WorldWideScience

Sample records for biological warfare

  1. Biological warfare agents

    Directory of Open Access Journals (Sweden)

    Duraipandian Thavaselvam

    2010-01-01

    Full Text Available The recent bioterrorist attacks using anthrax spores have emphasized the need to detect and decontaminate critical facilities in the shortest possible time. There has been a remarkable progress in the detection, protection and decontamination of biological warfare agents as many instrumentation platforms and detection methodologies are developed and commissioned. Even then the threat of biological warfare agents and their use in bioterrorist attacks still remain a leading cause of global concern. Furthermore in the past decade there have been threats due to the emerging new diseases and also the re-emergence of old diseases and development of antimicrobial resistance and spread to new geographical regions. The preparedness against these agents need complete knowledge about the disease, better research and training facilities, diagnostic facilities and improved public health system. This review on the biological warfare agents will provide information on the biological warfare agents, their mode of transmission and spread and also the detection systems available to detect them. In addition the current information on the availability of commercially available and developing technologies against biological warfare agents has also been discussed. The risk that arise due to the use of these agents in warfare or bioterrorism related scenario can be mitigated with the availability of improved detection technologies.

  2. Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Dev Vrat Kamboj

    2006-10-01

    Full Text Available There is a long historic record of use of biological warfare (BW agents by warring countriesagainst their enemies. However, the frequency of their use has increased since the beginningof the twentieth century. World war I witnessed the use of anthrax agent against human beingsand animals by Germans, followed by large-scale field trials by Japanese against war prisonersand Chinese population during world war II. Ironically, research and development in biologicalwarfare agents increased tremendously after the Geneva Protocol, signed in 1925, because ofits drawbacks which were overcome by Biological and Toxin Weapons Convention (BTWC in1972. Biological warfare programme took back seat after the 1972 convention but biologicalagents regained their importance after the bioterrorist attacks of anthrax powder in 2001. In thelight of these attacks, many of which turned out to be hoax, general awareness is required aboutbiological warfare agents that can be used against them. This review has been written highlightingimportant biological warfare agents, diseases caused by them, possible therapies and otherprotection measures.

  3. Biological warfare, bioterrorism, and biocrime.

    Science.gov (United States)

    Jansen, H J; Breeveld, F J; Stijnis, C; Grobusch, M P

    2014-06-01

    Biological weapons achieve their intended target effects through the infectivity of disease-causing infectious agents. The ability to use biological agents in warfare is prohibited by the Biological and Toxin Weapon Convention. Bioterrorism is defined as the deliberate release of viruses, bacteria or other agents used to cause illness or death in people, but also in animals or plants. It is aimed at creating casualties, terror, societal disruption, or economic loss, inspired by ideological, religious or political beliefs. The success of bioterroristic attempts is defined by the measure of societal disruption and panic, and not necessarily by the sheer number of casualties. Thus, making only a few individuals ill by the use of crude methods may be sufficient, as long as it creates the impact that is aimed for. The assessment of bioterrorism threats and motives have been described before. Biocrime implies the use of a biological agent to kill or make ill a single individual or small group of individuals, motivated by revenge or the desire for monetary gain by extortion, rather than by political, ideological, religious or other beliefs. The likelihood of a successful bioterrorist attack is not very large, given the technical difficulties and constraints. However, even if the number of casualties is likely to be limited, the impact of a bioterrorist attack can still be high. Measures aimed at enhancing diagnostic and therapeutic capabilities and capacities alongside training and education will improve the ability of society to combat 'regular' infectious diseases outbreaks, as well as mitigating the effects of bioterrorist attacks.

  4. Biological warfare, bioterrorism, and biocrime.

    Science.gov (United States)

    Jansen, H J; Breeveld, F J; Stijnis, C; Grobusch, M P

    2014-06-01

    Biological weapons achieve their intended target effects through the infectivity of disease-causing infectious agents. The ability to use biological agents in warfare is prohibited by the Biological and Toxin Weapon Convention. Bioterrorism is defined as the deliberate release of viruses, bacteria or other agents used to cause illness or death in people, but also in animals or plants. It is aimed at creating casualties, terror, societal disruption, or economic loss, inspired by ideological, religious or political beliefs. The success of bioterroristic attempts is defined by the measure of societal disruption and panic, and not necessarily by the sheer number of casualties. Thus, making only a few individuals ill by the use of crude methods may be sufficient, as long as it creates the impact that is aimed for. The assessment of bioterrorism threats and motives have been described before. Biocrime implies the use of a biological agent to kill or make ill a single individual or small group of individuals, motivated by revenge or the desire for monetary gain by extortion, rather than by political, ideological, religious or other beliefs. The likelihood of a successful bioterrorist attack is not very large, given the technical difficulties and constraints. However, even if the number of casualties is likely to be limited, the impact of a bioterrorist attack can still be high. Measures aimed at enhancing diagnostic and therapeutic capabilities and capacities alongside training and education will improve the ability of society to combat 'regular' infectious diseases outbreaks, as well as mitigating the effects of bioterrorist attacks. PMID:24890710

  5. History of chemical and biological warfare agents.

    Science.gov (United States)

    Szinicz, L

    2005-10-30

    Chemical and biological warfare agents constitute a low-probability, but high-impact risk both to the military and to the civilian population. The use of hazardous materials of chemical or biological origin as weapons and for homicide has been documented since ancient times. The first use of chemicals in terms of weapons of mass destruction goes back to World War I, when on April 22, 1915 large amounts of chlorine were released by German military forces at Ypres, Belgium. Until around the 1970s of the 20th century, the awareness of the threat by chemical and biological agents had been mainly confined to the military sector. In the following time, the development of increasing range delivery systems by chemical and biological agents possessors sensitised public attention to the threat emanating from these agents. Their proliferation to the terrorists field during the 1990s with the expanding scale and globalisation of terrorist attacks suggested that these agents are becoming an increasing threat to the whole world community. The following article gives a condensed overview on the history of use and development of the more prominent chemical and biological warfare agents. PMID:16111798

  6. History of biological warfare and bioterrorism.

    Science.gov (United States)

    Barras, V; Greub, G

    2014-06-01

    Bioterrorism literally means using microorganisms or infected samples to cause terror and panic in populations. Bioterrorism had already started 14 centuries before Christ, when the Hittites sent infected rams to their enemies. However, apart from some rare well-documented events, it is often very difficult for historians and microbiologists to differentiate natural epidemics from alleged biological attacks, because: (i) little information is available for times before the advent of modern microbiology; (ii) truth may be manipulated for political reasons, especially for a hot topic such as a biological attack; and (iii) the passage of time may also have distorted the reality of the past. Nevertheless, we have tried to provide to clinical microbiologists an overview of some likely biological warfare that occurred before the 18th century and that included the intentional spread of epidemic diseases such as tularaemia, plague, malaria, smallpox, yellow fever, and leprosy. We also summarize the main events that occurred during the modern microbiology era, from World War I to the recent 'anthrax letters' that followed the World Trade Center attack of September 2001. Again, the political polemic surrounding the use of infectious agents as a weapon may distort the truth. This is nicely exemplified by the Sverdlovsk accident, which was initially attributed by the authorities to a natural foodborne outbreak, and was officially recognized as having a military cause only 13 years later. PMID:24894605

  7. History of biological warfare and bioterrorism.

    Science.gov (United States)

    Barras, V; Greub, G

    2014-06-01

    Bioterrorism literally means using microorganisms or infected samples to cause terror and panic in populations. Bioterrorism had already started 14 centuries before Christ, when the Hittites sent infected rams to their enemies. However, apart from some rare well-documented events, it is often very difficult for historians and microbiologists to differentiate natural epidemics from alleged biological attacks, because: (i) little information is available for times before the advent of modern microbiology; (ii) truth may be manipulated for political reasons, especially for a hot topic such as a biological attack; and (iii) the passage of time may also have distorted the reality of the past. Nevertheless, we have tried to provide to clinical microbiologists an overview of some likely biological warfare that occurred before the 18th century and that included the intentional spread of epidemic diseases such as tularaemia, plague, malaria, smallpox, yellow fever, and leprosy. We also summarize the main events that occurred during the modern microbiology era, from World War I to the recent 'anthrax letters' that followed the World Trade Center attack of September 2001. Again, the political polemic surrounding the use of infectious agents as a weapon may distort the truth. This is nicely exemplified by the Sverdlovsk accident, which was initially attributed by the authorities to a natural foodborne outbreak, and was officially recognized as having a military cause only 13 years later.

  8. Cutaneous reactions in nuclear, biological and chemical warfare

    Directory of Open Access Journals (Sweden)

    Arora Sandeep

    2005-03-01

    Full Text Available Nuclear, biological and chemical warfare have in recent times been responsible for an increasing number of otherwise rare dermatoses. Many nations are now maintaining overt and clandestine stockpiles of such arsenal. With increasing terrorist threats, these agents of mass destruction pose a risk to the civilian population. Nuclear and chemical attacks manifest immediately while biological attacks manifest later. Chemical and biological attacks pose a significant risk to the attending medical personnel. The large scale of anticipated casualties in the event of such an occurrence would need the expertise of all physicians, including dermatologists, both military and civilian. Dermatologists are uniquely qualified in this respect. This article aims at presenting a review of the cutaneous manifestations in nuclear, chemical and biological warfare and their management.

  9. Biological warfare agents as threats to potable water.

    OpenAIRE

    Burrows, W D; Renner, S E

    1999-01-01

    Nearly all known biological warfare agents are intended for aerosol application. Although less effective as potable water threats, many are potentially capable of inflicting heavy casualties when ingested. Significant loss of mission capability can be anticipated even when complete recovery is possible. Properly maintained field army water purification equipment can counter this threat, but personnel responsible for the operation and maintenance of the equipment may be most at risk of exposur...

  10. Refocusing NATO's intelligence outlook towards biological warfare

    OpenAIRE

    Villareal, Claro William.

    1996-01-01

    Approved for public release; distribution is unlimited Today, we are attempting to manage chaos. With the end of the Cold War, a number of troubling developments in the world have been unleashed, especially the proliferation of WMD. Biological weapons are an increasing threat to world security. Nations and non-state actors are willing to sell or buy the necessary technologies for the production of biological weapons which can have disastrous effects on a military, an economy, and the envir...

  11. [Biological warfare and terror: prevention and countermeasures].

    Science.gov (United States)

    Hansen, John-Erik Stig

    2010-01-11

    Biological weapons are the most commonly used weapons of mass destruction. Serious international concerns exist about their use by non-state actors, and such use is facilitated by developments in biotechnology. In Denmark, counter-proliferation is served by a new biosecurity act and the establishment of a new biosecurity authority. Aspects of biopreparedness have also been strengthened. International collaboration is necessary in order to enhance both the security measures aimed at avoiding the misuse of science but also to enhance societal resilience if potentially devastating biological attacks should occur. PMID:20074489

  12. A short history of biological warfare.

    Science.gov (United States)

    Metcalfe, Neil

    2002-01-01

    Biological weapons have been used in war from the start of recorded history. This article reviews the history of the subject, including the outbreak of the Black Death and the use of smallpox against American Indians. The new science of microbiology was misused from soon after its start and, despite the 1925 Geneva Protocol, the Japanese experimented extensively on prisoners in China. The Allies carried out extensive research during the Second World War, notably the United Kingdom into anthrax on Gruinard Island and the United States into a variety of agents. Despite the 1972 Biological Weapons Convention (BWC), a major programme continued in the former Soviet Union (leading to an accidental outbreak of anthrax). Most recently Iraq was revealed as having an extensive programme, with weaponization of large amounts of various agents, and several terrorists groups have attempted to use biological agents as weapons. Modern developments in biotechnology could lead to even more serious developments, and effective preventive measures, including strengthening of the BWC, are imperative. PMID:12201085

  13. A short history of biological warfare.

    Science.gov (United States)

    Metcalfe, Neil

    2002-01-01

    Biological weapons have been used in war from the start of recorded history. This article reviews the history of the subject, including the outbreak of the Black Death and the use of smallpox against American Indians. The new science of microbiology was misused from soon after its start and, despite the 1925 Geneva Protocol, the Japanese experimented extensively on prisoners in China. The Allies carried out extensive research during the Second World War, notably the United Kingdom into anthrax on Gruinard Island and the United States into a variety of agents. Despite the 1972 Biological Weapons Convention (BWC), a major programme continued in the former Soviet Union (leading to an accidental outbreak of anthrax). Most recently Iraq was revealed as having an extensive programme, with weaponization of large amounts of various agents, and several terrorists groups have attempted to use biological agents as weapons. Modern developments in biotechnology could lead to even more serious developments, and effective preventive measures, including strengthening of the BWC, are imperative.

  14. Evanescent planar waveguide detection of biological warfare simulants

    Science.gov (United States)

    Sipe, David M.; Schoonmaker, Kenneth P.; Herron, James N.; Mostert, Michael J.

    2000-04-01

    An evanescent planar waveguide Mark 1.5 instrument was used to detect simulants of biological warfare agents; ovalbumin (OV), MS2 bacteriophage, BG, and Erwinia herbicola (EH). Polyclonal tracer antibodies were labeled with the fluorescent dye, Cy5. Discrete bands of polyclonal capture antibodies were immobilized to a polystyrene planar waveguide with molded integral lenses. An ST-6 CCD camera was used for detection. OV. MS2 and BG were detected in a simultaneous 3 by 3 array; with a total of nine measurements within 6 minutes. EH was analyzed in a separate array. Results were evaluate dat the US Army Joint Field Trials V, at the Dugway Proving Grounds. Over a 10 day period, 32 unknown samples were analyzed daily for each simulant. Detection limits: OV 10 ng/ml, MS2 107 pfu/ml, BG 105 cfu/ml. EH was detectable at 5 X 105 cfu/ml. Overall false positives were 3.0 percent. Therefore, the Mark 1.5 instrument, with a parallel array of detectors, evanescent flourescent excitation, and CCD imaging provides for rapid, sensitive, and specific detection of biological warfare agent simulants.

  15. Looming Threat of Chemical and Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    A.K. Goel

    2016-09-01

    Full Text Available In the recent past, a dramatic shift has been observed in the strategies of warfare from conventional to non-conventional. Now-a-days, traditional power is of less importance than it used to be earlier. Weapons of mass destruction, which comprise of nuclear weapons, and chemical and biological warfare agents, are posing a great peril to the world due to their devastating potential. Though, there are several bilateral as well as multilateral treaties to control the use and proliferation of these weapons, yet the risk of use of such agents by non-state actors cannot be overlooked. Chances of use of chemical and biological agents are more likely than the nuclear weapons. A comparison of nuclear, chemical and biological weapons in terms of technology, cost, signature, effectiveness on protected and un-protected troops shows that chemical and biological weapon programmes require much lower level of technology and cost than the nuclear weapon programme. Further, there is no or least distinctive and readily observable signature in biological weapon programme in comparison to nuclear and chemical weapon facilities. There can be two possibilities of use of these agents in terrorist attacks. First, there is a risk of transfer of material or know-how of these weapons to terrorists for using against the adversaries and second, the risk of these agents being pilfered due to poor security, thereby sabotaging the national security. The International Committee of Red Cross in February 1918 reckoned these agents as ‘barbarous inventions’ that can ‘only be called criminal’.

  16. Chemical and biological warfare: General studies. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The bibliography contains citations concerning federally sponsored and conducted studies into chemical and biological warfare operations and planning. These studies cover areas not addressed in other parts of this series. The topics include production and storage of agents, delivery techniques, training, military and civil defense, general planning studies, psychological reactions to chemical warfare, evaluations of materials exposed to chemical agents, and studies on banning or limiting chemical warfare. Other published searches in this series on chemical warfare cover detection and warning, defoliants, protection, and biological studies, including chemistry and toxicology. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  17. Chemical and biological warfare: General studies. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The bibliography contains citations concerning federally sponsored and conducted studies into chemical and biological warfare operations and planning. These studies cover areas not addressed in other parts of this series. The topics include production and storage of agents, delivery techniques, training, military and civil defense, general planning studies, psychological reactions to chemical warfare, evaluations of materials exposed to chemical agents, and studies on banning or limiting chemical warfare. Other published searches in this series on chemical warfare cover detection and warning, defoliants, protection, and biological studies, including chemistry and toxicology.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  18. LIDAR for Detection of Chemical and Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    S Veerabuthiran

    2011-04-01

    Full Text Available Remote detection of chemical and biological warfare agents and toxic gases in the atmosphere is of current interest to both the military and civilian agencies. Out of all currently available techniques, no single technique provides efficient detection against such threats at significant standoff distances. Light detection and ranging (LIDAR technologies, based on the transmission of laser pulses and analysis of the return signals, have demonstrated impressive capabilities in remote detection of such toxic chemicals. LIDAR is a highly sensitive tool to detect the extremely low concentrations of various toxic agents present in the form of thin clouds at distances of few kilometer. The detection of these toxic clouds is based on the approach of first detecting and measuring the range of the clouds using the scattering phenomena and subsequently identifying the composition of toxic clouds using absorption and fluorescence phenomena. Laser Science and Technology Centre (LASTEC, Delhi has been working on the design and development of LIDAR systems for detection of chemical and biological warfare (CBW agents. In this paper, theoretical analysis of differential absorption LIDAR (DIAL for detection of chemical agents and fluorescence LIDAR for detection of biological agents has been discussed. For some typical parametric conditions, the received power levels from different ranges to detect specific concentrations of chemical or biological clouds have been computed and discussed. The technical details of the indigenously developed backscattering LIDAR, which detects and measures the distance of cloud layers up to 5 km is also presented.Defence Science Journal, 2011, 61(3, pp.241-250, DOI:http://dx.doi.org/10.14429/dsj.61.556

  19. Respiratory Protection Against Chemical and Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    G.K. Prasad

    2008-09-01

    Full Text Available Chemical and biological warfare (CBW agents pose unavoidable threat, both to soldiers and civilians.Exposure to such deadly agents amidst the CBW agents contaminated environment can be avoided bytaking proper protective measures. Respiratory protection is indispensable when the soldiers or civiliansare surrounded by such deadly environment as contamination-free air is needed for respiration purposes.In this context, an attempt has been made to review the literature for the past five decades on developmentof various protective devices for respiratory protection against aerosols, gases, and vapours of CBWagents. This review covers structural, textural, and adsorption properties of materials used in gas filtersand mechanical filters for the removal of CBW agents.Defence Science Journal, 2008, 58(5, pp.686-697, DOI:http://dx.doi.org/10.14429/dsj.58.1692

  20. Lessons learned from the former Soviet biological warfare program

    Science.gov (United States)

    Anderson, Debra A.

    The purpose of this doctoral project was to develop the most credible educational tool openly available to enhance the understanding and the application of biological weapons threat analysis. The theory governing the effectiveness of biological weapons was integrated from publications, lectures, and seminars primarily provided by Kenneth Alibek and William C. Patrick III, the world's foremost authorities on the topic. Both experts validated the accuracy of the theory compiled from their work and provided forewords. An exercise requiring analysis of four national intelligence estimates of the former Soviet biological warfare program was included in the form of educational case studies to enhance retention, experience, and confidence by providing a platform against which the reader can apply the newly learned theory. After studying the chapters on BW theory, the reader can compare his/her analysis of the national intelligence estimates against the analysis provided in the case studies by this researcher. This training aid will be a valuable tool for all who are concerned with the threat posed by biological weapons and are therefore seeking the most reliable source of information in order to better understand the true nature of the threat.

  1. Biological toxin warfare: threat, proliferation, and the effects of neutron energy on BTW agents

    OpenAIRE

    Swartz, Jeffrey R.

    1995-01-01

    The threat of biological weapons presents a special military challenge. Biological toxin warfare (BTW) agents are more potent than chemical warfare agents. Depending on the yield of the nuclear weapon, a biological weapon also can have a higher lethality than nuclear weapons. This thesis examines existing international restricions on the proliferation of BTW technology and identifies their shortcomings. These loopholes contribute to the eay availability of the technology necessary to examine ...

  2. Detection of biological warfare agents using ultra violet-laser induced fluorescence LIDAR

    Science.gov (United States)

    Joshi, Deepti; Kumar, Deepak; Maini, Anil K.; Sharma, Ramesh C.

    This review has been written to highlight the threat of biological warfare agents, their types and detection. Bacterial biological agent Bacillus anthracis (bacteria causing the disease anthrax) which is most likely to be employed in biological warfare is being discussed in detail. Standoff detection of biological warfare agents in aerosol form using Ultra violet-Laser Induced Fluorescence (UV-LIF) spectroscopy method has been studied. Range-resolved detection and identification of biological aerosols by both nano-second and non-linear femto-second LIDAR is also discussed. Calculated received fluorescence signal for a cloud of typical biological agent Bacillus globigii (Simulants of B. anthracis) at a location of ˜5.0 km at different concentrations in presence of solar background radiation has been described. Overview of current research efforts in internationally available working UV-LIF LIDAR systems are also mentioned briefly.

  3. The United States and biological warfare: secrets from the early cold war and Korea.

    Science.gov (United States)

    Bruwer, A

    2001-01-01

    The United States and Biological Warfare is about accusations that the United States resorted to bacteriological warfare at a time of great military stress during the Korean War. In December 1951, the then US Secretary of Defense ordered early readiness for offensive use of biological weapons. Soon afterwards, the North Korean and Chinese armies accused the United States of starting a large-scale biological warfare experiment in Korea. The US State Department denied the accusation. Both parties to the dispute maintain their positions today. The authors spent 20 years researching the accusations in North America, Europe and Japan. They were the first foreigners to be given access to Chinese classified documents. The reader is also introduced to the concept of 'plausible denial', an official US policy which allowed responsible governmental representatives to deny knowledge of certain events. The authors hope that their work will contribute to the understanding of a time when modern war expanded into a new type of violence.

  4. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  5. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  6. [Glanders--a potential disease for biological warfare in humans and animals].

    Science.gov (United States)

    Lehavi, Ofer; Aizenstien, Orna; Katz, Lior H; Hourvitz, Ariel

    2002-05-01

    Infection with Burkholderia mallei (formerly Pseudomonas mallei) can cause a subcutaneous infection known as "farcy" or can disseminate to condition known as Glanders. It is primarily a disease affecting horses, donkeys and mules. In humans, Glanders can produce four types of disease: localized form, pulmonary form, septicemia, and chronic form. Necrosis of the tracheobronchial tree and pustular skin lesions characterize acute infection with B. mallei. Other symptoms include febrile pneumonia, if the organism was inhaled, or signs of sepsis and multiple abscesses, if the skin was the port of entry. Glanders is endemic in Africa, Asia, the Middle East, and Central and South America. Glanders has low contiguous potential, but because of the efficacy of aerosolized dissemination and the lethal nature of the disease, B. mallei was considered a candidate for biological warfare. During World War I, Glanders was believed to have been spread to infect large numbers of Russian horses and mules on the Eastern front. The Japanese infected horses, civilians and prisoners of war during World War II. The USA and the Soviet Union have shown interest in B. mallei in their biological warfare program. The treatment is empiric and includes mono or poly-therapy with Ceftazidime, Sulfadiazine, Trimethoprim + Sulfamethoxazol, Gentamicin, Imipenem etc. Aggressive control measures essentially eliminated Glanders from the west. However, with the resurgent concern about biological warfare, B. mallei is now being studied in a few laboratories worldwide. This review provides an overview of the disease and presents the only case reported in the western world since 1949.

  7. Terahertz signatures of biological-warfare-agent simulants

    Science.gov (United States)

    Globus, Tatiana; Woolard, Dwight L.; Khromova, Tatyana; Partasarathy, Ramakrishnan; Majewski, Alexander; Abreu, Rene; Hesler, Jeffrey L.; Pan, Shing-Kuo; Ediss, Geoff

    2004-09-01

    This work presents spectroscopic characterization results for biological simulant materials measured in the terahertz gap. Signature data have been collected between 3 cm-1 and 10 cm-1 for toxin Ovalbumin, bacteria Erwinia herbicola, Bacillus Subtilis lyophilized cells and RNA MS2 phage, BioGene. Measurements were conducted on a modified Bruker FTIR spectrometer equipped with the noise source developed in the NRAL. The noise source provides two orders of magnitude higher power in comparison with a conventional mercury lamp. Photometric characterization of the instrument performance demonstrates that the expected error for sample characterization inside the interval from 3 to 9.5 cm-1 is less then 1%.

  8. Chemiluminescence assay for the detection of biological warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Langry, K; Horn, J

    1999-11-05

    A chemiluminescent homogeneous immunoassay and a hand-size multiassay reader are described that could be used for detecting biological materials. The special feature of the assay is that it employs two different antibodies that each bind to a unique epitope on the same antigen. Each group of epitope-specific antibodies has linked to it an enzyme of a proximal-enzyme pair. One enzyme of the pair utilizes a substrate in high concentration to produce a second substrate required by the second enzyme. This new substrate enables the second enzyme to function. The reaction of the second enzyme is configured to produce light. This chemiluminescence is detected with a charge-coupled device (CCD) camera. The proximal pair enzymes must be in close proximity to one another to allow the second enzyme to react with the product of the first enzyme. This only occurs when the enzyme-linked antibodies are attached to the antigen, whether antigen is a single protein with multiple epitopes or the surface of a cell with a variety of different antigens. As a result of their juxtaposition, the enzymes produce light only in the presence of the biological material. A brief description is given as to how this assay could be utilized in a personal bio-agent detector system.

  9. Selfishness, warfare, and economics; or integration, cooperation, and biology.

    Science.gov (United States)

    Salvucci, Emiliano

    2012-01-01

    The acceptance of Darwin's theory of evolution by natural selection is not complete and it has been pointed out its limitation to explain the complex processes that constitute the transformation of species. It is necessary to discuss the explaining power of the dominant paradigm. It is common that new discoveries bring about contradictions that are intended to be overcome by adjusting results to the dominant reductionist paradigm using all sorts of gradations and combinations that are admitted for each case. In addition to the discussion on the validity of natural selection, modern findings represent a challenge to the interpretation of the observations with the Darwinian view of competition and struggle for life as theoretical basis. New holistic interpretations are emerging related to the Net of Life, in which the interconnection of ecosystems constitutes a dynamic and self-regulating biosphere: viruses are recognized as a macroorganism with a huge collection of genes, most unknown that constitute the major planet's gene pool. They play a fundamental role in evolution since their sequences are capable of integrating into the genomes in an "infective" way and become an essential part of multicellular organisms. They have content with "biological sense" i.e., they appear as part of normal life processes and have a serious role as carrier elements of complex genetic information. Antibiotics are cell signals with main effects on general metabolism and transcription on bacterial cells and communities. The hologenome theory considers an organism and all of its associated symbiotic microbes (parasites, mutualists, synergists, amensalists) as a result of symbiopoiesis. Microbes, helmints, that are normally understood as parasites are cohabitants and they have cohabited with their host and drive the evolution and existence of the partners. Each organism is the result of integration of complex systems. The eukaryotic organism is the result of combination of bacterial

  10. Bioterrorism and Biological Warfare, from Past to the Present: A classic review

    Directory of Open Access Journals (Sweden)

    Majid Zare Bidaki

    2015-10-01

    Full Text Available Bioterrorism is defined as any terrorist action of intentional release or dissemination of highly pathogenic biological agents, including a variety of microorganisms or biological toxins. With the growing threat of terrorism, is necessary that the potential danger of various microorganisms – as a powerful tool of aggression and threat- to be taken seriously. This review tries to explain the concept of biological weapons and their historical development process with an emphasis on efforts to control the proliferation of these types of weapons over the last century. Potential impact of infectious diseases on people and armed forces was known from since 600 BC. Using the victims of the plague as a weapon in medieval warfare and spread of smallpox as a weapon during the war against the Indians when initially America was discovered, the development of biological weapons during the World War I, World War II and the Cold War, and even since the beginning of the third millennium, all show the strategic importance of pathogenic microorganisms as a deterrent power for the superiority of some governments and cults. Historical attempts to use infectious diseases as biological weapons reveal that the distinction between a natural outbreak of an infectious disease and that of a deliberate biological attack is very difficult. Abusing this characteristic of infectious diseases has made it possible for the purposes of superiority. International agreements to control the development of biological weapons, such as “the 1925 Geneva Protocol” and “the Convention on the Prohibition of the Development, Production and Stockpiling of Biological and Toxic Weapons” have not been able to control the development and using of biological warfare.  The current paper is a classic review (Overview article aiming at increasing the knowledge and awareness of people especially of health authorities and government officials.

  11. Love-Wave Sensors Combined with Microfluidics for Fast Detection of Biological Warfare Agents

    OpenAIRE

    Daniel Matatagui; José Luis Fontecha; María Jesús Fernández; Isabel Gràcia; Carles Cané; José Pedro Santos; María Carmen Horrillo

    2014-01-01

    The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentr...

  12. Chemical and biological warfare: Detection and warning systems. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The bibliography contains citations concerning the detection, identification, verification, and warning systems of chemical and biological warfare agents. Citations discuss agents sampling, monitoring, and assessment. Techniques include chromotography, biosensing, chemical analysis, and DNA probes. Land pollution, soil tests, and skin protection are examined. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  13. Love-Wave Sensors Combined with Microfluidics for Fast Detection of Biological Warfare Agents

    Science.gov (United States)

    Matatagui, Daniel; Fontecha, José Luis; Fernández, María Jesús; Gràcia, Isabel; Cané, Carles; Santos, José Pedro; Horrillo, María Carmen

    2014-01-01

    The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13), and the rabbit immunoglobulin (Rabbit IgG) has been detected using the polyclonal antibody goat anti-rabbit (GAR). Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved. PMID:25029282

  14. Love-Wave Sensors Combined with Microfluidics for Fast Detection of Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Daniel Matatagui

    2014-07-01

    Full Text Available The following paper examines a time-efficient method for detecting biological warfare agents (BWAs. The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13, and the rabbit immunoglobulin (Rabbit IgG has been detected using the polyclonal antibody goat anti-rabbit (GAR. Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved.

  15. Love-wave sensors combined with microfluidics for fast detection of biological warfare agents.

    Science.gov (United States)

    Matatagui, Daniel; Fontecha, José Luis; Fernández, María Jesús; Gràcia, Isabel; Cané, Carles; Santos, José Pedro; Horrillo, María Carmen

    2014-01-01

    The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13), and the rabbit immunoglobulin (Rabbit IgG) has been detected using the polyclonal antibody goat anti-rabbit (GAR). Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved. PMID:25029282

  16. Chemical and Biological Warfare: Should Rapid Detection Techniques Be Researched To Dissuade Usage? A Review

    Directory of Open Access Journals (Sweden)

    Mark R. Hurst

    2005-01-01

    Full Text Available Chemistry, microbiology and genetic engineering have opened new doorways for the human race to propel itself to a better future. However, there is a darker side to Bioengineering. One element of this is the manufacture and proliferation of biological and chemical weapons. It is clearly in the interest of humankind to prevent the future use of such weapons of mass destruction. Though many agents have been proposed as potential biological and chemical weapons, the feasibility of these weapons is a matter of conjecture. The unpredictable and indiscriminate devastation caused by natural epidemics and hazardous chemicals during wartime without medical treatment should warn humans of the dangers of employing them as weapons. This study argues rapid detection techniques may dissuade future use. Many agents are far less toxic to treatment. A quick response time to most attacks will decrease the chances of serious health issues. The agent will be less effective and discourage the attacker from using the weapon. Fortunately, the Chemical and Biological Weapons Convention (CWCIBWC allows defensive work in the area of biological and chemical weapons. Consequently, the review will discuss history, delivery/dispersal systems and specific agents of the warfare. The study presents current developments in biosensors for toxic materials of defense interest. It concludes with future directions for biosensor development.

  17. Chemical and biological warfare: Protection, decontamination, and disposal. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The bibliography contains citations concerning the means to defend against chemical and biological agents used in military operations, and to eliminate the effects of such agents on personnel, equipment, and grounds. Protection is accomplished through protective clothing and masks, and in buildings and shelters through filtration. Elimination of effects includes decontamination and removal of the agents from clothing, equipment, buildings, grounds, and water, using chemical deactivation, incineration, and controlled disposal of material in injection wells and ocean dumping. Other Published Searches in this series cover chemical warfare detection; defoliants; general studies; biochemistry and therapy; and biology, chemistry, and toxicology associated with chemical warfare agents.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  18. Chemical and biological warfare: Protection, decontamination, and disposal. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The bibliography contains citations concerning the means to defend against chemical and biological agents used in military operations, and to eliminate the effects of such agents on personnel, equipment, and grounds. Protection is accomplished through protective clothing and masks, and in buildings and shelters through filtration. Elimination of effects includes decontamination and removal of the agents from clothing, equipment, buildings, grounds, and water, using chemical deactivation, incineration, and controlled disposal of material in injection wells and ocean dumping. Other Published Searches in this series cover chemical warfare detection; defoliants; general studies; biochemistry and therapy; and biology, chemistry, and toxicology associated with chemical warfare agents. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  19. Modified clay minerals efficiency against chemical and biological warfare agents for civil human protection.

    Science.gov (United States)

    Plachá, Daniela; Rosenbergová, Kateřina; Slabotínský, Jiří; Kutláková, Kateřina Mamulová; Studentová, Soňa; Martynková, Gražyna Simha

    2014-04-30

    Sorption efficiencies of modified montmorillonite and vermiculite of their mono ionic Na and organic HDTMA and HDP forms were studied against chemical and biological warfare agents such as yperite and selected bacterial strains. Yperite interactions with modified clay minerals were observed through its capture in low-density polyethylene foil-modified clay composites by measuring yperite gas permeation with using chemical indication and gas chromatography methods. The antibacterial activities of synthetized organoclays were tested against selected Gram-positive and Gram-negative bacterial species in minimum inhibitory concentration tests. The obtained results showed a positive influence of modified clay minerals on the significant yperite breakthrough-time increase. The most effective material was the polyethylene-Na form montmorillonite, while the polyethylene-Na form vermiculite showed the lowest efficiency. With increasing organic cations loading in the interlayer space the montmorillonite efficiency decreased, and in the case of vermiculite an opposite effect was observed. Generally the modified montmorillonites were more effective than modified vermiculites. The HDP cations seem to be more effective compare to the HDTMA. The antibacterial activity tests confirmed efficiency of all organically modified clay minerals against Gram-positive bacteria. The confirmation of antibacterial activity against Y. pestis, plague bacteria, is the most interesting result of this part of the study.

  20. Stem-loop oligonucleotide beacons as switches for amplifying-fluorescent-polymer-based biological warfare sensors

    Science.gov (United States)

    Clinkenbeard, Kenneth D.; Ramachandran, Akhilesh; Malayer, Jerry R.; Moon, Joong Ho; Hancock, Lawrence F.

    2003-09-01

    Sensors that are exceptionally sensitive with real-time outputs and minimal consumption of reagents are needed to continuously monitor air and water against bioterrorist incidents. Amplifying fluorescent polymers (AFP) provide exceptionally sensitive real-time reagentless sensor platforms as applied to detection of nitroaromatic explosives. This platform technology has the potential to be adapted to detect biological warfare (BW) agents by covalently attaching the 5" end of stem-loop molecular beacons to AFP as DNA hybridization signal transduction switches. Molecular beacons with loop sequences specific for sequence signatures of a target BW agent are configured with a quencher on the end of the 3" arm of the stem-loop. The AFP is quenched in the absence of target DNA, but upon hybridization with target the stem is melted, the duplex loop extended, and the AFP dequenched. This signal transduction is reversible upon removal of the target sequence with the molecular beacon reforming the stem-loop conformation. Proof-of-concept research has demonstrated that molecular beacons for signature sequences of Francisella tularensis result in correct identification of the presence of this agent in samples, but no false positives were seen with Escherichia coli.

  1. Detection of biological warfare agents with fiber-optic microsphere-based DNA arrays

    Science.gov (United States)

    Song, Linan; Walt, David R.

    2005-11-01

    Biological warfare agents (BWAs) pose significant threats to both military forces and civilian populations. The increased concern about bioterrorism has promoted the development of rapid, sensitive, and reliable detection systems to provide an early warning for detecting the release of BWAs. We have developed a high-density DNA array to detect BWAs in real environmental samples with fast response times and high sensitivity. An optical fiber bundle containing approximately 50,000 individual 3.1 μm diameter fibers was chemically etched to yield an array of microwells and used as the substrate for the array. 50-mer single-stranded DNA probes designed to be specific for target BWAs were covalently attached to 3.1-μm microspheres, and the microspheres were distributed into the microwells to form a randomized high-density DNA array. We demonstrated the applicability of this DNA array for the identification of Bacillus thuringiensis kurstaki, a BWA simulant, in real samples. PCR was used to amplify the sequences, introduce fluorescent labels into the target molecules, and provide a second level of specificity. After hybridization of test solutions to the array, analysis was performed by evaluating the specific responses of individual probes on the array.

  2. Chemical and biological warfare: Biochemistry, therapy, and treatment. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The bibliography contains citations concerning biochemistry, therapy, and treatment of the effects of military chemical and biological warfare agents. References include surveys and studies of immunizing agents and drugs, the efficacy of these drugs, and the effect of the drugs on the patient. Also included are biochemical studies, assay techniques, and antidote development, some of which is supported by animal studies. Citations concerning detection and warning, defoliants, protection, biology and toxicology, and general studies are covered in separate bibliographies.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  3. Chemical and biological warfare: Biochemistry, therapy, and treatment. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The bibliography contains citations concerning biochemistry, therapy, and treatment of the effects of military chemical and biological warfare agents. References include surveys and studies of immunizing agents and drugs, the efficacy of these drugs, and the effect of the drugs on the patient. Also included are biochemical studies, assay techniques, and antidote development, some of which is supported by animal studies. Citations concerning detection and warning, defoliants, protection, biology and toxicology, and general studies are covered in separate bibliographies.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  4. Surface plasmon resonance detection of biological warfare agent Staphylococcal enterotoxin B using high affinity monoclonal antibody

    International Nuclear Information System (INIS)

    A novel sensitive method was developed for the detection as well as quantification of Staphylococcal enterotoxin B (SEB) using surface plasmon resonance (SPR). It is well known that the amount of SEB needed to cause the intoxication to human beings is very less and this concentration (0.02 μg/kg) is highly dangerous, hence, it is used as biological warfare agent. Thus, the need to develop a reliable and potential detection system against SEB is warranted. In the present work, SEB antibody was immobilized on carboxymethyldextran modified gold chip. The immobilization of SEB antibody and interaction of antigen with immobilized antibody were in-situ characterized by SPR and electrochemical impedance spectroscopy. A sample solution containing SEB antigen was injected in a working channel and the results revealed linearity in the concentration from 2.0 to 32.0 pM with a detection limit of 1.0 pM. By using kinetic evaluation software, KD (equilibrium constant) and Bmax (maximum binding capacity of analyte) values were calculated and found to be 13 pM and 424.23, respectively. Moreover, the thermodynamic parameter, change in Gibb's free energy was deduced and found to be -62.08 kJ/mol and this value shows the spontaneous interaction between SEB antigen and SEB antibody. In order to optimize the detection method, temperature and pH variation studies were also performed. Interference study was conducted to know the selectivity for the antigen-antibody interaction of SEB. The selectivity efficiency of SEB, SEC, SEA and SED were 100, 27.15, 20.01 and 12.05%, respectively towards SEB antibody.

  5. Multiple functional UV devices based on III-Nitride quantum wells for biological warfare agent detection

    Science.gov (United States)

    Wang, Qin; Savage, Susan; Persson, Sirpa; Noharet, Bertrand; Junique, Stéphane; Andersson, Jan Y.; Liuolia, Vytautas; Marcinkevicius, Saulius

    2009-02-01

    We have demonstrated surface normal detecting/filtering/emitting multiple functional ultraviolet (UV) optoelectronic devices based on InGaN/GaN, InGaN/AlGaN and AlxGa1-xN/AlyGa1-yN multiple quantum well (MQW) structures with operation wavelengths ranging from 270 nm to 450 nm. Utilizing MQW structure as device active layer offers a flexibility to tune its long cut-off wavelength in a wide UV range from solar-blind to visible by adjusting the well width, well composition and barrier height. Similarly, its short cut-off wavelength can be adjusted by using a GaN or AlGaN block layer on a sapphire substrate when the device is illuminated from its backside, which further provides an optical filtering effect. When a current injects into the device under forward bias the device acts as an UV light emitter, whereas the device performs as a typical photodetector under reverse biases. With applying an alternating external bias the device might be used as electroabsorption modulator due to quantum confined Stark effect. In present work fabricated devices have been characterized by transmission/absorption spectra, photoresponsivity, electroluminescence, and photoluminescence measurements under various forward and reverse biases. The piezoelectric effect, alloy broadening and Stokes shift between the emission and absorption spectra in different InGaN- and AlGaN-based QW structures have been investigated and compared. Possibilities of monolithic or hybrid integration using such multiple functional devices for biological warfare agents sensing application have also be discussed.

  6. Capillary zone electrophoresis analysis and detection of mid-spectrum biological warfare agents. Suffield memorandum No. 1463

    Energy Technology Data Exchange (ETDEWEB)

    Boulet, C.A.

    1995-12-31

    Mid-spectrum biological warfare agents such as proteins, peptides, and toxins are often difficult to analyze and often require individually developed assay methods for detection and identification. In this regard, capillary electrophoresis is an important, emerging technique for separation and quantitation of peptides and proteins, providing separation efficiencies up to two orders of magnitude greater than high performance liquid chromatography. The technique can also analyze a broad range of compounds, has a simple instrument design which can be automated, and has low sample volume requirements. In this study, a highly efficient and reproducible capillary zone electrophoresis method was developed to separate and identify a series of nine peptides of defense interest including bradykinin, leucine enkephalin, and oxytocin. The paper demonstrates three strategies which could be used in a fully automated field detection and identification system for unknown peptides.

  7. Biological warfare warriors, secrecy and pure science in the Cold War: how to understand dialogue and the classifications of science.

    Science.gov (United States)

    Bud, Robert

    2014-01-01

    This paper uses a case study from the Cold War to reflect on the meaning at the time of the term 'Pure Science'. In 1961, four senior scientists from Britain's biological warfare centre at Porton Down visited Moscow both attending an International Congress and visiting Russian microbiological and biochemical laboratories. The reports of the British scientists in talking about a limited range of topics encountered in the Soviet Union expressed qualities of openness, sociologists of the time associated with pure science. The paper reflects on the discourses of "Pure Science", secrecy and security in the Cold War. Using Bakhtin's approach, I suggest the cordial communication between scientists from opposing sides can be seen in terms of the performance, or speaking, of one language among several at their disposal. Pure science was the language they were allowed to share outside their institutions, and indeed political blocs.

  8. Chemical warfare agents

    Directory of Open Access Journals (Sweden)

    Vijayaraghavan R

    2010-01-01

    Full Text Available Among the Weapons of Mass Destruction, chemical warfare (CW is probably one of the most brutal created by mankind in comparison with biological and nuclear warfare. Chemical weapons are inexpensive and are relatively easy to produce, even by small terrorist groups, to create mass casualties with small quantities. The characteristics of various CW agents, general information relevant to current physical as well as medical protection methods, detection equipment available and decontamination techniques are discussed in this review article. A brief note on Chemical Weapons Convention is also provided.

  9. Governing Warfare

    DEFF Research Database (Denmark)

    Harste, Gorm

      It would seem as though warfare has gotten out of control, not only in Iraq and Afghanistan, but also in Central Africa. The paper outlines the strategic history of politically controlled warfare since the early Enlightenment. The argument is that control is implausible. The idea of control has...... the risks of lacking unity and displays the organisational trap to the fatal political myth of controlled warfare: Does it come from the military organisation system itself, from political ideologies of goal-rational governance, or from the chameleonic logic of wars?  ...... administration. While organisation systems continue to make some kind of political control possible, this is not the case in relation to wars. The organisation system is the in-between that should mediatise politics and war but is not functionally equivalent to just and unjust wars. The paper investigates...

  10. Development of Quantitative Real-Time PCR Assays for Detection and Quantification of Surrogate Biological Warfare Agents in Building Debris and Leachate▿

    OpenAIRE

    Pascal E. Saikaly; Barlaz, Morton A.; de los Reyes, Francis L.

    2007-01-01

    Evaluation of the fate and transport of biological warfare (BW) agents in landfills requires the development of specific and sensitive detection assays. The objective of the current study was to develop and validate SYBR green quantitative real-time PCR (Q-PCR) assays for the specific detection and quantification of surrogate BW agents in synthetic building debris (SBD) and leachate. Bacillus atrophaeus (vegetative cells and spores) and Serratia marcescens were used as surrogates for Bacillus...

  11. Transport behavior of surrogate biological warfare agents in a simulated landfill: Effect of leachate recirculation and water infiltration

    KAUST Repository

    Saikaly, Pascal

    2010-11-15

    An understanding of the transport behavior of biological warfare (BW) agents in landfills is required to evaluate the suitability of landfills for the disposal of building decontamination residue (BDR) following a bioterrorist attack on a building. Surrogate BW agents, Bacillus atrophaeus spores and Serratia marcescens, were spiked into simulated landfill reactors that were filled with synthetic building debris (SBD) and operated for 4 months with leachate recirculation or water infiltration. Quantitative polymerase chain reaction (Q-PCR) was used to monitor surrogate transport. In the leachate recirculation reactors, <10% of spiked surrogates were eluted in leachate over 4 months. In contrast, 45% and 31% of spiked S. marcescens and B. atrophaeus spores were eluted in leachate in the water infiltration reactors. At the termination of the experiment, the number of retained cells and spores in SBD was measured over the depth of the reactor. Less than 3% of the total spiked S. marcescens cells and no B. atrophaeus spores were detected in SBD. These results suggest that significant fractions of the spiked surrogates were strongly attached to SBD. © 2010 American Chemical Society.

  12. Interpretation of a New Found Japanese Biological Warfare File%对一份新发现日本细菌战档案的解读

    Institute of Scientific and Technical Information of China (English)

    宫文婧

    2016-01-01

    Unit 731 focused on the research of Biological Warfare theory in the plan of biological warfare , But be-cause? of lack of evidence chain , this research is relatively backward .Entry Hojo who was the core member of Unit 731 , his speech draft On Biological Warfareis the recently found materials and evidences , has great academic research value.Through the interpretation of the Biological Warfare , analyzing the biological warfare is the vital criterion to e-valuate the research level and research competence , which is also an effective supplement to the evidences for the Jap-anese biological warfare war of aggression against China .%七三一部队在细菌战谋划中注重对细菌战理论的研究,但囿于相关证据链的缺失,致使此项研究相对滞后。七三一部队核心成员北条圆了的演讲稿《关于细菌战》作为新资料、新证据,具有重大的学术研究价值,是对国内所藏相关资料的重要补充,有助于丰富学术界对于日本细菌战理论问题的认知。《关于细菌战》是北条圆了在长期实践基础上积累形成的细菌战理论,可以在一定程度上还原战时日本细菌战的研究情况。通过对北条圆了其人及《关于细菌战》的梳理和解读,进而剖析日本细菌战理论是评估二战时期日本细菌战研究水平和研究能力的重要尺度,也是对日本侵华细菌战证据链的有效补充。

  13. Capillary zone electrophoresis analysis and detection of mid-spectrum biological warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Boulet, C.A.; Townsley, C.

    1995-04-01

    DRE Suffield has initiated a research program to develop methods and equipment for field detection and laboratory identification of mid-spectrum agents, molecules of biological origin such as proteins, peptides and toxins. In this study, a highly efficient and reproducible capillary zone electrophoresis method was developed to separate and identify a series of nine peptides of defence interest: bradykinin, bradykinin fragment 1-5, substance P,ARG8-vasopressin, luteinizing hormone releasing hormone, bombesin, leucine enkephalin, methionine enkephalin, and oxytocin. Using a 50 micrometer x 47 cm capillary column, 22.5 kV separation voltage and a 100 mM pH 2.5 phosphate buffer, all nine peptide could separated in under 10 minutes. Three strategies, which could be used in a fully automated field detection and identification system, were demonstrated for the identification of unknown peptides: comparison of migration times, comparison of electrophoretic mobilities, and co-injection of multiple reference standards. These experiments demonstrate that a separation based analytical method such as capillary electrophoresis could form the basis of a generic detection system for mid-spectrum protein and peptide toxins.

  14. [The re-introduction of malaria in the Pontine Marshes and the Cassino district during the end of World War II. Biological warfare or global war tactics?].

    Science.gov (United States)

    Sabbatani, Sergio; Fiorino, Sirio; Manfredi, Roberto

    2013-12-01

    After the fall of the Fascist regime on September 8, 1943, Italy was split into two parts: (i) the Southern regions where the King Victor Emanuel III and the military general staff escaped was under the control of English-American allied armies, and (ii) the northern regions comprising Lazio, Tuscany, Umbria, and Marche still under the control of the Germans. The German Wehrmacht, after suffering several defeats on Southern lines, established a new strengthened line of defence called the Gustav line, located south of Rome and crossing in the western portion the recently-drained Pontine Marshes. In his book published in 2006, Frank Snowden hypothesised that occupying German armies in 1943 had initiated a programme of re-flooding the Pontine plain as a biological warfare strategy to re-introduce malaria infection in the territories south of Rome, Such a plan was intended (i) to slow down the advance of English-American forces, and (ii) to punish Italians who abandoned their former allies. Other authors, including Annibale Folchi, Erhard Geissler, and Jeanne Guillemin, have disputed this hypothesis based on an analysis of recently-uncovered archive documents. What is not disputed is that the flooding of the Pontine and Roman plains in 1943 contributed to a severe malaria epidemic in 1944, which was associated with exceptionally high morbidity and mortality rates in the afflicted populations. Herein, we critically evaluate the evidence and arguments of whether the Wehrmacht specifically aimed to spread malaria as a novel biological warfare strategy in Italy during the Second World War. In our opinion, evidence for specific orders to deliberately spread malaria by the German army is lacking, although the strategy itself may have been considered by Nazis during the waning years of the war.

  15. Nuclear radiation in warfare

    International Nuclear Information System (INIS)

    The subject is covered in chapters, entitled: introduction; digest of nuclear weaponry (characteristics of nuclear weapons; effects of nuclear weapons other than ionizing radiation (fire-ball, fall-out, thermal radiation, blast wave, electromagnetic pulse); the nuclear arms race; war scenarios; biological effects of radiations on man (radiation doses; natural sources of radiation; acute effects of radiation; long-term somatic effects; genetic effects; factors affecting the biological response to radiation; internal exposure; synergistic effects; protection against radiation effects); radiations from nuclear explosions (initial radiation; fall-out; effects of fall-out on animal and plant life; contamination of water and food supplies by fall-out); radiation casualties in a nuclear war; effectiveness of civil defence; other warlike uses of radiation (attacks on civilian nuclear power installations; radiological warfare; terrorist activities); conclusion. (orig./HP)

  16. Flying Electronic Warfare Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides NP-3D aircraft host platforms for Effectiveness of Navy Electronic Warfare Systems (ENEWS) Program antiship missile (ASM) seeker simulators used...

  17. Defining cyber warfare

    Directory of Open Access Journals (Sweden)

    Dragan D. Mladenović

    2012-04-01

    Full Text Available Cyber conflicts represent a new kind of warfare that is technologically developing very rapidly. Such development results in more frequent and more intensive cyber attacks undertaken by states against adversary targets, with a wide range of diverse operations, from information operations to physical destruction of targets. Nevertheless, cyber warfare is waged through the application of the same means, techniques and methods as those used in cyber criminal, terrorism and intelligence activities. Moreover, it has a very specific nature that enables states to covertly initiate attacks against their adversaries. The starting point in defining doctrines, procedures and standards in the area of cyber warfare is determining its true nature. In this paper, a contribution to this effort was made through the analysis of the existing state doctrines and international practice in the area of cyber warfare towards the determination of its nationally acceptable definition.

  18. The Physics of Warfare

    Science.gov (United States)

    Giordano, Gerardo

    2015-01-01

    Recently, I was tasked with the creation and execution of a new themed general education physics class called The Physics of Warfare. In the past, I had used the theme of a class, such as the physics of sports medicine, as a way to create homework and in-class activities, generate discussions, and provide an application to demonstrate that physics…

  19. Establishing Cyber Warfare Doctrine

    Directory of Open Access Journals (Sweden)

    Andrew M. Colarik

    2012-01-01

    Full Text Available Over the past several decades, advances in technology have transformed communications and the ability to acquire, disseminate, and utilize information in a range of environments. Modern societies and their respective militaries have taken advantage of a robust information space through network-centric systems. Because military and commercial operations have increasingly converged, communication and information infrastructures are now high-priority military objectives in times of war. This article examines the theoretical underpinning of current cyber warfare research, what we have learned so far about its application, and some of the emerging themes to be considered; it also postulates the development of a (national cyber warfare doctrine (CWD. An endeavor of this scale requires lots of considerations and preparation for its development if it is to be cooperatively embraced. This article considers why information technology systems and their supporting infrastructures should be considered legitimate military targets in conflicts, and offers several events that support this supposition. In addition, it identifies the various forms of doctrine that will become the basis for developing a CWD, discusses a CWD's possible components, and proposes a national collaborative and discussion framework for obtaining a nation's stakeholder buy-in for such an endeavor.

  20. The evolution of human warfare.

    Science.gov (United States)

    Pitman, George R

    2011-01-01

    Here we propose a new theory for the origins and evolution of human warfare as a complex social phenomenon involving several behavioral traits, including aggression, risk taking, male bonding, ingroup altruism, outgroup xenophobia, dominance and subordination, and territoriality, all of which are encoded in the human genome. Among the family of great apes only chimpanzees and humans engage in war; consequently, warfare emerged in their immediate common ancestor that lived in patrilocal groups who fought one another for females. The reasons for warfare changed when the common ancestor females began to immigrate into the groups of their choice, and again, during the agricultural revolution. PMID:22081837

  1. Iran and Cyberspace Warfare

    Directory of Open Access Journals (Sweden)

    Sami Kronenfeld

    2012-12-01

    Full Text Available Throughout the world decision makers and the general public have undoubtedly realized in recent years that cyberspace must be treated as a genuine realm of warfare. Since the the Stuxnet attack - one of the most destructive cyber attacks to date - Iran has been working hard to improve its cyberspace defenses on the one hand, while building up cyberspace intelligence gathering and offensive capabilities on the other. This article examines the current situation regarding various elements of Iran’s cyberspace development process. The first section analyzes the country’s cyberspace strategy, while the second section describes the organizational and operational response to the formulated strategy. This comprises three components: infrastructures for training and developing technological manpower for work in cyberspace; technological developments that have already been introduced; and the overall processes of cyberspace force construction. Finally, the article focuses on a number of cyberspace incidents attributed to Iran, attempts to gain some insight into the way Iran conducts its cyberspace activities, and examines implications for Israel and other Western nations.

  2. How Challenges of Warfare Influences the Laws of Warfare

    Directory of Open Access Journals (Sweden)

    Eyal Benvenisti

    2012-04-01

    Full Text Available The first challenge to laws of warfare comes from the realm of human rights, from the right to life. Today the situation is different. Laws of human rights have trickled into laws of warfare, even though they never mean to apply to them. In the process of formulating human rights laws there was never any intention that they be applied to a state of war. Their starting point was the power that a regime brings to bear on its citizens. This was not a case of horizontal warring - such as a duel or contest - but rather a hierarchy, a vertical relationship in which the one possessing public power controlled the citizen. This essay will deal with the challenges to the laws of warfare posed by fighting in urban zones, the consequent changes to these laws, and the problems these changes have aroused and responses to them.

  3. 美国在朝鲜战争中实施细菌战的证据%On Evidence of American Biological Warfare in the Korean War

    Institute of Scientific and Technical Information of China (English)

    张华

    2013-01-01

    The Investigation Report of American Biological War in North Korean and China by famous scien-tists from Sweden, France, England, Italia, Brazil, and Soviet Union is the core evidence of American biological war in the Korean War. Furthermore, there are at least six additional evidences:U.S.A. had the ability and desire to wage bi-ological war before and during the Korean War;it was reported by foreign newspapers that U.S.A. used Japanese bio-logical war troops to wage biological war;U.S.A. had biological war troops and bases in Japan;U.S.A. used the biolog-ical war technology and method of Japanese biological war troops;captive American pilots regretted their behaviors of waging biological war;the Chinese document of anti-biological war shows that the Chinese People’s Volunteers and the Chinese people in East Northern China were attacked by American biological war troops.%  60年前,由瑞典、法国、英国、意大利、巴西、苏联等6国知名科学家组团实地调查朝鲜战争中的细菌战后,向国际社会发表的《调查在朝鲜和中国的细菌战实事报告书及附件》,是美军在朝鲜战争中实施细菌战的核心证据。围绕这一核心证据,至少还有6个方面的旁系证据:美国在朝鲜战争前夕和期间具备实施细菌战的能力,并有着实施细菌战的强烈欲望;许多外媒报道,美国利用日本原细菌战人员,协助美军实施细菌战;朝鲜战争前夕和期间,美国在日本拥有细菌战部队和基地;朝鲜战争中实施的细菌战,明显袭用了“二战”期间日本细菌战技术和方法;被俘的美国飞行员对他们的细菌战行径表示忏悔,并写出供词;现存中国反细菌战档案表明,中国人民志愿军和东北人民确实受到美国细菌战攻击,中国由此展开了大规模的反细菌战运动。

  4. The doctor and nuclear warfare

    International Nuclear Information System (INIS)

    At the 34th World Medical Assembly in Lisbon in 1981 the World Medical Association adopted a motion proposed by the American Medical Association that national medical associations should develop programs to educate the civilian population on the medical consequences of nuclear war. This article discusses the attitude the medical professions should have, should nuclear warfare in some form confront them in the future. The conclusion is drawn that defence against nuclear warfare is only a part of civil defence against any disaster, including the natural disasters such as flood and fire and the man-made disasters of transport accidents, even of problems at nuclear plants designed to supply energy

  5. The Anatomy of Counterinsurgency Warfare

    DEFF Research Database (Denmark)

    Ringsmose, Jens; Pedersen, Kenneth

    Since the beginning of the new millennium, the West has been increasingly involved in a tiresome and rather particular type of conflict: insurgency warfare. The bloody and shocking terrorist attacks on New York and Washington in September 2001 marked the beginning of a new era, and the introducti...

  6. European Curricula, Xenophobia and Warfare.

    Science.gov (United States)

    Coulby, David

    1997-01-01

    Examines school and university curricula in Europe and the extent of their influence on xenophobia. Considers the pluralistic nature of the European population. Discusses the role of curriculum selection and language policy in state efforts to promote nationalism. Assesses the role of curricular systems in the actual encouragement of warfare,…

  7. Role of Smokes in Warfare .

    Directory of Open Access Journals (Sweden)

    P.K. Mishra

    1994-04-01

    Full Text Available The role smokes in warfare is reviewed with particular reference to the world wars, and various types os smokes are discussed. The smokes that can defeat modern opto-electronics including infrared (IR/millimetre wave (MMW guidance and thermal imager are described. Environment-friendly non-toxic smokes are dealt with briefly. The future of smokes in these circumstances is mentioned.

  8. Electronic warfare target location methods

    CERN Document Server

    Poisel, Richard

    2012-01-01

    Describing the mathematical development underlying current and classical methods of geolocating electronic systems that are emitting, this newly revised and greatly expanded edition of a classic Artech House book offers practical guidance in electronic warfare target location. The Second Edition features a wealth of additional material including new chapters on time delay estimation, direction finding techniques, and the MUSIC algorithm. This practical resource provides you with critical design information on geolocation algorithms, and establishes the fundamentals of existing algorithms as a

  9. MEANS AND METHODS OF CYBER WARFARE

    Directory of Open Access Journals (Sweden)

    Dan-Iulian VOITAȘEC

    2016-06-01

    Full Text Available According to the Declaration of Saint Petersburg of 1868 “the only legitimate object which States should endeavor to accomplish during war is to weaken the military forces of the enemy”. Thus, International Humanitarian Law prohibits or limits the use of certain means and methods of warfare. The rapid development of technology has led to the emergence of a new dimension of warfare. The cyber aspect of armed conflict has led to the development of new means and methods of warfare. The purpose of this paper is to study how the norms of international humanitarian law apply to the means and methods of cyber warfare.

  10. Cyber warfare building the scientific foundation

    CERN Document Server

    Jajodia, Sushil; Subrahmanian, VS; Swarup, Vipin; Wang, Cliff

    2015-01-01

    This book features a wide spectrum of the latest computer science research relating to cyber warfare, including military and policy dimensions. It is the first book to explore the scientific foundation of cyber warfare and features research from the areas of artificial intelligence, game theory, programming languages, graph theory and more. The high-level approach and emphasis on scientific rigor provides insights on ways to improve cyber warfare defense worldwide. Cyber Warfare: Building the Scientific Foundation targets researchers and practitioners working in cyber security, especially gove

  11. Information management and the biological warfare threat

    OpenAIRE

    Martinez, Antonio

    2002-01-01

    Approved for public release; distribution is unlimited This thesis explores the implications of information management of government-funded projects on national security objectives. A case study of the Human Genome Project is used to illustrate the risk of information transfer between government sources and private industry and the implications posed to the proliferation of Weapons of Mass Destruction. The issue of risk in information management is approached by developing three theoretica...

  12. Analytic tools for information warfare

    Energy Technology Data Exchange (ETDEWEB)

    Vandewart, R.L.; Craft, R.L.

    1996-05-01

    Information warfare and system surety (tradeoffs between system functionality, security, safety, reliability, cost, usability) have many mechanisms in common. Sandia`s experience has shown that an information system must be assessed from a {ital system} perspective in order to adequately identify and mitigate the risks present in the system. While some tools are available to help in this work, the process is largely manual. An integrated, extensible set of assessment tools would help the surety analyst. This paper describes one approach to surety assessment used at Sandia, identifies the difficulties in this process, and proposes a set of features desirable in an automated environment to support this process.

  13. Undersea Warfare Academic Group Home Page

    OpenAIRE

    1997-01-01

    Collected from the Internet Archive "Wayback machine". The Undersea Warfare Curriculum educates officers in the engineering fundamentals, physical principles and analytical concepts that govern operational employment of undersea warfare (USW) sensors and weapons systems. Program is interdisciplinary and integrates; mathematics, physics, acoustics, electrical engineering, oceanography, operations analysis, human factors, computer science and meteorology.

  14. Information warfare technologies in political discourse

    Directory of Open Access Journals (Sweden)

    Karpova Anna Yu.

    2016-01-01

    Full Text Available We attempt to examine the technology of «information warfare» in this paper. The dominant theme of the paper is that the outcome of the information warfare is important not only for the future of a state itself but for the future of the world balance of forces. The main task of geopolitical actors in information warfare is to introduce ideas corresponding to their interests into mass consciousness. All participants of political conflicts have common features in technologies of Information warfare. The information anomie is the indicator of the great geopolitical actors’ personified interests on the stage of «information warfare» - the process resulted in destroying the communicative line: report-information understanding and disrupting the social order in society. In this paper authors describe the following Information Warfare technologies: "Political volcano" technology; "SPIN" technology; "Widening media resource" technology; "specific gravity" technology; "Cold War 2.0" technology and Information cleaningup technology. It is assumed that in the future there will be new instructions on applying technologies of information warfare. To impart perspective to the paper we consider examples, opinions and trends.

  15. Grid architecture model of network centric warfare

    Institute of Scientific and Technical Information of China (English)

    Yan Tihua; Wang Baoshu

    2006-01-01

    NCW(network centric warfare) is an information warfare concentrating on network. A global network-centric warfare architecture with OGSA grid technology is put forward, which is a four levels system including the user level, the application level, the grid middleware layer and the resource level. In grid middleware layer, based on virtual hosting environment, a BEPL4WS grid service composition method is introduced. In addition, the NCW grid service model is built with the help of Eclipse-SDK-3.0.1 and Bpws4j.

  16. Chemical warfare, past and future. Study project

    Energy Technology Data Exchange (ETDEWEB)

    Tzihor, A.

    1992-05-15

    World War I was arena for the first use of chemical warfare. The enormous tactical success brought about by this first time use of chemical weapons caused the continued development of more sophisticated tactics and weapons in this category of unconventional warfare. This phenomenon has carried through to today. However, at present, because of technological developments, the global economic situation, and political factors, coupled with the inability of the western world to control the proliferation of chemical weapons, a situation weapon of mass destruction. Recent use by Iraq against Kurdish civilian indicates that chemical warfare is no longer limited to the battlefield. The western nations have a need to understand the risk. This paper conducts an analysis of past lessons and the factors which will affect the use of chemical warfare in the future. From this analysis, the paper reaches conclusions concerning the significant threat chemical weapons pose for the entire world in the not too distant future.

  17. Retention of junior Naval Special Warfare officers

    OpenAIRE

    Davids, Keith B.

    1998-01-01

    The Commander of the Naval Special Warfare Command (NSWC) has identified junior officer retention within the Naval Special Warfare community as a significant problem. In 1997, the community experienced the highest number of resignations on record, and this trend has continued in 1998. NSWC has taken several steps to identify the cause of recent retention trends, one of which was to provide support for this study. The purpose of this study was to identify the factors that lead to resignation o...

  18. Diagnosis of exposure to chemical warfare agents: An essential tool to counteract chemical terrorism

    NARCIS (Netherlands)

    Noort, D.; Schans, M.J. van der; Bikker, F.J.; Benschop, H.P.

    2009-01-01

    Methods to analyze chemical warfare agents (CW-agents) and their decomposition products in environmental samples were developed over the last decades. In contrast herewith, procedures for analysis in biological samples have only recently been developed. Retrospective detection of exposure to CW-agen

  19. Hybrid Warfare Studies and Russia’s Example in Crimea

    OpenAIRE

    Erol, Mehmet Seyfettin; Şafak OĞUZ

    2015-01-01

    Although Hybrid Warfare is an old concept, theoretical studies in the western countries mainly began in the post-Col War era, focusing on asymmetrical threats against conventional superiority of western countries such as USA or Israel. September 11th attacks and 2006 Israel-Lebanon war played important roles for the evolution of hybrid warfare theories. However, there has not any consensus among scholars on a exact or unique definition of hybrid warfare. Hybrid warfare became one of the main ...

  20. The Handicap Principle, Strategic Information Warfare and the Paradox of Asymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Zhanshan [University of Idaho; Sheldon, Frederick T [ORNL; Krings, Axel [ORNL

    2010-01-01

    The term asymmetric threat (or warfare) often refers to tactics utilized by countries, terrorist groups, or individuals to carry out attacks on a superior opponent while trying to avoid direct confrontation. Information warfare is sometimes also referred to as a type of asymmetric warfare perhaps due to its asymmetry in terms of cost and efficacy. Obviously, there are differences and commonalities between two types of asymmetric warfare. One major difference lies in the goal to avoid confrontation and one commonality is the asymmetry. Regardless, the unique properties surrounding asymmetric warfare warrant a strategic-level study. Despite enormous studies conducted in the last decade, a consensus on the strategy a nation state should take to deal with asymmetric threat seems still intriguing. In this article, we try to shed some light on the issue from the handicap principle in the context of information warfare. The Handicap principle was first proposed by Zahavi (1975) to explain the honesty or reliability of animal communication signals. He argued that in a signaling system such as one used in mate selection, a superior male is able to signal with a highly developed "handicap" to demonstrate its quality, and the handicap serves "as a kind of (quality) test imposed on the individual" (Zahavi 1975, Searcy and Nowicki 2005). The underlying thread that inspires us for the attempt to establish a connection between the two apparently unrelated areas is the observation that competition, communication and cooperation (3C), which are three fundamental processes in nature and against which natural selection optimize living things, may also make sense in human society. Furthermore, any communication networks, whether it is biological networks (such as animal communication networks) or computer networks (such as the Internet) must be reasonably reliable (honest in the case of animal signaling) to fulfill its missions for transmitting and receiving messages. The strategic

  1. Intelligence, Information Technology, and Information Warfare.

    Science.gov (United States)

    Davies, Philip H. J.

    2002-01-01

    Addresses the use of information technology for intelligence and information warfare in the context of national security and reviews the status of clandestine collection. Discusses hacking, human agent collection, signal interception, covert action, counterintelligence and security, and communications between intelligence producers and consumers…

  2. Agricultural Warfare and Bioterrorism using Invasive Species

    Science.gov (United States)

    The chapter on Agricultural Warfare and Bioterrorism using Invasive Species is part of the book titled Pest Management and Phytosanitary Trade Barriers authored by Neil Heather (Australia) and Guy Hallman. The chapter attempts to briefly put the topic into context with phytosanitation. It presents...

  3. Guiding Warfare to Reach Sustainable Peace

    DEFF Research Database (Denmark)

    Vestenskov, David; Drewes, Line

    The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition of develo...

  4. Computational models of intergroup competition and warfare.

    Energy Technology Data Exchange (ETDEWEB)

    Letendre, Kenneth (University of New Mexico); Abbott, Robert G.

    2011-11-01

    This document reports on the research of Kenneth Letendre, the recipient of a Sandia Graduate Research Fellowship at the University of New Mexico. Warfare is an extreme form of intergroup competition in which individuals make extreme sacrifices for the benefit of their nation or other group to which they belong. Among animals, limited, non-lethal competition is the norm. It is not fully understood what factors lead to warfare. We studied the global variation in the frequency of civil conflict among countries of the world, and its positive association with variation in the intensity of infectious disease. We demonstrated that the burden of human infectious disease importantly predicts the frequency of civil conflict and tested a causal model for this association based on the parasite-stress theory of sociality. We also investigated the organization of social foraging by colonies of harvester ants in the genus Pogonomyrmex, using both field studies and computer models.

  5. Handbook of toxicology of chemical warfare agents

    CERN Document Server

    2010-01-01

    This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book. This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves research...

  6. Animal plant warfare and secondary metabolite evolution

    OpenAIRE

    Wöll, Steffen; Kim, Sun Hee; Greten, Henry Johannes; Efferth, Thomas

    2013-01-01

    Abstract The long-lasting discussion, why plants produce secondary metabolites, which are pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood. In recent years, the concept of an animal plant warfare emerged, which focused on the co-evolution between plants and herbivores. As a reaction to herbivory, plants developed mechanical defenses such as thorns and hard shells, which paved the way for ad...

  7. Axial Vircator for Electronic Warfare Applications

    OpenAIRE

    L. Drazan; R. Vrana

    2009-01-01

    This paper deals with a high power microwave generator with virtual cathode – vircator in axial release for electronic warfare applications. The classification of directed energy weapons microwave (DEWM) is introduced together with basic block diagrams of a particular class of DEWM. In the paper, methods for designing vircator pulsed power supply, axial vircator structure, measurement methods and experimental results are presented. The vircator in electromagnetic ammunition is powered b...

  8. OFFICER AND COMMANDER IN ASYMMETRIC WARFARE OPERATIONS

    OpenAIRE

    Giuseppe CAFORIO

    2013-01-01

    Starting from the data of a field research conducted among soldiers with asymmetric warfare experiences from nine different countries, the author seeks to identify and shed light on the various problems that officers with command responsibilities had to face during their missions. A picture emerges of feelings and experiences relating to their first impression upon arriving in the theatre, relations with local armed forces, relations with the local population and local authorities, relations ...

  9. Hybrid Warfare Studies and Russia’s Example in Crimea

    OpenAIRE

    Erol, Mehmet Seyfettin; Şafak OĞUZ

    2015-01-01

    Although Hybrid Warfare is an old concept, theoretical studies in the western countries mainly began in the post-Col War era, focusing on asymmetrical threats against conventional superiority of western countries such as USA or Israel. September 11th attacks and 2006 Israel-Lebanon war played important roles for the evolution of hybrid warfare theories. However, there has not any consensus among scholars on a exact or unique definition of hybrid warfare. Hybrid warfare became one of the main ...

  10. OFFICER AND COMMANDER IN ASYMMETRIC WARFARE OPERATIONS

    Directory of Open Access Journals (Sweden)

    Giuseppe CAFORIO

    2013-01-01

    Full Text Available Starting from the data of a field research conducted among soldiers with asymmetric warfare experiences from nine different countries, the author seeks to identify and shed light on the various problems that officers with command responsibilities had to face during their missions. A picture emerges of feelings and experiences relating to their first impression upon arriving in the theatre, relations with local armed forces, relations with the local population and local authorities, relations with NGOs, relations with other armies, the impact of the rules of engagement (ROEs, training and education, and operational experiences. The paper ends with a discussion of the lessons learned.

  11. Microwave receivers with electronic warfare applications

    CERN Document Server

    Tsui, James

    2005-01-01

    This book by the author of Digital Techniques for Wideband Receivers willbe like no other one on your book shelf as the definitive word on electronicwarfare (EW) receiver design and performance. Whether you are an EWscientist involved in the test and evaluation of EW receivers or a designerof RWR's and other EW-related receivers, Microwave Receivers withElectronic Warfare Applications is a handy reference through which you canperfect your technical art. Lucidly written, this book is a treatise on EWreceivers that is relevant to you if you are just looking for a top-levelinsight into EW receive

  12. Axial Vircator for Electronic Warfare Applications

    Directory of Open Access Journals (Sweden)

    L. Drazan

    2009-12-01

    Full Text Available This paper deals with a high power microwave generator with virtual cathode – vircator in axial release for electronic warfare applications. The classification of directed energy weapons microwave (DEWM is introduced together with basic block diagrams of a particular class of DEWM. In the paper, methods for designing vircator pulsed power supply, axial vircator structure, measurement methods and experimental results are presented. The vircator in electromagnetic ammunition is powered by magneto-cumulative generator and in weapons for defense of objects (WDO, it is powered by Marx generator. The possible applications of a vircator in the DEWM area are discussed.

  13. Electronic warfare receivers and receiving systems

    CERN Document Server

    Poisel, Richard A

    2014-01-01

    Receivers systems are considered the core of electronic warfare (EW) intercept systems. Without them, the fundamental purpose of such systems is null and void. This book considers the major elements that make up receiver systems and the receivers that go in them.This resource provides system design engineers with techniques for design and development of EW receivers for modern modulations (spread spectrum) in addition to receivers for older, common modulation formats. Each major module in these receivers is considered in detail. Design information is included as well as performance tradeoffs o

  14. Chemical profiling of chemical warfare agents for forensic purposes

    NARCIS (Netherlands)

    Noort, D.; Reuver, L.P.J. de; Fidder, A.; Tromp, M.; Verschraagen, M.

    2010-01-01

    A program has been initiated towards the chemical profiling of chemical warfare agents, in order to support forensic investigations towards synthesis routes, production sites and suspect chemical suppliers. Within the first stage of the project various chemical warfare agents (VX, sulfur mustard, sa

  15. Hybrid Warfare Studies and Russia’s Example in Crimea

    Directory of Open Access Journals (Sweden)

    Mehmet Seyfettin EROL

    2015-12-01

    Full Text Available Although Hybrid Warfare is an old concept, theoretical studies in the western countries mainly began in the post-Col War era, focusing on asymmetrical threats against conventional superiority of western countries such as USA or Israel. September 11th attacks and 2006 Israel-Lebanon war played important roles for the evolution of hybrid warfare theories. However, there has not any consensus among scholars on a exact or unique definition of hybrid warfare. Hybrid warfare became one of the main security issues for the West and especially for NATO after the Russia-Ukraine crisis. Russian military strategies, called “hybrid warfare” by the western countries, resulted in the successful annexation of Crimea and, caused a serious security problem for the West resulting important structural and functional changes for the military system of NATO. Russian activities, which have been based on surprise, ambiguity and deniability, presented a unique example for hybrid warfare studies.

  16. Decontamination of Chemical Warfare Agents (Review Article

    Directory of Open Access Journals (Sweden)

    Beer Singh

    2010-07-01

    Full Text Available Chemical warfare agents (CWA pose inevitable threat, both to soldiers and civilians. Risk on contact with these deadly agents can be avoided by neutralisation of their toxic effects. A suitable media with essential physico-chemical properties is required for this purpose. Considerable efforts have been made to develop several decontamination media suitable for neutralisation of highly toxic CWAs. This paper reviews history and details of recent technological advancements in the development of versatile, broad spectrum decontamination formulations against CWAs, as also nanosized metal oxides as CWA decontaminants.Defence Science Journal, 2010, 60(4, pp.428-441, DOI:http://dx.doi.org/10.14429/dsj.60.487

  17. What Lies behind Chinese Cyber Warfare

    Directory of Open Access Journals (Sweden)

    Gabi Siboni

    2012-09-01

    Full Text Available Over the past several years China has been developing operational capabilities in the field of cyberspace warfare. A cyber attack may be defined as the unauthorized penetration of computer and communications systems belonging to individuals or organizations for the purpose of espionage and information theft, in order thereby to damage or disrupt the functioning of these systems or to damage other systems dependent on them, even to a point of causing actual physical damage. Despite denials by the Chinese government, researchers posit that China is behind a string of cyber attacks against the United States, Japan, France, Australia, and other Western nations. This essay argues that an analysis of the publicly available information about the more recent attacks makes it possible to establish that China does in fact stand behind these attacks and also makes it possible to identify the link between China’s cyberspace warfare strategy and its choice of targets. The analysis includes an examination of the companies attacked to identify possible motives for the attacks. The motives for these attacks are presumably to steal capabilities and conduct industrial espionage against nations and commercial competitors. Attacking companies and organizations in the financial and even political sectors allows access to valuable intelligence in these fields. By contrast, the intelligence value for immediate use in attacking companies providing critical infrastructures and communications services is usually relatively low. Rather, gaining access, if only to some providers of communications and internet services in the West and the United States, is liable to give attackers the ability to damage these services.

  18. Anthropology, Culture, and COIN in a Hybrid Warfare World

    OpenAIRE

    Simons, Anna

    2011-01-01

    in Paul Brister, William Natter, and Robert Tomes (eds.), Hybrid Warfare and Transnational Threats: Perspectives for an Era of Persistent Conflict. New York: Council for Emerging National Security Studies, 2011.

  19. Selfishness, warfare and economics; or integration, cooperation and biology

    Directory of Open Access Journals (Sweden)

    Emiliano Jesus Salvucci

    2012-05-01

    Full Text Available The acceptance of Darwin's theory of evolution by natural selection is not complete and it has been pointed out its limitation to explain the complex processes that constitute the transformation of species. The darwinian paradigm had its origin in the free market theories and concepts of Malthus and Spencer. Nature was explained on the basis of market theories moving away from an accurate explanation of natural phenomena. It is common that new discoveries bring about contradictions that are intended to be overcome by adjusting results to the dominant reductionist paradigm using all sorts of gradations and combinations that are admitted for each case. Modern findings represent a challenge to the interpretation of the observations with the Darwinian view of competition and struggle for life as theoretical basis. New holistic interpretations are emerging related with the Net of Life, in which the interconnection of ecosystems constitutes a dynamic and self-regulating biosphere: Viruses are recognized as a macroorganism with a huge collection of genes, most unknown, that constitute the major planet's gene pool with a fundamental role in evolution. The hologenome theory considers an organism and all of its associated symbiotic microbes as a result of symbiopoiesis. Microbes, helmints, that normally are understood as parasites, are cohabitants and they have cohabited with their host and drives the evolution and existence of the partners. Each organism is a result of integration of complex systems. The eukaryotic organism is the result of combination of bacterial, virus and eukaryotic DNA and the interaction of its own genome with the genome of its microbiota resulting in an intertwined metabolism (a superorganism along evolution. These new interpretations are remarkable points to be considered in order to construct a solid theory adjusted to the facts and with less speculations and tortuous semantic traps.

  20. Selfishness, warfare and economics; or integration, cooperation and biology

    OpenAIRE

    Emiliano Jesus Salvucci

    2012-01-01

    The acceptance of Darwin's theory of evolution by natural selection is not complete and it has been pointed out its limitation to explain the complex processes that constitute the transformation of species. The darwinian paradigm had its origin in the free market theories and concepts of Malthus and Spencer. Nature was explained on the basis of market theories moving away from an accurate explanation of natural phenomena. It is common that new discoveries bring about contradictions that are i...

  1. Selfishness, warfare, and economics; or integration, cooperation, and biology

    OpenAIRE

    Salvucci, Emiliano

    2012-01-01

    The acceptance of Darwin's theory of evolution by natural selection is not complete and it has been pointed out its limitation to explain the complex processes that constitute the transformation of species. It is necessary to discuss the explaining power of the dominant paradigm. It is common that new discoveries bring about contradictions that are intended to be overcome by adjusting results to the dominant reductionist paradigm using all sorts of gradations and combinations that are admitte...

  2. Active and Passive Precautions in Air and Missile Warfare

    OpenAIRE

    Sassoli, Marco; Quintin, Anne

    2014-01-01

    Based upon state practice, customary international law, Protocol Additional I to the Geneva Conventions and the Harvard Manual on Air and Missile Warfare (which they critically review), the authors discuss the different precautionary measures for the benefit of the civilian population an attacker and a defender must take, in the conduct of hostilities in general, and specifically in air and missile warfare, including in attacks against aircraft.

  3. From energy-rich phosphate compounds to warfare agents: A review on the chemistry of organic phosphate compounds

    OpenAIRE

    Luciano Albino Giusti; Vanderlei Gageiro Machado

    2008-01-01

    The chemistry of the phosphorus-oxygen bond is widely used in biological systems in many processes, such as energy transduction and the storage, transmission and expression of genetic information, which are essential to living beings in relation to a wide variety of functions. Compounds containing this bond have been designed for many purposes, ranging from agricultural defense systems, in order to increase food production, to nerve agents, for complaining use in warfare. In this review, feat...

  4. Conceptual Lanchester-type Decapitation Warfare Modelling

    Directory of Open Access Journals (Sweden)

    Jau-yeu Menq

    2007-07-01

    Full Text Available Decapitation operation has existed for a long time in military history; however, it was notuntil March 2003 'decapitation attack' became a well known term in the mass media. This paperis based on the connotation of decapitation based on historical study and refines the term intomilitary strategic concept of decapitation strategy. Ideas derived from detailed studies onLanchester-type combat models are used to describe the effectiveness of conventional regularforces under decapitation warfare, which includes asymmetric, nonlinear, stand-off and specialoperation forces (SOF operations. A conceptual model is presented to describe the effects ofthe decapitation strategy on the regular battlefield. With extensive coverage of operational factorssuch as robustness of forces, time difference between combats, undermining effects, breakpoints,attrition rates, total force level and force allocation, the model is suitable to analyse complexscenario with different types of military operations consisting of decapitation strategy. Anillustrative example is provided to demonstrate the application of the model. The conceptualmodel is built based on hypotheses, assumptions, and criteria. In the absence of historical data,no data analysis and parameter estimation are involved.

  5. Numerical simulation of RCS for carrier electronic warfare airplanes

    Directory of Open Access Journals (Sweden)

    Yue Kuizhi

    2015-04-01

    Full Text Available This paper studies the radar cross section (RCS of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carrier electronic warfare airplanes Model A and Model B with weapons were established. Based on the physical optics method and the equivalent electromagnetic flow method, by the use of the RCSAnsys software, the characteristics of carrier electronic warfare airplanes’ RCS under steady and dynamic flights were simulated under the UHF, X, and S radar bands. This paper researches the detection probability of aircraft by radars under the condition of electronic warfare, and completes the mathematical statistical analysis of the simulation results. The results show that: The Model A of carrier electronic warfare airplane is better than Model B on stealth performance and on discover probability by radar detection effectively.

  6. Nondestructive inspection of chemical warfare based on API-TOF

    International Nuclear Information System (INIS)

    Background: Real-time, fast, accurate, nondestructive inspection (NDI) and quantitative analysis for chemical warfare are very imperative for chemical defense, anti-terror and nation security. Purpose: Associated Particles Technique (APT)/Neutron Time of Flight (TOF) has been developed for non-invasive inspection of sealed containers with chemical warfare agents. Methods: A prototype equipment for chemical warfare is consisted of an APT neutron generator with a 3×3 matrix of semiconductor detectors of associated alpha-particles, the shielding protection of neutron and gamma-ray, arrayed NaI(Tl)-based detectors of gamma-rays, fully-digital data acquisition electronics, data analysis, decision-making software, support platform and remote control system. Inelastic scattering gamma-ray pulse height spectra of sarin, VX, mustard gas and adamsite induced by 14-MeV neutron are measured. The energies of these gamma rays are used to identify the inelastic scattering elements, and the intensities of the peaks at these energies are used to reveal their concentrations. Results: The characteristic peaks of inelastic scattering gamma-ray pulse height spectra show that the prototype equipment can fast and accurately inspect chemical warfare. Conclusion: The equipment can be used to detect not only chemical warfare agents but also other hazardous materials, such as chemical/toxic/drug materials, if their chemical composition is in any way different from that of the surrounding materials. (authors)

  7. Sweeping changes for mine warfare : controlling the mine threat

    OpenAIRE

    Cashman, T. Michael

    1994-01-01

    This thesis proposes that the U.S. Navy deter and, if necessary, combat potential minelayers by pursuing a pro-active' offensive mine warfare strategy. Central to this proposed strategy is the development, acquisition, and use of Remote Controlled (RECO) mines. It is argued that, given the historical problems the United States has had in the area of naval mine warfare, a strategy aimed at the aggressive deterrence of enemy mine laying be embraced so as to project forces ashore in future amphi...

  8. Integrated Assessment Systems for Chemical Warfare Material

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Snyder; D. A. Verrill; G. L. Thinnes; K. D. Watts; R. J. McMorland

    1999-05-27

    The US Army must respond to a variety of situations involving suspect discovered, recovered, stored, and buried chemical warfare materiel (CWM). In some cases, the identity of the fill materiel and the status of the fusing and firing train cannot be visually determined due to aging of the container, or because the item is contained in an over-pack. In these cases, non-intrusive assessments are required to provide information to allow safe handling, storage, and disposal of the materiel. This paper will provide an overview of the integrated mobile and facility-based CWM assessment system prototypes that have been, and are being developed, at the Idaho National Engineering and Environmental Laboratory (INEEL) for the US Army Non-Stockpile Chemical Materiel Project. In addition, this paper will discuss advanced sensors being developed to enhance the capability of the existing and future assessment systems. The Phase I Mobile Munitions Assessment System (MMAS) is currently being used by the Army's Technical Escort Unit (TEU) at Dugway Proving Ground, Utah. This system includes equipment for non-intrusively identifying the munitions fill materiel and for assessing the condition and stability of the fuzes, firing trains, and other potential safety hazards. The system provides a self-contained, integrated command post including an on-board computer system, communications equipment, video and photographic equipment, weather monitoring equipment, and miscellaneous safety-related equipment. The Phase II MMAS is currently being tested and qualified for use by the INEEL and the US Army. The Phase II system contains several new assessment systems that significantly enhance the ability to assess CWM. A facility-based munitions assessment system prototype is being developed for the assessment of CWM stored in igloos at Pine Bluff Arsenal, Arkansas. This system is currently in the design and fabrication stages. Numerous CWM advanced sensors are being developed and tested, and

  9. Environmental assessments of sea dumped chemical warfare agents

    DEFF Research Database (Denmark)

    Sanderson, Hans; Fauser, Patrik

    This is a report on the information gathered during work related to sea dumped chemical warfare agents. It mainly reviews the work conducted in relation to the installation of the two Nord Stream gas pipeline from 2008-2012. The focus was on the weight-of-evidence risk assessment of disturbed CWA...

  10. Public Discussion of Nuclear Warfare: A Time for Hope.

    Science.gov (United States)

    Cooper, Martha

    Anti-nuclear discourse, which peaked in 1981-82, signaled an emergence of public discourse on the nuclear warfare issue. During the development of the original atomic bomb, public discussion of the issue was severely restricted, but immediately after the bombing of Hiroshima and Nagasaki, discourse on the subject increased. During the Cold War…

  11. Anti-submarine warfare with continuously active sonar

    NARCIS (Netherlands)

    Vossen, R. van; Beerens, S.P.; Spek, E. van der

    2011-01-01

    Existing surveillance sonar systems for anti-submarine warfare (ASW) use a pulsed sonar deployed at a low duty cycle. Continuously active sonar (CAS) is of special interest since the technique could provide better detection performance than conventional pulsed sonar, and it will provide the operator

  12. Trends in underwater warfare : From an underwater acoustics perspective

    NARCIS (Netherlands)

    Ort, C.M.; Driessen, F.P.G.

    2002-01-01

    Technological developments concerning underwater systems for Anti Submarine Warfare (ASW) and Mine Counter Measures (MCM) are directed at optimally countering the underwater threat in the near future. Countering the existing underwater threat is already extremely difficult, but there are several tre

  13. Simulating cyber warfare and cyber defenses: information value considerations

    Science.gov (United States)

    Stytz, Martin R.; Banks, Sheila B.

    2011-06-01

    Simulating cyber warfare is critical to the preparation of decision-makers for the challenges posed by cyber attacks. Simulation is the only means we have to prepare decision-makers for the inevitable cyber attacks upon the information they will need for decision-making and to develop cyber warfare strategies and tactics. Currently, there is no theory regarding the strategies that should be used to achieve objectives in offensive or defensive cyber warfare, and cyber warfare occurs too rarely to use real-world experience to develop effective strategies. To simulate cyber warfare by affecting the information used for decision-making, we modify the information content of the rings that are compromised during in a decision-making context. The number of rings affected and value of the information that is altered (i.e., the closeness of the ring to the center) is determined by the expertise of the decision-maker and the learning outcome(s) for the simulation exercise. We determine which information rings are compromised using the probability that the simulated cyber defenses that protect each ring can be compromised. These probabilities are based upon prior cyber attack activity in the simulation exercise as well as similar real-world cyber attacks. To determine which information in a compromised "ring" to alter, the simulation environment maintains a record of the cyber attacks that have succeeded in the simulation environment as well as the decision-making context. These two pieces of information are used to compute an estimate of the likelihood that the cyber attack can alter, destroy, or falsify each piece of information in a compromised ring. The unpredictability of information alteration in our approach adds greater realism to the cyber event. This paper suggests a new technique that can be used for cyber warfare simulation, the ring approach for modeling context-dependent information value, and our means for considering information value when assigning cyber

  14. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  15. Rapid Ultrasensitive Chemical-Fingerprint Detection of Chemical and Biochemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    ASHBY, CAROL I.; SHEPODD, TIMOTHY J.; YELTON, WILLIAM G.; MURON, DAVID J.

    2002-12-01

    Vibrational spectra can serve as chemical fingerprints for positive identification of chemical and biological warfare molecules. The required speed and sensitivity might be achieved with surface-enhanced Raman spectroscopy (SERS) using nanotextured metal surfaces. Systematic and reproducible methods for preparing metallic surfaces that maximize sensitivity have not been previously developed. This work sought to develop methods for forming high-efficiency metallic nanostructures that can be integrated with either gas or liquid-phase chem-lab-on-a-chip separation columns to provide a highly sensitive, highly selective microanalytical system for detecting current and future chem/bio agents. In addition, improved protein microchromatographic systems have been made by the creation of acrylate-based porous polymer monoliths that can serve as protein preconcentrators to reduce the optical system sensitivity required to detect and identify a particular protein, such as a bacterial toxin.

  16. Stuxnet and Cyber-Warfare (1/2)

    CERN Document Server

    CERN. Geneva

    2016-01-01

    The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran's nuclear program. In the second part, the main features of cyber-warfare in conflict and pre-conflict activities will be discussed and compared to the conventional warfare domains, with also a general view at the international political debate on this topic. Check the http://pugwash.org web site, an organisation that seeks a world free of nuclear weapons and other weapons of mass destruction.   NB! All Academic Training lectures are recorded and are publicly available. There is no live webcast.

  17. Stuxnet and Cyber-Warfare (2/2)

    CERN Document Server

    CERN. Geneva

    2016-01-01

    The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran's nuclear program. In the second part, the main features of cyber-warfare in conflict and pre-conflict activities will be discussed and compared to the conventional warfare domains, with also a general view at the international political debate on this topic.   Check the http://pugwash.org web site, an organisation that seeks a world free of nuclear weapons and other weapons of mass destruction. The lecturer invites comments via email to Gian.Piero.Siroli@cern.ch NB! All Academic Training lectures are recorded and are publicly available. There is no live webcast.

  18. Annihilation Prediction for Lanchester-Type Models of Modern Warfare

    OpenAIRE

    Brown, G G; Taylor, J.

    1983-01-01

    Operations Research, 31, p.752. This paper introduces important new functions for analytic solution of Launch-ester-type equations of modern warfare for combat between two homogeneous forces modeled by power attrtition-rate coefficients with "no offset". Tabulations of these Lanchester-Clifford-Schlatii (or LCS) functions allow one to study this particular variable-coefficient model almost as easily and thoroughly as Lanchester's classic constant-coefficient one. LCS functions allow one ...

  19. Punishment sustains large-scale cooperation in prestate warfare

    OpenAIRE

    Mathew, Sarah; Boyd, Robert

    2011-01-01

    Understanding cooperation and punishment in small-scale societies is crucial for explaining the origins of human cooperation. We studied warfare among the Turkana, a politically uncentralized, egalitarian, nomadic pastoral society in East Africa. Based on a representative sample of 88 recent raids, we show that the Turkana sustain costly cooperation in combat at a remarkably large scale, at least in part, through punishment of free-riders. Raiding parties comprised several hundred warriors an...

  20. Factors affecting the retention decisions of female surface warfare officers

    OpenAIRE

    Clifton, Elizabeth A.

    2003-01-01

    This thesis delineates factors affecting the retention decisions of female Surface Warfare Officers. The data were obtained from in-depth interviews conducted with 12 female senior officers and 15 female junior officers. The transcripts from the interviews revealed 19 general themes. Based on the research, the data regarding the decisions that female officers make to either stay in the Navy or leave leads to four broad categories: economic factors, Navy taste factors., leadership factor...

  1. Simulation innovation in Naval Special Warfare by utilizing small working groups

    OpenAIRE

    Rainville, Thomas A.

    2001-01-01

    Naval Special Warfare has produced successful innovation by using small working groups. Naval Special Warfare deems an innovation successful if it results in a more efficient, less risky, more cost effective method to conduct special operations. The Quantum Leap program is an example of successful innovation in Naval Special Warfare produced by a small working group. How have these small groups been able to produce successful innovations? Michael McCaskey's Theory offers an explanation of how...

  2. Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents.

    Science.gov (United States)

    Madsen, J M

    2001-09-01

    Toxins are toxic chemical compounds synthesized in nature by living organisms. Classifiable by molecular weight, source, preferred targets in the body, and mechanism of action, they include the most potent poisons on the planet, although considerations of production, weaponization, delivery, environmental stability, and host factors place practical limits on their use as WMD. The two most important toxin threats on the battlefield or in bioterrorism are probably botulinum toxin (a series of seven serotypes, of which botulinum toxin A is the most toxic for humans) and SEB, an incapacitating toxin. Ricin and the trichothecene mycotoxins, including T-2 mycotoxin, are of lesser concern but are still potential threats. Botulinum toxin is a neurotoxin, ricin and trichothecene mycotoxins are membrane-damaging proteins, and SEB is a superantigen capable of massive nonspecific activation of the immune system. The clinical intoxications resulting from exposure to and absorption (usually by inhalation) of these agents reflect their underlying pathophysiology. Because of the hybrid nature of toxins, they have sometimes been considered CW agents and sometimes BW agents. The current trend seems to be to emphasize their similarities to living organisms and their differences from CW agents, but examination of all three groups relative to a number of factors reveals both similarities and differences between toxins and each of the other two categories of non-nuclear unconventional WMD. The perspective that groups toxins with BW agents is logical and very useful for research and development and for administrative and treaty applications, but for medical education and casualty assessment, there are real advantages in clinician use of assessment techniques that emphasize the physicochemical behavior of these nonliving, nonreplicating, intransmissible chemical poisons. PMID:11577702

  3. Electronic Warfare Simulation-based on Service Oriented Architecture

    Directory of Open Access Journals (Sweden)

    J. Nanda Kishore

    2012-07-01

    Full Text Available The realisation of service oriented architecture (SOA is embodied in the accomplishments of various simulation applicable functions in the form of service encapsulation and the interconnection and interoperation of services. In this paper, an electronic warfare (EW simulation is structured to SOA and achieved the effect of dynamic sharing and reusability. As a proof of concept, a radar electronic support (ES simulator, which intercepts and classifies radar signals is designed and explained in this paper.Defence Science Journal, 2012, 62(4, pp.219-222, DOI:http://dx.doi.org/10.14429/dsj.62.929

  4. Cybersecurity protecting critical infrastructures from cyber attack and cyber warfare

    CERN Document Server

    Johnson, Thomas A

    2015-01-01

    The World Economic Forum regards the threat of cyber attack as one of the top five global risks confronting nations of the world today. Cyber attacks are increasingly targeting the core functions of the economies in nations throughout the world. The threat to attack critical infrastructures, disrupt critical services, and induce a wide range of damage is becoming more difficult to defend against. Cybersecurity: Protecting Critical Infrastructures from Cyber Attack and Cyber Warfare examines the current cyber threat landscape and discusses the strategies being used by governments and corporatio

  5. THE EVOLUTION OF MODERN LAND WARFARE; THEORY AND PRACTICE

    Directory of Open Access Journals (Sweden)

    C.J. Jacobs

    2012-02-01

    Full Text Available Christopher Bellamy is 'n senior navorser verbonde aan die Sentrum vir Verdedigingstudies, Universiteit van Edinburgh. Sy akademiese opleiding sluit 'n MA-graad in Oorlogstudies aan die King's College in Londen in. Afgesien hiervan was hy ook 'n beroepsoldaat wat sy militêre skoling in die Koninklike Militêre Akademie te Sandhurst deurloop het. Hy het ook in die Britse Artillerie gedien. Bellamy is die skrywer van Red God of War: Soviet Artillery and Rocket Forces en The Future of Land Warfare.

  6. SCIENTIFIC AND PRACTICAL ASPECTS OF WATER BASIN CLEANING FROM CHEMICAL WARFARE AGENTS

    OpenAIRE

    T. M. Tiavlovskaya; V. F. Tamelo

    2011-01-01

    The paper contains an analysis of reasons that explain pollution of World Ocean waters by chemical warfare agents and ecological dangers which can arise due to their emission. Possible methods for liquidation of chemical warfare agents and water basin cleaning from them have been considered in the paper.

  7. Status of dental health in chemical warfare victims: The case of Isfahan, Iran

    Directory of Open Access Journals (Sweden)

    Ahmad Mottaghi

    2012-01-01

    Conclusion: Chemical warfare victims have relatively poor dental/oral health. Chemical injury might cause a dysfunction in saliva secretion, with decrease in saliva secretion increasing the risk for tooth decay and periodontal disorders. Further research is required to find out the exact underlying mechanisms and the factors associated with poor dental/oral health in chemical warfare victims.

  8. Is all fair in biological warfare? The controversy over genetically engineered biological weapons.

    Science.gov (United States)

    Appel, J M

    2009-07-01

    Advances in genetics may soon make possible the development of ethnic bioweapons that target specific ethnic or racial groups based upon genetic markers. While occasional published reports of such research generate public outrage, little has been written about the ethical distinction (if any) between the development of such weapons and ethnically neutral bioweapons. The purpose of this paper is to launch a debate on the subject of ethnic bioweapons before they become a scientific reality. PMID:19567692

  9. China's Use of Cyber Warfare: Espionage Meets Strategic Deterrence

    Directory of Open Access Journals (Sweden)

    Magnus Hjortdal

    2011-01-01

    Full Text Available This article presents three reasons for states to use cyber warfare and shows that cyberspace is—and will continue to be—a decisive element in China's strategy to ascend in the international system. The three reasons are: deterrence through infiltration of critical infrastructure; military technological espionage to gain military knowledge; and industrial espionage to gain economic advantage. China has a greater interest in using cyberspace offensively than other actors, such as the United States, since it has more to gain from spying on and deterring the United States than the other way around. The article also documents China's progress in cyber warfare and shows how it works as an extension of its traditional strategic thinking and the current debate within the country. Several examples of cyber attacks traceable to China are also presented. This includes cyber intrusions on a nuclear arms laboratory, attacks on defense ministries (including the Joint Strike Fighter and an airbase and the U.S. electric grid, as well as the current Google affair, which has proved to be a small part of a broader attack that also targeted the U.S. Government. There are, however, certain constraints that qualify the image of China as an aggressive actor in cyberspace. Some believe that China itself is the victim of just as many attacks from other states. Furthermore, certain actors in the United States and the West have an interest in overestimating China's capabilities in cyberspace in order to maintain their budgets.

  10. Punishment sustains large-scale cooperation in prestate warfare.

    Science.gov (United States)

    Mathew, Sarah; Boyd, Robert

    2011-07-12

    Understanding cooperation and punishment in small-scale societies is crucial for explaining the origins of human cooperation. We studied warfare among the Turkana, a politically uncentralized, egalitarian, nomadic pastoral society in East Africa. Based on a representative sample of 88 recent raids, we show that the Turkana sustain costly cooperation in combat at a remarkably large scale, at least in part, through punishment of free-riders. Raiding parties comprised several hundred warriors and participants are not kin or day-to-day interactants. Warriors incur substantial risk of death and produce collective benefits. Cowardice and desertions occur, and are punished by community-imposed sanctions, including collective corporal punishment and fines. Furthermore, Turkana norms governing warfare benefit the ethnolinguistic group, a population of a half-million people, at the expense of smaller social groupings. These results challenge current views that punishment is unimportant in small-scale societies and that human cooperation evolved in small groups of kin and familiar individuals. Instead, these results suggest that cooperation at the larger scale of ethnolinguistic units enforced by third-party sanctions could have a deep evolutionary history in the human species. PMID:21670285

  11. Toxin warfare agents:recognition molecules and drugs for control%生物毒素战剂:检测识别分子与防治药物

    Institute of Scientific and Technical Information of China (English)

    王景林

    2011-01-01

    There are various types of toxins in nature. However, these toxins. which are characterized by the ready availability, easy production and high toxicity, are likely biological warfare agents. Toxin warfare agents are different from traditional bacterial and viral agents or from chemical warfare agents in that they pose a great threat because of their diverse potency and the lack of efficacious drugs. Therefore, it is quite important to develop specific. sensitive recognition molecules for detection of toxins and drugs against intoxication caused by toxin agents. This review focuses on advances in recognition molecules of toxins and some drugs used as prevention and treatment hased on the characteristics of toxin warfare agents .%自然界中存在着种类繁多的毒素物质,但最有可能用作战剂的是那些获取方便、制备容易、毒性强、施放后可致人死亡或失能的毒素.毒素战剂既不同于传统的细菌、病毒战剂,也不同于化学毒剂,其最大的威胁来自它的高毒性及缺乏有效的治疗手段.因此,发展毒素战剂的检测识别分子与防治药物就显得尤为重要.本文讨论了生物毒素战剂相关概念、特征,重点综述了毒素战剂的检测识别分子与防治药物研究进展.

  12. Optics of Biological Particles

    CERN Document Server

    Hoekstra, Alfons; Videen, Gorden

    2007-01-01

    This book covers the optics of single biological particles, both theory and experiment, with emphasis on Elastic Light Scattering and Fluorescence. It deals with the optics of bacteria (bio-aerosols), marine particles (selected phytoplankton communities) and red and white blood cells. Moreover, there are dedicated chapters on a general theory for scattering by a cell, and modelling and simulation of scattering by inhomogeneous biological cells. Finally, one chapter is dedicated to astro-biological signatures, discussing the possibilities for detecting non-terrestrial biological material. The volume has up-to-date discussions on new experimental and numerical techniques, and many examples of applications of these techniques in real-life systems, as used to detect and characterize e.g. biological warfare agents or human blood cells.

  13. Editorial: Discovery from Lake Turkana and History of Human Warfare

    Directory of Open Access Journals (Sweden)

    Professor S. P. Singh, Ph.D.

    2016-02-01

    Full Text Available Very interesting finds have come to light of violently killed humans from Lake Turkana in the Kenyan Rift Valley around 10000 years ago. A stunning discovery of skeletons of 27 persons who are believed to have been killed at the same time and are supposed to have suffered violent wounds has been reported recently (Nature 529, 394–398, 21 January 2016. These finds belong to a period of late Pleistocene/early Holocene of the hunter-gatherer societies from Nataruk. Among the victims were men, women and children. The individuals were killed with projectiles and blunt weapons. These skeletons were found in the lagoon and were preserved very nicely. Such type of mass killing probably could never happen as a consequence of intra-group conflict. The evidence seems to be towards warfare and aggression in ancient societies. The experts ruled out the possibility of a cemetery and ceremonial burial. This discovery of 27 skeletons points to the fact that there may have been more causalities and many individuals might have escaped death at that time. According to one of the co-authors of this research Dr. R.A. Foley, the groups were elatively more densely packed populations than the hunter gatherers and had more chances of having inter-group conflicts because of sharing the resources which would have been plentiful near the lagoons and water bodies. Violence probably has been in the instinct of early humans and that the warfare among humans has a history of 10000 years or even earlier.

  14. Using cheminformatics to find simulants for chemical warfare agents

    International Nuclear Information System (INIS)

    Highlights: → Summary of chemical warfare agent (CWA) simulants in current use. → Application of method of molecular similarity to CWA and simulants. → Quantitative metric for CWA-simulant similarity. → Rank ordering of simulants in current use. → Potential of method to identify simulants for emerging agents. - Abstract: Direct experimentation with chemical warfare agents (CWA) to study important problems such as their permeation across protective barrier materials, decontamination of equipment and facilities, or the environmental transport and fate of CWAs is not feasible because of the obvious toxicity of the CWAs and associated restrictions on their laboratory use. The common practice is to use 'simulants,' namely, analogous chemicals that closely resemble the CWAs but are less toxic, with the expectation that the results attained for simulants can be correlated to how the CWAs would perform. Simulants have been traditionally chosen by experts, by means of intuition, using similarity in one or more physical properties (such as vapor pressure or aqueous solubility) or in the molecular structural features (such as functional groups) between the stimulant and the CWA. This work is designed to automate the simulant identification process backed by quantitative metrics, by means of chemical similarity search software routinely used in pharmaceutical drug discovery. The question addressed here is: By the metrics of such software, how similar are traditional simulants to CWAs? That is, what is the numerical 'distance' between each CWA and its customary simulants in the quantitative space of molecular descriptors? The answers show promise for finding close but less toxic simulants for the ever-increasing numbers of CWAs objectively and fast.

  15. The Third World War? In The Cyberspace. Cyber Warfare in the Middle East.

    Directory of Open Access Journals (Sweden)

    Martina

    2014-06-01

    Full Text Available This article aims to provide a brief and comprehensive introduction to the issue of cyber warfare and to display the recent development in this area. Geographically, it focuses on the Middle East region, since the vast majority of the most important recent cyber attacks appeared just in there or were connected to it. The first part of the article tries to define the key notion of cyber warfare, compares it to the standard warfare and presents different types of cyber weapons that are known today. The second part points out examples of the most striking recent cyber attacks and uses them as evidences to demonstrate today's importance and dissemination of cyber warfare. Finally, the article sums up pros and cons of the cyber weapons and, in view of these, predicts a significant increase in their use in any future war conflicts.

  16. Optimizing Armed Forces Capabilities for Hybrid Warfare – New Challenge for Slovak Armed Forces

    Directory of Open Access Journals (Sweden)

    Peter PINDJÁK

    2015-09-01

    Full Text Available The paper deals with the optimization of military capabilities of the Slovak Armed Forces for conducting operations in a hybrid conflict, which represents one of the possible scenarios of irregular warfare. Whereas in the regular warfare adversaries intend to eliminate the centers of gravity of each other, most often command and control structures, in irregular conflicts, the center of gravity shifts towards the will and cognitive perception of the target population. Hybrid warfare comprises a thoroughly planned combination of conventional military approaches and kinetic operations with subversive, irregular activities, including information and cyber operations. These efforts are often accompanied by intensified activities of intelligence services, special operation forces, and even mercenary and other paramilitary groups. The development of irregular warfare capabilities within the Slovak Armed Forces will require a progressive transformation process that may turn the armed forces into a modern and adaptable element of power, capable of deployment in national and international crisis management operations.

  17. Why mid-grade Surface Warfare officers are resigning from the Naval service.

    OpenAIRE

    Howell, James Robert

    1980-01-01

    This thesis addresses the reasons for mid-grade (0-2 to 0-4) Surface Warfare officer resignations. It makes recommendations that would possibly increase retention for the mid-grade Surface Warfare Officer Community. Statistical analyses were performed upon data from post-resignation questionnaires. A list of the ten most reported reasons for resigning was then compiled. A series of recommendations which might have a positive effect upon retention were then derived

  18. Platform-level Distributed Warfare Model-based on Multi-Agent System Framework

    Directory of Open Access Journals (Sweden)

    Xiong Li

    2012-05-01

    Full Text Available The multi-agent paradigm has become a useful tool in solving military problems. However, one of key challenges in multi-agent model for distributed warfare could be how to describe the microcosmic  tactical warfare platforms actions. In this paper, a platform-level distributed warfare model based on multi-agent system framework is designed to tackle this challenge. The basic ideas include:  Establishing multi-agent model by mapping from tactical warfare system’s members, i.e., warfare platforms, to respective agents; performing task decomposition and task allocation by using task-tree decomposition method and improved contract net protocol model technique; and implementing simulation by presenting battlefield terrain environment analysis algorithm based on grid approach. The  simulation demonstration results show that our model provides a feasible and effective approach to supporting the abstraction and representation of microcosmic tactical actions for complex warfare system.Defence Science Journal, 2012, 62(1, pp.180-186, DOI:http://dx.doi.org/10.14429/dsj.62.964

  19. Technological, military and social causes for the application of cyber warfare

    Directory of Open Access Journals (Sweden)

    Dragan D. Mladenović

    2012-01-01

    Full Text Available Cyber warfare is a specific new form of military conflicts the use of which is growing rapidly in the international community. However, its nature is specific and differs from all previously known forms of warfare. For the purpose of clear understanding of the nature of cyber warfare, this paper covers the basic groups of preconditions for its broad application and fast development from technological, military and social aspects. Understanding the true nature of cyber warfare is a necessary condition for building national capacities for its application that are military justified and harmonized with the international law. The paper explores the characteristic instances of cyber warfare, ranging from information propaganda to physical destruction, with the goal to determine guidelines for the possible development of cyber capacities at the national level. Based on the analysis of previous cyber warfare cases, a prediction of future development directions is made and the necessity to apply suitable methods and techniques for defense against them is analyzed.

  20. A Survey of Game Theoretic Approaches to Modelling Decision-Making in Information Warfare Scenarios

    Directory of Open Access Journals (Sweden)

    Kathryn Merrick

    2016-07-01

    Full Text Available Our increasing dependence on information technologies and autonomous systems has escalated international concern for information- and cyber-security in the face of politically, socially and religiously motivated cyber-attacks. Information warfare tactics that interfere with the flow of information can challenge the survival of individuals and groups. It is increasingly important that both humans and machines can make decisions that ensure the trustworthiness of information, communication and autonomous systems. Subsequently, an important research direction is concerned with modelling decision-making processes. One approach to this involves modelling decision-making scenarios as games using game theory. This paper presents a survey of information warfare literature, with the purpose of identifying games that model different types of information warfare operations. Our contribution is a systematic identification and classification of information warfare games, as a basis for modelling decision-making by humans and machines in such scenarios. We also present a taxonomy of games that map to information warfare and cyber crime problems as a precursor to future research on decision-making in such scenarios. We identify and discuss open research questions including the role of behavioural game theory in modelling human decision making and the role of machine decision-making in information warfare scenarios.

  1. Remote sensing of evaporation ducts for Naval warfare

    Science.gov (United States)

    Geernaert, G. L.

    1989-11-01

    Areas critical to naval operations are the prediction and application of atmospheric refractivity gradients. This report describes the use of the evaporation duct over the ocean and a plan for obtaining information about the evaporation duct by space-borne sensors. There has been little research on the theory and modeling of lower atmospheric refractivity, particularly evaporation ducts over a nonhomogeneous ocean over the past five decades. Much is known about surface layer similarity theory and propagation model techniques, but little attention has been placed on the spatial variabilities in the turbulent propagation medium (such as the atmospheric surface layer) in regions of strategic Navy interest. These regions include the coastal shelf, Gulf Stream, marginal ice zone, and those places where sharp sea surface temperature fronts exist. For tomorrow's Navy, using remote sensing techniques to infer evaporative and tropospheric ducts are a requirement. Although research efforts on ducts must couple the tropospheric and surface layer components, this report summarizes the state of the art for the evaporative duct and assess the potential of new and future results on improving next generation naval warfare capabilities.

  2. Unconventional Nuclear Warfare Defense (UNWD) containment and mitigation subtask.

    Energy Technology Data Exchange (ETDEWEB)

    Wente, William Baker

    2005-06-01

    The objective of this subtask of the Unconventional Nuclear Warfare Design project was to demonstrate mitigation technologies for radiological material dispersal and to assist planners with incorporation of the technologies into a concept of operations. The High Consequence Assessment and Technology department at Sandia National Laboratories (SNL) has studied aqueous foam's ability to mitigate the effects of an explosively disseminated radiological dispersal device (RDD). These benefits include particle capture of respirable radiological particles, attenuation of blast overpressure, and reduction of plume buoyancy. To better convey the aqueous foam attributes, SNL conducted a study using the Explosive Release Atmospheric Dispersion model, comparing the effects of a mitigated and unmitigated explosive RDD release. Results from this study compared health effects and land contamination between the two scenarios in terms of distances of effect, population exposure, and remediation costs. Incorporating aqueous foam technology, SNL created a conceptual design for a stationary containment area to be located at a facility entrance with equipment that could minimize the effects from the detonation of a vehicle transported RDD. The containment design was evaluated against several criteria, including mitigation ability (both respirable and large fragment particle capture as well as blast overpressure suppression), speed of implementation, cost, simplicity, and required space. A mock-up of the conceptual idea was constructed at SNL's 9920 explosive test site to demonstrate the containment design.

  3. Studies on residue-free decontaminants for chemical warfare agents.

    Science.gov (United States)

    Wagner, George W

    2015-03-17

    Residue-free decontaminants based on hydrogen peroxide, which decomposes to water and oxygen in the environment, are examined as decontaminants for chemical warfare agents (CWA). For the apparent special case of CWA on concrete, H2O2 alone, without any additives, effectively decontaminates S-2-(diisopropylamino)ethyl O-ethyl methylphosphonothioate (VX), pinacolyl methylphosphorofluoridate (GD), and bis(2-choroethyl) sulfide (HD) in a process thought to involve H2O2 activation by surface-bound carbonates/bicarbonates (known H2O2 activators for CWA decontamination). A plethora of products are formed during the H2O2 decontamination of HD on concrete, and these are characterized by comparison to synthesized authentic compounds. As a potential residue-free decontaminant for surfaces other than concrete (or those lacking adsorbed carbonate/bicarbonate) H2O2 activation for CWA decontamination is feasible using residue-free NH3 and CO2 as demonstrated by reaction studies for VX, GD, and HD in homogeneous solution. Although H2O2/NH3/CO2 ("HPAC") decontaminants are active for CWA decontamination in solution, they require testing on actual surfaces of interest to assess their true efficacy for surface decontamination. PMID:25710477

  4. Research on performance of ethernet interface in network centric warfare

    Institute of Scientific and Technical Information of China (English)

    梁永生; 张乃通

    2004-01-01

    The concept of network centric warfare (NCW) and its character, high requirement of real-time synchronization are introduced. The distributed equal-node network architecture in NCW is presented. Based on theoretical analysis on ethernet interface performance, this paper presents that forwarding latency between ethernet interface devices is a key influence factor of real-time synchronization in NCW. Ethernet fundamental is briefly introduced. The model between a switch under test (SUT) and a smartbits card is presented and used for two interconnecting switches in NCW. On condition that ignoring the latency of connecting fiber or twisted pairs and processing latency of the smartbits test system, this paper presents that clock frequency tolerance (CFT) between a SUT and a smartbits card is a leading influence factor of forwarding latency of an ethernet switch. The formulae to calculate internal forwarding latency and forwarding latency caused by its CFT are deduced. Theoretical calculation on forwarding latency of an ethernet switch based on the given CFT and test time is implemented. Experimental study on primary forwarding latency and secondary forwarding latency is implemented and forwarding latency between the SUT and the smartbits card is measured, thus testifying the accuracy of the above theoretical analysis that the CFT is a key influence factor of forwarding latency. The measures to satisfy the needs of forwarding latency in NCW are presented.

  5. Prevalence of Asthma in Children of Chemical Warfare Victims

    Science.gov (United States)

    Mirsadraee, Majid; Mozaffari, Abolfazl; Attaran, Davood

    2011-01-01

    Objective Exposure of DNA to sulfur mustard gas may increase the inheritance of asthma in chemical warfare victims' (CWV) offspring. The objective of this study was to determine the prevalence of asthma in children of CWV and compare it to asthmatic children in the general population. Methods Four hundred and nine children from 130 CWV fathers and 440 children from 145 asthmatic parents from two cities in Iran participated in this study. The prevalence of asthma was determined by standard questionnaire released for epidemiological survey of asthma in children and compared between two groups. Findings The prevalence of asthma in the CWV group was 15%; this was not significantly different from the control group (12.5%). The children of the CWV group reported a significantly greater incidence of wheezing (1.2±3.1 attacks) per year, but the control group reported more severe attacks leading to speech difficulties (3%) and coughing (7%). Regression analysis showed that with increasing family size in the control group, the number of subjects suffering from asthmatic symptoms decreases significantly (r=0.86, P=0.001). Conclusion Chemical agents may increase the prevalence of asthma in the offspring of CWV. PMID:23056804

  6. Virtual command center for distributed collaborative undersea warfare

    Science.gov (United States)

    Barton, Robert J., III; Encarnacao, L. M.; Shane, Richard T.; Drew, Ernest; Mulhearn, Jim F.

    2000-08-01

    The Naval Undersea Warfare Center, Division Newport (NUWCDIVNPT) and its partners have developed a prototype CTI (Command Technology Initiatives) Test Bed to demonstrate the utility of a facility where warfighters, government, academia and industry can evaluate the application of collaborate decision support and advanced computer graphics technologies to submarine command and control. The CTI Test bed is currently comprised of three components: Collaborative Visualization Environment (CVE) for Submarine Command and Control, which provides a coherent 3-D display of the perceived undersea battlespace. Individual windows can display multi-dimensional data/information to support a common picture of undersea battlespace management and tactical control; Submarine Fleet Mission Programming Library (SFMPL) which provides environmental data, such as transmission loss, to CVE; Command and Control Data Server which provides contact reports, areas of uncertainty, and ownship/contact motion to CVE Facilitated by a CORBA4 (Common Object Request Broker Architecture) compliant architecture, remotely connected collaborators interact via a computer network to generate and share information. Additionally, collaborators communicate orally via network telephony. Currently, the CTI Test bed is configured to provide volumetric displays of: undersea battlespace w/ bathymetry; Detection/Counter-detection regions for a given probability of detection; Contact(s) Volume of Uncertainty The CTI Test Bed provides a CORBA compliant framework, which can be readily expanded to evaluate candidate applications of collaborative command and tactical decision support and advanced computer graphics technologies.

  7. Back to the future: aerial warfare in Libya

    Directory of Open Access Journals (Sweden)

    João Paulo Nunes Vicente

    2013-05-01

    Full Text Available A century after the first air bomb mission, a new intervention in the same geographic space has made evident the changes in Airpower. The Aerial Warfare in Libya has radically changed the civil war, complying with a UN mission to protect Libyan population, imposing a no-fly zone and an arms embargo. Therefore, Operation Unified Protector became one of the most successful campaigns in the history of NATO. We aim to assess the operational efficiency of Airpower in the conflict in Libya, focusing on the challenges of a War essentially Aerial. Despite the military results and the fact that some political objectives were met, we can identify some concerning trends that, if not shifted, may negatively influence future NATO operations. We do not aim to draw general and universal conclusions on the strategic value of Airpower based on the analysis of a specific case. Above all, we focus on identifying some lessons which have influenced OUP operational efficiency. Thus, we must analyze some factors, such as the scope of objectives, the type of opposing action and aerial strategy used by the coalition and then focus on the challenges arising from the OUP.

  8. Guerilla Warfare & Law Enforcement: Combating the 21st Century Terrorist Cell within the U.S.

    Directory of Open Access Journals (Sweden)

    Major Richard Hughbank

    2009-01-01

    Full Text Available Both domestic and international terrorist organizations employ guerrilla warfare tactics, techniques, and procedures. Thus, the ability to identify and defeat the members of these organizations, cripple their infrastructures, and disrupt their financial resources lies in the understanding of modern guerrilla warfare as it develops in the twenty-first century within the United States.3 The forms of asymmetric warfare4 adopted by domestic and international terrorist groups alike is no longer intended to gain simple media exposure or governmental manipulation; they want to make an overpowering impact by causing massive loss of life and severe damage to infrastructure and are often motivated by religious imperatives and political goals. As terrorism analyst Stephen Flynn has observed, "Throughout the 20th century [Americans] were able to treat national security as essentially an out-of-body experience. When confronted by threats, [America] dealt with them on the turf of our allies or our adversaries. Aside from the occasional disaster and heinous crime, civilian life [in the United States] has been virtually terror-free." With the turn of the twenty-first century, terrorist operations have become more prevalent in the United States and are taking shape in the form of modern guerrilla warfare, thus creating new challenges for federal, state, and local law enforcement agencies. After reviewing the origin and nature of these challenges, this article will offer some suggestions for countering guerilla warfare in the United States.

  9. Guerra e desenvolvimento biológico: o caso da biotecnologia e da genômica na segunda metade do século XX Warfare and biological development: the case of biotechnology and genomics during the second half of the 20th Century

    Directory of Open Access Journals (Sweden)

    Maria Eneida de Almeida

    2006-09-01

    Full Text Available Desde a década de 1980, a Biotecnologia vem assumindo um papel cada vez mais importante dentro do planejamento estratégico das Grandes Potências, como elemento central para um novo tipo de arma ofensiva de destruição em massa e como paradigma para o planejamento de defesa e proteção de suas populações nacionais. Para defender esta tese, nosso estudo se orientou exatamente na história do deslocamento da Biologia para o centro do planejamento de defesa americano. Nosso objetivo foi investigar a existência de uma estreita relação entre o Desenvolvimento Biotecnológico, da ciência Genômica em particular, e a questão da guerra. Nossa hipótese é que a Biotecnologia se afirmou no campo da guerra, quando foram atingidos um ponto de condensação de fatos políticos e uma confluência de possibilidades biotécnicas que estimularam acentuadamente o interesse político-militar. A metodologia para a investigação desta conexão deu-se por dois caminhos: uma análise teórica, onde encontramos as origens e o mecanismo da Big Science desde a II Guerra Mundial, quando a Física assumiu o eixo central da ciência de ponta na era atômica, e desde a década de 1980, quando a Biologia passou a ocupar um lugar central; e uma análise historiográfica, acompanhando duas trajetórias convergentes que, para a nossa tese, formam o nervo central do Desenvolvimento Biotecnológico, da Guerra Biológica e do Projeto Genoma Humano.Since the 1980's, biotechnology has played an increasingly predominant role in the strategic planning of the super-powers, as the central element of a new type of mass destruction weapon as well as a model for defense planning and protection of their national populations. This study aims to demonstrate the path taken by Biology towards the core of American defense planning and also to investigate the close relationship between biotechnological development, in particular that of Genome Science and war. The specific hypothesis

  10. Systems for Detection and Identification of Biological Aerosols (Review Paper)

    OpenAIRE

    Eva Švabenska

    2012-01-01

    Easy and inexpensive manufacturing of biological weapons, their complicated detection, expensive protection, difficult treating of affected individuals, selective impact only for people, animals or plants, are all factors making an effective defense against biological warfare agents very difficult. The aim of this study is an introduction to the systems for the detection and identification of biological aerosols containing dangerous bioagents. The basic techniques used for detection and ident...

  11. THE CYBER DIMENSION OF MODERN HYBRID WARFARE AND ITS RELEVANCE FOR NATO

    Directory of Open Access Journals (Sweden)

    Sorin DUCARU

    2016-06-01

    Full Text Available The technological development and the instant communication possibilities advanced not only economic and social developments, but also evolving threats from those who exploit the vulnerabilities of communication and information systems. The cyber threat landscape points to a significant increase of the frequency, intensity, duration and sophistication of cyber-attacks. One of the new and concerning trends is the use of cyber capabilities in relation with military of hybrid operations – the so-called cyber dimension of hybrid warfare. NATO’s strategy on countering hybrid warfare is based on the triad: prepare-deter-defend, which also applies to cyber. Nations represent the first line of defence in countering hybrid strategies. International cooperation is also a key factor in this sense. It is in this context that NATO’s response to cyber-attacks in the context of hybrid warfare must be further refined.

  12. Treatability study report for remediation of chemical warfare agent contaminated soils using peroxysulfate ex-situ treatment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pugh, J.R.; Grinstead, J.H.; Farley, J.A.; Enlow, P.D.; Kelly, D.A.

    1996-07-01

    This laboratory scale study examines the feasibility of using peroxysulfate based oxidants to remediate soils contaminated with GB, Hi, and VX. The project was conducted with chemical warfare agent simulants. The study concludes that peroxysulfates, and particularly peroxydisulfate, can degrade chemical warfare agent simulants in soil and recommends continuing research.

  13. Skeletal evidence for Inca warfare from the Cuzco region of Peru.

    Science.gov (United States)

    Andrushko, Valerie A; Torres, Elva C

    2011-11-01

    This article addresses the bioarchaeological evidence for Inca warfare through an analysis of 454 adult skeletons from 11 sites in the Inca capital region of Cuzco, Peru. These 11 sites span almost 1000 years (AD 600-1532), which allows for a comparison of the evidence for warfare before the Inca came to power (Middle Horizon AD 600-1000), during the time of Inca ascendency in the Late Intermediate Period (AD 1000-1400), and after the Inca came to power and expanded throughout the Cuzco region and beyond (Inca Imperial Period, AD 1400-1532). The results indicate that 100 of 454 adults (22.0%) showed evidence of cranial trauma. Of these, 23 individuals had major cranial injuries suggestive of warfare, consisting of large, complete, and/or perimortem fractures. There was scant evidence for major injuries during the Middle Horizon (2.8%, 1/36) and Late Intermediate Period (2.5%, 5/199), suggesting that warfare was not prevalent in the Cuzco region before and during the Inca rise to power. Only in the Inca Imperial Period was there a significant rise in major injuries suggestive of warfare (7.8%, 17/219). Despite the significant increase in Inca times, the evidence for major cranial injuries was only sporadically distributed at Cuzco periphery sites and was entirely absent at Cuzco core sites. These findings suggest that while the Inca used warfare as a mechanism for expansion in the Cuzco region, it was only one part of a complex expansion strategy that included economic, political, and ideological means to gain and maintain control. PMID:21959843

  14. 毒物战的现实威胁%Threats of toxic warfare

    Institute of Scientific and Technical Information of China (English)

    刘芳; 赵建; 丁日高

    2013-01-01

    2002年,一份美国空军发起的关于毒物战争的研究报告引起了美国军方和平民灾难应急救援组织的关注。该报告通过对在战争中恶意使用有毒工业化学物质的历史事件的回顾,提出了毒物战( toxic warfare )的概念,并讨论了它对美国军事和国土安全的影响。该文综述了毒物战的历史及其对美国军事和国土安全的影响,分析了我国面临的毒物战威胁,并就应对毒物战威胁提出了若干启示。%In 2002, a research report about toxic warfare launched by the United States Air Force attracted the attentionof the U.S.military and civilian disaster emergency rescue organizations .By reviewing historical events related to the malicioususe of toxic industrial chemicals in the war , this report proposed the concept of "Toxic Warfare ", and discussed itsimpact on the United States military and homeland security .In this paper, the concept and history of toxic warfare and itsinfluence on American military and homeland security are reviewed , the threats of toxic warfare facing China and counter -measures against toxic warfare are analyzed.

  15. NONDESTRUCTIVE IDENTIFICATION OF CHEMICAL WARFARE AGENTS AND EXPLOSIVES BY NEUTRON GENERATOR-DRIVEN PGNAA

    Energy Technology Data Exchange (ETDEWEB)

    T. R. Twomey; A. J. Caffrey; D. L. Chichester

    2007-02-01

    Prompt gamma-ray neutron activation analysis (PGNAA) is now a proven method for the identification of chemical warfare agents and explosives in military projectiles and storage containers. Idaho National Laboratory is developing a next-generation PGNAA instrument based on the new Ortec Detective mechanically-cooled HPGe detector and a neutron generator. In this paper we review PGNAA analysis of suspect chemical warfare munitions, and we discuss the advantages and disadvantages of replacing the californium-252 radioisotopic neutron source with a compact accelerator neutron generator.

  16. Particle Swarm Social Adaptive Model for Multi-Agent Based Insurgency Warfare Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Xiaohui [ORNL; Potok, Thomas E [ORNL

    2009-12-01

    To better understand insurgent activities and asymmetric warfare, a social adaptive model for modeling multiple insurgent groups attacking multiple military and civilian targets is proposed and investigated. This report presents a pilot study using the particle swarm modeling, a widely used non-linear optimal tool to model the emergence of insurgency campaign. The objective of this research is to apply the particle swarm metaphor as a model of insurgent social adaptation for the dynamically changing environment and to provide insight and understanding of insurgency warfare. Our results show that unified leadership, strategic planning, and effective communication between insurgent groups are not the necessary requirements for insurgents to efficiently attain their objective.

  17. NONDESTRUCTIVE IDENTIFICATION OF CHEMICAL WARFARE AGENTS AND EXPLOSIVES BY NEUTRON GENERATOR-DRIVEN PGNAA

    International Nuclear Information System (INIS)

    Prompt gamma-ray neutron activation analysis (PGNAA) is now a proven method for the identification of chemical warfare agents and explosives in military projectiles and storage containers. Idaho National Laboratory is developing a next-generation PGNAA instrument based on the new Ortec Detective mechanically-cooled HPGe detector and a neutron generator. In this paper we review PGNAA analysis of suspect chemical warfare munitions, and we discuss the advantages and disadvantages of replacing the californium-252 radioisotopic neutron source with a compact accelerator neutron generator

  18. 15 CFR Supplement No. 1 to Part 742 - Nonproliferation of Chemical and Biological Weapons

    Science.gov (United States)

    2010-01-01

    ... Biological Weapons No. Supplement No. 1 to Part 742 Commerce and Foreign Trade Regulations Relating to...—Nonproliferation of Chemical and Biological Weapons Note: Exports and reexports of items in performance of...: (i) Equipment (for producing chemical weapon precursors and chemical warfare agents) described...

  19. THE TWENTIETH CENTURY DEVELOPMENT OF DIFFERENT TYPES OF BACTERIAL, BIOLOGICAL AND CHEMICAL WEAPONS AND THE PRESENT CAPABILITIES OF NATO AND THE WARSAW PACT IN THIS RESPECT

    OpenAIRE

    A.L.S. Hudson

    2012-01-01

    Over the last twenty years increased attention has been focused on the military uses of Bacterial, Biological and Chemical agents (BBC weapons). This phenomenon can be attributed to a number of reasons. Firstly, BBC weapons are comparatively cheap and simple to produce, they are easy to use as conventional weapons and their effects are short-lived. The mutual deterrence effect of nuclear weapons, furthermore, has necessitated the exploration of other fields of warfare of which - BBC warfare i...

  20. THE PECULIARITIES OF SOCIAL PERCEPTION IN THE CONTEXT OF INFORMATION-PSYCHOLOGICAL WARFARE

    Directory of Open Access Journals (Sweden)

    Nane Zeynalyan

    2016-09-01

    Full Text Available In the recent decades, war fields have moved into the information sphere. Today’s person has reason to “be informed”; as having information provides a sense of security. In the modern world, great effort is invested in expanding information sources, because it serves to articulate both international policies and the context of wars. The exchange of information in domestic and international platforms influences the quality of public debate and ideology, which affects social attitudes and decision-making processes. This article presents the role of information-psychological warfare as a factor in forming public opinion. It discusses the peculiarities of organizing an information-psychological warfare during military conflicts. The goal of our research is to explore how social groups might perceive peculiarities in the information-psychological warfare. The research involves methods of survey, content analysis, and free associations. The effectiveness of psychological warfare significantly depends on how people perceive information. Consequently, in the contemporary world, it is necessary to not only protect or fight on the battlefield, but also to use information weapons. This imposes requirements on psychological scientists to explore peculiarities around the perception of information to help find mechanisms that safeguard people’s lives by way of contributing to the formation of necessary attitudes and stereotypes.

  1. On modeling of the evaporation of chemical warfare agents on the ground

    NARCIS (Netherlands)

    Westin, S.N.; Winter, S.; Karlsson, E.; Hin, A.; Oeseburg, F.

    1998-01-01

    A model for evaporation of chemical warfare agents on the ground has been developed. The process of evaporation is described in three steps: (1) the immediate drop enlargement due to impact momentum is modeled using an empirical correlation from technical literature; (2) further enlargement caused b

  2. A statistical analysis of the effect of warfare on the human secondary sex ratio

    NARCIS (Netherlands)

    Graffelman, J.; Hoekstra, R.F.

    2000-01-01

    Many factors have been hypothesized to affect the human secondary sex ratio (the annual percentage of males among all live births), among them race, parental ages, and birth order. Some authors have even proposed warfare as a factor influencing live birth sex ratios. The hypothesis that during and s

  3. From Douhet to drones, air warfare, and the evolution of targeting

    NARCIS (Netherlands)

    F.P.B. Osinga; M.P. Roorda

    2016-01-01

    Through the prism of the experience of air warfare, this chapter identifies key factors that have shaped targeting. These include technological developments, organizational structures, and processes and inter-service competition for scarce resources. Moreover, targeting is informed by perspectives o

  4. An Empirical Examination of the Warfare Metaphor with Respect to Pre-Service Elementary Teachers

    Science.gov (United States)

    Cobern, William W.; Loving, Cathleen C.; Davis, Edward B.; Terpstra, Jeff

    2013-01-01

    Since its origination in the late nineteenth century, the warfare metaphor has been used to characterize the relationship between science and religion, especially orthodox Christianity. Though thoroughly discredited by historians of science, the ideological descendants of Thomas Huxley, who spoke of science in quasi-religious terms, have kept the…

  5. (Review of) Reno, William. 2011. Warfare in Independent Africa. Cambridge: Cambridge University Press

    DEFF Research Database (Denmark)

    Hagmann, Tobias

    2013-01-01

    Warfare in Independent Africa is Reno’s bold attempt to analyze the modern history of African insurgencies. The book tackles this task through the prism of five generations of rebel, which left their mark on the continent; anti-colonial rebels, majority rule rebels, reform rebels, warlord rebels ...

  6. Distinct human antibody response to the biological warfare agent Burkholderia mallei.

    Science.gov (United States)

    Varga, John J; Vigil, Adam; DeShazer, David; Waag, David M; Felgner, Philip; Goldberg, Joanna B

    2012-10-01

    The genetic similarity between Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis) had led to the general assumption that pathogenesis of each bacterium would be similar. In 2000, the first human case of glanders in North America since 1945 was reported in a microbiology laboratory worker. Leveraging the availability of pre-exposure sera for this individual and employing the same well-characterized protein array platform that has been previously used to study a large cohort of melioidosis patients in southeast Asia, we describe the antibody response in a human with glanders. Analysis of 156 peptides present on the array revealed antibodies against 17 peptides with a > 2-fold increase in this infection. Unexpectedly, when the glanders data were compared with a previous data set from B. pseudomallei infections, there were only two highly increased antibodies shared between these two infections. These findings have implications in the diagnosis and treatment of B. mallei and B. pseudomallei infections.

  7. The Future of Western Warfare: Coalitions and Capability Gaps; Strategic Insights, v. 10, Special issue (October 2011), 49-60. Topic: Global Trends and Future Warfare ; Part II: Technological and Doctrinal Innovation

    OpenAIRE

    Farrell, Theo

    2011-01-01

    This article appeared in Strategic Insights, V. 10, Special issue (October 2011), 49-60. Topic: Global Trends and Future Warfare ; Part II: Technological and Doctrinal Innovation Approved for public display, distribution unlimited This paper starts by making the case for coalition warfare focusing on a core of states within the North Atlantic Treaty Organization (NATO). Then goes on to discuss some of the capability shortfalls of European coalition partners. While technology is the most...

  8. From energy-rich phosphate compounds to warfare agents: A review on the chemistry of organic phosphate compounds

    Directory of Open Access Journals (Sweden)

    Luciano Albino Giusti

    2008-12-01

    Full Text Available The chemistry of the phosphorus-oxygen bond is widely used in biological systems in many processes, such as energy transduction and the storage, transmission and expression of genetic information, which are essential to living beings in relation to a wide variety of functions. Compounds containing this bond have been designed for many purposes, ranging from agricultural defense systems, in order to increase food production, to nerve agents, for complaining use in warfare. In this review, features related to the chemistry of organic phosphate compounds are discussed, with particular emphasis on the role of phosphate compounds in biochemical events and in nerve agents. To this aim, the energy-rich phosphate compounds are focused, particularly the mode of their use as energy currency in cells. Historical and recent studies carried out by research groups have tried to elucidate the mechanism of action of enzymes responsible for energy transduction through the use of biochemical studies, enzyme models, and artificial enzymes. Finally, recent studies on the detoxification of nerve agents based on phosphorous esters are presented, and on the utilization of chromogenic and fluorogenic chemosensors for the detection of these phosphate species.

  9. Extraordinary Adaptive Plasticity of Colorado Potato Beetle: “Ten-Striped Spearman” in the Era of Biotechnological Warfare

    Directory of Open Access Journals (Sweden)

    Aleksandar Cingel

    2016-09-01

    Full Text Available Expanding from remote areas of Mexico to a worldwide scale, the ten-striped insect, the Colorado potato beetle (CPB, Leptinotarsa decemlineata Say, has risen from being an innocuous beetle to a prominent global pest. A diverse life cycle, phenotypic plasticity, adaptation to adverse conditions, and capability to detoxify or tolerate toxins make this insect appear to be virtually “indestructible”. With increasing advances in molecular biology, tools of biotechnological warfare were deployed to combat CPB. In the last three decades, genetically modified potato has created a new challenge for the beetle. After reviewing hundreds of scientific papers dealing with CPB control, it became clear that even biotechnological means of control, if used alone, would not defeat the Colorado potato beetle. This control measure once again appears to be provoking the potato beetle to exhibit its remarkable adaptability. Nonetheless, the potential for adaptation to these techniques has increased our knowledge of this pest and thus opened possibilities for devising more sustainable CPB management programs.

  10. The Short-Term Effect of Chest Physiotherapy on Spirometric Indices in Chemical Warfare Victims Exposed to Mustard Gas

    OpenAIRE

    Abedi, A.; HR Koohestani; Z Roosta

    2008-01-01

    ABCTRACT Introduction & Objective: Chronic respiratory diseases are the most prevalent late sequels of sulfur mustard gas injury among Iranian chemical warfare victims. Chest physiotherapy is one of the useful methods in care, cure and infection prevention of these patients. The aim of this study was to determine the short-term effect of chest physiotherapy on spirometric indices in chemical warfare victims exposed to sulfur mustard gas. Materials & Methods: In this study, 27 of the chemical ...

  11. Modeling and Optimal Control of a Class of Warfare Hybrid Dynamic Systems Based on Lanchester Attrition Model

    OpenAIRE

    Xiangyong Chen; Ancai Zhang

    2014-01-01

    For the particularity of warfare hybrid dynamic process, a class of warfare hybrid dynamic systems is established based on Lanchester equation in a (n,1) battle, where a heterogeneous force of n different troop types faces a homogeneous force. This model can be characterized by the interaction of continuous-time models (governed by Lanchester equation), and discrete event systems (described by variable tactics). Furthermore, an expository discussion is presented on an optimal variable tact...

  12. Enhanced formulations for neutralization of chemical, biological and industrial toxants

    Science.gov (United States)

    Tucker, Mark D [Albuqueque, NM

    2008-06-24

    An enhanced formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The enhanced formulation according to the present invention is non-toxic and non-corrosive and can be delivered by a variety of means and in different phases. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a bleaching activator and water.

  13. Injuries sustained to the upper extremity due to modern warfare and the evolution of care.

    Science.gov (United States)

    Hofmeister, Eric P; Mazurek, Michael; Ingari, Jack

    2007-10-01

    The formation of the American Society for Surgery of the Hand was related to world conflicts and hostilities. Therefore, it is appropriate that upper-extremity surgeons understand injuries resulting from modern-day combat. Because of ongoing warfare, many countries have experienced a large increase in the number of wounded service members and civilians, particularly wounds of the extremities. As a result of increased rate of survival in battlefield trauma in part because of the use of modern body armor, there is increasing complexity of extremity injuries that require complex reconstructions. Decreased mortality and a consequent increase in the incidence of injured extremities underline the need for the development of new treatment options. The purpose of this presentation is to describe upper-extremity injury patterns in modern warfare, the levels of care available, and the treatment at each level of care based on the experience of the United States Military Medical Support System.

  14. The Military-Entertainment Complex: A New Facet of Information Warfare

    Directory of Open Access Journals (Sweden)

    Adam Muir

    2003-01-01

    Full Text Available The second Gulf War will become synonymous with the emergence of fully-fledged information warfare where the military-entertainment complex has so influenced strategic and logistic possibilities that it becomes apparent that the war was waged as entertainment. This is entertainment not as an amusement or diversion but utilising the techniques and tropes of the burgeoning entertainment industry as a means to achieve military objectives. This paper offers a short history of the military-entertainment complex as reality and simulation become fused in the practices of the US military machine. The paper then briefly explores three central aspects of this phenomenon evident in recent developments: the military function of computer games; the role of the Hollywood scenario and the blurring between news and reality TV. Finally the suggestion is made that subverting, co-opting and reconstructing the military-entertainment complex provides new possibilities for alternative strategies of information warfare.

  15. Bits or Shots in Combat? The Generalized Deitchman Model of Guerrilla Warfare

    OpenAIRE

    Kress, Moshe; MacKay, Niall J.

    2013-01-01

    Operations Research Letters, accepted. We generalize Deitchman's guerrilla warfare model to account for trade-off between intelligence ('bits') and firepower ('shots'). Intelligent targeting leads to aimed fire, absence of intelligence leads to unaimed fire, dependent on targets' density. We propose a new Lanchester-type model that mixes aimed with unaimed fire, the balance between these being determined by quality of information. We derive the model's conserved quantity, and use it ...

  16. A proficiency-based cost estimate of Surface Warfare Officer on-the-job training

    OpenAIRE

    Macaluso, Anthony D.

    2011-01-01

    Since 2003, the Surface Warfare Officer (SWO) community has changed initial training on two occasions. In 2003, they replaced schoolhouse training (SWOS) with an OJT intensive shipboard computer-based-training in response to criticism that SWOS was a wasteful use of six months. Yet, SWOs considered "SWOS-at-Sea" inadequate fleet preparation, prompting the reestablishment of one month of "SWO Intro." A 2010 Government Accountability Office report concluded the Navy must evaluate how changes to...

  17. Comment on “Computed Tomography Imaging Findings in Chemical Warfare Victims with Pulmonary Complications”

    OpenAIRE

    Shahrzad M.Lari

    2013-01-01

    Dr.Mirsadraei and colleagues performed an interesting study about the lung HRCT findings in chemical warfare patients who suffering from long-term pulmonary complications. They found that air trapping and mosaic attenuation were the most common lung HRCT findings. Also they divided patients in different clinical entities according to the lung HRCT findings (Bronchiolitis Oblitrans, pulmonary fibrosis, bronchiectasis, asthma, and COPD). At present, GOLD and GINA recommend the diagnosis of COPD...

  18. Hybrid Airship Multi-Role (HAMR) Anti-Submarine Warfare (ASW) mission capability

    OpenAIRE

    Agpaoa, Roy; Cawley, Matthew; Cossey, Chad; Galvan, Jose; Giang, Alan; Hanchinamani, Joseph; Ikeda, Jeffrey; Kenney, John; Magnusson, Lance; Martinez, Christopher; Newberry, Mike; Raymond, Eldridge; Rykala, John; Watts, Jason; Wood, Micheal

    2008-01-01

    The Hybrid Airship Multi-Role (HAMR) Anti-Submarine Warfare (ASW) Mission Module project applies established systems engineering principles and processes to the design of an ASW payload module that examines the capability of the HAMR to perform persistent ASW mission support. Critical system functions and objectives are identified and are assigned appropriate quantitative metrics. Additionally, three alternative architectures are generated and evaluated using the appropriate metrics based...

  19. Comparison of Selected Methods for Individual Decontamination of Chemical Warfare Agents

    OpenAIRE

    Tomas Capoun; Jana Krykorkova

    2014-01-01

    This study addresses the individual decontamination of chemical warfare agents (CWA) and other hazardous substances. The individual decontamination applies to contaminated body surfaces, protective clothing and objects immediately after contamination, performed individually or by mutual assistance using prescribed or improvised devices. The article evaluates the importance of individual decontamination, security level for Fire and Rescue Service Units of the Czech Republic (FRS CR) and demons...

  20. INFORMATION WEAPON CLASSIFICATION ACCORDING TO THE METHODS OF CONDUCTING INFORMATION WARFARE

    OpenAIRE

    Levchenko, Oleksandr V.

    2014-01-01

    Dynamic development of information technology has led to the development of informational weapon which is becoming the most dangerous tool of warfare between states. With the help of informational weapons can be conduct influence on informational resources of the hostile states and public opinion of the population. In accordance with it, informational weapon classified as information and technical weapon that affect the information resources, networks and systems of government and military ma...

  1. Toward a theory of hybrid warfare: the Russian conduct of war during peace

    OpenAIRE

    Dayspring, Stephen M.

    2015-01-01

    With the Russian annexation of Crimea and the undeclared conflict in eastern Ukraine, Western policy analysts have asked if Russia’s actions represent a new, more covert approach to warfare. Understanding Russia’s perspective on international relations is imperative to supporting potential targets of future Russian action, and specifically, to updating NATO’s defensive protocols that are predicated on response to clear military violations of sovereignty. This study uses an existing model for ...

  2. Theater level operations: modeling ground unit logistical requirements in the Joint Warfare Analysis Experimental Prototype

    OpenAIRE

    Wilk, Thomas J.

    1995-01-01

    This study proposes a methodology for modeling the logistics processes for ground units in the Joint Warfare Analysis Experimental Prototype (JWAEP) simulation. The model structure presented in this research allows for the representation of the consumption. movement, and distribution of supplies within the combat units modeled in JWAEP. Also presented is an architecture to model logistical units in JWAEP Methodologies are presented to model both the "push" and "pull" systems of supply. The su...

  3. Russia and hybrid warfare: identifying critical elements in successful applications of hybrid tactics

    OpenAIRE

    Neville, Seth B.

    2015-01-01

    Approved for public release; distribution is unlimited With the Russian annexation of Crimea in 2014, hybrid war became a buzzword within political and academic circles. This thesis examines hybrid warfare applications using contemporary and historical examples. The analysis seeks to determine why a country was or was not successful in its execution of hybrid war, and it assesses the geo-political context of cost, benefit, and risk for an aggressor state contributing to its decision to eng...

  4. [Principles of management in biological infections].

    Science.gov (United States)

    Płusa, Tadeusz

    2012-11-01

    The effectiveness of the management in respiratory infection is depending on the nature of the biological pathogen and the immune status of the patient. For this reason, providing assistance to victims the organ function support, similarly as defining the pathogen and targeted antibiotic therapy should be applied. Available diagnostic tests provide rapid ability to identify the pathogen and antibiotics are able to control infection. Lack of efficacy of treatment may indicate the diversity of the pathogen than previously known and raises suspicion of biological warfare pathogen.

  5. Operational advantages of using Cyber Electronic Warfare (CEW) in the battlefield

    Science.gov (United States)

    Yasar, Nurgul; Yasar, Fatih M.; Topcu, Yucel

    2012-06-01

    While cyberspace is emerging as a new battlefield, conventional Electronic Warfare (EW) methods and applications are likely to change. Cyber Electronic Warfare (CEW) concept which merges cyberspace capabilities with traditional EW methods, is a new and enhanced form of the electronic attack. In this study, cyberspace domain of the battlefield is emphazised and the feasibility of integrating Cyber Warfare (CW) concept into EW measures is researched. The SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis method is used to state the operational advantages of using CEW concept in the battlefield. The operational advantages of CEW are assessed by means of its effects on adversary air defense systems, communication networks and information systems. Outstanding technological and operational difficulties are pointed out as well. As a result, a comparison of CEW concept and conventional EW applications is presented. It is concluded that, utilization of CEW concept is feasible at the battlefield and it may yield important operational advantages. Even though the computers of developed military systems are less complex than normal computers, they are not subjected to cyber threats since they are closed systems. This concept intends to show that these closed systems are also open to the cyber threats. As a result of the SWOT analysis, CEW concept provides Air Forces to be used in cyber operations effectively. On the other hand, since its Collateral Damage Criteria (CDC) is low, the usage of cyber electronic attack systems seems to grow up.

  6. Chemical warfare and medical response during World War I.

    Science.gov (United States)

    Fitzgerald, Gerard J

    2008-04-01

    The first large-scale use of a traditional weapon of mass destruction (chemical, biological, or nuclear) involved the successful deployment of chemical weapons during World War I (1914-1918). Historians now refer to the Great War as the chemist's war because of the scientific and engineering mobilization efforts by the major belligerents. The development, production, and deployment of war gases such as chlorine, phosgene, and mustard created a new and complex public health threat that endangered not only soldiers and civilians on the battlefield but also chemical workers on the home front involved in the large-scale manufacturing processes. The story of chemical weapons research and development during that war provides useful insights for current public health practitioners faced with a possible chemical weapons attack against civilian or military populations.

  7. THE CONTRIBUTION MADE BY T.E. LAWRENCE TO THE THEORY OF REVOLUTIONARY WARFARE

    Directory of Open Access Journals (Sweden)

    G.K.B. Barron

    2012-02-01

    Full Text Available Lawrence was basically an academic thrown into the hurly-burly of leading an Arab revolt against Turkish domination. It could be said that the war in the Middle East was a sideshow of the First World War and Lawrence's part was a ' ... sideshow to the sideshow'l Why then has Lawrence been remembered when greater military men have been forgotten? The romanticism of his exploits are surely the reason, and yet the fact that he is the first modern theorist and possibly the "father" of modern revolutionary warfare, tends to be forgotten.

  8. Fear as a medium of communication in asymmetric forms of warfare

    DEFF Research Database (Denmark)

    Harste, Gorm

    2011-01-01

    of fear evolves in asymmetric warfare. Asymmetric war induces fear in both parties, but in a communicative form that leads to very different experiences of fear. Fear is observed and analysed with Niklas Luhmann’s theory of self-referential systems of communication and well as his theory of risk....... Following Luhmann and in continuation of Clausewitz’ conceptual tools, yet with other means, the article proposes to observe war as a system that can de-ontologize itself and thereby concern moving centres of gravity such as communication lines, motivation, public fear as well as perceptions of risk...

  9. New concepts and their applications in underwater acoustic warfare simulation system

    Institute of Scientific and Technical Information of China (English)

    DONG Yangze; YAO Lan

    2004-01-01

    An underwater acoustic warfare simulation system (UAWSS) with a structure of high level architecture (HLA) is studied based upon a previous research project. With the experience and lessons learned, some new concepts are adopted in the implementation of UAWSS according to the essence of simulation and the objective of the system, among which are simulation synthetic environment, signal processing at other simulation nodes, decomposition of underwater sound channel, channel varying law and rules on system and parts evaluation, etc. Applications of these new ideas show that they are effective.

  10. Women, rape and warfare: a gendered critique of Just War theory and the Immunity principle

    OpenAIRE

    Banwell, Stacy

    2011-01-01

    The just war tradition is based on two principles: jus ad bellum - just war-making, and jus in bello - just war-fighting. Jus in bello contains the non-combatant immunity principle. This “protects” civilians during war giving them “immunity” from the violence of war-fighting. Women are, for the most part, non-combatants. Still, their experiences during war are far from “protected”. Rape has been a feature of both traditional and civil warfare. The just war tradition is fundamentally ill-equ...

  11. International humanitarian law applied to cyber-warfare: Precautions, proportionality and the notion of ‘attack’ under the humanitarian law of armed conflict

    NARCIS (Netherlands)

    T.D. Gill

    2015-01-01

    This chapter examines the application of international humanitarian law to cyber warfare in the sense of rising to the level of an armed conflict. Building upon the work of the Tallinn Manual on the Application of International Law to Cyber Warfare, it places particular emphasis on the application o

  12. Academic Training Lectures | Stuxnet and Cyber-Warfare | 13-14 January 2016

    CERN Multimedia

    2015-01-01

    Please note that the next series of Academic Training Lectures will take place on 13 and 14 January 2016. The lectures will be given by Gian Piero Siroli (Università e INFN, Bologna (IT))   Stuxnet and Cyber-Warfare (1/2)​ on Wednesday, 13 January from 11 a.m. to 12 p.m. http://indico.cern.ch/event/438525/ Stuxnet and Cyber-Warfare (2/2) on Thursday, 14 January from 11 a.m. to 12 p.m. http://indico.cern.ch/event/438526/ at CERN, Council Chamber (503-1-001)  Description: The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran&...

  13. Investigating the Relationship Between Drone Warfare and Civilian Casualties in Gaza

    Directory of Open Access Journals (Sweden)

    Dr. Ann Rogers

    2014-12-01

    Full Text Available Unmanned aerial vehicles (UAVs, better known as drones, are increasingly touted as ‘humanitarian’ weapons that contribute positively to fighting just wars and saving innocent lives. At the same time, civilian casualties have become the most visible and criticized aspect of drone warfare. It is argued here that drones contribute to civilian casualties not in spite of, but because of, their unique attributes. They greatly extend war across time and space, pulling more potential threats and targets into play over long periods, and because they are low-risk and highly accurate, they are more likely to be used. The assumption that drones save lives obscures a new turn in strategic thinking that sees states such as Israel and the US rely on large numbers of small, highly discriminating attacks applied over time to achieve their objectives. This examination of Israel’s 2014 war in Gaza argues that civilian casualties are not an unexpected or unintended consequence of drone warfare, but an entirely predictable outcome.

  14. Ge{sup 4+} doped TiO{sub 2} for stoichiometric degradation of warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Stengl, Vaclav, E-mail: stengl@iic.cas.cz [Department of Solid State Chemistry, Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Grygar, Tomas Matys [Department of Solid State Chemistry, Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Oplustil, Frantisek; Nemec, Tomas [Military Technical Institute of Protection Brno, Veslarska 230, 628 00 Brno (Czech Republic)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer We prepared nanodisperse Ge{sup 4+} doped titania by a novel synthesis method. Black-Right-Pointing-Pointer Synthesis does not involve organic solvents, organometallics nor thermal processes. Black-Right-Pointing-Pointer The prepared materials are efficient in removal of chemical warfare agents. Black-Right-Pointing-Pointer Ge{sup 4+} doping improves rate of removal of soman and agent VX by TiO{sub 2}. - Abstract: Germanium doped TiO{sub 2} was prepared by homogeneous hydrolysis of aqueous solutions of GeCl{sub 4} and TiOSO{sub 4} with urea. The synthesized samples were characterized by X-ray diffraction, scanning electron microscopy, EDS analysis, specific surface area (BET) and porosity determination (BJH). Ge{sup 4+} doping increases surface area and content of amorphous phase in prepared samples. These oxides were used in an experimental evaluation of their reactivity with chemical warfare agent, sulphur mustard, soman and agent VX. Ge{sup 4+} doping worsens sulphur mustard degradation and improves soman and agent VX degradation. The best degree of removal (degradation), 100% of soman, 99% of agent VX and 95% of sulphur mustard, is achieved with sample with 2 wt.% of germanium.

  15. An Empirical Examination of the Warfare Metaphor with Respect to Pre-Service Elementary Teachers

    Science.gov (United States)

    Cobern, William W.; Loving, Cathleen C.; Davis, Edward B.; Terpstra, Jeff

    2013-08-01

    Since its origination in the late nineteenth century, the warfare metaphor has been used to characterize the relationship between science and religion, especially orthodox Christianity. Though thoroughly discredited by historians of science, the ideological descendants of Thomas Huxley, who spoke of science in quasi-religious terms, have kept the warfare metaphor alive. On the other hand, there are substantial numbers of Christians who at least appear to oppose science given their high-profile opposition to the general theory of evolution. The research reported in this paper asked, "Does anti-science sentiment increase with increasing orthodox Christian belief?" Two validated, published instruments were used: The Thinking about Science Survey Instrument and the Christian Fundamentalist Belief Scale. The subjects for the study were 545 preservice elementary teachers. The analysis did not show that anti-science sentiment increases with increasing Christian belief. Subjects with strong Christian beliefs were found to be just as supportive of science, if not more so, than subjects with no Christian beliefs. The study concludes with a caution against projecting attitudes toward science "on the whole" based on attitudes specifically toward evolution when working with preservice elementary teachers. Such a projection could well be counterproductive. The study has implications for other modern countries having highly religious populations such as Turkey.

  16. Next Generation Non-particulate Dry Nonwoven Pad for Chemical Warfare Agent Decontamination

    Energy Technology Data Exchange (ETDEWEB)

    Ramkumar, S S; Love, A; Sata, U R; Koester, C J; Smith, W J; Keating, G A; Hobbs, L; Cox, S B; Lagna, W M; Kendall, R J

    2008-05-01

    New, non-particulate decontamination materials promise to reduce both military and civilian casualties by enabling individuals to decontaminate themselves and their equipment within minutes of exposure to chemical warfare agents or other toxic materials. One of the most promising new materials has been developed using a needlepunching nonwoven process to construct a novel and non-particulate composite fabric of multiple layers, including an inner layer of activated carbon fabric, which is well-suited for the decontamination of both personnel and equipment. This paper describes the development of a composite nonwoven pad and compares efficacy test results for this pad with results from testing other decontamination systems. The efficacy of the dry nonwoven fabric pad was demonstrated specifically for decontamination of the chemical warfare blister agent bis(2-chloroethyl)sulfide (H or sulfur mustard). GC/MS results indicate that the composite fabric was capable of significantly reducing the vapor hazard from mustard liquid absorbed into the nonwoven dry fabric pad. The mustard adsorption efficiency of the nonwoven pad was significantly higher than particulate activated carbon (p=0.041) and was similar to the currently fielded US military M291 kit (p=0.952). The nonwoven pad has several advantages over other materials, especially its non-particulate, yet flexible, construction. This composite fabric was also shown to be chemically compatible with potential toxic and hazardous liquids, which span a range of hydrophilic and hydrophobic chemicals, including a concentrated acid, an organic solvent and a mild oxidant, bleach.

  17. Bioarchaeological investigation of ancient Maya violence and warfare in inland Northwest Yucatan, Mexico.

    Science.gov (United States)

    Serafin, Stanley; Lope, Carlos Peraza; Uc González, Eunice

    2014-05-01

    This study investigates evidence of changes and continuities in ancient Maya violence and warfare in inland northwest Yucatan, Mexico from the Middle Preclassic (600-300 BC) to the Postclassic (AD 1050-1542) through bioarchaeological analysis of cranial and projectile trauma. It is hypothesized that the frequency of violence increases before the Classic Maya collapse and remains high during the Postclassic period. It is also hypothesized that the flat, open terrain was conducive to warfare and resulted in higher trauma frequencies than in other parts of the Maya area. Results show that the frequency of cranial trauma decreases before the Classic collapse and increases in the Postclassic, partially matching the expected chronological trends. The frequency of cranial trauma does not differ significantly from other Maya regions but the pattern does: for all periods, males have more healed injuries than females and they are concentrated on the left side of the anterior of the skull. Some injuries appear to be from small points hafted in wooden clubs. In addition, projectile trauma is evident in a scapula with an embedded arrowhead tip, the first such case reported in a Maya skeleton. Overall, these results suggest greater reliance on open combat and less on raids in this region compared with other parts of the Maya area, possibly due to the flat, open terrain, though the identification of perimortem trauma in both women and men indicates surprise raids on settlements were also practiced.

  18. Zirconium doped nano-dispersed oxides of Fe, Al and Zn for destruction of warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Stengl, Vaclav, E-mail: stengl@uach.cz [Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Houskova, Vendula; Bakardjieva, Snejana; Murafa, Nataliya; Marikova, Monika [Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Oplustil, Frantisek; Nemec, Tomas [Military Technical Institute of Protection Brno, Veslarska 230, 628 00 Brno (Czech Republic)

    2010-11-15

    Zirconium doped nano dispersive oxides of Fe, Al and Zn were prepared by a homogeneous hydrolysis of the respective sulfate salts with urea in aqueous solutions. Synthesized metal oxide hydroxides were characterized using Brunauer-Emmett-Teller (BET) surface area and Barrett-Joiner-Halenda porosity (BJH), X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy (SEM) and energy-dispersive X-ray microanalysis (EDX). These oxides were taken for an experimental evaluation of their reactivity with sulfur mustard (HD or bis(2-chloroethyl)sulfide), soman (GD or (3,3'-Dimethylbutan-2-yl)-methylphosphonofluoridate) and VX agent (S-[2-(diisopropylamino)ethyl]-O-ethyl-methylphosphonothionate). The presence of Zr{sup 4+} dopant can increase both the surface area and the surface hydroxylation of the resulting doped oxides, decreases their crystallites' sizes thereby it may contribute in enabling the substrate adsorption at the oxide surface thus it can accelerate the rate of degradation of warfare agents. Addition of Zr{sup 4+} converts the product of the reaction of ferric sulphate with urea from ferrihydrite to goethite. We found out that doped oxo-hydroxides Zr-FeO(OH) - being prepared by a homogeneous hydrolysis of ferric and zirconium oxo-sulfates mixture in aqueous solutions - exhibit a comparatively higher degradation activity towards chemical warfare agents (CWAs). Degradation of soman or VX agent on Zr-doped FeO(OH) containing ca. 8.3 wt.% of zirconium proceeded to completion within 30 min.

  19. Implications for studying team cognition and team performance in network-centric warfare paradigms.

    Science.gov (United States)

    Krueger, Gerald P; Banderet, Louis E

    2007-05-01

    Network-centric warfare's (NCW) information-rich systems involving sophisticated sensors, tracking systems, smart weapons, and enhanced digital communications threaten to overload combatants with voluminous amounts of data. It is unclear whether warfighters will perceive such extensive data as actionable information to which they will respond accurately in a timely enough manner. Members of small teams in command and control centers, operating in crew-served vehicles, or simply "grunting it out" as ground-pounding infantrymen, may be disparately separated by space, but will communicate and be connected by electronic linkages, e.g., radio, text messages, situation displays, or global positioning data. However, team members will also have to remember shared mental models of tasks at hand, pay attention to and share common situation awareness in complex operational environments, perform team cognition and team coordination, and integrate both lower and higher cognitive processes with those of team behaviors. Such exceptional capabilities are required more now than ever before; such capabilities today are far from assured. After two workshops to establish performance metrics for assessing cognitive performance of military personnel in NCW, this preface introduces five manuscripts addressing team cognition and team performance from both a theoretical and a practical perspective. The authors of this preface question if NCW, and perhaps the politico-social ramifications of modern warfare, have already outstripped behavioral scientists' approach to researching team cognition and team performance-expertise that is so crucially needed for combatants on the rapidly changing 21st-century battlegrounds.

  20. Reevaluation of 1999 Health-Based Environmental Screening Levels (HBESLs) for Chemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Annetta Paule [ORNL; Dolislager, Fredrick G [ORNL

    2007-05-01

    This report evaluates whether new information and updated scientific models require that changes be made to previously published health-based environmental soil screening levels (HBESLs) and associated environmental fate/breakdown information for chemical warfare agents (USACHPPM 1999). Specifically, the present evaluation describes and compares changes that have been made since 1999 to U.S. Environmental Protection Agency (EPA) risk assessment models, EPA exposure assumptions, as well as to specific chemical warfare agent parameters (e.g., toxicity values). Comparison was made between screening value estimates recalculated with current assumptions and earlier health-based environmental screening levels presented in 1999. The chemical warfare agents evaluated include the G-series and VX nerve agents and the vesicants sulfur mustard (agent HD) and Lewisite (agent L). In addition, key degradation products of these agents were also evaluated. Study findings indicate that the combined effect of updates and/or changes to EPA risk models, EPA default exposure parameters, and certain chemical warfare agent toxicity criteria does not result in significant alteration to the USACHPPM (1999) health-based environmental screening level estimates for the G-series and VX nerve agents or the vesicant agents HD and L. Given that EPA's final position on separate Tier 1 screening levels for indoor and outdoor worker screening assessments has not yet been released as of May 2007, the study authors find that the 1999 screening level estimates (see Table ES.1) are still appropriate and protective for screening residential as well as nonresidential sites. As such, risk management decisions made on the basis of USACHPPM (1999) recommendations do not require reconsideration. While the 1999 HBESL values are appropriate for continued use as general screening criteria, the updated '2007' estimates (presented below) that follow the new EPA protocols currently under development

  1. Nuclear warfare

    CERN Multimedia

    Broda

    1981-01-01

    Le Prof.Broda a étudié à Vienne et Berlin et a travaillé pendant la dernière guerre mondiale en Grande Bretagne pour le conseil de la recherche médicale, notamment sur la chimie de la vision. Il est maintenant Prof. de la chimie, physique et radiochimie à l'Université de Vienne, où il concentre ses travaux sur les méchanisme de transport d'énergie à travers les cellules de membranes.

  2. Mobile Warfare

    Institute of Scientific and Technical Information of China (English)

    SEBASTIAN COHEN

    2008-01-01

    @@ In 1984, US computer manufacturer Apple spent almost USD 1.5 million on a lavish, Ridley Scott-directed commercial for its new Macintosh 128k personal computer. A year later, Microsoft released Microsoft Windows for IBM PC, signaling the start of the battle for domi-nation of the personal computer market which has waged ever since.

  3. Mechanical Warfare

    OpenAIRE

    Parman, Julian; Juuti, Jussi

    2015-01-01

    Tässä opinnäytetyössä luotiin tornipuolustuspeli Unityllä käyttäen 3D-malleja. Opinnäytetyön peli on demoversio. Peli on suunniteltu käyttäen suppeaa pelisuunnitelmaa. Pelin 3D-mallit on luotu käyttäen Blender 3D-mallinnusohjelmaa. Pelin grafiikat on tuotettu GIMP2-kuvankäsittelyohjelmalla. Pelin viholliset ja tornit on toteutettu 3D-malleina. Pelissä on tarkoituksena puolustaa omaa tukikohtaa vihollisaalloilta, jotka tulevat tietä pitkin. Lopputuloksena saatiin aikaan toimiva demoversio Mech...

  4. 76 FR 10522 - Naval Surface Warfare Center, Upper Machodoc Creek and the Potomac River, Dahlgren, VA; Danger Zone

    Science.gov (United States)

    2011-02-25

    ... Federal Register (75 FR 69033) with the docket number COE-2010-0038 and no comments were received... and the Potomac River, Dahlgren, VA; Danger Zone AGENCY: U.S. Army Corps of Engineers, DoD. ACTION... danger zone in the vicinity of Naval Surface Warfare Center, Dahlgren, in King George County,...

  5. Groundwater geochemical and selected volatile organic compound data, Operable Unit 1, Naval Undersea Warfare Center, Division Keyport, Washington, July 2015

    Science.gov (United States)

    Huffman, Raegan L.

    2016-05-18

    Previous investigations indicate that concentrations of chlorinated volatile organic compounds (CVOCs) are substantial in groundwater beneath the 9-acre former landfill at Operable Unit 1, Naval Undersea Warfare Center, Division Keyport, Washington. The U.S. Geological Survey has continued to monitor groundwater geochemistry to ensure that conditions remain favorable for contaminant biodegradation as specified in the Record of Decision for the site.

  6. Warfare has changed - so should have methods: Ammunition and weapon performance induced operational risk and safety issues

    NARCIS (Netherlands)

    Verhagen, T.L.A.; Voorde, M.J. van de

    2010-01-01

    Warfare has changed. Out-of-area operations have increased the awareness that we are unfamiliar with the performance of the current conventional medium and large calibre ammunitions in day-to-day practice. Current ammunition is primarily developed and procured to defeat the traditional ‘steel’ targe

  7. Warfare tourism experiences and national identity: The case of Airborne Museum ‘Hartenstein’ in Oosterbeek, the Netherlands

    NARCIS (Netherlands)

    Gieling, Johannes

    2016-01-01

    This paper examines through an analysis of Dutch warfare tourism whether there is a relationship between the subjective perceived salience of Dutch identity and heritage tourists' motives, emotions and overall satisfaction. Using a social identity theory framework, this study provides a view of moti

  8. Applications of swept-frequency acoustic interferometer for nonintrusive detection and identification of chemical warfare compounds

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, D.N.; Springer, K.; Han, W.; Lizon, D.; Kogan, S. [Los Alamos National Lab., NM (United States). Electronic Materials and Devices Group

    1997-12-01

    Swept-Frequency Acoustic Interferometry (SFAI) is a nonintrusive liquid characterization technique developed specifically for detecting and identifying chemical warfare (CW) compounds inside sealed munitions. The SFAI technique can rapidly (less than 20 seconds) and accurately determine sound speed and sound attenuation of a liquid inside a container over a wide frequency range (1 kHz-15 MHz). From the frequency-dependent sound attenuation measurement, liquid density is determined. These three physical properties are used to uniquely identify the CW compounds. In addition, various chemical relaxation processes in liquids and particle size distribution in emulsions can also be determined from the frequency-dependent attenuation measurement. The SFAI instrument is battery-operated and highly portable (< 6 lb.). The instrument has many potential application in industry ranging from sensitive detection (ppm level) of contamination to process control. The theory of the technique will be described and examples of several chemical industry applications will be presented.

  9. View the information-based battlefield environment system from network-centric warfare (NCW)

    Science.gov (United States)

    Zhang, Chengbin; You, Xiong

    2007-06-01

    Battlefield environment is a general designation for all kinds of objective things and conditions which surround battlefield and affect military actions. With the development of modern high technology, and information technology, traditional battlefield environment is developing in the both factors of space and constitutive, and takes on an integrated tendency. The U.S. military consider that the war of information age is NCW, and to successfully implement the theory of the NCW capabilities, the four domains of warfare-physical, information, cognitive, social, and their relationship must be understood. According to the theory of system, this paper puts forward the conception of Battlefield Environment System and its tetrahedron structure. The correlation of constitutive factors in Generalized Battlefield Environment System and the relationship between Generalized Battlefield Environment System and NCW are analyzed. Moreover, the spatial scope and constitutive factors of Specific Battlefield Environment System are also discussed.

  10. Approximation and Filtering Techniques for Navigation Data in Time-critical Electronic Warfare Systems

    Directory of Open Access Journals (Sweden)

    Vanitha D.

    2013-03-01

    Full Text Available This paper presents a holistic solution to the navigation requirements in a time critical electronic warfare systems like missile warning systems (MWS. In a passive MWS using IR sensors the efficiency of the system is determined by attributes such as low false alarm rate, minimal response time and ability to track different IR radiating objects by association and correlation of consecutive detections through time. Such a system is required to be supported by a navigation system capable of accurate estimation of the aircraft position, attitude angles and altitude. In this paper, estimation techniques used to accurately calculate aircraft navigation data at the time of capture of IR frames are discussed. The paper discusses about synchronization of INGPS, IR sensors & Processor on to same timeline. The paper also intends to evaluate the performance of wavelet transform filter in effective elimination of noise in navigation parameters like acceleration and attitude angle rates for a better estimation of position and attitude.

  11. Fate of chemical warfare agents and toxic indutrial chemicals in landfills

    DEFF Research Database (Denmark)

    Bartelt-Hunt, D.L.; Barlaz, M.A.; Knappe, D.R.U.;

    2006-01-01

    One component of preparedness for a chemical attack is planning for the disposal of contaminated debris. To assess the feasibility of contaminated debris disposal in municipal solid waste (MSW) landfills, the fate of selected chemical warfare agents (CWAs) and toxic industrial chemicals (TICs......], and two TICs [furan and carbon disulfide] were studied. The effects of both infiltration (climate) and contaminant biodegradability on fate predictions were assessed. Model results showed that hydrolysis and gas-phase advection were the principal fate pathways for CWAs and TICs, respectively. Apart from...... CX and the TICs, none of the investigated compounds was predicted to persist in a landfill for more than 5 years. Climate had little impact on CWA/TIC fate, and biodegradability was only important for compounds with long hydrolysis halflives. Monte Carlo simulations were performed to assess...

  12. Comparison of Selected Methods for Individual Decontamination of Chemical Warfare Agents

    Directory of Open Access Journals (Sweden)

    Tomas Capoun

    2014-06-01

    Full Text Available This study addresses the individual decontamination of chemical warfare agents (CWA and other hazardous substances. The individual decontamination applies to contaminated body surfaces, protective clothing and objects immediately after contamination, performed individually or by mutual assistance using prescribed or improvised devices. The article evaluates the importance of individual decontamination, security level for Fire and Rescue Service Units of the Czech Republic (FRS CR and demonstrates some of the devices. The decontamination efficiency of selected methods (sorbent, glove and sponge, two-chamber foam device and wiping with alcohol was evaluated for protective clothing and painted steel plate contaminated with O-ethyl-S-(diisopropylaminoethyl-methylthiophosphonate (VX, sulfur mustard, o-cresol and acrylonitrile. The methods were assessed from an economic point of view and with regard to specific user parameters, such as the decontamination of surfaces or materials with poor accessibility and vertical surfaces, the need for a water rinse as well as toxic waste and its disposal.

  13. Comment on “Computed Tomography Imaging Findings in Chemical Warfare Victims with Pulmonary Complications”

    Directory of Open Access Journals (Sweden)

    2013-08-01

    Full Text Available Dr.Mirsadraei and colleagues performed an interesting study about the lung HRCT findings in chemical warfare patients who suffering from long-term pulmonary complications. They found that air trapping and mosaic attenuation were the most common lung HRCT findings. Also they divided patients in different clinical entities according to the lung HRCT findings (Bronchiolitis Oblitrans, pulmonary fibrosis, bronchiectasis, asthma, and COPD. At present, GOLD and GINA recommend the diagnosis of COPD and asthma mainly on spirometry (1, 2. Although the HRCT may have valuable diagnostic points, but the diagnosis of COPD and asthma is according to the spirometry and relevant clinical symptoms. In this article, the authors relied only on clinical symptoms and corresponding lung HRCT findings that may have overlapping points in the diagnosis of asthma and COPD since normal lung HRCT with or without air trapping can be seen in COPD too (3. It has been proposed that saber-sheath trachea (tracheal index

  14. A review of current and future components for electronic warfare receivers

    Science.gov (United States)

    Collins, J. H.; Grant, P. M.

    1981-05-01

    This paper addresses the role of conventional and new components in passive electronic warfare (EW) receivers. The various areas of EW are defined before restricting the discussion predominantly to the radar intercept problem at microwave frequencies. The operational parameters of conventional components are then reviewed including the multiplexer; crystal video, instantaneous frequency measurement (IFM), and scanning superheterodyne receivers. The significance of modularity, digital control, and hybrid combinations of components is highlighted. A brief description follows of the operational Cutlass EW equipment. New components based on surface-acoustic waves (SAW) and acoustooptic (AO) Bragg cells are then presented and their particular importance in channelized receivers, IFM's, and microscan receivers noted. Finally, a number of conclusions are drawn covering likely trends in EW receivers and the need for continuing development of large-scale integrated (LSI) circuits for signal sorting and overall digital management.

  15. NETWORK-CENTRIC WARFARE AND SOME PARTICULAR ASPECTS OF LOGISTICS BASED ON NETWORKING

    Directory of Open Access Journals (Sweden)

    Petrişor JALBĂ

    2015-04-01

    Full Text Available Within the framework of the current revolution in military affairs, at the End of the Cold War a new concept was born: the concept of War Based on Computer Networking or NCW Network Centric-Warfare which was established as a central element of modern military operations. Determined by theprogress recorded in the field of communication systems of all types, technology of information (HI-Tech, IT, war based on computer networking brings a change in the war paradigm and its inherent components In this respect, logistics based on computer networking represents one of the ways in which the reality of the battlefield is preserved which enhances the joint perspective upon the military forces.

  16. Naval electronic warfare simulation for effectiveness assessment and softkill programmability facility

    Science.gov (United States)

    Lançon, F.

    2011-06-01

    The Anti-ship Missile (ASM) threat to be faced by ships will become more diverse and difficult. Intelligence, rules of engagement constraints, fast reaction-time for effective softkill solution require specific tools to design Electronic Warfare (EW) systems and to integrate it onboard ship. SAGEM Company provides decoy launcher system [1] and its associated Naval Electronic Warfare Simulation tool (NEWS) to permit softkill effectiveness analysis for anti-ship missile defence. NEWS tool generates virtual environment for missile-ship engagement and counter-measure simulator over a wide spectrum: RF, IR, EO. It integrates EW Command & Control (EWC2) process which is implemented in decoy launcher system and performs Monte-Carlo batch processing to evaluate softkill effectiveness in different engagement situations. NEWS is designed to allow immediate EWC2 process integration from simulation to real decoy launcher system. By design, it allows the final operator to be able to program, test and integrate its own EWC2 module and EW library onboard, so intelligence of each user is protected and evolution of threat can be taken into account through EW library update. The objectives of NEWS tool are also to define a methodology for trial definition and trial data reduction. Growth potential would permit to design new concept for EWC2 programmability and real time effectiveness estimation in EW system. This tool can also be used for operator training purpose. This paper presents the architecture design, the softkill programmability facility concept and the flexibility for onboard integration on ship. The concept of this operationally focused simulation, which is to use only one tool for design, development, trial validation and operational use, will be demonstrated.

  17. A review of research on common biological agents and their impact on environment

    International Nuclear Information System (INIS)

    Biological agents are unique class of microorganisms which can be used to produce the disease in large populations of humans, animals and plants. If used for hostile purposes, any disease-causing microorganism could be considered a weapon. The use of biological agents is not a new concept and history is replete with examples of biological weapon use. Before the twenty century, biological warfare took on three main forms by deliberate poisoning of food and water with infectious material, use of microorganisms or toxins in some form of weapon system, and use of biologically inoculated fabrics. Four kinds of biological warfare agents are bacteria, viruses, rickettsiae, fungi. These are distinguished by being living organisms, that reproduce within their host victims, who then become contagious with a deadly multiplier effect, bacteria, viruses, or fungi or toxin found in nature can be used to kill or injure people. Biological agents may be used for an isolated assassination, as well as to cause incapacitation or death to thousands. These biological agents represent a dangerous military threat because they are alive, and are therefore unpredictable and uncontrollable once released. The act of bioterrorism can range from a simple hoax to the actual use of biological weapons. Biological agents have the potential to make an environment more dangerous over time. If the environment is contaminated, a long-term threat to the population could be created. This paper discusses common biological agents, their mode of action in living organisms and possible impact on the environment. (author)

  18. THE TWENTIETH CENTURY DEVELOPMENT OF DIFFERENT TYPES OF BACTERIAL, BIOLOGICAL AND CHEMICAL WEAPONS AND THE PRESENT CAPABILITIES OF NATO AND THE WARSAW PACT IN THIS RESPECT

    Directory of Open Access Journals (Sweden)

    A.L.S. Hudson

    2012-02-01

    Full Text Available Over the last twenty years increased attention has been focused on the military uses of Bacterial, Biological and Chemical agents (BBC weapons. This phenomenon can be attributed to a number of reasons. Firstly, BBC weapons are comparatively cheap and simple to produce, they are easy to use as conventional weapons and their effects are short-lived. The mutual deterrence effect of nuclear weapons, furthermore, has necessitated the exploration of other fields of warfare of which - BBC warfare is a field. Another reason for this interest is the employment, on a limited scale, of such weapons in certain conflicts over this period.

  19. Research on the Interaction of Hydrogen-Bond Acidic Polymer Sensitive Sensor Materials with Chemical Warfare Agents Simulants by Inverse Gas Chromatography

    OpenAIRE

    Liu Yang; Qiang Han; Shuya Cao; Feng Huang; Molin Qin; Chenghai Guo; Mingyu Ding

    2015-01-01

    Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction. DMMP (a nerve gas simulant) and 2-CEES (a blister agent simulant) were used as probes. Chemical an...

  20. Research on Electronic Warfare Operational Simulation Experiment Design%电子对抗作战仿真实验设计研究

    Institute of Scientific and Technical Information of China (English)

    陶玉; 耿松涛; 王枭犇

    2013-01-01

      针对目前电子对抗作战仿真实验设计中存在的突出问题,对电子对抗作战仿真实验设计进行研究。介绍我军电子对抗作战仿真实验设计的发展现状,分析电子对抗作战仿真实验设计中存在的问题,提出结合实验目的规范电子对抗作战仿真实验设计的思路。该研究为实现电子对抗作战仿真实验设计的规范化、标准化做出了有益探索。%Aiming at the problems existed in designing electronic warfare operational simulation experiment, electronic warfare operational simulation experiment design is researched. It introduces the development situation of PLA’s electronic warfare operational simulation experiment firstly, analyses the problems in designing electronic warfare operational simulation experiment, and brings a design idea that combines it with experiment goals for electronic warfare operational simulation experiment. The research can offer reference for realize the normalization and standardization of electronic warfare campaign simulation experimental design.

  1. Modeling and Optimal Control of a Class of Warfare Hybrid Dynamic Systems Based on Lanchester (n,1 Attrition Model

    Directory of Open Access Journals (Sweden)

    Xiangyong Chen

    2014-01-01

    hybrid dynamic systems is established based on Lanchester equation in a (n,1 battle, where a heterogeneous force of n different troop types faces a homogeneous force. This model can be characterized by the interaction of continuous-time models (governed by Lanchester equation, and discrete event systems (described by variable tactics. Furthermore, an expository discussion is presented on an optimal variable tactics control problem for warfare hybrid dynamic system. The optimal control strategies are designed based on dynamic programming and differential game theory. As an example of the consequences of this optimal control problem, we take the (2, 1 case and solve the optimal strategies in a (2, 1 case. Simulation results show the feasibility of warfare hybrid system model and the effectiveness of the optimal control strategies designed.

  2. An analysis of the Civilian Employee Reward System in use at Naval Air Warfare Center, Patuxent River, Maryland

    OpenAIRE

    Montgomery, John F.

    1999-01-01

    Approved for public release; distribution is unlimited An incentive system should motivate employees to increase productivity and find innovative ways to control costs. In 1998, Naval Air Warfare Center, Aircraft Division, (NAWCAD) instituted a new reward system. At the request of the NAWCAD, this thesis sought to evaluate the effectiveness of the new reward system from the perspective of the employees affected by the system. The thesis examined current literature on motivation theory with...

  3. Development of a Polymerase Chain Reaction Assay for Detection of Burkholderia mallei, a Potent Biological Warfare Agent

    Directory of Open Access Journals (Sweden)

    Vijai Pal

    2016-09-01

    Full Text Available Burkholderia mallei is the etiological agent of glanders, primarily a disease of equines. B. mallei is closely related to B. pseudomallei, the causative agent of melioidosis. Therefore, detection of B. mallei and its differentiation from B. pseudomallei, has always been troublesome. In present investigation, a B. mallei specific DNA sequence was identified by performing BLASTn search using ~3000 ORFs of B. mallei NCTC 10229. A polymerase chain reaction (PCR assay with internal amplification control (IAC was developed for detection of B. mallei and its differentiation from B. pseudomallei. The PCR assay could amplify a specific 224-bp fragment from all the six B. mallei strains used in the study, whereas other closely related organisms were tested negative. The detection limit of the assay was found to be 10 pg of purified DNA of B. mallei. Incorporation of IAC in the assay makes the results reliable as false negative results which may arise due to presence of PCR inhibitors, can be avoided. For validation, the assay was tested on tap water, Bengal gram and grass artificially spiked with B. mallei. The developed assay can be used as a simple and rapid tool for detection of B. mallei.

  4. Multifunctional ultra-high vacuum apparatus for studies of the interactions of chemical warfare agents on complex surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Wilmsmeyer, Amanda R.; Morris, John R. [Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061 (United States); Gordon, Wesley O.; Mantooth, Brent A.; Lalain, Teri A. [Research and Technology Directorate, U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010 (United States); Davis, Erin Durke [OptiMetrics, Inc., Abingdon, Maryland 21009 (United States)

    2014-01-15

    A fundamental understanding of the surface chemistry of chemical warfare agents is needed to fully predict the interaction of these toxic molecules with militarily relevant materials, catalysts, and environmental surfaces. For example, rules for predicting the surface chemistry of agents can be applied to the creation of next generation decontaminants, reactive coatings, and protective materials for the warfighter. Here, we describe a multifunctional ultra-high vacuum instrument for conducting comprehensive studies of the adsorption, desorption, and surface chemistry of chemical warfare agents on model and militarily relevant surfaces. The system applies reflection-absorption infrared spectroscopy, x-ray photoelectron spectroscopy, and mass spectrometry to study adsorption and surface reactions of chemical warfare agents. Several novel components have been developed to address the unique safety and sample exposure challenges that accompany the research of these toxic, often very low vapor pressure, compounds. While results of vacuum-based surface science techniques may not necessarily translate directly to environmental processes, learning about the fundamental chemistry will begin to inform scientists about the critical aspects that impact real-world applications.

  5. Applicability of federal and state hazardous waste regulatory programs to waste chemical weapons and chemical warfare agents.; TOPICAL

    International Nuclear Information System (INIS)

    This report reviews federal and state hazardous waste regulatory programs that govern the management of chemical weapons or chemical warfare agents. It addresses state programs in the eight states with chemical weapon storage facilities managed by the U.S. Army: Alabama, Arkansas, Colorado, Indiana, Kentucky, Maryland, Oregon, and Utah. It also includes discussions on 32 additional states or jurisdictions with known or suspected chemical weapons or chemical warfare agent presence (e.g., disposal sites containing chemical agent identification sets): Alaska, Arizona, California, Florida, Georgia, Hawaii, Idaho, Illinois, Iowa, Kansas, Louisiana, Massachusetts, Michigan, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, New York, North Carolina, Ohio, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, the U.S. Virgin Islands, Virginia, Washington, Washington, D.C., and Wyoming. Resource Conservation and Recovery Act (RCRA) hazardous waste programs are reviewed to determine whether chemical weapons or chemical warfare agents are listed hazardous wastes or otherwise defined or identified as hazardous wastes. Because the U.S. Environmental Protection Agency (EPA) military munitions rule specifically addresses the management of chemical munitions, this report also indicates whether a state has adopted the rule and whether the resulting state regulations have been authorized by EPA. Many states have adopted parts or all of the EPA munitions rule but have not yet received authorization from EPA to implement the rule. In these cases, the states may enforce the adopted munitions rule provisions under state law, but these provisions are not federally enforceable

  6. Plastic antibody for the recognition of chemical warfare agent sulphur mustard.

    Science.gov (United States)

    Boopathi, M; Suryanarayana, M V S; Nigam, Anil Kumar; Pandey, Pratibha; Ganesan, K; Singh, Beer; Sekhar, K

    2006-06-15

    Molecularly imprinted polymers (MIPs) known as plastic antibodies (PAs) represent a new class of materials possessing high selectivity and affinity for the target molecule. Since their discovery, PAs have attracted considerable interest from bio- and chemical laboratories to pharmaceutical institutes. PAs are becoming an important class of synthetic materials mimicking molecular recognition by natural receptors. In addition, they have been utilized as catalysts, sorbents for solid-phase extraction, stationary phase for liquid chromatography and mimics of enzymes. In this paper, first time we report the preparation and characterization of a PA for the recognition of blistering chemical warfare agent sulphur mustard (SM). The SM imprinted PA exhibited more surface area when compared to the control non-imprinted polymer (NIP). In addition, SEM image showed an ordered nano-pattern for the PA of SM that is entirely different from the image of NIP. The imprinting also enhanced SM rebinding ability to the PA when compared to the NIP with an imprinting efficiency (alpha) of 1.3.

  7. China’s Three Warfares Strategy Mitigates Fallout From Cyber Espionage Activities

    Directory of Open Access Journals (Sweden)

    Emilio Iasiello

    2016-06-01

    Full Text Available China is engaged in longstanding cyber espionage against the U.S., as well as other nations, to collect sensitive public and private information in support of national objectives laid out in its 12th Five Year Plan. Foreign governments citing China’s malfeasance have rebuked these activities, a claim vehemently denied by Beijing. In response, China is leveraging the “Three Warfares” an integrated three-prong information warfare strategy to combat these accusations by leveraging Media, Legal, and Psychological components designed to influence the international community. While the United States has threatened the imposition of economic sanctions, Beijing has successfully parried consequential actions by arresting U.S.-identified hackers, thereby demonstrating its commitment toward preserving a stable and peaceful cyberspace. These interrelated “Three Warfares” disciplines have targeted the cognitive processes of the U.S. leadership, as well as the international public’s perception of China as a global threat, thereby having successfully forestalled the implementation of any effective punitive or economic deterrence strategy to include the imposition of cyber sanctions.

  8. Extraordinary Measures: Drone Warfare, Securitization, and the “War on Terror”

    Directory of Open Access Journals (Sweden)

    Romaniuk Scott Nicholas

    2015-07-01

    Full Text Available The use of unmanned aerial vehicles or “drones,” as part of the United States’ (US targeted killing (TK program dramatically increased after the War on Terror (WoT was declared. With the ambiguous nature and parameters of the WoT, and stemming from the postulation of numerous low-level, niche-, and other securitizations producing a monolithic threat, US drone operations now constitute a vital stitch in the extensive fabric of US counterterrorism policy. This article employs the theories of securitization and macrosecuritization as discussed by Buzan (1991, 2006, and Buzan and Wæver (2009 to understand targeted killing, by means of weaponized drones, as an extraordinary measure according to the Copenhagen School’s interpretation. An overarching securitization and the use of the “security” label warrants the emergency action of targeted killing through the use of drones as an extraordinary measure. We argue that the WoT serves as a means of securitizing global terrorism as a threat significant enough to warrant the use of drone warfare as an extraordinary use of force. By accepting the WoT as a securitization process we can reasonably accept that the US’ response(s against that threat are also securitized and therefore become extraordinary measures.

  9. Approximation and Filtering Techniques for Navigation Data in Time-critical Electronic Warfare Systems

    Directory of Open Access Journals (Sweden)

    Vanitha D.

    2013-03-01

    Full Text Available This paper presents a holistic solution to the navigation requirements in a time critical electronic warfare systems like missile warning systems (MWS. In a passive MWS using IR sensors the efficiency of the system is determined by attributes such as low false alarm rate, minimal response time and ability to track different IR radiating objects by association and correlation of consecutive detections through time. Such a system is required to be supported by a navigation system capable of accurate estimation of the aircraft position, attitude angles and altitude. In this paper, estimation techniques used to accurately calculate aircraft navigation data at the time of capture of IR frames are discussed. The paper discusses about synchronization of INGPS, IR sensors & Processor on to same timeline. The paper also intends to evaluate the performance of wavelet transform filter in effective elimination of noise in navigation parameters like acceleration and attitude angle rates for a better estimation of position and attitude.Defence Science Journal, 2013, 63(2, pp.204-209, DOI:http://dx.doi.org/10.14429/dsj.63.4265

  10. Medical effects of internal contamination with actinides: further controversy on depleted uranium and radioactive warfare.

    Science.gov (United States)

    Durakovic, Asaf

    2016-05-01

    The Nuclear Age began in 1945 with testing in New Mexico, USA, and the subsequent bombings of Hiroshima and Nagasaki. Regardless of attempts to limit the development of nuclear weapons, the current world arsenal has reached the staggering dimensions and presents a significant concern for the biosphere and mankind. In an explosion of a nuclear weapon, over 400 radioactive isotopes are released into the biosphere, 40 of which pose potential dangers including iodine, cesium, alkaline earths, and actinides. The immediate health effects of nuclear explosions include thermal, mechanical, and acute radiation syndrome. Long-term effects include radioactive fallout, internal contamination, and long-term genotoxicity. The current controversial concern over depleted uranium's somatic and genetic toxicity is still a subject of worldwide sustained research. The host of data generated in the past decades has demonstrated conflicting findings, with the most recent evidence showing that its genotoxicity is greater than previously considered. Of particular concern are the osteotropic properties of uranium isotopes due to their final retention in the crystals of exchangeable and nonexchangeable bone as well as their proximity to pluripotent stem cells. Depleted uranium remains an unresolved issue in both warfare and the search for alternative energy sources.

  11. Efficacy of liquid and foam decontamination technologies for chemical warfare agents on indoor surfaces.

    Science.gov (United States)

    Love, Adam H; Bailey, Christopher G; Hanna, M Leslie; Hok, Saphon; Vu, Alex K; Reutter, Dennis J; Raber, Ellen

    2011-11-30

    Bench-scale testing was used to evaluate the efficacy of four decontamination formulations on typical indoor surfaces following exposure to the liquid chemical warfare agents sarin (GB), soman (GD), sulfur mustard (HD), and VX. Residual surface contamination on coupons was periodically measured for up to 24h after applying one of four selected decontamination technologies [0.5% bleach solution with trisodium phosphate, Allen Vanguard Surface Decontamination Foam (SDF™), U.S. military Decon Green™, and Modec Inc. and EnviroFoam Technologies Sandia Decontamination Foam (DF-200)]. All decontamination technologies tested, except for the bleach solution, performed well on nonporous and nonpermeable glass and stainless-steel surfaces. However, chemical agent residual contamination typically remained on porous and permeable surfaces, especially for the more persistent agents, HD and VX. Solvent-based Decon Green™ performed better than aqueous-based bleach or foams on polymeric surfaces, possibly because the solvent is able to penetrate the polymer matrix. Bleach and foams out-performed Decon Green for penetrating the highly polar concrete surface. Results suggest that the different characteristics needed for an ideal and universal decontamination technology may be incompatible in a single formulation and a strategy for decontaminating a complex facility will require a range of technologies.

  12. Metabolic Syndrome in Chemical Warfare Patients with Chronic Obstructive Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    Shahrzad M. Lari

    2014-11-01

    Full Text Available   Introduction: Sulfur mustard (SM, a toxic alkylating gas, can cause serious long-term pulmonary complications such as chronic obstructive pulmonary disease (COPD. Metabolic syndrome (MetS is one of the important comorbidities of COPD. This study was designed to evaluate the frequency of metabolic syndrome in Iranian chemical warfare patients (CWPs with COPD. Materials and Methods: Thirty CWPs with a mean age of 46.93± 6.8 were enrolled in this study. The following parameters were studied in: complete pulmonary function tests, health-related quality of life, serum triglycerides (TG, high density lipoprotein (HDL and fasting blood sugar (FBS levels. Additionally, 32 COPD patients and 56 healthy persons were considered as control groups who were matched to CWPs. Results: We found a statistically significant difference in the frequency of MetS between the COPD patients and the healthy control group (p=0.04. Additionally, we observed a statistically significant difference in the mean HDL levels among these groups (p=

  13. Medical effects of internal contamination with actinides: further controversy on depleted uranium and radioactive warfare.

    Science.gov (United States)

    Durakovic, Asaf

    2016-05-01

    The Nuclear Age began in 1945 with testing in New Mexico, USA, and the subsequent bombings of Hiroshima and Nagasaki. Regardless of attempts to limit the development of nuclear weapons, the current world arsenal has reached the staggering dimensions and presents a significant concern for the biosphere and mankind. In an explosion of a nuclear weapon, over 400 radioactive isotopes are released into the biosphere, 40 of which pose potential dangers including iodine, cesium, alkaline earths, and actinides. The immediate health effects of nuclear explosions include thermal, mechanical, and acute radiation syndrome. Long-term effects include radioactive fallout, internal contamination, and long-term genotoxicity. The current controversial concern over depleted uranium's somatic and genetic toxicity is still a subject of worldwide sustained research. The host of data generated in the past decades has demonstrated conflicting findings, with the most recent evidence showing that its genotoxicity is greater than previously considered. Of particular concern are the osteotropic properties of uranium isotopes due to their final retention in the crystals of exchangeable and nonexchangeable bone as well as their proximity to pluripotent stem cells. Depleted uranium remains an unresolved issue in both warfare and the search for alternative energy sources. PMID:27002520

  14. Mass spectrometric study of selected precursors and degradation products of chemical warfare agents.

    Science.gov (United States)

    Papousková, Barbora; Bednár, Petr; Frysová, Iveta; Stýskala, Jakub; Hlavác, Jan; Barták, Petr; Ulrichová, Jitka; Jirkovský, Jaromír; Lemr, Karel

    2007-12-01

    Selected precursors and degradation products of chemical warfare agents namely N,N-dialkylaminoethane-2-ols, N,N-dialkylaminoethyl-2-chlorides and some of related N-quaternary salts were studied by means of electrospray ionization-multiple tandem mass spectrometry (ESI-MS(n)). Proposed structures were confirmed with accurate mass measurement. General fragmentation patterns of these compounds are discussed in detail and suggested processes are confirmed using deuterated standards. The typical processes are elimination of alkene, hydrogen chloride, or water, respectively. Besides, elimination of ethene from propyl chain under specific conditions was observed and unambiguously confirmed using exact mass measurement and labelled standard. The potential of mass spectrometry to distinguish the positional isomers occurring among the studied compounds is reviewed in detail using two different MS instruments (i.e. ion trap and hybrid quadrupole-time of flight (Q-TOF) analyzer). A new microcolumn liquid chromatography (microLC)/MS(n) method was designed for the cases where the resolution based solely on differences in fragmentation is not sufficient. Low retention of the derivatives on reversed phase (RP) was overcome by using addition of less typical ion pairing agent (1 mM/l, 3,5-dinitrobenzoic acid) to the mobile phase (mixture water : acetonitrile). PMID:18085550

  15. Magnetic hydrophilic-lipophilic balance sorbent for efficient extraction of chemical warfare agents from water samples.

    Science.gov (United States)

    Singh, Varoon; Purohit, Ajay Kumar; Chinthakindi, Sridhar; Goud D, Raghavender; Tak, Vijay; Pardasani, Deepak; Shrivastava, Anchal Roy; Dubey, Devendra Kumar

    2016-02-19

    Magnetic hydrophilic-lipophilic balance (MHLB) hybrid resin was prepared by precipitation polymerization using N-vinylpyrrolidone (PVP) and divinylbenzene (DVB) as monomers and Fe2O3 nanoparticles as magnetic material. These resins were successfully applied for the extraction of chemical warfare agents (CWAs) and their markers from water samples through magnetic dispersive solid-phase extraction (MDSPE). By varying the ratios of monomers, resin with desired hydrophilic-lipophilic balance was prepared for the extraction of CWAs and related esters of varying polarities. Amongst different composites Fe2O3 nanoparticles coated with 10% PVP+90% DVB exhibited the best recoveries varying between 70.32 and 97.67%. Parameters affecting the extraction efficiencies, such as extraction time, desorption time, nature and volume of desorption solvent, amount of extraction sorbent and the effect of salts on extraction were investigated. Under the optimized conditions, linearity was obtained in the range of 0.5-500 ng mL(-1) with correlation ranging from 0.9911-0.9980. Limits of detection and limits of quantification were 0.5-1.0 and 3.0-5.0 ng mL(-1) respectively with RSDs varying from 4.88-11.32% for markers of CWAs. Finally, the developed MDSPE method was employed for extraction of analytes from water samples of various sources and the OPCW proficiency test samples. PMID:26814366

  16. Healthcare and warfare. Medical space, mission and apartheid in twentieth century northern Namibia.

    Science.gov (United States)

    Nord, Catharina

    2014-07-01

    In the year 1966, the first government hospital, Oshakati hospital, was inaugurated in northern South-West Africa. It was constructed by the apartheid regime of South Africa which was occupying the territory. Prior to this inauguration, Finnish missionaries had, for 65 years, provided healthcare to the indigenous people in a number of healthcare facilities of which Onandjokwe hospital was the most important. This article discusses these two agents' ideological standpoints. The same year, the war between the South-West African guerrillas and the South African state started, and continued up to 1988. The two hospitals became involved in the war; Oshakati hospital as a part of the South African war machinery, and Onandjokwe hospital as a 'terrorist hospital' in the eyes of the South Africans. The missionary Onandjokwe hospital was linked to the Lutheran church in South-West Africa, which became one of the main critics of the apartheid system early in the liberation war. Warfare and healthcare became intertwined with apartheid policies and aggression, materialised by healthcare provision based on strategic rationales rather than the people's healthcare needs. When the Namibian state took over a ruined healthcare system in 1990, the two hospitals were hubs in a healthcare landscape shaped by missionary ambitions, war and apartheid logic.

  17. Global physics: from percolation to terrorism, guerilla warfare and clandestine activities

    Science.gov (United States)

    Galam, Serge

    2003-12-01

    The September 11 attack on the US has revealed an unprecedented terrorism with worldwide range of destruction. It is argued to result from the first worldwide percolation of passive supporters. They are people sympathetic to the terrorism cause but without being involved with it. They just do not oppose it in case they could. This scheme puts suppression of the percolation as the major strategic issue in the fight against terrorism. Acting on the population is shown to be useless. Instead a new strategic scheme is suggested to increase the terrorism percolation threshold and in turn suppress the percolation. The relevant associated space is identified as a multi-dimensional social space including both the ground earth surface and all various independent flags displayed by the terrorist group. Some hints are given on how to shrink the geographical spreading of terrorism threat. The model apply to a large spectrum of clandestine activities including guerilla warfare as well as tax evasion, corruption, illegal gambling, illegal prostitution and black markets.

  18. Biological Threats

    Science.gov (United States)

    ... Workplace Plans School Emergency Plans Main Content Biological Threats Biological agents are organisms or toxins that can ... for Disease Control and Prevention . Before a Biological Threat Unlike an explosion, a biological attack may or ...

  19. Smart phones: platform enabling modular, chemical, biological, and explosives sensing

    Science.gov (United States)

    Finch, Amethist S.; Coppock, Matthew; Bickford, Justin R.; Conn, Marvin A.; Proctor, Thomas J.; Stratis-Cullum, Dimitra N.

    2013-05-01

    Reliable, robust, and portable technologies are needed for the rapid identification and detection of chemical, biological, and explosive (CBE) materials. A key to addressing the persistent threat to U.S. troops in the current war on terror is the rapid detection and identification of the precursor materials used in development of improvised explosive devices, homemade explosives, and bio-warfare agents. However, a universal methodology for detection and prevention of CBE materials in the use of these devices has proven difficult. Herein, we discuss our efforts towards the development of a modular, robust, inexpensive, pervasive, archival, and compact platform (android based smart phone) enabling the rapid detection of these materials.

  20. Measurement of 100 B. anthracis Ames spores within 15 minutes by SERS at the US Army Edgewood Chemical Biological Ctr.

    Science.gov (United States)

    Farquharson, Stuart; Shende, Chetan; Smith, Wayne; Huang, Hermes; Sperry, Jay; Sickler, Todd; Prugh, Amber; Guicheteau, Jason

    2014-05-01

    Since the distribution of Bacillus anthracis-Ames spores through the US Postal System, there has been a persistent fear that biological warfare agents will be used by terrorists against our military abroad and our civilians at home. While there has been substantial effort since the anthrax attack of 2001 to develop analyzers to detect this and other biological warfare agents, the analyzers remain either too slow, lack sensitivity, produce high false-positive rates, or cannot be fielded. In an effort to overcome these limitations we have been developing a surface-enhanced Raman spectroscopy system. Here we describe the use of silver nanoparticles functionalized with a short peptide to selectively capture Bacillus anthracis spores and produce SER scattering. Specifically, measurements of 100 B. anthracis-Ames spores/mL in ~25 minutes performed at the US Army's Edgewood Chemical Biological Center are presented. The measurements provide a basis for the development of systems that can detect spores collected from the air or water supplies with the potential of saving lives during a biological warfare attack.

  1. Modern warfare as a significant form of zoogeomorphic disturbance upon the landscape

    Science.gov (United States)

    Hupy, Joseph P.; Koehler, Thomas

    2012-07-01

    The damage exerted by warfare on the physical landscape is one, of many, anthropogenic impacts upon the environment. Bombturbation is a term that describes the impacts of explosive munitions upon the landscape. Bombturbation, like many other forms of zoogeomorphology, is a disruptive force, capable of moving large amounts of sediments, and denuding landscapes to the point where changes in micro and mesotopography have long-term implications. The long term implication of bombturbative actions depends on the type and duration of explosive device that rendered the disturbance, and the geographic context of the landscape disturbed; i.e. cultural and physical factors. Recovery from bombturbative activity, in the context of this research, is measured by vegetative regrowth and soil development in cratered disturbances. A comparison and contrast between the two battlefields of Verdun, France and Khe Sanh, Vietnam show that bombturbative actions have significantly altered the topography at each location, thus influencing surface runoff and processes of soil development. Principals of the Runge pedogenic model, or the energy of water moving through the soil profile, best explain how the varying climate and parent material at each location influence post disturbance soil development rates. Whereas the data collected at Verdun suggest that explosive munitions have put that landscape on diverging path of development, thus rendering it much different post-disturbance landscape, Khe Sanh displays much different recovery patterns. Preliminary research at Khe Sanh indicates that reforestation and soil development following disturbance are not so much influenced by bombturbative patterns as land use activities in the area of study.

  2. Limitations and challenges in treatment of acute chemical warfare agent poisoning.

    Science.gov (United States)

    Thiermann, Horst; Worek, Franz; Kehe, Kai

    2013-12-01

    Recent news from Syria on a possible use of chemical warfare agents made the headlines. Furthermore, the motivation of terrorists to cause maximal harm shifts these agents into the public focus. For incidents with mass casualties appropriate medical countermeasures must be available. At present, the most important threats arise from nerve agents and sulfur mustard. At first, self-protection and protection of medical units from contamination is of utmost importance. Volatile nerve agent exposure, e.g. sarin, results in fast development of cholinergic crisis. Immediate clinical diagnosis can be confirmed on-site by assessment of acetylcholinesterase activity. Treatment with autoinjectors that are filled with 2mg atropine and an oxime (at present obidoxime, pralidoxime, TMB-4 or HI-6) are not effective against all nerve agents. A more aggressive atropinisation has to be considered and more effective oximes (if possible with a broad spectrum or a combination of different oximes) as well as alternative strategies to cope with high acetylcholine levels at synaptic sites should be developed. A further gap exists for the treatment of patients with sustained cholinergic crisis that has to be expected after exposure to persistent nerve agents, e.g. VX. The requirement for long-lasting artificial ventilation can be reduced with an oxime therapy that is optimized by using the cholinesterase status for guidance or by measures (e.g. scavengers) that are able to reduce the poison load substantially in the patients. For sulfur mustard poisoning no specific antidote is available until now. Symptomatic measures as used for treatment of burns are recommended together with surgical or laser debridement. Thus, huge amounts of resources are expected to be consumed as wound healing is impaired. Possible depots of sulfur mustard in tissues may aggravate the situation. More basic knowledge is necessary to improve substantially therapeutic options. The use of stem cells may provide a new

  3. Treatment of chemical warfare agents by zero-valent iron nanoparticles and ferrate(VI)/(III) composite

    International Nuclear Information System (INIS)

    Highlights: ► Ferrate(VI) has been found to be highly efficient to decontaminate chemical warfare agents. ► Fast degradation of sulfur mustard, soman and compound VX by ferrate(VI). ► Nanoscale zero-valent iron particles are considerably less efficient in degradation of studied warfare agents compared to ferrate(VI). - Abstract: Nanoscale zero-valent iron (nZVI) particles and a composite containing a mixture of ferrate(VI) and ferrate(III) were prepared by thermal procedures. The phase compositions, valence states of iron, and particle sizes of iron-bearing compounds were determined by combination of X-ray powder diffraction, Mössbauer spectroscopy and scanning electron microscopy. The applicability of these environmentally friendly iron based materials in treatment of chemical warfare agents (CWAs) has been tested with three representative compounds, sulfur mustard (bis(2-chlorethyl) sulfide, HD), soman ((3,3′-imethylbutan-2-yl)-methylphosphonofluoridate, GD), and O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate (VX). Zero-valent iron, even in the nanodimensional state, had a sluggish reactivity with CWAs, which was also observed in low degrees of CWAs degradation. On the contrary, ferrate(VI)/(III) composite exhibited a high reactivity and complete degradations of CWAs were accomplished. Under the studied conditions, the estimated first-order rate constants (∼10−2 s−1) with the ferrate(VI)/(III) composite were several orders of magnitude higher than those of spontaneous hydrolysis of CWAs (10−8–10−6 s−1). The results demonstrated that the oxidative technology based on application of ferrate(VI) is very promising to decontaminate CWAs.

  4. Information Warfare and New Organizational Landscapes: An Inquiry into the ExxonMobil–Greenpeace Dispute over Climate Change

    OpenAIRE

    Mackay, Brad; Munro, I.

    2012-01-01

    A defining characteristic of the emergence of new organizational landscapes is that information is not just being used as a tool by organizations, as it is more usually understood, but also as a weapon in a ‘war of position’. As organizations seek to influence public perception over such emotive issues as climate change, conflict at the ideation level can give rise to information warfare campaigns. In this article, we analyse the ways in which ExxonMobil and Greenpeace employ distinctive info...

  5. Investigations of emergency destruction methods for recovered, explosively configured, chemical warfare munitions: Interim emergency destruction methods - evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    Baer, M.R.; Cooper, P.W.; Kipp, M.E. [and others

    1995-07-01

    At the request of the U.S. Army Non-Stockpile Chemical Material Office, the Sandia Explosives Containment System Design Team investigated mature destruction systems for destroying recovered chemical warfare munitions (CWM). The goal of the investigations was to identify and examine available techniques for the destruction of recovered CWM. The result of this study is a recommendation for an interim solution, a solution for use on any munitions found while an optimal, long-term solution is developed. Sandia is also performing the long-term solution study to develop a system that destroys CWM, contains the blast and fragments, and destroys the chemical agent without insult to the environment.

  6. 竞技排球运动心理战理论模型的构建%Theoretical Models of Psychological Warfare Built in Competitive Volleyball

    Institute of Scientific and Technical Information of China (English)

    洪庆

    2011-01-01

    通过对军事心理学中心理战思想的精心研读,结合竞技排球运动与战场心理战的共通之处,从理论建设、专业人才建设、规章制度建设、谋略创新建设以及球队心理素质建设五个方面构建了竞技排球运动心理战的理论模型。%This article through the study of thoughts of psychological warfare in military psychology carefully, combined with the commons of volleyball and psychological warfare, from five aspects that construction of theory, construction of professional, and construction of rules and regulations, construction of counsel innovation and construction of team psychological quality to construct the theoretical model of psychological warfare of volleyball.

  7. Synthetic biology and biosecurity: challenging the "myths".

    Science.gov (United States)

    Jefferson, Catherine; Lentzos, Filippa; Marris, Claire

    2014-01-01

    Synthetic biology, a field that aims to "make biology easier to engineer," is routinely described as leading to an increase in the "dual-use" threat, i.e., the potential for the same scientific research to be "used" for peaceful purposes or "misused" for warfare or terrorism. Fears have been expressed that the "de-skilling" of biology, combined with online access to the genomic DNA sequences of pathogenic organisms and the reduction in price for DNA synthesis, will make biology increasingly accessible to people operating outside well-equipped professional research laboratories, including people with malevolent intentions. The emergence of do-it-yourself (DIY) biology communities and of the student iGEM competition has come to epitomize this supposed trend toward greater ease of access and the associated potential threat from rogue actors. In this article, we identify five "myths" that permeate discussions about synthetic biology and biosecurity, and argue that they embody misleading assumptions about both synthetic biology and bioterrorism. We demonstrate how these myths are challenged by more realistic understandings of the scientific research currently being conducted in both professional and DIY laboratories, and by an analysis of historical cases of bioterrorism. We show that the importance of tacit knowledge is commonly overlooked in the dominant narrative: the focus is on access to biological materials and digital information, rather than on human practices and institutional dimensions. As a result, public discourse on synthetic biology and biosecurity tends to portray speculative scenarios about the future as realities in the present or the near future, when this is not warranted. We suggest that these "myths" play an important role in defining synthetic biology as a "promissory" field of research and as an "emerging technology" in need of governance. PMID:25191649

  8. Biological restoration of major transportation facilities domestic demonstration and application project (DDAP): technology development at Sandia National Laboratories.

    Energy Technology Data Exchange (ETDEWEB)

    Ramsey, James L., Jr. (.,; .); Melton, Brad; Finley, Patrick; Brockman, John; Peyton, Chad E.; Tucker, Mark David; Einfeld, Wayne; Griffith, Richard O.; Brown, Gary Stephen; Lucero, Daniel A.; Betty, Rita G.; McKenna, Sean Andrew; Knowlton, Robert G.; Ho, Pauline

    2006-06-01

    The Bio-Restoration of Major Transportation Facilities Domestic Demonstration and Application Program (DDAP) is a designed to accelerate the restoration of transportation nodes following an attack with a biological warfare agent. This report documents the technology development work done at SNL for this DDAP, which include development of the BROOM tool, an investigation of surface sample collection efficiency, and a flow cytometry study of chlorine dioxide effects on Bacillus anthracis spore viability.

  9. Research on the Interaction of Hydrogen-Bond Acidic Polymer Sensitive Sensor Materials with Chemical Warfare Agents Simulants by Inverse Gas Chromatography

    Directory of Open Access Journals (Sweden)

    Liu Yang

    2015-06-01

    Full Text Available Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction. DMMP (a nerve gas simulant and 2-CEES (a blister agent simulant were used as probes. Chemical and physical parameters such as heats of absorption and Henry constants of the polymers to DMMP and 2-CEES were determined by inverse gas chromatography. Details concerning absorption performance are also discussed in this paper.

  10. Coalition Warfare Program (CWP): secure policy controlled information query and dissemination over a Bices network

    Science.gov (United States)

    Toth, Andrew; Pham, Tien; Karr, Todd; Bent, Graham; Harries, Dominic; Knox, Alan

    2013-05-01

    In 2006, the US Army Research Laboratory (ARL) and the UK Ministry of Defence (MoD) established a collaborative research alliance with academia and industry, called the International Technology Alliance (ITA) to address fundamental issues concerning Network and Information Sciences. Under the ITA research program, a US-UK transition project on "ITA Policy Controlled Information Query and Dissemination" was funded in 2011 by OSD's Coalition Warfare Program (CWP). The goal of this CWP project is to develop an extensible capability of performing distributed federated query and information dissemination across a coalition network of distributed disparate data/information sources with access­ controlled policies. The CWP project is lead by US Army Research Laboratory (ARL) and UK Defence Science Technology Laboratory (Dstl) with software development by IBM UK and IBM US. The CWP project exploits two key technology components developed within the ITA, namely the Gaian Database and integrated Access Policy Decision and Enforcement mechanisms. The Gaian Database (GaianDB) is a Dynamic Distributed Federated Database (DDFD) that addresses a need to share information among coalition members by providing a means for policy-controlled access to data across a network of heterogeneous data sources. GaianDB implements a SQL-compliant Store-Locally-Query-Anywhere (SLQA) approach providing software applications with global access to data from any node in the database network via standard SQL queries. Security policy is stored locally and enforced at the database node level, reducing potential for unauthorized data access and waste of network bandwidth. A key metric of success for a CWP project is the transition of coalition-related technology from TRL-3 or 4 to TRL-6 or higher. Thus, the end goal of this CWP project was to demonstrate the GaianDB and policy technology within an operational environment at the NATO Intelligence Fusion Centre (NIFC) at Molesworth RAF. An initial

  11. Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Davood Attaran

    2010-09-01

    disease, interleukin-6, inflammation, chemical warfare

  12. Secondary ionization of chemical warfare agent simulants: atmospheric pressure ion mobility time-of-flight mass spectrometry.

    Science.gov (United States)

    Steiner, Wes E; Clowers, Brian H; Haigh, Paul E; Hill, Herbert H

    2003-11-15

    For the first time, the use of a traditional ionization source for ion mobility spectrometry (radioactive nickel ((63)Ni) beta emission ionization) and three alternative ionization sources (electrospray ionization (ESI), secondary electrospray ionization (SESI), and electrical discharge (corona) ionization (CI)) were employed with an atmospheric pressure ion mobility orthogonal reflector time-of-flight mass spectrometer (IM(tof)MS) to detect chemical warfare agent (CWA) simulants from both aqueous- and gas-phase samples. For liquid-phase samples, ESI was used as the sample introduction and ionization method. For the secondary ionization (SESI, CI, and traditional (63)Ni ionization) of vapor-phase samples, two modes of sample volatilization (heated capillary and thermal desorption chamber) were investigated. Simulant reference materials, which closely mimic the characteristic chemical structures of CWA as defined and described by Schedule 1, 2, or 3 of the Chemical Warfare Convention treaty verification, were used in this study. A mixture of four G/V-type nerve simulants (dimethyl methylphosphonate, pinacolyl methylphosphonate, diethyl phosphoramidate, and 2-(butylamino)ethanethiol) and one S-type vesicant simulant (2-chloroethyl ethyl sulfide) were found in each case (sample ionization and introduction methods) to be clearly resolved using the IM(tof)MS method. In many cases, reduced mobility constants (K(o)) were determined for the first time. Ion mobility drift times, flight times, relative signal intensities, and fragmentation product signatures for each of the CWA simulants are reported for each of the methods investigated. PMID:14615983

  13. Founding of Japanese Biological Warfare Unit and Its Germ Warfare in China%日军细菌战部队的建立及对华细菌战

    Institute of Scientific and Technical Information of China (English)

    奈须重雄; 谢彩虹

    2015-01-01

    昭和7年(1932)8月8日至9月30日,石井四郎率陆军军医学校防疫研究室人员“出差”到中国东北对当年“袭击全满洲”的流行霍乱病进行“调查”,这次所谓的“调查”对于日军细菌战部队的前身“东乡部队”在中国东北背荫河地区的建立有重要的“意义”.1940年日军实施的“金华细菌战”,中国档案缺乏受害记录,但在日本发现了金华鼠疫受害的一些资料.“农安和农安大赉细菌战”是1940年日军实施的一次诡秘的细菌战,其目的是实验在历史上鼠疫常发地带的细菌战效果.1942年日军在衢县和丽水投放的“PA跳蚤”与在广信、广丰、玉山投放的“PX跳蚤”的区别在哪里?“A”代表普通跳蚤,“X”代表印度客蚤.日军实施细菌战的方法有四类:飞机执行法、火炮执行法、与化学兵器并用法、谋略法;但目前知道的只有飞机执行法和谋略法的细菌战实例,而火炮执行法、与化学兵器并用法的细菌战实例尚未发现.

  14. Biological computation

    CERN Document Server

    Lamm, Ehud

    2011-01-01

    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  15. Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield.

    Science.gov (United States)

    Knudson, Gregory B; Elliott, Thomas B; Brook, Itzhak; Shoemaker, Michael O; Pastel, Ross H; Lowy, Robert J; King, Gregory L; Herzig, Thomas C; Landauer, Michael R; Wilson, Scott A; Peacock, Susan J; Bouhaouala, S Samy; Jackson, William E; Ledney, G David

    2002-02-01

    The Armed Forces Radiobiological Research Institute (AFRRI) has developed a research program to determine the major health risks from exposure to ionizing radiation in combination with biological and chemical warfare agents and to assess the extent to which exposure to ionizing radiation compromises the effectiveness of protective drugs, vaccines, and other biological and chemical warfare prophylactic and treatment strategies. AFRRI's Defense Technology Objective MD22 supports the development of treatment modalities and studies to assess the mortality rates for combined injuries from exposure to ionizing radiation and Bacillus anthracis, and research to provide data for casualty prediction models that assess the health consequences of combined exposures. In conjunction with the Defense Threat Reduction Agency, our research data are contributing to the development of casualty prediction models that estimate mortality and incapacitation in an environment of radiation exposure plus other weapons of mass destruction. Specifically, the AFFRI research program assesses the effects of ionizing radiation exposure in combination with B. anthracis, Venezuelan equine encephalomyelitis virus, Shigella sonnei, nerve agents, and mustard as well as their associated treatments and vaccines. In addition, the long-term psychological effects of radiation combined with nuclear, biological, and chemical (NBC) injuries are being evaluated. We are also assessing the effectiveness of gamma photons and high-speed neutrons and electrons for neutralizing biological and chemical warfare agents. New protocols based on our NBC bioeffects experiments will enable U.S. armed forces to accomplish military operations in NBC environments while optimizing both survival and military performance. Preserving combatants' health in an NBC environment will improve warfighting operations and mission capabilities.

  16. Evaluation of Molecular Markers and Analytical Methods Documenting the Occurrence of Mustard Gas and Arsenical Warfare Agents in Soil.

    Science.gov (United States)

    Sassolini, Alessandro; Brinchi, Giampaolo; Di Gennaro, Antonio; Dionisi, Simone; Dominici, Carola; Fantozzi, Luca; Onofri, Giorgio; Piazza, Rosario; Guidotti, Maurizio

    2016-09-01

    The chemicals warfare agents (CWAs) are an extremely toxic class of molecules widely produced in many industrialized countries for decades, these compounds frequently contained arsenic. The plants where the CWAs have been produced or the plants where they have been demilitarized after the Second World War with unacceptable techniques can represent a serious environmental problem. CWAs standards are difficult to find on market so in present work an environmental assessment method based on markers has been proposed. Triphenylarsine, phenylarsine oxide and thiodiglycol have been selected as markers. Three reliable analytical methods based on gaschromatography and mass detection have been proposed and tested for quantitative analysis of markers. Methods performance have been evaluated testing uncertainty, linearity, recovery and detection limits and also comparing detection limits with exposure limits of reference CWAs. Proposed assessment methods have been applied to a case study of a former industrial plant sited in an area characterized by a high background of mineral arsenic. PMID:27385368

  17. 网络电磁空间作战威胁分析%Analysis of Cyber Electromagnetic Space Warfare Threat

    Institute of Scientific and Technical Information of China (English)

    栾胜利

    2014-01-01

    提出了网电空间作战几个需要关注的问题以及解决方案,使得部队可以根据战场具体环境,进行适应性的应用。首先陈述了网电空间作战的特点,接着阐述了在网电空间中军队所要面临、应对的现实威胁。然后针对这些威胁进行了进一步分析,并且确定了战场环境下所需要的基础安全条件。最后从四个层面阐述了网电空间的脆弱性,同时给出了防御措施。该工作可以对确立可实施的网电空间战术以及有效地组织网电空间行动形成支撑。%A cyber warfare scenario is shown ,which is applicable on the basis of modern battlefield situations .The sce-nario removes misconceptions about present cyber warfare properties and defines actual dangers that should be prepared for in the background of the cyberspace .The dangers are analyzed further and the basic security prerequisites are determined . Technologies are proposed that offer the basic necessary for achieving these prerequisites .An organization of cyberspace weaknesses and the correlative defenses in four levels is shown .Conclusions are drawn that demonstrate the manner in which cyber threats should be determined ,their likelihood assessed and averted .This knowledge leads to the determination of im-plementable cyber tactics and effective organization of cyber operations .

  18. Temperate bacterial viruses as double-edged swords in bacterial warfare.

    Science.gov (United States)

    Gama, João Alves; Reis, Ana Maria; Domingues, Iolanda; Mendes-Soares, Helena; Matos, Ana Margarida; Dionisio, Francisco

    2013-01-01

    It has been argued that bacterial cells may use their temperate viruses as biological weapons. For instance, a few bacterial cells among a population of lysogenic cells could release the virus and kill susceptible non-lysogenic competitors, while their clone mates would be immune. Because viruses replicate inside their victims upon infection, this process would amplify their number in the arena. Sometimes, however, temperate viruses spare recipient cells from death by establishing themselves in a dormant state inside cells. This phenomenon is called lysogenization and, for some viruses such as the λ virus, the probability of lysogenization increases with the multiplicity of infection. Therefore, the amplification of viruses leads to conflicting predictions about the efficacy of temperate viruses as biological weapons: amplification can increase the relative advantage of clone mates of lysogens but also the likelihood of saving susceptible cells from death, because the probability of lysogenization is higher. To test the usefulness of viruses as biological weapons, we performed competition experiments between lysogenic Escherichia coli cells carrying the λ virus and susceptible λ-free E. coli cells, either in a structured or unstructured habitat. In structured and sometimes in unstructured habitats, the λ virus qualitatively behaved as a "replicating toxin". However, such toxic effect of λ viruses ceased after a few days of competition. This was due to the fact that many of initially susceptible cells became lysogenic. Massive lysogenization of susceptible cells occurred precisely under the conditions where the amplification of the virus was substantial. From then on, these cells and their descendants became immune to the λ virus. In conclusion, if at short term bacterial cells may use temperate viruses as biological weapons, after a few days only the classical view of temperate bacterial viruses as parasitic agents prevails. PMID:23536852

  19. Temperate bacterial viruses as double-edged swords in bacterial warfare.

    Directory of Open Access Journals (Sweden)

    João Alves Gama

    Full Text Available It has been argued that bacterial cells may use their temperate viruses as biological weapons. For instance, a few bacterial cells among a population of lysogenic cells could release the virus and kill susceptible non-lysogenic competitors, while their clone mates would be immune. Because viruses replicate inside their victims upon infection, this process would amplify their number in the arena. Sometimes, however, temperate viruses spare recipient cells from death by establishing themselves in a dormant state inside cells. This phenomenon is called lysogenization and, for some viruses such as the λ virus, the probability of lysogenization increases with the multiplicity of infection. Therefore, the amplification of viruses leads to conflicting predictions about the efficacy of temperate viruses as biological weapons: amplification can increase the relative advantage of clone mates of lysogens but also the likelihood of saving susceptible cells from death, because the probability of lysogenization is higher. To test the usefulness of viruses as biological weapons, we performed competition experiments between lysogenic Escherichia coli cells carrying the λ virus and susceptible λ-free E. coli cells, either in a structured or unstructured habitat. In structured and sometimes in unstructured habitats, the λ virus qualitatively behaved as a "replicating toxin". However, such toxic effect of λ viruses ceased after a few days of competition. This was due to the fact that many of initially susceptible cells became lysogenic. Massive lysogenization of susceptible cells occurred precisely under the conditions where the amplification of the virus was substantial. From then on, these cells and their descendants became immune to the λ virus. In conclusion, if at short term bacterial cells may use temperate viruses as biological weapons, after a few days only the classical view of temperate bacterial viruses as parasitic agents prevails.

  20. 未来海上信息战的舰载雷达技术发展研究%Development of Shipborne Radar Technology in Future Information Warfare

    Institute of Scientific and Technical Information of China (English)

    李爱文

    2015-01-01

    This paper first analyzes the demand of shipborne radar in the future information warfare at sea .And then the development ideas about shipborne radar technique adapted for future information warfare at sea are elaborated including shipborne radar networking ,multi‐sensor information fusion ,shipborne electronic equipment integration .%从未来海上信息战对舰载雷达提出的要求出发,阐述了适应未来海上信息战的舰载雷达技术发展思路:舰载雷达组网、多传感器信息融合、与舰载电子设备的一体化和集成化等。

  1. Factors influencing the sustained-performance capabilities of 155-mm howitzer sections in simulated conventional and chemical warfare environments. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, T.M.; Banderet, L.E.; Tharion, W.J.; Munro, I.; Lussier, A.R.

    1986-04-01

    Factors that limit the performance capabilities of sustained artillery operations in simulated conventional and chemical warfare environments were studied. The results show that perceptions of psychological (mental) fatigue, rather than perceptions of muscular fatigue, were primary factors affecting sustained artillery performance. Furthermore, variations in these psychological states were correlated with artillery task performance during the period. In the simulated chemical warfare environment, extreme symptom and mood changes resulted in medical casualties, combat ineffectiveness, and early termination of all testing. Significant perosnality differences existed between casualties and survivors. The majority of casualties voluntarily terminated operational duties because of intense symptoms associated with wearing the chemical protective mask and clothing system. These symptoms were manifestations of respiratory and thermal stress.

  2. Assessing victory: how to identify the correct measures of success in counterinsurgency warfare-the case of the FARC in Colombia

    OpenAIRE

    Korn, Alexander B.

    2013-01-01

    Approved for public release; distribution is unlimited This thesis applies net assessment to the Colombian Governments protracted campaign against the Revolutionary Armed Forces of Colombia (FARC) in order to determine proper metrics to track progress in counterinsurgency warfare. Net assessment is used to analyze potential centers of gravity to determine the correct center of gravity. Armed with the correct center of gravity, potential critical vulnerabilities are examined. Finally, once ...

  3. How Do I Know? A Guide to the Selection of Personal Protective Equipment for Use in Responding to A Release of Chemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    Foust, C.B.

    1999-05-01

    An incident involving chemical warfare agents requires a unique hazardous materials (HAZMAT) response. As with an HAZMAT event, federal regulations prescribe that responders must be protected from exposure to the chemical agents. But unlike other HAZMAT events, special considerations govern selection of personal protective equipment (PPE). PPE includes all clothing, respirators and monitoring devices used to respond to a chemical release. PPE can differ depending on whether responders are military or civilian personnel.

  4. 数据挖掘在现代作战中的应用研究%Research on the Application of Data Mining to Modern Warfare

    Institute of Scientific and Technical Information of China (English)

    张剑

    2012-01-01

    随着装备技术的发展,现代作战具有作战单元种类数量多、攻防战术复杂、干扰性欺骗性数据充斥等特点,尤其是协同作战能力和数据交换能力逐步增强,以上都使得现代作战中涉及的信息呈现“海量”特征.为了取得理想的作战效果,指挥员必须对以上海量信息进行处理,从中提取出有用的信息和知识.近年来迅速发展的数据挖掘技术,在处理海量信息方面具有非常明显的优势.文章在介绍现代作战特点和数据挖掘技术的基础上,对数据挖掘技术在现代作战中的应用做了初步的研究.%The development of equipment technology makes the modern warfare has large numbers and many types of combat units, more complex offensive and defensive tactics, so full of interference and fraudulent data, and especially the cooperative engagement capability and data exchange capability are gradually increasing. Above features lead to massive information involved in modern warfare. In order to a-chieve the desired combat effect, commanders must handle massive information involved to extract useful information and knowledge. Data mining technology which is developing rapidly in recent years has a big advantage in handling massive information. This paper describes the characteristics of modern warfare and data mining technology, and makes a preliminary study on the application of data mining technology to modem warfare.

  5. 大数据在现代战争中的价值探析%Research on the Big Data’s Value in Modern Warfare

    Institute of Scientific and Technical Information of China (English)

    李新乐

    2014-01-01

    Modern warfare is information-dominated. Information penetrates the all aspects of the warfare and becomes one of the key factors which influence the success of the warfare. Effective acquisition, storage, processing and distribution of military in-formation via big data technology can promote the ability of intelligence acquisition and command decision-making, handle the choke point of information flow, advance the integration of operational system, and strengthen the information security and pro-tection.%现代战争是“信息主导”的战争,信息渗透到战争的方方面面,成为影响战争胜负的重要因素之一,利用大数据技术对军事信息进行高效获取、存储、处理和分发,能够有效提升情报获取、指挥决策能力,疏通信息流瓶颈,推进作战体系融合,增强信息安全防护能力。

  6. Warfare and Socio-political hierarchies: reflections on non-State societies of the predynastic Nile Valley

    Directory of Open Access Journals (Sweden)

    Gayubas, Augusto

    2015-12-01

    Full Text Available In a recent article, anthropologist Robert L. Carneiro reassessed his most debated hypothesis about the emergence of chiefdoms and the State as a result of environmental or social circumscription, theorized for a series of historical contexts including that of the Predynastic Nile Valley. The problem of the origin of the State is beyond our scope, but regarding the emergence of institutionalized leadership and chiefdoms in the Nile Valley, Carneiro’s ideas about warfare as a main factor in the process of social change remain interesting, even when his insistence in circumscription is still debatable. The aim of the present paper is to briefly review the available archaeological evidence of warfare among non-State societies of the Predynastic Nile Valley, and to evaluate its possible relation to the emergence of socio-political hierarchies, in turn refering to and criticizing some of Carneiro’s recent ideas about the issue.En un artículo reciente, Robert L. Carneiro presentó una reconsideración de su muy debatida hipótesis acerca de la emergencia de sociedades de jefatura y del Estado como resultado de un contexto de circunscripción ambiental, teorizada para una serie de situaciones históricas, entre ellas el valle del Nilo predinástico. El problema del origen del Estado excede las posibilidades de este trabajo, pero en lo que respecta al surgimiento de jefaturas, consideramos que las ideas de Carneiro acerca de la guerra como factor de importancia en el proceso revisten cierto interés, aun cuando su insistencia en la circunscripción continúa siendo discutible. El objetivo del presente artículo es considerar la evidencia arqueológica de guerra disponible para las sociedades no estatales del valle del Nilo predinástico y evaluar la posible relación entre dichos testimonios y la emergencia de jerarquías sociopolíticas, refiriendo y criticando algunas de las ideas recientes de Carneiro sobre el problema.

  7. The Findings of HRCT of the Lung in Chemical Warfare Veterans with Previous Sulfur Mustard (SM Gas Exposure

    Directory of Open Access Journals (Sweden)

    Saeed Naghibi

    2009-01-01

    Full Text Available "nIntroduction: To identify the findings of High-Resolution Computed Tomography (HRCT of the lung in chemical warfare veterans with previous sulfur mustard (SM gas exposure. "nMaterials and Methods: 93 patients were studied prospectively 22 years after exposure. Demographic and clinical data were recorded. HRCT of the lung was performed during expiration and was reported double blinded by two radiologists. HRCT findings include air trapping, mosaic attenuation, ground glass attenuation, nodules, signet ring, fibrosis, bronchial wall thickening, bronchodilation, tree in bud, interlobular wall thickening, bulla, cavity, air consolidation, honey comb and mediastinal and pleural abnormalities that were analyzed. Final diagnosis was identified according to HRCT findings. The relation between HRCT findings, final diagnosis and the distribution of the abnormalities with duration after exposure were evaluated. Distribution of each finding was also evaluated. "nb The most frequent HRCT finding was air trapping (56.7%. Other common findings were mosaic attenuation (35.1%, ground glass attenuation (20.6%, nodules (17.5%, signet ring (15.5% and fibrosis(12.4%. Distribution of the abnormalities were mostly local (79.4% and bilateral (73%. Abnormalities were mostly in the lower lobe (61.3%. No significant correlation was found between the HRCT findings and the duration after exposure or distribution of the abnormalities. The respiratory complications diagnosed according to HRCT included bronchiolitis obliterans (43%, chronic obstructive pulmonary disease (COPD (27.9%, asthma (23.6%, bronchiectasis (13.9%, interstitial lung disease (ILD (9.6%. All abnormalities were seen more frequently in patients with lesser duration of exposure.( P-value < 0.05. "nConclusion: Focal bilateral air trapping was the most common finding seen in expiratory HRCT in this study, and it is highly suggestive of bronchiolitis obliterance (BO. BO can be a late complication of SM

  8. Is synthetic biology mechanical biology?

    Science.gov (United States)

    Holm, Sune

    2015-12-01

    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  9. Biology Notes.

    Science.gov (United States)

    School Science Review, 1982

    1982-01-01

    Presents procedures, exercises, demonstrations, and information on a variety of biology topics including labeling systems, biological indicators of stream pollution, growth of lichens, reproductive capacity of bulbous buttercups, a straw balance to measure transpiration, interaction of fungi, osmosis, and nitrogen fixation and crop production. (DC)

  10. Child Soldiery as a Tool of Modern Warfare(?: the Role of Child Soldiers in “New Wars”

    Directory of Open Access Journals (Sweden)

    Dóra SZIJJ

    2010-12-01

    Full Text Available The hardly-known but regrettably prevalent phenomenon of child soldiery, which can be considered as a new development of modern warfare, might affect approximately 250,000 – 300,000 children worldwide. According to the estimates, 40% of our planet’s armed forces or armed groups deploy “child combatants” for different tasks, while the international community is still struggling against this form of the abuse of children. The global nature of child soldiery raises many questions in many fields, because it has deep political, social, economic, military, environmental, ethnic and religious etc. roots and far reaching consequences in the so-called Third World. Moreover, if we focus on the African peacekeeping missions of the European Union, child soldiery might also have indirect impacts on the European community. The aim of this study is to offer a comprehensive approach in connection with child soldiery, and pointing out the links between the post-colonial conflicts and this form of human rights breaches.

  11. Maximum Likelihood Estimator for Bearings-only Passive Target Tracking in Electronic Surveillance Measure and Electronic Warfare Systems

    Directory of Open Access Journals (Sweden)

    S. Koteswara Rao

    2010-03-01

    Full Text Available Maximum likelihood estimator is a suitable algorithm for passive target tracking applications. Nardone, Lindgren and Gong introduced this approach using batch processing. In this paper, the batch processing is converted into sequential processing for real-time applications like passive target tracking using bearings-only measurements. Adaptively, the variance of each measurement is computed and is used along with the measurement in such a way that the effect of false bearings can be reduced. The transmissions made by radar on a target ship are assumed to be intercepted by an electronic warfare (EW system of own ship. The generated bearings in intercept mode are processed through maximum likelihood estimator (MLE to find out target motion parameters. Instead of assuming some arbitrary values, pseudo linear estimator outputs are used for the initialisation of MLE. The algorithm is tested in Monte-Carlo simulation and its results are presented for two typical scenarios.Defence Science Journal, 2010, 60(2, pp.197-203, DOI:http://dx.doi.org/10.14429/dsj.60.340

  12. Distribution of chemical warfare agent, energetics, and metals in sediments at a deep-water discarded military munitions site

    Science.gov (United States)

    Briggs, Christian; Shjegstad, Sonia M.; Silva, Jeff A. K.; Edwards, Margo H.

    2016-06-01

    There is a strong need to understand the behavior of chemical warfare agent (CWA) at underwater discarded military munitions (DMM) sites to determine the potential threat to human health or the environment, yet few studies have been conducted at sites in excess of 250 m, the depth at which most U.S. chemical munitions were disposed. As part of the Hawai'i Undersea Military Munitions Assessment (HUMMA), sediments adjacent to chemical and conventional DMM at depths of 400-650 m were sampled using human occupied vehicles (HOVs) in order to quantify the distribution of CWA, energetics, and select metals. Sites in the same general area, with no munitions within 50 m in any direction were sampled as a control. Sulfur mustard (HD) and its degradation product 1,4-dithiane were detected at each CWA DMM site, as well as a single sample with the HD degradation product 1,4-thioxane. An energetic compound was detected in sediment to a limited extent at one CWA DMM site. Metals common in munitions casings (i.e., Fe, Cu, and Pb) showed similar trends at the regional and site-wide scales, likely reflecting changes in marine sediment deposition and composition. This study shows HD and its degradation products can persist in the deep-marine environment for decades following munitions disposal.

  13. The application of single particle aerosol mass spectrometry for the detection and identification of high explosives and chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Audrey Noreen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2006-01-01

    Single Particle Aerosol Mass Spectrometry (SPAMS) was evaluated as a real-time detection technique for single particles of high explosives. Dual-polarity time-of-flight mass spectra were obtained for samples of 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazinane (RDX), and pentaerythritol tetranitrate (PETN); peaks indicative of each compound were identified. Composite explosives, Comp B, Semtex 1A, and Semtex 1H were also analyzed, and peaks due to the explosive components of each sample were present in each spectrum. Mass spectral variability with laser fluence is discussed. The ability of the SPAMS system to identify explosive components in a single complex explosive particle (~1 pg) without the need for consumables is demonstrated. SPAMS was also applied to the detection of Chemical Warfare Agent (CWA) simulants in the liquid and vapor phases. Liquid simulants for sarin, cyclosarin, tabun, and VX were analyzed; peaks indicative of each simulant were identified. Vapor phase CWA simulants were adsorbed onto alumina, silica, Zeolite, activated carbon, and metal powders which were directly analyzed using SPAMS. The use of metal powders as adsorbent materials was especially useful in the analysis of triethyl phosphate (TEP), a VX stimulant, which was undetectable using SPAMS in the liquid phase. The capability of SPAMS to detect high explosives and CWA simulants using one set of operational conditions is established.

  14. A comparison of {sup 252}Cf and 14-MeV neutron excitation to identify chemical warfare agents by PGNAA

    Energy Technology Data Exchange (ETDEWEB)

    Caffrey, A.J.; Harlow, B.D.; Edwards, A.J.; Krebs, K.M.; Jones, J.L.; Yoon, W.; Zabriskie, J.M.; Dougan, A.D.

    2000-07-01

    Since 1992, Idaho National Engineering and Environmental Laboratory's portable isotopic neutron spectrometry (PINS) system has been widely used for the nondestructive assessment of munitions suspected to contain chemical warfare agents, such as the nerve agent sarin. PINS is a {sup 252}Cf-based prompt gamma-ray neutron activation analysis (PGNAA) system. The standard PINS system employs a partially moderated 5-{micro}g {sup 252}Cf source emitting 10{sup 7} n/s to excite the atomic nuclei inside the item under test. The chemical elements inside the item are revealed by their characteristic gamma-ray spectrum, measured by a high-resolution high-purity germanium gamma-ray spectrometer. The system computer then infers the fill compound or mixture from the elemental data extracted from the gamma-ray spectrum. Reliable PINS assessments can be completed in as little as 100 s for favorable cases such as white phosphorus smoke munitions, but normally, a 1000 to 3000 live-second counting interval is required. To improve PINS throughput when hundreds or more munitions must be assessed, they are evaluating the possible advantages of 14-MeV neutron excitation over their current radioisotopic source.

  15. Decomposition of 2-chloroethylethylsulfide on copper oxides to detoxify polymer-based spherical activated carbons from chemical warfare agents.

    Science.gov (United States)

    Fichtner, S; Hofmann, J; Möller, A; Schrage, C; Giebelhausen, J M; Böhringer, B; Gläser, R

    2013-11-15

    For the decomposition of chemical warfare agents, a hybrid material concept was applied. This consists of a copper oxide-containing phase as a component with reactive functionality supported on polymer-based spherical activated carbon (PBSAC) as a component with adsorptive functionality. A corresponding hybrid material was prepared by impregnation of PBSAC with copper(II)nitrate and subsequent calcination at 673K. The copper phase exists predominantly as copper(I)oxide which is homogeneously distributed over the PBSAC particles. The hybrid material containing 16 wt.% copper on PBSAC is capable of self-detoxifying the mustard gas surrogate 2-chloroethylethylsulfide (CEES) at room temperature. The decomposition is related to the breakthrough behavior of the reactant CEES, which displaces the reaction product ethylvinylsulfide (EVS). This leads to a combined breakthrough of CEES and EVS. The decomposition of CEES is shown to occur catalytically over the copper-containing PBSAC material. Thus, the hybrid material can even be considered to be self-cleaning. PMID:24140529

  16. Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity: Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.P.

    2003-07-24

    Percutaneous vapor toxicity guidelines are provided for assessment and selection of chemical protective ensembles (CPEs) to be used by civilian and military first responders operating in a chemical warfare agent vapor environment. The agents evaluated include the G-series and VX nerve agents, the vesicant sulfur mustard (agent HD) and, to a lesser extent, the vesicant Lewisite (agent L). The focus of this evaluation is percutaneous vapor permeation of CPEs and the resulting skin absorption, as inhalation and ocular exposures are assumed to be largely eliminated through use of SCBA and full-face protective masks. Selection of appropriately protective CPE designs and materials incorporates a variety of test parameters to ensure operability, practicality, and adequacy. One aspect of adequacy assessment should be based on systems tests, which focus on effective protection of the most vulnerable body regions (e.g., the groin area), as identified in this analysis. The toxicity range of agent-specific cumulative exposures (Cts) derived in this analysis can be used as decision guidelines for CPE acceptance, in conjunction with weighting consideration towards more susceptible body regions. This toxicity range is bounded by the percutaneous vapor estimated minimal effect (EME{sub pv}) Ct (as the lower end) and the 1% population threshold effect (ECt{sub 01}) estimate. Assumptions of exposure duration used in CPE certification should consider that each agent-specific percutaneous vapor cumulative exposure Ct for a given endpoint is a constant for exposure durations between 30 min and 2 hours.

  17. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi

    2009-06-01

    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  18. Synthetic biology and biosecurity: challenging the ‘myths’

    Directory of Open Access Journals (Sweden)

    Catherine eJefferson

    2014-08-01

    Full Text Available Synthetic biology, a field that aims to ‘make biology easier to engineer’, is routinely described as leading to an increase in the ‘dual use’ threat, i.e. the potential for the same piece of scientific research to be ‘used’ for peaceful purposes or ‘misused’ for warfare or terrorism. Fears have been expressed that the ‘de-skilling’ of biology, combined with online access to the genomic DNA sequences of pathogenic organisms and the reduction in price for DNA synthesis, will make biology increasingly accessible to people operating outside well-equipped professional research laboratories, including people with malevolent intentions. The emergence of DIY biology communities and of the student iGEM competition has come to epitomize this supposed trend towards greater ease of access and the associated potential threat from rogue actors. In this article, we identify 5 ‘myths’ that permeate discussions about synthetic biology and biosecurity, and argue that they embody misleading assumptions about both synthetic biology and bioterrorism. We demonstrate how these myths are challenged by more realistic understandings of the scientific research currently being conducted in both professional and DIY laboratories, and by an analysis of historical cases of bioterrorism. We show that the importance of tacit knowledge is commonly overlooked in the dominant narrative: the focus is on access to biological materials and digital information, rather than on human practices and institutional dimensions. As a result, public discourse on synthetic biology and biosecurity tends to portray speculative scenarios about the future as realities in the present or the near future, when this is not warranted. We suggest that these ‘myths’ play an important role in defining synthetic biology as a ‘promissory’ field of research and as an ‘emerging technology’ in need of governance.

  19. Quantum Biology

    CERN Document Server

    Sergi, Alessandro

    2009-01-01

    A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\\it living processes}, entailing amplification from the microscopic to the macroscopic scale, with increasing complexity in the passage from one scale to the other. Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces, is criticized. It is suggested that the correct interpretation of quantum dispersion forces (van der Waals, hydrogen bonding, and so on) as quantum coherence effects hints at the necessity of including long-ranged forces (or mechanisms for them) in condensed matter theories of biological processes. Some quantum effects in biology are reviewed and quantum mechanics is acknowledge...

  20. Handheld and mobile hyperspectral imaging sensors for wide-area standoff detection of explosives and chemical warfare agents

    Science.gov (United States)

    Gomer, Nathaniel R.; Gardner, Charles W.; Nelson, Matthew P.

    2016-05-01

    Hyperspectral imaging (HSI) is a valuable tool for the investigation and analysis of targets in complex background with a high degree of autonomy. HSI is beneficial for the detection of threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Two HSI techniques that have proven to be valuable are Raman and shortwave infrared (SWIR) HSI. Unfortunately, current generation HSI systems have numerous size, weight, and power (SWaP) limitations that make their potential integration onto a handheld or field portable platform difficult. The systems that are field-portable do so by sacrificing system performance, typically by providing an inefficient area search rate, requiring close proximity to the target for screening, and/or eliminating the potential to conduct real-time measurements. To address these shortcomings, ChemImage Sensor Systems (CISS) is developing a variety of wide-field hyperspectral imaging systems. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focused on sensor design and detection results.

  1. Biological Oceanography

    Science.gov (United States)

    Abbott, M. R.

    1984-01-01

    Within the framework of global biogeochemical cycles and ocean productivity, there are two areas that will be of particular interest to biological oceanography in the 1990s. The first is the mapping in space time of the biomass and productivity of phytoplankton in the world ocean. The second area is the coupling of biological and physical processes as it affects the distribution and growth rate of phytoplankton biomass. Certainly other areas will be of interest to biological oceanographers, but these two areas are amenable to observations from satellites. Temporal and spatial variability is a regular feature of marine ecosystems. The temporal and spatial variability of phytoplankton biomass and productivity which is ubiquitous at all time and space scales in the ocean must be characterized. Remote sensing from satellites addresses these problems with global observations of mesocale (2 to 20 days, 10 to 200 km) features over a long period of time.

  2. Chemical and biological weapons in the 'new wars'.

    Science.gov (United States)

    Ilchmann, Kai; Revill, James

    2014-09-01

    The strategic use of disease and poison in warfare has been subject to a longstanding and cross-cultural taboo that condemns the hostile exploitation of poisons and disease as the act of a pariah. In short, biological and chemical weapons are simply not fair game. The normative opprobrium is, however, not fixed, but context dependent and, as a social phenomenon, remains subject to erosion by social (or more specifically, antisocial) actors. The cross cultural understanding that fighting with poisons and disease is reprehensible, that they are taboo, is codified through a web of interconnected measures, principal amongst these are the 1925 Geneva Protocol; the Biological Weapons Convention; and the Chemical Weapons Convention. Whilst these treaties have weathered the storm of international events reasonably well, their continued health is premised on their being 'tended to' in the face of contextual changes, particularly facing changes in science and technology, as well as the changed nature and character of conflict. This article looks at the potential for normative erosion of the norm against chemical and biological weapons in the face of these contextual changes and the creeping legitimization of chemical and biological weapons. PMID:24132385

  3. Koncepcija partizanskoj vojny v Litve v 1920— 1930-e gody [The concept of guerrilla warfare in Lithuania in the 1920—1930s

    Directory of Open Access Journals (Sweden)

    Jokubauskas Vytautas

    2012-01-01

    Full Text Available This article analyses the military and tactical training of the members of the Lithuanian Riflemen’s Union for guerrilla warfare in the interwar period. Small nations, such as Lithuania and other Baltic states, being unable to build up military strength in order to ensure national security, were forced to seek for unconventional methods of warfare, including guerrilla strategies. The study places emphasis on the development of the guerrilla war concept in the Union periodicals. The author retraces a change in the intensity of the guerrilla warfare concept propagation amongst Lithuanian population and riflemen, in particular, through publications in the Trimitas — a periodical of the Lithuanian Riflemen’s Union. The author also identifies the narratives associated with the guerrilla matters employed for propaganda purposes in order to create an image of a guerrilla as a defender of the Homeland — Lithuania. Additionally, the structure and numbers of the Union are analysed through a comparison with similar organisations of the other «small nations» of the Baltic North-East. The author addresses the issue of military missions planned by the Lithuanian Army, as well as the way riflemen implemented them. Since the Union did not only offer military training, but was also engaged in the patriotic propaganda, the article focuses on the network of cultural institutions, homes of riflemen, orchestras, libraries, choirs, and athletic clubs used by the Union. The article sets out to establish whether the loss of Lithuanian sovereignty could have been possible without giving rise to a protracted guerrilla war.

  4. Formalization Modeling on VV&A Process for Warfare Simulation by UML%基于UML的作战仿真VV&A过程形式化建模

    Institute of Scientific and Technical Information of China (English)

    唐见兵; 查亚兵

    2013-01-01

    可信性是作战仿真的生命线,对作战仿真的全生命周期进行校核、验证与确认(Verification,Validation and Accreditation,VV&A)是确保其可信性的重要途径.建立合适的VV&A过程形式化模型是开展作战仿真VV&A过程研究的前提和基础.基于统一建模语言(Unified Modeling Language,UML)分别从用例、静态结构、动态行为及交互等方面对VV&A过程进行形式化建模,建立了作战仿真VV&A过程的用例、类图、活动图及顺序图模型,并给出相应的形式化定义.实践表明:作战仿真VV&A过程形式化建模可以使VV&A的描述规范化、标准化及形式化,便于不同领域人员的相互沟通与交流,以及VV&A工程化应用,促进了VV&A工作顺利开展.%The credibility is the lifeline of warfare simulation. To execute verification, validation and accreditation (VV&A) is an important approach to insure the credibility of warfare simulation system through out the life circle. It is the precondition and foundation to make the right formal model of VV&A process for warfare simulation. In this paper,the formal models of VV&A process is carried out,in which the details of use case,static construction,dynamic activities and interactions are modeled based on UML, and their formalization definitions are put forward. The practice shows that the formalization modeling on VV&A process for warfare simulation by UML can make it standardization, regularization and formalization,which can help the researchers in different domains to communicate with each other. The research of VV&A can be used in engineering,which help the job of VV&A is developed expediently.

  5. Mechanism of injury and microbiological flora of the geographical location are essential for the prognosis in soldiers with serious warfare injuries

    DEFF Research Database (Denmark)

    Wetterslev, Mik; Rose-Larsen, Katrine; Hansen-Schwartz, Jacob;

    2013-01-01

    INTRODUCTION: Denmark has been engaged in the Afghanistan war and as a result, Rigshospitalet has received a number of multi-traumatized Danish soldiers. Lesions sustained in armed conflict differ from their civilian counterparts and knowledge of the pathophysiology related to these types...... has been and remains a substantial part of warfare, and this review has showed us that the knowledge of the mechanism of injury is indeed essential, and that intelligence on the microbiological flora of the geographical location of the conflict is essential. FUNDING: not relevant. TRIAL REGISTRATION...

  6. Biology Notes.

    Science.gov (United States)

    School Science Review, 1981

    1981-01-01

    Outlines a variety of laboratory procedures, techniques, and materials including construction of a survey frame for field biology, a simple tidal system, isolation and applications of plant protoplasts, tropisms, teaching lung structure, and a key to statistical methods for biologists. (DS)

  7. (Biological dosimetry)

    Energy Technology Data Exchange (ETDEWEB)

    Preston, R.J.

    1990-12-17

    The traveler attended the 1st International Conference on Biological Dosimetry in Madrid, Spain. This conference was organized to provide information to a general audience of biologists, physicists, radiotherapists, industrial hygiene personnel and individuals from related fields on the current ability of cytogenetic analysis to provide estimates of radiation dose in cases of occupational or environmental exposure. There is a growing interest in Spain in biological dosimetry because of the increased use of radiation sources for medical and occupational uses, and with this the anticipated and actual increase in numbers of overexposure. The traveler delivered the introductory lecture on Biological Dosimetry: Mechanistic Concepts'' that was intended to provide a framework by which the more applied lectures could be interpreted in a mechanistic way. A second component of the trip was to provide advice with regard to several recent cases of overexposure that had been or were being assessed by the Radiopathology and Radiotherapy Department of the Hospital General Gregorio Maranon'' in Madrid. The traveler had provided information on several of these, and had analyzed cells from some exposed or purportedly exposed individuals. The members of the biological dosimetry group were referred to individuals at REACTS at Oak Ridge Associated Universities for advice on follow-up treatment.

  8. Biology Notes.

    Science.gov (United States)

    School Science Review, 1984

    1984-01-01

    Presents information on the teaching of nutrition (including new information relating to many current O-level syllabi) and part 16 of a reading list for A- and S-level biology. Also includes a note on using earthworms as a source of material for teaching meiosis. (JN)

  9. Mesoscopic biology

    Indian Academy of Sciences (India)

    G V Shivashankar

    2002-02-01

    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological systems. In recent years advances in technology have led to the study of some of the design principles of these machines; in particular at the level of an individual molecule. For example, the forces that operate in molecular interactions, the stochasticity involved in these interactions and their spatio-temporal dynamics are beginning to be explored. Understanding such design principles is opening new possibilities in mesoscopic physics with potential applications.

  10. Crusts: biological

    Science.gov (United States)

    Belnap, Jayne; Elias, Scott A.

    2013-01-01

    Biological soil crusts, a community of cyanobacteria, lichens, mosses, and fungi, are an essential part of dryland ecosystems. They are critical in the stabilization of soils, protecting them from wind and water erosion. Similarly, these soil surface communities also stabilized soils on early Earth, allowing vascular plants to establish. They contribute nitrogen and carbon to otherwise relatively infertile dryland soils, and have a strong influence on hydrologic cycles. Their presence can also influence vascular plant establishment and nutrition.

  11. Biological programming

    OpenAIRE

    Ramsden, Jeremy J.; Bándi, Gergely

    2010-01-01

    Biology offers a tremendous set of concepts that are potentially very powerfully usable for the software engineer, but they have been barely exploited hitherto. In this position paper we propose a fresh attempt to create the building blocks of a programming technology that could be as successful as life. A key guiding principle is to develop and make use of unambiguous definitions of the essential features of life.

  12. Marine biology

    International Nuclear Information System (INIS)

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index

  13. Marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Thurman, H.V.; Webber, H.H.

    1984-01-01

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index.

  14. Computational Investigations of Potential Energy Function Development for Metal--Organic Framework Simulations, Metal Carbenes, and Chemical Warfare Agents

    Science.gov (United States)

    Cioce, Christian R.

    sigma donates, and subsequent back-bonding occurs into a pi* antibonding orbital. This is a different type of interaction not seen in the three existing classes of metal-carbene complexes, namely Fischer, Schrock, and Grubbs. Finally, the virtual engineering of enhanced chemical warfare agent (CWA) detection systems is discussed. As part of a U.S. Department of Defense supported research project, in silico chemical modifications to a previously synthesized zinc-porphyrin, ZnCS1, were made to attempt to achieve preferential binding of the nerve agent sarin versus its simulant, DIMP (diisopropyl methylphosphonate). Upon modification, a combination of steric effects and induced hydrogen bonding allowed for the selective binding of sarin. The success of this work demonstrates the role that high performance computing can play in national security research, without the associated costs and high security required for experimentation.

  15. Establishment of Exposure to Organophosphorus Warfare Agents by Means of SPME-GSMS Analysis of Bodily Fluids

    International Nuclear Information System (INIS)

    Reliable chemical analytical procedures for revealing an exposure to toxic chemicals, identifying the active substance, and assessing the degree of exposure are necessary as a component of medical and forensic activities in cases of the possible use of highly toxic chemicals in war conflicts and terrorism acts, as well as emergency situations in chemical industry, specifically at chemical weapons storage and destruction facilities. According to Chemical Weapons Convention, Part XI, Appendix 4, e-17, 'samples of importance in the investigation of alleged use include biomedical samples from human or animal sources (blood, urine, excreta, tissue etc.)'. Urinary metabolites, O-alkyl esters of methylphosphic acid, offer one of the simplest means of confirming an exposure to organophosphorus warfare agents (OPWA). Urine, unlike blood or tissues, does not require invasive collection demanding in terms of sterility. Excretion with urine is the major route of elimination of OPWA from an organism. According to published data, 90% of OPWA metabolites are excreted within 48-72 h after intoxication. We developed an SPME-GCMS procedure for the determination of O-alkyl esters methylphosphonic acid in urine, with the following detection limits,: isopropyl and isobutyl esters 5 ng/ml and pinacolyl ester 1 ng/ml. The procedure involves derivatization of the target compounds directly on the microfiber. The total analysis time is 1-1.5 h. In animal experiments in vivo we could establish the exposure to OPWA at a half-LD50 level within no less than 48 h after intoxication. In principle, OPWA metabolites could be detected in urine within two weeks after intoxication but at higher doses. Retrospective analysis of urinary metabolites in cases of the exposure to low doses of OPWA requires lower detection limits (0.1-1 ng/ml). Optimal objects for the retrospective analysis of OPWA in an organism are long-lived blood protein adducts. We developed a procedure for revealing an exposure to

  16. Isolated iliotibial band rupture after corticosteroid injection as a cause of subjective instability and knee pain in a military special warfare trainee.

    Science.gov (United States)

    Pandit, Sandeep R; Solomon, Daniel J; Gross, Daniel J; Golijanin, Petar; Provencher, Matthew T

    2014-04-01

    Iliotibial band friction syndrome (ITBFS) of the knee is a common overuse injury in athletes, especially in runners. The syndrome occurs when the ITB, a lateral thickening of the fascia lata of the thigh moves repetitively over the lateral femoral condyle. A variety of nonoperative measures are used for ITBFS treatment, including stretching, core strengthening, and therapeutic injection. Isolated distal ITB rupture is a rare entity and has never yet to be reported in the orthopedic literature. We present a case of isolated ITB rupture as a cause of varus instability and knee pain in a Naval Special Warfare candidate diagnosed with ITBFS and previously treated with several local corticosteroid injections before ITB rupture. Because of continued knee pain and a sense of instability, along with an inability to return to his military special warfare duties, the ITB was surgically repaired. This case highlights the presentation and management of isolated distal ITB rupture and discusses some of the potential risk factors for rupture, including prior local corticosteroid injection.

  17. Demonstration of spread-on peel-off consumer products for sampling surfaces contaminated with pesticides and chemical warfare agent signatures.

    Science.gov (United States)

    Behringer, Deborah L; Smith, Deborah L; Katona, Vanessa R; Lewis, Alan T; Hernon-Kenny, Laura A; Crenshaw, Michael D

    2014-08-01

    A terrorist attack using toxic chemicals is an international concern. The utility of rubber cement and latex body paint as spray-on/spread-on peel-off collection media for signatures attributable to pesticides and chemical warfare agents from interior building and public transportation surfaces two weeks post-deposition is demonstrated. The efficacy of these media to sample escalator handrail, stainless steel, vinyl upholstery fabric, and wood flooring is demonstrated for two pesticides and eight chemicals related to chemical warfare agents. The chemicals tested are nicotine, parathion, atropine, diisopropyl methylphosphonate, dimethyl methylphosphonate, dipinacolyl methylphosphonate, ethyl methylphosphonic acid, isopropyl methylphosphonic acid, methylphosphonic acid, and thiodiglycol. Amounts of each chemical found are generally greatest when latex body paint is used. Analytes with low volatility and containing an alkaline nitrogen or a sulfur atom (e.g., nicotine and parathion) usually are recovered to a greater extent than the neutral phosphonate diesters and acidic phosphonic acids (e.g., dimethyl methylphosphonate and ethyl methylphosphonic acid). PMID:24835029

  18. The future development of naval ship in asymmetric warfare%非对称战争形态下舰船装备未来发展

    Institute of Scientific and Technical Information of China (English)

    吴亚雷

    2011-01-01

    结合当前国际政治经济形势,分析了我国海军未来面临的军事挑战特点,通过对舰船装备在非对称战争中发挥的核心作用进行研究,总结了未来取胜非对称战争的关键技术,分析了舰船装备未来发展趋势,对我国海军舰船装备未来发展提出了建议.%Based on the current international political and economic situation, the characteristics of future military challenges to the navy of our country are analyzed. By research of the main role of naval ship in asymmetric warfare, the key technologies to win the future asymmetric warfare are concluded, and the future development trends of naval ship are analyzed, and some suggestions to the naval ship development of our country are proposed.

  19. Application of Antibiotic on Sea Warfare Wound in Marine Environment%抗生素在海上环境下海战伤中的应用

    Institute of Scientific and Technical Information of China (English)

    张贞良; 贺顺龙; 谢培增; 汪先兵

    2011-01-01

    Objective To study an appropriate anti-inflammation treatment strategy on sea warfare wound in ma-rine environment Methods Animal model of combined sea warfare wound in marine environment was established in 40 mongrel dogs. The dogs were randomly divided into control group and treatment group. The control group accepted rou-tine cefodizime treatment, and the treatment group accepted cefodizime plus levofloxacin treatment The treatment on sea warfare wound was the same in both groups. The gross condition was observed and bacteriological strains in the wound were cultured and antibiotic sensitivity was tested at 2 and 4 days after the wound. Wound infection rate and mortality were observed at the sixth day. Results The infection rate within six days was 50% in the control group, and 10% in treatment group, and the mortality was 60% and 20% respectively. These rates were significantly lower in the treatment group than those in the control group (P<0. 01). The constituent ratio of vibrion in the treatment group was lower than that in the control group (P<0. 01). Conclusion There are many species of bacteria with wide distribution in South China Sea which mainly includes vibrionaceaes, staphylococcus and escherichia. These bacteria are the main causes leading to sea warfare wound infection. To deal with the sea warfare wound in marine environment, the early and complete debride-ment, and the early application of broadspectrum and anti-vibrion antibiotics should be emphasized.%目的 探讨抗生素在海上环境下海战伤中的有效应用.方法 选取40只成年杂种犬,制作海上环境下海水浸泡复合火器伤动物模型.随机将动物分成对照组和治疗组,每组20只犬.对照组采用头孢地嗪治疗,治疗组头孢地嗪加左氧氟沙星治疗.海战伤的其他处理方法相同.在伤后第2和第4天进行细菌培养与药敏试验,观察6天伤口感染率、死亡率.结果 伤后6天,对照组的伤口感染率为500,治疗组为10

  20. Biological Databases

    Directory of Open Access Journals (Sweden)

    Kaviena Baskaran

    2013-12-01

    Full Text Available Biology has entered a new era in distributing information based on database and this collection of database become primary in publishing information. This data publishing is done through Internet Gopher where information resources easy and affordable offered by powerful research tools. The more important thing now is the development of high quality and professionally operated electronic data publishing sites. To enhance the service and appropriate editorial and policies for electronic data publishing has been established and editors of article shoulder the responsibility.

  1. Biological biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Jorge-Herrero, E. [Servicio de Cirugia Experimental. Clinica Puerta de Hierro, Madrid (Spain)

    1997-05-01

    There are a number of situations in which substances of biological origin are employed as biomaterials. Most of them are macromolecules derived from isolated connective tissue or the connective tissue itself in membrane form, in both cases, the tissue can be used in its natural form or be chemically treated. In other cases, certain blood vessels can be chemically pretreated and used as vascular prostheses. Proteins such as albumin, collagen and fibrinogen are employed to coat vascular prostheses. Certain polysaccharides have also been tested for use in controlled drug release systems. Likewise, a number of tissues, such as dura mater, bovine pericardium, procine valves and human valves, are used in the preparation of cardiac prostheses. We also use veins from animals or humans in arterial replacement. In none of these cases are the tissues employed dissimilar to the native tissues as they have been chemically modified, becoming a new bio material with different physical and biochemical properties. In short, we find that natural products are being utilized as biomaterials and must be considered as such; thus, it is necessary to study both their chemicobiological and physicomechanical properties. In the present report, we review the current applications, problems and future prospects of some of these biological biomaterials. (Author) 84 refs.

  2. Preventing Space Warfare

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The international community should join forces to avoid possible conflicts in space Military competition and conflict in outer space can be divided into three stages:militarization,wea- ponization and the space battle- field. Space militarization has become a thing of the past.Now,many countries are re- searching more advanced space weaponry technology,which means space weapon- ization is becoming a growing reality.The process of space competition is astonishingly

  3. Chemical warfare in freshwater

    NARCIS (Netherlands)

    Mulderij, Gabi

    2006-01-01

    Aquatic macrophytes can excrete chemical substances into their enviroment and these compounds may inhibit the growth of phytoplankton. This process is defined as allelopathy: one organism has effects on another via the excretion of a (mixture of) chemical substance(s). With laboratory and field expe

  4. Creating biological nanomaterials using synthetic biology

    International Nuclear Information System (INIS)

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems. (review)

  5. Creating biological nanomaterials using synthetic biology

    Directory of Open Access Journals (Sweden)

    MaryJoe K Rice

    2014-01-01

    Full Text Available Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems.

  6. Toward improved software security training using a cyber warfare opposing force (CW OPFOR): the knowledge base design

    Science.gov (United States)

    Stytz, Martin R.; Banks, Sheila B.

    2005-03-01

    "Train the way you will fight" has been a guiding principle for military training and has served the warfighter well as evidenced by numerous successful operations over the last decade. This need for realistic training for all combatants has been recognized and proven by the warfighter and continues to guide military training. However, to date, this key training principle has not been applied fully in the arena of cyberwarfare due to the lack of realistic, cost effective, reasonable, and formidable cyberwarfare opponents. Recent technological advances, improvements in the capability of computer-generated forces (CGFs) to emulate human behavior, and current results in research in information assurance and software protection, coupled with increasing dependence upon information superiority, indicate that the cyberbattlespace will be a key aspect of future conflict and that it is time to address the cyberwarfare training shortfall. To address the need for a cyberwarfare training and defensive testing capability, we propose research and development to yield a prototype computerized, semi-autonomous (SAF) red team capability. We term this capability the Cyber Warfare Opposing Force (CW OPFOR). There are several technologies that are now mature enough to enable, for the first time, the development of this powerful, effective, high fidelity CW OPFOR. These include improved knowledge about cyberwarfare attack and defense, improved techniques for assembling CGFs, improved techniques for capturing and expressing knowledge, software technologies that permit effective rapid prototyping to be effectively used on large projects, and the capability for effective hybrid reasoning systems. Our development approach for the CW OPFOR lays out several phases in order to address these requirements in an orderly manner and to enable us to test the capabilities of the CW OPFOR and exploit them as they are developed. We have completed the first phase of the research project, which

  7. Groundwater geochemical and selected volatile organic compound data, Operable Unit 1, Naval Undersea Warfare Center, Division Keyport, Washington, June 2011

    Science.gov (United States)

    Huffman, Raegan L.; Frans, L.M.

    2012-01-01

    Previous investigations indicate that concentrations of chlorinated volatile organic compounds are substantial in groundwater beneath the 9-acre former landfill at Operable Unit 1, Naval Undersea Warfare Center, Division Keyport, Washington. Phytoremediation combined with ongoing natural attenuation processes was the preferred remedy selected by the U.S. Navy, as specified in the Record of Decision for the site. The U.S. Navy planted two hybrid poplar plantations on the landfill in spring 1999 to remove and to control the migration of chlorinated volatile organic compounds in shallow groundwater. The U.S. Geological Survey has continued to monitor groundwater geochemistry to ensure that conditions remain favorable for contaminant biodegradation as specified in the Record of Decision. This report presents groundwater geochemical and selected volatile organic compound data collected at Operable Unit 1 by the U.S. Geological Survey during June 20-22, 2011, in support of long-term monitoring for natural attenuation. In 2011, groundwater samples were collected from 13 wells and 9 piezometers. Samples from all wells and piezometers were analyzed for redox sensitive constituents and dissolved gases, and samples from 5 of 13 wells and all piezometers also were analyzed for chlorinated volatile organic compounds. Concentrations of redox sensitive constituents measured in 2011 were consistent with previous years, with dissolved oxygen concentrations all at 0.4 milligram per liter or less; little to no detectable nitrate; abundant dissolved manganese, iron, and methane; and commonly detected sulfide. The reductive declorination byproducts - methane, ethane, and ethene - were either not detected in samples collected from the upgradient wells in the landfill and the upper aquifer beneath the northern phytoremediation plantation or were detected at concentrations less than those measured in 2010. Chlorinated volatile organic compound concentrations in 2011 at most piezometers

  8. 基于Lanchester方程的作战混合动态系统最优变招控制%Optimal variable tactic control of warfare hybrid dynamic system based on Lanchester equation

    Institute of Scientific and Technical Information of China (English)

    陈向勇; 井元伟; 李春吉

    2012-01-01

    根据作战混合动态过程特性,提出了一种基于Lanchcstcr方程的作战混合动态系统模型.该模型可较好的描述离散事件驱动的对阵招法和连续作战实力变化之间的相互作用.在合理战术假设的基础上,讨论了作战混合动态系统最优变招控制问题.首先,利用微分对策理论得到了作战招法存在的必要条件.进而对作战变招过程进行分析,并提出了一种最优变招控制策略的求解方法.最后,应用算例验证了所构建作战混合系统模型和所设计最优变招策略的可行性.%According to the characteristics of warfare hybrid dynamic process, we develop a warfare hybrid dynamic system model by using Lanchester equation, which better describes the interaction between discrete event-driven tactics and the strength changes in continuous fighting. We also investigate the optimal variable tactic control for the warfare hybrid dynamic system under certain reasonable assumptions. In the existing condition of the warfare tactics based on the differential game theory, we analyze the process of variable tactics and propose the solving method for determining the optimal strategy for variable tactic control. A numerical example shows the feasibility of the warfare hybrid system and the effectiveness of the developed optimal variable tactics.

  9. Structural Biology Fact Sheet

    Science.gov (United States)

    ... Home > Science Education > Structural Biology Fact Sheet Structural Biology Fact Sheet Tagline (Optional) Middle/Main Content Area What is structural biology? Structural biology is a field of science focused ...

  10. Simulating Biological and Non-Biological Motion

    Science.gov (United States)

    Bruzzo, Angela; Gesierich, Benno; Wohlschlager, Andreas

    2008-01-01

    It is widely accepted that the brain processes biological and non-biological movements in distinct neural circuits. Biological motion, in contrast to non-biological motion, refers to active movements of living beings. Aim of our experiment was to investigate the mechanisms underlying mental simulation of these two movement types. Subjects had to…

  11. Biological Literacy in a College Biology Classroom.

    Science.gov (United States)

    Demastes, Sherry; Wandersee, James H.

    1992-01-01

    Examines the proposed definition of biological literacy as the understanding of a small number of pervasive biological principles appropriate to making informed personal and societal decisions. Utilizes the content of a major daily newspaper to adjust biology instruction to focus on this notion of biological literacy. Discusses benefits and…

  12. A Brief Introduction to Chinese Biological Biological

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Chinese Biological Abstracts sponsored by the Library, the Shanghai Institutes for Biological Sciences, the Biological Documentation and Information Network, all of the Chinese Academy of Sciences, commenced publication in 1987 and was initiated to provide access to the Chinese information in the field of biology.

  13. Distribution-mode Logistical Support in Modern Warfare%现代战争条件下的配送式后勤保障

    Institute of Scientific and Technical Information of China (English)

    吴兆东; 朱江浩

    2016-01-01

    The distribution-mode logistical support is the product of the warfare in the information era and has become a basic form of the modern logistical practices. In this paper, in connection with the characteristics of military distribution and transportation, we analyzed the logistical support mode of the U.S. army in the war in Iraq and then proposed some thoughts on building the distribution-mode logistical support system by the Chinese army.%配送式后勤保障是信息化条件下的战争产物,已成为现代后勤保障的基本形式.结合军事物流配送的特点,分析了伊拉克战争中美军这种后勤保障模式的特点,提出关于我军配送式后勤保障建设的思考.

  14. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures.

    Science.gov (United States)

    Dumlao, Morphy C; Jeffress, Laura E; Gooding, J Justin; Donald, William A

    2016-06-21

    Solid-phase microextraction (SPME) is directly integrated with low temperature plasma ionisation mass spectrometry to rapidly detect organophosphate chemical warfare agent simulants and their hydrolysis products in chemical mixtures, including urine. In this sampling and ionization method, the fibre serves: (i) to extract molecules from their native environment, and (ii) as the ionization electrode that is used to desorb and ionize molecules directly from the SPME surface. By use of a custom fabricated SPME fibre consisting of a stainless steel needle coated with a Linde Type A (LTA) zeolitic microporous material and low temperature plasma mass spectrometry, protonated dimethyl methylphosphonate (DMMP), diethyl ethylphosphonate (DEEP) and pinacolyl methylphosphonic acid (PinMPA) can be detected at less than 100 ppb directly in water and urine. Organophosphates were not readily detected by this approach using an uncoated needle in negative control experiments. The use of the LTA coating significantly outperformed the use of a high alumina Zeolite Socony Mobil-5 (ZSM-5) coating of comparable thickness that is significantly less polar than LTA. By conditioning the LTA probe by immersion in an aqueous CuSO4 solution, the ion abundance for protonated DMMP increased by more than 300% compared to that obtained without any conditioning. Sample recovery values were between 96 and 100% for each analyte. The detection of chemical warfare agent analogues and hydrolysis products required less than 2 min per sample. A key advantage of this sampling and ionization method is that analyte ions can be directly and rapidly sampled from chemical mixtures, such as urine and seawater, without sample preparation or chromatography for sensitive detection by mass spectrometry. This ion source should prove beneficial for portable mass spectrometry applications because relatively low detection limits can be obtained without the use of compressed gases, fluid pumps, and lasers. Moreover, the

  15. Bioaccumulation of chemical warfare agents, energetic materials, and metals in deep-sea shrimp from discarded military munitions sites off Pearl Harbor

    Science.gov (United States)

    Koide, Shelby; Silva, Jeff A. K.; Dupra, Vilma; Edwards, Margo

    2016-06-01

    The bioaccumulation of munitions-related chemicals at former military deep-water disposal sites is poorly understood. This paper presents the results of human-food-item biota sampling to assess the potential for bioaccumulation of chemical warfare agents, energetic materials, arsenic, and additional munitions-related metals in deep-sea shrimp tissue samples collected during the Hawai'i Undersea Military Munitions Assessment (HUMMA) project to date. The HUMMA investigation area is located within a former munitions sea-disposal site located south of Pearl Harbor on the island of O'ahu, Hawai'i, designated site Hawaii-05 (HI-05) by the United States Department of Defense. Indigenous deep-sea shrimp (Heterocarpus ensifer) were caught adjacent to discarded military munitions (DMM) and at control sites where munitions were absent. Tissue analysis results showed that chemical warfare agents and their degradation products were not present within the edible portions of these samples at detectable concentrations, and energetic materials and their degradation products were detected in only a few samples at concentrations below the laboratory reporting limits. Likewise, arsenic, copper, and lead concentrations were below the United States Food and Drug Administration's permitted concentrations of metals in marine biota tissue (if defined), and their presence within these samples could not be attributed to the presence of DMM within the study area based on a comparative analysis of munitions-adjacent and control samples collected. Based on this current dataset, it can be concluded that DMM existing within the HUMMA study area is not contributing to the bioaccumulation of munitions-related chemicals for the biota species investigated to date.

  16. Ion mobility spectrometric analysis of vaporous chemical warfare agents by the instrument with corona discharge ionization ammonia dopant ambient temperature operation.

    Science.gov (United States)

    Satoh, Takafumi; Kishi, Shintaro; Nagashima, Hisayuki; Tachikawa, Masumi; Kanamori-Kataoka, Mieko; Nakagawa, Takao; Kitagawa, Nobuyoshi; Tokita, Kenichi; Yamamoto, Soichiro; Seto, Yasuo

    2015-03-20

    The ion mobility behavior of nineteen chemical warfare agents (7 nerve gases, 5 blister agents, 2 lachrymators, 2 blood agents, 3 choking agents) and related compounds including simulants (8 agents) and organic solvents (39) was comparably investigated by the ion mobility spectrometry instrument utilizing weak electric field linear drift tube with corona discharge ionization, ammonia doping, purified inner air drift flow circulation operated at ambient temperature and pressure. Three alkyl methylphosphonofluoridates, tabun, and four organophosphorus simulants gave the intense characteristic positive monomer-derived ion peaks and small dimer-derived ion peaks, and the later ion peaks were increased with the vapor concentrations. VX, RVX and tabun gave both characteristic positive monomer-derived ions and degradation product ions. Nitrogen mustards gave the intense characteristic positive ion peaks, and in addition distinctive negative ion peak appeared from HN3. Mustard gas, lewisite 1, o-chlorobenzylidenemalononitrile and 2-mercaptoethanol gave the characteristic negative ion peaks. Methylphosphonyl difluoride, 2-chloroacetophenone and 1,4-thioxane gave the characteristic ion peaks both in the positive and negative ion mode. 2-Chloroethylethylsulfide and allylisothiocyanate gave weak ion peaks. The marker ion peaks derived from two blood agents and three choking agents were very close to the reactant ion peak in negative ion mode and the respective reduced ion mobility was fluctuated. The reduced ion mobility of the CWA monomer-derived peaks were positively correlated with molecular masses among structurally similar agents such as G-type nerve gases and organophosphorus simulants; V-type nerve gases and nitrogen mustards. The slope values of the calibration plots of the peak heights of the characteristic marker ions versus the vapor concentrations are related to the detection sensitivity, and within chemical warfare agents examined the slope values for sarin, soman

  17. Creating biological nanomaterials using synthetic biology

    OpenAIRE

    MaryJoe K Rice; Ruder, Warren C.

    2014-01-01

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic bi...

  18. Cell biology perspectives in phage biology.

    Science.gov (United States)

    Ansaldi, Mireille

    2012-01-01

    Cellular biology has long been restricted to large cellular organisms. However, as the resolution of microscopic methods increased, it became possible to study smaller cells, in particular bacterial cells. Bacteriophage biology is one aspect of bacterial cell biology that has recently gained insight from cell biology. Despite their small size, bacteriophages could be successfully labeled and their cycle studied in the host cells. This review aims to put together, although non-extensively, several cell biology studies that recently pushed the elucidation of key mechanisms in phage biology, such as the lysis-lysogeny decision in temperate phages or genome replication and transcription, one step further.

  19. Truth about the Consequence of Bacteriological Warfare of Disseminating Plague Bacteria%散布鼠疫菌(PX)细菌战“战果”之真相

    Institute of Scientific and Technical Information of China (English)

    莇昭三[日](著); 韩慧光(译)

    2015-01-01

    日本军在中国实施细菌战的事实,随着中日学者的研究逐渐被揭示,在研究中所用材料大部分都是加害者(当事人)和受害者的口述史,缺乏日本军当时实施细菌战后对被害地的全面详细的疫学调查。731部队细菌战研究人员金子顺一论文《鼠疫效果略算法》,揭示了1940年农安、新京鼠疫流行事件是731部队实施的细菌战的事实。《陆军军医学校防疫研究报告第2部》中的高桥正彦论文中关于农安、新京鼠疫流行事件的论文,是731部队细菌战后对被害地进行的疫学调查。达格威文件Q报告中的部分数据来自“农安细菌战”受害者的病理解剖,其中不仅有中国人,也有日本人。%Facts about bacteriological warfare conducted by Japanese Army in China have been gradually re-vealed by related Chinese and Japanese researchers. However, the majority of materials used in the research are oral history orally accounted by offenders and victims, hence the lack of epidemic prevention surveys on the inflicted areas of bacteriological warfare by Japanese army. The thesis paper by Jun-Ichi Kaneko (bacterial warfare researcher of U-nit 731) namedBubonicPlagueAlgorithmunveiled the fact that plague epidemics which struck Nong’an and Changchun were caused by the Unit 731’s bacteriological warfare. Takahashi’s thesis paper inArmyMedicalCol-legeEpidemicPreventionResearchReport(VolumeⅡ)on plague epidemics that hit Nong’an and Changchun is in connection with the epidemic prevention surveys on the inflicted areas of bacteriological warfare carried out by the U-nit 731. Some data of the Report of“Q”from Dugway Proving Ground Documents came from pathological anatomy of victims of Nong’an bacteriological warfare, some of whom were Chinese and Japanese.

  20. Biological effects of radiation

    International Nuclear Information System (INIS)

    This fourth chapter presents: cell structure and metabolism; radiation interaction with biological tissues; steps of the production of biological effect of radiation; radiosensitivity of tissues; classification of biological effects; reversibility, transmissivity and influence factors; pre-natal biological effects; biological effects in therapy and syndrome of acute irradiation

  1. Intelligent Evaluation for Aerial Warfare Efficiency of Fighter-plane Based on Rough Set and Support Vector Machine%粗集支持向量机的战斗机空战效能智能评估

    Institute of Scientific and Technical Information of China (English)

    龚胜科; 徐浩军; 林敏

    2012-01-01

    根据现代空战特点,选取了战斗机的空战效能评估指标集,并采用粗糙集理论对指标体系进行约简,提取对空战效能影响起关键作用的特征参数,消除冗余信息,减少了支持向量的维效.支持向量机( SVM)具有结构简单、全局最优、泛化能力强的优点.根据所提取的特征参数,文中提出采用回归型支持向量机(SVR)建立空战效能智能评估模型,并通过实例与指数法和BP神经网络法计算结果进行了比较,验证了该模型的可行性和有效性.%According to the characteristic of modern aerial warfare. the index set of aerial warfare efficiency evaluation is selected in this paper. Reduction is performed on index systems based on rough set theory to extract characteristic parameters which affect aerial warfare efficiency crucially, which is to remove redundant information and reduce the dimension of support vector. Support vector machine (SVM) has the advantages of simple structure, global optimum and high generalization ability. With the characteristic parameters, intelligent evaluation model for aerial warfare efficiency of fighter-plane is establish by using Support Vector Regression (SVR), and we compare the SVR with index method and BP network method by a case study, which verified the feasibility and validity of the model.

  2. The Challenges of Cyber Warfare to International Law:From Perspective of The Tallinn Manual on The International Law Applicable to Cyber Warfare%从《塔林手册》看网络战争对国际法的挑战

    Institute of Scientific and Technical Information of China (English)

    张天舒

    2014-01-01

    Tallinn Manual on The International Law Applicable to Cyber Warfare results from an expert -driven process designed to produce a non -binding document applying existing law to cyber warfare .It encompasses both jus ad bellum and jus in bello , as well as related bodies of general international law , such as the law of State re-sponsibility etc .It is believed that how the Manual elaborates on current international law applicable to cyber war -fare reflects the current development of international law about cyber warfare .However , it is also arguable about the methodology used to ascertain rules and the composition of the International Group of Experts .Additionally , the Manual contains several flaws in the formulation of the rules and the relevant comments .Given to all these reasons , how much the Manual could affect states and international law still remains uncertain and need to be proven in the future.%《适用于网络战争的国际法塔林手册》(以下简称“《塔林手册》”)分别讨论了一般国际法和国际人道法如何适用于网络空间和网络战争中的重要问题。《塔林手册》对适用于网络战争的国际法进行的系统归纳和总结,将会影响国际社会对网络战争的认识。但是《塔林手册》在编纂方式和国际专家组的人员构成方面存在先天不足,而且其中的若干具体规则也与现今国际法有些许出入。《塔林手册》究竟能在什么程度上影响国家实践和国际法的发展,还有待检验。

  3. 基于FLAMES的电子战仿真模型的组合建模%Combined Modeling of Electronic Warfare Simulation Model Based on FLAMES

    Institute of Scientific and Technical Information of China (English)

    吴志建; 方胜良; 朱林

    2012-01-01

    随着军用仿真技术的不断发展,使得多领域的模型集成变得更加困难,模型组合和可重用性不足问题显得十分突出。阐述了组合建模和柔性行为分析与建模评估系统(FLAMES)建模原理,针对FLAMES柔性仿真框架下建模灵活性的特点,并结合关联假设的组合建模理论,提出了基于FLAMES的电子战仿真模型的组合仿真概念框架和建模方法,以某型电子战飞机为例,通过仿真实验分析仿真数据。结果表明,该方法能够有效对模型进行组合建模,能为基于FLAMES柔性仿真框架的模型组件开发及其组合建模提供一定的依据。%Along with the continuous development of military simulation technologies,the integration among multi-domain models becomes more and more difficultly,the problems such as the insufficient model combination and reusability look very outstandingly.This paper expatiates the theories of combined modeling and flexible analysis and modeling effectiveness system(FLAMES) modeling,aiming at the characteristic of modeling flexibility in FLAMES flexible simulation framework,and combining with the combined modeling theory of related hypothesis,brings forward the combined simulation concept framework and modeling method of electronic warfare simulation model based on FLAMES,takes a certain electronic warfare airplane as an example,analyzes the simulation data through simulation experiment.Results show that this method can effectively perform the combined modeling to the models,which can provide definite basis for the model component development and combined modeling based on FLAMES flexible simulation framework.

  4. Development of the HS-SPME-GC-MS/MS method for analysis of chemical warfare agent and their degradation products in environmental samples.

    Science.gov (United States)

    Nawała, Jakub; Czupryński, Krzysztof; Popiel, Stanisław; Dziedzic, Daniel; Bełdowski, Jacek

    2016-08-24

    After World War II approximately 50,000 tons of chemical weapons were dumped in the Baltic Sea by the Soviet Union under the provisions of the Potsdam Conference on Disarmament. These dumped chemical warfare agents still possess a major threat to the marine environment and to human life. Therefore, continue monitoring of these munitions is essential. In this work, we present the application of new solid phase microextraction fibers in analysis of chemical warfare agents and their degradation products. It can be concluded that the best fiber for analysis of sulfur mustard and its degradation products is butyl acrylate (BA), whereas for analysis of organoarsenic compounds and chloroacetophenone, the best fiber is a co-polymer of methyl acrylate and methyl methacrylate (MA/MMA). In order to achieve the lowest LOD and LOQ the samples should be divided into two subsamples. One of them should be analyzed using a BA fiber, and the second one using a MA/MMA fiber. When the fast analysis is required, the microextraction should be performed by use of a butyl acrylate fiber because the extraction efficiency of organoarsenic compounds for this fiber is acceptable. Next, we have elaborated of the HS-SPME-GC-MS/MS method for analysis of CWA degradation products in environmental samples using laboratory obtained fibers The analytical method for analysis of organosulfur and organoarsenic compounds was optimized and validated. The LOD's for all target chemicals were between 0.03 and 0.65 ppb. Then, the analytical method developed by us, was used for the analysis of sediment and pore water samples from the Baltic Sea. During these studies, 80 samples were analyzed. It was found that 25 sediments and 5 pore water samples contained CWA degradation products such as 1,4-dithiane, 1,4-oxathiane or triphenylarsine, the latter being a component of arsine oil. The obtained data is evidence that the CWAs present in the Baltic Sea have leaked into the general marine environment. PMID

  5. Development of the HS-SPME-GC-MS/MS method for analysis of chemical warfare agent and their degradation products in environmental samples.

    Science.gov (United States)

    Nawała, Jakub; Czupryński, Krzysztof; Popiel, Stanisław; Dziedzic, Daniel; Bełdowski, Jacek

    2016-08-24

    After World War II approximately 50,000 tons of chemical weapons were dumped in the Baltic Sea by the Soviet Union under the provisions of the Potsdam Conference on Disarmament. These dumped chemical warfare agents still possess a major threat to the marine environment and to human life. Therefore, continue monitoring of these munitions is essential. In this work, we present the application of new solid phase microextraction fibers in analysis of chemical warfare agents and their degradation products. It can be concluded that the best fiber for analysis of sulfur mustard and its degradation products is butyl acrylate (BA), whereas for analysis of organoarsenic compounds and chloroacetophenone, the best fiber is a co-polymer of methyl acrylate and methyl methacrylate (MA/MMA). In order to achieve the lowest LOD and LOQ the samples should be divided into two subsamples. One of them should be analyzed using a BA fiber, and the second one using a MA/MMA fiber. When the fast analysis is required, the microextraction should be performed by use of a butyl acrylate fiber because the extraction efficiency of organoarsenic compounds for this fiber is acceptable. Next, we have elaborated of the HS-SPME-GC-MS/MS method for analysis of CWA degradation products in environmental samples using laboratory obtained fibers The analytical method for analysis of organosulfur and organoarsenic compounds was optimized and validated. The LOD's for all target chemicals were between 0.03 and 0.65 ppb. Then, the analytical method developed by us, was used for the analysis of sediment and pore water samples from the Baltic Sea. During these studies, 80 samples were analyzed. It was found that 25 sediments and 5 pore water samples contained CWA degradation products such as 1,4-dithiane, 1,4-oxathiane or triphenylarsine, the latter being a component of arsine oil. The obtained data is evidence that the CWAs present in the Baltic Sea have leaked into the general marine environment.

  6. Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods.

    Science.gov (United States)

    Flood, Ann Barry; Ali, Arif N; Boyle, Holly K; Du, Gaixin; Satinsky, Victoria A; Swarts, Steven G; Williams, Benjamin B; Demidenko, Eugene; Schreiber, Wilson; Swartz, Harold M

    2016-08-01

    The aim of this paper is to delineate characteristics of biodosimetry most suitable for assessing individuals who have potentially been exposed to significant radiation from a nuclear device explosion when the primary population targeted by the explosion and needing rapid assessment for triage is civilians vs. deployed military personnel. The authors first carry out a systematic analysis of the requirements for biodosimetry to meet the military's needs to assess deployed troops in a warfare situation, which include accomplishing the military mission. Then the military's special capabilities to respond and carry out biodosimetry for deployed troops in warfare are compared and contrasted systematically, in contrast to those available to respond and conduct biodosimetry for civilians who have been targeted by terrorists, for example. Then the effectiveness of different biodosimetry methods to address military vs. civilian needs and capabilities in these scenarios was compared and, using five representative types of biodosimetry with sufficient published data to be useful for the simulations, the number of individuals are estimated who could be assessed by military vs. civilian responders within the timeframe needed for triage decisions. Analyses based on these scenarios indicate that, in comparison to responses for a civilian population, a wartime military response for deployed troops has both more complex requirements for and greater capabilities to use different types of biodosimetry to evaluate radiation exposure in a very short timeframe after the exposure occurs. Greater complexity for the deployed military is based on factors such as a greater likelihood of partial or whole body exposure, conditions that include exposure to neutrons, and a greater likelihood of combined injury. These simulations showed, for both the military and civilian response, that a very fast rate of initiating the processing (24,000 d) is needed to have at least some methods capable of

  7. Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods.

    Science.gov (United States)

    Flood, Ann Barry; Ali, Arif N; Boyle, Holly K; Du, Gaixin; Satinsky, Victoria A; Swarts, Steven G; Williams, Benjamin B; Demidenko, Eugene; Schreiber, Wilson; Swartz, Harold M

    2016-08-01

    The aim of this paper is to delineate characteristics of biodosimetry most suitable for assessing individuals who have potentially been exposed to significant radiation from a nuclear device explosion when the primary population targeted by the explosion and needing rapid assessment for triage is civilians vs. deployed military personnel. The authors first carry out a systematic analysis of the requirements for biodosimetry to meet the military's needs to assess deployed troops in a warfare situation, which include accomplishing the military mission. Then the military's special capabilities to respond and carry out biodosimetry for deployed troops in warfare are compared and contrasted systematically, in contrast to those available to respond and conduct biodosimetry for civilians who have been targeted by terrorists, for example. Then the effectiveness of different biodosimetry methods to address military vs. civilian needs and capabilities in these scenarios was compared and, using five representative types of biodosimetry with sufficient published data to be useful for the simulations, the number of individuals are estimated who could be assessed by military vs. civilian responders within the timeframe needed for triage decisions. Analyses based on these scenarios indicate that, in comparison to responses for a civilian population, a wartime military response for deployed troops has both more complex requirements for and greater capabilities to use different types of biodosimetry to evaluate radiation exposure in a very short timeframe after the exposure occurs. Greater complexity for the deployed military is based on factors such as a greater likelihood of partial or whole body exposure, conditions that include exposure to neutrons, and a greater likelihood of combined injury. These simulations showed, for both the military and civilian response, that a very fast rate of initiating the processing (24,000 d) is needed to have at least some methods capable of

  8. Synthetic biology: insights into biological computation.

    Science.gov (United States)

    Manzoni, Romilde; Urrios, Arturo; Velazquez-Garcia, Silvia; de Nadal, Eulàlia; Posas, Francesc

    2016-04-18

    Organisms have evolved a broad array of complex signaling mechanisms that allow them to survive in a wide range of environmental conditions. They are able to sense external inputs and produce an output response by computing the information. Synthetic biology attempts to rationally engineer biological systems in order to perform desired functions. Our increasing understanding of biological systems guides this rational design, while the huge background in electronics for building circuits defines the methodology. In this context, biocomputation is the branch of synthetic biology aimed at implementing artificial computational devices using engineered biological motifs as building blocks. Biocomputational devices are defined as biological systems that are able to integrate inputs and return outputs following pre-determined rules. Over the last decade the number of available synthetic engineered devices has increased exponentially; simple and complex circuits have been built in bacteria, yeast and mammalian cells. These devices can manage and store information, take decisions based on past and present inputs, and even convert a transient signal into a sustained response. The field is experiencing a fast growth and every day it is easier to implement more complex biological functions. This is mainly due to advances in in vitro DNA synthesis, new genome editing tools, novel molecular cloning techniques, continuously growing part libraries as well as other technological advances. This allows that digital computation can now be engineered and implemented in biological systems. Simple logic gates can be implemented and connected to perform novel desired functions or to better understand and redesign biological processes. Synthetic biological digital circuits could lead to new therapeutic approaches, as well as new and efficient ways to produce complex molecules such as antibiotics, bioplastics or biofuels. Biological computation not only provides possible biomedical and

  9. Synthetic biology: insights into biological computation.

    Science.gov (United States)

    Manzoni, Romilde; Urrios, Arturo; Velazquez-Garcia, Silvia; de Nadal, Eulàlia; Posas, Francesc

    2016-04-18

    Organisms have evolved a broad array of complex signaling mechanisms that allow them to survive in a wide range of environmental conditions. They are able to sense external inputs and produce an output response by computing the information. Synthetic biology attempts to rationally engineer biological systems in order to perform desired functions. Our increasing understanding of biological systems guides this rational design, while the huge background in electronics for building circuits defines the methodology. In this context, biocomputation is the branch of synthetic biology aimed at implementing artificial computational devices using engineered biological motifs as building blocks. Biocomputational devices are defined as biological systems that are able to integrate inputs and return outputs following pre-determined rules. Over the last decade the number of available synthetic engineered devices has increased exponentially; simple and complex circuits have been built in bacteria, yeast and mammalian cells. These devices can manage and store information, take decisions based on past and present inputs, and even convert a transient signal into a sustained response. The field is experiencing a fast growth and every day it is easier to implement more complex biological functions. This is mainly due to advances in in vitro DNA synthesis, new genome editing tools, novel molecular cloning techniques, continuously growing part libraries as well as other technological advances. This allows that digital computation can now be engineered and implemented in biological systems. Simple logic gates can be implemented and connected to perform novel desired functions or to better understand and redesign biological processes. Synthetic biological digital circuits could lead to new therapeutic approaches, as well as new and efficient ways to produce complex molecules such as antibiotics, bioplastics or biofuels. Biological computation not only provides possible biomedical and

  10. Translational environmental biology: cell biology informing conservation.

    Science.gov (United States)

    Traylor-Knowles, Nikki; Palumbi, Stephen R

    2014-05-01

    Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate immunity and acclimatization have prompted new developments in conservation. Similar to biomedicine, we urge that future efforts should focus on better frameworks for biomarker development to protect coral reefs.

  11. Research on Command Information System Invulnerability in Network-Centric Warfare%网络中心战指挥信息系统抗毁性研究

    Institute of Scientific and Technical Information of China (English)

    王欣; 姚佩阳; 周翔翔; 张杰勇; 万路军

    2011-01-01

    An evaluation method of command information system invulnerability based on service capability in Network-Centric Warfare(NCW)is proposed. The service mechanism of command information system in NCW is analyzed, and the concept of service functional chain is given for system service capability evaluation. The evaluations of system invulnerability and node significance are derived from thc influences of both network topology and service relations between nodes. An instance is designed, and the method's feasibility is verified by the simulation results.%分析网络中心战下指挥信息系统为作战服务的机理,给出服务功能链的概念,用服务能力作为衡量系统服务能力的基准.兼顾网络拓扑结构和节点服务关系两方面因素对系统抗毁性的影响,设计基于服务能力的网络中心战指挥信息系统抗毁性评价方法,并给出节点重要度的综合计算方法.以指挥信息系统网络为实例进行仿真,结果表明该方法的可行性.

  12. Strategic Political Work and Strategic Psychological Warfare%战时政治工作与战略心理作战

    Institute of Scientific and Technical Information of China (English)

    军事科学院《战略学》课题组

    2005-01-01

    Wartime political work refers to the ideological and organizational work undertaken by the armed forces while performing combat tasks. Strategic psychological warfare means the strategic confrontational activities in which psychological offensives are launched according to the principles of psychology in order to undermine the morale of both the enemy troops and its civilians or to eliminate the consequences of the enemy's deceptive propaganda, and it is a component part of wartime political work. Conducting thoroughgoing wartime political work is a unique political advantage of the PLA and an important guarantee for preserving the true political qualities of the people's army, arousing the fighting will, increasing the cohesion of our soldiers' morale, keeping internal unity against the enemy,and winning the war.%战时政治工作是军队履行作战任务期间进行的思想工作和组织工作,是发挥我军独特的政治优势的重要途径.战略心理作战是运用心理学原理,开展心理攻势,从精神上瓦解敌方军民斗志或消除敌欺骗宣传后果而进行的战略对抗活动,在战时它是战时政治工作的组成部分.

  13. Graphene oxide as sensitive layer in Love-wave surface acoustic wave sensors for the detection of chemical warfare agent simulants.

    Science.gov (United States)

    Sayago, Isabel; Matatagui, Daniel; Fernández, María Jesús; Fontecha, José Luis; Jurewicz, Izabela; Garriga, Rosa; Muñoz, Edgar

    2016-02-01

    A Love-wave device with graphene oxide (GO) as sensitive layer has been developed for the detection of chemical warfare agent (CWA) simulants. Sensitive films were fabricated by airbrushing GO dispersions onto Love-wave devices. The resulting Love-wave sensors detected very low CWA simulant concentrations in synthetic air at room temperature (as low as 0.2 ppm for dimethyl-methylphosphonate, DMMP, a simulant of sarin nerve gas, and 0.75 ppm for dipropylene glycol monomethyl ether, DPGME, a simulant of nitrogen mustard). High responses to DMMP and DPGME were obtained with sensitivities of 3087 and 760 Hz/ppm respectively. Very low limit of detection (LOD) values (9 and 40 ppb for DMMP and DPGME, respectively) were calculated from the achieved experimental data. The sensor exhibited outstanding sensitivity, good linearity and repeatability to all simulants tested. The detection mechanism is here explained in terms of hydrogen bonding formation between the tested CWA simulants and GO. PMID:26653465

  14. Sensitive and comprehensive detection of chemical warfare agents in air by atmospheric pressure chemical ionization ion trap tandem mass spectrometry with counterflow introduction.

    Science.gov (United States)

    Seto, Yasuo; Sekiguchi, Hiroshi; Maruko, Hisashi; Yamashiro, Shigeharu; Sano, Yasuhiro; Takayama, Yasuo; Sekioka, Ryoji; Yamaguchi, Shintaro; Kishi, Shintaro; Satoh, Takafumi; Sekiguchi, Hiroyuki; Iura, Kazumitsu; Nagashima, Hisayuki; Nagoya, Tomoki; Tsuge, Kouichiro; Ohsawa, Isaac; Okumura, Akihiko; Takada, Yasuaki; Ezawa, Naoya; Watanabe, Susumu; Hashimoto, Hiroaki

    2014-05-01

    A highly sensitive and specific real-time field-deployable detection technology, based on counterflow air introduction atmospheric pressure chemical ionization, has been developed for a wide range of chemical warfare agents (CWAs) comprising gaseous (two blood agents, three choking agents), volatile (six nerve gases and one precursor agent, five blister agents), and nonvolatile (three lachrymators, three vomiting agents) agents in air. The approach can afford effective chemical ionization, in both positive and negative ion modes, for ion trap multiple-stage mass spectrometry (MS(n)). The volatile and nonvolatile CWAs tested provided characteristic ions, which were fragmented into MS(3) product ions in positive and negative ion modes. Portions of the fragment ions were assigned by laboratory hybrid mass spectrometry (MS) composed of linear ion trap and high-resolution mass spectrometers. Gaseous agents were detected by MS or MS(2) in negative ion mode. The limits of detection for a 1 s measurement were typically at or below the microgram per cubic meter level except for chloropicrin (submilligram per cubic meter). Matrix effects by gasoline vapor resulted in minimal false-positive signals for all the CWAs and some signal suppression in the case of mustard gas. The moisture level did influence the measurement of the CWAs. PMID:24678766

  15. 浅谈高技术条件下心理战的防御对策%Psychological Warfare Defense Countermeasures under High Technology Conditions

    Institute of Scientific and Technical Information of China (English)

    李军

    2012-01-01

    未来高技术条件下的战争中,战场环境复杂多变,战争进程迅速激烈,作战样式与战场环境对军人心理影响极大.为了争取战争胜利,减少战争损失,战时军人的心理状态是至关重要的因素.因此,本文针对高技术条件下心理战争的特点,如何筑牢心理防线、强化心理训练、搞好信息控制等方面,提出了一些心理战防御对策.%In future high technology war, the battlefield environment is complicated, war process is quick and fierce, battle style and battlefield environment have a great impact on soldier's psychology. In order to get the victory of war, reduce loss of war, soldier's psychology at war is crucial. The paper analyzes the features of psychological warfare under high technology conditions, and puts forward some defense countermeasures in building psychological lines, strengthening psychological training, and doing well information control.

  16. Pictures of Synthetic Biology

    OpenAIRE

    Cserer, Amelie; Seiringer, Alexandra

    2009-01-01

    This article is concerned with the representation of Synthetic Biology in the media and by biotechnology experts. An analysis was made of German-language media articles published between 2004 and 2008, and interviews with biotechnology-experts at the Synthetic Biology conference SB 3.0 in Zurich 2007. The results have been reflected in terms of the definition of Synthetic Biology, applications of Synthetic Biology and the perspectives of opportunities and risks. In the media, Synthetic Biolog...

  17. Computational Systems Chemical Biology

    OpenAIRE

    Oprea, Tudor I.; May, Elebeoba E.; Leitão, Andrei; Tropsha, Alexander

    2011-01-01

    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically-based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology, SCB (Oprea et al., 2007).

  18. Biology of Blood

    Science.gov (United States)

    ... Mail Facebook TwitterTitle Google+ LinkedIn Home Blood Disorders Biology of Blood Overview of Blood Medical Dictionary Also ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  19. Advances in Biological Science.

    Science.gov (United States)

    Oppenheimer, Steven B.; And Others

    1988-01-01

    Reviews major developments in areas that are at the cutting edge of biological research. Areas include: human anti-cancer gene, recombinant DNA techniques for the detection of Huntington disease carriers, and marine biology. (CW)

  20. Biology is simple.

    Science.gov (United States)

    Newman, Tim

    2015-12-30

    This paper explores the potential for simplicity to reveal new biological understanding. Borrowing selectively from physics thinking, and contrasting with Crick's reductionist philosophy, the author argues that greater emphasis on simplicity is necessary to advance biology and its applications.

  1. Engineering scalable biological systems

    OpenAIRE

    Lu, Timothy K.

    2010-01-01

    Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic, and performing output functions. In the last decade, significant progress has been made in developing basic designs for a wide range of biological circuits in bacteria, yeast, and mammal...

  2. Systems interface biology

    OpenAIRE

    Francis J Doyle; Stelling, Jörg

    2006-01-01

    The field of systems biology has attracted the attention of biologists, engineers, mathematicians, physicists, chemists and others in an endeavour to create systems-level understanding of complex biological networks. In particular, systems engineering methods are finding unique opportunities in characterizing the rich behaviour exhibited by biological systems. In the same manner, these new classes of biological problems are motivating novel developments in theoretical systems approaches. Henc...

  3. Biological Races in Humans

    OpenAIRE

    Templeton, Alan R.

    2013-01-01

    Races may exist in humans in a cultural sense, but biological concepts of race are needed to access their reality in a non-species-specific manner and to see if cultural categories correspond to biological categories within humans. Modern biological concepts of race can be implemented objectively with molecular genetic data through hypothesis-testing. Genetic data sets are used to see if biological races exist in humans and in our closest evolutionary relative, the chimpanzee. Using the two m...

  4. Upgrading Undergraduate Biology Education

    Science.gov (United States)

    Musante, Susan

    2011-01-01

    On many campuses throughout the country, undergraduate biology education is in serious need of an upgrade. During the past few decades, the body of biological knowledge has grown exponentially, and as a research endeavor, the practice of biology has evolved. Education research has also made great strides, revealing many new insights into how…

  5. Biology Myth-Killers

    Science.gov (United States)

    Lampert, Evan

    2014-01-01

    "Biology Myth-Killers" is an activity designed to identify and correct common misconceptions for high school and college introductory biology courses. Students identify common myths, which double as biology misconceptions, and use appropriate sources to share the "truth" about the myths. This learner-centered activity is a fun…

  6. 网络战的冲突分类与法律适用%Analysis ofthe Classification and Legal Issues of Cyber Warfare under International Humanitarian Law

    Institute of Scientific and Technical Information of China (English)

    赵心

    2016-01-01

    在国际人道法下,敌对行动造成的冲突类型的确定,对于确定其法律性质、适用的法律范围都有着不可或缺的地位。随着信息时代的到来,网络攻击行为的法律性质成为争议。如果要判断网络攻击能否适用国际人道法,首先是明确网络攻击引起的冲突的类型,进而确定网络攻击是否属于“武装冲突”范畴。国际人道法如何适用于网络战争,网络攻击构成的冲突能否符合武装冲突的分类,这里将针对这些问题进行探讨和研究。%Under international humanitarian law,the types of conflicts caused by hostile actions are indispensable to the deter-mination of the legal nature and the applicable law.With the advent of the information age,the legal nature of cyber attack has become a dispute.If you want to decide whether international humanitarian law can be applied to cyber attack,the category of conflicts caused by it must be clarified first,and then whether cyber attack belongs to armed conflicts.This paper explores such issues as how international humanitarian law can be applied to cyber warfare,and whether the conflict constitutedby cyber attacks can be classified as armed conflicts.

  7. Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DAN damage in rats

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Min; Yamada, Takanori; Yamano, Shotaro; Kato, Minoru; Kakehashi, Anna; Fujioka, Masaki; Tago, Yoshiyuki; Kitano, Mistuaki; Wanibuchi, Hideki, E-mail: wani@med.osaka-cu.ac.jp

    2013-11-15

    Diphenylarsinic acid (DPAA), a chemical warfare-related neurotoxic organic arsenical, is present in the groundwater and soil in some regions of Japan due to illegal dumping after World War II. Inorganic arsenic is carcinogenic in humans and its organic arsenic metabolites are carcinogenic in animal studies, raising serious concerns about the carcinogenicity of DPAA. However, the carcinogenic potential of DPAA has not yet been evaluated. In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay. Evaluation of the expression of cytochrome P450 (CYP) enzymes in the liver revealed that DPAA induced the expression of CYP1B1, but not any other CYP1, CYP2, or CYP3 enzymes, suggesting that CYP1B1 might be the enzyme responsible for the metabolic activation of DPAA. We also found increased oxidative DNA damage, possibly due to elevated CYP1B1 expression. Induction of CYP1B1 has generally been linked with the activation of AhR, and we found that DPAA activates the aryl hydrocarbon receptor (AhR). Importantly, the promotion effect of DPAA was observed only at a dose that activated the AhR, suggesting that activation of AhR and consequent induction of AhR target genes and oxidative DNA damage plays a vital role in the promotion effects of DPAA. The present study provides, for the first time, evidence regarding the carcinogenicity of DPAA and indicates the necessity of comprehensive evaluation of its carcinogenic potential using long-term carcinogenicity studies. - Highlights: • DPAA, an environmental neurotoxicant, promotes liver carcinogenesis in rats. • DPAA is an activator of AhR signaling pathway. • DPAA promoted oxidative DNA damage in rat livers. • AhR target gene CYP 1B1 might be involved in the metabolism of DPAA.

  8. Comparison of latex body paint with wetted gauze wipes for sampling the chemical warfare agents VX and sulfur mustard from common indoor surfaces.

    Science.gov (United States)

    Hernon-Kenny, Laura A; Behringer, Deborah L; Crenshaw, Michael D

    2016-05-01

    Comparison of solvent-wetted gauze with body paint, a peelable surface sampling media, for the sampling of the chemical warfare agents VX and sulfur mustard from nine surfaces was performed. The nine surfaces sampled are those typical of interior public venues and include smooth, rough, porous, and non-porous surfaces. Overall, solvent-wetted gauze (wipes) performed better for the recovery of VX from non-porous surfaces while body paint (BP) performed better for the porous surfaces. The average percent VX recoveries using wipes and BP, respectively, are: finished wood flooring, 86.2%, 71.4%; escalator handrail, 47.3%, 26.7%; stainless steel, 80.5%, 56.1%; glazed ceramic tile, 81.8%, 44.9%; ceiling tile, 1.77%, 13.1%; painted drywall 7.83%, 21.1%; smooth cement, 0.64%, 10.3%; upholstery fabric, 24.6%, 23.1%; unfinished wood flooring, 9.37%, 13.1%. Solvent-wetted gauze performed better for the recovery of sulfur mustard from three of the relatively non-porous surfaces while body paint performed better for the more porous surfaces. The average percent sulfur mustard recoveries using wipes and BP, respectively, are: finished wood flooring, 30.2%, 2.97%; escalator handrail, 4.40%, 4.09%; stainless steel, 21.2%, 3.30%; glazed ceramic tile, 49.7%, 16.7%; ceiling tile, 0.33%, 11.1%; painted drywall 2.05%, 10.6%; smooth cement, 1.20%, 35.2%; upholstery fabric, 7.63%, 6.03%; unfinished wood flooring, 0.90%, 1.74%. PMID:26990562

  9. Differential detection of a surrogate biological threat agent (Bacillus globigii) with a portable surface plasmon resonance biosensor.

    Science.gov (United States)

    Adducci, Benjamin A; Gruszewski, Hope A; Khatibi, Piyum A; Schmale, David G

    2016-04-15

    New methods and technology are needed to quickly and accurately detect potential biological warfare agents, such as Bacillus anthracis, causal agent of anthrax in humans and animals. Here, we report the detection of a simulant of B. anthracis (B. globigii) alone and in a mixture with a different species of Bacillus to test non-specific interference using a portable surface plasmon resonance (SPR) biosensor (SPIRIT 4.0, Seattle Sensor Systems). Both direct capture and antibody amplification were used to determine the limit of detection for spores of B. globigii, and to detect spores of B. globigii in a mixed sample containing another Bacillus spp. Spores of B. globigii were detected by anti-B. globigii (anti-Bg) coated sensors by direct capture at a concentration of 10(7)spores/mL, and with a secondary antibody amplification at a concentration of 10(5)spores/mL. Spores of B. globigii were differentially detected in a 1:1 mixture with B. pumilus spores from equal concentrations (10(7)spores/mL) with a secondary antibody amplification. To our knowledge, this is the first report of the differential detection of B. globigii with SPR in a mixed sample containing at least one additional Bacillus spp., highlighting the potential for SPR to detect any target bacterium in a mixed sample of closely related species. With the availability of portable instrumentation to accurately detect biological warfare agents such as B. anthracis, emergency responders can implement protocols in a timely fashion, limiting the amount of exposed individuals. PMID:26606307

  10. Synthetic biological networks

    International Nuclear Information System (INIS)

    Despite their obvious relationship and overlap, the field of physics is blessed with many insightful laws, while such laws are sadly absent in biology. Here we aim to discuss how the rise of a more recent field known as synthetic biology may allow us to more directly test hypotheses regarding the possible design principles of natural biological networks and systems. In particular, this review focuses on synthetic gene regulatory networks engineered to perform specific functions or exhibit particular dynamic behaviors. Advances in synthetic biology may set the stage to uncover the relationship of potential biological principles to those developed in physics. (review article)

  11. 电子对抗作战仿真分层半自治Agent系统框架设计%Design of Electronic Warfare Simulation System Framework Based on Semi-autonomous Agent

    Institute of Scientific and Technical Information of China (English)

    成晓鹏; 齐锋; 王枭

    2016-01-01

    In order to redisplay the process of real combat in the electronic warfare simulation system, it designs a layered semi⁃autonomous Agent system framework. Beginning with the point of devising the electronic warfare simulation entity, a new manner of creating entity Agent based on the BDI framework was built and the advantage of semi⁃autonomous Agent was probed. Not only the way how to design Agent became clear, but also the layered semi⁃autonomous Agent structure based on the sort of entities was established. It displays how to use the semi⁃Agent technique in electronic warfare simulation and is re⁃ally significant.%为了在电子对抗作战仿真系统中真实地复现现实作战过程,设计了基于分层半自治Agent的系统框架。从设计电子对抗作战仿真实体Agent的现实意义出发,提出了基于BDI框架的仿真实体Agent设计方法,着重探讨了半自治Agent技术应用于作战仿真领域的巨大优势,明确了个体Agent的设计方法。根据电子对抗作战仿真系统的实体分类结果提出了一种基于分层半自治Agent的系统结构,并分析了不同层次的Agent的功能,为半自治Agent技术应用于电子对抗作战仿真领域提供了思路,具有一定的借鉴意义。

  12. Computational systems chemical biology.

    Science.gov (United States)

    Oprea, Tudor I; May, Elebeoba E; Leitão, Andrei; Tropsha, Alexander

    2011-01-01

    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology (SCB) (Nat Chem Biol 3: 447-450, 2007).The overarching goal of computational SCB is to develop tools for integrated chemical-biological data acquisition, filtering and processing, by taking into account relevant information related to interactions between proteins and small molecules, possible metabolic transformations of small molecules, as well as associated information related to genes, networks, small molecules, and, where applicable, mutants and variants of those proteins. There is yet an unmet need to develop an integrated in silico pharmacology/systems biology continuum that embeds drug-target-clinical outcome (DTCO) triplets, a capability that is vital to the future of chemical biology, pharmacology, and systems biology. Through the development of the SCB approach, scientists will be able to start addressing, in an integrated simulation environment, questions that make the best use of our ever-growing chemical and biological data repositories at the system-wide level. This chapter reviews some of the major research concepts and describes key components that constitute the emerging area of computational systems chemical biology.

  13. Quantum biological information theory

    CERN Document Server

    Djordjevic, Ivan B

    2016-01-01

    This book is a self-contained, tutorial-based introduction to quantum information theory and quantum biology. It serves as a single-source reference to the topic for researchers in bioengineering, communications engineering, electrical engineering, applied mathematics, biology, computer science, and physics. The book provides all the essential principles of the quantum biological information theory required to describe the quantum information transfer from DNA to proteins, the sources of genetic noise and genetic errors as well as their effects. Integrates quantum information and quantum biology concepts; Assumes only knowledge of basic concepts of vector algebra at undergraduate level; Provides a thorough introduction to basic concepts of quantum information processing, quantum information theory, and quantum biology; Includes in-depth discussion of the quantum biological channel modelling, quantum biological channel capacity calculation, quantum models of aging, quantum models of evolution, quantum models o...

  14. Branching processes in biology

    CERN Document Server

    Kimmel, Marek

    2015-01-01

    This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second ex...

  15. Foundations of biology

    OpenAIRE

    Sikorav, Jean-Louis; Braslau, Alan; Goldar, Arach

    2014-01-01

    It is often stated that there are no laws in biology, where everything is contingent and could have been otherwise, being solely the result of historical accidents. Furthermore, the customary introduction of fundamental biological entities such as individual organisms, cells, genes, catalysts and motors remains largely descriptive; constructive approaches involving deductive reasoning appear, in comparison, almost absent. As a consequence, both the logical content and principles of biology ne...

  16. Introducing Aquatic Biology

    OpenAIRE

    Kinne, Otto; Browman, Howard I.; Seaman, Matthias

    2007-01-01

    The Inter-Research Science Center (IR) journals Marine Ecology Progress Series (MEPS) and Aquatic Microbial Ecology (AME) have been receiving increasing numbers of high-quality manuscripts that are principally biological, rather than ecological. With regret, we have had to turn these submissions away. Also, leading limnologists have for many years suggested that IR should provide an outlet for top quality articles on freshwater biology and ecology. Aquatic Biology (...

  17. Glycobiology Current Molecular Biology

    OpenAIRE

    Sabire KARAÇALI

    2003-01-01

    Carbohydrate chemistry evolved into carbohydrate biochemistry and gradually into the biology of carbohydrates, or glycobiology, at the end of the last century. Glycobiology is the new research area of modern molecular biology, and it investigates the structure, biosynthesis and biological functions of glycans. The numbers, linkage types (a or b), positions, binding points and functional group differences of monosaccharides create microheterogeneity. Thus, numerous glycoforms with precise stru...

  18. Biological aerosol background characterization

    Science.gov (United States)

    Blatny, Janet; Fountain, Augustus W., III

    2011-05-01

    To provide useful information during military operations, or as part of other security situations, a biological aerosol detector has to respond within seconds or minutes to an attack by virulent biological agents, and with low false alarms. Within this time frame, measuring virulence of a known microorganism is extremely difficult, especially if the microorganism is of unknown antigenic or nucleic acid properties. Measuring "live" characteristics of an organism directly is not generally an option, yet only viable organisms are potentially infectious. Fluorescence based instruments have been designed to optically determine if aerosol particles have viability characteristics. Still, such commercially available biological aerosol detection equipment needs to be improved for their use in military and civil applications. Air has an endogenous population of microorganisms that may interfere with alarm software technologies. To design robust algorithms, a comprehensive knowledge of the airborne biological background content is essential. For this reason, there is a need to study ambient live bacterial populations in as many locations as possible. Doing so will permit collection of data to define diverse biological characteristics that in turn can be used to fine tune alarm algorithms. To avoid false alarms, improving software technologies for biological detectors is a crucial feature requiring considerations of various parameters that can be applied to suppress alarm triggers. This NATO Task Group will aim for developing reference methods for monitoring biological aerosol characteristics to improve alarm algorithms for biological detection. Additionally, they will focus on developing reference standard methodology for monitoring biological aerosol characteristics to reduce false alarm rates.

  19. Mass of chlorinated volatile organic compounds removed by Pump-and-Treat, Naval Air Warfare Center, West Trenton, New Jersey, 1996-2010

    Science.gov (United States)

    Lacombe, Pierre J.

    2011-01-01

    Pump and Treat (P&T) remediation is the primary technique used to contain and remove trichloroethylene (TCE) and its degradation products cis 1-2,dichloroethylene (cDCE) and vinyl chloride (VC) from groundwater at the Naval Air Warfare Center (NAWC), West Trenton, NJ. Three methods were used to determine the masses of TCE, cDCE, and VC removed from groundwater by the P&T system since it became fully operational in 1996. Method 1, is based on the flow volume and concentrations of TCE, cDCE, and VC in groundwater that entered the P&T building as influent. Method 2 is based on withdrawal volume from each active recovery well and the concentrations of TCE, cDCE, and VC in the water samples from each well. Method 3 compares the maximum monthly amount of TCE, cDCE, and VC from Method 1 and Method 2. The greater of the two values is selected to represent the masses of TCE, cDCE and VC removed from groundwater each month. Previously published P&T monthly reports used Method 1 to determine the mass of TCE, cDCE, and VC removed. The reports state that 8,666 pounds (lbs) of TCE, 13,689 lbs of cDCE, and 2,455 lbs of VC were removed by the P&T system during 1996-2010. By using Method 2, the mass removed was determined to be 8,985 lbs of TCE, 17,801 lbs of cDCE, and 3,056 lbs of VC removed, and Method 3, resulted in 10,602 lbs of TCE, 21,029 lbs of cDCE, and 3,496 lbs of VC removed. To determine the mass of original TCE removed from groundwater, the individual masses of TCE, cDCE, and VC (determined using Methods 1, 2, and 3) were converted to numbers of moles, summed, and converted to pounds of original TCE. By using the molar conversion the mass of original TCE removed from groundwater by Methods 1, 2, and 3 was 32,381 lbs, 39,535 lbs, and 46,452 lbs, respectively, during 1996-2010. P&T monthly reports state that 24,805 lbs of summed TCE, cDCE, and VC were removed from groundwater. The simple summing method underestimates the mass of original TCE removed by the P&T system.

  20. Analysis of chemical warfare agents in organic liquid samples with magnetic dispersive solid phase extraction and gas chromatography mass spectrometry for verification of the chemical weapons convention.

    Science.gov (United States)

    Singh, Varoon; Purohit, Ajay Kumar; Chinthakindi, Sridhar; Goud, Raghavender D; Tak, Vijay; Pardasani, Deepak; Shrivastava, Anchal Roy; Dubey, Devendra Kumar

    2016-05-27

    A simple, sensitive and low temperature sample preparation method is developed for detection and identification of Chemical Warfare Agents (CWAs) and scheduled esters in organic liquid using magnetic dispersive solid phase extraction (MDSPE) followed by gas chromatography-mass spectrometry analysis. The method utilizes Iron oxide@Poly(methacrylic acid-co-ethylene glycol dimethacrylate) resin (Fe2O3@Poly(MAA-co-EGDMA)) as sorbent. Variants of these sorbents were prepared by precipitation polymerization of methacrylic acid-co-ethylene glycol dimethacrylate (MAA-co-EGDMA) onto Fe2O3 nanoparticles. Fe2O3@poly(MAA-co-EGDMA) with 20% MAA showed highest recovery of analytes. Extractions were performed with magnetic microspheres by MDSPE. Parameters affecting the extraction efficiency were studied and optimized. Under the optimized conditions, method showed linearity in the range of 0.1-3.0μgmL(-1) (r(2)=0.9966-0.9987). The repeatability and reproducibility (relative standard deviations (RSDs) %) were in the range of 4.5-7.6% and 3.4-6.2% respectively for organophosphorous esters in dodecane. Limits of detection (S/N=3/1) and limit of quantification (S/N=10/1) were found to be in the range of 0.05-0.1μgmL(-1) and 0.1-0.12μgmL(-1) respectively in SIM mode for selected analytes. The method was successfully validated and applied to the extraction and identification of targeted analytes from three different organic liquids i.e. n-hexane, dodecane and silicon oil. Recoveries ranged from 58.7 to 97.3% and 53.8 to 95.5% at 3μgmL(-1) and 1μgmL(-1) spiking concentrations. Detection of diethyl methylphosphonate (DEMP) and O-Ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) in samples provided by the Organization for Prohibition of Chemical Weapons Proficiency Test (OPCW-PT) proved the utility of the developed method for the off-site analysis of CWC relevant chemicals. PMID:27113675

  1. Effective methylation of phosphonic acids related to chemical warfare agents mediated by trimethyloxonium tetrafluoroborate for their qualitative detection and identification by gas chromatography-mass spectrometry.

    Science.gov (United States)

    Valdez, Carlos A; Leif, Roald N; Alcaraz, Armando

    2016-08-24

    The effective methylation of phosphonic acids related to chemical warfare agents (CWAs) employing trimethyloxonium tetrafluoroborate (TMO·BF4) for their qualitative detection and identification by gas chromatography-mass spectrometry (GC-MS) is presented. The methylation occurs in rapid fashion (1 h) and can be conveniently carried out at ambient temperature, thus providing a safer alternative to the universally employed diazomethane-based methylation protocols. Optimization of the methylation parameters led us to conclude that methylene chloride was the ideal solvent to carry out the derivatization, and that even though methylated products can be observed surfacing after only 1 h, additional time was not found to be detrimental but beneficial to the process particularly when dealing with analytes at low concentrations (∼10 μg mL(-1)). Due to its insolubility in methylene chloride, TMO·BF4 conveniently settles to the bottom during the reaction and does not produce additional interfering by-products that may further complicate the GC-MS analysis. The method was demonstrated to successfully methylate a variety of Schedule 2 phosphonic acids, including their half esters, resulting in derivatives that were readily detected and identified using the instrument's spectral library. Most importantly, the method was shown to simultaneously methylate a mixture of the organophosphorus-based nerve agent hydrolysis products: pinacolyl methylphosphonate (PMPA), cyclohexyl methylphosphonate (CyMPA) and ethyl methylphosphonate (EMPA) (at a 10 μg mL(-1) concentration each) in a fatty acid ester-rich organic matrix (OPCW-PT-O3) featured in the 38th Organisation for the Prohibition of Chemical Weapons (OPCW) Proficiency Test. In addition, the protocol was found to effectively methylate N,N-diethylamino ethanesulfonic acid and N,N-diisopropylamino ethanesulfonic acid that are products arising from the oxidative degradation of the V-series agents VR and VX respectively. The

  2. 施拉姆在美国心理战中的角色扮演以及传播思想%Role and Communication Ideas of Schramm during Psychology Warfare in American History

    Institute of Scientific and Technical Information of China (English)

    柯泽

    2014-01-01

    Several important communication books have created marvelous academic sight since 1990.Theses books are trying to prove such a point:The establishment of American Communication Science is the result of American Psychology Warfare which constituted real war and Cold War in American history.Schramm played important role in Psychology Warfare.His many researches are relevant to that.%20世纪90年代美国出版的一些传播学著作创造了令人惊讶的学术景观,这些著作试图证明:美国传播学学科的发展和建立是美国心理战的产物,心理战争是现实战争以及冷战的重要组成部分,而施拉姆在美国对内对外心理战中扮演了十分特殊的角色,他的许多研究与此密切相关。

  3. 信息化作战轮式车辆装备保障力量的思考%Thinking about Wheeled Vehicle Equipment Support Power for Information Warfare

    Institute of Scientific and Technical Information of China (English)

    陈煜; 贺宇; 王海

    2012-01-01

    Along with the development of IT and the weaponry of high technology, the requirement of information warfare for wheeled vehicle equipment is more and more higher the importance of wheeled vehicle equipment guarantee is also stressed gradually,are the wheeled vehicle equipment necessariness of ensuring strength research also strengthens constantly. This paper makes a thorongh analysis of support power concept and its essential chenaileristics about information warfare wheeled wehicle equipment, and takes a deep thinking about the generation pattern and the way of it anizing.%随着信息技术及高技术武器装备的发展,信息化作战对轮式车辆装备的要求越来越高,轮式车辆装备保障的重要性也日渐突出,轮式车辆装备保障力量研究的必要性也不断加强.在深入分析信息化作战轮式车辆装备保障力量概念和主要特征的基础上,对信息化作战轮式车辆装备保障力量的生成模式和编组方式进行了思考.

  4. Modeling LIDAR Detection of Biological Aerosols to Determine Optimum Implementation Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Sheen, David M.; Aker, Pam M.

    2007-09-19

    This report summarizes work performed for a larger multi-laboratory project named the Background Interferent Measurement and Standards project. While originally tasked to develop algorithms to optimize biological warfare agent detection using UV fluorescence LIDAR, the current uncertainties in the reported fluorescence profiles and cross sections the development of any meaningful models. It was decided that a better approach would be to model the wavelength-dependent elastic backscattering from a number of ambient background aerosol types, and compare this with that generated from representative sporulated and vegetative bacterial systems. Calculations in this report show that a 266, 355, 532 and 1064 nm elastic backscatter LIDAR experiment will allow an operator to immediately recognize when sulfate, VOC-based or road dust (silicate) aerosols are approaching, independent of humidity changes. It will be more difficult to distinguish soot aerosols from biological aerosols, or vegetative bacteria from sporulated bacteria. In these latter cases, the elastic scattering data will most likely have to be combined with UV fluorescence data to enable a more robust categorization.

  5. Integrated Biological Control

    International Nuclear Information System (INIS)

    Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects; and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (apriori) or in response to existing contamination spread (aposteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and apriori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, aposteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response

  6. Biological pretreatment sewages water

    OpenAIRE

    Veselý, Václav

    2009-01-01

    Bachelor's thesis deals with waste water purification at the stage of pre-inflow of water into the biological waste water treatment plants. It is divided into two parts, a theoretical and calculation. The theoretical part deals about sewage water and the method of biological treatment. Design proposal is part of the activation tank for quantity EO.

  7. Experimenting with Mathematical Biology

    Science.gov (United States)

    Sanft, Rebecca; Walter, Anne

    2016-01-01

    St. Olaf College recently added a Mathematical Biology concentration to its curriculum. The core course, Mathematics of Biology, was redesigned to include a wet laboratory. The lab classes required students to collect data and implement the essential modeling techniques of formulation, implementation, validation, and analysis. The four labs…

  8. Biological Macromolecule Crystallization Database

    Science.gov (United States)

    SRD 21 Biological Macromolecule Crystallization Database (Web, free access)   The Biological Macromolecule Crystallization Database and NASA Archive for Protein Crystal Growth Data (BMCD) contains the conditions reported for the crystallization of proteins and nucleic acids used in X-ray structure determinations and archives the results of microgravity macromolecule crystallization studies.

  9. Bioinformatics and School Biology

    Science.gov (United States)

    Dalpech, Roger

    2006-01-01

    The rapidly changing field of bioinformatics is fuelling the need for suitably trained personnel with skills in relevant biological "sub-disciplines" such as proteomics, transcriptomics and metabolomics, etc. But because of the complexity--and sheer weight of data--associated with these new areas of biology, many school teachers feel…

  10. Frontiers in mathematical biology

    CERN Document Server

    1994-01-01

    Volume 100, which is the final volume of the LNBM series serves to commemorate the acievements in two decades of this influential collection of books in mathematical biology. The contributions, by the leading mathematical biologists, survey the state of the art in the subject, and offer speculative, philosophical and critical analyses of the key issues confronting the field. The papers address fundamental issues in cell and molecular biology, organismal biology, evolutionary biology, population ecology, community and ecosystem ecology, and applied biology, plus the explicit and implicit mathematical challenges. Cross-cuttting issues involve the problem of variation among units in nonlinear systems, and the related problems of the interactions among phenomena across scales of space, time and organizational complexity.

  11. Chemical Warfare: Drugs in Sports

    OpenAIRE

    Percy, E. C.

    1980-01-01

    A number of substances have been used by athletes in an attempt to improve performance in sports. The use of these substances, which are referred to as ergogenic aids, has become widespread; some pose serious health hazards. Ergogenic aids are divided into five broad classifications: physiological, physical, psychological, nutritional and chemical. It is possible, although conclusive proof is lacking, that some substances may give an athlete who takes them an advantage over one who does not. ...

  12. The Strategy of Drone Warfare

    Directory of Open Access Journals (Sweden)

    Mike Fowler

    2014-12-01

    Full Text Available There is a budding controversy with the combat use of Remotely Piloted Aircraft (RPA. Also known as Unmanned Aerial Vehicles (UAV, there is a growing literature critiquing the use of RPAs, often using the pejorative term “drone.” RPAs seem to get the blame for a variety of complaints about policy and employment that have little to do with the airframe or its processes. While all of the military functions of an RPA can and are done by manned aircraft, the RPAs must endure additional scrutiny. The decision to employ RPAs requires additional considerations at both the strategic and operational levels of war. This article explores the strategic issues that govern the decisions to employ RPAs in combat. The decision to employ RPAs involves a variety of strategic and operational concerns involving legal issues, technological constraints, operational efficiency, and an interdependency upon information operations.

  13. Basic Concepts in Cyber Warfare

    Directory of Open Access Journals (Sweden)

    Lior Tabansky

    2011-05-01

    Full Text Available Developments in computers have made possible far reaching changes in all areas of life, and the rapid progress in computing, communications, and software has led to a dramatic reduction in the cost of producing, processing, and disseminating information. Information technologies continue to develop at an accelerated pace, and a new era has arisen in the information revolution. The rapid growth in the fields of computing and communications and the ongoing improvement in the performance of computerized systems have created a new space in the world. Cyberspace, a space created not in nature but by human beings. The interface between a new topic that enables unprecedented capabilities, a technical field that demands professional understanding, and mass media that compete for the consumer creates – perhaps predictably – the potential for obfuscation. National security has also been affected by the information revolution and the cyberspace phenomenon. Smart use of new technologies allows previously unknown capabilities, which together with new methods have generated a qualitative change in the military field. However, a public discussion on the issue of cyber security, as of other new hi-tech fields, is lacking in Israel. This essay focuses on the question of national security in light of the cyberspace phenomenon. It aims to survey the field and create a common language for a fruitful public discussion of the developing issue of cyber security, proposing operative definitions for the issues that can be applied in a discussion of Israel’s national security. The essay first addresses the properties of cyberspace, its inherent vulnerabilities, and possible threats within its realm, and then proceeds to related issues of defense, attack, and deterrence in cyberspace.

  14. Warfare, Fiscal Capacity, and Performance

    DEFF Research Database (Denmark)

    Prado, Mauricio; Dincecco, Mark

    We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal innova...... estimate substantial impacts of fiscal capacity on GDP per worker. The results are robust to a broad range of specifications, controls, and sub-samples.......We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal...... innovations, which persisted and helped to shape current fiscal institutions. Economic historians claim that greater fiscal capacity was the key long-run institutional change brought about by historical conflicts. Using casualties sustained in pre-modern wars to instrument for current fiscal institutions, we...

  15. Warfare, Fiscal Capacity, and Performance

    DEFF Research Database (Denmark)

    Dincecco, Mark; Prado, Mauricio

    2012-01-01

    We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal innova...... estimate substantial impacts of fiscal capacity on GDP per worker. The results are robust to a broad range of specifications, controls, and sub-samples.......We exploit differences in casualties sustained in pre-modern wars to estimate the impact of fiscal capacity on economic performance. In the past, states fought different amounts of external conflicts, of various lengths and magnitudes. To raise the revenues to wage wars, states made fiscal...... innovations, which persisted and helped to shape current fiscal institutions. Economic historians claim that greater fiscal capacity was the key long-run institutional change brought about by historical conflicts. Using casualties sustained in pre-modern wars to instrument for current fiscal institutions, we...

  16. Intelligent methods for cyber warfare

    CERN Document Server

    Reformat, Marek; Alajlan, Naif

    2015-01-01

    Cyberwarfare has become an important concern for governmental agencies as well businesses of various types.  This timely volume, with contributions from some of the internationally recognized, leaders in the field, gives readers a glimpse of the new and emerging ways that Computational Intelligence and Machine Learning methods can be applied to address problems related to cyberwarfare. The book includes a number of chapters that can be conceptually divided into three topics: chapters describing different data analysis methodologies with their applications to cyberwarfare, chapters presenting a number of intrusion detection approaches, and chapters dedicated to analysis of possible cyber attacks and their impact. The book provides the readers with a variety of methods and techniques, based on computational intelligence, which can be applied to the broad domain of cyberwarfare.

  17. THE FRAMEWORK OF OPERATIONAL WARFARE

    OpenAIRE

    Jacobs, C.J.

    2012-01-01

    In 1973 het Bernard Brodie se belangwekkende boek, War and Politics verskyn. Hierin is die verhouding tussen oorlog en Politiek, volgens die Amerikaanse ervaring in die twee Wereldoorloë, Korea en Vietnam, ontleed aan die hand van Clausewitz se uitspraak dat oorlog die voortsetting van politiek metander middele is. Sy bevinding was dat Amerikaanse militêre en politieke leiers nie in genoemde oorloë begrip vir mekaar se verantwoordelikheid gehad het nie. Gevolglik het hulIe besluite geneem wat...

  18. THE FRAMEWORK OF OPERATIONAL WARFARE

    Directory of Open Access Journals (Sweden)

    C.J. Jacobs

    2012-02-01

    Full Text Available In 1973 het Bernard Brodie se belangwekkende boek, War and Politics verskyn. Hierin is die verhouding tussen oorlog en Politiek, volgens die Amerikaanse ervaring in die twee Wereldoorloë, Korea en Vietnam, ontleed aan die hand van Clausewitz se uitspraak dat oorlog die voortsetting van politiek metander middele is. Sy bevinding was dat Amerikaanse militêre en politieke leiers nie in genoemde oorloë begrip vir mekaar se verantwoordelikheid gehad het nie. Gevolglik het hulIe besluite geneem wat verreikende negatiewe gevolge vir Amerikaanse belange gehad het.

  19. Communications, radar and electronic warfare

    CERN Document Server

    Graham, Adrian

    2010-01-01

    A practical guide to the principles of radio communications for both civilian and military applications In this book, the author covers both the civilian and military uses of technology, focusing particularly on the applications of radio propagation and prediction. Divided into two parts, the author introduces the basic theory of radio prediction before providing a step-by-step explanation of how this theory can be translated into real-life applications. In addition, the book presents up-to-date systems and methods to illustrate how these applications work in practice. This includes s

  20. Managing biological diversity

    Science.gov (United States)

    Samson, Fred B.; Knopf, Fritz L.

    1993-01-01

    Biological diversity is the variety of life and accompanying ecological processes (Off. Technol. Assess. 1987, Wilcove and Samson 1987, Keystone 1991). Conservation of biological diversity is a major environmental issue (Wilson 1988, Counc. Environ. Quality 1991). The health and future of the earth's ecological systems (Lubchenco et al. 1991), global climate change (Botkin 1990), and an ever-increasing rate in loss of species, communities, and ecological systems (Myers 1990) are among issues drawing biological diversity to the mainstream of conservation worldwide (Int. Union Conserv. Nat. and Nat. Resour. [IUCN] et al. 1991). The legal mandate for conserving biological diversity is now in place (Carlson 1988, Doremus 1991). More than 19 federal laws govern the use of biological resources in the United States (Rein 1991). The proposed National Biological Diversity Conservation and Environmental Research Act (H.R. 585 and S.58) notes the need for a national biological diversity policy, would create a national center for biological diversity research, and recommends a federal interagency strategy for ecosystem conservation. There are, however, hard choices ahead for the conservation of biological diversity, and biologists are grappling with how to set priorities in research and management (Roberts 1988). We sense disillusion among field biologists and managers relative to how to operationally approach the seemingly overwhelming charge of conserving biological diversity. Biologists also need to respond to critics like Hunt (1991) who suggest a tree farm has more biological diversity than an equal area of old-growth forest. At present, science has played only a minor role in the conservation of biological diversity (Weston 1992) with no unified approach available to evaluate strategies and programs that address the quality and quantity of biological diversity (Murphy 1990, Erwin 1992). Although actions to conserve biological diversity need to be clearly defined by

  1. Biology and Mathematics

    Directory of Open Access Journals (Sweden)

    Bascompte, Jordi

    2007-06-01

    Full Text Available Biology has become the new “physics” of mathematics, one of the areas of greatest mathematical applications. In turn, mathematics has provided powerful tools and metaphors to approach the astonishing complexity of biological systems. This has allowed the development of sound theoretical frameworks. Here, I summarize some of the most significant contributions of mathematics to biology, ranging from population genetics, to developmental biology, and to networks of species interactions.La biología se ha convertido en la nueva “física” de las matemáticas, una de las áreas con mayores aplicaciones. Las matemáticas, por su parte, han proporcionado herramientas y metáforas muy poderosas para abordar la increíble complejidad de los sistemas biológicos. Esto ha permitido la génesis de marcos conceptuales sólidos. En este artículo resumo algunas de las aplicaciones más exitosas de las matemáticas a la biología que van desde la genética de poblaciones a la biología del desarrollo y las redes de interacciones ecológicas.

  2. Biological and Chemical Security

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, P J

    2002-12-19

    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  3. Neutron in biology

    Energy Technology Data Exchange (ETDEWEB)

    Niimura, Nobuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    Neutron in biology can provide an experimental method of directly locating relationship of proteins and DNA. However, there are relatively few experimental study of such objects since it takes a lot of time to collect a sufficient number of Bragg reflections and inelastic spectra due to the low flux of neutron illuminating the sample. Since a next generation neutron source of JAERI will be 5MW spallation neutron source and its effective neutron flux will be 10{sup 2} to 10{sup 3} times higher than the one of JRR-3M, neutron in biology will open a completely new world for structural biology. (author)

  4. Biological treatment of concentrated hazardous, toxic, and radionuclide mixed wastes without dilution

    International Nuclear Information System (INIS)

    Approximately 10 percent of all radioactive wastes produced in the U. S. are mixed with hazardous or toxic chemicals and therefore can not be placed in secure land disposal facilities. Mixed wastes containing hazardous organic chemicals are often incinerated, but volatile radioactive elements are released directly into the biosphere. Some mixed wastes do not currently have any identified disposal option and are stored locally awaiting new developments. Biological treatment has been proposed as a potentially safer alternative to incineration for the treatment of hazardous organic mixed wastes, since biological treatment would not release volatile radioisotopes and the residual low-level radioactive waste would no longer be restricted from land disposal. Prior studies have shown that toxicity associated with acetonitrile is a significant limiting factor for the application of biotreatment to mixed wastes and excessive dilution was required to avoid inhibition of biological treatment. In this study, we demonstrate that a novel reactor configuration, where the concentrated toxic waste is drip-fed into a complete-mix bioreactor containing a pre-concentrated active microbial population, can be used to treat a surrogate acetonitrile mixed waste stream without excessive dilution. Using a drip-feed bioreactor, we were able to treat a 90,000 mg/L acetonitrile solution to less than 0.1 mg/L final concentration using a dilution factor of only 3.4. It was determined that the acetonitrile degradation reaction was inhibited at a pH above 7.2 and that the reactor could be modeled using conventional kinetic and mass balance approaches. Using a drip-feed reactor configuration addresses a major limiting factor (toxic inhibition) for the biological treatment of toxic, hazardous, or radioactive mixed wastes and suggests that drip-feed bioreactors could be used to treat other concentrated toxic waste streams, such as chemical warfare materiel

  5. Biological treatment of concentrated hazardous, toxic, andradionuclide mixed wastes without dilution

    Energy Technology Data Exchange (ETDEWEB)

    Stringfellow, William T.; Komada, Tatsuyuki; Chang, Li-Yang

    2004-06-15

    Approximately 10 percent of all radioactive wastes produced in the U. S. are mixed with hazardous or toxic chemicals and therefore can not be placed in secure land disposal facilities. Mixed wastes containing hazardous organic chemicals are often incinerated, but volatile radioactive elements are released directly into the biosphere. Some mixed wastes do not currently have any identified disposal option and are stored locally awaiting new developments. Biological treatment has been proposed as a potentially safer alternative to incineration for the treatment of hazardous organic mixed wastes, since biological treatment would not release volatile radioisotopes and the residual low-level radioactive waste would no longer be restricted from land disposal. Prior studies have shown that toxicity associated with acetonitrile is a significant limiting factor for the application of biotreatment to mixed wastes and excessive dilution was required to avoid inhibition of biological treatment. In this study, we demonstrate that a novel reactor configuration, where the concentrated toxic waste is drip-fed into a complete-mix bioreactor containing a pre-concentrated active microbial population, can be used to treat a surrogate acetonitrile mixed waste stream without excessive dilution. Using a drip-feed bioreactor, we were able to treat a 90,000 mg/L acetonitrile solution to less than 0.1 mg/L final concentration using a dilution factor of only 3.4. It was determined that the acetonitrile degradation reaction was inhibited at a pH above 7.2 and that the reactor could be modeled using conventional kinetic and mass balance approaches. Using a drip-feed reactor configuration addresses a major limiting factor (toxic inhibition) for the biological treatment of toxic, hazardous, or radioactive mixed wastes and suggests that drip-feed bioreactors could be used to treat other concentrated toxic waste streams, such as chemical warfare materiel.

  6. A Molecular Biology Database Digest

    OpenAIRE

    Bry, François; Kröger, Peer

    2000-01-01

    Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18]. As expected, Molecular Biology databases play an essential role in Computational Biology research and development. This paper introduces into current Molecular Biology databases, stressing data modeling, data acquisition, data retrieval, and the integration...

  7. Large Pelagics Biological Survey

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Large Pelagics Biological Survey (LPBS) collects additional length and weight information and body parts such as otoliths, caudal vertebrae, dorsal spines, and...

  8. Hammond Bay Biological Station

    Data.gov (United States)

    Federal Laboratory Consortium — Hammond Bay Biological Station (HBBS), located near Millersburg, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). HBBS was established by...

  9. The Biology of Behaviour.

    Science.gov (United States)

    Broom, D. M.

    1981-01-01

    Discusses topics to aid in understanding animal behavior, including the value of the biological approach to psychology, functional systems, optimality and fitness, universality of environmental effects on behavior, and evolution of social behavior. (DS)

  10. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to...

  11. Insecticides and Biological Control

    Science.gov (United States)

    Furness, G. O.

    1972-01-01

    Use of insecticides has been questioned due to their harmful effects on edible items. Biological control of insects along with other effective practices for checking spread of parasites on crops are discussed. (PS)

  12. Chemistry and biology data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Chemical monitoring data and biological data from field collected samples. This dataset is associated with the following publication: Biales , A., D. Denton , D....

  13. Fishery Biology Database (AGDBS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Basic biological data are the foundation on which all assessments of fisheries resources are built. These include parameters such as the size and age composition of...

  14. Mammalian cell biology

    International Nuclear Information System (INIS)

    This section contains summaries of research on mechanisms of lethality and radioinduced changes in mammalian cell properties, new cell systems for the study of the biology of mutation and neoplastic transformation, and comparative properties of ionizing radiations

  15. Enhanced Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is a database of a variety of biological, reproductive, and energetic data collected from fish on the continental shelf in the northwest Atlantic Ocean....

  16. Precision Measurement in Biology

    Science.gov (United States)

    Quake, Stephen

    Is biology a quantitative science like physics? I will discuss the role of precision measurement in both physics and biology, and argue that in fact both fields can be tied together by the use and consequences of precision measurement. The elementary quanta of biology are twofold: the macromolecule and the cell. Cells are the fundamental unit of life, and macromolecules are the fundamental elements of the cell. I will describe how precision measurements have been used to explore the basic properties of these quanta, and more generally how the quest for higher precision almost inevitably leads to the development of new technologies, which in turn catalyze further scientific discovery. In the 21st century, there are no remaining experimental barriers to biology becoming a truly quantitative and mathematical science.

  17. Mechanical Biological Treatment

    DEFF Research Database (Denmark)

    Bilitewski, B-; Oros, Christiane; Christensen, Thomas Højlund

    2011-01-01

    The basic processes and technologies of composting and anaerobic digestion, as described in the previous chapters, are usually used for specific or source-separated organic waste flows. However, in the 1990s mechanical biological waste treatment technologies (MBT) were developed for unsorted...... or residual waste (after some recyclables removed at the source). The concept was originally to reduce the amount of waste going to landfill, but MBT technologies are today also seen as plants recovering fuel as well as material fractions. As the name suggests the technology combines mechanical treatment...... technologies (screens, sieves, magnets, etc.) with biological technologies (composting, anaerobic digestion). Two main technologies are available: Mechanical biological pretreatment (MBP), which first removes an RDF fraction and then biologically treats the remaining waste before most of it is landfilled...

  18. [Systems biology of cancer].

    Science.gov (United States)

    Barillot, Emmanuel; Calzone, Laurence; Zinovyev, Andrei

    2009-01-01

    Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an interaction network governing essential cellular events such as proliferation, differentiation, cell death...) in order to facilitate the interpretation of molecular profiles of tumors. The translation of these networks into mathematical models allows prediction of the evolution of the system in time and under certain perturbations. As a result, it can not only propose specific target points for pharmaceutical purposes, but also anticipate the evolution of tumors as well as their classifications. These characteristics emphasize the important role of Systems Biology of Cancer in the future of biomedical research.

  19. Thermodynamics of Biological Processes

    Science.gov (United States)

    Garcia, Hernan G.; Kondev, Jane; Orme, Nigel; Theriot, Julie A.; Phillips, Rob

    2012-01-01

    There is a long and rich tradition of using ideas from both equilibrium thermodynamics and its microscopic partner theory of equilibrium statistical mechanics. In this chapter, we provide some background on the origins of the seemingly unreasonable effectiveness of ideas from both thermodynamics and statistical mechanics in biology. After making a description of these foundational issues, we turn to a series of case studies primarily focused on binding that are intended to illustrate the broad biological reach of equilibrium thinking in biology. These case studies include ligand-gated ion channels, thermodynamic models of transcription, and recent applications to the problem of bacterial chemotaxis. As part of the description of these case studies, we explore a number of different uses of the famed Monod–Wyman–Changeux (MWC) model as a generic tool for providing a mathematical characterization of two-state systems. These case studies should provide a template for tailoring equilibrium ideas to other problems of biological interest. PMID:21333788

  20. Vibrations, Quanta and Biology

    CERN Document Server

    Huelga, S F

    2013-01-01

    Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the dynamics of quantum dynamical networks in the presence of an environment and the fruitful interplay that the two may enter. At the hand of three biological phenomena whose understanding is held to require quantum mechanical processes, namely excitation and charge transfer in photosynthetic complexes, magneto-reception in birds and the olfactory sense, we demonstrate that this underlying theme encompasses them all, thus suggesting its wider relevance as an archetypical framework for quantum biology.

  1. EDITORIAL: Physical Biology

    Science.gov (United States)

    Roscoe, Jane

    2004-06-01

    Physical Biology is a new peer-reviewed publication from Institute of Physics Publishing. Launched in 2004, the journal will foster the integration of biology with the traditionally more quantitative fields of physics, chemistry, computer science and other math-based disciplines. Its primary aim is to further the understanding of biological systems at all levels of complexity, ranging from the role of structure and dynamics of a single molecule to cellular networks and organisms. The journal encourages the development of a new biology-driven physics based on the extraordinary and increasingly rich data arising in biology, and provides research directions for those involved in the creation of novel bio-engineered systems. Physical Biology will publish a stimulating combination of full length research articles, communications, perspectives, reviews and tutorials from a wide range of disciplines covering topics such as: Single-molecule studies and nanobiotechnology Molecular interactions and protein folding Charge transfer and photobiology Ion channels; structure, function and ion regulation Molecular motors and force generation Subcellular processes Biological networks and neural systems Modeling aspects of molecular and cell biology Cell-cell signaling and interaction Biological patterns and development Evolutionary processes Novel tools and methods in physical biology Experts in the areas encompassed by the journal's scope have been appointed to the Editorial Scientific Committee and the composition of the Committee will be updated regularly to reflect the developments in this new and exciting field. Physical Biology is free online to everyone in 2004; you are invited to take advantage of this offer by visiting the journal homepage at http://physbio.iop.org This special print edition of Physical Biology is a combination of issues 1 and 2 of this electronic-only journal and it brings together an impressive range of articles in the fields covered, including a popular

  2. Multiscale Biological Materials

    DEFF Research Database (Denmark)

    Frølich, Simon

    2016-01-01

    Materials formed by organisms, also known as biological materials, exhibit outstanding structural properties. The range of materials formed in nature is remarkable and their functions include support, protection, motion, sensing, storage, and maintenance of physiological homeostasis. These complex...... materials are characterized by their hierarchical and composite design, where features with sizes ranging from nanometers to centimeters provide the basis for the functionality of the material. Understanding of biological materials is, while very interesting from a basic research perspective, also valuable...... as inspiration for the development of new materials for medical and technological applications. In order to successfully mimic biological materials we must first have a thorough understanding of their design. As such, the purpose of the characterization of biological materials can be defined as the establishment...

  3. ON ITS WAY TO CLASSICS:WARFARE NARRATION OF HARSH SAND (JING SHA)%走向经典的《惊沙》战争叙事

    Institute of Scientific and Technical Information of China (English)

    唐辉

    2014-01-01

    characters and slow story. In 2011, An Zhanjun's Harsh Sand based on Tough Battle at Linze (Ku Zhan Lin Ze) and developed the narration of the West Route Army in a "most common allegory". The vivid characters, clean actions and proper rhythm in this work resemble what makes a warfare classic.

  4. Synthetic biology: A foundation for multi-scale molecular biology

    OpenAIRE

    Bower, Adam G; McClintock, Maria K; Stephen S. Fong

    2010-01-01

    The field of synthetic biology has made rapid progress in a number of areas including method development, novel applications and community building. In seeking to make biology “engineerable,” synthetic biology is increasing the accessibility of biological research to researchers of all experience levels and backgrounds. One of the underlying strengths of synthetic biology is that it may establish the framework for a rigorous bottom-up approach to studying biology starting at the DNA level. Bu...

  5. Noise in Biology

    OpenAIRE

    Tsimring, Lev S

    2014-01-01

    Noise permeates biology on all levels, from the most basic molecular, sub-cellular processes to the dynamics of tissues, organs, organisms, and populations. The functional roles of noise in biological processes can vary greatly. Along with standard, entropy-increasing effects of producing random mutations, diversifying phenotypes in isogenic populations, limiting information capacity of signaling relays, it occasionally plays more surprising constructive roles by accelerating the pace of evol...

  6. Synthetic biology and biosecurity.

    Science.gov (United States)

    Robienski, Jürgen; Simon, Jürgen

    2014-01-01

    This article discusses the conflict fields and legal questions of synthetic biology, esp. concerning biosecurity. A respective jurisprudential discussion has not taken place yet in Germany apart from few statements and recommendations. But in Germany, Europe and the USA, it is generally accepted that a broad discussion is necessary. This is esp. true for the question of biosecurity and the possible dangers arising from Synthetic Biology. PMID:25845204

  7. Systems cell biology.

    Science.gov (United States)

    Mast, Fred D; Ratushny, Alexander V; Aitchison, John D

    2014-09-15

    Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of cells. Merging technology and computation offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.

  8. [Biologics and mycobacterial diseases].

    Science.gov (United States)

    Tsuyuguchi, Kazunari; Matsumoto, Tomoshige

    2013-03-01

    Various biologics such as TNF-alpha inhibitor or IL-6 inhibitor are now widely used for treatment of rheumatoid arthritis. Many reports suggested that one of the major issues is high risk of developing tuberculosis (TB) associated with using these agents, which is especially important in Japan where tuberculosis still remains endemic. Another concern is the risk of development of nontuberculous mycobacterial (NTM) diseases and we have only scanty information about it. The purpose of this symposium is to elucidate the role of biologics in the development of mycobacterial diseases and to establish the strategy to control them. First, Dr. Tohma showed the epidemiologic data of TB risks associated with using biologics calculated from the clinical database on National Database of Rheumatic Diseases by iR-net in Japan. He estimated TB risks in rheumatoid arthritis (RA) patients to be about four times higher compared with general populations and to become even higher by using biologics. He also pointed out a low rate of implementation of QuantiFERON test (QFT) as screening test for TB infection. Next, Dr. Tokuda discussed the issue of NTM disease associated with using biologics. He suggested the airway disease in RA patients might play some role in the development of NTM disease, which may conversely lead to overdiagnosis of NTM disease in RA patients. He suggested that NTM disease should not be uniformly considered a contraindication to treatment with biologics, considering from the results of recent multicenter study showing relatively favorable outcome of NTM patients receiving biologics. Patients with latent tuberculosis infection (LTBI) should receive LTBI treatment before starting biologics. Dr. Kato, a chairperson of the Prevention Committee of the Japanese Society for Tuberculosis, proposed a new LTBI guideline including active implementation of LTBI treatment, introducing interferon gamma release assay, and appropriate selection of persons at high risk for

  9. Biological Effects of Ionizing Radiation

    Science.gov (United States)

    Ingram, M.; Mason, W. B.; Whipple, G. H.; Howland, J. W.

    1952-04-07

    This report presents a review of present knowledge and concepts of the biological effects of ionizing radiations. Among the topics discussed are the physical and chemical effects of ionizing radiation on biological systems, morphological and physiological changes observed in biological systems subjected to ionizing radiations, physiological changes in the intact animal, latent changes following exposure of biological systems to ionizing radiations, factors influencing the biological response to ionizing radiation, relative effects of various ionizing radiations, and biological dosimetry.

  10. 战储装备器材长效综合防护包装方法研究%Research on Long-term Effective and Comprehensive Protection and Packaging Method of Warfare Miscellaneous Equipment

    Institute of Scientific and Technical Information of China (English)

    张春和; 赵复涛; 吴志斌; 李敏堂

    2011-01-01

    分析了我军战储装备器材防护包装现状,提出了长效综合防护包装的思想,从器材分类、方案设计、工艺规范等方面研究了战储装备器材长效综合防护包装方法,并进行了实例验证和分析。%Current situation of protection and packaging of warfare miscellaneous equipment was analyzed. The theory of long-term effective and comprehensive protection and packaging was put forward. The method of protection and packaging was studied from equipment classification, conceptual design and process specification, which was validated and analyzed with living examples.

  11. Numericaj simujation on the RCS of carrier-based ejectronic warfare aircraft%舰载电子战飞机 RCS 特性数值模拟

    Institute of Scientific and Technical Information of China (English)

    岳奎志; 贾忠湖; 姬金祖; 苏珉

    2014-01-01

    The radar cross section (RCS)character of carrier-based electronic warfare aircraft (CEWA)is studied.The pitch angle of radar waves to the body under combat section is analyzed.By using CATIA,3D models for the CEWA of type A and type B are built.Based on the physical optics and the equivalent electro-magnetic flow method,the RCSPlus software is used to numerically simulate the RCS character of CEWA under UHF-band,X-band and S-band.The detection probability of aircraft by radars is studied in the condition of electronic warfare.And the simulation results are analyzed with the mathematical statistics method.The results show that in low-altitude stealth aircraft design,reducing the RCS of the aircraft with the pitch angle between-7.30°and 14.78°means reducing the detection distance of all the radars 26 km away and 8 km below;under the X-band,the RCS of type A reduces by 40.95% compared with type B of CEWA;and in electronic warfare, the detection distance by the X-band radar of type A reduces by 63.24% compared with that in non-electronic warfare.%对舰载电子战飞机的雷达散射截面(radar cross section,RCS)特性进行研究。分析作战剖面下雷达波对于机体的俯仰角,建立舰载电子战飞机 A 型号和 B 型号的三维 CATIA 模型,基于物理光学法和等效电磁流法,使用 RCSPlus 软件,数值模拟在 UHF、X 和 S 雷达波段下舰载电子战飞机的 RCS 特性,研究电子战条件下飞机被雷达发现概率,并对仿真结果进行数理统计分析。研究结果表明:对低空隐身飞机设计时,要降低俯仰角在-7.30°至14.78°之间飞机的 RCS 值,就可以降低距离26 km 以外、高度8 km 以下的所有雷达的探测距离;舰载电子战飞机 RCS 特性 A 型号与 B 型号相比,在 X 波段下,头向 RCS 减小了40.95%;舰载电子战飞机 A 型号在与无电子战时相比,被 X 波段雷达探测到距离缩短了63.24%。

  12. Fleet research the power of the media in the information warfare and the relative counter-measures%浅论媒体力量在信息战争中的作用及防范措施

    Institute of Scientific and Technical Information of China (English)

    晏国勋

    2012-01-01

    This article describes the change of the modern media.By analyzing the power and the method of the modern media,the article found that the modern media is widely used by information warfare.Besides of it,the modern media produced amazing results in past sorts of military conflicts and political conflicts.In the end,the article sums up some information security measures for our country to prevent and reduce the bad effect maybe brought by modern media which is used by hostile entities.%本文通过描述现代媒体的转变,着重分析了媒体在近期网络战中的力量、发挥的作用以及取得的惊人效果。最后提出了我国在网络战中需要加强的安全防范措施和手段。

  13. Effectiveness Analysis Method Research of Formation Cooperative Anti-submarine Warfare Based on Multi-agent Simulation%基于多Agent仿真的编队协同反潜作战效能分析方法研究

    Institute of Scientific and Technical Information of China (English)

    陆铭华; 吴金平; 董汉权

    2011-01-01

    编队协同反潜作战是一个复杂系统,能不能形成清晰的反潜效能分析思路,建立合适的反潜效能指标体系,并进一步确定合理的效能分析方法,成为编队协同反潜作战效能分析最为关键的环节.在给出编队协同反潜作战领域Agent定义及单个反潜兵力Agent形式化描述的基础上,提出了基于多Agent系统仿真(MASBS)的复杂系统效能分析法(MASBS-CSEA),给出了其定义,提取了三种作战任务模式下的效能分析指标,并基于HLA技术构建了MASBS仿真的联邦体系结构.%Conceiving legible anti-submarine effectiveness analysis ideas and designing appropriate anti-submarine effectiveness indexes system as well as determining reasonable effectiveness analysis method have been the most important aspects of effectiveness analysis in the field of formation cooperative anti-submarine warfare which is a complex system. On the basis of presenting the definition of agent and the formalization description of single anti-submarine force in the field of formation cooperative anti-submarine warfare, MAS-based simulation complex system effectiveness analysis (MASBS- CSEA) method was brought forward including presenting its definition and picking-up effectiveness analysis indexes in three combat task models as well as structuring the federation architecture of MASBS simulation based on HLA.

  14. Research on effectiveness simulation of TCT based on network-centric warfare%基于网络中心战的时敏目标效能仿真研究

    Institute of Scientific and Technical Information of China (English)

    闫晶晶; 许腾

    2016-01-01

    文章基于网络中心战"共享-合作-同步"原理,提出了实时目标航迹数据、图像信息共享、兵力行动在时间和空间上合作以及时间敏感目标同步攻击.根据打击时敏目标的效能指标,建立了目标延时、目标发现概率和目标毁伤概率模型,计算"共享-合作-同步"条件下的时敏目标效能,研究结果表明网络中心战模式能够有效改善各项作战效能指标,是提高作战效能的有效手段.%Based on the principle of sharing-cooperation-synchronization in network-centric warfare ,the real-time target track data and image information sharing ,the cooperation of force action in time and space ,and the time-critical target(TCT) synchronization attack are put forward .In view of the indexes used to evaluate the effectiveness of the TCT ,the models of target time delay and probabilities of target detection and damage are established .The effectiveness of the TCT under the condition of sharing-cooperation-synchronization is computed .The result shows that the combat mode based on the network-centric warfare is able to improve in-dexes of combat effectiveness .

  15. Stochastic Methods in Biology

    CERN Document Server

    Kallianpur, Gopinath; Hida, Takeyuki

    1987-01-01

    The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

  16. Biological races in humans.

    Science.gov (United States)

    Templeton, Alan R

    2013-09-01

    Races may exist in humans in a cultural sense, but biological concepts of race are needed to access their reality in a non-species-specific manner and to see if cultural categories correspond to biological categories within humans. Modern biological concepts of race can be implemented objectively with molecular genetic data through hypothesis-testing. Genetic data sets are used to see if biological races exist in humans and in our closest evolutionary relative, the chimpanzee. Using the two most commonly used biological concepts of race, chimpanzees are indeed subdivided into races but humans are not. Adaptive traits, such as skin color, have frequently been used to define races in humans, but such adaptive traits reflect the underlying environmental factor to which they are adaptive and not overall genetic differentiation, and different adaptive traits define discordant groups. There are no objective criteria for choosing one adaptive trait over another to define race. As a consequence, adaptive traits do not define races in humans. Much of the recent scientific literature on human evolution portrays human populations as separate branches on an evolutionary tree. A tree-like structure among humans has been falsified whenever tested, so this practice is scientifically indefensible. It is also socially irresponsible as these pictorial representations of human evolution have more impact on the general public than nuanced phrases in the text of a scientific paper. Humans have much genetic diversity, but the vast majority of this diversity reflects individual uniqueness and not race. PMID:23684745

  17. Informing Biological Design by Integration of Systems and Synthetic Biology

    OpenAIRE

    Smolke, Christina D.; Silver, Pamela A.

    2011-01-01

    Synthetic biology aims to make the engineering of biology faster and more predictable. In contrast, systems biology focuses on the interaction of myriad components and how these give rise to the dynamic and complex behavior of biological systems. Here, we examine the synergies between these two fields.

  18. Biological therapy of psoriasis

    Directory of Open Access Journals (Sweden)

    Sivamani Raja

    2010-01-01

    Full Text Available The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF-α agents have been associated with a variety of serious and "routine" opportunistic infections.

  19. Epigenetics: Biology's Quantum Mechanics.

    Science.gov (United States)

    Jorgensen, Richard A

    2011-01-01

    The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of two views of the gene - the molecular biological view and the epigenetic view - are explored, and it is argued that the classical molecular biological view is incomplete without incorporation of the epigenetic perspective and that in a sense the molecular biological view has been evolving to include the epigenetic view. Intriguingly, this evolution of the molecular view toward the broader and more inclusive epigenetic view of the gene has an intriguing, if not precise, parallel in the evolution of concepts of atomic physics from Newtonian mechanics to quantum mechanics that are interesting to consider. PMID:22639577

  20. Epigenetics: Biology's Quantum Mechanics

    Directory of Open Access Journals (Sweden)

    Richard A Jorgensen

    2011-04-01

    Full Text Available The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920's and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of two views of the gene - the molecular biological view and the epigenetic view - are explored, and it is argued that the classical molecular biological view is incomplete without incorporation of the epigenetic perspective and that in a sense the molecular biological view has been evolving to include the epigenetic view. Intriguingly, this evolution of the molecular view toward the broader and more inclusive epigenetic view of the gene has an intriguing, if not precise, parallel in the evolution of concepts of atomic physics from Newtonian mechanics to quantum mechanics that are interesting to consider.

  1. The biology of personality.

    Science.gov (United States)

    Mulder, R

    1992-09-01

    Historically, models of personality have generally postulated, or assumed, a link with biology. This century has witnessed a major revision of these ideas with both behavioural and psychoanalytic theorists emphasising life experiences as being largely responsible for behaviour as adults. Challenges to this assumption of the overwhelming importance of life experiences are reviewed. An extensive body of data now exists suggesting that biology contributes significantly to individual variability. This biological contribution occurs at a relatively low level in the central nervous system, best defined as temperament. Further research has suffered from the lack of a cohesive psychobiological model. Cloninger's tridimensional theory of personality is presented as a model which attempts to bridge the gap between theoretical temperamental traits, neurotransmitter function and clinical psychiatry. It is to be hoped that new theoretical models will be formulated which will focus on the importance of temperamental variables in psychiatric disorders.

  2. Biological Soft Robotics.

    Science.gov (United States)

    Feinberg, Adam W

    2015-01-01

    In nature, nanometer-scale molecular motors are used to generate force within cells for diverse processes from transcription and transport to muscle contraction. This adaptability and scalability across wide temporal, spatial, and force regimes have spurred the development of biological soft robotic systems that seek to mimic and extend these capabilities. This review describes how molecular motors are hierarchically organized into larger-scale structures in order to provide a basic understanding of how these systems work in nature and the complexity and functionality we hope to replicate in biological soft robotics. These span the subcellular scale to macroscale, and this article focuses on the integration of biological components with synthetic materials, coupled with bioinspired robotic design. Key examples include nanoscale molecular motor-powered actuators, microscale bacteria-controlled devices, and macroscale muscle-powered robots that grasp, walk, and swim. Finally, the current challenges and future opportunities in the field are addressed.

  3. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Galitski, Timothy P.

    2008-04-01

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  4. Biological and Pharmaceutical Nanomaterials

    Science.gov (United States)

    Kumar, Challa S. S. R.

    2006-01-01

    This first comprehensive yet concise overview of all important classes of biological and pharmaceutical nanomaterials presents in one volume the different kinds of natural biological compounds that form nanomaterials or that may be used to purposefully create them. This unique single source of information brings together the many articles published in specialized journals, which often remain unseen by members of other, related disciplines. Covering pharmaceutical, nucleic acid, peptide and DNA-Chitosan nanoparticles, the book focuses on those innovative materials and technologies needed for the continued growth of medicine, healthcare, pharmaceuticals and human wellness. For chemists, biochemists, cell biologists, materials scientists, biologists, and those working in the pharmaceutical and chemical industries.

  5. Neutron structural biology

    International Nuclear Information System (INIS)

    Neutron structural biology will be one of the most important fields in the life sciences which will interest human beings in the 21st century because neutrons can provide not only the position of hydrogen atoms in biological macromolecules but also the dynamic molecular motion of hydrogen atoms and water molecules. However, there are only a few examples experimentally determined at present because of the lack of neutron source intensity. Next generation neutron source scheduled in JAERI (Performance of which is 100 times better than that of JRR-3M) opens the life science of the 21st century. (author)

  6. Chemical and Biological Kinetics

    Science.gov (United States)

    Emanuel', N. M.

    1981-10-01

    Examples of the application of the methods and ideas of chemical kinetics in various branches of chemistry and biology are considered and the results of studies on the kinetics and mechanisms of autoxidation and inhibited and catalysed oxidation of organic substances in the liquid phase are surveyed. Problems of the kinetics of the ageing of polymers and the principles of their stabilisation are discussed and certain trends in biological kinetics (kinetics of tumour growth, kinetic criteria of the effectiveness of chemotherapy, problems of gerontology, etc.) are considered. The bibliography includes 281 references.

  7. Networks in Cell Biology = Modelling cell biology with networks

    OpenAIRE

    Buchanan, Mark; Caldarelli, Guido; De Los Rios, Paolo; Rao, Francesco; Vendruscolo, M.

    2010-01-01

    The science of complex biological networks is transforming research in areas ranging from evolutionary biology to medicine. This is the first book on the subject, providing a comprehensive introduction to complex network science and its biological applications. With contributions from key leaders in both network theory and modern cell biology, this book discusses the network science that is increasingly foundational for systems biology and the quantitative understanding of living systems. It ...

  8. Systems biology in animal sciences

    NARCIS (Netherlands)

    Woelders, H.; Pas, te M.F.W.; Bannink, A.; Veerkamp, R.F.; Smits, M.A.

    2011-01-01

    Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes an

  9. Nanoparticle-labeled DNA capture elements for detection and identification of biological agents

    Science.gov (United States)

    Kiel, Johnathan L.; Holwitt, Eric A.; Parker, Jill E.; Vivekananda, Jeevalatha; Franz, Veronica

    2004-12-01

    Aptamers, synthetic DNA capture elements (DCEs), can be made chemically or in genetically engineered bacteria. DNA capture elements are artificial DNA sequences, from a random pool of sequences, selected for their specific binding to potential biological warfare or terrorism agents. These sequences were selected by an affinity method using filters to which the target agent was attached and the DNA isolated and amplified by polymerase chain reaction (PCR) in an iterative, increasingly stringent, process. The probes can then be conjugated to Quantum Dots and super paramagnetic nanoparticles. The former provide intense, bleach-resistant fluorescent detection of bioagent and the latter provide a means to collect the bioagents with a magnet. The fluorescence can be detected in a flow cytometer, in a fluorescence plate reader, or with a fluorescence microscope. To date, we have made DCEs to Bacillus anthracis spores, Shiga toxin, Venezuelan Equine Encephalitis (VEE) virus, and Francisella tularensis. DCEs can easily distinguish Bacillus anthracis from its nearest relatives, Bacillus cereus and Bacillus thuringiensis. Development of a high through-put process is currently being investigated.

  10. Situeret interesse i biologi

    DEFF Research Database (Denmark)

    Dohn, Niels Bonderup

    2006-01-01

    Interesse hævdes at spille en vigtig rolle i læring. Med udgangspunkt i interesseteori og situeret læring har jeg foretaget et studium i en gymnasieklasse med biologi på højt niveau, med henblik på at identificere hvilke forhold der har betydning for hvad der fanger elevers interesse. Jeg har...

  11. Water pollution biology

    Energy Technology Data Exchange (ETDEWEB)

    Mason, C.F. [University of Essex, Colchester (United Kingdom). Dept. of Biology

    1996-12-31

    Chapter 4 of this book describes the effects of major types of pollutants on aquatic life. These are: organic pollution, eutrophication, acidification, toxic chemicals, oil, and radioactivity. The review includes an description of some of the methods of assessing the biological impacts of pollution. 50 refs., 8 figs., 3 tabs.

  12. Biology Curriculum Support Document.

    Science.gov (United States)

    North Carolina Dept. of Public Instruction, Raleigh.

    This biology curriculum supplement includes the North Carolina Standard Course of Study Goals, helpful resources, and suggested activities supported by inquiry-based laboratory activities. Contents include a detailed description of content which provides the goals and standards being sough), a materials list for inquiry support labs and…

  13. Molecular Biology of Medulloblastoma

    OpenAIRE

    J Gordon Millichap

    2007-01-01

    Current methods of diagnosis and treatment of medulloblastoma, and the influence of new biological advances in the development of more effective and less toxic therapies are reviewed by researchers at Children’s National Medical Center, The George Washington University, Washington, DC.

  14. Bayes in biological anthropology.

    Science.gov (United States)

    Konigsberg, Lyle W; Frankenberg, Susan R

    2013-12-01

    In this article, we both contend and illustrate that biological anthropologists, particularly in the Americas, often think like Bayesians but act like frequentists when it comes to analyzing a wide variety of data. In other words, while our research goals and perspectives are rooted in probabilistic thinking and rest on prior knowledge, we often proceed to use statistical hypothesis tests and confidence interval methods unrelated (or tenuously related) to the research questions of interest. We advocate for applying Bayesian analyses to a number of different bioanthropological questions, especially since many of the programming and computational challenges to doing so have been overcome in the past two decades. To facilitate such applications, this article explains Bayesian principles and concepts, and provides concrete examples of Bayesian computer simulations and statistics that address questions relevant to biological anthropology, focusing particularly on bioarchaeology and forensic anthropology. It also simultaneously reviews the use of Bayesian methods and inference within the discipline to date. This article is intended to act as primer to Bayesian methods and inference in biological anthropology, explaining the relationships of various methods to likelihoods or probabilities and to classical statistical models. Our contention is not that traditional frequentist statistics should be rejected outright, but that there are many situations where biological anthropology is better served by taking a Bayesian approach. To this end it is hoped that the examples provided in this article will assist researchers in choosing from among the broad array of statistical methods currently available.

  15. Openers for Biology Classes.

    Science.gov (United States)

    Gridley, C. Robert R.

    This teaching guide contains 200 activities that are suitable for openers and demonstrations in biology classes. Details are provided regarding the use of these activities. Some of the broad topics under which the activities are organized include algae, amphibians, bacteria, biologists, crustaceans, dinosaurs, ecology, evolution, flowering plants,…

  16. Biological response modifiers

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1991-10-01

    Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

  17. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Gonçalo Espregueira;

    2016-01-01

    we present an overview of the current sequencing technologies and the methods used in typical high-throughput data analysis pipelines. Subsequently, we contextualize high-throughput DNA sequencing technologies within their applications in non-model organism biology. We include tips regarding managing...

  18. Nuclear physics and biology

    International Nuclear Information System (INIS)

    This paper is about nuclear instrumentation and biological concepts, based on images from appropriate Β detectors. First, three detectors are described: the SOFI detector, for gene mapping, the SOFAS detector, for DNA sequencing and the RIHR detector, for in situ hybridization. Then, the paper presents quantitative imaging in molecular genetic and functional imaging. (TEC)

  19. Antiprotons get biological

    CERN Multimedia

    2003-01-01

    After its final run in September, the first results of the Antiproton Cell Experiment (ACE) look very promising. It was the first experiment to take data on the biological effects of antiproton beams to evaluate the potential of antiprotons in radiation therapy.

  20. Plant Systems Biology (editorial)

    Science.gov (United States)

    In June 2003, Plant Physiology published an Arabidopsis special issue devoted to plant systems biology. The intention of Natasha Raikhel and Gloria Coruzzi, the two editors of this first-of-its-kind issue, was ‘‘to help nucleate this new effort within the plant community’’ as they considered that ‘‘...

  1. Biological trade and markets.

    Science.gov (United States)

    Hammerstein, Peter; Noë, Ronald

    2016-02-01

    Cooperation between organisms can often be understood, like trade between merchants, as a mutually beneficial exchange of services, resources or other 'commodities'. Mutual benefits alone, however, are not sufficient to explain the evolution of trade-based cooperation. First, organisms may reject a particular trade if another partner offers a better deal. Second, while human trade often entails binding contracts, non-human trade requires unwritten 'terms of contract' that 'self-stabilize' trade and prevent cheating even if all traders strive to maximize fitness. Whenever trading partners can be chosen, market-like situations arise in nature that biologists studying cooperation need to account for. The mere possibility of exerting partner choice stabilizes many forms of otherwise cheatable trade, induces competition, facilitates the evolution of specialization and often leads to intricate forms of cooperation. We discuss selected examples to illustrate these general points and review basic conceptual approaches that are important in the theory of biological trade and markets. Comparing these approaches with theory in economics, it turns out that conventional models-often called 'Walrasian' markets-are of limited relevance to biology. In contrast, early approaches to trade and markets, as found in the works of Ricardo and Cournot, contain elements of thought that have inspired useful models in biology. For example, the concept of comparative advantage has biological applications in trade, signalling and ecological competition. We also see convergence between post-Walrasian economics and biological markets. For example, both economists and biologists are studying 'principal-agent' problems with principals offering jobs to agents without being sure that the agents will do a proper job. Finally, we show that mating markets have many peculiarities not shared with conventional economic markets. Ideas from economics are useful for biologists studying cooperation but need

  2. Biological trade and markets

    Science.gov (United States)

    2016-01-01

    Cooperation between organisms can often be understood, like trade between merchants, as a mutually beneficial exchange of services, resources or other ‘commodities’. Mutual benefits alone, however, are not sufficient to explain the evolution of trade-based cooperation. First, organisms may reject a particular trade if another partner offers a better deal. Second, while human trade often entails binding contracts, non-human trade requires unwritten ‘terms of contract’ that ‘self-stabilize’ trade and prevent cheating even if all traders strive to maximize fitness. Whenever trading partners can be chosen, market-like situations arise in nature that biologists studying cooperation need to account for. The mere possibility of exerting partner choice stabilizes many forms of otherwise cheatable trade, induces competition, facilitates the evolution of specialization and often leads to intricate forms of cooperation. We discuss selected examples to illustrate these general points and review basic conceptual approaches that are important in the theory of biological trade and markets. Comparing these approaches with theory in economics, it turns out that conventional models—often called ‘Walrasian’ markets—are of limited relevance to biology. In contrast, early approaches to trade and markets, as found in the works of Ricardo and Cournot, contain elements of thought that have inspired useful models in biology. For example, the concept of comparative advantage has biological applications in trade, signalling and ecological competition. We also see convergence between post-Walrasian economics and biological markets. For example, both economists and biologists are studying ‘principal–agent’ problems with principals offering jobs to agents without being sure that the agents will do a proper job. Finally, we show that mating markets have many peculiarities not shared with conventional economic markets. Ideas from economics are useful for biologists

  3. Biological trade and markets.

    Science.gov (United States)

    Hammerstein, Peter; Noë, Ronald

    2016-02-01

    Cooperation between organisms can often be understood, like trade between merchants, as a mutually beneficial exchange of services, resources or other 'commodities'. Mutual benefits alone, however, are not sufficient to explain the evolution of trade-based cooperation. First, organisms may reject a particular trade if another partner offers a better deal. Second, while human trade often entails binding contracts, non-human trade requires unwritten 'terms of contract' that 'self-stabilize' trade and prevent cheating even if all traders strive to maximize fitness. Whenever trading partners can be chosen, market-like situations arise in nature that biologists studying cooperation need to account for. The mere possibility of exerting partner choice stabilizes many forms of otherwise cheatable trade, induces competition, facilitates the evolution of specialization and often leads to intricate forms of cooperation. We discuss selected examples to illustrate these general points and review basic conceptual approaches that are important in the theory of biological trade and markets. Comparing these approaches with theory in economics, it turns out that conventional models-often called 'Walrasian' markets-are of limited relevance to biology. In contrast, early approaches to trade and markets, as found in the works of Ricardo and Cournot, contain elements of thought that have inspired useful models in biology. For example, the concept of comparative advantage has biological applications in trade, signalling and ecological competition. We also see convergence between post-Walrasian economics and biological markets. For example, both economists and biologists are studying 'principal-agent' problems with principals offering jobs to agents without being sure that the agents will do a proper job. Finally, we show that mating markets have many peculiarities not shared with conventional economic markets. Ideas from economics are useful for biologists studying cooperation but need

  4. Systems biology, emergence and antireductionism.

    Science.gov (United States)

    Kesić, Srdjan

    2016-09-01

    This study explores the conceptual history of systems biology and its impact on philosophical and scientific conceptions of reductionism, antireductionism and emergence. Development of systems biology at the beginning of 21st century transformed biological science. Systems biology is a new holistic approach or strategy how to research biological organisms, developed through three phases. The first phase was completed when molecular biology transformed into systems molecular biology. Prior to the second phase, convergence between applied general systems theory and nonlinear dynamics took place, hence allowing the formation of systems mathematical biology. The second phase happened when systems molecular biology and systems mathematical biology, together, were applied for analysis of biological data. Finally, after successful application in science, medicine and biotechnology, the process of the formation of modern systems biology was completed. Systems and molecular reductionist views on organisms were completely opposed to each other. Implications of systems and molecular biology on reductionist-antireductionist debate were quite different. The analysis of reductionism, antireductionism and emergence issues, in the era of systems biology, revealed the hierarchy between methodological, epistemological and ontological antireductionism. Primarily, methodological antireductionism followed from the systems biology. Only after, epistemological and ontological antireductionism could be supported.

  5. Relations between Intuitive Biological Thinking and Biological Misconceptions in Biology Majors and Nonmajors

    OpenAIRE

    Coley, John D.; Tanner, Kimberly

    2015-01-01

    Research and theory development in cognitive psychology and science education research remain largely isolated. Biology education researchers have documented persistent scientifically inaccurate ideas, often termed misconceptions, among biology students across biological domains. In parallel, cognitive and developmental psychologists have described intuitive conceptual systems—teleological, essentialist, and anthropocentric thinking—that humans use to reason about biology. We hypothesize that...

  6. Biological Threats Detection Technologies

    International Nuclear Information System (INIS)

    Among many decisive factors, which can have the influence on the possibility of decreases the results of use biological agents should be mentioned obligatory: rapid detection and identification of biological factor used, the proper preventive treatment and the medical management. The aims of identification: to identify the factor used, to estimate the area of contamination, to evaluate the possible countermeasure efforts (antibiotics, disinfectants) and to assess the effectiveness of the decontamination efforts (decontamination of the persons, equipment, buildings, environment etc.). The objects of identification are: bacteria and bacteria's spores, viruses, toxins and genetically modified factors. The present technologies are divided into: based on PCR techniques (ABI PRISM, APSIS, BIOVERIS, RAPID), immuno (BADD, RAMP, SMART) PCR and immuno techniques (APDS, LUMINEX) and others (BDS2, LUNASCAN, MALDI). The selected technologies assigned to field conditions, mobile and stationary laboratories will be presented.(author)

  7. Introduction to radiation biology

    International Nuclear Information System (INIS)

    This book is arranged in a logical sequence, starting from radiation physics and radiation chemistry, followed by molecular, subcellular and cellular effects and going on to the level of organism. Topics covered include applied radiobiology like modifiers of radiosensitivity, predictive assay, health physics, human genetics and radiopharmaceuticals. The topics covered are : 1. Radiation Physics, 2. Detection and Measurement of Radiation, 3. Radiation Chemistry, 4. DNA Damage and Repair, 5. Chromosomal Aberrations and Gene Mutations, 6. Cellular Radiobiology 7. Acute Radiation Effects, 8. Delayed Effects of Radiation, 9. Biological Basis of Radiotherapy, 10. Chemical Modifiers of Radiosensitivity, 11. Hyperthermia, 12. High LET Radiations in Cancer, Therapy, 13. Predictive Assays, 14. Radiation Effects on Embryos, 15. Human Radiation Genetics, 16. Radiolabelled Compounds in Biology and Medicine and 17. Radiological Health

  8. Radiation biology for environment

    International Nuclear Information System (INIS)

    Environmental pollution problems such as the green-house effect by increase of CO2, acid rain caused by flue gases, and contamination of chemicals and pesticides in foods and water, have become serious in the world with the rapid development of industry and agriculture. To solve some of these problems, radiation treatment has being applied for the removal of the contaminants from flue gases and waste water from industrial plants. On the other hand, the contribution of radiation biology for these environmental pollution problems is not direct but it has contributed indirectly in many fields. This paper describes the contributions of radiation biology for environment in the following two topics: 1) control of insects and microorganisms, and 2) application of radiation for agricultural wastes

  9. Traceability of biologicals

    DEFF Research Database (Denmark)

    Vermeer, Niels S; Spierings, Irina; Mantel-Teeuwisse, Aukje K;

    2015-01-01

    . Efforts to improve the traceability should, in the short term, be focused toward encouraging health professionals and patients to systematically record and report detailed exposure information. Long-term solutions lie in expanding the accessibility to, and increasing the electronic exchange of exposure......INTRODUCTION: Traceability is important in the postmarketing surveillance of biologicals, since changes in the manufacturing process may give rise to product- or batch-specific risks. With the expected expansion of the biosimilar market, there have been concerns about the ability to trace...... individual products within pharmacovigilance databases. AREAS COVERED: The authors discuss the present challenges in the traceability of biologicals in relation to pharmacovigilance, by exploring the processes involved in ensuring traceability. They explore both the existing systems that are in place...

  10. Biological scaling and physics

    Indian Academy of Sciences (India)

    A R P Rau

    2002-09-01

    Kleiber’s law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as -1/4 in terms of the mass of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  11. Quantum physics meets biology.

    Science.gov (United States)

    Arndt, Markus; Juffmann, Thomas; Vedral, Vlatko

    2009-12-01

    Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the past decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world-view of quantum coherences, entanglement, and other nonclassical effects, has been heading toward systems of increasing complexity. The present perspective article shall serve as a "pedestrian guide" to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future "quantum biology," its current status, recent experimental progress, and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.

  12. Biological scaling and physics.

    Science.gov (United States)

    Rau, A R P

    2002-09-01

    Kleiber's law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as M- 1/4 in terms of the mass M of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  13. Topology in Molecular Biology

    CERN Document Server

    Monastyrsky, Michail Ilych

    2007-01-01

    The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form.

  14. Lagrangians for biological models

    CERN Document Server

    Nucci, M C

    2011-01-01

    We show that a method presented in [S.L. Trubatch and A. Franco, Canonical Procedures for Population Dynamics, J. Theor. Biol. 48 (1974), 299-324] and later in [G.H. Paine, The development of Lagrangians for biological models, Bull. Math. Biol. 44 (1982) 749-760] for finding Lagrangians of classic models in biology, is actually based on finding the Jacobi Last Multiplier of such models. Using known properties of Jacobi Last Multiplier we show how to obtain linear Lagrangians of those first-order systems and nonlinear Lagrangian of the corresponding single second-order equations that can be derived from them, even in the case where those authors failed such as the host-parasite model.

  15. Heritability and biological explanation.

    Science.gov (United States)

    Turkheimer, E

    1998-10-01

    Modern neuroscientific and genetic technologies have provoked intense disagreement between scientists who envision a future in which biogenetic theories will enrich or even replace psychological theories, and others who consider biogenetic theories exaggerated, dehumanizing, and dangerous. Both sides of the debate about the role of genes and brains in the genesis of human behavior have missed an important point: All human behavior that varies among individuals is partially heritable and correlated with measurable aspects of brains, but the very ubiquity of these findings makes them a poor basis for reformulating scientists' conceptions of human behavior. Materialism requires psychological processes to be physically instantiated, but more crucial for psychology is the occasional empirical discovery of behavioral phenomena that are specific manifestations of low-level biological variables. Heritability and psychobiological association cannot be the basis for establishing whether behavior is genetic or biological, because to do so leads only to the banal tautology that all behavior is ultimately based in the genotype and brain.

  16. Male mating biology

    OpenAIRE

    Howell Paul I; Knols Bart GJ

    2009-01-01

    Abstract Before sterile mass-reared mosquitoes are released in an attempt to control local populations, many facets of male mating biology need to be elucidated. Large knowledge gaps exist in how both sexes meet in space and time, the correlation of male size and mating success and in which arenas matings are successful. Previous failures in mosquito sterile insect technique (SIT) projects have been linked to poor knowledge of local mating behaviours or the selection of deleterious phenotypes...

  17. Dominating biological networks.

    Directory of Open Access Journals (Sweden)

    Tijana Milenković

    Full Text Available Proteins are essential macromolecules of life that carry out most cellular processes. Since proteins aggregate to perform function, and since protein-protein interaction (PPI networks model these aggregations, one would expect to uncover new biology from PPI network topology. Hence, using PPI networks to predict protein function and role of protein pathways in disease has received attention. A debate remains open about whether network properties of "biologically central (BC" genes (i.e., their protein products, such as those involved in aging, cancer, infectious diseases, or signaling and drug-targeted pathways, exhibit some topological centrality compared to the rest of the proteins in the human PPI network.To help resolve this debate, we design new network-based approaches and apply them to get new insight into biological function and disease. We hypothesize that BC genes have a topologically central (TC role in the human PPI network. We propose two different concepts of topological centrality. We design a new centrality measure to capture complex wirings of proteins in the network that identifies as TC those proteins that reside in dense extended network neighborhoods. Also, we use the notion of domination and find dominating sets (DSs in the PPI network, i.e., sets of proteins such that every protein is either in the DS or is a neighbor of the DS. Clearly, a DS has a TC role, as it enables efficient communication between different network parts. We find statistically significant enrichment in BC genes of TC nodes and outperform the existing methods indicating that genes involved in key biological processes occupy topologically complex and dense regions of the network and correspond to its "spine" that connects all other network parts and can thus pass cellular signals efficiently throughout the network. To our knowledge, this is the first study that explores domination in the context of PPI networks.

  18. Integrative radiation systems biology.

    Science.gov (United States)

    Unger, Kristian

    2014-01-01

    Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer" of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology. PMID:24411063

  19. [Biological etiologies of transsexualism].

    Science.gov (United States)

    Butty, Anne-Virginie; Bianchi-Demicheli, Francesco

    2016-03-16

    Transsexualism or gender dysphoria is a disorder of sexual identity of unknown etiology. At the biological level, one assumes atypical brain development during certain periods of its formation (genesis) notably during embryogenesis, as a result of altered hormonal influence and a particular genetic polymorphism. This article summarizes the research conducted to date in these three areas only, excluding psycho-social and environmental factors. PMID:27149713

  20. Integrative radiation systems biology

    International Nuclear Information System (INIS)

    Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer” of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology

  1. Biology of infantile hemangioma.

    Science.gov (United States)

    Itinteang, Tinte; Withers, Aaron H J; Davis, Paul F; Tan, Swee T

    2014-01-01

    Infantile hemangioma (IH), the most common tumor of infancy, is characterized by an initial proliferation during infancy followed by spontaneous involution over the next 5-10 years, often leaving a fibro-fatty residuum. IH is traditionally considered a tumor of the microvasculature. However, recent data show the critical role of stem cells in the biology of IH with emerging evidence suggesting an embryonic developmental anomaly due to aberrant proliferation and differentiation of a hemogenic endothelium with a neural crest phenotype that possesses the capacity for endothelial, hematopoietic, mesenchymal, and neuronal differentiation. Current evidence suggests a putative placental chorionic mesenchymal core cell embolic origin of IH during the first trimester. This review outlines the emerging role of stem cells and their interplay with the cytokine niche that promotes a post-natal environment conducive for vasculogenesis involving VEGFR-2 and its ligand VEGF-A and the IGF-2 ligand in promoting cellular proliferation, and the TRAIL-OPG anti-apoptotic pathway in preventing cellular apoptosis in IH. The discovery of the role of the renin-angiotensin system in the biology of IH provides a plausible explanation for the programed biologic behavior and the β-blocker-induced accelerated involution of this enigmatic condition. This crucially involves the vasoactive peptide, angiotensin II, that promotes cellular proliferation in IH predominantly via its action on the ATIIR2 isoform. The role of the RAS in the biology of IH is further supported by the effect of captopril, an ACE inhibitor, in inducing accelerated involution of IH. The discovery of the critical role of RAS in IH represents a novel and fascinating paradigm shift in the understanding of human development, IH, and other tumors in general. PMID:25593962

  2. Biology of Infantile Hemangioma

    OpenAIRE

    Itinteang, Tinte; Withers, Aaron H. J.; Davis, Paul F.; Tan, Swee T.

    2014-01-01

    Infantile hemangioma (IH), the most common tumor of infancy, is characterized by an initial proliferation during infancy followed by spontaneous involution over the next 5–10 years, often leaving a fibro-fatty residuum. IH is traditionally considered a tumor of the microvasculature. However, recent data show the critical role of stem cells in the biology of IH with emerging evidence suggesting an embryonic developmental anomaly due to aberrant proliferation and differentiation of a hemogenic ...

  3. Biological Correlates of Empathy

    Directory of Open Access Journals (Sweden)

    E. Timucin Oral

    2010-04-01

    Full Text Available Empathy can be defined as the capacity to know emotionally what another is experiencing from within the frame of reference of that other person and the capacity to sample the feelings of another or it can be metaphorized as to put oneself in another’s shoes. Although the concept of empathy was firstly described in psychological theories, researches studying the biological correlates of psychological theories have been increasing recently. Not suprisingly, dinamically oriented psychotherapists Freud, Kohut, Basch and Fenichel had suggested theories about the biological correlates of empathy concept and established the basis of this modality decades ago. Some other theorists emphasized the importance of empathy in the early years of lifetime regarding mother-child attachment in terms of developmental psychology and investigated its role in explanation of psychopathology. The data coming from some of the recent brain imaging and animal model studies also seem to support these theories. Although increased activity in different brain regions was shown in many of the brain imaging studies, the role of cingulate cortex for understanding mother-child relationship was constantly emphasized in nearly all of the studies. In addition to these studies, a group of Italian scientists has defined a group of neurons as “mirror neurons” in their studies observing rhesus macaque monkeys. Later, they also defined mirror neurons in human studies, and suggested them as “empathy neurons”. After the discovery of mirror neurons, the hopes of finding the missing part of the puzzle for understanding the biological correlates of empathy raised again. Although the roles of different biological parameters such as skin conductance and pupil diameter for defining empathy have not been certain yet, they are going to give us the opportunity to revise the inconsistent basis of structural validity in psychiatry and to stabilize descriptive validity. In this review, the

  4. Biological Rhythms and Preeclampsia

    OpenAIRE

    Ditisheim, Agnès J.; Dibner, Charna; Philippe, Jacques; Pechère-Bertschi, Antoinette

    2013-01-01

    The impact of impaired circadian rhythm on health has been widely studied in shift workers and trans-meridian travelers. A part from its correlation with sleep and mood disorders, biological rhythm impairment is a recognized risk factor for cardiovascular diseases and breast cancer. Preeclampsia is a major public health issue, associated with a significant maternal and fetal morbidity and mortality worldwide. While the risks factors for this condition such as obesity, diabetes, pre-existing h...

  5. Lung Stem cell biology

    OpenAIRE

    Ardhanareeswaran, Karthikeyan; Mirotsou, Maria

    2013-01-01

    Over the past few years new insights have been added to the study of stem cells in the adult lung. The exploration of the endogenous lung progenitors as well as the study of exogenously delivered stem cell populations holds promise for advancing our understanding of the biology of lung repair mechanisms. Moreover, it opens new possibilities for the use of stem cell therapy for the development of regenerative medicine approaches for the treatment of lung disease. Here, we discuss the main type...

  6. Elements in biological AMS

    International Nuclear Information System (INIS)

    AMS (Accelerator Mass Spectrometry) provides high detection sensitivity for isotopes whose half-lives are between 10 years and 100 million years. 14C is the most developed of such isotopes and is used in tracing natural and anthropogenic organic compounds in the Earth's biosphere. Thirty-three elements in the main periodic table and 17 lanthanides or actinides have long lived isotopes, providing potential tracers for research in elemental biochemistry. Overlap of biologically interesting heavy elements and possible AMS tracers is discussed

  7. Neutrons in biology

    International Nuclear Information System (INIS)

    The start of JRR-3M in 1990 was a great epoch to the neutron scattering research in Japan. Abundant neutron beam generated by the JRR-3M made it possible to widen the research field of neutron scattering in Japan. In the early days of neutron scattering, biological materials were too difficult object to be studied by neutrons not only because of their complexity but also because of the strong incoherent scattering by hydrogen. However, the remarkable development of the recent neutron scattering and its related sciences, as well as the availability of higher flux, has made the biological materials one of the most attractive subjects to be studied by neutrons. In early September 1992, an intensive workshop titled 'Neutrons in Biology' was held in Hitachi City by making use of the opportunity of the 4th International Conference on Biophysics and Synchrotron Radiation (BSR92) held in Tsukuba. The workshop was organized by volunteers who are eager to develop the researches in this field in Japan. Numbers of outstanding neutron scattering biologists from U.S., Europe and Asian countries met together and enthusiastic discussions were held all day long. The editors believe that the presentations at the workshop were so invaluable that it is absolutely adequate to put them on record as an issue of JAERI-M and to make them available for scientists to refer to in order to further promote the research in the future. (author)

  8. Biological heart valves.

    Science.gov (United States)

    Ciubotaru, Anatol; Cebotari, Serghei; Tudorache, Igor; Beckmann, Erik; Hilfiker, Andres; Haverich, Axel

    2013-10-01

    Cardiac valvular pathologies are often caused by rheumatic fever in young adults, atherosclerosis in elderly patients, or by congenital malformation of the heart in children, in effect affecting almost all population ages. Almost 300,000 heart valve operations are performed worldwide annually. Tissue valve prostheses have certain advantages over mechanical valves such as biocompatibility, more physiological hemodynamics, and no need for life-long systemic anticoagulation. However, the major disadvantage of biological valves is related to their durability. Nevertheless, during the last decade, the number of patients undergoing biological, rather than mechanical, valve replacement has increased from half to more than three-quarters for biological implants. Continuous improvement in valve fabrication includes development of new models and shapes, novel methods of tissue treatment, and preservation and implantation techniques. These efforts are focused not only on the improvement of morbidity and mortality of the patients but also on the improvement of their quality of life. Heart valve tissue engineering aims to provide durable, "autologous" valve prostheses. These valves demonstrate adaptive growth, which may avoid the need of repeated operations in growing patients.

  9. Synthetic biology: advancing biological frontiers by building synthetic systems

    OpenAIRE

    Chen, Yvonne Yu-Hsuan; Galloway, Kate E.; Smolke, Christina D.

    2012-01-01

    Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy. We discuss the theoretical foundation, applications, and potential of this emerging field.

  10. Marine molecular biology: An emerging field of biological sciences

    Digital Repository Service at National Institute of Oceanography (India)

    Thakur, N.L.; Jain, R.; Natalio, F.; Hamer, B.; Thakur, A.N.; Muller, W.E.G.

    the sustainable exploration of marine life for human health and welfare, through the cooperation between scientists working in marine biology, molecular biology, microbiology and chemistry disciplines. Several success stories of the applications of molecular...

  11. Synthetic biology: Understanding biological design from synthetic circuits

    OpenAIRE

    Mukherji, Shankar; van Oudenaarden, Alexander

    2009-01-01

    An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological systems — from synthetic promoters to the control of cell–cell interactions — has contributed to our understanding of how endogenous systems are put together and function. Synthetic biological devices allow us to grasp intuitively the ranges of behaviour generated by simple...

  12. Review of Pasteuria penetrans: Biology, Ecology, and Biological Control Potential

    OpenAIRE

    Chen, Z. X.; Dickson, D. W.

    1998-01-01

    Pasteuria penetrans is a mycelial, endospore-forming, bacterial parasite that has shown great potential as a biological control agent of root-knot nematodes. Considerable progress has been made during the last 10 years in understanding its biology and importance as an agent capable of effectively suppressing root-knot nematodes in field soil. The objective of this review is to summarize the current knowledge of the biology, ecology, and biological control potential of P. penetrans and other P...

  13. Bridging the gap between systems biology and synthetic biology

    OpenAIRE

    Liu, Di; Hoynes-O’Connor, Allison; Zhang, Fuzhong

    2013-01-01

    Systems biology is an inter-disciplinary science that studies the complex interactions and the collective behavior of a cell or an organism. Synthetic biology, as a technological subject, combines biological science and engineering, allowing the design and manipulation of a system for certain applications. Both systems and synthetic biology have played important roles in the recent development of microbial platforms for energy, materials, and environmental applications. More importantly, syst...

  14. Biological surface science

    Science.gov (United States)

    Kasemo, Bengt

    2002-03-01

    Biological surface science (BioSS), as defined here is the broad interdisciplinary area where properties and processes at interfaces between synthetic materials and biological environments are investigated and biofunctional surfaces are fabricated. Six examples are used to introduce and discuss the subject: Medical implants in the human body, biosensors and biochips for diagnostics, tissue engineering, bioelectronics, artificial photosynthesis, and biomimetic materials. They are areas of varying maturity, together constituting a strong driving force for the current rapid development of BioSS. The second driving force is the purely scientific challenges and opportunities to explore the mutual interaction between biological components and surfaces. Model systems range from the unique water structures at solid surfaces and water shells around proteins and biomembranes, via amino and nucleic acids, proteins, DNA, phospholipid membranes, to cells and living tissue at surfaces. At one end of the spectrum the scientific challenge is to map out the structures, bonding, dynamics and kinetics of biomolecules at surfaces in a similar way as has been done for simple molecules during the past three decades in surface science. At the other end of the complexity spectrum one addresses how biofunctional surfaces participate in and can be designed to constructively participate in the total communication system of cells and tissue. Biofunctional surfaces call for advanced design and preparation in order to match the sophisticated (bio) recognition ability of biological systems. Specifically this requires combined topographic, chemical and visco-elastic patterns on surfaces to match proteins at the nm scale and cells at the micrometer scale. Essentially all methods of surface science are useful. High-resolution (e.g. scanning probe) microscopies, spatially resolved and high sensitivity, non-invasive optical spectroscopies, self-organizing monolayers, and nano- and microfabrication

  15. Decontamination Strategy for Large Area and/or Equipment Contaminated with Chemical and Biological Agents using a High Energy Arc Lamp (HEAL)

    Energy Technology Data Exchange (ETDEWEB)

    Schoske, Richard [ORNL; Kennedy, Patrick [ORNL; Duty, Chad E [ORNL; Smith, Rob R [ORNL; Huxford, Theodore J [ORNL; Bonavita, Angelo M [ORNL; Engleman, Greg [ORNL; Vass, Arpad Alexander [ORNL; Griest, Wayne H [ORNL; Ilgner, Ralph H [ORNL; Brown, Gilbert M [ORNL

    2009-04-01

    A strategy for the decontamination of large areas and or equipment contaminated with Biological Warfare Agents (BWAs) and Chemical Warfare Agents (CWAs) was demonstrated using a High Energy Arc Lamp (HEAL) photolysis system. This strategy offers an alternative that is potentially quicker, less hazardous, generates far less waste, and is easier to deploy than those currently fielded by the Department of Defense (DoD). For example, for large frame aircraft the United States Air Force still relies on the combination of weathering (stand alone in environment), air washing (fly aircraft) and finally washing the aircraft with Hot Soapy Water (HSW) in an attempt to remove any remaining contamination. This method is laborious, time consuming (upwards of 12+ hours not including decontamination site preparation), and requires large amounts of water (e.g., 1,600+ gallons for a single large frame aircraft), and generates large amounts of hazardous waste requiring disposal. The efficacy of the HEAL system was demonstrated using diisopropyl methyl phosphonate (DIMP) a G series CWA simulant, and Bacillus globigii (BG) a simulant of Bacillus anthracis. Experiments were designed to simulate the energy flux of a field deployable lamp system that could stand-off 17 meters from a 12m2 target area and uniformly expose a surface at 1360 W/m2. The HEAL system in the absence of a catalyst reduced the amount of B. globigii by five orders of magnitude at a starting concentration of 1.63 x 107 spores. In the case of CWA simulants, the HEAL system in the presence of the catalyst TiO2 effectively degraded DIMP sprayed onto a 100mm diameter Petri dish in 5 minutes.

  16. Logical analysis of biological systems

    DEFF Research Database (Denmark)

    Mardare, Radu Iulian

    2005-01-01

    R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005.......R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005....

  17. Is Our Biology to Blame?

    Science.gov (United States)

    Schneider, Scott

    1977-01-01

    Brief analyses of three recent examples of biological determinism: sex roles, overpopulation, and sociobiology, are presented in this article. Also a brief discussion of biological determinism and education is presented. (MR)

  18. Biological treatment of Crohn's disease

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; Bjerrum, Jacob Tveiten; Seidelin, Jakob Benedict;

    2012-01-01

    Introduction of biological agents for the treatment of Crohn's disease (CD) has led to a transformation of the treatment paradigm. Several biological compounds have been approved for patients with CD refractory to conventional treatment: infliximab, adalimumab and certolizumab pegol (and...

  19. American Institute of Biological Sciences

    Science.gov (United States)

    ... About | Newsroom | Contact Us The American Institute of Biological Sciences is the national scientific organization that promotes the ... Education Research AIBS Education is dedicated to improving biological science literacy at all levels of formal and informal ...

  20. Research on the Electronic Warfare System of Upgraded Taiwan Air Force F-16A/B(Block 20)%台军F-16A/B(Block 20)升级后的电子战系统研究

    Institute of Scientific and Technical Information of China (English)

    陈晶; 毛毅; 吴微露

    2012-01-01

    近年来,台湾强调以“非对称”、“资电优势”的思想推动建军,投入巨资进行作战飞机的升级改造,以加强空中作战力量和电子战建设。通过对2012年7月美台签订的台军F-16A/B战斗机升级案的背景、进展以及升级前后机载电子战系统的对比研究,进而分析升级后台军F-16A/B战斗机在电子战系统的性能。%In recent years, Taiwan develops military based on the dissymmetric and advantage information viewpoint, and upgrades bat- tle-planes putting into a large amount of money to enhance the air attack strength and the electronic warfare. The paper explains the perform- ance of the electronic warfare system of upgraded Taiwan' s F-16A/B by analyzing the background and proceeding of Taiwan air force F-16A/ B modernization plan signed on July 2012 and contrasting the electronic warfare system of F-16A/B and upgraded F-16A/B.

  1. Biology of Applied Digital Ecosystems

    OpenAIRE

    Briscoe, G.; Sadedin, S.; Paperin, G.

    2007-01-01

    A primary motivation for our research in Digital Ecosystems is the desire to exploit the self-organising properties of biological ecosystems. Ecosystems are thought to be robust, scalable architectures that can automatically solve complex, dynamic problems. However, the biological processes that contribute to these properties have not been made explicit in Digital Ecosystems research. Here, we discuss how biological properties contribute to the self-organising features of biological ecosystem...

  2. Synthetic Biology for Therapeutic Applications

    OpenAIRE

    Abil, Zhanar; Xiong, Xiong; Zhao, Huimin

    2014-01-01

    Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug d...

  3. Logical impossibilities in biological networks

    Directory of Open Access Journals (Sweden)

    Monendra Grover

    2011-10-01

    Full Text Available Biological networks are complex and involve several kinds of molecules. For proper biological function it is important for these biomolecules to act at an individual level and act at the level of interaction of these molecules. In this paper some of the logical impossibilities that may arise in the biological networks and their possible solutions are discussed. It may be important to understand these paradoxes and their possible solutions in order to develop a holistic view of biological function.

  4. Attitude of teenagers towards biology

    OpenAIRE

    Lavtižar, Teja

    2016-01-01

    ROSE project is a comprehensive study in which students' attitudes towards Science and Technology affected by many factors have been examined. In our study, only some aspects have been focused due to a narrower field of biology which has been interested in, and the direction of the attitude between Biology to elementary school students has been checked. The purpose of the master's work has been to determine the attitude of the teenagers to Biology as science and Biology as a school subjec...

  5. Functions in Biological Kind Classification

    Science.gov (United States)

    Lombrozo, Tania; Rehder, Bob

    2012-01-01

    Biological traits that serve functions, such as a zebra's coloration (for camouflage) or a kangaroo's tail (for balance), seem to have a special role in conceptual representations for biological kinds. In five experiments, we investigate whether and why functional features are privileged in biological kind classification. Experiment 1…

  6. Semiconductor nanostructures in biological applications

    Energy Technology Data Exchange (ETDEWEB)

    Alexson, Dimitri [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Chen Hongfeng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Cho, Michael [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Dutta, Mitra [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Li Yang [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Shi, Peng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Raichura, Amit [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Ramadurai, Dinakar [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Parikh, Shaunak [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Stroscio, Michael A [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Vasudev, Milana [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States)

    2005-07-06

    Semiconductor nanostructures in biological applications are discussed. Results are presented on the use of colloidal semiconductor quantum dots both as biological tags and as structures that interact with and influence biomolecules. Results are presented on the use of semiconducting carbon nanotubes in biological applications. (topical review)

  7. Biological Computing Fundamentals and Futures

    CERN Document Server

    Akula, Balaji

    2009-01-01

    The fields of computing and biology have begun to cross paths in new ways. In this paper a review of the current research in biological computing is presented. Fundamental concepts are introduced and these foundational elements are explored to discuss the possibilities of a new computing paradigm. We assume the reader to possess a basic knowledge of Biology and Computer Science

  8. ECO-BIOLOGICAL SYSTEM MODELING

    Directory of Open Access Journals (Sweden)

    T. I. Burak

    2015-01-01

    Full Text Available The methodology for computer modeling of complex eco-biological models is presented in this paper. It is based on system approach of J. Forrester. Developed methodology is universal for complex ecological and biological systems. Modeling algorithm considers specialties of eco-biological systems and shows adequate and accurate results in practice. 

  9. Allometric Scaling in Biology

    Science.gov (United States)

    Banavar, Jayanth

    2009-03-01

    The unity of life is expressed not only in the universal basis of inheritance and energetics at the molecular level, but also in the pervasive scaling of traits with body size at the whole-organism level. More than 75 years ago, Kleiber and Brody and Proctor independently showed that the metabolic rates, B, of mammals and birds scale as the three-quarter power of their mass, M. Subsequent studies showed that most biological rates and times scale as M-1/4 and M^1/4 respectively, and that these so called quarter-power scaling relations hold for a variety of organisms, from unicellular prokaryotes and eukaryotes to trees and mammals. The wide applicability of Kleiber's law, across the 22 orders of magnitude of body mass from minute bacteria to giant whales and sequoias, raises the hope that there is some simple general explanation that underlies the incredible diversity of form and function. We will present a general theoretical framework for understanding the relationship between metabolic rate, B, and body mass, M. We show how the pervasive quarter-power biological scaling relations arise naturally from optimal directed resource supply systems. This framework robustly predicts that: 1) whole organism power and resource supply rate, B, scale as M^3/4; 2) most other rates, such as heart rate and maximal population growth rate scale as M-1/4; 3) most biological times, such as blood circulation time and lifespan, scale as M^1/4; and 4) the average velocity of flow through the network, v, such as the speed of blood and oxygen delivery, scales as M^1/12. Our framework is valid even when there is no underlying network. Our theory is applicable to unicellular organisms as well as to large animals and plants. This work was carried out in collaboration with Amos Maritan along with Jim Brown, John Damuth, Melanie Moses, Andrea Rinaldo, and Geoff West.

  10. Biology Reflective Assessment Curriculum

    Science.gov (United States)

    Bayley, Cheryl Ann

    Often students and educators view assessments as an obligation and finality for a unit. In the current climate of high-stakes testing and accountability, the balance of time, resources and emphasis on students' scores related to assessment have been slanted considerably toward the summative side. This tension between assessment for accountability and assessment to inform teaching strains instruction and educators' ability to use that information to design learning opportunities that help students develop deeper conceptual understanding. A substantive body of research indicates that formative and reflective assessment can significantly improve student learning. Biology Reflective Assessment Curriculum (BRAC) examines support provided for high school science students through assessment practices. This investigation incorporates the usage of reflective assessments as a guiding practice for differentiated instruction and student choice. Reflective assessment is a metacognitive strategy that promotes self-monitoring and evaluation. The goals of the curriculum are to promote self-efficacy and conceptual understanding in students learning biology through developing their metacognitive awareness. BRAC was implemented in a high school biology classroom. Data from assessments, metacognitive surveys, self-efficacy surveys, reflective journals, student work, a culminating task and field notes were used to evaluate the effectiveness of the curriculum. The results suggest that students who develop their metacognitive skills developed a deeper conceptual understanding and improved feelings of self-efficacy when they were engaged in a reflective assessment unit embedded with student choice. BRAC is a tool for teachers to use assessments to assist students in becoming metacognitive and to guide student choice in learning opportunities.

  11. Modulation of radiosensitivity of biological systems by medicinal herbs

    International Nuclear Information System (INIS)

    The global environmental pollution is responsible for the exposure of living beings to the influence of various technogenic factors, including ionizing radiation. Exposure to such radiation represents a genuine, increasing threat to mankind and our environment. The steadily increasing applications of radiation in clinical practice, industrial and agricultural activities, residual radio-activity resulting from nuclear test explosions, have a measurable impact contributing to significant radiation hazards in humans. Further, the proliferation of terrorism and asymmetric warfare in the 21st century has rendered the modern world a dangerous place to live and work. With the realization of deleterious effects of ionizing radiation, a need was felt to protect human beings against these harmful effects by using physical and/or chemical means. Many chemical compounds have been tested for radio protective action but their practical applicability remained limited owing to their inherent toxicity at the optimum dose level. Various plants have been used for various ailments in humans since time immemorial, and herbal preparations have usually been considered safe and less toxic than the synthetic compounds. Therefore, screening of natural products present a major avenue for the discovery of new radio protective drugs and such products have drawn the attention of investigators during the last two decades. The Indian system of medicine employs a large number of plants and some of these herbals viz. The extracts of certain medicinal plant like Amla (Emblica officinalis), Rosemary (Rosemary officinalis), Methi (Trigonella foenum graecum) sapthaparna (Alstonia scholaris), Bael (Aegle inarmelos), Bhumi amla (Phyllanthus niruri), Jamun (Syzgium cumini), Gloe (Tinospora cordifolia) have been trialed in this laboratory for their radio protective action in various biological systems of mammals. The extracts of various parts of such plants have appreciable DRF on the basis of survival

  12. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun

    2015-01-01

    commitments with differently imagined futures. I argue that promises are constitutive of the stem cell biology, rather than being derivative of it. Since the biological concept of stem cells is predicated on the future that they promise, the biological life of stem cells is inextricably intertwined...... patients’ bodies in anticipation of materializing the promises of stem cell biology, they are produced as a new form of biovaluable. The promises of biology move beyond the closed circuit of scientific knowledge production, and proliferate in the speculative marketplaces of promises. Part II looks at how...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  13. Biological Petri Nets

    CERN Document Server

    Wingender, E

    2011-01-01

    It was suggested some years ago that Petri nets might be well suited to modeling metabolic networks, overcoming some of the limitations encountered by the use of systems employing ODEs (ordinary differential equations). Much work has been done since then which confirms this and demonstrates the usefulness of this concept for systems biology. Petri net technology is not only intuitively understood by scientists trained in the life sciences, it also has a robust mathematical foundation and provides the required degree of flexibility. As a result it appears to be a very promising approach to mode

  14. Biology Attitude Scale

    OpenAIRE

    YEŞİLYURT, Selami; GÜL, Şeyda

    2009-01-01

    The aim of this study is to develop a scale determining secondary school stu- dent’s attitude towards biology. For this aim, at first, totally 92 scale items were prepared by reviewing relevant literature. 88 items in this scale were a five-point Likert type scale. 4 of 92 items consisted of demographic variables. The scale was applied to a sample of 109 students randomly selected from two secondary schools in Erzurum. At the end of this application, SPSS 12.0 Statistical Program was used to ...

  15. Programme Biology - Health protection

    International Nuclear Information System (INIS)

    The scientific results for 1975, of the five-year Biology-Health Protection programme adopted in 1971, are presented in two volumes. In volume one, Research in Radiation Protection are developed exclusively, including the following topics: measurement and interpretation of radiation (dosimetry); transfer of radioactive nuclides in the constituents of the environment; hereditary effects of radiation; short-term effects (acute irradiation syndrome and its treatment); long-term effects and toxicology of radioactive elements. In volume, two Research on applications in Agriculture and Medicine are developed. It includes: mutagenesis; soil-plant relations; radiation analysis; food conservation; cell culture; radioentomology. Research on applications in Medicine include: Nuclear Medicine and Neutron Dosimetry

  16. Biology of Nanobots

    Science.gov (United States)

    Duan, Wentao; Pavlick, Ryan; Sen, Ayusman

    2013-12-01

    One of the more interesting recent discoveries has been the ability to design nano/microbots which catalytically harness the chemical energy in their environment to move autonomously. Their potential applications include delivery of materials, self-assembly of superstructures, and roving sensors. One emergent area of research is the study of their collective behavior and how they emulate living systems. The aim of this chapter is to describe the "biology" of nanobots, summarizing the fundamentals physics behind their motion and how the bots interact with each other to initiate complex emergent behavior.

  17. Mathematics and biology

    International Nuclear Information System (INIS)

    In India and in so many other countries, the science students are generally separated into two main streams: one opting mathematical sciences, the other studying biological sciences. As a result, medicos and biologists have no adequate knowledge of mathematical sciences. It causes a great drawback to them in order to be perfect and updated in their profession, due to the tremendous application of mathematics in bio-sciences, now-a-days. The main aim of this article is to emphasize on the need of the time to produce the mathematico-biologists in abundance for the better service of mankind. (author)

  18. [Woman and race biology].

    Science.gov (United States)

    Hanson, H

    1993-01-01

    Early 20th century race biology takes a special interest in woman as part of the "intra-racial" project of bringing forth healthy and competitive individuals. But there are other motives as well for the race biologist to take an interest in woman. She is believed to develop fewer individual characteristics and is therefore a more typical representative of her race than man. The development level of the race is also presupposed to be discernible by the degree of "gender diformism": a race of higher standing would exhibit a greater difference between the sexes. The anthropologist, anatomist, gynaecologist--or whatever guise the race biologist may adopt-- will, in principle, stress that the relation between the sexes is not a matter of "more or less", but one of differences in kind. In reality, the "more-or-less of comparison is the very cornerstone of the issue. Quantitative differences, directly observed or obtained from statistics, are construed as signs of difference in kind. 18th century medical philosophy and sex-linked anthropology laid the theoretical foundation of the 19th century essentialist conception of woman, which is also that adopted by race biology. Eugenics of social Darwinist inspiration regarded prophylactic health care and social welfare programs with scepticism. A race biology founded on the man-woman dualism could sustain altogether different conclusions. An advanced culture calls for extensive division of labour. An extended childhood renders possible higher development but will also impose higher demands on woman. The protection of the female organism is thus an exigency for any people or race striving to survive and evolve. From society's care for the female organism health care for women and preventive maternity care will emerge. Race biology has been a preeminently German concern, as indicated by the selection of works taken to represent this perspective on woman: Bartels-Ploss' Das Weib, C.H. Stratz' Die Rassenschönheit des Weibes and

  19. [The biologization of ethics].

    Science.gov (United States)

    Moreno Lax, Alejandro

    2010-01-01

    Three ethics exist as a condition of possibility of any possible ethics, following a material and biological foundation. This content argument (not logical-formal) supposes a refutation of the naturalistic fallacy that the analytical philosophy attributes to Hume, in three areas of the ethical human experience: body, society and nature. These are: the ethics of the species [J. Habermas], the ethics of liberation [E. Dussel] and the ethics of the responsibility [H. Jonas]. This material argument is a philosophical foundation to considering for three types of applied ethics: medical bioethics, development ethics and environmental ethics. PMID:20405971

  20. Nutritional Systems Biology

    DEFF Research Database (Denmark)

    Jensen, Kasper

    and network biology has the potential to increase our understanding of how small molecules affect metabolic pathways and homeostasis, how this perturbation changes at the disease state, and to what extent individual genotypes contribute to this. A fruitful strategy in approaching and exploring the field...... of nutritional research is, therefore, to borrow methods that are well established in medical and pharmacological research. In this thesis, we use advanced data-mining tools for the construction of a database with available, state-of-the-art information concerning the interaction of food and its molecular...