotated with similar Gene Ontology categories; (3) we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4) we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples. PMID:24651574

  17. Biclustering methods: biological relevance and application in gene expression analysis.

    Directory of Open Access Journals (Sweden)

    Ali Oghabian

    Full Text Available DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering methods where genes (or respectively samples are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes. An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1 we examine how well the considered (biclustering methods differentiate various sample types; (2 we evaluate how well the groups of genes discovered by the (biclustering methods are annotated with similar Gene Ontology categories; (3 we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4 we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples.

  18. Porous titanium for biomedical applications : development, characterization and biological evaluation

    NARCIS (Netherlands)

    Li, JiaPing

    2007-01-01

    Metallic biomaterials have so far shown the greatest potential to be the basis of implants for long-term load-bearing orthopedic and dental applications, owing to their excellent mechanical strength when compared to alternative biomaterials, such as polymers and ceramics. Particularly titanium and i

  19. Applications of Magnetic Micro- and Nanoparticles in Biology and Medicine

    Science.gov (United States)

    Dobson, J.

    2005-12-01

    Magnetic nanoparticles were first proposed for biomedical applications in the 1970s - primarily as targeted drug delivery vehicles and MRI contrast agents. Since that time, such particles have found application in a variety of biomedical techniques. In addition to drug delivery, magnetic nanoparticles are now used routinely as MRI contrast agents as well as for magneto-immunoassay and cell sorting. More recently, magnetic micro- and nanoparticles have been used to investigate and manipulate cellular processes both in vitro and in vivo. In addition, biogenic magnetic nanoparticles are also produced in the human body. The iron storage protein, ferritin, consists of a superparamagnetic ferrihydrite core and biogenic magnetite (a ferrimagnet) has also been found in the brain and other organs. Though the role of ferritin and several other magnetic iron oxides in the body is well understood, the origin and role of biogenic magnetite is only now coming to light - and this may have profound implications for our understanding of neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases. This talk will review applications related to magnetic particle-mediated activation of cellular processes for tissue engineering applications and novel methods of magnetofection which have the potential to provide enhanced transfection for non-viral therapeutic gene delivery. It will also briefly highlight new techniques recently developed for the mapping and characterization of magnetic iron compounds related to neurodegenerative diseases and how rock magnetic techniques have been adapted to study magnetic iron compounds in the brain and other organs.

  20. Applications of Discrete Molecular Dynamics in biology and medicine.

    Science.gov (United States)

    Proctor, Elizabeth A; Dokholyan, Nikolay V

    2016-04-01

    Discrete Molecular Dynamics (DMD) is a physics-based simulation method using discrete energetic potentials rather than traditional continuous potentials, allowing microsecond time scale simulations of biomolecular systems to be performed on personal computers rather than supercomputers or specialized hardware. With the ongoing explosion in processing power even in personal computers, applications of DMD have similarly multiplied. In the past two years, researchers have used DMD to model structures of disease-implicated protein folding intermediates, study assembly of protein complexes, predict protein-protein binding conformations, engineer rescue mutations in disease-causative protein mutants, design a protein conformational switch to control cell signaling, and describe the behavior of polymeric dispersants for environmental cleanup of oil spills, among other innovative applications.