Sample records for biological dosemeters

  1. Review of international standards for dosemeters. (United States)

    Behrens, R; Ambrosi, P


    International standards for radiation protection dosemeters are published by the International Electrotechnical Commission and the International Organization for Standardization. Several standards exist side by side, although they treat the same measuring task, and specify different requirements, so that dosemeters of different quality result. In this paper, the quality of dosemeters is compared by calculating the uncertainty of dose measurements for dosemeters, which just basely fulfil the respective standard. The results are related to general yardsticks on uncertainty laid down by international organisations. Furthermore, technical differences are standards and addressed and a method to make them conform is presented.

  2. Passive neutron dosemeter with activation detector

    Energy Technology Data Exchange (ETDEWEB)

    Valero L, C.; Banuelos F, A.; Guzman G, K. A.; Borja H, C. G.; Hernandez D, V. M.; Vega C, H. R., E-mail: [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)


    A passive neutron dosemeter with {sup 197}Au activation detector has been developed. The area dosemeter was made as a 20.5 {phi} x 20.5 cm{sup 2} polyethylene moderator, with a polyethylene pug where a {sup 197}Au foil can be located either parallel or perpendicular to moderator axis. Using Monte Carlo methods, with the MCNP5 code. With the fluence response and the fluence-to-equivalent dose conversion coefficients from ICRP-74, responses to H*(10) were also calculated, these were compared against responses of commercially available neutron area monitors and dosemeters. (Author)

  3. The relative merits of discriminating and non-discriminating dosemeters

    DEFF Research Database (Denmark)

    Marshal, T. O.; Christensen, Palle; Julius, H. W.;


    The need for discriminating and non-discriminating personal dosemeters in the field of radiological protection is examined. The ability of various types of dosemeter to meet these needs is also discussed. It is concluded that there is a need for discriminating dosemeters but in the majority of ca...

  4. Colour dosemeters for high level radiation dosimetry

    DEFF Research Database (Denmark)

    Schönbacher, H.; Coninckx, F.; Miller, A.;


    interpretation or a dose measurement with a simple instrument such as a portable reflecting densitometer in the range of 10(3) to 10(6) Gy. Two projects were investigated: (1) a thin plastic film with a self adhesive tape containing a radiochromic dye which induces a colour change when exposed to ionising...... radiation; and (2) a paint containing a base substance with a pigment. The paint dosemeter remained unaffected by irradiation up to 3 x 10(4) Gy while the film dosemeter showed a measurable colour change from 10(4) Gy to 5 x 10(5) Gy. Above 10(6) Gy the film dosemeter is destroyed by radiation. Samples...

  5. Comparison of main thermoluminescent properties of some TL dosemeters

    DEFF Research Database (Denmark)

    Prokic, M.; Bøtter-Jensen, L.


    Different types of TL dosemeters that are attractive for dosimetry practice were investigated and compared. The aim of this study was to evaluate the TL characteristics of different TL dosemeters using two basically different types of commercially available TL readers. The findings demonstrate...

  6. The increasing need for active dosemeters in the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Hirning, C.R. [Ontario Hydro, Whitby, ON (Canada). Health Physics Dept.


    As a legal and administrative dose limits come down, there is an increasing need in the nuclear industry for greater accuracy in dose measurement, for lower detection limits, and for more rapid reporting of doses, Active (i.e. electronic) dosemeters offer the possibility of substantial improvements in these areas. The advantages of electronic dosemeters are reviewed, some impediments to their more rapid adoption considered, some needs for research and development suggested, and the implications of a change from passive to active dosemeters looked at. A review of the present status of electronic dosemeter testing, standard-setting and system implementation is given. The next major era in the history of radiation dosimetry appears to be well under way. (Author).

  7. Response of Alanine Dosemeter to Heavy Ions

    Institute of Scientific and Technical Information of China (English)

    LiWenjian; SuXu; YangYingjie; YuanJianlei; DangBingrong; WangXiao; MaQiufeng; ZhouLibin; HaoJifang; MaoShuhong


    The amino acid L-α-alanine has been investigated for use as a radiation detector in low and high LET radiation fields[1]. The radiatioa detector is cheap and easy to handle. The radiation inducing free radicals are stable at normal laboratory conditions for doses below 104 Gy over a long period of time, which makes the detector useful for intercomparison and documentation purposes. The dosimetric features of alanine-based electron spin resonance (ESR) detectors in high energy electron beams used in radiotherapy were considered[2]. The 5 mm long alanine detectors were found to be the most suitable for carrying out in vivo dosimetry on patients undergoing electron beam radiotherapy. However, data concerning dosimetry of the alanine dosemeter to heavy charged particles are lacking, especially in China.

  8. Prediction analysis of dose equivalent responses of neutron dosemeters used at a MOX fuel facility. (United States)

    Tsujimura, N; Yoshida, T; Takada, C


    To predict how accurately neutron dosemeters can measure the neutron dose equivalent (rate) in MOX fuel fabrication facility work environments, the dose equivalent responses of neutron dosemeters were calculated by the spectral folding method. The dosemeters selected included two types of personal dosemeter, namely a thermoluminescent albedo neutron dosemeter and an electronic neutron dosemeter, three moderator-based neutron survey meters, and one special instrument called an H(p)(10) monitor. The calculations revealed the energy dependences of the responses expected within the entire range of neutron spectral variations observed in neutron fields at workplaces.

  9. Potential clinical utility of a fibre optic-coupled dosemeter for dose measurements in diagnostic radiology. (United States)

    Jones, A Kyle; Hintenlang, David


    Many types of dosemeters have been investigated for absorbed dose measurements in diagnostic radiology, including ionisation chambers, metal-oxide semiconductor field-effect transistor dosemeters, thermoluminescent dosemeters, optically stimulated luminescence detectors, film and diodes. Each of the aforementioned dosemeters suffers from a critical limitation, either the need to interrogate, or read, the dosemeter to retrieve dose information or large size to achieve adequate sensitivity. This work presents an evaluation of a fibre optic-coupled dosemeter (FOCD) for use in diagnostic radiology dose measurement. This dosemeter is small, tissue-equivalent and capable of providing true real-time dose information. The FOCD has been evaluated for dose linearity, angular dependence, sensitivity and energy dependence at energies, beam qualities and beam quantities relevant to diagnostic radiology. The FOCD displayed excellent dose linearity and high sensitivity, while exhibiting minimal angular dependence of response. However, the dosemeter does exhibit positive energy dependence, and is subject to attenuation of response when bent.

  10. Graphite mixed magnesium borate TL dosemeters for beta ray dosimetry

    DEFF Research Database (Denmark)

    Prokic, M; Christensen, Poul


    Sintered MgB4O7:Dy dosemeters with graphite contents from 1 to 10% were investigated for application for personnel dosimetry. Data are given on dose response, dose threshold, reproducibility, beta energy response and fading. Furthermore, results from practical field experiments are presented...

  11. Radiological environmental monitoring with LiF-700-H dosemeters

    Energy Technology Data Exchange (ETDEWEB)

    Scarnichia, E.; Levanon, I.; Andres, P.; Miani, C.; Ramirez, S., E-mail: [Comision Nacional de Energia Atomica, Centro Atomico Bariloche, Grupo Proteccion Radiologica, Exequiel Bustillo 5AV 9500, R8402AGP San Carlos de Bariloche, Rio Negro (Argentina)


    Since 2008 a radiological environmental monitoring with LiF-700-H has been carried out as a result of increasing the Ra-6 research reactor core power. The information obtained is used to evaluate and to quantify analytically the air kerma rate, the fading and the associated uncertainty by developing software tools (deconvolution and uncertainty algorithms). LiF-700-H dosemeters were chosen because of their high sensitivity to low air kerma rates. They show a very good stability and a negligible fading for two-month working periods. The air kerma rate detection limit (based on the 3{sigma} criterion) during these working periods is about 0.4 n Gy/h. Air kerma rates of about 70 n Gy/h are measured with this detection limit. Following the Nist guidelines, an algorithm was developed in order to find the associated uncertainty. It considers several aspects, such as the source activity decay, distance source-dosemeter during the calibration procedure, irradiation time, calibration factor, dosemeter readout, dosemeter sensitivity, TLD reader stability and fading. The associated uncertainty is found to be about 25% for a 95% confidence interval (k = 2.025), which can be considered acceptable when taking into account the very low air kerma rates estimated. The LiF-700-H response to different energies and its relationship with climate changes over the calendar year are planned as future tasks. (Author)

  12. Household and workplace chemicals as retrospective luminescence dosemeters

    DEFF Research Database (Denmark)

    Thomsen, Kristina Jørkov; Bøtter-Jensen, L.; Murray, A.S.


    In the development of techniques for the retrospective assessment of the close absorbed by communities living and working adjacent to the site of a nuclear accident, attention has concentrated on the use Of natural minerals such as quartz and feldspar as dosemeters. These minerals are widely found...

  13. Evaluation of BICRON NE MCP DXT-RAD passive extremity dosemeter

    CERN Document Server

    Yuen, P S; Frketich, G; Rotunda, J


    Passive extremity dosemeters currently used in dosimetry communities worldwide have shortcomings. In general, an extremity dosemeter has too thick a detector element, and the dosemeter response is highly energy dependent for beta rays with energies ranging from 200 keV to 2 MeV. It often does not have dosemeter identification, causing problems in the chain of custody. It is often read manually, rendering reading/packing operations very labour intensive. As a result of collaboration between AECL and BICRON NE, a new extremity dosemeter, incorporating a highly sensitive LiF:Mg,Cu,P TLD and tentatively code named MCP DXT-RAD, was developed. It has been evaluated for radiological performance against an ISO draft standard for extremity dosemeters in twelve categories: homogeneity, detection threshold, beta ray energy response, beta angular response, photon energy response, photon angular response, reproducibility, stability under various climatic conditions, linearity, residue, self irradiation, and effect of ligh...

  14. Photon and fast neutron dosimetry using aluminium oxide thermoluminescence dosemeters. (United States)

    Santos, J P; Fernandes, A C; Gonçalves, I C; Marques, J G; Carvalho, A F; Santos, L; Cardoso, J; Osvay, M


    Al(2)O(3):Mg,Y thermoluminescence (TL) dosemeters were used to measure photon and fast neutron doses in a fast neutron beam recently implemented at the Portuguese Research Reactor, Nuclear and Technological Institute, Portugal. The activation of Al(2)O(3):Mg,Y by fast neutrons provides information about the fast neutron component by measuring the activity of the reaction products and the self-induced TL signal. Additionally, the first TL reading after irradiation determines the photon dose. The elemental composition of the dosemeters was determined by instrumental neutron activation analysis and by particle induced X-ray emission. Results demonstrate that Al(2)O(3):Mg,Y is an adequate material to discriminate photon and fast neutron fields for reactor dosimetry purposes.

  15. Theoretical aspects of the design of a passive radon dosemeter. (United States)

    Wilkinson, P; Saunders, B J


    Some mathematical aspects of the development and design of a passive radon dosemeter are considered. In particular, a mathematical model is presented that is concerned with the gaseous diffusion of radon into a confined region bounded by a plastic material of known diffusion coefficient. The relationship between the time-integrated radon concentrations, inside and outside a sealed plastic container are derived. Estimates of the exposure of people to radon can be made using the time integrated radon concentration inside a calibrated container containing a CR-39 etched-track device. As a consequence of the analysis, it is possible to design a passive radon dosemeter that will be accurate, resistant to moisture and whose response will be independent of rapid variations in radon concentration. The possibility of using a container of this type for the measurement of diffusion coefficients is discussed.

  16. Development of active environmental and personal neutron dosemeters. (United States)

    Nakamura, T; Nunomiya, T; Sasaki, M


    For neutron dosimetry in the radiation environment surrounding nuclear facilities, two types of environmental neutron dosemeters, the high-sensitivity rem counter and the high-sensitivity multi-moderator, the so-called Bonner ball, have been developed and the former is commercially available from Fuji Electric Co. By using these detectors, the cosmic ray neutrons at sea level have been sequentially measured for about 3 y to investigate the time variation of neutron spectrum and ambient dose equivalent influenced by cosmic and terrestrial effects. Our Bonner ball has also been selected as the neutron detector in the International Space Station and has already been used to measure neutrons in the US experimental module. The real time wide-range personal neutron dosemeter which uses two silicon semiconductor detectors has been developed for personal dosimetry and is commercially available from Fuji Electric Co. This dosemeter has good characteristics, fitted to the fluence-to-dose conversion factor in the energy range from thermal energies to several tens of mega-electron-volts and is now widely used in various nuclear facilities.

  17. New concept of IEC standards for radiation protection dosemeters. (United States)

    Ambrosi, P; Behrens, R


    The International Electrotechnical Commission (IEC) develops new standards for radiation protection dosemeters which follow a new concept. They are much more flexible in detail, but still ensure the same measurement quality. They are, for example, no longer specific for the detector type, but rather specific for the measurement task, e.g. for individual monitoring with active direct-reading instruments. Another example is that they are flexible with respect to the ranges of influence quantities. The conceptual changes are described in this paper, together with the advantages this new concept provides for manufacturers, users and legislators.

  18. Type testing of the Siemens Plessey electronic personal dosemeter

    Energy Technology Data Exchange (ETDEWEB)

    Hirning, C.R. [Ontario Hydro, Health Physics Dept., Whitby, Ontario (Canada); Yuen, P.S


    This paper presents the results of a laboratory assessment of the performance of a new type of personal dosimeter, the Electronic Personal Dosemeter made by Siemens Plessey Controls Limited. Twenty pre-production dosimeters and a reader were purchased by Ontario Hydro for the assessment. Tests were performed on radiological performance, including reproducibility, accuracy, linearity, detection threshold, energy response, angular response, neutron response, and response time. There were also tests on the effects of a variety of environmental factors, such as temperature, humidity, pulsed magnetic and electric fields, low- and high-frequency electromagnetic fields, light exposure, drop impact, vibration, and splashing. Other characteristics that were tested were alarm volume, clip force, and battery life. The test results were compared with the relevant requirements of three standards: an Ontario Hydro standard for personal alarming dosimeters, an International Electrotechnical Commission draft standard for direct reading personal dose monitors, and an International Electrotechnical Commission standard for thermoluminescence dosimetry systems for personal monitoring. In general, the performance of the Electronic Personal Dosemeter was found to be quite acceptable: it met most of the relevant requirements of the three standards. However, the following deficiencies were found: slow response time; sensitivity to high-frequency electromagnetic fields; poor resistance to dropping and an alarm that was not loud enough. In addition, the response of the electronic personal dosimeter to low-energy beta rays may be too low for some applications. Problems were experienced with the reliability of operation of the pre-production dosimeters used in these tests. (author)

  19. Tupe testing of the Siemens Plessey electronic personal dosemeter

    Energy Technology Data Exchange (ETDEWEB)

    Hirning, C.R. [Ontario Hydro, Whitby, Ontario (Canada); Yuen, P.S. [Chalk River Laboratories, Chalk River, Ontario (Canada)


    This paper presents the results of a laboratory assessment of the performance of a new type of personal dosimeter, the Electronic Personal Dosemeter made by Siemens Plessey Controls Limited. Twenty pre-production dosimeters and a reader were purchased by Ontario Hydro for the assessment. Tests were performed on radiological performance, including reproducibility, accuracy, linearity, detection threshold, energy response, angular response, neutron response, and response time. There were also tests on the effects of a variety of environmental factors, such as temperature, humidity, pulsed magnetic and electric fields, low- and high-frequency electromagnetic fields, light exposure, drop impact, vibration, and splashing. Other characteristics that were tested were compared with the relevant requirements of three standards: an Ontario Hydro standard for personal alarming dosimeters, an International Electrotechnical Commission draft standard for direct reading personal dose monitors, and an International Electrotechnical Commission standard for thermoluminescence dosimetry systems for personal monitoring. In general, the performance of the Electronic Personal Dosemeter was found to be quite acceptable: it met most of the relevant requirements of the three standards. However, the following deficiencies were found: slow response time; sensitivity to high-frequency electromagnetic fields; poor resistance to dropping; and an alarm that was not loud enough. In addition, the response of the electronic personal dosimeter to low-energy beta rays may be too low for some applications. Problems were experienced with the reliability of operation of the pre-production dosimeters used in these tests. 11 refs., 8 figs., 24 tabs.

  20. Type testing of the Siemens Plessey electronic personal dosemeter. (United States)

    Hirning, C R; Yuen, P S


    This paper presents the results of a laboratory assessment of the performance of a new type of personal dosimeter, the Electronic Personal Dosemeter made by Siemens Plessey Controls Limited. Twenty pre-production dosimeters and a reader were purchased by Ontario Hydro for the assessment. Tests were performed on radiological performance, including reproducibility, accuracy, linearity, detection threshold, energy response, angular response, neutron response, and response time. There were also tests on the effects of a variety of environmental factors, such as temperature, humidity, pulsed magnetic and electric fields, low- and high-frequency electromagnetic fields, light exposure, drop impact, vibration, and splashing. Other characteristics that were tested were alarm volume, clip force, and battery life. The test results were compared with the relevant requirements of three standards: an Ontario Hydro standard for personal alarming dosimeters, an International Electrotechnical Commission draft standard for direct reading personal dose monitors, and an International Electrotechnical Commission standard for thermoluminescence dosimetry systems for personal monitoring. In general, the performance of the Electronic Personal Dosemeter was found to be quite acceptable: it met most of the relevant requirements of the three standards. However, the following deficiencies were found: slow response time; sensitivity to high-frequency electromagnetic fields; poor resistance to dropping; and an alarm that was not loud enough. In addition, the response of the electronic personal dosimeter to low-energy beta rays may be too low for some applications. Problems were experienced with the reliability of operation of the pre-production dosimeters used in these tests.

  1. Dosimetric characteristics of a TLD dosemeter with extremities; Caracteristicas dosimetricas de un dosimetro TLD de extremidades

    Energy Technology Data Exchange (ETDEWEB)

    Molina P, D.; Diaz B, E.; Lien V, R. [Centro de Proteccion e Higiene de las Radiaciones, CPHR, Apdo.Postal 6195, Habana 6, CP 10600, Ciudad Habana (Cuba)


    It was designed a TLD dosemeter for the monitoring of the extremities. This one consists in a metallic ring with a circular orifice where is arranged a T L detector of LiF: Mg,Ti (Model JR1152C) 5 x 5 x 0.8 mm{sup 3} covered by a polyethylene fine layer. In this work were studied the dosimetric properties of the dosemeter for its application in the dosimetry of extremities for photonic radiation. the results obtained allow conclude that the designed dosemeter can be used for the extremities monitoring. (Author)

  2. Type testing of personal dosemeters for photon energy and angular response

    DEFF Research Database (Denmark)

    Julius, H.W.; Marshall, T.O.; Christensen, Poul;


    Performance criteria for personal dosemeters have been recently proposed in the CEC document 'Technical Recommendations for Monitoring Individuals Occupationally Exposed to External Radiation' (EUR 5287, Revised). The current experiment was carried out to demonstrate that TLD-based dosimetry...

  3. Determination of relevant parameters for the use of electronic dosemeters in pulsed fields of ionising radiation. (United States)

    Zutz, H; Hupe, O; Ambrosi, P; Klammer, J


    Active electronic dosemeters using counting techniques are used for radioprotection purposes in pulsed radiation fields in X-ray diagnostics or therapy. The disadvantage of the limited maximum measurable dose rate becomes significant in these radiation fields and leads to some negative effects. In this study, a set of relevant parameters for a dosemeter is described, which can be used to decide whether it is applicable in a given radiation field or not. The determination of these relevant parameters-maximum measurable dose rate in the radiation pulse, dead time of the dosemeter, indication per counting event and measurement cycle time-is specified. The results of the first measurements on the determination of these parameters for an electronic personal dosemeter of the type Thermo Fisher Scientific EPD Mk2 are shown.

  4. Sensitivity of a LR-115 based radon dosemeter

    CERN Document Server

    Bagnoli, F; Bucci, S


    The first results of a study on the sensitivity of a LR-115 based radon dosemeter as a function of the absorber thickness are presented. The theoretical sensitivity was analytically calculated considering a constant detector response to alpha particles within a given energy range and up to a critical angle of incidence. The results are presented in two extreme situations: i) both radon and its decay products uniformly distributed in the chamber volume; ii) radon decay products uniformly deposited on the chamber walls. The agreement with the experimental curve shape appears better in the former case, suggesting that either the parameter values of the model could be different from the chosen values, or the model was too simplified.

  5. 1983 ORNL intercomparison of personnel neutron and gamma dosemeters

    Energy Technology Data Exchange (ETDEWEB)

    Swaja, R.E.; Sims, C.S.; Greene, R.T.


    The Ninth Personnel Dosimetry Intercomparison Study was conducted during April 19-21, 1983, at the Oak Ridge National Laboratory. Dosemeters from 33 participating agencies were mounted on water-filled polyethylene elliptical phantoms and exposed to a range of low-level dose equivalents (0.02-0.45 mSv gamma and 0.49-11.14 mSv neutron) which could be encountered during routine personnel monitoring in mixed radiation fields. The Health Physics Research Reactor served as the radiation source for six separate exposures which used four different shield conditions: unshielded and shielded with steel, steel/concrete, and concrete. Results of the neutron measurements indicate that it is not unusual for dose equivalent estimates made under the same conditions by different agencies to differ by more than a factor of 2. Albedo systems, which were the most popular neutron monitors in this study, provided the most accurate results with CR-39 recoil track being least accurate. Track and film neutron systems exhibited problems providing measurable indication of neutron exposure at dose equivalents of about 0.50 mSv. Gamma measurements showed that TLD and film systems generally overestimated dose equivalents in the mixed radiation fields with film exhibiting significant problems providing measurable indication of gamma exposure at dose equivalents lower than about 0.15 mSv. Under the conditions of this study in which exposures were carefully controlled and participants had information concerning exposure conditions and incident spectra prior to dosemeter analysis, only slightly more than half of all neutron and gamma dose equivalent estimates met regulatory accuracy standards relative to reference values. These results indicate that continued improvement of mixed-field personnel dosimetry is required by many participating organizations. 15 references, 30 tables.

  6. Numerical and experimental results of the operational neutron dosemeter 'Saphydose-N'. (United States)

    Lahaye, T; Chau, Q; Ménard, S; Ndontchueng-Moyo, M; Bolognese-Milsztajn, T; Rannou, A


    Since 1993, the Institute for Radiological Protection and Nuclear Safety (IRSN) has lead, in association with Electricité de France (EDF), a R&D study of a neutron personal electronic dosemeter. This dosemeter, called 'Saphydose-N', is manufactured by the SAPHYMO company. This paper presents first the optimisation of some detector components using Monte Carlo calculations, and second the test of the manufactured Saphydose-N under radiation following the IEC 1323 standard's recommendations for active personal neutron dosemeters. The measurements with the manufactured dosemeter were performed on the one hand at PTB (Physikalisch-Technische Bundesanstalt) in mono-energetic neutron fields and, on the other hand at IRSN in neutron fields generated by a thermal facility (SIGMA), radionuclide ISO sources and a realistic spectrum (CANEL/T400). The manufactured dosemeter Saphydose-N was also tested during measurement campaigns of the European programme EVIDOS ('Evaluation of Individual Dosimetry in Mixed Neutron and Photon Radiation Fields') at different nuclear workplaces. The study showed that Saphydose-N complies with the recommendations of standard IEC 1323 and can be used at any workplace with no previous knowledge of the neutron field characteristics.

  7. Eurados trial performance test for personal dosemeters for external beta radiation

    DEFF Research Database (Denmark)

    Christensen, P.; Bordy, J.M.; Ambrosi, P.


    was accomplished, This paper deals with the part of the performance test concerned with exposure to beta radiation. Fifteen dosimetric services participated with whole-body dosemeters intended to measure beta doses (H-p(0.07)) of which 13 used thermoluminescent (TL) detectors and two used photographic films. Eight......On the initiative of the European Dosimetry Group (EURADOS) action group 'Harmonisation and Dosimetric Quality Assurance in Individual Monitoring for External Radiation' a trial performance test for whole-body and extremity personal dosemeters broadly representative of those in use in the EU...... the results obtained from the exercise. In particular, based on the replies to a questionnaire issued to each participant, the results are analysed in relation to important design characteristics of the dosemeters taking part in the test....

  8. Independent evaluation of optically stimulated luminescence (OSL) 'dot' dosemeters for environmental monitoring. (United States)

    Timilsina, Bindu; Gesell, Thomas F


    Optically stimulated luminescence (OSL) 'dot' dosemeters (manufactured by Landauer®) are reported to have a high degree of environmental stability, high level of sensitivity and provide wide range of dose measuring capabilities from 0.05 mGy to 100 Gy. The optical read out method is fast and relatively simple and permits repeated read out, but few studies have been performed about its application in monitoring radiation in the environment. This study was initiated to independently test the performance of OSL dot dosemeters for the application of measuring doses of radiation in the outdoor environment. Testing was performed in the laboratory to evaluate reproducibility and stability and in the field to evaluate accuracy relative to calibrated high-pressure ionisation chambers. The results showed that OSL dot dosemeters had good reproducibility and stability in both laboratory and field tests and met the performance requirements of standards of the American National Standards Institute.

  9. Mixed field personnel dosimetry using a nearly tissue-equivalent multi-element thermoluminescence dosemeter

    Energy Technology Data Exchange (ETDEWEB)

    Moscovitch, M.; Velbeck, K.J.; Bencke, G.M. (Engelhard Corp., Harshaw Crystal and Electronic Products, Solon, OH (USA))


    The method of response interpretation for determining dose equivalents of a new multi-element thermoluminescence dosemeter in mixed photon-beta and photon-neutron fields is described. The four TL chips are LiF:Mg,Ti, each covered by its own unique filter. Experiments to determine the response of the dosemeter and to test the dose calculation algorithm were performed according to the standard established by the US Department of Energy Laboratory Accreditation Program (DOELAP). It has been shown that the dosemeter response can be used to identify the mixture type. The accuracy of the system has been proven in blind testing to be well within DOELAP tolerance limits in all test categories. (author).

  10. Theoretical study and calculation of the response of a fast neutron dosemeter based on track detection

    Energy Technology Data Exchange (ETDEWEB)

    Decossas, J.L.; Vareille, J.C.; Moliton, J.P.; Teyssier, J.L. (Limoges Univ., 87 (France). Lab. d' Electronique des Polymeres sous Faisceaux Ioniques)


    A fast neutron dosemeter is generally composed of a radiator in which n-p elastic scattering occurs and a detector which registers protons. A theoretical study, and the calculation (FORTRAN program) of the response of such a dosemeter is presented involving two steps: 1) The proton flux emerging from a thick radiator on which monoenergetic neutrons are normally incident is studied. This is characterised by its energy spectrum depending on the neutron energy and on the radiator thickness. 2) Proton detection being achieved with a solid state nuclear track detector whose performance is known, the number of registered tracks are calculated. The dosemeter sensitivity (tracks cm/sup -2/. Sv/sup -1/) is deduced. Then, the calculations show that it is possible to optimise the radiator thickness to obtain the smallest variation in sensitivity with neutron energy. The theoretical results are in good agreement with the experimental ones found in the literature.

  11. Elimination of Cerenkov interference in a fibre-optic-coupled radiation dosemeter. (United States)

    Justus, Brian L; Falkenstein, Paul; Huston, Alan L; Plazas, Maria C; Ning, Holly; Miller, Robert W


    An optical fibre point dosemeter based on the gated detection of the luminescence from a Cu(1+)-doped fused quartz detector effectively eliminated errors due to Cerenkov radiation and native fibre fluorescence. The gated optical fibre dosemeter overcomes serious problems faced by scintillation and optically stimulated luminescence approaches to optical fibre point dosimetry. The dosemeter was tested using an external beam radiotherapy machine that provided pulses of 6 MV X rays. Gated detection was used to discriminate the signal collected during the radiation pulses, which included contributions from Cerenkov radiation and native fibre fluorescence, from the signal collected between the radiation pulses, which contained only the long-lived luminescence from the Cu(1+)-doped fused quartz detector. Gated detection of the luminescence provided accurate, real-time dose measurements that were linear with absorbed dose, independent of dose rate and that were accurate for all field sizes studied.


    Sokolov, Alexey; Fehrenbacher, Georg; Radon, Torsten


    For the radiation survey at intermediate and high-energy accelerators, there is a need for a neutron dosemeter which provides reliable readings of the neutron dose in a wide energy range for continuous and pulsed radiation. The objective of this development is to find a dosemeter that fulfils the necessary requirements and can be reliably used to prove that the radiation levels in areas around accelerators are in accordance with the limits of the respective radiation protection legislation. A simple layout with small dimensions and light weight as well as the usage of common materials to lower the production costs is to be achieved.

  13. Testing the direct ion storage dosemeter for personal dosimetry in a nuclear research centre and a hospital. (United States)

    Vanhavere, F; Covens, P


    The direct ion storage (DIS) dosemeter can have some clear advantages in personal dosimetry. Before introducing the DIS into practice in the dosimetry service, a series of tests was performed on the linearity, angular and energy dependence, temperature influences and hard resets. After that, for several months, the DIS dosemeters were worn in parallel with the legal dosemeters (thermoluminescent badge) in a nuclear research centre and in several departments of a university hospital. The conclusions are that the DIS has good characteristics to be used as legal personal dosemeter, and that the comparison with the TLD badge is good. Only in interventional radiology and cardiology fields the DIS gives significant lower values than the TLD badge.


    Cardoso, J; Santos, L; Carvalhal, G; Oliveira, C


    The calibration of electronic personal dosemeters at the Portuguese ionizing radiation metrology laboratory uses the standard IEC 61526 for calibration methodology. This standard describes the irradiation geometry for testing and indicates that the standard ISO 4037-1, 2, 3 and 4 should be used. The ISO 4037 establishes that the reference point of test is a point in the radiation monitor, known or established, and the calibration phantom should be placed on its back in order to simulate the trunk body. Recently, ISO published another standard, the ISO 29661, that changes the reference point from the radiation monitor to the front face of the calibration phantom. The aim of this work is to present the result of the comparison of these two methodologies on personal dosemeters from five different manufacturers. The work shows differences in the Hp(10) response up to 4% resulting from the two different reference point concepts.

  15. Measurement models for passive dosemeters in view of uncertainty evaluation using the Monte Carlo method. (United States)

    van Dijk, J W E


    Two measurement models for passive dosemeters such as thermoluminescent dosemeter, optically stimulated luminescence, radio-photoluminescence, photographic film or track etch are discussed. The first model considers the dose evaluation with the reading equipment as a single measurement, the one-stage model. The second model considers the build-up of a latent signal or latent image in the detector during exposure and the evaluation using a reader system as two separate measurements, the two-stage model. It is discussed that the two-stage model better reflects the cause and effect relations and the course of events in the daily practice of a routine dosimetry service. The one-stage model will be non-linear in crucial input quantities which can give rise to erroneous behavior of the uncertainty evaluation based on the law of propagation of uncertainty. Input quantities that show an asymmetric probability distributions propagate through the one-stage model in a physically not relevant way.

  16. Application of TL dosemeters for dose distribution measurements at high temperatures in nuclear reactors. (United States)

    Osvay, M; Deme, S


    Al2O3:Mg,Y ceramic thermoluminescence dosemeters were developed at the Institute of Isotopes for high dose applications at room temperatures. The glow curve of Al2O3:Mg,Y exhibits two peaks--one at 250 degrees C (I) and another peak at approximately 400 degrees C (II). In order to extend the application of these dosemeters to high temperatures, the effect of irradiation temperature was investigated using temperature controlled heating system during high dose irradiation at various temperatures (20-100 degrees C). The new calibration and measuring method has been successfully applied for dose mapping within the hermetic zone of the Paks Nuclear Power Plant even at high temperature parts of blocks.

  17. ENEA extremity dosemeter based on LiF(Mg,Cu,P) to evaluate Hp(3,alpha). (United States)

    Mariotti, F; Fantuzzi, E; Morelli, B; Gualdrini, G; Botta, M C; Uleri, G; Bordy, J M; Denoziere, M


    Recent epidemiological studies suggest a rather low-dose threshold (ORAMED) Project, whose WP2 is aimed at the quantity H(p)(3) and eye lens dosimetry in practice, are taken into account. The paper summarises the main aspects of the study carried out at ENEA-Radiation Protection Institute (Bologna, Italy) to provide practical solutions (in the use and the design) to evaluate the response of the ENEA TL extremity dosemeter in terms of H(p)(3).


    Silva, E H; Knežević, Ž; Struelens, L; Covens, P; Ueno, S; Vanhavere, F; Buls, N


    Recent studies demonstrated that lens opacities can occur at lower radiation doses than previously accepted. In view of these studies, the International Commission of Radiological Protection recommended in 2011 to reduce the eye lens dose limit from 150 mSv/y to 20 mSv/y. This implies in the need of monitoring doses received by the eye lenses. In this study, small rod radiophotoluminescent glass dosemeters (GD-300 series; AGC, Japan) were characterized in terms of their energy (ISO 4037 X-rays narrow spectrum series, S-Cs and S-Co) and angular dependence (0  up to 90 degrees, with 2 ISO energies: N-60 and S-Cs). All acquisitions were performed at SCK•CEN-Belgium, using the ORAMED proposed cylindrical phantom. For selected energies (N-60, N-80, N-100, N-120 and N-250), the response of dosemeters irradiated on the ISO water slab phantom, at the Ruđer Bošković Institute-Croatia, was compared to those irradiated on the cylindrical phantom. GD-300 series showed good energy dependence, relative to S-Cs, on the cylindrical phantom. From 0 up to 45 degrees, the dosemeters showed no significant angular dependence, regardless whether they were tested when placed vertically or horizontally on the cylindrical phantom. However, at higher angles, some angular dependence was observed, mainly when the dosemeters were irradiated with low-energy photons (N-60). Results showed that GD-300 series have good properties related to Hp(3), although some improvements may be necessary.

  19. Individual monitoring in nuclear medicine therapeutic procedures using extremity dosemeters LiF(Mg, Cu, P). (United States)

    Sarti, G; Del Dottore, F; Fabbri, C; Tassinari, L; Pagan, S; Rustignoli, M; Motta, P


    Unsealed beta-gamma-emitting sources are used (15 GBq (90)Y each session) in nuclear medicine therapeutic procedures. Inside the manipulation cell and while giving the injection to the patient, the skin exposure is very high; electron radiation field is not homogeneous and thus the exposure of the extremities is not uniform. Particular individual monitoring is adopted: single thermoluminescence dosemeter, wrapped in polyethylene film and placed on an adhesive tape, is positioned on the tip of the fingers; 6-10 dosemeters are assigned to each operator per session. The energy and angle response is studied for X-ray spectra, (90)Sr/Y and (204)Tl--a unique mean calibration factor is calculated in order to estimate H(p)(0.07). Performance of dosemeter is analysed according to ISO 62387-1(2007) and the combined uncertainty (calculated using the Monte Carlo method) results lie in the order of 11 %. This method reveals the critical step of manipulation and administration and ensures that dose limits are not exceeded.

  20. The 12B counter: an active dosemeter for high-energy neutrons. (United States)

    Leuschner, A


    High-energy accelerators can produce strong time-structured radiation fields. Such dose shots are generated at linear machines with low duty cycles as well as at circular machines when complete fills are instantaneously lost. The main dose component behind thick shielding is due to high-energy neutrons occurring at that time structure. Dosemeters based on Geiger-Mueller tubes or proportional counters fail here completely. The 12B counter, a novel dosemeter made of a plastic scintillator using carbon activation for event-like exposure, has been introduced. High-energy neutrons activate the carbon nuclei by three inelastic reactions. The decay patterns with half-lives between 20 ms and 20 min can be exploited depending on the time structure of the radiation field. The response of the 12B counter was measured along with some other dosemeters, both active and passive, in the radiation field behind the lateral concrete shielding of a 7.5 GeV proton transfer line.

  1. Effective dose assessment in the maxillofacial region using thermoluminescent (TLD) and metal oxide semiconductor field-effect transistor (MOSFET) dosemeters: a comparative study

    NARCIS (Netherlands)

    Koivisto, J.; Schulze, D.; Wolff, J.; Rottke, D.


    Objectives: The objective of this study was to compare the performance of metal oxide semiconductor field-effect transistor (MOSFET) technology dosemeters with thermoluminescent dosemeters (TLDs) (TLD 100; Thermo Fisher Scientific, Waltham, MA) in the maxillofacial area. Methods: Organ and effective


    Directory of Open Access Journals (Sweden)

    E. N. Sheleenkova


    Full Text Available The article gives a comparative analysis of existing and newly developed thermoluminescent detectors DTG-4, TTLD-580, TLD-1011(TM and DTVS-01 and dosemeters MKD-A and MKD-B for the purposes of individual dosimetric control of skin and eye lens exposure to radiation. The dependence of sensitivity of different thermoluminescent dosemeters, designed for dose equivalents measurements in skin and eye lens on the type (photons and ȕ-particles and energy of radiation was determined experimentally. There are conclusions about the limits of applicability of existing detectors and dosemeters under different radiation exposure conditions. The article evaluates the possibility of different dosimeter use for specific radiation exposure conditions.

  3. Response of neutron dosemeters in radiation protection environments: an investigation of techniques to improve estimates of dose equivalent

    Energy Technology Data Exchange (ETDEWEB)

    Naismith, O.F.; Thomas, D.J. [National Physical Lab., Teddington (United Kingdom); Siebert, B.R.L. [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany)


    The response of practicable neutron dosemeters for routine use generally does not match the conversion function from fluence for radiation protection quantities such as the ambient dose equivalent. As a consequence, significant errors may be encountered when monitoring in a neutron energy spectrum different from that in which the dosemeter was calibrated, which is almost inevitably the case. A database of neutron energy spectra, detector response functions, and dosimetric conversion factors has been developed, and has been used to investigate the extent of this problem. The paper examines various ways of improving dosemeter response by `ranking` spectra and deriving correction factors based upon this ordering. In the case of area monitoring, a combination of two responses (e.g. a rem meter and TEPC) may serve to improve the measurement of dose equivalent. (author).

  4. Time-Dependent and Light-Induced Fading in Victoreen Model 2600-80 Aluminum Oxide Thermoluminescence Dosemeters (United States)


    2600-80 Aluminium Oxide Thermoluminescence Dosemeters ":"TIC,7 • :+ " 7-t-•CTE S , E 1P 1993 F’ t LEA l E J. H. Musk AFRRI TR93-6 Cleared for Public...SUBTITLE 5. FUNDING NUMBERS Time-Dependent and Light-Induced Fading in Victoreen0 Model 2600-80 Aluminium Oxide Thermoluminescence PE: QAXM...MODEL 2600-80 ALUMINIUM OXIDE THERMOLUMINESCENCE DOSEMETERS J. H. Musk Accesion For NTIS CRA&I DTIC TAB U.,announced D Justification ........ -.. By

  5. Optical fibre dosemeter systems for clinical applications based on radioluminescence and optically stimulated luminescence from Al2O3:C

    DEFF Research Database (Denmark)

    Marckmann, C.J.; Andersen, C.E.; Aznar, M.C.


    Optical fibre dosemeter systems based on radioluminescence and optically stimulated luminescence (OSL) from carbon-doped aluminium oxide (Al2O3:C) crystals were developed for in vivo real-time dose rate and absorbed dose measurements in radiotherapy and mammography. A technique was also developed...... for making ultra-small dosemeter probes that can easily be placed inside patients in radiation treatment. These probes have shown excellent properties in both head and neck intensity-modulated radiation therapy treatment and in mammography. The dose-response of the OSL signal for the new optical fibre...

  6. Development of advanced-type multi-functional electronic personal dosemeter. (United States)

    Nunomiya, T; Abe, S; Aoyama, K; Nakamura, T


    An advanced-type small, light, multi-functional electronic personal dosemeter has been developed using silicon semiconductor radiation detectors for dose management of workers at nuclear power plants and accelerator facilities. This dosemeter is 62 x 82 x 27 mm(3) in size and approximately 130 g in weight, which is capable of measuring personal gamma ray and neutron dose equivalents, Hp(10), simultaneously. The neutron dose equivalent can be obtained using two types of silicon semiconductors: a slow-neutron sensor (1 MeV). The slow neutron sensor is a 10 x 10 mm(2) p-type silicon on which a natural boron layer is deposited around an aluminium electrode. The fast neutron sensor is also a 10 x 10 mm(2) p-type silicon crystal on which an amorphous silicon hydride is deposited. The neutron energy response corresponding to the fluence-to-dose-equivalent conversion coefficient given by ICRP Publication 74 has been evaluated using a monoenergetic neutron source from 250 keV to 15 MeV at the Fast Neutron Laboratory of Tohoku University. As the result, the Hp(10) response to neutrons in the energy range of 250 keV and 4.4 MeV within +/-50% difference has been obtained.

  7. In-vivo dosimetry in radiotherapy: a comparison of the response of semiconductor and thermoluminescence (TLD700) dosemeters

    Energy Technology Data Exchange (ETDEWEB)

    Vynckier, S. [Universite Catholique de Louvain, Brussels (Belgium). Cliniques Universitaires St. Luc; Greffe, J.L.; Loncol, T.; Vanneste, F.; Octave-Prignot, M.; Denis, J.M.; De Patoul, N.


    Semiconductor dosemeters and thermoluminescence dosemeters were calibrated in view of in-vivo dosimetry. Their response in a 8 MV photon beam and the respective correction factors for the treatment conditions were systematically studied. A total of 249 entrance and exit measurements with this dual detector combination were performed, mainly for treatments of the head and neck region. The resulting entrance and exit doses were compared with the expected doses at these positions, calculated on basis of the treatment and patient parameters. The results at the entrance showed a value of 1.010 (2.8% for the ratio of the measured to the calculated dose by diodes, 1.013) 4.9% for the ratio of the measured to the calculated dose by TLD and 1.003 (3.6% for the ratio of the measured dose by TLD to diodes. With respect the exit dose, the results were 0.998) 4.9%, 1.016 (7.7% and 1.019) 7.0% respectively after correction for the heterogeneity`s. Although the standard deviation for the TLD dosemeters is systematically larger than the standard deviation for the diodes, it is concluded that both dosemeters will yield similar results for-in-vivo dosimetry, if utilized under the same conditions.

  8. Viability of the Fricke dosemeter doped with methylene blue; Viabilidade do dosimetro Fricke dopado com azul de metileno

    Energy Technology Data Exchange (ETDEWEB)

    Souza, V.L.B.; Santos, C.D.A.; Rodrigues, K.R.G.; Cunha, M.S.; Figueiredo, M.D.C.; Melo, R.T. [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)


    This work aims to find the possible utilization of the Fricke dosemeter doped with methylene blue (FMB) for the dosimetry of photodynamic therapy. The FMB was irradiated wit X rays and light emitted diodes demonstrating positive answers to the stimulus, being probably to be used for dosimetric objectives


    Rizk, C; Vanhavere, F


    The personal dosimetry service at the Lebanese Atomic Energy Commission uses Harshaw 8814 cards with LiF:Mg,Ti detectors. The dosemeters are read in a Harshaw 6600 TLD reader. In the process of accreditation for the ISO 17025 standard((1)), different influence factors are investigated and the uncertainty has been determined. The Individual Monitoring Service Laboratory-LAEC reads the dosemeters once it receives them from the customer, and new cards are immediately given for the next wearing period. The wearing period is 2 months. The dosemeter results are reported to the customers without background subtraction. Both Hp(10) and Hp(0.07) are reported. For this paper, only the uncertainty on Hp(10) will be focussed. The following factors are taken into account for the uncertainty: calibration factor, dosemeter homogeneity and repeatability, energy and angular dependence, non-linearity, temperature dependence, etc. Also the detection limit was determined. One of the important factors is the correction for fading. This fading correction depends on the procedure used such as storage temperatures, the time-temperature profile of the read-out, pre-heat and annealing conditions. Pre- and post-irradiation fading curves were measured for a storage period up to 182 d at room temperature (15-25°C). The resulting final combined standard uncertainty on the reported doses is of the order of 24 % for doses of ∼1 mSv.

  10. MCNP simulation of the incident and Albedo neutron response of the IRD Albedo Neutron Dosemeter for {sup 241}Am-Be moderated sources

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Bruno M.; Martins, Marcelo M.; Mauricio, Claudia L.P.; Mauricio, Claudia L.P. da, E-mail: [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Silva, Ademir X. [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear


    The IRD TLD Albedo dosemeter measures both incident and albedo neutron component. The incident to Albedo ratio is used to take into account the energy dependence of its response. In this paper, the behavior of the IRD Albedo dosemeter response as a function of the incident to Albedo ratio for {sup 241}Am-Be sources was simulated to improve its algorithm. The simulation was performed in MCNPX transport code and presents a good agreement with experimental measurements. The results obtained in this work are very useful to improve the accuracy of the IRD Albedo dosemeter at real neutron workplace. (author)

  11. Performance of Panasonic ZP-1460 Electronic Personal Dosemeter under Exposure Conditions Likely to be Found at Fukushima Daiichi Nuclear Power Plant (United States)

    Tsujimura, Norio; Yoshida, Tadayoshi; Hoshi, Katsuya; Momose, Takumaro

    A study on the performance of the Panasonic ZP-1460 electronic personal dosemeter, the model used in the aftermath of the Fukushima Daiichi nuclear power plant accident in March 2011, was conducted under actual exposure situations likely encountered in the plant. The tests pertained to (1) the dose rate response over dose rates >100 mSv/h and (2) the angular response on an anthropomorphic phantom exposed to the rotational and isotropic irradiation geometries. The test results confirmed that the dosemeter provides Hp(10) as a reasonably close estimate of the effective dose for any exposure geometries. The dosemeter response data evaluated in this study can be utilized for converting dosemeter readings to the absorbed dose to any organs and tissues for epidemiologic purposes.

  12. Ten years of personnel neutron dosimetry with Albedo dosemeters in the Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Draaisma, F.S.; Verhagen, H.W


    Since 1987, the dosimetry service of the Netherlands Energy Research Foundation has been certified by the Dutch government to perform personal dosimetry, using thermoluminescence dosemeters (TLDs). Performing neutron personal dosimetry requires a rather large investment in readers, TLDs and personnel to operate the service. About 800 persons are subjected to routine neutron monitoring in the Netherlands and their annual neutron doses are a relatively small fraction (less than 10%) of the annual H{sub p}(10). In general, the measured neutron dose values are low (on average 93% of the users receive an annual neutron dose <0.2 mSv). The collective annual (neutron) dose has tended to decrease since 1992, but incidentally high doses have been observed. Leaving these incidents out, the average collective annual neutron doses for the different users of neutron sources are about the same. (author)

  13. Performance of the EPD-N2 dosemeter for monitoring aircrew doses. (United States)

    Scherpelz, R I; Cezeaux, J R


    United States Air Force (USAF) aircrew fly at altitudes and for durations where doses from cosmic radiation are significant enough to warrant monitoring. This study evaluated a candidate radiological monitoring system for USAF aircrew, the Thermo Scientific electronic personnel dosemeter (EPD-N2). The evaluation consisted of characterising the device in a well-characterised radiation field at a European Organization for Nuclear Research (CERN) accelerator, and aboard an USAF aircraft. The performance of the EPDs was evaluated by comparison with accepted values for dose at the CERN facility, comparison with the value calculated by flight dose software and comparison with the value estimated by a tissue-equivalent proportional counter aboard the aircraft. This study recommends that a correction factor of 1/CF = 1/3.9 be applied to EPD-N2 measurements aboard aircraft flights. The uncertainty in this correction factor is 11.8 %.

  14. Measurement analysis using the Fricke dosemeter; Analise de medicoes com o dosimetro Fricke

    Energy Technology Data Exchange (ETDEWEB)

    Pedrosa, G.A.C. [Instituto Nacional de Metrologia (INMETRO), Rio de Janeiro, RJ (Brazil)], e-mail:; Dantas, C.C. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear], e-mail:; Campos, C.A. [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)], e-mail:


    The Fricke dosemeter has been used for absolute determination of the radiation dose between 40 and 350 Gy for X-rays, Gamma rays and fast electrons energies. The great inconvenient of that dosimetric system is the impossibility of using for measurements of exposure or low dose rates. A Fricke dosimetry system was implanted at the Nuclear Sciences Regional Center (CRCN), in Recife, Pernambuco state, Brazil, for the determination of radiation doses for spectrometry and mass dosimetry with plasma source. The statistical analysis of the obtained results have shown that using the spectrometric method that system cna be used for maintenance of factors of CRCN standard calibrations and the dose assessment thru mail system of radiotherapy centers of the country.


    Cardoso, J; Santos, J A M; Santos, L; Alves, J G; Oliveira, C


    The active personal dosemeter, RaySafe i2, allows the measurement and record of Hp(10) in real time, every second, via wireless technology for real-time display on a portable computer and/or a local network. The system seems particularly attractive for individual monitoring at clinical facilities where high intensity and varying radiation fields may occur, as it enables the user to acknowledge and optimize the dose and dose rate values in real time for each procedure. Prior to its use, the system was characterized at the Metrology Laboratory of Ionizing Radiation of IST-LPSR aiming at the metrological characterization of the system in accordance with IEC 61526:2010 for metrological control purposes and to verify the technical specifications stated by the manufacturer.

  16. Thermoluminescent dosemeter in a X-ray diffractometer; Dosimetria termoluminiscente en un difractometro de rayos X

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza A, D.; Gonzalez M, P.; Falcon B, T. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, Mexico D.F. (Mexico); Castano, V.M. [Instituto de Fisica, UNAM, Laboratorio Juriquilla, A.P. 1-1010, C.P. 76001, Queretaro (Mexico)


    In this work it was presented the results obtained of the dosimetry which was realized in a X-ray diffractometer for powders, trademark Siemens D5000, using the thermoluminescent signal generated by the X-rays in the commercial dosemeter TLD-100 of Harshaw, US. In according to the results obtained, the radiation quantity received by an analysed material in the diffractometer, will be proportional to exposure time and it can vary from unities until tenths of grays. These results are very outstanding when are analysed crystalline materials in a diffractometer, for knowing the present crystalline phases, mainly if these are highly sensitive to the ionizing radiation, as it is the case of the thermoluminescent materials. (Author)

  17. Determination of isodose curves in Radiotherapy using an Alanine/ESR dosemeter; Determinacion de curvas de isodosis en Radioterapia usando un dosimetro de Alanina/ESR

    Energy Technology Data Exchange (ETDEWEB)

    Chen, F.; Baffa, O.; Graeff, C.F.O. [Departamento de Fisica e Matematica. Universidade de Sao Paulo FFCLRP. 14040-901 Ribeirao Preto-SP (Brazil)


    It was studied the possible use of an Alanine/ESR dosemeter in the isodose curves mapping in normal treatments of Radiotherapy. It was manufactured a lot of 150 dosemeters with base in a mixture of D-L Alanine dust (80 %) and paraffin (20 %). Each dosemeter has 4.7 mm diameter and 12 mm length. A group of 100 dosemeters of the lot were arranged inside 50 holes of the slice 25 of the phantom Rando Man. The phantom irradiation was realized in two opposed projections (AP and PA) in Co-60 equipment. A group of 15 dosemeters was take of the same lot for obtaining the calibration curve in a 1-20 Gy range. After irradiation the signal of each dosemeter was measured in an ESR spectrometer operating in the X-band ({approx} 9.5 GHz) and the wideness of Alanine ESR spectra central line was correlated with the radiation dose. The wideness dose calibration curve resulted linear with a correlation coefficient 0.9996. The isodose curves obtained show a profile enough similar at comparing with the theoretical curves. (Author)

  18. Study of a selection of 10 historical types of dosemeter: variation of the response to Hp(10) with photon energy and geometry of exposure. (United States)

    Thierry-Chef, I; Pernicka, F; Marshall, M; Cardis, E; Andreo, P


    An international collaborative study of cancer risk among workers in the nuclear industry is tinder way to estimate direetly the cancer risk following protracted low-dose exposure to ionising radiation. An essential aspect of this study is the characterisation and quantification of errors in available dose estimates. One major source of errors is dosemeter response in workplace exposure conditions. Little information is available on energy and geometry response for most of the 124 different dosemeters used historically in participating facilities. Experiments were therefore set up to assess this. using 10 dosemeter types representative of those used over time. Results show that the largest errors were associated with the response of early dosemeters to low-energy photon radiation. Good response was found with modern dosemeters. even at low energy. These results are being used to estimate errors in the response for each dosemeter type, used in the participating facilities, so that these can be taken into account in the estimates of cancer risk.

  19. Comparison of neutron dose quantities and instrument and dosemeter readings at representative locations in an MOX fuel fabrication plant

    CERN Document Server

    Bartlett, D T; Tanner, R J; Haley, R M; Cooper, A J


    The relationships between operational and protection quantities, and values of personal dosemeter and instrument readings have been determined for a recently designed MOX fuel fabrication plant. The relationships between the quantities, and the readings of personal dosemeters are sensitive to both the energy and direction distribution of neutron fluence. The energy distributions were calculated using the Monte Carlo code MCBEND. The direction distribution was addressed by calculating independently, spectral components for which the direction distribution could be reasonably assumed. At representative locations, and for assumed worker orientations, the radiation field is analysed as having, in general, three components--a direct, unidirectional component from the nearest identified discrete source, which is considered incident A-P, several unidirectional components from other such sources which are treated as a rotational component and a scattered isotropic component. The calculated spectra were folded with co...

  20. Measurement of staff doses in interventional procedures using LiF TL-detectors and a special diode dosemeter

    Energy Technology Data Exchange (ETDEWEB)

    Parviainen, T.; Toivonen, M.; Kosunen, A.; Karppinen, J. [Radiation and Nuclear Safety Authority, Helsinki (Finland); Ylitalo, A. [Satakunta Central Hospital, Division for Cardiology, Pori (Finland)


    Personal doses vary considerably among the operational staff in cardiac examination procedures and interventions. Correspondingly, the fluoroscopy time may vary from a few minutes to more than 1 hour. Large personal doses in the range of 35 - 41 mSv were registered to some interventional radiologists and cardiologists in 2001 in Finland. Measurement of doses per intervention from hands, shoulders and ankles (parts of the body outside the lead apron) are therefore of interest, but small and highly sensitive dosemeters have not been commonly available for reliable and practical measurements. Thermoluminescent detectors of LiF:MgCu,P are sensitive enough, but residual luminescence from previous uses of detectors and the dose collected from natural background radiation between preparation for use and readout may be significant sources of uncertainty. The company Unfors Instrumens AB (Billdal, Sweden) has designed a light weight diode dosemeter with long cables between detectors and the electronic part for simultaneous measurement of doses from various parts of the body. The aim of this work is to report doses of the operating staff per a cardiac examination or intervention and study the capabilities of the diode dosemeter in staff dose measurements. (orig.)

  1. Selection of the most appropriate two-dosemeter algorithm for estimating effective dose equivalent during maintenance periods in Korean nuclear power plants. (United States)

    Kim, Hee Geun; Kong, Tae Young


    The application of a two-dosemeter system with its algorithm, as well as a test of its use in an inhomogeneous high-radiation field, is described in this study. The goal was to improve the method for estimating the effective dose equivalent during maintenance periods at Korean Nuclear Power Plants (NPPs). The use of this method in Korean and international NPPs, including those NPPs in the USA and Canada, was also investigated. The algorithms used by the the American National Standards Institute, Lakshmanan, the National Council on Radiation Protection and Measurements (NCRP), the Electric Power Research Institute and Kim were extensively analysed as two-dosemeter algorithms. Their possible application to NPPs was evaluated using data for each algorithm from two-dosemeter results that were obtained from an inhomogeneous high-radiation field during maintenance periods at Korean NPPs. The NCRP algorithm (55:50) was selected as an optimal two-dosemeter algorithm for Korean NPPs by taking into account the field test results and the convenience of wearing two dosemeters.

  2. Active personal dosemeters in interventional radiology: tests in laboratory conditions and in hospitals. (United States)

    Clairand, I; Bordy, J-M; Daures, J; Debroas, J; Denozière, M; Donadille, L; Ginjaume, M; Itié, C; Koukorava, C; Krim, S; Lebacq, A-L; Martin, P; Struelens, L; Sans-Mercé, M; Tosic, M; Vanhavere, F


    The work package 3 of the ORAMED project, Collaborative Project (2008-11) supported by the European Commission within its seventh Framework Programme, is focused on the optimisation of the use of active personal dosemeters (APDs) in interventional radiology and cardiology (IR/IC). Indeed, a lack of appropriate APD devices is identified for these specific fields. Few devices can detect low-energy X rays (20-100 keV), and none of them are specifically designed for working in pulsed radiation fields. The work presented in this paper consists in studying the behaviour of some selected APDs deemed suitable for application in IR/IC. For this purpose, measurements under laboratory conditions, both with continuous and pulsed X-ray beams, and tests in real conditions on site in different European hospitals were performed. This study highlights the limitations of APDs for this application and the need of improving the APD technology so as to fulfil all needs in the IR/IC field.

  3. Study on the response of thermoluminescent dosemeters to synchrotron radiation: experimental method and Monte Carlo calculations. (United States)

    Bakshi, A K; Chatterjee, S; Palani Selvam, T; Dhabekar, B S


    In the present study, the energy dependence of response of some popular thermoluminescent dosemeters (TLDs) have been investigated such as LiF:Mg,Ti, LiF:Mg,Cu,P and CaSO(4):Dy to synchrotron radiation in the energy range of 10-34 keV. The study utilised experimental, Monte Carlo and analytical methods. The Monte Carlo calculations were based on the EGSnrc and FLUKA codes. The calculated energy response of all the TLDs using the EGSnrc and FLUKA codes shows excellent agreement with each other. The analytically calculated response shows good agreement with the Monte Carlo calculated response in the low-energy region. In the case of CaSO(4):Dy, the Monte Carlo-calculated energy response is smaller by a factor of 3 at all energies in comparison with the experimental response when polytetrafluoroethylene (PTFE) (75 % by wt) is included in the Monte Carlo calculations. When PTFE is ignored in the Monte Carlo calculations, the difference between the calculated and experimental response decreases (both responses are comparable >25 keV). For the LiF-based TLDs, the Monte Carlo-based response shows reasonable agreement with the experimental response.


    Figel, Markus; Stadtmann, Hannes; Grimbergen, Tom W M; McWhan, Andrew; Romero, Ana M


    Starting in 2008 the European Dosimetry Group (EURADOS) has been performing international intercomparisons on photon whole-body dosemeters for individual monitoring services. These intercomparisons were organised (on a biannual basis) in 2008, 2010, 2012 and 2014, each time with a similar set-up but with small alterations in the subsequent irradiation plans. With an increasing number of participants and participating systems, this intercomparison action has become an important tool for individual monitoring services to test their whole-body dosimetry systems, compare their results with other services or systems and to improve the quality of their dosimetry. The paper presents and compares the results of these four intercomparisons and compares the dosimetric results for the participating system types. Major dosimetric problems of the individual monitoring services are identified, and trends in the dosimetric performance of the different systems are shown. This gives the opportunity to identify some dosimetry issues that should be improved by application of the monitoring services' quality assurance systems and QA procedures.

  5. Biologic

    CERN Document Server

    Kauffman, L H


    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  6. Effect of the energy dependence of response of neutron personal dosemeters routinely used in the UK on the accuracy of dose estimation

    CERN Document Server

    Tanner, R J; Thomas, D J


    A large set of neutron energy distributions have been classified by workplace to provide a guide to the neutron fields to which workers in particular industries are likely to be exposed. These have been combined (folded) with the results of a major programme of neutron personal dosemeter response function measurements, to provide results for the systematic errors that those dosemeters would give in workplaces. Data for neutron doses recorded for UK classified workers have been taken from the CIDI tables, and related to the results from the folding process. It has hence been possible to draw conclusions about the probable systematic errors that result from the use of the currently available neutron personal dosemeters, which have inherent problems associated with their energy dependence of response.

  7. Study of teflon pads as high doses dosemeters; Estudo de pastilhas de teflon como dosimetros de doses altas

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Maria Ines; Caldas, Linda V.E., E-mail:, E-mail: [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)


    The aim of this work is to study the Teflon, which is used as a binder in the manufacture of dosimetric tablets, for the feasibility of this material as high dose dosemeter. In this paper we used the technique of thermally stimulated luminescence (OSL) to characterize the dosimetric properties of Teflon. Teflon samples were exposed to different doses of radiation, using a source of gamma radiation ({sup 60}Co). It was obtained dose-response curve between 100 Gy to 50 kGy and reproducibility of OSL response. The preliminary results show that Teflon is a useful material to high dose dosimetry.

  8. About the measurements systems with pen and thermoluminescent dosemeters; Sobre los sistemas de medicion con dosimetros de pluma y los termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Cortes I, M.E.; Ramirez G, F.P. [Instituto Mexicano del Petroleo, Eje Central Lazaro Cardenas 152. 07730 Mexico D.F. (Mexico)


    In this work it is presented dosimetric data obtained with pen and thermoluminescent dosemeters, which are used by the Occupational Exposure Personnel (OEP) of the Mexican Petroleum Institute (IMP)(1). It was marked several great characteristics as for example, the differences among units which use one and another dosemeter type. Likewise, it is given to know diverse problems that were had in the IMP at relating the data obtained with these dosemeters (which utilizes OEP) and the ICRP 60 recommendations 1990. One of the most important difficulties is to satisfy the recommended limits by ICRP, particularly those that are referring to the units and their complex calculations. With respect to the unities, the ICRP makes reference at the concepts `dose equivalent` and `effective dose` with the sievert unit, that the General Regulations for Radiological Safety associates with `dose equivalent` and `effective dose equivalent`. It was illustrated the type of dosimetric statistics which are obtained with the TLD lectures and a OEP pen dosemeter during 1997. (Author)

  9. TL response of LiF: Mg, Cu, P dosemeters in function of the photon energy; Respuesta TL de dosimetros de LiF: Mg, Cu, P en funcion de la energia del foton

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, P.R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Azorin, J. [UAM-I, 09340 Mexico D.F. (Mexico); Furetta, C. [Universita degli Studi di Roma ' La Sapienza' , Piazzale Aldo Moro 2, 00185 Roma (Italy)


    In this work the obtained results of studying the response of dosemeters of LiF: Mg, Cu, P + Ptfe, developed in the ININ, commercial dosemeters GR200A (LiF: Mg, Cu, P) of chinese manufacture and TLD-100 (LiF: Mg, Ti) US are presented, when irradiating them with X rays 16, 24, 34.5, 42, 100 and 145 keV of effective energy, with gamma rays of 662 keV ({sup 137} Cs) and 1252 keV ({sup 60} Co). The results are presented in function of the sensitivity that the dosemeters showed normalized to gamma radiation of {sup 60} Co. It was appreciated that the dosemeters more equivalent to the tissue, they were those of LiF: Mg, Cu, P + Ptfe, while the less equivalent ones were the TLD-100. (Author)

  10. Use of active dosemeters as a optimization tool in hemodynamics; Uso de dosimetros ativos como ferramenta de otimizacao em hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Rafael; Pereira, Dirceu D. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Inst. de Fisica; Canevaro, Lucia V. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Rodrigues, Barbara B.D. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Ferreira, Esmeralci [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Servico de Hemodinamica


    Interventional cardiology procedures are, in general, associated with high doses in patients and professionals. The objective of this study is to measure the radiation levels received by professionals .The professional dosimetry was performed in a department of Hemodynamics of University Hospital in Rio de Janeiro. were followed 331 coronary angiography (CA) and 26 percutaneous transluminal coronary angioplasty (PTCA) procedures. For this, were used active dosemeters to measure the radiation levels at the chest of interventional professionals. The results show that average personal equivalent dose of doctors, per procedure was 100 e 154 μSv. On average, nursing technicians and radiologist receive 12 and 10% of doses of physicians, respectively, during CA procedures. From the results, it appears that the doses of hemodynamics exceed the annual dose limit of the standards. The use of lead shielding is presented as an effective action to reduce doses in these workers. (author)

  11. Performance of the electronic personal dosemeter for neutron 'Saphydose-N' at different workplaces of nuclear facilities. (United States)

    Lahaye, T; Chau, Q; Ménard, S; Lacoste, V; Muller, H; Luszik-Bhadra, M; Reginatto, M; Bruguier, P


    This paper mainly aims at presenting the measurements and the results obtained with the electronic personal neutron dosemeter Saphydose-N at different facilities. Three campaigns were led in the frame of the European contract EVIDOS ('Evaluation of Individual Dosimetry in Mixed Neutron and Photon Radiation Fields'). The first one consisted in the measurements at the IRSN French research laboratory in reference neutron fields generated by a thermal facility (SIGMA), radionuclide ISO sources ((241)AmBe; (252)Cf; (252)Cf(D(2)O)\\Cd) and a realistic spectrum (CANEL/T400). The second one was performed at the Krümmel Nuclear Power Plant (Germany) close to the boiling water reactor and to a spent fuel transport cask. The third one was realised at Mol (Belgium), at the VENUS Research Reactor and at Belgonucléaire, a fuel processing factory.

  12. Absorbed dose measurements in mammography using Monte Carlo method and ZrO{sub 2}+PTFE dosemeters

    Energy Technology Data Exchange (ETDEWEB)

    Duran M, H. A.; Hernandez O, M. [Departamento de Investigacion en Polimeros y Materiales, Universidad de Sonora, Blvd. Luis Encinas y Rosales s/n, Col. Centro, 83190 Hermosillo, Sonora (Mexico); Salas L, M. A.; Hernandez D, V. M.; Vega C, H. R. [Unidad Academica de Estudios Nucleares, Universidad Autonoma de Zacatecas, Cipres 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Pinedo S, A.; Ventura M, J.; Chacon, F. [Hospital General de Zona No. 1, IMSS, Interior Alameda 45, 98000 Zacatecas (Mexico); Rivera M, T. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, IPN, Av. Legaria 694, Col. Irrigacion, 11500 Mexico D. F.(Mexico)], e-mail:


    Mammography test is a central tool for breast cancer diagnostic. In addition, programs are conducted periodically to detect the asymptomatic women in certain age groups; these programs have shown a reduction on breast cancer mortality. Early detection of breast cancer is achieved through a mammography, which contrasts the glandular and adipose tissue with a probable calcification. The parameters used for mammography are based on the thickness and density of the breast, their values depend on the voltage, current, focal spot and anode-filter combination. To achieve an image clear and a minimum dose must be chosen appropriate irradiation conditions. Risk associated with mammography should not be ignored. This study was performed in the General Hospital No. 1 IMSS in Zacatecas. Was used a glucose phantom and measured air Kerma at the entrance of the breast that was calculated using Monte Carlo methods and ZrO{sub 2}+PTFE thermoluminescent dosemeters, this calculation was completed with calculating the absorbed dose. (author)

  13. Use of a robotic manipulator in the simulation of the automation of a calibration process of dosemeters; Uso de un manipulador robotico en la simulacion de la automatizacion de un proceso de calibracion de dosimetros

    Energy Technology Data Exchange (ETDEWEB)

    Benitez R, J.S.; Najera H, M.C. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    The development of a system based in a manipulative robot which simulates the operative sequence in a calibration process of dosemeters is presented. In this process it is performed the monitoring of the dosemeter positions and the calibrator by mean of an arm of articulated robot which develops the movement sequences and the taking a decision based on the information coming from the external sensors. (Author)

  14. Methodology for Mixed Field Inhalation Dosimetry in Monazite Areas using a Twin-Cup Dosemeter with Three Track Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Mayya, Y.S.; Eappen, K.P.; Nambi, K.S.V


    A methodology is proposed for estimating the gas and potential alpha energy concentrations (PAECs), and inhalation dose rates due to a mixed field of radon, thoron and their progeny present in the indoor atmosphere, using a radon-thoron discriminating dosemeter having three solid state nuclear track detectors (SSNTDs). The gas concentrations present in the vicinity of the dosemeter are directly measured through SSNTDs exposed in the 'cup mode'. The bare track density rates are related to the gas and the progeny concentrations by incorporating ventilation rate dependent spatial profiles for thoron gas. The ventilation rate is extracted as a real positive root of the governing equation and from this, the PAECs as well as the inhalation dose rates are estimated through the use of standard formulae. Error estimates on the dose rates have been carried out. Analyses of the field data from a sample survey of 35 houses situated in monazite bearing high background radiation areas of Kerala indicate that the methodology works successfully in a majority of the cases. Results for 22 cases which showed less than 100% statistical error are presented. These show median values of about 4.8 Bq.m{sup -3} and 462 Bq.m{sup -3} for radon and room averaged thoron concentrations, 0.5 mWL and 129 mWL for radon progeny and thoron progeny PAECs, and 1.21 {mu}Sv.h{sup -1} for inhalation dose rate. Although a complete picture would emerge only at the end of the ongoing large scale survey, the sample survey already indicates that indoor thoron levels in the Kerala monazite area are the highest reported so far in the literature. (author)

  15. A fibre optic scintillator dosemeter for absorbed dose measurements of low-energy X-ray-emitting brachytherapy sources. (United States)

    Sliski, Alan; Soares, Christopher; Mitch, Michael G


    A newly developed dosemeter using a 0.5 mm diameter x 0.5 mm thick cylindrical plastic scintillator coupled to the end of a fibre optic cable is capable of measuring the absorbed dose rate in water around low-activity, low-energy X-ray emitters typically used in prostate brachytherapy. Recent tests of this dosemeter showed that it is possible to measure the dose rate as a function of distance in water from 2 to 30 mm of a (103)Pd source of air-kerma strength 3.4 U (1 U = 1 microGy m(2) h(-1)), or 97 MBq (2.6 mCi) apparent activity, with good signal-to-noise ratio. The signal-to-noise ratio is only dependent on the integration time and background subtraction. The detector volume is enclosed in optically opaque, nearly water-equivalent materials so that there is no polar response other than that due to the shape of the scintillator volume chosen, in this case cylindrical. The absorbed dose rate very close to commercial brachytherapy sources can be mapped in an automated water phantom, providing a 3-D dose distribution with sub-millimeter spatial resolution. The sensitive volume of the detector is 0.5 mm from the end of the optically opaque waterproof housing, enabling measurements at very close distances to sources. The sensitive detector electronics allow the measurement of very low dose rates, as exist at centimeter distances from these sources. The detector is also applicable to mapping dose distributions from more complex source geometries such as eye applicators for treating macular degeneration.

  16. Evaluation of neutron doses received at different organs in radiotherapy treatments using the UAB PADC based dosemeters in an anthropomorphic phantom

    Energy Technology Data Exchange (ETDEWEB)

    Domingo, C., E-mail: [Grup de Fisica de les Radiacions, Departament de Fisica, Edifici C, Universitat Autonoma de Barcelona, E-08193 Bellaterra (Spain); Garcia-Fuste, M.J.; Morales, E.; Amgarou, K.; Castelo, J. [Grup de Fisica de les Radiacions, Departament de Fisica, Edifici C, Universitat Autonoma de Barcelona, E-08193 Bellaterra (Spain); Sanchez-Doblado, F. [Hospital Universitario Virgen Macarena, Servicio de Radiofisica, Sevilla (Spain); Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad de Sevilla (Spain)


    The NEUTOR project was set up to study radiotherapy patient exposures to the neutrons produced around the LINAC accelerator head by photon radiation above approx8 MeV. These neutrons may reach the patient directly, or they may interact with the surrounding materials until they become thermalised, scattering all over the treatment room and affecting the patient as well. A miniaturised version of the UAB PADC based neutron dosemeter is used, together with thermoluminescence Li-6/Li-7 pairs, in several positions inside an anthropomorphic female phantom to determine doses received by the patient at several organs or tissues. Irradiations were made at a 15 MV LINAC (Hospital Universitario Virgen de la Macarena, Sevilla, Spain), an 18 MV LINAC (Hospital General Universitario de Valencia, Spain) and a 23 MV LINAC (Universitaetsklinikum Heidelberg, Germany). Preliminary patient dose maps obtained from the UAB PADC dosemeter measurements (considering an average calibration factor for all neutron energies) are reported in this work.

  17. Determination of the dose index in computerized tomography using thermoluminescent dosemeters; Determinacion del indice de dosis en tomografia computada usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Azorin, J.C.; Calderon, A. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-IPN, 11500 Mexico D.F. (Mexico); Azorin, J. [UAM-I, 09340 Mexico D.F. (Mexico)


    In this work the obtained results of the determination of the dose index are presented in thorax studies in computed tomography and helical tomography carried out in Mexico using thermoluminescent dosemeters of LiF: Mg,Cu,P + Ptfe developed and manufactured in our country. The results showed that under similar conditions of irradiation and operation (pitch = 1), significant differences don't exist among the doses absorbed measures in the phantom due to the two types of used tomographs. (Author)

  18. Tl response of LiF: Mg, Cu, P + PTFE (Mexico) and GR200A (China) dosemeters; Respuesta Tl de dosimetros de LiF: Mg, Cu, P + PTFE (Mexico) y GR200A (China)

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez M, P.R. [ININ, A.P. 18-1027, Mexico D.F. (Mexico); Azorin N, J.; Furetta, C. [UAM-I, 09340 Mexico D.F. (Mexico)


    TLD-100 was the commercial dosemeter more known since some decades ago. This dosemeter was considered for many research groups as the reference material for developing new Tl materials for ionizing radiation dosimetry. Actually it seems that TLD-100 is going to be replaced by the Chinese material GR200A, as reference material due that this material in addition to be considered as a tissue equivalent material, is 30 to 35 times more sensitive that TLD- 100. Results of the study of the Tl response of LiF: Mg, Cu, P + Ptfe developed at ININ-Mexico, comparing them with those of GR200A are presented. These results showed that the sensitivity (s = Tl intensity/weight x dose) to gamma radiation of the LiF: Mg, Cu, P + Ptfe dosimeters was 4.34 meanwhile that of the commercial dosemeter was 3.41. Detection threshold of the dosemeters studied was 2.22 and 0.52 {mu}Gy respectively Repeatability after 10 cycles Irradiation-reading-annealing was {+-}1.39% and {+-}1.86% respectively. Both types of dosemeters presented a linear response as a function of gamma radiation in the range from 0.02 mGy and 100 Gy. (Author)

  19. Measurement of doses to aviator pilots using thermoluminescent dosemeters; Medicion de la dosis a pilotos aviadores usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Azorin N, J.; Cruz C, D. [UAM-I, 09340 Mexico D.F. (Mexico); Rivera M, T. [IPN, ESIME Culhuacan (Mexico)]. e-mail:


    During the development of their work, the aviator pilots are exposed at high levels of natural radiation of bottom caused mainly by the cosmic radiation of galactic origin and lot. For such reason, the Metropolitan Autonomous University (UAM) and the Union Association of Aviator Pilots (ASPA), subscribed an agreement with the purpose of to measure the doses of ionizing radiation received by the aviator pilots of diverse air companies that man different types of airships and to determine if these doses surpass the one limit of 0.11 mSv/h settled down by the IAEA for the public in general; and if therefore, these workers should be considered as personnel occupationally exposed. In this work the obtained results when measuring the absorbed dose received by Mexican civil aviator pilots during the development of their work, using thermoluminescent dosemeters of LiF:Mg,Cu,P + Ptfe of national production are presented. The obtained results during the years of 2001 and 2002 show that the monthly doses received by the pilots surpass the one it limits established for the public in general, for what they should be considered as personnel occupationally exposed. (Author)

  20. The former tests realized to a personal neutron dosemeter based on solid nuclear tracks detector; Primeras pruebas realizadas a un dosimetro personal de neutrones basado en detectores solidos de trazas nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Camacho, M.E.; Tavera, L.; Balcazar, M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    Due to the increase in the use of neutron radiation a personal neutron dosemeter based on solid nuclear tracks detector (DSTN) was designed and constructed. The personal dosemeter design consists of three arrangements. The first one consists of a plastic nuclear tracks detector (LR115 or CR39) in contact with a LiF pellet. The second one is the same that above but it placed among two cadmium pellets and, the third one is formed by the alone detector without converter neither neutron absorber. The three arrangements are placed inside a plastic porta detector hermetically closed to avoid the bottom produced by environmental radon whichever both detectors (LR115 and CR39) are sensitive. In this work the former tests realized to that dosemeter are presented. (Author)

  1. Determination of the dose rapidity of a {sup 90} Sr beta radiation source using thermoluminescent dosemeters; Determinacion de la rapidez de dosis de una fuente de radiacion beta de {sup 90}Sr usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez M, P.R.; Azorin N, J.; Rivera M, T. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    The thermoluminescent dosemeters developed in Mexico, have been used efficiently in environmental and personal dosimetry. When the dose rate of some source is not known can be estimated with the use of thermoluminescent dosemeters taking in account the geometrical array used in the irradiations for reproducibility of the results in posterior irradiations. In this work it was estimated the dose rate of a {sup 90} Sr-{sup 90} Y beta radiation source which is property of the Nuclear Sciences Institute, UNAM, therefore it was l ended to the Metropolitan Autonomous University- Iztapalapa Unit for the characterization of new Tl materials, taking account of the institutional collaboration agreements. (Author)

  2. Energy and directional response for the Harshaw dosemeter holders 8814 and 8891, and its effect on the appropriate radiation qualities for absolute calibration. (United States)

    Børretzen, I; Wøhni, T


    The personal dosimetry laboratory at the Norwegian radiation protection authority utilises a two-element dosemeter card for measuring Hp(10) and Hp(0.07), in a Harshaw dosemeter holder type 8814. Energy and directional responses for photons and betas for this holder have been assessed, as well as for the new Harshaw holder type 8891. The energy response characteristics for the 12-1250 keV photon energy range, in terms of TL output per unit Hp(10) and Hp(0.07) have been evaluated. The maximum over-response to under-response ratio for the Hp(10) element was found to be 1.46 for the new type 8891 holder, as compared to 1.55 for the older type 8814. The new holder also displays a more favourable directional response for this element. For the Hp(0.07) element, no significant differences with regard to energy or directional responses were found. Selecting radiation energy for absolute calibration of the Hp(10) and Hp(0.07) elements are discussed.

  3. Energy and directional response for the Harshaw dosemeter holders 8814 and 8891, and its effect on the appropriate radiation qualities for absolute calibration

    Energy Technology Data Exchange (ETDEWEB)

    Borretzen, I.; Wohni, T


    The personal dosimetry laboratory at the Norwegian radiation protection authority utilises a two-element dosemeter card for measuring H{sub p}(10) and H{sub p}(0.07), in a Harshaw dosemeter holder type 8814. Energy and directional responses for photons and betas for this holder have been assessed, as well as for the new Harshaw holder type 8891. The energy response characteristics for the 12-1250 keV photon energy range, in terms of TL output per unit H{sub p}(10) and H{sub p}(0.07) have been evaluated. The maximum over-response to under-response ratio for the H{sub p}(10) element was found to be 1.46 for the new type 8891 holder, as compared to 1.55 for the older type 8814. The new holder also displays a more favourable directional response for this element. For the H{sub p}(0.07) element, no significant differences with regard to energy or directional responses were found. Selecting radiation energy for absolute calibration of the H{sub p}(10) and H{sub p}(0.07) elements are discussed. (author)

  4. Effect of some parameters in the response of the Perspex 3042, Lot L amber dosemeters; Efectos de algunos parametros en la respuesta de los dosimetros ambar Perspex 3042, Lote L

    Energy Technology Data Exchange (ETDEWEB)

    Prieto M, E.F.; Barrera G, G. [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN). Calle 30, No. 502, esq. 5ta. Avenida, Playa, Ciudad de La Habana (Cuba)]. e-mail:


    The answer of the dosimetric systems is affected by several factors, for what should know as these factors they influence in each one of the different dosimetric systems and by this way to minimize its effect in the value of the absorbed dose and to obtain exact dose values. One of the dosimetric systems more used in the high dose dosimetry like routine dosemeter for the control of the irradiation process are the Perspex dosemeters, for their speed in the obtaining the information, their easy manipulation and the precision that they present. To this dosemeters group they belong the same as the Red and Clear the Amber, which are adequate for the measurement of the radiation dose in the range of high doses. The objective of the present work is to obtain the calibration curves of the dosemeters Amber Perspex 3042, Lot L under our work conditions, like they are the irradiation temperatures and of storage and to know the influence of the rate dose in the value of the absorbed dose for different measurement wavelengths, as well as, the relationship among the one post-irradiation time and the specific absorbance value induced in function of the absorbed dose. (Author)

  5. Study on routines and procedures of calibration of clinical dosemeter on gamma radiation beams at the IPEN-CNEN/SP, Brazil; Estudo das rotinas e procedimentos de calibracao de dosimetros clinicos em feixes de radiacao gama no IPEN-CNEN/SP

    Energy Technology Data Exchange (ETDEWEB)

    Damatto, Willian B.; Potiens, Maria da Penha A.; Santos, Gelson P.; Vivolo, Vitor, E-mail: wbdamatto@ipen.b, E-mail: mppalbu@ipen.b, E-mail: gpsantos@ipen.b, E-mail: vivolo@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)


    The calibration consists in the comparison of the equipment to be calibrated with other equipment already calibrated by another standard, which means the equipment that will accomplish shall be considered secondary or tertiary, depending on the calibration that will be accomplished. As the clinical dosemeters are used for quality control services in the hospitals, these dosemeters need a reliable measurement precision. Therefore, this work intends to demonstrate the importance of the clinical dosemeter and the calibration, requiring special care face to all clinical set

  6. Exposure levels to radiation in a nuclear medicine laboratory: measurements with thermoluminescence dosemeters; Niveles de exposicion a la radiacion en un laboratorio de medicina nuclear: mediciones con dosimetros de termoluminiscencia

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz J, A. [Departamento de Medicina Nuclear del Instituto nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico D.F. (Mexico)


    Since 1996 in the Nuclear medicine Department and another routine and research departments of the National Institute of Medical and Nutrition Sciences (INCMNSZ) are working at least with 12 radioactive sources opened and sealed. However, it was unknown if with the Tl personal dosemeters with lithium fluoride crystals (LiF), could be possible to receive information about the equivalent dose for each radionuclide or if there was some radionuclide that by being low energy emissor or beta energy emissor, it did not represent an ionization power sufficient to excite the crystals of the thermoluminescent dosemeters (DTL). In this work the obtained results with control dosemeters of diverse source opened or sealed are shown, which were put at 1 cm of the LiF crystals during a time exposure 18 hours. Therefore the objective of this work is to verify which sources excite or not to DTL crystals and taking the pertinent safety measures for each radionuclide. The conclusion is that the majority of dosemeters were excited by beta or gamma radiation of the radionuclides and that LiF crystals are able to receive equivalent doses until 1200 mSv, being this a guarantee for the staff, that in an any moment could be exposed to high dose in his working day. Also it was corroborated that the radionuclides more energizer are: iodine-131, iodine-125 and sodium-22 while the phosphorus-32 must be managed with careful, since the exposure to hands can result significant, just like the technetium-99m ({sup 99m} Tc). (Author)

  7. New ICRU quantities for the environmental and individual monitoring. Standardization of individual dosemeters by using external beams of photon radiation; Nuevas magnitudes ICRU para la vigilancia radiologica ambiental e individual. Calibracion de dosimetros personales usando haces externos de fotones

    Energy Technology Data Exchange (ETDEWEB)

    Brosed, A.; Delgado, A.; Granados, C. E.


    The quantities introduced by ICRU for the radiological monitoring are commented, specially those implied in individual protection against external photons. A procedure is proposed in order to standardize the individual dosemeters by using the kerma in air references of CIEMAT-JEN. The reference radiation beams are described in connection with ISO standards. Provisional values are selected for the appropriate conversion and correction factors. (Author) 23 refs.

  8. Relative thermoluminescent efficiencies proton/gamma and helium/gamma of high temperature peaks in TLD-100 dosemeters; Eficiencias termoluminiscentes relativas proton/gamma y helio/gamma de picos de alta temperatura en dosimetros TLD-100

    Energy Technology Data Exchange (ETDEWEB)

    Flores M, E.; Avila, O.; Rodriguez V, M. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico); Massillon, J.L.G.; Buenfil A, E.; Ruiz T, C.; Brandan, M.E. [IFUNAM, 04500 Mexico D.F. (Mexico); Gamboa De Buen, I. [ICN-UNAM, 04500 Mexico D.F. (Mexico)


    This work presents measures of relative thermoluminescent efficiency of those high temperature peaks of TLD-100 dosemeters exposed to protons of 1.5 MeV and to helium nuclei of 3 and 7.5 MeV. A rigorous reading and of deconvolution protocol was used for the calculation of the TL efficiencies. Additionally an Excel program that facilitated the deconvolution adjustment process of the glow curves was elaborated. (Author)

  9. Thermoluminescent response of dosemeters TLD-100 exposed to distinct baker protocols, irradiation and reading; Respuesta termoluminiscente de dosimetros TLD-100 sujetos a distintos protocolos de horneado, irradiacion y lectura

    Energy Technology Data Exchange (ETDEWEB)

    Estrada E, D


    The interest that motivated the realization of this work is the opposing discrepancy among the values of the efficiency thermoluminescent of heavy charged particles (PCP) regarding gamma radiation ({eta}{sub PCP}, {gamma}) reported in different works and gathered recently for Horowitz (Ho 01). The measures of relative thermoluminescent efficiency have importance in relation to the dosimetry associated to medical therapy with heavy charged particle. The measurement of {eta}{sub PCP}, {gamma} depends of multiple experimental factors. To understand this dependence it was quantified the effect of using different procedures experimental in the estimate of the relative thermoluminescent efficiency of dosemeters TLD-100 (LiF: Ti; Mg) for protons of 3 MeV regarding gamma rays of {sup 60}Co ({eta}{sub PCP}, {gamma}), varying the lot, the presentation, the one baked and the team reader. When was used the same global procedure values they were obtained for ({eta}{sub PCP}, {gamma}) inside the interval [0.30, 0.58] for the peak 5 and [0.35, 0.76] for the total thermoluminescent signal (Tl). At the use different equipment, baked and lot are obtained maximum differences of 30%, 12% and 6% respectively in the values of ({eta}{sub PCP}, {gamma}) for the peak 5, and 25%, 28% and 7% for the total Tl signal. The changes more significant of 36% and 44% for peak 5 and total signal respectively are obtained when changing the presentation of the dosemeter. As a complementary investigation it was studied the distribution of the Tl signal of each peak in the deconvolution of the curve of brightness with regard to the total signal in exposed dosemeters to high fluence of protons (1x10{sup 10} p/cm{sup 2}) varying the experimental protocol. It was found that the distribution of the Tl signal has a difference of the order of 5% when changing the used reading team. It was observed that the contribution of the peak 5 regarding the total signal are preserved when changing baked and that it

  10. Thermoluminescent and optical processes in alkaline halogenides dosemeters contaminated with Europium; Procesos opticos y termoluminiscentes en dosimetros de halogenuros alcalinos contaminados con Europio

    Energy Technology Data Exchange (ETDEWEB)

    Barboza F, M.; Melendrez, R.; Castaneda, B.; Pedroza M, M.; Chernov, V.; Perez S, R.; Aceves, R. [Centro de Investigacion en Fisica, Universidad de Sonora, A.P. 5-088, 83190 Hermosillo, Sonora (Mexico)


    Recent research results are presented about the properties of the optical processes of photo transferred thermoluminescence (TLFT), optical whitening (BO), thermoluminescence induced by light (TLL) and its effect in the thermoluminescent curve (Tl) produced by ionizing and non-ionizing radiation. The systematic analysis of all these processes, acquires a singular importance due that actually the alkaline halogenide crystals are object of intense investigations which analyse their potential applications as detectors and radiation dosemeters through stimulated optical luminescence techniques or thermoluminescence. The obtained data show that the Tl curve of material with this nature can be enormously affected by exposure of phosphorus to the environmental light or UV. This is in part due to liberation processes of charge bearers are shouted and makes a subsequent trapping in less temperature traps; at the same time that induce changes in the intensity of determined Tl bands. Additionally, also it is observed that mentioned phenomena are related as with wavelength of incident light as of the illumination time. Finally, the obtained information allows to conclude that although the illumination effect is extremely complex, it is associated and can be explained mainly with phenomena that implicate the electrons excitation trapped in form of F centers and trapping mechanisms or radioactive and non-radioactive recombination. (Author)

  11. Mensuration of equivalent dose with personal dosemeters and instruments of radiological protection in the new operative magnitudes ICRU, for external fields of beta radiation. Part I. Study of the homogeneity of the response personal dosemeters leaves (cards G-1, TLD-100), in radiation fields of Co{sub 60}; Medicion de dosis equivalente con dosimetros personales e instrumentos de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte I. Estudio de la homogeneidad de la respuesta dosimetros personales (tarjetas G-1, TLD-100), en campos de radiacion de Co{sub 60}

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)


    A sample of 40 composed personal dosemeters by cards model: G-l, (each card is made up of two TLD-100 crystals encapsulated in teflon), Harshaw trademark; those personal dosemeters present a free window and another with a filter of A1 of 171.7 mg cm{sup -2} of mass thickness.The objective of the work is to select of this sample of 40 personal dosemeters a population with the same stocking and standard deviation. The technique used is that of comparison of stockings, (ANOVA; Variance Analysis, when samples of the same one were had size; and/or GLM, Widespread Lineal Models, when the samples were of different size), by means of the use of those Duncan statistics, SNK, Tukey, Gabriel; the results are validated proving the kindness of adjustment of the experimental data to a Normal distribution by means of the Shapiro-Wilks statistics.The experimental design used consists on a test of two vias: a via is the variable card with two levels, (crystal 1 and 2), the other via is the variable irradiation position with four levels, (LS=left superior, SR= right superior, LI= left Inferior, IR = right inferior). The irradiations carried out in blocks of four personal dosemeters in a gamma radiation beam range of Cobalt 60; carrying out three repetitions of the design. With object of proving the homogeneity of the filter of A1 in those personal dosemeters the experimental design was executed for those cards without personal dosemeters.They were also carried out tests of stockings to the readings of bottom and sensibility of the reader equipment, (Harshaw, model marks 2271), certain that doesn{sup t} exist differences for sequence of reading, but if in the stockings of the sensibility, (they were 4 different populations). The responses of the dosemeters were corrected subtracting him the reading correspondence of bottom and by sensibility of the reader equipment before subjecting them to the tests of stockings mentioned. Of the results of the tests of stockings for the cards with

  12. Biological dosimetry, scopes and limitations; Dosimetria biologica, alcances y limitaciones

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Brena V, M. [Departamento de Biologia, Instituto Nacional de Investigaciones Nucleares, C.P. 52045 Salazar, Estado de Mexico (Mexico)


    The analysis of the aberrations in chromosomes is an alternative to establish the exposure dose to the radiation, when the information provided by the traditional physical methods is insufficient. There are diverse causes by which it can reached to apply an alternative system, such is the case of exposures of another persons to the management of radiation sources, which not carry physical dosemeter. Contrary case is to the occupational exposure personnel (OEP), what must to utilize some system for determining the exposure dose, even so can be needed the case for more information. In any case, the cells from the affected person are the alternative without the biological system be overlap to the physical, it is complementary. (Author)

  13. Determination of kinetic parameters in Tl dosemeters of LiF: Mg, Cu, P + PTFE developed in the ININ; Determinacion de parametros cineticos en dosimetros Tl de LiF: Mg, Cu, P + PTFE desarrollados en el ININ

    Energy Technology Data Exchange (ETDEWEB)

    Basurto G, B.S


    The objective of this work, is the one of determining the kinetic parameters of the dosemeter of LiF: Mg, Cu, P + Ptfe; starting from the curves Tl obtained at being irradiated with alpha radiation ({alpha}), beta ({beta}) and gamma ({gamma}). As like to compare its sensitivity with each radiation type, considering the sensitivity of the TLD-100 as the unit. In the Chapter 1, the fundamental structure of the matter is described, making emphasis in the different radiation types, and their interaction with this. In the Chapter 2, the units are described but used in the dosimetry of the radiation. In the Chapter 3, the basic concepts of the phenomenon of Tl are described and those are explained characteristic of the deconvolution method to determine the kinetics of the one phenomenon. In the Chapter 4, the methodology is detailed that was used in the elaboration of this thesis work, describing the material Tl that were considered like reference, as well as the sources of ionizing radiation, with those that the dosemeters were irradiated and the equipment in the one that the curves Tl was obtained. Reference is made to the software used to carry out the deconvolution of the curves Tl that were obtained in the one experimental development. In the Chapter 5, the obtained results of this study are presented, showing the tables of homogenization of dosemeters and the reading of the same one; they are observed the curves Tl obtained to different radiation doses (alpha, beta and gamma), the intensity Tl in function of the dose. Also they are tabulated, the obtained results in the kinetic parameters of the three different study materials (TLD-100H, USA; TLD-100, USA and LiF: Mg, Cu, P + Ptfe developed in the l.N.l.N). They are analyzed shortly for each material Tl their sensitivity to the ionizing radiation as well as their kinetic parameters. The obtained results showed that the Tl dosemeters of LiF: Mg,Cu,P + Ptfe, they presented a bigger sensitivity that the TLD-100 when

  14. Pulsed X-rays for interventional radiology: tests on active personal dosemeters (APD) (European project FP7 ORAMED WP3); Rayons X pulses pour la radiologie interventionnelle: tests sur dosimetres personnel actifs

    Energy Technology Data Exchange (ETDEWEB)

    Denoziere, M.; Bordy, J.M.; Daures, J.; Lecerf, N


    this report presents the results of the tests performed on Active Personal dosemeters (A.P.D.) to check their responses in pulsed X-ray beam used in interventional X-ray radiology. this work is one of the goal of O.R.A.M.E.D W.P.3. (Optimization of radiation protection for medical staff)The response of seven A.P.D.s types was measured in terms of dose equivalent Hp (10) for different pulsed X-ray width and dose rate. (author)

  15. Obtention of thermoluminescent efficiencies by means of irradiation of TLD-100 dosemeters with proton beams helium and carbon; Obtencion de eficiencias termoluminiscentes mediante irradiacion de dosimetros TLD-100 con haces de protones, helios y carbon

    Energy Technology Data Exchange (ETDEWEB)

    Avila, O.; Rodriguez V, M.; Aviles, P.; Gamboa de Buen, I.; Buenfil, A.E.; Ruiz T, C.; Brandan, M.E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    In this work, the advances of a serial of measurements of relative efficiency thermoluminescent of heavy charged particles (PCP) with respect to gamma radiation for TLD-100, dosemeters of LiF: Mg,Ti manufactured by the Harshaw-Bicron company are reported. The PCP are essentials in the implementation of dosimetry associated with medical applications. The measurements before gamma radiation were carrying out using the Vickrad irradiator of the National Institute of Nuclear Research at dose of 1.663 Gy. The measures which are reported about protons, helium and carbon were realized using the Pelletron accelerator of the Physics Institute of the UNAM. (Author)

  16. Chromosomal analysis and application of biological dosimetry in two cases of apparent over exposure; Analisis cromosomico y aplicacion de la dosimetria biologica en dos casos de aparente sobreexposicion

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Brena V, M. [Departamento de Biologia, ININ A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    The gamma radiation calibration curve of {sup 60} Co is used which was generated in the ININ Laboratory of Biology to calculate the exposure dose of two workers whose dosemeters marked values above of the limit allowed. The analysis indicates that in a first case, the aberrations frequency corresponded to the basal value, therefore there is not over exposure. The aberrations frequency of the second case is lightly above to the basal value and therefore the probability favors to what the physical dosimetry indicates. (Author)

  17. All biology is computational biology (United States)


    Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our understanding of life, it makes biological concepts rigorous and testable, and it provides a reference map that holds together individual insights. The next modern synthesis in biology will be driven by mathematical, statistical, and computational methods being absorbed into mainstream biological training, turning biology into a quantitative science. PMID:28278152

  18. Biological computation

    CERN Document Server

    Lamm, Ehud


    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  19. The ferrous ammonium sulfate solid system, as dosemeter for processes at low temperatures and high doses of gamma radiation; El sistema sulfato ferroso amoniacal solido, como dosimetro para procesos a bajas temperaturas y altas dosis de radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Juarez C, J.M.; Ramos B, S.; Negron M, A. [ICN-UNAM, 04510 Mexico D.F. (Mexico)


    This paper presents the results obtained from a study of the radiation induced oxidation of crystalline ferrous ammonium sulfate with gamma rays at 295 K, 263 K and 77 K and dose from 0 to 300 kGy. The radiation induced decomposition of ferrous ammonium sulfate has been studied by the dissolution of the irradiated salt in 0,8 N sulfuric acid. The main product is Fe{sup 3+} and molar concentration of ferric ion was determined spectrophotometrically in the UV region at 304 nm. The optical density values showed a linear dependence with dose, indicating that the data obtained might be used to create a calibrating curve. Color in irradiated salt changes from blue to green, yellow and orange according to the absorbed dose. The accuracy and the reproducibility of the system were tested. In addition, some other characteristics make possible the use of this system as a dosimeter, similar to Fricke chemical dosemeter, at low temperatures and high dose. (Author)

  20. The use of enriched 6Li and 7Li Lif:Mg,Cu,P glass-rod thermoluminescent dosemeters for linear accelerator out-of-field radiation dose measurements. (United States)

    Takam, R; Bezak, E; Liu, G; Marcu, L


    (6)LiF:Mg,Cu,P and (7)LiF:Mg,Cu,P glass-rod thermoluminescent dosemeters (TLDs) were used for measurements of out-of-field photon and neutron doses produced by Varian iX linear accelerator. Both TLDs were calibrated using 18-MV X-ray beam to investigate their dose-response sensitivity and linearity. CR-39 etch-track detectors (Luxel+, Landauer) were employed to provide neutron dose data to calibrate (6)LiF:Mg,Cu,P TLDs at various distances from the isocentre. With cadmium filters employed, slow neutrons (neutrons. The average in-air photon dose equivalents per monitor unit (MU) ranged from 1.5±0.4 to 215.5±94.6 μSv at 100 and 15 cm from the isocentre, respectively. Based on the cross-calibration factors obtained with CR-39 etch-track detectors, the average in-air fast neutron dose equivalents per MU range from 10.6±3.8 to 59.1±49.9 μSv at 100 and 15 cm from the isocentre, respectively. Contribution of thermal neutrons to total neutron dose equivalent was small: 3.1±7.2 μSv per MU at 15 cm from the isocentre.

  1. [Biological weapons]. (United States)

    Kerwat, K; Becker, S; Wulf, H; Densow, D


    Biological weapons are weapons of mass destruction that use pathogens (bacteria, viruses) or the toxins produced by them to target living organisms or to contaminate non-living substances. In the past, biological warfare has been repeatedly used. Anthrax, plague and smallpox are regarded as the most dangerous biological weapons by various institutions. Nowadays it seems quite unlikely that biological warfare will be employed in any military campaigns. However, the possibility remains that biological weapons may be used in acts of bioterrorism. In addition all diseases caused by biological weapons may also occur naturally or as a result of a laboratory accident. Risk assessment with regard to biological danger often proves to be difficult. In this context, an early identification of a potentially dangerous situation through experts is essential to limit the degree of damage.

  2. Comparison of two models for the X-ray dispersion produced in a Novillo Tokamak with measurements make with thermoluminescent dosemeters; Comparacion de dos modelos para la dispersion de rayos X producidos en un Novillo Tokamak con mediciones efectuadas con dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Flores O, A.; Castillo, A.; Barocio, S.R.; Melendez L, L.; Chavez A, E.; Cruz C, G.J.; Lopez, R.; Olayo, M.G.; Gonzalez M, P. [Instituto Nacional de Investigaciones Nucleares, 52045 Salazar, Estado de Mexico (Mexico); Azorin N, J. [Universidad Autonoma Metropolitana Iztapalapa, 09340 Mexico D.F. (Mexico)


    It was presented the results to study about the X-ray dispersion produced in the Novillo Tokamak using thermoluminescent dosemeters (DTL). The measurements were make in the equatorial plane of Tokamak, along twelve radial directions. The dispersion is observed due to the radiation interaction with walls surrounding the machine. It was proposed two types of heuristic mathematical methods for describing the X-ray dispersion, comparing them with the experimental data obtained with Dtl. The predictions of both models are adjusted well to the experimental data. (Author)

  3. Relative thermoluminescent efficiencies proton/gamma and helium/gamma of peaks of high temperature in TLD-100 dosemeters; Eficiencias termoluminiscentes relativas proton/gamma y helio/gamma de picos de alta temperatura en dosimetros TLD-100

    Energy Technology Data Exchange (ETDEWEB)

    Flores M, E. [UNAM, Facultad de Ciencias, 04510 Mexico D.F. (Mexico)


    The increase of the applications of ion beams in radiotherapy treatments has generated interest in the study of the thermoluminescent materials (TL) that allow to determine the applied doses. A way to quantify the TL response from these materials to ions is by means of the relative thermoluminescent efficiency. In the group of Thermoluminescent dosimetry of the Institute of Physics of the UNAM (IFUNAM) the thermoluminescent response of the TLD-100 dosemeters has been studied, which present a glow curve characteristic with several peaks that correspond to traps and luminescent centers in the material. The stable peaks know each other as 4, 5, 6a, 6b, 7, 8, 9 and 10. The efficiencies should be measured using the response so much to the radiation of interest (in this case protons and helium ions) as the response to gamma radiation. In previous works with ions of low energy taken place in the Pelletron accelerator of the IFUNAM was only measured the TL efficiency for the peak 5 and the total signal. It had not been possible to measure the efficiency of the peaks of high temperature (6a-10) because, for the gamma radiation, the peaks of high temperature show very small signals; however, recently Massillon carries out measures of efficiency TL of peaks of high temperature for ions of intermediate energy using a protocol special of reading and of deconvolution that allows to measure the signals coming from the peaks of high temperature. In this work is implemented this same protocol to complete the study of TL efficiencies at low energy of protons and helium and to determine if the values of efficiency depend on the used reading protocol. For it is reported it measures of the relative efficiency of the peaks of high temperature from the TLD-100 exposed to protons of 1.5 MeV and nuclei of helium of 3 and 7.5 MeV. (Author)

  4. Is synthetic biology mechanical biology? (United States)

    Holm, Sune


    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  5. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue


    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  6. Biological Oceanography (United States)

    Dyhrman, Sonya


    The ocean is arguably the largest habitat on the planet, and it houses an astounding array of life, from microbes to whales. As a testament to this diversity and its importance, the discipline of biological oceanography spans studies of all levels of biological organization, from that of single genes, to organisms, to their population dynamics. Biological oceanography also includes studies on how organisms interact with, and contribute to, essential global processes. Students of biological oceanography are often as comfortable looking at satellite images as they are electron micrographs. This diversity of perspective begins the textbook Biological Oceanography, with cover graphics including a Coastal Zone Color Scanner image representing chlorophyll concentration, an electron micrograph of a dinoflagellate, and a photograph of a copepod. These images instantly capture the reader's attention and illustrate some of the different scales on which budding oceanographers are required to think. Having taught a core graduate course in biological oceanography for many years, Charlie Miller has used his lecture notes as the genesis for this book. The text covers the subject of biological oceanography in a manner that is targeted to introductory graduate students, but it would also be appropriate for advanced undergraduates.

  7. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi


    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  8. Foldit Biology (United States)


    Report 8/1/2013-7/31/2015 4. TITLE AND SUBTITLE Sa. CONTRACT NUMBER Foldit Biology NOOO 14-13-C-0221 Sb. GRANT NUMBER N/A Sc. PROGRAM ELEMENT...Include area code) Unclassified Unclassified Unclassified (206) 616-2660 Zoran Popović Foldit Biology (Task 1, 2, 3, 4) Final Report...Period Covered by the Report August 1, 2013 – July 31, 2015 Date of Report: July 31, 2015 Project Title: Foldit Biology Contract Number: N00014-13

  9. Mensuration of equivalent dose with personal dosemeters and instruments of radiological protection in the new operative quantities ICRU, for external fields of beta radiation. Part II. I study of the angular response of personal dosemeters TLD-100 in secondary patron fields of beta radiation ({sup 90}Sr / {sup 90}Y); Medicion de dosis equivalente con dosimetros personales e instrumentos de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte II. Estudio de la respuesta angular de dosimetros personales TLD-100 en campos patrones secundarios de radiacion beta ({sup 90}Sr/{sup 90}Y)

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)


    The objective of this work is to carry out one of the possible ones test type for personal dosemeters TLD, under the recomendations of the ICRU 39, ICRU 43 and the draft of the norm ISO 6980,(1992), with the purpose of verifying the capacity of these detectors to carry out the operative unit: H' (0.07;{alpha}). Since H' (O. 07;{alpha}) this defined one in an expanded field, one of these tests type consist on determining the angular response of these detectors. 20 personal dosemeters TLD-100 was used, (card marks: Harshaw, Model: G-1, with two glasses of TLD-100 absorbed in teflon; the portadosemeters has two windows, a free one and another with a filter of Pb of 171.0 mg cm{sup -2}); these dosemeters they were previously selected, [to see, {sup S}tudy of the Homogeneity of the response of Personal Dosemeters (Cards G-l, TLD-100) in Radiation of Countrysides of {sup 60}Co{sup ,} J.T. Alvarez R. Technician Report GSR/IT/0001/94].The irradiations to effectued in secondary countryside of radiation beta of {sup 90}Sr/{sup 90}Y. The study was undertaken by means of an experimental design of blocks random that contemplate the following variables: intensity of the radiation source, (1850 MBq and 74 MBq); position of irradiation, (four positions); incidence of angle of the radiation (0, 15, 30, 45, 60 and 75 grades) and the absorbed dose in air, (0.005, 0.010, 0.020, 0.050 and 0.100 Gy). Then null hypothesis it was to suppose that there was not difference among the stockings of each treatment, to used the statistical of Duncan to carry out tests of stockings at a level of significance of 5%.These tests of stockings throw the following results in those variables of the experimental design: The irradiations carried out so much with the source pattern secondary of {sup 90}Sr/{sup 90}Y of 1850 MBq and of 74 MBq, they are equivalent reason why they can be used indistinctly. The responses of each one of the glasses of the card are strongly anisotropic for each glass

  10. Characteristic parameters analysis on diagnostic X-ray beams for dosemeter calibration; Analise de parametros caracteristicos de feixes de raios-X diagnostico para calibracao de dosimetros

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Paulo Marcio Campos de


    Ionizing radiation metrology is the base to achieve reliable dose measurements in ali areas; it is also part of the framework that is established to assure radiation protection procedures in order to avoid or minimize the harmful biological effect that may be caused by ionizing radiation. A well done metrology means the use of reliable instruments that comply with standard performance requirements worldwide accepted. Those instruments are expected to be calibrated by Metrology Laboratories under well defined conditions. The International Electrotechnical Commission (IEC) in Standard 61267 established the reference radiations for medical diagnostic x-ray equipment that are recommended to be used for calibrating dosimetric systems for diagnostic dosimetry. In this work, X-ray beam qualities were established in a Calibration Laboratory and their characteristics were analyzed through the measurement of beam parameters like inherent tube filtration, beam uniformity and field size, energy spectra and peak voltage for additional filtration with 94.425 por cent and 99.999 por cent purity filters. Also, the first half-value layer and the homogeneity coefficient were measured for the three RQR 2, RQR 6 and RQR 10 IEC beam qualities and they were analyzed according to the IEC standard. Air-kerma measurements were carried out with an ionization chamber that had its reliability confirmed through repetition and reproducibility reading tests. In 50 sets of measurements the maximum standard deviation found of 10 successive readings was 0.19 %; the maximum shift of the reading mean value at a fixed geometry condition was 0.80 % with an overall standard deviation of 0.23 %. Results showed that the use of different purity filters did not cause a relevant influence on the beam energy spectra. An ionization chamber was also calibrated against a standard dosimeter in ali implemented reference radiations and the relevant sources of uncertainties were estimated. Calibration could be done

  11. Biological preconcentrator (United States)

    Manginell, Ronald P.; Bunker, Bruce C.; Huber, Dale L.


    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  12. Biology Notes. (United States)

    School Science Review, 1981


    Outlines a variety of laboratory procedures, techniques, and materials including construction of a survey frame for field biology, a simple tidal system, isolation and applications of plant protoplasts, tropisms, teaching lung structure, and a key to statistical methods for biologists. (DS)

  13. (Biological dosimetry)

    Energy Technology Data Exchange (ETDEWEB)

    Preston, R.J.


    The traveler attended the 1st International Conference on Biological Dosimetry in Madrid, Spain. This conference was organized to provide information to a general audience of biologists, physicists, radiotherapists, industrial hygiene personnel and individuals from related fields on the current ability of cytogenetic analysis to provide estimates of radiation dose in cases of occupational or environmental exposure. There is a growing interest in Spain in biological dosimetry because of the increased use of radiation sources for medical and occupational uses, and with this the anticipated and actual increase in numbers of overexposure. The traveler delivered the introductory lecture on Biological Dosimetry: Mechanistic Concepts'' that was intended to provide a framework by which the more applied lectures could be interpreted in a mechanistic way. A second component of the trip was to provide advice with regard to several recent cases of overexposure that had been or were being assessed by the Radiopathology and Radiotherapy Department of the Hospital General Gregorio Maranon'' in Madrid. The traveler had provided information on several of these, and had analyzed cells from some exposed or purportedly exposed individuals. The members of the biological dosimetry group were referred to individuals at REACTS at Oak Ridge Associated Universities for advice on follow-up treatment.

  14. Marine Biology (United States)

    Dewees, Christopher M.; Hooper, Jon K.


    A variety of informational material for a course in marine biology or oceanology at the secondary level is presented. Among the topics discussed are: food webs and pyramids, planktonic blooms, marine life, plankton nets, food chains, phytoplankton, zooplankton, larval plankton and filter feeders. (BT)

  15. Scaffolded biology. (United States)

    Minelli, Alessandro


    Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as Dawkins' extended phenotype, Turner's extended organism, Oyama's Developmental Systems Theory and Odling-Smee's niche construction theory. Last in time is the description of biological phenomena in terms of hybrids between an organism (scaffolded system) and a living or non-living scaffold, forming unit systems to study processes such as reproduction and development. As scaffold, eventually, we can define any resource used by the biological system, especially in development and reproduction, without incorporating it as happens in the case of resources fueling metabolism. Addressing biological systems as functionally scaffolded systems may help pointing to functional relationships that can impart temporal marking to the developmental process and thus explain its irreversibility; revisiting the boundary between development and metabolism and also regeneration phenomena, by suggesting a conceptual framework within which to investigate phenomena of regular hypermorphic regeneration such as characteristic of deer antlers; fixing a periodization of development in terms of the times at which a scaffolding relationship begins or is terminated; and promoting plant galls to legitimate study objects of developmental biology.

  16. Biology Notes. (United States)

    School Science Review, 1984


    Presents information on the teaching of nutrition (including new information relating to many current O-level syllabi) and part 16 of a reading list for A- and S-level biology. Also includes a note on using earthworms as a source of material for teaching meiosis. (JN)

  17. Mesoscopic biology

    Indian Academy of Sciences (India)

    G V Shivashankar


    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological systems. In recent years advances in technology have led to the study of some of the design principles of these machines; in particular at the level of an individual molecule. For example, the forces that operate in molecular interactions, the stochasticity involved in these interactions and their spatio-temporal dynamics are beginning to be explored. Understanding such design principles is opening new possibilities in mesoscopic physics with potential applications.

  18. Marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Thurman, H.V.; Webber, H.H.


    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index.

  19. Biological Databases

    Directory of Open Access Journals (Sweden)

    Kaviena Baskaran


    Full Text Available Biology has entered a new era in distributing information based on database and this collection of database become primary in publishing information. This data publishing is done through Internet Gopher where information resources easy and affordable offered by powerful research tools. The more important thing now is the development of high quality and professionally operated electronic data publishing sites. To enhance the service and appropriate editorial and policies for electronic data publishing has been established and editors of article shoulder the responsibility.

  20. HSP as bio dosemeters; HSP como biodosimetros

    Energy Technology Data Exchange (ETDEWEB)

    Manzanares A, E.; Vega C, H.R. [Grupo Academico de Radiobiologia, UAZ, A.P. 336, 98000 Zacatecas (Mexico)


    A review of the more important passages for the field of the radiological protection, from the discovery, beginnings of the utilization of the radiations emitting, passing to the legislation proposals and the transformations that had been suffer to establish the international standards of radiological protection. The paradigms on the effects and chronologically the emanated discoveries of the cellular research and the measurement of cellular products in the species and the diverse alive beings making emphasis in evaluating the expression of the heat-shock proteins caused by low doses of gamma radiation, these are used as radiation bio monitors and of other agents that cause cellular stress and lastly a prospective of the future of the radiobiology. (Author)

  1. Biological biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Jorge-Herrero, E. [Servicio de Cirugia Experimental. Clinica Puerta de Hierro, Madrid (Spain)


    There are a number of situations in which substances of biological origin are employed as biomaterials. Most of them are macromolecules derived from isolated connective tissue or the connective tissue itself in membrane form, in both cases, the tissue can be used in its natural form or be chemically treated. In other cases, certain blood vessels can be chemically pretreated and used as vascular prostheses. Proteins such as albumin, collagen and fibrinogen are employed to coat vascular prostheses. Certain polysaccharides have also been tested for use in controlled drug release systems. Likewise, a number of tissues, such as dura mater, bovine pericardium, procine valves and human valves, are used in the preparation of cardiac prostheses. We also use veins from animals or humans in arterial replacement. In none of these cases are the tissues employed dissimilar to the native tissues as they have been chemically modified, becoming a new bio material with different physical and biochemical properties. In short, we find that natural products are being utilized as biomaterials and must be considered as such; thus, it is necessary to study both their chemicobiological and physicomechanical properties. In the present report, we review the current applications, problems and future prospects of some of these biological biomaterials. (Author) 84 refs.

  2. Structural Biology Fact Sheet (United States)

    ... Home > Science Education > Structural Biology Fact Sheet Structural Biology Fact Sheet Tagline (Optional) Middle/Main Content Area What is structural biology? Structural biology is a field of science focused ...

  3. Simulating Biological and Non-Biological Motion (United States)

    Bruzzo, Angela; Gesierich, Benno; Wohlschlager, Andreas


    It is widely accepted that the brain processes biological and non-biological movements in distinct neural circuits. Biological motion, in contrast to non-biological motion, refers to active movements of living beings. Aim of our experiment was to investigate the mechanisms underlying mental simulation of these two movement types. Subjects had to…

  4. A Brief Introduction to Chinese Biological Biological

    Institute of Scientific and Technical Information of China (English)


    Chinese Biological Abstracts sponsored by the Library, the Shanghai Institutes for Biological Sciences, the Biological Documentation and Information Network, all of the Chinese Academy of Sciences, commenced publication in 1987 and was initiated to provide access to the Chinese information in the field of biology.

  5. Cell biology perspectives in phage biology. (United States)

    Ansaldi, Mireille


    Cellular biology has long been restricted to large cellular organisms. However, as the resolution of microscopic methods increased, it became possible to study smaller cells, in particular bacterial cells. Bacteriophage biology is one aspect of bacterial cell biology that has recently gained insight from cell biology. Despite their small size, bacteriophages could be successfully labeled and their cycle studied in the host cells. This review aims to put together, although non-extensively, several cell biology studies that recently pushed the elucidation of key mechanisms in phage biology, such as the lysis-lysogeny decision in temperate phages or genome replication and transcription, one step further.

  6. Biological warfare agents. (United States)

    Pohanka, Miroslav; Kuca, Kamil


    Biological warfare agents are a group of pathogens and toxins of biological origin that can be potentially misused for military or criminal purposes. The present review attempts to summarize necessary knowledge about biological warfare agents. The historical aspects, examples of applications of these agents such as anthrax letters, biological weapons impact, a summary of biological warfare agents and epidemiology of infections are described. The last section tries to estimate future trends in research on biological warfare agents.

  7. Calibration of photographic dosemeters to evaluate the personal equivalent dose, Hp (10), irradiated by different radiation qualities and angles of incidence; Calibracao de dosimetros fotograficos para avaliar o equivalente de dose pessoal, Hp(10), irradiados por diferentes qualidades de radiacao e angulos de incidencia

    Energy Technology Data Exchange (ETDEWEB)

    Santoro, Christiana; Antonio Filho, Joao, E-mail:, E-mail: [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Departamento de Energia Nuclear; Santos, Marcus Aurelio P.; Goncalves Filho, Luiz Carlos, E-mail:, E-mail: [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, Pe (Brazil)


    To use radiation detectors, should periodically perform tests and calibrations on instruments in order to verify its good functionality. One way to ascertain the quality of the instrument is to conduct a study of the angular dependence of the response of the radiation detectors. The photographic dosimetry has been used widely to quantify the radiation doses and to estimate levels of doses received by workers involved with X-and gamma radiation. Photographic dosimeters are used because provide wide range of exposure and good accuracy. One of the sources of error have been introduced by different irradiation geometries between calibration and measurement in radiation fields used in x-ray and gamma ray sources, therefore, there is a need for an evaluation of the sensitivity of dosimeters with variation of the angle of the incident beam. In this study were tested 190 photographic dosemeters in the Metrology Laboratory of the Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE) using the phantom H{sub p} (10), where the dosimeters are evaluated on the basis of the new operational magnitude for individual monitoring, the equivalent personal dose, H{sub p} (10). Angular dependence of these radiation detectors was studied in X radiation fields (in the range of 45 keV energy to 164 keV) and gamma radiation ({sup 137}Cs-662 keV e {sup 60}Co - 1250 keV)

  8. Biological conversion system (United States)

    Scott, C.D.

    A system for bioconversion of organic material comprises a primary bioreactor column wherein a biological active agent (zymomonas mobilis) converts the organic material (sugar) to a product (alcohol), a rejuvenator column wherein the biological activity of said biological active agent is enhanced, and means for circulating said biological active agent between said primary bioreactor column and said rejuvenator column.

  9. Synthetic biology: insights into biological computation. (United States)

    Manzoni, Romilde; Urrios, Arturo; Velazquez-Garcia, Silvia; de Nadal, Eulàlia; Posas, Francesc


    Organisms have evolved a broad array of complex signaling mechanisms that allow them to survive in a wide range of environmental conditions. They are able to sense external inputs and produce an output response by computing the information. Synthetic biology attempts to rationally engineer biological systems in order to perform desired functions. Our increasing understanding of biological systems guides this rational design, while the huge background in electronics for building circuits defines the methodology. In this context, biocomputation is the branch of synthetic biology aimed at implementing artificial computational devices using engineered biological motifs as building blocks. Biocomputational devices are defined as biological systems that are able to integrate inputs and return outputs following pre-determined rules. Over the last decade the number of available synthetic engineered devices has increased exponentially; simple and complex circuits have been built in bacteria, yeast and mammalian cells. These devices can manage and store information, take decisions based on past and present inputs, and even convert a transient signal into a sustained response. The field is experiencing a fast growth and every day it is easier to implement more complex biological functions. This is mainly due to advances in in vitro DNA synthesis, new genome editing tools, novel molecular cloning techniques, continuously growing part libraries as well as other technological advances. This allows that digital computation can now be engineered and implemented in biological systems. Simple logic gates can be implemented and connected to perform novel desired functions or to better understand and redesign biological processes. Synthetic biological digital circuits could lead to new therapeutic approaches, as well as new and efficient ways to produce complex molecules such as antibiotics, bioplastics or biofuels. Biological computation not only provides possible biomedical and

  10. Translational environmental biology: cell biology informing conservation. (United States)

    Traylor-Knowles, Nikki; Palumbi, Stephen R


    Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate immunity and acclimatization have prompted new developments in conservation. Similar to biomedicine, we urge that future efforts should focus on better frameworks for biomarker development to protect coral reefs.

  11. Computational Systems Chemical Biology


    Oprea, Tudor I.; Elebeoba E. May; Leitão, Andrei; Tropsha, Alexander


    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically-based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology, SCB (Oprea et al., 2007).

  12. Resetting Biological Clocks (United States)

    Winfree, Arthur T.


    Reports on experiments conducted on two biological clocks, in organisms in the plant and animal kingdoms, which indicate that biological oscillation can be arrested by a single stimulus of a definite strength delivered at the proper time. (GS)

  13. Biology is simple. (United States)

    Newman, Tim


    This paper explores the potential for simplicity to reveal new biological understanding. Borrowing selectively from physics thinking, and contrasting with Crick's reductionist philosophy, the author argues that greater emphasis on simplicity is necessary to advance biology and its applications.

  14. Biology of Blood (United States)

    ... here for the Professional Version Home Blood Disorders Biology of Blood Overview of Blood Resources In This ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  15. Designing synthetic biology. (United States)

    Agapakis, Christina M


    Synthetic biology is frequently defined as the application of engineering design principles to biology. Such principles are intended to streamline the practice of biological engineering, to shorten the time required to design, build, and test synthetic gene networks. This streamlining of iterative design cycles can facilitate the future construction of biological systems for a range of applications in the production of fuels, foods, materials, and medicines. The promise of these potential applications as well as the emphasis on design has prompted critical reflection on synthetic biology from design theorists and practicing designers from many fields, who can bring valuable perspectives to the discipline. While interdisciplinary connections between biologists and engineers have built synthetic biology via the science and the technology of biology, interdisciplinary collaboration with artists, designers, and social theorists can provide insight on the connections between technology and society. Such collaborations can open up new avenues and new principles for research and design, as well as shed new light on the challenging context-dependence-both biological and social-that face living technologies at many scales. This review is inspired by the session titled "Design and Synthetic Biology: Connecting People and Technology" at Synthetic Biology 6.0 and covers a range of literature on design practice in synthetic biology and beyond. Critical engagement with how design is used to shape the discipline opens up new possibilities for how we might design the future of synthetic biology.




  17. Biology Myth-Killers (United States)

    Lampert, Evan


    "Biology Myth-Killers" is an activity designed to identify and correct common misconceptions for high school and college introductory biology courses. Students identify common myths, which double as biology misconceptions, and use appropriate sources to share the "truth" about the myths. This learner-centered activity is a fun…

  18. Computational systems chemical biology. (United States)

    Oprea, Tudor I; May, Elebeoba E; Leitão, Andrei; Tropsha, Alexander


    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology (SCB) (Nat Chem Biol 3: 447-450, 2007).The overarching goal of computational SCB is to develop tools for integrated chemical-biological data acquisition, filtering and processing, by taking into account relevant information related to interactions between proteins and small molecules, possible metabolic transformations of small molecules, as well as associated information related to genes, networks, small molecules, and, where applicable, mutants and variants of those proteins. There is yet an unmet need to develop an integrated in silico pharmacology/systems biology continuum that embeds drug-target-clinical outcome (DTCO) triplets, a capability that is vital to the future of chemical biology, pharmacology, and systems biology. Through the development of the SCB approach, scientists will be able to start addressing, in an integrated simulation environment, questions that make the best use of our ever-growing chemical and biological data repositories at the system-wide level. This chapter reviews some of the major research concepts and describes key components that constitute the emerging area of computational systems chemical biology.

  19. Quantum biological information theory

    CERN Document Server

    Djordjevic, Ivan B


    This book is a self-contained, tutorial-based introduction to quantum information theory and quantum biology. It serves as a single-source reference to the topic for researchers in bioengineering, communications engineering, electrical engineering, applied mathematics, biology, computer science, and physics. The book provides all the essential principles of the quantum biological information theory required to describe the quantum information transfer from DNA to proteins, the sources of genetic noise and genetic errors as well as their effects. Integrates quantum information and quantum biology concepts; Assumes only knowledge of basic concepts of vector algebra at undergraduate level; Provides a thorough introduction to basic concepts of quantum information processing, quantum information theory, and quantum biology; Includes in-depth discussion of the quantum biological channel modelling, quantum biological channel capacity calculation, quantum models of aging, quantum models of evolution, quantum models o...

  20. Standard biological parts knowledgebase. (United States)

    Galdzicki, Michal; Rodriguez, Cesar; Chandran, Deepak; Sauro, Herbert M; Gennari, John H


    We have created the Knowledgebase of Standard Biological Parts (SBPkb) as a publically accessible Semantic Web resource for synthetic biology ( The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts ( SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL), a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  1. Standard biological parts knowledgebase.

    Directory of Open Access Journals (Sweden)

    Michal Galdzicki

    Full Text Available We have created the Knowledgebase of Standard Biological Parts (SBPkb as a publically accessible Semantic Web resource for synthetic biology ( The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts ( SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL, a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  2. Plant synthetic biology. (United States)

    Liu, Wusheng; Stewart, C Neal


    Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants.

  3. Branching processes in biology

    CERN Document Server

    Kimmel, Marek


    This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second ex...

  4. Chemical Biology is.....



    Chemical Biology is a relatively new field, and as such is not yet simply or succinctly defined. It includes such a wide range of fundamental problems that this commentary could only include just a few snapshots of potential areas of interest. Overarching themes and selected recent successes and ideas in chemical biology are described to illustrate broadly the scope of the field, but should not be taken as exhaustive. The Chemical Biology Section of Chemistry Central Journal is pleased to rec...

  5. Biological detector and method

    Energy Technology Data Exchange (ETDEWEB)

    Sillerud, Laurel; Alam, Todd M.; McDowell, Andrew F.


    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  6. Biological detector and method (United States)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F


    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  7. Biological Individuality of Man (United States)


    RECIPIENT’S CAT * LOO NUMBER Biological Individuality of Man 5 TlrPE OF REPORT a PERIOD COVERED Technical « PERFORMING ORO REPORT...Variability 13 A. Background , 13 B. Slatistictl Approaches to Biological Variability 13 C. Genetic Aspects of Biological Variability . 14 III...ioiological determinants of individuality. Only recently, have genetic infaienccs been investigated and the potentialities for future control of bio

  8. Biological detector and method (United States)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F


    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  9. Chemical space and biology. (United States)

    Dobson, Christopher M


    Chemical space--which encompasses all possible small organic molecules, including those present in biological systems--is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs. The discovery of new bioactive molecules, facilitated by a deeper understanding of the nature of the regions of chemical space that are relevant to biology, will advance our knowledge of biological processes and lead to new strategies to treat disease.

  10. Polythiophenes in biological applications. (United States)

    Sista, Prakash; Ghosh, Koushik; Martinez, Jennifer S; Rocha, Reginaldo C


    Polythiophene and its derivatives have shown tremendous potential for interfacing electrically conducting polymers with biological applications. These semiconducting organic polymers are relatively soft, conduct electrons and ions, have low cytotoxicity, and can undergo facile chemical modifications. In addition, the reduction in electrical impedance of electrodes coated with polythiophenes may prove to be invaluable for a stable and permanent connection between devices and biological tissues. This review article focuses on the synthesis and some key applications of polythiophenes in multidisciplinary areas at the interface with biology. These polymers have shown tremendous potential in biological applications such as diagnostics, therapy, drug delivery, imaging, implant devices and artificial organs.

  11. Biology Library Workbook. (United States)

    Miller, Constance; And Others

    A library skills workbook provides college biology students with an introduction to biological library resources. Divided into two sections, the first contains explanations of the various steps in the library research process. The second consists of exercises keyed to the explanatory chapters of the first section. (RAA)

  12. Homosexuality, biology, and ideology. (United States)

    Haumann, G


    This paper critically examines the complex relationships and interdependencies between biological theories on homosexuality and sociosexual ideologies. It challenges the privileged status of biology as the ultimate authority on homosexuality. This status is based on the belief that biology is a value-free science. On the contrary, this essay shows how unacknowledged assumptions and culturally bound patterns of thinking about sexuality taint biological research. Sociosexual ideologies are defined as principles that organize the ways we express our sexualities and the way we theorize about them in biology. The following ideologies are identified: (1) sexuality-as-heterosexuality, (2) sexuality-as-reproduction, (3) sexual dualism (male vs. female), and (4) the view the homosexuality is a sexual inversion. The process by which these ideologies are incorporated into biology is two-fold: (1) as a projective act from society onto nature and (2) as a reflective act from nature back into society. It is further argued that biological knowledge of homosexuality resulting from that process can be used for diverse political interests. Finally, it is proposed that since biological theories on homosexuality are inseparable from the context of their paradigmatic origin, it is possible that new theories could be derived from new ideologies.

  13. Psoriasis : implications of biologics

    NARCIS (Netherlands)

    Lecluse, L.L.A.


    Since the end of 2004 several specific immunomodulating therapies: ‘biologic response modifiers’ or ‘biologics’ have been registered for moderate to severe psoriasis in Europe. This thesis is considering the implications of the introduction of the biologics for psoriasis patients, focusing on safety

  14. Biological Macromolecule Crystallization Database (United States)

    SRD 21 Biological Macromolecule Crystallization Database (Web, free access)   The Biological Macromolecule Crystallization Database and NASA Archive for Protein Crystal Growth Data (BMCD) contains the conditions reported for the crystallization of proteins and nucleic acids used in X-ray structure determinations and archives the results of microgravity macromolecule crystallization studies.

  15. Experimenting with Mathematical Biology (United States)

    Sanft, Rebecca; Walter, Anne


    St. Olaf College recently added a Mathematical Biology concentration to its curriculum. The core course, Mathematics of Biology, was redesigned to include a wet laboratory. The lab classes required students to collect data and implement the essential modeling techniques of formulation, implementation, validation, and analysis. The four labs…

  16. Introduction to systems biology

    NARCIS (Netherlands)

    Bruggeman, F.J.; Hornberg, J.J.; Boogerd, F.C.; Westerhoff, H.V.; Boogerd, F.C.; Bruggeman, F.J.; Hofmeyr, J.H.S.; Westerhoff, H.V.


    The developments in the molecular biosciences have made possible a shift to combined molecular and system-level approaches to biological research under the name of Systems Biology. It integrates many types of molecular knowledge, which can best be achieved by the synergistic use of models and experi

  17. Frontiers in mathematical biology

    CERN Document Server


    Volume 100, which is the final volume of the LNBM series serves to commemorate the acievements in two decades of this influential collection of books in mathematical biology. The contributions, by the leading mathematical biologists, survey the state of the art in the subject, and offer speculative, philosophical and critical analyses of the key issues confronting the field. The papers address fundamental issues in cell and molecular biology, organismal biology, evolutionary biology, population ecology, community and ecosystem ecology, and applied biology, plus the explicit and implicit mathematical challenges. Cross-cuttting issues involve the problem of variation among units in nonlinear systems, and the related problems of the interactions among phenomena across scales of space, time and organizational complexity.

  18. Space biology research development (United States)

    Bonting, Sjoerd L.


    The purpose of the Search for Extraterrestrial Intelligence (SETI) Institute is to conduct and promote research related activities regarding the search for extraterrestrial life, particularly intelligent life. Such research encompasses the broad discipline of 'Life in the Universe', including all scientific and technological aspects of astronomy and the planetary sciences, chemical evolution, the origin of life, biological evolution, and cultural evolution. The primary purpose was to provide funding for the Principal Investigator to collaborate with the personnel of the SETI Institute and the NASA-Ames Research center in order to plan and develop space biology research on and in connection with Space Station Freedom; to promote cooperation with the international partners in the space station; to conduct a study on the use of biosensors in space biology research and life support system operation; and to promote space biology research through the initiation of an annual publication 'Advances in Space Biology and Medicine'.

  19. Optics of Biological Particles

    CERN Document Server

    Hoekstra, Alfons; Videen, Gorden


    This book covers the optics of single biological particles, both theory and experiment, with emphasis on Elastic Light Scattering and Fluorescence. It deals with the optics of bacteria (bio-aerosols), marine particles (selected phytoplankton communities) and red and white blood cells. Moreover, there are dedicated chapters on a general theory for scattering by a cell, and modelling and simulation of scattering by inhomogeneous biological cells. Finally, one chapter is dedicated to astro-biological signatures, discussing the possibilities for detecting non-terrestrial biological material. The volume has up-to-date discussions on new experimental and numerical techniques, and many examples of applications of these techniques in real-life systems, as used to detect and characterize e.g. biological warfare agents or human blood cells.

  20. Biological sample collector (United States)

    Murphy, Gloria A.


    A biological sample collector is adapted to a collect several biological samples in a plurality of filter wells. A biological sample collector may comprise a manifold plate for mounting a filter plate thereon, the filter plate having a plurality of filter wells therein; a hollow slider for engaging and positioning a tube that slides therethrough; and a slide case within which the hollow slider travels to allow the tube to be aligned with a selected filter well of the plurality of filter wells, wherein when the tube is aligned with the selected filter well, the tube is pushed through the hollow slider and into the selected filter well to sealingly engage the selected filter well and to allow the tube to deposit a biological sample onto a filter in the bottom of the selected filter well. The biological sample collector may be portable.

  1. Managing biological diversity (United States)

    Samson, Fred B.; Knopf, Fritz L.


    Biological diversity is the variety of life and accompanying ecological processes (Off. Technol. Assess. 1987, Wilcove and Samson 1987, Keystone 1991). Conservation of biological diversity is a major environmental issue (Wilson 1988, Counc. Environ. Quality 1991). The health and future of the earth's ecological systems (Lubchenco et al. 1991), global climate change (Botkin 1990), and an ever-increasing rate in loss of species, communities, and ecological systems (Myers 1990) are among issues drawing biological diversity to the mainstream of conservation worldwide (Int. Union Conserv. Nat. and Nat. Resour. [IUCN] et al. 1991). The legal mandate for conserving biological diversity is now in place (Carlson 1988, Doremus 1991). More than 19 federal laws govern the use of biological resources in the United States (Rein 1991). The proposed National Biological Diversity Conservation and Environmental Research Act (H.R. 585 and S.58) notes the need for a national biological diversity policy, would create a national center for biological diversity research, and recommends a federal interagency strategy for ecosystem conservation. There are, however, hard choices ahead for the conservation of biological diversity, and biologists are grappling with how to set priorities in research and management (Roberts 1988). We sense disillusion among field biologists and managers relative to how to operationally approach the seemingly overwhelming charge of conserving biological diversity. Biologists also need to respond to critics like Hunt (1991) who suggest a tree farm has more biological diversity than an equal area of old-growth forest. At present, science has played only a minor role in the conservation of biological diversity (Weston 1992) with no unified approach available to evaluate strategies and programs that address the quality and quantity of biological diversity (Murphy 1990, Erwin 1992). Although actions to conserve biological diversity need to be clearly defined by

  2. Biological and Chemical Security

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, P J


    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  3. Thermodynamics of Biological Processes (United States)

    Garcia, Hernan G.; Kondev, Jane; Orme, Nigel; Theriot, Julie A.; Phillips, Rob


    There is a long and rich tradition of using ideas from both equilibrium thermodynamics and its microscopic partner theory of equilibrium statistical mechanics. In this chapter, we provide some background on the origins of the seemingly unreasonable effectiveness of ideas from both thermodynamics and statistical mechanics in biology. After making a description of these foundational issues, we turn to a series of case studies primarily focused on binding that are intended to illustrate the broad biological reach of equilibrium thinking in biology. These case studies include ligand-gated ion channels, thermodynamic models of transcription, and recent applications to the problem of bacterial chemotaxis. As part of the description of these case studies, we explore a number of different uses of the famed Monod–Wyman–Changeux (MWC) model as a generic tool for providing a mathematical characterization of two-state systems. These case studies should provide a template for tailoring equilibrium ideas to other problems of biological interest. PMID:21333788

  4. Hammond Bay Biological Station (United States)

    Federal Laboratory Consortium — Hammond Bay Biological Station (HBBS), located near Millersburg, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). HBBS was established by...

  5. Enhanced Biological Sampling Data (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is a database of a variety of biological, reproductive, and energetic data collected from fish on the continental shelf in the northwest Atlantic Ocean. Species...

  6. Chemistry and biology data (United States)

    U.S. Environmental Protection Agency — Chemical monitoring data and biological data from field collected samples. This dataset is associated with the following publication: Biales , A., D. Denton , D....

  7. Laboratory of Biological Modeling (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to...

  8. Laboratory of Biological Modeling (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to a...

  9. Precision Measurement in Biology (United States)

    Quake, Stephen

    Is biology a quantitative science like physics? I will discuss the role of precision measurement in both physics and biology, and argue that in fact both fields can be tied together by the use and consequences of precision measurement. The elementary quanta of biology are twofold: the macromolecule and the cell. Cells are the fundamental unit of life, and macromolecules are the fundamental elements of the cell. I will describe how precision measurements have been used to explore the basic properties of these quanta, and more generally how the quest for higher precision almost inevitably leads to the development of new technologies, which in turn catalyze further scientific discovery. In the 21st century, there are no remaining experimental barriers to biology becoming a truly quantitative and mathematical science.

  10. Biological satellite Kosmos-936 (United States)

    Vedeshin, L. A.


    A description is given of physiological experiments performed on the biological satellite Kosmos-936. Other experiments to determine the electrostatic and dielectric responses to the effects of cosmic radiation are discussed.

  11. Fishery Biology Database (AGDBS) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Basic biological data are the foundation on which all assessments of fisheries resources are built. These include parameters such as the size and age composition of...

  12. Large Pelagics Biological Survey (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Large Pelagics Biological Survey (LPBS) collects additional length and weight information and body parts such as otoliths, caudal vertebrae, dorsal spines, and...

  13. Vibrations, Quanta and Biology

    CERN Document Server

    Huelga, S F


    Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the dynamics of quantum dynamical networks in the presence of an environment and the fruitful interplay that the two may enter. At the hand of three biological phenomena whose understanding is held to require quantum mechanical processes, namely excitation and charge transfer in photosynthetic complexes, magneto-reception in birds and the olfactory sense, we demonstrate that this underlying theme encompasses them all, thus suggesting its wider relevance as an archetypical framework for quantum biology.

  14. Mechanical Biological Treatment

    DEFF Research Database (Denmark)

    Bilitewski, B-; Oros, Christiane; Christensen, Thomas Højlund


    or residual waste (after some recyclables removed at the source). The concept was originally to reduce the amount of waste going to landfill, but MBT technologies are today also seen as plants recovering fuel as well as material fractions. As the name suggests the technology combines mechanical treatment......The basic processes and technologies of composting and anaerobic digestion, as described in the previous chapters, are usually used for specific or source-separated organic waste flows. However, in the 1990s mechanical biological waste treatment technologies (MBT) were developed for unsorted...... technologies (screens, sieves, magnets, etc.) with biological technologies (composting, anaerobic digestion). Two main technologies are available: Mechanical biological pretreatment (MBP), which first removes an RDF fraction and then biologically treats the remaining waste before most of it is landfilled...

  15. Multiscale Biological Materials

    DEFF Research Database (Denmark)

    Frølich, Simon

    example of biological design. We investigated the architecture of A. simplex and found that an advanced hierarchical biomineralized structure acts as the interface between soft musculature and a stiff substrate, thus securing underwater attachment. In bone, the mechanical properties of the material......, and the nanoscale response of bone in compression. Lastly, a framework for the investigation of biological design principles has been developed. The framework combines parametric modeling, multi-material 3D-printing, and direct mechanical testing to efficiently screen large parameter spaces of biological design. We......Materials formed by organisms, also known as biological materials, exhibit outstanding structural properties. The range of materials formed in nature is remarkable and their functions include support, protection, motion, sensing, storage, and maintenance of physiological homeostasis. These complex...

  16. [Systems biology of cancer]. (United States)

    Barillot, Emmanuel; Calzone, Laurence; Zinovyev, Andrei


    Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an interaction network governing essential cellular events such as proliferation, differentiation, cell death...) in order to facilitate the interpretation of molecular profiles of tumors. The translation of these networks into mathematical models allows prediction of the evolution of the system in time and under certain perturbations. As a result, it can not only propose specific target points for pharmaceutical purposes, but also anticipate the evolution of tumors as well as their classifications. These characteristics emphasize the important role of Systems Biology of Cancer in the future of biomedical research.

  17. Insecticides and Biological Control (United States)

    Furness, G. O.


    Use of insecticides has been questioned due to their harmful effects on edible items. Biological control of insects along with other effective practices for checking spread of parasites on crops are discussed. (PS)

  18. Nestedness across biological scales (United States)

    Marquitti, Flavia M. D.; Raimundo, Rafael L. G.; Sebastián-González, Esther; Coltri, Patricia P.; Perez, S. Ivan; Brandt, Débora Y. C.; Nunes, Kelly; Daura-Jorge, Fábio G.; Floeter, Sergio R.; Guimarães, Paulo R.


    Biological networks pervade nature. They describe systems throughout all levels of biological organization, from molecules regulating metabolism to species interactions that shape ecosystem dynamics. The network thinking revealed recurrent organizational patterns in complex biological systems, such as the formation of semi-independent groups of connected elements (modularity) and non-random distributions of interactions among elements. Other structural patterns, such as nestedness, have been primarily assessed in ecological networks formed by two non-overlapping sets of elements; information on its occurrence on other levels of organization is lacking. Nestedness occurs when interactions of less connected elements form proper subsets of the interactions of more connected elements. Only recently these properties began to be appreciated in one-mode networks (where all elements can interact) which describe a much wider variety of biological phenomena. Here, we compute nestedness in a diverse collection of one-mode networked systems from six different levels of biological organization depicting gene and protein interactions, complex phenotypes, animal societies, metapopulations, food webs and vertebrate metacommunities. Our findings suggest that nestedness emerge independently of interaction type or biological scale and reveal that disparate systems can share nested organization features characterized by inclusive subsets of interacting elements with decreasing connectedness. We primarily explore the implications of a nested structure for each of these studied systems, then theorize on how nested networks are assembled. We hypothesize that nestedness emerges across scales due to processes that, although system-dependent, may share a general compromise between two features: specificity (the number of interactions the elements of the system can have) and affinity (how these elements can be connected to each other). Our findings suggesting occurrence of nestedness

  19. Biological Parameters of Impact (United States)


    zone between no effect and gross injury or death . For example, the pilot who survives an aircraft crash, but who is injured or unconscious so that he...Biological effects were limited to one incidence of bradycardia (116 t36 t and three instances of premature ventricular contractions. However. subjeCtiY" I...R.F.Chandler INTRODUCTION -Investigation of the biological effects of abrupt acceleration (impact) was stimulated by the advent of technical advances

  20. Systems cell biology. (United States)

    Mast, Fred D; Ratushny, Alexander V; Aitchison, John D


    Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of cells. Merging technology and computation offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.

  1. FDA 101: Regulating Biological Products (United States)

    ... Products For Consumers Home For Consumers Consumer Updates FDA 101: Regulating Biological Products Share Tweet Linkedin Pin ... field. back to top What biological products does FDA regulate? The Center for Biologics Evaluation and Research ( ...

  2. Stochastic Methods in Biology

    CERN Document Server

    Kallianpur, Gopinath; Hida, Takeyuki


    The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

  3. Biological warfare agents

    Directory of Open Access Journals (Sweden)

    Duraipandian Thavaselvam


    Full Text Available The recent bioterrorist attacks using anthrax spores have emphasized the need to detect and decontaminate critical facilities in the shortest possible time. There has been a remarkable progress in the detection, protection and decontamination of biological warfare agents as many instrumentation platforms and detection methodologies are developed and commissioned. Even then the threat of biological warfare agents and their use in bioterrorist attacks still remain a leading cause of global concern. Furthermore in the past decade there have been threats due to the emerging new diseases and also the re-emergence of old diseases and development of antimicrobial resistance and spread to new geographical regions. The preparedness against these agents need complete knowledge about the disease, better research and training facilities, diagnostic facilities and improved public health system. This review on the biological warfare agents will provide information on the biological warfare agents, their mode of transmission and spread and also the detection systems available to detect them. In addition the current information on the availability of commercially available and developing technologies against biological warfare agents has also been discussed. The risk that arise due to the use of these agents in warfare or bioterrorism related scenario can be mitigated with the availability of improved detection technologies.

  4. Information Complexity and Biology (United States)

    Bagnoli, Franco; Bignone, Franco A.; Cecconi, Fabio; Politi, Antonio

    Kolmogorov contributed directly to Biology in essentially three problems: the analysis of population dynamics (Lotka-Volterra equations), the reaction-diffusion formulation of gene spreading (FKPP equation), and some discussions about Mendel's laws. However, the widely recognized importance of his contribution arises from his work on algorithmic complexity. In fact, the limited direct intervention in Biology reflects the generally slow growth of interest of mathematicians towards biological issues. From the early work of Vito Volterra on species competition, to the slow growth of dynamical systems theory, contributions to the study of matter and the physiology of the nervous system, the first 50-60 years have witnessed important contributions, but as scattered pieces apparently uncorrelated, and in branches often far away from Biology. Up to the 40' it is hard to see the initial loose build up of a convergence, for those theories that will become mainstream research by the end of the century, and connected by the study of biological systems per-se.

  5. Fostering synergy between cell biology and systems biology



    In the shared pursuit of elucidating detailed mechanisms of cell function, systems biology presents a natural complement to ongoing efforts in cell biology. Systems biology aims to characterize biological systems through integrated and quantitative modeling of cellular information. The process of model building and analysis provides value through synthesizing and cataloging information about cells and molecules; predicting mechanisms and identifying generalizable themes; generating hypotheses...

  6. Informing biological design by integration of systems and synthetic biology. (United States)

    Smolke, Christina D; Silver, Pamela A


    Synthetic biology aims to make the engineering of biology faster and more predictable. In contrast, systems biology focuses on the interaction of myriad components and how these give rise to the dynamic and complex behavior of biological systems. Here, we examine the synergies between these two fields.

  7. Biological applications of nanobiotechnology. (United States)

    de Morais, Michele Greque; Martins, Vilásia Guimarães; Steffens, Daniela; Pranke, Patricia; da Costa, Jorge Alberto Vieira


    Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices derived from engineering, physics, chemistry, and biology. Nanotechnology has opened up by rapid advances in science and technology, creating new opportunities for advances in the fields of medicine, electronics, foods, and the environment. Nanoscale structures and materials (nanoparticles, nanowires, nanofibers, nanotubes) have been explored in many biological applications (biosensing, biological separation, molecular imaging, anticancer therapy) because their novel properties and functions differ drastically from their bulk counterparts. Their high volume/surface ratio, improved solubility, and multifunctionality open many new possibilities. The objective of this review is to describe the potential benefits and impacts of the nanobiotechnology in different areas.

  8. Epigenetics: Biology's Quantum Mechanics

    Directory of Open Access Journals (Sweden)

    Richard A Jorgensen


    Full Text Available The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920's and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of two views of the gene - the molecular biological view and the epigenetic view - are explored, and it is argued that the classical molecular biological view is incomplete without incorporation of the epigenetic perspective and that in a sense the molecular biological view has been evolving to include the epigenetic view. Intriguingly, this evolution of the molecular view toward the broader and more inclusive epigenetic view of the gene has an intriguing, if not precise, parallel in the evolution of concepts of atomic physics from Newtonian mechanics to quantum mechanics that are interesting to consider.

  9. Epigenetics: Biology's Quantum Mechanics. (United States)

    Jorgensen, Richard A


    The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of two views of the gene - the molecular biological view and the epigenetic view - are explored, and it is argued that the classical molecular biological view is incomplete without incorporation of the epigenetic perspective and that in a sense the molecular biological view has been evolving to include the epigenetic view. Intriguingly, this evolution of the molecular view toward the broader and more inclusive epigenetic view of the gene has an intriguing, if not precise, parallel in the evolution of concepts of atomic physics from Newtonian mechanics to quantum mechanics that are interesting to consider.

  10. Nutritional Systems Biology

    DEFF Research Database (Denmark)

    Jensen, Kasper

    sites of diet on the disease pathway. We propose a framework for interrogating the critical targets in colon cancer process and identifying plant-based dietary interventions as important modifiers using a systems chemical biology approach. The fifth chapter of the thesis is on discovering of novel anti...... number of thoroughly selected targets. Our need for fundamental understanding of the building blocks of the complex biological systems had been the main reason for the reductionist approach that was mainly applied in the past to elucidate these systems. Nowadays, it is widely recognized that systems...... components with biological systems and their connection to health and disease. The database will be enriched with predicted interactions between food components and protein targets, based on their structural and pharmacophore similarity with known small molecule ligands. Further to this, the associations...

  11. [Biologics in SLE]. (United States)

    Karonitsch, Thomas; Aringer, Martin


    Biologics have become indispensable in the last decade in the treatment of the more common rheumatic diseases. For treating systemic lupus erythematodes (SLE), B-cell depletion, albeit off-label, has been a well-accepted strategy in severe and refractory disease. Unexpectedly, however, the results of the first randomized controlled rituximab trials in SLE were negative. New trials with improved study protocols are ongoing, which should resolve this issue. In 2012, with the approval of belimumab, SLE finally entered the era of approved biological therapies. The anti-Blys/BAFF antibody belimumab showed prevention of SLE flares, glucocorticoid sparing, and significant improvement in the quality of life of SLE patients, in part by drastically reducing immune complex mediated fatigue. Positive reports on further targeting approaches give hope that additional biological agents will be available for SLE therapy soon.

  12. Biological therapy of psoriasis

    Directory of Open Access Journals (Sweden)

    Sivamani Raja


    Full Text Available The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF-α agents have been associated with a variety of serious and "routine" opportunistic infections.

  13. Biological Soft Robotics. (United States)

    Feinberg, Adam W


    In nature, nanometer-scale molecular motors are used to generate force within cells for diverse processes from transcription and transport to muscle contraction. This adaptability and scalability across wide temporal, spatial, and force regimes have spurred the development of biological soft robotic systems that seek to mimic and extend these capabilities. This review describes how molecular motors are hierarchically organized into larger-scale structures in order to provide a basic understanding of how these systems work in nature and the complexity and functionality we hope to replicate in biological soft robotics. These span the subcellular scale to macroscale, and this article focuses on the integration of biological components with synthetic materials, coupled with bioinspired robotic design. Key examples include nanoscale molecular motor-powered actuators, microscale bacteria-controlled devices, and macroscale muscle-powered robots that grasp, walk, and swim. Finally, the current challenges and future opportunities in the field are addressed.

  14. Biological therapy and dentistry (United States)

    Radfar, Lida; Ahmadabadi, Roshanak E; Masood, Farah; Scofield, R Hal


    In recent years, a new class of drugs has revolutionized the treatment of autoimmune, allergic, infectious and many more diseases. These drugs are classified into three groups, cytokines, monoclonal antibodies and fusion proteins. Biological drugs have less side effects compared to conventional drugs, and may target special damaged cells, but not all the cells. There may be side effects such as infection, hypersensitivity, hematological disorders, cancer, hepatotoxicity and neurological disorders, but there is not enough evidence or long term studies of the mechanism of action and side effects of these drugs. Patients on biological therapy may need some special consideration in dentistry. This paper is a review regarding the classification, mechanism of action and side effects of these drugs, and dental consideration for patients on biological therapy. PMID:26372436

  15. The biology of personality. (United States)

    Mulder, R


    Historically, models of personality have generally postulated, or assumed, a link with biology. This century has witnessed a major revision of these ideas with both behavioural and psychoanalytic theorists emphasising life experiences as being largely responsible for behaviour as adults. Challenges to this assumption of the overwhelming importance of life experiences are reviewed. An extensive body of data now exists suggesting that biology contributes significantly to individual variability. This biological contribution occurs at a relatively low level in the central nervous system, best defined as temperament. Further research has suffered from the lack of a cohesive psychobiological model. Cloninger's tridimensional theory of personality is presented as a model which attempts to bridge the gap between theoretical temperamental traits, neurotransmitter function and clinical psychiatry. It is to be hoped that new theoretical models will be formulated which will focus on the importance of temperamental variables in psychiatric disorders.

  16. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Galitski, Timothy P.


    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  17. [Cybernetics and biology]. (United States)

    Vasil'ev, G F


    Owing to methodical disadvantages, the theory of control still lacks the potential for the analysis of biological systems. To get the full benefit of the method in addition to the algorithmic model of control (as of today the only used model in the theory of control) a parametric model of control is offered to employ. The reasoning for it is explained. The approach suggested provides the possibility to use all potential of the modern theory of control for the analysis of biological systems. The cybernetic approach is shown taking a system of the rise of glucose concentration in blood as an example.

  18. PAC research in biology

    Energy Technology Data Exchange (ETDEWEB)

    Chain, C. Y., E-mail: [Universidad Nacional de La Plata, IFLP (Argentina); Ceolin, M. [Instituto de Investigaciones Fisicoquimicas Teoricas y Aplicadas, Dto de Quimica, Fac. Cs. Exactas, UNLP (Argentina); Pasquevich, A. F. [Universidad Nacional de La Plata, IFLP (Argentina)


    In this paper possible applications of the Perturbed Angular Correlations (PAC) technique in Biology are considered. Previous PAC experiments in biology are globally analyzed. All the work that appears in the literature has been grouped in a few research lines, just to make the analysis and discussion easy. The commonly used radioactive probes are listed and the experimental difficulties are analyzed. We also report applications of {sup 181}Hf and {sup 111}In isotopes in life sciences other than their use in PAC. The possibility of extending these studies using the PAC technique is discussed.

  19. Biological and Pharmaceutical Nanomaterials (United States)

    Kumar, Challa S. S. R.


    This first comprehensive yet concise overview of all important classes of biological and pharmaceutical nanomaterials presents in one volume the different kinds of natural biological compounds that form nanomaterials or that may be used to purposefully create them. This unique single source of information brings together the many articles published in specialized journals, which often remain unseen by members of other, related disciplines. Covering pharmaceutical, nucleic acid, peptide and DNA-Chitosan nanoparticles, the book focuses on those innovative materials and technologies needed for the continued growth of medicine, healthcare, pharmaceuticals and human wellness. For chemists, biochemists, cell biologists, materials scientists, biologists, and those working in the pharmaceutical and chemical industries.

  20. Systems biology in animal sciences

    NARCIS (Netherlands)

    Woelders, H.; Pas, te M.F.W.; Bannink, A.; Veerkamp, R.F.; Smits, M.A.


    Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes an

  1. Plant Systems Biology (editorial) (United States)

    In June 2003, Plant Physiology published an Arabidopsis special issue devoted to plant systems biology. The intention of Natasha Raikhel and Gloria Coruzzi, the two editors of this first-of-its-kind issue, was ‘‘to help nucleate this new effort within the plant community’’ as they considered that ‘‘...

  2. Evolution, Entropy, & Biological Information (United States)

    Peterson, Jacob


    A logical question to be expected from students: "How could life develop, that is, change, evolve from simple, primitive organisms into the complex forms existing today, while at the same time there is a generally observed decline and disorganization--the second law of thermodynamics?" The explanations in biology textbooks relied upon by…

  3. Doublethink in Biological Education (United States)

    Cox, Donald D.


    Presents the material given in a talk at the 1974 convention of the National Science Teachers Association in which the author compares practices in biology education to George Orwell's concept of "doublethink," i.e., the ability to hold two contradictory beliefs in one's mind simultaneously and to accept both of them. Developments in curriculum…

  4. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Goncalo Espregueira Cruz;


    As sequencing technologies become more affordable, it is now realistic to propose studying the evolutionary history of virtually any organism on a genomic scale. However, when dealing with non-model organisms it is not always easy to choose the best approach given a specific biological question, ...

  5. Openers for Biology Classes. (United States)

    Gridley, C. Robert R.

    This teaching guide contains 200 activities that are suitable for openers and demonstrations in biology classes. Details are provided regarding the use of these activities. Some of the broad topics under which the activities are organized include algae, amphibians, bacteria, biologists, crustaceans, dinosaurs, ecology, evolution, flowering plants,…

  6. Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Dev Vrat Kamboj


    Full Text Available There is a long historic record of use of biological warfare (BW agents by warring countriesagainst their enemies. However, the frequency of their use has increased since the beginningof the twentieth century. World war I witnessed the use of anthrax agent against human beingsand animals by Germans, followed by large-scale field trials by Japanese against war prisonersand Chinese population during world war II. Ironically, research and development in biologicalwarfare agents increased tremendously after the Geneva Protocol, signed in 1925, because ofits drawbacks which were overcome by Biological and Toxin Weapons Convention (BTWC in1972. Biological warfare programme took back seat after the 1972 convention but biologicalagents regained their importance after the bioterrorist attacks of anthrax powder in 2001. In thelight of these attacks, many of which turned out to be hoax, general awareness is required aboutbiological warfare agents that can be used against them. This review has been written highlightingimportant biological warfare agents, diseases caused by them, possible therapies and otherprotection measures.

  7. Diversity in Biological Molecules (United States)

    Newbury, H. John


    One of the striking characteristics of fundamental biological processes, such as genetic inheritance, development and primary metabolism, is the limited amount of variation in the molecules involved. Natural selective pressures act strongly on these core processes and individuals carrying mutations and producing slightly sub-optimal versions of…

  8. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Goncalo Espregueira Cruz


    we present an overview of the current sequencing technologies and the methods used in typical high-throughput data analysis pipelines. Subsequently, we contextualize high-throughput DNA sequencing technologies within their applications in non-model organism biology. We include tips regarding managing...

  9. Bayes in biological anthropology. (United States)

    Konigsberg, Lyle W; Frankenberg, Susan R


    In this article, we both contend and illustrate that biological anthropologists, particularly in the Americas, often think like Bayesians but act like frequentists when it comes to analyzing a wide variety of data. In other words, while our research goals and perspectives are rooted in probabilistic thinking and rest on prior knowledge, we often proceed to use statistical hypothesis tests and confidence interval methods unrelated (or tenuously related) to the research questions of interest. We advocate for applying Bayesian analyses to a number of different bioanthropological questions, especially since many of the programming and computational challenges to doing so have been overcome in the past two decades. To facilitate such applications, this article explains Bayesian principles and concepts, and provides concrete examples of Bayesian computer simulations and statistics that address questions relevant to biological anthropology, focusing particularly on bioarchaeology and forensic anthropology. It also simultaneously reviews the use of Bayesian methods and inference within the discipline to date. This article is intended to act as primer to Bayesian methods and inference in biological anthropology, explaining the relationships of various methods to likelihoods or probabilities and to classical statistical models. Our contention is not that traditional frequentist statistics should be rejected outright, but that there are many situations where biological anthropology is better served by taking a Bayesian approach. To this end it is hoped that the examples provided in this article will assist researchers in choosing from among the broad array of statistical methods currently available.

  10. Antiprotons get biological

    CERN Multimedia


    After its final run in September, the first results of the Antiproton Cell Experiment (ACE) look very promising. It was the first experiment to take data on the biological effects of antiproton beams to evaluate the potential of antiprotons in radiation therapy.

  11. Biology Curriculum Support Document. (United States)

    North Carolina Dept. of Public Instruction, Raleigh.

    This biology curriculum supplement includes the North Carolina Standard Course of Study Goals, helpful resources, and suggested activities supported by inquiry-based laboratory activities. Contents include a detailed description of content which provides the goals and standards being sough), a materials list for inquiry support labs and…

  12. Biological Isolation Garment (United States)


    A spinoff of astronaut's biological garment will allow hospital patients who are highly vulnerable to infection to leave their sterile habitats for several hours, carrying their germ free environment with them. Garments can be used in any of some 200 hospitals where isolation rooms are installed to treat leukemia.

  13. Commercializing Biological Control (United States)

    LeLeu, K. L.; Young, M. A.


    Describes the only commercial establishment involved in biological control in Australia. The wasp Aphitis melinus, which parasitizes the insect Red Scale, is bred in large numbers and released in the citrus groves where Red Scale is causing damage to the fruit. (JR)

  14. Biological trade and markets. (United States)

    Hammerstein, Peter; Noë, Ronald


    Cooperation between organisms can often be understood, like trade between merchants, as a mutually beneficial exchange of services, resources or other 'commodities'. Mutual benefits alone, however, are not sufficient to explain the evolution of trade-based cooperation. First, organisms may reject a particular trade if another partner offers a better deal. Second, while human trade often entails binding contracts, non-human trade requires unwritten 'terms of contract' that 'self-stabilize' trade and prevent cheating even if all traders strive to maximize fitness. Whenever trading partners can be chosen, market-like situations arise in nature that biologists studying cooperation need to account for. The mere possibility of exerting partner choice stabilizes many forms of otherwise cheatable trade, induces competition, facilitates the evolution of specialization and often leads to intricate forms of cooperation. We discuss selected examples to illustrate these general points and review basic conceptual approaches that are important in the theory of biological trade and markets. Comparing these approaches with theory in economics, it turns out that conventional models-often called 'Walrasian' markets-are of limited relevance to biology. In contrast, early approaches to trade and markets, as found in the works of Ricardo and Cournot, contain elements of thought that have inspired useful models in biology. For example, the concept of comparative advantage has biological applications in trade, signalling and ecological competition. We also see convergence between post-Walrasian economics and biological markets. For example, both economists and biologists are studying 'principal-agent' problems with principals offering jobs to agents without being sure that the agents will do a proper job. Finally, we show that mating markets have many peculiarities not shared with conventional economic markets. Ideas from economics are useful for biologists studying cooperation but need

  15. Systems biology, emergence and antireductionism. (United States)

    Kesić, Srdjan


    This study explores the conceptual history of systems biology and its impact on philosophical and scientific conceptions of reductionism, antireductionism and emergence. Development of systems biology at the beginning of 21st century transformed biological science. Systems biology is a new holistic approach or strategy how to research biological organisms, developed through three phases. The first phase was completed when molecular biology transformed into systems molecular biology. Prior to the second phase, convergence between applied general systems theory and nonlinear dynamics took place, hence allowing the formation of systems mathematical biology. The second phase happened when systems molecular biology and systems mathematical biology, together, were applied for analysis of biological data. Finally, after successful application in science, medicine and biotechnology, the process of the formation of modern systems biology was completed. Systems and molecular reductionist views on organisms were completely opposed to each other. Implications of systems and molecular biology on reductionist-antireductionist debate were quite different. The analysis of reductionism, antireductionism and emergence issues, in the era of systems biology, revealed the hierarchy between methodological, epistemological and ontological antireductionism. Primarily, methodological antireductionism followed from the systems biology. Only after, epistemological and ontological antireductionism could be supported.

  16. Aluminium nitrate ceramics: A potential UV dosemeter material

    DEFF Research Database (Denmark)

    Trinkler, L.; Bøtter-Jensen, L.; Berzina, B.


    dosimetry applications. The features are: (1) the spectral sensitivity covers the 200-350 nm range, in the UV-B region it is similar to that of human skin: (2) the angular dependence of the incident radiation follows the cosine law; (3) high yields of both UVR-induced OSL and TL signals compared to those...

  17. Multisphere neutron spectrometric system with thermoluminescence dosemeters: sensitive improvement. (United States)

    Gregori, B; Papadópulos, S; Cruzate, J; Kunst, J J


    In this work, a neutron spectrometric system based on a set of moderating spheres with thermoluminescence detectors (TLD) is presented. The system at the Nuclear Regulatory Authority (ARN) Dosimetry Laboratory consists of 12 solid spheres made of high-density polyethylene (p = 0.95 g x cm(-3)), with diameters ranging from 2" to 12" and TLD sensitive to thermal and gamma radiation, namely TLD-600 and TLD-700, located at the centre of the spheres. The neutron response matrix for this Bonner Sphere Spectrometer (BSS) was calculated using the MCNP-IVB code and the library ENDF/B-VI in the energy range between thermal neutrons and 100 MeV. The neutron spectrum was obtained using the LOUH182 unfolding code. The improvement in sensitivity of the system is based on the election of a different heating cycle of the TLD that allows an increase in sensitivity by a factor of 2.6 compared with the standard laboratory treatment. The system response for the calibration with an Am-Be source is presented.

  18. Quantum physics meets biology

    CERN Document Server

    Arndt, Markus; Vedral, Vlatko


    Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the last decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world view of quantum coherences, entanglement and other non-classical effects, has been heading towards systems of increasing complexity. The present perspective article shall serve as a pedestrian guide to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future quantum biology, its current status, recent experimental progress and also the restrictions that nature imposes on bold extrapolat...

  19. [Cell biology and cosmetology]. (United States)

    Traniello, S; Cavalletti, T


    Cellular biology can become the natural support of research in the field of cosmetics because it is able to provide alternative experimental models which can partially replace the massive use of laboratory animals. Cultures of human skin cells could be used in tests investigating irritation of the skin. We have developed an "in vitro" experimental model that allows to evaluate the damage caused by the free radicals to the fibroblasts in culture and to test the protective action of the lipoaminoacids. Experimenting on human cell cultures presents the advantage of eliminating the extrapolation between the different species, of allowing a determination of the biological action of a substance and of evaluating its dose/response effect. This does not mean that "in vitro" experimenting could completely replace experimenting on living animals, but the "in vitro" model can be introduced in the realisation of preliminary screenings.

  20. Biological scaling and physics

    Indian Academy of Sciences (India)

    A R P Rau


    Kleiber’s law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as -1/4 in terms of the mass of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  1. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Gonçalo Espregueira;


    we present an overview of the current sequencing technologies and the methods used in typical high-throughput data analysis pipelines. Subsequently, we contextualize high-throughput DNA sequencing technologies within their applications in non-model organism biology. We include tips regarding managing......As sequencing technologies become more affordable, it is now realistic to propose studying the evolutionary history of virtually any organism on a genomic scale. However, when dealing with non-model organisms it is not always easy to choose the best approach given a specific biological question......, a limited budget, and challenging sample material. Furthermore, although recent advances in technology offer unprecedented opportunities for research in non-model organisms, they also demand unprecedented awareness from the researcher regarding the assumptions and limitations of each method. In this review...

  2. Quantum physics meets biology. (United States)

    Arndt, Markus; Juffmann, Thomas; Vedral, Vlatko


    Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the past decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world-view of quantum coherences, entanglement, and other nonclassical effects, has been heading toward systems of increasing complexity. The present perspective article shall serve as a "pedestrian guide" to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future "quantum biology," its current status, recent experimental progress, and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.

  3. Biological scaling and physics. (United States)

    Rau, A R P


    Kleiber's law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as M- 1/4 in terms of the mass M of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  4. Heritability and biological explanation. (United States)

    Turkheimer, E


    Modern neuroscientific and genetic technologies have provoked intense disagreement between scientists who envision a future in which biogenetic theories will enrich or even replace psychological theories, and others who consider biogenetic theories exaggerated, dehumanizing, and dangerous. Both sides of the debate about the role of genes and brains in the genesis of human behavior have missed an important point: All human behavior that varies among individuals is partially heritable and correlated with measurable aspects of brains, but the very ubiquity of these findings makes them a poor basis for reformulating scientists' conceptions of human behavior. Materialism requires psychological processes to be physically instantiated, but more crucial for psychology is the occasional empirical discovery of behavioral phenomena that are specific manifestations of low-level biological variables. Heritability and psychobiological association cannot be the basis for establishing whether behavior is genetic or biological, because to do so leads only to the banal tautology that all behavior is ultimately based in the genotype and brain.

  5. Topology in Molecular Biology

    CERN Document Server

    Monastyrsky, Michail Ilych


    The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form.

  6. Traceability of biologicals

    DEFF Research Database (Denmark)

    Vermeer, Niels S; Spierings, Irina; Mantel-Teeuwisse, Aukje K


    not support the routine recording of batch information. Expected changes in supply chain standards provide opportunities to systematically record detailed exposure information. Spontaneous reporting systems are the most vulnerable link in ensuring traceability, due to the manual nature of data transfer...... individual products within pharmacovigilance databases. AREAS COVERED: The authors discuss the present challenges in the traceability of biologicals in relation to pharmacovigilance, by exploring the processes involved in ensuring traceability. They explore both the existing systems that are in place...

  7. Milli-Biology (United States)


    inefficient at low RPM because power is wasted as heat in the coils, requiring gearing at low RPM, and power is required to maintain static position...soldering to join metal parts, epoxy to join the heat -sensitive permanent magnets, and screws to reversibly fasten subassemblies that might require...aerospace, and heliostat pointing for solar power. These are now transitioning to commercial development. The milli-biology workflow for coded

  8. Menstrual Cycle: Basic Biology



    The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X premutations (Chapter X), X chromosome abnormalities (Chapter X), and galactose-1-phosphate uridyltransferase (GALT) point mutati...

  9. Biological Correlates of Empathy

    Directory of Open Access Journals (Sweden)

    E. Timucin Oral


    Full Text Available Empathy can be defined as the capacity to know emotionally what another is experiencing from within the frame of reference of that other person and the capacity to sample the feelings of another or it can be metaphorized as to put oneself in another’s shoes. Although the concept of empathy was firstly described in psychological theories, researches studying the biological correlates of psychological theories have been increasing recently. Not suprisingly, dinamically oriented psychotherapists Freud, Kohut, Basch and Fenichel had suggested theories about the biological correlates of empathy concept and established the basis of this modality decades ago. Some other theorists emphasized the importance of empathy in the early years of lifetime regarding mother-child attachment in terms of developmental psychology and investigated its role in explanation of psychopathology. The data coming from some of the recent brain imaging and animal model studies also seem to support these theories. Although increased activity in different brain regions was shown in many of the brain imaging studies, the role of cingulate cortex for understanding mother-child relationship was constantly emphasized in nearly all of the studies. In addition to these studies, a group of Italian scientists has defined a group of neurons as “mirror neurons” in their studies observing rhesus macaque monkeys. Later, they also defined mirror neurons in human studies, and suggested them as “empathy neurons”. After the discovery of mirror neurons, the hopes of finding the missing part of the puzzle for understanding the biological correlates of empathy raised again. Although the roles of different biological parameters such as skin conductance and pupil diameter for defining empathy have not been certain yet, they are going to give us the opportunity to revise the inconsistent basis of structural validity in psychiatry and to stabilize descriptive validity. In this review, the

  10. Biological therapies for spondyloarthritis


    Bruner, Vincenzo; Atteno, Mariangela; Spanò, Angelo; Scarpa, Raffaele; Peluso, Rosario


    Biological therapies and new imaging techniques have changed the therapeutic and diagnostic approach to spondyloarthritis. In patients with axial spondyloarthritis, tumor necrosis factor α (TNFα) inhibitor treatment is currently the only effective therapy in patients for whom conventional therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) has failed. TNFα inhibitor treatment is more effective in preventing articular damage in peripheral joints than in axial ones. It is important to tr...

  11. Dominating biological networks.

    Directory of Open Access Journals (Sweden)

    Tijana Milenković

    Full Text Available Proteins are essential macromolecules of life that carry out most cellular processes. Since proteins aggregate to perform function, and since protein-protein interaction (PPI networks model these aggregations, one would expect to uncover new biology from PPI network topology. Hence, using PPI networks to predict protein function and role of protein pathways in disease has received attention. A debate remains open about whether network properties of "biologically central (BC" genes (i.e., their protein products, such as those involved in aging, cancer, infectious diseases, or signaling and drug-targeted pathways, exhibit some topological centrality compared to the rest of the proteins in the human PPI network.To help resolve this debate, we design new network-based approaches and apply them to get new insight into biological function and disease. We hypothesize that BC genes have a topologically central (TC role in the human PPI network. We propose two different concepts of topological centrality. We design a new centrality measure to capture complex wirings of proteins in the network that identifies as TC those proteins that reside in dense extended network neighborhoods. Also, we use the notion of domination and find dominating sets (DSs in the PPI network, i.e., sets of proteins such that every protein is either in the DS or is a neighbor of the DS. Clearly, a DS has a TC role, as it enables efficient communication between different network parts. We find statistically significant enrichment in BC genes of TC nodes and outperform the existing methods indicating that genes involved in key biological processes occupy topologically complex and dense regions of the network and correspond to its "spine" that connects all other network parts and can thus pass cellular signals efficiently throughout the network. To our knowledge, this is the first study that explores domination in the context of PPI networks.

  12. Quantum Effects in Biology (United States)

    Mohseni, Masoud; Omar, Yasser; Engel, Gregory S.; Plenio, Martin B.


    List of contributors; Preface; Part I. Introduction: 1. Quantum biology: introduction Graham R. Fleming and Gregory D. Scholes; 2. Open quantum system approaches to biological systems Alireza Shabani, Masoud Mohseni, Seogjoo Jang, Akihito Ishizaki, Martin Plenio, Patrick Rebentrost, Alàn Aspuru-Guzik, Jianshu Cao, Seth Lloyd and Robert Silbey; 3. Generalized Förster resonance energy transfer Seogjoo Jang, Hoda Hossein-Nejad and Gregory D. Scholes; 4. Multidimensional electronic spectroscopy Tomáš Mančal; Part II. Quantum Effects in Bacterial Photosynthetic Energy Transfer: 5. Structure, function, and quantum dynamics of pigment protein complexes Ioan Kosztin and Klaus Schulten; 6. Direct observation of quantum coherence Gregory S. Engel; 7. Environment-assisted quantum transport Masoud Mohseni, Alàn Aspuru-Guzik, Patrick Rebentrost, Alireza Shabani, Seth Lloyd, Susana F. Huelga and Martin B. Plenio; Part III. Quantum Effects in Higher Organisms and Applications: 8. Excitation energy transfer in higher plants Elisabet Romero, Vladimir I. Novoderezhkin and Rienk van Grondelle; 9. Electron transfer in proteins Spiros S. Skourtis; 10. A chemical compass for bird navigation Ilia A. Solov'yov, Thorsten Ritz, Klaus Schulten and Peter J. Hore; 11. Quantum biology of retinal Klaus Schulten and Shigehiko Hayashi; 12. Quantum vibrational effects on sense of smell A. M. Stoneham, L. Turin, J. C. Brookes and A. P. Horsfield; 13. A perspective on possible manifestations of entanglement in biological systems Hans J. Briegel and Sandu Popescu; 14. Design and applications of bio-inspired quantum materials Mohan Sarovar, Dörthe M. Eisele and K. Birgitta Whaley; 15. Coherent excitons in carbon nanotubes Leonas Valkunas and Darius Abramavicius; Glossary; References; Index.

  13. Synthetic biology: advancing biological frontiers by building synthetic systems


    Chen, Yvonne Yu-Hsuan; Galloway, Kate E; Smolke, Christina D.


    Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy. We discuss the theoretical foundation, applications, and potential of this emerging field.

  14. Biological heart valves. (United States)

    Ciubotaru, Anatol; Cebotari, Serghei; Tudorache, Igor; Beckmann, Erik; Hilfiker, Andres; Haverich, Axel


    Cardiac valvular pathologies are often caused by rheumatic fever in young adults, atherosclerosis in elderly patients, or by congenital malformation of the heart in children, in effect affecting almost all population ages. Almost 300,000 heart valve operations are performed worldwide annually. Tissue valve prostheses have certain advantages over mechanical valves such as biocompatibility, more physiological hemodynamics, and no need for life-long systemic anticoagulation. However, the major disadvantage of biological valves is related to their durability. Nevertheless, during the last decade, the number of patients undergoing biological, rather than mechanical, valve replacement has increased from half to more than three-quarters for biological implants. Continuous improvement in valve fabrication includes development of new models and shapes, novel methods of tissue treatment, and preservation and implantation techniques. These efforts are focused not only on the improvement of morbidity and mortality of the patients but also on the improvement of their quality of life. Heart valve tissue engineering aims to provide durable, "autologous" valve prostheses. These valves demonstrate adaptive growth, which may avoid the need of repeated operations in growing patients.

  15. Absolute biological needs. (United States)

    McLeod, Stephen


    Absolute needs (as against instrumental needs) are independent of the ends, goals and purposes of personal agents. Against the view that the only needs are instrumental needs, David Wiggins and Garrett Thomson have defended absolute needs on the grounds that the verb 'need' has instrumental and absolute senses. While remaining neutral about it, this article does not adopt that approach. Instead, it suggests that there are absolute biological needs. The absolute nature of these needs is defended by appeal to: their objectivity (as against mind-dependence); the universality of the phenomenon of needing across the plant and animal kingdoms; the impossibility that biological needs depend wholly upon the exercise of the abilities characteristic of personal agency; the contention that the possession of biological needs is prior to the possession of the abilities characteristic of personal agency. Finally, three philosophical usages of 'normative' are distinguished. On two of these, to describe a phenomenon or claim as 'normative' is to describe it as value-dependent. A description of a phenomenon or claim as 'normative' in the third sense does not entail such value-dependency, though it leaves open the possibility that value depends upon the phenomenon or upon the truth of the claim. It is argued that while survival needs (or claims about them) may well be normative in this third sense, they are normative in neither of the first two. Thus, the idea of absolute need is not inherently normative in either of the first two senses.

  16. Biologics for tendon repair. (United States)

    Docheva, Denitsa; Müller, Sebastian A; Majewski, Martin; Evans, Christopher H


    Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly because these injuries often respond poorly to treatment and require prolonged rehabilitation. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts, and synthetic prostheses. To date, none of these alternatives has provided a successful long-term solution, and often the restored tendons do not recover their complete strength and functionality. Unfortunately, our understanding of tendon biology lags far behind that of other musculoskeletal tissues, thus impeding the development of new treatment options for tendon conditions. Hence, in this review, after introducing the clinical significance of tendon diseases and the present understanding of tendon biology, we describe and critically assess the current strategies for enhancing tendon repair by biological means. These consist mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage. A deeper understanding of how tendon tissue and cells operate, combined with practical applications of modern molecular and cellular tools could provide the long awaited breakthrough in designing effective tendon-specific therapeutics and overall improvement of tendon disease management.

  17. Biological surface science (United States)

    Kasemo, Bengt


    Biological surface science (BioSS), as defined here is the broad interdisciplinary area where properties and processes at interfaces between synthetic materials and biological environments are investigated and biofunctional surfaces are fabricated. Six examples are used to introduce and discuss the subject: Medical implants in the human body, biosensors and biochips for diagnostics, tissue engineering, bioelectronics, artificial photosynthesis, and biomimetic materials. They are areas of varying maturity, together constituting a strong driving force for the current rapid development of BioSS. The second driving force is the purely scientific challenges and opportunities to explore the mutual interaction between biological components and surfaces. Model systems range from the unique water structures at solid surfaces and water shells around proteins and biomembranes, via amino and nucleic acids, proteins, DNA, phospholipid membranes, to cells and living tissue at surfaces. At one end of the spectrum the scientific challenge is to map out the structures, bonding, dynamics and kinetics of biomolecules at surfaces in a similar way as has been done for simple molecules during the past three decades in surface science. At the other end of the complexity spectrum one addresses how biofunctional surfaces participate in and can be designed to constructively participate in the total communication system of cells and tissue. Biofunctional surfaces call for advanced design and preparation in order to match the sophisticated (bio) recognition ability of biological systems. Specifically this requires combined topographic, chemical and visco-elastic patterns on surfaces to match proteins at the nm scale and cells at the micrometer scale. Essentially all methods of surface science are useful. High-resolution (e.g. scanning probe) microscopies, spatially resolved and high sensitivity, non-invasive optical spectroscopies, self-organizing monolayers, and nano- and microfabrication

  18. Molecular Biology of Nitrogen Fixation (United States)

    Shanmugam, K. T.; Valentine, Raymond C.


    Reports that as a result of our increasing knowledge of the molecular biology of nitrogen fixation it might eventually be possible to increase the biological production of nitrogenous fertilizer from atmospheric nitrogen. (GS)

  19. Is Our Biology to Blame? (United States)

    Schneider, Scott


    Brief analyses of three recent examples of biological determinism: sex roles, overpopulation, and sociobiology, are presented in this article. Also a brief discussion of biological determinism and education is presented. (MR)

  20. Logical analysis of biological systems

    DEFF Research Database (Denmark)

    Mardare, Radu Iulian


    R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005.......R. Mardare, Logical analysis of biological systems. Fundamenta Informaticae, N 64:271-285, 2005....

  1. Biological treatment of Crohn's disease

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; Bjerrum, Jacob Tveiten; Seidelin, Jakob Benedict


    Introduction of biological agents for the treatment of Crohn's disease (CD) has led to a transformation of the treatment paradigm. Several biological compounds have been approved for patients with CD refractory to conventional treatment: infliximab, adalimumab and certolizumab pegol (and...

  2. Logical impossibilities in biological networks

    Directory of Open Access Journals (Sweden)

    Monendra Grover


    Full Text Available Biological networks are complex and involve several kinds of molecules. For proper biological function it is important for these biomolecules to act at an individual level and act at the level of interaction of these molecules. In this paper some of the logical impossibilities that may arise in the biological networks and their possible solutions are discussed. It may be important to understand these paradoxes and their possible solutions in order to develop a holistic view of biological function.

  3. Biological Computing Fundamentals and Futures


    Akula, Balaji; Cusick, James


    The fields of computing and biology have begun to cross paths in new ways. In this paper a review of the current research in biological computing is presented. Fundamental concepts are introduced and these foundational elements are explored to discuss the possibilities of a new computing paradigm. We assume the reader to possess a basic knowledge of Biology and Computer Science

  4. Functions in Biological Kind Classification (United States)

    Lombrozo, Tania; Rehder, Bob


    Biological traits that serve functions, such as a zebra's coloration (for camouflage) or a kangaroo's tail (for balance), seem to have a special role in conceptual representations for biological kinds. In five experiments, we investigate whether and why functional features are privileged in biological kind classification. Experiment 1…

  5. Semiconductor nanostructures in biological applications

    Energy Technology Data Exchange (ETDEWEB)

    Alexson, Dimitri [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Chen Hongfeng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Cho, Michael [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Dutta, Mitra [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Li Yang [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Shi, Peng [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Raichura, Amit [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Ramadurai, Dinakar [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Parikh, Shaunak [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Stroscio, Michael A [Department of Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607 (United States); Department of Physics, University of Illinois at Chicago, Chicago, IL 60607 (United States); Vasudev, Milana [Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 (United States)


    Semiconductor nanostructures in biological applications are discussed. Results are presented on the use of colloidal semiconductor quantum dots both as biological tags and as structures that interact with and influence biomolecules. Results are presented on the use of semiconducting carbon nanotubes in biological applications. (topical review)


    Directory of Open Access Journals (Sweden)

    T. I. Burak


    Full Text Available The methodology for computer modeling of complex eco-biological models is presented in this paper. It is based on system approach of J. Forrester. Developed methodology is universal for complex ecological and biological systems. Modeling algorithm considers specialties of eco-biological systems and shows adequate and accurate results in practice. 

  7. Marine molecular biology: an emerging field of biological sciences. (United States)

    Thakur, Narsinh L; Jain, Roopesh; Natalio, Filipe; Hamer, Bojan; Thakur, Archana N; Müller, Werner E G


    An appreciation of the potential applications of molecular biology is of growing importance in many areas of life sciences, including marine biology. During the past two decades, the development of sophisticated molecular technologies and instruments for biomedical research has resulted in significant advances in the biological sciences. However, the value of molecular techniques for addressing problems in marine biology has only recently begun to be cherished. It has been proven that the exploitation of molecular biological techniques will allow difficult research questions about marine organisms and ocean processes to be addressed. Marine molecular biology is a discipline, which strives to define and solve the problems regarding the sustainable exploration of marine life for human health and welfare, through the cooperation between scientists working in marine biology, molecular biology, microbiology and chemistry disciplines. Several success stories of the applications of molecular techniques in the field of marine biology are guiding further research in this area. In this review different molecular techniques are discussed, which have application in marine microbiology, marine invertebrate biology, marine ecology, marine natural products, material sciences, fisheries, conservation and bio-invasion etc. In summary, if marine biologists and molecular biologists continue to work towards strong partnership during the next decade and recognize intellectual and technological advantages and benefits of such partnership, an exciting new frontier of marine molecular biology will emerge in the future.

  8. NASA Biological Specimen Repository (United States)

    McMonigal, K. A.; Pietrzyk, R. A.; Sams, C. F.; Johnson, M. A.


    The NASA Biological Specimen Repository (NBSR) was established in 2006 to collect, process, preserve and distribute spaceflight-related biological specimens from long duration ISS astronauts. This repository provides unique opportunities to study longitudinal changes in human physiology spanning may missions. The NBSR collects blood and urine samples from all participating ISS crewmembers who have provided informed consent. These biological samples are collected once before flight, during flight scheduled on flight days 15, 30, 60, 120 and within 2 weeks of landing. Postflight sessions are conducted 3 and 30 days after landing. The number of in-flight sessions is dependent on the duration of the mission. Specimens are maintained under optimal storage conditions in a manner that will maximize their integrity and viability for future research The repository operates under the authority of the NASA/JSC Committee for the Protection of Human Subjects to support scientific discovery that contributes to our fundamental knowledge in the area of human physiological changes and adaptation to a microgravity environment. The NBSR will institute guidelines for the solicitation, review and sample distribution process through establishment of the NBSR Advisory Board. The Advisory Board will be composed of representatives of all participating space agencies to evaluate each request from investigators for use of the samples. This process will be consistent with ethical principles, protection of crewmember confidentiality, prevailing laws and regulations, intellectual property policies, and consent form language. Operations supporting the NBSR are scheduled to continue until the end of U.S. presence on the ISS. Sample distribution is proposed to begin with selections on investigations beginning in 2017. The availability of the NBSR will contribute to the body of knowledge about the diverse factors of spaceflight on human physiology.

  9. Biology Reflective Assessment Curriculum (United States)

    Bayley, Cheryl Ann

    Often students and educators view assessments as an obligation and finality for a unit. In the current climate of high-stakes testing and accountability, the balance of time, resources and emphasis on students' scores related to assessment have been slanted considerably toward the summative side. This tension between assessment for accountability and assessment to inform teaching strains instruction and educators' ability to use that information to design learning opportunities that help students develop deeper conceptual understanding. A substantive body of research indicates that formative and reflective assessment can significantly improve student learning. Biology Reflective Assessment Curriculum (BRAC) examines support provided for high school science students through assessment practices. This investigation incorporates the usage of reflective assessments as a guiding practice for differentiated instruction and student choice. Reflective assessment is a metacognitive strategy that promotes self-monitoring and evaluation. The goals of the curriculum are to promote self-efficacy and conceptual understanding in students learning biology through developing their metacognitive awareness. BRAC was implemented in a high school biology classroom. Data from assessments, metacognitive surveys, self-efficacy surveys, reflective journals, student work, a culminating task and field notes were used to evaluate the effectiveness of the curriculum. The results suggest that students who develop their metacognitive skills developed a deeper conceptual understanding and improved feelings of self-efficacy when they were engaged in a reflective assessment unit embedded with student choice. BRAC is a tool for teachers to use assessments to assist students in becoming metacognitive and to guide student choice in learning opportunities.

  10. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun


    commitments with differently imagined futures. I argue that promises are constitutive of the stem cell biology, rather than being derivative of it. Since the biological concept of stem cells is predicated on the future that they promise, the biological life of stem cells is inextricably intertwined...... patients’ bodies in anticipation of materializing the promises of stem cell biology, they are produced as a new form of biovaluable. The promises of biology move beyond the closed circuit of scientific knowledge production, and proliferate in the speculative marketplaces of promises. Part II looks at how...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  11. Illuminating Cell Biology (United States)


    NASA's Ames Research Center awarded Ciencia, Inc., a Small Business Innovation Research contract to develop the Cell Fluorescence Analysis System (CFAS) to address the size, mass, and power constraints of using fluorescence spectroscopy in the International Space Station's Life Science Research Facility. The system will play an important role in studying biological specimen's long-term adaptation to microgravity. Commercial applications for the technology include diverse markets such as food safety, in situ environmental monitoring, online process analysis, genomics and DNA chips, and non-invasive diagnostics. Ciencia has already sold the system to the private sector for biosensor applications.

  12. Biological hydrogen production

    Energy Technology Data Exchange (ETDEWEB)

    Benemann, J.R. [Univ. of California, Berkeley, CA (United States)


    Biological hydrogen production can be accomplished by either thermochemical (gasification) conversion of woody biomass and agricultural residues or by microbiological processes that yield hydrogen gas from organic wastes or water. Biomass gasification is a well established technology; however, the synthesis gas produced, a mixture of CO and H{sub 2}, requires a shift reaction to convert the CO to H{sub 2}. Microbiological processes can carry out this reaction more efficiently than conventional catalysts, and may be more appropriate for the relatively small-scale of biomass gasification processes. Development of a microbial shift reaction may be a near-term practical application of microbial hydrogen production.

  13. Biological Petri Nets

    CERN Document Server

    Wingender, E


    It was suggested some years ago that Petri nets might be well suited to modeling metabolic networks, overcoming some of the limitations encountered by the use of systems employing ODEs (ordinary differential equations). Much work has been done since then which confirms this and demonstrates the usefulness of this concept for systems biology. Petri net technology is not only intuitively understood by scientists trained in the life sciences, it also has a robust mathematical foundation and provides the required degree of flexibility. As a result it appears to be a very promising approach to mode

  14. Systems biology: experimental design. (United States)

    Kreutz, Clemens; Timmer, Jens


    Experimental design has a long tradition in statistics, engineering and life sciences, dating back to the beginning of the last century when optimal designs for industrial and agricultural trials were considered. In cell biology, the use of mathematical modeling approaches raises new demands on experimental planning. A maximum informative investigation of the dynamic behavior of cellular systems is achieved by an optimal combination of stimulations and observations over time. In this minireview, the existing approaches concerning this optimization for parameter estimation and model discrimination are summarized. Furthermore, the relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed.

  15. Biology of Nanobots (United States)

    Duan, Wentao; Pavlick, Ryan; Sen, Ayusman


    One of the more interesting recent discoveries has been the ability to design nano/microbots which catalytically harness the chemical energy in their environment to move autonomously. Their potential applications include delivery of materials, self-assembly of superstructures, and roving sensors. One emergent area of research is the study of their collective behavior and how they emulate living systems. The aim of this chapter is to describe the "biology" of nanobots, summarizing the fundamentals physics behind their motion and how the bots interact with each other to initiate complex emergent behavior.

  16. Menstrual Cycle: Basic Biology (United States)

    Hawkins, Shannon M.; Matzuk, Martin M.


    The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X premutations (Chapter X), X chromosome abnormalities (Chapter X), and galactose-1-phosphate uridyltransferase (GALT) point mutations (galactosemia) also contribute to perturbations of the menstrual cycle. Although not perfect, mouse model have helped to identify and confirm additional components and pathways in menstrual cycle function and dysfunction in humans. PMID:18574203

  17. [Tuberculosis and molecular biology]. (United States)

    Andersen, Ase Bengård; Lillebaek, Troels; Søborg, Christian; Johansen, Isik Somuncu; Thomsen, Vibeke Østergaard


    Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) hunting millions worldwide, is a challenge to work with in the laboratory. Modern molecular biology has provided extremely useful tools which have changed conventional diagnostic procedures in the TB laboratories. Research in molecular epidemiology is currently expanding our knowledge of the natural history of TB. Access to the genome sequence has opened new avenues for research in drug development and new vaccines. However, we are still awaiting the impact of these efforts in the resource-poor TB endemic countries.

  18. Biology of Bilirubin Photoisomers. (United States)

    Hansen, Thor Willy Ruud


    Phototherapy is the main treatment for neonatal hyperbilirubinemia. In acute treatment of extreme hyperbilirubinemia, intensive phototherapy may have a role in 'detoxifying' the bilirubin molecule to more polar photoisomers, which should be less prone to crossing the blood-brain barrier, providing a 'brain-sparing' effect. This article reviews the biology of bilirubin isomers. Although there is evidence supporting the lower toxicity of bilirubin photoisomers, there are studies showing the opposite. There are methodologic weaknesses in most studies and better-designed experiments are needed. In an infant acutely threatened by bilirubin-induced brain damage, intensified phototherapy should be used expediently and aggressively.

  19. Nanoindentation of biological composites (United States)

    Dickinson, M.


    This investigation studied the effect of storage conditions on the mechanical properties as measured by nanoindentation of mineralised tissue samples. The three storage solutions were Hanks balanced salt solution, phosphate buffered saline and deionised water and all had a significant effect on the surface properties, namely hardness and modulus of enamel, dentin and bone tested. The effect was significant with a greater than 70% reduction in surface mechanical properties after 8 days immersion in the solutions. This study highlights the importance of testing biological tissues immediately after extraction, and the possible structural and chemistry changes that may occur by artificially storing the tissues.

  20. Opportunities in plant synthetic biology. (United States)

    Cook, Charis; Martin, Lisa; Bastow, Ruth


    Synthetic biology is an emerging field uniting scientists from all disciplines with the aim of designing or re-designing biological processes. Initially, synthetic biology breakthroughs came from microbiology, chemistry, physics, computer science, materials science, mathematics, and engineering disciplines. A transition to multicellular systems is the next logical step for synthetic biologists and plants will provide an ideal platform for this new phase of research. This meeting report highlights some of the exciting plant synthetic biology projects, and tools and resources, presented and discussed at the 2013 GARNet workshop on plant synthetic biology.

  1. [Biological activity of Spirulina]. (United States)

    Blinkova, L P; Gorobets, O B; Baturo, A P


    In this review information of Spirulina platensis (SP), a blue-green alga (photosynthesizing cyanobacterium) having diverse biological activity is presented. Due to high content of highly valuable proteins, indispensable amino acids, vitamins, beta-carotene and other pigments, mineral substances, indispensable fatty acids and polysaccharides, PS has been found suitable for use as bioactive additive. SP produces an immunostimulating effect by enhancing the resistance of humans, mammals, chickens and fish to infections, the capacity of influencing hemopoiesis, stimulating the production of antibodies and cytokines. Under the influence of SP macrophages, T and B cells are activated. SP sulfolipids have proved to be effective against HIV. Preparations obtained from SP biomass have also been found active against herpesvirus, cytomegalovirus, influenza virus, etc. SP extracts are capable in inhibiting cancerogenesis. SP preparations are regarded as functional products contributing to the preservation of the resident intestinal microflora, especially lactic acid bacilli and bifidobacteria, and to a decrease in the level of Candida albicans. The biological activity of SP with respect to microorganisms holds good promise for using these microalgae as components of culture media.

  2. Biological hydrogen photoproduction

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Y. [Univ. of Miami, FL (United States)


    Following are the major accomplishments of the 6th year`s study of biological hydrogen photoproduction which were supported by DOE/NREL. (1) We have been characterizing a biological hydrogen production system using synchronously growing aerobically nitrogen-fixing unicellular cyanobacterium, Synechococcus sp. Miami BG 043511. So far it was necessary to irradiate the cells to produce hydrogen. Under darkness they did not produce hydrogen. However, we found that, if the cells are incubated with oxygen, they produce hydrogen under the dark. Under 80% argon + 20% oxygen condition, the hydrogen production activity under the dark was about one third of that under the light + argon condition. (2) Also it was necessary so far to incubate the cells under argon atmosphere to produce hydrogen in this system. Argon treatment is very expensive and should be avoided in an actual hydrogen production system. We found that, if the cells are incubated at a high cell density and in a container with minimum headspace, it is not necessary to use argon for the hydrogen production. (3) Calcium ion was found to play an important role in the mechanisms of protection of nitrogenase from external oxygen. This will be a clue to understand the reason why the hydrogen production is so resistant to oxygen in this strain. (4) In this strain, sulfide can be used as electron donor for the hydrogen production. This result shows that waste water can be used for the hydrogen production system using this strain.

  3. Synthetic biology in plastids. (United States)

    Scharff, Lars B; Bock, Ralph


    Plastids (chloroplasts) harbor a small gene-dense genome that is amenable to genetic manipulation by transformation. During 1 billion years of evolution from the cyanobacterial endosymbiont to present-day chloroplasts, the plastid genome has undergone a dramatic size reduction, mainly as a result of gene losses and the large-scale transfer of genes to the nuclear genome. Thus the plastid genome can be regarded as a naturally evolved miniature genome, the gradual size reduction and compaction of which has provided a blueprint for the design of minimum genomes. Furthermore, because of the largely prokaryotic genome structure and gene expression machinery, the high transgene expression levels attainable in transgenic chloroplasts and the very low production costs in plant systems, the chloroplast lends itself to synthetic biology applications that are directed towards the efficient synthesis of green chemicals, biopharmaceuticals and other metabolites of commercial interest. This review describes recent progress with the engineering of plastid genomes with large constructs of foreign or synthetic DNA, and highlights the potential of the chloroplast as a model system in bottom-up and top-down synthetic biology approaches.

  4. Oscillations in Mathematical Biology

    CERN Document Server


    The papers in this volume are based on talks given at a one day conference held on the campus of Adelphi University in April 1982. The conference was organized with the title "Oscillations in Mathematical Biology;" however the speakers were allowed considerable latitutde in their choice of topics. In the event, the talks all concerned the dynamics of non-linear systems arising in biology so that the conference achieved a good measure of cohesion. Some of the speakers cho~e not to submit a manuscript for these proceedings, feeling that their material was too conjectural to be committed to print. Also the paper of Rinzel and Troy is a distillation of the two separate talks that the authors gave. Otherwise the material reproduces the conference proceedings. The conference was made possible by the generous support of the Office of the Dean of the College of Arts and Sciences at Adelphi. The bulk of the organization of the conference was carried out by Dr. Ronald Grisell whose energy was in large measure responsib...

  5. Neutron instrumentation for biology

    Energy Technology Data Exchange (ETDEWEB)

    Mason, S.A. [Institut Laue-Langevin, Grenoble (France)


    In the October 1994 round of proposals at the ILL, the external biology review sub- committee was asked to allocate neutron beam time to a wide range of experiments, on almost half the total number of scheduled neutron instruments: on 3 diffractometers, on 3 small angle scattering instruments, and on some 6 inelastic scattering spectrometers. In the 3.5 years since the temporary reactor shutdown, the ILL`s management structure has been optimized, budgets and staff have been trimmed, the ILL reactor has been re-built, and many of the instruments up-graded, many powerful (mainly Unix) workstations have been introduced, and the neighboring European Synchrotron Radiation Facility has established itself as the leading synchrotron radiation source and has started its official user program. The ILL reactor remains the world`s most intense dedicated neutron source. In this challenging context, it is of interest to review briefly the park of ILL instruments used to study the structure and energetics of small and large biological systems. A brief summary will be made of each class of experiments actually proposed in the latest ILL proposal round.

  6. Industrial systems biology. (United States)

    Otero, José Manuel; Nielsen, Jens


    The chemical industry is currently undergoing a dramatic change driven by demand for developing more sustainable processes for the production of fuels, chemicals, and materials. In biotechnological processes different microorganisms can be exploited, and the large diversity of metabolic reactions represents a rich repository for the design of chemical conversion processes that lead to efficient production of desirable products. However, often microorganisms that produce a desirable product, either naturally or because they have been engineered through insertion of heterologous pathways, have low yields and productivities, and in order to establish an economically viable process it is necessary to improve the performance of the microorganism. Here metabolic engineering is the enabling technology. Through metabolic engineering the metabolic landscape of the microorganism is engineered such that there is an efficient conversion of the raw material, typically glucose, to the product of interest. This process may involve both insertion of new enzymes activities, deletion of existing enzyme activities, but often also deregulation of existing regulatory structures operating in the cell. In order to rapidly identify the optimal metabolic engineering strategy the industry is to an increasing extent looking into the use of tools from systems biology. This involves both x-ome technologies such as transcriptome, proteome, metabolome, and fluxome analysis, and advanced mathematical modeling tools such as genome-scale metabolic modeling. Here we look into the history of these different techniques and review how they find application in industrial biotechnology, which will lead to what we here define as industrial systems biology.

  7. Mathematical modeling of biological processes

    CERN Document Server

    Friedman, Avner


    This book on mathematical modeling of biological processes includes a wide selection of biological topics that demonstrate the power of mathematics and computational codes in setting up biological processes with a rigorous and predictive framework. Topics include: enzyme dynamics, spread of disease, harvesting bacteria, competition among live species, neuronal oscillations, transport of neurofilaments in axon, cancer and cancer therapy, and granulomas. Complete with a description of the biological background and biological question that requires the use of mathematics, this book is developed for graduate students and advanced undergraduate students with only basic knowledge of ordinary differential equations and partial differential equations; background in biology is not required. Students will gain knowledge on how to program with MATLAB without previous programming experience and how to use codes in order to test biological hypothesis.

  8. Protein microarrays for systems biology

    Institute of Scientific and Technical Information of China (English)

    Lina Yang; Shujuan Guo; Yang Li; Shumin Zhou; Shengce Tao


    Systems biology holds the key for understanding biological systems on a system level. It eventually holds the key for the treatment and cure of complex diseases such as cancer,diabetes, obesity, mental disorders, and many others. The '-omics' technologies, such as genomics, transcriptomics,proteomics, and metabonomics, are among the major driving forces of systems biology. Featured as highthroughput, miniaturized, and capable of parallel analysis,protein microarrays have already become an important technology platform for systems biology, In this review, we will focus on the system level or global analysis of biological systems using protein microarrays. Four major types of protein microarrays will be discussed: proteome microarrays, antibody microarrays, reverse-phase protein arrays,and lectin microarrays. We will also discuss the challenges and future directions of protein microarray technologies and their applications for systems biology. We strongly believe that protein microarrays will soon become an indispensable and invaluable tool for systems biology.

  9. Microgravity Fluids for Biology, Workshop (United States)

    Griffin, DeVon; Kohl, Fred; Massa, Gioia D.; Motil, Brian; Parsons-Wingerter, Patricia; Quincy, Charles; Sato, Kevin; Singh, Bhim; Smith, Jeffrey D.; Wheeler, Raymond M.


    Microgravity Fluids for Biology represents an intersection of biology and fluid physics that present exciting research challenges to the Space Life and Physical Sciences Division. Solving and managing the transport processes and fluid mechanics in physiological and biological systems and processes are essential for future space exploration and colonization of space by humans. Adequate understanding of the underlying fluid physics and transport mechanisms will provide new, necessary insights and technologies for analyzing and designing biological systems critical to NASAs mission. To enable this mission, the fluid physics discipline needs to work to enhance the understanding of the influence of gravity on the scales and types of fluids (i.e., non-Newtonian) important to biology and life sciences. In turn, biomimetic, bio-inspired and synthetic biology applications based on physiology and biology can enrich the fluid mechanics and transport phenomena capabilities of the microgravity fluid physics community.

  10. Synthetic biology: ethical ramifications 2009. (United States)

    Rabinow, Paul; Bennett, Gaymon


    During 2007 and 2008 synthetic biology moved from the manifesto stage to research programs. As of 2009, synthetic biology is ramifying; to ramify means to produce differentiated trajectories from previous determinations. From its inception, most of the players in synthetic biology agreed on the need for (a) rationalized design and construction of new biological parts, devices, and systems as well as (b) the re-design of natural biological systems for specified purposes, and that (c) the versatility of designed biological systems makes them suitable to address such challenges as renewable energy, the production of inexpensive drugs, and environmental remediation, as well as providing a catalyst for further growth of biotechnology. What is understood by these goals, however, is diverse. Those assorted understandings are currently contributing to different ramifications of synthetic biology. The Berkeley Human Practices Lab, led by Paul Rabinow, is currently devoting its efforts to documenting and analyzing these ramifications as they emerge.

  11. Bridging the gap between systems biology and synthetic biology. (United States)

    Liu, Di; Hoynes-O'Connor, Allison; Zhang, Fuzhong


    Systems biology is an inter-disciplinary science that studies the complex interactions and the collective behavior of a cell or an organism. Synthetic biology, as a technological subject, combines biological science and engineering, allowing the design and manipulation of a system for certain applications. Both systems and synthetic biology have played important roles in the recent development of microbial platforms for energy, materials, and environmental applications. More importantly, systems biology provides the knowledge necessary for the development of synthetic biology tools, which in turn facilitates the manipulation and understanding of complex biological systems. Thus, the combination of systems and synthetic biology has huge potential for studying and engineering microbes, especially to perform advanced tasks, such as producing biofuels. Although there have been very few studies in integrating systems and synthetic biology, existing examples have demonstrated great power in extending microbiological capabilities. This review focuses on recent efforts in microbiological genomics, transcriptomics, proteomics, and metabolomics, aiming to fill the gap between systems and synthetic biology.

  12. Molecular biology of potyviruses. (United States)

    Revers, Frédéric; García, Juan Antonio


    Potyvirus is the largest genus of plant viruses causing significant losses in a wide range of crops. Potyviruses are aphid transmitted in a nonpersistent manner and some of them are also seed transmitted. As important pathogens, potyviruses are much more studied than other plant viruses belonging to other genera and their study covers many aspects of plant virology, such as functional characterization of viral proteins, molecular interaction with hosts and vectors, structure, taxonomy, evolution, epidemiology, and diagnosis. Biotechnological applications of potyviruses are also being explored. During this last decade, substantial advances have been made in the understanding of the molecular biology of these viruses and the functions of their various proteins. After a general presentation on the family Potyviridae and the potyviral proteins, we present an update of the knowledge on potyvirus multiplication, movement, and transmission and on potyvirus/plant compatible interactions including pathogenicity and symptom determinants. We end the review providing information on biotechnological applications of potyviruses.

  13. Networks in Cell Biology (United States)

    Buchanan, Mark; Caldarelli, Guido; De Los Rios, Paolo; Rao, Francesco; Vendruscolo, Michele


    Introduction; 1. Network views of the cell Paolo De Los Rios and Michele Vendruscolo; 2. Transcriptional regulatory networks Sarath Chandra Janga and M. Madan Babu; 3. Transcription factors and gene regulatory networks Matteo Brilli, Elissa Calistri and Pietro Lió; 4. Experimental methods for protein interaction identification Peter Uetz, Björn Titz, Seesandra V. Rajagopala and Gerard Cagney; 5. Modeling protein interaction networks Francesco Rao; 6. Dynamics and evolution of metabolic networks Daniel Segré; 7. Hierarchical modularity in biological networks: the case of metabolic networks Erzsébet Ravasz Regan; 8. Signalling networks Gian Paolo Rossini; Appendix 1. Complex networks: from local to global properties D. Garlaschelli and G. Caldarelli; Appendix 2. Modelling the local structure of networks D. Garlaschelli and G. Caldarelli; Appendix 3. Higher-order topological properties S. Ahnert, T. Fink and G. Caldarelli; Appendix 4. Elementary mathematical concepts A. Gabrielli and G. Caldarelli; References.

  14. The biology of strigolactones

    KAUST Repository

    Ruyter-Spira, Carolien P.


    The strigolactones are rhizosphere signaling molecules as well as a new class of plant hormones with a still increasing number of biological functions being uncovered. Here, we review a recent major breakthrough in our understanding of strigolactone biosynthesis, which has revealed the unexpected simplicity of the originally postulated complex pathway. Moreover, the discovery and localization of a strigolactone exporter sheds new light on putative strigolactone fluxes to the rhizosphere as well as within the plant. The combination of these data with information on the expression and regulation of strigolactone biosynthetic and downstream signaling genes provides new insights into how strigolactones control the many different aspects of plant development and how their rhizosphere signaling role may have evolved. © 2012 Elsevier Ltd.

  15. Plant Vascular Biology 2010

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Biao


    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  16. A Biologically Inspired Classifier

    CERN Document Server

    Bagnoli, Franco


    We present a method for measuring the distance among records based on the correlations of data stored in the corresponding database entries. The original method (F. Bagnoli, A. Berrones and F. Franci. Physica A 332 (2004) 509-518) was formulated in the context of opinion formation. The opinions expressed over a set of topic originate a ``knowledge network'' among individuals, where two individuals are nearer the more similar their expressed opinions are. Assuming that individuals' opinions are stored in a database, the authors show that it is possible to anticipate an opinion using the correlations in the database. This corresponds to approximating the overlap between the tastes of two individuals with the correlations of their expressed opinions. In this paper we extend this model to nonlinear matching functions, inspired by biological problems such as microarray (probe-sample pairing). We investigate numerically the error between the correlation and the overlap matrix for eight sequences of reference with r...

  17. Biology of Sexual Dysfunction

    Directory of Open Access Journals (Sweden)

    Anil Kumar Mysore Nagaraj


    Full Text Available Sexual activity is a multifaceted activity, involving complex interactions between the nervous system, the endocrine system, the vascular system and a variety of structures that are instrumental in sexual excitement, intercourse and satisfaction. Sexual function has three components i.e., desire, arousal and orgasm. Many sexual dysfunctions can be categorized according to the phase of sexual response that is affected. In actual clinical practice however, sexual desire, arousal and orgasmic difficulties more often than not coexist, suggesting an integration of phases. Sexual dysfunction can result from a wide variety of psychological and physiological causes including derangements in the levels of sex hormones and neurotrensmitters. This review deals with the biology of different phases of sexual function as well as implications of hormones and neurotransmitters in sexual dysfunction

  18. Evolutionary biology of cancer. (United States)

    Crespi, Bernard; Summers, Kyle


    Cancer is driven by the somatic evolution of cell lineages that have escaped controls on replication and by the population-level evolution of genes that influence cancer risk. We describe here how recent evolutionary ecological studies have elucidated the roles of predation by the immune system and competition among normal and cancerous cells in the somatic evolution of cancer. Recent analyses of the evolution of cancer at the population level show how rapid changes in human environments have augmented cancer risk, how strong selection has frequently led to increased cancer risk as a byproduct, and how anticancer selection has led to tumor-suppression systems, tissue designs that slow somatic evolution, constraints on morphological evolution and even senescence itself. We discuss how applications of the tools of ecology and evolutionary biology are poised to revolutionize our understanding and treatment of this disease.

  19. Biology of Schwann cells. (United States)

    Kidd, Grahame J; Ohno, Nobuhiko; Trapp, Bruce D


    The fundamental roles of Schwann cells during peripheral nerve formation and regeneration have been recognized for more than 100 years, but the cellular and molecular mechanisms that integrate Schwann cell and axonal functions continue to be elucidated. Derived from the embryonic neural crest, Schwann cells differentiate into myelinating cells or bundle multiple unmyelinated axons into Remak fibers. Axons dictate which differentiation path Schwann cells follow, and recent studies have established that axonal neuregulin1 signaling via ErbB2/B3 receptors on Schwann cells is essential for Schwann cell myelination. Extracellular matrix production and interactions mediated by specific integrin and dystroglycan complexes are also critical requisites for Schwann cell-axon interactions. Myelination entails expansion and specialization of the Schwann cell plasma membrane over millimeter distances. Many of the myelin-specific proteins have been identified, and transgenic manipulation of myelin genes have provided novel insights into myelin protein function, including maintenance of axonal integrity and survival. Cellular events that facilitate myelination, including microtubule-based protein and mRNA targeting, and actin based locomotion, have also begun to be understood. Arguably, the most remarkable facet of Schwann cell biology, however, is their vigorous response to axonal damage. Degradation of myelin, dedifferentiation, division, production of axonotrophic factors, and remyelination all underpin the substantial regenerative capacity of the Schwann cells and peripheral nerves. Many of these properties are not shared by CNS fibers, which are myelinated by oligodendrocytes. Dissecting the molecular mechanisms responsible for the complex biology of Schwann cells continues to have practical benefits in identifying novel therapeutic targets not only for Schwann cell-specific diseases but other disorders in which axons degenerate.

  20. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun


    This dissertation considers the ontology of stem cells as a future-oriented life form characterized by its potentiality in relation to the anticipatory mode of living in contemporary Korea. The biological notion that stem cells have the potential for differentiation and the capacity for self-rene...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  1. Systems biology: a biologist's viewpoint. (United States)

    Bose, Biplab


    The debate over reductionism and antireductionism in biology is very old. Even the systems approach in biology is more than five decades old. However, mainstream biology, particularly experimental biology, has broadly sidestepped those debates and ideas. Post-genome data explosion and development of high-throughput techniques led to resurfacing of those ideas and debates as a new incarnation called Systems Biology. Though experimental biologists have co-opted systems biology and hailed it as a paradigm shift, it is practiced in different shades and understood with divergent meanings. Biology has certain questions linked with organization of multiple components and processes. Often such questions involve multilevel systems. Here in this essay we argue that systems theory provides required framework and abstractions to explore those questions. We argue that systems biology should follow the logical and mathematical approach of systems theory and transmogrification of systems biology to mere collection of higher dimensional data must be avoided. Therefore, the questions that we ask and the priority of those questions should also change. Systems biology should focus on system-level properties and investigate complexity without shying away from it.

  2. Biology of biological meshes used in hernia repair. (United States)

    Novitsky, Yuri W


    Successful repair of most hernias requires the use of a prosthetic implant for reinforcement of the defect. Because of the need for prosthetic implants to resist infections as well to support repairs in contaminated or potentially contaminated fields, biological meshes have been developed to take the place of nondegradable synthetic meshes in cases where mesh infection is of high concern. The ideal is a biological matrix that resists infection while providing durable reinforcement of a hernia repair. This article reviews the validity of assumptions that support the purported notion of the biological behavior of biological meshes.

  3. Microfluidic Technologies for Synthetic Biology

    Directory of Open Access Journals (Sweden)

    Sung Kuk Lee


    Full Text Available Microfluidic technologies have shown powerful abilities for reducing cost, time, and labor, and at the same time, for increasing accuracy, throughput, and performance in the analysis of biological and biochemical samples compared with the conventional, macroscale instruments. Synthetic biology is an emerging field of biology and has drawn much attraction due to its potential to create novel, functional biological parts and systems for special purposes. Since it is believed that the development of synthetic biology can be accelerated through the use of microfluidic technology, in this review work we focus our discussion on the latest microfluidic technologies that can provide unprecedented means in synthetic biology for dynamic profiling of gene expression/regulation with high resolution, highly sensitive on-chip and off-chip detection of metabolites, and whole-cell analysis.

  4. Quantum Effects in Biological Systems

    CERN Document Server


    Since the last decade the study of quantum mechanical phenomena in biological systems has become a vibrant field of research. Initially sparked by evidence of quantum effects in energy transport that is instrumental for photosynthesis, quantum biology asks the question of how methods and models from quantum theory can help us to understand fundamental mechanisms in living organisms. This approach entails a paradigm change challenging the related disciplines: The successful framework of quantum theory is taken out of its low-temperature, microscopic regimes and applied to hot and dense macroscopic environments, thereby extending the toolbox of biology and biochemistry at the same time. The Quantum Effects in Biological Systems conference is a platform for researchers from biology, chemistry and physics to present and discuss the latest developments in the field of quantum biology. After meetings in Lisbon (2009), Harvard (2010), Ulm (2011), Berkeley (2012), Vienna (2013), Singapore (2014) and Florence (2015),...

  5. Values, Advocay and Conservation Biology



    In this essay, I examine the controversy concerning the advocacy of ethical values in conservation biology. First, I argue, as others have, that conservation biology is a science laden with values both ethical and non-ethical. Second, after clarifying the notion of advocacy at work, I contend that conservation biologists should advocate the preservation of biological diversity. Third, I explore what ethical grounds should be used for advocating the preservation of ecological systems by conser...

  6. Relations between intuitive biological thinking and biological misconceptions in biology majors and nonmajors. (United States)

    Coley, John D; Tanner, Kimberly


    Research and theory development in cognitive psychology and science education research remain largely isolated. Biology education researchers have documented persistent scientifically inaccurate ideas, often termed misconceptions, among biology students across biological domains. In parallel, cognitive and developmental psychologists have described intuitive conceptual systems--teleological, essentialist, and anthropocentric thinking--that humans use to reason about biology. We hypothesize that seemingly unrelated biological misconceptions may have common origins in these intuitive ways of knowing, termed cognitive construals. We presented 137 undergraduate biology majors and nonmajors with six biological misconceptions. They indicated their agreement with each statement, and explained their rationale for their response. Results indicate frequent agreement with misconceptions, and frequent use of construal-based reasoning among both biology majors and nonmajors in their written explanations. Moreover, results also show associations between specific construals and the misconceptions hypothesized to arise from those construals. Strikingly, such associations were stronger among biology majors than nonmajors. These results demonstrate important linkages between intuitive ways of thinking and misconceptions in discipline-based reasoning, and raise questions about the origins, persistence, and generality of relations between intuitive reasoning and biological misconceptions.

  7. NASA space biology accomplishments, 1982 (United States)

    Halstead, T. W.; Pleasant, L. G.


    Summaries of NASA's Space Biology Program projects are provided. The goals, objectives, accomplishments, and future plans of each project are described in this publication as individual technical summaries.

  8. Engineering Nanoscale Biological Molecular Motors


    Korosec, Chapin; Forde, Nancy R.


    Understanding the operation of biological molecular motors, nanoscale machines that transduce electrochemical energy into mechanical work, is enhanced by bottom-up strategies to synthesize novel motors.

  9. Telemetry System of Biological Parameters

    Directory of Open Access Journals (Sweden)

    Jan Spisak


    Full Text Available The mobile telemetry system of biological parameters serves for reading and wireless data transfer of measured values of selected biological parameters to an outlying computer. It concerns basically long time monitoring of vital function of car pilot.The goal of this projects is to propose mobile telemetry system for reading, wireless transfer and processing of biological parameters of car pilot during physical and psychical stress. It has to be made with respect to minimal consumption, weight and maximal device mobility. This system has to eliminate signal noise, which is created by biological artifacts and disturbances during the data transfer.

  10. Biological and medical sensor technologies

    CERN Document Server

    Iniewski, Krzysztof


    Biological and Medical Sensor Technologies presents contributions from top experts who explore the development and implementation of sensors for various applications used in medicine and biology. Edited by a pioneer in the area of advanced semiconductor materials, the book is divided into two sections. The first part covers sensors for biological applications. Topics include: Advanced sensing and communication in the biological world DNA-derivative architectures for long-wavelength bio-sensing Label-free silicon photonics Quartz crystal microbalance-based biosensors Lab-on-chip technologies fo

  11. American Institute of Biological Sciences (United States)

    ... organizations advancing biology through membership in AIBS News Trump's FY 2018 Budget Request Would Slash Most Science Programs President Trump's first budget request seeks historically deep budget cuts ...

  12. Synthetic biology for therapeutic applications. (United States)

    Abil, Zhanar; Xiong, Xiong; Zhao, Huimin


    Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug discovery and production, as well as vaccine development and treatment of infectious diseases, cancer, and metabolic disorders.

  13. Computer algebra in systems biology

    CERN Document Server

    Laubenbacher, Reinhard


    Systems biology focuses on the study of entire biological systems rather than on their individual components. With the emergence of high-throughput data generation technologies for molecular biology and the development of advanced mathematical modeling techniques, this field promises to provide important new insights. At the same time, with the availability of increasingly powerful computers, computer algebra has developed into a useful tool for many applications. This article illustrates the use of computer algebra in systems biology by way of a well-known gene regulatory network, the Lac Operon in the bacterium E. coli.

  14. Bioinspired materials: Boosting plant biology (United States)

    Scholes, Gregory D.; Sargent, Edward H.


    Chloroplasts with extended photosynthetic activity beyond the visible absorption spectrum, and living leaves that perform non-biological functions, are made possible by localizing nanoparticles within plant organelles.

  15. Rotating Biological Contractors (RBC's). Instructor's Guide. Biological Treatment Process Control. (United States)

    Zickefoose, Charles S.

    This two-lesson unit on rotating biological contactors (RBC's) is designed to be used with students who have had some experience in wastewater treatment and a basic understanding of biological treatment. The first lesson provides information on the concepts and components of RBC treatment systems. The second lesson focuses on design operation and…

  16. Exploring Visuomotor Priming Following Biological and Non-Biological Stimuli (United States)

    Gowen, E.; Bradshaw, C.; Galpin, A.; Lawrence, A.; Poliakoff, E.


    Observation of human actions influences the observer's own motor system, termed visuomotor priming, and is believed to be caused by automatic activation of mirror neurons. Evidence suggests that priming effects are larger for biological (human) as opposed to non-biological (object) stimuli and enhanced when viewing stimuli in mirror compared to…

  17. Quantitative biology: where modern biology meets physical sciences. (United States)

    Shekhar, Shashank; Zhu, Lian; Mazutis, Linas; Sgro, Allyson E; Fai, Thomas G; Podolski, Marija


    Quantitative methods and approaches have been playing an increasingly important role in cell biology in recent years. They involve making accurate measurements to test a predefined hypothesis in order to compare experimental data with predictions generated by theoretical models, an approach that has benefited physicists for decades. Building quantitative models in experimental biology not only has led to discoveries of counterintuitive phenomena but has also opened up novel research directions. To make the biological sciences more quantitative, we believe a two-pronged approach needs to be taken. First, graduate training needs to be revamped to ensure biology students are adequately trained in physical and mathematical sciences and vice versa. Second, students of both the biological and the physical sciences need to be provided adequate opportunities for hands-on engagement with the methods and approaches necessary to be able to work at the intersection of the biological and physical sciences. We present the annual Physiology Course organized at the Marine Biological Laboratory (Woods Hole, MA) as a case study for a hands-on training program that gives young scientists the opportunity not only to acquire the tools of quantitative biology but also to develop the necessary thought processes that will enable them to bridge the gap between these disciplines.

  18. "Protected biological control"- Biological pest management in the greenhouse industry

    NARCIS (Netherlands)

    Pilkington, L.J.; Messelink, G.J.; Lenteren, van J.C.; Mottee, Le K.


    This paper briefly describes the foundations and characteristics of biological control in protected cropping and what drivers are behind adoption of this management system within this industry. Examining a brief history of biological control in greenhouses and what makes it a successful management s

  19. Crystallogenesis of biological macromolecules. Biological, microgravity and other physicochemical aspects

    NARCIS (Netherlands)

    Giege, R; Drenth, J; Ducruix, A; McPherson, A; Saenger, W


    After an historical introduction and justification of the importance of proteins (as well as other macromolecules or macromolecular assemblies of biological origin) in modern biology but also in physics, this review presents the state of the field of macromolecular crystallogenesis. The basic questi

  20. [Hemodialysis with biological object]. (United States)

    Eventov, V L; Maksimenko, V A; Zhidkov, I L; Andrianova, M Iu


    The essence of the method of biodialysis (hemodialysis with biological object) developed and suggested by the authors for clinical use consists in that the healthy organism exerts, through a system of mass transfer, a therapeutic action on the sick organism. Blood from the affected and healthy organisms is perfused through individual mass exchangers (dialyzers, hemodiafilters and hemofilters), which are hydraulically connected by a circulating transport medium. Metabolites that accumulate in blood of the affected organism diffuse into the transport medium and, from there, into blood of the healthy organism, which metabolizes them. The reverse process occurs simultaneously: substances, whose concentration in blood of the sick organism is less versus the healthy organism, diffuse from blood of the healthy organism to blood of patient. The method suggested by us can be used in clinical practice for normalizing a variety of parameters in patients with hepatic and renal insufficiency. Besides, a number of substances can be transferred from the healthy donor to patient in the process of biodialysis, which opens promising potentialities for the treatment of many diseases.

  1. Consciousness and biological evolution. (United States)

    Lindahl, B I


    It has been suggested that if the preservation and development of consciousness in the biological evolution is a result of natural selection, it is plausible that consciousness not only has been influenced by neural processes, but has had a survival value itself; and it could only have had this, if it had also been efficacious. This argument for mind-brain interaction is examined, both as the argument has been developed by William James and Karl Popper and as it has been discussed by C.D. Broad. The problem of identifying mental phenomena with certain neural phenomena is also addressed. The main conclusion of the analysis is that an explanation of the evolution of consciousness in Darwinian terms of natural selection does not rule out that consciousness may have evolved as a mere causally inert effect of the evolution of the nervous system, or that mental phenomena are identical with certain neural phenomena. However, the interactionistic theory still seems, more plausible and more fruitful for other reasons brought up in the discussion.

  2. Flotation of Biological Materials

    Directory of Open Access Journals (Sweden)

    George Z. Kyzas


    Full Text Available Flotation constitutes a gravity separation process, which originated from the minerals processing field. However, it has, nowadays, found several other applications, as for example in the wastewater treatment field. Concerning the necessary bubble generation method, typically dispersed-air or dissolved-air flotation was mainly used. Various types of biological materials were tested and floated efficiently, such as bacteria, fungi, yeasts, activated sludge, grape stalks, etc. Innovative processes have been studied in our Laboratory, particularly for metal ions removal, involving the initial abstraction of heavy metal ions onto a sorbent (including a biosorbent: in the first, the application of a flotation stage followed for the efficient downstream separation of metal-laden particles. The ability of microorganisms to remove metal ions from dilute aqueous solutions (as most wastewaters are is a well-known property. The second separation process, also applied effectively, was a new hybrid cell of microfiltration combined with flotation. Sustainability in this field and its significance for the chemical and process industry is commented.

  3. [Biology molecular of glioblastomas]. (United States)

    Franco-Hernández, C; Martínez-Glez, V; Rey, J A


    Glioblastomas, the most frequent and malignant human brain tumors, may develop de novo (primary glioblastoma) or by progression from low-grade or anapalsic astrocytoma (secondary glioblastoma). The molecular alteration most frequent in these tumor-like types is the loss of heterozygosity on chromosome 10, in which several genes have been identified as tumors suppressor. The TP53/MDM2/P14arf and CDK4/RB1/ P16ink4 genetic pathways involved in cycle control are deregulated in the majority of gliomas as well as genes that promote the cellular division, EGFR. Finally the increase of growth and angiogenics factors is also involved in the development of glioblastomas. One of the objectives of molecular biology in tumors of glial ancestry is to try to find the genetic alterations that allow to approach better the classification of glioblastomas, its evolution prediction and treatment. The new pathmolecular classification of gliomas should improve the old one, especially being concerned about the oncogenesis and heterogeneity of these tumors. It is desirable that this classification had clinical applicability and integrates new molecular findings with some known histological features with pronostic value. In this paper we review the most frequent molecular mechanisms involved in the patogenesis of glioblastomas.

  4. Mesangial cell biology

    Energy Technology Data Exchange (ETDEWEB)

    Abboud, Hanna E., E-mail:


    Mesangial cells originate from the metanephric mesenchyme and maintain structural integrity of the glomerular microvascular bed and mesangial matrix homeostasis. In response to metabolic, immunologic or hemodynamic injury, these cells undergo apoptosis or acquire an activated phenotype and undergo hypertrophy, proliferation with excessive production of matrix proteins, growth factors, chemokines and cytokines. These soluble factors exert autocrine and paracrine effects on the cells or on other glomerular cells, respectively. MCs are primary targets of immune-mediated glomerular diseases such as IGA nephropathy or metabolic diseases such as diabetes. MCs may also respond to injury that primarily involves podocytes and endothelial cells or to structural and genetic abnormalities of the glomerular basement membrane. Signal transduction and oxidant stress pathways are activated in MCs and likely represent integrated input from multiple mediators. Such responses are convenient targets for therapeutic intervention. Studies in cultured MCs should be supplemented with in vivo studies as well as examination of freshly isolated cells from normal and diseases glomeruli. In addition to ex vivo morphologic studies in kidney cortex, cells should be studied in their natural environment, isolated glomeruli or even tissue slices. Identification of a specific marker of MCs should help genetic manipulation as well as selective therapeutic targeting of these cells. Identification of biological responses of MCs that are not mediated by the renin–angiotensin system should help development of novel and effective therapeutic strategies to treat diseases characterized by MC pathology.

  5. Biological rhythms and preeclampsia

    Directory of Open Access Journals (Sweden)

    Agnès eDitisheim


    Full Text Available The impact of impaired circadian rhythm on health has been widely studied in shift workers and trans-meridian travelers. A part from its correlation with sleep and mood disorders, biological rhythm impairment is a recognized risk factor for cardiovascular diseases and breast cancer.Preeclampsia is a major public health issue, associated with a significant maternal and fetal morbidity and mortality worldwide. While the risks factors for this condition such as obesity, diabetes, pre-existing hypertension have been identified, the underlying mechanism of this multi-factorial disease is yet not fully understood.The disruption of the light/dark cycle in pregnancy has been associated with adverse outcomes. Slightly increased risk for small for gestational age babies, low birth weight babies and preterm deliveries has been reported in shift working women. Whether altered circadian cycle represents a risk factor for preeclampsia or preeclampsia is itself linked with an abnormal circadian cycle is less clear. There are only few reports available, showing conflicting results. In this review, we will discuss recent observations concerning circadian pattern of blood pressure in normotensive and hypertensive pregnancies. We explore the hypothesis that circadian misalignments may represent a risk factor for preeclampsia. Unraveling potential link between circadian clock gene and preeclampsia could offer a novel approach to our understanding of this multi-system disease specific to pregnancy.

  6. Biological control of ticks (United States)

    Samish, M.; Ginsberg, H.; Glazer, I.; Bowman, A.S.; Nuttall, P.


    Ticks have numerous natural enemies, but only a few species have been evaluated as tick biocontrol agents (BCAs). Some laboratory results suggest that several bacteria are pathogenic to ticks, but their mode of action and their potential value as biocontrol agents remain to be determined. The most promising entomopathogenic fungi appear to be Metarhizium anisopliae and Beauveria bassiana, strains of which are already commercially available for the control of some pests. Development of effective formulations is critical for tick management. Entomopathogenic nematodes that are pathogenic to ticks can potentially control ticks, but improved formulations and selection of novel nematode strains are needed. Parasitoid wasps of the genus Ixodiphagus do not typically control ticks under natural conditions, but inundative releases show potential value. Most predators of ticks are generalists, with a limited potential for tick management (one possible exception is oxpeckers in Africa). Biological control is likely to play a substantial role in future IPM programmes for ticks because of the diversity of taxa that show high potential as tick BCAs. Considerable research is required to select appropriate strains, develop them as BCAs, establish their effectiveness, and devise production strategies to bring them to practical use.

  7. Aristotle's biopolitics: a defense of biological teleology against biological nihilism. (United States)

    Arnhart, L


    Modern Darwinian biology seems to promote nihilism, for it seems to teach that there is no rationally discoverable standard in nature for giving meaning to life. The purpose of this article is to argue for a revival of Aristotle's biological teleology as a reasonable alternative to biological nihilism. The article begins with Edward Wilson's vain struggle against nihilism. Then it is argued that a teleological understanding of nature is assumed in the practice of medicine, as illustrated by one case from Oliver Sacks' neurological practice. The article then considers the importance of biological teleology for Aristotle's moral and political philosophy, and attention is given to some points of agreement and disagreement with contemporary sociobiologists. The main part of the article is then devoted to a defense of Aristotle's biology against the five objections that might be made by a Darwinian biologist. Finally, the article illustrates the practical implications of this issue for bioethics by considering the recent work of Engelhardt.

  8. Introduction to Biology, Tropical Edition. (United States)

    Mackean, D. G.

    This pupil's reference book is intended to provide biological information, using plants and animals which are suitable for study over a wide range of tropical countries. Its topics are taken mostly from the biology syllabi for the British General Certification of Education at the Ordinary Level and are written principally for pupils in the last…

  9. Biology and Water Pollution Control. (United States)

    Warren, Charles E.

    Within this text, the reader is attuned to the role biology can and should play in combating the alarming increase in water pollution. Both the urgency of the problem and the biological techniques that are being developed to cope with the water pollution crisis are scrutinized; what is and is not known about the problem is explained; past,…

  10. Space Biology: Patterns of Life (United States)

    Salisbury, Frank B.


    Present knowledge about Mars is compared with past beliefs about the planet. Biological experiments that indicate life may exist on Mars are interpreted. Life patterns or biological features that might be postulated for extraterrestrial life are presented at the molecular, cellular, organism, and ecosystem levels. (DS)

  11. Marine Biology and Human Affairs (United States)

    Russell, F. S.


    Marine biology has become an important area for study throughout the world. The author of this article discusses some of the important discoveries and fields of research in marine biology that are useful for mankind. Topics include food from the sea, fish farming, pesticides, pollution, and conservation. (MA)

  12. Querying Large Biological Network Datasets (United States)

    Gulsoy, Gunhan


    New experimental methods has resulted in increasing amount of genetic interaction data to be generated every day. Biological networks are used to store genetic interaction data gathered. Increasing amount of data available requires fast large scale analysis methods. Therefore, we address the problem of querying large biological network datasets.…

  13. Validation of systems biology models

    NARCIS (Netherlands)

    Hasdemir, D.


    The paradigm shift from qualitative to quantitative analysis of biological systems brought a substantial number of modeling approaches to the stage of molecular biology research. These include but certainly are not limited to nonlinear kinetic models, static network models and models obtained by the

  14. Structural Biology Guides Antibiotic Discovery (United States)

    Polyak, Steven


    Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…

  15. Biological Effectiveness of Antiproton Annihilation

    DEFF Research Database (Denmark)

    Maggiore, C.; Agazaryan, N.; Bassler, N.;


    from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The background, description, and status...

  16. Static Analysis for Systems Biology

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis; Rosa, D. Schuch da


    This paper shows how static analysis techniques can help understanding biological systems. Based on a simple example we illustrate the outcome of performing three different analyses extracting information of increasing precision. We conclude by reporting on the potential impact and exploitation o...... of these techniques in systems biology....

  17. Interfacing DNA nanodevices with biology

    DEFF Research Database (Denmark)

    Vinther, Mathias; Kjems, Jørgen


    in biology and biomedicine acting as a molecular ‘nanorobot’ or smart drug interacting with the cellular machinery. In this review, we will explore and examine the perspective of DNA nanotechnology for such use. We summarize which requirements DNA nanostructures must fulfil to function in cellular...... environments and inside living organisms. In addition, we highlight recent advances in interfacing DNA nanostructures with biology....

  18. From Biology to Quality (BQ)

    DEFF Research Database (Denmark)

    Nielsen, Michael Engelbrecht; Ingerslev, Hans-Christian


    “Quality is never an accident; it is always the result of high intention, sincere effort, intelligent direction and skilful execution; it represents the wise choice of many alternatives.” (William A. Foster) The quality of fish meat is dependent upon a wide range of biological and non-biological ...

  19. The Ethics of Synthetic Biology

    DEFF Research Database (Denmark)

    Christiansen, Andreas

    The dissertation analyses and discusses a number of ethical issues that have been raised in connection with the development of synthetic biology. Synthetic biology is a set of new techniques for DNA-level design and construction of living beings with useful properties. The dissertation especially...

  20. Biological clocks: riding the tides. (United States)

    de la Iglesia, Horacio O; Johnson, Carl Hirschie


    Animals with habitats in the intertidal zone often display biological rhythms that coordinate with both the tidal and the daily environmental cycles. Two recent studies show that the molecular components of the biological clocks mediating tidal rhythms are likely different from the phylogenetically conserved components that mediate circadian (daily) rhythms.

  1. BIological Psychology, Exercise, and Stress. (United States)

    Dishman, Rod K.


    Reviews theory and methods used by the field of biological psychology to study stress that have potential for understanding how behavioral and biological adaptations to the stress of exercise are integrated. The overview focuses on anxiety, depression, and physiological responsiveness to nonexercise stressors from the perspective of biological…

  2. Virtual Environments in Biology Teaching (United States)

    Mikropoulos, Tassos A.; Katsikis, Apostolos; Nikolou, Eugenia; Tsakalis, Panayiotis


    This article reports on the design, development and evaluation of an educational virtual environment for biology teaching. In particular it proposes a highly interactive three-dimensional synthetic environment involving certain learning tasks for the support of teaching plant cell biology and the process of photosynthesis. The environment has been…

  3. An Exercise in Biological Control. (United States)

    Lennox, John; Duke, Michael


    Discusses the history of the use of pesticides and biological control. Introduces the concept of biological control as illustrated in the use of the entomopathogenic bacterium Bacillus thuringiensis and highlights laboratory demonstrations of Koch's postulates. Includes an exercise that offers the student and teacher several integrated learning…

  4. Vitalism in Naive Biological Thinking. (United States)

    Morris, Suzanne C.; Taplin, John E.; Gelman, Susan A.


    Three experiments investigated use of vitalistic explanations for biological phenomena by 5- and 10-year-olds and by adults. Results replicated the original Japanese finding of vitalistic thinking among English-speaking 5-year-olds, identified the more active component of vitalism as a belief in the transfer of energy during biological processes,…

  5. Synthetic biology and genetic causation. (United States)

    Oftedal, Gry; Parkkinen, Veli-Pekka


    Synthetic biology research is often described in terms of programming cells through the introduction of synthetic genes. Genetic material is seemingly attributed with a high level of causal responsibility. We discuss genetic causation in synthetic biology and distinguish three gene concepts differing in their assumptions of genetic control. We argue that synthetic biology generally employs a difference-making approach to establishing genetic causes, and that this approach does not commit to a specific notion of genetic program or genetic control. Still, we suggest that a strong program concept of genetic material can be used as a successful heuristic in certain areas of synthetic biology. Its application requires control of causal context, and may stand in need of a modular decomposition of the target system. We relate different modularity concepts to the discussion of genetic causation and point to possible advantages of and important limitations to seeking modularity in synthetic biology systems.

  6. Combining supramolecular chemistry with biology. (United States)

    Uhlenheuer, Dana A; Petkau, Katja; Brunsveld, Luc


    Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins and lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine these synthetic supramolecular elements with biomolecules for the study of biological phenomena. This tutorial review focuses on the possibilities of the marriage of synthetic supramolecular architectures and biological systems. It highlights that synthetic supramolecular elements are for example ideal platforms for the recognition and modulation of proteins and cells. The unique features of synthetic supramolecular systems with control over size, shape, valency, and interaction strength allow the generation of structures fitting the demands to approach the biological problems at hand. Supramolecular chemistry has come full circle, studying the biology and its molecules which initially inspired its conception.

  7. Engineering life through Synthetic Biology. (United States)

    Chopra, Paras; Kamma, Akhil


    Synthetic Biology is a field involving synthesis of novel biological systems which are not generally found in nature. It has brought a new paradigm in science as it has enabled scientists to create life from the scratch, hence helping better understand the principles of biology. The viability of living organisms that use unnatural molecules is also being explored. Unconventional projects such as DNA playing tic-tac-toe, bacterial photographic film, etc. are taking biology to its extremes. The field holds a promise for mass production of cheap drugs and programming bacteria to seek-and-destroy tumors in the body. However, the complexity of biological systems make the field a challenging one. In addition to this, there are other major technical and ethical challenges which need to be addressed before the field realizes its true potential.

  8. Grand challenges for biological engineering. (United States)

    Yoon, Jeong-Yeol; Riley, Mark R


    Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE) released a document "Grand Challenges in Engineering," covering broad realms of human concern from sustainability, health, vulnerability and the joy of living. Biological engineers, having tools and techniques at the interface between living and non-living entities, will play a prominent role in forging a better future. The 2010 Institute of Biological Engineering (IBE) conference in Cambridge, MA, USA will address, in part, the roles of biological engineering in solving the challenges presented by the NAE. This letter presents a brief outline of how biological engineers are working to solve these large scale and integrated problems of our society.

  9. Grand challenges for biological engineering

    Directory of Open Access Journals (Sweden)

    Riley Mark R


    Full Text Available Abstract Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE released a document "Grand Challenges in Engineering," covering broad realms of human concern from sustainability, health, vulnerability and the joy of living. Biological engineers, having tools and techniques at the interface between living and non-living entities, will play a prominent role in forging a better future. The 2010 Institute of Biological Engineering (IBE conference in Cambridge, MA, USA will address, in part, the roles of biological engineering in solving the challenges presented by the NAE. This letter presents a brief outline of how biological engineers are working to solve these large scale and integrated problems of our society.

  10. Hierarchical structure of biological systems (United States)

    Alcocer-Cuarón, Carlos; Rivera, Ana L; Castaño, Victor M


    A general theory of biological systems, based on few fundamental propositions, allows a generalization of both Wierner and Berthalanffy approaches to theoretical biology. Here, a biological system is defined as a set of self-organized, differentiated elements that interact pair-wise through various networks and media, isolated from other sets by boundaries. Their relation to other systems can be described as a closed loop in a steady-state, which leads to a hierarchical structure and functioning of the biological system. Our thermodynamical approach of hierarchical character can be applied to biological systems of varying sizes through some general principles, based on the exchange of energy information and/or mass from and within the systems. PMID:24145961

  11. Loop Quantum Theory Applied to Biology and Nonlinear Whole Biology

    CERN Document Server

    Chang, Yi-Fang


    The loop quantum theory, which constitutes a very small discontinuous space, as new method is applied to biology. The model of protein folding and lungs is proposed. In the model, some known results are used, and four approximate conclusions are obtained: their structures are quantized, their space regions are finite, various singularities correspond to folding and crossed points, and different types of catastrophe exist. Further, based on the inseparability and correlativity of the biological systems, the nonlinear whole biology is proposed, and four basic hypotheses are formed. It may unify reductionism and holism, structuralism and functionalism. Finally, the medical meaning of the theory is discussed briefly.

  12. Biology and Economics: Metaphors that Economists usually take from Biology

    Directory of Open Access Journals (Sweden)

    Danny García Callejas


    Full Text Available Adam Smith, Alfred Marshall, Stanley Jevons, Karl Marx, Francois Quesnay and Joseph Schumpeter all have at least one thing in common: they used biological metaphors when speaking about economics. Nonetheless, today, this relation subsists and biology and economics are viewed as complementary sciences that have a lot to gain from joint research in fields like: evolutionary economics, economic growth, cognitive economics and environmental and ecological economics, among others. This paper, divided in four sections, will show this conclusion and explain that biology and economics are more sisters than strangers

  13. Biological Systems, Energy Sources, and Biology Teaching. Biology and Human Welfare. (United States)

    Tribe, Michael; Pritchard, Alan J.

    This five-chapter document (part of a series on biology and human welfare) focuses on biological systems as energy sources and on the teaching of this subject area. Chapter 1 discusses various topics related to energy and ecology, including biomass, photosynthesis and world energy balances, energy flow through ecosystems, and others. Chapter 2…

  14. Biological modulation of tectonics (United States)

    Sleep, N. H.; Bird, D. K.


    Photosynthesis has had geologic consequences over the Earth's history. In addition to modifying Earth's atmosphere and ocean chemistry, it has also modulated tectonic processes through enhanced weathering and modification of the nature and composition of sedimentary rocks within fold mountain belts and convergent margins. Molecular biological studies indicate that bacterial photosynthesis evolved just once and that most bacterial clades descend from this photosynthetic common ancestor. Iron-based photosynthesis (ideally 4FeO + CO2 + H2O = 2Fe2O3 + CH2O) was the most bountiful anoxygenic niche on land. The back reaction provided energy to heterotrophic microbes and returned FeO to the photosynthetic microbes. Bacterial land colonists evolved into ecosystems that effectively weathered FeO-bearing minerals and volcanic glass. Clays, sands, and dissolved cations from the weathering process entered the ocean and formed our familiar classes sedimentary rocks: shales, sandstones, and carbonates. Marine photosynthesis caused organic carbon to accumulate in black shales. In contrast, non-photosynthetic ecosystems do not cause organic carbon to accumulate in shale. These evolutionary events occurred before 3.8 Ga as black shales are among the oldest rock types (Rosing and Frei, Earth Planet. Sci. Lett. 217, 237-244, 2004). Thick sedimentary sequences deformed into fold mountain belts. They remelted at depth to form granitic rocks (Rosing et al., Palaeoclimatol. Palaeoecol. 232, 99-11, 2006). Regions of outcropping low-FeO rocks including granites, quartzites, and some shales were a direct result. This dearth of FeO favored the evolution of oxic photosynthesis of cyanobacteria from photosynthetic soil bacteria. Black shales have an additional modulation effect on tectonics as they concentrate radioactive elements, particularly uranium (e.g. so that the surface heat flow varies by a factor of ca. 2). Thick sequences of black shales at continental rises of passive margins are

  15. The Relationships between Epistemic Beliefs in Biology and Approaches to Learning Biology among Biology-Major University Students in Taiwan (United States)

    Lin, Yi-Chun; Liang, Jyh-Chong; Tsai, Chin-Chung


    The aim of this study was to investigate the relationships between students' epistemic beliefs in biology and their approaches to learning biology. To this end, two instruments, the epistemic beliefs in biology and the approaches to learning biology surveys, were developed and administered to 520 university biology students, respectively. By and…

  16. The meaning of biological information. (United States)

    Koonin, Eugene V


    Biological information encoded in genomes is fundamentally different from and effectively orthogonal to Shannon entropy. The biologically relevant concept of information has to do with 'meaning', i.e. encoding various biological functions with various degree of evolutionary conservation. Apart from direct experimentation, the meaning, or biological information content, can be extracted and quantified from alignments of homologous nucleotide or amino acid sequences but generally not from a single sequence, using appropriately modified information theoretical formulae. For short, information encoded in genomes is defined vertically but not horizontally. Informally but substantially, biological information density seems to be equivalent to 'meaning' of genomic sequences that spans the entire range from sharply defined, universal meaning to effective meaninglessness. Large fractions of genomes, up to 90% in some plants, belong within the domain of fuzzy meaning. The sequences with fuzzy meaning can be recruited for various functions, with the meaning subsequently fixed, and also could perform generic functional roles that do not require sequence conservation. Biological meaning is continuously transferred between the genomes of selfish elements and hosts in the process of their coevolution. Thus, in order to adequately describe genome function and evolution, the concepts of information theory have to be adapted to incorporate the notion of meaning that is central to biology.

  17. Digital 'faces' of synthetic biology. (United States)

    Friedrich, Kathrin


    In silicio design plays a fundamental role in the endeavour to synthesise biological systems. In particular, computer-aided design software enables users to manage the complexity of biological entities that is connected to their construction and reconfiguration. The software's graphical user interface bridges the gap between the machine-readable data on the algorithmic subface of the computer and its human-amenable surface represented by standardised diagrammatic elements. Notations like the Systems Biology Graphical Notation (SBGN), together with interactive operations such as drag & drop, allow the user to visually design and simulate synthetic systems as 'bio-algorithmic signs'. Finally, the digital programming process should be extended to the wet lab to manufacture the designed synthetic biological systems. By exploring the different 'faces' of synthetic biology, I argue that in particular computer-aided design (CAD) is pushing the idea to automatically produce de novo objects. Multifaceted software processes serve mutually aesthetic, epistemic and performative purposes by simultaneously black-boxing and bridging different data sources, experimental operations and community-wide standards. So far, synthetic biology is mainly a product of digital media technologies that structurally mimic the epistemological challenge to take both qualitative as well as quantitative aspects of biological systems into account in order to understand and produce new and functional entities.

  18. Synthetic biology and metabolic engineering. (United States)

    Stephanopoulos, Gregory


    Metabolic engineering emerged 20 years ago as the discipline occupied with the directed modification of metabolic pathways for the microbial synthesis of various products. As such, it deals with the engineering (design, construction, and optimization) of native as well as non-natural routes of product synthesis, aided in this task by the availability of synthetic DNA, the core enabling technology of synthetic biology. The two fields, however, only partially overlap in their interest in pathway engineering. While fabrication of biobricks, synthetic cells, genetic circuits, and nonlinear cell dynamics, along with pathway engineering, have occupied researchers in the field of synthetic biology, the sum total of these areas does not constitute a coherent definition of synthetic biology with a distinct intellectual foundation and well-defined areas of application. This paper reviews the origins of the two fields and advances two distinct paradigms for each of them: that of unit operations for metabolic engineering and electronic circuits for synthetic biology. In this context, metabolic engineering is about engineering cell factories for the biological manufacturing of chemical and pharmaceutical products, whereas the main focus of synthetic biology is fundamental biological research facilitated by the use of synthetic DNA and genetic circuits.

  19. Synthetic biology as red herring. (United States)

    Preston, Beth


    It has become commonplace to say that with the advent of technologies like synthetic biology the line between artifacts and living organisms, policed by metaphysicians since antiquity, is beginning to blur. But that line began to blur 10,000 years ago when plants and animals were first domesticated; and has been thoroughly blurred at least since agriculture became the dominant human subsistence pattern many millennia ago. Synthetic biology is ultimately only a late and unexceptional offshoot of this prehistoric development. From this perspective, then, synthetic biology is a red herring, distracting us from more thorough philosophical consideration of the most truly revolutionary human practice-agriculture. In the first section of this paper I will make this case with regard to ontology, arguing that synthetic biology crosses no ontological lines that were not crossed already in the Neolithic. In the second section I will construct a parallel case with regard to cognition, arguing that synthetic biology as biological engineering represents no cognitive advance over what was required for domestication and the new agricultural subsistence pattern it grounds. In the final section I will make the case with regard to human existence, arguing that synthetic biology, even if wildly successful, is not in a position to cause significant existential change in what it is to be human over and above the massive existential change caused by the transition to agriculture. I conclude that a longer historical perspective casts new light on some important issues in philosophy of technology and environmental philosophy.

  20. Fostering synergy between cell biology and systems biology. (United States)

    Eddy, James A; Funk, Cory C; Price, Nathan D


    In the shared pursuit of elucidating detailed mechanisms of cell function, systems biology presents a natural complement to ongoing efforts in cell biology. Systems biology aims to characterize biological systems through integrated and quantitative modeling of cellular information. The process of model building and analysis provides value through synthesizing and cataloging information about cells and molecules, predicting mechanisms and identifying generalizable themes, generating hypotheses and guiding experimental design, and highlighting knowledge gaps and refining understanding. In turn, incorporating domain expertise and experimental data is crucial for building towards whole cell models. An iterative cycle of interaction between cell and systems biologists advances the goals of both fields and establishes a framework for mechanistic understanding of the genome-to-phenome relationship.

  1. Agroterrorism, Biological Crimes, and Biological Warfare Targeting Animal Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Terry M.; Logan-Henfrey, Linda; Weller, Richard E.; Kellman, Brian


    There is a rising level of concern that agriculture might be targeted for economic sabotage by terrorists. Knowledge gathered about the Soviet Union biological weapons program and Iraq following the Gulf War, confirmed that animals and agricultural crops were targets of bioweapon development. These revelations are particularly disturbing in light of the fact that both countries are States Parties to the Biological and Toxin Weapons Convention that entered into force in 1975. The potential for misusing biotechnology to create more virulent pathogens and the lack of international means to detect unethical uses of new technologies to create destructive bioweapons is of increasing concern. Disease outbreaks, whether naturally occurring or intentionally, involving agricultural pathogens that destroy livestock and crops would have a profound impact on a country's infrastructure, economy and export markets. This chapter deals with the history of agroterrorism, biological crimes and biological warfare directed toward animal agriculture, specifically, horses, cattle, swine, sheep, goats, and poultry.

  2. Marine molecular biology: An emerging field of biological sciences

    Digital Repository Service at National Institute of Oceanography (India)

    Thakur, N.L.; Jain, R.; Natalio, F.; Hamer, B.; Thakur, A.N.; Muller, W.E.G.

    to tackle problems associated with global climate changes, bio- diversity, environmental quality and use of marine living re- sources (Molecular biology in marine science, 1994). Marine biologists study oceanic life in relation to marine environment... that often range from small to global scale, whereas, molecular biologist study biological events in terms of the physiochemical properties of molecules. The immediate benefits of the collab- orative research between these two disciplines could include...

  3. Biological Databases for Human Research

    Institute of Scientific and Technical Information of China (English)

    Dong Zou; Lina Ma; Jun Yu; Zhang Zhang


    The completion of the Human Genome Project lays a foundation for systematically studying the human genome from evolutionary history to precision medicine against diseases. With the explosive growth of biological data, there is an increasing number of biological databases that have been developed in aid of human-related research. Here we present a collection of human-related biological databases and provide a mini-review by classifying them into different categories according to their data types. As human-related databases continue to grow not only in count but also in volume, challenges are ahead in big data storage, processing, exchange and curation.

  4. The Ethics of Synthetic Biology

    DEFF Research Database (Denmark)

    Christiansen, Andreas

    The dissertation analyses and discusses a number of ethical issues that have been raised in connection with the development of synthetic biology. Synthetic biology is a set of new techniques for DNA-level design and construction of living beings with useful properties. The dissertation especially......) popular responsesto them succeed, and whether the objections are ultimately persuasive.2. Given that synthetic biology is a new technology, there is a certain degree of uncertainty about its ultimate effects, and many perceive the technology as risky. I discuss two common approaches in risk regulation...

  5. Bilingual teaching of molecular biology

    Institute of Scientific and Technical Information of China (English)


    Recently bilingual teaching in China's universities has been widely carried out and become a popular subject for study. In this paper, the reasons for bilingual teaching of molecular biology are pointed out, the textbook of molecular biology and teaching method in bilingual teaching classes are determined after investigation and the practice of bilingually teaching molecular biology use both English and Chinese in a class. The effect has proved good. The bilingual teaching methods, the problem of bilingual teaching, the importance of understanding its significance and the possibilities of improving such teaching of the subject are also discussed.

  6. The renaissance of developmental biology. (United States)

    St Johnston, Daniel


    Since its heyday in the 1980s and 90s, the field of developmental biology has gone into decline; in part because it has been eclipsed by the rise of genomics and stem cell biology, and in part because it has seemed less pertinent in an era with so much focus on translational impact. In this essay, I argue that recent progress in genome-wide analyses and stem cell research, coupled with technological advances in imaging and genome editing, have created the conditions for the renaissance of a new wave of developmental biology with greater translational relevance.

  7. Ten questions about systems biology

    DEFF Research Database (Denmark)

    Joyner, Michael J; Pedersen, Bente K


    to understand how whole animals adapt to the real world. We argue that a lack of fluency in these concepts is a major stumbling block for what has been narrowly defined as 'systems biology' by some of its leading advocates. We also point out that it is a failure of regulation at multiple levels that causes many......In this paper we raise 'ten questions' broadly related to 'omics', the term systems biology, and why the new biology has failed to deliver major therapeutic advances for many common diseases, especially diabetes and cardiovascular disease. We argue that a fundamentally narrow and reductionist...

  8. Basic radiotherapy physics and biology

    CERN Document Server

    Chang, David S; Das, Indra J; Mendonca, Marc S; Dynlacht, Joseph R


    This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a

  9. Biological Optimisation for Nurse Scheduling

    CERN Document Server

    Twycross, Jamie


    Artificial immune systems (AISs) to date have generally been inspired by naive biological metaphors. This has limited the effectiveness of these systems. In this position paper two ways in which AISs could be made more biologically realistic are discussed. We propose that AISs should draw their inspiration from organisms which possess only innate immune systems, and that AISs should employ systemic models of the immune system to structure their overall design. An outline of plant and invertebrate immune systems is presented, and a number of contemporary research that more biologically-realistic AISs could have is also discussed.

  10. Robust design of biological circuits: evolutionary systems biology approach. (United States)

    Chen, Bor-Sen; Hsu, Chih-Yuan; Liou, Jing-Jia


    Artificial gene circuits have been proposed to be embedded into microbial cells that function as switches, timers, oscillators, and the Boolean logic gates. Building more complex systems from these basic gene circuit components is one key advance for biologic circuit design and synthetic biology. However, the behavior of bioengineered gene circuits remains unstable and uncertain. In this study, a nonlinear stochastic system is proposed to model the biological systems with intrinsic parameter fluctuations and environmental molecular noise from the cellular context in the host cell. Based on evolutionary systems biology algorithm, the design parameters of target gene circuits can evolve to specific values in order to robustly track a desired biologic function in spite of intrinsic and environmental noise. The fitness function is selected to be inversely proportional to the tracking error so that the evolutionary biological circuit can achieve the optimal tracking mimicking the evolutionary process of a gene circuit. Finally, several design examples are given in silico with the Monte Carlo simulation to illustrate the design procedure and to confirm the robust performance of the proposed design method. The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise.

  11. Systems biology of human atherosclerosis. (United States)

    Shalhoub, Joseph; Sikkel, Markus B; Davies, Kerry J; Vorkas, Panagiotis A; Want, Elizabeth J; Davies, Alun H


    Systems biology describes a holistic and integrative approach to understand physiology and pathology. The "omic" disciplines include genomics, transcriptomics, proteomics, and metabolic profiling (metabonomics and metabolomics). By adopting a stance, which is opposing (yet complimentary) to conventional research techniques, systems biology offers an overview by assessing the "net" biological effect imposed by a disease or nondisease state. There are a number of different organizational levels to be understood, from DNA to protein, metabolites, cells, organs and organisms, even beyond this to an organism's context. Systems biology relies on the existence of "nodes" and "edges." Nodes are the constituent part of the system being studied (eg, proteins in the proteome), while the edges are the way these constituents interact. In future, it will be increasingly important to collaborate, collating data from multiple studies to improve data sets, making them freely available and undertaking integrative analyses.

  12. VT Biodiversity Project - Biological Hotspots (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This dataset is the result of an effort to map biological "hotspots" in Vermont based on the "element occurrences" in the Nongame and Natural...

  13. Quivira NWR biological baseline data (United States)

    US Fish and Wildlife Service, Department of the Interior — This dataset is biological baseline data for Quivira National Wildlife Refuge as of January 2016. It contains data on species found on the refuge, when and where...

  14. Sex and the Biology Teacher (United States)

    Keller, Dolores Elaine


    Summarizes evidence that mammals are basically female, with masculine characteristics being imposed by hormonal changes in embryos or post-natally. Advocates the removal of male-dominant terminology in biological research and teaching. (AL)

  15. Synthetic Biology for Specialty Chemicals. (United States)

    Markham, Kelly A; Alper, Hal S


    In this review, we address recent advances in the field of synthetic biology and describe how those tools have been applied to produce a wide variety of chemicals in microorganisms. Here we classify the expansion of the synthetic biology toolbox into three different categories based on their primary function in strain engineering-for design, for construction, and for optimization. Next, focusing on recent years, we look at how chemicals have been produced using these new synthetic biology tools. Advances in producing fuels are briefly described, followed by a more thorough treatment of commodity chemicals, specialty chemicals, pharmaceuticals, and nutraceuticals. Throughout this review, an emphasis is placed on how synthetic biology tools are applied to strain engineering. Finally, we discuss organism and host strain diversity and provide a future outlook in the field.

  16. Systems biology and cardiac arrhythmias. (United States)

    Grace, Andrew A; Roden, Dan M


    During the past few years, the development of effective, empirical technologies for treatment of cardiac arrhythmias has exceeded the pace at which detailed knowledge of the underlying biology has accumulated. As a result, although some clinical arrhythmias can be cured with techniques such as catheter ablation, drug treatment and prediction of the risk of sudden death remain fairly primitive. The identification of key candidate genes for monogenic arrhythmia syndromes shows that to bring basic biology to the clinic is a powerful approach. Increasingly sophisticated experimental models and methods of measurement, including stem cell-based models of human cardiac arrhythmias, are being deployed to study how perturbations in several biologic pathways can result in an arrhythmia-prone heart. The biology of arrhythmia is largely quantifiable, which allows for systematic analysis that could transform treatment strategies that are often still empirical into management based on molecular evidence.

  17. Aging and computational systems biology. (United States)

    Mooney, Kathleen M; Morgan, Amy E; Mc Auley, Mark T


    Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrinsic interactions, while also attempting to account for the impact of external inputs, such as diet. A key technique employed in systems biology is computational modeling, which involves mathematically describing and simulating the dynamics of biological systems. Although a large number of computational models have been developed in recent years, these models have focused on various discrete components of the aging process, and to date no model has succeeded in completely representing the full scope of aging. Combining existing models or developing new models may help to address this need and in so doing could help achieve an improved understanding of the intrinsic mechanisms which underpin aging.

  18. Inference problems in structural biology

    DEFF Research Database (Denmark)

    Olsson, Simon

    The structure and dynamics of biological molecules are essential for their function. Consequently, a wealth of experimental techniques have been developed to study these features. However, while experiments yield detailed information about geometrical features of molecules, this information is of...

  19. The relativity of biological function. (United States)

    Laubichler, Manfred D; Stadler, Peter F; Prohaska, Sonja J; Nowick, Katja


    Function is a central concept in biological theories and explanations. Yet discussions about function are often based on a narrow understanding of biological systems and processes, such as idealized molecular systems or simple evolutionary, i.e., selective, dynamics. Conflicting conceptions of function continue to be used in the scientific literature to support certain claims, for instance about the fraction of "functional DNA" in the human genome. Here we argue that all biologically meaningful interpretations of function are necessarily context dependent. This implies that they derive their meaning as well as their range of applicability only within a specific theoretical and measurement context. We use this framework to shed light on the current debate about functional DNA and argue that without considering explicitly the theoretical and measurement contexts all attempts to integrate biological theories are prone to fail.

  20. Text mining for systems biology. (United States)

    Fluck, Juliane; Hofmann-Apitius, Martin


    Scientific communication in biomedicine is, by and large, still text based. Text mining technologies for the automated extraction of useful biomedical information from unstructured text that can be directly used for systems biology modelling have been substantially improved over the past few years. In this review, we underline the importance of named entity recognition and relationship extraction as fundamental approaches that are relevant to systems biology. Furthermore, we emphasize the role of publicly organized scientific benchmarking challenges that reflect the current status of text-mining technology and are important in moving the entire field forward. Given further interdisciplinary development of systems biology-orientated ontologies and training corpora, we expect a steadily increasing impact of text-mining technology on systems biology in the future.

  1. Language from a biological perspective

    Indian Academy of Sciences (India)

    Mohinish Shukla


    The faculty of language is unique to the human species. This implies that there are human-specific biological changes that lie at the basis of human language. However, it is not clear what the nature of such changes are, and how they could be shaped by evolution. In this paper, emphasis is laid on describing language in a Chomskyan manner, as a mental object. This serves as a standpoint to speculate about the biological basis of the emergence and evolution of language.

  2. Feller's Contributions to Mathematical Biology


    Baake, Ellen; Wakolbinger, Anton


    This is a review of William Feller's important contributions to mathematical biology. The seminal paper [Feller1951] "Diffusion processes in genetics" was particularly influential on the development of stochastic processes at the interface to evolutionary biology, and interesting ideas in this direction (including a first characterization of what is nowadays known as "Feller's branching diffusion") already shaped up in the paper [Feller 1939] (written in German) "The foundations of a probabis...

  3. How physics can inspire biology (United States)

    Kornyshev, Alexei


    In July 1997 Adrian Parsegian, a biophysicist at the National Institutes of Health in the US and a former president of the Biophysical Society, published an article in Physics Today in which he outlined his thoughts about the main obstacles to a happy marriage between physics and biology. Parsegian started his article with a joke about a physicist talking to his biology-trained friend.

  4. Biological Effects of Acoustic Cavitation (United States)


    rectified diffusion. 56 III. STABLE CAVITATION A. Introduction There are manv areas associated with the biological effects of ultrasound in which the...used said as cavitation indicators. Further, if clinical ultrasound systems are found to be inducing cavitation , either stable or transient, it will...O BIOLOGICAL EFFECTS OF ACOUSTIC CAVITATION by Lawrence A. Crum -- Physical Acoustics Research Laboratory Department of Physics and Astronomy ’ CTE

  5. Researchers Discover Plants Biological Clock

    Institute of Scientific and Technical Information of China (English)



    Scientists who created glow-in-the-dark plants by shooting up seedlingswith firefly DNA have identified the first biological clock gene in plants. Discovery of the timepiece gene, which controls such biological rhythmsas daily leaf movements and proe openings, flower-blooming schedules andphotosynthesis cycles, could lead to a host of applications in ornamental horti-culture, agriculture and even human health. Many researchers believe that

  6. Nanoscale technology in biological systems

    CERN Document Server

    Greco, Ralph S; Smith, R Lane


    Reviewing recent accomplishments in the field of nanobiology Nanoscale Technology in Biological Systems introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular communication at the molecular level. It also explores the application of nanobiology to cardiovascular diseases, oncology, transplantation, and a range of related disciplines. This book build a strong background in nanotechnology and nanobiology ideal for

  7. US Competitiveness in Synthetic Biology. (United States)

    Gronvall, Gigi Kwik


    Synthetic biology is an emerging technical field that aims to make biology easier to engineer; the field has applications in strategically important sectors for the US economy. While the United States currently leads in synthetic biology R&D, other nations are heavily investing in order to boost their economies, which will inevitably diminish the US leadership position. This outcome is not entirely negative--additional investments will expand markets--but it is critical that the US government take steps to remain competitive: There are applications from which the US population and economy may benefit; there are specific applications with importance for national defense; and US technical leadership will ensure that US experts have a leading role in synthetic biology governance, regulation, and oversight. Measures to increase competitiveness in S&T generally are broadly applicable for synthetic biology and should be pursued. However, the US government will also need to take action on fundamental issues that will affect the field's development, such as countering anti-GMO (genetically modified organism) sentiments and anti-GMO legislation. The United States should maintain its regulatory approach so that it is the product that is regulated, not the method used to create a product. At the same time, the United States needs to ensure that the regulatory framework is updated so that synthetic biology products do not fall into regulatory gaps. Finally, the United States needs to pay close attention to how synthetic biology applications may be governed internationally, such as through the Nagoya Protocol of the Convention on Biological Diversity, so that beneficial applications may be realized.

  8. Issues in Biological Shape Modelling

    DEFF Research Database (Denmark)

    Hilger, Klaus Baggesen

    This talk reflects parts of the current research at informatics and Mathematical Modelling at the Technical University of Denmark within biological shape modelling. We illustrate a series of generalizations, modifications, and applications of the elements of constructing models of shape or appear......This talk reflects parts of the current research at informatics and Mathematical Modelling at the Technical University of Denmark within biological shape modelling. We illustrate a series of generalizations, modifications, and applications of the elements of constructing models of shape...

  9. US Competitiveness in Synthetic Biology (United States)


    Synthetic biology is an emerging technical field that aims to make biology easier to engineer; the field has applications in strategically important sectors for the US economy. While the United States currently leads in synthetic biology R&D, other nations are heavily investing in order to boost their economies, which will inevitably diminish the US leadership position. This outcome is not entirely negative—additional investments will expand markets—but it is critical that the US government take steps to remain competitive: There are applications from which the US population and economy may benefit; there are specific applications with importance for national defense; and US technical leadership will ensure that US experts have a leading role in synthetic biology governance, regulation, and oversight. Measures to increase competitiveness in S&T generally are broadly applicable for synthetic biology and should be pursued. However, the US government will also need to take action on fundamental issues that will affect the field's development, such as countering anti-GMO (genetically modified organism) sentiments and anti-GMO legislation. The United States should maintain its regulatory approach so that it is the product that is regulated, not the method used to create a product. At the same time, the United States needs to ensure that the regulatory framework is updated so that synthetic biology products do not fall into regulatory gaps. Finally, the United States needs to pay close attention to how synthetic biology applications may be governed internationally, such as through the Nagoya Protocol of the Convention on Biological Diversity, so that beneficial applications may be realized. PMID:26690379

  10. The aesthetics of chemical biology. (United States)

    Parsons, Glenn


    Scientists and philosophers have long reflected on the place of aesthetics in science. In this essay, I review these discussions, identifying work of relevance to chemistry and, in particular, to the field of chemical biology. Topics discussed include the role of aesthetics in scientific theory choice, the aesthetics of molecular images, the beauty-making features of molecules, and the relation between the aesthetics of chemical biology and the aesthetics of industrial design.

  11. Market study: Biological isolation garment (United States)


    The biological isolation garment was originally designed for Apollo astronauts to wear upon their return to earth from the moon to avoid the possibility of their contaminating the environment. The concept has been adapted for medical use to protect certain patients from environmental contamination and the risk of infection. The nature and size of the anticipated market are examined with certain findings and conclusions relative to clinical acceptability and potential commercial viability of the biological isolation garment.

  12. Biological Activities of Hydrazone Derivatives

    Directory of Open Access Journals (Sweden)

    S. Güniz Küçükgüzel


    Full Text Available There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

  13. Biological markets explain human ultrasociality. (United States)

    Sheskin, Mark; Lambert, Stéphane; Baumard, Nicolas


    The evidence Gowdy & Krall (G&K) provide is more consistent with a biological markets explanation of human ultrasociality than a group selection explanation. Specifically, large-scale societies provide a better biological market for cooperation than do small-scale societies, allowing individuals to increase their fitness. Importantly, many of the quality-of-life costs G&K discuss (e.g., patriarchy) are not fitness costs.

  14. Biological atomism and cell theory. (United States)

    Nicholson, Daniel J


    Biological atomism postulates that all life is composed of elementary and indivisible vital units. The activity of a living organism is thus conceived as the result of the activities and interactions of its elementary constituents, each of which individually already exhibits all the attributes proper to life. This paper surveys some of the key episodes in the history of biological atomism, and situates cell theory within this tradition. The atomistic foundations of cell theory are subsequently dissected and discussed, together with the theory's conceptual development and eventual consolidation. This paper then examines the major criticisms that have been waged against cell theory, and argues that these too can be interpreted through the prism of biological atomism as attempts to relocate the true biological atom away from the cell to a level of organization above or below it. Overall, biological atomism provides a useful perspective through which to examine the history and philosophy of cell theory, and it also opens up a new way of thinking about the epistemic decomposition of living organisms that significantly departs from the physicochemical reductionism of mechanistic biology.

  15. Where Synthetic Biology Meets ET (United States)

    Rothschild, Lynn J.


    Synthetic biology - the design and construction of new biological parts and systems and the redesign of existing ones for useful purposes - has the potential to transform fields from pharmaceuticals to fuels. Our lab has focused on the potential of synthetic biology to revolutionize all three major parts of astrobiology: Where do we come from? Where are we going? and Are we alone? For the first and third, synthetic biology is allowing us to answer whether the evolutionary narrative that has played out on planet earth is likely to have been unique or universal. For example, in our lab we are re-evolving the biosynthetic pathways of amino acids in order to understand potential capabilities of an early organism with a limited repertoire of amino acids and developing techniques for the recovery of metals from spent electronics on other planetary bodies. And what about the limits for life? Can we create organisms that expand the envelope for life? In the future synthetic biology will play an increasing role in human activities both on earth, in fields as diverse as human health and the industrial production of novel bio-composites. Beyond earth, we will rely increasingly on biologically-provided life support, as we have throughout our evolutionary history. In order to do this, the field will build on two of the great contributions of astrobiology: studies of the origin of life and life in extreme environments.

  16. Molecular biology of the cell

    CERN Document Server

    Alberts, Bruce; Lewis, Julian


    Molecular Biology of the Cell is the classic in-dept text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept...

  17. Synthetic biology and personalized medicine. (United States)

    Jain, K K


    Synthetic biology, application of synthetic chemistry to biology, is a broad term that covers the engineering of biological systems with structures and functions not found in nature to process information, manipulate chemicals, produce energy, maintain cell environment and enhance human health. Synthetic biology devices contribute not only to improve our understanding of disease mechanisms, but also provide novel diagnostic tools. Methods based on synthetic biology enable the design of novel strategies for the treatment of cancer, immune diseases metabolic disorders and infectious diseases as well as the production of cheap drugs. The potential of synthetic genome, using an expanded genetic code that is designed for specific drug synthesis as well as delivery and activation of the drug in vivo by a pathological signal, was already pointed out during a lecture delivered at Kuwait University in 2005. Of two approaches to synthetic biology, top-down and bottom-up, the latter is more relevant to the development of personalized medicines as it provides more flexibility in constructing a partially synthetic cell from basic building blocks for a desired task.

  18. Biologic Therapy (Immunotherapy) for Kidney Cancer (United States)

    ... Stage for Kidney Cancer Kidney Cancer Treating Kidney Cancer Biologic Therapy (Immunotherapy) for Kidney Cancer The goal of biologic therapy ... Therapy for Kidney Cancer Targeted Therapies for Kidney Cancer Biologic Therapy (Immunotherapy) for Kidney Cancer Chemotherapy for Kidney Cancer Pain ...

  19. A bridge between chemistry and biology. (United States)

    Kikuchi, Kazuya; Kakeya, Hideaki


    Chemical biology is an interdisciplinary field that is undergoing rapid expansion around the globe. Recently, the Japanese Society for Chemical Biology sponsored its inaugural scientific meeting to discuss research at the interface of chemistry and biology.

  20. Biological couplings: Classification and characteristic rules

    Institute of Scientific and Technical Information of China (English)


    The phenomena that biological functions originate from biological coupling are the important biological foundation of multiple bionics and the significant discoveries in the bionic fields. In this paper, the basic concepts related to biological coupling are introduced from the bionic viewpoint. Constitution, classification and characteristic rules of biological coupling are illuminated, the general modes of biological coupling studies are analyzed, and the prospects of multi-coupling bionics are predicted.

  1. Marine biology, intertidal ecology, and a new place for biology. (United States)

    Benson, Keith R


    At the present time, there is considerable interest for the physical setting of science, that is, its actual 'place' of practice. Among historians of biology, place has been considered to be a crucial component for the study of ecology. Other historians have noted the 'built' environments (laboratories) for the study of biology along the seashore, even referring to these places in terms more applicable to vacation sites. In this paper, I examine the place of intertidal ecology investigations, both in terms of the physical space and the built space. Part of the examination will investigate the aesthetic aspect of the Pacific Coast, part will evaluate the unique character of the intertidal zone, and part will consider the construction of natural laboratories and built laboratories as characteristic places for biology.

  2. In silico cell biology and biochemistry: a systems biology approach


    Camacho, Diogo Mayo


    In the post-"omic" era the analysis of high-throughput data is regarded as one of the major challenges faced by researchers. One focus of this data analysis is uncovering biological network topologies and dynamics. It is believed that this kind of research will allow the development of new mathematical models of biological systems as well as aid in the improvement of already existing ones. The work that is presented in this dissertation addresses the problem of the analysis of highly complex ...

  3. Biological pest control in Mexico. (United States)

    Williams, Trevor; Arredondo-Bernal, Hugo C; Rodríguez-del-Bosque, Luis A


    Mexico is a megadiverse country that forms part of the Mesoamerican biological corridor that connects North and South America. Mexico's biogeographical situation places it at risk from invasive exotic insect pests that enter from the United States, Central America, or the Caribbean. In this review we analyze the factors that contributed to some highly successful past programs involving classical biological control and/or the sterile insect technique (SIT). The present situation is then examined with reference to biological control, including SIT programs, targeted at seven major pests, with varying degrees of success. Finally, we analyze the current threats facing Mexico's agriculture industry from invasive pests that have recently entered the country or are about to do so. We conclude that despite a number of shortcomings, Mexico is better set to develop biological control-based pest control programs, particularly on an area-wide basis, than many other Latin American countries are. Classical and augmentative biological control and SIT-based programs are likely to provide effective and sustainable options for control of native and exotic pests, particularly when integrated into technology packages that meet farmers' needs across the great diversity of production systems in Mexico.

  4. Biologic therapy of rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Damjanov Nemanja


    Full Text Available Rheumatoid arthritis (RA and juvenile idiopathic/rheumatoid arthritis (JIA are chronic, inflammatory, systemic, auto-immune diseases characterized by chronic arthritis leading to progressive joint erosions. The individual functional and social impact of rheumatoid arthritis is of great importance. Disability and joint damage occur rapidly and early in the course of the disease. The remarkably improved outcomes have been achieved initiating biologic therapy with close monitoring of disease progression. Biologic agents are drugs, usually proteins, which can influence chronic immune dysregulation resulting in chronic arthritis. According to the mechanism of action these drugs include: 1 anti-TNF drugs (etanercept, infiximab, adalimumab; 2 IL-1 blocking drugs (anakinra; 3 IL-6 blocking drugs (tocilizumab; 4 agents blocking selective co-stimulation modulation (abatacept; 5 CD 20 blocking drugs (rituximab. Biologics targeting TNF-alpha with methotrexate have revolutionized the treatment of RA, producing significant improvement in clinical, radiographic, and functional outcomes not seen previously. The new concept of rheumatoid arthritis treatment defines early diagnosis, early aggressive therapy with optimal doses of disease modifying antirheumatic drugs (DMARDs and, if no improvement has been achieved during six months, early introduction of biologic drugs. The three-year experience of biologic therapy in Serbia has shown a positive effect on disease outcome.

  5. Mathematical models in biological discovery

    CERN Document Server

    Walter, Charles


    When I was asked to help organize an American Association for the Advancement of Science symposium about how mathematical models have con­ tributed to biology, I agreed immediately. The subject is of immense importance and wide-spread interest. However, too often it is discussed in biologically sterile environments by "mutual admiration society" groups of "theoreticians", many of whom have never seen, and most of whom have never done, an original scientific experiment with the biolog­ ical materials they attempt to describe in abstract (and often prejudiced) terms. The opportunity to address the topic during an annual meeting of the AAAS was irresistable. In order to try to maintain the integrity ;,f the original intent of the symposium, it was entitled, "Contributions of Mathematical Models to Biological Discovery". This symposium was organized by Daniel Solomon and myself, held during the 141st annual meeting of the AAAS in New York during January, 1975, sponsored by sections G and N (Biological and Medic...

  6. Biological width: No violation zone

    Directory of Open Access Journals (Sweden)

    Ashu Sharma


    Full Text Available Maintenance of gingival health is one of the keys for the longevity of teeth, as well as for the longevity of restorations. The concept of Biologic width has been widely described by periodontists and restorative dentists. An adequate understanding of relationship between periodontal tissues and restorative dentistry is paramount to ensure adequate form, function and esthetics, and comfort of the dentition. While most clinicians are aware of this important relationship, uncertainty remains regarding specific concepts such as biologic width and indications and applications of surgical crown lengthening. These violations lead to complications like gingival inflammation, alveolar bone loss and improper fit of the restorative component. This review gives the wide aspect of the complex question of biologic width and represents an attempt to answer some of the demands in relation to it. The article also discusses the possible methods to assess biologic width, problems that occur after improper margin placement in the periodontium and the alternative procedures for prevention of biological width violation.

  7. Circadian systems biology in Metazoa. (United States)

    Lin, Li-Ling; Huang, Hsuan-Cheng; Juan, Hsueh-Fen


    Systems biology, which can be defined as integrative biology, comprises multistage processes that can be used to understand components of complex biological systems of living organisms and provides hierarchical information to decoding life. Using systems biology approaches such as genomics, transcriptomics and proteomics, it is now possible to delineate more complicated interactions between circadian control systems and diseases. The circadian rhythm is a multiscale phenomenon existing within the body that influences numerous physiological activities such as changes in gene expression, protein turnover, metabolism and human behavior. In this review, we describe the relationships between the circadian control system and its related genes or proteins, and circadian rhythm disorders in systems biology studies. To maintain and modulate circadian oscillation, cells possess elaborative feedback loops composed of circadian core proteins that regulate the expression of other genes through their transcriptional activities. The disruption of these rhythms has been reported to be associated with diseases such as arrhythmia, obesity, insulin resistance, carcinogenesis and disruptions in natural oscillations in the control of cell growth. This review demonstrates that lifestyle is considered as a fundamental factor that modifies circadian rhythm, and the development of dysfunctions and diseases could be regulated by an underlying expression network with multiple circadian-associated signals.

  8. Kinetic Modeling of Biological Systems

    Energy Technology Data Exchange (ETDEWEB)

    Resat, Haluk; Petzold, Linda; Pettigrew, Michel F.


    The dynamics of how its constituent components interact define the spatio-temporal response of a natural system to stimuli. Modeling the kinetics of the processes that represent a biophysical system has long been pursued with the aim of improving our understanding of the studied system. Due to the unique properties of biological systems, in addition to the usual difficulties faced in modeling the dynamics of physical or chemical systems, biological simulations encounter difficulties that result from intrinsic multiscale and stochastic nature of the biological processes. This chapter discusses the implications for simulation of models involving interacting species with very low copy numbers, which often occur in biological systems and give rise to significant relative fluctuations. The conditions necessitating the use of stochastic kinetic simulation methods and the mathematical foundations of the stochastic simulation algorithms are presented. How the well-organized structural hierarchies often seen in biological systems can lead to multiscale problems, and possible ways to address the encountered computational difficulties are discussed. We present the details of the existing kinetic simulation methods, and discuss their strengths and shortcomings. A list of the publicly available kinetic simulation tools and our reflections for future prospects are also provided.

  9. Theoretical aspects of Systems Biology. (United States)

    Bizzarri, Mariano; Palombo, Alessandro; Cucina, Alessandra


    The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond. This implies that, in order to explain the features and behavior of a whole system, a theory might be required that would operate at the corresponding hierarchical level, i.e. where self-organization processes take place. In the past, biological research has focused on questions that could be answered by a reductionist program of genetics. The organism (and its development) was considered an epiphenomenona of its genes. However, a profound rethinking of the biological paradigm is now underway and it is likely that such a process will lead to a conceptual revolution emerging from the ashes of reductionism. This revolution implies the search for general principles on which a cogent theory of biology might rely. Because much of the logic of living systems is located at higher levels, it is imperative to focus on them. Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a 'simple' 'gradual' extension of Molecular Biology.

  10. Coincidence in the dose estimation in a OEP by different methods; Coincidencia en la estimacion de dosis en un POE por diferentes metodos

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Arceo M, C.; Brena V, M. [ININ, Km. 36.5, Carretera Mexico-Toluca, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail:


    The case of an apparent overexposure to radiation according to that indicated for the thermoluminescent dosemeter 81.59 mSv (TLD) of a occupationally exposed hard-working (POE), for that was practiced the study of biological dosimetry. The estimated dose was 0.12 Gy with which was proven the marked dose registration by the TLD dosemeter. It was concluded that both doses are the same ones. (Author)

  11. [Biological experiments on "Kosmos-1887"]. (United States)

    Alpatov, A M; I'lin, E A; Antipov, V V; Tairbekov, M G


    In the 13-ray space flight on Kosmos-1887 various experiments in the field of cell biology, genetics, biorhythm, developmental biology and regeneration were performed using bacteria, protozoa, plants, worms, insects, fish and amphibia. Paramecia showed enhanced cell proliferation, spheroidization and diminished protein content. Experiments on fruit-flies, newt oocytes and primate lymphocytes confirmed involvement of the cell genetic apparatus in responses to microgravity. Beetles exhibited a reduction of the length of the spontaneous period of freely running circadian rhythms. Carausius morosus developed latent changes in early embryogenesis which manifested at later stages of ontogenesis. Exposure to microgravity did not prevent recovery of injured tissues; moreover their regeneration may be accelerated after recovery. Biology research programs in future biosatellite flights are discussed.

  12. The mathematics behind biological invasions

    CERN Document Server

    Lewis, Mark A; Potts, Jonathan R


    This book investigates the mathematical analysis of biological invasions. Unlike purely qualitative treatments of ecology, it draws on mathematical theory and methods, equipping the reader with sharp tools and rigorous methodology. Subjects include invasion dynamics, species interactions, population spread, long-distance dispersal, stochastic effects, risk analysis, and optimal responses to invaders. While based on the theory of dynamical systems, including partial differential equations and integrodifference equations, the book also draws on information theory, machine learning, Monte Carlo methods, optimal control, statistics, and stochastic processes. Applications to real biological invasions are included throughout. Ultimately, the book imparts a powerful principle: that by bringing ecology and mathematics together, researchers can uncover new understanding of, and effective response strategies to, biological invasions. It is suitable for graduate students and established researchers in mathematical ecolo...

  13. Biological Remediation of Petroleum Contaminants (United States)

    Kuhad, Ramesh Chander; Gupta, Rishi

    Large volumes of hazardous wastes are generated in the form of oily sludges and contaminated soils during crude oil transportation and processing. Although many physical, chemical and biological treatment technologies are available for petroleum contaminants petroleum contaminants in soil, biological methods have been considered the most cost-effective. Practical biological remediation methods typically involve direct use of the microbes naturally occurring in the contaminated environment and/or cultured indigenous or modified microorganisms. Environmental and nutritional factors, including the properties of the soil, the chemical structure of the hydrocarbon(s), oxygen, water, nutrient availability, pH, temperature, and contaminant bioavailability, can significantly affect the rate and the extent of hydrocarbon biodegradation hydrocarbon biodegradation by microorganisms in contaminated soils. This chapter concisely discusses the major aspects of bioremediation of petroleum contaminants.

  14. The Dark Matter of Biology. (United States)

    Ross, Jennifer L


    The inside of the cell is full of important, yet invisible species of molecules and proteins that interact weakly but couple together to have huge and important effects in many biological processes. Such "dark matter" inside cells remains mostly hidden, because our tools were developed to investigate strongly interacting species and folded proteins. Example dark-matter species include intrinsically disordered proteins, posttranslational states, ion species, and rare, transient, and weak interactions undetectable by biochemical assays. The dark matter of biology is likely to have multiple, vital roles to regulate signaling, rates of reactions, water structure and viscosity, crowding, and other cellular activities. We need to create new tools to image, detect, and understand these dark-matter species if we are to truly understand fundamental physical principles of biology.

  15. Vitalism in naive biological thinking. (United States)

    Morris, S C; Taplin, J E; Gelman, S A


    Vitalism is the belief that internal bodily organs have agency and that they transmit or exchange a vital force or energy. Three experiments investigated the use of vitalistic explanations for biological phenomena by 5- and 10-year-old English-speaking children and adults, focusing on 2 components: the notion that bodily organs have intentions and the notion that some life force or energy is transmitted. The original Japanese finding of vitalistic thinking was replicated in Experiment 1 with English-speaking 5-year-olds. Experiment 2 indicated that the more active component of vitalism for these children is a belief in the transfer of energy during biological processes, and Experiment 3 suggested an additional, albeit lesser, role for organ intentionality. A belief in vital energy may serve a causal placeholder function within a naive theory of biology until a more precisely formulated mechanism is known.

  16. Teaching biology with engineering practices (United States)

    Potter, Stephen

    The Next Generation Science Standards (NGSS) expresses a vision of science education that requires students to not only have an understanding of science concepts but be able to investigate the natural world through process of science inquiry or to solve meaningful problems though the practices of engineering design. While incorporating engineering practices into our science curriculum will soon be requirement of the new state standards, there is little research published as to how this should be implemented in a biology classroom. The goal of this study was to measure the effectiveness of incorporating engineering design into a biology curriculum on student understanding of engineering practices and science content knowledge. The results of this study indicate that the integration of engineering design in a biology curriculum has a positive effect on student's science content knowledge as well as their understanding of engineering design principles.

  17. Rotating Biological Contactors (RBC's). Student Manual. Biological Treatment Process Control. (United States)

    Zickefoose, Charles S.

    This student manual provides the textual material for a unit on rotating biological contactors (RBC's). Topic areas considered include: (1) flow patterns of water through RBC installations; (2) basic concepts (shaft and stage); (3) characteristics of biomass; (4) mechanical features (bearings, mechanical drive systems, and air drive systems); (5)…

  18. Agriculture and Biology Teaching. Biology and Human Welfare. (United States)

    Rao, A. N.; Pritchard, Alan J.

    This six-chapter document (part of a series on biology and human welfare) focuses on agriculture and the teaching of this subject area. Major topic areas considered in the first five chapters are: (1) the development of agriculture; (2) agricosystems (considering agriculture as an ecosystem, land utilization and soils, soils and food production,…

  19. Integrating Functional, Developmental and Evolutionary Biology into Biology Curricula (United States)

    Haave, Neil


    A complete understanding of life involves how organisms are able to function in their environment and how they arise. Understanding how organisms arise involves both their evolution and development. Thus to completely comprehend living things, biology must study their function, development and evolution. Previous proposals for standardized…

  20. Integrative Biology: A Capstone Course for an Introductory Biology Core (United States)

    Chaplin, Susan B.; Hartung, Nancy Z.


    A capstone to the biology introductory curriculum was developed with the specific goals of enhancing integration of course content, promoting development of oral presentation skills and critical reading and thinking skills, and introducing ecological principles omitted from the rest of the core. Classes of 12 to 16 students were team taught by…

  1. Biological dosimetry of patients with differenced carcinoma of thyroid treated with Iodine-131; Dosimetria biologica de pacientes con carcinoma diferenciado de tiroides tratados con Iodo-131

    Energy Technology Data Exchange (ETDEWEB)

    Vallerga, M. B.; Rojo, A.M.; Taja, M.R.; Deluca, G.; Di Giorgio, M. [Autoridad Regulatoria Nuclear Av. Del Libertador 8250 (C1429BNP). Buenos Aires (Argentina); Fadel, A. [Hospital General de Agudos Dr. Carlos Durand Av. Diaz Velez 5044. Buenos Aires (Argentina); Cabrejas, M.; Valdivieso, C. [Hospital de Clfnicas Jose de San Martin Av. Cordoba 2351 (CP1120). Buenos Aires (Argentina)]. e-mail:


    aberrations it was considered absorbed dose to whole body. The obtained doses were compared by the different biological methods used. The evaluation by internal dosimetry of the data obtained tracer post-activity allowed to personalize the activity of I-131 to administer, starting from physical-mathematical models that consider the particular biokinetics of each patient (MIRD methodology). The doses estimated by the used biological dosemeters were consistent among them. It was discussed its scopes and limitations to be applied in the validation of the dosimetric estimation based on models, in order to administer a therapeutic dose protecting the patient of the adverse effects of the internal radiotherapy in organs that are not target of the same one. The acquired experience is considered of utility to give answer in cases of radioiodine incorporation in occupationally exposed personnel. (Author)

  2. Computational optimization and biological evolution. (United States)

    Goryanin, Igor


    Modelling and optimization principles become a key concept in many biological areas, especially in biochemistry. Definitions of objective function, fitness and co-evolution, although they differ between biology and mathematics, are similar in a general sense. Although successful in fitting models to experimental data, and some biochemical predictions, optimization and evolutionary computations should be developed further to make more accurate real-life predictions, and deal not only with one organism in isolation, but also with communities of symbiotic and competing organisms. One of the future goals will be to explain and predict evolution not only for organisms in shake flasks or fermenters, but for real competitive multispecies environments.

  3. Biological Motion Perception in Autism

    Directory of Open Access Journals (Sweden)

    J Cusack


    Full Text Available Typically developing adults can readily recognize human actions, even when conveyed to them via point-like markers placed on the body of the actor (Johansson, 1973. Previous research has suggested that children affected by autism spectrum disorder (ASD are not equally sensitive to this type of visual information (Blake et al, 2003, but it remains unknown why ASD would impact the ability to perceive biological motion. We present evidence which looks at how adolescents and adults with autism are affected by specific factors which are important in biological motion perception, such as (eg, inter-agent synchronicity, upright/inverted, etc.

  4. Biological effectiveness of antiproton annihilation

    CERN Document Server

    Holzscheiter, Michael H.; Bassler, Niels; Beyer, Gerd; De Marco, John J.; Doser, Michael; Ichioka, Toshiyasu; Iwamoto, Keisuke S.; Knudsen, Helge V.; Landua, Rolf; Maggiore, Carl; McBride, William H.; Møller, Søren Pape; Petersen, Jorgen; Smathers, James B.; Skarsgard, Lloyd D.; Solberg, Timothy D.; Uggerhøj, Ulrik I.; Withers, H.Rodney; Vranjes, Sanja; Wong, Michelle; Wouters, Bradly G.


    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in “biological dose” in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

  5. Rhomboids, signalling and cell biology. (United States)

    Freeman, Matthew


    Here, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important message is that the genetic and biochemical perspective on signalling has tended to underplay the importance of cell biology. There is clear evidence that signalling pathways exploit the control of intracellular trafficking, protein quality control and degradation and other cell biological phenomena, as important regulatory opportunities.

  6. The NASA Space Biology Program (United States)

    Halstead, T. W.


    A discussion is presented of the research conducted under the auspices of the NASA Space Biology Program. The objectives of this Program include the determination of how gravity affects and how it has shaped life on earth, the use of gravity as a tool to investigate relevant biological questions, and obtaining an understanding of how near-weightlessness affects both plants and animals in order to enhance the capability to use and explore space. Several areas of current developmental research are discussed and the future focus of the Program is considered.

  7. Biological effects of electromagnetic fields. (United States)

    Macrì, M. A.; Di Luzio, Sr.; Di Luzio, S.


    Nowadays, concerns about hazards from electromagnetic fields represent an alarming source for human lives in technologically developed countries. We are surrounded by electromagnetic fields everywhere we spend our working hours, rest or recreational activities. The aim of this review is to summarize the biological effects due to these fields arising from power and transmission lines, electrical cable splices, electronic devices inside our homes and work-places, distribution networks and associated devices such as cellular telephones and wireless communication tower, etc. Special care has been reserved to study the biological effects of electromagnetic fields on cell lines of the mammalian immune system about which our research group has been working for several years.

  8. Systems biology approach to bioremediation

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, Romy; Wu, Cindy H.; Hazen, Terry C.


    Bioremediation has historically been approached as a ‘black box’ in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Finally, understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ‘black box’.

  9. [Medical applications of systems biology]. (United States)

    Demongeot, Jacques


    We illustrate in this review some applications of systems biology in the medical and biological areas. After a brief summary of time scales experienced by medical -observations and of the general scheme of dynamic systems, we describe how some techniques underlying the complex systems theory can be applied to model medical issues in immunology, medical genetics, developmental morphogenesis, biochemistry, epidemiology, telemedecine and multiple platforms of expertise. In concluding, we will discuss the issue of "clinomics" coupling clinical and -omics data in a unique patient-specific file.

  10. Mitochondria in biology and medicine

    DEFF Research Database (Denmark)

    Madsen, Claus Desler; Rasmussen, Lene Juel


    pathologies (Luft, 1994). Since 1959, the understanding of mitochondrial cytopathies has evolved immensely and mitochondrial cytopathies are now known to be the largest group of metabolic diseases and to be resulting in a wide variety of pathologies. "Mitochondria in Biology and Medicine" was the title...... of the first annual conference of Society of Mitochondrial Research and Medicine - India. The conference was organized by A. S. Sreedhar, Keshav Singh and Kumarasamy Thangaraj, and was held at The Centre for Cellular and Molecular Biology (CCMB) Hyderabad, India, during 9-10 December 2011. The conference...

  11. Artful interfaces within biological materials

    Directory of Open Access Journals (Sweden)

    John W.C. Dunlop


    Full Text Available Biological materials have a wide range of mechanical properties matching their biological function. This is achieved via complex structural hierarchies, spanning many length scales, arising from the assembly of different sized building blocks during growth. The interfaces between these building blocks can increase resistance to fracture, join materials of different character, make them deform more easily and provide motility. While they represent only a tiny fraction of the overall volume, interfaces are essential for the integrity and function of the overall tissue. Understanding their construction principles, often based on specialized molecular assemblies, may change our current thinking about composite materials.

  12. Biological effectiveness of antiproton annihilation

    DEFF Research Database (Denmark)

    Holzscheiter, M.H.; Agazaryan, N.; Bassler, Niels;


    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct...... measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current...

  13. Synthetic biology and its promises

    Directory of Open Access Journals (Sweden)

    José Manuel De Cózar Escalante


    Full Text Available Synthetic biology is a new science and emerging technology, or rather a technoscience, which converges with others such as nanotechnology, information technology, robotics, artificial intelligence and neuroscience. All have common features that could have highly concerning social and environmental impacts. With its ambitious goals of controlling complexity, redesigning and creating new living entities, synthetic biology perfectly exemplifies the new bioeconomic reality. This requires expanding the focus of the discussion beyond the limited comparative analysis of risks and benefits, to address uncertainties, reassign responsibilities and initiate a thorough social assessment of what is at stake.

  14. System biology of gene regulation. (United States)

    Baitaluk, Michael


    A famous joke story that exhibits the traditionally awkward alliance between theory and experiment and showing the differences between experimental biologists and theoretical modelers is when a University sends a biologist, a mathematician, a physicist, and a computer scientist to a walking trip in an attempt to stimulate interdisciplinary research. During a break, they watch a cow in a field nearby and the leader of the group asks, "I wonder how one could decide on the size of a cow?" Since a cow is a biological object, the biologist responded first: "I have seen many cows in this area and know it is a big cow." The mathematician argued, "The true volume is determined by integrating the mathematical function that describes the outer surface of the cow's body." The physicist suggested: "Let's assume the cow is a sphere...." Finally the computer scientist became nervous and said that he didn't bring his computer because there is no Internet connection up there on the hill. In this humorous but explanatory story suggestions proposed by theorists can be taken to reflect the view of many experimental biologists that computer scientists and theorists are too far removed from biological reality and therefore their theories and approaches are not of much immediate usefulness. Conversely, the statement of the biologist mirrors the view of many traditional theoretical and computational scientists that biological experiments are for the most part simply descriptive, lack rigor, and that much of the resulting biological data are of questionable functional relevance. One of the goals of current biology as a multidisciplinary science is to bring people from different scientific areas together on the same "hill" and teach them to speak the same "language." In fact, of course, when presenting their data, most experimentalist biologists do provide an interpretation and explanation for the results, and many theorists/computer scientists aim to answer (or at least to fully describe

  15. Synthetic Biology in Health and Disease

    NARCIS (Netherlands)

    Passel, van M.W.J.; Lam, C.M.C.; Martins dos Santos, V.A.P.; Suarez Diez, M.


    Synthetic biology draws on the understanding from genetics, biology, chemistry, physics, engineering, and computational sciences to (re-)design and (re-)engineer biological functions. Here we address how synthetic biology can be possibly deployed to promote health and tackle disease. We discuss how

  16. Analyzing the Biology on the System Level


    Tong, Wei


    Although various genome projects have provided us enormous static sequence information, understanding of the sophisticated biology continues to require integrating the computational modeling, system analysis, technology development for experiments, and quantitative experiments all together to analyze the biology architecture on various levels, which is just the origin of systems biology subject. This review discusses the object, its characteristics, and research attentions in systems biology,...

  17. A Brief Introduction to Chinese Biological Abstracts

    Institute of Scientific and Technical Information of China (English)


    Chinese Biological Abstracts (CBA), a state-level indexing and abstracting journal published monthly, is jointly sponsored by the Library of the Chinese Academy of Sciences, the Shanghai Institutes for Biological Sciences as well as the Biological Information Network of the Chinese Academy of Sciences, published and distributed by the Shanghai Institutes for Biological Sciences, and approved by the State Scientific and Technological Commission.

  18. Greek Secondary School Students' Views about Biology (United States)

    Mavrikaki, Evangelia; Koumparou, Helen; Kyriakoudi, Margarita; Papacharalampous, Irene; Trimandili, Maria


    This paper aims to give a picture of Greek students' views about biology and some of the factors that affect them. A questionnaire measuring students' intrinsic motivation to learn biology, individual interest in biology and perceived difficulty of biology, along with information about students' gender, level, parents' occupation and educational…

  19. A Brief Introduction to Chinese Biological Abstracts

    Institute of Scientific and Technical Information of China (English)


    Chinese Biological Abstracts sponsored by the Library, the Shanghai Institutes for Biological Sciences, the Biological Documentation and Information Network, all of the Chinese Academy of Sciences, commenced publication in 1987 and was initiated to provide access to the Chinese information in the field of biology.

  20. [Research progress of cardiac systems biology]. (United States)

    Wang, Juan; Shang, Tong


    Systems Biology is one of the most widely discussed fields among emerging post-genomic disciplines. Medical systems biology is an important component of systems biology. The goals of medical systems biology are gaining a complete understanding of human body in normal and disease states. Driven by the great importance of cardiovascular diseases, cardiac systems biology is improving rapidly. This review provides an overview of major themes in the developing field of cardiac systems biology, including some of the high-throughput experiments and strategies used to integrate the datasets, various types of computational approaches used for developing useful quantitative models, and successful examples, future directions of cardiac systems biology.

  1. Dual Causality and the Autonomy of Biology. (United States)

    Bock, Walter J


    Ernst Mayr's concept of dual causality in biology with the two forms of causes (proximate and ultimate) continues to provide an essential foundation for the philosophy of biology. They are equivalent to functional (=proximate) and evolutionary (=ultimate) causes with both required for full biological explanations. The natural sciences can be classified into nomological, historical nomological and historical dual causality, the last including only biology. Because evolutionary causality is unique to biology and must be included for all complete biological explanations, biology is autonomous from the physical sciences.

  2. Engineering microbes with synthetic biology frameworks. (United States)

    Leonard, Effendi; Nielsen, David; Solomon, Kevin; Prather, Kristala Jones


    Typically, the outcome of biologically engineered unit operations cannot be controlled a priori due to the incorporation of ad hoc design into complex natural systems. To mitigate this problem, synthetic biology presents a systematic approach to standardizing biological components for the purpose of increasing their programmability and robustness when assembled with the aim to achieve novel biological functions. A complex engineered biological system using only standardized biological components is yet to exist. Nevertheless, current attempts to create and to implement modular, standardized biological components pave the way for the future creation of highly predictable artificial biological systems. Although synthetic biology frameworks can be applied to any biological engineering endeavor, this article will focus on providing a brief overview of advances in the field and its recent utilization for the engineering of microbes.

  3. Biology, Violence, and Antisocial Personality. (United States)

    Kandel, Elizabeth

    Aggressive and antisocial behavior have persisted as significant social problems. In response, a voluminous amount of research has been generated in an attempt to discover the causes of such behavior. Previous studies have examined separately the role of perinatal biology in the etiology of violent criminal behavior and the etiology of Anti-Social…


    Rotating biological contactors employ aerobic fixed-film treatment to degrade either organic and/or nitrogenous (ammonia-nitrogen) constituents present in aqueous waste streams. ixed-film systems provide a surface to which the biomass can adhere. Treatment is achieved as the wast...

  5. Biotech drugs : biological therapeutic agents


    Grech, Godfrey; Fenech, Anthony


    The recent years has seen significant growth in a new therapeutic approach to the management of disease. Biological therapeutic agents, constitute a broad category of drugs, usually generated by recombinant techniques from living organisms. These therapies revolutionise the traditional approaches to drug design and development, and regulatory agencies have been swift in developing the necessary structures to ensure their optimal use.

  6. When cell biology meets theory (United States)

    Gonzalez-Gaitan, Marcos


    Cell biologists now have tools and knowledge to generate useful quantitative data. But how can we make sense of these data, and are we measuring the correct parameters? Moreover, how can we test hypotheses quantitatively? To answer these questions, the theory of physics is required and is essential to the future of quantitative cell biology. PMID:26416957

  7. Turing patterns and biological explanation

    DEFF Research Database (Denmark)

    Serban, Maria


    , promoting theory exploration, and acting as constitutive parts of empirically adequate explanations of naturally occurring phenomena, such as biological pattern formation. Focusing on the roles that minimal model explanations play in science motivates the adoption of a broader diachronic view of scientific...

  8. Building multivariate systems biology models

    NARCIS (Netherlands)

    Kirwan, G.M.; Johansson, E.; Kleemann, R.; Verheij, E.R.; Wheelock, A.M.; Goto, S.; Trygg, J.; Wheelock, C.E.


    Systems biology methods using large-scale "omics" data sets face unique challenges: integrating and analyzing near limitless data space, while recognizing and removing systematic variation or noise. Herein we propose a complementary multivariate analysis workflow to both integrate "omics" data from

  9. Anion binding in biological systems (United States)

    Feiters, Martin C.; Meyer-Klaucke, Wolfram; Kostenko, Alexander V.; Soldatov, Alexander V.; Leblanc, Catherine; Michel, Gurvan; Potin, Philippe; Küpper, Frithjof C.; Hollenstein, Kaspar; Locher, Kaspar P.; Bevers, Loes E.; Hagedoorn, Peter-Leon; Hagen, Wilfred R.


    We compare aspects of biological X-ray absorption spectroscopy (XAS) studies of cations and anions, and report on some examples of anion binding in biological systems. Brown algae such as Laminaria digitata (oarweed) are effective accumulators of I from seawater, with tissue concentrations exceeding 50 mM, and the vanadate-containing enzyme haloperoxidase is implicated in halide accumulation. We have studied the chemical state of iodine and its biological role in Laminaria at the I K edge, and bromoperoxidase from Ascophyllum nodosum (knotted wrack) at the Br K edge. Mo is essential for many forms of life; W only for certain archaea, such as Archaeoglobus fulgidus and the hyperthermophilic archaeon Pyrococcus furiosus, and some bacteria. The metals are bound and transported as their oxo-anions, molybdate and tungstate, which are similar in size. The transport protein WtpA from P. furiosus binds tungstate more strongly than molybdate, and is related in sequence to Archaeoglobus fulgidus ModA, of which a crystal structure is known. We have measured A. fulgidus ModA with tungstate at the W L3 (2p3/2) edge, and compared the results with the refined crystal structure. XAS studies of anion binding are feasible even if only weak interactions are present, are biologically relevant, and give new insights in the spectroscopy.

  10. Anion binding in biological systems

    Energy Technology Data Exchange (ETDEWEB)

    Feiters, Martin C [Department of Organic Chemistry, Institute for Molecules and Materials, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (Netherlands); Meyer-Klaucke, Wolfram [EMBL Hamburg Outstation at DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Kostenko, Alexander V; Soldatov, Alexander V [Faculty of Physics, Southern Federal University, Sorge 5, Rostov-na-Donu, 344090 (Russian Federation); Leblanc, Catherine; Michel, Gurvan; Potin, Philippe [Centre National de la Recherche Scientifique and Universite Pierre et Marie Curie Paris-VI, Station Biologique de Roscoff, Place Georges Teissier, BP 74, F-29682 Roscoff cedex, Bretagne (France); Kuepper, Frithjof C [Scottish Association for Marine Science, Dunstaffnage Marine Laboratory, Oban, Argyll PA37 1QA, Scotland (United Kingdom); Hollenstein, Kaspar; Locher, Kaspar P [Institute of Molecular Biology and Biophysics, ETH Zuerich, Schafmattstrasse 20, Zuerich, 8093 (Switzerland); Bevers, Loes E; Hagedoorn, Peter-Leon; Hagen, Wilfred R, E-mail: [Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft (Netherlands)


    We compare aspects of biological X-ray absorption spectroscopy (XAS) studies of cations and anions, and report on some examples of anion binding in biological systems. Brown algae such as Laminaria digitata (oarweed) are effective accumulators of I from seawater, with tissue concentrations exceeding 50 mM, and the vanadate-containing enzyme haloperoxidase is implicated in halide accumulation. We have studied the chemical state of iodine and its biological role in Laminaria at the I K edge, and bromoperoxidase from Ascophyllum nodosum (knotted wrack) at the Br K edge. Mo is essential for many forms of life; W only for certain archaea, such as Archaeoglobus fulgidus and the hyperthermophilic archaeon Pyrococcus furiosus, and some bacteria. The metals are bound and transported as their oxo-anions, molybdate and tungstate, which are similar in size. The transport protein WtpA from P. furiosus binds tungstate more strongly than molybdate, and is related in sequence to Archaeoglobus fulgidus ModA, of which a crystal structure is known. We have measured A. fulgidus ModA with tungstate at the W L{sub 3} (2p{sub 3/2}) edge, and compared the results with the refined crystal structure. XAS studies of anion binding are feasible even if only weak interactions are present, are biologically relevant, and give new insights in the spectroscopy.

  11. Biological Laboratory, Ann Arbor, Michigan (United States)

    Moffett, James W.


    This laboratory located about 40 miles west of Detroit, near the intersection of highways I-94 and US-23, can be reached by bus, railroad, or via commercial airlines to Detroit Willow Run or Metropolitan airports. Field biological stations are located in Wisconsin at Ashland; in Ohio at Sandusky; and in Michigan at Ludington, Marquette, Millersburg, and Northville.

  12. Biology and pathogenesis of Acanthamoeba


    Siddiqui Ruqaiyyah; Khan Naveed


    Abstract Acanthamoeba is a free-living protist pathogen, capable of causing a blinding keratitis and fatal granulomatous encephalitis. The factors that contribute to Acanthamoeba infections include parasite biology, genetic diversity, environmental spread and host susceptibility, and are highlighted together with potential therapeutic and preventative measures. The use of Acanthamoeba in the study of cellular differentiation mechanisms, motility and phagocytosis, bacterial pathogenesis and ev...

  13. The Physics of Marine Biology. (United States)

    Conn, Kathleen


    Discusses ways in which marine biology can be integrated into the physics classroom. Topics suggested for incorporation include the harmonic motion of ocean waves, ocean currents, the interaction of visible light with ocean water, pressure, light absorption, and sound transfer in water. (MDH)

  14. The synthetic biology open language. (United States)

    Myers, Chris; Clancy, Kevin; Misirli, Goksel; Oberortner, Ernst; Pocock, Matthew; Quinn, Jacqueline; Roehner, Nicholas; Sauro, Herbert M


    The design and construction of engineered organisms is an emerging new discipline called synthetic biology and holds considerable promise as a new technological platform. The design of biologically engineered systems is however nontrivial, requiring contributions from a wide array of disciplines. One particular issue that confronts synthetic biologists is the ability to unambiguously describe novel designs such that they can be reengineered by a third-party. For this reason, the synthetic biology open language (SBOL) was developed as a community wide standard for formally representing biological designs. A design created by one engineering team can be transmitted electronically to another who can then use this design to reproduce the experimental results. The development and the community of the SBOL standard started in 2008 and has since grown in use with now over 80 participants, including international, academic, and industrial interests. SBOL has stimulated the development of repositories and software tools to help synthetic biologists in their design efforts. This chapter summarizes the latest developments and future of the SBOL standard and its supporting infrastructure.

  15. Cardiovascular toxicities of biological therapies

    DEFF Research Database (Denmark)

    Ryberg, Marianne


    The development of biological therapy is based on growing knowledge regarding the molecular changes required in cells for the development and progression of cancer to occur. Molecular targeted therapy is designed to inhibit the major molecular pathways identified as essential for a specific...

  16. Expanding the biological periodic table. (United States)

    Seravalli, Javier; Ragsdale, Stephen W


    Metal ions play an indispensable role in biology, enabling enzymes to perform their functions and lending support to the structures of numerous macromolecules. Despite their prevalence and importance, the metalloproteome is still relatively unexplored. Cvetkovic et al. (2010) now describe an approach to identify metalloproteins on a genome-wide scale.

  17. Biology, Philosophy, and Scientific Method. (United States)

    Hill, L.


    The limits of falsification are discussed and the historically based models of science described by Lakatos and Kuhn are shown to offer greater insights into the practice of science. The theory of natural selection is used to relate biology to philosophy and scientific method. (Author/JN)

  18. Biological warfare, bioterrorism, and biocrime. (United States)

    Jansen, H J; Breeveld, F J; Stijnis, C; Grobusch, M P


    Biological weapons achieve their intended target effects through the infectivity of disease-causing infectious agents. The ability to use biological agents in warfare is prohibited by the Biological and Toxin Weapon Convention. Bioterrorism is defined as the deliberate release of viruses, bacteria or other agents used to cause illness or death in people, but also in animals or plants. It is aimed at creating casualties, terror, societal disruption, or economic loss, inspired by ideological, religious or political beliefs. The success of bioterroristic attempts is defined by the measure of societal disruption and panic, and not necessarily by the sheer number of casualties. Thus, making only a few individuals ill by the use of crude methods may be sufficient, as long as it creates the impact that is aimed for. The assessment of bioterrorism threats and motives have been described before. Biocrime implies the use of a biological agent to kill or make ill a single individual or small group of individuals, motivated by revenge or the desire for monetary gain by extortion, rather than by political, ideological, religious or other beliefs. The likelihood of a successful bioterrorist attack is not very large, given the technical difficulties and constraints. However, even if the number of casualties is likely to be limited, the impact of a bioterrorist attack can still be high. Measures aimed at enhancing diagnostic and therapeutic capabilities and capacities alongside training and education will improve the ability of society to combat 'regular' infectious diseases outbreaks, as well as mitigating the effects of bioterrorist attacks.

  19. Testing of Biologically Inhibiting Surface

    DEFF Research Database (Denmark)

    Bill Madsen, Thomas; Larsen, Erup


    The main purpose of this course is to examine a newly developed biologically inhibiting material with regards to galvanic corrosion and electrochemical properties. More in detail, the concern was how the material would react when exposed to cleaning agents, here under CIP cleaning (Cleaning...

  20. Systems biology of industrial microorganisms. (United States)

    Papini, Marta; Salazar, Margarita; Nielsen, Jens


    The field of industrial biotechnology is expanding rapidly as the chemical industry is looking towards more sustainable production of chemicals that can be used as fuels or building blocks for production of solvents and materials. In connection with the development of sustainable bioprocesses, it is a major challenge to design and develop efficient cell factories that can ensure cost efficient conversion of the raw material into the chemical of interest. This is achieved through metabolic engineering, where the metabolism of the cell factory is engineered such that there is an efficient conversion of sugars, the typical raw materials in the fermentation industry, into the desired product. However, engineering of cellular metabolism is often challenging due to the complex regulation that has evolved in connection with adaptation of the different microorganisms to their ecological niches. In order to map these regulatory structures and further de-regulate them, as well as identify ingenious metabolic engineering strategies that full-fill mass balance constraints, tools from systems biology can be applied. This involves both high-throughput analysis tools like transcriptome, proteome and metabolome analysis, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies. It is in fact expected that systems biology may substantially improve the process of cell factory development, and we therefore propose the term Industrial Systems Biology for how systems biology will enhance the development of industrial biotechnology for sustainable chemical production.

  1. Is evolutionary biology strategic science? (United States)

    Meagher, Thomas R


    There is a profound need for the scientific community to be better aware of the policy context in which it operates. To address this need, Evolution has established a new Outlook feature section to include papers that explore the interface between society and evolutionary biology. This first paper in the series considers the strategic relevance of evolutionary biology. Support for scientific research in general is based on governmental or institutional expenditure that is an investment, and such investment is based on strategies designed to achieve particular outcomes, such as advance in particular areas of basic science or application. The scientific community can engage in the development of scientific strategies on a variety of levels, including workshops to explicitly develop research priorities and targeted funding initiatives to help define emerging scientific areas. Better understanding and communication of the scientific achievements of evolutionary biology, emphasizing immediate and potential societal relevance, are effective counters to challenges presented by the creationist agenda. Future papers in the Outlook feature section should assist the evolutionary biology community in achieving a better collective understanding of the societal relevance of their field.

  2. Biological and Chemical Information Technologies

    DEFF Research Database (Denmark)

    Amos, Martyn; Dittrich, Peter; McCaskill, John;


    Biological and chemical information technologies (bio/chem IT) have the potential to reshape the scientific and technological landscape. In this paper we briefly review the main challenges and opportunities in the field, before presenting several case studies based on ongoing FP7 research projects....

  3. Synthetic Biological Engineering of Photosynthesis (United States)


    photosynthesis into artificial metabolic pathways. During the course of the granting period, we also made significant progress on understanding the...compartmentalization of carbon fixation and flux in relationship to photosynthesis and obtained 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND SUBTITLE...2014 Approved for Public Release; Distribution Unlimited Final Report: Synthetic Biological Engineering of Photosynthesis The views, opinions and/or

  4. Education science and biological anthropology. (United States)

    Krebs, Uwe


    This contribution states deficits and makes proposals in order to overcome them. First there is the question as to why the Biological Anthropology--despite all its diversifications--hardly ever deals with educational aspects of its subject. Second it is the question as to why Educational Science neglects or even ignores data of Biological Anthropology which are recognizably important for its subject. It is postulated that the stated deficits are caused by several adverse influences such as, the individual identity of each of the involved single sciences; aspects of the recent history of the German Anthropology; a lack of conceptual understanding of each other; methodological differences and, last but not least, the structure of the universities. The necessity to remedy this situation was deduced from two groups of facts. First, more recent data of the Biological Anthropology (e.g. brain functions and learning, sex specificity and education) are of substantial relevance for the Educational Science. Second, the epistemological requirements of complex subjects like education need interdisciplinary approaches. Finally, a few suggestions of concrete topics are given which are related to both, Educational Science and Biological Anthropology.

  5. Language as a biological entity

    Institute of Scientific and Technical Information of China (English)



    @@ Nowadays, the metaphor of "languageas abiological entity"claimed by some linguists being used widely has become a hot issue. Language and biological entity indeed share a lot of similarities,specifically,the life cycle of languages and the process of the language evolution and the spread of languages.

  6. Teaching the Ethics of Biology. (United States)

    Johansen, Carol K.; Harris, David E.


    Points out the challenges of educating students about bioethics and the limited training of many biologists on ethics. Discusses the basic principles of ethics and ethical decision making as applied to biology. Explains the models of ethical decision making that are often difficult for students to determine where to begin analyzing. (Contains 28…

  7. Systems biology in molecular psychiatry. (United States)

    Gebicke-Haerter, P J


    The last ten to fifteen years have seen a remarkable shift of research strategies from hypothesis-driven, reductionistic to data driven, hypothesis-free approaches. This tendency has become evident after completion of the sequencing of the human genome, when publications under the label systems biology have been skyrocketing. This shift marks a gradual revision of scientific understanding of biological systems. Whilst the former has been component-oriented, precluding elements that do not belong to the hypothesis, the latter try to extract information from the whole system in the first place. Only with this information at hand, data driven strategies develop hypotheses. Data driven strategies unearth the immense complexity of biological systems and, hence, necessitate computer-aided support. Mathematical tools derived from chaos theory appear to be applicable in biological systems, but require significant improvements. The combination of high throughput data collection with in silico modelling of molecular or higher order systems can markedly extend our understanding of onset and progression of diseases. Undoubtedly, systems thinking in brain research is the greatest challenge for the years to come.

  8. Biologic Influences on Exercise Adherence. (United States)

    Dishman, Rod K.


    Diagnostic profiles of 362 male participants in an exercise program were analyzed to determine the biological variables between exercise adherence and symptoms of coronary disease. Findings indicated that individuals with lower metabolic capacity tended to adhere longer, to be less fit, were leaner, and began with more symptoms related to coronary…

  9. Biological physics and synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Filhol, J.M.; Chavanne, J. [European Synchrotron Radiation Facility, 38 - Grenoble (France); Weckert, E. [Hasylab at Desy, Hamburg (Germany)] [and others


    This conference deals with the applications of synchrotron radiation to current problems in biology and medicine. Seven sessions take stock on the subject: sources and detectors; inelastic scattering and dynamics; muscle diffraction; reaction mechanisms; macromolecular assemblies; medical applications; imaging and spectroscopy. The document presents the papers abstracts. (A.L.B.)

  10. Systems Biology of Industrial Microorganisms (United States)

    Papini, Marta; Salazar, Margarita; Nielsen, Jens

    The field of industrial biotechnology is expanding rapidly as the chemical industry is looking towards more sustainable production of chemicals that can be used as fuels or building blocks for production of solvents and materials. In connection with the development of sustainable bioprocesses, it is a major challenge to design and develop efficient cell factories that can ensure cost efficient conversion of the raw material into the chemical of interest. This is achieved through metabolic engineering, where the metabolism of the cell factory is engineered such that there is an efficient conversion of sugars, the typical raw materials in the fermentation industry, into the desired product. However, engineering of cellular metabolism is often challenging due to the complex regulation that has evolved in connection with adaptation of the different microorganisms to their ecological niches. In order to map these regulatory structures and further de-regulate them, as well as identify ingenious metabolic engineering strategies that full-fill mass balance constraints, tools from systems biology can be applied. This involves both high-throughput analysis tools like transcriptome, proteome and metabolome analysis, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies. It is in fact expected that systems biology may substantially improve the process of cell factory development, and we therefore propose the term Industrial Systems Biology for how systems biology will enhance the development of industrial biotechnology for sustainable chemical production.

  11. When cell biology meets theory. (United States)

    Gonzalez-Gaitan, Marcos; Roux, Aurélien


    Cell biologists now have tools and knowledge to generate useful quantitative data. But how can we make sense of these data, and are we measuring the correct parameters? Moreover, how can we test hypotheses quantitatively? To answer these questions, the theory of physics is required and is essential to the future of quantitative cell biology.

  12. Herbivory, Predation, and Biological Control. (United States)

    Murphy, Terence M.; And Others


    Authors describe a set of controlled ecosystems that can be used to demonstrate the effects of herbivory on the health and growth of a plant population and of predation on the growth of a primary consumer population. The system also shows the effectiveness of biological pest control measures in a dramatic way. The construction of the ecosystems is…

  13. [Biological mutualism, concepts and models]. (United States)

    Perru, Olivier


    Mutualism is a biological association for a mutual benefit between two different species. In this paper, firstly, we examine the history and signification of mutualism in relation to symbiosis. Then, we consider the link between concepts and models of mutualism. Models of mutualism depend on different concepts we use: If mutualism is situated at populations' level, it will be expressed by Lotka-Volterra models, concerning exclusively populations' size. If mutualism is considered as a resources' exchange or a biological market increasing the fitness of these organisms, it will be described at an individual level by a cost-benefit model. Our analysis will be limited to the history and epistemology of Lotka-Volterra models and we hypothesize that these models are adapted at first to translate dynamic evolutions of mutualism. They render stability or variations of size and assume that there are clear distinctions and a state of equilibrium between populations of different species. Italian mathematician Vito Volterra demonstrated that biological associations consist in a constant relation between some species. In 1931 and 1935, Volterra described the general form of antagonistic or mutualistic biological associations by the same differential equations. We recognize that these equations have been more used to model competition or prey-predator interactions, but a simple sign change allows describing mutualism. The epistemological problem is the following: Volterra's equations help us to conceptualize a global phenomenon. However, mutualistic interactions may have stronger effects away from equilibrium and these effects may be better understood at individual level. We conclude that, between 1985 and 2000, some researchers carried on working and converting Lotka-Volterra models but this description appeared as insufficient. So, other researchers adopted an economical viewpoint, considering mutualism as a biological market.

  14. Communication theory and multicellular biology. (United States)

    Mian, I S; Rose, C


    In this Perspective, we propose that communication theory--a field of mathematics concerned with the problems of signal transmission, reception and processing--provides a new quantitative lens for investigating multicellular biology, ancient and modern. What underpins the cohesive organisation and collective behaviour of multicellular ecosystems such as microbial colonies and communities (microbiomes) and multicellular organisms such as plants and animals, whether built of simple tissue layers (sponges) or of complex differentiated cells arranged in tissues and organs (members of the 35 or so phyla of the subkingdom Metazoa)? How do mammalian tissues and organs develop, maintain their architecture, become subverted in disease, and decline with age? How did single-celled organisms coalesce to produce many-celled forms that evolved and diversified into the varied multicellular organisms in existence today? Some answers can be found in the blueprints or recipes encoded in (epi)genomes, yet others lie in the generic physical properties of biological matter such as the ability of cell aggregates to attain a certain complexity in size, shape, and pattern. We suggest that Lasswell's maxim "Who says what to whom in what channel with what effect" provides a foundation for understanding not only the emergence and evolution of multicellularity, but also the assembly and sculpting of multicellular ecosystems and many-celled structures, whether of natural or human-engineered origin. We explore how the abstraction of communication theory as an organising principle for multicellular biology could be realised. We highlight the inherent ability of communication theory to be blind to molecular and/or genetic mechanisms. We describe selected applications that analyse the physics of communication and use energy efficiency as a central tenet. Whilst communication theory has and could contribute to understanding a myriad of problems in biology, investigations of multicellular biology

  15. Space Biology in Russia Today (United States)

    Grigoriev, Anatoly; Sychev, Vladimir; Ilyin, Eugene

    At present space biology research in Russia is making significant progress in several areas of high priority. Gravitational biology. In April-May 2013, a successful 30-day flight of the biological satellite (biosatellite) Bion-M1 was conducted, which carried rodents (mice and gerbils), geckos, fish, mollusks, crustaceans, microorganisms, insects, lower and higher plants, seeds, etc. The investigations were performed by Russian scientists as well as by researchers from NASA, CNES, DLR and South Korea. Foton-M4 carrying various biological specimens is scheduled to launch in 2014. Work has begun to develop science research programs to be implemented onboard Bion-M2 and Bion-M3 as well as on high apogee recoverable spacecraft. Study of the effects of microgravity on the growth and development of higher plants cultivated over several generations on the International Space Station (ISS) has been recently completed. Space radiobiology. Regular experiments aimed at investigating the effects of high-energy galactic cosmic rays on the animal central nervous system and behavior are being carried out using the Particle Accelerator in the town of Dubna. Biological (environmental) life support systems. In recent years, experiments have been performed on the ISS to upgrade technologies of plant cultivation in microgravity. Advanced greenhouse mockups have been built and are currentlyundergoing bioengineering tests. Technologies of waste utilization in space are being developed. Astrobiology experiments in orbital missions. In 2010, the Biorisk experiment on bacterial and fungal spores, seeds and dormant forms of organisms was completed. The payload containing the specimens was installed on the exterior wall of the ISS and was exposed to outer space for 31 months. In addition, Bion-M1 also carried seeds, bacterial spores and microbes that were exposed to outer space effects. The survival rate of bacterial spores incorporated into man-made meteorites, that were attached to the

  16. Network biology methods integrating biological data for translational science. (United States)

    Bebek, Gurkan; Koyutürk, Mehmet; Price, Nathan D; Chance, Mark R


    The explosion of biomedical data, both on the genomic and proteomic side as well as clinical data, will require complex integration and analysis to provide new molecular variables to better understand the molecular basis of phenotype. Currently, much data exist in silos and is not analyzed in frameworks where all data are brought to bear in the development of biomarkers and novel functional targets. This is beginning to change. Network biology approaches, which emphasize the interactions between genes, proteins and metabolites provide a framework for data integration such that genome, proteome, metabolome and other -omics data can be jointly analyzed to understand and predict disease phenotypes. In this review, recent advances in network biology approaches and results are identified. A common theme is the potential for network analysis to provide multiplexed and functionally connected biomarkers for analyzing the molecular basis of disease, thus changing our approaches to analyzing and modeling genome- and proteome-wide data.

  17. Biology and Mechanics of Blood Flows Part I: Biology

    CERN Document Server

    Thiriet, Marc


    Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part I of this two-volume sequence, Biology, addresses the nanoscopic and microscopic scales. The nanoscale corresponds to the scale of biochemical reaction cascades involved in cell adaptation to mechanical stresses among other stimuli. The microscale is the scale of stress-induced tissue remodeling associated with acute or chronic loadings. The cardiovascular system, like any physiological system, has a complicated three-dimensional structure and composition. Its time dependent behavior is regulated, and this complex system has many components. In this authoritative work, the author provides a survey of relevant cell components and processes, with detailed coverage of the electrical and mechanical behaviors of vascular cells, tissues, and organs. Because the behaviors of vascular cells and tissues are tightly coupl...

  18. 78 FR 43817 - Distribution of Reference Biological Standards and Biological Preparations (United States)


    ... HUMAN SERVICES 42 CFR Part 7 RIN 0920-AA53 Distribution of Reference Biological Standards and Biological... sections of its regulations titled ``Distribution of Reference Biological Standards and Biological... section states that HHS/CDC may prepare any biological product described under section 351 of the...

  19. Systems biology: the reincarnation of systems theory applied in biology? (United States)

    Wolkenhauer, O


    With the availability of quantitative data on the transcriptome and proteome level, there is an increasing interest in formal mathematical models of gene expression and regulation. International conferences, research institutes and research groups concerned with systems biology have appeared in recent years and systems theory, the study of organisation and behaviour per se, is indeed a natural conceptual framework for such a task. This is, however, not the first time that systems theory has been applied in modelling cellular processes. Notably in the 1960s systems theory and biology enjoyed considerable interest among eminent scientists, mathematicians and engineers. Why did these early attempts vanish from research agendas? Here we shall review the domain of systems theory, its application to biology and the lessons that can be learned from the work of Robert Rosen. Rosen emerged from the early developments in the 1960s as a main critic but also developed a new alternative perspective to living systems, a concept that deserves a fresh look in the post-genome era of bioinformatics.

  20. Knowledge-making distinctions in synthetic biology. (United States)

    O'Malley, Maureen A; Powell, Alexander; Davies, Jonathan F; Calvert, Jane


    Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems.

  1. Stochastic processes in cell biology

    CERN Document Server

    Bressloff, Paul C


    This book develops the theory of continuous and discrete stochastic processes within the context of cell biology.  A wide range of biological topics are covered including normal and anomalous diffusion in complex cellular environments, stochastic ion channels and excitable systems, stochastic calcium signaling, molecular motors, intracellular transport, signal transduction, bacterial chemotaxis, robustness in gene networks, genetic switches and oscillators, cell polarization, polymerization, cellular length control, and branching processes. The book also provides a pedagogical introduction to the theory of stochastic process – Fokker Planck equations, stochastic differential equations, master equations and jump Markov processes, diffusion approximations and the system size expansion, first passage time problems, stochastic hybrid systems, reaction-diffusion equations, exclusion processes, WKB methods, martingales and branching processes, stochastic calculus, and numerical methods.   This text is primarily...

  2. Dissipative Structures and Biological Evolution (United States)

    Brändas, E. J.

    This contribution celebrates Prof. Manuel G. Velarde's exceptional accomplishments in the science of Complex Systems and Non-Linear Dynamics in connection with his seventieth anniversary and subsequent retirement from the Instituto Pluridisciplinar de la Universidad Complutense de Madrid (UCM). In this commemoration I will discuss my provisional yet unique association with Manuel over the years. Although viewing scientific problems from differing ends of the micro-macro spectrum I believe our relationship has been mutually beneficial. In this account I will, in a few words, describe recent developments in our program to attack complicated issues on the borderline between physics and biology. Concrete overlapping interests incorporate problems related to strongly correlated systems like superconductivity as well as currently disputed issues pertaining to biological concepts and the unity of physical theory. In summary we will give examples of such wide-ranging proposals comprising potential avenues providing feasible platforms for the future.

  3. Nonlinear dynamics in biological systems

    CERN Document Server

    Carballido-Landeira, Jorge


    This book presents recent research results relating to applications of nonlinear dynamics, focusing specifically on four topics of wide interest: heart dynamics, DNA/RNA, cell mobility, and proteins. The book derives from the First BCAM Workshop on Nonlinear Dynamics in Biological Systems, held in June 2014 at the Basque Center of Applied Mathematics (BCAM). At this international meeting, researchers from different but complementary backgrounds, including molecular dynamics, physical chemistry, bio-informatics and biophysics, presented their most recent results and discussed the future direction of their studies using theoretical, mathematical modeling and experimental approaches. Such was the level of interest stimulated that the decision was taken to produce this publication, with the organizers of the event acting as editors. All of the contributing authors are researchers working on diverse biological problems that can be approached using nonlinear dynamics. The book will appeal especially to applied math...

  4. The hidden simplicity of biology (United States)

    Davies, Paul C. W.; Imari Walker, Sara


    Life is so remarkable, and so unlike any other physical system, that it is tempting to attribute special factors to it. Physics is founded on the assumption that universal laws and principles underlie all natural phenomena, but is it far from clear that there are ‘laws of life’ with serious descriptive or predictive power analogous to the laws of physics. Nor is there (yet) a ‘theoretical biology’ in the same sense as theoretical physics. Part of the obstacle in developing a universal theory of biological organization concerns the daunting complexity of living organisms. However, many attempts have been made to glimpse simplicity lurking within this complexity, and to capture this simplicity mathematically. In this paper we review a promising new line of inquiry to bring coherence and order to the realm of biology by focusing on ‘information’ as a unifying concept.

  5. Current perspectives of inhibin biology. (United States)

    Risbridger, G P; Robertson, D M; de Kretser, D M


    Inhibin is generally considered to be a feedback regulator of FSH secretion, but significant progress in the field of inhibin biology over the past four years has widened our perspective of inhibin and its production, regulation and action. Firstly, inhibin is a member of a larger family of hormones, secondly it is produced by organs other than the gonads, and thirdly its action is not confined to the pituitary gland. In this review we will outline the isolation and characterization of inhibin related peptides and their production by the Sertoli and granulosa cells of the testis and ovary. With this information in mind, more recent studies concerning the measurement, production, regulation and action of inhibin and inhibin-related proteins will be discussed, in an effort to alert the reader to the contemporary and controversial issues concerning inhibin biology.

  6. Biology of Applied Digital Ecosystems

    CERN Document Server

    Briscoe, G; Paperin, G


    A primary motivation for research in digital ecosystems is the desire to exploit the self-organising properties of natural ecosystems. Ecosystems are thought to be robust, scalable architectures that can automatically solve complex, dynamic problems. However, the biological processes that contribute to these properties have not been made explicit in digital ecosystem research. Here, we discuss how biological properties contribute to the self-organising features of natural ecosystems. These properties include populations of evolving agents, a complex dynamic environment, and spatial distributions which generate local interactions. The potential for exploiting these properties in artificial systems is then considered. An example architecture, the Digital Business Ecosystem (DBE), is considered in detail. Simulation results imply that the DBE performs better at large scales than a comparable service-oriented architecture. These results suggest that incorporating ideas from theoretical ecology can contribute to u...

  7. Synthetic biology character and impact

    CERN Document Server

    Pade, Christian; Wigger, Henning; Gleich, Arnim


    Synthetic Biology is already an object of intensive debate. However, to a great extent the discussion to date has been concerned with fundamental ethical, religious and philosophical questions. By contrast, based on an investigation of the field’s scientific and technological character, this book focuses on new functionalities provided by synthetic biology and explores the associated opportunities and risks. Following an introduction to the subject and a discussion of the most central paradigms and methodologies, the book provides an overview of the structure of this field of science and technology. It informs the reader about the current stage of development, as well as topical problems and potential opportunities in important fields of application. But not only the science itself is in focus. In order to investigate its broader impact, ecological as well as ethical implications will be considered, paving the way for a discussion of responsibilities in the context of a field at a transitional crossroads be...

  8. Teaching biology with model organisms (United States)

    Keeley, Dolores A.

    The purpose of this study is to identify and use model organisms that represent each of the kingdoms biologists use to classify organisms, while experiencing the process of science through guided inquiry. The model organisms will be the basis for studying the four high school life science core ideas as identified by the Next Generation Science Standards (NGSS): LS1-From molecules to organisms, LS2-Ecosystems, LS3- Heredity, and LS4- Biological Evolution. NGSS also have identified four categories of science and engineering practices which include developing and using models and planning and carrying out investigations. The living organisms will be utilized to increase student interest and knowledge within the discipline of Biology. Pre-test and posttest analysis utilizing student t-test analysis supported the hypothesis. This study shows increased student learning as a result of using living organisms as models for classification and working in an inquiry-based learning environment.

  9. Molecular Processes in Biological Thermosensation

    Directory of Open Access Journals (Sweden)

    I. Digel


    Full Text Available Since thermal gradients are almost everywhere, thermosensation could represent one of the oldest sensory transduction processes that evolved in organisms. There are many examples of temperature changes affecting the physiology of living cells. Almost all classes of biological macromolecules in a cell (nucleic acids, lipids, proteins can present a target of the temperature-related stimuli. This review discusses some features of different classes of temperature-sensing molecules as well as molecular and biological processes that involve thermosensation. Biochemical, structural, and thermodynamic approaches are applied in the paper to organize the existing knowledge on molecular mechanisms of thermosensation. Special attention is paid to the fact that thermosensitive function cannot be assigned to any particular functional group or spatial structure but is rather of universal nature. For instance, the complex of thermodynamic, structural, and functional features of hemoglobin family proteins suggests their possible accessory role as “molecular thermometers”.

  10. Programming languages for synthetic biology. (United States)

    Umesh, P; Naveen, F; Rao, Chanchala Uma Maheswara; Nair, Achuthsankar S


    In the backdrop of accelerated efforts for creating synthetic organisms, the nature and scope of an ideal programming language for scripting synthetic organism in-silico has been receiving increasing attention. A few programming languages for synthetic biology capable of defining, constructing, networking, editing and delivering genome scale models of cellular processes have been recently attempted. All these represent important points in a spectrum of possibilities. This paper introduces Kera, a state of the art programming language for synthetic biology which is arguably ahead of similar languages or tools such as GEC, Antimony and GenoCAD. Kera is a full-fledged object oriented programming language which is tempered by biopart rule library named Samhita which captures the knowledge regarding the interaction of genome components and catalytic molecules. Prominent feature of the language are demonstrated through a toy example and the road map for the future development of Kera is also presented.

  11. Deep learning for computational biology. (United States)

    Angermueller, Christof; Pärnamaa, Tanel; Parts, Leopold; Stegle, Oliver


    Technological advances in genomics and imaging have led to an explosion of molecular and cellular profiling data from large numbers of samples. This rapid increase in biological data dimension and acquisition rate is challenging conventional analysis strategies. Modern machine learning methods, such as deep learning, promise to leverage very large data sets for finding hidden structure within them, and for making accurate predictions. In this review, we discuss applications of this new breed of analysis approaches in regulatory genomics and cellular imaging. We provide background of what deep learning is, and the settings in which it can be successfully applied to derive biological insights. In addition to presenting specific applications and providing tips for practical use, we also highlight possible pitfalls and limitations to guide computational biologists when and how to make the most use of this new technology.

  12. Osteocyte biology and space flight. (United States)

    Pajevic, Paola Divieti; Spatz, Jordan M; Garr, Jenna; Adamson, Chris; Misener, Lowell


    The last decade has seen an impressive expansion of our understanding of the role of osteocytes in skeletal homeostasis. These amazing cells, deeply embedded into the mineralized matrix, are the key regulators of bone homeostasis and skeletal mechano sensation and transduction. They are the cells that can sense the mechanical forces applied to the bone and then translate these forces into biological responses. They are also ideally positioned to detect and respond to hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts through the production and secretion of molecules such as Sclerostin and RANKL. How osteocytes perceive mechanical forces and translate them into biological responses in still an open question. Novel "in vitro" models as well the opportunity to study these cells under microgravity condition, will allow a closer look at the molecular and cellular mechanisms of mechano transduction. This article highlights novel investigations on osteocytes and discusses their significance in our understanding of skeletal mechano transduction.

  13. Olefin Metathesis for Chemical Biology (United States)

    Binder, Joseph B; Raines, Ronald T


    Summary Chemical biology relies on effective synthetic chemistry for building molecules to probe and modulate biological function. Olefin metathesis in organic solvents is a valuable addition to this armamentarium, and developments during the previous decade are enabling metathesis in aqueous solvents for the manipulation of biomolecules. Functional group-tolerant ruthenium metathesis catalysts modified with charged moieties or hydrophilic polymers are soluble and active in water, enabling ring-opening metathesis polymerization, cross metathesis, and ring-closing metathesis. Alternatively, conventional hydrophobic ruthenium complexes catalyze a similar array of metathesis reactions in mixtures of water and organic solvents. This strategy has enabled cross metathesis on the surface of a protein. Continuing developments in catalyst design and methodology will popularize the bioorthogonal reactivity of metathesis. PMID:18935975

  14. The Biology of Neisseria Adhesins

    Directory of Open Access Journals (Sweden)

    Miao-Chiu Hung


    Full Text Available Members of the genus Neisseria include pathogens causing important human diseases such as meningitis, septicaemia, gonorrhoea and pelvic inflammatory disease syndrome. Neisseriae are found on the exposed epithelia of the upper respiratory tract and the urogenital tract. Colonisation of these exposed epithelia is dependent on a repertoire of diverse bacterial molecules, extending not only from the surface of the bacteria but also found within the outer membrane. During invasive disease, pathogenic Neisseriae also interact with immune effector cells, vascular endothelia and the meninges. Neisseria adhesion involves the interplay of these multiple surface factors and in this review we discuss the structure and function of these important molecules and the nature of the host cell receptors and mechanisms involved in their recognition. We also describe the current status for recently identified Neisseria adhesins. Understanding the biology of Neisseria adhesins has an impact not only on the development of new vaccines but also in revealing fundamental knowledge about human biology.

  15. Ontologies in biological data visualization. (United States)

    Carpendale, Sheelagh; Chen, Min; Evanko, Daniel; Gehlenborg, Nils; Gorg, Carsten; Hunter, Larry; Rowland, Francis; Storey, Margaret-Anne; Strobelt, Hendrik


    In computer science, an ontology is essentially a graph-based knowledge representation in which each node corresponds to a concept and each edge specifies a relation between two concepts. Ontological development in biology can serve as a focus to discuss the challenges and possible research directions for ontologies in visualization. The principle challenges are the dynamic and evolving nature of ontologies, the ever-present issue of scale, the diversity and richness of the relationships in ontologies, and the need to better understand the relationship between ontologies and the data analysis tasks scientists wish to support. Research directions include visualizing ontologies; visualizing semantically or ontologically annotated texts, documents, and corpora; automated generation of visualizations using ontologies; and visualizing ontological context to support search. Although this discussion uses issues of ontologies in biological data visualization as a springboard, these topics are of general relevance to visualization.

  16. Biological signals classification and analysis

    CERN Document Server

    Kiasaleh, Kamran


    This authored monograph presents key aspects of signal processing analysis in the biomedical arena. Unlike wireless communication systems, biological entities produce signals with underlying nonlinear, chaotic nature that elude classification using the standard signal processing techniques, which have been developed over the past several decades for dealing primarily with standard communication systems. This book separates what is random from that which appears to be random, and yet is truly deterministic with random appearance. At its core, this work gives the reader a perspective on biomedical signals and the means to classify and process such signals. In particular, a review of random processes along with means to assess the behavior of random signals is also provided. The book also includes a general discussion of biological signals in order to demonstrate the inefficacy of the well-known techniques to correctly extract meaningful information from such signals. Finally, a thorough discussion of recently ...

  17. Carbon nanomaterials in biological systems

    Energy Technology Data Exchange (ETDEWEB)

    Pu Chun Ke [Laboratory of Single-Molecule Biophysics and Polymer Physics, Department of Physics and Astronomy, Clemson University, Clemson, SC 29634 (United States); Qiao Rui [Department of Mechanical Engineering, Clemson University, Clemson, SC 29634 (United States)


    This paper intends to reflect, from the biophysical viewpoint, our current understanding on interfacing nanomaterials, such as carbon nanotubes and fullerenes, with biological systems. Strategies for improving the solubility, and therefore, the bioavailability of nanomaterials in aqueous solutions are summarized. In particular, the underlining mechanisms of attaching biomacromolecules (DNA, RNA, proteins) and lysophospholipids onto carbon nanotubes and gallic acids onto fullerenes are analyzed. The diffusion and the cellular delivery of RNA-coated carbon nanotubes are characterized using fluorescence microscopy. The translocation of fullerenes across cell membranes is simulated using molecular dynamics to offer new insight into the complex issue of nanotoxicity. To assess the fate of nanomaterials in the environment, the biomodification of lipid-coated carbon nanotubes by the aquatic organism Daphnia magna is discussed. The aim of this paper is to illuminate the need for adopting multidisciplinary approaches in the field study of nanomaterials in biological systems and in the environment. (topical review)

  18. Structural Biology: Practical NMR Applications

    CERN Document Server

    Teng, Quincy


    This textbook begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

  19. Biomaterial science meets computational biology. (United States)

    Hutmacher, Dietmar W; Little, J Paige; Pettet, Graeme J; Loessner, Daniela


    There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell-cell and cell-niche interactions.

  20. The semantics of biological forms. (United States)

    Albertazzi, Liliana; Canal, Luisa; Dadam, James; Micciolo, Rocco


    This study analyses how certain qualitative perceptual appearances of biological forms are correlated with expressions of natural language. Making use of the Osgood semantic differential, we presented the subjects with 32 drawings of biological forms and a list of 10 pairs of connotative adjectives to be put in correlations with them merely by subjective judgments. The principal components analysis made it possible to group the semantics of forms according to two distinct axes of variability: harmony and dynamicity. Specifically, the nonspiculed, nonholed, and flat forms were perceived as harmonic and static; the rounded ones were harmonic and dynamic. The elongated forms were somewhat disharmonious and somewhat static. The results suggest the existence in the general population of a correspondence between perceptual and semantic processes, and of a nonsymbolic relation between visual forms and their adjectival expressions in natural language.

  1. Light in elementary biological reactions (United States)

    Sundström, Villy


    Light plays an important role in biology. In this review we discuss several processes and systems where light triggers a biological response, i.e. photosynthesis, vision, photoreceptors. For these functions Nature has chosen simple elementary chemical reactions, which occur in highly specialized and organized structures. The high efficiency and specificity of these reactions make them interesting for applications in light energy conversion and opto-electronics. In order to emphasize the synergism in studies of natural and synthetic systems we will discuss a few of each kind, with similar functions. In all cases light triggers a rapid sequence of events, which makes ultrafast spectroscopy an ideal tool to disentangle reaction mechanisms and dynamics.

  2. Stable States of Biological Organisms

    CERN Document Server

    Yukalov, V I; Yukalova, E P; Henry, J -Y; Cobb, J P


    A novel model of biological organisms is advanced, treating an organism as a self-consistent system subject to a pathogen flux. The principal novelty of the model is that it describes not some parts, but a biological organism as a whole. The organism is modeled by a five-dimensional dynamical system. The organism homeostasis is described by the evolution equations for five interacting components: healthy cells, ill cells, innate immune cells, specific immune cells, and pathogens. The stability analysis demonstrates that, in a wide domain of the parameter space, the system exhibits robust structural stability. There always exist four stable stationary solutions characterizing four qualitatively differing states of the organism: alive state, boundary state, critical state, and dead state.

  3. Insights into circular RNA biology

    DEFF Research Database (Denmark)

    Ebbesen, Karoline K; Hansen, Thomas B; Kjems, Jørgen


    Circular RNAs (circRNAs) are a novel class of non-coding RNA characterized by a covalently closed-loop structure generated through a special type of alternative splicing termed backsplicing. CircRNAs are emerging as a heterogeneous class of molecules involved in modulating gene expression by regu...... and lastly, an outlook with a focus on unanswered questions regarding circRNA biology will be included....

  4. Biology-Inspired Autonomous Control (United States)


    of, and perhaps will not be tolerated in, manmade critical systems. Although this paper does not directly address questions of ethics associated...political, ethical , and moral issues associated with the use of autonomous systems in warfare will be debated long after the technology hurdles to...accessible discussion on the interplay of biochemistry, genetics and embryology in animal evolution; Wagner, 2005 describes biological concepts of

  5. Nonlinear analysis of biological sequences

    Energy Technology Data Exchange (ETDEWEB)

    Torney, D.C.; Bruno, W.; Detours, V. [and others


    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The main objectives of this project involved deriving new capabilities for analyzing biological sequences. The authors focused on tabulating the statistical properties exhibited by Human coding DNA sequences and on techniques of inferring the phylogenetic relationships among protein sequences related by descent.

  6. Biological rhythms and vector insects

    Directory of Open Access Journals (Sweden)

    Mirian David Marques


    Full Text Available The adjustment of all species, animals and plants, to the Earth’s cyclic environments is ensured by their temporal organisation. The relationships between parasites, vectors and hosts rely greatly upon the synchronisation of their biological rhythms, especially circadian rhythms. In this short note, parasitic infections by Protozoa and by microfilariae have been chosen as examples of the dependence of successful transmission mechanisms on temporal components.

  7. Correlation Effects in Biological Networks

    Directory of Open Access Journals (Sweden)

    A.A. Bagdasaryan


    Full Text Available Review of the complex network theory is presented and classification of such networks in accordance with the main statistical characteristics is considered. For the adjacency matrix of a real neural network the shortest distances for each pair of nodes as well as the node degree distribution and cluster coefficients are calculated. Comparison of the main statistical parameters with the random network is performed, and based on this, the conclusions about the correlation phenomena in biological system are made.

  8. Allostatic load and biological anthropology. (United States)

    Edes, Ashley N; Crews, Douglas E


    Multiple stressors affect developing and adult organisms, thereby partly structuring their phenotypes. Determining how stressors influence health, well-being, and longevity in human and nonhuman primate populations are major foci within biological anthropology. Although much effort has been devoted to examining responses to multiple environmental and sociocultural stressors, no holistic metric to measure stress-related physiological dysfunction has been widely applied within biological anthropology. Researchers from disciplines outside anthropology are using allostatic load indices (ALIs) to estimate such dysregulation and examine life-long outcomes of stressor exposures, including morbidity and mortality. Following allostasis theory, allostatic load represents accumulated physiological and somatic damage secondary to stressors and senescent processes experienced over the lifespan. ALIs estimate this wear-and-tear using a composite of biomarkers representing neuroendocrine, cardiovascular, metabolic, and immune systems. Across samples, ALIs are associated significantly with multiple individual characteristics (e.g., age, sex, education, DNA variation) of interest within biological anthropology. They also predict future outcomes, including aspects of life history variation (e.g., survival, lifespan), mental and physical health, morbidity and mortality, and likely health disparities between groups, by stressor exposures, ethnicity, occupations, and degree of departure from local indigenous life ways and integration into external and commodified ones. ALIs also may be applied to similar stress-related research areas among nonhuman primates. Given the reports from multiple research endeavors, here we propose ALIs may be useful for assessing stressors, stress responses, and stress-related dysfunction, current and long-term cognitive function, health and well-being, and risk of early mortality across many research programs within biological anthropology.

  9. Africa and Precambrian biological evolution


    Knoll, A.H


    African sedimentary rocks and their contained fossils have played a fundamental role in the unravelling of Precambrian biological history. Various lines of evidence including stromatolites, filamentous and coccoidal microfossils, stable isotope ratios, organic carbon distribution, and oxide facies iron formation suggest that a complex prokaryotic ecosystem fueled by photosynthesis, and perhaps including aerobic photoautotrophs, existed as early as 3 500 m.y. ago. The primary sources of data o...

  10. Biological couplings: Function, characteristics and implementation mode

    Institute of Scientific and Technical Information of China (English)


    Through rigorous natural selection, biological organisms have evolved exceptional functions highly adaptable to their living environments. Biological organisms can achieve a variety of biological functions efficiently by using the synergic actions of two or more different parts of the body, or the coupling effects of multiple factors, and demonstrate optimal adaptations to the living environment. In this paper, the function, characteristics and types of biological couplings are analyzed, the implementation mechanism and mode of biological coupling functions are revealed from the bionic viewpoint. Finally, the technological prospects of the bionic implementation of biological coupling function are predicted.

  11. Recent progress in histochemistry and cell biology. (United States)

    Hübner, Stefan; Efthymiadis, Athina


    Studies published in Histochemistry and Cell Biology in the year 2011 represent once more a manifest of established and newly sophisticated techniques being exploited to put tissue- and cell type-specific molecules into a functional context. The review is therefore the Histochemistry and Cell Biology's yearly intention to provide interested readers appropriate summaries of investigations touching the areas of tissue biology, developmental biology, the biology of the immune system, stem cell research, the biology of subcellular compartments, in order to put the message of such studies into natural scientific-/human- and also pathological-relevant correlations.

  12. The cell biology of aging (United States)

    DiLoreto, Race; Murphy, Coleen T.


    One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts. We now have evidence that aging is instead at least in part genetically regulated. Many mutations have been discovered to extend lifespan in organisms of all complexities, from yeast to mammals. The study of metazoan model organisms, such as Caenorhabditis elegans, has been instrumental in understanding the role of genetics in the cell biology of aging. Longevity mutants across the spectrum of model organisms demonstrate that rates of aging are regulated through genetic control of cellular processes. The regulation and subsequent breakdown of cellular processes represent a programmatic decision by the cell to either continue or abandon maintenance procedures with age. Our understanding of cell biological processes involved in regulating aging have been particularly informed by longevity mutants and treatments, such as reduced insulin/IGF-1 signaling and dietary restriction, which are critical in determining the distinction between causes of and responses to aging and have revealed a set of downstream targets that participate in a range of cell biological activities. Here we briefly review some of these important cellular processes. PMID:26668170

  13. Imidazole: Having Versatile Biological Activities

    Directory of Open Access Journals (Sweden)

    Amita Verma


    Full Text Available Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of imidazole-containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of imidazole during the past years.

  14. Decavanadate effects in biological systems. (United States)

    Aureliano, Manuel; Gândara, Ricardo M C


    Vanadium biological studies often disregarded the formation of decameric vanadate species known to interact, in vitro, with high-affinity with many proteins such as myosin and sarcoplasmic reticulum calcium pump and also to inhibit these biochemical systems involved in energy transduction. Moreover, very few in vivo animal studies involving vanadium consider the contribution of decavanadate to vanadium biological effects. Recently, it has been shown that an acute exposure to decavanadate but not to other vanadate oligomers induced oxidative stress and a different fate in vanadium intracellular accumulation. Several markers of oxidative stress analyzed on hepatic and cardiac tissue were monitored after in vivo effect of an acute exposure (12, 24 h and 7 days), to a sub-lethal concentration (5 mM; 1 mg/kg) of two vanadium solutions ("metavanadate" and "decavanadate"). It was observed that "decavanadate" promote different effects than other vanadate oligomers in catalase activity, glutathione content, lipid peroxidation, mitochondrial superoxide anion production and vanadium accumulation, whereas both solutions seem to equally depress reactive oxygen species (ROS) production as well as total intracellular reducing power. Vanadium is accumulated in mitochondria in particular when "decavanadate" is administered. These recent findings, that are now summarized, point out the decameric vanadate species contributions to in vivo and in vitro effects induced by vanadium in biological systems.


    Directory of Open Access Journals (Sweden)

    Stolуarova M. A.


    Full Text Available The article describes the innovations in the classification and measurement of biological assets according to IFRS (IAS 41 "Agriculture". The difficulties faced by agricultural producers using standard, set out in article. The classification based on the adopted amendments, according to which the fruit-bearing plants, previously accounted for as biological assets are measured at fair value are included in the category of fixed assets. The structure of biological assets and main means has been studied in trials. Changes made to the IFRS (IAS 41 "Agriculture", make similar national and international accounting rules. In this way, the fruit-bearing plants are carried at cost, taking into account accumulated depreciation. This approach is similar in both accounting systems. The method of accounting of fruit-bearing assets, which after maturation are not significant biotransformation in the value, has been simplifying accounting. According to the fruit-bearing assets, active market was absent; therefore, the estimation of fair value for them is not correct. The model of using fruit-bearing assets is similar to the use of industrial equipment. Historical cost is more appropriate and meets economic substance of the objects. Assessment of performance of fruit-bearing assets and indicators of their use is represented on an example of perennial crops

  16. Dueling biological and social contagions (United States)

    Fu, Feng; Christakis, Nicholas A.; Fowler, James H.


    Numerous models explore how a wide variety of biological and social phenomena spread in social networks. However, these models implicitly assume that the spread of one phenomenon is not affected by the spread of another. Here, we develop a model of “dueling contagions”, with a particular illustration of a situation where one is biological (influenza) and the other is social (flu vaccination). We apply the model to unique time series data collected during the 2009 H1N1 epidemic that includes information about vaccination, flu, and face-to-face social networks. The results show that well-connected individuals are more likely to get vaccinated, as are people who are exposed to friends who get vaccinated or are exposed to friends who get the flu. Our dueling contagion model suggests that other epidemiological models may be dramatically underestimating the R0 of contagions. It also suggests that the rate of vaccination contagion may be even more important than the biological contagion in determining the course of the disease. These results suggest that real world and online platforms that make it easier to see when friends have been vaccinated (personalized vaccination campaigns) and when they get the flu (personalized flu warnings) could have a large impact on reducing the severity of epidemics. They also suggest possible benefits from understanding the coevolution of many kinds of dueling contagions. PMID:28252663

  17. Stochastic simulation in systems biology. (United States)

    Székely, Tamás; Burrage, Kevin


    Natural systems are, almost by definition, heterogeneous: this can be either a boon or an obstacle to be overcome, depending on the situation. Traditionally, when constructing mathematical models of these systems, heterogeneity has typically been ignored, despite its critical role. However, in recent years, stochastic computational methods have become commonplace in science. They are able to appropriately account for heterogeneity; indeed, they are based around the premise that systems inherently contain at least one source of heterogeneity (namely, intrinsic heterogeneity). In this mini-review, we give a brief introduction to theoretical modelling and simulation in systems biology and discuss the three different sources of heterogeneity in natural systems. Our main topic is an overview of stochastic simulation methods in systems biology. There are many different types of stochastic methods. We focus on one group that has become especially popular in systems biology, biochemistry, chemistry and physics. These discrete-state stochastic methods do not follow individuals over time; rather they track only total populations. They also assume that the volume of interest is spatially homogeneous. We give an overview of these methods, with a discussion of the advantages and disadvantages of each, and suggest when each is more appropriate to use. We also include references to software implementations of them, so that beginners can quickly start using stochastic methods for practical problems of interest.

  18. A biologically inspired MANET architecture (United States)

    Kershenbaum, Aaron; Pappas, Vasileios; Lee, Kang-Won; Lio, Pietro; Sadler, Brian; Verma, Dinesh


    Mobile Ad-Hoc Networks (MANETs), that do not rely on pre-existing infrastructure and that can adapt rapidly to changes in their environment, are coming into increasingly wide use in military applications. At the same time, the large computing power and memory available today even for small, mobile devices, allows us to build extremely large, sophisticated and complex networks. Such networks, however, and the software controlling them are potentially vulnerable to catastrophic failures because of their size and complexity. Biological networks have many of these same characteristics and are potentially subject to the same problems. But in successful organisms, these biological networks do in fact function well so that the organism can survive. In this paper, we present a MANET architecture developed based on a feature, called homeostasis, widely observed in biological networks but not ordinarily seen in computer networks. This feature allows the network to switch to an alternate mode of operation under stress or attack and then return to the original mode of operation after the problem has been resolved. We explore the potential benefits such an architecture has, principally in terms of the ability to survive radical changes in its environment using an illustrative example.

  19. Measurement Frontiers in Molecular Biology (United States)

    Laderman, Stephen


    Developments of molecular measurements and manipulations have long enabled forefront research in evolution, genetics, biological development and its dysfunction, and the impact of external factors on the behavior of cells. Measurement remains at the heart of exciting and challenging basic and applied problems in molecular and cell biology. Methods to precisely determine the identity and abundance of particular molecules amongst a complex mixture of similar and dissimilar types require the successful design and integration of multiple steps involving biochemical manipulations, separations, physical probing, and data processing. Accordingly, today's most powerful methods for characterizing life at the molecular level depend on coordinated advances in applied physics, biochemistry, chemistry, computer science, and engineering. This is well illustrated by recent approaches to the measurement of DNA, RNA, proteins, and intact cells. Such successes underlie well founded visions of how molecular biology can further assist in answering compelling scientific questions and in enabling the development of remarkable advances in human health. These visions, in turn, are motivating the interdisciplinary creation of even more comprehensive measurements. As a further and closely related consequence, they are motivating innovations in the conceptual and practical approaches to organizing and visualizing large, complex sets of interrelated experimental results and distilling from those data compelling, informative conclusions.

  20. Complexity, Information and Biological Organisation

    Directory of Open Access Journals (Sweden)

    Attila Grandpierre


    Full Text Available Regarding the widespread confusion about the concept and nature of complexity, information and biological organization, we look for some coordinated conceptual considerations corresponding to quantitative measures suitable to grasp the main characteristics of biological complexity. Quantitative measures of algorithmic complexity of supercomputers like Blue Gene/L are compared with the complexity of the brain. We show that both the computer and the brain have a more fundamental, dynamic complexity measure corresponding to the number of operations per second. Recent insights suggest that the origin of complexity may go back to simplicity at a deeper level, corresponding to algorithmic complexity. We point out that for physical systems Ashby’s Law, Kahre’s Law and causal closure of the physical exclude the generation of information, and since genetic information corresponds to instructions, we are faced with a controversy telling that the algorithmic complexity of physics is much lower than the instructions’ complexity of the human DNA: I_algorithmic(physics ~ 10^3 bit << I_instructions(DNA ~ 10^9 bit. Analyzing the genetic complexity we obtain that actually the genetic information corresponds to a deeper than algorithmic level of complexity, putting an even greater emphasis to the information paradox. We show that the resolution of the fundamental information paradox may lie either in the chemical evolution of inheritance in abiogenesis, or in the existence of an autonomous biological principle allowing the production of information beyond physics.