WorldWideScience

Sample records for biologics license applications

  1. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  2. IRIS pre-application licensing

    International Nuclear Information System (INIS)

    Carelli, Mario D.; Kling, Charles L.; Ritterbusch, Stanley E.

    2003-01-01

    This paper presents the approach to pre-application licensing by the International Reactor Innovative and Secure (IRIS), and advanced, integral reactor design with a thermal power of 1000 MW. The rationale for the pre-application licensing is discussed. Since IRIS technology is based on proven LWR experience, the project will rely on AP600/AP1000 precedent and will focus during the pre-application on long lead and novel items. A discussion of the evolution of the project to significantly reduce licensing issues is provided, followed by a summary of the IRIS safety-by-design which provides a formidable first step in the Defense in Depth approach. The effects of the safety-by-design, as well as of passive systems, on the IRIS safety will be investigated in a proposed testing program that will be reviewed by NRC during the pre-application. Documentation to be provided to NRC is discussed. Early design analyses indicate that the benefits of the IRIS safety-by-design approach are so significant that the basic premise of current emergency planning regulations (i.e., likelihood of core damage) will be reduced to the extent that special emergency response planning beyond the exclusion area boundary may not be needed. How this very significant outcome can be effected through a highly risk-informed licensing is discussed. (author)

  3. 14 CFR 431.73 - Continuing accuracy of license application; application for modification of license.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Continuing accuracy of license application; application for modification of license. 431.73 Section 431.73 Aeronautics and Space COMMERCIAL SPACE... Conditions § 431.73 Continuing accuracy of license application; application for modification of license. (a...

  4. Patterns of use and impact of standardised MedDRA query analyses on the safety evaluation and review of new drug and biologics license applications.

    Science.gov (United States)

    Chang, Lin-Chau; Mahmood, Riaz; Qureshi, Samina; Breder, Christopher D

    2017-01-01

    Standardised MedDRA Queries (SMQs) have been developed since the early 2000's and used by academia, industry, public health, and government sectors for detecting safety signals in adverse event safety databases. The purpose of the present study is to characterize how SMQs are used and the impact in safety analyses for New Drug Application (NDA) and Biologics License Application (BLA) submissions to the United States Food and Drug Administration (USFDA). We used the PharmaPendium database to capture SMQ use in Summary Basis of Approvals (SBoAs) of drugs and biologics approved by the USFDA. Characteristics of the drugs and the SMQ use were employed to evaluate the role of SMQ safety analyses in regulatory decisions and the veracity of signals they revealed. A comprehensive search of the SBoAs yielded 184 regulatory submissions approved from 2006 to 2015. Search strategies more frequently utilized restrictive searches with "narrow terms" to enhance specificity over strategies using "broad terms" to increase sensitivity, while some involved modification of search terms. A majority (59%) of 1290 searches used descriptive statistics, however inferential statistics were utilized in 35% of them. Commentary from reviewers and supervisory staff suggested that a small, yet notable percentage (18%) of 1290 searches supported regulatory decisions. The searches with regulatory impact were found in 73 submissions (40% of the submissions investigated). Most searches (75% of 227 searches) with regulatory implications described how the searches were confirmed, indicating prudence in the decision-making process. SMQs have an increasing role in the presentation and review of safety analysis for NDAs/BLAs and their regulatory reviews. This study suggests that SMQs are best used for screening process, with descriptive statistics, description of SMQ modifications, and systematic verification of cases which is crucial for drawing regulatory conclusions.

  5. Patterns of use and impact of standardised MedDRA query analyses on the safety evaluation and review of new drug and biologics license applications.

    Directory of Open Access Journals (Sweden)

    Lin-Chau Chang

    Full Text Available Standardised MedDRA Queries (SMQs have been developed since the early 2000's and used by academia, industry, public health, and government sectors for detecting safety signals in adverse event safety databases. The purpose of the present study is to characterize how SMQs are used and the impact in safety analyses for New Drug Application (NDA and Biologics License Application (BLA submissions to the United States Food and Drug Administration (USFDA.We used the PharmaPendium database to capture SMQ use in Summary Basis of Approvals (SBoAs of drugs and biologics approved by the USFDA. Characteristics of the drugs and the SMQ use were employed to evaluate the role of SMQ safety analyses in regulatory decisions and the veracity of signals they revealed.A comprehensive search of the SBoAs yielded 184 regulatory submissions approved from 2006 to 2015. Search strategies more frequently utilized restrictive searches with "narrow terms" to enhance specificity over strategies using "broad terms" to increase sensitivity, while some involved modification of search terms. A majority (59% of 1290 searches used descriptive statistics, however inferential statistics were utilized in 35% of them. Commentary from reviewers and supervisory staff suggested that a small, yet notable percentage (18% of 1290 searches supported regulatory decisions. The searches with regulatory impact were found in 73 submissions (40% of the submissions investigated. Most searches (75% of 227 searches with regulatory implications described how the searches were confirmed, indicating prudence in the decision-making process.SMQs have an increasing role in the presentation and review of safety analysis for NDAs/BLAs and their regulatory reviews. This study suggests that SMQs are best used for screening process, with descriptive statistics, description of SMQ modifications, and systematic verification of cases which is crucial for drawing regulatory conclusions.

  6. Review process for license renewal applications

    International Nuclear Information System (INIS)

    Craig, John W.; Kuo, P.T.

    1991-01-01

    In preparation for license renewal reviews, the Nuclear Regulatory Commission has recently published for public review and comment a proposed rule for license renewal and a draft Standard Review Plan as well as a draft Regulatory Guide relating to the implementation of the proposed rule. In support of future license renewal applications, the nuclear industry has also submitted 11 industry reports for NRC review and approval. This paper briefly describe how these parallel regulatory and industry activities will be factored into the NRC review process for license renewal. (author)

  7. 21 CFR 515.10 - Medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Medicated feed mill license applications. 515.10... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.10 Medicated feed mill license applications. (a) Medicated feed mill license applications (Forms FDA 3448) may...

  8. Personality traits of Turkish handgun license applicants.

    Science.gov (United States)

    Selek, Salih; Can, Serdar S; Yabanoglu, Ihsan

    2012-10-01

    Several theories have sought to explain the motivations for handgun possession and the relationship with personality. Perception of handguns also has cultural variations. The aim of the study is to evaluate handgun license applicants' personality profiles. 109 handgun license applicants were included in the study. Temperament and Character Inventory (TCI) scores of the applicants were recorded. Scores were compared with Turkish and American normative data for the Inventory. The study group had significantly lower subscores on novelty seeking, harm avoidance, and higher subscores on reward dependence and persistence compared to Turkish norms and significantly lower subscores on novelty seeking, reward dependence, and self-directedness compared to American norms. Results indicate that Turkish handgun license applicants' personality features are more similar to American norms.

  9. 9 CFR 102.4 - U.S. Veterinary Biologics Establishment License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biologics... LICENSES FOR BIOLOGICAL PRODUCTS § 102.4 U.S. Veterinary Biologics Establishment License. (a) Before a U.S. Veterinary Biologics Establishment License will be issued by the Administrator for any establishment, an...

  10. 75 FR 46938 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-04

    ... Logistics LLC (NVO), 120 S. Woodland Blvd., 216, DeLand, FL 32720, Officers: Dietmar Lutte, Manager Member, (Qualifying Individual), Susan Lutte, Member, Application Type: New NVO License. Bridgeline Logistics..., (Qualifying Individual), Application Type: New OFF License. [[Page 46939

  11. 75 FR 72824 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-26

    ... & OFF License. Everglory Logistics, Inc. (NVO & OFF), 440 McClellan Highway, 105F2, East Boston, MA..., Application Type: New NVO & OFF License. Hawaii Intermodal Tank Transport, LLC (NVO & OFF), 2350 S. Dock... Tran, Manager, Application Type: New NVO & OFF License. ITL USA Inc. dba International Transport...

  12. 75 FR 80499 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-12-22

    ... Individual), Jeffrey Cullen, President. Application Type: QI Change. Cala Distribution, LLC (NVO), 2705 NW..., (Qualifying Individual), William S. Askew, Manager. Application Type: New NVO License. Encar Trading, Corp...

  13. 9 CFR 102.5 - U.S. Veterinary Biological Product License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biological Product... BIOLOGICAL PRODUCTS § 102.5 U.S. Veterinary Biological Product License. (a) Authorization to produce each biological product shall be specified on a U.S. Veterinary Biological Product License, issued by the...

  14. 78 FR 20106 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-03

    ... M. Tsai, President (QI). Application Type: New NVO License. American International Shipping Company... Type: New NVO License. Nippon Concept America, LLC (OFF), 2203 Timberloch Place, Suite 218D, The...

  15. 21 CFR 310.4 - Biologics; products subject to license control.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Biologics; products subject to license control... to license control. (a) If a drug has an approved license under section 351 of the Public Health.... (b) To obtain marketing approval for radioactive biological products for human use, as defined in...

  16. 77 FR 59193 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-09-26

    ... Type: New OFF License. Bring Logistics US, Inc. (NVO & OFF), 4500 N. Sam Houston Parkway W., 130...: New NVO & OFF License. Contract Logistics, LLC (NVO & OFF), 4911 N. Portland Avenue, Suite 200.... Roush, Manager, Application Type: New NVO & OFF License. Crescent Line Inc. dba Globe Express Services...

  17. 76 FR 70145 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-10

    ...). Application Type: New NVO License. Alomar Transport, Inc. (NVO & OFF), 150-30 132nd Avenue, Suite 303, Jamaica... & OFF License. Forward System Logistics Inc. (NVO), 144-54 156th Street, Jamaica, NY 11434. Officers... NVO License. Green Line Shipping & Logistics Services Inc. (NVO & OFF), 16230 Lake View Lane, Apple...

  18. Application of up-front licensing

    International Nuclear Information System (INIS)

    Grant, S.D.; Snell, V.G.

    1995-01-01

    AECL has been pioneering 'up-front' licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs

  19. Application of up-front licensing

    Energy Technology Data Exchange (ETDEWEB)

    Grant, S D [Atomic Energy of Canada Ltd., Saskatoon, SK (Canada); Snell, V G [Atomic Energy of Canada Ltd., Mississauga, ON (Canada)

    1996-12-31

    AECL has been pioneering `up-front` licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs.

  20. 75 FR 20997 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-04-22

    ... 77354. Officers: Thomas C. Gaze, President, Qualifying Individual). Lori L. Gaze, Secretary/Treasurer... Services, (Qualifying Individual). George T. Cook, President/Treasurer, Application Type: New OFF License...

  1. 25 CFR 141.9 - Application for license renewal.

    Science.gov (United States)

    2010-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES BUSINESS PRACTICES ON... the applicant has made as a reservation business owner and the applicant's present fitness to reside... pending consideration of application for license renewal. (c) Prior to expiration of the existing license...

  2. LTO License Application Project NPP Borssele

    International Nuclear Information System (INIS)

    Jong, A.E. de; Blom, F.J.; Leilich, J.

    2012-01-01

    Borssele NPP plans to extend its operating life with 20 years until 2034. Borssele has started the project LTO 'bewijsvoering' (LTO 'Justification') in order to meet the requirements of the Dutch regulator. The outline of the project is based on IAEA safety guide 57 'Safe Long Term Operation of Nuclear Power Plants'. This paper describes the contents and coherence of the different parts in the project and how these respond to the IAEA guidelines on LTO. The goal of the project LTO 'bewijsvoering' is to ensure that safety and safety relevant systems, structures and components continue to perform their intended functions during long term operation. The outcome of the project LTO 'bewijsvoering' will be used for a license change application and this will be submitted to the Dutch regulator KFD for approval of prolonged operation of Borssele NPP after 2013. (author)

  3. 77 FR 20398 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-04-04

    ...), Svi Soudai, Manager, Application Type: New OFF License. Armada USA, LLC dba Armada Logistics (NVO... Logistics (NVO & OFF), 435 Division Street, Elizabeth, NJ 07076, Officer: Carlos E. Feliu, President.../Treasurer, (Qualifying Individual), Application Type: New NVO License. HYC Logistics, Inc. (NVO & OFF), 2600...

  4. 76 FR 44330 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-25

    .... Nguyen, Secretary/CFO, Application Type: New NVO & OFF License. Atlas Logistics LLC (NVO & OFF), 2801 NW...), Application Type: New NVO & OFF License. Bulk Cargo Services & Logistics Inc. (OFF), 15400 N.E. 103rd Drive..., Member/Chief Executive Manager, (Qualifying Individual), Stina Storr, Member/ Managing Member...

  5. 77 FR 24712 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-25

    ... Global Logistics LLC (OFF), 9816 Whithorn Drive, Suite B, Houston, TX 77095, Officer: Herbert R. Hogg, Operating Manager (Qualifying Individual), Application Type: New OFF License. Toyo Logistics America, Inc... Individual), Application Type: New NVO License. Choiceone Logistics, Inc. (NVO & OFF), 10025 NW 116th Way, 17...

  6. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-06

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . Action One Logistics, Inc..., Operating Manager (QI), Joseph Lam, Member, Application Type: New NVO License. Altex US, LLC (NVO & OFF), 1... President, Application Type: New NVO & OFF License. Andes Logistics USA LLC (NVO & OFF) 7500 NW 25 Street, 7...

  7. 76 FR 79682 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-22

    ... at (202) 523-5843 or by email at [email protected] . A.C.T. Logistics, LLC (NVO), 154-09 146th Avenue, 3rd...-President/Secretary. Application Type: License Transfer. Canyon Global Logistics, LLC (NVO & OFF), 2928-B..., General Manager, (Qualifying Individual), Oleg Ardachev, President. Application Type: New OFF License...

  8. 75 FR 61757 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-10-06

    ...), Jinho Um, CFO. Application Type: New NVO & OFF License. Junction Int'l Logistics, Inc. (NVO), 17870 Castleton Street, Suite 107, City of Industry, CA 91748. Officers: Charles Kuo, Secretary (Qualifying.... Application Type: New NVO & OFF License. Red Arrow Consulting, Inc. dba Red Arrow Logistics (OFF), 14925 SE...

  9. 76 FR 30360 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-05-25

    .... Application Type: Trade Name Change. B&O Logistics, Inc. (NVO), 19310 Pacific Gateway Drive, Torrance, CA.... Application Type: New NVO License. Charity Cargo L.L.C. (NVO & OFF), 1423 Kaleilani Street, Pearl City, HI... License. GreenLine Trade, LLC dba GreenLine Logistics (OFF), 14205 SE 36th, Suite 100, Bellevue, WA 98006...

  10. 77 FR 71002 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-28

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . 5G Logistics Solutions LLC..., President. Application Type: New NVO & OFF License. Bennett International Transport, L.L.C. (NVO & OFF.... Castano, COO. Application Type: New NVO & OFF License. James J. Boyle & Co. dba JJB Global Logistics Co...

  11. 78 FR 6325 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-01-30

    .... Application Type: New NVO & OFF License. Naca Logistics (USA), Inc. dba Brennan International Transport, dba...). Application Type: New NVO & OFF License. Miami Freight & Logistics Services, Inc. (NVO & OFF), 3630 NW 76th... World Shipping, dba OWS, dba Ocean Express, dba Oceanexpress Vanguard Logistics Services, dba Vanguard...

  12. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-02-17

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified.

  13. NUCLEAR SAFETY DESIGN BASES FOR LICENSE APPLICATION

    International Nuclear Information System (INIS)

    Garrett, R.J.

    2005-01-01

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111 [DIRS 156605] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113 [DIRS 156605] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period

  14. Nuclear Safety Design Base for License Application

    International Nuclear Information System (INIS)

    R.J. Garrett

    2005-01-01

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111(b) [DIRS 173273] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113(b) and (c) [DIRS 173273] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period

  15. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    International Nuclear Information System (INIS)

    Garrett, R.J.

    2005-01-01

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified

  16. PROCESS FOR LICENSE APPLICATION DEVELOPMENT FOR THE GEOLOGIC REPOSITORY

    International Nuclear Information System (INIS)

    DOUGLAS M. FRANKS AND NORMAN C. HENDERSON

    1997-01-01

    The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the U.S. Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, (section)60.21ff and (section)60.31ff. This paper discusses the process the Yucca Mountain Site Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the ''Technical Guidance Document for Preparation of the License Application'' (TGD), currently in development

  17. Process for license application development for the geologic repository

    International Nuclear Information System (INIS)

    Franks, D.M.; Henderson, N.C.

    1998-01-01

    The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the US Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, section 60.21ff and section 60.31ff. This paper discusses the process the Yucca Mountain Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the Technical Guidance Document for Preparation of the License Application (TGD), currently in development

  18. 75 FR 48686 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-11

    ...: New NVO License. Maritime and Intermodal Logistics Systems, Inc. dba MILS dba Fesco Integrated..., Senior Vice President/General Manager (Qualifying Individual), Kenryo Senda, President/CEO, Application...: New NVO & OFF License. Rado International, Inc. dba Rado Logistics (NVO & OFF), 2251 Sylvan Road...

  19. 77 FR 18815 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-28

    ... NVO License. American Patriot Lines, Inc. dba Tier One Logistics (NVO), 8616 La Tijera Boulevard, 401..., AL 36608. Officer: Samford T. Myers, Manager (Qualifying Individual). Application Type: New NVO & OFF License. Bluesea Logistics Corporation (NVO), 327 Elizabeth Avenue, Apt. A, Monterey Park, CA 91755-2044...

  20. 15 CFR 748.9 - Support documents for license applications.

    Science.gov (United States)

    2010-01-01

    ... licensing action, since end-uses and other considerations are important factors in the decision making... promptly notifying BIS of any change in the facts contained in the support document that comes to your attention. (h) Effect on license application review. BIS reserves the right in all respects to determine to...

  1. 77 FR 43599 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-07-25

    ... OFF License. Logistics International Parcel Shipping Transport LLC (NVO), 182 West Melrose Avenue, 2... Schwartz, Director, Application Type: New OFF License. Brox Logistics USA, LLC (NVO,) 244 5th Avenue, V-280... Agency Corporation, dba C&F Worldwide Logistics. Cargois Inc. dba Star Vision Logis (NVO), 2700 Coyle...

  2. 76 FR 28778 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-05-18

    ... Individual), Application Type: New NVO & OFF License. Asian Link Logistics, LLC dba Best Global (NVO & OFF... Type: New NVO License. Hansa Meyer Global Transport USA, LLC dba Hansa Shipping LLC, (OFF), 712 Main... & Logistics (Private) Limited dba, Nashrah Shipping and Logistics (NVO), Mezzanine Floor, Trade Ave., Tower 1...

  3. Fort Calhoun Station, Unit 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    1975-09-01

    Application for construction and operating licenses for Calhoun-2 Reactor is presented. Financial data concerning the Omaha Public Power District and the Nebraska Public Power District are included. (DCC)

  4. 76 FR 47182 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-08-04

    ... Street, Tampa, FL 33619, Officers: Margara L. Barillas, President (Qualifying Individual), Danihel I. Barillas, Secretary, Application Type: New NVO License. Russell A. Farrow (U.S.) Inc. (OFF & NVO), 4950...

  5. 77 FR 72863 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-12-06

    ... & D Transport, Inc. (NVO & OFF), 4869 Peavey Drive, Meridian, MS 39301. Officers: Uros Pejanovic, Vice... Nucete, Director. Application Type: New NVO & OFF License. Embarque Los Hidalgos LLC (NVO & OFF), 326...

  6. 77 FR 12583 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-01

    ... Hermo, Vice President, Application Type: New NVO & OFF License. B2B Global Logistics Incorporated (NVO... Change. Global Logistics New Jersey Limited Liability Company (NVO & OFF) 275 Veterans Boulevard...

  7. 77 FR 64991 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-24

    ..., Manager/Member. Application Type: New NVO & OFF License. Hospitality Logistics International LLC (NVO...), 11690 NW. 105th Street, Law 4W, Miami, FL 33178. Officers: Chris Merritt, Vice President (QI), John H...

  8. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    .... Forth-Matthews, President, Application Type: New OFF License. Azimuth Lines Inc. (OFF), 111 Ivy Lane.... (NVO), 1000 Lakes Drive, 260, West Covina, CA 91760, Officers: Larry Lee, Treasurer (Qualifying...

  9. 75 FR 67973 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-04

    ... Individual), Joy V. Pareckattil, President/Director, Application Type: New NVO License. CJC Logistics Limited Liability Company dba CJC Container Line (NVO & OFF), 186 Alps Road, Wayne, NJ 07470. Officers: Oliver Rosca...

  10. 76 FR 78007 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-15

    ..., (Qualifying Individual), Ruba Hindi, Member, Application Type: New OFF License. Kemka USA Limited Liability Company (NVO & OFF), 421 Lucy Court, South Plainfield, NJ 07080, Officer: Hsiang (Rita) Y. Hsiao, Member...

  11. 77 FR 70162 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-23

    ...), 900 Center Park Drive, Suite F, Charlotte, NC 28217, Officers: Paul L. Carter, Vice President (QI...), Application Type: New NVO License. Transport Partner (USA), Inc. (NVO & OFF), 2006 Cherry Hill Lane...

  12. 78 FR 38336 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-26

    ..., President (QI), Stephen B. Schwark, Treasurer, Application Type: License Transfer to EFL Container Lines...., Suite K, Mobile, AL 36609, Officers: Thomas (Mac) H. McPhillips IV, Assistant Vice President (QI), Oscar...

  13. 76 FR 23598 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-27

    ... Angeles, CA 90045, Officers: Ann L. Shang, CFO (Qualifying Individual), Yon L. Li, President, Application... Type: New NVO & OFF License. PME Logistics, Inc. (NVO), 19401 S. Main Street, Suite 102, Gardena, CA...

  14. 76 FR 56759 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-09-14

    ...), Ariel S. Villamayor, Limited Partner, Application Type: New OFF License. UTi, United States, Inc. dba UTi (NVO & OFF), 1660 Walt Whitman Road, Melville, NY 11747. Officers: Charles N. Deller, Vice...

  15. License application approach for the California LLRW disposal facility

    International Nuclear Information System (INIS)

    Gaynor, R.K.; Romano, S.A.; Hanrahan, T.P.

    1990-01-01

    US Ecology, Inc. is the State of California's license designee to site, develop and operate a low-level radioactive waste (LLRW) disposal facility to serve member states of the Southwestern Compact. US Ecology identified a proposed site in the Ward Valley of southeastern California in March 1988. Following proposed site selection, US Ecology undertook studies required to prepare a license application. US Ecology's license application for this desert site was deemed complete for detailed regulatory review by the California Department of Health Services (DHS) in December 1989. By mutual agreement, disposal of mixed waste is not proposed pending the State of California's decision on appropriate management of this small LLRW subset

  16. 10 CFR 781.62 - Contents of a license application.

    Science.gov (United States)

    2010-01-01

    ... royalty fees or other consideration, if any, that the applicant would be willing to pay the Government for... application. An application for a license under a DOE invention must be accompanied by a processing fee of $25... towards royalty if royalties are charged, and must include the following information: (a) Identification...

  17. 78 FR 17205 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-20

    .... Sicilia, Member, Application Type: New NVO & OFF License. Brookfield Relocation Inc. (OFF), Two Corporate... Schwartz, President, Application Type: QI Change. Covenant Global Logistics Inc (NVO & OFF), 440 Benmar..., President, Application Type: Add Trade Name CGL Shipping. EXL Logistics, Inc. (NVO), 1444 NW 82nd Avenue...

  18. 78 FR 75345 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-11

    .... Romero, President (QI). Application Type: New NVO & OFF License. F.H.L. Logistics, Inc. (NVO & OFF), 1354.... Officers: Arif H. Butt, General Manager (QI), Unni Krishnan Nair, President. Application Type: New NVO...: Stephen F. Crooks, Vice President (QI), Scott Kelly, President. Application Type: Adding NVO Service...

  19. 76 FR 22104 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-20

    ...), Application Type: Business Structure Change Foothills Logistics, Inc. (NVO), 2045 John Crosland Jr. Way... Individual), Daniel Gelpi, President, Application Type: Add NVO Service ADM Logistics, Inc. (NVO & OFF), 4666... (Qualifying Individual), Application Type: New NVO & OFF License ATC Logistics, Inc. (NVO & OFF), 14350...

  20. 78 FR 50054 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-16

    ...), Ross V. Stemmler, President, Application Type: QI Change. Dawson Logistics, Inc. (OFF), 2220 South... (QI), Chad Earwood, President, Application Type: Add NVO Service. Fesco Integrated Transport North...), Ugochukwu O. Ene, President, Application Type: New NVO & OFF License. Icon Logistics Services LLC (OFF...

  1. 78 FR 55698 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-11

    ...), Karla Costilla, Member/Manager, Application Type: New NVO & OFF License. ICAT Logistics, Inc. (OFF..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . Abaco Logistics Corporation..., CFO, Application Type: QI Change & Add OFF Service. American General Logistics, Inc. (NVO), 626 N...

  2. 77 FR 37044 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-20

    ... 95695, Officer: Nasrullah Chaudhry, Member/Manager (Qualifying Individual), Application Type: Add NVO... (Qualifying Individual), Margaret Kong, CFO/Secretary, Application Type: New NVO & OFF License. FSG Logistics (USA), Inc. dba FSG Logistics, Inc. (NVO & OFF), 27013 Pacific Highway South, PMB386, Des Moines, WA...

  3. 78 FR 48435 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-08

    ... Change. Ever Line Logistics Inc. (NVO & OFF), 147-35 Farmers Blvd., Suite 208, Jamaica, NY 11434, Officer: Caihong Yang, President (QI), Application Type: Name Change to Bona Logistics US Inc. Global Container.... Bote, Member/Manager, Edgar T. Bote, Member/Manager, Application Type: New NVO License. National Air...

  4. 76 FR 55909 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-09-09

    ..., LLC dba AIM Global Logistics (NVO & OFF), 6402 Teluco Street, Houston, TX 77055, Officer: Angelica Garcia-Dunn, Manager/President/Treasurer (Qualifying Individual), Application Type: New OFF & NVO License... Individual), Application Type: Name Change. BestOcean Worldwide Logistics, Inc. (NVO & OFF), 1300 Valley...

  5. 78 FR 18592 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-27

    ...), Veronica Alcestte, Manager, Application Type: New NVO & OFF License Worldcraft Logistics LLC (NVO & OFF.... Salvat, Vice President, Application Type: Add NVO Service Bayshore Logistics & Services, LLC (NVO & OFF), 909 Westfield Avenue, Elizabeth, NJ 07208, Officers: Raquel Velez, Operating Manager (QI), Jose Moreno...

  6. 76 FR 62407 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-07

    ... & Product Logistics Manager (Qualifying Individual), Thomas B. Crowley, Director, Application Type: QI... at (202) 523-5843 or by e-mail at [email protected] . Alltransport International Logistics, Inc. (NVO), 63... Individual), Application Type: New NVO License. American Global Logistics LLC dba AGL (NVO & OFF), 3399...

  7. 78 FR 14792 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-07

    ...: Mohamed Y. Ali, Manager (QI); Abdul S. Mohamed, Member. Application Type: Add Trade Name Compass Logistics... Ugueto, Secretary. Application Type: New NVO & OFF License American Forwarding & Logistics, LLC (NVO & OFF), 1919 NW 19th Street, Unit 624, Ft. Lauderdale, FL 33311. Officers: Gabriele Awada, Manager (QI...

  8. 77 FR 45610 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-08-01

    ...), Richard A. Arkey, Vice President, Application Type: New NVO License. Aequus Worldwide Logistics Inc. (NVO..., Application Type: Name Change to Concepts in Freight, Inc. FGN Global Logistics, Inc. (NVO & OFF), 4770...), 341 Erickson Avenue, P.O. Box 124, Essington, PA 19029, Officers: Ari M. Bobrow, Export Manager...

  9. 10 CFR 81.40 - Contents of a license application.

    Science.gov (United States)

    2010-01-01

    ... categories: (i) Small business firm; (ii) Minority business enterprise; (iii) Location in a surplus labor... correspondence should be sent and any notices served; (4) Nature and type of applicant's business; (5...; (6) Purpose for which the license is desired, and a brief description of applicant's plan to achieve...

  10. 77 FR 40882 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-07-11

    ..., Director, Application Type: License Transfer & QI Change. Gulf Premier Logistics LLC (NVO & OFF), 340 N... & OFF), 1163 Fairway Drive, 106, City of Industry, CA 91789, Officer: XiuJi Zhang, President, (Qualifying Individual), Application Type: Add NVO Service. Simple Logistics Inc. (NVO), 147-35 Farmers...

  11. 77 FR 38288 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-27

    ..., President. Application Type: QI Change. Freight Logistics Services USA Forwarding Ltd (OFF), 15955 W. Hardy... Individual). Application Type: Add OFF Service. Pudong Prime Int'l Logistics, Inc. (NVO), 9660 Flair Drive... License. Benchmark Worldwide Logistics, Inc. dba Star Ocean Lines (NVO & OFF), 24900 South Route 53...

  12. 78 FR 48870 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-12

    ...: Tufan Duygun, Manager (QI), Ozisik Serhat, Member, Application Type: Add Trade Name Daimon Logistics USA. Logistics International Parcel Shipping Transport LLC (NVO), 391 Kent Avenue, Elk Grove, IL 60007, Officers...), Application Type: NVO & OFF License. Kesco Logistics, Inc. (NVO & OFF), 20 E. Sunrise Highway, Suite 308...

  13. 75 FR 57798 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-22

    ..., (Qualifying Individual). Application Type: New NVO & OFF License. Cambria Global Logistics, LLC (OFF), 12140...). Application Type: QI Change. K&K Express, LLC dba K2 Logistics (NVO & OFF), 2980 Commers Drive, 100, Eagan, MN... Global Transport (NVO), 8636 York Circle, La Palma, CA 90623. Officer: Smile Cha, Sole Proprietor...

  14. 76 FR 67730 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-02

    ..., President, Application Type: Name Change/Trade Name Change Lion Transport, Inc. dba Amex Logistics (NVO... Individual), Caetano R. Lopes, Vice President, Application Type: Add NVO Service Eztrans Logistics Ltd. (NVO... Type: New OFF License LF Freight USA LLC dba LF Logistics dba LF Freight dba IDS Logistics USA, dba IDS...

  15. 77 FR 30530 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-23

    ... Individual), Application Type: New NVO License. Global Wine Logistics, Inc. (NVO & OFF), 197 Route 19 South... Hextall, President/CEO, Application Type: Add NVO Service/Trade Name Change. M & D Global Logistics, Inc... Service. Metro Freight Services, Inc. dba Maritime Express Lines (M.E.L.) (NVO & OFF), 1225 W. St. George...

  16. 47 CFR 80.53 - Application for a portable ship station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a portable ship station license... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.53 Application for a portable ship station license. The Commission may grant a license permitting operation of a...

  17. 76 FR 6135 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-03

    ... Lawin Cargo dba, Bahaghari Express Cargo (NVO), 761 Highland Place, San Dimas, CA 91773, Officer..., Application Type: New NVO License. Four Points Ocean Inc. (NVO & OFF), 1460 Route 9 North, Suite 303.... Grannell, President/CEO (Qualifying Individual), Michael Kuhn, Vice President, Sales & Marketing...

  18. Fuel Receiving and Storage Station. License application, amendment 4

    International Nuclear Information System (INIS)

    1975-04-01

    Amendment No. 4 of the application for licensing the Barnwell Fuel Processing Plant is presented. Information is included on: the quantity and characteristics of nuclear fuel assemblies which can be received and stored; specifications limiting the outside washdown of contaminated casks received for unloading; and definition of environmental monitoring program. (U.S.)

  19. 78 FR 35634 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-13

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . China Interocean Transport.... Taleon, Sole Proprietor (QI). Application Type: New NVO & OFF License. Dulce Auto Import & Export, Inc...), Parque de Granada No. 71, P.H. 504, Huixquilucan, Estado de Mexico 52785 Mexico. Officers: Moises S. Leon...

  20. 76 FR 3636 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-01-20

    ..., Vice President, Application Type: New NVO & OFF License. CDS Global Logistics, Inc. (NVO & OFF), 1001... & Logistics LLC (NVO & OFF), Hoboken Business Center, 50 Harrison Street, Suite 204B, Hoboken, NJ 07030, Officers: Michelle L. Hasenauer, Manager (Qualifying Individual), Harbans S. Shrinkant, Manager...

  1. 77 FR 65887 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-31

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . ACM Logistics & Consulting... Type: New OFF License; Highland Project Logistics, Inc. (NVO & OFF), 35 Constitution Drive, Suite A.... Bonner, Special Manager (QI), Martine L. Plunkett, Manager, Application Type: Additional QI; Radiant...

  2. 76 FR 41258 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-13

    ... Individual), Gediminas Garmus, Member/Manager. Application Type: New OFF License. World Logistics USA, Inc... at (202) 523-5843 or by e-mail at [email protected] . 3 Plus Logistics Co. dba Touchdown Freight Co. (NVO... Logistics, Inc. (NVO), 3120 Via Mondo, Rancho Dominguez, CA 90220. Officer: Simon Hwang, President/CEO...

  3. 75 FR 35815 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-06-23

    ..., TX 76011. Officers: Omar Kolaghassi, Manager (Qualifying Individual), Laura Alicia, Manager. Application Type: New OFF & NVO License. CALS Logistics USA, Inc. (OFF & NVO), 755 North Route 83, Suite 215.... Premium Star Logistics LLC dba O.P. Premium Star Logistics (OFF & NVO), 4200 Lightning Court, Bakersfield...

  4. 77 FR 74186 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-12-13

    ... Logistics, Inc. (NVO & OFF), 7685 NW. 80th Terrace, Medley, FL 33166, Officers: Hugo E. Martinez, Secretary... & OFF), 1834 Harden Blvd., Lakeland, FL 33803, Officers: Steven C. Pniewski, Manager (QI), Manuel R. Echevarria, President, Application Type: New NVO & OFF License, Global Wide Logistics, Inc. (NVO), 1937 Davis...

  5. 78 FR 43202 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-07-19

    .... Alsea Global Logistics, LLC dba Alsea Global Logistics (NVO & OFF), 4836 SE Powell Blvd., Portland, OR... NVO & OFF License. Atlant Consulting Inc. dba Avro Logistics (NVO & OFF), 3626 Geary Blvd., Suite 206..., Officers: Paul Selvage, Member (QI), Steven Periman, Member/Manager, Application Type: Add Trade Name Blu...

  6. 76 FR 14395 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-03-16

    ..., Manager/President. Application Type: QI Change. Geoffrey Au dba ABC Logistics Company (NVO), 2250 Gellert... at (202) 523-5843 or by e-mail at [email protected] . Arkman Logistics Inc. (NVO), 1001 Fargo Avenue, Elk... Type: New NVO & OFF License. BCargo Logistics, S.A. de C.V. (NVO), Av. Revolucion 725-A, Col. Jardin...

  7. 75 FR 29545 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-05-26

    .... Atlantic Cargo Logistics LLC (OFF & NVO), 120 South Woodland Blvd., 216, Deland, FL 32720. Officers: Dietmar Lutte, Manager, (Qualifying Individual) Susan Lutte, Member, Application Type: New OFF & NVO License. Direct Delivery Logistics and Supply, LLC (OFF & NVO) 2006 Wilson Road, Humble, TX 77396...

  8. 77 FR 35384 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-13

    ... Logistics LLC (NVO), 9814 Goldenglade Drive, Houston, TX 77064, Officer: Sandra Lesage, Member/Manager... telephone at (202) 523-5843 or by email at [email protected] . ABC Trucking and Logistics L.L.C. (OFF), 3080...), Lawrence R. Lammers, President/CEO, Application Type: License Transfer Atlantic Cargo Logistics LLC (NVO...

  9. 9 CFR 2.11 - Denial of initial license application.

    Science.gov (United States)

    2010-01-01

    ... have violated any Federal, State, or local laws or regulations pertaining to animal cruelty within 1... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Denial of initial license application. 2.11 Section 2.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT...

  10. 76 FR 7209 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-02-09

    ... 77032. Officer: Walter Krauklis, OTI Compliance Officer (Qualifying Individual), Thomas B. Crowley, Jr... Road, Suite 14, Newtown Square, PA 19073. Officer: Thomas D. Torcomian, CEO/ Member (Qualifying...). Application Type: New OFF License. Solomon Emeke dba Desaiah Limited (OFF), 3696 Park Avenue, 300, Ellicott...

  11. 76 FR 38651 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-07-01

    ... Shipping (NVO), 1861 Western Way, Torrance, CA 90501. Officers: Hseanrus (Stephen) H. Lin, President/Vice..., President, Application Type: New NVO & OFF License. F.H.L. Logistics, Inc. (NVO & OFF), 1354 NW 78th Avenue..., Gardena, CA 90248. Officers: Anna W. Liu, Vice President (Operations), (Qualifying Individual), Quincy H...

  12. 76 FR 33757 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-06-09

    ... NVO & OFF License. The Ultimate Logistics Service Corporation (NVO & OFF), 3 Birch Place, Pine Brook... Logistics, Corp. (NVO), 4713 Deeboyar, Lakewood, CA 90712. Officer: Tan Sek, Pres/VP/Sec/Treasurer...), Application Type: Add OFF Service. Oceanic Link USA LLC (NVO & OFF), 5430 Jimmy Carter Blvd., Suite 216...

  13. 77 FR 13604 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-07

    ... A. Rincon, Manager (Qualifying Individuals), Application Type: Business Structure Change. De Well... Type: New NVO License. King Solomon Logistics Inc. (NVO), 135-14 Liberty Avenue, South [[Page 13605... Logistics Inc. (NVO), 167-16 146th Avenue, Suite 203, Jamaica, NY 11434, Officer: Yau Fung Ling, President...

  14. 78 FR 60282 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-10-01

    ...) pursuant to section 19 of the Shipping Act of 1984 (46 U.S.C. 40101). Notice is also given of the filing of... Castleton Street, Suite 105, City of Industry, CA 91748, Officers: Ya Liu, Deputy General Manager (QI), Jian C. Feng, Director, Application Type: New NVO License, By the Commission. Dated: September 27, 2013...

  15. 77 FR 39707 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-07-05

    ..., Application Type: New OFF License. Best Global Logistics USA, Inc dba Siam Intercargo Services (NVO & OFF... International Transport, LLC (NVO), 6048 Lido Lane, Long Beach, CA 90803, Officer: Charles Brennan, Member...: Add NVO Service. Sinai Logistics LLC (NVO & OFF), 11419 NW. 112th Street, Medley, FL 33178, Officer...

  16. 76 FR 16420 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-03-23

    ...), Andrew P. Bottomley, Managing Partner, Application Type: QI Change and Add OFF Service. All Transport... Type: New NVO & OFF License. Andrea Bigi dba AB Global Logistics Consulting (OFF), 1010 19th Street, 10.... Officers: Joanne Kirkpatrick, International Logistics Officer (Qualifying Individual), Jack R. Lentz, CEO...

  17. 76 FR 65193 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-20

    ... at (202) 523-5843 or by e-mail at [email protected] . AB Global Logistics Consulting Inc. (OFF), 1010 19th..., Application Type: New NVO License. All Transport Export Inc (NVO & OFF), 4224 Shackleford Road, 3, Norcross... Type: Name Change. CR & J Logistics, Inc. (OFF), 8401 Lake Worth Road, Lake Worth, FL 33467. Officers...

  18. Application of coupled codes for safety analysis and licensing issues

    International Nuclear Information System (INIS)

    Langenbuch, S.; Velkov, K.

    2006-01-01

    An overview is given on the development and the advantages of coupled codes which integrate 3D neutron kinetics into thermal-hydraulic system codes. The work performed within GRS by coupling the thermal-hydraulic system code ATHLET and the 3D neutronics code QUABOX/CUBBOX is described as an example. The application of the coupled codes as best-estimate simulation tools for safety analysis is discussed. Some examples from German licensing practices are given which demonstrate how the improved analytical methods of coupled codes have contributed to solve licensing issues related to optimized and more economical use of fuel. (authors)

  19. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    1993-11-01

    This document is a compilation and source list of nuclear safety criteria that the Nuclear Regulatory Commission (NRC) applies to licensed reactors; it can be used by DOE and DOE contractors to identify NRC criteria to be evaluated for application to the DOE reactors under their cognizance. The criteria listed are those that are applied to the areas of nuclear safety addressed in the safety analysis report of a licensed reactor. They are derived from federal regulations, USNRC regulatory guides, Standard Review Plan (SRP) branch technical positions and appendices, and industry codes and standards

  20. Export Controls: Controls Over the Export Licensing Process for Chemical and Biological Items

    National Research Council Canada - National Science Library

    2005-01-01

    .... foreign policy should read this report. The report discusses the effectiveness of the DoD review process for export license applications and updates to Federal export regulations to prevent the proliferation of items that could pose...

  1. Fuel Receiving and Storage Station. License application, amendment 7

    International Nuclear Information System (INIS)

    1976-02-01

    Amendment No. 7 to Allied-General Nuclear Services application for licensing of the Fuel Receiving and Storage Station consists of revised pages for: Amendment No. 7 to AG-L 105, ''Technical Description in Support of Application for FRSS Operation''; Amendment No. 1 to AG-L 105A, ''Early Operation of the Service Concentrator''; and Amendment No. 2 to AG-L 110, ''FRSS Summary Preoperational Report.''

  2. 21 CFR 515.20 - Approval of medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Approval of medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.20 Approval of medicated feed mill license applications. Within 90 days after an...

  3. 21 CFR 515.21 - Refusal to approve a medicated feed mill license application.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Refusal to approve a medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.21 Refusal to approve a medicated feed mill license application. (a) The...

  4. 78 FR 37324 - Preparation of Environmental Reports for Nuclear Power Plant License Renewal Applications

    Science.gov (United States)

    2013-06-20

    ... Environmental Reports for Nuclear Power Plant License Renewal Applications AGENCY: Nuclear Regulatory Commission... for Nuclear Power Plant License Renewal Applications.'' This regulatory guide provides guidance to... renewal of a nuclear power plant operating license. Applicants should use this regulatory guide when...

  5. 47 CFR 87.47 - Application for a portable aircraft station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a portable aircraft station... SPECIAL RADIO SERVICES AVIATION SERVICES Applications and Licenses § 87.47 Application for a portable aircraft station license. A person may apply for a portable aircraft radio station license if the need...

  6. 76 FR 79203 - Prospective Grant of Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines

    Science.gov (United States)

    2011-12-21

    ... Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines AGENCY: National Institutes....7. The invention relates to compositions and methods of use as Veterinary Influenza Vaccines... to humans. This technology describes DNA vaccines against influenza serotypes H5N1, H1N1, H3N2, and...

  7. License renewal - an idea whose time has come. Hatch nuclear plant license renewal program: an actual example of application of the license renewal rule to the Intake Structure

    International Nuclear Information System (INIS)

    Chandiwala, F.; Evans, W.P.

    1999-01-01

    After the NRC issued a revised license renewal rule in May 1995, the nuclear industry focussed on developing generic industry for implementing the rule and testing the guidance through various demonstration programs and work products in conjunction with the NRC. In addition, plant-specific programs also proceeded forward. These activities show that implementation issues continue to exist. Since the issuance of the rule, the NRC has issued a draft standard review plan for license renewal (SRP-LR), working draft, September 1997. Southern Nuclear Operating Company (SNC) has begun development work on a license renewal application for Plant Hatch Units 1 and 2. Plant Hatch Units 1 and 2 are BWR 4, Mark I plants whose operating licenses expire in 2014 and 2018, respectively. The Plant Hatch initiative also involves teaming with other boiling water reactors (BWRs) to develop the license renewal technology within the BWR fleet, and to support Plant Hatch by providing an oversight role for the application process. The teaming effort involved two other utilities, each being assigned to prepare a common report on a mechanical system or a structure. The common report could be presented to the NRC with modifications to suit the individual plants, thereby saving time and money, and hopefully resulting in quicker approval by the NRC. The desired license renewal process end result is a renewed license with up to a 20 year extension (10CFR 54.31(b)). (orig.)

  8. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    1991-04-01

    The Department of Energy (DOE) Order DOE 5480.6, Safety of Department of Energy-Owned Nuclear Reactors, establishes reactor safety requirements to assure that reactors are sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that adequately protects health and safety and is in accordance with uniform standards, guides, and codes which are consistent with those applied to comparable licensed reactors. This document identifies nuclear safety criteria applied to NRC [Nuclear Regulatory Commission] licensed reactors. The titles of the chapters and sections of USNRC Regulatory Guide 1.70, Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants, Rev. 3, are used as the format for compiling the NRC criteria applied to the various areas of nuclear safety addressed in a safety analysis report for a nuclear reactor. In each section the criteria are compiled in four groups: (1) Code of Federal Regulations, (2) US NRC Regulatory Guides, SRP Branch Technical Positions and Appendices, (3) Codes and Standards, and (4) Supplemental Information. The degree of application of these criteria to a DOE-owned reactor, consistent with their application to comparable licensed reactors, must be determined by the DOE and DOE contractor

  9. 76 FR 65544 - Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities

    Science.gov (United States)

    2011-10-21

    ... NUCLEAR REGULATORY COMMISSION [NRC-2009-0323] Standard Format and Content of License Applications... revision to regulatory guide (RG) 3.39, ``Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities.'' This guide endorses the standard format and content for license...

  10. 21 CFR 515.11 - Supplemental medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Supplemental medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.11 Supplemental medicated feed mill license applications. (a) After approval of a medicated feed...

  11. Application to biological data

    Indian Academy of Sciences (India)

    Reduction of dimensionality has emerged as a routine process in modelling complex biological systems. A large number of feature selection techniques have been reported in the literature to improve model performance in terms of accuracy and speed. In the present article an unsupervised feature selection technique is ...

  12. License Application Design Selection Feature Report: Aging and Blending

    International Nuclear Information System (INIS)

    Coltoni, B.; Anderson, M.J.

    1999-01-01

    The purpose of this document is to evaluate the concepts of Aging and Blending for waste sent to the Monitored Geologic Repository (MGR). These design features are based on pre-emplacement treatment of the waste stream. The envelope of the analysis has been performed under the direction of the License Application Design Selection Team (LADST), which advocated utilizing the Viability Assessment (VA) repository design (DOE 1998c) as the basis. Therefore, this evaluation attempts to modify the VA design only to the extent that Aging and Blending can be accomplished. This modified VA design will be contrasted to the VA Design and the difference in design, costs, and performance will be presented

  13. 21 CFR 515.25 - Revocation of order refusing to approve a medicated feed mill license application or suspending...

    Science.gov (United States)

    2010-04-01

    ... medicated feed mill license application or suspending or revoking a license. 515.25 Section 515.25 Food and..., FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.25 Revocation of order refusing to approve a medicated feed mill license application or suspending or revoking a...

  14. 78 FR 21930 - Aquenergy Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2013-04-12

    ... Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process a. Type of Filing: Notice of Intent to File License...: November 11, 2012. d. Submitted by: Aquenergy Systems, Inc., a fully owned subsidiaries of Enel Green Power...

  15. SIMS applications in biological research

    International Nuclear Information System (INIS)

    Prince, K.E.; Burke, P.T.; Kelly, I.J.

    2000-01-01

    Full text: SIMS has been utilised as a tool for biological research since the early 1970's. SIMS' abilities in isotopic detection with high sensitivity, imaging capabilities at a subcellular level, and the possibility of molecular imaging have been the main areas of interest for biological development. However, whilst hundreds of instruments are available in industrial and university laboratories for semiconductor and materials analysis, only a handful successfully perform biological research. For this reason there is generally a lack of awareness of SIMS by the biological community. Biological SIMS analysis requires a working knowledge of both biology and SIMS. Sample preparation is a critical and time consuming prerequisite for any successful biological SIMS study. In addition, for quantification to be possible a homogeneous, matrix matched standard must be available. Once these difficulties are more widely understood and overcome there will be a greater motivation for the biological community to embrace SIMS as a unique tool in their research. This paper provides an overview of some of the more successful biological SIMS application areas internationally, and summarises the types of biological SIMS requests received by ANSTO

  16. Application and licensing requirements of the Framatome ANP RLBLOCA methodology

    International Nuclear Information System (INIS)

    Martin, R.P.; Dunn, B.M.

    2004-01-01

    The Framatome ANP Realistic Large-Break LOCA methodology (FANP RLBLOCA) is an analysis approach approved by the US NRC for supporting the licensing basis of 3- and 4-loop Westinghouse PWRs and CE 2x4 PWRs. It was developed consistent with the NRC's Code Scaling, Applicability, and Uncertainty (CSAU) methodology for performing best-estimate large-break LOCAs. The CSAU methodology consists of three key elements with the second and third element addressing uncertainty identification and application. Unique to the CSAU methodology is the use of engineering judgment and the Process Identification and Ranking Table (PIRT) defined in the first element to lay the groundwork for achieving the ultimate goal of quantifying the total uncertainty in predicted measures of interest associated with the large-break LOCA. It is the PIRT that not only directs the methodology development, but also directs the methodology review. While the FANP RLBLOCA methodology was generically approved, a plant-specific application is customized in two ways addressing how the unique plant characterization 1) is translated to code input and 2) relates to the unique methodology licensing requirements. Related to the former, plants are required by 10 CFR 50.36 to define a technical specification limiting condition for operation based on the following criteria: 1. Installed instrumentation that is used in the control room to detect, and indicate, a significant abnormal degradation of the reactor coolant pressure boundary. 2. A process variable, design feature, or operating restriction that is an initial condition of a design basis accident or transient analysis that either assumes the failure of or presents a challenge to the integrity of a fission product barrier. 3. A structure, system, or component that is part of the primary success path and which functions or actuates to mitigate a design basis accident or transient that either assumes the failure of or presents a challenge to the integrity of a

  17. Total System Performance Assessment-License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2002-09-13

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issue (KTI) agreements, the ''Yucca Mountain Review Plan'' (CNWRA 2002 [158449]), and 10 CFR Part 63. This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are utilized in this document.

  18. Total System Performance Assessment - License Application Methods and Approach

    International Nuclear Information System (INIS)

    McNeish, J.

    2003-01-01

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document

  19. License Application Design Selection Report, REV 01. August 1999

    International Nuclear Information System (INIS)

    Hastings, C.R.

    1999-01-01

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value as elements of a repository design. In Phase II

  20. Application of neutrons in biology

    International Nuclear Information System (INIS)

    Cser, L.

    1982-01-01

    Applications of neutron scattering to determine the structure of biological macromolecules are reviewed. A theoretical and experimental introduction to neutron scattering and its mathematical description is given. The analysis of crystal structure using neutron scattering and the problem of Fourier reconstruction of structure are discussed. Some special problems concerning biological materials are described. The isotope effect of neutron scattering is applied to determine and identify the hydrogen atoms in biological macromolecules. Some examples illustrating the structure determination of amino acids and proteins are given. Mathematical methods of evaluation of small angle neutron scattering experiments and applications to investigate E. coli ribosome are described. New developments and new research trends are also reviewed. (D.Gy.)

  1. 77 FR 70837 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-11-27

    ... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... request: The proposed change will delete Function 14, SG [Steam Generator] Water Level--Low, Coincident... capability to shut down the reactor when required on Low--Low Steam Generator water level. The ability to...

  2. 78 FR 16876 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2013-03-19

    ... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... proposes to replace the VHS with an onsite diesel generator as the AAC power source providing this... power source (the VHS) with an additional onsite AAC power source (diesel generator). This equipment can...

  3. 77 FR 63343 - Biweekly Notice: Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-10-16

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... for an inoperable diesel generator (DG). A commensurate change is also proposed to extend the maximum... alternating current power source (i.e., a supplemental diesel generator) with the capability to power any E...

  4. 77 FR 73684 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-12-11

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... emergency diesel generator, and the stored lube oil inventory will also continue to require that a 7-day supply be available for each diesel generator. The changes are consistent with NRC-approved Technical...

  5. 77 FR 67679 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-11-13

    ... diesel generator surveillance requirements. Margin of safety is related to the ability of the fission... evaluated; or (3) involve a significant reduction in a margin of safety. The basis for this proposed... accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR Part 2...

  6. 78 FR 14126 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2013-03-04

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... of the document. The E-Filing system also distributes an email notice that provides access to the... Completion Time has no impact on the consequences of any design basis accident since the consequences of an...

  7. 76 FR 72984 - Revised Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2011-11-28

    ... NUCLEAR REGULATORY COMMISSION Revised Application for a License To Export High-Enriched Uranium The application for a license to export high-enriched Uranium has been revised as noted below. Notice... fabricate fuel France. Security Complex; October 18, Uranium (93.35%). uranium (174.0 elements in France...

  8. 76 FR 49462 - Newfound Hydroelectric Company, KTZ Hydro, LLC; Notice of Application for Transfer of License...

    Science.gov (United States)

    2011-08-10

    ... Hydroelectric Company, KTZ Hydro, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On July 25, 2011, Newfound Hydroelectric Company (transferor) and KTZ Hydro, LLC (transferee) filed an application for transfer of license for the Newfound Hydroelectric Project...

  9. 76 FR 59173 - Standard Format and Content of License Applications for Conventional Uranium Mills

    Science.gov (United States)

    2011-09-23

    ... NUCLEAR REGULATORY COMMISSION [NRC-2008-0302] Standard Format and Content of License Applications for Conventional Uranium Mills AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide..., ``Standard Format and Content of License Applications for Conventional Uranium Mills.'' DG- 3024 was a...

  10. 75 FR 70350 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2010-11-17

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [USCG-2010-0993] Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application AGENCY: Maritime Administration... announce they have received an application for the licensing of a natural gas deepwater port and the...

  11. SKB's safety case for a final repository license application

    International Nuclear Information System (INIS)

    Hedin, Allan; Andersson, Johan

    2014-01-01

    The safety assessment SR-Site is a main component in SKB's license application, submitted in March 2011, to construct and operate a final repository for spent nuclear fuel at Forsmark in the municipality of Oesthammar, Sweden. Its role in the application is to demonstrate long-term safety for a repository at Forsmark. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. The principal regulatory acceptance criterion, issued by the Swedish Radiation Safety Authority (SSM), requires that the annual risk of harmful effects after closure not exceed 10 -6 for a representative individual in the group exposed to the greatest risk. SSM's regulations also imply that the assessment time for a repository of this type is one million years after closure. The licence applied for is one in a stepwise series of permits, each requiring a safety report. The next step concerns a permit to start excavation of the repository and requires a preliminary safety assessment report (PSAR) covering both operational and post-closure safety. Later steps include permission to commence trial operation, to commence regular operation and to close the final repository. (authors)

  12. 75 FR 69080 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-10

    ... license as a Non-Vessel-Operating Common Carrier (NVO), and/or Ocean Freight Forwarder (OFF)--Ocean..., Building 14-A, Kenner, LA 70062, Officers: Gary J. Cheramie, President (Qualifying Individual), George...: License Transfer. Total Global Solutions, Inc. (NVO & OFF), 4290 Bells Ferry Road 224, Suite 106, Kennesaw...

  13. 78 FR 32650 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-31

    ... Change Abaco Logistics Corporation (OFF), 8051 NW 67th Street, Miami, FL 33166, Officers: Manuel T. Soto...: New NVO & OFF License Star Cluster Logistics (NVO & OFF), 4 Executive Circle, Suite 170, Irvine, CA... License Straight Forwarding, Inc. (NVO & OFF), 20974 Currier Road, City of Industry, CA 91789, Officer: Yi...

  14. Total System Performance Assessment - License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2003-12-08

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document.

  15. Structural Biology: Practical NMR Applications

    CERN Document Server

    Teng, Quincy

    2005-01-01

    This textbook begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

  16. 77 FR 21592 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2012-04-10

    ... Licensing of Non-Power Reactors: Format and Content,'' for the production of radioisotopes and NUREG-1537, Part 2, ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors... by searching on http://www.regulations.gov under Docket ID NRC-2011-0135. You may submit comments by...

  17. Licensing process for future applications of advanced-design nuclear reactors

    International Nuclear Information System (INIS)

    Miller, C.L.

    1990-01-01

    The existing 10CFR50 two-step licensing process in the Code of Federal Regulations can continue to be a viable licensing vehicle for future applications, at least for the near future. The US Nuclear Regulatory Commission (NRC) Commissioners and staff, the public, and the utilities (along with supporting architect/engineers and nuclear steam supply system vendors) have a vast body of experience and knowledge of the existing part 50 licensing process. All these participants are familiar with their respective roles in this process, and history shows this process to be a workable licensing vehicle. Nevertheless, the use of 10CFR52 should be encouraged for future applications. This proposed new rule is intended to achieve the early resolution of licensing issues, to reduce the complexity and uncertainty of the licensing process, and enhance the safety and reliability of nuclear power plants. Part 52's overall purpose is to improve reactor safety and streamline the licensing process by encouraging the use of standard reactor designs and by allowing the early resolution of site environmental and reactor safety issues. The public should be afforded an earlier entry into the licensing process as a result of design certification rulemaking process and combined construction permit/operating license hearings

  18. Biological applications of graphene oxide

    International Nuclear Information System (INIS)

    Gürel, Hikmet Hakan; Salmankurt, Bahadır

    2016-01-01

    Graphene as a 2D material has unique chemical and electronic properties. Because of its unique physical, chemical, and electronic properties, its interesting shape and size make it a promising nanomaterial in many biological applications. However, the lower water-solubility and the irreversible aggregation due to the strong π-π stacking hinder the wide application of graphene nanosheets in biomedical field. Thus, graphene oxide (GO), one derivative of graphene, has been used more frequently in the biological system owing to its relatively higher water solubility and biocompatibility. Recently, it has been demonstrated that nanomaterials with different functional groups on the surface can be used to bind the drug molecules with high affinity. GO has different functional groups such as H, OH and O on its surface; it can be a potential candidate as a drug carrier. The interactions of biomolecules and graphene like structures are long-ranged and very weak. Development of new techniques is very desirable for design of bioelectronics sensors and devices. In this work, we present first-principles spin polarized calculations within density functional theory to calculate effects of charging on DNA/RNA nucleobases on graphene oxide. It is shown that how modify structural and electronic properties of nucleobases on graphene oxide by applied charging.

  19. 78 FR 69852 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-21

    .... dba Freight Team dba iGlobal US (NVO & OFF), 15930 Valley Boulevard, City of Industry, CA 91744.... Amexlog Corporation dba Amex Logistics Corp (NVO & OFF), 1970 NW 70th Avenue, Miami, FL 33126. Officers... License. Canfleet Logistics Ltd. (NVO), 1408-700 West Pender Street, Vancouver, B.C. V6C 1G8. Officers...

  20. 76 FR 72409 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-23

    ... NVO Service. Pink City Logistics USA LLC (NVO & OFF), 7 Emily Road, Manalapan, NJ 07726; Officers... at (202) 523-5843 or by email at [email protected] . AE Eagle Logistics Inc. (NVO & OFF), 765 Route 83... License. Daybreak Logistics, Inc. (NVO & OFF), 2804 N. Cannon Blvd., Kannapolis, NC 28083; Officers...

  1. 77 FR 3773 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-01-25

    .... Hartwig Gdynia dba C. Hartwig Transport (NVO), 7, Derdowskiego Street, 81-369 Gdynia, Poland. Officers...: New OFF License. Cheryl G. Wilson dba JC Logistics (NVO & OFF), 28612 Redondo Beach Drive South, Des...: Add NVO Service. CR & J Logistics, Inc. dba Brightwater Shipping Services (NVO & OFF), 8401 Lake Worth...

  2. Use of limited information in a license application to construct a repository

    International Nuclear Information System (INIS)

    McGarry, J.M. III; Echols, F.S.

    1996-01-01

    The purpose of this paper is to provide a rationale for the proposition that the Department of Energy's (DOE's) submittal of a license application (LA) for the construction of a geologic repository to the Nuclear Regulatory Commission (NRC) may be, and arguably must be, based on statutorily-limited site characterization data and design information. The Nuclear Waste Policy Act of 1982 (NWPA), as amended, is the controlling statute for the disposal of spent nuclear fuel in a licensed geologic repository. Applicable NRC regulations for the licensing of such a repository are found for the most part in 10 C.F.R. Part 60

  3. Environmental Standard Review Plan for the review of license renewal applications for nuclear power plants

    International Nuclear Information System (INIS)

    O'Brien, J.; Kim, T.J.; Reynolds, S.

    1991-08-01

    The Environmental Standard Review Plan for the Review of License Applications for Nuclear Power Plants (ESRP-LR) is to be used by the NRC staff when performing environmental reviews of applications for the renewal of power reactor licenses. The use of the ESRP-LR provides a framework for the staff to determine whether or not environmental issues important to license renewal have been identified and the impacts evaluated and provides acceptance standards to help the reviewers comply with the National Environmental Policy Act

  4. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    International Nuclear Information System (INIS)

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  5. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  6. 77 FR 74841 - Alabama Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-12-18

    ... patrons who access the restaurant by boat. l. Locations of the Application: A copy of the application is... Company; Notice of Application for Amendment of License and Soliciting Comments, Motions To Intervene, and Protests Take notice that the following hydroelectric application has been filed with the Commission and is...

  7. Preparing to review the license application of the French geological disposal facility - Issues, challenges and perspectives

    International Nuclear Information System (INIS)

    Dandrieux, Geraldine

    2014-01-01

    This paper briefly describes the French context for GDR authorization, the French dedicated legislative framework (28 June 2006 Act on sustainable management of radioactive materials and waste), the challenges (regulatory issues, long-term project supervision, technical issues, procedural issues), and the preparing for the review of the DGR license application. A planning schedule is propose with Andra to submit license application for DGR in 2015

  8. Generic licensing issues applicable to Wolsong 3 and 4 licensing review

    International Nuclear Information System (INIS)

    Boyd, Frederick C.

    1994-01-01

    The Wolsong 3 and 4 nuclear power plants are of CANDU type which were designed according to the rules and regulations of the Atomic Energy Control Board (AECB) of Canada. In 1992 AECB staff issued a first formal report (to the AECB Board) on 'generic safety issues affecting power reactors'. This was followed by a second report in 1993. These reports dealt with safety issues associated with Canadian CANDU nuclear power plants that applied to all or several plants and were considered insufficiently resolved. In most cases the concern was lack of certainty in the related safety analyses. The AECB staff report of 1993 identified eight 'generic action items' and six 'long-term research issues', three of which AECB staff have indicated may be moved into the 'action' category. This report, prepared for the Korea Institute of Nuclear Safety (KINS), reviews the background of the AECB 'generic action items' and the three 'long-term research issues' noted above. It also reviews an additional topic - steam line failure outside of containment - which was included in the request from KINS. In all, twelve issues are covered. These background reviews are followed by a discussion of the relevance of each issue to the licensing review (for Construction Permit) of Wolsong 3 and 4 and recommended actions to be taken by KINS

  9. 78 FR 73566 - Standard Format and Content for a License Application for an Independent Spent Fuel Storage...

    Science.gov (United States)

    2013-12-06

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0264] Standard Format and Content for a License...), DG-3042, ``Standard Format and Content for a License Application for an Independent Spent Fuel..., Form, and Contents,'' specifies the information that must be in an application for a license to store...

  10. 77 FR 33243 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Science.gov (United States)

    2012-06-05

    ... expansion process, thermal expansion mismatch between the tube and tubesheet, and from the differential... NUCLEAR REGULATORY COMMISSION [NRC-2012-0125] Applications and Amendments to Facility Operating...

  11. Other best-estimate code and methodology applications in addition to licensing

    International Nuclear Information System (INIS)

    Tanarro, A.

    1999-01-01

    Along with their applications for licensing purposes, best-estimate thermalhydraulic codes allow for a wide scope of additional uses and applications, in which as realistic and realizable results as possible are necessary. Although many of these applications have been successfully developed nowadays, the use of best-estimate codes for applications other than those associated to licensing processes is not so well known among the nuclear community. This issue shows some of these applications, briefly describing their more significant and specific features. (Author)

  12. Preparing to Submit a License Application for Yucca Mountain

    International Nuclear Information System (INIS)

    W.J. Arthur; M.D. Voegele

    2005-01-01

    In 1982, the U.S. Congress passed the Nuclear Waste Policy Act, a Federal law that established U.S. policy for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Congress amended the Act in 1987, directing the Department of Energy to study only Yucca Mountain, Nevada as the site for a permanent geologic repository. As the law mandated, the Department evaluated Yucca Mountain to determine its suitability as the site for a permanent geologic repository. Decades of scientific studies demonstrated that Yucca Mountain would protect workers, the public, and the environment during the time that a repository would be operating and for tens of thousands of years after closure of the repository. A repository at this remote site would also: preserve the quality of the environment; allow the environmental cleanup of Cold War weapons facilities; provide the nation with additional protection from acts of terrorism; and support a sound energy policy. Throughout the scientific evaluation of Yucca Mountain, there has been no evidence to disqualify Yucca Mountain as a suitable site for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Upon completion of site characterization, the Secretary of Energy considered the results and concluded that a repository at Yucca Mountain would perform in a manner that protects public health and safety. The Secretary recommended the site to the President in February 2002; the President agreed and recommended to Congress that the site be approved. The Governor of Nevada submitted a notice of disapproval, and both houses of Congress acted to override the disapproval. In July 2002, the President's approval allowed the Department to begin the process of submittal of a license application for Yucca Mountain as the site for the nation's first repository for spent nuclear fuel and high-level radioactive waste. Yucca Mountain is located on federal land in Nye County in southern Nevada, an arid region

  13. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  14. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    International Nuclear Information System (INIS)

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  15. 77 FR 12830 - Pershing County Water Conservation District; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2012-03-02

    ... Water Conservation District; Notice of Intent To File License Application, Filing of Pre-Application.... Submitted by: Pershing County Water Conservation District (Pershing County). e. Name of Project: Humboldt... the Commission's regulations. h. Potential Applicant Contact: Bennie Hodges, Pershing County Water...

  16. Application of IC Card License for Road Transportation in Commercial Vehicles Supervision and Service

    Directory of Open Access Journals (Sweden)

    Li Weiwei

    2016-01-01

    Full Text Available IC card electronic license for road transport includes the IC card commercial vehicle’s certificate and IC card practitioner’s qualification certificate. In China, the IC card electronic license for road transport is the electronic ID card which must be carried by each commercial vehicles and practitioners. This paper briefly introduces the basic situation, data format and security keys architecture of IC card electronic license for road transportation of China. In order to strengthen the supervision and service of commercial vehicles, this paper puts forward the overall application framework of IC card electronic license for road transport. The application examples of IC card license in the supervision of passenger station, dangerous goods transport management, governance overload and logistics park and port area management are discussed. The practical application results show that the application of IC card electronic license for road transport is an important technical means to improve the supervision ability and service quality of the road transportation industry.

  17. 78 FR 54280 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2013-09-03

    ... the Commission's ``Agency Rules of Practice and Procedure'' in 10 CFR part 2. Interested person(s...-Filing system also distributes an email notice that provides access to the document to the NRC's Office... clarify language in the LSCS, Units 1 and 2, Technical Specifications (TS) applicable to the design...

  18. Biological applications of novel nonlinear optical microscopy

    International Nuclear Information System (INIS)

    Kajiyama, Shin'ichiro; Ozeki, Yasuyuki; Itoh, Kazuyoshi; Fukui, Kiichi

    2010-01-01

    Two types of newly developed nonlinear optical microscopes namely stimulated parametric emission (SPE) microscope and stimulated Raman scattering (SRS) microscope were presented together with their biological applications.

  19. Resolving the issues arisen during the development of License Renewal Application at PAKS NPP

    International Nuclear Information System (INIS)

    Ratkai, Sandor; Katona, Tamas Janos

    2012-01-01

    Operational license of the four VVER-440/213 units at Paks NPP, Hungary is limited to the design lifetime of 30 years. Extension by an additional 20 years of the original license is one of the main goals of the plant owner. In 2008 a programme for long-term operation (LTO) was developed and submitted to the Hungarian Atomic Energy Authority. The LTO Programme defines the activities for ensuring the extension of the operational lifetime and contains the justification of the safe LTO. The LTO Programme has to be implemented and comprehensive justification of the safe LTO has to be provided in the formal License Renewal Applications unit by unit. This work has been completed by the end of 2011, and the application has been submitted for approval for the Unit 1. The authority review and the approval of the License Renewal Application for Unit 1 should be finished before the expiration of the original design lifetime in 2012. In line with the regulations and supporting the License Renewal Application, a large number of engineering tasks have been performed. In this paper the entire project will be reported. The issues will be discussed, which have been arisen during the development of the application. The difficulties caused by the Hungarian technical and regulatory peculiarities will be presented. (author)

  20. 78 FR 13342 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-02-27

    .... Officers: Keith Phillips, Vice President (QI), Glenn Henderson, President. Application Type: New NVO & OFF.... Officers: Paul Pellitieri, President (QI), Virginia Pellitieri, Vice President. Application Type: New NVO...

  1. 77 FR 73054 - Application for a License To Export Radioactive Waste

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Radioactive Waste Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear..., October 25, 2012, XW020, radioactive 1178 pounds disposal by the 11006061. waste in the (approximately...

  2. 77 FR 14445 - Application for a License To Export Steel Forging

    Science.gov (United States)

    2012-03-09

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Steel Forging Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear... head steel February 7, 2012 forging. forging will be XR175 machined into the 11005983 finished vessel...

  3. 75 FR 15743 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-03-30

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the...-Enriched 160.0 kilograms To fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149...

  4. 75 FR 6223 - Application For a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-08

    ... NUCLEAR REGULATORY COMMISSION Application For a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the..., Uranium (93.35%). uranium (16.3 targets for December 28, 2009, XSNM3623, kilograms U-235). irradiation in...

  5. 77 FR 1956 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-01-12

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the.... Security Complex. Uranium uranium (9.3 targets at December 21, 2011 (93.35%). kilograms U- CERCA AREVA...

  6. 75 FR 7525 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-19

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the..., February 2, Uranium (93.35%). uranium (87.3 elements in 2010, February 2, 2010, kilograms U-235). France...

  7. 75 FR 71102 - White Mountain Hydroelectric Corp.; Notice of Application for Amendment of License, and...

    Science.gov (United States)

    2010-11-22

    ... Hydroelectric Corp.; Notice of Application for Amendment of License, and Soliciting Comments, Motions To Intervene, and Protests November 12, 2010. Take notice that the following hydroelectric application has been... Hydroelectric Corp. e. Name of Project: Apthorp Hydroelectric Project. f. Location: The project is located on...

  8. 76 FR 4417 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2011-01-25

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [USCG-2010-0993] Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application AGENCY: Maritime Administration... application describes an offshore natural gas deepwater port facility that would be located approximately 16.2...

  9. 77 FR 76483 - Ocean Transportation Intermediary License Applicants The Commission gives notice that the...

    Science.gov (United States)

    2012-12-28

    ... Transport Co., PAC International Logistics Company, & Book Express Network. Stealth Logistics LLC (NVO & OFF.... Application Type: QI Change. Efrinsa Global Logistics Inc. (NVO & OFF), 8441 NW 68th Street, Miami, FL 33166... (QI), Sheila E. Lawrence, President. Application Type: New OFF License. MMC Logistics, LLC (OFF), 2853...

  10. 75 FR 61474 - Juneau Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2010-10-05

    ... Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and....: 13563-001. c. Dated Filed: July 28, 2010. d. Submitted By: Juneau Hydropower, Inc. e. Name of Project... Commission's regulations. h. Potential Applicant Contact: Duff W. Mitchell, Juneau Hydropower, Inc., P.O. Box...

  11. 78 FR 28845 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-16

    ..., President, Application Type: QI Change Contract Logistics, LLC (NVO), 4911 North Portland Avenue, Suite 200..., Application Type: Add Trade Name Smart Lines Worldwide Feiliks Global Logistics Corporation (NVO), 176-20 S..., Director, Application Type: QI Change Intermodal Tank Transport (USA), Inc. (NVO), 2537 S. Gessner, Suite...

  12. Information to be submitted in support of licensing applications for nuclear power plants

    International Nuclear Information System (INIS)

    1979-01-01

    This Safety Guide was prepared as part of the Agency's programme, referred to as the NUSS programme, for establishing Codes of Practice and Safety Guides relating to nuclear power plants. It supplements the Agency's Safety Series No.50-C-G, entitled ''Governmental Organization for the Regulation of Nuclear Power Plants: A Code of Practice''. It is concerned with the content of documents which should be submitted to the regulatory body by the applicant/licensee in support of licensing applications, with a possible method of classifying these documents and with the scheduling of their submission to the regulatory body at each major stage of the licensing process

  13. Use of annotated outlines to prepare guidance for license applications for the MRS and MGDS

    International Nuclear Information System (INIS)

    Roberts, J.; Griffin, W.R.

    1992-01-01

    This paper reports that the Office of Civilian Radioactive Waste Management (OCRWM) has embarked on an aggressive program to develop guidance for preparation of the License Applications for the Mined Geological Disposal System (MGDS) and Monitored Retrievable Storage (MRS). The endeavor is a team effort that will utilize personnel and funding from the Office of Systems and Compliance at DOE Headquarters, the MRS Project (i.e., DOE Office of Storage and Transportation) and the Yucca Mountain Project (i.e., DOE Office of Geologic Disposal). The endeavor was initiated in the Spring of 1991. It will continue via an iterative process until License Applications are completed for the MRS and MGDS projects

  14. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z., E-mail: jonatasfmata@yahoo.com.br, E-mail: vasconv@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  15. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    International Nuclear Information System (INIS)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z.

    2015-01-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  16. 75 FR 32780 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-06-09

    .../Secretary, (Qualifying Individual), Bengt R. Anderson, President, Application Type: QI Change. Cargomar... Corp. (OFF & NVO), 6301 E. 10th Avenue, Hialeah, FL 33013, Officers: Marjorie E. Morales, Operation...

  17. 76 FR 19097 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-06

    ... Sachs, Partner/Logistics Manager (Qualifying Individual), Ali Ismailzada, Partner/CFO, Application Type... at (202) 523-5843 or by e-mail at [email protected] . Agility Logistics Corp. (OFF), 240 Commerce, Irvine... Avenue, Newark, NJ 07083, Officer: Hakeem K. Bisiolu, Member/Manager (Qualifying Individual), Application...

  18. 77 FR 23719 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-20

    ... Logistics, Inc. (NVO & OFF), 180 Champion Way, Northlake, IL 60164. Officers: David F. Gross, CEO (Qualifying Individual), Lance A. Lucibello, Vice President. Application Type: QI Change. CMA CGM Logistics... Fafoutis, General Manager (Qualifying Individual), Frank J. Baragona, Director. Application Type: New NVO...

  19. 75 FR 6398 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-02-09

    ... Forwarder Transportation Intermediary Applicants Best Way Logistics Corp., 901 SW. 98th Terrace, Pembroke..., Officers, Alessandro E. Bernardini, Sales Manager, (Qualifying Individual), Glenda Valdez, President... Intermediary Applicants (Cont'd): Vortex Worldwide Logistics Corp., 10125 NW. 116th Way, 10, Miami, FL 33178...

  20. 75 FR 66099 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-10-27

    ... Logistics, Inc. (NVO), 17890 Castleton Street, Suite 398, City of Industry, CA 91748, Officers: Jennifer X... (Qualifying Individual), Application Type: QI Change. Concert Group Logistics, Inc. (NVO & OFF), 1430 Branding... Individual), Daniel Para, CEO, Application Type: QI Change. De Well Logistics LLC dba De Well Logistics, dba...

  1. 75 FR 60124 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-29

    ... Individual), Sharlene Chesnes, EVP/COB/EVP/Secretary, Application Type: QI Change IAL Container Line (USA..., Vice President (Qualifying Individual), Arjun Menon, Director, Application Type: QI Change LTA Import & Export, Inc. (NVO & OFF), 14331 SW 120th Street, 203, Miami, FL 33186, Officers: Eric E. Diaz, Director...

  2. Microfluidic devices for biological applications

    CSIR Research Space (South Africa)

    Potgieter, S

    2010-01-01

    Full Text Available Microfluidics is a multi-disciplinary field that deals with the behaviour, control and manipulation of fluids constrained to sub-millilitre volumes. It is proving to be a useful tool for biological studies, affording advantages such as reduced cost...

  3. Licensing requirements for initial commissioning programs in Spain: Application to different PWR designs

    International Nuclear Information System (INIS)

    Munuera, A.; Conde, J.M.; Martinez, J.

    1991-01-01

    This paper describes the overall licensing process in Spain, focusing on the initial commissioning requirements. The significance of this part of the regulatory work is evident both from the licensing and the licensee's points of view. Licensing in Spain is ruled by different laws which determine the general requirements and fix the licensing frame. Being a nuclear technology importer country, the base of the regulatory work lies on the rules and regulations of the country of origin of the planet, with the addition of case specific requirements. The application of this methodology to plants designed in different countries produces licensing processes which are similar to the overall, but very different in its development. It also means a special technical effort on the part of the regulatory body to cope with the problems arising from the use of different technologies and safety standards. The start-up programs from fuel loading to full power of a Westinghouse plant (Vandellos 2) and a Siemens-KWU plant (Trillo 1) are compared from the technical point of view, enhancing the differences that can be relevant for the regulatory work. The difficulties arising from the application of both the German and US concepts are discussed. (orig.)

  4. Guide for the preparation of applications for licenses for the use of sealed sources in portable gauging devices

    International Nuclear Information System (INIS)

    1985-01-01

    The purpose of this regulatory guide is to provide assistance to applicants and licensees in preparing applications for new licenses, license amendments, and license renewals for the use of sealed sources in portable gauging devices. An example of a portable gauging device is a moisture-density gauge that contains a gamma-emitting sealed source, cesium-137, and a sealed neutron source, americium-242-beryllium

  5. 75 FR 52343 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-25

    ... Company, Inc. (NVO & OFF), 4529 Angeles Crest Highway, Suite 300, La Canada, CA 91011, Officers: Ernest V..., Application Type: QI Change. BestOcean Worldwide Logistics, Inc. (OFF & NVO), 1300 Valley Vista Drive, Suite...

  6. 76 FR 67188 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-10-31

    ... Liability Company, dba GlobalForwarding.com dba Forwardingservices.com dba Containerquote.com dba Global.../CEO/CFO, Application Type: QI Change. Unicorn Shipping, Inc. (NVO & OFF), 1225 W. 190th Street, Suite...

  7. 78 FR 30921 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-23

    .... (NVO & OFF), 2500 Wilcrest Drive, Suite 300, Houston, TX 77042, Officers: Myrian T. Morales, Vice..., FL 33178, Officer: Jose R. Gantus, President (QI), Application Type: QI Change XL Worldwide Corp...

  8. 76 FR 10593 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-25

    ... Individual), Steven L. Leturno, Director, Application Type: QI Change. Combined Freight System, Inc. (NVO...), 148-08 Guy R. Brewer Blvd., Jamaica, NY 11434, Officers: Wei Hu, Vice President, (Qualifying...

  9. 76 FR 71608 - Notice of Availability of Combined License Applications

    Science.gov (United States)

    2011-11-18

    ...://www.nrc.gov/reactors/new-reactors/col.html . FOR FURTHER INFORMATION CONTACT: Donald Habib, Office of..., email: Donald.Habib@nrc.gov . SUPPLEMENTARY INFORMATION: The following parties have filed applications...

  10. 76 FR 77021 - Notice of Availability of Combined License Applications

    Science.gov (United States)

    2011-12-09

    ...://www.nrc.gov/reactors/new-reactors/col.html . FOR FURTHER INFORMATION CONTACT: Donald Habib, Office of..., email: Donald.Habib@nrc.gov . SUPPLEMENTARY INFORMATION: The following parties have filed applications...

  11. 76 FR 72725 - Notice of Availability of Combined License Applications

    Science.gov (United States)

    2011-11-25

    ...://www.nrc.gov/reactors/new-reactors/col.html . FOR FURTHER INFORMATION CONTACT: Donald Habib, Office of..., email: Donald.Habib@nrc.gov . SUPPLEMENTARY INFORMATION: The following parties have filed applications...

  12. 78 FR 10173 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-02-13

    ... Road, Scituate, MA 02066, Officers: Stephen J. Zambo, Member (QI), Stephen A. Zambo, Member... 60007, Officers: Joshua H. Chau, President (QI), Bessie S. Chau, Secretary, Application Type: New NVO...

  13. 75 FR 28250 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-05-20

    ... Type: Add NVO Service and QI Change. Best Container Express, Inc. (NVO), 17238 S. Main Street, Gardena...). Peixin Li, President. Application Type: Add OFF Services. Project Rail, LLC dba Vectora Transportation...

  14. 76 FR 12962 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-03-09

    ... L. Li, President, Application Type: QI Change. EP-Team, Inc. dba EP-Team (NVO & OFF), 3700 Forums... Maritime Services USA (NVO), 425 West Main Street, Alhambra, CA 91801. Officers: Hans P. Hofmann, Assistant...

  15. 77 FR 32115 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-05-31

    ... Individual), Lar D. Westerberg, CEO, Application Type: Add NVO Service. Jo-Sak Shipping USA, Inc. (NVO & OFF... Service. Waterline International Logistics, Inc. (NVO & OFF), 24178 Alicia Parkway, Mission Viejo, CA...

  16. Microautoradiographic methods and their applications in biology

    International Nuclear Information System (INIS)

    Benes, L.

    1978-01-01

    A survey of microautoradiographic methods and of their application in biology is given. The current state of biological microautoradiography is shown, focusing on the efficiency of techniques and on special problems proceeding in autoradiographic investigations in biology. Four more or less independent fields of autoradiography are considered. In describing autoradiographic techniques two methodological tasks are emphasized: The further development of the labelling technique in all metabolic studies and of instrumentation and automation of autoradiograph evaluation. (author)

  17. Pesticide Applicator Profiling: Using Polycom[R] Distance Delivery for Continuing Education and Characterizing Florida's Licensed Applicators

    Science.gov (United States)

    Fishel, Fred; Langeland, Ken

    2011-01-01

    The University of Florida offers continuing education units (CEUs) via distance technology using Polycom[R] to meet requirements for applicators of pesticides to renew their licenses. A large statewide event conducted in 2010 also included a needs assessment of this group concerning CEUs. Results indicate that these applicators strongly prefer…

  18. 77 FR 34030 - BOST1 Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-06-08

    ... Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Date Filed: March 21, 2012. d. Submitted By: BOST1 Hydroelectric LLC (BOST1). e. Name of Project: Coon Rapids Dam Hydroelectric Project. f. Location: Mississippi River in Hennepin and Anoka counties...

  19. 77 FR 6552 - Mahoning Hydropower, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-02-08

    ... Hydropower, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and...: December 7, 2011. d. Submitted By: Mahoning Hydropower, LLC. e. Name of Project: Berlin Lake Hydroelectric... Hydropower, LLC, 11365 Normandy Lane, Chagrin Falls, OH 44023; (440) 804-6627; [email protected] i. FERC...

  20. 78 FR 45578 - Application For a License to Export Radioactive Waste

    Science.gov (United States)

    2013-07-29

    ... NUCLEAR REGULATORY COMMISSION Application For a License to Export Radioactive Waste Pursuant to 10..., 2013, radioactive waste authorized for disposal by the XW021, 11006101. as contaminated export will not original secondary waste exceed quantities generators, as resulting from imported in required or the...

  1. 77 FR 73056 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant... Complex. Uranium (93.2%). uranium-235 at CERCA AREVA Romans October 10, 2012 contained in 6.2 in France and to October 12, 2012 kilograms irradiate targets at XSNM3729 uranium. the BR-2 Research 11006053...

  2. 77 FR 73055 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Security Complex. Uranium uranium-235 at CERCA AREVA October 10, 2012 (93.35%). contained in Romans in France October 12, 2012 10.1 kilograms and to irradiate XSNM3730 uranium. targets at the HFR 11006054...

  3. 77 FR 51579 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-08-24

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Complex, July 30, 2012, August Uranium (93.35%). uranium-235 high-enriched 1, 2012, XSNM3726, 11006037. contained in 7.5 uranium in the kilograms uranium. form of broken metal to the Atomic Energy of Canada...

  4. 78 FR 33448 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2013-06-04

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Security Complex, May 13, Uranium (93.35%). uranium-235 at the National 2013, May 21, 2013, XSNM3745, contained in 7.5 Research Universal 11006098. kilograms reactor in Canada for uranium. ultimate use in...

  5. 18 CFR 131.20 - Application for approval of transfer of license.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Application for approval of transfer of license. 131.20 Section 131.20 Conservation of Power and Water Resources FEDERAL... a citizen of the United States of America. Subscribed and sworn to before me, a notary public of the...

  6. 75 FR 467 - Notice of Opportunity for Hearing, License Application Request of Powertech (USA) Inc. Dewey...

    Science.gov (United States)

    2010-01-05

    ... Hearing, License Application Request of Powertech (USA) Inc. Dewey-Burdock In Situ Uranium Recovery... Regulatory Commission (NRC) for the Dewey-Burdock In Situ Recovery Facility in Fall River and Custer Counties, South Dakota. The Dewey-Burdock facility would involve the recovery of uranium by in situ recovery (ISR...

  7. Shirley Basin Uranium Mill. Environmental report to accompany source material license application

    International Nuclear Information System (INIS)

    1975-12-01

    This document summarizes all of the environmental monitoring conducted by Utah. This Environmental Report consequently supplements and updates the information presented in the Source Material License application of August 18, 1970 and the Final Environmental Statement (FES) of December 1974. Water and air quality, liquid waste management, soil/vegetation monitoring, and reclamation are covered

  8. Standard format and content of license applications for plutonium processing and fuel fabrication plants

    International Nuclear Information System (INIS)

    1976-01-01

    The standard format suggested for use in applications for licenses to possess and use special nuclear materials in Pu processing and fuel fabrication plants is presented. It covers general description of the plant, summary safety assessment, site characteristics, principal design criteria, plant design, process systems, waste confinement and management, radiation protection, accident safety analysis, conduct of operations, operating controls and limits, and quality assurance

  9. 76 FR 63668 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2011-10-13

    ..., Research and Test Reactors Projects Branch, Division of Policy and Rulemaking, Office of Nuclear Reactor... NUCLEAR REGULATORY COMMISSION [NRC-2011-0135] Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes AGENCY: Nuclear Regulatory Commission. ACTION: Draft interim...

  10. NEP Nuclear Power Plant, Units 1 and 2. License application, general and financial information

    International Nuclear Information System (INIS)

    1976-01-01

    A license application is presented for 2 pressurized water reactors at a proposed location in Charlestown RI. Each reactor will have a net capacity of 1150 MW. Cooling water will be supplied by the Atlantic Ocean. NEP-1 is scheduled for operation in 1983 and NEP-2 in 1985

  11. 76 FR 71082 - Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License Application...

    Science.gov (United States)

    2011-11-16

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 40-9091; NRC-2011-0148] Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License Application; Notice of Intent To Prepare a... intent to prepare a supplemental environmental impact statement. SUMMARY: Strata Energy, Inc. (Strata...

  12. 78 FR 40519 - Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving...

    Science.gov (United States)

    2013-07-05

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-298; NRC-2013-0139] Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving Proposed No Significant Hazards..., issued to Nebraska Public Power District (the licensee), for operation of the Cooper Nuclear Station (CNS...

  13. 78 FR 64493 - Juneau Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA) and Draft...

    Science.gov (United States)

    2013-10-29

    ... Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA) and Draft Preliminary Draft... Hydropower, Inc. e. Name of Project: Sweetheart Lake Hydroelectric Project. f. Location: At the confluence of..., Business Manager, Juneau Hydropower, Inc., P.O. Box 22775, Juneau, AK 99802; 907-789-2775, email: duff...

  14. 76 FR 52994 - Application for a License To Export Heavy Water

    Science.gov (United States)

    2011-08-24

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Heavy Water Pursuant to 10 CFR... (liters). producing an active water). pharmaceutical ingredient known as CTP-499, which incorporates heavy water as the source of deuterium to achieve the hydrogen-deuterium exchange. November 30, 2010 December...

  15. 76 FR 53693 - Notice of Invitation To Participate; Coal Exploration License Application COC-74911, Colorado

    Science.gov (United States)

    2011-08-29

    ...] Notice of Invitation To Participate; Coal Exploration License Application COC-74911, Colorado AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Pursuant to the Mineral Leasing Act of 1920... America in lands located in Delta County, Colorado. DATES: This notice of invitation was published in the...

  16. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry.

  17. Biological applications of the Moessbauer effect

    International Nuclear Information System (INIS)

    Boulay, P.

    1968-12-01

    The applications of Moessbauer spectrometry in the fields of physics and chemistry have been increasing steadily since its discovery in 1958. Attempts have been made to find applications in biology. Two possibilities of investigation exist in this field: the study of mechanical or vibrational movements in certain animal organs, and the determination of the organic molecular structure in a biological context. An example is given of each of these possibilities. (author) [fr

  18. NPP long term operation in Spain - First application for license renewal

    International Nuclear Information System (INIS)

    Francia, L.; Gorrochategui, I.; Marcos, R.

    2007-01-01

    Full text: In the operation of the Spanish nuclear power plants (NPP), safety is always the prime consideration. Plant Life Management Programmes have been set up with the strategic objective to operate the NPPs as long as they are considered safe and reliable. The safety of each NPP is reviewed by the Spanish nuclear regulatory authority (CSN) under a continuous process. In addition, experience is gained from operating the plants and from exchanges with operators of similar units. Current Spanish regulatory framework for renewing NPP operating licenses requires performing a Periodic Safety Review (PSR) to be performed every 10 years and submitted when applying for a new renewal of the NPP operating license. A few years ago, CSN issued a document regarding the licensing requirements that nuclear power plants should meet in order to be granted with an operating license for long term operation (i.e, operation beyond the original plant design life, typically 40 years). Besides the traditional PSR requirements, specific requirements regarding to long term operation (LTO) include: - An Aging Management and Evaluation Program, including the identification and evaluation of Time Limited Aging Analysis (TLAA). - An updated Radiological Impact Study. - A review and assessment of regulation/standard applicability. Garona NPP (GE, BWR/3 design) operated by Spanish utility Nuclenor from 1971 has a current operating license up to 2009. A decision was made to apply for a new operating license, being Garona plant the first one in Spain to face with the new long term operation requirements. The paper will provide an overview of the methodology used in Spain to address and perform the required analyses to support the LTO application for the operating license renewal. In particular, focus will be paid on the project developed in Garona (2002-2006) whose result has been the first Spanish application for License Renewal for LTO. Also it will be reported the ongoing work necessary to

  19. 76 FR 25690 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-05-05

    .... Capital Logistics CHB Corp. (NVO & OFF), 6000 NW 97th Avenue, 9-10, Miami, FL 33178, Officers: Manuel G..., San Diego, CA 92126, Officers: Alex O. De Guzman, President, (Qualifying Individual), Abraham B. Lanuzga, Vice President, Application Type: Business Structure Change. Embarque Bandera Shipping, Inc. (NVO...

  20. 10 CFR 40.31 - Application for specific licenses.

    Science.gov (United States)

    2010-01-01

    ... response organizations expected to respond in case of an accident 60 days to comment on the licensee's... environment shall be filed at least 9 months prior to commencement of construction of the plant or facility in... case of renewal applications submitted before July 27, 1990, this submittal may follow the renewal...

  1. 76 FR 9015 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-16

    ... Global Logistics, LLC (NVO & OFF), 53 Perimeter Center East, Suite 450, Atlanta, GA 30346. Officer: Chad... Street, Doral, FL 33126. Officers: Juan P. Constain, General Manager (Qualifying Individual), Santiago...). Application Type: Add NVO Service. CoscoEx (CGL), Inc. dba Citic Global Logistics dba Chimerica Global...

  2. 76 FR 71034 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-16

    ... at (202) 523-5843 or by email at [email protected] . AAB Global Logistics, LLC (NVO & OFF), 201 E. Dundee...), Robert E. Cleary, Manager. Application Type: Name Change. Abco International Freight (USA) Inc. dba Abco Logistics (NVO), 9420 Telstar Avenue, 203, El Monte, CA 91731. Officers: Shermin Kong, Treasurer (Qualifying...

  3. 78 FR 63475 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-10-24

    ... dba Fachel Shipping & Logistics (NVO & OFF), 6331 Belair Road, Baltimore, MD 21206, Officers: Chinyere W. Osasuyi, Chief Executive Manager (QI), Famous I. Osasuyi, Chief Executive Member. Application... Change. Perimeter International dba Perimeter Logistics (NVO & OFF), 2700 Story Road, Suite 150, Irving...

  4. Barnwell Nuclear Fuel Plant. License application, amendment 10

    International Nuclear Information System (INIS)

    1975-01-01

    Amendment No. 10 provides the applicant's responses to questions raised by the AEC in letters dated November 6 and December 5, 1974. Amendment No. 3, dated February 1975, to the BNFP Separations Facility Final Safety Analysis Report (FSAR) is included. The amendment consists of revision pages for volumes 1 through 5 of the FSAR along with a deletion and insertion guide. (U.S.)

  5. 7 CFR 46.4 - Application for license.

    Science.gov (United States)

    2010-01-01

    ... principal office. A limited liability company shall also furnish a copy of its articles of organization and... the trustee must be furnished. If the applicant is a limited liability company and a member or holder of more than 10 percent of the ownership stake is a partnership, another limited liability company...

  6. 75 FR 42446 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-21

    ... Transportation Intermediary (OTI) pursuant to section 19 of the Shipping Act of 1984 as amended (46 U.S.C... Shipping Limited (NVO), 1000 Corporate Center Drive, Suite 320, Monterey Park, CA 91754. Officers: Joey Tam, President/CEO (Qualifying Individual), Yu C. Lee, Secretary/Treasurer. Application Type: Name Change. Ever...

  7. 75 FR 63476 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2010-10-15

    .... David A. Knott dba DAK Logistics Services (NVO), 1010 Bluejay Drive, Suisun City, CA 94585. Officer... Office of Transportation Intermediaries, Federal Maritime Commission, Washington, DC 20573. ACS Logistics.... Application Type: QI Change. Archer Logistics USA LLC (NVO), 6051 Kennedy Boulevard East, PhB, West New York...

  8. 78 FR 23252 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-18

    .... Logistics, Inc. dba BE Logistics dba Belogistics dba Core Logistics (NVO), 12911 Simms Avenue, Hawthorn, CA... (QI), Kevin L. Miller, Secretary, Application Type: QI Change Triple Eagle Logistics Inc. dba Triple Eagle Logistic Canada Inc. (NVO & OFF), 17890 Castleton Street, Suite 367, City of Industry, CA 91748...

  9. 77 FR 9657 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-02-17

    ..., Owner, Application Type: Add OFF Service. Cargo Tours International, Inc. dba CTI Global Logistics (NVO.... Deckwell Sky (USA) Inc. dba Monarch Container Line (NVO & OFF), 14343 E. Don Julian Road, City of Industry.... Logistics, Inc. (NVO & OFF), 3905 West Albany Street, McHenry, IL 60050, Officers: Arthur N. Nutig, Chief...

  10. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-27

    ... & OFF), 1515 Kona Drive, Compton, CA 90220, Officers: Won Rok (aka Steve) Choi, CFO (QI), Myeong H. Kim..., El Monte, CA 91731, Officers: Lynn H. Tran, Secretary (QI), Zheng Feng, CFO, Application Type: New.... 25th Street, Suite 107D, Miami, FL 33182, Officers: Sergio I. Lotero, President (QI), Stephen A. Blass...

  11. 78 FR 68444 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-14

    ... (America), Ltd. (NVO & OFF), 21061 S. Western Avenue, Suite 300, Torrance, CA 90501-1122, Officers: Mary M..., Officers: Kimberly A. Whisler Wagner, Member Manager (QI), Kara M. Norkus, Member Manager, Application Type..., Iselin, NJ 08830, Officers: Richard Kenyon, President (QI), Fernando Valenzuela, Global President...

  12. 77 FR 21559 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-10

    ... Individual). Luis Angel Rincon, Manager. Application Type: Business Structure Change and Add NVO Service. Dix.... Global Distribution & Logistics LLC (NVO & OFF), 7977 NW 21st Street, Miami, FL 33122. Officers: Jose L...: Edward J. Hathaway, Vice President-- Business Development (Qualifying Individual). Jeff Harvey, President...

  13. 78 FR 48435 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-08

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . A & J Cargo Logistics Inc... (QI), Application Type: Add Trade Name Arabia Cargo and OFF Service. CMX Global Logistics, LLC (NVO... Transport Co., Ltd. (NVO), 13101 Moore Street, Cerritos, CA 90703, Officers: Ki Hyeon Lee, CFO (QI), Seong...

  14. 78 FR 56229 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-12

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . ATS Logistics, LLC (NVO... Logistics Services, Inc. (NVO & OFF), One Cross Island Plaza, Suite 111, Rosedale, NY 11422, Officer: Jimmy..., Secretary, Application Type: QI Change World Link Transport, Inc. (NVO & OFF), 1220 Kona Drive, Compton, CA...

  15. 76 FR 31962 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-06-02

    .... International First Service USA, Inc. dba Global Wine Logistics, Inc. (NVO & OFF), 197 Route 18 South, Suite..., President, Application Type: Add NVO Service. Nano Express Corp. (NVO,) 5765 N. Lincoln Avenue, Suite 17... Zai Ocean Services dba Zai Container Line (NVO & OFF), 6324 NW 97th Avenue, Doral, FL 33178, Officer...

  16. 77 FR 35079 - License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC

    Science.gov (United States)

    2012-06-12

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-443; NRC-2010-0206] License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent to prepare supplement to draft [[Page 35080

  17. Spin labels. Applications in biology

    International Nuclear Information System (INIS)

    Frangopol, T.P.; Frangopol, M.; Ionescu, S.M.; Pop, I.V.; Benga, G.

    1980-11-01

    The main applications of spin labels in the study of biomembranes, enzymes, nucleic acids, in pharmacology, spin immunoassay are reviewed along with the fundamentals of the spin label method. 137 references. (author)

  18. Do US Medical Licensing Applications Treat Mental and Physical Illness Equivalently?

    Science.gov (United States)

    Gold, Katherine J; Shih, Elizabeth R; Goldman, Edward B; Schwenk, Thomas L

    2017-06-01

    State medical licensing boards are responsible for evaluating physician impairment. Given the stigma generated by mental health issues among physicians and in the medical training culture, we were interested in whether states asked about mental and physical health conditions differently and whether questions focused on current impairment. Two authors reviewed physician medical licensing applications for US physicians seeking first-time licensing in 2013 in the 50 states and the District of Columbia. Questions about physical and mental health, as well as substance abuse, were identified and coded as to whether or not they asked about diagnosis and/or treatment or limited the questions to conditions causing physician impairment. Forty-three (84%) states asked questions about mental health conditions, 43 (84%) about physical health conditions, and 47 (92%) about substance use. States were more likely to ask for history of treatment and prior hospitalization for mental health and substance use, compared with physical health disorders. Among states asking about mental health, just 23 (53%) limited all questions to disorders causing functional impairment and just 6 (14%) limited to current problems. While most state medical licensing boards ask about mental health conditions or treatment, only half limited queries to disorders causing impairment. Differences in how state licensing boards assess mental health raise important ethical and legal questions about assessing physician ability to practice and may discourage treatment for physicians who might otherwise benefit from appropriate care.

  19. Standard format and content for a license application to store spent fuel and high-level radioactive waste

    International Nuclear Information System (INIS)

    1989-09-01

    Subpart B, ''License Application, Form, and Contents,'' of 10 CFR Part 72, ''Licensing Requirements for the Independent Storage of Spent Nuclear Fuel and High-Level Radioactive Waste,'' specifies the information to be covered in an application for a license to store spent fuel in an independent spent fuel storage installation (ISFSI) or to store spent fuel and high-level radioactive waste in a monitored retrievable storage facility (MRS). However, Part 72 does not specify the format to be followed in the license application. This regulatory guide suggests a format acceptable to the NRC staff for submitting the information specified in Part 72 for license application to store spent fuel in an ISFSI or to store spent fuel and high-level radioactive waste in an MRS

  20. The regulatory review of construction license application and the supporting safety case

    International Nuclear Information System (INIS)

    Heinonen, Jussi

    2014-01-01

    Finland is one of the foremost countries in the world in developing the disposal of spent fuel. The construction license application for the Olkiluoto spent fuel disposal facility was submitted to the authorities at the end of 2012 and the facility is expected to start operation around 2020. This has been a long-term project with over 30 years of parallel development of the repository project and the regulatory approach to spent fuel management. In 1983 the government made a strategic decision on the objectives and target time schedule for the research, development and technical planning of nuclear waste management. While an export and international disposal solution was still the preferred option, this decision required the licensees without this possibility to prepare for disposal in Finland and it also gave the time line for the milestones on the way to an operating disposal facility by 2020. The licensing procedure for a disposal facility has several steps that are similar to all nuclear facilities in Finland and are defined in Nuclear Energy Act and Decree (1987, 1988). These licensing steps are: - Decision-in-principle is required for a nuclear facility having considerable general significance. This is essentially a political decision: the government decides if the construction project is in line with the overall good of society. The decision can be applied for one or more sites, the host municipality has a veto right and the parliament has the choice of ratifying or not ratifying the decision. - Construction license is granted by the government and authorises the construction of the disposal facility. The actual construction is regulated by STUK and includes several review and approval steps, hold points and viewpoints. - Operational license is granted by the government and authorises the operation of the facility for a certain period. The operational license is needed before nuclear waste can be disposed. The first step in the licensing process was reached

  1. Safety evaluation review of the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1991-08-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the belowground vault (BGV) alternative method of low-level radioactive waste disposal. In Volume 1 of NUREG-1375, the NRC staff provided the safety review results for an earth-mounded concrete bunker PLASAR. In the current report, the staff focused its review on the design, construction, and operational aspects of the BGV PLASAR. The staff developed review comments and questions using the Standard Review Plan (SRP), Rev. 1 (NUREG-1200) as the basis for evaluating the acceptability of the information provided in the BGV PLASAR. The detailed review comments provided in this report are intended to be useful guidance to facility developers and State regulators in addressing issues likely to be encountered in the review of a license application for a low-level-waste disposal facility. 44 refs

  2. Palo Verde Generating Station, Units 4 and 5. License application, general information

    International Nuclear Information System (INIS)

    1978-01-01

    A license application for two more Palo Verde reactors, Units 4 and 5, is presented. The two PWR reactors have a nominal net generating power each of 1,270 MW(e). Containments are steel-lined prestressed cylindrical structures with hemispherical domes. The reactors are replicas of Palo Verde 1, 2 and 3 (see DOCKETS 50528, 50529 and 50530) using the standard Combustion Engineering System 80 (see DOCKET-STN-50470)

  3. Functionalized Nanodiamonds for Biological and Medical Applications.

    Science.gov (United States)

    Lai, Lin; Barnard, Amanda S

    2015-02-01

    Nanodiamond is a promising material for biological and medical applications, owning to its relatively inexpensive and large-scale synthesis, unique structure, and superior optical properties. However, most biomedical applications, such as drug delivery and bio-imaging, are dependent upon the precise control of the surfaces, and can be significantly affected by the type, distribution and stability of chemical funtionalisations of the nanodiamond surface. In this paper, recent studies on nanodiamonds and their biomedical applications by conjugating with different chemicals are reviewed, while highlighting the critical importance of surface chemical states for various applications.

  4. Synthetic biology platform technologies for antimicrobial applications.

    Science.gov (United States)

    Braff, Dana; Shis, David; Collins, James J

    2016-10-01

    The growing prevalence of antibiotic resistance calls for new approaches in the development of antimicrobial therapeutics. Likewise, improved diagnostic measures are essential in guiding the application of targeted therapies and preventing the evolution of therapeutic resistance. Discovery platforms are also needed to form new treatment strategies and identify novel antimicrobial agents. By applying engineering principles to molecular biology, synthetic biologists have developed platforms that improve upon, supplement, and will perhaps supplant traditional broad-spectrum antibiotics. Efforts in engineering bacteriophages and synthetic probiotics demonstrate targeted antimicrobial approaches that can be fine-tuned using synthetic biology-derived principles. Further, the development of paper-based, cell-free expression systems holds promise in promoting the clinical translation of molecular biology tools for diagnostic purposes. In this review, we highlight emerging synthetic biology platform technologies that are geared toward the generation of new antimicrobial therapies, diagnostics, and discovery channels. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Applications of Microfluidics in Quantitative Biology.

    Science.gov (United States)

    Bai, Yang; Gao, Meng; Wen, Lingling; He, Caiyun; Chen, Yuan; Liu, Chenli; Fu, Xiongfei; Huang, Shuqiang

    2018-05-01

    Quantitative biology is dedicated to taking advantage of quantitative reasoning and advanced engineering technologies to make biology more predictable. Microfluidics, as an emerging technique, provides new approaches to precisely control fluidic conditions on small scales and collect data in high-throughput and quantitative manners. In this review, the authors present the relevant applications of microfluidics to quantitative biology based on two major categories (channel-based microfluidics and droplet-based microfluidics), and their typical features. We also envision some other microfluidic techniques that may not be employed in quantitative biology right now, but have great potential in the near future. © 2017 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. Biotechnology Journal Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  6. Strategic Basis for License Application Planning for a Potential Yucca Mountain Repository

    International Nuclear Information System (INIS)

    Newberry, C. M.; Brocoum, S. J.; Gamble, R. P.; Murray, R. C.; Cline, M.

    2002-01-01

    If Yucca Mountain, Nevada is designated as the site for development of a geologic repository for disposal of spent nuclear fuel and high-level radioactive waste, the Department of Energy (DOE) must obtain Nuclear Regulatory Commission (NRC) approval first for repository construction, then for an operating license, and, eventually, for repository closure and decommissioning. The licensing criteria defined in Code of Federal Regulations, Title 10, Part 63 (10 CFR Part 63) establish the basis for these NRC decisions. Submittal of a license application (LA) to the NRC for authorization to construct a repository at the Yucca Mountain site is, at this point, only a potential future action by the DOE. The policy process defined in the Nuclear Waste Policy Act (NWPA), as amended, for recommendation and designation of Yucca Mountain as a repository site makes it difficult to predict whether or when the site might be designated. The DOE may only submit a LA to the NRC if the site designation takes effect. In spite of this uncertainty, the DOE must take prudent and appropriate action now, and over the next several years, to prepare for development and timely submittal of a LA. This is particularly true given the need for the DOE to develop, load, and certify the operation of its electronic information system to provide access to its relevant records as part of the licensing support network (LSN) in compliance with NRC requirements six months prior to LA submittal. The DOE must also develop a LA, which is a substantially different document from those developed to support a Site Recommendation (SR) decision. The LA must satisfy NRC licensing criteria and content requirements, and address the acceptance criteria defined by the NRC in its forthcoming Yucca Mountain Review Plan (YMRP). The content of the LA must be adequate to facilitate NRC acceptance and docketing for review, and the LA and its supporting documents must provide the documented basis for the NR C findings required

  7. [Applications of synthetic biology in materials science].

    Science.gov (United States)

    Zhao, Tianxin; Zhong, Chao

    2017-03-25

    Materials are the basis for human being survival and social development. To keep abreast with the increasing needs from all aspects of human society, there are huge needs in the development of advanced materials as well as high-efficiency but low-cost manufacturing strategies that are both sustainable and tunable. Synthetic biology, a new engineering principle taking gene regulation and engineering design as the core, greatly promotes the development of life sciences. This discipline has also contributed to the development of material sciences and will continuously bring new ideas to future new material design. In this paper, we review recent advances in applications of synthetic biology in material sciences, with the focus on how synthetic biology could enable synthesis of new polymeric biomaterials and inorganic materials, phage display and directed evolution of proteins relevant to materials development, living functional materials, engineered bacteria-regulated artificial photosynthesis system as well as applications of gene circuits for material sciences.

  8. Mammalian synthetic biology: emerging medical applications.

    Science.gov (United States)

    Kis, Zoltán; Pereira, Hugo Sant'Ana; Homma, Takayuki; Pedrigi, Ryan M; Krams, Rob

    2015-05-06

    In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON-OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug discovery, drug delivery, receptor-activating gene circuits and mammalian biomanufacturing processes. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  9. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    Energy Technology Data Exchange (ETDEWEB)

    Silverman, D.J.; Bauser, M.A. [Morgan, Lewis and Bockius, Washington, DC (United States); Baird, R.D. [Rogers and Associates Engineering Corp., Salt Lake City, UT (United States)

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application.

  10. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    International Nuclear Information System (INIS)

    Silverman, D.J.; Bauser, M.A.; Baird, R.D.

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  11. Shaping Biological Knowledge: Applications in Proteomics

    Directory of Open Access Journals (Sweden)

    R. Appel

    2006-04-01

    Full Text Available The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa and a hypothesis-driven (focus on whole bacterial proteomes approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  12. Shaping biological knowledge: applications in proteomics.

    Science.gov (United States)

    Lisacek, F; Chichester, C; Gonnet, P; Jaillet, O; Kappus, S; Nikitin, F; Roland, P; Rossier, G; Truong, L; Appel, R

    2004-01-01

    The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa) and a hypothesis-driven (focus on whole bacterial proteomes) approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  13. Development, assessment, licensing, and application of RELAP5YA at Yankee Atomic Electric Company

    International Nuclear Information System (INIS)

    Husain, A.

    1984-01-01

    Since 1975, Yankee Atomic Electric Company (YAEC) has been licensed to perform LOCA analyses (large and small breaks) for PWRs. The methods are based upon the WREM package, comprised of RELAP4-MOD 3, RELAP4-FLOOD, and TOODEE-2EM. Significant efforts were expended to compare WREM models against Appendix K criteria, and to incorporate changes for compliance with the criteria and for improved representation of LOCA phenomena. /SUP 2,3,4/ This internalized capability has been used extensively for licensing the Yankee and Maine Yankee plants, and for timely resolution of LOCA issues which frequently arose. The value of this internalized analysis capability was well recognized by the Yankee management. In 1979, Yankee embarked upon another LOCA Methods Development Program. One objective was to remove extra conservatisms inherent in older codes to provide additional operational flexibility for our plants. Also, we needed a code which could be used in a production mode to provide realistic response for off-normal conditions to be used in operator training and emergency guideline assessment. This program resulted in the development of RELAP5YA. The development, assessment, licensing, and application of RELAP5YA at YAEC is briefly described in this paper

  14. Application of Quantum Dots in Biological Imaging

    Directory of Open Access Journals (Sweden)

    Shan Jin

    2011-01-01

    Full Text Available Quantum dots (QDs are a group of semiconducting nanomaterials with unique optical and electronic properties. They have distinct advantages over traditional fluorescent organic dyes in chemical and biological studies in terms of tunable emission spectra, signal brightness, photostability, and so forth. Currently, the major type of QDs is the heavy metal-containing II-IV, IV-VI, or III-V QDs. Silicon QDs and conjugated polymer dots have also been developed in order to lower the potential toxicity of the fluorescent probes for biological applications. Aqueous solubility is the common problem for all types of QDs when they are employed in the biological researches, such as in vitro and in vivo imaging. To circumvent this problem, ligand exchange and polymer coating are proven to be effective, besides synthesizing QDs in aqueous solutions directly. However, toxicity is another big concern especially for in vivo studies. Ligand protection and core/shell structure can partly solve this problem. With the rapid development of QDs research, new elements and new morphologies have been introduced to this area to fabricate more safe and efficient QDs for biological applications.

  15. Molecular biology applications to infectious diseases diagnostic

    International Nuclear Information System (INIS)

    2001-01-01

    This project goes directed to the applications of the techniques of molecular biology in hepatitis virus.A great advance of these techniques it allows its application to the diagnose molecular and it becomes indispensable to have these fundamental tools in the field of the Health Public for the detection precocious, pursuit of the treatment, the one predicts and the evolution of the patient hepatitis bearing virus technical.Use of molecular biology to increase the handling and the control of the patients with hepatitis B and C and to detect an adult numbers of positive cases by means of the training and integration of all the countries participating.Implement the technique of PCR to identify the virus of the hepatitis B and C,implement quantification methods and genotipification for these virus

  16. Biocompatible Quantum Dots for Biological Applications

    Science.gov (United States)

    Rosenthal, Sandra J.; Chang, Jerry C.; Kovtun, Oleg; McBride, James R.; Tomlinson, Ian D.

    2011-01-01

    Semiconductor quantum dots are quickly becoming a critical diagnostic tool for discerning cellular function at the molecular level. Their high brightness, long-lasting, sizetunable, and narrow luminescence set them apart from conventional fluorescence dyes. Quantum dots are being developed for a variety of biologically oriented applications, including fluorescent assays for drug discovery, disease detection, single protein tracking, and intracellular reporting. This review introduces the science behind quantum dots and describes how they are made biologically compatible. Several applications are also included, illustrating strategies toward target specificity, and are followed by a discussion on the limitations of quantum dot approaches. The article is concluded with a look at the future direction of quantum dots. PMID:21276935

  17. Application of nanotechnology in biology and promising application in radiobiology

    International Nuclear Information System (INIS)

    Zhao Sanhu; Ni Jin; Cai Jianming

    2011-01-01

    As one of the 21-Century high and new technologies, nanotechnology (NT) has been widely applied in all aspects of biology. From now on, it has been used for detecting substance, carrying drug, antibacterial and tumour therapy by its photometric characteristics, mechanics characteristics, thermal property and other characteristics. Because of the unique advantages of nanoparticles, nanotechnology has great potential in radioprotection. In this article, we introduced the application of nanotechnology in modern biology and the primal problems. Meantime, we explain the prospect of its application in radioprotection. (authors)

  18. Model tracking system for low-level radioactive waste disposal facilities: License application interrogatories and responses

    Energy Technology Data Exchange (ETDEWEB)

    Benbennick, M.E.; Broton, M.S.; Fuoto, J.S.; Novgrod, R.L.

    1994-08-01

    This report describes a model tracking system for a low-level radioactive waste (LLW) disposal facility license application. In particular, the model tracks interrogatories (questions, requests for information, comments) and responses. A set of requirements and desired features for the model tracking system was developed, including required structure and computer screens. Nine tracking systems were then reviewed against the model system requirements and only two were found to meet all requirements. Using Kepner-Tregoe decision analysis, a model tracking system was selected.

  19. Model tracking system for low-level radioactive waste disposal facilities: License application interrogatories and responses

    International Nuclear Information System (INIS)

    Benbennick, M.E.; Broton, M.S.; Fuoto, J.S.; Novgrod, R.L.

    1994-08-01

    This report describes a model tracking system for a low-level radioactive waste (LLW) disposal facility license application. In particular, the model tracks interrogatories (questions, requests for information, comments) and responses. A set of requirements and desired features for the model tracking system was developed, including required structure and computer screens. Nine tracking systems were then reviewed against the model system requirements and only two were found to meet all requirements. Using Kepner-Tregoe decision analysis, a model tracking system was selected

  20. Application of ASP Technology to Realize the Online Administrative License of the earthquake in Hunan Province

    Science.gov (United States)

    Tang, Hongliang; Kang, Chengxu; Tian, Youping

    2018-01-01

    Realizing the online handling of administrative approval of earthquakes is an important measure to improve work efficiency and facilitate people’s convenience. Based on the analysis of the characteristics and processes of the administrative licensing in the earthquake industry, this paper proposes an online processing model based on ASP technology and an online processing system based on B/S architecture. This paper presents the design and implementation methods. The application of the system shows that the system is simple in design and full in function, and can be used on mobile platforms such as computers and mobile phones, and has good practicability and forward-lookingness.

  1. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-04-18

    ... Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 20, 2012. d. Submitted By: Lock+ Hydro Friends Fund XXX, LLC. e. Name of Project... Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XXX, c/o Hydro Green Energy, LLC, 900...

  2. 47 CFR 25.137 - Application requirements for earth stations operating with non-U.S. licensed space stations.

    Science.gov (United States)

    2010-10-01

    ... space stations. (a) Earth station applicants or entities filing a “letter of intent” or “Petition for... Union. (d) Earth station applicants requesting authority to operate with a non-U.S.-licensed space... 47 Telecommunication 2 2010-10-01 2010-10-01 false Application requirements for earth stations...

  3. Carbon nanotubes for biological and biomedical applications

    International Nuclear Information System (INIS)

    Yang Wenrong; Thordarson, Pall; Gooding, J Justin; Ringer, Simon P; Braet, Filip

    2007-01-01

    Ever since the discovery of carbon nanotubes, researchers have been exploring their potential in biological and biomedical applications. The recent expansion and availability of chemical modification and bio-functionalization methods have made it possible to generate a new class of bioactive carbon nanotubes which are conjugated with proteins, carbohydrates, or nucleic acids. The modification of a carbon nanotube on a molecular level using biological molecules is essentially an example of the 'bottom-up' fabrication principle of bionanotechnology. The availability of these biomodified carbon nanotube constructs opens up an entire new and exciting research direction in the field of chemical biology, finally aiming to target and to alter the cell's behaviour at the subcellular or molecular level. This review covers the latest advances of bio-functionalized carbon nanotubes with an emphasis on the development of functional biological nano-interfaces. Topics that are discussed herewith include methods for biomodification of carbon nanotubes, the development of hybrid systems of carbon nanotubes and biomolecules for bioelectronics, and carbon nanotubes as transporters for a specific delivery of peptides and/or genetic material to cells. All of these current research topics aim at translating these biotechnology modified nanotubes into potential novel therapeutic approaches. (topical review)

  4. Review process for low-level radioactive waste disposal license application under Low-Level Radioactive Waste Policy Amendments Act

    International Nuclear Information System (INIS)

    Pittiglio, C.L. Jr.

    1987-08-01

    This document estimates the level of effort and expertise that is needed to review a license application within the required time. It is intended to be used by the NRC staff as well as States and interested parties to provide a better understanding of what the NRC envisions will be involved in licensing a low-level radioactive waste disposal facility. 5 refs., 3 figs., 1 tab

  5. Marine Carotenoids: Biological Functions and Commercial Applications

    Science.gov (United States)

    Vílchez, Carlos; Forján, Eduardo; Cuaresma, María; Bédmar, Francisco; Garbayo, Inés; Vega, José M.

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functions of carotenoids relevant for life on earth. Biological properties of carotenoids allow for a wide range of commercial applications. Indeed, recent interest in the carotenoids has been mainly for their nutraceutical properties. A large number of scientific studies have confirmed the benefits of carotenoids to health and their use for this purpose is growing rapidly. In addition, carotenoids have traditionally been used in food and animal feed for their color properties. Carotenoids are also known to improve consumer perception of quality; an example is the addition of carotenoids to fish feed to impart color to farmed salmon. PMID:21556162

  6. Application of activation techniques to biological analysis

    International Nuclear Information System (INIS)

    Bowen, H.J.M.

    1981-01-01

    Applications of activation analysis in the biological sciences are reviewed for the period of 1970 to 1979. The stages and characteristics of activation analysis are described, and its advantages and disadvantages enumerated. Most applications involve activation by thermal neutrons followed by either radiochemical or instrumental determination. Relatively little use has been made of activation by fast neutrons, photons, or charged particles. In vivo analyses are included, but those based on prompt gamma or x-ray emission are not. Major applications include studies of reference materials, and the elemental analysis of plants, marine biota, animal and human tissues, diets, and excreta. Relatively little use of it has been made in biochemistry, microbiology, and entomology, but it has become important in toxicology and environmental science. The elements most often determined are Ag, As, Au, Br, Ca, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, I, K, Mn, Mo, Na, Rb, Sb, Sc, Se, and Zn, while few or no determinations of B, Be, Bi, Ga, Gd, Ge, H, In, Ir, Li, Nd, Os, Pd, Pr, Pt, Re, Rh, Ru, Te, Tl, or Y have been made in biological materials

  7. Preparing as an organization to review a construction license application for a DGR for HLW and SF in the USA

    International Nuclear Information System (INIS)

    Hill, Brittain

    2014-01-01

    Although formally opposed by the State of Nevada, the Yucca Mountain site (Nevada) recommendation was approved by the U.S. Congress and the President, which authorized DOE to prepare and submit a license application for a deep geologic repository for the nation's spent nuclear fuel and high-level waste. In June of 2008, DOE submitted this application to the U.S. Nuclear Regulatory Commission (NRC) for its review and formal adjudication of contested issues during a 3-4 year period. Although subsequent actions by the Administration and Congress have changed the direction for geologic disposal in the U.S., the NRC staff was able to conduct a thorough technical review of the DOE license application and issue technical evaluation reports before the review and hearings were suspended in September 2011. This paper provides the author's perspective on how the NRC prepared for, and conducted, this first-of-a-kind licensing review: planning framework, key preparations for staff and for processes, events after the receipt of a license application, retrospective on staff preparations and on processes. By the end of September 2011, the NRC staff had issued three Technical Evaluation Reports using a risk-informed, performance-based approach to review the DOE license application for this deep geologic repository at Yucca Mountain

  8. Cyber integrated MEMS microhand for biological applications

    Science.gov (United States)

    Weissman, Adam; Frazier, Athena; Pepen, Michael; Lu, Yen-Wen; Yang, Shanchieh Jay

    2009-05-01

    Anthropomorphous robotic hands at microscales have been developed to receive information and perform tasks for biological applications. To emulate a human hand's dexterity, the microhand requires a master-slave interface with a wearable controller, force sensors, and perception displays for tele-manipulation. Recognizing the constraints and complexity imposed in developing feedback interface during miniaturization, this project address the need by creating an integrated cyber environment incorporating sensors with a microhand, haptic/visual display, and object model, to emulates human hands' psychophysical perception at microscale.

  9. AIE Polymers: Synthesis, Properties, and Biological Applications.

    Science.gov (United States)

    Zhan, Ruoyu; Pan, Yutong; Manghnani, Purnima Naresh; Liu, Bin

    2017-05-01

    Aggregation-caused quenching (ACQ) is a general phenomenon that is faced by traditional fluorescent polymers. Aggregation-induced emission (AIE) is exactly opposite to ACQ. AIE molecules are almost nonemissive in their molecularly dissolved state, but they can be induced to show high fluorescence in the aggregated or solid state. Incorporation of AIE phenomenon into polymer design has yielded various polymers with AIE characteristics. In this review, the recent progress of AIE polymers for biological applications is summarized. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. PIXE and its applications to biological samples

    International Nuclear Information System (INIS)

    Aldape, F.; Flores, M.J.

    1996-01-01

    Throughout this century, industrialized society has seriously affected the ecology by introducing huge amounts of pollutants into the atmosphere as well as marine and soil environments. On the other hand, it is known that these pollutants, in excess of certain levels of concentration, not only put at risk the life of living beings but may also cause the extinction of some species. It is therefore of basic importance to substantially increase quantitative determinations of trace element concentrations in biological specimens in order to assess the effects of pollutants. It is in this field that PIXE plays a key role in these studies, where its unique analytical properties are decisive. Moreover, since the importance of these research has been recognized in many countries, many scientists have been encouraged to continue or initiate new research programmes aimed to solve the worldwide pollution problem. This document presents an overview of those papers reporting the application of PIXE analysis to biological samples during this last decade of the 20th century and recounts the number of PIXE laboratories dedicating their efforts to find the clues of the biological effects of the presence of pollutants introduced in living beings. Sample preparation methods, different kinds of samples under study and the use of complementary analytical techniques are also illustrated. (author). 108 refs

  11. 18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL POWER ACT PROCEDURES RELATING TO TAKEOVER AND RELICENSING OF LICENSED PROJECTS Applications for... redistribution of power flows on line loading (with respect to applicable thermal, voltage, or stability limits... governmental agencies and subdivisions likely to be interested in or affected by the proposed expansion. (11...

  12. 75 FR 3261 - Powertech (USA) Inc.; Dewey-Burdock Project; New Source Material License Application; Notice of...

    Science.gov (United States)

    2010-01-20

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 40-9075; NRC-2009-0575] Powertech (USA) Inc.; Dewey... review process related to the Dewey- Burdock Uranium Project application, please contact the NRC... documents associated with the Dewey-Burdock Uranium Project, including the license application, are...

  13. 76 FR 40905 - Turnagain Arm Tidal Electric Energy Project; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2011-07-12

    ... Tidal Electric Energy Project; Notice of Intent To File License Application, Filing of Pre-Application....: 13509-001. c. Dated Filed: May 11, 2011. d. Submitted By: Turnagain Arm Tidal Energy Corporation. e. Name of Project: Turnagain Arm Tidal Electric Energy Project. f. Location: Of the Upper Cook Inlet off...

  14. 77 FR 58370 - Pennamaquan Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-09-20

    ... Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre-Application Document (PAD... Filed: July 19, 2012. d. Submitted By: Pennamaquan Tidal Power LLC (Pennamaquan Power). e. Name of Project: Pennamaquan Tidal Power Plant Project. f. Location: On the Pennamaquan River at the entrance to...

  15. 76 FR 81992 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2011-12-29

    ... License Application for Bell Bend Nuclear Power Plant; Exemption 1.0 Background PPL Bell Bend, LLC... for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend Nuclear Power Plant (BBNPP... based upon the U.S. EPR reference COL (RCOL) application for UniStar's Calvert Cliffs Nuclear Power...

  16. 75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2010-08-20

    ... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

  17. Gibbs and Hill Standard Safety Analysis Report, GIBBSSAR. License application, volume 1: chapters 1--3 (section 7)

    International Nuclear Information System (INIS)

    1977-01-01

    License application for the GIBBSSAR Standard Plant is presented. The reactor used with the GIBBSSAR balance-of-plant system is the Westinghouse 3800 MW(t) PWR. This portion of the application includes a general plant description; site characteristics; and design of structures, components, equipment and systems

  18. Safety evaluation status report for the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1989-07-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the earth-mounded concrete bunker (EMCB) alternative method of low-level radioactive waste disposal. The NRC reviewers relied extensively on the Standard Review Plan (SRP), Rev.1 (NUREG-1200), to evaluate the acceptability of the information provided in the EMCB PLASAR. The NRC staff selected certain review areas in the PLASAR for development of safety evaluation report input to provide examples of safety assessments that are necessary as part of a licensing review. Because of the fictitious nature of the assumed disposal site, and the decision to limit the review to essentially first-round review status, the NRC staff report is labeled a ''Safety Evaluation Status Report'' (SESR). Appendix A comprises the NRC review comments and questions on the information that DOE submitted in the PLASAR. The NRC concentrated its review on the design and operations-related portions of the EMCB PLASAR

  19. Screening Analysis of Criticality Features, Events, and Processes for License Application

    International Nuclear Information System (INIS)

    J.A. McClure

    2004-01-01

    This report documents the screening analysis of postclosure criticality features, events, and processes. It addresses the probability of criticality events resulting from degradation processes as well as disruptive events (i.e., seismic, rock fall, and igneous). Probability evaluations are performed utilizing the configuration generator described in ''Configuration Generator Model'', a component of the methodology from ''Disposal Criticality Analysis Methodology Topical Report''. The total probability per package of criticality is compared against the regulatory probability criterion for inclusion of events established in 10 CFR 63.114(d) (consider only events that have at least one chance in 10,000 of occurring over 10,000 years). The total probability of criticality accounts for the evaluation of identified potential critical configurations of all baselined commercial and U.S. Department of Energy spent nuclear fuel waste form and waste package combinations, both internal and external to the waste packages. This criticality screening analysis utilizes available information for the 21-Pressurized Water Reactor Absorber Plate, 12-Pressurized Water Reactor Absorber Plate, 44-Boiling Water Reactor Absorber Plate, 24-Boiling Water Reactor Absorber Plate, and the 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Short waste package types. Where defensible, assumptions have been made for the evaluation of the following waste package types in order to perform a complete criticality screening analysis: 21-Pressurized Water Reactor Control Rod, 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Long, and 2-Multi-Canister Overpack/2-Defense High-Level Radioactive Waste package types. The inputs used to establish probabilities for this analysis report are based on information and data generated for the Total System Performance Assessment for the License Application, where available. This analysis report determines whether criticality is to be

  20. [Radiation protection in medical research : Licensing requirement for the use of radiation and advice for the application procedure].

    Science.gov (United States)

    Minkov, V; Klammer, H; Brix, G

    2017-07-01

    In Germany, persons who are to be exposed to radiation for medical research purposes are protected by a licensing requirement. However, there are considerable uncertainties on the part of the applicants as to whether licensing by the competent Federal Office for Radiation Protection is necessary, and regarding the choice of application procedure. The article provides explanatory notes and practical assistance for applicants and an outlook on the forthcoming new regulations concerning the law on radiation protection of persons in the field of medical research. Questions and typical mistakes in the application process were identified and evaluated. The qualified physicians involved in a study are responsible for deciding whether a license is required for the intended application of radiation. The decision can be guided by answering the key question whether the study participants would undergo the same exposures regarding type and extent if they had not taken part in the study. When physicians are still unsure about their decision, they can seek the advisory service provided by the professional medical societies. Certain groups of people are particularly protected through the prohibition or restriction of radiation exposure. A simplified licensing procedure is used for a proportion of diagnostic procedures involving radiation when all related requirements are met; otherwise, the regular licensing procedure should be used. The new radiation protection law, which will enter into force on the 31st of december 2018, provides a notification procedure in addition to deadlines for both the notification and the licensing procedures. In the article, the authors consider how eligible studies involving applications of radiation that are legally not admissible at present may be feasible in the future, while still ensuring a high protection level for study participants.

  1. Current regulatory and licensing status for byproduct sources, facilities and applications

    International Nuclear Information System (INIS)

    Tingey, G.L.; Jensen, G.A.; Hazelton, R.F.

    1985-02-01

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig

  2. Oligothiophenes as Fluorescent Markers for Biological Applications

    Directory of Open Access Journals (Sweden)

    Antonio Manetto

    2012-01-01

    Full Text Available This paper summarizes some of our results on the application of oligothiophenes as fluorescent markers for biological studies. The oligomers of thiophene, widely known for their semiconductor properties in organic electronics, are also fluorescent compounds characterized by chemical and optical stability, high absorbance and quantum yield. Their fluorescent emission can be easily modulated via organic synthesis by changing the number of thiophene rings and the nature of side-chains. This review shows how oligothiophenes can be derivatized with active groups such as phosphoramidite, N-hydroxysuccinimidyl and 4-sulfotetrafluorophenyl esters, isothiocyanate and azide by which the (biomolecules of interest can be covalently bound. This paper also describes how molecules such as oligonucleotides, proteins and even nanoparticles, tagged with oligothiophenes, can be used in experiments ranging from hybridization studies to imaging of fixed and living cells. Finally, a few multilabeling experiments are described.

  3. Nuclear Regulatory Commission staff development of the license application review plan for a high-level radioactive waste repository

    International Nuclear Information System (INIS)

    Johnson, R.L.; Holonich, J.J.; Lee, M.P.; Delligatti, M.S.

    1993-01-01

    The Nuclear Regulatory Commission staff has recently started a new initiative to develop the License Application Review Plan (LARP) which the staff will use in its reviews of the U.S. Department of Energy's (DOE's) license application (LA) for a geologic repository for the disposal of high-level radioactive waste (HLW). This paper describes the staff's approach for developing the LARP, the development schedule and current status, the organization and content of the LARP, and the staff's LA review strategy. Therefore, it gives a preview of the draft LARP which will be made available in late 1993. It also describes how the LARP will be used as guidance to the staff in conducting reviews of regulatory and technical issues important to the licensing of a geologic repository. Finally, the benefits to the NRC staff, DOE, and other parties are discussed

  4. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1987-05-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  5. Applicability of IBAMA normative instruction 146-2007 to pipeline environmental licensing

    Energy Technology Data Exchange (ETDEWEB)

    Basbaum, Marcos A.; Fonseca, Renata A.A. [Servicos de Engenharia Emilio Baumgart Ltda. (SEEBLA), Rio de Janeiro, RJ(Brazil)], e-mail: mbasbaum.seebla@petrobras.com.br, e-mail: renataamorim.seebla@petrobras.com.br; Torggler, Bianca F.; Fernandes, Renato; Guimaraes, Ricardo Z.P. [Petroleo do Brasil S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)], e-mail: torggler@petrobras.com.br, e-mail: renatofer@petrobras.com.br, e-mail: rzaluar@petrobras.com.br

    2009-07-01

    PETROBRAS has been conducting several wildlife programs in response to environmental licensing requirements from IBAMA (Brazilian environmental agency). Since 2007, IBAMA has been requiring the application of the Normative Instruction n. 146 (NI), which establishes criteria for wildlife management in the influence areas of new enterprises. However, experience from PETROBRAS has shown that many of the NI articles are not applicable to pipelines. Thus, a critical analysis of this NI was done based on data from company's wildlife programs. Our analysis indicated that the main NI items that do not apply to pipelines are: 1 - Animal rescue programs in deforested areas and selection of release areas, 2 - More than two fauna monitoring campaigns a year, 3 - Monitoring programs involving all groups of terrestrial vertebrates and also invertebrate classes. The non-applicability of these items is due to: 1 - The majority of pipelines are built in areas without significant native vegetation or with small fragments only, which are usually in secondary stage of ecological succession. Most pipelines scarcely involve removal of primary vegetation, 2 - Pipelines have an influence area restricted to a range of 800 m and the construction directly affects only strips from 20 m to 30 m, 3 - The most relevant impacts associated with pipelines are temporary, and do not persist during their operation. (author)

  6. Licensing issues

    International Nuclear Information System (INIS)

    Roberts, J.P.; Desell, L.J.; Birch, M.L.; Berkowitz, L.; Bader, J.F.

    1992-01-01

    To provide guidance for the Department of Energy's (DOE) Civilian Radioactive Waste Management Program, the Nuclear Regulatory Commission (NRC) has issued a draft regulatory guide on the Format and Content for the License Application for the High-Level Waste Repository (FCRG). To facilitate the development of the FCRG, NRC suggested that DOE use the draft guide as the basis for preparing an annotated outline for a license application. DOE is doing so using an iterative process called the Annotated Outline Initiative. DOE;s use of the Initiative will assist in achieving the desired incorporation of actual experience in the FCRG, contribute to the development of shared interpretation and understanding of NRC regulations, and provide other important programmatic benefits described in this paper

  7. Automation of the DoD Export License Application Review Process

    National Research Council Canada - National Science Library

    Young, Shelton

    2002-01-01

    .... The overall audit objective was to determine whether Federal automation programs supporting the export license and review process could be used to establish a common electronic interface creating...

  8. 78 FR 30914 - Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-05-23

    .... Description of Request: Grand River Dam Authority (GRDA) requests a temporary variance, for the year 2013, to... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 1494-416] Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting Comments, Motions To...

  9. 77 FR 39675 - Applications for Licensing as a Non-Leveraged Rural Business Investment Company Under the Rural...

    Science.gov (United States)

    2012-07-05

    ... large 3-ring binder. Label the binders with the RBIC's name. Submit one complete and unbound one-sided hard copy of the MAQ and Exhibits suitable for photocopying (i.e., no hole punches, staples, paper clips, tabs or binders). Applicants must enclose in their submission a nonrefundable licensing fee of...

  10. 78 FR 4467 - UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3...

    Science.gov (United States)

    2013-01-22

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3, Exemption 1.0 Background UniStar Nuclear Energy (UNE), on behalf of Calvert Cliffs Nuclear Project, LLC and UniStar Nuclear Operating Services...

  11. 76 FR 81994 - UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit...

    Science.gov (United States)

    2011-12-29

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit 3; Exemption 1.0 Background: UniStar Nuclear Energy (UNE) submitted to the U.S. Nuclear Regulatory Commission (NRC or the Commission ) a...

  12. 76 FR 11522 - In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear...

    Science.gov (United States)

    2011-03-02

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-029-COL, 52-030-COL] In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear Power Plant, Units 1 and 2... by the Nuclear Regulatory Commission staff in this case. Mr. Dehmel has not previously performed any...

  13. 75 FR 69063 - Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-11-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 1432-010] Port Bailey Wild... Motions To Intervene November 3, 2010. On October 22, 2010, Port Bailey Wild Enterprises, LLC (transferor) and PB Energy, Inc. (transferee) filed a joint application for transfer of license for the Dry Spruce...

  14. 78 FR 61984 - Copper Valley Electric Association, Inc.; Notice of Application To Amend License and Accepted for...

    Science.gov (United States)

    2013-10-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13124-005] Copper Valley...: Amendment to License. b. Project No: 13124-005. c. Date Filed: September 27, 2013. d. Applicant: Copper..., Copper Valley Electric Association, Inc., P.O. Box 45, Mile 187 Glenn Highway, Glennallen, AK 99588, (907...

  15. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Science.gov (United States)

    2013-03-06

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11169-029] Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower...

  16. 78 FR 5196 - Notice of Invitation To Participate; Exploration for Coal in Colorado License Application COC-75642

    Science.gov (United States)

    2013-01-24

    ...] Notice of Invitation To Participate; Exploration for Coal in Colorado License Application COC-75642... Mineral Leasing Act of 1920, as amended by the Federal Coal Leasing Amendments Act of 1976, and to Bureau..., Colorado. DATES: Any party electing to participate in this exploration program must send written notice to...

  17. 76 FR 55701 - Notice of Invitation to Participate; Exploration for Coal in Colorado License Application COC-74895

    Science.gov (United States)

    2011-09-08

    ...] Notice of Invitation to Participate; Exploration for Coal in Colorado License Application COC-74895... Mineral Leasing Act of 1920, as amended by the Federal Coal Leasing Amendments Act of 1976, and to Bureau... coal deposits owned by the United States of America in lands located in Routt County, Colorado. DATES...

  18. Biological fuel cells and their applications

    OpenAIRE

    Shukla, AK; Suresh, P; Berchmans, S; Rajendran, A

    2004-01-01

    One type of genuine fuel cell that does hold promise in the long-term is the biological fuel cell. Unlike conventional fuel cells, which employ hydrogen, ethanol and methanol as fuel, biological fuel cells use organic products produced by metabolic processes or use organic electron donors utilized in the growth processes as fuels for current generation. A distinctive feature of biological fuel cells is that the electrode reactions are controlled by biocatalysts, i.e. the biological redox-reac...

  19. Standard format and content for the physical protection section of a license application (for facilities other than nuclear power plants)

    International Nuclear Information System (INIS)

    1976-06-01

    The document presented has been prepared as an aid to uniformity and completeness in the preparation and review of the physical protection section of license applications. It is applicable to fuel reprocessing plants, fuel manufacturing plants, SNM tranportation, or other special nuclear material operations involving the possession and use of uranium 235 (contained in uranium enriched to 20 percent or more in the U-235 isotope), uranium 233, or plutonium alone or in any combination in a quantity of 5000 grams or more computed by the formula: grams = (grams contained U-235) + 2.5 (grams U-233 + grams plutonium). The document is not intended to be used for nuclear power plants. The information specified is the minimum needed for a license application. Additional information may be required for completion of the staff review of a particular application

  20. 47 CFR 97.21 - Application for a modified or renewed license grant.

    Science.gov (United States)

    2010-10-01

    ... name, club name, license trustee name or license custodian name in accordance with § 1.913 of this... form to a Club Station Call Sign Administrator who must submit the information thereon to the FCC in an electronic batch file. The Club Station Call Sign Administrator must retain the collected information for at...

  1. Detector applications in medecine and biology

    CERN Document Server

    Del Guerra, Alberto

    1995-01-01

    In recent years new diagnostic and therapeutic methods have been attracting more and more dedicated attention by the scientific community.The goal is a better understanding of the anatomy, physiology and pathology of the human being in an effort to find more appropriate medical prevention, diagnosis and therapy.Many of the achievements obtained so far derive from the use and the optimisation of detectors and techniques,which originated in the other fields of physics. The spin-off of High Energy Physics to Medical Physics has been particularly relevant in the field of detectors for medical imaging and especially for medical imaging with ionizing radiation. In this series of lectures,starting from the requests of each technique and or application I will attempt to present a survey of the detectors for medecine and biology. Various fields of medical imaging will be touched : radiology,digital radiography,mammography and radiotherapy. The capabilities of the major types of detectors (1-D and 2-D position sensitiv...

  2. Safety case for license application for a final repository: The French example

    International Nuclear Information System (INIS)

    Boissier, Fabrice; Voinis, Sylvie

    2014-01-01

    The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste (HLW and ILW). Twenty years of R and D work and conceptual and basic studies since the first French Act of 1991 led, in particular, to a feasibility demonstration in 2005. According to the French Act on Radioactive Waste of 28 of June 2006, Andra shall design a reversible repository in order to apply for license in 2015. In response to this demand, Andra developed the industrial project known as 'Cigeo', a reversible geological disposal facility for HLW and ILW located in Meuse/Haute-Marne. Two years before applying for authorisation, Andra's project is now focusing on three main targets: developing Cigeo's industrial design, preparing the authorisation process through increased exchanges with stakeholders and the preparation of a safety case to support authorisation application. The latter draws on the previous safety cases of 2005 and 2009, which give a sound basis to assess Cigeo's safety, both for the operational and post-closure periods. In this new stage of the project, the challenging issues for the preparation of the safety case are the following: - to identify the various regulatory frameworks (nuclear and non-nuclear) and guides applicable to the facility; - to ensure that the industrial design complies in particular with the safety requirements as presented in the safety case and its supporting safety assessment; - to identify crucial inputs (R and D, tests,...) needed to support the authorisation application, in particular, to bring convincing arguments to assess the technical feasibility of the design and when appropriate its ability to meet the safety requirements; - to ensure that all the requirements from previous regulatory and peer reviews (national and international?) are taken into account. (authors)

  3. Applicability of Computational Systems Biology in Toxicology

    DEFF Research Database (Denmark)

    Kongsbak, Kristine Grønning; Hadrup, Niels; Audouze, Karine Marie Laure

    2014-01-01

    be used to establish hypotheses on links between the chemical and human diseases. Such information can also be applied for designing more intelligent animal/cell experiments that can test the established hypotheses. Here, we describe how and why to apply an integrative systems biology method......Systems biology as a research field has emerged within the last few decades. Systems biology, often defined as the antithesis of the reductionist approach, integrates information about individual components of a biological system. In integrative systems biology, large data sets from various sources...... and databases are used to model and predict effects of chemicals on, for instance, human health. In toxicology, computational systems biology enables identification of important pathways and molecules from large data sets; tasks that can be extremely laborious when performed by a classical literature search...

  4. Neutron Scattering in Biology Techniques and Applications

    CERN Document Server

    Fitter, Jörg; Katsaras, John

    2006-01-01

    The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

  5. Development of RESRAD probabilistic computer codes for NRC decommissioning and license termination applications

    International Nuclear Information System (INIS)

    Chen, S. Y.; Yu, C.; Mo, T.; Trottier, C.

    2000-01-01

    In 1999, the US Nuclear Regulatory Commission (NRC) tasked Argonne National Laboratory to modify the existing RESRAD and RESRAD-BUILD codes to perform probabilistic, site-specific dose analysis for use with the NRC's Standard Review Plan for demonstrating compliance with the license termination rule. The RESRAD codes have been developed by Argonne to support the US Department of Energy's (DOEs) cleanup efforts. Through more than a decade of application, the codes already have established a large user base in the nation and a rigorous QA support. The primary objectives of the NRC task are to: (1) extend the codes' capabilities to include probabilistic analysis, and (2) develop parameter distribution functions and perform probabilistic analysis with the codes. The new codes also contain user-friendly features specially designed with graphic-user interface. In October 2000, the revised RESRAD (version 6.0) and RESRAD-BUILD (version 3.0), together with the user's guide and relevant parameter information, have been developed and are made available to the general public via the Internet for use

  6. Qualification of the coupled RELAP5/PANTHER/COBRA code package for licensing applications

    International Nuclear Information System (INIS)

    Schneidesch, C.R.; Zhang Jinzhao

    2004-01-01

    A coupled thermal hydraulics-neutronics code package has been developed at Tractebel Engineering (TE), in which the best-estimate thermal-hydraulic system code, RELAP5/mod2.5, is coupled with the full three-dimensional reactor core kinetics code, PANTHER, via the dynamic data exchange interface, TALINK. The Departure from Nucleate Boiling Ratio (DNBR) is calculated by the sub-channel thermal-hydraulic analysis code COBRA-3C. The package provides the capability to accurately simulate the key physical phenomena in nuclear power plant accidents with strong asymmetric behaviours and system-core interactions. This paper presents the TE coupled code package and focuses on the methodology followed for qualifying it for licensing applications. The qualification of the coupling demonstrated the robustness achieved by the combined 3-D neutron kinetics/system T-H code package for transient simulations. The coupled TE code package has been qualified and will be used at Tractebel Engineering (TE) for analyzing asymmetric PWR accidents with strong core-system interactions

  7. How a regulator is preparing for reviewing a license application file: The case of ASN

    International Nuclear Information System (INIS)

    Tanguy, Loic

    2014-01-01

    The French Nuclear Safety Authority (ASN) is an independent administrative authority. It prepares regulation pertaining to the management of radioactive waste, monitors the control of safety of basic nuclear installations that produce or treat waste or are involved in their disposal and performs inspections of waste producers (EDF, AREVA, CEA, hospitals, research centres, etc.) and Andra, the French National Radioactive Waste Management Agency. It regulates the overall system set up by Andra for accepting waste from producers and assesses waste management policy and the practices of radioactive waste producers. It reviews license applications and authorises commissioning of nuclear installations. In order to review technical documents, ASN benefits from the expertise of technical support organisations. The French Institute for Radiation Protection and Nuclear Safety (IRSN) is the main such organisation. ASN has been making efforts to diversify its experts for several years. In preparing its decisions, ASN also calls on the opinions and recommendations of seven Advisory Committees of Experts (GPE), with expert knowledge in the areas of waste, nuclear pressure equipment, medical exposure, non-medical radiation protection, reactors, transport, and laboratories and nuclear plants. ASN consults the GPEs in preparing its main decisions. In particular, they review the preliminary, provisional and final safety analysis reports for each nuclear installation. They can also be consulted about changes in regulations or doctrine. (authors)

  8. Applications of contact predictions to structural biology

    Directory of Open Access Journals (Sweden)

    Felix Simkovic

    2017-05-01

    Full Text Available Evolutionary pressure on residue interactions, intramolecular or intermolecular, that are important for protein structure or function can lead to covariance between the two positions. Recent methodological advances allow much more accurate contact predictions to be derived from this evolutionary covariance signal. The practical application of contact predictions has largely been confined to structural bioinformatics, yet, as this work seeks to demonstrate, the data can be of enormous value to the structural biologist working in X-ray crystallography, cryo-EM or NMR. Integrative structural bioinformatics packages such as Rosetta can already exploit contact predictions in a variety of ways. The contribution of contact predictions begins at construct design, where structural domains may need to be expressed separately and contact predictions can help to predict domain limits. Structure solution by molecular replacement (MR benefits from contact predictions in diverse ways: in difficult cases, more accurate search models can be constructed using ab initio modelling when predictions are available, while intermolecular contact predictions can allow the construction of larger, oligomeric search models. Furthermore, MR using supersecondary motifs or large-scale screens against the PDB can exploit information, such as the parallel or antiparallel nature of any β-strand pairing in the target, that can be inferred from contact predictions. Contact information will be particularly valuable in the determination of lower resolution structures by helping to assign sequence register. In large complexes, contact information may allow the identity of a protein responsible for a certain region of density to be determined and then assist in the orientation of an available model within that density. In NMR, predicted contacts can provide long-range information to extend the upper size limit of the technique in a manner analogous but complementary to experimental

  9. Computational structural biology: methods and applications

    National Research Council Canada - National Science Library

    Schwede, Torsten; Peitsch, Manuel Claude

    2008-01-01

    ... sequencing reinforced the observation that structural information is needed to understand the detailed function and mechanism of biological molecules such as enzyme reactions and molecular recognition events. Furthermore, structures are obviously key to the design of molecules with new or improved functions. In this context, computational structural biology...

  10. Aspergilli: Systems biology and industrial applications

    DEFF Research Database (Denmark)

    Knuf, Christoph; Nielsen, Jens

    2012-01-01

    possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology....

  11. Biological Applications in the Mathematics Curriculum

    Science.gov (United States)

    Marland, Eric; Palmer, Katrina M.; Salinas, Rene A.

    2008-01-01

    In this article we provide two detailed examples of how we incorporate biological examples into two mathematics courses: Linear Algebra and Ordinary Differential Equations. We use Leslie matrix models to demonstrate the biological properties of eigenvalues and eigenvectors. For Ordinary Differential Equations, we show how using a logistic growth…

  12. Review of Biological Network Data and Its Applications

    Directory of Open Access Journals (Sweden)

    Donghyeon Yu

    2013-12-01

    Full Text Available Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.

  13. Applications of thermal neutron scattering in biology, biochemistry and biophysics

    International Nuclear Information System (INIS)

    Worcester, D.L.

    1977-01-01

    Biological applications of thermal neutron scattering have increased rapidly in recent years. The following categories of biological research with thermal neutron scattering are presently identified: crystallography of biological molecules; neutron small-angle scattering of biological molecules in solution (these studies have already included numerous measurements of proteins, lippoproteins, viruses, ribosomal subunits and chromatin subunit particles); neutron small-angle diffraction and scattering from biological membranes and membrane components; and neutron quasielastic and inelastic scattering studies of the dynamic properties of biological molecules and materials. (author)

  14. 75 FR 23808 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-05-04

    ... most adverse moderation conditions feasible by unborated water. By meeting this criteria, the removal... Risk Assessment in Risk-Informed Decisions On Plant-Specific Changes to the Licensing Basis,'' and RG 1...

  15. 76 FR 77565 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-12-13

    ... intervene shall be filed in accordance with the Commission's ''Rules of Practice for Domestic Licensing...- conservative emergency diesel generator fuel oil supply volumes, incorporate portions of Technical... of the associated Technical Specifications to require an adequate emergency diesel generator and...

  16. NUPLEX Licensing Subcommittee

    International Nuclear Information System (INIS)

    Edwards, D.W.; Allen, S.R.

    1988-01-01

    The NUPLEX Licensing Subcommittee was organized to seek a formal license renewal mechanism that institutionalizes the current licensing basis and consequent level of safety of a plant as the legitimate standard for acceptance and approval of an application for extended operation. Along with defining the most workable approach to and scope of review for license renewal, this paper explains the reasons why a regulatory framework is needed by the early 1990s. The initial results of development work on two key issues, licensing criteria and hearing process, are also presented. at this point six potential license renewal criteria have emerged: evaluation of existing monitoring/maintenance programs, revalidation of current licensing basis, conformance to special regulations, evaluation to a safety goal, plant performance history, and environmental assessment. The work on a hearing process has led to the development of two models for future consideration: hybrid legislative and hybrid adjudicatory

  17. Structural Biology and Molecular Applications Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research and development in this area focuses on enabling technologies, models, and methodologies to support basic and applied cancer research.

  18. Magnetically responsive biological materials and their applications

    Czech Academy of Sciences Publication Activity Database

    Šafařík, Ivo; Pospíšková, K.; Baldíková, E.; Šafaříková, Miroslava

    2016-01-01

    Roč. 7, č. 4 (2016), s. 254-261 ISSN 0976-3961 Institutional support: RVO:60077344 Keywords : adsorbents * biological materials * carriers * magnetic modification * whole-cell biocatalyst Subject RIV: EI - Biotechnology ; Bionics

  19. Proceedings of biological applications of relativistic nuclei

    International Nuclear Information System (INIS)

    Alard, J.P.; Montret, J.C.

    1993-01-01

    The workshop BARN 92 on various aspects of radiation treatment of tumours and of biological radiation effects on living system hosted 38 short papers. Each is indexed and abstracted separately for the INIS database. (R.P.)

  20. Marine Carotenoids: Biological Functions and Commercial Applications

    NARCIS (Netherlands)

    Vilchez, C.; Forján, E.; Cuaresma, M.; Bédmar, F.; Garbayo, I.; Vega, J.M.

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological

  1. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1993-01-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  2. A biological compression model and its applications.

    Science.gov (United States)

    Cao, Minh Duc; Dix, Trevor I; Allison, Lloyd

    2011-01-01

    A biological compression model, expert model, is presented which is superior to existing compression algorithms in both compression performance and speed. The model is able to compress whole eukaryotic genomes. Most importantly, the model provides a framework for knowledge discovery from biological data. It can be used for repeat element discovery, sequence alignment and phylogenetic analysis. We demonstrate that the model can handle statistically biased sequences and distantly related sequences where conventional knowledge discovery tools often fail.

  3. 75 FR 54330 - Intent To Grant an Exclusive Field of Use License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-09-07

    ... DEPARTMENT OF DEFENSE Department of the Army Intent To Grant an Exclusive Field of Use License of a U.S. Government-Owned Patent Application AGENCY: Department of the Army, DoD. ACTION: Notice... intent to grant an exclusive, revocable license for the field of use in the research reagent market to...

  4. 75 FR 39668 - Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-07-12

    ... DEPARTMENT OF DEFENSE Department of the Army Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application AGENCY: Department of the Army, DoD. ACTION: Notice... intent to grant a field of use exclusive, revocable license for the field of shigella vaccine development...

  5. Applicability of Item Response Theory to the Korean Nurses' Licensing Examination

    Directory of Open Access Journals (Sweden)

    Geum-Hee Jeong

    2005-06-01

    Full Text Available To test the applicability of item response theory (IRT to the Korean Nurses' Licensing Examination (KNLE, item analysis was performed after testing the unidimensionality and goodness-of-fit. The results were compared with those based on classical test theory. The results of the 330-item KNLE administered to 12,024 examinees in January 2004 were analyzed. Unidimensionality was tested using DETECT and the goodness-of-fit was tested using WINSTEPS for the Rasch model and Bilog-MG for the two-parameter logistic model. Item analysis and ability estimation were done using WINSTEPS. Using DETECT, Dmax ranged from 0.1 to 0.23 for each subject. The mean square value of the infit and outfit values of all items using WINSTEPS ranged from 0.1 to 1.5, except for one item in pediatric nursing, which scored 1.53. Of the 330 items, 218 (42.7% were misfit using the two-parameter logistic model of Bilog-MG. The correlation coefficients between the difficulty parameter using the Rasch model and the difficulty index from classical test theory ranged from 0.9039 to 0.9699. The correlation between the ability parameter using the Rasch model and the total score from classical test theory ranged from 0.9776 to 0.9984. Therefore, the results of the KNLE fit unidimensionality and goodness-of-fit for the Rasch model. The KNLE should be a good sample for analysis according to the IRT Rasch model, so further research using IRT is possible.

  6. Exploiting for medical and biological applications

    Science.gov (United States)

    Giano, Michael C.

    Biotherapeutics are an emerging class of drug composed of molecules ranging in sizes from peptides to large proteins. Due to their poor stability and mucosal membrane permeability, biotherapeutics are administered by a parenteral method (i.e., syringe, intravenous or intramuscular). Therapeutics delivered systemically often experience short half-lives. While, local administration may involve invasive surgical procedures and suffer from poor retention at the site of application. To compensate, the patient receives frequent doses of highly concentrated therapeutic. Unfortunately, the off-target side effects and discomfort associated with multiple injections results in poor patient compliance. Therefore, new delivery methods which can improve therapeutic retention, reduce the frequency of administration and may aid in decreasing the off-target side effects is a necessity. Hydrogels are a class of biomaterials that are gaining interests for tissue engineering and drug delivery applications. Hydrogel materials are defined as porous, 3-dimensional networks that are primarily composed of water. Generally, they are mechanically rigid, cytocompatible and easily chemically functionalized. Collectively, these properties make hydrogels fantastic candidates to perform as drug delivery depots. Current hydrogel delivery systems physically entrap the target therapeutic which is then subsequently released over time at the site of administration. The swelling and degradation of the material effect the diffusion of the therapy from the hydrogel, and therefore should be controlled. Although these strategies provide some regulation over therapeutic release, full control of the delivery is not achieved. Newer approaches are focused on designing hydrogels that exploit known interactions, covalently attach the therapy or respond to an external stimulus in an effort to gain improved control over the therapy's release. Unfortunately, the biotherapeutic is typically required to be chemically

  7. Synthetic Biology: Applications in the Food Sector.

    Science.gov (United States)

    Tyagi, Ashish; Kumar, Ashwani; Aparna, S V; Mallappa, Rashmi H; Grover, Sunita; Batish, Virender Kumar

    2016-08-17

    Synthetic biology also termed as "genomic alchemy" represents a powerful area of science that is based on the convergence of biological sciences with systems engineering. It has been fittingly described as "moving from reading the genetic code to writing it" as it focuses on building, modeling, designing and fabricating novel biological systems using customized gene components that result in artificially created genetic circuitry. The scientifically compelling idea of the technological manipulation of life has been advocated since long time. Realization of this idea has gained momentum with development of high speed automation and the falling cost of gene sequencing and synthesis following the completion of the human genome project. Synthetic biology will certainly be instrumental in shaping the development of varying areas ranging from biomedicine, biopharmaceuticals, chemical production, food and dairy quality monitoring, packaging, and storage of food and dairy products, bioremediation and bioenergy production, etc. However, potential dangers of using synthetic life forms have to be acknowledged and adoption of policies by the scientific community to ensure safe practice while making important advancements in the ever expanding field of synthetic biology is to be fully supported and implemented.

  8. Environmental and biological applications of microplasmas

    International Nuclear Information System (INIS)

    Becker, K; Koutsospyros, A; Yin, S-M; Christodoulatos, C; Abramzon, N; Joaquin, J C; Brelles-Marino, G

    2005-01-01

    Stable glow-type discharge plasmas at elevated pressures can be generated and maintained easily when the plasma is spatially confined to cavities with critical dimensions below 1 mm ('microplasmas'). We studied the properties of several atmospheric-pressure microplasmas and their use in the remediation of volatile organic compounds (VOCs) and biological decontamination. The VOCs studied include individual prototypcal aliphatic and aromatic compounds as well as mixtures such as BTEX (benzene, toluene, ethylbenzene and xylene). The biological systems under study included individual bacteria as well as bacterial biofilms, which are highly structured communities of bacteria that are very resistant to antibiotics, germicides, and other conventional forms of destruction

  9. Hidden Markov processes theory and applications to biology

    CERN Document Server

    Vidyasagar, M

    2014-01-01

    This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. The book starts from first principles, so that no previous knowledge of probability is necessary. However, the work is rigorous and mathematical, making it useful to engineers and mathematicians, even those not interested in biological applications. A range of exercises is provided, including drills to familiarize the reader with concepts and more advanced problems that require deep thinking about the theory. Biological applications are t

  10. Application of computational intelligence to biology

    CERN Document Server

    Sekhar, Akula

    2016-01-01

    This book is a contribution of translational and allied research to the proceedings of the International Conference on Computational Intelligence and Soft Computing. It explains how various computational intelligence techniques can be applied to investigate various biological problems. It is a good read for Research Scholars, Engineers, Medical Doctors and Bioinformatics researchers.

  11. Guide for the preparation of applications for special nuclear material licenses of less than critical mass quantities - July 1976

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This guide describes the type of information needed to evaluate an application for a specific license for receipt, possession, use, and transfer of special nuclear material. It is intended for applicants requesting authorization to possess and use up to 2000 grams of plutonium, total, in the form of sealed plutonium-beryllium neutron sources, and any special nuclear material in quantities and forms not sufficient to form a critical mass. The latter quantities are considered to be 350 grams of contained uranium-235, 200 grams of uranium-233, 200 grams of plutonium (in any form other than plutonium-beryllium neutron sources) or any combination of them

  12. Assessment of variable application rates of biological amendment ...

    African Journals Online (AJOL)

    Assessment of variable application rates of biological amendment substances on establishment and growth characteristics of maize plants. ... Hence, a greenhouse experiment was conducted in 2008 to assess the effects of variable rates (50, 75 and 100% of the recommended rates) of industrial manufactured biological ...

  13. Biological Treatment of Drinking Water: Applications, Advantages and Disadvantages

    Science.gov (United States)

    The fundamentals of biological treatment are presented to an audience of state drinking water regulators. The presentation covers definitions, applications, the basics of bacterial metabolism, a discussion of treatment options, and the impact that implementation of these options...

  14. 76 FR 52699 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-08-23

    ... proposes to credit the automatic trip of the main turbine upon the initiation of a manual reactor trip for... credited manual reactor trip action that is part of the current licensing basis. Considerable defense-in... more robust AREVA Advanced W17 high thermal performance (HTP) fuel at Sequoyah Nuclear Plant (SQN...

  15. 75 FR 61521 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-10-05

    ... revises the charcoal testing criteria in Technical Specification 5.5.9, ``Ventilation Filter Testing... staffing from two to four, allow in-plant protective actions to be performed by personnel assigned to other functions, and replace a Mechanical Maintenance person with a Non-Licensed Operator. Date of issuance...

  16. Guidance for the licensing procedure concerning the application of radiographic equipment

    International Nuclear Information System (INIS)

    1987-01-01

    According to article 4 of the Ordinance on the Implementation of Atomic Safety and Radiation Protection dated 11 October 1984 the operation of radiographic equipment has to be licensed. The personnel and material requirements that are to be fulfilled by a licensee prior to commissioning X-ray or gamma equipment, are discussed in detail

  17. 76 FR 73727 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-11-29

    ..., Donald C. Cook Nuclear Plant, Unit 2 (DCCNP-2), Berrien County, Michigan; Date of amendment request... Counsel, Indiana Michigan Power Company, One Cook Place, Bridgman, MI 49106. NRC Acting Branch Chief: Thomas J. Wengert. Notice of Issuance of Amendments to Facility Operating Licenses During the period...

  18. 76 FR 61391 - Biweekly Notice Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-10-04

    ... ''Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR part 2. Interested person(s) should... to be operable in MODES 1, 2, and 3, as well as in MODE 4 when a steam generator (SG) is relied upon... stored diesel fuel oil inventory will require that a 7 day supply be available for each diesel generator...

  19. 76 FR 39136 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2011-07-05

    ... the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR part 2. Interested... Generator (SG) Program,'' to exclude a portion of the tubes below the top of the steam generator tubesheet from periodic steam generator tube inspections during Refueling Outage 14 and the subsequent operating...

  20. 75 FR 37471 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-06-29

    ... accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR Part 2... Specifications (TSs) to extend the allowed outage time (AOT) for the ``A'' and ``B'' emergency diesel generators... emergency diesel generators are safety related components which provide backup electrical power supply to...

  1. 75 FR 48370 - Biweekly Notice Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-08-10

    ... ensures the timely transfer of plant safety system loads to the Emergency Diesel Generators in the event a... a margin of safety. The basis for this proposed determination for each amendment request is shown... Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR Part 2. Interested person(s...

  2. 47 CFR 74.113 - Supplementary reports with application for renewal of license.

    Science.gov (United States)

    2010-10-01

    ... renewal of license. 74.113 Section 74.113 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... covered. (4) Power employed, field intensity measurements and visual and aural observations and the types... respective types of transmissions. (5) Estimated degree of public participation in reception and the results...

  3. 75 FR 52039 - Biweekly Notice Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-08-24

    ... the design earthquake, the double design earthquake, the Hosgri earthquake, and the loss-of-coolant... by the Chief Administrative Judge of the Atomic Safety and Licensing Board Panel, will rule on the....m. Eastern Time on the due date. Upon receipt of a transmission, the E-Filing system time-stamps the...

  4. 75 FR 13786 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-03-23

    ... earthquake (DE), double design earthquake (DDE), Hosgri earthquake (HE), and loss of coolant accident (LOCA... Administrative Judge of the Atomic Safety and Licensing Board Panel, will rule on the request and/or petition...-Filing system no later than 11:59 p.m. Eastern Time on the due date. Upon receipt of a transmission, the...

  5. Guide for the preparation of applications for licenses for the use of self-contained dry source-storage irradiators. Second proposed Revision 1

    International Nuclear Information System (INIS)

    Bassin, N.

    1984-10-01

    The purpose of this regulatory guide is to provide assistance to applicants and licensees in preparing applications for new licenses, license amendments, and license renewals for the use of self-contained dry source-storage irradiators. These irradiators are constructed so that the sealed sources and the material being irradiated are contained in a shielded volume and there is no external radiation beam during the use of the irradiator. The radioisotopes most commonly used for these irradiators are cobalt-60 and cesium-137

  6. Stochastic chemical kinetics theory and (mostly) systems biological applications

    CERN Document Server

    Érdi, Péter; Lente, Gabor

    2014-01-01

    This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.

  7. Grafting of Porous Polymers for Biological Applications

    Energy Technology Data Exchange (ETDEWEB)

    Smolko, E. E. [Comisión Nacional de Energía Atómica, Buenos Aires (Argentina); Grasselli, M. [Dpto. LaMaBio, Dpto. de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires (Argentina)

    2009-07-01

    Research on application of radiation processing to polymers is mainly focused by the National Atomic Commission (CNEA). The Agricultural and Industrial Applications Laboratory Unit operates at the Ezeiza Atomic Center since the end of 1980s. Since 1997 a new research group headed by Dr. O. Cascone and Dr. M. Grasselli, devoted to downstream processing of proteins from the University of Buenos Aires, was involved in the implementation of grafting techniques in collaboration with Dr. E. Smolko from CNEA. In 1999 Dr. M. Grasselli moved to the Universidad Nacional de Quilmes where he continued working on application of gamma radiation to materials for biotechnological process. (author)

  8. Grafting of Porous Polymers for Biological Applications

    International Nuclear Information System (INIS)

    Smolko, E.E.; Grasselli, M.

    2009-01-01

    Research on application of radiation processing to polymers is mainly focused by the National Atomic Commission (CNEA). The Agricultural and Industrial Applications Laboratory Unit operates at the Ezeiza Atomic Center since the end of 1980s. Since 1997 a new research group headed by Dr. O. Cascone and Dr. M. Grasselli, devoted to downstream processing of proteins from the University of Buenos Aires, was involved in the implementation of grafting techniques in collaboration with Dr. E. Smolko from CNEA. In 1999 Dr. M. Grasselli moved to the Universidad Nacional de Quilmes where he continued working on application of gamma radiation to materials for biotechnological process. (author)

  9. Facilities license application record data as of April 1, 1981. Tri-annual report 30 Nov 80-1 Apr 81

    International Nuclear Information System (INIS)

    1981-06-01

    The FLAR is divided into three parts as follows: Part I - The first part is a listing of all operating licenses, authorizations and construction permits in effect plus applications pending; Part II - The second part is a listing of applications that have been withdrawn or denied, and licenses and construction permits terminated or revoked; and Part III - The third part is a listing of research, test and power reactors for export

  10. Magnetic nanoparticles as potential candidates for biomedical and biological applications.

    Science.gov (United States)

    Zeinali Sehrig, Fatemeh; Majidi, Sima; Nikzamir, Nasrin; Nikzamir, Nasim; Nikzamir, Mohammad; Akbarzadeh, Abolfazl

    2016-05-01

    Magnetic iron oxide nanoparticles have become the main candidates for biomedical and biological applications, and the application of small iron oxide nanoparticles in in vitro diagnostics has been practiced for about half a century. Magnetic nanoparticles (MNPs), in combination with an external magnetic field and/or magnetizable grafts, allow the delivery of particles to the chosen target area, fix them at the local site while the medication is released, and act locally. In this review, we focus mostly on the potential use of MNPs for biomedical and biotechnological applications, and the improvements made in using these nanoparticles (NPs) in biological applications.

  11. Licensing process in Finland

    International Nuclear Information System (INIS)

    Tiippana, Petteri

    2011-01-01

    In accordance with the Nuclear Energy Act, the use of nuclear energy constitutes operations subject to license. The licensing process and conditions for granting a license is defined in the legislation. The licenses are applied from and granted by the Government. This paper discusses briefly the licensing process in Finland and also the roles and responsibilities of main stakeholders in licensing. Licensing of a nuclear power plant in Finland has three steps. The first step is the Decision in Principle (DiP). Goal of DiP is to decide whether using nuclear power is for the overall good for the Finnish society. The second step is Construction License (CL) and the goal of CL phase is to determine whether the design of the proposed plant is safe and that the participating organisations are capable of constructing the plant to meet safety goals. The third step is the Operating License (OL) and the goal of the OL phase is to determine whether the plant operates safely and licensee is capable to operate the plant safely. Main stakeholders in the licensing process in Finland are the utility (licensee) interested in using nuclear power in Finland, Ministry of Employment and the Economy (MEE), Government, Parliament, STUK, the municipality siting the plant and the general public. Government grants all licenses, and Parliament has to ratify Government's Decision in Principle. STUK has to assess the safety of the license applications in each step and give statement to the Ministry. Municipality has to agree to site the plant. Both STUK and the municipality have a veto right in the licensing process

  12. Nanopatterning and nanoscale devices for biological applications

    CERN Document Server

    Šelimović, Seila

    2014-01-01

    ""This book is a good reference for researchers interested in realizing bio-applications based on micro- and nanostructures, where their interface with liquids and biomolecules is the key point. The most important 'players' of micro- and nano-bioengineering are considered, from DNA to proteins and cells. The work is a good merger of basic concepts and real examples of applications.""-Danilo Demarchi, Politecnico di Torino, Italy

  13. ITER licensing

    International Nuclear Information System (INIS)

    Gordon, C.W.

    2005-01-01

    ITER was fortunate to have four countries interested in ITER siting to the point where licensing discussions were initiated. This experience uncovered the challenges of licensing a first of a kind, fusion machine under different licensing regimes and helped prepare the way for the site specific licensing process. These initial steps in licensing ITER have allowed for refining the safety case and provide confidence that the design and safety approach will be licensable. With site-specific licensing underway, the necessary regulatory submissions have been defined and are well on the way to being completed. Of course, there is still work to be done and details to be sorted out. However, the informal international discussions to bring both the proponent and regulatory authority up to a common level of understanding have laid the foundation for a licensing process that should proceed smoothly. This paper provides observations from the perspective of the International Team. (author)

  14. Nuclear magnetic resonance applications in biological systems

    International Nuclear Information System (INIS)

    Jiang Ling; Liu Maili

    2011-01-01

    Nuclear magnetic resonance (NMR) spectroscopy is a state-of-the-art technology which has been widely applied in biological systems over the past decades. It is a powerful tool for macromolecular structure determination in solution, and has the unique advantage of being capable of elucidating the structure and dynamic behavior of proteins during vital biomedical processes. In this review, we introduce the recent progress in NMR techniques for studying the structure, interaction and dynamics of proteins. The methods for NMR based drug discovery and metabonomics are also briefly introduced. (authors)

  15. Applications of NMR in biological metabolic research

    International Nuclear Information System (INIS)

    Nie Jiarui; Li Xiuqin; He Chunjian

    1989-01-01

    The nuclear magnetic resonance has become a powerful means of studying biological metabolism in non-invasive and non-destructive way. Being used to study the metabolic processes of living system in normal physiological conditions as well as in molecular level, the method is better than other conventional approaches. Using important parameters such as NMR-chemical shifts, longitudinal relaxation time and transverse relaxation time, it is possible to probe the metabolic processes as well as conformation, concentration, transportation and distribution of reacting and resulting substances. The NMR spectroscopy of 1 H, 31 P and 13 C nuclei has already been widely used in metabolic researches

  16. Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

    Directory of Open Access Journals (Sweden)

    Ye-Rang Yun

    2010-01-01

    Full Text Available Fibroblast growth factors (FGFs that signal through FGF receptors (FGFRs regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, tooth, and nerve tissues.

  17. EPR application in medicine and biology

    Czech Academy of Sciences Publication Activity Database

    Stopka, Pavel; Křížová, Jana; Káfuňková, Eva

    2005-01-01

    Roč. 99, č. 14 (2005), s. 190-192 ISSN 0009-2770 R&D Projects: GA MZd(CZ) NB7377; GA MZd(CZ) NL7567 Institutional research plan: CEZ:AV0Z40320502 Keywords : EPR application Subject RIV: CA - Inorganic Chemistry Impact factor: 0.445, year: 2005

  18. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1983-10-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  19. Licensing topical report: application of probabilistic risk assessment in the selection of design basis accidents

    International Nuclear Information System (INIS)

    Houghton, W.J.

    1980-06-01

    A probabilistic risk assessment (PRA) approach is proposed to be used to scrutinize selection of accident sequences. A technique is described in this Licensing Topical Report to identify candidates for Design Basis Accidents (DBAs) utilizing the risk assessment results. As a part of this technique, it is proposed that events with frequencies below a specified limit would not be candidates. The use of the methodology described is supplementary to the traditional, deterministic approach and may result, in some cases, in the selection of multiple failure sequences as DBAs; it may also provide a basis for not considering some traditionally postulated events as being DBAs. A process is then described for selecting a list of DBAs based on the candidates from PRA as supplementary to knowledge and judgments from past licensing practice. These DBAs would be the events considered in Chapter 15 of Safety Analysis Reports of high-temperature gas-cooled reactors

  20. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study.

    Science.gov (United States)

    Lebov, Jill F; Engel, Lawrence S; Richardson, David; Hogan, Susan L; Hoppin, Jane A; Sandler, Dale P

    2016-01-01

    Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 39 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Via linkage to the US Renal Data System, we identified 320 ESRD cases diagnosed between enrolment (1993-1997) and December 2011 among 55 580 male licensed pesticide applicators. Participants provided information on use of pesticides via self-administered questionnaires. Lifetime pesticide use was defined as the product of duration and frequency of use and then modified by an intensity factor to account for differences in pesticide application practices. Cox proportional hazards models, adjusted for age and state, were used to estimate associations between ESRD and: (1) ordinal categories of intensity-weighted lifetime use of 39 pesticides, (2) poisoning and high-level pesticide exposures and (3) pesticide exposure resulting in a medical visit or hospitalisation. Positive exposure-response trends were observed for the herbicides alachlor, atrazine, metolachlor, paraquat, and pendimethalin, and the insecticide permethrin. More than one medical visit due to pesticide use (HR=2.13; 95% CI 1.17 to 3.89) and hospitalisation due to pesticide use (HR=3.05; 95% CI 1.67 to 5.58) were significantly associated with ESRD. Our findings support an association between ESRD and chronic exposure to specific pesticides, and suggest pesticide exposures resulting in medical visits may increase the risk of ESRD. Clinicaltrials.gov NCT00352924. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. Applications of optical manipulation in plant biology

    Science.gov (United States)

    Buer, Charles S.

    Measuring small forces in biology is important for determining basic physiological parameters of a cell. The plant cell wall provides a primary defense and presents a barrier to research. Magnitudes of small forces are impossible to measure with mechanical transducers, glass needles, atomic force microscopy, or micropipet-based force transduction due to the cell wall. Therefore, a noninvasive method of breaching the plant cell wall to access the symplastic region of the cell is required. Laser light provides sub-micrometer positioning, particle manipulation without mechanical contact, and piconewton force determination. Consequently, the extension of laser microsurgery to expand an experimental tool for plant biology encompassed the overall objective. A protocol was developed for precisely inserting microscopic objects into the periplasmic region of plant callus cells using laser microsurgery. Ginkgo biloba and Agrobacterium rhizogenes were used as the model system for developing the optical tweezers and scalpel techniques. Better than 95% survival was achieved after plasmolyzing G. biloba cells, ablating a 2-4 μm hole through the cell wall using a pulsed UV laser beam, trapping and manipulating bacteria into the periplasmic region, and deplasmolyzing the cells. Optical trapping experiments implied a difference existed between the bacteria models. Determining the optical trapping efficiency of Agrobacterium rhizogenes and A. tumefaciens strains indicated the A. rhizogenes strain, ATCC 11325, was significantly less efficiently trapped than strains A4 and ATCC 15834 and the A. tumefaciens strain LBA4404. Differences were also found in capsule generation, growth media viscosity, and transmission electron microscopy negative staining implying that a difference in surface structure exists. Calcofluor fluorescence suggests the difference involves an exopolysaccharide. Callus cell plasmolysis revealed Hechtian strands interconnecting the plasma membrane and the cell wall

  2. Parameter Selection for Department of Energy Spent Nuclear Fuel to be Used in the Yucca Mountain License Application

    Energy Technology Data Exchange (ETDEWEB)

    D. L. Fillmore

    2003-10-01

    This report contains the chemical, physical, and radiological parameters that were chosen to represent the U.S. Department of Energy spent nuclear fuel in the Yucca Mountain license application. It also contains the selected packaging requirements for the various fuel types and the criticality controls that were used. The data are reported for representative fuels and bounding fuels in groups of fuels that were selected for the analysis. The justification for the selection of each parameter is given. The data reported were not generated under any quality assurance program.

  3. Standard format and content of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    1988-01-01

    This document discusses the information that should be provided in the Safety Analysis Report and establishes a uniform format for presenting the information necessary to fulfill the licensing requirements for land disposal of radioactive waste called for in 10 CFR 61. The uniform format will (1) help ensure that the Safety Analysis Report contains the information required by 10 CFR 61, (2) aid the applicant and NRC staff in ensuring that the information is complete, (3) help persons reading the Safety Analysis Report to locate information, and (4) contribute to shortening the time needed for the review process

  4. Standard format and content of a license application for a low-level radioactive waste disposal facility: Safety analysis report

    International Nuclear Information System (INIS)

    1987-01-01

    This document discusses the information that should be provided in the Safety Analysis Report and establishes a uniform format for presenting the information necessary to fulfill the licensing requirements for land disposal of radioactive waste called for in 10 CFR 61. The uniform format will (1) help ensure that the Safety Analysis Report contains the information required by 10 CFR 61, (2) aid the applicant and NRC staff in ensuring that the information is complete, (3) help persons reading the Safety Analysis Report to locate information, and (4) contribute to shortening the time needed for the review process

  5. Preparation and application of various nanoparticles in biology and medicine

    OpenAIRE

    Vardan Gasparyan

    2013-01-01

    The present paper considers prospects for application of various nanoparticles in biology and medicine. Here are presented data on preparation of gold and silver nanoparticles, and effects of shape of these nanoparticles on their optical properties. Application of these nanoparticles in diagnostics, for drug delivery and therapy, and preparation of magnetic nanoparticles from iron and cobalt salts are also discussed. Application of these nanoparticles as magnetic resonance imaging (MRI) contr...

  6. The pre-licensing of a multi-purpose hybrid research reactor for high-tech applications 'MYRRHA'

    International Nuclear Information System (INIS)

    Hakimi, N.; Dams, C.; Wertelaers, A.; Nys, V.; Schrauben, M.; Dresselaers, R.

    2013-01-01

    The Belgian Nuclear Research Centre in Mol has been working for several years on the design of a multi-purpose flexible irradiation facility in order to replace the ageing BR2, a multipurpose materials testing reactor (MTR), in operation since 1962. MYRRHA, a flexible fast spectrum research reactor is conceived as an accelerator driven system (ADS), able to operate in sub-critical and critical modes. It contains a proton accelerator of 600 MeV, a spallation target and a multiplying medium with MOX fuel, cooled by liquid lead-bismuth (Pb-Bi). Since February 2011, the Belgian Nuclear Research Centre has engaged in a 'pre-licensing' process with the regulatory authority for an estimated period up to mid 2014. The paper presents on the one hand the objectives of the pre-licensing phase as well as its implementation process and on the other hand, 2 implementing instruments which have been developed by the regulatory authority providing guidance to the designer of MYRRHA in order to meet the pre-licensing phase objectives. The first instrument is a strategic note for the design and operation of MYRRHA where as the second instrument is a guidance document for the format and content of a design options and provisions file (DOPF). Both instruments have been developed taking into account that MYRRHA is an irradiation facility using a Generation IV nuclear power system's type technology (liquid metal cooled fast neutron reactor). The strategic note overview aims to cover the safety approach as well as the security requirements and safeguards obligation applicable to MYRRHA. In particular, in the strategic note, a specific attention has been paid in order to ensure that a safety, security and safeguards integrated approach will drive the development of the MYRRHA design. The safety approach focuses on the safety goals and the minimum safety objectives set by the regulatory authority for this innovative design. The DOPF overview presents its objectives and structure resuming

  7. Biologically active extracts with kidney affections applications

    Science.gov (United States)

    Pascu (Neagu), Mihaela; Pascu, Daniela-Elena; Cozea, Andreea; Bunaciu, Andrei A.; Miron, Alexandra Raluca; Nechifor, Cristina Aurelia

    2015-12-01

    This paper is aimed to select plant materials rich in bioflavonoid compounds, made from herbs known for their application performances in the prevention and therapy of renal diseases, namely kidney stones and urinary infections (renal lithiasis, nephritis, urethritis, cystitis, etc.). This paper presents a comparative study of the medicinal plant extracts composition belonging to Ericaceae-Cranberry (fruit and leaves) - Vaccinium vitis-idaea L. and Bilberry (fruit) - Vaccinium myrtillus L. Concentrated extracts obtained from medicinal plants used in this work were analyzed from structural, morphological and compositional points of view using different techniques: chromatographic methods (HPLC), scanning electronic microscopy, infrared, and UV spectrophotometry, also by using kinetic model. Liquid chromatography was able to identify the specific compounds of the Ericaceae family, present in all three extracts, arbutosid, as well as specific components of each species, mostly from the class of polyphenols. The identification and quantitative determination of the active ingredients from these extracts can give information related to their therapeutic effects.

  8. [Biological characteristics of calliphoridae and its application in forensic medicine].

    Science.gov (United States)

    Zhao, Boa; Wen, Charn; Qi, Li-Li; Wang, He; Wang, Ji

    2013-12-01

    Diptera Calliphoridae is the first major kind of flies that appears on the decomposed corpses. In forensic entomology, according to the living characteristics of Calliphoridae flies, we could accurately estimate postmortem interval (PMI) in a murder or unidentified case and could provide useful clues to solve the case. This paper introduces the characteristics of the biology and morphology of Diptera Calliphoridae, and reviews the combined application of forensic entomology, molecular biology, mathematical morphology and toxicology.

  9. License renewal process

    International Nuclear Information System (INIS)

    Fable, D.; Prah, M.; Vrankic, K.; Lebegner, J.

    2004-01-01

    The purpose of this paper is to provide information about license renewal process, as defined by Nuclear Regulatory Commission (NRC). The Atomic Energy Act and NRC regulations limit commercial power reactor licenses to an initial 40 years but also permit such licenses to be renewed. This original 40-year term for reactor licenses was based on economic and antitrust considerations not on limitations of nuclear technology. Due to this selected time period; however, some structures and components may have been engineered on the basis of an expected 40-year service life. The NRC has established a timely license renewal process and clear requirements codified in 10 CFR Part 51 and 10 CFR Part 54, that are needed to assure safe plant operation for extended plant life. The timely renewal of licenses for an additional 20 years, where appropriate to renew them, may be important to ensuring an adequate energy supply during the first half of the 21st Century. License renewal rests on the determination that currently operating plants continue to maintain adequate levels of safety, and over the plant's life, this level has been enhanced through maintenance of the licensing bases, with appropriate adjustments to address new information from industry operating experience. Additionally, NRC activities have provided ongoing assurance that the licensing bases will continue to provide an acceptable level of safety. This paper provides additional discussion of license renewal costs, as one of key elements in evaluation of license renewal justifiability. Including structure of costs, approximately value and two different approaches, conservative and typical. Current status and position of Nuclear Power Plant Krsko, related to license renewal process, will be briefly presented in this paper. NPP Krsko is designed based on NRC Regulations, so requirements from 10 CFR 51, and 10 CFR 54, are applicable to NPP Krsko, as well. Finally, this paper will give an overview of current status of

  10. Recent applications of synthetic biology tools for yeast metabolic engineering

    DEFF Research Database (Denmark)

    Jensen, Michael Krogh; Keasling, Jay

    2015-01-01

    to engineer microbial chemical factories has steadily decreased, improvement is still needed. Through the development of synthetic biology tools for key microbial hosts, it should be possible to further decrease the development times and improve the reliability of the resulting microorganism. Together...... with continuous decreases in price and improvements in DNA synthesis, assembly and sequencing, synthetic biology tools will rationalize time-consuming strain engineering, improve control of metabolic fluxes, and diversify screening assays for cellular metabolism. This review outlines some recently developed...... synthetic biology tools and their application to improve production of chemicals and fuels in yeast. Finally, we provide a perspective for the challenges that lie ahead....

  11. Biological applications of ultraviolet free-electron lasers

    International Nuclear Information System (INIS)

    Sutherland, J.C.

    1997-10-01

    This review examines the possibilities for biological research using the three ultraviolet free-electron lasers that are nearing operational status in the US. The projected operating characteristics of major interest in biological research of the free-electron lasers at Brookhaven National Laboratory, the Thomas Jefferson National Accelerator Facility, and Duke University are presented. Experimental applications in the areas of far- and vacuum ultraviolet photophysics and photochemistry, structural biology, environmental photobiology, and medical research are discussed and the prospects for advances in these areas, based upon the characteristics of the new ultraviolet free-electron lasers, are evaluated

  12. Applications of dynamical systems in biology and medicine

    CERN Document Server

    Radunskaya, Ami

    2015-01-01

    This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control.  Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction.  Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation. .

  13. Nuclear plant license renewal

    International Nuclear Information System (INIS)

    Gazda, P.A.; Bhatt, P.C.

    1991-01-01

    During the next 10 years, nuclear plant license renewal is expected to become a significant issue. Recent Electric Power Research Institute (EPRI) studies have shown license renewal to be technically and economically feasible. Filing an application for license renewal with the Nuclear Regulatory Commission (NRC) entails verifying that the systems, structures, and components essential for safety will continue to perform their safety functions throughout the license renewal period. This paper discusses the current proposed requirements for this verification and the current industry knowledge regarding age-related degradation of structures. Elements of a license renewal program incorporating NRC requirements and industry knowledge including a schedule are presented. Degradation mechanisms for structural components, their significance to nuclear plant structures, and industry-suggested age-related degradation management options are also reviewed

  14. License renewal

    International Nuclear Information System (INIS)

    Newberry, S.

    1993-01-01

    This article gives an overview of the process of license renewal for nuclear power plants. It explains what is meant by license renewal, the significance of license renewal, and goes over key elements involved in the process of license renewal. Those key elements are NRC requirements embodied in 10 CFR Part 54 (Reactor Safety) and 10 CFR Part 51 (Environmental Issues). In addition Industry Reports must be developed and reviewed. License renewal is essentially the process of applying for a 20 year extension to the original 40 year operating license granted for the plant. This is a very long term process, which involves a lot of preparation, and compliance with regulatory rules and guidelines. In general it is a process which is expected to begin when plants reach an operating lifetime of 20 years. It has provisions for allowing the public to become involved in the review process

  15. Biologically active extracts with kidney affections applications

    International Nuclear Information System (INIS)

    Pascu, Mihaela; Pascu, Daniela-Elena; Cozea, Andreea; Bunaciu, Andrei A.; Miron, Alexandra Raluca; Nechifor, Cristina Aurelia

    2015-01-01

    Highlights: • The paper highlighted the compositional similarities and differences between the three extracts of bilberry and cranberry fruit derived from the same Ericaceae family. • A method of antioxidant activity, different cellulose membranes, a Whatman filter and Langmuir – kinetic model were used. • Arbutoside presence in all three extracts of bilberry and cranberry fruit explains their use in urinary infections – cystitis and colibacillosis. • Following these research studies, it was established that the fruits of bilberry and cranberry (fruit and leaves) significantly reduce the risk of urinary infections, and work effectively to protect against free radicals and inflammation. - Abstract: This paper is aimed to select plant materials rich in bioflavonoid compounds, made from herbs known for their application performances in the prevention and therapy of renal diseases, namely kidney stones and urinary infections (renal lithiasis, nephritis, urethritis, cystitis, etc.). This paper presents a comparative study of the medicinal plant extracts composition belonging to Ericaceae-Cranberry (fruit and leaves) – Vaccinium vitis-idaea L. and Bilberry (fruit) – Vaccinium myrtillus L. Concentrated extracts obtained from medicinal plants used in this work were analyzed from structural, morphological and compositional points of view using different techniques: chromatographic methods (HPLC), scanning electronic microscopy, infrared, and UV spectrophotometry, also by using kinetic model. Liquid chromatography was able to identify the specific compounds of the Ericaceae family, present in all three extracts, arbutosid, as well as specific components of each species, mostly from the class of polyphenols. The identification and quantitative determination of the active ingredients from these extracts can give information related to their therapeutic effects.

  16. Biologically active extracts with kidney affections applications

    Energy Technology Data Exchange (ETDEWEB)

    Pascu, Mihaela, E-mail: mihhaela_neagu@yahoo.com [SC HOFIGAL S.A., Analytical Research Department, 2 Intr. Serelor, Bucharest-4 042124 (Romania); Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-5 Polizu Street, 11061 Bucharest (Romania); Pascu, Daniela-Elena [Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-5 Polizu Street, 11061 Bucharest (Romania); Cozea, Andreea [SC HOFIGAL S.A., Analytical Research Department, 2 Intr. Serelor, Bucharest-4 042124 (Romania); Transilvania University of Brasov, Faculty of Food and Tourism, 148 Castle Street, 500036 Brasov (Romania); Bunaciu, Andrei A. [SCIENT – Research Center for Instrumental Analysis, S.C. CROMATEC-PLUS S.R.L., 18 Sos. Cotroceni, Bucharest 060114 (Romania); Miron, Alexandra Raluca; Nechifor, Cristina Aurelia [Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-5 Polizu Street, 11061 Bucharest (Romania)

    2015-12-15

    Highlights: • The paper highlighted the compositional similarities and differences between the three extracts of bilberry and cranberry fruit derived from the same Ericaceae family. • A method of antioxidant activity, different cellulose membranes, a Whatman filter and Langmuir – kinetic model were used. • Arbutoside presence in all three extracts of bilberry and cranberry fruit explains their use in urinary infections – cystitis and colibacillosis. • Following these research studies, it was established that the fruits of bilberry and cranberry (fruit and leaves) significantly reduce the risk of urinary infections, and work effectively to protect against free radicals and inflammation. - Abstract: This paper is aimed to select plant materials rich in bioflavonoid compounds, made from herbs known for their application performances in the prevention and therapy of renal diseases, namely kidney stones and urinary infections (renal lithiasis, nephritis, urethritis, cystitis, etc.). This paper presents a comparative study of the medicinal plant extracts composition belonging to Ericaceae-Cranberry (fruit and leaves) – Vaccinium vitis-idaea L. and Bilberry (fruit) – Vaccinium myrtillus L. Concentrated extracts obtained from medicinal plants used in this work were analyzed from structural, morphological and compositional points of view using different techniques: chromatographic methods (HPLC), scanning electronic microscopy, infrared, and UV spectrophotometry, also by using kinetic model. Liquid chromatography was able to identify the specific compounds of the Ericaceae family, present in all three extracts, arbutosid, as well as specific components of each species, mostly from the class of polyphenols. The identification and quantitative determination of the active ingredients from these extracts can give information related to their therapeutic effects.

  17. Development and application of a deterministic-realistic hybrid methodology for LOCA licensing analysis

    International Nuclear Information System (INIS)

    Liang, Thomas K.S.; Chou, Ling-Yao; Zhang, Zhongwei; Hsueh, Hsiang-Yu; Lee, Min

    2011-01-01

    Highlights: → A new LOCA licensing methodology (DRHM, deterministic-realistic hybrid methodology) was developed. → DRHM involves conservative Appendix K physical models and statistical treatment of plant status uncertainties. → DRHM can generate 50-100 K PCT margin as compared to a traditional Appendix K methodology. - Abstract: It is well recognized that a realistic LOCA analysis with uncertainty quantification can generate greater safety margin as compared with classical conservative LOCA analysis using Appendix K evaluation models. The associated margin can be more than 200 K. To quantify uncertainty in BELOCA analysis, generally there are two kinds of uncertainties required to be identified and quantified, which involve model uncertainties and plant status uncertainties. Particularly, it will take huge effort to systematically quantify individual model uncertainty of a best estimate LOCA code, such as RELAP5 and TRAC. Instead of applying a full ranged BELOCA methodology to cover both model and plant status uncertainties, a deterministic-realistic hybrid methodology (DRHM) was developed to support LOCA licensing analysis. Regarding the DRHM methodology, Appendix K deterministic evaluation models are adopted to ensure model conservatism, while CSAU methodology is applied to quantify the effect of plant status uncertainty on PCT calculation. Generally, DRHM methodology can generate about 80-100 K margin on PCT as compared to Appendix K bounding state LOCA analysis.

  18. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Science.gov (United States)

    2010-04-01

    ... forth the medical rational and purpose (or lack thereof) for the biological product and its components... directions for use and warnings against unsafe use, provides rational concurrent preventive therapy or... become effective as specified in the order. (h) [Reserved] (i) Court Appeal. The final order(s) published...

  19. Flow cytometric applications of tumor biology: prospects and pitfalls

    International Nuclear Information System (INIS)

    Raju, M.R.; Johnson, T.S.; Tokita, N.; Gillette, E.L.

    1979-01-01

    A brief review of cytometry instrumentation and its potential applications in tumor biology is presented using our recent data. Age-distribution measurements of cells from spontaneous dog tumors and cultured cells after exposure to x rays, alpha particles, or adriamycin are shown. The data show that DNA fluorescence measurements have application in the study of cell kinetics after either radiation or drug treatment. Extensive and careful experimentation is needed to utilize the sophisticated developments in flow cytometry instrumentation

  20. Flow cytometric applications to tumour biology: prospects and pitfalls

    International Nuclear Information System (INIS)

    Raju, M.R.; Johnson, T.S.; Tokita, N.; Gillette, E.L.

    1980-01-01

    A brief review of cytometry instrumentation and its potential applications in tumour biology is presented. DNA distribution measurements of cells from spontaneous dog tumours and cultured cells after exposure to X-rays, alpha particles or adriamycin are shown. The data show that DNA fluorescence measurements have application in the study of cell kinetics after either radiation or drug treatment. Extensive and careful experimentation is needed, however, to utilize the sophisticated developments in flow cytometry instrumentation. (author)

  1. Cellular potts models multiscale extensions and biological applications

    CERN Document Server

    Scianna, Marco

    2013-01-01

    A flexible, cell-level, and lattice-based technique, the cellular Potts model accurately describes the phenomenological mechanisms involved in many biological processes. Cellular Potts Models: Multiscale Extensions and Biological Applications gives an interdisciplinary, accessible treatment of these models, from the original methodologies to the latest developments. The book first explains the biophysical bases, main merits, and limitations of the cellular Potts model. It then proposes several innovative extensions, focusing on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description. Through several biological examples, the authors demonstrate a qualitative and quantitative agreement with t...

  2. Contestable Licensing

    OpenAIRE

    Zvika Neeman; Gerhard O. Orosel

    2000-01-01

    We analyze a model of repeated franchise bidding for natural monopoly with contestable licensing - a franchisee halds an (exclusive) license to operate a franchise until another rm offers to pay more for it. In a world where quality is observable but not veri able, the simple regulatory scheme we describe combines market-like incentives with regulatory oversight to generate efficient outcomes.

  3. Radiopharmaceutical licensing

    International Nuclear Information System (INIS)

    Mather, S.J.

    1992-01-01

    Recent health service legislation, and especially the loss of crown immunity has once again focussed attention on the arrangements for licensing of radiopharmaceuticals. The aim of the article is to describe in general terms the UK licensing system and in particular to provide guidance to those responsible for the supply of radiopharmaceuticals in hospitals. (author)

  4. Reactor licensing

    International Nuclear Information System (INIS)

    Harvie, J.D.

    2002-01-01

    This presentation discusses reactor licensing and includes the legislative basis for licensing, other relevant legislation , the purpose of the Nuclear Safety and Control Act, important regulations, regulatory document, policies, and standards. It also discusses the role of the CNSC, its mandate and safety philosophy

  5. Some Issues of Biological Shape Modelling with Applications

    DEFF Research Database (Denmark)

    Larsen, Rasmus; Hilger, Klaus Baggesen; Skoglund, Karl

    2003-01-01

    This paper illustrates current research at Informatics and Mathematical Modelling at the Technical University of Denmark within biological shape modelling. We illustrate a series of generalizations to, modifications to, and applications of the elements of constructing models of shape or appearance...

  6. Design of Functional Polyesters for Electronic and Biological Applications

    OpenAIRE

    Nelson, Ashley Marie

    2015-01-01

    Melt polymerization and novel monomers enabled the synthesis of polyesters for electronic and biological applications. Inspiration from nature and a passion for environmental preservation instigated an emphasis on the incorporation of renewable resources into polymeric materials. Critical analysis of current research surrounding bisphenol-A replacements and ioncontaining segmented polyurethanes aided in identifying benchmark polymers, including limitations, challenges, and future needs. Struc...

  7. Differential scanning calorimetry techniques: applications in biology and nanoscience.

    Science.gov (United States)

    Gill, Pooria; Moghadam, Tahereh Tohidi; Ranjbar, Bijan

    2010-12-01

    This paper reviews the best-known differential scanning calorimetries (DSCs), such as conventional DSC, microelectromechanical systems-DSC, infrared-heated DSC, modulated-temperature DSC, gas flow-modulated DSC, parallel-nano DSC, pressure perturbation calorimetry, self-reference DSC, and high-performance DSC. Also, we describe here the most extensive applications of DSC in biology and nanoscience.

  8. Differential Scanning Calorimetry Techniques: Applications in Biology and Nanoscience

    OpenAIRE

    Gill, Pooria; Moghadam, Tahereh Tohidi; Ranjbar, Bijan

    2010-01-01

    This paper reviews the best-known differential scanning calorimetries (DSCs), such as conventional DSC, microelectromechanical systems-DSC, infrared-heated DSC, modulated-temperature DSC, gas flow-modulated DSC, parallel-nano DSC, pressure perturbation calorimetry, self-reference DSC, and high-performance DSC. Also, we describe here the most extensive applications of DSC in biology and nanoscience.

  9. Preparing as an organization, to submit or to review a construction license application for a DGR of ILW and HLW in France. French National Case - Andra - Preparing to Submit Cigeo's Creation License Application

    International Nuclear Information System (INIS)

    Boissier, Fabrice; Labalette, T.; Leverd, Pascal C.; Voinis, Sylvie

    2014-01-01

    The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste. Since the first French Act on nuclear waste management research (1991), Andra has carried out twenty years of conceptual and basic studies on the subject, leading in particular to the feasibility demonstration in 2005 and to the choice of the detailed reconnaissance zone (ZIRA) in 2010. Taking advantage from this work, Andra has now reached a new phase where the project is engaging in the design of the industrial installation named Cigeo. At this stage, the further development of the project implies that Andra undertakes a multiplicity of actions in order to successfully reach various external and internal key milestones. Of paramount importance is the careful articulation between the regulatory authorization and decision processes and the outcome of the industrial installation design phases. In 2006 was built a regulatory framework that plans a succession of step by step decisions stages: 2013: Public debate on reversibility, memory keeping, environmental and health survey modalities, dialogue with the local stakeholders to harmoniously define and plan the external infrastructures that have to be developed to support the construction and the operation of Cigeo (roads, railway tracks and terminal, power and water supplies, etc.). 2015: Creation license application and start of the regulatory review process (notably various plans of the installation, the description of the solution envisaged for the closure of the facility, the preliminary safety case (operational safety, long-term safety, protection against malevolent actions, management of incidental situations, preliminary acceptance criteria), environmental impact studies (health, salubrity, transports, human activities, nature, patrimonial aspects). 2016-2017: new parliamentary Act on the reversibility conditions of the

  10. Vignettes from the field of mathematical biology: the application of mathematics to biology and medicine.

    Science.gov (United States)

    Murray, J D

    2012-08-06

    The application of mathematical models in biology and medicine has a long history. From the sparse number of papers in the first half of the twentieth century with a few scientists working in the field it has become vast with thousands of active researchers. We give a brief, and far from definitive history, of how some parts of the field have developed and how the type of research has changed. We describe in more detail just two examples of specific models which are directly related to real biological problems, namely animal coat patterns and the growth and image enhancement of glioblastoma brain tumours.

  11. Yeast synthetic biology toolbox and applications for biofuel production.

    Science.gov (United States)

    Tsai, Ching-Sung; Kwak, Suryang; Turner, Timothy L; Jin, Yong-Su

    2015-02-01

    Yeasts are efficient biofuel producers with numerous advantages outcompeting bacterial counterparts. While most synthetic biology tools have been developed and customized for bacteria especially for Escherichia coli, yeast synthetic biological tools have been exploited for improving yeast to produce fuels and chemicals from renewable biomass. Here we review the current status of synthetic biological tools and their applications for biofuel production, focusing on the model strain Saccharomyces cerevisiae We describe assembly techniques that have been developed for constructing genes, pathways, and genomes in yeast. Moreover, we discuss synthetic parts for allowing precise control of gene expression at both transcriptional and translational levels. Applications of these synthetic biological approaches have led to identification of effective gene targets that are responsible for desirable traits, such as cellulosic sugar utilization, advanced biofuel production, and enhanced tolerance against toxic products for biofuel production from renewable biomass. Although an array of synthetic biology tools and devices are available, we observed some gaps existing in tool development to achieve industrial utilization. Looking forward, future tool development should focus on industrial cultivation conditions utilizing industrial strains. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

  12. Workshop on High-Field NMR and Biological Applications

    Science.gov (United States)

    Scientists at the Pacific Northwest Laboratory have been working toward the establishment of a new Molecular Science Research Center (MSRC). The primary scientific thrust of this new research center is in the areas of theoretical chemistry, chemical dynamics, surface and interfacial science, and studies on the structure and interactions of biological macromolecules. The MSRC will provide important new capabilities for studies on the structure of biological macromolecules. The MSRC program includes several types of advanced spectroscopic techniques for molecular structure analysis, and a theory and modeling laboratory for molecular mechanics/dynamics calculations and graphics. It is the goal to closely integrate experimental and theoretical studies on macromolecular structure, and to join these research efforts with those of the molecular biological programs to provide new insights into the structure/function relationships of biological macromolecules. One of the areas of structural biology on which initial efforts in the MSRC will be focused is the application of high field, 2-D NMR to the study of biological macromolecules. First, there is interest in obtaining 3-D structural information on large proteins and oligonucleotides. Second, one of the primary objectives is to closely link theoretical approaches to molecular structure analysis with the results obtained in experimental research using NMR and other spectroscopies.

  13. 22 CFR 96.30 - State licensing.

    Science.gov (United States)

    2010-04-01

    ... Licensing and Corporate Governance § 96.30 State licensing. (a) The agency or person is properly licensed or... person follows applicable State licensing and regulatory requirements in all jurisdictions in which it provides adoption services. (c) If it provides adoption services in a State in which it is not itself...

  14. Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility

    International Nuclear Information System (INIS)

    1994-04-01

    The Standard Review Plan (SRP) (NUREG-1200) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform safety reviews of applications to construct and operate low-level radioactive waste disposal facilities. The SRP ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate proposed changes in the scope and requirements of the staff reviews. The SRP makes information about the regulatory licensing process widely available and serves to improve the understanding of the staff's review process by interested members of the public and the industry. Each individual SRP addresses the responsibilities of persons performing the review, the matters that are reviewed, the Commission's regulations and acceptance criteria necessary for the review, how the review is accomplished, the conclusions that are appropriate, and the implementation requirements

  15. Issues in the review of a license application for an above grade low-level radioactive waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Ringenberg, J.D. [Nebraska Dept. of Environmental Quality, NE (United States)

    1993-03-01

    In December 1987, Nebraska was selected by the Central Interstate Compact (CIC) Commission as the host state for the construction of a low-level radioactive waste disposal facility. After spending a year in the site screening process, the Compact`s developer, US Ecology, selected three sites for detailed site characterization. These sites were located in Nemaha, Nuckolls and Boyd Counties. One year later the Boyd County site was selected as the preferred site and additional site characterization studies were undertaken. On July 29, 1990, US Ecology submitted a license application to the Nebraska Department of Environmental Control (now Department of Environmental Quality-NDEQ). This paper will present issues that the NDEQ has dealt with since Nebraska`s selection as the host state for the CIC facility.

  16. Mobile-based biology edutainment application for secondary schools

    Science.gov (United States)

    AL-Modwahi, Ashraf Abbas M.; Kaisara, Onalenna; Parkizkar, Behrang; Habibi Lashkari, Arash

    2013-03-01

    The high increase of mobile technology is leading to mobilized learning environment, thus making traditional learning to diminish slowly and become inactive and unproductive. Learners worldwide are being attracted to mobile environment more so that it promotes anytime, anywhere learning. Biology as a secondary school subject will be applicable for mobile learning for such a time and generation as this. This paper is therefore an attempt to mobile based biology edutainment system for the students who normally range from the ages of thirteen to sixteen.

  17. An introduction to stochastic processes with applications to biology

    CERN Document Server

    Allen, Linda J S

    2010-01-01

    An Introduction to Stochastic Processes with Applications to Biology, Second Edition presents the basic theory of stochastic processes necessary in understanding and applying stochastic methods to biological problems in areas such as population growth and extinction, drug kinetics, two-species competition and predation, the spread of epidemics, and the genetics of inbreeding. Because of their rich structure, the text focuses on discrete and continuous time Markov chains and continuous time and state Markov processes.New to the Second EditionA new chapter on stochastic differential equations th

  18. Application of PLUTO Test Facility for U. S. NRC Licensing of a Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dongseok; Shin, Changhwan; Lee, Kanghee; Kang, Heungseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    The fuel assembly of the PLUS-7 loaded in the APR-1400 follows the same schedule. Meanwhile, In July 1998, the U.S. NRC adopted a research plan to address the effects of high burnup from a Loss of Coolant Accident (LOCA). From these programs, several important technical findings for rule revision were obtained. Based on the technical findings, the U. S. NRC has amended the 10 CFR 50.46 which will be proclaimed sooner or later. Through the amendment, a LOCA analysis on the fuel assembly has to show the safety at both a fresh and End of Life (EOL) state. The U. S. NRC has already required EOL effects on seismic/LOCA performance for a fuel assembly since 1998. To obtain U.S NRC licensing of a fuel assembly, based on the amendment of 10CFR50.46, a LOCA analysis of the fuel assembly has to show safety both fresh and EOL states. The proper damping factor of the fuel assembly measured at the hydraulic test loop for a dynamic model in a LOCA and a seismic analysis code are at least required. In this paper, we have examined the damping technologies and compared the test facility of PLUTO with others in terms of performance. PLUTO has a better performance on the operating conditions than any others.

  19. Dealing with the current permissibility application for constructing a spent fuel DGR in Sweden. SKB's license applications for a spent fuel repository

    International Nuclear Information System (INIS)

    Olsson, Olle

    2014-01-01

    The nuclear power utilities in Sweden were in 1976 obliged to demonstrate a safe method for final disposal of spent fuel in order to start operation of new reactors. This initiated a comprehensive research, development and demonstration programme and the development of the KBS-method for final disposal. A new Nuclear Activities Act in 1984 gave the reactor owners full technical and financial responsibility for the waste. They gave in turn SKB the responsibility for all nuclear waste management. Reprocessing was no longer required and direct disposal of the spent fuel has, since then, been the main alternative. Alternative methods for final disposal have been evaluated and compared to the KBS-3-method but it has remained the preferred alternative. A comprehensive research, development and demonstration programme to strengthen the scientific basis and to refine the KBS-3-method has been operated by SKB since then. The site selection process for the final repository for spent nuclear fuel was initiated in 1992. The work included general siting studies at the national and the municipal level and in 2002, SKB initiated site investigations for siting of a final repository on two sites: the Simpevarp and Laxemar areas and the Forsmark area. At the same time, the work on preparing license applications to construct and operate an encapsulation plant and a final repository for spent fuel was started. In June 2009, SKB announced Forsmark as the selected site for the final repository. This paper reviews the applicable legislation and describes the license application, the licensing review and the preparations for implementation

  20. Ordinary differential equations with applications in molecular biology.

    Science.gov (United States)

    Ilea, M; Turnea, M; Rotariu, M

    2012-01-01

    Differential equations are of basic importance in molecular biology mathematics because many biological laws and relations appear mathematically in the form of a differential equation. In this article we presented some applications of mathematical models represented by ordinary differential equations in molecular biology. The vast majority of quantitative models in cell and molecular biology are formulated in terms of ordinary differential equations for the time evolution of concentrations of molecular species. Assuming that the diffusion in the cell is high enough to make the spatial distribution of molecules homogenous, these equations describe systems with many participating molecules of each kind. We propose an original mathematical model with small parameter for biological phospholipid pathway. All the equations system includes small parameter epsilon. The smallness of epsilon is relative to the size of the solution domain. If we reduce the size of the solution region the same small epsilon will result in a different condition number. It is clear that the solution for a smaller region is less difficult. We introduce the mathematical technique known as boundary function method for singular perturbation system. In this system, the small parameter is an asymptotic variable, different from the independent variable. In general, the solutions of such equations exhibit multiscale phenomena. Singularly perturbed problems form a special class of problems containing a small parameter which may tend to zero. Many molecular biology processes can be quantitatively characterized by ordinary differential equations. Mathematical cell biology is a very active and fast growing interdisciplinary area in which mathematical concepts, techniques, and models are applied to a variety of problems in developmental medicine and bioengineering. Among the different modeling approaches, ordinary differential equations (ODE) are particularly important and have led to significant advances

  1. Fundamentals and applications of neutron imaging. Application part 9. Application of neutron imaging to biological research

    International Nuclear Information System (INIS)

    Kawabata, Yuji

    2007-01-01

    For radiography, the use of neutrons as a complement to X-rays is especially suitable for biological research such as plant, wood, and medical application due to the enhanced sensitivity to light elements such as hydrogen, carbon, and nitrogen. The present paper introduces applications of neutron CT to the humidity (water) distribution and its variation in the flowering plant as cut carnation, observation of water movement in refrigerated chrysanthemum leaves using very cold neutron and in cut leaves using deuterium oxide and ordinary water, measurement of water movement in sprouting cone and soy bean and growing ginseng in the soil, and other applications as to archaeological wood immersed in a restoration solution and to medical purposes. (S. Ohno)

  2. [Application of network biology on study of traditional Chinese medicine].

    Science.gov (United States)

    Tian, Sai-Sai; Yang, Jian; Zhao, Jing; Zhang, Wei-Dong

    2018-01-01

    With the completion of the human genome project, people have gradually recognized that the functions of the biological system are fulfilled through network-type interaction between genes, proteins and small molecules, while complex diseases are caused by the imbalance of biological processes due to a number of gene expression disorders. These have contributed to the rise of the concept of the "multi-target" drug discovery. Treatment and diagnosis of traditional Chinese medicine are based on holism and syndrome differentiation. At the molecular level, traditional Chinese medicine is characterized by multi-component and multi-target prescriptions, which is expected to provide a reference for the development of multi-target drugs. This paper reviews the application of network biology in traditional Chinese medicine in six aspects, in expectation to provide a reference to the modernized study of traditional Chinese medicine. Copyright© by the Chinese Pharmaceutical Association.

  3. 78 FR 29391 - Luminant Generation Company, LLC; Combined License Application for Comanche Peak Nuclear Power...

    Science.gov (United States)

    2013-05-20

    ... only temporary relief from the applicable regulation and the licensee has made good faith efforts to... only temporary relief from the regulations of 10 CFR 50.71(e)(3)(iii). Luminant has made good faith... applicable regulation and the licensee has made good faith efforts to comply with the regulation'' (10 CFR 50...

  4. 78 FR 36014 - Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-14

    ... timeline for processing an application. When MarAd and USCG determine that an application contains the... that Port Ambrose falls within the proposed area of interest for the New York Power Authority Long Island-New York City Offshore Wind Project. This project will be acknowledged and considered in the...

  5. 75 FR 32450 - Idaho Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2010-06-08

    .... Name of Project: C.J. Strike Hydroelectric Project. f. Location: The project is located on the Snake... Snake River. l. Locations of the Application: A copy of the application is available for inspection and reproduction at the Commission's Public Reference Room, located at 888 First Street, NE., Room 2A, Washington...

  6. 75 FR 57266 - Idaho Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2010-09-20

    ...) is located on the Snake River in Gooding, Twin Falls and Elmore Counties, Idaho. The Lower Salmon Falls Project (P-2061) is located on the Snake River in Gooding and Twin Falls Counties, Idaho. Both.... Locations of the Application: A copy of the application is available for inspection and reproduction at the...

  7. Advances in Structural Biology and the Application to Biological Filament Systems.

    Science.gov (United States)

    Popp, David; Koh, Fujiet; Scipion, Clement P M; Ghoshdastider, Umesh; Narita, Akihiro; Holmes, Kenneth C; Robinson, Robert C

    2018-04-01

    Structural biology has experienced several transformative technological advances in recent years. These include: development of extremely bright X-ray sources (microfocus synchrotron beamlines and free electron lasers) and the use of electrons to extend protein crystallography to ever decreasing crystal sizes; and an increase in the resolution attainable by cryo-electron microscopy. Here we discuss the use of these techniques in general terms and highlight their application for biological filament systems, an area that is severely underrepresented in atomic resolution structures. We assemble a model of a capped tropomyosin-actin minifilament to demonstrate the utility of combining structures determined by different techniques. Finally, we survey the methods that attempt to transform high resolution structural biology into more physiological environments, such as the cell. Together these techniques promise a compelling decade for structural biology and, more importantly, they will provide exciting discoveries in understanding the designs and purposes of biological machines. © 2018 The Authors. BioEssays Published by WILEY Periodicals, Inc.

  8. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1994-06-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  9. Biological isotopy. Introduction to the isotopic effects and to their applications in biology

    International Nuclear Information System (INIS)

    Tcherkez, G.

    2010-01-01

    Since their discovery in the beginning of the 20. century, the study of stable isotopes has considerably developed. This domain, which remained limited in its applications until the 1990's, has become particularly important thereafter thanks to its practical applications and in particular to its economical impacts. Many techniques used in fraud control, in drugs use control, in selection of high-yield plants etc are based on isotopic abundance measurements. This reference book gives a synthesis of our actual knowledge on the use of stable isotopes and of isotope fractionation in biology. It presents the basic notions of isotopic biochemistry and explains the origin of the isotopic effects. The application principles of these effects to metabolism, to organisms physiology, to environmental biology etc are explained and detailed using examples and exercises. The first chapters present the basic knowledge which defines, from a mathematical point-of-view, the isotopic effects of chemical reactions or of physical processes taking place in biology. The measurements principle of natural isotopes abundance is then synthesised. Finally, all these notions are applied at different scales: enzymes, physiology, metabolism, environment, ecosystems and fraud crackdown. (J.S.)

  10. Transcription control engineering and applications in synthetic biology

    Directory of Open Access Journals (Sweden)

    Michael D. Engstrom

    2017-09-01

    Full Text Available In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein, a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators (cis-factors were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators (trans-factors, giving examples of how cis- and trans-acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli, we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

  11. Transcription control engineering and applications in synthetic biology.

    Science.gov (United States)

    Engstrom, Michael D; Pfleger, Brian F

    2017-09-01

    In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein), a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity) levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators ( cis -factors) were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators ( trans- factors), giving examples of how cis- and trans -acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli , we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

  12. Applications of Free Electron Lasers in Biology and Medicine

    International Nuclear Information System (INIS)

    Pelka, J.B.; Tybor, K.R.; Nietubyc, R.; Wrochna, G.

    2010-01-01

    The advent of free electron lasers opens up new opportunities to probe the dynamics of ultrafast processes and the structure of matter with unprecedented spatial and temporal resolution. New methods inaccessible with other known types of radiation sources can be developed, resulting in a breakthrough in deep understanding the fundamentals of life as well as in numerous medical and biological applications. In the present work the properties of free electron laser radiation that make the sources excellent for probing biological matter at an arbitrary wavelength, in a wide range of intensities and pulse durations are briefly discussed. A number of biophysical and biomedical applications of the new sources, currently considered among the most promising in the field, are presented. (author)

  13. Review of neutron radiographic applications in industrial and biological systems

    International Nuclear Information System (INIS)

    Ashraf, M.M.; Khan, A.R.

    1992-10-01

    Neutron radiography is a non-destructive testing technique and is being used worldwide for the design and the development of reactor fuels for research and power reactors. It is also being used for non-destructive examination of nuclear industrial products. In addition to its explosives and other industrial sectors. In addition to its applications in industrial sectors, the technique is widely used for research and development activities in biological systems. A review of technical applications of neutron radiography in different fields particularly in nuclear fuel management, aerospace industry, explosives and biology is presented. The methodology of neutron radiography is also discussed in detail along with the advantages of the technique. In addition, the potential of the neutron radiography facility at PINSTECH has been described. (author)

  14. Micro and nanotechnology for biological and biomedical applications.

    Science.gov (United States)

    Lim, Chwee Teck; Han, Jongyoon; Guck, Jochen; Espinosa, Horacio

    2010-10-01

    This special issue contains some of the current state-of-the-art development and use of micro and nanotechnological tools, devices and techniques for both biological and biomedical research and applications. These include nanoparticles for bioimaging and biosensing, optical and biophotonic techniques for probing diseases at the nanoscale, micro and nano-fabricated tools for elucidating molecular mechanisms of mechanotransduction in cell and molecular biology and cell separation microdevices and techniques for isolating and enriching targeted cells for disease detection and diagnosis. Although some of these works are still at the research stage, there is no doubt that some of the important outcomes will eventually see actual biomedical applications in the not too distant future.

  15. Research Applications of Proteolytic Enzymes in Molecular Biology

    Directory of Open Access Journals (Sweden)

    József Tőzsér

    2013-11-01

    Full Text Available Proteolytic enzymes (also termed peptidases, proteases and proteinases are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications require their use, including production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, cell culturing and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics and therapy, exploration of the structure-function relationships by structural studies, removal of affinity tags from fusion proteins in recombinant protein techniques, peptide sequencing and proteolytic digestion of proteins in proteomics. The aim of this paper is to review the molecular biological aspects of proteolytic enzymes and summarize their applications in the life sciences.

  16. Research Applications of Proteolytic Enzymes in Molecular Biology

    OpenAIRE

    Mótyán, János András; Tóth, Ferenc; Tőzsér, József

    2013-01-01

    Proteolytic enzymes (also termed peptidases, proteases and proteinases) are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications ...

  17. 76 FR 67723 - CRD Hydroelectric, LLC; Notice of Application To Amend License and Accepted for Filing...

    Science.gov (United States)

    2011-11-02

    ... two turbine/generator units rather than the previously approved three units. The applicant does not propose any change to the authorized installed capacity or maximum hydraulic capacity. l. Locations of the...

  18. Photoluminescent ZnO Nanoparticles and Their Biological Applications

    Directory of Open Access Journals (Sweden)

    Zheng-Yong Zhang

    2015-05-01

    Full Text Available During the past decades, numerous achievements concerning luminescent zinc oxide nanoparticles (ZnO NPs have been reported due to their improved luminescence and good biocompatibility. The photoluminescence of ZnO NPs usually contains two parts, the exciton-related ultraviolet (UV emission and the defect-related visible emission. With respect to the visible emission, many routes have been developed to synthesize and functionalize ZnO NPs for the applications in detecting metal ions and biomolecules, biological fluorescence imaging, nonlinear multiphoton imaging, and fluorescence lifetime imaging. As the biological applications of ZnO NPs develop rapidly, the toxicity of ZnO NPs has attracted more and more attention because ZnO can produce the reactive oxygen species (ROS and release Zn2+ ions. Just as a coin has two sides, both the drug delivery and the antibacterial effects of ZnO NPs become attractive at the same time. Hence, in this review, we will focus on the progress in the synthetic methods, luminescent properties, and biological applications of ZnO NPs.

  19. Chemiluminescence. Principles and applications in biology and medicine

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A K

    1988-01-01

    Chemiluminescence, the emission of light caused by a chemical reaction, is a phenomenon used for many applications and of wide biological importance. It occurs in bacteria and insects (including glow-worms and fireflies), in many of the animals in the deep sea and even in human cells. The last 25 years have witnessed fast progress in the elucidation of the reactions and mechanisms underlying bioluminescence and light production by synthetic systems. Together with the development of highly sensitive light detectors, this has made available new biomedical methods and has given rise to new concepts concerning the biology and pathology of the cell. The book describes the occurrence, chemistry and measurement of chemiluminescence. It deals with the biological function and evolutionary significance, and looks at the many biomedical applications. The author describes the uses of chemiluminescence to measure enzymes, substrates and metabolites, to detect the changes of calcium concentration in living cells, to determine oxygen radicals or to replace the radioactive labels in immunoassays. Future applications in research and clinical laboratories are also discussed.

  20. Safety and licensing of MOX versus UO2 for BWRs and PWRs: Aspects applicable for civilian and weapons grade Pu

    International Nuclear Information System (INIS)

    Goldstein, L.; Malone, J.

    2000-01-01

    This paper reviews the safety and licensing differences between MOX and UO 2 BWR and PWR cores. MOX produced from the normal recycle route and from weapons grade material are considered. Reload quantities of recycle MOX assemblies have been licensed and continue to operate safely in European LWRs. In general, the European MOX assemblies in a reload are 2 . These studies indicated that no important technical or safety related issues have evolved from these studies. The general specifications used by fuel vendors for recycled MOX fuel and core designs are as follows: MOX assemblies should be designed to minimize or eliminate local power peaking mismatches with co-resident and adjacently loaded UO 2 assemblies. Power peaking at the interfaces arises from different neutronic behavior between UO 2 and MOX assemblies. A MOX core (MOX and UO 2 or all-MOX assemblies) should provide cycle energy equivalent to that of an all-UO 2 core. This applies, in particular, to recycle MOX applications. An important consideration when burning weapons grade material is rapid disposition which may not necessarily allow for cycle energy equivalence. The reactivity coefficients, kinetics data, power peaking, and the worth of shutdown systems with MOX fuel and cores must be such to meet the design criteria and fulfill requirements for safe reactor operation. Both recycle and weapons grade plutonium are considered, and positive and negative impacts are given. The paper contrasts MOX versus UO 2 with respect to safety evaluations. The consequences of some transients/accidents are compared for both types of MOX and UO 2 fuel. (author)

  1. 75 FR 3217 - J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-01-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11392-009] J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License and Soliciting Comments and Motions To Intervene January 12, 2010. On October 30, 2009, J&T Hydro Company (transferor) and...

  2. 75 FR 15419 - Notice of Intent To Grant Exclusive License of U.S. Patent Application No. 12/432,842 Filed April...

    Science.gov (United States)

    2010-03-29

    ... Exclusive License of U.S. Patent Application No. 12/432,842 Filed April 30, 2009 Entitled: ``A Soil Stabilization Soil Comprising Same, and a Method of Stabilizing Soil'' AGENCY: Department of the Army, U.S. Army... climates with sandy, gravelly soils where emulsions and hydraulic cements will not effectively cure. If...

  3. 77 FR 9998 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2012-02-21

    ... more conservative values that incorporate measurement uncertainty. Additionally, one of the operating..., in accordance with 10 CFR 2.302(g), with their initial paper filing requesting authorization to... purpose of the adjudicatory filings and would constitute a Fair Use application, participants are...

  4. 77 FR 10491 - Progress Energy Carolinas, Inc.; Notice of Application for Amendment of License and Soliciting...

    Science.gov (United States)

    2012-02-22

    ... ensuring the continued safe and reliable production of hydroelectric power at the project. Among other... Intervene, and Protests Take notice that the following hydroelectric application has been filed with the.... Name of Project: Yadkin-Pee Dee Hydroelectric Project. f. Location: Lake Tillery in Montgomery and...

  5. 77 FR 28372 - South Carolina Public Service Authority; Notice of Application for Amendment of License and...

    Science.gov (United States)

    2012-05-14

    ... documents may be filed electronically via the Internet. See, 18 CFR 385.2001(a)(1)(iii) and the instructions... marina, fuel and sewage pump-out services, restrooms, parking, shops, restaurant, swimming pool, rental cottages, boardwalk, wooden deck, and remote parking for boat trailers. l. Locations of the Application: A...

  6. 77 FR 38618 - Idaho Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-06-28

    ... Hydroelectric Project. f. Location: The project is located in south-western Idaho on the Snake River from river... application is available for inspection and reproduction at the Commission's Public Reference Room, located at... available for inspection and reproduction at the address in item (h) above. m. Individuals desiring to be...

  7. 76 FR 51016 - Idaho Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-08-17

    .... Name of Project: Twin Falls Hydroelectric Project. f. Location: This project is located on the Snake... application is available for inspection and reproduction at the Commission's Public Reference Room, located at... available for inspection and reproduction at the address in item (h) above. m. Individuals desiring to be...

  8. 78 FR 51753 - AUC, LLC Reno Creek, In Situ Project, New Source Material License Application

    Science.gov (United States)

    2013-08-21

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 040-09092; [NRC-2013-0164] AUC, LLC Reno Creek, In Situ..., AUC, LLC (AUC) submitted to the U.S. Nuclear Regulatory Commission (NRC) an application for a new... and operation, and decommissioning of AUC's proposed in-situ uranium recovery (ISR, also known as in...

  9. 76 FR 3927 - Ameren Missouri; Combined License Application for Callaway Plant Unit 2; Exemption

    Science.gov (United States)

    2011-01-21

    ... public health or safety, and are consistent with the common defense and security; and (2) special... only temporary relief from the applicable regulation and the licensee has made good faith efforts to... good faith efforts to comply with 10 CFR 50.71(e)(3)(iii) by submitting Revision 1 to the COL...

  10. 77 FR 76539 - Ameren Missouri; Combined License Application For Callaway Plant, Unit 2; Exemption

    Science.gov (United States)

    2012-12-28

    ... present an undue risk to public health or safety, and are consistent with the common defense and security... regulation and the licensee or applicant has made good faith efforts to comply with the regulation'' (10 CFR... good faith efforts to comply with 10 CFR 50.71(e)(3)(iii) by submitting Revision 1 to the COL...

  11. 77 FR 63301 - Juneau Hydropower, Inc.; Notice of Draft License Application and Preliminary Draft Environmental...

    Science.gov (United States)

    2012-10-16

    .... 791(a)-825(r). h. Applicant Contact: Duff Mitchell, Business Manager, Juneau Hydropower, Inc., P.O... information at the end of your comments. For assistance, please contact FERC Online Support at FERCOnline... access the document. For assistance, contact FERC Online Support. You may also register online at http...

  12. 76 FR 18801 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-04-05

    ... request: The proposed change would revise the application of Risk-Managed Technical Specifications (RMTS) to Technical Specification (TS) 3.7.7, ``Control Room Makeup and Cleanup Filtration System.'' This... change allows the Configuration Risk Management Program (CRMP) to be applied to Technical Specification...

  13. Viability Assessment of a Repository at Yucca Mountain. Volume 4: License Application Plan and Costs

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-01

    defensible LA. Volume 4 is divided into seven sections. Section 2 presents a rationale and summary for the technical work to be done to develop the preclosure and postclosure safety cases that will support the compliance evaluations required for the evaluation of site suitability and for licensing. Section 2 also describes other necessary technical work, including that needed to support design decisions and development of the necessary design information. Section 3 presents a more detailed description of the technical work required to address the issues identified in Section 2. Section 3 also describes activities that will continue after submittal of the site recommendation and the LA. Examples include the drift scale heater test in the Exploratory Studies Facility (Section 3.1.4.3) and long-term waste package corrosion testing (Section 3.2.2.9). Section 4 discusses the statutory and regulatory framework for site recommendation and submittal of an LA, and describes the activities and documentation that must be completed to achieve these milestones, including the development of an EIS. Section 5 describes the numerous activities required to support program milestones, including support for completing the testing program, continuing tests as part of the performance confirmation program, and managing information and records to support regulatory and legal review. Sections 6 and 7 provide cost and schedule information for the activities planned.

  14. Studies on the Promotion of Biological Application by Radiation

    International Nuclear Information System (INIS)

    No, Y. C.; Kuk, I. H.; Song, H. S.

    2006-03-01

    Radiation Technology (RT) has been widely used in most of all fields of industries, medical, bioresources, food and agriculture, public hygiene, and environment. Therefore, its application has been also researched in various parts. For industrialization of the developed technology, not only the application technology will be developed, but the accurate dosimetry and improvement of the services of irradiation practice should be performed as soon as possible. Evaluation of effects and reaction mechanism of biological materials by irradiation was performed in this year in the long term research planning. The researches and experiments were well performed and the good results were obtained. The results may be donated in the progress of radiation biology and the new establishment on the application of RT. Also, one of the results was the evaluation of the structural changes of biomolecules and its application in the fields of food and biotechnology industries. Advanced Radiation Technology Institute (ARTI) will be well settled down and promotion of research activity of newly established institute by the fundamental support of KAERI. And, ARTI can get the goal where the vision of the hub of RT in Asia/Pacific region by 2020

  15. Flexible licensing

    Directory of Open Access Journals (Sweden)

    Martyn Jansen

    2012-07-01

    Full Text Available The case is presented for a more flexible approach to licensing online library resources. Today's distributed education environment creates pressure for UK higher and further education institutions (HEI/FEIs to form partnerships and to develop educational products and roll them out across the globe. Online library resources are a key component of distributed education and yet existing licensing agreements struggle to keep pace with the increasing range of users and purposes for which they are required. This article describes the process of developing a flexible approach to licensing and proposes a new model licence for online library resources which has the adaptability needed in this new global educational landscape. These ideas have been presented and discussed at various workshops across Eduserv's and JISC Collections' higher education and publisher communities, and further consultation is ongoing.

  16. Marble Hill Nuclear Generating Station, Units 1 and 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    1975-01-01

    An application is presented for two PWR reactors to be constructed in Salud Township, Jefferson County, Indiana, about six miles northeast of New Washington on the Ohio River. Each unit will have a rated core power level of 3411 MW(t) with a corresponding electrical output of 1130 MW(e). Mechanical draft cooling towers will be provided. The facility, which will replicate the Byron facility will be employed for the generation of electricity for transmission, sale for resale, and distribution

  17. Black Fox Station, Units 1 and 2. Application for construction permits and operating licenses

    International Nuclear Information System (INIS)

    1975-01-01

    An application to construct and operate Black Fox Station, Units 1 and 2, is presented. The two BWR type reactors will have a rated core thermal power of 3579 MW(t) and a net electrical power of approximately 1150 MW(e). The facility will be located in Inola Township, 23 miles east of Tulsa on the east side of the Verdigris River in Rogers County, Oklahoma

  18. Edwin I. Hatch Nuclear Plant, Unit 2. License application, general information

    International Nuclear Information System (INIS)

    1975-01-01

    An application for a direct cycle BWR is presented. The reactor will be located about 11 miles north of Baxley, Ga., near the south bank of the Ultamaha River in Appling County close to Hatch-1 Reactor. The core thermal power level will be 2537 MW(t) and the electrical power level will be 795 MW(e). Mechanical cooling towers will be utilized

  19. Licensing in BE system code calculations. Applications and uncertainty evaluation by CIAU method

    International Nuclear Information System (INIS)

    Petruzzi, Alessandro; D'Auria, Francesco

    2007-01-01

    The evaluation of uncertainty constitutes the necessary supplement of Best Estimate (BE) calculations performed to understand accident scenarios in water cooled nuclear reactors. The needs come from the imperfection of computational tools on the one side and from the interest in using such tool to get more precise evaluation of safety margins. In the present paper the approaches to uncertainty are outlined and the CIAU (Code with capability of Internal Assessment of Uncertainty) method proposed by the University of Pisa is described including ideas at the basis and results from applications. Two approaches are distinguished that are characterized as 'propagation of code input uncertainty' and 'propagation of code output errors'. For both methods, the thermal-hydraulic code is at the centre of the process of uncertainty evaluation: in the former case the code itself is adopted to compute the error bands and to propagate the input errors, in the latter case the errors in code application to relevant measurements are used to derive the error bands. The CIAU method exploits the idea of the 'status approach' for identifying the thermal-hydraulic conditions of an accident in any Nuclear Power Plant (NPP). Errors in predicting such status are derived from the comparison between predicted and measured quantities and, in the stage of the application of the method, are used to compute the uncertainty. (author)

  20. Synthetic glycopeptides and glycoproteins with applications in biological research

    Directory of Open Access Journals (Sweden)

    Ulrika Westerlind

    2012-05-01

    Full Text Available Over the past few years, synthetic methods for the preparation of complex glycopeptides have been drastically improved. The need for homogenous glycopeptides and glycoproteins with defined chemical structures to study diverse biological phenomena further enhances the development of methodologies. Selected recent advances in synthesis and applications, in which glycopeptides or glycoproteins serve as tools for biological studies, are reviewed. The importance of specific antibodies directed to the glycan part, as well as the peptide backbone has been realized during the development of synthetic glycopeptide-based anti-tumor vaccines. The fine-tuning of native chemical ligation (NCL, expressed protein ligation (EPL, and chemoenzymatic glycosylation techniques have all together enabled the synthesis of functional glycoproteins. The synthesis of structurally defined, complex glycopeptides or glyco-clusters presented on natural peptide backbones, or mimics thereof, offer further possibilities to study protein-binding events.

  1. Classical and spatial stochastic processes with applications to biology

    CERN Document Server

    Schinazi, Rinaldo B

    2014-01-01

    The revised and expanded edition of this textbook presents the concepts and applications of random processes with the same illuminating simplicity as its first edition, but with the notable addition of substantial modern material on biological modeling. While still treating many important problems in fields such as engineering and mathematical physics, the book also focuses on the highly relevant topics of cancerous mutations, influenza evolution, drug resistance, and immune response. The models used elegantly apply various classical stochastic models presented earlier in the text, and exercises are included throughout to reinforce essential concepts. The second edition of Classical and Spatial Stochastic Processes is suitable as a textbook for courses in stochastic processes at the advanced-undergraduate and graduate levels, or as a self-study resource for researchers and practitioners in mathematics, engineering, physics, and mathematical biology. Reviews of the first edition: An appetizing textbook for a f...

  2. Persistent phosphors for painting, medical and biological applications

    International Nuclear Information System (INIS)

    Nazarov, M.

    2013-01-01

    Multiphase micro and nanoparticle persistent phosphors are synthesized and applied for different fields including painting, medical and biological investigations. A lot of examples show a broad range of applications of persistent luminescence from bulk materials to high tech products, especially in medicine. The development of high efficiency nanosized phosphor makes it possible to propose persistent materials as very good candidates for photodynamic therapy of cancer. An artificial block from slag, concrete, and sand covered with SrAl 2 O 4 :Eu 2+ , Dy 3+ based phosphor is prepared, and a new direction in biology for algae cultivation and artificial reef is discussed. For the first time, underwater luminescence is experimentally studied under real sea conditions. Bright blue-green long-lasting afterglow is registered at a depth of 5 m. The fishes are attracted by the light of the artificial reef. (author)

  3. Radioactive indicators in biology and their medical applications

    International Nuclear Information System (INIS)

    Morel, F.

    1950-12-01

    This talk was given at the society of promotion of the national industry on December 1, 1949. The report is a pre-print of an article published in L'Industrie Nationale no.2 (1950). It presents the state-of-the-art of the use of artificial radioisotopes in biology and medicine: 1 - definitions (isotopes, decay, radiation emission); 2 - modalities of the use of radioisotopes in biology: basic instrumentation (Geiger-Mueller counter, counting techniques, photography, auto-histo-radiography); 3 - applications in physiology (digestive absorption, excretion, vascular exchanges, tracer techniques) and biochemistry (metabolism, thyroxine synthesis and fixation indicators, tracer techniques for drugs); 4 - radiotherapy, internal and external irradiation. (J.S.)

  4. Application of enriched stable isotopes as tracers in biological systems

    DEFF Research Database (Denmark)

    Stürup, Stefan; Hansen, Helle Rüsz; Gammelgaard, Bente

    2008-01-01

    The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry...... (ICP-MS) instrumentation, such as reaction/collision cell ICP-MS and multicollector ICP-MS with improved isotope ratio measurement and interference removal capabilities. Adaptation and refinement of radioisotope tracer experiment methodologies for enriched stable isotope experiments......, and the development of new methodologies coupled with more advanced compartmental and mathematical models for the distribution of elements in living organisms has enabled a broader use of enriched stable isotope experiments in the biological sciences. This review discusses the current and future uses of enriched...

  5. Integrated ground-water monitoring strategy for NRC-licensed facilities and sites: Case study applications

    Science.gov (United States)

    Price, V.; Temples, T.; Hodges, R.; Dai, Z.; Watkins, D.; Imrich, J.

    2007-01-01

    This document discusses results of applying the Integrated Ground-Water Monitoring Strategy (the Strategy) to actual waste sites using existing field characterization and monitoring data. The Strategy is a systematic approach to dealing with complex sites. Application of such a systematic approach will reduce uncertainty associated with site analysis, and therefore uncertainty associated with management decisions about a site. The Strategy can be used to guide the development of a ground-water monitoring program or to review an existing one. The sites selected for study fall within a wide range of geologic and climatic settings, waste compositions, and site design characteristics and represent realistic cases that might be encountered by the NRC. No one case study illustrates a comprehensive application of the Strategy using all available site data. Rather, within each case study we focus on certain aspects of the Strategy, to illustrate concepts that can be applied generically to all sites. The test sites selected include:Charleston, South Carolina, Naval Weapons Station,Brookhaven National Laboratory on Long Island, New York,The USGS Amargosa Desert Research Site in Nevada,Rocky Flats in Colorado,C-Area at the Savannah River Site in South Carolina, andThe Hanford 300 Area.A Data Analysis section provides examples of detailed data analysis of monitoring data.

  6. Application of the selected physical methods in biological research

    Directory of Open Access Journals (Sweden)

    Jaromír Tlačbaba

    2013-01-01

    Full Text Available This paper deals with the application of acoustic emission (AE, which is a part of the non-destructive methods, currently having an extensive application. This method is used for measuring the internal defects of materials. AE has a high potential in further research and development to extend the application of this method even in the field of process engineering. For that matter, it is the most elaborate acoustic emission monitoring in laboratory conditions with regard to external stimuli. The aim of the project is to apply the acoustic emission recording the activity of bees in different seasons. The mission is to apply a new perspective on the behavior of colonies by means of acoustic emission, which collects a sound propagation in the material. Vibration is one of the integral part of communication in the community. Sensing colonies with the support of this method is used for understanding of colonies biological behavior to stimuli clutches, colony development etc. Simulating conditions supported by acoustic emission monitoring system the illustrate colonies activity. Collected information will be used to represent a comprehensive view of the life cycle and behavior of honey bees (Apis mellifera. Use of information about the activities of bees gives a comprehensive perspective on using of acoustic emission in the field of biological research.

  7. Click Chemistry Mediated Functionalization of Vertical Nanowires for Biological Applications.

    Science.gov (United States)

    Vutti, Surendra; Schoffelen, Sanne; Bolinsson, Jessica; Buch-Månson, Nina; Bovet, Nicolas; Nygård, Jesper; Martinez, Karen L; Meldal, Morten

    2016-01-11

    Semiconductor nanowires (NWs) are gaining significant importance in various biological applications, such as biosensing and drug delivery. Efficient and controlled immobilization of biomolecules on the NW surface is crucial for many of these applications. Here, we present for the first time the use of the Cu(I) -catalyzed alkyne-azide cycloaddition and its strain-promoted variant for the covalent functionalization of vertical NWs with peptides and proteins. The potential of the approach was demonstrated in two complementary applications of measuring enzyme activity and protein binding, which is of general interest for biological studies. The attachment of a peptide substrate provided NW arrays for the detection of protease activity. In addition, green fluorescent protein was immobilized in a site-specific manner and recognized by antibody binding to demonstrate the proof-of-concept for the use of covalently modified NWs for diagnostic purposes using minute amounts of material. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    2000-01-01

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  9. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  10. Applications of positron annihilation spectroscopy to polymeric and biological systems

    International Nuclear Information System (INIS)

    Jean, Y.C.; Chen, Hongmin; Liu, Guang; Chakka, Lakshmi; Gadzia, Joseph E.

    2007-01-01

    Positron annihilation spectroscopy (PAS) is a novel radio-analytical technique which uses the positron (anti-electron) and is capable of probing the atomic and molecular scale (0.2-2 nm) free-volume and hole properties in polymeric and biological materials. Recently, we developed positron annihilation lifetime and Doppler broadening of energy spectroscopies coupled with a variable mono-energetic positron beam to measure the free-volume depth profile from the surface, interfaces, and to the bulk. This paper presents applications of PAS to determine multi-layer structures, glass transition temperatures in nano-scale polymeric films and to detect cancer in the human skin. (author)

  11. Pulsed electrical discharges for medicine and biology techniques, processes, applications

    CERN Document Server

    Kolikov, Victor

    2015-01-01

    This book presents the application of pulsed electrical discharges in water and water dispersions of metal nanoparticles in medicine (surgery, dentistry, and oncology), biology, and ecology. The intensive electrical and shock waves represent a novel technique to destroy viruses and this way to  prepare anti-virus vaccines. The method of pulsed electrical discharges in water allows to decontaminate water from almost all known bacteria and spores of fungi being present in human beings. The nanoparticles used are not genotoxic and mutagenic. This book is useful for researchers and graduate students.

  12. 75 FR 4571 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-01-28

    .... Applications: Therapies for tumors associated with NF1 (including brain and peripheral nervous system tumors...-US-01). Licensing Status: Available for licensing. Licensing Contact: Patrick P. McCue, Ph.D.; 301...

  13. Multiscale Model Simulations of Temperature and Relative Humidity for the License Application of the Proposed Yucca Mountain Repository

    Science.gov (United States)

    Buscheck, T.; Glascoe, L.; Sun, Y.; Gansemer, J.; Lee, K.

    2003-12-01

    ; these variables are determined every 20 m for each emplacement drift in the repository. The MSTHM accounts for 3-D drift-scale and mountain-scale heat flow and captures the influence of the key engineering-design variables and natural-system factors affecting TH conditions in the emplacement drifts and adjoining host rock. Presented is a synopsis of recent MSTHM calculations conducted to support the Total System Performance Assessment for the License Application (TSPA-LA). This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  14. Clinch River Breeder Reactor Plant. License application, statement of general information

    International Nuclear Information System (INIS)

    1975-01-01

    Application is made for a reactor facility consisting of a liquid metal cooled reactor and steam generator system, a steam turbine driven electric generating system, electrical switchyard, and related auxiliaries and supporting structures. The primary system is located in an inert atmosphere in shielded vaults within a containment structure. Sodium coolant is used to remove heat from the core and radial blanket. Heat from the primary sodium is transferred in heat exchangers to non radioactive sodium which is used to convert feed-water into steam which is superheated to drive a tandem-compound generator. A single shaft multi-stage turbine generator produces 380 MW(e) with steam conditions of 1450 psig at 900 0 F. Fuel is sintered ceramic pellets of mixed uranium-plutonium oxides encapsulated in stainless steel. There are 198 fuel assemblies with each assembly consisting of 217 fuel rods placed in a hexagonal channel. Plutonium enrichment ranges from 1817 to 32.0 percent by weight. Axial blanket sections contain depleted UO 2 with 99.8 percent 238 U and 0.2 percent 235 U by weight. The proposed location of the plant is within the corporate limits of the city of Oak Ridge in Roane County, Tennessee. (U.S.)

  15. Clinical application analysis of andrographolide total ester sulfonate injection, a traditional Chinese medicine licensed in China.

    Science.gov (United States)

    Zhao, Ying; Huang, Pu; Chen, Zhe; Zheng, Si-Wei; Yu, Jin-Yang; Shi, Chen

    2017-04-01

    Andrographolide total ester sulfonate (ATES) injection is one of the products of traditional Chinese medicine (TCM) currently used against viral infection in China. ATES injection was approved for manufacturing and marketing in January 2002. It is indicated for acute respiratory infections, tonsillitis, chronic obstructive pulmonary disease, influenza, foot and mouth disease, bronchiolitis, herpangina, mumps, infectious mononucleosis and psychosis. However, its usage also carries risk. We investigated the use of ATES at the Wuhan Union Hospital from January 2014 to December 2014 and evaluated its real-world clinical application using the hospital centralized monitoring method. A total of 848 cases were enrolled in this study. In these cases, it was mainly used for postoperative anti-inflammation and treating upper respiratory infection, pneumonia and bronchitis. Among them, 39.86% were contraindicated. Irregular medication of adults and children accounted for 1.91% and 23.38%, respectively. Improper choice of solvent accounted for 3.18%. The choice of intravenous drip versus aerosol inhalation was reasonable. A case of adverse events (AEs) was observed in the monitoring period, and the incidence of adverse drug reaction (ADR) of ATES injection was 0.12%. ATES injection in our hospital is relatively safe with a low incidence of adverse reactions. The study assesses the clinical usage and adverse reactions of ATES injection, and provides suggestions for rational use in clinical practice.

  16. An atomic force microscope nanoscalpel for nanolithography and biological applications

    Energy Technology Data Exchange (ETDEWEB)

    Beard, J D; Burbridge, D J; Moskalenko, A V; Dudko, O; Gordeev, S N [Department of Physics, University of Bath, Bath BA2 7AY (United Kingdom); Yarova, P L; Smirnov, S V, E-mail: jdb28@bath.ac.u [Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY (United Kingdom)

    2009-11-04

    We present the fabrication of specialized nanotools, termed nanoscalpels, and their application for nanolithography and nanomechanical manipulation of biological objects. Fabricated nanoscalpels have the shape of a thin blade with the controlled thickness of 20-30 nm and width of 100-200 nm. They were fabricated using electron beam induced deposition at the apex of atomic force microscope probes and are hard enough for a single cut to penetrate a {approx}45 nm thick gold layer; and thus can be used for making narrow electrode gaps required for fabrication of nanoelectronic devices. As an atomic force microscope-based technique the nanoscalpel provides simultaneous control of the applied cutting force and the depth of the cut. Using mammalian cells as an example, we demonstrated their ability to make narrow incisions and measurements of local elastic and inelastic characteristics of a cell, making nanoscalpels also useful as a nanosurgical tool in cell biology. Therefore, we believe that the nanoscalpel could serve as an important tool for nanofabrication and nanosurgery on biological objects.

  17. Ortholog prediction of the Aspergillus genus applicable for synthetic biology

    DEFF Research Database (Denmark)

    Rasmussen, Jane Lind Nybo; Vesth, Tammi Camilla; Theobald, Sebastian

    of genotype-to-phenotype. To achieve this, we have developed orthologous protein prediction software that utilizes genus-wide genetic diversity. The approach is optimized for large data sets, based on BLASTp considering protein identity and alignment coverage, and clustering using single linkage of bi......The Aspergillus genus contains leading industrial microorganisms, excelling in producing bioactive compounds and enzymes. Using synthetic biology and bioinformatics, we aim to re-engineer these organisms for applications within human health, pharmaceuticals, environmental engineering, and food......-directional hits. The result is orthologous protein families describing the genomic and functional features of individual species, clades and the core/pan genome of Aspergillus; and applicable to genotype-to-phenotype analyses in other microbial genera....

  18. Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

    Science.gov (United States)

    Castro-Manrreza, Marta E.; Montesinos, Juan J.

    2015-01-01

    Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into mesenchymal lineages and that can be isolated from various tissues and easily cultivated in vitro. Currently, MSCs are of considerable interest because of the biological characteristics that confer high potential applicability in the clinical treatment of many diseases. Specifically, because of their high immunoregulatory capacity, MSCs are used as tools in cellular therapies for clinical protocols involving immune system alterations. In this review, we discuss the current knowledge about the capacity of MSCs for the immunoregulation of immunocompetent cells and emphasize the effects of MSCs on T cells, principal effectors of the immune response, and the immunosuppressive effects mediated by the secretion of soluble factors and membrane molecules. We also describe the mechanisms of MSC immunoregulatory modulation and the participation of MSCs as immune response regulators in several autoimmune diseases, and we emphasize the clinical application in graft versus host disease (GVHD). PMID:25961059

  19. Biological applications of phase-contrast electron microscopy.

    Science.gov (United States)

    Nagayama, Kuniaki

    2014-01-01

    Here, I review the principles and applications of phase-contrast electron microscopy using phase plates. First, I develop the principle of phase contrast based on a minimal model of microscopy, introducing a double Fourier-transform process to mathematically formulate the image formation. Next, I explain four phase-contrast (PC) schemes, defocus PC, Zernike PC, Hilbert differential contrast, and schlieren optics, as image-filtering processes in the context of the minimal model, with particular emphases on the Zernike PC and corresponding Zernike phase plates. Finally, I review applications of Zernike PC cryo-electron microscopy to biological systems such as protein molecules, virus particles, and cells, including single-particle analysis to delineate three-dimensional (3D) structures of protein and virus particles and cryo-electron tomography to reconstruct 3D images of complex protein systems and cells.

  20. Micro-segmented flow applications in chemistry and biology

    CERN Document Server

    Cahill, Brian

    2014-01-01

    The book is dedicated to the method and application potential of micro segmented flow. The recent state of development of this powerful technique is presented in 12 chapters by leading researchers from different countries. In the first section, the principles of generation and manipulation of micro-fluidic segments are explained. In the second section, the micro continuous-flow synthesis of different types of nanomaterials is shown as a typical example for the use of advantages of the technique in chemistry. In the third part, the particular importance of the technique in biotechnical applications is presented demonstrating the progress for miniaturized cell-free processes, for molecular biology and DNA-based diagnostis and sequencing as well as for the development of antibiotics and the evaluation of toxic effects in medicine and environment.

  1. Applications of Chitin and Its Derivatives in Biological Medicine

    Directory of Open Access Journals (Sweden)

    Moon-Moo Kim

    2010-12-01

    Full Text Available Chitin and its derivatives—as a potential resource as well as multiple functional substrates—have generated attractive interest in various fields such as biomedical, pharmaceutical, food and environmental industries, since the first isolation of chitin in 1811. Moreover, chitosan and its chitooligosaccharides (COS are degraded products of chitin through enzymatic and acidic hydrolysis processes; and COS, in particular, is well suited for potential biological application, due to the biocompatibility and nontoxic nature of chitosan. In this review, we investigate the current bioactivities of chitin derivatives, which are all correlated with their biomedical properties. Several new and cutting edge insights here may provide a molecular basis for the mechanism of chitin, and hence may aid its use for medical and pharmaceutical applications.

  2. Review on thin-film transistor technology, its applications, and possible new applications to biological cells

    Science.gov (United States)

    Tixier-Mita, Agnès; Ihida, Satoshi; Ségard, Bertrand-David; Cathcart, Grant A.; Takahashi, Takuya; Fujita, Hiroyuki; Toshiyoshi, Hiroshi

    2016-04-01

    This paper presents a review on state-of-the-art of thin-film transistor (TFT) technology and its wide range of applications, not only in liquid crystal displays (TFT-LCDs), but also in sensing devices. The history of the evolution of the technology is first given. Then the standard applications of TFT-LCDs, and X-ray detectors, followed by state-of-the-art applications in the field of chemical and biochemical sensing are presented. TFT technology allows the fabrication of dense arrays of independent and transparent microelectrodes on large glass substrates. The potential of these devices as electrical substrates for biological cell applications is then described. The possibility of using TFT array substrates as new tools for electrical experiments on biological cells has been investigated for the first time by our group. Dielectrophoresis experiments and impedance measurements on yeast cells are presented here. Their promising results open the door towards new applications of TFT technology.

  3. Core/Shell Structured Magnetic Nanoparticles for Biological Applications

    International Nuclear Information System (INIS)

    Park, Jeong Chan; Jung, Myung Hwan

    2013-01-01

    Magnetic nanoparticles have been widely used for biomedical applications, such as magnetic resonance imaging (MRI), hyperthermia, drug delivery and cell signaling. The surface modification of the nanomaterials is required for biomedical use to give physiogical stability, surface reactivity and targeting properties. Among many approaches for the surface modification with materials, such as polymers, organic ligands and metals, one of the most attractive ways is using metals. The fabrication of metal-based, monolayer-coated magnetic nanoparticles has been intensively studied. However, the synthesis of metal-capped magnetic nanoparticles with monodispersities and controllable sizes is still challenged. Recently, gold-capped magnetic nanoparticles have been reported to increase stability and to provide biocompatibility. Magnetic nanoparticle with gold coating is an attractive system, which can be stabilized in biological conditions and readily functionalized in biological conditions and readily functionalized through well-established surface modification (Au-S) chemistry. The Au coating offers plasmonic properties to magnetic nanoparticles. This makes the magnetic/Au core/shell combinations interesting for magnetic and optical applications. Herein, the synthesis and characterization of gold capped-magnetic core structured nanomaterials with different gold sources, such as gold acetate and chloroauric acid have been reported. The core/shell nanoparticles were transferred from organic to aqueous solutions for biomedical applications. Magnetic core/shell structured nanoparticles have been prepared and transferred from organic phase to aqueous solutions. The resulting Au-coated magnetic core nanoparticles might be an attractive system for biomedical applications, which are needed both magnetic resonance imaging and optical imaging

  4. Licensing safety critical software

    International Nuclear Information System (INIS)

    Archinoff, G.H.; Brown, R.A.

    1990-01-01

    Licensing difficulties with the shutdown system software at the Darlington Nuclear Generating Station contributed to delays in starting up the station. Even though the station has now been given approval by the Atomic Energy Control Board (AECB) to operate, the software issue has not disappeared - Ontario Hydro has been instructed by the AECB to redesign the software. This article attempts to explain why software based shutdown systems were chosen for Darlington, why there was so much difficulty licensing them, and what the implications are for other safety related software based applications

  5. Application of proteomics to ecology and population biology.

    Science.gov (United States)

    Karr, T L

    2008-02-01

    Proteomics is a relatively new scientific discipline that merges protein biochemistry, genome biology and bioinformatics to determine the spatial and temporal expression of proteins in cells, tissues and whole organisms. There has been very little application of proteomics to the fields of behavioral genetics, evolution, ecology and population dynamics, and has only recently been effectively applied to the closely allied fields of molecular evolution and genetics. However, there exists considerable potential for proteomics to impact in areas related to functional ecology; this review will introduce the general concepts and methodologies that define the field of proteomics and compare and contrast the advantages and disadvantages with other methods. Examples of how proteomics can aid, complement and indeed extend the study of functional ecology will be discussed including the main tool of ecological studies, population genetics with an emphasis on metapopulation structure analysis. Because proteomic analyses provide a direct measure of gene expression, it obviates some of the limitations associated with other genomic approaches, such as microarray and EST analyses. Likewise, in conjunction with associated bioinformatics and molecular evolutionary tools, proteomics can provide the foundation of a systems-level integration approach that can enhance ecological studies. It can be envisioned that proteomics will provide important new information on issues specific to metapopulation biology and adaptive processes in nature. A specific example of the application of proteomics to sperm ageing is provided to illustrate the potential utility of the approach.

  6. Quasielastic neutron scattering in biology: Theory and applications.

    Science.gov (United States)

    Vural, Derya; Hu, Xiaohu; Lindner, Benjamin; Jain, Nitin; Miao, Yinglong; Cheng, Xiaolin; Liu, Zhuo; Hong, Liang; Smith, Jeremy C

    2017-01-01

    Neutrons scatter quasielastically from stochastic, diffusive processes, such as overdamped vibrations, localized diffusion and transitions between energy minima. In biological systems, such as proteins and membranes, these relaxation processes are of considerable physical interest. We review here recent methodological advances and applications of quasielastic neutron scattering (QENS) in biology, concentrating on the role of molecular dynamics simulation in generating data with which neutron profiles can be unambiguously interpreted. We examine the use of massively-parallel computers in calculating scattering functions, and the application of Markov state modeling. The decomposition of MD-derived neutron dynamic susceptibilities is described, and the use of this in combination with NMR spectroscopy. We discuss dynamics at very long times, including approximations to the infinite time mean-square displacement and nonequilibrium aspects of single-protein dynamics. Finally, we examine how neutron scattering and MD can be combined to provide information on lipid nanodomains. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Biological effects and medical applications of infrared radiation.

    Science.gov (United States)

    Tsai, Shang-Ru; Hamblin, Michael R

    2017-05-01

    Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760nm and 100,000nm. Low-level light therapy (LLLT) or photobiomodulation (PBM) therapy generally employs light at red and near-infrared wavelengths (600-100nm) to modulate biological activity. Many factors, conditions, and parameters influence the therapeutic effects of IR, including fluence, irradiance, treatment timing and repetition, pulsing, and wavelength. Increasing evidence suggests that IR can carry out photostimulation and photobiomodulation effects particularly benefiting neural stimulation, wound healing, and cancer treatment. Nerve cells respond particularly well to IR, which has been proposed for a range of neurostimulation and neuromodulation applications, and recent progress in neural stimulation and regeneration are discussed in this review. The applications of IR therapy have moved on rapidly in recent years. For example, IR therapy has been developed that does not actually require an external power source, such as IR-emitting materials, and garments that can be powered by body heat alone. Another area of interest is the possible involvement of solar IR radiation in photoaging or photorejuvenation as opposites sides of the coin, and whether sunscreens should protect against solar IR? A better understanding of new developments and biological implications of IR could help us to improve therapeutic effectiveness or develop new methods of PBM using IR wavelengths. Copyright © 2016. Published by Elsevier B.V.

  8. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  9. Environmental Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Environmental report

    International Nuclear Information System (INIS)

    1987-04-01

    The Environmental Standard Review Plan (ESRP) (NUREG-1300) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform environmental reviews of environmental reports prepared by applicants in support of license applications to construct and operate new low-level radioactive waste disposal facilities. The individual ESRPs that constitute this document identify the information considered necessary to conduct the review, the purpose and scope of the review, the analysis procedure and evaluation, the formal input to the environmental statement, and the references considered appropriate for each review. The ESRP is intended to ensure quality and uniformity of approach in individual reviews as well as compliance with the National Environmental Policy Act of 1969. In addition, the ESRP will make information about the environmental component of the licensing process more readily available and thereby will serve to improve the understanding of this process among the public, States and regional compacts, and the regulated community

  10. Biological applications of the Moessbauer effect; Applications de l'effet Mossbauer a la biologie

    Energy Technology Data Exchange (ETDEWEB)

    Boulay, P [CEA Bruyeres-le-Chatel, 91 (France)

    1968-12-01

    The applications of Moessbauer spectrometry in the fields of physics and chemistry have been increasing steadily since its discovery in 1958. Attempts have been made to find applications in biology. Two possibilities of investigation exist in this field: the study of mechanical or vibrational movements in certain animal organs, and the determination of the organic molecular structure in a biological context. An example is given of each of these possibilities. (author) [French] Les applications de la spectrometrie Mossbauer dans le domaine de la physique et de la chimie n'ont cesse de progresser depuis sa decouverte en 1958. Des essais d'application a la biologie ont ete entrepris. Dans ce domaine il existe deux possibilites d'investigation: l'etude des mouvements mecaniques ou vibratoires de certaines organes d'animaux, et la determination de la structure moleculaire organique a destinee biologique. Un exemple est donne de chacune de ces possibilites. (auteur)

  11. 3D Printing Polymers with Supramolecular Functionality for Biological Applications.

    Science.gov (United States)

    Pekkanen, Allison M; Mondschein, Ryan J; Williams, Christopher B; Long, Timothy E

    2017-09-11

    Supramolecular chemistry continues to experience widespread growth, as fine-tuned chemical structures lead to well-defined bulk materials. Previous literature described the roles of hydrogen bonding, ionic aggregation, guest/host interactions, and π-π stacking to tune mechanical, viscoelastic, and processing performance. The versatility of reversible interactions enables the more facile manufacturing of molded parts with tailored hierarchical structures such as tissue engineered scaffolds for biological applications. Recently, supramolecular polymers and additive manufacturing processes merged to provide parts with control of the molecular, macromolecular, and feature length scales. Additive manufacturing, or 3D printing, generates customizable constructs desirable for many applications, and the introduction of supramolecular interactions will potentially increase production speed, offer a tunable surface structure for controlling cell/scaffold interactions, and impart desired mechanical properties through reinforcing interlayer adhesion and introducing gradients or self-assembled structures. This review details the synthesis and characterization of supramolecular polymers suitable for additive manufacture and biomedical applications as well as the use of supramolecular polymers in additive manufacturing for drug delivery and complex tissue scaffold formation. The effect of supramolecular assembly and its dynamic behavior offers potential for controlling the anisotropy of the printed objects with exquisite geometrical control. The potential for supramolecular polymers to generate well-defined parts, hierarchical structures, and scaffolds with gradient properties/tuned surfaces provides an avenue for developing next-generation biomedical devices and tissue scaffolds.

  12. Applications of Deep Learning and Reinforcement Learning to Biological Data.

    Science.gov (United States)

    Mahmud, Mufti; Kaiser, Mohammed Shamim; Hussain, Amir; Vassanelli, Stefano

    2018-06-01

    Rapid advances in hardware-based technologies during the past decades have opened up new possibilities for life scientists to gather multimodal data in various application domains, such as omics, bioimaging, medical imaging, and (brain/body)-machine interfaces. These have generated novel opportunities for development of dedicated data-intensive machine learning techniques. In particular, recent research in deep learning (DL), reinforcement learning (RL), and their combination (deep RL) promise to revolutionize the future of artificial intelligence. The growth in computational power accompanied by faster and increased data storage, and declining computing costs have already allowed scientists in various fields to apply these techniques on data sets that were previously intractable owing to their size and complexity. This paper provides a comprehensive survey on the application of DL, RL, and deep RL techniques in mining biological data. In addition, we compare the performances of DL techniques when applied to different data sets across various application domains. Finally, we outline open issues in this challenging research area and discuss future development perspectives.

  13. The safety case in support of the license application of the surface repository of low-level waste in Dessel, Belgium

    International Nuclear Information System (INIS)

    Wacquier, William; Cool, Wim

    2014-01-01

    The modern concept of the safety case, developed by the OECD/NEA for geological repositories of high- and medium-level waste has been successfully applied by ONDRAF/ NIRAS for a surface repository for Category A waste (i.e. low-level waste) in Belgium in the current project phase 2006-2012. This resulted in the submission on 31 January 2013 by ONDRAF/NIRAS of an application for a 'construction and operation license' to the safety authorities. The benefits of using the notion of the safety case have been that: i) safety has been incorporated in an integrated manner within all assessment basis, design and safety assessment activities; ii) the process of development of the license application has gained in clarity and traceability; iii) the documentation of the license application contains multiple lines of argumentation for safety rather than argumentation based only on quantitative radiological impact calculations. To offer a comprehensive view on the safety argumentation and its development, it has been found useful to develop the argumentation not only along a safety statements structure but also along the safety report structure. (authors)

  14. License plate recognition (phase B).

    Science.gov (United States)

    2010-06-01

    License Plate Recognition (LPR) technology has been used for off-line automobile enforcement purposes. The technology has seen mixed success with correct reading rate as high as 60 to 80% depending on the specific application and environment. This li...

  15. Atomic Force Microscopy Application in Biological Research: A Review Study

    Directory of Open Access Journals (Sweden)

    Surena Vahabi

    2013-06-01

    Full Text Available Atomic force microscopy (AFM is a three-dimensional topographic technique with a high atomic resolution to measure surface roughness. AFM is a kind of scanning probe microscope, and its near-field technique is based on the interaction between a sharp tip and the atoms of the sample surface. There are several methods and many ways to modify the tip of the AFM to investigate surface properties, including measuring friction, adhesion forces and viscoelastic properties as well as determining the Young modulus and imaging magnetic or electrostatic properties. The AFM technique can analyze any kind of samples such as polymers, adsorbed molecules, films or fibers, and powders in the air whether in a controlled atmosphere or in a liquid medium. In the past decade, the AFM has emerged as a powerful tool to obtain the nanostructural details and biomechanical properties of biological samples, including biomolecules and cells. The AFM applications, techniques, and -in particular- its ability to measure forces, are not still familiar to most clinicians. This paper reviews the literature on the main principles of the AFM modality and highlights the advantages of this technique in biology, medicine, and- especially- dentistry. This literature review was performed through E-resources, including Science Direct, PubMed, Blackwell Synergy, Embase, Elsevier, and Scholar Google for the references published between 1985 and 2010.

  16. Models to Study NK Cell Biology and Possible Clinical Application.

    Science.gov (United States)

    Zamora, Anthony E; Grossenbacher, Steven K; Aguilar, Ethan G; Murphy, William J

    2015-08-03

    Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. NK cells rapidly recognize and respond to abnormal cells in the absence of prior sensitization due to their wide array of germline-encoded inhibitory and activating receptors, which differs from the receptor diversity found in B and T lymphocytes that is due to the use of recombination-activation gene (RAG) enzymes. Although NK cells have traditionally been described as natural killers that provide a first line of defense prior to the induction of adaptive immunity, a more complex view of NK cells is beginning to emerge, indicating they may also function in various immunoregulatory roles and have the capacity to shape adaptive immune responses. With the growing appreciation for the diverse functions of NK cells, and recent technological advancements that allow for a more in-depth understanding of NK cell biology, we can now begin to explore new ways to manipulate NK cells to increase their clinical utility. In this overview unit, we introduce the reader to various aspects of NK cell biology by reviewing topics ranging from NK cell diversity and function, mouse models, and the roles of NK cells in health and disease, to potential clinical applications. © 2015 by John Wiley & Sons, Inc. Copyright © 2015 John Wiley & Sons, Inc.

  17. Application of Biologically-Based Lumping To Investigate the ...

    Science.gov (United States)

    People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. However, investigators have often considered complex mixtures as one lumped entity. Valuable information can be obtained from these experiments, though this simplification provides little insight into the impact of a mixture's chemical composition on toxicologically-relevant metabolic interactions that may occur among its constituents. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically-based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate performance of our PBPK model. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course kinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for the 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 non-target chemicals. Application of this biologic

  18. Various on-chip sensors with microfluidics for biological applications.

    Science.gov (United States)

    Lee, Hun; Xu, Linfeng; Koh, Domin; Nyayapathi, Nikhila; Oh, Kwang W

    2014-09-12

    In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV) and greater depth of field (DOF). As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC) testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

  19. Various On-Chip Sensors with Microfluidics for Biological Applications

    Directory of Open Access Journals (Sweden)

    Hun Lee

    2014-09-01

    Full Text Available In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR and surface-enhanced Raman scattering (SERS to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV and greater depth of field (DOF. As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

  20. Surface treatments for biological, chemical and physical applications

    CERN Document Server

    Karaman, Mustafa

    2017-01-01

    A step-by-step guide to the topic with a mix of theory and practice in the fields of biology, chemistry and physics. Straightforward and well-structured, the first chapter introduces fundamental aspects of surface treatments, after which examples from nature are given. Subsequent chapters discuss various methods to surface modification, including chemical and physical approaches, followed by the characterization of the functionalized surfaces. Applications discussed include the lotus effect, diffusion barriers, enzyme immobilization and catalysis. Finally, the book concludes with a look at future technology advances. Throughout the text, tutorials and case studies are used for training purposes to grant a deeper understanding of the topic, resulting in an essential reference for students as well as for experienced engineers in R&D.

  1. RAFT Nano-constructs: surfing to biological applications.

    Science.gov (United States)

    Boturyn, Didier; Defrancq, Eric; Dolphin, Gunnar T; Garcia, Julian; Labbe, Pierre; Renaudet, Olivier; Dumy, Pascal

    2008-02-01

    Biologically programmed molecular recognition provides the basis of all natural systems and supplies evolution-optimized functional materials from self-assembly of a limited number of molecular building blocks. Biomolecules such as peptides, nucleic acids and carbohydrates represent a diverse supply of structural building blocks for the chemist to design and fabricate new functional nanostructured architectures. In this context, we review here the chemistry we have developed to conjugate peptides with nucleic acids, carbohydrates, and organic molecules, as well as combinations thereof using a template-assembled approach. With this methodology, we have prepared new integrated functional systems exhibiting designed properties in the field of nanovectors, biosensors as well as controlled peptide self-assembly. Thus this molecular engineering approach allows for the rational design of systems with integrated tailor-made properties and paves the way to more elaborate applications by bottom-up design in the domain of nanobiosciences.

  2. Single molecule force spectroscopy: methods and applications in biology

    International Nuclear Information System (INIS)

    Shen Yi; Hu Jun

    2012-01-01

    Single molecule measurements have transformed our view of biomolecules. Owing to the ability of monitoring the activity of individual molecules, we now see them as uniquely structured, fluctuating molecules that stochastically transition between frequently many substrates, as two molecules do not follow precisely the same trajectory. Indeed, it is this discovery of critical yet short-lived substrates that were often missed in ensemble measurements that has perhaps contributed most to the better understanding of biomolecular functioning resulting from single molecule experiments. In this paper, we give a review on the three major techniques of single molecule force spectroscopy, and their applications especially in biology. The single molecular study of biotin-streptavidin interactions is introduced as a successful example. The problems and prospects of the single molecule force spectroscopy are discussed, too. (authors)

  3. Stochasticity in processes fundamentals and applications to chemistry and biology

    CERN Document Server

    Schuster, Peter

    2016-01-01

    This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed t...

  4. Normal mode analysis and applications in biological physics.

    Science.gov (United States)

    Dykeman, Eric C; Sankey, Otto F

    2010-10-27

    Normal mode analysis has become a popular and often used theoretical tool in the study of functional motions in enzymes, viruses, and large protein assemblies. The use of normal modes in the study of these motions is often extremely fruitful since many of the functional motions of large proteins can be described using just a few normal modes which are intimately related to the overall structure of the protein. In this review, we present a broad overview of several popular methods used in the study of normal modes in biological physics including continuum elastic theory, the elastic network model, and a new all-atom method, recently developed, which is capable of computing a subset of the low frequency vibrational modes exactly. After a review of the various methods, we present several examples of applications of normal modes in the study of functional motions, with an emphasis on viral capsids.

  5. DNA confinement in nanochannels: physics and biological applications

    DEFF Research Database (Denmark)

    Reisner, Walter; Pedersen, Jonas Nyvold; Austin, Robert H

    2012-01-01

    in nanochannels, creating a linear unscrolling of the genome along the channel for analysis. We will first review the fundamental physics of DNA nanochannel confinement—including the effect of varying ionic strength—and then discuss recent applications of these systems to genomic mapping. Apart from the intense...... direct assessment of the genome in its native state). In this review, we will discuss how the information contained in genomic-length single DNA molecules can be accessed via physical confinement in nanochannels. Due to self-avoidance interactions, DNA molecules will stretch out when confined...... biological interest in extracting linear sequence information from elongated DNA molecules, from a physics view these systems are fascinating as they enable probing of single-molecule conformation in environments with dimensions that intersect key physical length-scales in the 1 nm to 100μm range. (Some...

  6. Nonlinear excitation fluorescence microscopy: source considerations for biological applications

    Science.gov (United States)

    Wokosin, David L.

    2008-02-01

    Ultra-short-pulse solid-state laser sources have improved contrast within fluorescence imaging and also opened new windows of investigation in biological imaging applications. Additionally, the pulsed illumination enables harmonic scattering microscopy which yields intrinsic structure, symmetry and contrast from viable embryos, cells and tissues. Numerous human diseases are being investigated by the combination of (more) intact dynamic tissue imaging of cellular function with gene-targeted specificity and electrophysiology context. The major limitation to more widespread use of multi-photon microscopy has been the complete system cost and added complexity above and beyond commercial camera and confocal systems. The current status of all-solid-state ultrafast lasers as excitation sources will be reviewed since these lasers offer tremendous potential for affordable, reliable, "turnkey" multiphoton imaging systems. This effort highlights the single box laser systems currently commercially available, with defined suggestions for the ranges for individual laser parameters as derived from a biological and fluorophore limited perspective. The standard two-photon dose is defined by 800nm, 10mW, 200fs, and 80Mhz - at the sample plane for tissue culture cells, i.e. after the full scanning microscope system. Selected application-derived excitation wavelengths are well represented by 700nm, 780nm, ~830nm, ~960nm, 1050nm, and 1250nm. Many of the one-box lasers have fixed or very limited excitation wavelengths available, so the lasers will be lumped near 780nm, 800nm, 900nm, 1050nm, and 1250nm. The following laser parameter ranges are discussed: average power from 200mW to 2W, pulse duration from 70fs to 700fs, pulse repetition rate from 20MHz to 200MHz, with the laser output linearly polarized with an extinction ratio at least 100:1.

  7. Applications of synchrotron radiation in biology and medicine

    International Nuclear Information System (INIS)

    Khole, V.

    1988-01-01

    This paper discusses the important role of synchrotron radiation in dealing with problems in various branches of biology and medicine, viz. molecular biology, molecular biophysics, biochemistry, cell biology, X-ray microscopy, molecular surgery, medical diagnostics (angiography, X-ray radiography, forensic medicine, element analysis), environmental biology, pollution control and photobiology. (author). 15 refs., 9 figs

  8. DOE Patents Available for Licensing

    International Nuclear Information System (INIS)

    Stuber, C.

    1981-01-01

    DOE Patents Available for Licensing (DOE PAL) provides abstracting and indexing coverage of the DOE patent literature, including patent applications, that concerns any apsect of energy production, conservation, and utilization. The citations are arranged by subject category. DOE is prepared to grant exclusive or nonexclusive, revocable licenses under DOE-owned US patents and patent applications in accordance with the provisions of 10CFR781

  9. A novel POSS-coated quantum dot for biological application

    Directory of Open Access Journals (Sweden)

    Rizvi SB

    2012-08-01

    Full Text Available Sarwat B Rizvi,1 Lara Yildirimer,1 Shirin Ghaderi,1 Bala Ramesh,1 Alexander M Seifalian,1,2 Mo Keshtgar1,21UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, United Kingdom; 2Royal Free Hampstead NHS Trust Hospital, London, United KingdomAbstract: Quantum dots (QDs are fluorescent semiconductor nanocrystals that have the potential for major advancements in the field of nanomedicine through their unique photophysical properties. They can potentially be used as fluorescent probes for various biomedical imaging applications, including cancer localization, detection of micrometastasis, image guided surgery, and targeted drug delivery. Their main limitation is toxicity, which requires a biologically compatible surface coating to shield the toxic core from the surrounding environment. However, this leads to an increase in QD size that may lead to problems of excretion and systemic sequestration. We describe a one pot synthesis, characterization, and in vitro cytotoxicity of a novel polyhedral oligomeric silsesquioxane (POSS-coated CdTe-cored QD using mercaptosuccinic acid (MSA and D-cysteine as stabilizing agents. Characterization was performed using transmission electron microscopy Fourier transform infrared spectroscopy, and photoluminescence studies. POSS-coated QDs demonstrated high colloidal stability and enhanced photostability on high degrees of ultraviolet (UV excitation compared to QDs coated with MSA and D-cysteine alone (P value < 0.05. In vitro toxicity studies showed that both POSS and MSA-QDs were significantly less toxic than ionized salts of Cd+2 and Te-2. Confocal microscopy confirmed high brightness of POSS-QDs in cells at both 1 and 24 hours, indicating that these QDs are rapidly taken up by cells and remain photostable in a biological environment. We therefore conclude that a POSS coating confers biological compatibility, photostability, and colloidal

  10. Challenges of SMR licensing practices

    Energy Technology Data Exchange (ETDEWEB)

    Soderholm, K., E-mail: kristiina.soderholm@fortum.com [Fortum Power, Espoo (Finland)

    2012-12-15

    This paper aims to increase the understanding of high level Nuclear Power Plant (NPP) licensing processes in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their different licensing processes and recent actions in new NPP construction. After discussing their similarities and differences, suitable features for Small Modular Reactor licensing can be emphasized and suggested. Some of the studied licensing processes have elements that are already quite well suited for application to SMRs, but all of these different national processes can benefit from studying and implementing lessons learned from SMR specific licensing needs. The main SMR features to take into account in licensing are standardization of the design, modularity, mass production and serial construction. Modularity can be divided into two different categories: the first category is simply a single unit facility constructed of independently engineered modules (e.g., construction process for Westinghouse AP-1000 NPP) and the second is a facility structure composed of many reactor modules where modules are manufactured in factories and installed into the facility as needed (e.g., NuScale Power SMR design). Short construction schedules will not be fully benefited from if the long licensing process prolongs the commissioning and approach to full-power operation. The focus area of this study is to better understand the possibility of SMR deployment in small nuclear countries, such as Finland, which currently has four operating NPPs. The licensing process needs to be simple and clear to make SMR deployment feasible from an economical point of view. This paper uses public information and interviews with experts to establish the overview of the different licensing processes and their main steps. A high-level comparison of the licensing steps has been carried out. Certain aspects of the aviation industry licensing process have also been studied and certain

  11. Application of the New Decommissioning Regulation to the Nuclear Licensed Facilities (NLF) at Fontenay-aux-Roses's Nuclear Center (CEA)

    International Nuclear Information System (INIS)

    Sauret, Josiane; Piketty, Laurence; Jeanjacques, Michel

    2008-01-01

    This abstract describes the application of the new decommissioning regulation on all Nuclear Licensed Facilities (NLF is to say INB in French) at Fontenay-aux-Roses's Center (CEA/FAR). The decommissioning process has been applied in six buildings which are out of the new nuclear perimeter proposed (buildings no 7, no 40, no 94, no 39, no 52/1 and no 32) and three buildings have been reorganized (no 54, no 91 and no 53 instead of no 40 and no 94) in order to increase the space for temporary nuclear waste disposal and to reduce the internal transports of nuclear waste on the site. The advantages are the safety and radioprotection improvements and a lower operating cost. A global safety file was written in 2002 and 2003 and was sent to the French Nuclear Authority on November 2003. The list of documents required is given in the paragraph I of this paper. The main goals were two ministerial decrees (one decree for each NLF) getting the authorization to modify the NLF perimeter and to carry out cleaning and dismantling activities leading to the whole decommissioning of all NLF. Some specific authorizations were necessary to carry out the dismantling program during the decommissioning procedure. They were delivered by the French Nuclear Safety Authority (FNSA) or with limited delegation by the General Executive Director (GED) on the CEA Fontenay-aux-Roses's Center, called internal authorization. Some partial dismantling or decontamination examples are given below: - evaporator for the radioactive liquid waste treatment station (building no 53): FNSA authorization: phase realised in 2002/2003. - disposal tanks for the radioactive liquid waste treatment station (building no 53) FNSA authorization: phase realised in 2004, - incinerator for the radioactive solid waste treatment station (building no 07): FNSA authorization: operation realised in 2004, - research equipments in the building no. 54 and building no. 91: internal authorization ; realised in 2005, - sample

  12. Polyhydroyalkanoates: from Basic Research and Molecular Biology to Application

    Directory of Open Access Journals (Sweden)

    Amro Abd alFattah Amara

    2010-09-01

    Full Text Available This review describes the Polyhydroxyalkanoate (PHA, an intracellular biodegradable microbial polymer. PHAs is formed from different types of three hydroxyalkanoic acids monomers, each unit forms an ester bond with the hydroxyl group of the other one and the hydroxyl substituted carbon has R configuration. The C-3 atom in β position is branched with at least one carbon atom in the form of methyl group (C1 to thirteen carbons in the form of tridecyl (C13. This alkyl side chain is not necessarily saturated. PHAs are biosynthesized through regulated pathways by specific enzymes. PHAs are accumulated in bacterial cells from soluble to insoluble form as storage materials inside the inclusion bodies during unbalanced nutrition or to save organisms from reducing equivalents. PHAs are converted again to soluble components by PHAs depolymerases and the degraded materials enter various metabolic pathways. Until now, four classes of enzymes responsible for PHAs polymerization are known. PHAs were well studied regarding their promising applications, physical, chemical and biological properties. PHAs are biodegradable, biocompatible, have good material properties, renewable and can be used in many applications. The most limiting factor in PHAs commercialization is their high cost compared to the petroleum plastics. This review highlights the new knowledge and that established by the pioneers in this field as well as the factors, which affect PHAs commercialization.

  13. Application of the NEI 95-10 methodology in the Rcic system of the Unit-1, to implement the criterions of the license renovation rule; (10 Cfr-54)

    International Nuclear Information System (INIS)

    Diaz, A.; Mendoza, G.; Arganis, C.; Viais, J.; Contreras, A.; Fernandez, G.; Medina, G.

    2012-10-01

    In December of 1991, the US National Regulatory Commission (US NRC) published the 10 Cfr-54, to establish the procedures, criterions and necessary requirements for the license renovation of a nuclear power station. In 1994 the US NRC proposed an amendment to these requirements that basically were centered in the effects of the aging in structures and passive components of long life and in the inclusion of Time Limited Aging Analyses (TLAAs). In a general way, is established that the requester should show to the regulator body that the effects of the aging in structures, systems and components are and will be appropriately negotiated or that the TLAAs has been evaluated for the operation extended period. The NEI 95-10 is a guide document developed by the Nuclear Energy Institute (NEI), to provide a focus accepted to cover the requirements of 10 Cfr-54, offering an efficient process that allows to any requester to complete in a practical way the requirements of the License Renovation Rule and to supplement their solicitude. This work presents the application of this guide to the Reactor Core Insulation Cooling (Rcic) of the Unit 1 of the nuclear power plant of Laguna Verde, elect as pilot system to carry out the application of the 10 Cfr-54 following the recommended methodology by the Industrial Guide for the implementation of the License Renovation Rule. (Author)

  14. 76 FR 7847 - Glenn A. Baxter, Application To Renew License for Amateur Radio Service Station K1MAN

    Science.gov (United States)

    2011-02-11

    ... Renew License for Amateur Radio Service Station K1MAN AGENCY: Federal Communications Commission. ACTION... Service Station K1MAN filed by Glenn A. Baxter should be granted. DATES: The document was mailed to the... Amateur Radio Station K1MAN should be granted. As discussed below, the record before us indicates that...

  15. 77 FR 16278 - License Renewal Application for Indian Point Nuclear Generating Units 2 and 3; Entergy Nuclear...

    Science.gov (United States)

    2012-03-20

    ... contacting the NRC about the availability of information regarding this document. You may access information... the Village of Buchanan, New York. The current operating licenses for IP2 and IP3 expire on September... units of measure; (2) a new thermal study that characterizes the thermal plume of cooling water...

  16. The Monticello license renewal project

    International Nuclear Information System (INIS)

    Clauss, J.M.; Harrison, D.L.; Pickens, T.A.

    1993-01-01

    Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

  17. Introduction to solitons and their applications in physics and biology

    International Nuclear Information System (INIS)

    Peyrard, M.

    1995-01-01

    The response of most of the physical systems to combined excitations is not a simple superposition of their response to individual stimuli. This is particularly true for biological systems in which the nonlinear effects are often the dominant ones. The intrinsic treatment of nonlinearities in mathematical models and physical systems has led to the emergence of the chaos and solitons concepts. The concept of soliton, relevant for systems with many degrees of freedom, provides a new tool in the studies of biomolecules because it has no equivalent in the world of linear excitations. The aim of this lecture is to present the main ideas that underline the soliton concept and to discuss some applications. Solitons are solitary waves, that propagate at constant speed without changing their shape. They are extremely stable to perturbations, in particular to collisions with small amplitude linear waves and with other solitons. Conditions to have solitons and equations of solitons propagation are analysed. Solitons can be divided into two main classes: topological and non-topological solitons which can be found at all scales and in various domains of physics and chemistry. Using simple examples, this paper shows how linear expansions can miss completely essential physical properties of a system. This is particularly characteristic for the pendulum chain example. Soliton theory offers alternative methods. Multiple scale approximations, or expansion on a soliton basis, can be very useful to provide a description of some physical phenomena. Nonlinear energy localization is also a very important concept valid for a large variety of systems. These concepts are probably even more relevant for biological molecules than for solid state physics, because these molecules are very deformable objects where large amplitude nonlinear motions or conformational changes are crucial for function. (J.S.). 14 refs., 9 figs

  18. Dielectric relaxation in biological systems physical principles, methods, and applications

    CERN Document Server

    Feldman, Yuri

    2015-01-01

    This title covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems.

  19. Single-molecule experiments in biological physics: methods and applications.

    Science.gov (United States)

    Ritort, F

    2006-08-16

    I review single-molecule experiments (SMEs) in biological physics. Recent technological developments have provided the tools to design and build scientific instruments of high enough sensitivity and precision to manipulate and visualize individual molecules and measure microscopic forces. Using SMEs it is possible to manipulate molecules one at a time and measure distributions describing molecular properties, characterize the kinetics of biomolecular reactions and detect molecular intermediates. SMEs provide additional information about thermodynamics and kinetics of biomolecular processes. This complements information obtained in traditional bulk assays. In SMEs it is also possible to measure small energies and detect large Brownian deviations in biomolecular reactions, thereby offering new methods and systems to scrutinize the basic foundations of statistical mechanics. This review is written at a very introductory level, emphasizing the importance of SMEs to scientists interested in knowing the common playground of ideas and the interdisciplinary topics accessible by these techniques. The review discusses SMEs from an experimental perspective, first exposing the most common experimental methodologies and later presenting various molecular systems where such techniques have been applied. I briefly discuss experimental techniques such as atomic-force microscopy (AFM), laser optical tweezers (LOTs), magnetic tweezers (MTs), biomembrane force probes (BFPs) and single-molecule fluorescence (SMF). I then present several applications of SME to the study of nucleic acids (DNA, RNA and DNA condensation) and proteins (protein-protein interactions, protein folding and molecular motors). Finally, I discuss applications of SMEs to the study of the nonequilibrium thermodynamics of small systems and the experimental verification of fluctuation theorems. I conclude with a discussion of open questions and future perspectives.

  20. Nanodiamond preparation and surface characterization for biological applications

    Science.gov (United States)

    Woodhams, Ben J.; Knowles, Helena S.; Kara, Dhiren M.; Atatüre, Mete; Bohndiek, Sarah E.

    2017-02-01

    Nanodiamonds contain stable fluorescent emitters and hence can be used for molecular fluorescence imaging and precision sensing of electromagnetic fields. The physical properties of these emitters together with their low reported cytotoxicity make them attractive for biological imaging applications. The controlled application of nanodiamonds for cellular imaging requires detailed understanding of surface chemistry, size ranges and aggregation, as these can all influence cellular interactions. We compared these characteristics for graphitic and oxidized nanodiamonds. Oxidation is generally used for surface functionalization, and was optimized by Thermogravimetric Analysis, achieved by 445+/-5°C heating in air for 5 hours, then confirmed via Raman and Infrared spectroscopies. Size ranges and aggregation were assessed using Atomic Force Microscopy and Dynamic Light Scattering. Biocompatibility in breast cancer cell lines was measured using a proliferation assay. Heating at 445+/-5°C reduced the Raman signal of graphitic carbon (1575 cm-1) as compared to that of diamond (1332 cm-1) from 0.31+/-0.07 Raman intensity units to 0.07+/-0.04. This temperature was substantially below the onset of major mass loss (observed at 535+/-1°C) and therefore achieved cost efficiency, convenience and high yield. Graphitic and oxidized nanodiamonds formed aggregates in water, with a mean particle size of 192+/-4nm and 166+/-2nm at a concentration of 66μg/mL. We then applied the graphitic and oxidized nanodiamonds to cells in culture at 1μg/mL and found no significant change in the proliferation rate (-5+/-2% and -1+/-3% respectively). Nanodiamonds may therefore be suitable for development as a novel transformative tool in the life sciences.