WorldWideScience

Sample records for biologics license applications

  1. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  2. Support for the revocation of general safety test regulations in biologics license applications.

    Science.gov (United States)

    Evans, Dana M; Thorn, Jennifer M; Arch-Douglas, Katherine; Sperry, Justin B; Thompson, Bruce; Davis, Heather L; McCluskie, Michael J

    2016-05-01

    The United States Food and Drug Administration recently removed the requirement for a General Safety Test (GST) for biologics in the Code of Federal Regulations (21 CFR 610.11). The GST, as well as abnormal toxicity (European Pharmacopeia) and innocuity tests (World Health Organization), were designed to test for extraneous toxic contaminants on each product lot intended for human use. Tests require one-week observations for general health and weight following injection of specified volumes of product batches into guinea pigs and mice. At the volumes specified, dose-related toxicity may result when the product is pharmacologically active in rodents. With vaccines, required doses may be > 3 logs higher than intended human dose on a weight-adjusted basis and if an immune modulatory adjuvant is included, systemic immune hyperactivation may cause toxicity. Herein, using the CpG/alum adjuvant combination we evaluated the different test protocols and showed their unsuitability for this adjuvant combination. PMID:26996102

  3. 9 CFR 102.4 - U.S. Veterinary Biologics Establishment License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biologics... LICENSES FOR BIOLOGICAL PRODUCTS § 102.4 U.S. Veterinary Biologics Establishment License. (a) Before a U.S. Veterinary Biologics Establishment License will be issued by the Administrator for any establishment,...

  4. 76 FR 55909 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-09-09

    ..., Application Type: New NVO License. International Movers Network Inc. (NVO), 70-20 73rd Street, Glendale, NY..., President, Application Type: New NVO License. Unity Holdings, Inc. (NVO), 2860 W. State Road 84, Suite 118.../Treasurer (Qualifying Individual), Application Type: New NVO License. Echo Trans World Inc. (NVO), 462...

  5. 9 CFR 102.5 - U.S. Veterinary Biological Product License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biological Product... BIOLOGICAL PRODUCTS § 102.5 U.S. Veterinary Biological Product License. (a) Authorization to produce each biological product shall be specified on a U.S. Veterinary Biological Product License, issued by...

  6. 76 FR 78007 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-15

    ... (OFF), 7823 New London Drive, Springfield, VA 22153, Officers: Feras Hindi, Member, (Qualifying Individual), Ruba Hindi, Member, Application Type: New OFF License. Kemka USA Limited Liability Company...

  7. 77 FR 61752 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-11

    ... Embarque Corporation (NVO & OFF), 376 Totowa Avenue, Paterson, NJ 07502, Officers: Robert Guerra, President (QI), Henry Guerra, Vice President, Application Type: New NVO & OFF License. Ocean Line Logistics...

  8. 21 CFR 310.4 - Biologics; products subject to license control.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Biologics; products subject to license control. 310.4 Section 310.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... to license control. (a) If a drug has an approved license under section 351 of the Public...

  9. 78 FR 3424 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-01-16

    ... Ocean Transportation Intermediary License Applicants The Commission gives notice that the following applicants have filed an application for an Ocean Transportation Intermediary (OTI) license as a Non-Vessel-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF) pursuant to section 19 of the...

  10. LTO License Application Project NPP Borssele

    International Nuclear Information System (INIS)

    Borssele NPP plans to extend its operating life with 20 years until 2034. Borssele has started the project LTO 'bewijsvoering' (LTO 'Justification') in order to meet the requirements of the Dutch regulator. The outline of the project is based on IAEA safety guide 57 'Safe Long Term Operation of Nuclear Power Plants'. This paper describes the contents and coherence of the different parts in the project and how these respond to the IAEA guidelines on LTO. The goal of the project LTO 'bewijsvoering' is to ensure that safety and safety relevant systems, structures and components continue to perform their intended functions during long term operation. The outcome of the project LTO 'bewijsvoering' will be used for a license change application and this will be submitted to the Dutch regulator KFD for approval of prolonged operation of Borssele NPP after 2013. (author)

  11. 77 FR 20398 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-04-04

    ... Individual), Christopher J. Alf, Chairman/CEO, Application Type: New OFF License. Novargo Inc. (NVO), 38..., President/CEO, Application Type: New NVO & OFF License. Lars Courier, Inc. dba Lars International Freight...: Mark Bongean, Vice President (Operations), (Qualifying Individual), Sebastian Tshackert,...

  12. 75 FR 60124 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-29

    ..., Officers: Edward H. Lee, Secretary (Qualifying Individual), Darren Kim, Chairman/ President/CFO...), George W. Pasha, IV, Member/President/CEO, Application Type: New NVO & OFF License RDD Freight... (Qualifying Individual), Victor L. Sheng, Director/ ] President/CEO, Application Type: New NVO License...

  13. 76 FR 72409 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-23

    ...), Rolf E. Habben-Jansen, Chairman, Application Type: New NVO License. Daybreak Logistics, Inc. (NVO & OFF... Individual), Ming Wu, CEO/CFO/Secretary, Application Type: New NVO & OFF License. Trans-Pak International.... Webgistix Corporation (OFF), 127 E. Warm Springs Road, Las Vegas, NV 89119; Officer: Joseph A. Disorbo,...

  14. 77 FR 3773 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-01-25

    ... Ocean Transportation Intermediary License; Applicants Notice is hereby given that the following...-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF)--Ocean Transportation Intermediary (OTI...). Application Type: New OFF License. Kamino International Transport, Inc. dba Kamino Ocean Line (NVO &...

  15. 78 FR 25740 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-02

    ... to Fesco Integrated Transport North Neptune Shipping Limited dba Novalink Logistics (NVO), 2085 S... Leonard, Member (QI), Application Type: New NVO & OFF License Maritime and Intermodal Logistics Systems..., OH 43219, Officer: Nicholas Armah, Member (QI), Application Type: New NVO License Seacoast...

  16. 76 FR 68225 - License Renewal Application for Purdue University

    Science.gov (United States)

    2011-11-03

    ... COMMISSION License Renewal Application for Purdue University AGENCY: Nuclear Regulatory Commission. ACTION... Facility Operating License No. R-087 (``Application''), which currently authorizes Purdue University (the licensee) to operate the Purdue University Reactor (PUR-1) at a maximum steady-state thermal power of...

  17. 78 FR 75345 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-11

    ... President and Sales Manager (QI), Teresita Del Calvo, Manager. Application Type: New NVO & OFF License..., Fort Lauderdale, FL 33309. Officers: Ulrike Bracken, Manager (QI), Philip Stachow, Managing Member... Manager (QI), Unni Krishnan Nair, President. Application Type: New NVO & OFF License. Martik LLC...

  18. 75 FR 52343 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-25

    ...: Xiao Chun Li, Vice President (Qualifying Individual), Yan Yang, CEO, Application Type: New NVO & OFF..., Chairman/Director, Application Type: New NVO License, United Marine Lines, L.L.C. (NVO), 201 Sevilla...

  19. 75 FR 4560 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-01-28

    ... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to section...-Operating Common Carrier--Ocean Transportation Intermediary Applicants: Doma Consolidating Inc. dba...

  20. 75 FR 8720 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-02-25

    ...-Operating Common Carrier--Ocean Transportation Intermediary Applicants: Eastern Logistics LLC, 6 Elna Ct... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to...

  1. A Novel Application Licensing Framework for Mobile Cloud Environment

    OpenAIRE

    Khan, Atta ur Rehman; Othman, Mazliza; Khan, Abdul Nasir

    2013-01-01

    Mobile cloud computing is a new technology that enhances smartphone applications capabilities in terms of performance, energy efficiency, and execution support. These features are achieved via computation offloading technique that is supported by specialized mobile cloud application development models. However, the cloud-enabled applications are prone to application piracy issue for which the traditional licensing frameworks are of no use. Therefore, a new licensing framework is required to c...

  2. NUCLEAR SAFETY DESIGN BASES FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-03-08

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111 [DIRS 156605] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113 [DIRS 156605] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  3. Nuclear Safety Design Base for License Application

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-09-29

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111(b) [DIRS 173273] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113(b) and (c) [DIRS 173273] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  4. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-02-17

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified.

  5. Requirements for Foreign and Domestic Establishment Registration and Listing for Human Drugs, Including Drugs That Are Regulated Under a Biologics License Application, and Animal Drugs. Final rule.

    Science.gov (United States)

    2016-08-31

    The Food and Drug Administration (FDA) is amending its regulations governing drug establishment registration and drug listing. These amendments reorganize, modify, and clarify current regulations concerning who must register establishments and list human drugs, human drugs that are also biological products, and animal drugs. The final rule requires electronic submission, unless waived in certain circumstances, of registration and listing information. This rulemaking pertains to finished drug products and to active pharmaceutical ingredients (APIs) alone or together with one or more other ingredients. The final rule describes how and when owners or operators of establishments at which drugs are manufactured or processed must register their establishments with FDA and list the drugs they manufacture or process. In addition, the rule makes certain changes to the National Drug Code (NDC) system. We are taking this action to improve management of drug establishment registration and drug listing requirements and make these processes more efficient and effective for industry and for us. This action also supports implementation of the electronic prescribing provisions of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA) and the availability of current drug labeling information through DailyMed, a computerized repository of drug information maintained by the National Library of Medicine. PMID:27580511

  6. 78 FR 21365 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-10

    ... Officer (QI), Rosemary Myers, CEO, Application Type: New NVO & OFF License. Full Hull Logistics, LLC (NVO... 30096, Officers: Christopher J. Reilly, Vice President (QI), Neal Baines, Chairman of the...

  7. 76 FR 67730 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-02

    ... License Kimberly Ann Martin dba KNJs Shipping Solutions (OFF), 951 Denton Court, Suite 201, Crystal Lake, IL 60014, Officer: Kimberly A. Martin, Sole Proprietor (Qualifying Individual), Application Type: New..., NY 11413, Officers: James Minutello, Vice President (Qualifying Individual), Simon Oxley,...

  8. Fort Calhoun Station, Unit 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    Application for construction and operating licenses for Calhoun-2 Reactor is presented. Financial data concerning the Omaha Public Power District and the Nebraska Public Power District are included. (DCC)

  9. 76 FR 12962 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-03-09

    ..., IL 60010. Officer: Machiko K. Hamada, President/CEO (Qualifying Individual), Application Type: New... Individual), Richard D. Jennings, CEO, Application Type: New NVO & OFF License. Mitsui-Soko (U.S.A... (Qualifying Individual), Hiroyuki Hamano, Chairman/Director, Application Type: QI Change. Oceane...

  10. 78 FR 14792 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-07

    ... 91733. Officers: Alex C. Huang, CEO (QI); Wei Zheng, Shareholder. Application Type: New NVO & OFF.... Officers: Richard L. Giovannone, President (QI); Miranda L. Lou, Chairman. Application Type: QI Change.... Zavaleta, Secretary (QI); Patricia A. Whaley, CEO. Application Type: New NVO & OFF License Triple...

  11. 75 FR 39529 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-09

    .... Hamilton, Manager/Chairman/CEO, Application Type: Trade Name Change CIL Freight Inc. (OFF), 1990 Lakeside... (Qualifying Individual), Alfred Kuehlewind, CEO/Secretary/Treasurer, Application Type: New OFF & NVO License.... Officers: Jie Zhang, Secretary (Qualifying Individual), Yong Li, President/CEO, Application Type: QI...

  12. 77 FR 37044 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-20

    ..., Chairman/CEO (Qualifying Individual), Application Type: License Transfer. Bayanihan Cargo International Inc.../CEO/Secretary/CFO (Qualifying Individual), Application Type: Trade Name Change. Aqua Gulf Transport... President (Qualifying Individual), Tae Soo Kim, President/CEO/Sec/Treasurer/CFO, Application Type: New...

  13. 76 FR 70145 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-10

    ... (Qualifying Individual). Application Type: Name Change/Add NVO Service. Investment Logistic Solution Corp (NVO... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION... applicants have filed with the Federal Maritime Commission an application for a license as a...

  14. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    Energy Technology Data Exchange (ETDEWEB)

    Uleck, R.B.; DeFino, C.V. [Nuclear Regulatory Commission, Washington, DC (United States)

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health and safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.

  15. 78 FR 48870 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-12

    ..., Application Type: QI Change. D. Martin LLC (OFF), 2915 Quail Run Drive, Humble, TX 77396, Officer: Dorsille Martin, Managing Member (QI), Application Type: New OFF License. Global Customs Services, LLC (NVO & OFF...., Grand Rapids, MI 49512, Officers: Peter G. Gonzales, Vice President (QI), James Ward, COO,...

  16. 77 FR 64991 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-24

    ...), Joosup Jung, CEO. Application Type: New NVO & OFF License. E.T.H. Cargo Services Inc. (OFF), Av. Galicia..., Miami, FL 33178. Officers: Chris Merritt, Vice President (QI), John H. Williford, President. Application... & OFF), 1400 Glenn Curtiss Street, Carson, CA 90746. Officers: Thomas Donahue, III, Vice President...

  17. 76 FR 9015 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-16

    .../Treasurer (Qualifying Individual). Application Type: New NVO & OFF. Mega Supply Chain Solutions, Inc. (NVO.... Daley, President. Application Type: New OFF License. American Global Logistics, LLC (NVO & OFF), 53.... dba Citic Global Logistics dba Chimerica Global Logistics (NVO), 817 W. Beverly Blvd., 204,...

  18. 76 FR 3636 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-01-20

    ...: Trade Name Change & Add NVO Service. Pavao Sosic dba C.O. Logistic (OFF), 3711 Country Club Drive, 6... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION... applicants have filed with the Federal Maritime Commission an application for a license as a...

  19. 78 FR 48435 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-08

    ...), 13101 Moore Street, Cerritos, CA 90703, Officers: Ki Hyeon Lee, CFO (QI), Seong Won Lee, CEO... (OFF), 320 Harbor Way, South San Francisco, CA 94080, Officers: Raymond Wong, Chairman (QI), John Tree, CEO, Application Type: License Transfer to Raymond Express International, LLC. RMT Logistics Inc....

  20. 10 CFR 30.32 - Application for specific licenses.

    Science.gov (United States)

    2010-01-01

    ..., the intended use and associated operating experience, and the results of a recent leak test. (h) As... Energy NUCLEAR REGULATORY COMMISSION RULES OF GENERAL APPLICABILITY TO DOMESTIC LICENSING OF BYPRODUCT..., and documentation that each individual meets the requirements of an authorized nuclear pharmacist...

  1. 76 FR 41258 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-13

    ... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier (NVO) and/or Ocean Freight Forwarder (OFF)--Ocean Transportation Intermediary (OTI.../Business Structure Change. Cardinal Health 200, LLC (NVO & OFF), 7000 Cardinal Place, Dublin, OH...

  2. 75 FR 17743 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-04-07

    ...-Vessel-Operating Common Carrier--Ocean Transportation Intermediary: HPK Logistics (USA) Inc., 727 Brea... Ocean Transportation Intermediary License Applicants Notice is hereby given that the following...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to...

  3. 78 FR 28845 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-16

    ..., Application Type: New OFF License AZ Freight International Inc. (NVO & OFF), 18311 Railroad Street, City of... Change Contract Logistics, LLC (NVO), 4911 North Portland Avenue, Suite 200, Oklahoma City, OK 73112... Trade Name Smart Lines Worldwide Feiliks Global Logistics Corporation (NVO), 176-20 S. Conduit...

  4. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    ...), 1825-C Cross Beam Drive, Charlotte, NC 28217, Officer: David E. Sitton, Managing Member (Qualifying..., Maritime NVOCC (OFF), 2081 Raritan Road, Scotch Plains, NJ 07076, Officers: Robin Lynch, Managing Member (Qualifying Individual), Gina Lynch, Member, Application Type: License Transfer. Orion SLM LLC (NVO &...

  5. 77 FR 49445 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-08-16

    ... Global Logistics. Global Shipping Partners, LLC (NVO), 437 Perrie Drive, 202, Elk Grove Village, IL 60007... II, New Delhi-110020, India, Officers: Siddharth Khera, Vice President (Qualifying Individual.... Montero, Vice President, Application Type: New NVO License. TOC Logistics International, LLC (NVO &...

  6. 75 FR 40837 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-14

    ...), Virgil Hale, President, Application Type: New OFF License. AFL International Logistics Group LLC (NVO... Maritime USA Inc. (NVO), 17, Contractor Building, 1st Floor, 15, Vajukotak Marg, Fort, Mumbai 400001 India... Name Change. Jupiter Airline Services, Inc. dba Mercury Logistics (NVO), 5456 McConnell Avenue,...

  7. 77 FR 59193 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-09-26

    .... CTS Global Logistics (Georgia) Inc. dba CTS Global Supply Chain Solutions (NVO & OFF), 5192 Southridge.... Rivera, President (QI), Howard Helfer, Vice President, Application Type: New OFF License. Bring Logistics... Logistics, LLC (NVO & OFF), 4911 N. Portland Avenue, Suite 200, Oklahoma City, OK 73112, Officers: Thomas...

  8. 77 FR 38288 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-27

    .... dba Legacy Supply Chain Services (NVO & OFF), 5360 Capital Ct., 100, Reno, NV 89502. Officers: Russ P... Individual). Alero A. Odinjor, Secretary. Application Type: New NVO License. Benchmark Worldwide Logistics... Change. Freight Logistics Services USA Forwarding Ltd (OFF), 15955 W. Hardy Street, 222, Houston,...

  9. 78 FR 69852 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-21

    .... dba CTS Global Supply Chain Solutions (NVO & OFF), 5192 Southridge Parkway, Suite 117, Atlanta, GA... Amex Logistics Corp (NVO & OFF), 1970 NW 70th Avenue, Miami, FL 33126. Officers: Jorge X. de Tuya, Vice President (QI), Orestes F. Romero, President, Application Type: New NVO & OFF License. Canfleet...

  10. 77 FR 45610 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-08-01

    ... telephone at (202) 523-5843 or by email at OTI@fmc.gov . Access Supply Chain Services LLC (NVO), 65 West 5th... President, Application Type: New NVO License. Aequus Worldwide Logistics Inc. (NVO), 319 E. Butterfield Road... Freight, Inc. FGN Global Logistics, Inc. (NVO & OFF), 4770 Highway 165, Meggett, SC 29449, Officers:...

  11. 47 CFR 80.55 - Application for a fleet station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a fleet station license. 80.55... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.55 Application for a fleet... different vessels on the same application. Under these circumstances a fleet station license may be...

  12. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    This document is a compilation and source list of nuclear safety criteria that the Nuclear Regulatory Commission (NRC) applies to licensed reactors; it can be used by DOE and DOE contractors to identify NRC criteria to be evaluated for application to the DOE reactors under their cognizance. The criteria listed are those that are applied to the areas of nuclear safety addressed in the safety analysis report of a licensed reactor. They are derived from federal regulations, USNRC regulatory guides, Standard Review Plan (SRP) branch technical positions and appendices, and industry codes and standards

  13. 21 CFR 515.21 - Refusal to approve a medicated feed mill license application.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Refusal to approve a medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.21 Refusal to approve a medicated feed mill license application. (a)...

  14. 78 FR 36014 - Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-14

    ... License Applications in the Federal Register (78 FR 25349-25351) advising the public that nautical miles... Maritime Administration Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port AGENCY: Maritime Administration, Department of Transportation. ACTION: Notice of...

  15. Fuel Receiving and Storage Station. License application, amendment 7

    International Nuclear Information System (INIS)

    Amendment No. 7 to Allied-General Nuclear Services application for licensing of the Fuel Receiving and Storage Station consists of revised pages for: Amendment No. 7 to AG-L 105, ''Technical Description in Support of Application for FRSS Operation''; Amendment No. 1 to AG-L 105A, ''Early Operation of the Service Concentrator''; and Amendment No. 2 to AG-L 110, ''FRSS Summary Preoperational Report.''

  16. Technical Guidance Document For License Application Preparation, Revision

    International Nuclear Information System (INIS)

    This introduction provides information that applies to all chapters of the Technical Guidance Document for License Application Preparation. Authors preparing the License Application (LA) shall use this document for guidance and must read this Introduction and Appendix B before writing their respective sections. This technical guidance document (TGD) was developed by the Civilian Radioactive Waste Management System (CRWMS) Management and Operating Contractor (M and O) for the U.S. Department of Energy (DOE). The document was prepared by an M and O team led by the M and O Licensing group. This document was prepared using the proposed 10 CFR 63 (64 FR 8640) as the rule governing the granting of a license for the DOE to construct a potential repository at Yucca Mountain, and to receive and possess source, special nuclear, and by-product materials at the potential geologic repository. The DOE comments submitted to the U.S. Nuclear Regulatory Commission (NRC) on the proposed 10 CFR 63 (64 FR 8640), as contained in the ''Interim Guidance Pending Issuance of New Nuclear Regulatory Commission (NRC) Regulations for Yucca Mountain, Nevada'' (Dyer and Horton 1999), have been incorporated into this TGD

  17. 77 FR 41206 - Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control...

    Science.gov (United States)

    2012-07-12

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan...

  18. 77 FR 58419 - Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control...

    Science.gov (United States)

    2012-09-20

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for Instrumentation and Control..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan and Acceptance...

  19. 76 FR 63668 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2011-10-13

    ... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format and... Reviewing Applications for the Licensing of Non-Power Reactors: Standard Review Plan and Acceptance...

  20. License renewal - an idea whose time has come. Hatch nuclear plant license renewal program: an actual example of application of the license renewal rule to the Intake Structure

    International Nuclear Information System (INIS)

    After the NRC issued a revised license renewal rule in May 1995, the nuclear industry focussed on developing generic industry for implementing the rule and testing the guidance through various demonstration programs and work products in conjunction with the NRC. In addition, plant-specific programs also proceeded forward. These activities show that implementation issues continue to exist. Since the issuance of the rule, the NRC has issued a draft standard review plan for license renewal (SRP-LR), working draft, September 1997. Southern Nuclear Operating Company (SNC) has begun development work on a license renewal application for Plant Hatch Units 1 and 2. Plant Hatch Units 1 and 2 are BWR 4, Mark I plants whose operating licenses expire in 2014 and 2018, respectively. The Plant Hatch initiative also involves teaming with other boiling water reactors (BWRs) to develop the license renewal technology within the BWR fleet, and to support Plant Hatch by providing an oversight role for the application process. The teaming effort involved two other utilities, each being assigned to prepare a common report on a mechanical system or a structure. The common report could be presented to the NRC with modifications to suit the individual plants, thereby saving time and money, and hopefully resulting in quicker approval by the NRC. The desired license renewal process end result is a renewed license with up to a 20 year extension (10CFR 54.31(b)). (orig.)

  1. 76 FR 79203 - Prospective Grant of Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines

    Science.gov (United States)

    2011-12-21

    ... contemplating the grant of an exclusive license to practice the inventions embodied in Patent Applications USSN... business in 1520 Prairie Drive, Worthington, MN 56187. The patent rights in this invention have been... considered. ADDRESSES: Requests for a copy of the patent application, inquiries, comments and other...

  2. 15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

    Science.gov (United States)

    2010-01-01

    ... all documentation submitted in support of the application. In addition to reviewing the item and end... intelligence information. To the maximum extent possible, BIS will make licensing decisions without referral of... biological weapons proliferation reasons or destined for countries and/or end uses of concern. In...

  3. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) Order DOE 5480.6, Safety of Department of Energy-Owned Nuclear Reactors, establishes reactor safety requirements to assure that reactors are sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that adequately protects health and safety and is in accordance with uniform standards, guides, and codes which are consistent with those applied to comparable licensed reactors. This document identifies nuclear safety criteria applied to NRC [Nuclear Regulatory Commission] licensed reactors. The titles of the chapters and sections of USNRC Regulatory Guide 1.70, Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants, Rev. 3, are used as the format for compiling the NRC criteria applied to the various areas of nuclear safety addressed in a safety analysis report for a nuclear reactor. In each section the criteria are compiled in four groups: (1) Code of Federal Regulations, (2) US NRC Regulatory Guides, SRP Branch Technical Positions and Appendices, (3) Codes and Standards, and (4) Supplemental Information. The degree of application of these criteria to a DOE-owned reactor, consistent with their application to comparable licensed reactors, must be determined by the DOE and DOE contractor

  4. Synthetic Biology for Therapeutic Applications

    OpenAIRE

    Abil, Zhanar; Xiong, Xiong; Zhao, Huimin

    2014-01-01

    Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug d...

  5. 78 FR 2986 - Northern Indiana Public Service Company; Notice of Application for Temporary Variance of License...

    Science.gov (United States)

    2013-01-15

    ... Variance of License Article 403 and Soliciting Comments, Motions to Intervene and Protests Take notice that... inspection: a. Application Type: Extension of temporary variance of license article 403. b. Project No: 12514... Commission to grant an extension of time to a temporary variance of license Article 403 that was granted...

  6. 78 FR 71675 - License Amendment Application for Vermont Yankee Nuclear Power Station

    Science.gov (United States)

    2013-11-29

    ... COMMISSION License Amendment Application for Vermont Yankee Nuclear Power Station AGENCY: Nuclear Regulatory... Operating License No. DPR-28 for the Vermont Yankee Nuclear Power Station, located in Windham County, VT... proposed amendment to Facility Operating License No. DPR-28 for the Vermont Yankee Nuclear Power...

  7. Licensing applications and topical reviews of the RETRAN computer code

    International Nuclear Information System (INIS)

    On September 4, 1984, the US Nuclear Regulatory Commission (NRC) approved, contingent upon completion of correction of errors discovered in the review process, use of RETRAN-02/MOD002 for certain utility applications. Because this generic code review had not included review of plant specific applications, the approval was of the code only, and applicants are required to justify use of the code and its models on a plant and transient specific basis. During and following completion of the generic review, a number of utilities have submitted analyses requesting that the NRC approve the submittals for purposes ranging from simply demonstrating that the applicant was able to use the code, to detailed transient and accident analysis in the licensing arena. The NRC guidance for applicants consists primarily of Generic Letter 83-11 in which an applicant is broadly instructed to perform its own code verification and demonstrate its own technical competence. This broad guidance has led to a wide range of technical detail in submittals and therefore to a correspondingly broad spectrum of NRC approvals. This paper discusses the status of those applications, reviews the breadth of requests and, finally discusses issues that have arisen with respect to these applications

  8. 76 FR 72984 - Revised Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2011-11-28

    ... COMMISSION Revised Application for a License To Export High-Enriched Uranium The application for a license to export high-enriched Uranium has been revised as noted below. Notice of this application was previously... kilograms To fabricate fuel France. Security Complex; October 18, Uranium (93.35%). uranium (174.0...

  9. SIMS applications in biological research

    International Nuclear Information System (INIS)

    Full text: SIMS has been utilised as a tool for biological research since the early 1970's. SIMS' abilities in isotopic detection with high sensitivity, imaging capabilities at a subcellular level, and the possibility of molecular imaging have been the main areas of interest for biological development. However, whilst hundreds of instruments are available in industrial and university laboratories for semiconductor and materials analysis, only a handful successfully perform biological research. For this reason there is generally a lack of awareness of SIMS by the biological community. Biological SIMS analysis requires a working knowledge of both biology and SIMS. Sample preparation is a critical and time consuming prerequisite for any successful biological SIMS study. In addition, for quantification to be possible a homogeneous, matrix matched standard must be available. Once these difficulties are more widely understood and overcome there will be a greater motivation for the biological community to embrace SIMS as a unique tool in their research. This paper provides an overview of some of the more successful biological SIMS application areas internationally, and summarises the types of biological SIMS requests received by ANSTO

  10. Total System Performance Assessment-License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2002-09-13

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issue (KTI) agreements, the ''Yucca Mountain Review Plan'' (CNWRA 2002 [158449]), and 10 CFR Part 63. This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are utilized in this document.

  11. Total System Performance Assessment - License Application Methods and Approach

    International Nuclear Information System (INIS)

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document

  12. License Application Design Selection Report, REV 01. August 1999

    International Nuclear Information System (INIS)

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value as elements of a repository design. In Phase II

  13. License Application Design Selection Report, REV 01. August 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, C.R.

    1999-08-30

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value

  14. 77 FR 21592 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2012-04-10

    ... published in the Federal Register for comment on October 13, 2011 (76 FR 63668). This draft ISG provides... COMMISSION Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes..., ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors: Format...

  15. 76 FR 65544 - Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities

    Science.gov (United States)

    2011-10-21

    ... issuance of the guide (74 FR 36780). The comment period closed on September 21, 2009. The staff's responses... COMMISSION Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities... Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities.'' This...

  16. 76 FR 4417 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2011-01-25

    ... Maritime Administration Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License... Deepwater Port License Application. The application describes an offshore natural gas deepwater port... appeared in the Federal Register on April 11, 2000 (65 FR 19477), see PRIVACY ACT. You may view...

  17. 77 FR 23719 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-20

    ... Type: New NVO License. Bertschi North America Inc. (NVO), 15811 Heatherdale Drive, Houston, TX 77059. Officers: Eloy Ramos, Director/President/Secretary/ Treasurer (Qualifying Individual), Hans J....

  18. 77 FR 16278 - License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear...

    Science.gov (United States)

    2012-03-20

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear Operations, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent...

  19. 78 FR 15747 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Science.gov (United States)

    2013-03-12

    ... Nuclear Engineering (GEH) Licensing Topical Report, NEDC-33178P-A, Revision 1, ``General Electric... features (69 FR 33536; June 16, 2004). Engineering analyses, which may include engineering evaluations....315(c), must be filed in accordance with the NRC's E-Filing rule (72 FR 49139; August 28, 2007). The...

  20. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  1. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    International Nuclear Information System (INIS)

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  2. 76 FR 78702 - Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant...

    Science.gov (United States)

    2011-12-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant, Units 1 and 2) Notice of Atomic Safety and Licensing Board Reconstitution Pursuant to 10 CFR 2.313(c) and 2.321(b), the Atomic Safety and...

  3. Automated License Plate Recognition for Toll Booth Application

    Directory of Open Access Journals (Sweden)

    Ketan S. Shevale

    2014-10-01

    Full Text Available This paper describes the Smart Vehicle Screening System, which can be installed into a tollbooth for automated recognition of vehicle license plate information using a photograph of a vehicle. An automated system could then be implemented to control the payment of fees, parking areas, highways, bridges or tunnels, etc. There are considered an approach to identify vehicle through recognizing of it license plate using image fusion, neural networks and threshold techniques as well as some experimental results to recognize the license plate successfully.

  4. The annotated outlined process for a mined geologic disposal system license application

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is studying Yucca Mountain, Nevada, as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to license the potential repository; if the site is found suitable, a license application would be submitted to the U.S. Nuclear Regulatory Commission (NRC). Current plans are to submit the license application in 2001. To manage development of the license application, DOE has developed the Mined Geologic Disposal System Annotated Outline for License Application (AO). The AO provides a method to verify the site characterization program and to implement the guidance given by the NRC in their draft regulatory guide on the license application. In addition, the AO facilities focused interactions with the NRC and will contribute to the clarification of the regulations. The development of the AO is an interactive process; revisions are produced semiannually, and transmitted to the NRC to provide information and to facilitate NRC's staff guidance to DOE. The AO is an effective method to manage the complex and challenging regulatory and technical information requirements for development of the license application

  5. Total System Performance Assessment - License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2003-12-08

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document.

  6. 78 FR 38336 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-26

    ... Express, LLC (NVO & OFF), 812 Downtowner Blvd., Suite K, Mobile, AL 36609, Officers: Thomas (Mac) H. Mc... License. Magnum-Ramstr Cargo LLC (NVO & OFF), 2 Ethel Road, Suite 202C, Edison, NJ 08817,...

  7. 77 FR 30530 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-23

    .... Interfreight Harmonized Logistics Inc. (NVO & OFF), 221 Sheridan Blvd., Inwood, NY 11096, Officers: Thomas E... NVO License. Ruky International Shipping Line LLC (NVO & OFF), 100 Menlo Park, Suite 310, Edison,...

  8. Automated License Plate Recognition for Toll Booth Application

    OpenAIRE

    Ketan S. Shevale

    2014-01-01

    This paper describes the Smart Vehicle Screening System, which can be installed into a tollbooth for automated recognition of vehicle license plate information using a photograph of a vehicle. An automated system could then be implemented to control the payment of fees, parking areas, highways, bridges or tunnels, etc. There are considered an approach to identify vehicle through recognizing of it license plate using image fusion, neural networks and threshold techniques as wel...

  9. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  10. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    International Nuclear Information System (INIS)

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  11. Environmental Standard Review Plan for the review of license renewal applications for nuclear power plants

    International Nuclear Information System (INIS)

    The Environmental Standard Review Plan for the Review of License Applications for Nuclear Power Plants (ESRP-LR) is to be used by the NRC staff when performing environmental reviews of applications for the renewal of power reactor licenses. The use of the ESRP-LR provides a framework for the staff to determine whether or not environmental issues important to license renewal have been identified and the impacts evaluated and provides acceptance standards to help the reviewers comply with the National Environmental Policy Act

  12. Overview of the earth mounded concrete bunker prototype license application project: Objectives and approach

    Energy Technology Data Exchange (ETDEWEB)

    Conner, J.E. [EG and G Idaho, Inc., Idaho Falls, ID (United States). Idaho National Engineering Lab.

    1989-11-01

    This paper presents an overview of the objectives and approach taken in developing the Earth-mounded Concrete Bunker Prototype License Application Project. The Prototype License Application Project was initiated by the Department of Energy`s National Low-Level Waste Management Program in early 1987 and completed in November 1988. As part of this project a prototype safety analysis report was developed. The safety analysis report evaluates the licensibility of an earth-mounded concrete bunker for a low-level radioactive waste (LLW) disposal facility located on a hypothetical site in the northeastern United States. The project required approximately five person-years and twenty months to develop.

  13. Use of limited information in a license application to construct a repository

    International Nuclear Information System (INIS)

    The purpose of this paper is to provide a rationale for the proposition that the Department of Energy's (DOE's) submittal of a license application (LA) for the construction of a geologic repository to the Nuclear Regulatory Commission (NRC) may be, and arguably must be, based on statutorily-limited site characterization data and design information. The Nuclear Waste Policy Act of 1982 (NWPA), as amended, is the controlling statute for the disposal of spent nuclear fuel in a licensed geologic repository. Applicable NRC regulations for the licensing of such a repository are found for the most part in 10 C.F.R. Part 60

  14. Structural Biology: Practical NMR Applications

    CERN Document Server

    Teng, Quincy

    2005-01-01

    This textbook begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

  15. 21 CFR 515.10 - Medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... Veterinary Medicine home page at http://www.fda.gov/cvm. (b) A completed medicated feed mill license must..., manufacturing, processing, packaging, and holding such animal feeds conform to current good manufacturing... (HFV-220), Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Pl.,...

  16. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-27

    ... telephone at (202) 523-5843 or by email at OTI@fmc.gov . 3PL Logistics, Inc. (NVO), 1401 N. Wood Dale Road... America Cargo International Logistics LLC (NVO & OFF), 5900 NW. 97th Avenue, Unit 1, Miami, FL 33178... License ADN Logistics Group, LLC (OFF), 12030 SW. 129th Court, 103, Miami, FL 33186, Officer: Lourdes...

  17. Removal of Review and Reclassification Procedures for Biological Products Licensed Prior to July 1, 1972. Final rule.

    Science.gov (United States)

    2016-02-12

    The Food and Drug Administration (FDA, the Agency, or we) is removing two regulations that prescribe procedures for FDA's review and classification of biological products licensed before July 1, 1972. FDA is taking this action because the two regulations are obsolete and no longer necessary in light of other statutory and regulatory authorities established since 1972, which allow FDA to evaluate and monitor the safety and effectiveness of all biological products. In addition, other statutory and regulatory authorities authorize FDA to revoke a license for biological products because they are not safe and effective, or are misbranded. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation. PMID:26878738

  18. Biological applications of graphene oxide

    Science.gov (United States)

    Gürel, Hikmet Hakan; Salmankurt, Bahadır

    2016-03-01

    Graphene as a 2D material has unique chemical and electronic properties. Because of its unique physical, chemical, and electronic properties, its interesting shape and size make it a promising nanomaterial in many biological applications. However, the lower water-solubility and the irreversible aggregation due to the strong π-π stacking hinder the wide application of graphene nanosheets in biomedical field. Thus, graphene oxide (GO), one derivative of graphene, has been used more frequently in the biological system owing to its relatively higher water solubility and biocompatibility. Recently, it has been demonstrated that nanomaterials with different functional groups on the surface can be used to bind the drug molecules with high affinity. GO has different functional groups such as H, OH and O on its surface; it can be a potential candidate as a drug carrier. The interactions of biomolecules and graphene like structures are long-ranged and very weak. Development of new techniques is very desirable for design of bioelectronics sensors and devices. In this work, we present first-principles spin polarized calculations within density functional theory to calculate effects of charging on DNA/RNA nucleobases on graphene oxide. It is shown that how modify structural and electronic properties of nucleobases on graphene oxide by applied charging.

  19. 78 FR 64493 - Juneau Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA) and Draft...

    Science.gov (United States)

    2013-10-29

    ... Energy Regulatory Commission Juneau Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA..., 2013. d. Applicant: Juneau Hydropower, Inc. e. Name of Project: Sweetheart Lake Hydroelectric Project.... Applicant Contact: Duff Mitchell, Business Manager, Juneau Hydropower, Inc., P.O. Box 22775, Juneau,...

  20. Application of probabilistic safety analysis to licensing in Japan

    International Nuclear Information System (INIS)

    The safety criteria and standards in Japan are basically deterministic in nature though there are a few probabilistic criteria, even which are given only qualitatively. This does not mean however that quantitative probabilistic argument has not been used in the licensing review process. Three cases can be distinguished where quantitative probabilistic argument plays a major role in the licensing process. They are as follows: (1) exclusion of certain events as residual risk contributors, (2) classification of certain event category among normal operation, anticipated transient and accident, and (3) evaluation of core damage frequency which supports evidences of the adequacy of safe design and safety evaluation. The example of the adoption of these cases in the regulatory process is presented. As is shown in these examples, probabilistic evaluations are more and more used to supplement the deterministic evaluations. However it is cautioned not to rely on the absolute values predicted by the probabilistic safety assessment in the licensing discussion, especially in the case where an extremely small frequency plays a decisive role in the process

  1. Preparing to Submit a License Application for Yucca Mountain

    International Nuclear Information System (INIS)

    In 1982, the U.S. Congress passed the Nuclear Waste Policy Act, a Federal law that established U.S. policy for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Congress amended the Act in 1987, directing the Department of Energy to study only Yucca Mountain, Nevada as the site for a permanent geologic repository. As the law mandated, the Department evaluated Yucca Mountain to determine its suitability as the site for a permanent geologic repository. Decades of scientific studies demonstrated that Yucca Mountain would protect workers, the public, and the environment during the time that a repository would be operating and for tens of thousands of years after closure of the repository. A repository at this remote site would also: preserve the quality of the environment; allow the environmental cleanup of Cold War weapons facilities; provide the nation with additional protection from acts of terrorism; and support a sound energy policy. Throughout the scientific evaluation of Yucca Mountain, there has been no evidence to disqualify Yucca Mountain as a suitable site for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Upon completion of site characterization, the Secretary of Energy considered the results and concluded that a repository at Yucca Mountain would perform in a manner that protects public health and safety. The Secretary recommended the site to the President in February 2002; the President agreed and recommended to Congress that the site be approved. The Governor of Nevada submitted a notice of disapproval, and both houses of Congress acted to override the disapproval. In July 2002, the President's approval allowed the Department to begin the process of submittal of a license application for Yucca Mountain as the site for the nation's first repository for spent nuclear fuel and high-level radioactive waste. Yucca Mountain is located on federal land in Nye County in southern Nevada, an arid region

  2. The contractor`s role in low-level waste disposal facility application review and licensing

    Energy Technology Data Exchange (ETDEWEB)

    Serie, P.J.; Dressen, A.L. [Environmental Issues Management, Inc., Seattle, WA (United States)

    1991-12-31

    The California Department of Health Services will soon reach a licensing decision on the proposed Ward Valley low-level radioactive waste disposal facility. As the first regulatory agency in the country to address the 10 CFR Part 61 requirements for a new disposal facility, California`s program has broken new ground in its approach. Throughout the review process, the Department has relied on contractor support to augment its technical and administrative staff. A team consisting of Roy F. Weston, Inc., supported by ERM-Program Management Corp., Environmental Issues Management, Inc., and Rogers and Associates Engineering Corporation, has worked closely with the Department in a staff extension role. The authors have been involved with the project in contractor project management roles since 1987, and continue to support the Department`s program as it proceeds to finalize its licensing process. This paper describes the selection process used to identify a contractor team with the needed skills and experience, and the makeup of team capabilities. It outlines the management, communication, and technical approaches used to assure a smooth agency-contractor function and relationship. It describes the techniques used to ensure that decisions and documents represented the Department credibly in its role as the regulatory and licensing agency under the Nuclear Regulatory Commission (NRC) Agreement State program. The paper outlines the license application review process and activities, through preparation of licensing documentation and responses to public comments. Lessons learned in coordination of an agency-contractor team effort to review and license a low-level waste disposal facility are reviewed and suggestions made for approaching a similar license application review and licensing situation.

  3. Some applications of understanding of transient fuel failure mechanisms in design and licensing of LMFBRs

    International Nuclear Information System (INIS)

    Some applications of fuel failure technology in reactor design and licensing efforts are discussed. Topics covered include failures in transient overpower accidents, failures in loss-of-flow accidents, off-normal transients, and applications to inherently safe fuel design. (U.S.)

  4. 76 FR 34970 - Avista Corporation; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-06-15

    ... project hydraulic capacity from 23,550 cfs to 24,650 cfs. l. A copy of the application is available for...: Amendment of License. b. Project No.: 2545-148. c. Date Filed: April 15, 2011. d. Applicant: Avista Corporation. e. Name of Project: Spokane River Project. f. Location: The project is located on the...

  5. 77 FR 63301 - Juneau Hydropower, Inc.; Notice of Draft License Application and Preliminary Draft Environmental...

    Science.gov (United States)

    2012-10-16

    ... Energy Regulatory Commission Juneau Hydropower, Inc.; Notice of Draft License Application and Preliminary...: August 31, 2012. d. Applicant: Juneau Hydropower, Inc. e. Name of Project: Sweetheart Lake Hydroelectric... Hydropower, Inc., P.O. Box 22775, Juneau, AK 99802; 907-789-2775, email: duff.mitchell@juneauhydro.com ....

  6. 33 CFR 211.9 - Applications for leases, easements, licenses, and permits.

    Science.gov (United States)

    2010-07-01

    ... WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.9 Applications for leases, easements, licenses, and permits. Applications for use of Civil Works property should be made to the District Engineer of the district within the boundaries of which the real estate is located....

  7. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z., E-mail: jonatasfmata@yahoo.com.br, E-mail: vasconv@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  8. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    International Nuclear Information System (INIS)

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  9. Information to be submitted in support of licensing applications for nuclear power plants

    International Nuclear Information System (INIS)

    This Safety Guide was prepared as part of the Agency's programme, referred to as the NUSS programme, for establishing Codes of Practice and Safety Guides relating to nuclear power plants. It supplements the Agency's Safety Series No.50-C-G, entitled ''Governmental Organization for the Regulation of Nuclear Power Plants: A Code of Practice''. It is concerned with the content of documents which should be submitted to the regulatory body by the applicant/licensee in support of licensing applications, with a possible method of classifying these documents and with the scheduling of their submission to the regulatory body at each major stage of the licensing process

  10. 76 FR 16420 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-03-23

    ... Logistics Officer (Qualifying Individual), Jack R. Lentz, CEO/Chairman/ Secretary, Application Type: New NVO... (Qualifying Individual), Kazuo Ishizuka, President/CEO, Application Type: Business Structure Change and...

  11. 78 FR 73566 - Standard Format and Content for a License Application for an Independent Spent Fuel Storage...

    Science.gov (United States)

    2013-12-06

    ... COMMISSION Standard Format and Content for a License Application for an Independent Spent Fuel Storage... Application for an Independent Spent Fuel Storage Installation or a Monitored Retrievable Storage Facility... Josh Goshen, Licensing Branch, Division of Spent Fuel Storage and Transportation, Office of...

  12. 77 FR 35079 - License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC

    Science.gov (United States)

    2012-06-12

    ... COMMISSION License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent to prepare supplement to draft ] supplemental environmental impact statement. SUMMARY: On May 25, 2010, NextEra Energy Seabrook, LLC...

  13. 78 FR 45578 - Application For a License to Export Radioactive Waste

    Science.gov (United States)

    2013-07-29

    ... COMMISSION Application For a License to Export Radioactive Waste Pursuant to 10 CFR 110.70 (b) ``Public... electronically through ADAMS and can be accessed through the Public Electronic Reading Room (PERR) link http... electronic filing, at least 5 (five) days prior to the filing deadline, the petitioner/requestor...

  14. 77 FR 73054 - Application for a License To Export Radioactive Waste

    Science.gov (United States)

    2012-12-07

    ... COMMISSION Application for a License To Export Radioactive Waste Pursuant to 10 CFR 110.70(b) ``Public Notice... through ADAMS and can be accessed through the Public Electronic Reading Room (PERR) link http://www.nrc... public Web site at http://www.nrc.gov/site-help/e-submittals.html . To ensure timely electronic...

  15. 77 FR 14445 - Application for a License To Export Steel Forging

    Science.gov (United States)

    2012-03-09

    ... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC's public... COMMISSION Application for a License To Export Steel Forging Pursuant to 10 CFR 110.70(b) ``Public Notice of... Spain. December 15, 2011 head steel head steel February 7, 2012 forging. forging will be XR175...

  16. Standard format and content of license applications for plutonium processing and fuel fabrication plants

    International Nuclear Information System (INIS)

    The standard format suggested for use in applications for licenses to possess and use special nuclear materials in Pu processing and fuel fabrication plants is presented. It covers general description of the plant, summary safety assessment, site characteristics, principal design criteria, plant design, process systems, waste confinement and management, radiation protection, accident safety analysis, conduct of operations, operating controls and limits, and quality assurance

  17. 75 FR 6223 - Application For a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-08

    ... COMMISSION Application For a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fabricate Canada. Complex December 21, 2009, Uranium (93.35%). uranium (16.3 targets for December 28, 2009... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on timely...

  18. 75 FR 7525 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fuel France; Belgium. Security Complex, February 2, Uranium (93.35%). uranium (87.3 elements in...

  19. 75 FR 15743 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-03-30

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149.36 elements in March 9, 2010... FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the NRC's...

  20. 78 FR 33448 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2013-06-04

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... targets Canada. Security Complex, May 13, Uranium (93.35%). uranium-235 at the National 2013, May 21, 2013, XSNM3745, contained in 7.5 Research Universal 11006098. kilograms reactor in Canada for uranium....

  1. 76 FR 59173 - Standard Format and Content of License Applications for Conventional Uranium Mills

    Science.gov (United States)

    2011-09-23

    ... COMMISSION Standard Format and Content of License Applications for Conventional Uranium Mills AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; withdrawal. SUMMARY: On May 30, 2008 (73 FR 31152... Conventional Uranium Mills.'' DG- 3024 was a proposed Revision 2 of Regulatory Guide (RG) 3.5. However,...

  2. 77 FR 1956 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-01-12

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(b) ``Public... Netherlands. Security Complex. Uranium uranium (9.3 targets at December 21, 2011 (93.35%). kilograms U- CERCA... August 2007, 72 FR 49139 (Aug. 28, 2007). Information about filing electronically is available on the...

  3. 77 FR 51579 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-08-24

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... kilograms For the export of Canada. Complex, July 30, 2012, August Uranium (93.35%). uranium-235 high-enriched 1, 2012, XSNM3726, 11006037. contained in 7.5 uranium in the kilograms uranium. form of...

  4. 77 FR 73055 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... kilograms To fabricate targets The Netherlands. Security Complex. Uranium uranium-235 at CERCA AREVA October... XSNM3730 uranium. targets at the HFR 11006054 Research Reactor in the Netherlands, the BR-2 Reactor...

  5. 77 FR 73056 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70 (b) ``Public... targets Belgium. Security Complex. Uranium (93.2%). uranium-235 at CERCA AREVA Romans October 10, 2012 contained in 6.2 in France and to October 12, 2012 kilograms irradiate targets at XSNM3729 uranium. the...

  6. Partnering with Industry to Deliver Continuing Education to Florida's Licensed Pesticide Applicators

    Science.gov (United States)

    Fishel, Fred

    2014-01-01

    Partnering with private industry can empower Extension educators to enhance their educational outreach efforts. Since 2011, UF/IFAS has cooperated with the Florida Turfgrass Association in conducting a 1-day statewide Polycom® event for providing continuing education to licensed pesticide applicators employed primarily in the ornamental and…

  7. 77 FR 73632 - American Municipal Power, Inc; Notice of Application for Temporary Variance of License and...

    Science.gov (United States)

    2012-12-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission American Municipal Power, Inc; Notice of Application for Temporary Variance of License and Soliciting Comments, Motions To Intervene, and Protests Take notice that the...

  8. 78 FR 37878 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-24

    ... (LNG) Deepwater Port appears in the Federal Register on June 14, 2013, 78 FR 36014. The ``Summary of... of Transportation Privacy Act Notice that appeared in the Federal Register on April 11, 2000 (65 FR... Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose...

  9. 78 FR 41190 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-07-09

    ... Operations, telephone 202-366-9826. Correction In the Federal Register of June 24, 2013, in FR Doc. 2013-0363... Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port AGENCY: Maritime Administration, Department of Transportation. ACTION: Notice of intent; notice...

  10. 78 FR 42588 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-07-16

    ... the Federal Register of June 24, 2013, in FR Doc. 2013-0363, on page 37878, in the second column... TRANSPORTATION Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port AGENCY: Maritime Administration, Department of Transportation. ACTION: Notice of...

  11. 76 FR 39922 - Notice of Acceptance of Application for Special Nuclear Materials License From Sensor Concepts...

    Science.gov (United States)

    2011-07-07

    ... participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August...\\ Requesters should note that the filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28, 2007... COMMISSION Notice of Acceptance of Application for Special Nuclear Materials License From Sensor Concepts...

  12. 78 FR 51753 - AUC, LLC Reno Creek, In Situ Project, New Source Material License Application

    Science.gov (United States)

    2013-08-21

    ...), and opportunity to request a hearing was published in the Federal Register on August 5, 2013 (78 FR... opportunity to request a hearing was published in the Federal Register on August 5, 2013 (73 FR 47427). The... COMMISSION AUC, LLC Reno Creek, In Situ Project, New Source Material License Application AGENCY:...

  13. 78 FR 37324 - Preparation of Environmental Reports for Nuclear Power Plant License Renewal Applications

    Science.gov (United States)

    2013-06-20

    ... COMMISSION 10 CFR Parts 51 and 54 RIN 3150-AI42 Preparation of Environmental Reports for Nuclear Power Plant..., Supplement 1 (RG 4.2S1), ``Preparation of Environmental Reports for Nuclear Power Plant License Renewal... reports that are submitted with the application for the renewal of a nuclear power plant operating...

  14. NEP Nuclear Power Plant, Units 1 and 2. License application, general and financial information

    International Nuclear Information System (INIS)

    A license application is presented for 2 pressurized water reactors at a proposed location in Charlestown RI. Each reactor will have a net capacity of 1150 MW. Cooling water will be supplied by the Atlantic Ocean. NEP-1 is scheduled for operation in 1983 and NEP-2 in 1985

  15. 75 FR 70350 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2010-11-17

    ... Maritime Administration Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License.... Coast Guard received an application from Liberty Natural Gas LLC for all Federal authorizations required... the transportation, storage, and further handling of oil or natural gas for transportation to...

  16. Pesticide Applicator Profiling: Using Polycom[R] Distance Delivery for Continuing Education and Characterizing Florida's Licensed Applicators

    Science.gov (United States)

    Fishel, Fred; Langeland, Ken

    2011-01-01

    The University of Florida offers continuing education units (CEUs) via distance technology using Polycom[R] to meet requirements for applicators of pesticides to renew their licenses. A large statewide event conducted in 2010 also included a needs assessment of this group concerning CEUs. Results indicate that these applicators strongly prefer…

  17. 77 FR 62500 - John B. Crockett; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-10-15

    ... Federal Energy Regulatory Commission John B. Crockett; Notice of Intent To File License Application.... b. Project No.: 14355-001. c. Dated Filed: September 4, 2012. d. Submitted By: John B. Crockett. e... Pursuant to: 18 CFR 5.3 of the Commission's regulations. h. Potential Applicant Contact: John B....

  18. 77 FR 6552 - Mahoning Hydropower, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-02-08

    ... Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Intent To File License Application.... b. Project No.: P-13954-001. c. Date Filed: December 7, 2011. d. Submitted By: Mahoning Hydropower.... Potential Applicant Contact: Anthony Marra, Mahoning Hydropower, LLC, 11365 Normandy Lane, Chagrin Falls,...

  19. NPP long term operation in Spain - First application for license renewal

    International Nuclear Information System (INIS)

    Full text: In the operation of the Spanish nuclear power plants (NPP), safety is always the prime consideration. Plant Life Management Programmes have been set up with the strategic objective to operate the NPPs as long as they are considered safe and reliable. The safety of each NPP is reviewed by the Spanish nuclear regulatory authority (CSN) under a continuous process. In addition, experience is gained from operating the plants and from exchanges with operators of similar units. Current Spanish regulatory framework for renewing NPP operating licenses requires performing a Periodic Safety Review (PSR) to be performed every 10 years and submitted when applying for a new renewal of the NPP operating license. A few years ago, CSN issued a document regarding the licensing requirements that nuclear power plants should meet in order to be granted with an operating license for long term operation (i.e, operation beyond the original plant design life, typically 40 years). Besides the traditional PSR requirements, specific requirements regarding to long term operation (LTO) include: - An Aging Management and Evaluation Program, including the identification and evaluation of Time Limited Aging Analysis (TLAA). - An updated Radiological Impact Study. - A review and assessment of regulation/standard applicability. Garona NPP (GE, BWR/3 design) operated by Spanish utility Nuclenor from 1971 has a current operating license up to 2009. A decision was made to apply for a new operating license, being Garona plant the first one in Spain to face with the new long term operation requirements. The paper will provide an overview of the methodology used in Spain to address and perform the required analyses to support the LTO application for the operating license renewal. In particular, focus will be paid on the project developed in Garona (2002-2006) whose result has been the first Spanish application for License Renewal for LTO. Also it will be reported the ongoing work necessary to

  20. 76 FR 62407 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-07

    ... 30326, Officers: Chad Rosenberg, President/CEO (Qualifying Individual), Michael Shea, Secretary..., Officers: Alexandre Ayanou, Manager/President/CEO (Qualifying Individual), Faty Ayanou, Member, Application... Brodecki, Chairman, Application Type: QI Change. Crowley Logistics, Inc. (NVO & OFF), 9487 Regency...

  1. 77 FR 28880 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-05-16

    .../Manager/CEO, Application Type: QI Change/Trade Name Change. Lone Star Integrated Distribution, LLC dba H.B.... Choi, CEO/President/Secretary, Application Type: QI Change. Rockin Boxes Global, Inc. (NVO & OFF...: Jeffrey R. Landa, President (Qualifying Individual), Warren P. Powers, Chairman, Application Type:...

  2. 78 FR 55698 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-11

    ..., Suite F, Smyrna, GA 30082, Officers:, Simon J. Button, CEO (QI), Dave Tighe, CFO, Application Type: QI...), Yanzhong Ding, President, Application Type: QI Change. Harvest Logistics, LLC (NVO & OFF), 2441 Porter..., NY 11354, Officers: Leo Chiu, Vice President (QI), Ting F. Yeung, President, Application Type:...

  3. 76 FR 67188 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-10-31

    ..., Doral, FL ] 33126, Officers: Ramiro M. Ramirez, Jr., Vice President/Director, (Qualifying Individual), Mirna Ramirez, President/Secretary/Treasurer/ Director, Application Type: Add OFF Service....

  4. 75 FR 48686 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-11

    ... York, NY 10001, Officer: Neal M. Rosenberg, President (Qualifying Individual), Application Type: Remove... 10001, Officers: Neal M. Rosenberg, Member/Manager (Qualifying Individual), Joshua Rosenberg,...

  5. 77 FR 32115 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-05-31

    ... (Qualifying Individual), Marika Georgakopoulos, Secretary, Application Type: QI Change. EZ Forwarding LLC (NVO... Marine Services, Inc. dba Inchcape Shipping Services (NVO & OFF), 11 N. Water Street, 9290, Mobile,...

  6. 76 FR 22104 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-20

    .../Treasurer/CFO (Qualifying Individual), Shangen (Garrisun)Ge, President/CEO/Director, Application Type: New..., (Qualifying Individual), Harrison Cutler, Chairman, Application Type: Trade Name Change Den Helder Inc. (NVO & OFF), 35E 42nd Street, A1, Bayonne, NJ 07002, Officers: Salil Parkar, Director/CEO...

  7. 75 FR 66099 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-10-27

    ... & Import Service (Qualifying Individual), Joseph L. Carnes, Chairman and CEO, Application Type: Name Change... American Shipping, LLC (NVO), 10564 Progress Way, Suite E, Cypress, CA 90630, Officers: Paul D. Snell, CEO... Para, CEO, Application Type: QI Change. De Well Logistics LLC dba De Well Logistics, dba De Well...

  8. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-06

    .... Officers: Gayton J. Thomas, CEO (QI), Abdullah W. Alsawi, President, Application Type: QI Change. Global..., Dominguez Hills, CA 90220. Officers: Yuji Inoue, Executive Vice President (QI), Hideaki Suzuki, Chairman.... Officers: Jeffrey M. Bumgardner, Senior Vice President (QI), Larry Wu, CEO, Application Type: New NVO &...

  9. 75 FR 37805 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2010-06-30

    .... Lorrie Vidal, CEO (Qualifying Individual). Application Type: New OFF & NVO. Alisped U.S.A. Inc. (NVO... President (Qualifying Individual), Harrison Cutler, Chairman. Application Type: QI Change. Demanko HLC... LLC (NVO), 25 E. Spring Valley Avenue--Suite 100, Maywood, NJ 07607. Joseph Monaghan,...

  10. 77 FR 50688 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-08-22

    ..., NC 28211. Officers: Brian W. Taylor, Chairman (Qualifying Individual), Michael F. Zendan, II...), Rosemary Marr, CEO. Application Type: Name Change to C. H. Robinson Project Logistics, Inc. Vilkon N.A..., CEO (Qualifying Individual), Youngeui Kim, CFO. Application Type: QI Change. By the Commission....

  11. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry. PMID:23502560

  12. 75 FR 51074 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-18

    ..., President, (Qualifying Individual), Application Type: Add Trade Name. CLA Investment & Development, Inc. dba CLA Shipping, Inc., (NVO & OFF), 129 S. 8th Avenue, C, La Puente, CA 91746. Officers: Hong...

  13. 76 FR 44330 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-25

    ..., Seattle, WA 98188, Officers: Charles K. Behrens, President, (Qualifying Individual), Todd L. Halverson..., (Qualifying Individual), David P. Kratt, President, Application Type: QI Change. Direct Freight Services LLC..., Jamaica, NY 11434, Officers: Harjinder P. Singh, President/Chief Executive Manager, (Qualifying...

  14. 76 FR 6135 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-03

    ... Service. Global Way International, Inc. (NVO), 17756 Palo Verde Avenue, Cerritos, CA 90703, Officer: James... & Marketing, Application Type: QI Change. Outer Seaways, Inc. (NVO), 1315 Walnut Street, 1708A,...

  15. 75 FR 20997 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-04-22

    ..., Inc. (OFF & NVO), 2315 NW 107th, 1M-28, Doral, FL 33172. Officers: Virginie M. Guerra-Mondragon, Secretary/Treasurer, (Qualifying Individual). Andres R. Guerra-Mondragon, CEO, Application Type: QI...

  16. Biological and Geographical application tool

    OpenAIRE

    Pereira, Miguel

    2007-01-01

    Monitoring and species identify is an essential step to natural resources management. Among these, biological resources aim special concern because data availability is highly limited by a number of sampling logistic constraints and catalog. As a matter of fact, data availability is one of important limitation to knowledge and, as a consequence the development of a new concept in natural resources. Data organization in digital format is a common practice in our days, and has the power to cont...

  17. 78 FR 30914 - Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-05-23

    ... Variance of License and Soliciting Comments, Motions To Intervene and Protests Take notice that the... inspection: a. Application Type: Temporary variance of license. b. Project No.: 1494-416. c. Date Filed... of Request: Grand River Dam Authority (GRDA) requests a temporary variance, for the year 2013,...

  18. 75 FR 39667 - Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent Application

    Science.gov (United States)

    2010-07-12

    ... Department of the Army Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent... availability for licensing of the invention set forth in U.S. Patent Application Serial No. 12/149,076, entitled ``Combinations of Gene Deletions for Live Attenuated Shigella Vaccine Strains,'' filed April...

  19. 77 FR 59389 - Hawks Nest Hydro, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-09-27

    ... Energy Regulatory Commission Hawks Nest Hydro, LLC; Notice of Intent To File License Application, Filing...: Hawks Nest Hydro, LLC. e. Name of Project: Hawks Nest Hydroelectric Project (P-2512-069) and Glen Ferris Hydroelectric Project (P-14439-000) f. Location: Hawks Nest Hydroelectric Project is on the New River in...

  20. Spin labels. Applications in biology

    International Nuclear Information System (INIS)

    The main applications of spin labels in the study of biomembranes, enzymes, nucleic acids, in pharmacology, spin immunoassay are reviewed along with the fundamentals of the spin label method. 137 references. (author)

  1. 10 CFR 40.31 - Application for specific licenses.

    Science.gov (United States)

    2010-01-01

    ... determined pursuant to subpart A of part 51 of this chapter will significantly affect the quality of the... in order to enable the Commission to determine whether the application should be granted or denied or... requirements under the Emergency Planning and Community Right-to-Know Act of 1986, Title III. Pub. L. 99-499...

  2. Barnwell Nuclear Fuel Plant. License application, amendment 10

    International Nuclear Information System (INIS)

    Amendment No. 10 provides the applicant's responses to questions raised by the AEC in letters dated November 6 and December 5, 1974. Amendment No. 3, dated February 1975, to the BNFP Separations Facility Final Safety Analysis Report (FSAR) is included. The amendment consists of revision pages for volumes 1 through 5 of the FSAR along with a deletion and insertion guide. (U.S.)

  3. 76 FR 71034 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-16

    .... Versant Supply Chain, Inc. (NVO & OFF), 4105 S. Mendenhall, Memphis, TN 38115. Officers: Kim Verna... OTI@fmc.gov . AAB Global Logistics, LLC (NVO & OFF), 201 E. Dundee Road, 2, Palatine, IL 60074.... Application Type: Name Change. Abco International Freight (USA) Inc. dba Abco Logistics (NVO), 9420...

  4. 78 FR 43202 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-07-19

    ...), 8000 NW 29th Street, Miami, FL 33122, Officers: Adrian Martinez, Operations Manager (QI), Jose G. Suarez, Sales Manager, Application Type: QI Change. UBA Express Cargo, Corp. (NVO), 10350 West Flagler..., Suite 6, Miami, FL 33178, Officers: Paul Selvage, Member (QI), Steven Periman,...

  5. The regulatory review of construction license application and the supporting safety case

    International Nuclear Information System (INIS)

    Finland is one of the foremost countries in the world in developing the disposal of spent fuel. The construction license application for the Olkiluoto spent fuel disposal facility was submitted to the authorities at the end of 2012 and the facility is expected to start operation around 2020. This has been a long-term project with over 30 years of parallel development of the repository project and the regulatory approach to spent fuel management. In 1983 the government made a strategic decision on the objectives and target time schedule for the research, development and technical planning of nuclear waste management. While an export and international disposal solution was still the preferred option, this decision required the licensees without this possibility to prepare for disposal in Finland and it also gave the time line for the milestones on the way to an operating disposal facility by 2020. The licensing procedure for a disposal facility has several steps that are similar to all nuclear facilities in Finland and are defined in Nuclear Energy Act and Decree (1987, 1988). These licensing steps are: - Decision-in-principle is required for a nuclear facility having considerable general significance. This is essentially a political decision: the government decides if the construction project is in line with the overall good of society. The decision can be applied for one or more sites, the host municipality has a veto right and the parliament has the choice of ratifying or not ratifying the decision. - Construction license is granted by the government and authorises the construction of the disposal facility. The actual construction is regulated by STUK and includes several review and approval steps, hold points and viewpoints. - Operational license is granted by the government and authorises the operation of the facility for a certain period. The operational license is needed before nuclear waste can be disposed. The first step in the licensing process was reached

  6. Aptamers and Their Biological Applications

    Directory of Open Access Journals (Sweden)

    Changill Ban

    2012-01-01

    Full Text Available Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-based selection methods, are explained in detail. We also introduce various applications of aptamers for the diagnosis of diseases and detection of small molecules. Numerous analytical techniques, such as electrochemical, colorimetric, optical, and mass-sensitive methods, can be utilized to detect targets, due to convenient modifications and the stability of aptamers. Finally, several medical and analytical applications of aptamers are presented. In summary, aptamers are promising materials for diverse areas, not just as alternatives to antibodies, but as the core components of medical and analytical equipment.

  7. Safety evaluation review of the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the belowground vault (BGV) alternative method of low-level radioactive waste disposal. In Volume 1 of NUREG-1375, the NRC staff provided the safety review results for an earth-mounded concrete bunker PLASAR. In the current report, the staff focused its review on the design, construction, and operational aspects of the BGV PLASAR. The staff developed review comments and questions using the Standard Review Plan (SRP), Rev. 1 (NUREG-1200) as the basis for evaluating the acceptability of the information provided in the BGV PLASAR. The detailed review comments provided in this report are intended to be useful guidance to facility developers and State regulators in addressing issues likely to be encountered in the review of a license application for a low-level-waste disposal facility. 44 refs

  8. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    International Nuclear Information System (INIS)

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  9. Palo Verde Generating Station, Units 4 and 5. License application, general information

    International Nuclear Information System (INIS)

    A license application for two more Palo Verde reactors, Units 4 and 5, is presented. The two PWR reactors have a nominal net generating power each of 1,270 MW(e). Containments are steel-lined prestressed cylindrical structures with hemispherical domes. The reactors are replicas of Palo Verde 1, 2 and 3 (see DOCKETS 50528, 50529 and 50530) using the standard Combustion Engineering System 80 (see DOCKET-STN-50470)

  10. Aptamers and Their Biological Applications

    OpenAIRE

    Changill Ban; Seonghwan Lee; Kyung-Mi Song

    2012-01-01

    Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-ba...

  11. Strategic Basis for License Application Planning for a Potential Yucca Mountain Repository

    International Nuclear Information System (INIS)

    If Yucca Mountain, Nevada is designated as the site for development of a geologic repository for disposal of spent nuclear fuel and high-level radioactive waste, the Department of Energy (DOE) must obtain Nuclear Regulatory Commission (NRC) approval first for repository construction, then for an operating license, and, eventually, for repository closure and decommissioning. The licensing criteria defined in Code of Federal Regulations, Title 10, Part 63 (10 CFR Part 63) establish the basis for these NRC decisions. Submittal of a license application (LA) to the NRC for authorization to construct a repository at the Yucca Mountain site is, at this point, only a potential future action by the DOE. The policy process defined in the Nuclear Waste Policy Act (NWPA), as amended, for recommendation and designation of Yucca Mountain as a repository site makes it difficult to predict whether or when the site might be designated. The DOE may only submit a LA to the NRC if the site designation takes effect. In spite of this uncertainty, the DOE must take prudent and appropriate action now, and over the next several years, to prepare for development and timely submittal of a LA. This is particularly true given the need for the DOE to develop, load, and certify the operation of its electronic information system to provide access to its relevant records as part of the licensing support network (LSN) in compliance with NRC requirements six months prior to LA submittal. The DOE must also develop a LA, which is a substantially different document from those developed to support a Site Recommendation (SR) decision. The LA must satisfy NRC licensing criteria and content requirements, and address the acceptance criteria defined by the NRC in its forthcoming Yucca Mountain Review Plan (YMRP). The content of the LA must be adequate to facilitate NRC acceptance and docketing for review, and the LA and its supporting documents must provide the documented basis for the NR C findings required

  12. Single nanoparticle detectors for biological applications

    Science.gov (United States)

    Yurt, Abdulkadir; Daaboul, George G.; Connor, John H.; Goldberg, Bennett B.; Selim Ünlü, M.

    2012-01-01

    Nanoparticle research has become increasingly important in the context of bioscience and biotechnology. Practical use of nanoparticles in biology has significantly advanced our understanding about biological processes in the nanoscale as well as led to many novel diagnostic and therapeutic applications. Besides, synthetic and natural nanoparticles are of concern for their potential adverse effect on human health. Development of novel detection and characterization tools for nanoparticles will impact a broad range of disciplines in biological research from nanomedicine to nanotoxicology. In this article, we discuss the recent progress and future directions in the area of single nanoparticle detectors with an emphasis on their biological applications. A brief critical overview of electrical and mechanical detection techniques is given and a more in-depth discussion of label-free optical detection techniques is presented.

  13. 75 FR 29335 - Rumford Falls Hydro, LLC; Notice of Application for Amendment of License, and Soliciting Comments...

    Science.gov (United States)

    2010-05-25

    ... inspection: a. Type of Application: Amendment of License. b. Project No.: 2333-068. c. Date Filed: July 23... site located at http://ferc.gov .filing-comments.asp. Please include the project number (P-...

  14. Mammalian synthetic biology: emerging medical applications

    OpenAIRE

    Kis, Zoltán; Pereira, Hugo Sant'Ana; Homma, Takayuki; Pedrigi, Ryan M.; Krams, Rob

    2015-01-01

    In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and tog...

  15. Quantum metrology and its application in biology

    Science.gov (United States)

    Taylor, Michael A.; Bowen, Warwick P.

    2016-02-01

    Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artefacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient details to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science. We hope that this will aid in bridging the communication gap that exists

  16. Marine Carotenoids: Biological Functions and Commercial Applications

    OpenAIRE

    Vega, José M.; Inés Garbayo; Francisco Bédmar; María Cuaresma; Carlos Vílchez; Eduardo Forján

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesised by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functions of carotenoids relevant for life on earth. Biological properties of carotenoids allow for wide range of commercial applications. Indeed, recent interest in the carotenoids has be...

  17. Single nanoparticle detectors for biological applications

    OpenAIRE

    Yurt, Abdulkadir; Daaboul, George G.; Connor, John H.; Goldberg, Bennett B.; Ünlü, M. Selim

    2012-01-01

    Nanoparticle research has become increasingly important in the context of bioscience and biotechnology. Practical use of nanoparticles in biology has significantly advanced our understanding about biological processes in the nanoscale as well as led to many novel diagnostic and therapeutic applications. Besides, synthetic and natural nanoparticles are of concern for their potential adverse effect on human health. Development of novel detection and characterization tools for nanoparticles will...

  18. Biological and Biomedical Coatings Handbook Applications

    CERN Document Server

    Zhang, Sam

    2011-01-01

    Written in a versatile, contemporary style that will benefit both novice and expert alike, Biological and Biomedical Coatings Handbook, Two-Volume Set covers the state of the art in the development and implementation of advanced thin films and coatings in the biological field. Consisting of two volumes--Processing and Characterization and Applications--this handbook details the latest understanding of advances in the design and performance of biological and biomedical coatings, covering a vast array of material types, including bio-ceramics, polymers, glass, chitosan, and nanomaterials. Contri

  19. Biological applications of nanoscale materials

    Science.gov (United States)

    Liang, Chi-Hui

    2007-12-01

    The objective of my research work is to synthesize, characterize, design, and apply nanocrystals for biomedical use. Gold nanoparticles were synthesized in the presence of chitosan via reduction of HAuCl4 with sodium borohydride. The average particle size of gold nanoparticles was significantly affected with the concentration of chitosan added and was ranged between 5 and 30 nm. The gold-chitosan nanocomposites were formed by adsorbing chitosan molecules on the gold nanoparticles. CdSe/ZnS quantum dots were prepared by a solution phase synthetic method. A new route for the phase transfer of CdSe/ZnS quantum dots from non-polar solvents into aqueous solution was developed using hydrophobically modified polysaccharides, both chitosan and alginate. In addition, it was shown that CdSe/ZnS based polysaccharide nanoparticles effectively inhibited the proliferation of human ovarian cancer cell line SKOV-3 in vitro. The findings suggest that CdSe/ZnS quantum dot based polysaccharide nanoparticles not only act as a long-term biomarker but also have potential value in cancer therapy. A novel method for extracting magnetite nanoparticles from magnetotactic bacteria was developed by using co-surfactant. The problem of mass cultivation was solved by growing AMB-1 in Ca2+-alginate microbeads. To apply magnetotactic bacterial in biomedical applications, uptake of chitosan-capped CdSe/ZnS quantum dots on magnetotactic bacteria and introducing fluorescent magnetotactic bacteria into mouse macrophage cells was achieved. A general strategy is described which allows for constructing multifunctional magnetic nanocomposites based on bacterial magnetite nanoparticles. Specifically, core-shell structures of bacterial magnetite-CdSe ZnS and bacterial magnetite-gold nanocomplexes have been built in this way. Furthermore, design and synthesis multimodal contrast agents which are ultrasound and photoacoustic active are achieved by utilizing biocompatible gold nanorods self assembling on

  20. Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and...

  1. 76 FR 81992 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2011-12-29

    ... COMMISSION PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption 1.0..., Certifications, and Approvals for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend Nuclear... application is based upon the U.S. EPR reference COL (RCOL) application for UniStar's Calvert Cliffs...

  2. Radio-analysis. Applications: biological dosimetry

    International Nuclear Information System (INIS)

    Radioisotopes have revolutionized the medical biology. Radio-immunology remains the reference measurement of the infinitely small in biology. Constant efforts have been performed to improve the simpleness, detectability and fastness of the method thanks to an increasing automation. This paper presents: 1 - the advantages of compounds labelling and the isotopic dilution; 2 - the antigen-antibody system: properties, determination of the affinity constant using the Scatchard method; 3 - radio-immunologic dosimetry: competitive dosimetry (radioimmunoassay), calibration curve and mathematical data processing, application to the free thyroxine dosimetry, immunoradiometric dosimetry (immunoradiometric assay), evaluation of the analytical efficiency of a radioimmunoassay; 4 - detection of the radioactive signal (solid and liquid scintillation). (J.S.)

  3. Format and content for the license application for the high-level waste repository

    International Nuclear Information System (INIS)

    The purpose of this regulatory guide, ''Format and Content for the License Application for the High-Level Waste Repository,'' is to indicate the information to be provided in the LA and to establish a format acceptable to the NRC staff for presenting the information. Use of this format will help ensure the completeness of the information provided, will assist the NRC staff and others in locating the information, and will shorten the time needed for the review process. This guide is being issued as a draft to afford DOE, government agencies, and members of the public an opportunity to submit comments on the guide

  4. Model tracking system for low-level radioactive waste disposal facilities: License application interrogatories and responses

    International Nuclear Information System (INIS)

    This report describes a model tracking system for a low-level radioactive waste (LLW) disposal facility license application. In particular, the model tracks interrogatories (questions, requests for information, comments) and responses. A set of requirements and desired features for the model tracking system was developed, including required structure and computer screens. Nine tracking systems were then reviewed against the model system requirements and only two were found to meet all requirements. Using Kepner-Tregoe decision analysis, a model tracking system was selected

  5. Porphyrin Microparticles for Biological and Biomedical Applications

    Science.gov (United States)

    Huynh, Elizabeth

    Lipids are one of the critical building blocks of life, forming the plasma membrane of cells. In addition, porphyrins also play an equally important role in life, for example, through carrying oxygen in blood. The importance of both these components is evident through the biological and biomedical applications of supramolecular structures generated from lipids and porphyrins. This thesis investigates new porphyrin microparticles based on porphyrin-lipid architecture and their potential applications in biology and medicine. In Chapter 1, a background on lipid and porphyrin-based supramolecular structures is presented and design considerations for generating multifunctional agents. Chapter 2 describes the generation of a monolayer porphyrin microparticle as a dual-modal ultrasound and photoacoustic contrast agent and subsequently, a trimodal ultrasound, photoacoustic and fluorescence contrast agent. Chapter 3 examines the optical and morphological response of these multimodality ultrasound-based contrast agents to low frequency, high duty cycle ultrasound that causes the porphyrin microparticles to convertinto nanoparticles. Chapter 4 examines the generation of bilayer micrometer-sized porphyrin vesicles and their properties. Chapter 5 presents a brief summary and potential future directions. Although these microscale structures are similar in structure, the applications of these structures greatly differ with potential applications in biology and also imaging and therapy of disease. This thesis aims to explore and demonstrate the potential of new simplified, supramolecular structures based on one main building block, porphyrin-lipid.

  6. Shaping Biological Knowledge: Applications in Proteomics

    Directory of Open Access Journals (Sweden)

    R. Appel

    2006-04-01

    Full Text Available The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa and a hypothesis-driven (focus on whole bacterial proteomes approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  7. Molecular biology applications to infectious diseases diagnostic

    International Nuclear Information System (INIS)

    This project goes directed to the applications of the techniques of molecular biology in hepatitis virus.A great advance of these techniques it allows its application to the diagnose molecular and it becomes indispensable to have these fundamental tools in the field of the Health Public for the detection precocious, pursuit of the treatment, the one predicts and the evolution of the patient hepatitis bearing virus technical.Use of molecular biology to increase the handling and the control of the patients with hepatitis B and C and to detect an adult numbers of positive cases by means of the training and integration of all the countries participating.Implement the technique of PCR to identify the virus of the hepatitis B and C,implement quantification methods and genotipification for these virus

  8. Nanotechnology Applications for Chemical and Biological Sensors

    Directory of Open Access Journals (Sweden)

    M. K. Patra

    2008-09-01

    Full Text Available Recent discoveries indicate that when the materials are brought down to sizes in the range 1–100 nm, theseexhibit unique electrical, optical, magnetic, chemical, and mechanical properties. Methods have now beenestablished to obtain the monodisperse nanocrystals of various metallic and semiconducting materials, single-walled and multi-walled nanotubes of carbon and other metallic and non-metallic materials together withorganic nanomaterials such as supra-molecular nanostructures, dendrimers, hybrid composites with tailoredfunctionalities. The high surface-to-volume ratio with an added element of porosity makes these highly potentialcandidates for chemical and biological sensor applications with higher degree of sensitivity and selectivity ascompared to their bulk counterparts. The paper reviews the recent developments and applications of chemicaland biological sensors based on nanomaterials of various structural forms.Defence Science Journal, 2008, 58(5, pp.636-649, DOI:http://dx.doi.org/10.14429/dsj.58.1686

  9. Preparing as an organization to review a construction license application for a DGR for HLW and SF in the USA

    International Nuclear Information System (INIS)

    Although formally opposed by the State of Nevada, the Yucca Mountain site (Nevada) recommendation was approved by the U.S. Congress and the President, which authorized DOE to prepare and submit a license application for a deep geologic repository for the nation's spent nuclear fuel and high-level waste. In June of 2008, DOE submitted this application to the U.S. Nuclear Regulatory Commission (NRC) for its review and formal adjudication of contested issues during a 3-4 year period. Although subsequent actions by the Administration and Congress have changed the direction for geologic disposal in the U.S., the NRC staff was able to conduct a thorough technical review of the DOE license application and issue technical evaluation reports before the review and hearings were suspended in September 2011. This paper provides the author's perspective on how the NRC prepared for, and conducted, this first-of-a-kind licensing review: planning framework, key preparations for staff and for processes, events after the receipt of a license application, retrospective on staff preparations and on processes. By the end of September 2011, the NRC staff had issued three Technical Evaluation Reports using a risk-informed, performance-based approach to review the DOE license application for this deep geologic repository at Yucca Mountain

  10. Machine Learning for Biological Trajectory Classification Applications

    Science.gov (United States)

    Sbalzarini, Ivo F.; Theriot, Julie; Koumoutsakos, Petros

    2002-01-01

    Machine-learning techniques, including clustering algorithms, support vector machines and hidden Markov models, are applied to the task of classifying trajectories of moving keratocyte cells. The different algorithms axe compared to each other as well as to expert and non-expert test persons, using concepts from signal-detection theory. The algorithms performed very well as compared to humans, suggesting a robust tool for trajectory classification in biological applications.

  11. Application of nanotechnology in biology and promising application in radiobiology

    International Nuclear Information System (INIS)

    As one of the 21-Century high and new technologies, nanotechnology (NT) has been widely applied in all aspects of biology. From now on, it has been used for detecting substance, carrying drug, antibacterial and tumour therapy by its photometric characteristics, mechanics characteristics, thermal property and other characteristics. Because of the unique advantages of nanoparticles, nanotechnology has great potential in radioprotection. In this article, we introduced the application of nanotechnology in modern biology and the primal problems. Meantime, we explain the prospect of its application in radioprotection. (authors)

  12. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  13. 76 FR 40904 - FPL Energy Maine Hydro LLC; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2011-07-12

    ... project's installed capacity from 83.7 MW to 85.2 MW and the hydraulic capacity would increase by 2.5... Application: Amendment of License. b. Project No: 2329-089. c. Date Filed: June 3, 2011. d. Applicant: FPL Energy Maine Hydro LLC. e. Name of Project: Wyman Project. f. Location: The project is located on...

  14. 78 FR 69402 - Lock 7 Hydro Partners, LLC; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2013-11-19

    .... Application Type: Amendment of License. b. Project No: 539-013. c. Date Filed: September 23, 2013. d. Applicant: Lock 7 Hydro Partners, LLC. e. Name of Project: Mother Ann Lee Hydroelectric Project. ] f... generating unit No. 2. The runner replacement would increase the installed and hydraulic capacities of...

  15. Gibbs and Hill Standard Safety Analysis Report, GIBBSSAR. License application, volume 1: chapters 1--3 (section 7)

    International Nuclear Information System (INIS)

    License application for the GIBBSSAR Standard Plant is presented. The reactor used with the GIBBSSAR balance-of-plant system is the Westinghouse 3800 MW(t) PWR. This portion of the application includes a general plant description; site characteristics; and design of structures, components, equipment and systems

  16. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Science.gov (United States)

    2013-03-06

    ... Energy Regulatory Commission Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower, LLC (transferee) filed an application for transfer of...

  17. 78 FR 4465 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2013-01-22

    ... COMMISSION PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption 1.0... Approvals for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend Nuclear Power Plant... (RCOL) application for UniStar's Calvert Cliffs Nuclear Power Plant, Unit 3 (CCNPP3). The NRC...

  18. 78 FR 14842 - Crystal River Nuclear Generating Plant, Unit 3; Application for Renewal of License to Facility...

    Science.gov (United States)

    2013-03-07

    ... application in the Federal Register on March 9, 2009 (74 FR 10099). The FPC requested withdrawal of the... renewal, which was published in the Federal Register on June 3, 2011 (76 FR 32237). However, since the... COMMISSION Crystal River Nuclear Generating Plant, Unit 3; Application for Renewal of License to...

  19. Biological Properties and Therapeutic Applications of Propolis.

    Science.gov (United States)

    Sforcin, José M

    2016-06-01

    Propolis is a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen and wax. In this review, the biological properties of propolis and some therapeutic applications are discussed. The same biological activities have been investigated until today, using samples from different geographic regions. Thus, the study of the biological properties of a given sample should always be associated with its chemical composition and botanical source, representing a particular sample of a given geographic area, exploring its biological potential and the role of its constituents. Efforts have been carried out to explain propolis' mechanisms of action in vivo and in vitro, but the majority of propolis' targets and actions are still unclear. The number of formulations containing propolis and patents have increased, although propolis extracts have been used deliberately with different recommendations, not always mentioning the chemical composition, vegetal source and the methods of extraction. Clinical studies will help to obtain criterious recommendations in view of the expected outcomes. Further investigation should explore the effects of common compounds found in the samples from all over the world in an attempt to standardize the research on propolis and to obtain new drugs. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26988443

  20. Biological basis of beam application in biotechnology

    International Nuclear Information System (INIS)

    Heavy particle beams have relatively high value of linear energy transfer (LET), and relative biological effectiveness (RBE). There is a sharp increase in ionization density (LET) in the so-called Bragg peak, close to the end of each track. The LET and RBE may, therefore, be high at the distal edge of the biological target volume. It is well-known that as the LET is increased beyond about 30 keV/um the RBE increases to a peak at 100 to 110 keV/um and then falls. At the same time the oxygen-enhancement ratio (OER) decreases steadily. The reason of these events has a greater chance per unit dose of depositing a certain minimum energy of about 300 eV, that is, 10 to 15 ionizations into each biological target volume of 5 to 10 nm diameter. These biological targets may be pictured as double strands of DNA and histones, 2 or 3 nm in diameter, with a surrounding water sheath of a few nm thick. The drop of RBE with increasing LET past the peak of RBE is due to either overkill or the recombinations of electrons and ions and of chemical radicals in the higher LET track. Large new accelerators have allowed the effects of heavy particle irradiation to be investigated. In biotechnology, radiation methods have found application as tools to explore some basic problems and this aspect of radiation research is likely to expand in the future. (author)

  1. 21 CFR 610.53 - Dating periods for licensed biological products.

    Science.gov (United States)

    2010-04-01

    ... years 5 years. Blood Group Substance AB ......do ......do 2 years. Blood Group Substance A ......do ......do Do. Blood Group Substance B ......do ......do Do. Botulism Antitoxin ......do Not applicable 5... blood cells ......do ......do Do. 3. Enzyme conjugated products ......do ......do Do. Iodinated...

  2. Repository program licensing approach

    International Nuclear Information System (INIS)

    Yucca Mountain, Nevada is currently being studied by the US Department of Energy (DOE) as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to determine the suitability of the site and to develop a license application (LA) for authorization to construct the potential repository. If the site is suitable, the license application would be submitted to the US Nuclear Regulatory Commission (NRC). The repository program licensing approach is focused on the timely acquisition of information needed in licensing and the resolution of potential licensing issues with the NRC staff. Licensing involves an iterative process requiring refinements as data are acquired, analyzed, and evaluated. The repository licensing approach presented in this paper ensures that the information is available when needed to facilitate the licensing process. Identifying the information needed to evaluate compliance with the performance objectives in 10 CFR 60, monitoring the acquisition of such information, and developing a successful license application are integral elements of DOE's repository program licensing approach. Activities to characterize the site are being systematically conducted as planned in the Site Characterization Plan (SCP). In addition, DOE is implementing the issue resolution initiative, the license application annotated outline (LAAO) process, and interim licensability evaluations to update the early planning in the SCP and to focus site characterization, design, and performance assessment activities on the acquisition of information needed for a site suitability determination and licensing. Collectively, the issue resolution initiative, LAAO process, and interim licensability evaluations are key elements of a transition to the iterative process to answer the question: open-quotes When do we have enough data to support licensing?close quotes

  3. Safety evaluation status report for the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the earth-mounded concrete bunker (EMCB) alternative method of low-level radioactive waste disposal. The NRC reviewers relied extensively on the Standard Review Plan (SRP), Rev.1 (NUREG-1200), to evaluate the acceptability of the information provided in the EMCB PLASAR. The NRC staff selected certain review areas in the PLASAR for development of safety evaluation report input to provide examples of safety assessments that are necessary as part of a licensing review. Because of the fictitious nature of the assumed disposal site, and the decision to limit the review to essentially first-round review status, the NRC staff report is labeled a ''Safety Evaluation Status Report'' (SESR). Appendix A comprises the NRC review comments and questions on the information that DOE submitted in the PLASAR. The NRC concentrated its review on the design and operations-related portions of the EMCB PLASAR

  4. Screening Analysis of Criticality Features, Events, and Processes for License Application

    International Nuclear Information System (INIS)

    This report documents the screening analysis of postclosure criticality features, events, and processes. It addresses the probability of criticality events resulting from degradation processes as well as disruptive events (i.e., seismic, rock fall, and igneous). Probability evaluations are performed utilizing the configuration generator described in ''Configuration Generator Model'', a component of the methodology from ''Disposal Criticality Analysis Methodology Topical Report''. The total probability per package of criticality is compared against the regulatory probability criterion for inclusion of events established in 10 CFR 63.114(d) (consider only events that have at least one chance in 10,000 of occurring over 10,000 years). The total probability of criticality accounts for the evaluation of identified potential critical configurations of all baselined commercial and U.S. Department of Energy spent nuclear fuel waste form and waste package combinations, both internal and external to the waste packages. This criticality screening analysis utilizes available information for the 21-Pressurized Water Reactor Absorber Plate, 12-Pressurized Water Reactor Absorber Plate, 44-Boiling Water Reactor Absorber Plate, 24-Boiling Water Reactor Absorber Plate, and the 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Short waste package types. Where defensible, assumptions have been made for the evaluation of the following waste package types in order to perform a complete criticality screening analysis: 21-Pressurized Water Reactor Control Rod, 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Long, and 2-Multi-Canister Overpack/2-Defense High-Level Radioactive Waste package types. The inputs used to establish probabilities for this analysis report are based on information and data generated for the Total System Performance Assessment for the License Application, where available. This analysis report determines whether criticality is to be

  5. Guide for the preparation of applications for licenses for the use of radioactive materials in servicing preregistered gauges, measuring devices, and sealed sources used in such devices. Draft

    International Nuclear Information System (INIS)

    The purpose of this regulatory guide is to provide assistance to applicants and licensees in preparing applications for new licenses, license amendments, and license renewals. This guide describes the information the NRC staff needs to evaluate an application for a license for the use of radioactive materials in certain commercial services for other NRC or Agreement State licensees. The services covered by this guide are the installation, relocation, maintenance, repair, and performance of the initial radiation survey of preregistered gauging or measuring devices containing licensed material and leak tests, installation, replacement, and disposal of sealed sources used in such devices. This guide also covers other essential services, as appropriate, such as training customer personnel on the radiation safety aspects of the use of the devices and on NRC regulatory requirements as they pertain to the customer's licensed devices. This regulatory guide is intended to provide the applicant or licensee with information that will enable him to understand specific regulatory requirements and licensing policies as they apply to the specified services that he provides. The information in this guide is not a substitute for training in radiation safety. After being issued a license, the program must be conducted in accordance with (1) the statements, representations, and procedures contained in your application, (2) the terms and conditions of the license, and (3) the Nuclear Regulatory Commission's regulations. The information provided in the application should be clear, specific, and accurate

  6. PIXE and its applications to biological samples

    International Nuclear Information System (INIS)

    Throughout this century, industrialized society has seriously affected the ecology by introducing huge amounts of pollutants into the atmosphere as well as marine and soil environments. On the other hand, it is known that these pollutants, in excess of certain levels of concentration, not only put at risk the life of living beings but may also cause the extinction of some species. It is therefore of basic importance to substantially increase quantitative determinations of trace element concentrations in biological specimens in order to assess the effects of pollutants. It is in this field that PIXE plays a key role in these studies, where its unique analytical properties are decisive. Moreover, since the importance of these research has been recognized in many countries, many scientists have been encouraged to continue or initiate new research programmes aimed to solve the worldwide pollution problem. This document presents an overview of those papers reporting the application of PIXE analysis to biological samples during this last decade of the 20th century and recounts the number of PIXE laboratories dedicating their efforts to find the clues of the biological effects of the presence of pollutants introduced in living beings. Sample preparation methods, different kinds of samples under study and the use of complementary analytical techniques are also illustrated. (author). 108 refs

  7. Radio-analysis. Applications: biological dosimetry; Radioanalyse. Applications: dosage biologique

    Energy Technology Data Exchange (ETDEWEB)

    Bourrel, F. [CEA Saclay, INSTN, Institut National des Sciences et Techniques Nucleaires, 91 - Gif-sur-Yvette (France); Courriere, Ph. [UFR de Pharmacie, 31 - Toulouse (France)

    2003-06-01

    Radioisotopes have revolutionized the medical biology. Radio-immunology remains the reference measurement of the infinitely small in biology. Constant efforts have been performed to improve the simpleness, detectability and fastness of the method thanks to an increasing automation. This paper presents: 1 - the advantages of compounds labelling and the isotopic dilution; 2 - the antigen-antibody system: properties, determination of the affinity constant using the Scatchard method; 3 - radio-immunologic dosimetry: competitive dosimetry (radioimmunoassay), calibration curve and mathematical data processing, application to the free thyroxine dosimetry, immunoradiometric dosimetry (immunoradiometric assay), evaluation of the analytical efficiency of a radioimmunoassay; 4 - detection of the radioactive signal (solid and liquid scintillation). (J.S.)

  8. Contrast media: Biologic effects and clinical application

    International Nuclear Information System (INIS)

    An overview is presented of the recent developments in contrast media and their clinical applications, plus the current state-of-the-art in computerized tomography, digital subtraction angiography, ultrasound and magnetic resonance imaging (MRI). Contents of these volumes include: an in-depth review of the historical development, modern perspectives in structure-function relationships, biologic effects on hemostats, gastrointestinal, cardiovascular systems and drug interactions. Critical and basic issues, including cellular toxicity, mutagenesis, synergism between radiation and contrast agents, mechanisms in contrast-induced reactions, and the management of such reactions in high-risk patients are also presented. Specific applications of paramagnetic compounds in MRI and the recent concept of liposome-encapsulated and particulate suspension of contrast materials in diagnostic imaging are thoroughly discussed

  9. Contrast media: Biologic effects and clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Parvez, Z.; Moncada, R.; Sovak, M.

    1987-01-01

    An overview is presented of the recent developments in contrast media and their clinical applications, plus the current state-of-the-art in computerized tomography, digital subtraction angiography, ultrasound and magnetic resonance imaging (MRI). Contents of these volumes include: an in-depth review of the historical development, modern perspectives in structure-function relationships, biologic effects on hemostats, gastrointestinal, cardiovascular systems and drug interactions. Critical and basic issues, including cellular toxicity, mutagenesis, synergism between radiation and contrast agents, mechanisms in contrast-induced reactions, and the management of such reactions in high-risk patients are also presented. Specific applications of paramagnetic compounds in MRI and the recent concept of liposome-encapsulated and particulate suspension of contrast materials in diagnostic imaging are thoroughly discussed.

  10. Current regulatory and licensing status for byproduct sources, facilities and applications

    Energy Technology Data Exchange (ETDEWEB)

    Tingey, G.L.; Jensen, G.A.; Hazelton, R.F.

    1985-02-01

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig.

  11. Current regulatory and licensing status for byproduct sources, facilities and applications

    International Nuclear Information System (INIS)

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig

  12. 75 FR 39668 - Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-07-12

    ..., revocable license for the field of shigella vaccine development to U.S. Patent Application No. 11/727,486 entitled ``Artificial Invaplex,'' filed March 27, 2007, and related foreign patent applications (PCT/US2007... Department of the Army Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned...

  13. 76 FR 38177 - Falcon Shipping Inc., Abdiel Falcon-Application for a License as an Ocean Transportation...

    Science.gov (United States)

    2011-06-29

    ... Falcon Shipping Inc., Abdiel Falcon--Application for a License as an Ocean Transportation Intermediary Order To Show Cause Falcon Shipping Inc. (Falcon Shipping) and Mr. Abdiel Falcon submitted an...) on March 8, 2011. Incorporated in Florida on February 18, 2008, Falcon Shipping is currently...

  14. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-04-18

    ... Federal Energy Regulatory Commission Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License... Friends Fund XXX, LLC. e. Name of Project: New Cumberland Locks and Dam Hydroelectric Project. f. Location... Commission's regulations. h. Potential Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends...

  15. 78 FR 4467 - UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3...

    Science.gov (United States)

    2013-01-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3, Exemption 1.0 Background UniStar Nuclear Energy (UNE), on behalf of Calvert Cliffs Nuclear Project, LLC and UniStar Nuclear Operating Services,...

  16. 76 FR 81994 - UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit...

    Science.gov (United States)

    2011-12-29

    ... COMMISSION UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit 3; Exemption 1.0 Background: UniStar Nuclear Energy (UNE) submitted to the U.S. Nuclear Regulatory... in a violation of the Atomic Energy Act of 1954, as amended, or the NRC's regulations. Therefore,...

  17. Applicability of IBAMA normative instruction 146-2007 to pipeline environmental licensing

    Energy Technology Data Exchange (ETDEWEB)

    Basbaum, Marcos A.; Fonseca, Renata A.A. [Servicos de Engenharia Emilio Baumgart Ltda. (SEEBLA), Rio de Janeiro, RJ(Brazil)], e-mail: mbasbaum.seebla@petrobras.com.br, e-mail: renataamorim.seebla@petrobras.com.br; Torggler, Bianca F.; Fernandes, Renato; Guimaraes, Ricardo Z.P. [Petroleo do Brasil S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)], e-mail: torggler@petrobras.com.br, e-mail: renatofer@petrobras.com.br, e-mail: rzaluar@petrobras.com.br

    2009-07-01

    PETROBRAS has been conducting several wildlife programs in response to environmental licensing requirements from IBAMA (Brazilian environmental agency). Since 2007, IBAMA has been requiring the application of the Normative Instruction n. 146 (NI), which establishes criteria for wildlife management in the influence areas of new enterprises. However, experience from PETROBRAS has shown that many of the NI articles are not applicable to pipelines. Thus, a critical analysis of this NI was done based on data from company's wildlife programs. Our analysis indicated that the main NI items that do not apply to pipelines are: 1 - Animal rescue programs in deforested areas and selection of release areas, 2 - More than two fauna monitoring campaigns a year, 3 - Monitoring programs involving all groups of terrestrial vertebrates and also invertebrate classes. The non-applicability of these items is due to: 1 - The majority of pipelines are built in areas without significant native vegetation or with small fragments only, which are usually in secondary stage of ecological succession. Most pipelines scarcely involve removal of primary vegetation, 2 - Pipelines have an influence area restricted to a range of 800 m and the construction directly affects only strips from 20 m to 30 m, 3 - The most relevant impacts associated with pipelines are temporary, and do not persist during their operation. (author)

  18. Application of Graph Coloring to Biological Networks

    CERN Document Server

    Khor, Susan

    2009-01-01

    We explore the application of graph coloring to biological networks, specifically protein-protein interaction (PPI) networks. First, we find that given similar conditions (i.e. number of nodes, number of links, degree distribution and clustering), fewer colors are needed to color disassortative (high degree nodes tend to connect to low degree nodes and vice versa) than assortative networks. Fewer colors create fewer independent sets which in turn imply higher concurrency potential for a network. Since PPI networks tend to be disassortative, we suggest that in addition to functional specificity and stability proposed previously by Maslov and Sneppen (Science 296, 2002), the disassortative nature of PPI networks may promote the ability of cells to perform multiple, crucial and functionally diverse tasks concurrently. Second, since graph coloring is closely related to the presence of cliques in a graph, the significance of node coloring information to the problem of identifying protein complexes, i.e. dense subg...

  19. Oligothiophenes as Fluorescent Markers for Biological Applications

    Directory of Open Access Journals (Sweden)

    Antonio Manetto

    2012-01-01

    Full Text Available This paper summarizes some of our results on the application of oligothiophenes as fluorescent markers for biological studies. The oligomers of thiophene, widely known for their semiconductor properties in organic electronics, are also fluorescent compounds characterized by chemical and optical stability, high absorbance and quantum yield. Their fluorescent emission can be easily modulated via organic synthesis by changing the number of thiophene rings and the nature of side-chains. This review shows how oligothiophenes can be derivatized with active groups such as phosphoramidite, N-hydroxysuccinimidyl and 4-sulfotetrafluorophenyl esters, isothiocyanate and azide by which the (biomolecules of interest can be covalently bound. This paper also describes how molecules such as oligonucleotides, proteins and even nanoparticles, tagged with oligothiophenes, can be used in experiments ranging from hybridization studies to imaging of fixed and living cells. Finally, a few multilabeling experiments are described.

  20. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  1. Graphene for Environmental and Biological Applications

    Science.gov (United States)

    Sreeprasad, T. S.; Pradeep, T.

    2012-08-01

    The latest addition to the nanocarbon family, graphene, has been proclaimed to be the material of the century. Its peculiar band structure, extraordinary thermal and electronic conductance and room temperature quantum Hall effect have all been used for various applications in diverse fields ranging from catalysis to electronics. The difficulty to synthesize graphene in bulk quantities was a limiting factor of it being utilized in several fields. Advent of chemical processes and self-assembly approaches for the synthesis of graphene analogues have opened-up new avenues for graphene based materials. The high surface area and rich abundance of functional groups present make chemically synthesized graphene (generally known as graphene oxide (GO) and reduced graphene oxide (RGO) or chemically converted graphene) an attracting candidate in biotechnology and environmental remediation. By functionalizing graphene with specific molecules, the properties of graphene can be tuned to suite applications such as sensing, drug delivery or cellular imaging. Graphene with its high surface area can act as a good adsorbent for pollutant removal. Graphene either alone or in combination with other materials can be used for the degradation or removal of a large variety of contaminants through several methods. In this review some of the relevant efforts undertaken to utilize graphene in biology, sensing and water purification are described. Most recent efforts have been given precedence over older works, although certain specific important examples of the past are also mentioned.

  2. Biological fuel cells and their applications

    OpenAIRE

    Shukla, AK; Suresh, P; Berchmans, S; Rajendran, A.

    2004-01-01

    One type of genuine fuel cell that does hold promise in the long-term is the biological fuel cell. Unlike conventional fuel cells, which employ hydrogen, ethanol and methanol as fuel, biological fuel cells use organic products produced by metabolic processes or use organic electron donors utilized in the growth processes as fuels for current generation. A distinctive feature of biological fuel cells is that the electrode reactions are controlled by biocatalysts, i.e. the biological redox-reac...

  3. How a regulator is preparing for reviewing a license application file: The case of ASN

    International Nuclear Information System (INIS)

    The French Nuclear Safety Authority (ASN) is an independent administrative authority. It prepares regulation pertaining to the management of radioactive waste, monitors the control of safety of basic nuclear installations that produce or treat waste or are involved in their disposal and performs inspections of waste producers (EDF, AREVA, CEA, hospitals, research centres, etc.) and Andra, the French National Radioactive Waste Management Agency. It regulates the overall system set up by Andra for accepting waste from producers and assesses waste management policy and the practices of radioactive waste producers. It reviews license applications and authorises commissioning of nuclear installations. In order to review technical documents, ASN benefits from the expertise of technical support organisations. The French Institute for Radiation Protection and Nuclear Safety (IRSN) is the main such organisation. ASN has been making efforts to diversify its experts for several years. In preparing its decisions, ASN also calls on the opinions and recommendations of seven Advisory Committees of Experts (GPE), with expert knowledge in the areas of waste, nuclear pressure equipment, medical exposure, non-medical radiation protection, reactors, transport, and laboratories and nuclear plants. ASN consults the GPEs in preparing its main decisions. In particular, they review the preliminary, provisional and final safety analysis reports for each nuclear installation. They can also be consulted about changes in regulations or doctrine. (authors)

  4. Development of RESRAD probabilistic computer codes for NRC decommissioning and license termination applications

    International Nuclear Information System (INIS)

    In 1999, the US Nuclear Regulatory Commission (NRC) tasked Argonne National Laboratory to modify the existing RESRAD and RESRAD-BUILD codes to perform probabilistic, site-specific dose analysis for use with the NRC's Standard Review Plan for demonstrating compliance with the license termination rule. The RESRAD codes have been developed by Argonne to support the US Department of Energy's (DOEs) cleanup efforts. Through more than a decade of application, the codes already have established a large user base in the nation and a rigorous QA support. The primary objectives of the NRC task are to: (1) extend the codes' capabilities to include probabilistic analysis, and (2) develop parameter distribution functions and perform probabilistic analysis with the codes. The new codes also contain user-friendly features specially designed with graphic-user interface. In October 2000, the revised RESRAD (version 6.0) and RESRAD-BUILD (version 3.0), together with the user's guide and relevant parameter information, have been developed and are made available to the general public via the Internet for use

  5. FCC Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and...

  6. Detector applications in medecine and biology

    CERN Document Server

    Del Guerra, Alberto

    1995-01-01

    In recent years new diagnostic and therapeutic methods have been attracting more and more dedicated attention by the scientific community.The goal is a better understanding of the anatomy, physiology and pathology of the human being in an effort to find more appropriate medical prevention, diagnosis and therapy.Many of the achievements obtained so far derive from the use and the optimisation of detectors and techniques,which originated in the other fields of physics. The spin-off of High Energy Physics to Medical Physics has been particularly relevant in the field of detectors for medical imaging and especially for medical imaging with ionizing radiation. In this series of lectures,starting from the requests of each technique and or application I will attempt to present a survey of the detectors for medecine and biology. Various fields of medical imaging will be touched : radiology,digital radiography,mammography and radiotherapy. The capabilities of the major types of detectors (1-D and 2-D position sensitiv...

  7. Application of graph colouring to biological networks.

    Science.gov (United States)

    Khor, S

    2010-05-01

    The author explores the application of graph colouring to biological networks, specifically protein-protein interaction (PPI) networks. First, the author finds that given similar conditions (i.e. graph size, degree distribution and clustering), fewer colours are needed to colour disassortative than assortative networks. Fewer colours create fewer independent sets which in turn imply higher concurrency potential for a network. Since PPI networks tend to be disassortative, the author suggests that in addition to functional specificity and stability proposed previously by Maslov and Sneppen (Science, 296, 2002), the disassortative nature of PPI networks may promote the ability of cells to perform multiple, crucial and functionally diverse tasks concurrently. Second, because graph colouring is closely related to the presence of cliques in a graph, the significance of node colouring information to the problem of identifying protein complexes (dense subgraphs in PPI networks), is investigated. The author finds that for PPI networks where 1-11% of nodes participate in at least one identified protein complex, such as H. sapien, DSATUR (a well-known complete graph colouring algorithm) node colouring information can improve the quality (homogeneity and separation) of initial candidate complexes. This finding may help improve existing protein complex detection methods, and/or suggest new methods. [Includes supplementary material]. PMID:20499999

  8. Neutron Scattering in Biology Techniques and Applications

    CERN Document Server

    Fitter, Jörg; Katsaras, John

    2006-01-01

    The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

  9. Applications in computer-assisted biology

    NARCIS (Netherlands)

    Nijveen, H.

    2013-01-01

    Biology is becoming a data-rich science driven by the development of high-throughput technologies like next-generation DNA sequencing. This is fundamentally changing biological research. The genome sequences of many species are becoming available, as well as the genetic variation within a species, a

  10. Nuclear microscopy technology and applications in biology

    International Nuclear Information System (INIS)

    The thesis comprises both technical descriptions of the microprobes used as well as applications in biology consisting of tracer element measurements using PIXE analysis. An older nuclear microprobe was transferred to the EN-tandem accelerator at the The Svedberg Laboratory in Uppsala and used until it was degraded and replaced. The design and development of a the new scanning light ion microprobe in Uppsala, Slim-Up, is described. The Slim-Up is equipped with three magnetic quadrupole lenses of outstanding quality. Together with computerised magnetic beem steering, magnetic beam scanning, target imaging and data acquisition they form the central parts for a trace element analysis system with a spatial resolution in the micrometer range. Tracer element distributions in fresh water mussel shells have been measured in several annual layers. This was done in order to monitor the status, and any changes, in the elemental composition of the environment during the life times of the mussels. The transport of lead from mother to preembryos has been investigated in mice. After an intravenous injection of lead chloride, in mice in experimental delay of implantation, the blastocysts were taken out and the lead concentration measured. In non-insulin-dependent diabetes mellitus the insulin release from the β-cells in the islets of Langerhans, is affected by exhaustion. Mouse pancreas has been used for determination of the distribution of some elements in β-cells in correlation with exhaustion caused by starvation and insulin release. Protective effects of selenium against mercury and cadmium toxicity were studied in a rat model. In addition to the observed protective effects of selenium, zinc was proven to give some protection against lead toxicity. (au)

  11. Facilities license application record data as of April 1, 1981. Tri-annual report 30 Nov 80-1 Apr 81

    International Nuclear Information System (INIS)

    The FLAR is divided into three parts as follows: Part I - The first part is a listing of all operating licenses, authorizations and construction permits in effect plus applications pending; Part II - The second part is a listing of applications that have been withdrawn or denied, and licenses and construction permits terminated or revoked; and Part III - The third part is a listing of research, test and power reactors for export

  12. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  13. 78 FR 35273 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

    Science.gov (United States)

    2013-06-12

    ... new biological products contain data that are adequate to assess the safety and effectiveness of the... and advertisements for biological products as well as for prescription drugs and antibiotics. The... Service Act (42 U.S.C. 262), manufacturers of biological products must submit a license application...

  14. Structural Biology and Molecular Applications Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research and development in this area focuses on enabling technologies, models, and methodologies to support basic and applied cancer research.

  15. Proceedings of biological applications of relativistic nuclei

    International Nuclear Information System (INIS)

    The workshop BARN 92 on various aspects of radiation treatment of tumours and of biological radiation effects on living system hosted 38 short papers. Each is indexed and abstracted separately for the INIS database. (R.P.)

  16. OpenCV在车牌识别中的应用%Application of OpenCV in License Plate Recognition

    Institute of Scientific and Technical Information of China (English)

    姜莉莉; 蒋潇; 陈昕怡; 殷旭东

    2014-01-01

    For license plate recognition on smart phone, application of OpenCV is studied. First, OpenCV and work flow of license plate recognition are introduced. Then detailed application of OpenCV is discussed, which is in license plate location, character segmentation and character recognition. Experimental results show that the recognition is good. The foundation is laid for further developing a vehicle information management system on smart phones such as Android.%为利用智能手机进行车牌识别,研究了OpenCV在车牌识别中的应用。首先介绍了OpenCV及车牌识别的工作流程,然后论述了OpenCV在车牌定位、字符分割和字符识别中的具体应用。实验结果表明识别效果良好,为在Android等智能手机上进一步开发车辆信息管理系统奠定了基础。

  17. ITER licensing

    International Nuclear Information System (INIS)

    ITER was fortunate to have four countries interested in ITER siting to the point where licensing discussions were initiated. This experience uncovered the challenges of licensing a first of a kind, fusion machine under different licensing regimes and helped prepare the way for the site specific licensing process. These initial steps in licensing ITER have allowed for refining the safety case and provide confidence that the design and safety approach will be licensable. With site-specific licensing underway, the necessary regulatory submissions have been defined and are well on the way to being completed. Of course, there is still work to be done and details to be sorted out. However, the informal international discussions to bring both the proponent and regulatory authority up to a common level of understanding have laid the foundation for a licensing process that should proceed smoothly. This paper provides observations from the perspective of the International Team. (author)

  18. Synthetic Biology: Applications in the Food Sector.

    Science.gov (United States)

    Tyagi, Ashish; Kumar, Ashwani; Aparna, S V; Mallappa, Rashmi H; Grover, Sunita; Batish, Virender Kumar

    2016-08-17

    Synthetic biology also termed as "genomic alchemy" represents a powerful area of science that is based on the convergence of biological sciences with systems engineering. It has been fittingly described as "moving from reading the genetic code to writing it" as it focuses on building, modeling, designing and fabricating novel biological systems using customized gene components that result in artificially created genetic circuitry. The scientifically compelling idea of the technological manipulation of life has been advocated since long time. Realization of this idea has gained momentum with development of high speed automation and the falling cost of gene sequencing and synthesis following the completion of the human genome project. Synthetic biology will certainly be instrumental in shaping the development of varying areas ranging from biomedicine, biopharmaceuticals, chemical production, food and dairy quality monitoring, packaging, and storage of food and dairy products, bioremediation and bioenergy production, etc. However, potential dangers of using synthetic life forms have to be acknowledged and adoption of policies by the scientific community to ensure safe practice while making important advancements in the ever expanding field of synthetic biology is to be fully supported and implemented. PMID:25365334

  19. Biological nanostructures and applications of nanostructures in biology electrical, mechanical, and optical properties

    CERN Document Server

    Stroscio, Michael A

    2004-01-01

    Biological Nanostructures and Applications of Nanostructures in Biology: Electrical, Mechanical, and Optical Properties contains reviews and discussions of contemporary and relevant topics dealing with the interface between the science and technology of nanostructures and the science of biology. Moreover, this book supplements these past groundbreaking discoveries with discussions of promising new avenues of research that reveal the enormous potential of emerging approaches in nanobiotechnology. The topics include: This state-of-the-art survey of key developments in nanotechnology - as they ap

  20. Exploiting for medical and biological applications

    Science.gov (United States)

    Giano, Michael C.

    Biotherapeutics are an emerging class of drug composed of molecules ranging in sizes from peptides to large proteins. Due to their poor stability and mucosal membrane permeability, biotherapeutics are administered by a parenteral method (i.e., syringe, intravenous or intramuscular). Therapeutics delivered systemically often experience short half-lives. While, local administration may involve invasive surgical procedures and suffer from poor retention at the site of application. To compensate, the patient receives frequent doses of highly concentrated therapeutic. Unfortunately, the off-target side effects and discomfort associated with multiple injections results in poor patient compliance. Therefore, new delivery methods which can improve therapeutic retention, reduce the frequency of administration and may aid in decreasing the off-target side effects is a necessity. Hydrogels are a class of biomaterials that are gaining interests for tissue engineering and drug delivery applications. Hydrogel materials are defined as porous, 3-dimensional networks that are primarily composed of water. Generally, they are mechanically rigid, cytocompatible and easily chemically functionalized. Collectively, these properties make hydrogels fantastic candidates to perform as drug delivery depots. Current hydrogel delivery systems physically entrap the target therapeutic which is then subsequently released over time at the site of administration. The swelling and degradation of the material effect the diffusion of the therapy from the hydrogel, and therefore should be controlled. Although these strategies provide some regulation over therapeutic release, full control of the delivery is not achieved. Newer approaches are focused on designing hydrogels that exploit known interactions, covalently attach the therapy or respond to an external stimulus in an effort to gain improved control over the therapy's release. Unfortunately, the biotherapeutic is typically required to be chemically

  1. Hidden Markov processes theory and applications to biology

    CERN Document Server

    Vidyasagar, M

    2014-01-01

    This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. The book starts from first principles, so that no previous knowledge of probability is necessary. However, the work is rigorous and mathematical, making it useful to engineers and mathematicians, even those not interested in biological applications. A range of exercises is provided, including drills to familiarize the reader with concepts and more advanced problems that require deep thinking about the theory. Biological applications are t

  2. 76 FR 54753 - Whitestone Power and Communications; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2011-09-02

    ...-kilowatt turbine/ generator unit; (4) a 33-foot-long, 3.5-foot-wide gangway from the shore to the floating... Energy Regulatory Commission Whitestone Power and Communications; Notice of Intent To File License...: Whitestone Power and Communications. e. Name of Project: Microturbine Hydrokinetic River-In-Stream...

  3. 76 FR 5582 - Whitestone Power and Communications; Notice of Intent To File License Application, Filing of...

    Science.gov (United States)

    2011-02-01

    ... pontoon; (3) a 100-kilowatt turbine/generator unit; (4) a 33-foot-long, 3.5-foot-wide gangway from the... Energy Regulatory Commission Whitestone Power and Communications; Notice of Intent To File License..., 2011. d. Submitted By: Whitestone Power and Communications. e. Name of Project: Whitestone...

  4. 75 FR 30440 - Biweekly Notice: Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-06-01

    ... (75 FR 27825). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... the probability or consequences of any previously evaluated accident, EGC did not consider the...

  5. 75 FR 33839 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-06-15

    ...) surveillance requirement (SR) 3.1.4.3 is not required for control rod drive 22 through cycle 21 or until the..., 2010 (75 FR 30440). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process...

  6. 75 FR 43959 - Northern California Power Agency; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2010-07-27

    ... Stanislaus River, in Tuolumne and Alpine Counties, California. g. Filed Pursuant to: Federal Power Act, 16 U... elevation and minimum water volume limits at Lake Alpine. Article 403 of the project license requires that the licensee maintain Lake Alpine at full pool (elevation 7,302 feet) from June 1 to November 1st...

  7. 76 FR 80972 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-12-27

    ...), Unit 2, fall 2012 refueling outage (RFO), the replacement steam generators will be installed. To..., Unit 2 steam generator replacement project (SGRP). The one-time license condition establishes special... of large heavy load lifts associated with the SQN, Unit 2, steam generator replacement...

  8. 78 FR 22576 - Application and Amendment to Facility Operating License Involving Proposed No Significant Hazards...

    Science.gov (United States)

    2013-04-16

    ... steady state full power operation'' shall be based upon the steam generators being operated under... operation of the steam generators nor introduce any changes to existing design functions of systems... temporary change to the steam generator management program and the license condition for maximum power....

  9. 75 FR 39975 - Applications and Amendments to Facility Operating Licenses Involving No Significant Hazards...

    Science.gov (United States)

    2010-07-13

    ... mode of plant operation and does not involve a physical modification to the plant. The change will not... Technical Specification (TS) 5.5.9 to exclude portions of the Steam Generator (SG) tube from periodic SG... FR 37471). Notice of Consideration of Issuance of Amendments to Facility Operating Licenses,...

  10. Application of computational intelligence to biology

    CERN Document Server

    Sekhar, Akula

    2016-01-01

    This book is a contribution of translational and allied research to the proceedings of the International Conference on Computational Intelligence and Soft Computing. It explains how various computational intelligence techniques can be applied to investigate various biological problems. It is a good read for Research Scholars, Engineers, Medical Doctors and Bioinformatics researchers.

  11. Marine Carotenoids: Biological Functions and Commercial Applications

    NARCIS (Netherlands)

    Vilchez, C.; Forján, E.; Cuaresma, M.; Bédmar, F.; Garbayo, I.; Vega, J.M.

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functi

  12. Applicability of Computational Systems Biology in Toxicology

    DEFF Research Database (Denmark)

    Kongsbak, Kristine Grønning; Hadrup, Niels; Audouze, Karine Marie Laure;

    2014-01-01

    and databases are used to model and predict effects of chemicals on, for instance, human health. In toxicology, computational systems biology enables identification of important pathways and molecules from large data sets; tasks that can be extremely laborious when performed by a classical literature search....... However, computational systems biology offers more advantages than providing a high-throughput literature search; it may form the basis for establishment of hypotheses on potential links between environmental chemicals and human diseases, which would be very difficult to establish experimentally....... This is possible due to the existence of comprehensive databases containing information on networks of human protein–protein interactions and protein–disease associations. Experimentally determined targets of the specific chemical of interest can be fed into these networks to obtain additional information that can...

  13. Stochastic chemical kinetics theory and (mostly) systems biological applications

    CERN Document Server

    Érdi, Péter

    2014-01-01

    This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.

  14. Application of vibrational microspectroscopy to biology and medicine

    OpenAIRE

    Singh, Bhawana; Gautam, Rekha; Kumar, Srividya; Kumar, Vinay BN; Nongthomba, Upendra; Nandi, Dipankar; Mukherjee, Geetashree; Santosh, Vani; Somasundaram, Kumaravel; Umapathy, Siva

    2012-01-01

    Vibrational microspectroscopic (Raman and infrared (IR)) techniques are rapidly emerging as effective tools to probe the basic processes of life. This review mainly focuses on the applications of Raman and IR microspectroscopy to biology and biomedicine, ranging from studies on cellular components in single cells to advancement in techniques for in vitro to in vivo applications. These techniques have proved to be instrumental in studying the biological specimen with minimum perturbation, i.e....

  15. Application of IAEA nuclear safety standards to the licensing of Chashma nuclear power plant Unit-2

    International Nuclear Information System (INIS)

    The theme of the paper is to describe a methodology to validate and verify the IAEA safety standards by applying them to the whole licensing process of the second 325 MW(e) PWR (C2) to be constructed at Chashma, Pakistan. The IAEA safety standards have so far not been used to license a nuclear power plant. A surge in installation of new nuclear power plants is expected in the next decades due to restrictions on the emission of greenhouse gases, increased electricity demands, closure of coalfields, regulatory approval of new designs of nuclear power plants in the USA, economic competitiveness of existing plants, etc. Therefore, there is a need for internationally accepted nuclear safety standards. Before describing the methodology proposed by PNRA to achieve this aim, as a prelude, the rule making procedure and history of applying IAEA safety standards in Pakistan is briefly discussed. Pakistan has been applying the deterministic approach instead of reference plant approach for licensing of its nuclear power plants imported from China. The importance of a complete regulatory pyramid has been discussed and our experience of setting up such a regulatory pyramid has been highlighted. In addition, our experience of applying IAEA safety standards in conjunction with other standards to licensing of C1 has been described. The advantages and disadvantages of applying IAEA safety standards for licensing and some significant improvements needed in light of our experience have been identified. In view of the long history of cooperation between China and Pakistan in general, and particularly between regulatory bodies of the two countries, this validation and verification exercise can be put to mutual benefit. The international nuclear community can share the benefits and consequently, in the near future, IAEA safety standards may be used for licensing of imported nuclear power plants, especially when both the exporter and importer are developing countries. It would be the

  16. Standard format and content of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    This document discusses the information that should be provided in the Safety Analysis Report and establishes a uniform format for presenting the information necessary to fulfill the licensing requirements for land disposal of radioactive waste called for in 10 CFR 61. The uniform format will (1) help ensure that the Safety Analysis Report contains the information required by 10 CFR 61, (2) aid the applicant and NRC staff in ensuring that the information is complete, (3) help persons reading the Safety Analysis Report to locate information, and (4) contribute to shortening the time needed for the review process

  17. Parameter Selection for Department of Energy Spent Nuclear Fuel to be Used in the Yucca Mountain License Application

    Energy Technology Data Exchange (ETDEWEB)

    D. L. Fillmore

    2003-10-01

    This report contains the chemical, physical, and radiological parameters that were chosen to represent the U.S. Department of Energy spent nuclear fuel in the Yucca Mountain license application. It also contains the selected packaging requirements for the various fuel types and the criticality controls that were used. The data are reported for representative fuels and bounding fuels in groups of fuels that were selected for the analysis. The justification for the selection of each parameter is given. The data reported were not generated under any quality assurance program.

  18. Grafting of Porous Polymers for Biological Applications

    International Nuclear Information System (INIS)

    Research on application of radiation processing to polymers is mainly focused by the National Atomic Commission (CNEA). The Agricultural and Industrial Applications Laboratory Unit operates at the Ezeiza Atomic Center since the end of 1980s. Since 1997 a new research group headed by Dr. O. Cascone and Dr. M. Grasselli, devoted to downstream processing of proteins from the University of Buenos Aires, was involved in the implementation of grafting techniques in collaboration with Dr. E. Smolko from CNEA. In 1999 Dr. M. Grasselli moved to the Universidad Nacional de Quilmes where he continued working on application of gamma radiation to materials for biotechnological process. (author)

  19. How synthetic biology will reconsider natural bioluminescence and its applications.

    Science.gov (United States)

    Reeve, Benjamin; Sanderson, Theo; Ellis, Tom; Freemont, Paul

    2014-01-01

    As our understanding of natural biological systems grows, so too does our ability to alter and rebuild them. Synthetic biology is the application of engineering principles to biology in order to design and construct novel biological systems for specific applications. Bioluminescent organisms offer a treasure trove of light-emitting enzymes that may have applications in many areas of bioengineering, from biosensors to lighting. A few select bioluminescent organisms have been well researched and the molecular and genetic basis of their luminescent abilities elucidated, with work underway to understand the basis of luminescence in many others. Synthetic biology will aim to package these light-emitting systems as self-contained biological modules, characterize their properties, and then optimize them for use in other chassis organisms. As this catalog of biological parts grows, synthetic biologists will be able to engineer complex biological systems with the ability to emit light. These may use luminescence for an array of disparate functions, from providing illumination to conveying information or allowing communication between organisms. PMID:25216951

  20. Nanopatterning and nanoscale devices for biological applications

    CERN Document Server

    Šelimović, Seila

    2014-01-01

    ""This book is a good reference for researchers interested in realizing bio-applications based on micro- and nanostructures, where their interface with liquids and biomolecules is the key point. The most important 'players' of micro- and nano-bioengineering are considered, from DNA to proteins and cells. The work is a good merger of basic concepts and real examples of applications.""-Danilo Demarchi, Politecnico di Torino, Italy

  1. The pre-licensing of a multi-purpose hybrid research reactor for high-tech applications 'MYRRHA'

    International Nuclear Information System (INIS)

    The Belgian Nuclear Research Centre in Mol has been working for several years on the design of a multi-purpose flexible irradiation facility in order to replace the ageing BR2, a multipurpose materials testing reactor (MTR), in operation since 1962. MYRRHA, a flexible fast spectrum research reactor is conceived as an accelerator driven system (ADS), able to operate in sub-critical and critical modes. It contains a proton accelerator of 600 MeV, a spallation target and a multiplying medium with MOX fuel, cooled by liquid lead-bismuth (Pb-Bi). Since February 2011, the Belgian Nuclear Research Centre has engaged in a 'pre-licensing' process with the regulatory authority for an estimated period up to mid 2014. The paper presents on the one hand the objectives of the pre-licensing phase as well as its implementation process and on the other hand, 2 implementing instruments which have been developed by the regulatory authority providing guidance to the designer of MYRRHA in order to meet the pre-licensing phase objectives. The first instrument is a strategic note for the design and operation of MYRRHA where as the second instrument is a guidance document for the format and content of a design options and provisions file (DOPF). Both instruments have been developed taking into account that MYRRHA is an irradiation facility using a Generation IV nuclear power system's type technology (liquid metal cooled fast neutron reactor). The strategic note overview aims to cover the safety approach as well as the security requirements and safeguards obligation applicable to MYRRHA. In particular, in the strategic note, a specific attention has been paid in order to ensure that a safety, security and safeguards integrated approach will drive the development of the MYRRHA design. The safety approach focuses on the safety goals and the minimum safety objectives set by the regulatory authority for this innovative design. The DOPF overview presents its objectives and structure resuming

  2. Click chemistry mediated functionalization of vertical nanowires for biological applications

    DEFF Research Database (Denmark)

    Vutti, Surendra; Schoffelen, Sanne; Bolinsson, Jessica;

    2016-01-01

    Semiconductor nanowires (NWs) are gaining significant importance in various biological applications, such as biosensing and drug delivery. Efficient and controlled immobilization of biomolecules on the NW surface is crucial for many of these applications. Here, we present for the first time the use...

  3. Auxin Biology: Applications and the Mechanisms Behind

    OpenAIRE

    Skůpa, P. (Petr); Opatrný, Z.; Petrášek, J. (Jan)

    2014-01-01

    This chapter describes the state of the contemporary knowledge of auxin action reflected in its applications in agriculture and biotechnology. We summarise the current understanding of the mechanism of action for endogenous and major synthetic auxins highlighting their morphogenic character that modulates numerous aspects of plant development. Various auxins and auxin-like compounds are used in techniques of plant vegetative propagation, in vitro culture and regeneration, and they play also a...

  4. Directed evolution and synthetic biology applications to microbial systems.

    Science.gov (United States)

    Bassalo, Marcelo C; Liu, Rongming; Gill, Ryan T

    2016-06-01

    Biotechnology applications require engineering complex multi-genic traits. The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them. However, complex phenotypes can be engineered at the systems level, utilizing directed evolution strategies that drive whole biological systems toward desired phenotypes without requiring prior knowledge of the genetic basis of the targeted trait. Recent developments in the synthetic biology field accelerates the directed evolution cycle, facilitating engineering of increasingly complex traits in biological systems. In this review, we summarize some of the most recent advances in directed evolution and synthetic biology that allows engineering of complex traits in microbial systems. Then, we discuss applications that can be achieved through engineering at the systems level. PMID:27054950

  5. Hidden Markov Models and their Applications in Biological Sequence Analysis

    OpenAIRE

    Yoon, Byung-Jun

    2009-01-01

    Hidden Markov models (HMMs) have been extensively used in biological sequence analysis. In this paper, we give a tutorial review of HMMs and their applications in a variety of problems in molecular biology. We especially focus on three types of HMMs: the profile-HMMs, pair-HMMs, and context-sensitive HMMs. We show how these HMMs can be used to solve various sequence analysis problems, such as pairwise and multiple sequence alignments, gene annotation, classification, similarity search, and ma...

  6. Current and Future Applications of Thermal-Hydraulic and Neutronic Best- Estimate Methods in Support of the Swiss Licensing Process

    International Nuclear Information System (INIS)

    Best-estimate methods are employed within the STARS project at PSI. The project provides independent technical expertise primarily to HSK in support of the Swiss licensing process in the area of deterministic safety analysis, and covers applications ranging from operational occurrences as well as beyond-design-basis transients. Some examples are presented: an assessment of the coolability of a PWR for reduced availability of ECCS, timing studies for an MSIV-ATWS event in a BWR in order to quantify the effect of delayed operator actions, predictions of planned start-up tests and research on BWR-stability to deepen the understanding of the phenomenon. Future work will include an extensive use of 3D-kinetics in transient analysis and the development of a comprehensive uncertainty methodology. Calculations on high burnup fuel behavior for RIA- and LOCA-scenarios are planned; also CFD applications will be developed to assess mixing problems in reactor geometries on a rigorous basis. (authors)

  7. Recent applications of synthetic biology tools for yeast metabolic engineering

    DEFF Research Database (Denmark)

    Jensen, Michael Krogh; Keasling, Jay

    2015-01-01

    engineer microbial chemical factories has steadily decreased, improvement is still needed. Through the development of synthetic biology tools for key microbial hosts, it should be possible to further decrease the development times and improve the reliability of the resulting microorganism. Together with...... continuous decreases in price and improvements in DNA synthesis, assembly and sequencing, synthetic biology tools will rationalize time-consuming strain engineering, improve control of metabolic fluxes, and diversify screening assays for cellular metabolism. This review outlines some recently developed...... synthetic biology tools and their application to improve production of chemicals and fuels in yeast. Finally, we provide a perspective for the challenges that lie ahead....

  8. Applications of dynamical systems in biology and medicine

    CERN Document Server

    Radunskaya, Ami

    2015-01-01

    This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control.  Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction.  Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation. .

  9. Structural biology applications of solid state MAS DNP NMR

    Science.gov (United States)

    Akbey, Ümit; Oschkinat, Hartmut

    2016-08-01

    Dynamic Nuclear Polarization (DNP) has long been an aim for increasing sensitivity of nuclear magnetic resonance (NMR) spectroscopy, delivering spectra in shorter experiment times or of smaller sample amounts. In recent years, it has been applied in magic angle spinning (MAS) solid-state NMR to a large range of samples, including biological macromolecules and functional materials. New research directions in structural biology can be envisaged by DNP, facilitating investigations on very large complexes or very heterogeneous samples. Here we present a summary of state of the art DNP MAS NMR spectroscopy and its applications to structural biology, discussing the technical challenges and factors affecting DNP performance.

  10. Biological applications of ultraviolet free-electron lasers

    International Nuclear Information System (INIS)

    This review examines the possibilities for biological research using the three ultraviolet free-electron lasers that are nearing operational status in the US. The projected operating characteristics of major interest in biological research of the free-electron lasers at Brookhaven National Laboratory, the Thomas Jefferson National Accelerator Facility, and Duke University are presented. Experimental applications in the areas of far- and vacuum ultraviolet photophysics and photochemistry, structural biology, environmental photobiology, and medical research are discussed and the prospects for advances in these areas, based upon the characteristics of the new ultraviolet free-electron lasers, are evaluated

  11. 47 CFR 25.137 - Application requirements for earth stations operating with non-U.S. licensed space stations.

    Science.gov (United States)

    2010-10-01

    ... system in the relevant foreign markets. The exhibit required by this paragraph must also include a... enter the U.S. market. If the transferee or assignee is not licensed by or seeking a license from a... ruling to access the U.S. market must demonstrate that the non-U.S.-licensed space station has...

  12. Licensing experiences of safety critical software systems in nuclear applications a case study

    International Nuclear Information System (INIS)

    This paper summarizes results of reviews on the safety, critical software performed during the licensing process for the new Wolsung units. Each of these CANDU-type nuclear power plants has two micro-computerized shutdown systems. The SDS No. 1 program is graphically programmed in such a manner that its development process does not essentially differ from the design process of the conventional analog counterpart. This approach is understandable even to a reviewer in the regulatory agency without additional training in software engineering. The confidence in the reliability of this system is strengthened by the reverse verification and increased by extensive testing such as the reliability test. Concerning SDS No. 2, the development process is significantly influenced by the software cost reduction project of the U.S. naval research laboratory, and is, as a whole, clear and well structured except for the modules related to the operation of the computer itself. These modules contain some algorithms which are not easy to understand. However, their correctness verifications are requested by the reviewer and supplemented by the developer. After the clarification of these issues, there are no substantial problems that constitute a significant impediment to licensing. 32 refs., 7 figs

  13. Biologically active extracts with kidney affections applications

    Science.gov (United States)

    Pascu (Neagu), Mihaela; Pascu, Daniela-Elena; Cozea, Andreea; Bunaciu, Andrei A.; Miron, Alexandra Raluca; Nechifor, Cristina Aurelia

    2015-12-01

    This paper is aimed to select plant materials rich in bioflavonoid compounds, made from herbs known for their application performances in the prevention and therapy of renal diseases, namely kidney stones and urinary infections (renal lithiasis, nephritis, urethritis, cystitis, etc.). This paper presents a comparative study of the medicinal plant extracts composition belonging to Ericaceae-Cranberry (fruit and leaves) - Vaccinium vitis-idaea L. and Bilberry (fruit) - Vaccinium myrtillus L. Concentrated extracts obtained from medicinal plants used in this work were analyzed from structural, morphological and compositional points of view using different techniques: chromatographic methods (HPLC), scanning electronic microscopy, infrared, and UV spectrophotometry, also by using kinetic model. Liquid chromatography was able to identify the specific compounds of the Ericaceae family, present in all three extracts, arbutosid, as well as specific components of each species, mostly from the class of polyphenols. The identification and quantitative determination of the active ingredients from these extracts can give information related to their therapeutic effects.

  14. Miniature spectroscopic instrumentation: Applications to biology and chemistry

    Science.gov (United States)

    Bacon, Christina P.; Mattley, Yvette; DeFrece, Ronald

    2004-01-01

    Spectroscopy is a fundamental analytical tool utilized throughout all of the sciences. For chemistry and biology alone, there are thousands of applications. In the past two decades there have been monumental advances in the miniaturization of components used in spectrophotometric systems. The key components include detector arrays, laser diodes, and fiber optics. Currently, there are numerous commercially available miniature spectrometer systems as well as discrete components that are used by researchers in designing their own systems. A comprehensive summary of current instrumentation available for the design and development of miniaturized spectroscopy applications is described, including detectors, wavelength discriminating components, light sources, and sampling assemblies. Recommendations are made for designing spectrometer systems for specific applications. Current literature is reviewed for chemical and biological applications specifically using miniaturized spectrometer systems with the focus being on ultraviolet-visible-near-infrared spectrometers. The applications include laboratory applications, environmental sensing, on-site industrial analyses, botany and ecology applications, and finally clinical and biochemical studies. Additionally, microspectrometers, two-dimensional arrays, and photonics crystals are discussed in regards to their future role in chemistry and biology applications.

  15. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  16. 21 CFR 601.2 - Applications for biologics licenses; procedures for filing.

    Science.gov (United States)

    2010-04-01

    ... methods; data establishing stability of the product through the dating period; sample(s) representative of... section: (1) Therapeutic DNA plasmid products; (2) Therapeutic synthetic peptide products of 40 or fewer... which is a therapeutic DNA plasmid product, therapeutic synthetic peptide product of 40 or fewer...

  17. 78 FR 19714 - User Fees and Refunds for Premarket Approval Applications and Device Biologics License...

    Science.gov (United States)

    2013-04-02

    ..., Silver Spring, MD 20993-0002 or Office of Communication, Outreach and Development (HFM-40), Center for... and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville,...

  18. Experience in Application of Uncertainty Methods, Participation in Uncertainty Methods Study and Review of Methods Used in Licensing

    International Nuclear Information System (INIS)

    The paper covered the following topics: - application of uncertainty evaluation methods in Germany, - conclusions of the 'Uncertainty Methods Study', - short overview on the international situation in licensing, - further support development in GRS, future co-operation with FZK. The following conclusions had been drawn from the performed uncertainty analyses: - there were high requirements in determining uncertain input parameters: selection of suitable experimental and analytical information to determine ranges and probability distributions, and transfer of measured data into these ranges and distributions, - determination of ranges of calculation results were recommended for codes developed at GRS and important accident scenarios, - uncertainty importance ranking guides were leading to improvement of knowledge and effective code improvements. Recommendations had also been made with respect to the Uncertainty Method Study (UMS): - collection, qualification, review and dissemination of uncertainty data should be made more systematic, - code manuals should include relevant uncertainty information, - more efforts should be made to transform data measured in experiments and compared with posttest calculations into model parameters with uncertainties, - uncertainty analysis should be performed if useful conclusions are to be obtained from Best Estimate codes, - new generations of codes should provide 'internal assessment of uncertainty', - information gained in the UMS should be used to inform decisions on the conduct of uncertainty analyses, for example in the light of licensing requirements

  19. Biological Applications of Extraordinary Electroconductance (EEC)

    Science.gov (United States)

    Tran, L. C.; Werner, F. M.; Solin, S. A.

    2014-03-01

    Rapid detection of biomolecular concentration is a fundamental goal for lab on a chip diagnostic systems. The Extraordinary Electroconductance (EEC) sensor, a stacked, AuTi-GaAs metal semiconductor hybrid structure (MSH), has been previously demonstrated to have an electric field sensitivity of 3.05V/cm in a mesoscopic-scale structure fabricated at the center of a parallel plate capacitor. In this work, we demonstrate the first successful application of EEC sensors as electrochemical detectors of molecular binding to the sensor surface. The negatively charged avidin derivative, captavidin, was applied with varying captavidin concentrations in phosphate buffered saline (PBS). The four-point measured resistance of bare EEC sensors was shown to increase by a factor of four due to captavidin binding at the sensor surface, as compared to a baseline binding assay in which the captavidin binding sites were blocked. Calculations for approximate electric field strengths introduced by a bound captavidin molecule will also presented. EEC sensors' four point measurements showed robustness and stability in spite of variations in the functional, linking layer. S.A.S. is a co-founder of and has a financial interest in PixelEXX, a start-up company whose mission is to market imaging arrays.

  20. Preparing as an organization, to submit or to review a construction license application for a DGR of ILW and HLW in France. French National Case - Andra - Preparing to Submit Cigeo's Creation License Application

    International Nuclear Information System (INIS)

    The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste. Since the first French Act on nuclear waste management research (1991), Andra has carried out twenty years of conceptual and basic studies on the subject, leading in particular to the feasibility demonstration in 2005 and to the choice of the detailed reconnaissance zone (ZIRA) in 2010. Taking advantage from this work, Andra has now reached a new phase where the project is engaging in the design of the industrial installation named Cigeo. At this stage, the further development of the project implies that Andra undertakes a multiplicity of actions in order to successfully reach various external and internal key milestones. Of paramount importance is the careful articulation between the regulatory authorization and decision processes and the outcome of the industrial installation design phases. In 2006 was built a regulatory framework that plans a succession of step by step decisions stages: 2013: Public debate on reversibility, memory keeping, environmental and health survey modalities, dialogue with the local stakeholders to harmoniously define and plan the external infrastructures that have to be developed to support the construction and the operation of Cigeo (roads, railway tracks and terminal, power and water supplies, etc.). 2015: Creation license application and start of the regulatory review process (notably various plans of the installation, the description of the solution envisaged for the closure of the facility, the preliminary safety case (operational safety, long-term safety, protection against malevolent actions, management of incidental situations, preliminary acceptance criteria), environmental impact studies (health, salubrity, transports, human activities, nature, patrimonial aspects). 2016-2017: new parliamentary Act on the reversibility conditions of the

  1. Biological applications of confocal fluorescence polarization microscopy

    Science.gov (United States)

    Bigelow, Chad E.

    Fluorescence polarization microscopy is a powerful modality capable of sensing changes in the physical properties and local environment of fluorophores. In this thesis we present new applications for the technique in cancer diagnosis and treatment and explore the limits of the modality in scattering media. We describe modifications to our custom-built confocal fluorescence microscope that enable dual-color imaging, optical fiber-based confocal spectroscopy and fluorescence polarization imaging. Experiments are presented that indicate the performance of the instrument for all three modalities. The limits of confocal fluorescence polarization imaging in scattering media are explored and the microscope parameters necessary for accurate polarization images in this regime are determined. A Monte Carlo routine is developed to model the effect of scattering on images. Included in it are routines to track the polarization state of light using the Mueller-Stokes formalism and a model for fluorescence generation that includes sampling the excitation light polarization ellipse, Brownian motion of excited-state fluorophores in solution, and dipole fluorophore emission. Results from this model are compared to experiments performed on a fluorophore-embedded polymer rod in a turbid medium consisting of polystyrene microspheres in aqueous suspension. We demonstrate the utility of the fluorescence polarization imaging technique for removal of contaminating autofluorescence and for imaging photodynamic therapy drugs in cell monolayers. Images of cells expressing green fluorescent protein are extracted from contaminating fluorescein emission. The distribution of meta-tetrahydroxypheny1chlorin in an EMT6 cell monolayer is also presented. A new technique for imaging enzyme activity is presented that is based on observing changes in the anisotropy of fluorescently-labeled substrates. Proof-of-principle studies are performed in a model system consisting of fluorescently labeled bovine

  2. Application of Bioinformatics and Systems Biology in Medicinal Plant Studies

    Institute of Scientific and Technical Information of China (English)

    DENG You-ping; AI Jun-mei; XIAO Pei-gen

    2010-01-01

    One important purpose to investigate medicinal plants is to understand genes and enzymes that govern the biological metabolic process to produce bioactive compounds.Genome wide high throughput technologies such as genomics,transcriptomics,proteomics and metabolomics can help reach that goal.Such technologies can produce a vast amount of data which desperately need bioinformatics and systems biology to process,manage,distribute and understand these data.By dealing with the"omics"data,bioinformatics and systems biology can also help improve the quality of traditional medicinal materials,develop new approaches for the classification and authentication of medicinal plants,identify new active compounds,and cultivate medicinal plant species that tolerate harsh environmental conditions.In this review,the application of bioinformatics and systems biology in medicinal plants is briefly introduced.

  3. Flow cytometric applications of tumor biology: prospects and pitfalls

    International Nuclear Information System (INIS)

    A brief review of cytometry instrumentation and its potential applications in tumor biology is presented using our recent data. Age-distribution measurements of cells from spontaneous dog tumors and cultured cells after exposure to x rays, alpha particles, or adriamycin are shown. The data show that DNA fluorescence measurements have application in the study of cell kinetics after either radiation or drug treatment. Extensive and careful experimentation is needed to utilize the sophisticated developments in flow cytometry instrumentation

  4. Novel computational biology methods and their applications to drug discovery

    Institute of Scientific and Technical Information of China (English)

    Sharangdhar S. PHATAK; Hoang T. TRAN; Shuxing ZHANG

    2011-01-01

    Computational biology methods are now firmly entrenched in the drug discovery process.These methods focus on modeling and simulations of biological systems to complement and direct conventional experimental approaches.Two important branches of computational biology include protein homology modeling and the computational biophysics method of molecular dynamics.Protein modeling methods attempt to accurately predict three-dimensional (3D) structures of uncrystallized proteins for subsequent structure-based drug design applications.Molecular dynamics methods aim to elucidate the molecular motions of the static representations of crystallized protein structures.In this review we highlight recent novel methodologies in the field of homology modeling and molecular dynamics.Selected drug discovery applications using these methods conclude the review.

  5. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  6. Issues in the review of a license application for an above grade low-level radioactive waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Ringenberg, J.D. [Nebraska Dept. of Environmental Quality, NE (United States)

    1993-03-01

    In December 1987, Nebraska was selected by the Central Interstate Compact (CIC) Commission as the host state for the construction of a low-level radioactive waste disposal facility. After spending a year in the site screening process, the Compact`s developer, US Ecology, selected three sites for detailed site characterization. These sites were located in Nemaha, Nuckolls and Boyd Counties. One year later the Boyd County site was selected as the preferred site and additional site characterization studies were undertaken. On July 29, 1990, US Ecology submitted a license application to the Nebraska Department of Environmental Control (now Department of Environmental Quality-NDEQ). This paper will present issues that the NDEQ has dealt with since Nebraska`s selection as the host state for the CIC facility.

  7. Differential Scanning Calorimetry Techniques: Applications in Biology and Nanoscience

    OpenAIRE

    Gill, Pooria; Moghadam, Tahereh Tohidi; Ranjbar, Bijan

    2010-01-01

    This paper reviews the best-known differential scanning calorimetries (DSCs), such as conventional DSC, microelectromechanical systems-DSC, infrared-heated DSC, modulated-temperature DSC, gas flow-modulated DSC, parallel-nano DSC, pressure perturbation calorimetry, self-reference DSC, and high-performance DSC. Also, we describe here the most extensive applications of DSC in biology and nanoscience.

  8. Dealing with the current permissibility application for constructing a spent fuel DGR in Sweden. SKB's license applications for a spent fuel repository

    International Nuclear Information System (INIS)

    The nuclear power utilities in Sweden were in 1976 obliged to demonstrate a safe method for final disposal of spent fuel in order to start operation of new reactors. This initiated a comprehensive research, development and demonstration programme and the development of the KBS-method for final disposal. A new Nuclear Activities Act in 1984 gave the reactor owners full technical and financial responsibility for the waste. They gave in turn SKB the responsibility for all nuclear waste management. Reprocessing was no longer required and direct disposal of the spent fuel has, since then, been the main alternative. Alternative methods for final disposal have been evaluated and compared to the KBS-3-method but it has remained the preferred alternative. A comprehensive research, development and demonstration programme to strengthen the scientific basis and to refine the KBS-3-method has been operated by SKB since then. The site selection process for the final repository for spent nuclear fuel was initiated in 1992. The work included general siting studies at the national and the municipal level and in 2002, SKB initiated site investigations for siting of a final repository on two sites: the Simpevarp and Laxemar areas and the Forsmark area. At the same time, the work on preparing license applications to construct and operate an encapsulation plant and a final repository for spent fuel was started. In June 2009, SKB announced Forsmark as the selected site for the final repository. This paper reviews the applicable legislation and describes the license application, the licensing review and the preparations for implementation

  9. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  10. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  11. Cryo-focused-ion-beam applications in structural biology.

    Science.gov (United States)

    Rigort, Alexander; Plitzko, Jürgen M

    2015-09-01

    The ability to precisely control the preparation of biological samples for investigations by electron cryo-microscopy is becoming increasingly important for ultrastructural imaging in biology. Precision machining instruments such as the focused ion beam microscope (FIB) were originally developed for applications in materials science. However, today we witness a growing use of these tools in the life sciences mainly due to their versatility, since they can be used both as manipulation and as imaging devices, when complemented with a scanning electron microscope (SEM). The advent of cryo-preparation equipment and accessories made it possible to pursue work on frozen-hydrated biological specimens with these two beam (FIB/SEM) instruments. In structural biology, the cryo-FIB can be used to site-specifically thin vitrified specimens for transmission electron microscopy (TEM) and tomography. Having control over the specimen thickness is a decisive factor for TEM imaging, as the thickness of the object under scrutiny determines the attainable resolution. Besides its use for TEM preparation, the FIB/SEM microscope can be additionally used to obtain three-dimensional volumetric data from biological specimens. The unique combination of an imaging and precision manipulation tool allows sequentially removing material with the ion beam and imaging the milled block faces by scanning with the electron beam, an approach known as FIB/SEM tomography. This review covers both fields of cryo-FIB applications: specimen preparation for TEM cryo-tomography and volume imaging by cryo-FIB/SEM tomography. PMID:25703192

  12. 21 CFR 601.5 - Revocation of license.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Revocation of license. 601.5 Section 601.5 Food... LICENSING General Provisions § 601.5 Revocation of license. (a) A biologics license shall be revoked upon... for, and offering an opportunity for a hearing on the proposed revocation if the Commissioner...

  13. Integrated graphene/nanoparticle hybrids for biological and electronic applications

    Science.gov (United States)

    Nguyen, Kim Truc; Zhao, Yanli

    2014-05-01

    The development of novel graphene/nanoparticle hybrid materials is currently the subject of tremendous research interest. The intrinsic exceptional assets of both graphene (including graphene oxide and reduced graphene oxide) and nanoparticles render their hybrid materials synergic properties that can be useful in various applications. In this feature review, we highlight recent developments in graphene/nanoparticle hybrids and their promising potential in electronic and biological applications. First, the latest advances in synthetic methods for the preparation of the graphene/nanoparticle hybrids are introduced, with the emphasis on approaches to (1) decorate nanoparticles onto two-dimensional graphene and (2) wrap nanoparticles with graphene sheets. The pros and cons of large-scale synthesis are also discussed. Then, the state-of-the-art of graphene/nanoparticle hybrids in electronic and biological applications is reviewed. For electronic applications, we focus on the advantages of using these hybrids in transparent conducting films, as well as energy harvesting and storage. Biological applications, electrochemical biosensing, bioimaging, and drug delivery using the hybrids are showcased. Finally, the future research prospects and challenges in this rapidly developing area are discussed.

  14. Application of synthetic biology in cyanobacteria and algae

    Directory of Open Access Journals (Sweden)

    Bo eWang

    2012-09-01

    Full Text Available Cyanobacteria and algae are becoming increasingly attractive cell factories for producing renewable biofuels and chemicals due to their ability to capture solar energy and CO2 and their relatively simple genetic background for genetic manipulation. Increasing research efforts from the synthetic biology approach have been made in recent years to modify cyanobacteria and algae for various biotechnological applications. In the article, we critically review recent progresses in developing genetic tools for characterizing or manipulating cyanobacteria and algae, the applications of genetically modified strains for synthesizing renewable products such as biofuels and chemicals. In addition, the emergent challenges in the development and application of synthetic biology for cyanobacteria and algae are also discussed.

  15. Application of PLUTO Test Facility for U. S. NRC Licensing of a Fuel Assembly

    International Nuclear Information System (INIS)

    The fuel assembly of the PLUS-7 loaded in the APR-1400 follows the same schedule. Meanwhile, In July 1998, the U.S. NRC adopted a research plan to address the effects of high burnup from a Loss of Coolant Accident (LOCA). From these programs, several important technical findings for rule revision were obtained. Based on the technical findings, the U. S. NRC has amended the 10 CFR 50.46 which will be proclaimed sooner or later. Through the amendment, a LOCA analysis on the fuel assembly has to show the safety at both a fresh and End of Life (EOL) state. The U. S. NRC has already required EOL effects on seismic/LOCA performance for a fuel assembly since 1998. To obtain U.S NRC licensing of a fuel assembly, based on the amendment of 10CFR50.46, a LOCA analysis of the fuel assembly has to show safety both fresh and EOL states. The proper damping factor of the fuel assembly measured at the hydraulic test loop for a dynamic model in a LOCA and a seismic analysis code are at least required. In this paper, we have examined the damping technologies and compared the test facility of PLUTO with others in terms of performance. PLUTO has a better performance on the operating conditions than any others

  16. Application of PLUTO Test Facility for U. S. NRC Licensing of a Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dongseok; Shin, Changhwan; Lee, Kanghee; Kang, Heungseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    The fuel assembly of the PLUS-7 loaded in the APR-1400 follows the same schedule. Meanwhile, In July 1998, the U.S. NRC adopted a research plan to address the effects of high burnup from a Loss of Coolant Accident (LOCA). From these programs, several important technical findings for rule revision were obtained. Based on the technical findings, the U. S. NRC has amended the 10 CFR 50.46 which will be proclaimed sooner or later. Through the amendment, a LOCA analysis on the fuel assembly has to show the safety at both a fresh and End of Life (EOL) state. The U. S. NRC has already required EOL effects on seismic/LOCA performance for a fuel assembly since 1998. To obtain U.S NRC licensing of a fuel assembly, based on the amendment of 10CFR50.46, a LOCA analysis of the fuel assembly has to show safety both fresh and EOL states. The proper damping factor of the fuel assembly measured at the hydraulic test loop for a dynamic model in a LOCA and a seismic analysis code are at least required. In this paper, we have examined the damping technologies and compared the test facility of PLUTO with others in terms of performance. PLUTO has a better performance on the operating conditions than any others.

  17. Application of the best-estimate approach for the licensing process of NPPS with RBMK reactors

    International Nuclear Information System (INIS)

    According to the international practice, the best-estimate approach is used mainly for Loss of Coolant Accident (LOCA) in reactor cooling circuit type accidents. In Lithuania the best estimate approach was successfully applied not only for LOCA, but also for accident confinement system response and processes in fuel rods analyses. This paper presents the following three examples of best-estimate accident analysis, developed for the licensing of Ignalina NPP with RBMK-1500 reactors: Large LOCA case in main circulation circuit; Processes in reactor cavity after rupture of fuel channels; Change of fuel rod parameters during operation. Thermal hydraulic analyses were performed by employing best estimate thermal-hydraulic codes RELAP5 Mod3.2 (for the analysis of reactor cooling circuit response) and CONTAIN (for the analysis of reactor cavity response). In order to evaluate the uncertainties of calculation, the GRS methodology and computer code of statistical methods SUSA 3.5 was employed. The main findings may be applied for the RBMK-1000 reactors, operating in Russia, and for other light water reactors. (author)

  18. Application of enriched stable isotopes as tracers in biological systems

    DEFF Research Database (Denmark)

    Stürup, Stefan; Hansen, Helle Rüsz; Gammelgaard, Bente

    2008-01-01

    The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry...... development of new methodologies coupled with more advanced compartmental and mathematical models for the distribution of elements in living organisms has enabled a broader use of enriched stable isotope experiments in the biological sciences. This review discusses the current and future uses of enriched...

  19. An introduction to stochastic processes with applications to biology

    CERN Document Server

    Allen, Linda J S

    2010-01-01

    An Introduction to Stochastic Processes with Applications to Biology, Second Edition presents the basic theory of stochastic processes necessary in understanding and applying stochastic methods to biological problems in areas such as population growth and extinction, drug kinetics, two-species competition and predation, the spread of epidemics, and the genetics of inbreeding. Because of their rich structure, the text focuses on discrete and continuous time Markov chains and continuous time and state Markov processes.New to the Second EditionA new chapter on stochastic differential equations th

  20. Biological isotopy. Introduction to the isotopic effects and to their applications in biology

    International Nuclear Information System (INIS)

    Since their discovery in the beginning of the 20. century, the study of stable isotopes has considerably developed. This domain, which remained limited in its applications until the 1990's, has become particularly important thereafter thanks to its practical applications and in particular to its economical impacts. Many techniques used in fraud control, in drugs use control, in selection of high-yield plants etc are based on isotopic abundance measurements. This reference book gives a synthesis of our actual knowledge on the use of stable isotopes and of isotope fractionation in biology. It presents the basic notions of isotopic biochemistry and explains the origin of the isotopic effects. The application principles of these effects to metabolism, to organisms physiology, to environmental biology etc are explained and detailed using examples and exercises. The first chapters present the basic knowledge which defines, from a mathematical point-of-view, the isotopic effects of chemical reactions or of physical processes taking place in biology. The measurements principle of natural isotopes abundance is then synthesised. Finally, all these notions are applied at different scales: enzymes, physiology, metabolism, environment, ecosystems and fraud crackdown. (J.S.)

  1. Applications of large-scale density functional theory in biology.

    Science.gov (United States)

    Cole, Daniel J; Hine, Nicholas D M

    2016-10-01

    Density functional theory (DFT) has become a routine tool for the computation of electronic structure in the physics, materials and chemistry fields. Yet the application of traditional DFT to problems in the biological sciences is hindered, to a large extent, by the unfavourable scaling of the computational effort with system size. Here, we review some of the major software and functionality advances that enable insightful electronic structure calculations to be performed on systems comprising many thousands of atoms. We describe some of the early applications of large-scale DFT to the computation of the electronic properties and structure of biomolecules, as well as to paradigmatic problems in enzymology, metalloproteins, photosynthesis and computer-aided drug design. With this review, we hope to demonstrate that first principles modelling of biological structure-function relationships are approaching a reality. PMID:27494095

  2. Research Applications of Proteolytic Enzymes in Molecular Biology

    Directory of Open Access Journals (Sweden)

    József Tőzsér

    2013-11-01

    Full Text Available Proteolytic enzymes (also termed peptidases, proteases and proteinases are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications require their use, including production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, cell culturing and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics and therapy, exploration of the structure-function relationships by structural studies, removal of affinity tags from fusion proteins in recombinant protein techniques, peptide sequencing and proteolytic digestion of proteins in proteomics. The aim of this paper is to review the molecular biological aspects of proteolytic enzymes and summarize their applications in the life sciences.

  3. Review of neutron radiographic applications in industrial and biological systems

    International Nuclear Information System (INIS)

    Neutron radiography is a non-destructive testing technique and is being used worldwide for the design and the development of reactor fuels for research and power reactors. It is also being used for non-destructive examination of nuclear industrial products. In addition to its explosives and other industrial sectors. In addition to its applications in industrial sectors, the technique is widely used for research and development activities in biological systems. A review of technical applications of neutron radiography in different fields particularly in nuclear fuel management, aerospace industry, explosives and biology is presented. The methodology of neutron radiography is also discussed in detail along with the advantages of the technique. In addition, the potential of the neutron radiography facility at PINSTECH has been described. (author)

  4. 1,2,4-triazine derivatives: Synthesis and biological applications

    Directory of Open Access Journals (Sweden)

    Mohammad Arshad

    2014-04-01

    Full Text Available 1,2,4-Triazines are the six membered heterocyclic compounds possessing three nitrogen in its structure with general formula C3H3N3. 1,2,4-Triazines and its derivatives have been found to exhibit the variety of biological applications such as antifungal, anti-HIV, anticancer, antiinflammatory, analgesic and antihypertensive, cardiotonic, neuroleptic, nootropic, antihistaminergic, tuberculostatic, antiviral, anti-protozoal, estrogen receptor modulators, antimalarial, cyclin-dependent kinase inhibitors, antimicrobial and antiparasitic activities.

  5. 1,2,4-triazine derivatives: Synthesis and biological applications

    OpenAIRE

    Mohammad Arshad; Taki Ahmed Khan; Meraj Alam Khan

    2014-01-01

    1,2,4-Triazines are the six membered heterocyclic compounds possessing three nitrogen in its structure with general formula C3H3N3. 1,2,4-Triazines and its derivatives have been found to exhibit the variety of biological applications such as antifungal, anti-HIV, anticancer, antiinflammatory, analgesic and antihypertensive, cardiotonic, neuroleptic, nootropic, antihistaminergic, tuberculostatic, antiviral, anti-protozoal, estrogen receptor modulators, antimalarial, cyclin-dependent kinase inh...

  6. Research Applications of Proteolytic Enzymes in Molecular Biology

    OpenAIRE

    József Tőzsér; János András Mótyán; Ferenc Tóth

    2013-01-01

    Proteolytic enzymes (also termed peptidases, proteases and proteinases) are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications ...

  7. Applications of electrochemistry and nanotechnology in biology and medicine II

    CERN Document Server

    Eliaz, Noam

    2011-01-01

    The study of electrochemical nanotechnology has emerged as researchers apply electrochemistry to nanoscience and nanotechnology. These two related volumes in the Modern Aspects of Electrochemistry Series review recent developments and breakthroughs in the specific application of electrochemistry and nanotechnology to biology and medicine. Internationally renowned experts contribute chapters that address both fundamental and practical aspects of several key emerging technologies in biomedicine, such as the processing of new biomaterials, biofunctionalization of surfaces, characterization of bio

  8. 9 CFR 114.7 - Personnel at licensed establishments.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Personnel at licensed establishments... REQUIREMENTS FOR BIOLOGICAL PRODUCTS § 114.7 Personnel at licensed establishments. (a) Each licensee shall...) All personnel employed in the preparation of biological products at a licensed establishment shall...

  9. Preparation and application of various nanoparticles in biology and medicine

    Directory of Open Access Journals (Sweden)

    Vardan Gasparyan

    2013-02-01

    Full Text Available The present paper considers prospects for application of various nanoparticles in biology and medicine. Here are presented data on preparation of gold and silver nanoparticles, and effects of shape of these nanoparticles on their optical properties. Application of these nanoparticles in diagnostics, for drug delivery and therapy, and preparation of magnetic nanoparticles from iron and cobalt salts are also discussed. Application of these nanoparticles as magnetic resonance imaging (MRI contrast agents and as vehicles for drug delivery, and preparation of quantum dots and their application as prospective nanoparticles for multiplex analysis and for visualization of cellular processes will be tackled. Finally, prospects for new types of nanocomposites (metallic nano-shells will be not overlooked.

  10. 78 FR 79506 - Tennessee Valley Authority: Exemption From Requirements To Revise Combined License Application To...

    Science.gov (United States)

    2013-12-30

    ... Health and Safety The underlying purpose of the enhancements to Emergency Preparedness found in 10 CFR... Address Enhancements to Emergency Preparedness Rules AGENCY: Nuclear Regulatory Commission. ACTION... the COL application, addressing the enhancements to the Emergency Preparedness (EP) rules by...

  11. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  12. Viability Assessment of a Repository at Yucca Mountain. Volume 4: License Application Plan and Costs

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-01

    defensible LA. Volume 4 is divided into seven sections. Section 2 presents a rationale and summary for the technical work to be done to develop the preclosure and postclosure safety cases that will support the compliance evaluations required for the evaluation of site suitability and for licensing. Section 2 also describes other necessary technical work, including that needed to support design decisions and development of the necessary design information. Section 3 presents a more detailed description of the technical work required to address the issues identified in Section 2. Section 3 also describes activities that will continue after submittal of the site recommendation and the LA. Examples include the drift scale heater test in the Exploratory Studies Facility (Section 3.1.4.3) and long-term waste package corrosion testing (Section 3.2.2.9). Section 4 discusses the statutory and regulatory framework for site recommendation and submittal of an LA, and describes the activities and documentation that must be completed to achieve these milestones, including the development of an EIS. Section 5 describes the numerous activities required to support program milestones, including support for completing the testing program, continuing tests as part of the performance confirmation program, and managing information and records to support regulatory and legal review. Sections 6 and 7 provide cost and schedule information for the activities planned.

  13. Laser-based micro/nanoengineering for biological applications

    Science.gov (United States)

    Stratakis, E.; Ranella, A.; Farsari, M.; Fotakis, C.

    2009-09-01

    Controlling the interactions of light with matter is crucial for the success and scalability for materials processing applications at micro and nano-scales. The use of ultrafast pulsed lasers (i.e. lasers emitting pulses of duration shorter than 10 -12 s) for the micro/nano engineering of biomaterials or materials relevant to biological applications opens up several exciting possibilities in this respect. These possibilities rely on several attractive features of ultrafast laser-matter interaction processes which allow nanoscale spatial resolution, non-thermal and non-destructive engineering to take place. This article presents a review of novel laser-based techniques for the printing and micro- and nano- scale surface modification of materials for biological applications. Emphasis is placed on techniques appropriate for biochip and tissue engineering applications, for which there is an increasing demand over the last years. Besides presenting recent advances achieved by these techniques, this work also delineates existing limitations and highlights emerging possibilities and future prospects in this field.

  14. Water-soluble perylenediimides: design concepts and biological applications.

    Science.gov (United States)

    Sun, Mengmeng; Müllen, Klaus; Yin, Meizhen

    2016-03-14

    Water-soluble perylenediimides (PDIs) with high fluorescence intensity, photostability and biocompatibility have been successfully prepared and applied in the biological field. In this tutorial review, we briefly focus on the synthetic strategies for the preparation of water-soluble PDIs by incorporating ionic or non-ionic substituents with multiple polar groups into the bay-region, imide- or ortho-positions of PDIs. These ionic/non-ionic substituents can suppress π-π aggregation and shield the inner perylene chromophores, thus contributing to the water solubility which is essential for biological applications. The optical properties, absorption and emission maxima above 500 nm, minimize the autofluorescence background of cells and provide access to imaging in living cells. The biological applications of water-soluble PDIs are discussed from simple (basic) to complex (advanced) processes, including biosensing in vitro studies, imaging and gene/drug delivering in living cells, tissues and the whole body. The promising future of designed multi-functional water-soluble PDIs will be highlighted in this review. PMID:26797049

  15. 77 FR 12829 - Alabama Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-03-02

    ..., turbine and generator bearing refurbishment, and related component upgrades. For the Bouldin Development... rehabilitation or replacement, greaseless gate stem bushings installation, turbine and generator bearing.... Description of Application: Alabama Power Company seeks approval to replace turbine units 1 and 4 at the...

  16. 75 FR 74703 - Duke Energy Carolinas, LLC; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2010-12-01

    ... Reference Room, located at 888 First Street, NE., Room 2A, Washington, DC 20426, or by calling (202) 502... in reference to this application must be accompanied by proof of service on all persons listed in the...Library'' link. Enter the docket number excluding the last three digits in the docket number field...

  17. 76 FR 76193 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2011-12-06

    ... Tube Failure (PWR).'' The primary loop components (e.g., reactor vessel, reactor internals, control rod drive housings, piping and supports, and reactor coolant pumps) remain within their applicable... rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve...

  18. 77 FR 74841 - Alabama Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-12-18

    ... may be filed electronically via the Internet. See, 18 CFR 385.2001(a)(1)(iii) and the instructions on... Family Restaurant, a fast food restaurant, a permit to use project lands and waters for the installation... locations would be for use by patrons who access the restaurant by boat. l. Locations of the Application:...

  19. 7 CFR 51.33 - Application to become a licensed inspector.

    Science.gov (United States)

    2010-01-01

    ... handwriting, and the application shall contain or be accompanied by: (a) A statement of present address, age... inspectors; and (d) Such other information as may be required by the Administrator. ... Section 51.33 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING...

  20. 77 FR 10491 - Progress Energy Carolinas, Inc.; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2012-02-22

    .... d. Applicant: Progress Energy Carolinas, Inc. e. Name of Project: Yadkin-Pee Dee Hydroelectric... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact information at the end of your comments. For assistance, please contact FERC Online Support at...

  1. 76 FR 28016 - Progress Energy Carolinas, Inc.; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2011-05-13

    ... 29, 2011. d. Applicant: Progress Energy Carolinas, Inc. e. Name of Project: Yadkin-Pee Dee Hydroelectric Project. f. Location: The Pee Dee River in Stanly County, North Carolina. g. Filed Pursuant to... include your name and contact information at the end of your comments. Please include the project...

  2. 75 FR 30807 - South Carolina Electric & Gas Company; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2010-06-02

    ... Project: Saluda Hydroelectric Project. f. Location: The project is located on the Saluda and Congaree Rivers in Lexington, Newberry, Richland, and Saluda Counties, South Carolina. The proposed action would.... Applicant Contact: Mr. Tommy Boozer, Manager, Lake Management Programs, SCE&G, 6248 Bush River...

  3. 75 FR 48962 - South Carolina Electric & Gas Company; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2010-08-12

    ... Project: Saluda Hydroelectric Project. f. Location: The project is located on the Saluda River in Lexington, Newberry, Richland, and Saluda counties, South Carolina. The proposed action would occur on Lake.... Applicant Contact: Mr. Tommy Boozer, Manager, Lake Management Programs, SCE&G, 6248 Bush River...

  4. 76 FR 53672 - South Carolina Electric & Gas Company; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2011-08-29

    ..., 2011. d. Applicant: South Carolina Electric & Gas Company. e. Name of Project: Saluda Hydroelectric Project. f. Location: The project is located on the Saluda River in Lexington, Newberry, Richland, and Saluda counties, South Carolina. The proposed action would occur on Lake Murray in Lexington...

  5. Compliance with applicable national environmental policy requirements for licensing a new nuclear power plant world-wide

    International Nuclear Information System (INIS)

    Assuring the protection of humans and their environment is of great concern to nuclear electric power generators and regulators, as we move towards a full scale nuclear renaissance. The applicable national environmental policies of the host country usually require government agencies and the permit applicants to consider environmental impacts in making decisions and to disclose these environmental impacts to the public. For licensing a new nuclear power plant, the applicant submits an Environmental Report (ER) or an equivalent report, Environmental Impact Assessment (EIA) to the local designated permitting agency for review. The ER/EIA provides the agency with a comprehensive description of the environmental baseline conditions, the probable impacts of the proposed project, and the potential mitigation and monitoring efforts. In general, the report supports the host country's goals of environmental protection and sustainable development; integrates environmental protection and economic decisions; predicts environmental, social, and economic consequences of the proposed activity and assesses plans to mitigate any adverse impacts resulting from the proposed activity; and provides for the involvement of government and other agencies in the review of the proposed activity. This paper covers issues concerning the evaluation of potential land use, water use, and ecological and socioeconomic impacts of a new nuclear power plant, as addressed in an ER/EIA. It specifically focuses on the evaluation and mitigation of potential cumulative impacts of new nuclear power plant construction and operation, and its alternative sites and plant systems. Case studies related to selection of plant systems based on local environmental site conditions, preferred compliance plan, and public acceptances are included. (author)

  6. Chitooligosaccharide and Its Derivatives: Preparation and Biological Applications

    Directory of Open Access Journals (Sweden)

    Gaurav Lodhi

    2014-01-01

    Full Text Available Chitin is a natural polysaccharide of major importance. This biopolymer is synthesized by an enormous number of living organisms; considering the amount of chitin produced annually in the world, it is the most abundant polymer after cellulose. The most important derivative of chitin is chitosan, obtained by partial deacetylation of chitin under alkaline conditions or by enzymatic hydrolysis. Chitin and chitosan are known to have important functional activities but poor solubility makes them difficult to use in food and biomedicinal applications. Chitooligosaccharides (COS are the degraded products of chitosan or chitin prepared by enzymatic or chemical hydrolysis of chitosan. The greater solubility and low viscosity of COS have attracted the interest of many researchers to utilize COS and their derivatives for various biomedical applications. In light of the recent interest in the biomedical applications of chitin, chitosan, and their derivatives, this review focuses on the preparation and biological activities of chitin, chitosan, COS, and their derivatives.

  7. Short-time multifractal analysis: application to biological signals

    International Nuclear Information System (INIS)

    Some signals obtained from biological systems evince a great complexity. Recently, new tools which allow the extraction of information from them have been proposed. In particular, multifractal analysis gives a quantification of the degree and distribution of irregularities in a signal. A possible approach for this analysis is the one based on wavelet leaders. In this work, the use of wavelet leader based multifractal analysis in short-time windows is proposed in order to analyze the evolution of the multifractal behavior of biological signals. In particular, applications of this technique to the detection of ischemic episodes in heart rate variability signals and to voice activity detection are examined. It is shown that the study of the time evolution of indexes obtained with the proposed new method gives useful information hidden in the signals.

  8. Classical and spatial stochastic processes with applications to biology

    CERN Document Server

    Schinazi, Rinaldo B

    2014-01-01

    The revised and expanded edition of this textbook presents the concepts and applications of random processes with the same illuminating simplicity as its first edition, but with the notable addition of substantial modern material on biological modeling. While still treating many important problems in fields such as engineering and mathematical physics, the book also focuses on the highly relevant topics of cancerous mutations, influenza evolution, drug resistance, and immune response. The models used elegantly apply various classical stochastic models presented earlier in the text, and exercises are included throughout to reinforce essential concepts. The second edition of Classical and Spatial Stochastic Processes is suitable as a textbook for courses in stochastic processes at the advanced-undergraduate and graduate levels, or as a self-study resource for researchers and practitioners in mathematics, engineering, physics, and mathematical biology. Reviews of the first edition: An appetizing textbook for a f...

  9. DNA confinement in nanochannels: physics and biological applications

    DEFF Research Database (Denmark)

    Reisner, Walter; Pedersen, Jonas Nyvold; Austin, Robert H

    2012-01-01

    biological interest in extracting linear sequence information from elongated DNA molecules, from a physics view these systems are fascinating as they enable probing of single-molecule conformation in environments with dimensions that intersect key physical length-scales in the 1 nm to 100μm range. (Some......DNA is the central storage molecule of genetic information in the cell, and reading that information is a central problem in biology. While sequencing technology has made enormous advances over the past decade, there is growing interest in platforms that can readout genetic information directly...... nanochannels, creating a linear unscrolling of the genome along the channel for analysis. We will first review the fundamental physics of DNA nanochannel confinement—including the effect of varying ionic strength—and then discuss recent applications of these systems to genomic mapping. Apart from the intense...

  10. Relationship of microdosimetric techniques to applications in biological systems

    International Nuclear Information System (INIS)

    Ionizing radiations are known to induce a wide variety of biological effects, including cell killing, mutation, chromosome aberrations, and carcinogenesis. Most effects of direct relevance to humans, whether from environmental, occupational, diagnostic, or therapeutic exposure, are due to damage to individual cells either singly or in multiples. It is clear that the microscopic patterns of interactions and energy deposition by the radiations are crucial to any detailed understanding of the mechanisms by which they induce these effects. All physical descriptions of these microscopic patterns constitute the field of microdosimetry in its broadest sense. This chapter summarizes the main descriptions which have been proposed to date and illustrates how they have been applied to biological systems. Limitations of the techniques and their applications are discussed

  11. Radioactive indicators in biology and their medical applications

    International Nuclear Information System (INIS)

    This talk was given at the society of promotion of the national industry on December 1, 1949. The report is a pre-print of an article published in L'Industrie Nationale no.2 (1950). It presents the state-of-the-art of the use of artificial radioisotopes in biology and medicine: 1 - definitions (isotopes, decay, radiation emission); 2 - modalities of the use of radioisotopes in biology: basic instrumentation (Geiger-Mueller counter, counting techniques, photography, auto-histo-radiography); 3 - applications in physiology (digestive absorption, excretion, vascular exchanges, tracer techniques) and biochemistry (metabolism, thyroxine synthesis and fixation indicators, tracer techniques for drugs); 4 - radiotherapy, internal and external irradiation. (J.S.)

  12. Synthetic glycopeptides and glycoproteins with applications in biological research

    Directory of Open Access Journals (Sweden)

    Ulrika Westerlind

    2012-05-01

    Full Text Available Over the past few years, synthetic methods for the preparation of complex glycopeptides have been drastically improved. The need for homogenous glycopeptides and glycoproteins with defined chemical structures to study diverse biological phenomena further enhances the development of methodologies. Selected recent advances in synthesis and applications, in which glycopeptides or glycoproteins serve as tools for biological studies, are reviewed. The importance of specific antibodies directed to the glycan part, as well as the peptide backbone has been realized during the development of synthetic glycopeptide-based anti-tumor vaccines. The fine-tuning of native chemical ligation (NCL, expressed protein ligation (EPL, and chemoenzymatic glycosylation techniques have all together enabled the synthesis of functional glycoproteins. The synthesis of structurally defined, complex glycopeptides or glyco-clusters presented on natural peptide backbones, or mimics thereof, offer further possibilities to study protein-binding events.

  13. Multiscale Model Simulations of Temperature and Relative Humidity for the License Application of the Proposed Yucca Mountain Repository

    Science.gov (United States)

    Buscheck, T.; Glascoe, L.; Sun, Y.; Gansemer, J.; Lee, K.

    2003-12-01

    ; these variables are determined every 20 m for each emplacement drift in the repository. The MSTHM accounts for 3-D drift-scale and mountain-scale heat flow and captures the influence of the key engineering-design variables and natural-system factors affecting TH conditions in the emplacement drifts and adjoining host rock. Presented is a synopsis of recent MSTHM calculations conducted to support the Total System Performance Assessment for the License Application (TSPA-LA). This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  14. Edwin I. Hatch Nuclear Plant, Unit 2. License application, general information

    International Nuclear Information System (INIS)

    An application for a direct cycle BWR is presented. The reactor will be located about 11 miles north of Baxley, Ga., near the south bank of the Ultamaha River in Appling County close to Hatch-1 Reactor. The core thermal power level will be 2537 MW(t) and the electrical power level will be 795 MW(e). Mechanical cooling towers will be utilized

  15. Black Fox Station, Units 1 and 2. Application for construction permits and operating licenses

    International Nuclear Information System (INIS)

    An application to construct and operate Black Fox Station, Units 1 and 2, is presented. The two BWR type reactors will have a rated core thermal power of 3579 MW(t) and a net electrical power of approximately 1150 MW(e). The facility will be located in Inola Township, 23 miles east of Tulsa on the east side of the Verdigris River in Rogers County, Oklahoma

  16. Marble Hill Nuclear Generating Station, Units 1 and 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    An application is presented for two PWR reactors to be constructed in Salud Township, Jefferson County, Indiana, about six miles northeast of New Washington on the Ohio River. Each unit will have a rated core power level of 3411 MW(t) with a corresponding electrical output of 1130 MW(e). Mechanical draft cooling towers will be provided. The facility, which will replicate the Byron facility will be employed for the generation of electricity for transmission, sale for resale, and distribution

  17. Environmental Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Environmental report

    International Nuclear Information System (INIS)

    The Environmental Standard Review Plan (ESRP) (NUREG-1300) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform environmental reviews of environmental reports prepared by applicants in support of license applications to construct and operate new low-level radioactive waste disposal facilities. The individual ESRPs that constitute this document identify the information considered necessary to conduct the review, the purpose and scope of the review, the analysis procedure and evaluation, the formal input to the environmental statement, and the references considered appropriate for each review. The ESRP is intended to ensure quality and uniformity of approach in individual reviews as well as compliance with the National Environmental Policy Act of 1969. In addition, the ESRP will make information about the environmental component of the licensing process more readily available and thereby will serve to improve the understanding of this process among the public, States and regional compacts, and the regulated community

  18. Pulsed electrical discharges for medicine and biology techniques, processes, applications

    CERN Document Server

    Kolikov, Victor

    2015-01-01

    This book presents the application of pulsed electrical discharges in water and water dispersions of metal nanoparticles in medicine (surgery, dentistry, and oncology), biology, and ecology. The intensive electrical and shock waves represent a novel technique to destroy viruses and this way to  prepare anti-virus vaccines. The method of pulsed electrical discharges in water allows to decontaminate water from almost all known bacteria and spores of fungi being present in human beings. The nanoparticles used are not genotoxic and mutagenic. This book is useful for researchers and graduate students.

  19. The application of nuclear localisation technologies in environmental biology

    International Nuclear Information System (INIS)

    Nuclear and related localisation technologies at ANSTO have been applied to a range biological matrices, in relation to specific environmental questions. Several of these applications are summarised, including the localization of lead and other elements in crocodile osteoderms and validation of bivalve shell micro-laminations as archival monitors of pollution signals. The co-location of Ca and its metabolic analogue Ra-226 led to further development of a theoretical model of bioaccumulation of alkaline-earth and other elements in the tissue of Australian freshwater bivalves under natural conditions, which were not appreciably altered by uranium mining in the region

  20. The Monticello license renewal project

    International Nuclear Information System (INIS)

    Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

  1. Applications of Chitin and Its Derivatives in Biological Medicine

    Directory of Open Access Journals (Sweden)

    Moon-Moo Kim

    2010-12-01

    Full Text Available Chitin and its derivatives—as a potential resource as well as multiple functional substrates—have generated attractive interest in various fields such as biomedical, pharmaceutical, food and environmental industries, since the first isolation of chitin in 1811. Moreover, chitosan and its chitooligosaccharides (COS are degraded products of chitin through enzymatic and acidic hydrolysis processes; and COS, in particular, is well suited for potential biological application, due to the biocompatibility and nontoxic nature of chitosan. In this review, we investigate the current bioactivities of chitin derivatives, which are all correlated with their biomedical properties. Several new and cutting edge insights here may provide a molecular basis for the mechanism of chitin, and hence may aid its use for medical and pharmaceutical applications.

  2. Micro-segmented flow applications in chemistry and biology

    CERN Document Server

    Cahill, Brian

    2014-01-01

    The book is dedicated to the method and application potential of micro segmented flow. The recent state of development of this powerful technique is presented in 12 chapters by leading researchers from different countries. In the first section, the principles of generation and manipulation of micro-fluidic segments are explained. In the second section, the micro continuous-flow synthesis of different types of nanomaterials is shown as a typical example for the use of advantages of the technique in chemistry. In the third part, the particular importance of the technique in biotechnical applications is presented demonstrating the progress for miniaturized cell-free processes, for molecular biology and DNA-based diagnostis and sequencing as well as for the development of antibiotics and the evaluation of toxic effects in medicine and environment.

  3. Streamlining the license renewal review process

    International Nuclear Information System (INIS)

    The staff of the NRC has been developing three regulatory guidance documents for license renewal: the Generic Aging Lessons Learned (GALL) report, Standard Review Plan for License Renewal (SRP-LR), and Regulatory Guide (RG) for Standard Format and Content for Applications to Renew Nuclear Power Plant Operating Licenses. These documents are designed to streamline the license renewal review process by providing clear guidance for license renewal applicants and the NRC staff in preparing and reviewing license renewal applications. The GALL report systematically catalogs aging effects on structures and components; identifies the relevant existing plant programs; and evaluates the existing programs against the attributes considered necessary for an aging management program to be acceptable for license renewal. The GALL report also provides guidance for the augmentation of existing plant programs for license renewal. The revised SRP-LR allows an applicant to reference the GALL report to preclude further NRC staff evaluation if the plant's existing programs meet the criteria described in the GALL report. During the review process, the NRC staff will focus primarily on existing programs that should be augmented or new programs developed specifically for license renewal. The Regulatory Guide is expected to endorse the Nuclear Energy Institute (NEI) guideline, NEI 95-10, Revision 2, entitled 'Industry Guideline for Implementing the Requirements of 10 CFR Part 54 - The License Renewal Rule', which provides guidance for preparing a license renewal application. This paper will provide an introduction to the GALL report, SRP-LR, Regulatory Guide, and NEI 95-10 to show how these documents are interrelated and how they will be used to streamline the license renewal review process. This topic will be of interest to domestic power utilities considering license renewal and international ICONE participants seeking state-of-the-art information about license renewal in the United States

  4. Core/Shell Structured Magnetic Nanoparticles for Biological Applications

    International Nuclear Information System (INIS)

    Magnetic nanoparticles have been widely used for biomedical applications, such as magnetic resonance imaging (MRI), hyperthermia, drug delivery and cell signaling. The surface modification of the nanomaterials is required for biomedical use to give physiogical stability, surface reactivity and targeting properties. Among many approaches for the surface modification with materials, such as polymers, organic ligands and metals, one of the most attractive ways is using metals. The fabrication of metal-based, monolayer-coated magnetic nanoparticles has been intensively studied. However, the synthesis of metal-capped magnetic nanoparticles with monodispersities and controllable sizes is still challenged. Recently, gold-capped magnetic nanoparticles have been reported to increase stability and to provide biocompatibility. Magnetic nanoparticle with gold coating is an attractive system, which can be stabilized in biological conditions and readily functionalized in biological conditions and readily functionalized through well-established surface modification (Au-S) chemistry. The Au coating offers plasmonic properties to magnetic nanoparticles. This makes the magnetic/Au core/shell combinations interesting for magnetic and optical applications. Herein, the synthesis and characterization of gold capped-magnetic core structured nanomaterials with different gold sources, such as gold acetate and chloroauric acid have been reported. The core/shell nanoparticles were transferred from organic to aqueous solutions for biomedical applications. Magnetic core/shell structured nanoparticles have been prepared and transferred from organic phase to aqueous solutions. The resulting Au-coated magnetic core nanoparticles might be an attractive system for biomedical applications, which are needed both magnetic resonance imaging and optical imaging

  5. 10 CFR 55.57 - Renewal of licenses.

    Science.gov (United States)

    2010-01-01

    ... Administrator specified in § 55.5(b). (3) Provide written evidence of the applicant's experience under the... 10 Energy 2 2010-01-01 2010-01-01 false Renewal of licenses. 55.57 Section 55.57 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Licenses § 55.57 Renewal of licenses. (a) The...

  6. 10 CFR 52.167 - Issuance of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Issuance of manufacturing license. 52.167 Section 52.167... POWER PLANTS Manufacturing Licenses § 52.167 Issuance of manufacturing license. (a) After completing any... manufacturing license if the Commission finds that: (1) Applicable standards and requirements of the Act and...

  7. 10 CFR 51.54 - Environmental report-manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-manufacturing license. 51.54 Section... report—manufacturing license. (a) Each applicant for a manufacturing license under subpart F of part 52... Environmental Report—Manufacturing License.” The environmental report must address the costs and benefits...

  8. 10 CFR 52.109 - Continuation of combined license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Continuation of combined license. 52.109 Section 52.109... POWER PLANTS Combined Licenses § 52.109 Continuation of combined license. Each combined license for a... applicable to the facility in accordance with the NRC's regulations and the provisions of the...

  9. Review on thin-film transistor technology, its applications, and possible new applications to biological cells

    Science.gov (United States)

    Tixier-Mita, Agnès; Ihida, Satoshi; Ségard, Bertrand-David; Cathcart, Grant A.; Takahashi, Takuya; Fujita, Hiroyuki; Toshiyoshi, Hiroshi

    2016-04-01

    This paper presents a review on state-of-the-art of thin-film transistor (TFT) technology and its wide range of applications, not only in liquid crystal displays (TFT-LCDs), but also in sensing devices. The history of the evolution of the technology is first given. Then the standard applications of TFT-LCDs, and X-ray detectors, followed by state-of-the-art applications in the field of chemical and biochemical sensing are presented. TFT technology allows the fabrication of dense arrays of independent and transparent microelectrodes on large glass substrates. The potential of these devices as electrical substrates for biological cell applications is then described. The possibility of using TFT array substrates as new tools for electrical experiments on biological cells has been investigated for the first time by our group. Dielectrophoresis experiments and impedance measurements on yeast cells are presented here. Their promising results open the door towards new applications of TFT technology.

  10. Clinch River Breeder Reactor Plant. License application, statement of general information

    International Nuclear Information System (INIS)

    Application is made for a reactor facility consisting of a liquid metal cooled reactor and steam generator system, a steam turbine driven electric generating system, electrical switchyard, and related auxiliaries and supporting structures. The primary system is located in an inert atmosphere in shielded vaults within a containment structure. Sodium coolant is used to remove heat from the core and radial blanket. Heat from the primary sodium is transferred in heat exchangers to non radioactive sodium which is used to convert feed-water into steam which is superheated to drive a tandem-compound generator. A single shaft multi-stage turbine generator produces 380 MW(e) with steam conditions of 1450 psig at 9000F. Fuel is sintered ceramic pellets of mixed uranium-plutonium oxides encapsulated in stainless steel. There are 198 fuel assemblies with each assembly consisting of 217 fuel rods placed in a hexagonal channel. Plutonium enrichment ranges from 1817 to 32.0 percent by weight. Axial blanket sections contain depleted UO2 with 99.8 percent 238U and 0.2 percent 235U by weight. The proposed location of the plant is within the corporate limits of the city of Oak Ridge in Roane County, Tennessee. (U.S.)

  11. Personality differences of applicants for the gun license (proprioceptive and verbal tests

    Directory of Open Access Journals (Sweden)

    Josep M. Tous

    2014-10-01

    Full Text Available The Proprioceptive Diagnosis of Temperament and Character (DP-TC test (Tous, 2008, which assesses fine motor performance without vision of one's own body, was used together with a verbal personality test (Durán, García, García, & Martínez, 2001 to examine personality differences between a group of gun licence (GL applicants and a group from the general population (GP. MANOVA results showed significant differences between the groups on the DP-TC test, with the GL group scoring higher on Emotionality (Temperament and Impulsivity (Temperament and Character and lower on Decision-Making (Temperament and Character and Mood (Temperament. In the GL group, fine motor performance on the DP-TC test was compared with the verbal test results by means of a principal components analysis with varimax rotation. The results corresponding to the Temperament dimensions of the DP-TC test showed only one association with the verbal test variables, thus corroborating the notion that Temperament has little social influence. Comparison of the proprioceptive and verbal tests showed that the results on the Emotionality scale of the DP-TC were consistent with those on the Ego-strength scale of the verbal personality test, but not with Neuroticism; this suggests that these subjects might fake their replies in order to obtain the gun licence.

  12. Ultrasensitive Force Detection and Applications to Biological Systems

    Science.gov (United States)

    Kenny, Thomas

    2001-03-01

    For many years, researchers have developed a variety of micromechanical devices for a range of applications. The majority of these devices are based on micromechanical force transducers to convert external physical signals into electrical signals. The force sensing capabilities of these devices are remarkable - it is possible to design devices with force resolution ranging from milli-N to atto-N within this technology. In addition to the conventional applications for MEMS devices, it is possible to tailor these designs to allow interesting scientific measurements on biological systems. For example, there are active research communities investigating cellular adhesion, protein folding, and animal locomotion. In all of these cases, the basic questions are mechanical in nature, and direct force measurements can provide new insight. This talk will review some ongoing biological research that makes use of MEMS devices, and discuss opportunities for new directions. Collaborators on this research include : Yiching Liang, Robert Rudnitsky, Michael Bartsch, Robert Full, Kellar Autumn, James Nelson, Jim Spudich, and Mark Cutkosky This work is funded by NSF (XYZ on a Chip) and ONR MURI (Biomimetic Robots).

  13. Advances in microbeam technologies and applications to radiation biology.

    Science.gov (United States)

    Barberet, P; Seznec, H

    2015-09-01

    Charged-particle microbeams (CPMs) allow the targeting of sub-cellular compartments with a counted number of energetic ions. While initially developed in the late 1990s to overcome the statistical fluctuation on the number of traversals per cell inevitably associated with broad beam irradiations, CPMs have generated a growing interest and are now used in a wide range of radiation biology studies. Besides the study of the low-dose cellular response that has prevailed in the applications of these facilities for many years, several new topics have appeared recently. By combining their ability to generate highly clustered damages in a micrometric volume with immunostaining or live-cell GFP labelling, a huge potential for monitoring radiation-induced DNA damage and repair has been introduced. This type of studies has pushed end-stations towards advanced fluorescence microscopy techniques, and several microbeam lines are currently equipped with the state-of-the-art time-lapse fluorescence imaging microscopes. In addition, CPMs are nowadays also used to irradiate multicellular models in a highly controlled way. This review presents the latest developments and applications of charged-particle microbeams to radiation biology. PMID:25911406

  14. Advanced carbon manufacturing for energy and biological applications

    Science.gov (United States)

    Turon Teixidor, Genis

    The science of miniaturization has experienced revolutionary advances during the last decades, witnessing the development of the Integrated Circuit and the emergence of MEMS and Nanotechnology. Particularly, MEMS technology has pioneered the use of non-traditional materials in microfabrication by including polymers, ceramics and composites to the well known list of metals and semiconductors. One of the latest additions to this set of materials is carbon, which represents a very important inclusion given its significance in electrochemical energy conversion systems and in applications where it is used as sensor probe material. For these applications, carbon is optimal in several counts: It has a wide electrochemical stability window, good electrical and thermal conductivity, high corrosion resistance and mechanical stability, and is available in high purity at a low cost. Furthermore carbon is biocompatible. This thesis presents several microfabricated devices that take advantage of these properties. The thesis has two clearly differentiated parts. In the first one, applications of micromachined carbon in the field of energy conversion and energy storage are presented. These applications include lithium ion micro batteries and the development of new carbon electrodes with fractal geometries. In the second part, the focus shifts to biological applications. First, the study of the interaction of living cells with micromachined carbon is presented, followed by the description of a sensor based on interdigitated nano-electrode arrays, and finally the development of the new instrumentation needed to address arrays of carbon electrodes, a multiplexed potentiostat. The underlying theme that connects all these seemingly different topics is the use of carbon microfabrication techniques in electrochemical systems.

  15. Characterization of freestanding photoresist films for biological and MEMS applications

    International Nuclear Information System (INIS)

    Photoresists are light-sensitive resins used in a variety of technological applications. In most applications, however, photoresists are generally used as sacrificial layers or a structural layer that remains on the fabrication substrate. Thin layers of patterned 1002F photoresist were fabricated and released to form a freestanding film. Films of thickness in the range of 4.5–250 µm were patterned with through-holes to a resolution of 5 µm and an aspect ratio of up to 6:1. Photoresist films could be reliably released from the substrate after a 12 h immersion in water. The Young's modulus of a 50 µm-thick film was 1.43 ± 0.20 GPa. Use of the films as stencils for patterning sputtered metal onto a surface was demonstrated. These 1002F stencils were used multiple times without deterioration in feature quality. Furthermore, the films provided biocompatible, transparent surfaces of low autofluorescence on which cells could be grown. Culture of cells on a film with an isolated small pore enabled a single cell to be accessed through the underlying channel and loaded with exogenous molecules independently of nearby cells. Thus 1002F photoresist was patterned into thin, flexible, free-standing films that will have numerous applications in the biological and MEMS fields. (paper)

  16. Biological applications of fluorescence lifetime imaging beyond microscopy

    Science.gov (United States)

    Akers, Walter J.; Berezin, Mikhail Y.; Lee, Hyeran; Guo, Kevin; Almutairi, Adah; Fréchet, Jean M. J.; Fischer, Georg M.; Daltrozzo, Ewald; Achilefu, Samuel

    2010-02-01

    Fluorescence lifetime is a relatively new contrast mechanism for optical imaging in living subjects that relies on intrinsic properties of fluorophores rather than concentration dependent intensity. Drawing upon the success of fluorescence lifetime imaging microscopy (FLIM) for investigation of protein-protein interactions and intracellular physiology, in vivo fluorescence lifetime imaging (FLI) promises to dramatically increase the utility of fluorescencebased imaging in preclinical and clinical applications. Intrinsic fluorescence lifetime measurements in living tissues can distinguish pathologies such as cancer from healthy tissue. Unfortunately, intrinsic FLT contrast is limited to superficial measurements. Conventional intensity-based agents have been reported for measuring these phenomena in vitro, but translation into living animals is difficult due to optical properties of tissues. For this reason, contrast agents that can be detected in the near infrared (NIR) wavelengths are being developed by our lab and others to enhance the capabilities of this modality. FLT is less affected by concentration and thus is better for detecting small changes in physiology, as long as sufficient fluorescence signal can be measured. FLT can also improve localization of signals for improved deep tissue imaging. Examples of the utility of exogenous contrast agents will be discussed, including applications in monitoring physiologic functions, controlled drug release and cancer biology. Instrumentation for FLI will also be discussed, including planar and diffuse optical imaging in time and frequency domains. Future applications will also be discussed that are being developed in this exciting field that complement other optical modalities.

  17. 10 CFR 52.8 - Combining licenses; elimination of repetition.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Combining licenses; elimination of repetition. 52.8... NUCLEAR POWER PLANTS General Provisions § 52.8 Combining licenses; elimination of repetition. (a) An applicant for a license under this part may combine in its application several applications for...

  18. Fluid Mechanics of Biological Surfaces and their Technological Application

    Science.gov (United States)

    Bechert, D. W.; Bruse, M.; Hage, W.; Meyer, R.

    A survey is given on fluid-dynamic effects caused by the structure and properties of biological surfaces. It is demonstrated that the results of investigations aiming at technological applications can also provide insights into biophysical phenomena. Techniques are described both for reducing wall shear stresses and for controlling boundary-layer separation. (a) Wall shear stress reduction was investigated experimentally for various riblet surfaces including a shark skin replica. The latter consists of 800 plastic model scales with compliant anchoring. Hairy surfaces are also considered, and surfaces in which the no-slip condition is modified. Self-cleaning surfaces such as that of lotus leaves represent an interesting option to avoid fluid-dynamic deterioration by the agglomeration of dirt. An example of technological implementation is discussed for riblets in long-range commercial aircraft. (b) Separation control is also an important issue in biology. After a few brief comments on vortex generators, the mechanism of separation control by bird feathers is described in detail. Self-activated movable flaps (=artificial bird feathers) represent a high-lift system enhancing the maximum lift of airfoils by about 20%. This is achieved without perceivable deleterious effects under cruise conditions. Finally, flight experiments on an aircraft with laminar wing and movable flaps are presented.

  19. Atomic Force Microscopy Application in Biological Research: A Review Study

    Directory of Open Access Journals (Sweden)

    Surena Vahabi

    2013-06-01

    Full Text Available Atomic force microscopy (AFM is a three-dimensional topographic technique with a high atomic resolution to measure surface roughness. AFM is a kind of scanning probe microscope, and its near-field technique is based on the interaction between a sharp tip and the atoms of the sample surface. There are several methods and many ways to modify the tip of the AFM to investigate surface properties, including measuring friction, adhesion forces and viscoelastic properties as well as determining the Young modulus and imaging magnetic or electrostatic properties. The AFM technique can analyze any kind of samples such as polymers, adsorbed molecules, films or fibers, and powders in the air whether in a controlled atmosphere or in a liquid medium. In the past decade, the AFM has emerged as a powerful tool to obtain the nanostructural details and biomechanical properties of biological samples, including biomolecules and cells. The AFM applications, techniques, and -in particular- its ability to measure forces, are not still familiar to most clinicians. This paper reviews the literature on the main principles of the AFM modality and highlights the advantages of this technique in biology, medicine, and- especially- dentistry. This literature review was performed through E-resources, including Science Direct, PubMed, Blackwell Synergy, Embase, Elsevier, and Scholar Google for the references published between 1985 and 2010.

  20. A poroelastic immersed boundary method with applications to cell biology

    Science.gov (United States)

    Strychalski, Wanda; Copos, Calina A.; Lewis, Owen L.; Guy, Robert D.

    2015-02-01

    The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In the traditional immersed boundary method, the fluid and structure move with the same velocity field. In this work, a model based on the immersed boundary method is presented for simulating poroelastic media in which the fluid permeates a porous, elastic structure of small volume fraction that moves with its own velocity field. Two distinct methods for calculating elastic stresses are presented and compared. The methods are validated on a radially symmetric test problem by comparing with a finite difference solution of the classical equations of poroelasticity. Finally, two applications of the modeling framework to cell biology are provided: cellular blebbing and cell crawling. It is shown that in both examples, poroelastic effects are necessary to explain the relevant mechanics.

  1. Modular Verification of Interactive Systems with an Application to Biology

    Directory of Open Access Journals (Sweden)

    P. Milazzo

    2011-01-01

    Full Text Available We propose sync-programs, an automata-based formalism for the description of biological systems, and a modular verification technique for such a formalism that allows properties expressed in the universal fragment of CTL to be verified on suitably chosen fragments of models, rather than on whole models. As an application we show the modelling of the lac operon regulation process and the modular verification of some properties. Verification of properties is performed by using the NuSMV model checker and we show that by applying our modular verification technique we can verify properties in shorter times than those necessary to verify the same properties in the whole model.

  2. Biology and Industrial Applications of Chlorella: Advances and Prospects.

    Science.gov (United States)

    Liu, Jin; Chen, Feng

    2016-01-01

    Chlorella represents a group of eukaryotic green microalgae that has been receiving increasing scientific and commercial interest. It possesses high photosynthetic ability and is capable of growing robustly under mixotrophic and heterotrophic conditions as well. Chlorella has long been considered as a source of protein and is now industrially produced for human food and animal feed. Chlorella is also rich in oil, an ideal feedstock for biofuels. The exploration of biofuel production by Chlorella is underway. Chlorella has the ability to fix carbon dioxide efficiently and to remove nutrients of nitrogen and phosphorous, making it a good candidate for greenhouse gas biomitigation and wastewater bioremediation. In addition, Chlorella shows potential as an alternative expression host for recombinant protein production, though challenges remain to be addressed. Currently, omics analyses of certain Chlorella strains are being performed, which will help to unravel the biological implications of Chlorella and facilitate the future exploration of industrial applications. PMID:25537445

  3. Various On-Chip Sensors with Microfluidics for Biological Applications

    Directory of Open Access Journals (Sweden)

    Hun Lee

    2014-09-01

    Full Text Available In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR and surface-enhanced Raman scattering (SERS to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV and greater depth of field (DOF. As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

  4. Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns

    OpenAIRE

    König, Harald; Frank, Daniel; Heil, Reinhard; Coenen, Christopher

    2013-01-01

    New organisms and biological systems designed to satisfy human needs are among the aims of synthetic genomics and synthetic biology. Synthetic biology seeks to model and construct biological components, functions and organisms that do not exist in nature or to redesign existing biological systems to perform new functions. Synthetic genomics, on the other hand, encompasses technologies for the generation of chemically-synthesized whole genomes or larger parts of genomes, allowing to simultaneo...

  5. A novel POSS-coated quantum dot for biological application

    Directory of Open Access Journals (Sweden)

    Rizvi SB

    2012-08-01

    Full Text Available Sarwat B Rizvi,1 Lara Yildirimer,1 Shirin Ghaderi,1 Bala Ramesh,1 Alexander M Seifalian,1,2 Mo Keshtgar1,21UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, United Kingdom; 2Royal Free Hampstead NHS Trust Hospital, London, United KingdomAbstract: Quantum dots (QDs are fluorescent semiconductor nanocrystals that have the potential for major advancements in the field of nanomedicine through their unique photophysical properties. They can potentially be used as fluorescent probes for various biomedical imaging applications, including cancer localization, detection of micrometastasis, image guided surgery, and targeted drug delivery. Their main limitation is toxicity, which requires a biologically compatible surface coating to shield the toxic core from the surrounding environment. However, this leads to an increase in QD size that may lead to problems of excretion and systemic sequestration. We describe a one pot synthesis, characterization, and in vitro cytotoxicity of a novel polyhedral oligomeric silsesquioxane (POSS-coated CdTe-cored QD using mercaptosuccinic acid (MSA and D-cysteine as stabilizing agents. Characterization was performed using transmission electron microscopy Fourier transform infrared spectroscopy, and photoluminescence studies. POSS-coated QDs demonstrated high colloidal stability and enhanced photostability on high degrees of ultraviolet (UV excitation compared to QDs coated with MSA and D-cysteine alone (P value < 0.05. In vitro toxicity studies showed that both POSS and MSA-QDs were significantly less toxic than ionized salts of Cd+2 and Te-2. Confocal microscopy confirmed high brightness of POSS-QDs in cells at both 1 and 24 hours, indicating that these QDs are rapidly taken up by cells and remain photostable in a biological environment. We therefore conclude that a POSS coating confers biological compatibility, photostability, and colloidal

  6. 75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2010-08-20

    ... Energy Regulatory Commission Erie Boulevard Hydropower, L.P.; Notice of Intent To File License..., 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e. Name of Project: Chasm Hydroelectric Project....gov . j. Erie Boulevard Hydropower, L.P. (Erie) filed its request to use the Traditional...

  7. 77 FR 62500 - Peabody Trout Creek Reservoir LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-10-15

    ... Energy Regulatory Commission Peabody Trout Creek Reservoir LLC; Notice of Intent To File License...: Peabody Trout Creek Reservoir LLC. e. Name of Project: Trout Creek Reservoir Hydroelectric Project. f. Location: On Trout Creek, 15 miles southwest of Steamboat Springs, Colorado. The project occupies 4.3...

  8. 77 FR 60419 - Lock + Hydro Friends Fund XIX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-10-03

    ... Energy Regulatory Commission Lock + Hydro Friends Fund XIX, LLC; Notice of Intent To File License... Friends Fund XIX, LLC. e. Name of Project: Claiborne Hydroelectric Project. f. Location: At the U.S. Army... email at rachel.mcnamara@ferc.gov . j. Lock + Hydro Friends Fund XIX, LLC filed its request to use...

  9. 77 FR 16217 - Lock+ Hydro Friends Fund XXXIX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-03-20

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XXXIX, LLC; Notice of Intent To File License... Friends Fund XXXIX, LLC. e. Name of Project: C.W. Bill Young Lock and Dam Hydroelectric Project. f... R. Stover, Lock+\\TM\\ Hydro Friends Fund XXXIX, c/o Hydro Green Energy, LLC, 900 Oakmont Lane,...

  10. 77 FR 9222 - Lock+ Hydro Friends Fund XLII, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-02-16

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XLII, LLC; Notice of Intent To File License... Friends Fund XLII, LLC. e. Name of Project: Braddock Locks and Dam Hydroelectric Project. f. Location: At..., Lock+\\TM\\ Hydro Friends Fund XLII, c/o Hydro Green Energy, LLC, 900 Oakmont Lane, Suite 310,...

  11. 77 FR 16216 - Lock+ Hydro Friends Fund XLVI, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-03-20

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XLVI, LLC; Notice of Intent To File License... Friends Fund XLVI, LLC. e. Name of Project: Hildebrand Lock and Dam Hydroelectric Project. f. Location: At... R. Stover, Lock+\\TM\\ Hydro Friends Fund XLVI, c/o Hydro Green Energy, LLC, 900 Oakmont Lane,...

  12. Licensing and Business Models

    OpenAIRE

    Onetti Alberto; Verma Sameer

    2008-01-01

    License affects software companies’ business activities. While proprietary software vendors create custom licenses, open source companies have less flexibility. The Open Source Initiative (OSI) defines a list of 72 licenses as open source (“OSI approved”). For a project to follow open source licensing, it has to pick licenses from this set. Logically, we expect that an open source company defines its business model around the license that it selects. Thus, we can assume that business model de...

  13. Lessons learned from the licensing process and the operational performance of the important to safety digital application implemented at the Mexican nuclear facilities

    International Nuclear Information System (INIS)

    This paper describes the main concerns detected during the licensing processes performed by the Mexican Nuclear Regulatory Commission (CNSNS) for the NUMAC-PRNM, the Integrated Computer Systems at the Laguna Verde Nuclear Power Station (LVNPS) and for the Digital Control Console of the Triga Mark III Research Reactor (TMRR). The review and approval process was performed following the guidelines of the US Nuclear Regulatory Commission (USNRC); the regulatory frame applied includes the Code of Federal Regulation (10CFR50), some Regulatory Guides, such as: RG 1.152, RG 1.153, some Industrial Standards, for example: IEEE-279, IEEE-603, IEEE-7.4.3-2. Also, based on the operational experience taken from the LVNPS License Event Report (LER) reported under the 10CFR50.72 and 10CFR50.73 USNRC rules, and from the Report of Events to be Analyzed (REA) issued for a CNSNS agreement with the utility stated by the necessity to determine failure rates of digital equipment, some case studies and a preliminary failure cause classification is shown. The Event Report evaluation covered topics related to the software, hardware and firmware issues. Finally, the lessons learned from the licensing assessments and from the operational experience of the digital applications implemented are presented. It will also give the regulatory activities related to an IAEA international cooperation project on I and C digital upgrade concerns. (author)

  14. Nursing: Licensed Practical and Licensed Vocational Nurses

    Science.gov (United States)

    ... LPNs) and licensed vocational nurses (LVNs) provide basic nursing care. They work under the direction of registered ... licensed vocational nurses work in many settings, including nursing homes and extended care facilities, hospitals, physicians’ offices, ...

  15. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  16. Applications of dynamical systems to economical and biological sciences

    OpenAIRE

    Ferreira, Luís Miguel Mesquita da Silva

    2010-01-01

    Tese de doutoramento em Ciências (ramo de conhecimento em Matemática) In this PhD thesis, several concepts of distinct areas of Mathematics, such as Dynamical Systems, Game Theory and Statistics are applied to Economical and Biomedical Sciences. The Patent Licensing is studied in a Cournot competition framework, the General Equilibrium Theory is approached in terms of Edgeworthian economies and the subject of Immunology is covered through models with Regulatory T cells. C...

  17. Polyhydroyalkanoates: from Basic Research and Molecular Biology to Application

    Directory of Open Access Journals (Sweden)

    Amro Abd alFattah Amara

    2010-09-01

    Full Text Available This review describes the Polyhydroxyalkanoate (PHA, an intracellular biodegradable microbial polymer. PHAs is formed from different types of three hydroxyalkanoic acids monomers, each unit forms an ester bond with the hydroxyl group of the other one and the hydroxyl substituted carbon has R configuration. The C-3 atom in β position is branched with at least one carbon atom in the form of methyl group (C1 to thirteen carbons in the form of tridecyl (C13. This alkyl side chain is not necessarily saturated. PHAs are biosynthesized through regulated pathways by specific enzymes. PHAs are accumulated in bacterial cells from soluble to insoluble form as storage materials inside the inclusion bodies during unbalanced nutrition or to save organisms from reducing equivalents. PHAs are converted again to soluble components by PHAs depolymerases and the degraded materials enter various metabolic pathways. Until now, four classes of enzymes responsible for PHAs polymerization are known. PHAs were well studied regarding their promising applications, physical, chemical and biological properties. PHAs are biodegradable, biocompatible, have good material properties, renewable and can be used in many applications. The most limiting factor in PHAs commercialization is their high cost compared to the petroleum plastics. This review highlights the new knowledge and that established by the pioneers in this field as well as the factors, which affect PHAs commercialization.

  18. Functionalized nanoparticles for biological imaging and detection applications

    Science.gov (United States)

    Mei, Bing C.

    Semiconductor quantum dots (QDs) and gold nanoparticles (AuNPs) have gained tremendous attention in the last decade as a result of their size-dependent spectroscopic properties. These nanoparticles have been a subject of intense study to bridge the gap between macroscopic and atomic behavior, as well as to generate new materials for novel applications in therapeutics, biological sensing, light emitting devices, microelectronics, lasers, and solar cells. One of the most promising areas for the use of these nanoparticles is in biotechnology, where their size-dependent optical properties are harnessed for imaging and sensing applications. However, these nanoparticles, as synthesized, are often not stable in aqueous media and lack simple and reliable means of covalently linking to biomolecules. The focus of this work is to advance the progress of these nanomaterials for biotechnology by synthesizing them, characterizing their optical properties and rendering them water-soluble and functional while maintaining their coveted optical properties. QDs were synthesized by an organometallic chemical procedure that utilizes coordinating solvents to provide brightly luminescent nanoparticles. The optical interactions of these QDs were studied as a function of concentration to identify particle size-dependent optimal concentrations, where scattering and indirection excitation are minimized and the amount light observed per particle is maximized. Both QDs and AuNPs were rendered water-soluble and stable in a broad range of biologically relevant conditions by using a series of ligands composed of dihydrolipoic acid (DHLA) appended to poly(ethylene glycol) methyl ether. By studying the stability of the surface modified AuNPs, we revealed some interesting information regarding the role of the surface ligand on the nanoparticle stability (i.e. solubility in high salt concentration, resistance to dithiothreitol competition and cyanide decomposition). Furthermore, the nanoparticles

  19. Dielectric relaxation in biological systems physical principles, methods, and applications

    CERN Document Server

    Feldman, Yuri

    2015-01-01

    This title covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems.

  20. RNA triplexes: from structural principles to biological and biotech applications.

    Science.gov (United States)

    Devi, Gitali; Zhou, Yuan; Zhong, Zhensheng; Toh, Desiree-Faye Kaixin; Chen, Gang

    2015-01-01

    The diverse biological functions of RNA are determined by the complex structures of RNA stabilized by both secondary and tertiary interactions. An RNA triplex is an important tertiary structure motif that is found in many pseudoknots and other structured RNAs. A triplex structure usually forms through tertiary interactions in the major or minor groove of a Watson-Crick base-paired stem. A major-groove RNA triplex structure is stable in isolation by forming consecutive major-groove base triples such as U·A-U and C(+) ·G-C. Minor-groove RNA triplexes, e.g., A-minor motif triplexes, are found in almost all large structured RNAs. As double-stranded RNA stem regions are often involved in biologically important tertiary triplex structure formation and protein binding, the ability to sequence specifically target any desired RNA duplexes by triplex formation would have great potential for biomedical applications. Programmable chemically modified triplex-forming oligonucleotides (TFOs) and triplex-forming peptide nucleic acids (PNAs) have been developed to form TFO·RNA2 and PNA·RNA2 triplexes, respectively, with enhanced binding affinity and sequence specificity at physiological conditions. Here, we (1) provide an overview of naturally occurring RNA triplexes, (2) summarize the experimental methods for studying triplexes, and (3) review the development of TFOs and triplex-forming PNAs for targeting an HIV-1 ribosomal frameshift-inducing RNA, a bacterial ribosomal A-site RNA, and a human microRNA hairpin precursor, and for inhibiting the RNA-protein interactions involving human RNA-dependent protein kinase and HIV-1 viral protein Rev. PMID:25146348

  1. Application of fish biology in management of the fisheries

    OpenAIRE

    Mbabazi, D.; Namulemo, G.

    2001-01-01

    All biological aspects of the stock are of scientific interest. Specific biological parameters are used either in estimating; yield, or providing a basis for suggesting fisheries management strategies, growth, mortality and stock size are the main determinants of yield, and aspects such as the timing of spawning and recruitment are important in considering management measures. In fisheries science, fish biology contributes in two broad areas; a) Basic biology and distribution of resourc...

  2. Texas site selection and licensing status

    Energy Technology Data Exchange (ETDEWEB)

    Avant, R.V. Jr.

    1989-11-01

    Texas has identified a potential site in Hudspeth County in far West Texas near the town of Fort Hancock. Over the past year the Texas Low-Level Radioactive Waste Disposal Authority has been conducting detailed geology, hydrology, meteorology, soils, and flora and fauna evaluations. An authorization by the Board of Directors of the Authority to proceed with a license application, assuming that the detailed evaluation indicates that the site is suitable, is expected by September. A prototype license has been prepared in anticipation of the order to proceed with licensing, and the formal license application is expected to be submitted to the Texas Department of Health-Bureau of Radiation Control in December, meeting the license application milestone. Although site selection processes in all siting areas across the country have experienced organized opposition, El Paso County has funded a particularly well-organized, well-financed program to legally and technically stop consideration of the Fort Hancock site prior to the licensing process. Many procedural, regulatory, and technical issues have been raised which have required responses from the Authority in order to proceed with licensing. This has provided a unique perspective of what to expect from well-organized opposition at the licensing stage. This paper presents an update on the Texas siting activity with detailed information on the site evaluation and license application. Experience of dealing with issues raised by opposition relating to NRC guidelines and rules is also discussed.

  3. A review on biological adaptation: with applications in engineering science

    OpenAIRE

    LiMin Luo; WenJun Zhang

    2014-01-01

    Biological adaptation refers to that organisms change themselves at morphological, physiological, behavioral and molecular level to better survive in a changing environment. It includes phenotype adaptation and molecular adaptation. Biological adaptation is a driving force of evolution. Biological adaptation was described from Darwinian theory of evolution to the theory of molecular evolution in present paper. Adaptive control and adaptive filtering were briefly described also.

  4. Generic evaluation of feedwater transients and small break loss-of-coolant accidents in GE-designed operating plants and near-term operating license applications

    International Nuclear Information System (INIS)

    The results are presented of a generic evaluation of feedwater transients, small-break loss-of-coolant accidents (LOCAs), and other TMI-2-related events for General Electric Company (GE)-designed operating plants and near-term operating license applications to confirm or establish the bases for the continued safe operation of the operating plants. The results of this evaluation are presented in this report in the form of a set of findings and recommendations in each of the principal review areas. Additional review of the accident is continuing and further information is being obtained and evaluated. Any new information will be reviewed and modifications will be made as appropriate

  5. 75 FR 7469 - Panel Member List for Hydropower Licensing Study Dispute Resolution; Notice Extending Filing Date...

    Science.gov (United States)

    2010-02-19

    ... Energy Regulatory Commission Panel Member List for Hydropower Licensing Study Dispute Resolution; Notice Extending Filing Date for Applications for Panel Member List for Hydropower Licensing Study Dispute... in the Commission's hydropower integrated licensing process (ILP) study dispute resolution...

  6. Licensing an assured isolation facility for low-level radioactive waste. Volume 1: Licensing strategy and issues

    International Nuclear Information System (INIS)

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  7. 10 CFR 110.42 - Export licensing criteria.

    Science.gov (United States)

    2010-01-01

    ... NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Review of License Applications § 110.42 Export licensing criteria. (a) The review of license applications for export... nonproliferation objectives or otherwise jeopardize the common defense and security, in which case the...

  8. Application of biological dural graft made by meninges from porkers

    Institute of Scientific and Technical Information of China (English)

    Peng Liu; Shengping Huang; Songtao Qi

    2007-01-01

    BACKGROUND: Presently, over 40 kinds of dural grafts have been successively used in clinic. Among them, lyophilized human dura mater with good histocompatibility and less complications is applied most widely. But there are a few reports on cases of infected spongiform encephalopathy following application of lyodura. More ideal repair materials deserve to be further investigated.OBJECTIVE: To investigate the efficiency and safety of biological dural graft made by meninges from porkers to repair meningeal injury.DESIGN: A self-control observation.SETTING: Wuhan General Hospital of Guangzhou Military Area Command of Chinese PLA.MATERIALS: Sixteen New Zealand Rabbits, of either gender, weighing from 2 to 3 kg, of clean grade Ⅱ,with the age of 0.5 - 1 year, were involved in this experiment. The involved rabbits were provided by the Animal Experimental Center of the First Military Medical University of Chinese PLA. Biological surgical patch (dural graft) was developed by Guangdong Guanhao Biotechnological Co.,Ltd. It was processed by using meninges from porkers by tissue engineering technology.METHODS: This experiment was carried out in the Experimental Center of the 157 Hospital of Chinese PLA between December 2003 and June 2004. ① The experimental rabbits were anesthetized. Dura mater was exposed from two sides ofpostmedial line of coronal suture. A rectangular dura mater about 8 mm × 8mm in size was cut off. Then a biological surgical patch (dural graft) was sheared into insert with 8 mm diameter and sutured. The left dura mater was untouched and used as control. Scalp was sutured, and postoperative wound healing and recovery were observed. ②The anesthetized rabbits were sacrificed at postoperative 3, 14, 30 and 90 days, 4 rabbits once. The whole head was cut off, and its scalp was removed.Afterwards, the head was fixed by formalin. Tissues in operative site were obtained, performed routine paraffin embedding, sliced and conducted HE staining, finally, the

  9. Laser heating of dielectric particles for medical and biological applications.

    Science.gov (United States)

    Tribelsky, Michael I; Fukumoto, Yasuhide

    2016-07-01

    We consider the general problem of laser pulse heating of a spherical dielectric particle embedded in a liquid. The discussed range of the problem parameters is typical for medical and biological applications. We focus on the case, when the heat diffusivity in the particle is of the same order of magnitude as that in the fluid. We perform quantitative analysis of the heat transfer equation based on interplay of four characteristic scales of the problem, namely the particle radius, the characteristic depth of light absorption in the material of the particle and the two heat diffusion lengths: in the particle and in the embedding liquid. A new quantitative characteristic of the laser action, that is the cooling time, describing the temporal scale of the cooling down of the particle after the laser pulse is over, is introduced and discussed. Simple analytical formulas for the temperature rise in the center of the particle and at its surface as well as for the cooling time are obtained. We show that at the appropriate choice of the problem parameters the cooling time may be by many orders of magnitude larger the laser pulse duration. It makes possible to minimize the undesirable damage of healthy tissues owing to the finite size of the laser beam and scattering of the laser radiation, simultaneously keeping the total hyperthermia period large enough to kill the pathogenic cells. An example of application of the developed approach to optimization of the therapeutic effect at the laser heating of particles for cancer therapy is presented. PMID:27446706

  10. Stochastic daily solar irradiance for biological modeling applications

    International Nuclear Information System (INIS)

    Stochastic daily weather generators commonly used for biological modeling applications do not adequately reproduce empirical distributions of global solar irradiance. The daily clearness index, the ratio of daily global-to-extraterrestrial irradiance, captures the stochastic component of solar irradiance due to atmospheric conditions. Three alternative models of daily solar irradiance (truncated Gaussian distributions, a proposed modification based on logit-transformed relative clearness, and a family of empirically derived distributions) conditioned on the occurrence of rain are described and evaluated using data from 10 U.S. locations. These models are presented in terms of monthly cumulative distributions and density functions of clearness. Strong non-normality of distributions of clearness, and improved fits obtained with a logit transformation, are demonstrated. The proposed model, based on a logit transformation of relative clearness, was superior to the other two in terms of Akaike's information criterion, and generally superior to the standard model based on truncated Gaussian distributions in terms of goodness of fit between observed and generated irradiances. Based on this evidence, the proposed model is recommended for stochastic generation of daily irradiance conditioned on daily rainfall occurrence and temperature extremes. (author)

  11. Foamy Virus Biology and Its Application for Vector Development

    Directory of Open Access Journals (Sweden)

    Axel Rethwilm

    2011-05-01

    Full Text Available Spuma- or foamy viruses (FV, endemic in most non-human primates, cats, cattle and horses, comprise a special type of retrovirus that has developed a replication strategy combining features of both retroviruses and hepadnaviruses. Unique features of FVs include an apparent apathogenicity in natural hosts as well as zoonotically infected humans, a reverse transcription of the packaged viral RNA genome late during viral replication resulting in an infectious DNA genome in released FV particles and a special particle release strategy depending capsid and glycoprotein coexpression and specific interaction between both components. In addition, particular features with respect to the integration profile into the host genomic DNA discriminate FV from orthoretroviruses. It appears that some inherent properties of FV vectors set them favorably apart from orthoretroviral vectors and ask for additional basic research on the viruses as well as on the application in Gene Therapy. This review will summarize the current knowledge of FV biology and the development as a gene transfer system.

  12. Global optimization in systems biology: stochastic methods and their applications

    OpenAIRE

    Balsa-Canto, Eva; Banga, Julio R.; Egea, José A.; Villaverde, A. F.; Hijas-Liste, G. M.

    2012-01-01

    Mathematical optimization is at the core of many problems in systems biology: (1) as the underlying hypothesis for model development, (2) in model identification, or (3) in the computation of optimal stimulation procedures to synthetically achieve a desired biological behavior. These problems are usually formulated as nonlinear programing problems (NLPs) with dynamic and algebraic constraints. However the nonlinear and highly constrained nature of systems biology models, together with the usu...

  13. Overview of the Yucca Mountain Licensing Process

    International Nuclear Information System (INIS)

    This paper presents an overview of the licensing process for a Yucca Mountain repository for high-level radioactive waste and spent nuclear fuel. The paper discusses the steps in the licensing proceeding, the roles of the participants, the licensing and hearing requirements contained in the Code of Federal Regulations. A description of the Nuclear Regulatory Commission (NRC) staff acceptance and compliance reviews of the Department of Energy (DOE) application for a construction authorization and a license to receive and possess high-level radioactive waste and spent nuclear fuel is provided. The paper also includes a detailed description of the hearing process

  14. Biological effects of neutrons, mechanisms and applications; Effets biologiques des neutrons: mecanismes et applications

    Energy Technology Data Exchange (ETDEWEB)

    Voisin, Ph. [CEA/Fontenay-aux-Roses, Inst. de Protection et de Surete Nucleaire (IPSN), 92 (France)

    1999-12-01

    The interest to study the ionizing radiations effects on the biological structures concern not only the fundamental comprehension of the mechanisms leading to the radiation damage but also much more pragmatic problems such as the accidental overexposure or radiotherapy treatment. Among these fundamental or applied studies, the neutrons effects take an important part, because of their particular mode of indirect ionization effect and their applications, as well civil as military ones. The purpose of this review is to point out some specific biological effects of neutrons and to describe biological methods to measure them. It clearly appears that neutrons biological effects are more deleterious than those caused by the radiations of lower TEL(X- and {gamma}-rays) taken as reference, for all the measurement levels used, genes mutations, chromosome aberrations, cellular survival or carcinogenesis. This difference is probably related to the density of the energy deposit in the vital cell targets, and to the absence of significant variations related to oxygenation, dose rate or dose fractionation. Such toxic effects, when considered in the course of a criticality accident, can paradoxically become an advantage in the follow-up of therapeutic treatment. (author)

  15. Molecular biology techniques and applications for ocean sensing

    Directory of Open Access Journals (Sweden)

    J. P. Zehr

    2008-11-01

    Full Text Available The study of marine microorganisms using molecular biological techniques is now widespread in the ocean sciences. These techniques target nucleic acids which record the evolutionary history of microbes, and encode for processes which are active in the ocean today. Here we review some of the most commonly used molecular biological techniques. Molecular biological techniques permit study of the abundance, distribution, diversity, and physiology of microorganisms in situ. These techniques include the polymerase chain reaction (PCR and reverse-transcriptase PCR, quantitative PCR, whole assemblage "fingerprinting" approaches (based on nucleic acid sequence or length heterogeneity, oligonucleotide microarrays, and high-throughput shotgun sequencing of whole genomes and gene transcripts, which can be used to answer biological, ecological, evolutionary and biogeochemical questions in the ocean sciences. Moreover, molecular biological approaches may be deployed on ocean sensor platforms and hold promise for tracking of organisms or processes of interest in near-real time.

  16. 9 CFR 166.10 - Licensing.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Licensing. 166.10 Section 166.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application....

  17. Licensing of radioactive material (CPR Part 2)

    International Nuclear Information System (INIS)

    This Code of PAEC Regulations (CPR) part 2 sets forth the rules and regulations applicable to all persons in the Philippines governing the licensing of radioactive materials by the Philippine Nuclear Research Institute (PNRI). The following are the parts of the CPR, 1) General provisions, 2) Exceptions, 3) Licenses, 4) Records, reports, inspections and tests, and 5) Enforcement. (ELC)

  18. Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology

    OpenAIRE

    Hill Steven M; Neve Richard M; Bayani Nora; Kuo Wen-Lin; Ziyad Safiyyah; Spellman Paul T; Gray Joe W; Mukherjee Sach

    2012-01-01

    Abstract Background An important question in the analysis of biochemical data is that of identifying subsets of molecular variables that may jointly influence a biological response. Statistical variable selection methods have been widely used for this purpose. In many settings, it may be important to incorporate ancillary biological information concerning the variables of interest. Pathway and network maps are one example of a source of such information. However, although ancillary informatio...

  19. Application of surface plasmons to biological and chemical sensors

    International Nuclear Information System (INIS)

    Surface plasmons (SPs) are a collective normal mode of electrons localized at a metallic surface. It has been used for biological sensors since 1990s. This is because it has the following specific characters: (a) The resonance condition is sensitive to the surrounding dielectric constants (refractive indexes) and (b) Highly enhanced optical-electric-fields are produced adjacent to SPs. A brief introduction is given on the principle of the biological and chemical sensors based on SPs for the readers working in the fields other than SPs, followed by a review on the recent developments of the biological and chemical sensors. (author)

  20. 9th International Conference on Practical Applications of Computational Biology and Bioinformatics

    CERN Document Server

    Rocha, Miguel; Fdez-Riverola, Florentino; Paz, Juan

    2015-01-01

    This proceedings presents recent practical applications of Computational Biology and  Bioinformatics. It contains the proceedings of the 9th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, at June 3rd-5th, 2015. The International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB) is an annual international meeting dedicated to emerging and challenging applied research in Bioinformatics and Computational Biology. Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis o...

  1. Scalable pattern recognition algorithms applications in computational biology and bioinformatics

    CERN Document Server

    Maji, Pradipta

    2014-01-01

    Reviews the development of scalable pattern recognition algorithms for computational biology and bioinformatics Includes numerous examples and experimental results to support the theoretical concepts described Concludes each chapter with directions for future research and a comprehensive bibliography

  2. Thiosemicarbazones: preparation methods, synthetic applications and biological importance

    International Nuclear Information System (INIS)

    Thiosemicarbazones are a class of compounds known by their chemical and biological properties, such as antitumor, antibacterial, antiviral and antiprotozoal activity. Their ability to form chelates with metals has great importance in their biological activities. Their synthesis is very simple, versatile and clean, usually giving high yields. They are largely employed as intermediates, in the synthesis of others compounds. This article is a survey of some of these characteristics showing their great importance to organic and medicinal chemistry. (author)

  3. Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

    OpenAIRE

    Ye-Rang Yun; Jong Eun Won; Eunyi Jeon; Sujin Lee; Wonmo Kang; Hyejin Jo; Jun-Hyeog Jang; Ueon Sang Shin; Hae-Won Kim

    2010-01-01

    Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain opt...

  4. Sparse combinatorial inference with an application in cancer biology

    OpenAIRE

    Mukherjee, Sach; Pelech, Steven; Neve, Richard M.; Kuo, Wen-Lin; Ziyad, Safiyyah; Spellman, Paul T.; Joe W Gray; Speed, Terence P.

    2008-01-01

    Motivation: Combinatorial effects, in which several variables jointly influence an output or response, play an important role in biological systems. In many settings, Boolean functions provide a natural way to describe such influences. However, biochemical data using which we may wish to characterize such influences are usually subject to much variability. Furthermore, in high-throughput biological settings Boolean relationships of interest are very often sparse, in the sense of being embedde...

  5. Computational Systems Biology in Cancer: Modeling Methods and Applications

    OpenAIRE

    Wayne Materi; Wishart, David S.

    2007-01-01

    In recent years it has become clear that carcinogenesis is a complex process, both at the molecular and cellular levels. Understanding the origins, growth and spread of cancer, therefore requires an integrated or system-wide approach. Computational systems biology is an emerging sub-discipline in systems biology that utilizes the wealth of data from genomic, proteomic and metabolomic studies to build computer simulations of intra and intercellular processes. Several useful descriptive and pre...

  6. Application of E-infinity theory to biology

    International Nuclear Information System (INIS)

    Albert Einstein combined continuous space and time into his special relativity, El-Naschie discovered the transfinite discontinuity of space-time in his E-infinity theory where infinity of dimensions was created. We find a partner of both space-time and E-infinity in biology. In our theory, the number of cells in an organism endows an additional dimension in biology, leading to explanation of many complex phenomena

  7. Isothermal Calorimetry for Biological Applications in Food Science and Technology

    OpenAIRE

    Wadsö, Lars; Gomez, Federico

    2009-01-01

    All physical, chemical and biological processes produce heat and isothermal calorimetry is a general measurement technique to study all kinds of processes by the heat they produce. This paper gives several examples of studies of biological processes in the food area using isothermal calorimetry. It is for example shown how different unit operations influence respiration of vegetable tissue, how the kinetics of a fermentation process can be studied, and how spoilage processes can be followed f...

  8. Natural analog studies: Licensing perspective

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.W. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This report describes the licensing perspective of the term {open_quotes}natural analog studies{close_quotes} as used in CFR Part 60. It describes the misunderstandings related to its definition which has become evident during discussions at the U.S Nuclear Regulatory Commission meetings and tries to clarify the appropriate applications of natural analog studies to aspects of repository site characterization.

  9. Technical Challenges in the Application and Licensing of Digital Instrumentation and Control Systems in Nuclear Power Plants

    International Nuclear Information System (INIS)

    With the modernization of existing analogue instrumentation and control (I&C) systems in nuclear power plants through digital I&C technology, and the implementation of digital I&C systems in new plants, the industry is faced with significant challenges. These challenges appear in the form of difficulties in managing the necessarily incremental transition, highly integrated (and interdependent) architectures, the flexible configurability enabled by digital technology, and uncertainty and inconsistency in licensing digital I&C systems and equipment in the different Member States. This publication discusses 17 major issues that utilities, developers, suppliers and regulatory stakeholders need to consider, so that the industry can capture and benefit from shared experience, recent technological developments, and emerging best practices

  10. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  11. NRC licensing requirements: DOD options

    Energy Technology Data Exchange (ETDEWEB)

    Pike, W.J.; O' Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  12. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90Sr or 238Pu; radioisotopic dynamic electric generators with 90Sr or 238Pu; and applications of radioisotopes for luminous sources (lights) with 3H, 85Kr, or 147Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  13. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  14. Biological Membrane Ion Channels Dynamics, Structure, and Applications

    CERN Document Server

    Chung, Shin-Ho; Krishnamurthy, Vikram

    2007-01-01

    Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the area of ion channel investigations

  15. A first course in computing with applications to biology.

    Science.gov (United States)

    Libeskind-Hadas, Ran; Bush, Eliot

    2013-09-01

    We believe that undergraduate biology students must acquire a foundational background in computing including how to formulate a computational problem; develop an algorithmic solution; implement their solution in software and then test, document and use their code to explore biological phenomena. Moreover, by learning these skills in the first year, students acquire a powerful tool set that they can use and build on throughout their studies. To address this need, we have developed a first-year undergraduate course that teaches students the foundations of computational thinking and programming in the context of problems in biology. This article describes the structure and content of the course and summarizes assessment data on both affective and learning outcomes. PMID:23449003

  16. Synthetic Biology and Human Health: Potential Applications for Spaceflight

    Science.gov (United States)

    Karouia, Fathi; Carr, Christopher; Cai, Yizhi; Chen, Y.; Grenon, Marlene; Larios-Sanz, Maia; Jones, Jeffrey A.; Santos, Orlando

    2011-01-01

    Human space travelers experience a unique environment that affects homeostasis and physiologic adaptation. Spaceflight-related changes have been reported in the musculo-skeletal, cardiovascular, neurovestibular, endocrine, and immune systems. The spacecraft environment further subjects the traveler to noise and gravitational forces, as well as airborne chemical, microbiological contaminants, and radiation exposure. As humans prepare for longer duration missions effective countermeasures must be developed, verified, and implemented to ensure mission success. Over the past ten years, synthetic biology has opened new avenues for research and development in areas such as biological control, biomaterials, sustainable energy production, bioremediation, and biomedical therapies. The latter in particular is of great interest to the implementation of long-duration human spaceflight capabilities. This article discusses the effects of spaceflight on humans, and reviews current capabilities and potential needs associated with the health of the astronauts where synthetic biology could play an important role in the pursuit of space exploration.

  17. Application of Computational Systems Biology to Explore Environmental Toxicity Hazards

    DEFF Research Database (Denmark)

    Audouze, Karine Marie Laure; Grandjean, P.

    2011-01-01

    BACKGROUND: Computer-based modeling is part of a new approach to predictive toxicology. OBJECTIVES: We investigated the usefulness of an integrated computational systems biology approach in a case study involving the isomers and metabolites of the pesticide dichlorodiphenyltrichloroethane (DDT) to...... ascertain their possible links to relevant adverse effects. METHODS: We extracted chemical protein association networks for each DDT isomer and its metabolites using Chem Prot, a disease chemical biology database that includes both binding and gene expression data, and we explored protein protein...

  18. Nuclear power stations licensing

    International Nuclear Information System (INIS)

    The judicial aspects of nuclear stations licensing are presented. The licensing systems of the United States, Spain, France and Federal Republic of Germany are focused. The decree n0 60.824 from July 7 sup(th), 1967 and the following legislation which define the systematic and area of competence in nuclear stations licensing are analysed

  19. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  20. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff`s review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission`s regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements.

  1. Standard review plan for the review of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the nuclear power industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  2. Current status of the PBMR licensing project

    International Nuclear Information System (INIS)

    The CNS is currently reviewing the PBMR conceptual design from a licensibility point of view. The PBMR concept is based on a High Temperature Gas Cooled Reactor - pebble bed reactor type. It is anticipated that the PBMR design will rely on inherent safety characteristics to contain fission products within fuel over the full range of design basis events. This feature combined with the high temperature integrity of the fuel and structural graphite, allows the safe use of a high coolant temperature, which allows consideration of the future development of this reactor for non-electrical applications of nuclear heat for industrial use. The CNS licensing approach requires that the licensing and design basis of the plant should respect prevailing international norms and practices and that a quantitative risk assessment should demonstrate compliance with the CNS fundamental safety standards. The first stage of the licensing process is now ongoing; this is a pre-application phase, which will result in a statement on licensibility being issued. Identification of the specific documentation requirements and information needed is required across every step of the licensing process. Top level regulatory requirements have been established for the PBMR. They include the CNS fundamental safety standard and basic licensing criteria, which describes requirements on licensees of nuclear installations regarding risk assessment and compliance with the safety criteria and define classification of licensing basis events. (author)

  3. DNA Synthesis, Assembly and Applications in Synthetic Biology

    OpenAIRE

    Ma, Siying; Tang, Nicholas; Tian, Jingdong

    2012-01-01

    The past couple of years saw exciting new developments in microchip-based gene synthesis technologies. Such technologies hold the potential for significantly increasing the throughput and decreasing the cost of gene synthesis. Together with more efficient enzymatic error correction and genome assembly methods, these new technologies are pushing the field of synthetic biology to a higher level.

  4. Some Applications of Mathematics for the Biology Classroom

    Science.gov (United States)

    Horton, Robert M.; Leonard, William H.

    2013-01-01

    Biology and mathematics are inextricably linked. In this article, we show a few of the many areas in which this linkage might be made explicit. By doing so, teachers can deepen students' understanding and appreciation of both subjects. In this article, we explore some of these areas, providing brief explanations of the mathematics and some of the…

  5. A safety licensable computing architecture

    CERN Document Server

    Halang, WA; Jung, S-K; Scheepstra, JJ

    1993-01-01

    This book describes the design of a low complexity, fault-detecting computer architecture for utilisation in programmable logic controllers (PLCs) for process control purposes. The cyclic operating mode of PLCs and a specification level graphical programming paradigm based on interconnecting application-oriented standard software function modules are architecturally supported. Thus, by design, there is no semantic gap between the specification, programming and machine execution levels enabling the safety licensing of application software by diverse back translation, an extremely simple but rig

  6. IRIS Licensing Status

    Energy Technology Data Exchange (ETDEWEB)

    Kling, Charles L.; Carelli, Mario D. [Westinghouse Electric Company, Windsor (United States)

    2006-04-15

    The International Reactor Innovative and Secure (IRIS) nuclear power plant is well into the pre-application review process with the US NRC and has accomplished its first near term goal of obtaining US NRC feedback on the long term testing program. To date, the IRIS team has submitted to the US NRC a number of documents patterned after the Evaluation Model Development and Assessment Process (EMDAP) outlined in Regulatory Guide 1,203. They have covered a detailed description of IRIS, initial safety analysis results, PIRT development for limiting transients, scaling analysis and a description of the test program. The IRIS Safety-by-Desing{sup TM} intrinsically eliminates and/or significantly reduces the consequences of traditional LWR accidents. In addition, the fewer passive safety systems are similar in principle to those of the US NRC approved AP1000 design. For these reasons, the IRIS testing program only needs to include those features unique to the IRIS design. NRC feedback was that the planned test program appeared to be complete and could generate sufficient information to support a Design Certification (DC) submittal. The US NRC has also stated that a DC application must include complete information regarding the test program. On this basis the IRIS team has initiated an aggressive program to conduct IRIS testing to support a DC submittal by the end of 2008. Subsequent US NRC review should be expeditious because of the AP1000 precedent, allowing IRIS to obtain its Final Design Approval (FDA) in 2012; thereby, maintaining its goal of deployment in the 2015-2017 time frame. The next steps in the pre-application review process will be to provide the US NRC with a road map of the anticipated IRIS licensing process, a review of current licensing requirements showing that IRIS meets or exceeds all current criteria and information to support the long term goal of redefining the Emergency Planning Zone (EPZ)

  7. Applications of membrane computing in systems and synthetic biology

    CERN Document Server

    Gheorghe, Marian; Pérez-Jiménez, Mario

    2014-01-01

    Membrane Computing was introduced as a computational paradigm in Natural Computing. The models introduced, called Membrane (or P) Systems, provide a coherent platform to describe and study living cells as computational systems. Membrane Systems have been investigated for their computational aspects and employed to model problems in other fields, like: Computer Science, Linguistics, Biology, Economy, Computer Graphics, Robotics, etc. Their inherent parallelism, heterogeneity and intrinsic versatility allow them to model a broad range of processes and phenomena, being also an efficient means to solve and analyze problems in a novel way. Membrane Computing has been used to model biological systems, becoming with time a thorough modeling paradigm comparable, in its modeling and predicting capabilities, to more established models in this area. This book is the result of the need to collect, in an organic way, different facets of this paradigm. The chapters of this book, together with the web pages accompanying th...

  8. Application of computational systems biology to explore environmental toxicity hazards

    DEFF Research Database (Denmark)

    Audouze, Karine Marie Laure; Grandjean, Philippe

    2011-01-01

    Background: Computer-based modeling is part of a new approach to predictive toxicology.Objectives: We investigated the usefulness of an integrated computational systems biology approach in a case study involving the isomers and metabolites of the pesticide dichlorodiphenyltrichloroethane (DDT......) to ascertain their possible links to relevant adverse effects.Methods: We extracted chemical-protein association networks for each DDT isomer and its metabolites using ChemProt, a disease chemical biology database that includes both binding and gene expression data, and we explored protein-protein interactions...... using a human interactome network. To identify associated dysfunctions and diseases, we integrated protein-disease annotations into the protein complexes using the Online Mendelian Inheritance in Man database and the Comparative Toxicogenomics Database.Results: We found 175 human proteins linked to p...

  9. Neutron scattering applications in structural biology: now and the future

    Energy Technology Data Exchange (ETDEWEB)

    Trewhella, J. [Los Alamos National Lab., NM (United States)

    1996-05-01

    Neutrons have an important role to play in structural biology. Neutron crystallography, small-angle neutron scattering and inelastic neutron scattering techniques all contribute unique information on biomolecular structures. In particular, solution scattering techniques give critical information on the conformations and dispositions of the components of complex assemblies under a wide variety of relevant conditions. The power of these methods is demonstrated here by studies of protein/DNA complexes, and Ca{sup 2+}-binding proteins complexed with their regulatory targets. In addition, we demonstrate the utility of a new structural approach using neutron resonance scattering. The impact of biological neutron scattering to date has been constrained principally by the available fluxes at neutron sources and the true potential of these approaches will only be realized with the development of new more powerful neutron sources. (author)

  10. Fish gelatin thin film standards for biological application of PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Manuel, Jack E., E-mail: jaelma@gmail.com [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States); Rout, Bibhudutta; Szilasi, Szabolcs Z.; Bohara, Gyanendra [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States); Deaton, James; Luyombya, Henry [Louisiana Accelerator Center, University of Louisiana at Lafayette, Lafayette, LA 70503 (United States); Briski, Karen P. [Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA 71209 (United States); Glass, Gary A. [Ion Beam Modification and Analysis Laboratory, University of North Texas, Denton, TX 76203 (United States)

    2014-08-01

    There exists a critical need to understand the flow and accumulation of metallic ions, both naturally occurring and those introduced to biological systems. In this paper the results of fabricating thin film elemental biological standards containing nearly any combination of trace elements in a protein matrix are presented. Because it is capable of high elemental sensitivity, particle induced X-ray emission spectrometry (PIXE) is an excellent candidate for in situ analysis of biological tissues. Additionally, the utilization of microbeam PIXE allows the determination of elemental concentrations in and around biological cells. However, obtaining elemental reference standards with the same matrix constituents as brain tissue is difficult. An excellent choice for simulating brain-like tissue is Norland® photoengraving glue which is derived from fish skin. Fish glue is water soluble, liquid at room temperature, and resistant to dilute acid. It can also be formed into a thin membrane which dries into a durable, self-supporting film. Elements of interest are introduced to the fish glue in precise volumetric additions of well quantified atomic absorption standard solutions. In this study GeoPIXE analysis package is used to quantify elements intrinsic to the fish glue as well as trace amounts of manganese added to the sample. Elastic (non-Rutherford) backscattered spectroscopy (EBS) and the 1.734 MeV proton-on-carbon {sup 12}C(p,p){sup 12}C resonance is used for a normalization scheme of the PIXE spectra to account for any discrepancies in X-ray production arising from thickness variation of the prepared standards. It is demonstrated that greater additions of the atomic absorption standard cause a viscosity reduction of the liquid fish glue resulting in thinner films but the film thickness can be monitored by using simultaneous PIXE and EBS proton data acquisition.

  11. Applications of Case-Based Reasoning in Molecular Biology

    OpenAIRE

    Jurisica, Igor; Glasgow, Janice

    2004-01-01

    Case-based reasoning (CBR) is a computational reasoning paradigm that involves the storage and retrieval of past experiences to solve novel problems. It is an approach that is particularly relevant in scientific domains, where there is a wealth of data but often a lack of theories or general principles. This article describes several CBR systems that have been developed to carry out planning, analysis, and prediction in the domain of molecular biology.

  12. Application of scanning electrochemical microscopy to biological samples

    OpenAIRE

    Lee, C.(Institute of Physics, Academia Sinica, Taipei, Taiwan); Kwak, J.; Bard, A J

    1990-01-01

    The scanning electrochemical microscope can be used in the feedback mode in two-dimensional scans over biological substrates to obtain topographic information at the micrometer level. In this mode, the effect of distance between a substrate (either conductive or insulating) and a scanning ultramicroelectrode tip on the electrolytic current flowing at the tip is recorded as a function of the tip x-y position. Scans of the upper surface of a grass leaf and the lower surface of a Ligustrum sinen...

  13. Biclustering Methods: Biological Relevance and Application in Gene Expression Analysis

    OpenAIRE

    Ali Oghabian; Sami Kilpinen; Sampsa Hautaniemi; Elena Czeizler

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expressi...

  14. Application of Biological Tissue Grafts for Burns in Zambia

    International Nuclear Information System (INIS)

    The author discusses the advances made in the use of Biological Tissue Grafts for the treatment of burns.The paper outlines research activities and clinical trials done in the use of gamma radiation sterilised Amnion membranes and Pig skin grafts in the zambian Heath Care System for treatment of Burns.Ethical issues of Tissue Banking are also discussed in relation to religious and cultural beliefs and Good Manufacturing Practices

  15. Application of Mitochondrial DNA Polymorphism to Meloidogyne Molecular Population Biology

    OpenAIRE

    Hyman, B. C.; Whipple, L.E.

    1996-01-01

    Recent advances in molecular biology have enabled the genotyping of individual nematodes, facilitating the analysis of genetic variability within and among plant-pathogenic nematode isolates. This review first describes representative examples of how RFLP, RAPD, AFLP, and DNA sequence analysis have been employed to describe populations of several phytonematodes, including the pinewood, burrowing, root-knot, and cyst nematodes. The second portion of this paper evaluates the utility of a size-v...

  16. C-Nucleosides: Synthetic Strategies and Biological Applications

    Czech Academy of Sciences Publication Activity Database

    Štambaský, J.; Hocek, Michal; Kočovský, P.

    2009-01-01

    Roč. 109, č. 12 (2009), s. 6729-6764. ISSN 0009-2665 R&D Projects: GA MŠk LC512; GA AV ČR IAA400550902 Grant ostatní: NIH(US) 1R03TW007372-01 Institutional research plan: CEZ:AV0Z40550506 Keywords : nucleosides * nucleobases * biological activity * extension of genetic alphabet Subject RIV: CC - Organic Chemistry Impact factor: 35.957, year: 2009

  17. Fish gelatin thin film standards for biological application of PIXE

    International Nuclear Information System (INIS)

    There exists a critical need to understand the flow and accumulation of metallic ions, both naturally occurring and those introduced to biological systems. In this paper the results of fabricating thin film elemental biological standards containing nearly any combination of trace elements in a protein matrix are presented. Because it is capable of high elemental sensitivity, particle induced X-ray emission spectrometry (PIXE) is an excellent candidate for in situ analysis of biological tissues. Additionally, the utilization of microbeam PIXE allows the determination of elemental concentrations in and around biological cells. However, obtaining elemental reference standards with the same matrix constituents as brain tissue is difficult. An excellent choice for simulating brain-like tissue is Norland® photoengraving glue which is derived from fish skin. Fish glue is water soluble, liquid at room temperature, and resistant to dilute acid. It can also be formed into a thin membrane which dries into a durable, self-supporting film. Elements of interest are introduced to the fish glue in precise volumetric additions of well quantified atomic absorption standard solutions. In this study GeoPIXE analysis package is used to quantify elements intrinsic to the fish glue as well as trace amounts of manganese added to the sample. Elastic (non-Rutherford) backscattered spectroscopy (EBS) and the 1.734 MeV proton-on-carbon 12C(p,p)12C resonance is used for a normalization scheme of the PIXE spectra to account for any discrepancies in X-ray production arising from thickness variation of the prepared standards. It is demonstrated that greater additions of the atomic absorption standard cause a viscosity reduction of the liquid fish glue resulting in thinner films but the film thickness can be monitored by using simultaneous PIXE and EBS proton data acquisition

  18. Biological membranes at large length scales: Biological applications and computational modeling

    Science.gov (United States)

    Maibaum, Lutz

    2012-10-01

    Biological membranes, such as the plasma membrane surrounding cells, perform an astonishing variety of essential functions: they provide structural support, regulate trafficking, and control endocytosis and fusion events, among others. Some of these capabilities are due to a membrane's elastic properties: at typical length scales of hundreds of nanometers, it can be thought of as a two-dimensional fluid sheet that exhibits significant fluctuations. This mesoscopic picture can be used to model several biological processes, including the formation of cellular protrusions due to interactions between the cytoskeleton and the cell membrane. We show that a membrane can bundle polymerizing actin filaments, thereby enabling the formation of tubular structures that resemble filopodia observed in motile cells. To study this and similar processes that involve the cell membrane over large length scales, we have developed a new computational model that correctly captures the effects of bending rigidity and fluidity. We show that our model exhibits an elastic response to perturbations that is consistent with the Canham-Helfrich description of lipid bilayers, while also providing a computationally efficient way to capture the effects of shape fluctuations.

  19. BioInt: an integrative biological object-oriented application framework and interpreter.

    Science.gov (United States)

    Desai, Sanket; Burra, Prasad

    2015-01-01

    BioInt, a biological programming application framework and interpreter, is an attempt to equip the researchers with seamless integration, efficient extraction and effortless analysis of the data from various biological databases and algorithms. Based on the type of biological data, algorithms and related functionalities, a biology-specific framework was developed which has nine modules. The modules are a compilation of numerous reusable BioADTs. This software ecosystem containing more than 450 biological objects underneath the interpreter makes it flexible, integrative and comprehensive. Similar to Python, BioInt eliminates the compilation and linking steps cutting the time significantly. The researcher can write the scripts using available BioADTs (following C++ syntax) and execute them interactively or use as a command line application. It has features that enable automation, extension of the framework with new/external BioADTs/libraries and deployment of complex work flows. PMID:26561020

  20. Image Processing Technology in the Motor Vehicle License Plate Recognition Technology Application%图像处理技术在机动车车牌自动识别技术中的应用

    Institute of Scientific and Technical Information of China (English)

    宁彬

    2013-01-01

    主要分析了图像处理技术在机动车车牌自动识别技术中的应用.按照车牌定位由彩色图转化到灰度图、车牌区域分割、车牌位置校正等步骤,对车牌字符的识别进行了分析,并对自动识别技术进行了改进.基于图像处理技术设计的机动车辆车牌自动识别系统,在保障交通顺畅运行方面发挥着巨大作用.从实际应用效果看图像处理技术在机动车车牌自动识别技术实际运用中效果良好,具有一定的推广价值.%The application of image processing technology in the motor vehicle license plate automatic identification technology was analyzed. In accordance with the license plate location transformed by the color chart to grayscale, license plate region segmentation, the license plate position correction step on the license plate character recognition, and automatic identification technology improvements. Motor vehicle car brand automatic identification system design based on the image processing technology, play a huge role in the protection of traffic running smoothly. From the effect of practical application of image processing technology in the motor vehicle license plate automatic identification technology to practical use in the good results, the promotional value.

  1. Laser digital photography and its application to biology of pests

    Czech Academy of Sciences Publication Activity Database

    Weyda, František

    Brno : Mendelova zemědělská a lesnická univerzita v Brně, 2009 - (Šafránková, I.; Šefrová, H.). s. 177-177 ISBN 978-80-7375-316-0. [Česká a slovenská konference o ochraně rostlin /18./. 02.09.2009-04.09.2009, Brno] R&D Projects: GA MŠk 2B06005 Institutional research plan: CEZ:AV0Z50070508 Keywords : laser digital photography Subject RIV: EA - Cell Biology

  2. Dynamic light scattering with applications to chemistry, biology, and physics

    CERN Document Server

    Berne, Bruce J

    2000-01-01

    Lasers play an increasingly important role in a variety of detection techniques, making inelastic light scattering a tool of growing value in the investigation of dynamic and structural problems in chemistry, biology, and physics. Until the initial publication of this work, however, no monograph treated the principles behind current developments in the field.This volume presents a comprehensive introduction to the principles underlying laser light scattering, focusing on the time dependence of fluctuations in fluid systems; it also serves as an introduction to the theory of time correlation f

  3. Photonic applications based on biological/inorganic nano hybrids

    Science.gov (United States)

    Zhang, Xin; Wu, Pengfei; Yelleswarapu, Chandra

    2016-02-01

    Biological Retinal is an effective and efficient photochromic compounds and one of the best candidates for photon conversion, transmission and storage, from the view of bionics and natural selection. We observed large optical nonlinearity by using new fabricated films of photoactive Retinol hybrid materials. Based on reversible photoinduced anisotropy and transient optical characteristics, the Retinol hybrids can be used to design novel photonic devices, such as holographic elements, all-optical switch and spatial light modulator. Also, the study is important for further understanding the photochemical mechanism of vision process.

  4. Blueprints for green biotech: development and application of standards for plant synthetic biology.

    Science.gov (United States)

    Patron, Nicola J

    2016-06-15

    Synthetic biology aims to apply engineering principles to the design and modification of biological systems and to the construction of biological parts and devices. The ability to programme cells by providing new instructions written in DNA is a foundational technology of the field. Large-scale de novo DNA synthesis has accelerated synthetic biology by offering custom-made molecules at ever decreasing costs. However, for large fragments and for experiments in which libraries of DNA sequences are assembled in different combinations, assembly in the laboratory is still desirable. Biological assembly standards allow DNA parts, even those from multiple laboratories and experiments, to be assembled together using the same reagents and protocols. The adoption of such standards for plant synthetic biology has been cohesive for the plant science community, facilitating the application of genome editing technologies to plant systems and streamlining progress in large-scale, multi-laboratory bioengineering projects. PMID:27284031

  5. Assessment report: Application from OKG AB for a license according to the Act on Nuclear Activities concerning a shallow land burial/landfill for low-level nuclear waste in Simpevarp in the Oskarshamn municipality

    International Nuclear Information System (INIS)

    OKG AB has to SSI submitted an application for a license according to the Act on Nuclear Activities (1984:3) concerning a shallow land burial/landfill for low-level nuclear waste in Simpevarp in the Oskarshamn municipality. The application for a license covers permission to build, possess and operate a shallow land burial/landfill for low-level nuclear waste. Attached to the application is an environmental impact statement. An application for a license according to the Environmental Act (1998:808) has been submitted to the Environmental Court in Vaexjoe. SSI has circulated the application for consideration to the Swedish Nuclear Power Inspectorate, the Swedish Environmental Protection Agency, the County Government Board of Kalmar and the Oskarshamn municipality. SSI has informed the European Commission about the application in accordance with the EURATOM Treaty, article 37. This assessment report constitutes the base for the decision by SSI 2000-09-18 for approval and radiation protection conditions. In the report, earlier permissions for shallow land burials/landfills at the Swedish nuclear installations are described. This report shows the development of the legal system during the last years, the premises for the assessment of the application, and SSI's review of OKG's plans, consequence analysis and environmental impact statement

  6. Stochastic narrow escape in molecular and cellular biology analysis and applications

    CERN Document Server

    Holcman, David

    2015-01-01

    This book covers recent developments in the non-standard asymptotics of the mathematical narrow escape problem in stochastic theory, as well as applications of the narrow escape problem in cell biology. The first part of the book concentrates on mathematical methods, including advanced asymptotic methods in partial equations, and is aimed primarily at applied mathematicians and theoretical physicists who are interested in biological applications. The second part of the book is intended for computational biologists, theoretical chemists, biochemists, biophysicists, and physiologists. It includes a summary of output formulas from the mathematical portion of the book and concentrates on their applications in modeling specific problems in theoretical molecular and cellular biology. Critical biological processes, such as synaptic plasticity and transmission, activation of genes by transcription factors, or double-strained DNA break repair, are controlled by diffusion in structures that have both large and small sp...

  7. Characterizing seamless ligation cloning extract for synthetic biological applications.

    Science.gov (United States)

    Messerschmidt, Katrin; Hochrein, Lena; Dehm, Daniel; Schulz, Karina; Mueller-Roeber, Bernd

    2016-09-15

    Synthetic biology aims at designing and engineering organisms. The engineering process typically requires the establishment of suitable DNA constructs generated through fusion of multiple protein coding and regulatory sequences. Conventional cloning techniques, including those involving restriction enzymes and ligases, are often of limited scope, in particular when many DNA fragments must be joined or scar-free fusions are mandatory. Overlap-based-cloning methods have the potential to overcome such limitations. One such method uses seamless ligation cloning extract (SLiCE) prepared from Escherichia coli cells for straightforward and efficient in vitro fusion of DNA fragments. Here, we systematically characterized extracts prepared from the unmodified E. coli strain DH10B for SLiCE-mediated cloning and determined DNA sequence-associated parameters that affect cloning efficiency. Our data revealed the virtual absence of length restrictions for vector backbone (up to 13.5 kbp) and insert (90 bp to 1.6 kbp). Furthermore, differences in GC content in homology regions are easily tolerated and the deletion of unwanted vector sequences concomitant with targeted fragment insertion is straightforward. Thus, SLiCE represents a highly versatile DNA fusion method suitable for cloning projects in virtually all molecular and synthetic biology projects. PMID:27311554

  8. Tailor-made nanomaterials for biological and medical applications

    Science.gov (United States)

    Tréguer-Delapierre, M.; Rocco, F.; Cardinal, T.; Mornet, S.; Vasseur, S.; Duguet, E.

    2006-02-01

    The possibilities of designing and mastering the new physical and chemical properties of nano-structured materials have been at the center of the large interest they have received in the academic and industrial domains. Confinement effects and the enhanced role of the interface are key parameters. Designing composite materials with controlled nanometric interfacing of different materials is offering new possibilities for developing new structures. Proper design allows to create new properties to meet biological requirements. The purpose of this work is to illustrate the synthesis of various types of nanocrystalline materials that can be used to tackle biological problems inside or outside of living specimens, such as targeted drug delivery, ultra-sensitive disease detection and cell labelling. Two main classes of nanomaterials uses will be discussed. The nanocrystalline materials developed are highly dispersable in water and coated providing biocompatibility. They are elaborated either by precipitation or radiolysis. First, magnetic particles, often called (U)SPIO for (Ultrasmall) SuperParamagnetic Iron Oxide, used as contrast agent for Magnetic Resonance Imaging (MRI) will be presented. Their use for magnetic hyperthermia is now envisaged for cancer treatment. Second, a new generation of inorganic luminophors based on metal colloidal particles will be shown. The coupling of plasmon in nearby particles (semiconductor or metal clusters) is used to enhance their oscillator strength and to target the incident energy. The resulting composite nano-objects can be used for making the smallest possible labels with large oscillator strengths. Those objects will greatly expand the accessibility of single molecule methods.

  9. 75 FR 39667 - Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent Application

    Science.gov (United States)

    2010-07-12

    ... for preparing multivalent vaccines, recombinant DNA expression ] products and more particularly to..., Dr. Paul Mele, Office of Research and Technology Applications (ORTA), (301) 619- 6664, both...

  10. Quantum Information Biology: From Information Interpretation of Quantum Mechanics to Applications in Molecular Biology and Cognitive Psychology

    Science.gov (United States)

    Asano, Masanari; Basieva, Irina; Khrennikov, Andrei; Ohya, Masanori; Tanaka, Yoshiharu; Yamato, Ichiro

    2015-10-01

    We discuss foundational issues of quantum information biology (QIB)—one of the most successful applications of the quantum formalism outside of physics. QIB provides a multi-scale model of information processing in bio-systems: from proteins and cells to cognitive and social systems. This theory has to be sharply distinguished from "traditional quantum biophysics". The latter is about quantum bio-physical processes, e.g., in cells or brains. QIB models the dynamics of information states of bio-systems. We argue that the information interpretation of quantum mechanics (its various forms were elaborated by Zeilinger and Brukner, Fuchs and Mermin, and D' Ariano) is the most natural interpretation of QIB. Biologically QIB is based on two principles: (a) adaptivity; (b) openness (bio-systems are fundamentally open). These principles are mathematically represented in the framework of a novel formalism— quantum adaptive dynamics which, in particular, contains the standard theory of open quantum systems.

  11. 10 CFR 50.50 - Issuance of licenses and construction permits.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Issuance of licenses and construction permits. 50.50... FACILITIES Issuance, Limitations, and Conditions of Licenses and Construction Permits § 50.50 Issuance of licenses and construction permits. Upon determination that an application for a license meets the...

  12. Rethinking biology instruction: The application of DNR-based instruction to the learning and teaching of biology

    Science.gov (United States)

    Maskiewicz, April Lee

    Educational studies report that secondary and college level students have developed only limited understandings of the most basic biological processes and their interrelationships from typical classroom experiences. Furthermore, students have developed undesirable reasoning schemes and beliefs that directly affect how they make sense of and account for biological phenomena. For these reasons, there exists a need to rethink instructional practices in biology. This dissertation discusses how the principles of Harel's (1998, 2001) DNR-based instruction in mathematics could be applied to the teaching and learning of biology. DNR is an acronym for the three foundational principles of the system: Duality, Necessity, and Repeated-reasoning. This study examines the application of these three principles to ecology instruction. Through clinical and teaching interviews, I developed models of students' existing ways of understanding in ecology and inferred their ways of thinking. From these models a hypothetical learning trajectory was developed for 16 college level freshmen enrolled in a 10-week ecology teaching experiment. Through cyclical, interpretive analysis I documented and analyzed the evolution of the participants' progress. The results provide empirical evidence to support the claim that the DNR principles are applicable to ecology instruction. With respect to the Duality Principle, helping students develop specific ways of understanding led to the development of model-based reasoning---a way of thinking and the cognitive objective guiding instruction. Through carefully structured problem solving tasks, the students developed a biological understanding of the relationship between matter cycling, energy flow, and cellular processes such as photosynthesis and respiration, and used this understanding to account for observable phenomena in nature. In the case of intellectual necessity, the results illuminate how problem situations can be developed for biology learners

  13. 77 FR 37035 - Goose River Hydro, Inc.; Independence Hydro, LLC; Notice of Application for Transfer of License...

    Science.gov (United States)

    2012-06-20

    ... Energy Regulatory Commission Goose River Hydro, Inc.; Independence Hydro, LLC; Notice of Application for..., Inc. (transferor) and Independence Hydro, LLC (transferee) filed an application for the transfer of..., Independence Hydro, LLC, 220 Maine Mall Road, South Portland, ME 01406, (207) 274-0001. FERC Contact:...

  14. 75 FR 6193 - Union Electric Company dba Ameren/UE; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2010-02-08

    ... Energy Regulatory Commission Union Electric Company dba Ameren/UE; Notice of Application for Amendment of... Filed: November 6, 2009. Supplemented on January 13, 2010. d. Applicant: Union Electric Company dba... manage and maintain the lease area for public access, and would rehabilitate an existing building for...

  15. 75 FR 74704 - South Carolina Electric and Gas Company; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2010-12-01

    .... Additionally, the Applicant would construct an offsite water treatment facility that would withdraw, on average... Nuclear Station. To facilitate this, the Applicant would construct a raw water intake facility that would withdraw approximately 2.2 million gallons of water per hour from Monticello reservoir, as well as a...

  16. 77 FR 27759 - City of Crystal Falls, MI; Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2012-05-11

    ... Energy Regulatory Commission City of Crystal Falls, MI; Notice of Application for Temporary Variance of.... Applicant: City of Crystal Falls, MI. e. Name of Project: Crystal Falls Project. f. Location: The project is located on the Paint River in the City of Crystal Falls, Michigan. g. Filed Pursuant to: Federal Power...

  17. 78 FR 21923 - City of Crystal Falls, MI; Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-04-12

    ... Energy Regulatory Commission City of Crystal Falls, MI; Notice of Application for Temporary Variance of.... Applicant: City of Crystal Falls, MI. e. Name of Project: Crystal Falls Project. f. Location: The project is located on the Paint River in the City of Crystal Falls, Iron County, Michigan. g. Filed Pursuant...

  18. Application of super-resolution optical microscopy in biology

    International Nuclear Information System (INIS)

    Background: A noninvasive, real-time far-field optical microscopy is needed to study the dynamic function inside cells and proteins. However, the resolution limit of traditional optical microscope is about 200 nm due to the diffraction limit of light. So, it's hard to directly observe the subcellular structures. Over the past several years of microscopy development, the diffraction limit of fluorescence microscopy has been overcome and its resolution limit is about tens of nanometers. Methods: To overcome the diffraction limit of light, many super-resolution fluoresce microscopes, including stimulated emission of depletion microscopy (STED), photoactivation localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM), have been developed. Conclusions: These methods have been applied in cell biology, microbiology and neurobiology, and the technology of super-resolution provides a new insight into the life science. (authors)

  19. Application of scanning electrochemical microscopy to biological samples.

    Science.gov (United States)

    Lee, C; Kwak, J; Bard, A J

    1990-03-01

    The scanning electrochemical microscope can be used in the feedback mode in two-dimensional scans over biological substrates to obtain topographic information at the micrometer level. In this mode, the effect of distance between a substrate (either conductive or insulating) and a scanning ultramicroelectrode tip on the electrolytic current flowing at the tip is recorded as a function of the tip x-y position. Scans of the upper surface of a grass leaf and the lower surface of a Ligustrum sinensis leaf (which show open stomata structures) immersed in aqueous solution are shown. Scans of the upper surface of an elodea leaf in the dark and under irradiation, where the tip reaction is the reduction of oxygen produced by photosynthesis, demonstrate the possibility of obtaining information about the distribution of reaction sites on the substrate surface. PMID:2308933

  20. New developments in optical microscopy for biological applications

    International Nuclear Information System (INIS)

    In the past ten years a quiet revolution has been taking place in optical microscopy. So quiet indeed that if one has not been working in life sciences research one may have seen little or no evidence of it. Yet what has been going on is an excellent example of how developments in physical instrumentation drive research and research in turn drives further developments in instrumentation. In this paper I will briefly review these developments in optical microscopy and, in particular, show how processes originally proposed 65 years ago as esoteric theoretical solutions to Dirac's equation are now used in practice for some of the most adventurous biological microscopy yet attempted. Copyright (1998) CSIRO Australia

  1. Testing of Synthetic Biological Membranes for Forward Osmosis Applications

    Science.gov (United States)

    Parodi, Jurek; Mangado, Jaione Romero; Stefanson, Ofir; Flynn, Michael; Mancinelli, Rocco; Kawashima, Brian; Trieu, Serena; Brozell, Adrian; Rosenberg, Kevan

    2016-01-01

    Commercially available forward osmosis membranes have been extensively tested for human space flight wastewater treatment. Despite the improvements achieved in the last decades, there is still a challenge to produce reliable membranes with anti-fouling properties, chemical resistance, and high flux and selectivity. Synthetic biological membranes that mimic the ones present in nature, which underwent millions of years of evolution, represent a potential solution for further development and progress in membrane technology. Biomimetic forward osmosis membranes based on a polymeric support filter and coated with surfactant multilayers have been engineered to investigate how different manufacturing processes impact the performance and structure of the membrane. However, initial results of the first generation prototype membranes tests reveal a high scatter in the data, due to the current testing apparatus set up. The testing apparatus has been upgraded to improve data collection, reduce errors, and to allow higher control of the testing process.

  2. 1,2,4-oxadiazole nucleus with versatile biological applications

    Directory of Open Access Journals (Sweden)

    Mohammad Arshad

    2014-07-01

    Full Text Available Azoles are the five-membered heterocyclic compounds with two or three nitrogen atoms, constitute a large group of organic substances and have been long targeted for their use as therapeutic agents. 1,2,4-oxadiazoles is a member of azole family containing two nitrogen atoms, two carbon and one oxygen atom in the ring.1,2,4- oxadiazoles have been found to possess variety of biological activities such as human tryptase inhibitory activity, antitrypanosomal activity, β-amyloid imaging agents in Alzheimer’s disease, genotoxic activity, peptide inhibitory activity, antihyperglycemic activity, potential combretastatin A-4 (CA-4 analogs and oxadiazole mannich bases show antimyco-bacterial activity. Here in this review article we have reported the recent development in the pharmacological activity of some newly synthesized 1,2,4-oxadiazole derivatives.

  3. Biclustering methods: biological relevance and application in gene expression analysis.

    Science.gov (United States)

    Oghabian, Ali; Kilpinen, Sami; Hautaniemi, Sampsa; Czeizler, Elena

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes). An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical) methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1) we examine how well the considered (bi)clustering methods differentiate various sample types; (2) we evaluate how well the groups of genes discovered by the (bi)clustering methods are annotated with similar Gene Ontology categories; (3) we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4) we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples. PMID:24651574

  4. Biclustering methods: biological relevance and application in gene expression analysis.

    Directory of Open Access Journals (Sweden)

    Ali Oghabian

    Full Text Available DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering methods where genes (or respectively samples are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes. An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1 we examine how well the considered (biclustering methods differentiate various sample types; (2 we evaluate how well the groups of genes discovered by the (biclustering methods are annotated with similar Gene Ontology categories; (3 we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4 we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples.

  5. Selective Chemical-Lithographic Reaction Techniques Using Radiation Technology for Biological Application

    International Nuclear Information System (INIS)

    This report, titled 'selective Chemical-Lithographic Reaction Techniques Using Radiation Technology for Biological Application' contains a research summary, 1) development of selective reaction technology using irradiation of electron beams, 2) preparation of functional surfaces using selective radiation technology on carbon-based nanomaterials, and 3) development of bio-applicable biochips using combinatorial surface modification

  6. Applications of Magnetic Micro- and Nanoparticles in Biology and Medicine

    Science.gov (United States)

    Dobson, J.

    2005-12-01

    Magnetic nanoparticles were first proposed for biomedical applications in the 1970s - primarily as targeted drug delivery vehicles and MRI contrast agents. Since that time, such particles have found application in a variety of biomedical techniques. In addition to drug delivery, magnetic nanoparticles are now used routinely as MRI contrast agents as well as for magneto-immunoassay and cell sorting. More recently, magnetic micro- and nanoparticles have been used to investigate and manipulate cellular processes both in vitro and in vivo. In addition, biogenic magnetic nanoparticles are also produced in the human body. The iron storage protein, ferritin, consists of a superparamagnetic ferrihydrite core and biogenic magnetite (a ferrimagnet) has also been found in the brain and other organs. Though the role of ferritin and several other magnetic iron oxides in the body is well understood, the origin and role of biogenic magnetite is only now coming to light - and this may have profound implications for our understanding of neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases. This talk will review applications related to magnetic particle-mediated activation of cellular processes for tissue engineering applications and novel methods of magnetofection which have the potential to provide enhanced transfection for non-viral therapeutic gene delivery. It will also briefly highlight new techniques recently developed for the mapping and characterization of magnetic iron compounds related to neurodegenerative diseases and how rock magnetic techniques have been adapted to study magnetic iron compounds in the brain and other organs.

  7. Promising Tools for Biological Applications: Nanoparticles and Polyelectrolyte Polymer Capsules

    OpenAIRE

    Munoz, Almudena

    2008-01-01

    In this work, we address two different structures whose sizes are in the nanoscopic and microscopic range, namely nanoparticles and polyelectrolyte polymer capsules respectively. Among a wide variety of their promising applications, some are discussed. Synthesis, characterization and surface modification of semiconductor CdSe/ZnS and metallic Au nanoparticles are presented. Au nanoparticles were synthesized directly in organic sol...

  8. Hanau licenses voided by German state court

    International Nuclear Information System (INIS)

    On July 21, the Higher Administrative Court in the German state of Hesse declared illegal three of the first four partial construction licenses for the plutonium section of the Siemens fuel fabrication complex at Hanau. The licenses were issued in the late 1980s by the former Christian Democrat administration of Hesse, but final licensing of the plant - now 90 percent complete - has been held up by the Social Democrat/Green Party coalition government that is now in power. The court ruling came as a result of four cases, and a so-called urgent application, initiated by antinuclear groups in the area

  9. Trends in nuclear licensing

    International Nuclear Information System (INIS)

    The development of nuclear safety and licensing is briefly reviewed in four stages namely: The Formative Period (1946-1959), The Expansive Period (1960-1969), The Mature Period (1970-1979) and the Apprehensive Period (1980-1989). Particular safety issues in the respective periods are highlighted to indicate the changing emphasis of nuclear licensing over the past thirty years or so. Against this background, nuclear licensing. (author)

  10. Licensing, supervision, retrofitting

    International Nuclear Information System (INIS)

    The lecture deals in detail with questions on the systematization and coordination of the elements the Atomic Energy Act defines as relevant to licensing; discretion to deny a licence for safety reasons - other licensing reservations under environmental law - protection of third parties - provisions for waste disposal and compliance with international obligations - protective aim of the law; questions on a concentrating effect in licensing and other administrative decisions; introduction of a plan approval procedure or site assessment and procedure; staged licensing procedure, dynamization of provisions against damage; subsequent obligations; introduction of periodical safety checks; abolition of the indemnification obligation pursuant to Paragraph 18 Section 3 of the Atomic Energy Act. (HSCH)

  11. 75 FR 32418 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-06-08

    ... publication of this announcement. ADDRESSES: United States Army Engineer Research and Development Center, ATTN... can be used in place of synthetic, petroleum-based polymers for soil amendment applications to...

  12. 75 FR 54115 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-09-03

    ... of this announcement. ADDRESSES: United States Army Engineer Research and Development ] Center, Attn... can be used in place of synthetic, petroleum-based polymers for soil amendment applications to...

  13. 75 FR 19956 - Miller and Miller, Waterpower LLC; Notice of Application for Transfer of License and Soliciting...

    Science.gov (United States)

    2010-04-16

    ... Worthville Dam Project No. 3156, located on the Deep River in Randolph County, North Carolina. Applicants... filed electronically via the Internet. See 18 CFR 385.2001(a)(1)(iii)(2008) and the instructions on...

  14. 75 FR 54116 - Notice of Intent To Grant Partially Exclusive License of the United States Patent Application No...

    Science.gov (United States)

    2010-09-03

    ... bioremediation, dust and run-off control, fly ash removal, emissions particulate removal, metal and inorganic... polymers for soil amendment applications to achieve increased soil strength, reduced air transport,...

  15. Applications of Discrete Molecular Dynamics in biology and medicine.

    Science.gov (United States)

    Proctor, Elizabeth A; Dokholyan, Nikolay V

    2016-04-01

    Discrete Molecular Dynamics (DMD) is a physics-based simulation method using discrete energetic potentials rather than traditional continuous potentials, allowing microsecond time scale simulations of biomolecular systems to be performed on personal computers rather than supercomputers or specialized hardware. With the ongoing explosion in processing power even in personal computers, applications of DMD have similarly multiplied. In the past two years, researchers have used DMD to model structures of disease-implicated protein folding intermediates, study assembly of protein complexes, predict protein-protein binding conformations, engineer rescue mutations in disease-causative protein mutants, design a protein conformational switch to control cell signaling, and describe the behavior of polymeric dispersants for environmental cleanup of oil spills, among other innovative applications. PMID:26638022

  16. The application of statistical physics to evolutionary biology

    OpenAIRE

    Sella, Guy; Hirsh, Aaron E

    2005-01-01

    A number of fundamental mathematical models of the evolutionary process exhibit dynamics that can be difficult to understand analytically. Here we show that a precise mathematical analogy can be drawn between certain evolutionary and thermodynamic systems, allowing application of the powerful machinery of statistical physics to analysis of a family of evolutionary models. Analytical results that follow directly from this approach include the steady-state distribution of fixed genotypes and th...

  17. Criterion of positivity for semilinear problems with applications in biology

    OpenAIRE

    Duprez, Michel; Perasso, Antoine

    2016-01-01

    The goal of this article is to provide an useful criterion of positivity and well-posedness for a wide range of infinite dimensional semilinear abstract Cauchy problems. This criterion is based on some weak assumptions on the non-linear part of the semilinear problem and on the existence of a strongly continuous semigroup generated by the differential operator. To illustrate a large variety of applications, we exhibit the feasibility of this criterion through three examples in mathematical bi...

  18. DIAMAGNETIC LEVITATION ABOVE MICROMAGNETS: APPLICATIONS TO DIGITAL MICROFLUIDICS AND BIOLOGY

    OpenAIRE

    Kauffmann, Paul

    2009-01-01

    Diamagnetic levitation is one of the rare way to compensate action of gravity. This kind of repulsion is negligible at our scale. However, at microscale, this effect becomes significant and can achieve levitation of diamagnetic objects. Through the development of micromagnets, analytical and numerical models, and experiments, applications of diamagnetic levitation of microdroplets and trapping of cells in paramagnetic media is explored. It is shown that diamagnetic levitation allows quantifyi...

  19. Infrared spectroscopic imaging microscopy: Applications to biological systems

    International Nuclear Information System (INIS)

    The coupling of imaging modalities with spectroscopic techniques adds additional dimensions to sample analysis in both the spectroscopic and spatial domains. The particular ability of infrared (IR) imaging to explore the spatial distribution of chemically distinct species on length scales ranging from microns to kilometers demonstrates the versatility and diversity of spectroscopic imaging. In this paper, we focus on the further development of our Fourier-transform (FT) based mid-IR spectroscopic imaging technique which combines the analytical capabilities of mid-IR spectroscopy with the morphological information obtained from optical imaging. The seamless combination of spectroscopy for molecular analysis with the power of visualization represents the future of infrared microscopy. Our spectroscopic imaging instrument integrates several infrared focal-plane arrays with a Michelson step-scan interferometer, generating high-fidelity and high spectral resolution mid-infrared spectroscopic images. The instrumentation produces multidimensional, chemically specific images, while simultaneously obtaining high resolution spectra for each detector pixel. The spatial resolution of the images approaches the diffraction limit for mid-infrared wavelengths, while the spectral resolution is determined by the interferometer, and can be 4 cm-1 or higher. Data derived from a variety of materials, particularly biological samples, illustrate the capabilities of the technique for readily visualizing chemical complexity and for providing statistical data on sample heterogeneity

  20. Cystitis: From Urothelial Cell Biology to Clinical Applications

    Directory of Open Access Journals (Sweden)

    Gilho Lee

    2014-01-01

    Full Text Available Cystitis is a urinary bladder disease with many causes and symptoms. The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden throughout the world and in many cases treatments are ineffective, the mechanisms of its origin and development as well as measures for effective treatment are still poorly understood. However, many studies have demonstrated that urothelial dysfunction plays a crucial role. In the present review we first discuss fundamental issues of urothelial cell biology, which is the core for comprehension of cystitis. Then we focus on many forms of cystitis, its current treatments, and advances in its research. Additionally we review haemorrhagic cystitis with one of the leading causative agents being chemotherapeutic drug cyclophosphamide and summarise its management strategies. At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches.

  1. Review and application of group theory to molecular systems biology.

    Science.gov (United States)

    Rietman, Edward A; Karp, Robert L; Tuszynski, Jack A

    2011-01-01

    In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to molecular systems biology. Throughout this paper we briefly describe possible open problems. In connection with the genetic code we propose that it may be possible to use perturbation theory to explore the adjacent possibilities in the 64-dimensional space-time manifold of the evolving genome. With regards to algebraic graph theory, there are several minor open problems we discuss. In relation to network dynamics and groupoid formalism we suggest that the network graph might not be the main focus for understanding the phenotype but rather the phase space of the network dynamics. We show a simple case of a C6 network and its phase space network. We envision that the molecular network of a cell is actually a complex network of hypercycles and feedback circuits that could be better represented in a higher-dimensional space. We conjecture that targeting nodes in the molecular network that have key roles in the phase space, as revealed by analysis of the automorphism decomposition, might be a better way to drug discovery and treatment of cancer. PMID:21696623

  2. Review and application of group theory to molecular systems biology

    Directory of Open Access Journals (Sweden)

    Rietman Edward A

    2011-06-01

    Full Text Available Abstract In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to molecular systems biology. Throughout this paper we briefly describe possible open problems. In connection with the genetic code we propose that it may be possible to use perturbation theory to explore the adjacent possibilities in the 64-dimensional space-time manifold of the evolving genome. With regards to algebraic graph theory, there are several minor open problems we discuss. In relation to network dynamics and groupoid formalism we suggest that the network graph might not be the main focus for understanding the phenotype but rather the phase space of the network dynamics. We show a simple case of a C6 network and its phase space network. We envision that the molecular network of a cell is actually a complex network of hypercycles and feedback circuits that could be better represented in a higher-dimensional space. We conjecture that targeting nodes in the molecular network that have key roles in the phase space, as revealed by analysis of the automorphism decomposition, might be a better way to drug discovery and treatment of cancer.

  3. Licensing of away-from-reactor (AFR) installations

    International Nuclear Information System (INIS)

    Storage of spent fuel at Away-From-Reactor (AFR) installations will allow reactors to continue to operate until reprocessing or other fuel disposal means are available. AFR installations must be licensed by the Nuclear Regulatory Commission (NRC). Although wide experience in licensing reactors exists, the licensing of an AFR installation is a relatively new activity. Only one has been licensed to date. This paper delineates the requirements for licensing an AFR installation and projects a licensing schedule. Because the NRC is developing specific AFR requirements, this schedule is based primarily on draft NRC documents. The major documents needed for an AFR license application are similar to those for a reactor. They include: a Safety Analysis Report (SAR), and Environmental Report (ER), safeguards and security plans, decommissioning plans, proposed technical specifications, and others. However, the licensing effort has one major difference in that for AFR installations it will be a one-step effort, with follow-up, rather than the two-step process used for reactors. The projected licensing schedule shows that the elapsed time between filing an application and issuance of a license will be about 32 months, assuming intervention. The legal procedural steps will determine the time schedule and will override considerations of technical complexity. A license could be issued in about 14 months in the absence of intervention

  4. 6th International Conference on Practical Applications of Computational Biology & Bioinformatics

    CERN Document Server

    Luscombe, Nicholas; Fdez-Riverola, Florentino; Rodríguez, Juan; Practical Applications of Computational Biology & Bioinformatics

    2012-01-01

    The growth in the Bioinformatics and Computational Biology fields over the last few years has been remarkable.. The analysis of the datasets of Next Generation Sequencing needs new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Also Systems Biology has also been emerging as an alternative to the reductionist view that dominated biological research in the last decades. This book presents the results of the  6th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, 28-30th March, 2012 which brought together interdisciplinary scientists that have a strong background in the biological and computational sciences.

  5. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Borodina, Irina; Li, Mingji

    2015-01-01

    biology has the potential to bring down this cost by improving our ability to predictably engineer biological systems. This review highlights synthetic biology applications for design, assembly, and optimization of non-native biochemical pathways in baker's yeast Saccharomyces cerevisiae. We describe...... computational tools for the prediction of biochemical pathways, molecular biology methods for assembly of DNA parts into pathways, and for introducing the pathways into the host, and finally approaches for optimizing performance of the introduced pathways.......Synthetic biology and metabolic engineering enable generation of novel cell factories that efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating the basis for biosustainable economy independent on fossil resources. While over a hundred proof...

  6. Phosphoproteomics technologies and applications in plant biology research

    Directory of Open Access Journals (Sweden)

    Jinna eLi

    2015-06-01

    Full Text Available Protein phosphorylation has long been recognized as an essential mechanism to regulate many important processes of plant life. However, studies on phosphorylation mediated signaling events in plants are challenged with low stoichiometry and dynamic nature of phosphorylated proteins. Significant advances in mass spectrometry based phosphoproteomics have taken place in recent decade, including phosphoprotein/phosphopeptide enrichment, detection and quantification and phosphorylation site localization. This review describes a variety of separation and enrichment methods for phosphoproteins and phosphopeptides, the applications of technological innovations in plant phosphoproteomics, and highlights significant achievement of phosphoproteomics in the areas of plant signal transduction, growth and development.

  7. Biological Immune System Applications on Mobile Robot for Disabled People

    Directory of Open Access Journals (Sweden)

    Songmin Jia

    2014-01-01

    Full Text Available To improve the service quality of service robots for the disabled, immune system is applied on robot for its advantages such as diversity, dynamic, parallel management, self-organization, and self-adaptation. According to the immune system theory, local environment condition sensed by robot is considered an antigen while robot is regarded as B-cell and possible node as antibody, respectively. Antibody-antigen affinity is employed to choose the optimal possible node to ensure the service robot can pass through the optimal path. The paper details the immune system applications on service robot and gives experimental results.

  8. Laser-based printing and patterning for biological applications

    OpenAIRE

    Sones, C. L.; Katis, I.N.; He, P.; Mills, B.; A. Mosayyebi; Butement, J.; Feinäugle, M.; Eason, R. W.

    2014-01-01

    We present the use of pulsed lasers as patterning and printing tools for the end applications of micro-contact printing and paper-based fluidics. A fs-laser was used with a digital multi-mirror device (DMD) to structure a mould via ablation or photo-polymerisation. The patterns in this mould were then cast into polydimethlysiloxane (PDMS)-mould which was used for micro-contact printing. With the end-goal of producing a microfluidic diagnostic sensor on paper, a ns-laser was used for laser-ind...

  9. On chaotic graphs and applications in physics and biology

    International Nuclear Information System (INIS)

    El Naschie's ε ∞ theory in Quantum space time is given and discussed geometrically and topologically as a category of fuzzy spaces, these fuzzy categories in which lines are fuzzy fractal lines. In this paper, we represent the chaotic graphs as many fuzzy fractal lines up to ∞. We will describe them by chaotic matrices. Many fuzzy systems (chaotic systems) are. This article introduces some operations on the chaotic graphs such as the union and the intersection; also both of the chaotic incidence matrices and the chaotic adjacency matrices representing the chaotic graphs induced from these operations will be studied. Theorems governing these studies are obtained. Some applications on chaotic graphs are given

  10. Human mesenchymal stem cells: from basic biology to clinical applications

    DEFF Research Database (Denmark)

    Abdallah, B M; Kassem, M

    2008-01-01

    Mesenchymal stem cells (MSC) are a group of clonogenic cells present among the bone marrow stroma and capable of multilineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. Due to their ease of isolation and their differentiation potential, MSC are being...... introduced into clinical medicine in variety of applications and through different ways of administration. Here, we discuss approaches for isolation, characterization and directing differentiation of human mesenchymal stem cells (hMSC). An update of the current clinical use of the cells is also provided....

  11. Applications of aerospace technology in biology and medicine

    Science.gov (United States)

    Rouse, D. J.

    1983-01-01

    Utilization of NASA technology and its application to medicine is discussed. The introduction of new or improved commercially available medical products and incorporation of aerospace technology is outlined. A biopolar donor-recipient model of medical technology transfer is presented to provide a basis for the methodology. The methodology is designed to: (1) identify medical problems and NASA technology that, in combination, constitute opportunities for successful medical products; (2) obtain the early participation of industry in the transfer process; and (3) obtain acceptance by the medical community of new medical products based on NASA technology. Two commercial transfers were completed: the ocular screening device, a system for quick detection of vision problems in preschool children, and Porta-Fib III, a hospital monitoring unit. Two institutional transfers were completed: implant materials testing, the application of NASA fracture control technology to improve reliability of metallic prostheses, and incinerator monitoring, a quadrupole mass spectrometer to monitor combustion products of municipal incinerators. Mobility aids for the blind and ultrasound diagnosis of burn depth are also studied.

  12. Attenuated radon transform: theory and application in medicine and biology

    Energy Technology Data Exchange (ETDEWEB)

    Gullberg, G.T.

    1979-06-01

    A detailed analysis is given of the properties of the attenuated Radon transform and of how increases in photon attenuation influence the numerical accuracy and computation efficiency of iterative and convolution algorithms used to determine its inversion. The practical applications for this work involve quantitative assessment of the distribution of injected radiopharmaceuticals and radionuclides in man and animals for basic physiological and biochemical studies as well as clinical studies in nuclear medicine. A mathematical structure is developed using function theory and the theory of linear operators on Hilbert spaces which lends itself to better understanding the spectral properties of the attenuated Radon transform. The continuous attenuated Radon transform reduces to a matrix operator for discrete angular and lateral sampling, and the reconstruction problem reduces to a system of linear equations. For the situation of variable attenuation coefficient frequently found in nuclear medicine applications of imaging the heart and chest, the procedure developed in this thesis involves iterative techniques of performing the generalized inverse. For constant attenuation coefficient less than 0.15 cm/sup -1/, convolution methods can reliably reconstruct a 30 cm object with 0.5 cm resolution. However, for high attenuation coefficients or for the situation where there is variable attenuation such as reconstruction of distribution of isotopes in the heart, iterative techniques developed in this thesis give the best results. (ERB)

  13. 50 CFR 260.50 - Suspension or revocation of license of licensed sampler or licensed inspector.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Suspension or revocation of license of... Licensing of Samplers and Inspectors § 260.50 Suspension or revocation of license of licensed sampler or... or evidence that he may wish to offer as to why his license should not be suspended or revoked....

  14. 77 FR 4806 - Eugene Water and Electric Board; Notice of Application for Surrender of License and Soliciting...

    Science.gov (United States)

    2012-01-31

    ... Energy Regulatory Commission Eugene Water and Electric Board; Notice of Application for Surrender of... Water and Electric Board. e. Name of Project: Blue River Project. f. Location: The proposed project... construction on October 28, 1993, by signing a contract for the manufacture of generating units and making...

  15. 15 CFR Appendix 1 to Part 960 - Filing Instructions and Information To Be Included in the Licensing Application

    Science.gov (United States)

    2010-01-01

    ... related documents shall be filed with the Assistant Administrator, National Environmental Satellite, Data... information shall be filed by the applicant in order to evaluate its suitability to hold a private remote... sensor (IFOV, in-track, cross-track); (6) On-board storage capacity; (7) Navigation...

  16. 75 FR 69063 - Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-11-10

    ... Energy Regulatory Commission Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application... 22, 2010, Port Bailey Wild Enterprises, LLC (transferor) and PB Energy, Inc. (transferee) filed a.... Shane II and Anita Shane, PB Energy, Inc., P.O. Box KPY, Kodiak, AK 99697, (360) 989-9843...

  17. 76 FR 7831 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-02-11

    ...: Grand River Dam Authority. e. Name of Project: Markham Ferry Project. f. Location: The project is located on the Grand River (also known as the Neosho River) in Mayes County, Oklahoma. g. Pursuant to... Energy Regulatory Commission Grand River Dam Authority; Notice of Application for Amendment of...

  18. 18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

    Science.gov (United States)

    2010-04-01

    ... show system transmission elements in relation to the project and other principal interconnected system... structural movement or stress, seepage, uplift, equipment failure, or water conduit failure, including a... redistribution of power flows on line loading (with respect to applicable thermal, voltage, or stability...

  19. Effects of Magnetic Field on Biological Cells and Applications

    Science.gov (United States)

    Chen, Ching-Jen

    2001-03-01

    While there has been extensive research performed in the physics of magnetic fields and the physics and chemistry in life sciences, independent of each other, there has been a paucity of scientific research and development investigating the possible applications of magnetic fields in life sciences. The focus of this presentation is to present the stimulation mechanism by which magnetic fields affect (a) yeast cells (b) plant cells and (c) mammalian normal and cancer cells. Recently we have found that the Saccharomyces Cerevsa yeast growth increases by about 30to a 1 tesla field and the production of CO2 increases by about 30of yeast metabolism may be due to an increase in intercellular interaction and protein channel alignment, the introduction of an alteration in the DNA from the magnetic field exposure or a combination of these mechanisms. We also have found that the application of high magnetic fields (1 tesla and above) can have marked effects on the germination and growth of plants, especially corn, beans and peas. This finding has opened up the possibility of technology developments in botanical growth systems to accelerate seed germination and crop harvesting. Most recently we have investigated the application of high magnetic fields on leukemia, CaCoII and HEP G2 cancer cell lines. We found that when leukemia are exposed to a 12 tesla field for 2 hours has an increase in cell death by about 30that were not exposed to the magnetic field. Viability of CaCoII cells sandwiched between permanent magnets of maximum strength of 1.2 tesla was measured. A decrease in viable cells by 33unexposed cells. HSP 70 was measured for HEPG2 cells that were exposed to permanent magnetic field of 1.2 tesla for 40 minutes and for unexposed cells. It was found that the exposed cells produce 19 times more HSP70 compared to unexposed cells. Our results together with other investigators report suggest a strong evidence of a reduction in the cell growth rate for cancer cells when

  20. 75 FR 4570 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing..., Program in Physical Biology, Section on Intracellular Interactions, is seeking statements of capability...