WorldWideScience

Sample records for biogzes raoanas ies

  1. Modeling Continuous IED Supply Chains

    Science.gov (United States)

    2014-03-27

    criminals, pirates, drug traffickers and terrorists. Moreover, JIEDDO has pointed out the spread of IED use to places such as Thailand and Norway. U.S... human networks that place IEDs. Dekker categorizes two main human aspects of IED placement. The first is motivation which 8 affects the number of...methods provided in this thesis and apply them to combat other threats. For example, drug trafficking supply chains. IED and drug trafficking supply

  2. Roving UAV IED Interdiction System

    Science.gov (United States)

    2011-03-01

    protect both the troops and innocent civilian population from this insidious threat. UAVs may provide a fast , flexible platform for extending C-IED...considered to be 7,000 foot candles . Using the preceding data, the luminance of the UAV was estimated as the product of the illumination on the scene and...fuel. By looking at velocity over time, it was possible to see at what point level flight became possible as fuel burned off. Loiter velocity was

  3. The Yo-Yo IE2 test

    DEFF Research Database (Denmark)

    Krustrup, Peter; Bradley, Paul S; Christensen, Jesper F

    2015-01-01

    To examine the physical capacity and physiological response to the Yo-Yo Intermittent Endurance level 2 test (IE2) for untrained individuals and trained male soccer players, and to investigate the determinants of intense intermittent exercise performance.......To examine the physical capacity and physiological response to the Yo-Yo Intermittent Endurance level 2 test (IE2) for untrained individuals and trained male soccer players, and to investigate the determinants of intense intermittent exercise performance....

  4. IED blast postconcussive syncope and autonomic dysregulation.

    Science.gov (United States)

    Sams, Richard; LaBrie, D Walter; Norris, Jacob; Schauer, Judy; Frantz, Earl

    2012-01-01

    Concussions are the most frequent battle injury sustained in Afghanistan. The Concussion Restoration Care Center provides multidisciplinary care to concussed service members in theater. The Concussion Restoration Care Center has managed over 500 concussions, the majority being from improvised explosive device (IED) blasts. Syncope following a concussion without a loss of consciousness is rarely reported in the literature. The pathophysiology of concussion from a blast injury may be distinct from a concussion secondary to blunt trauma. Two cases of syncope following concussions with an alteration of consciousness are presented, and a mechanism of action is proposed. Post-IED blast concussive symptom frequency at initial presentation on a cohort of patients is reported, with 1.3% of patients experiencing postconcussive syncope. Syncope following an IED blast may be related to centrally mediated autonomic dysregulation at the brain stem level. Syncope should be added to the list of possible symptoms that occur following concussions, in particular concussions following a blast injury.

  5. Rehabilitación IES Númancia

    OpenAIRE

    García Hidalgo, Antonio

    2009-01-01

    El presente proyecto trata de la rehabilitación del instituto de educación secundaria y bachillerato IES Numancia, situado en la calle Prat de la Riba nº118 de la localidad de Santa Coloma de Gramenet (Barcelona).

  6. IE5技巧小集

    Institute of Scientific and Technical Information of China (English)

    朱运喜

    2000-01-01

    @@IE5已经是个"老"软件了,但笔者却发现很多用户只会使用几个有限的功能,影响了浏览效率,既浪费了时间,也浪费了money,实在不应该。鉴于此,笔者专门整理了一些这方面的常用技巧,希望能对大家有所帮助。

  7. POSTMODERNITATEA ÎN EDUCAŢIE

    Directory of Open Access Journals (Sweden)

    Vladimir Guțu

    2015-11-01

    Full Text Available În articol este abordată problema postmodernităţii în educaţie în contextul priorităţii laturii umane a educaţiei, lansării paradigmei curriculumului, promovării interdisciplinarităţii şi transdisciplinarităţii, redimensionării finalităţilor educaţiei, având competenţe ca un nou cadru de referinţă. Totodată, sunt analizate şi alte caracteristici ale postmodernităţii în educaţie din perspective filosofică, psihologică şi pedagogică. POSTMODERNITY IN EDUCATION In this article is approached the issue of postmodernity in education in the context of human side of education precedence, curriculum paradigm launch, promotion of interdisciplinarity and transdisciplinarity, resizing the aims of education, with competences as a new frame of reference. Yet there are analyzed other characteristics of postmodernity in education from the philosophical, psychological and pedagogical perspectives.

  8. ONR C-IED STIFLE (Stigmergic Tracking of IED Factories, Locations and Events

    Science.gov (United States)

    2009-06-19

    is straightforward to show (see, for example, F. Reif , Fundamentals of Statistical and Thermal Physics (McGraw-Hill, 1965)) that the diffusion...modeling approach within the TAEMS framework, a formal representation and reasoning mechanism for hierarchical task networks. Together with Prof. Bob...additional flavor used by these agents conveys a statistical long-term assessment of the level of IED threat (attractive) at a particular location. The

  9. Human cytomegalovirus IE2 protein interacts with transcription activating factors

    Institute of Scientific and Technical Information of China (English)

    XU; Jinping(徐进平); YE; Linbai(叶林柏)

    2002-01-01

    The human cytomegalovirus (HCMV) IE86 Cdna was cloned into Pgex-2T and fusion protein GST-IE86 was expressed in E. Coli. SDS-PAGE and Western blot assay indicated that fusion protein GST-IE86 with molecular weight of 92 ku is soluble in the supernatant of cell lysate. Protein GST and fusion protein GST-IE86 were purified by affinity chromatography. The technology of co-separation and specific affinity chromatography was used to study the interactions of HCMV IE86 protein with some transcriptional regulatory proteins and transcriptional factors. The results indicated that IE86 interacts separately with transcriptional factor TFIIB and promoter DNA binding transcription trans-activating factors SP1, AP1 and AP2 to form a heterogenous protein complex. These transcriptional trans-activating factors, transcriptional factor and IE86 protein were adsorbed and retained in the affinity chromatography simultaneously. But IE86 protein could not interact with NF-Кb, suggesting that the function of IE86 protein that can interact with transcriptional factor and transcriptional trans-activating factors has no relevance to protein glycosylation. IE86 protein probably has two domains responsible for binding transcriptional trans-activating regulatory proteins and transcriptional factors respectively, thus activating the transcription of many genes. The interactions accelerated the assembly of the transcriptional initiation complexes.

  10. The Post-Afghanistan IED Threat Assessment: Executive Summary

    Science.gov (United States)

    2013-05-01

    ponents and enhance the IED threat. To assess the impact of innova - tion, we analyzed three issues: 1. The development of IEDs in OIF and OEF; 2...short, the IED threat observed in Iraq, Afghanistan, and the home- land in recent years will likely persist regardless of technical innova - tions and

  11. Engineering tool for the evaluation of global IED effects

    Directory of Open Access Journals (Sweden)

    N. Heider

    2016-04-01

    The engineering tool is validated with small size generic vehicle tests where jump height and the vehicle motion are compared. The software allows a detailed analysis of global IED effects and can be additionally used in an inverse mode for the analysis of incidents with the determination of used HE masses in an IED attack.

  12. Validade convergente do Inventário de Empatia (IE)

    OpenAIRE

    Falcone,Eliane Mary de Oliveira; Pinho,Vanessa Dordron de; Ferreira, Maria Cristina; Fernandes,Conceição dos Santos; D'Augustin,Juliana Furtado; Krieger,Stèphanie; Plácido,Monique Gomes; Vianna,Keyth de Oliveira; Electo,Lucimar da Costa Torres; Pinheiro,Layse Costa

    2013-01-01

    O estudo teve como objetivo investigar a validade convergente do Inventário de Empatia. A amostra foi composta por 230 indivíduos adultos, de ambos os sexos, que responderam ao Inventário de Empatia (IE) e à Escala Multidimensional de Reatividade Interpessoal (EMRI). Correlações positivas e significativas fortes ou moderadas foram obtidas entre os fatores cognitivos do IE (Tomada de Perspectiva e Flexibilidade Interpessoal) e o fator cognitivo da EMRI. No entanto, os fatores afetivos do IE (A...

  13. La Inversion Extranjera Directa (IED, teorias y practicas.

    Directory of Open Access Journals (Sweden)

    De la Garza, U.

    2005-01-01

    Full Text Available En éste articulo, analizaremos algunas de las principales teorías relacionadas con la IED. Se destacarán principalmente los aportes teóricos en cuanto a posibles efectos positivos y negativos de la llegada de IED a economías receptoras. Al mismo tiempo, se tratará de resaltar y justificar la importancia de la llegada de nuevas inversiones a países en desarrollo como México, destacando los principales factores que propician la llegada de IED en países en desarrollo.

  14. The Future of JIEDDO - The Global C-IED Synchronizer

    Science.gov (United States)

    2008-10-31

    IED threat have evolved into one 1 William G. Adamson, An Asymetric Threat Invokes Strategic Leader...An Asymetric Threat Invokes Strategic Leader Initiative: The Joint Improvised Explosive Device Defeat Organization, (Washington, D.C. Industrial

  15. 告别MyIE2 TouchNet Browser

    Institute of Scientific and Technical Information of China (English)

    逆刃刀

    2004-01-01

    刚刚接解Internet的时候,只知道用微软强加给我们的IE浏览器。后来逐渐了解了,开始选择更好的MyIE2,一直和MyIE2相守走过了N个日日夜夜,直到发现了TouchNet Browser(以下简称TouchNet)。

  16. SpIES: The Spitzer IRAC Equatorial Survey

    CERN Document Server

    Timlin, John D; Richards, Gordon T; Lacy, Mark; Ryan, Erin L; Stone, Robert B; Bauer, Franz E; Brandt, W N; Fan, Xiaohui; Glikman, Eilat; Haggard, Daryl; Jiang, Linhua; LaMassa, Stephanie M; Lin, Yen-Ting; Makler, Martin; McGehee, Peregrine; Myers, Adam D; Schneider, Donald P; Urry, C Megan; Wollack, Edward J; Zakamska, Nadia L

    2016-01-01

    We describe the first data release from the Spitzer-IRAC Equatorial Survey (SpIES); a large-area survey of 115 deg^2 in the Equatorial SDSS Stripe 82 field using Spitzer during its 'warm' mission phase. SpIES was designed to probe sufficient volume to perform measurements of quasar clustering and the luminosity function at z > 3 to test various models for "feedback" from active galactic nuclei (AGN). Additionally, the wide range of available multi-wavelength, multi-epoch ancillary data enables SpIES to identify both high-redshift (z > 5) quasars as well as obscured quasars missed by optical surveys. SpIES achieves 5{\\sigma} depths of 6.13 {\\mu}Jy (21.93 AB magnitude) and 5.75 {\\mu}Jy (22.0 AB magnitude) at 3.6 and 4.5 microns, respectively - depths significantly fainter than WISE. We show that the SpIES survey recovers a much larger fraction of spectroscopically-confirmed quasars (98%) in Stripe 82 than are recovered by WISE (55%). This depth is especially powerful at high-redshift (z > 3.5), where SpIES reco...

  17. Integrated Energy Systems (IES) for Buildings: A Market Assessment

    Energy Technology Data Exchange (ETDEWEB)

    LeMar, P.

    2002-10-29

    Integrated Energy Systems (IES) combine on-site power or distributed generation technologies with thermally activated technologies to provide cooling, heating, humidity control, energy storage and/or other process functions using thermal energy normally wasted in the production of electricity/power. IES produce electricity and byproduct thermal energy onsite, with the potential of converting 80 percent or more of the fuel into useable energy. IES have the potential to offer the nation the benefits of unprecedented energy efficiency gains, consumer choice and energy security. It may also dramatically reduce industrial and commercial building sector carbon and air pollutant emissions and increase source energy efficiency. Applications of distributed energy and Combined heat and power (CHP) in ''Commercial and Institutional Buildings'' have, however, been historically limited due to insufficient use of byproduct thermal energy, particularly during summer months when heating is at a minimum. In recent years, custom engineered systems have evolved incorporating potentially high-value services from Thermally Activated Technologies (TAT) like cooling and humidity control. Such TAT equipment can be integrated into a CHP system to utilize the byproduct heat output effectively to provide absorption cooling or desiccant humidity control for the building during these summer months. IES can therefore expand the potential thermal energy services and thereby extend the conventional CHP market into building sector applications that could not be economically served by CHP alone. Now more than ever, these combined cooling, heating and humidity control systems (IES) can potentially decrease carbon and air pollutant emissions, while improving source energy efficiency in the buildings sector. Even with these improvements over conventional CHP systems, IES face significant technological and economic hurdles. Of crucial importance to the success of IES is the ability

  18. Roadside IED detection using subsurface imaging radar and rotary UAV

    Science.gov (United States)

    Qin, Yexian; Twumasi, Jones O.; Le, Viet Q.; Ren, Yu-Jiun; Lai, C. P.; Yu, Tzuyang

    2016-05-01

    Modern improvised explosive device (IED) and mine detection sensors using microwave technology are based on ground penetrating radar operated by a ground vehicle. Vehicle size, road conditions, and obstacles along the troop marching direction limit operation of such sensors. This paper presents a new conceptual design using a rotary unmanned aerial vehicle (UAV) to carry subsurface imaging radar for roadside IED detection. We have built a UAV flight simulator with the subsurface imaging radar running in a laboratory environment and tested it with non-metallic and metallic IED-like targets. From the initial lab results, we can detect the IED-like target 10-cm below road surface while carried by a UAV platform. One of the challenges is to design the radar and antenna system for a very small payload (less than 3 lb). The motion compensation algorithm is also critical to the imaging quality. In this paper, we also demonstrated the algorithm simulation and experimental imaging results with different IED target materials, sizes, and clutters.

  19. 魏德米勒HTx-IE-POF工具

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    魏德米勒为复杂的POF光纤联接件的组装提供了最佳的解决方案。魏德米勒提供了一整套坚固耐用的工具和完美的加工处理POF塑料物光纤。使用魏德米勒多功能工具套装multi-stripax IE-POF,HTX-IE-POF工具和Kevlar光纤剪刀,使得加工光纤接头和联接接头变得轻而易举。

  20. Engineering tool for the evaluation of global IED effects

    Institute of Scientific and Technical Information of China (English)

    N. HEIDER; V. DENEFELD; A. STEINBRENNER; A. HOLZWARTH

    2016-01-01

    The detonation of an IED near a military vehicle induces different damage effects on the vehicle and its occupants. There are local effects from fragments and projectiles but there are also global effects from a momentum transfer on the complete vehicle structure and a subsequent dynamical motion of the vehicle with phenomena like overturning or vehicle displacement from the road. Questions like this can be answered with numerical finite-element simulations but there is also the need for engineering tools that allow a quick and nearly instantaneous simulation of these phenomena. The following work presents an approach for a fast analysis of global IED effects on vehicles. The physical modelling is based on analytical formula and empirical data that describe the momentum transfer of a detonation on a nearby structure. This momentum is the initial condition for the calculation of the following vehicle motion and the simulation of vehicle dynamics and jump height. The software itself has a modern GUI that allows the generation of the vehicle structure and the threat scenario together with an interactive analysis of the simulation results. The engineering tool is validated with small size generic vehicle tests where jump height and the vehicle motion are compared. The software allows a detailed analysis of global IED effects and can be additionally used in an inverse mode for the analysis of incidents with the determination of used HE masses in an IED attack.

  1. Imaging Electron Spectrometer (IES) Electron Preprocessor (EPP) Design

    Science.gov (United States)

    Fennell, J. F.; Osborn, J. V.; Christensen, John L. (Technical Monitor)

    2001-01-01

    The Aerospace Corporation developed the Electron PreProcessor (EPP) to support the Imaging Electron Spectrometer (IES) that is part of the RAPID experiment on the ESA/NASA CLUSTER mission. The purpose of the EPP is to collect raw data from the IES and perform processing and data compression on it before transferring it to the RAPID microprocessor system for formatting and transmission to the CLUSTER satellite data system. The report provides a short history of the RAPID and CLUSTER programs and describes the EPP design. Four EPP units were fabricated, tested, and delivered for the original CLUSTER program. These were destroyed during a launch failure. Four more EPP units were delivered for the CLUSTER II program. These were successfully launched and are operating nominally on orbit.

  2. Targeting: Social Network Analysis in Counter IED Operations

    Science.gov (United States)

    2011-06-01

    JI’s East Java division, JI schools, and an old Darul Islam (DI) organization. This network, like the 2003 Marriott hotel bombing one, was based on...Terrorism DC Direct Centrality DI Darul Islam EFP Explosively Formed Penetrator FLN National Liberation Front IED Improvised Explosive...Ioannis Michaletos,“The International Islamic Jihad: The first global terrorist movement in history,” International Analyst Network (2010), http

  3. SUPERNOVA 2003ie WAS LIKELY A FAINT TYPE IIP EVENT

    Energy Technology Data Exchange (ETDEWEB)

    Arcavi, Iair; Gal-Yam, Avishay [Department of Particle Physics and Astrophysics, The Weizmann Institute of Science, Rehovot 76100 (Israel); Sergeev, Sergey G., E-mail: iair.arcavi@weizmann.ac.il [Crimean Astrophysical Observatory, P/O Nauchny, Crimea 98409 (Ukraine)

    2013-04-15

    We present new photometric observations of supernova (SN) 2003ie starting one month before discovery, obtained serendipitously while observing its host galaxy. With only a weak upper limit derived on the mass of its progenitor (<25 M{sub Sun }) from previous pre-explosion studies, this event could be a potential exception to the ''red supergiant (RSG) problem'' (the lack of high-mass RSGs exploding as Type IIP SNe). However, this is true only if SN2003ie was a Type IIP event, something which has never been determined. Using recently derived core-collapse SN light-curve templates, as well as by comparison to other known SNe, we find that SN2003ie was indeed a likely Type IIP event. However, with a plateau magnitude of {approx} - 15.5 mag, it is found to be a member of the faint Type IIP class. Previous members of this class have been shown to arise from relatively low-mass progenitors (<12 M{sub Sun }). It therefore seems unlikely that this SN had a massive RSG progenitor. The use of core-collapse SN light-curve templates is shown to be helpful in classifying SNe with sparse coverage. These templates are likely to become more robust as large homogeneous samples of core-collapse events are collected.

  4. The semantic development of IE *weid- to the meaning ‘know’ and the possible contrast with IE *gneh3-

    Directory of Open Access Journals (Sweden)

    Trinidad Silva

    2012-12-01

    Full Text Available This study is an attempt to trace the semantic development of the ie root *weid- and the possible contrast with the lexical pair *gneh3-. The analysis covers cross-linguistic comparison assessed diachronically in connection with historical linguistic phenomena and synchronically by the examination of two particular Greek authors, Homer and Plato, and some examples in the use of living languages such as Spanish, French and German.

  5. The Effect of Carbonate, Oxalate and Peroxide on the Cesium Loading of Ionsiv IE-910 and IE-911

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.F.

    2000-12-19

    The Savannah River Site (SRS) continues to examine three processes for the removal of radiocesium from high-level waste. One option involves the use of crystalline silicotitanate (CST) as a non-elutable ion exchange medium. The process uses CST in its engineered form - IONSIV IE-911 made by UOP, LLC. - in a column to contact the liquid waste. Cesium exchanges with sodium ions residing inside the CST particles. The design disposes of the cesium-loaded CST by vitrification within the Defense Waste Processing Facility.

  6. Reduction of global effects on vehicles after IED detonations

    Institute of Scientific and Technical Information of China (English)

    V.DENEFELD; N.HEIDER; A.HOLZWARTH; A.S€ATTLER; M.SALK

    2014-01-01

    Global effects caused by the detonation of an IED near a military vehicle induce subsequent severe acceleration effects on the vehicle occupants. Two concepts to minimize these global effects were developed, with the help of a combined method based on a scaled experimental technology and numerical simulations. The first concept consists in the optimization of the vehicle shape to reduce the momentum transfer and thus the occupant loading. Three scaled V-shaped vehicles with different ground clearances were built and compared to a reference vehicle equipped with a flat floor. The second concept, called dynamic impulse compensation (DIC), is based on a momentum compensation technique. The principal possibility of this concept was demonstrated on a scaled vehicle. In addition, the numerical simulations have been performed with generic full size vehicles including dummy models, proving the capability of the DIC technology to reduce the occupant loading.

  7. IDENTIFICATION OF EMPLOYEES USING RFID IN IE-NTUA

    Directory of Open Access Journals (Sweden)

    Rashid Ahmed

    2013-11-01

    Full Text Available During the last decade with the rapid increase in indoor wireless communications, location-aware services have received a great deal of attention for commercial, public-safety, and a military application, the greatest challenge associated with indoor positioning methods is moving object data and identification. Mobility tracking and localization are multifaceted problems, which have been studied for a long time in different contexts. Many potential applications in the domain of WSNs require such capabilities. The mobility tracking needs inherent in many surveillance, security and logistic applications. This paper presents the identification of employees in National Technical University in Athens (IE-NTUA, when the employees access to a certain area of the building (enters and leaves to/from the college, Radio Frequency Identification (RFID applied for identification by offering special badges containing RFID-tags.

  8. Networking strategy for entrepreneurship education in the IES

    Directory of Open Access Journals (Sweden)

    Ana María Holguín Montoya

    2014-08-01

    Full Text Available In order to strengthen the processes of entrepreneurship developed in different institutions of higher education and improving the entrepreneurial model of the city of Medellín, institutions like the Mayor’s Office and COMFAMA (Family Benefit Institution, unite to add economic efforts and management in order to lead the program called City E. The overall objective of the program is to establish measures aimed at improving skills and abilities in the different actors of entrepreneurship in higher education institutions of the IES city. Unify criteria and that the capacity on issues related to entrepreneurship and the creation of productive and competitive enterprises. To this end, the Bolivarian Pontifical University makes tracing models of entrepreneurship in HEIs nationally and internationally and designed and implemented from the results of research conducted by the UPB a curriculum model and comprehensive support for the creation companies. 

  9. Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses.

    Science.gov (United States)

    Torres, Lilith; Tang, Qiyi

    2014-12-01

    Three crucial hurdles hinder studies on human cytomegalovirus (HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was first accomplished, functional studies on individual genes have been the mainstream in the CMV field. Gene regulation has therefore been elucidated in a more detailed fashion. However, viral gene regulation is largely controlled by both cellular and viral components. In other words, viral gene expression is determined by the virus-host interaction. Generally, cells respond to viral infection in a defensive pattern; at the same time, viruses try to counteract the cellular defense or else hide in the host (latency). Viruses evolve effective strategies against cellular defense in order to achieve replicative success. Whether or not they are successful, cellular defenses remain in the whole viral replication cycle: entry, immediate-early (IE) gene expression, early gene expression, DNA replication, late gene expression, and viral egress. Many viral strategies against cellular defense, and which occur in the immediate-early time of viral infection, have been documented. In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.

  10. Immediate–Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses

    Science.gov (United States)

    Torres, Lilith; Tang, Qiyi

    2015-01-01

    Three crucial hurdles hinder studies on human cytomegalovirus (HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was first accomplished, functional studies on individual genes have been the mainstream in the CMV field. Gene regulation has therefore been elucidated in a more detailed fashion. However, viral gene regulation is largely controlled by both cellular and viral components. In other words, viral gene expression is determined by the virus–host interaction. Generally, cells respond to viral infection in a defensive pattern; at the same time, viruses try to counteract the cellular defense or else hide in the host (latency). Viruses evolve effective strategies against cellular defense in order to achieve replicative success. Whether or not they are successful, cellular defenses remain in the whole viral replication cycle: entry, immediate–early (IE) gene expression, early gene expression, DNA replication, late gene expression, and viral egress. Many viral strategies against cellular defense, and which occur in the immediate–early time of viral infection, have been documented. In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses. PMID:25501994

  11. Immediate–Early(IE) gene regulation of cytomegalovirus:IE1-and pp71-mediated viral strategies against cellular defenses

    Institute of Scientific and Technical Information of China (English)

    Lilith; Torres; Qiyi; Tang

    2014-01-01

    Three crucial hurdles hinder studies on human cytomegalovirus(HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was first accomplished, functional studies on individual genes have been the mainstream in the CMV field. Gene regulation has therefore been elucidated in a more detailed fashion. However, viral gene regulation is largely controlled by both cellular and viral components. In other words, viral gene expression is determined by the virus–host interaction. Generally, cells respond to viral infection in a defensive pattern; at the same time, viruses try to counteract the cellular defense or else hide in the host(latency). Viruses evolve effective strategies against cellular defense in order to achieve replicative success. Whether or not they are successful, cellular defenses remain in the whole viral replication cycle: entry, immediate–early(IE) gene expression, early gene expression, DNA replication, late gene expression, and viral egress. Many viral strategies against cellular defense, and which occur in the immediate–early time of viral infection, have been documented. In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.

  12. PECULIARITIES OF CONSTRUCTION OF INSTITUTIONS OF SECONDARY EDUCATION IN MOSCOW IN THE 1920IES AND 1930IES

    Directory of Open Access Journals (Sweden)

    Byzova Ol'ga Mikhaylovna

    2012-10-01

    Full Text Available Actions aimed at the generality of elementary education in the course of the period days of the industrialization and cultural revolution in the USSR is under discussion in the proposed paper. On the basis of the archived documents, organization of construction of school buildings in Moscow in the 20ies and 30ies of the 20th century is analyzed. It is noteworthy that industrialization in the periods of the first, second and third five-year plans reshaped the country and Moscow as its capital. Former suburbs turned into large industrial areas that had giant factories and housing built around them to accommodate workers. Thus, the population of Moscow grew in numbers. The need for competent staff facilitated construction of new schools. Peculiarities of school construction in Moscow within the first five-year plan are considered in article on the basis of a school building in Likhobory in 1932. The school building design, work progress, assembly and interior, deadlines and problems of construction are specified. It is noteworthy that, despite any difficulties, 19 new school buildings were completed in Moscow in the years of the first five-year plan. Classes were organized according to the principle of two shifts to implement the general education programme in 1932.

  13. Multi-spectral texture analysis for IED detection

    Science.gov (United States)

    Petersson, Henrik; Gustafsson, David

    2016-10-01

    The use of Improvised Explosive Devices (IEDs) has increased significantly over the world and is a globally widespread phenomenon. Although measures can be taken to anticipate and prevent the opponent's ability to deploy IEDs, detection of IEDs will always be a central activity. There is a wide range of different sensors that are useful but also simple means, such as a pair of binoculars, can be crucial to detect IEDs in time. Disturbed earth (disturbed soil), such as freshly dug areas, dumps of clay on top of smooth sand or depressions in the ground, could be an indication of a buried IED. This paper brie y describes how a field trial was set-up to provide a realistic data set on a road section containing areas with disturbed soil due to buried IEDs. The road section was imaged using a forward looking land-based sensor platform consisting of visual imaging sensors together with long-, mid-, and shortwave infrared imaging sensors. The paper investigates the presence of discriminatory information in surface texture comparing areas with disturbed against undisturbed soil. The investigation is conducted for the different wavelength bands available. To extract features that describe texture, image processing tools such as 'Histogram of Oriented Gradients', 'Local Binary Patterns', 'Lacunarity', 'Gabor Filtering' and 'Co-Occurence' is used. It is found that texture as characterized here may provide discriminatory information to detect disturbed soil, but the signatures we found are weak and can not be used alone in e.g. a detector system.

  14. An affordable modular vehicle radar for landmine and IED detection

    Science.gov (United States)

    Daniels, David; Curtis, Paul; Dittmer, Jon; Hunt, Nigel; Graham, Blair; Allan, Robert

    2009-05-01

    This paper describes a vehicle mounted 8-channel radar system suitable for buried landmine and IED detection. The system is designed to find Anti Tank (AT) landmines and buried Improvised Explosive Devices (IEDs). The radar uses field-proven ground penetrating radar sub-system modules and is scalable to 16, 32 or 64 channels, for covering greater swathe widths and for providing higher cross track resolution. This offers the capability of detecting smaller targets down to a minimum dimension of 100mm. The current rate of advance of the technology demonstrator is 10 kph; this can be increased to 20 kph where required. The data output is triggered via shaft encoder or via GPS and, for each forward increment; the data output is variable from a single byte per channel through to the 512 samples per channel. Trials using an autonomous vehicle, combined with a COFDM wireless link for data and telemetry back to a base station, have proven successful and the system architecture is described in this paper. The GPR array can be used as a standalone sensor or can be integrated with off-the-shelf software and a metal detection array.

  15. Feasibility of culvert IED detection using thermal neutron activation

    Science.gov (United States)

    Faust, Anthony A.; McFee, John E.; Clifford, Edward T. H.; Andrews, Hugh Robert; Mosquera, Cristian; Roberts, William C.

    2012-06-01

    Bulk explosives hidden in culverts pose a serious threat to the Canadian and allied armies. Culverts provide an opportunity to conceal insurgent activity, avoid the need for detectable surface disturbances, and limit the applicability of conventional sub-surface sensing techniques. Further, in spite of the large masses of explosives that can be employed, the large sensor{target separation makes detection of the bulk explosive content challeng- ing. Defence R&D Canada { Sueld and Bubble Technology Industries have been developing thermal neutron activation (TNA) sensors for detection of buried bulk explosives for over 15 years. The next generation TNA sensor, known as TNA2, incorporates a number of improvements that allow for increased sensor-to-target dis- tances, making it potentially feasible to detect large improvised explosive devices (IEDs) in culverts using TNA. Experiments to determine the ability of TNA2 to detect improvised explosive devices in culverts are described, and the resulting signal levels observed for relevant quantities of explosives are presented. Observations conrm that bulk explosives detection using TNA against a culvert-IED is possible, with large charges posing a detection challenge at least as dicult as that of a deeply buried anti-tank landmine. Because of the prototype nature of the TNA sensor used, it is not yet possible to make denitive statements about the absolute sensitivity or detection time. Further investigation is warranted.

  16. Environmental Project of I.E.S. Antoni Maura

    Science.gov (United States)

    Crespi Salom, Pere

    2010-05-01

    Environmental Project of I.E.S. Antoni Maura Author(s): Pere Crespí i Salom Teacher of Department of Biology and Geology and Environmental Coordinator (2009-2010) from I.E.S. Antoni Maura . Mallorca. Illes Balears. Spain Teachers participating in the project : Myriam Fuentes Milani, Olga Ballester Nebot, Antoni Salom Ruiz, Julio René Loayza Casanova, Puy Aguirre Rémirez, Yolanda Martínez Laserna, Jaume Puppo Lama, Carme Arrom , Dolors Aguiló Segura, Marga Ordinas Boter, Angel Fernàndez Albertí , Immaculada Suau López, Antònia Florit Torrandell, Isabel Mateu Arcos, Román Piña Valls i Pere Crespí Salom. Our institute takes part since 2004 in adapting environmentally the schools in the Balearics which consists of developing activities which aim is that both teachers and students acquire habits so as to apply to their ordinary lives though different participative commissions ( 10-15 teachers): 1st commission: recycling and reusing materials. Enough bins in the classrooms and floors: yellow for plastic, blue for paper, and green for the other. We tend to use recycled materials in different celebrations such as Carnival, Christmas, Saint Jordi and Environmental day. We also organise workshops for the teachers to develop afterwards with the students and nature of environmental exposures. 2nd commission: Scatter information ( MonMaura, Maurifull, Green window and website).Throughout different means we inform the teachers and students about all the school activities and where to consult.( www.iesantonimaura.net, Playful area , environmental project ). 3rd commission: Reusing text books.( there is a students service of borrowing books and giving them back at the end of the school year if the book is in good use.) 4th commission: Improving the school surroundings, the back garden and garden with native plants. Department of Biology and Geology is responsible for caring for an organic garden and in turn improve the center's garden with native plants within the

  17. SIRE: a MIMO radar for landmine/IED detection

    Science.gov (United States)

    Ojowu, Ode; Wu, Yue; Li, Jian; Nguyen, Lam

    2013-05-01

    Multiple-input multiple-output (MIMO) radar systems have been shown to have significant performance improvements over their single-input multiple-output (SIMO) counterparts. For transmit and receive elements that are collocated, the waveform diversity afforded by this radar is exploited for performance improvements. These improvements include but are not limited to improved target detection, improved parameter identifiability and better resolvability. In this paper, we present the Synchronous Impulse Reconstruction Radar (SIRE) Ultra-wideband (UWB) radar designed by the Army Research Lab (ARL) for landmine and improvised explosive device (IED) detection as a 2 by 16 MIMO radar (with collocated antennas). Its improvement over its SIMO counterpart in terms of beampattern/cross range resolution are discussed and demonstrated using simulated data herein. The limitations of this radar for Radio Frequency Interference (RFI) suppression are also discussed in this paper. A relaxation method (RELAX) combined with averaging of multiple realizations of the measured data is presented for RFI suppression; results show no noticeable target signature distortion after suppression. In this paper, the back-projection (delay and sum) data independent method is used for generating SAR images. A side-lobe minimization technique called recursive side-lobe minimization (RSM) is also discussed for reducing side-lobes in this data independent approach. We introduce a data-dependent sparsity based spectral estimation technique called Sparse Learning via Iterative Minimization (SLIM) as well as a data-dependent CLEAN approach for generating SAR images for the SIRE radar. These data-adaptive techniques show improvement in side-lobe reduction and resolution for simulated data for the SIRE radar.

  18. Analysis of the CoIE1 stability determinant Rcd.

    Science.gov (United States)

    Sharpe, M E; Chatwin, H M; Macpherson, C; Withers, H L; Summers, D K

    1999-08-01

    Multimer formation is an important cause of instability for many multicopy plasmids. Plasmid CoIE1 is maintained stably because multimers are converted to monomers by Xer-mediated site-specific recombination at the cer site. However, multimer resolution is not the whole story; inactivation of a promoter (Pcer) within cer causes plasmid instability even though recombination is unaffected. The promoter directs the synthesis of a short transcript (Rcd) which is proposed to delay the division of multimer-containing cells. Mapping of the 5' terminus of Rcd confirms that transcription initiates from Pcer. The 3' terminus shows considerable heterogeneity, consistent with a primary transcript of 95 nt being degraded via intermediates of 79 and 70 nt. Secondary structure predictions for Rcd are presented. Of four mutations which abolish Rcd-mediated growth inhibition, one reduces the activity of Pcer while the other three map to the rcd coding sequence and reduce the steady-state level of the transcript. RNA folding analysis suggests that these three mutant transcripts adopt a common secondary structure in which the major stem-loop differs from that of wild-type Rcd. A survey of 24 cer-like multimer resolution sites revealed six which contain Pcer-like sequences. The putative transcripts from these sites have similar predicted secondary structures to Rcd and contain a highly conserved 15 base sequence. To test the hypothesis that Rcd acts as an anti-sense RNA, interacting with its target gene(s) through the 15 nt sequence, we used DNA hybridization and sequence analysis to find matches to this sequence in the Escherichia coli chromosome. Our failure to find plausible anti-sense targets has led to the suggestion that Rcd may interact directly with a protein target.

  19. An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity.

    Science.gov (United States)

    Wan, Xinyue; Yin, Jieyun; Foreman, Robert; Chen, Jiande D Z

    2017-05-25

    This paper aims to optimize stimulation parameters and durations for intestinal electrical stimulation (IES) and to explore the effects and mechanisms of chronic IES with optimized methodology in obesity rats. Sixteen diet-induced obese (DIO) rats were tested for food intake with four different sets of IES parameters each lasting 1 week. Then, another 12 DIO rats were used to test the effect of IES on food intake with different stimulation durations. Finally, 16 DIO rats were treated with IES or sham-IES for 4 weeks. Meal patterns, food intake, and body weight were observed. Mechanisms involving gastrointestinal motility, ghrelin, and glucagon-like peptide-1 (GLP-1) were studied. (1) Acute IES with different parameters showed different inhibitory effects on food intake, and the most effective parameters were 0.6 s on, 0.9 s off, 80 Hz, 2 ms, and 4 mA with which 26.3% decrease in food intake was noted (p food intake compared with 1 or 6 h. (3) Four-week IES reduced net weight by 10.9% (p food intake and body weight in DIO rats by altering gastrointestinal motility and GLP-1. The IES methodology derived in this study may have a therapeutic potential for obesity.

  20. Identification and HLA-Tetramer-Validation of Human CD4(+) and CD8(+) T Cell Responses against HCMV Proteins IE1 and IE2

    DEFF Research Database (Denmark)

    Braendstrup, Peter; Mortensen, Bo Kok; Justesen, Sune Frederik Lamdahl

    2014-01-01

    tumor development. Both CD4(+) and CD8(+) T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8(+) T cell......Human cytomegalovirus (HCMV) is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants. Moreover, it has recently been suggested that HCMV may promote...... responses against the pp65 phosphoprotein. In this study, we have focused on CD4(+) and CD8(+) T cell responses against the immediate early 1 and 2 proteins (IE1 and IE2). Using overlapping peptides spanning the entire IE1 and IE2 sequences, peripheral blood mononuclear cells from 16 healthy, HLA...

  1. Data of evolutionary structure change: 1IE3A-1LLDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1IE3A-1LLDA 1IE3 1LLD A A -MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAP-...VGATVNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKL---TGL-PENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGD-SEVPLWESATIGGVPMSDWTPLPGHDPLDA...bChain>A 1LLDA EDIAKERVEAE 1LLD A 1LLDA A 1LLDA QIFGSGTNLDS EE

  2. Hittite huelpi- “Young, tender, fresh” and ie +Hulp-, +Hlup-

    Directory of Open Access Journals (Sweden)

    Metka Furlan

    1984-12-01

    Full Text Available The following contribution offers a new etymology of the Hittite term huelpi- which can through  IE root +Huelep- be related to IE +Hulp-, +Hlup- »fox, wolf, cat«.The relation indicates that the old expression for naming offerings to the gods is hidden in the IE forms +Hulp-, +Hlup-.

  3. Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ).

    Science.gov (United States)

    Coccaro, Emil F; Berman, Mitchell E; McCloskey, Michael S

    2017-04-01

    This study was designed to develop and test a screening approach to identify individuals with DSM-5 Intermittent Explosive Disorder (IED), a disorder of recurrent, problematic, impulsive aggression. A screening approach to diagnose DSM-5 IED (IED-SQ) was developed by combining items related to life history of aggression and items related to the DSM-5 diagnostic criteria for IED. In study 1, the IED-SQ was studied in 72 adult participants; 33 that met DSM-5 criteria for lifetime IED and 39 that did not. In study 2, the IED-SQ was given to 740 undergraduates at a US university. Measures of aggression and anger expression and anger control were assessed in both studies. In study 1, the IED-SQ demonstrated strong concordance with the best estimate diagnoses (Kappa =.80) for lifetime IED by DSM-5 criteria and good test-retest reliability (kappa =0.71). In study 2, the IED-SQ identified 4.3% of the undergraduate sample as meeting DSM-5 criteria for lifetime IED, a rate comparable to that in recent epidemiological studies. Participants identified as meeting DSM-5 criteria for lifetime IED, in both studies, had higher aggression scores, and higher anger expression, and lower anger control scores, compared to participants that did not meet DSM-5 criteria for lifetime IED. These data suggest that the IED-SQ is a useful screening tool that can quickly identify the presence of IED by DSM-5 criteria in adults. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against HCMV proteins IE1 and IE2.

    Directory of Open Access Journals (Sweden)

    Peter Braendstrup

    Full Text Available Human cytomegalovirus (HCMV is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants. Moreover, it has recently been suggested that HCMV may promote tumor development. Both CD4+ and CD8+ T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8+ T cell responses against the pp65 phosphoprotein. In this study, we have focused on CD4+ and CD8+ T cell responses against the immediate early 1 and 2 proteins (IE1 and IE2. Using overlapping peptides spanning the entire IE1 and IE2 sequences, peripheral blood mononuclear cells from 16 healthy, HLA-typed, donors were screened by ex vivo IFN-γ ELISpot and in vitro intracellular cytokine secretion assays. The specificities of CD4+ and CD8+ T cell responses were identified and validated by HLA class II and I tetramers, respectively. Eighty-one CD4+ and 44 CD8+ T cell responses were identified representing at least seven different CD4 epitopes and 14 CD8 epitopes restricted by seven and 11 different HLA class II and I molecules, respectively, in total covering 91 and 98% of the Caucasian population, respectively. Presented in the context of several different HLA class II molecules, two epitope areas in IE1 and IE2 were recognized in about half of the analyzed donors. These data may be used to design a versatile anti-HCMV vaccine and/or immunotherapy strategy.

  5. 41 CFR 301-11.101 - What allowance will I be paid for M&IE?

    Science.gov (United States)

    2010-07-01

    ... paid for M&IE? 301-11.101 Section 301-11.101 Public Contracts and Property Management Federal Travel... Lodgings-Plus Per Diem § 301-11.101 What allowance will I be paid for M&IE? (a) Except as provided in... allowance is More than 12 but less than 24 hours 75 percent of the applicable M&IE rate for each...

  6. Identification and HLA-Tetramer-Validation of Human CD4(+) and CD8(+) T Cell Responses against HCMV Proteins IE1 and IE2

    DEFF Research Database (Denmark)

    Braendstrup, Peter; Mortensen, Bo Kok; Justesen, Sune Frederik Lamdahl;

    2014-01-01

    tumor development. Both CD4(+) and CD8(+) T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8(+) T cell......-typed, donors were screened by ex vivo IFN-gamma ELISpot and in vitro intracellular cytokine secretion assays. The specificities of CD4(+) and CD8(+) T cell responses were identified and validated by HLA class II and I tetramers, respectively. Eighty-one CD4(+) and 44 CD8(+) T cell responses were identified...... in IE1 and IE2 were recognized in about half of the analyzed donors. These data may be used to design a versatile anti-HCMV vaccine and/or immunotherapy strategy....

  7. Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2

    Institute of Scientific and Technical Information of China (English)

    Sung-Bau Lee; Li-Jung Juan; Chung-Fan Lee; Derick S-C Ou; Kalpana Dulal; Liang-Hao Chang; Chen-Han Ma; Chien-Fu Huang; Hua Zhu; Young-Sun Lin

    2011-01-01

    Chromatin assembly factor 1 (CAF1) consisting of p150, p60 and p48 is known to assemble histones onto newly synthesized DNA and thus maintain the chromatin structure. Here, we show that CAF1 expression was induced in human cytomegalovirus (HCMV)-infected cells, concomitantly with global chromatin decondensation. This apparent conflict was thought to result, in part, from CAF1 mislocalization to compartments of HCMV DNA synthesis through binding of its largest subunit p150 to viral immediate-early protein 2 (IE2). p150 interaction with p60 and IE2 facilitated HCMV DNA synthesis. The IE2Q548R mutation, previously reported to result in impaired HCMV growth with unknown mechanism, disrupted IE2/p150 and IE2/histones association in our study. Moreover, IE2 interaction with histones partly depends on p150, and the HCMV-induced chromatin decondensation was reduced in cells ectopically expressing the p150 mutant defective in IE2 binding. These results not only indicate that CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1.

  8. Systematic study for DNA recovery and profiling from common IED substrates: From laboratory to casework.

    Science.gov (United States)

    Phetpeng, Sukanya; Kitpipit, Thitika; Thanakiatkrai, Phuvadol

    2015-07-01

    Improvised explosive devices (IEDs) made from household items are encountered in terrorist attacks worldwide. Assembling an IED leaves trace DNA on its components, but deflagration degrades DNA. To maximize the amount of DNA recovered, a systematic evaluation of DNA collection methods was carried out and the most efficient methods were implemented with IED casework evidence as a validation exercise. Six swab types and six moistening agents were used to collect dried buffy coat stains on four common IED substrates. The most efficient swab/moistening agent combinations were then compared with tape-lifting using three brands of adhesive tape and also with direct DNA extraction from evidence. The most efficient collection methods for different IED substrates (post-study protocol) were then implemented for IED casework and compared with the pre-study protocol using 195 pieces of IED evidence. There was no single best swab type or moistening agent. Swab type had the largest effect on DNA recovery percentages, but moistening agents, substrates, and the interactions between factors all affected DNA recovery. The most efficient swab/moistening agent combinations performed equally well when compared with the best adhesive tape and direct extraction. The post-study protocol significantly improved STR profiles obtained from IED evidence. This paper outlines a comprehensive study of DNA collection methods for trace DNA and the validation of the most efficient collection methods with IED evidence. The findings from both parts of this study emphasize the need to continuously re-evaluate standard operating protocols with empirical studies.

  9. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Wang, Weimin; Zhang, Jian; Mendon, Vrushali V.; Athalye, Rahul A.; Xie, YuLong; Hart, Reid; Goel, Supriya

    2014-03-01

    This report provides a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IES Standard 90.1-2010.

  10. Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein

    Institute of Scientific and Technical Information of China (English)

    Derick Shi-Chen Ou; Sung-Bau Lee; Chi-Shuen Chu; Liang-Hao Chang; Bon-chu Chung; Li-Jung Juan

    2011-01-01

    Glucose-regulated protein 78 (GRP78), a key regulator of endoplasmic reticulum (ER) stress, facilitates cancer cell growth and viral replication. The mechanism leading to grp78 gene activation during viral infection is largely unknown, in this study, we show that the immediate-early 1 (IE1-72) protein of the human cytomegalovirus (HCMV) is essential for HCMV-mediated GRP78 activation. IE1-72 upregulated grp 78 gene expression depending on the ATPbinding site, the zinc-finger domain and the putative leucine-zipper motif of IE1-72, as well as the ER stress response elements (ERSEs) on the grp78 promoter. The purified IE1-72 protein bound to the CCAAT box within ERSE in vitro, whereas deletion mutants of IE1-72 deficient in grp78 promoter stimulation failed to do so. Moreover, IE1-72 binding to the grp78 promoter in infected cells accompanied the recruitment of TATA box-binding protein-associated factor 1 (TAF1), a histone acetyltransferase, and the increased level of acetylated histone H4, an indicator of activestate chromatin. These results provide evidence that HCMV IE1-72 activates grp78 gene expression through direct promoter binding and modulation of the local chromatin structure, indicating an active viral mechanism of cellular chaperone induction for viral growth.

  11. Purification of an active fragment of Cry1Ie toxin from Bacillus thuringiensis.

    Science.gov (United States)

    Guo, Shuyuan; Zhang, Chunlu; Lin, Xiaoyin; Zhang, Yanrui; He, Kanglai; Song, Fuping; Zhang, Jie

    2011-08-01

    The cry1I genes from Bacillus thuringiensis are a class of special genes with unique characteristics; they are silent in B. thuringiensis strains but can be over-expressed in Escherichia coli, resulting in a Cry1I-type protein with a molecular mass of approximately 81kDa. Cry1I-type protein is toxic to Lepidoptera larvae. A truncated Cry1Ie protein, IE648, which corresponds to the first 648 amino acids from the N-terminus of Cry1Ie, was purified from E. coli using Ni-NTA affinity isolation, Q-Sepharose Fast Flow chromatography, and Superdex-200 size-exclusion chromatography. It was determined using laboratory bioassays that the purified IE648 protein has good insecticidal activity. Heterologous competitive binding assays show that IE648 does not compete with Cry1Ac for binding to the brush border membrane vesicles of the Asian corn borer and does not compete with Cry1Ac at concentrations below a 500-fold excess of unlabeled Cry1Ac for binding to the peritrophic matrix of the insect. This result implies that IE648 may be a good candidate as part of a multiple-toxin strategy for the potential control of resistance in insect pests. The method of purification reported here is valuable for further research on the structure and function of IE648 and in evaluating the biosafety of this protein within transgenic plants. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. The Sixth International Conference on Intelligent Environments (IE 10): A Report

    OpenAIRE

    Callaghan, Vic; University of Essex; Egerton, Simon; Monash University; Kameas, Achilles; Hellenic Open University; Satoh, Ichiro; National Institute of Informatics

    2011-01-01

    The 6th International Conference on Intelligent Environments (IE10) was held July 19-21 at the Sunway campus of Monash University, Kuala Lumpur, Malaysia. This article presents a report of the conference.

  13. "Virtual IED sensor" at an rf-biased electrode in low-pressure plasma

    Science.gov (United States)

    Bogdanova, M. A.; Lopaev, D. V.; Zyryanov, S. M.; Rakhimov, A. T.

    2016-07-01

    Energy distribution and the flux of the ions coming on a surface are considered as the key-parameters in anisotropic plasma etching. Since direct ion energy distribution (IED) measurements at the treated surface during plasma processing are often hardly possible, there is an opportunity for virtual ones. This work is devoted to the possibility of such indirect IED and ion flux measurements at an rf-biased electrode in low-pressure rf plasma by using a "virtual IED sensor" which represents "in-situ" IED calculations on the absolute scale in accordance with a plasma sheath model containing a set of measurable external parameters. The "virtual IED sensor" should also involve some external calibration procedure. Applicability and accuracy of the "virtual IED sensor" are validated for a dual-frequency reactive ion etching (RIE) inductively coupled plasma (ICP) reactor with a capacitively coupled rf-biased electrode. The validation is carried out for heavy (Ar) and light (H2) gases under different discharge conditions (different ICP powers, rf-bias frequencies, and voltages). An EQP mass-spectrometer and an rf-compensated Langmuir probe (LP) are used to characterize plasma, while an rf-compensated retarded field energy analyzer (RFEA) is applied to measure IED and ion flux at the rf-biased electrode. Besides, the pulsed selfbias method is used as an external calibration procedure for ion flux estimating at the rf-biased electrode. It is shown that pulsed selfbias method allows calibrating the IED absolute scale quite accurately. It is also shown that the "virtual IED sensor" based on the simplest collisionless sheath model allows reproducing well enough the experimental IEDs at the pressures when the sheath thickness s is less than the ion mean free path λi (s λi), the difference between calculated and experimental IEDs due to ion collisions in the sheath is observed in the low energy range. The effect of electron impact ionization in the sheath on the origin and

  14. Soil Protection in the EU According to the Directive on Industrial Emissions (IED and Croatian Practice

    Directory of Open Access Journals (Sweden)

    Ivan Pilaš

    2014-06-01

    Full Text Available Background and Purpose: Soil protection against pollution in EU is mostly covered in a new Directive on industrial emissions (IED, adopted on November 24, 2010 as a follow up of the IPPC Directive. For all industrial facilities that fall under IED, the Directive obliges the establishment of a complex system of management of contaminated soil at the national level, in order to facilitate the implementation of the principle of “polluter pays” furthermore to reduce the risk of contamination of soil and groundwater. Material and Methods: This paper presents an overview of soil management system that should be established in each EU country to fulfil IED requirements. It consists of a meta-analysis of IED requirements and current state and drawbacks of soil protection in Croatia including present state of legislation, responsibility of authorities, soil surveys and remediation activities. Results and Conclusions: IED set the obligation on the industrial operator before the start of production to prepare a report on the initial state of soil as a necessary requirement for obtaining environmental permit. It set obligations for monitoring of soil and groundwater status in the location of industrial facility for a period of ten (soil and five years (groundwater. After the cessation of production, and in the case of exceeding critical limits of pollution, the operator is obliged to perform remediation or restitution of land in the state as it was at the beginning of production. Management of contaminated soil according to IED requirements obliges the Croatian government to establish a complex multi-level system. At first it requires better definition of responsibilities between two ministries; Ministry of Environmental and Nature protection and Ministry of Agriculture. IED requires enactment of adequate legal basis (i.e. Soil protection act and the establishment of operational instruments for the implementation of soil protection, such as a register

  15. The Realisation of Editing MS Word Document in IE/Domino System%IE/Domino系统中Word文档编辑功能的实现

    Institute of Scientific and Technical Information of China (English)

    陈湘骥; 韩国强

    2003-01-01

    针对目前以IE/Domino方式构建的办公自动化系统中, IE与Domino不能支持客户端在线且实时编辑Word文档的问题,提出一种高效可行的解决方案.该方案的核心是通过以COM技术开发的客户端控件和以Lotus C + + API for Domino技术开发的Domino扩展服务器,构成一个解决问题的功能子系统.文章先介绍上述两种技术,然后建立系统模型,最后给出系统的技术实现.

  16. Applications of IES600 system in Longyan power grid%IES600系统在龙岩电网的应用

    Institute of Scientific and Technical Information of China (English)

    严翠云

    2012-01-01

    IES600 system combines Longyan power grid mode transition in the existing SCADA system, for how quickly and effectively to improve the power grid monitoring judgment in order to ensure grid security and stability of purpose. Based on the information in the power grid, data processing, continuous improvement. Data center and application integration environment are built, data integration, exchange, sharing, on-line application support and data analysis show, information dissemination are implemented. It greatly improves the power grid dispatching persons analysis of incident information and judgment.%IES600系统结合龙岩电网模式的转换,在原有调度自动化系统的基础上,针对如何快速有效提高电网监控判断力,以保证电网安全稳定运行为目的.在电网信息、数据处理上不断完善,建成了数据中心和应用集成环境,实现数据整合、交换、共享、联机应用支持及数据分析展现、信息发布.大大提高了电网调度人员对事故信息的分析和判断力,有利于电网事故的快速判断和处理,减少停电时间.对全国地区电网运行集中监控的实用化推广具有重要意义.

  17. Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.

    Science.gov (United States)

    Moghadam, Keivan Kaveh; Pizza, Fabio; La Morgia, Chiara; Franceschini, Christian; Tonon, Caterina; Lodi, Raffaele; Barboni, Piero; Seri, Marco; Ferrari, Simona; Liguori, Rocco; Donadio, Vincenzo; Parchi, Piero; Cornelio, Ferdinando; Inzitari, Domenico; Mignarri, Andrea; Capocchi, Giuseppe; Dotti, Maria Teresa; Winkelmann, Juliane; Lin, Ling; Mignot, Emmanuel; Carelli, Valerio; Plazzi, Giuseppe

    2014-06-01

    We report on the extensive phenotypic characterization of five Italian patients from four unrelated families carrying dominant heterozygous DNMT1 mutations linked to two distinct autosomal dominant diseases: hereditary sensory and autonomic neuropathy with dementia and hearing loss type IE (HSAN IE) and autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN). Patients underwent genetic analysis of DNMT1 gene, neurophysiological tests investigating sleep, auditory functions and peripheral nervous system, ophthalmological studies including optical coherence tomography, lymphoscintigraphy, brain magnetic resonance and nuclear imaging, cerebrospinal fluid hypocretin-1, total tau, phosphorylated tau, amyloid-β1-42 and 14-3-3 proteins measurement, skin, muscular and sural nerve biopsies. Exome and direct sequencing studies disclosed two different point mutations affecting exon 21 of DNMT1 gene in patients with ADCA-DN, a novel heterozygous point mutation in exon 20 in two affected HSAN IE siblings, and a trinucleotide deletion in exon 20 in the latter patient with HSAN IE. Phenotypic characterization pinpoints that ADCA-DN and HSAN IE represent two discrete clinical entities belonging to the same disease spectrum, with variable degree of overlap. Remarkably, narcolepsy with or without cataplexy with low/intermediate or normal cerebrospinal fluid hypocretin-1 is present in both diseases. The human leukocyte antigen DQB1*06:02 was absent in all patients. Other common symptoms and features observed in our cases, involving the central and peripheral nervous system, include deafness, optic neuropathy-previously not reported in HSAN IE-large and small fibres polyneuropathy and lower limbs oedema. Overall, the two syndromes share more characteristics than previously recognized and narcolepsy is common to both. HSAN IE and ADCA-DN are two extreme phenotypic manifestations of a DNMT1 methylopathy. © The Author (2014). Published by Oxford University Press on

  18. La IED en galicia. situación actual y estrategias de futuro

    Directory of Open Access Journals (Sweden)

    Ramos Calvo, Agustín

    2006-01-01

    Full Text Available En este trabajo se trata de apuntar algunos de los posibles factores que pueden estar detrás de la escasa capacidad mostrada por la economía gallega para atraer a la inversión extranjera Directa (IED que se dirigió a España a lo largo del periodo 1993-2002; sugiriendo, además, una serie de medidas para contribuir a corregir ese problema, y reducir las posibles deslocalizaciones empresariales. Para ello se comparan las estructuras productivas y de la IED de España y Galicia, así como la diferencia entre la productividad parcial por trabajador y el coste por trabajador entre todas las CC.AA. españolas; ya que ésta es una de las principales variables que explica la distribución sectorial y regional de la IED en España en el periodo considerado.

  19. An Active Type I-E CRISPR-Cas System Identified in Streptomyces avermitilis

    OpenAIRE

    2016-01-01

    CRISPR-Cas systems, the small RNA-dependent immune systems, are widely distributed in prokaryotes. However, only a small proportion of CRISPR-Cas systems have been identified to be active in bacteria. In this work, a naturally active type I-E CRISPR-Cas system was found in Streptomyces avermitilis. The system shares many common genetic features with the type I-E system of Escherichia coli, and meanwhile shows unique characteristics. It not only degrades plasmid DNA with target protospacers, b...

  20. ANSI/ASHRAE/IES Standard 90.1-2013 Determination of Energy Savings: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Hart, Philip R.; Richman, Eric E.; Athalye, Rahul A.; Winiarski, David W.

    2014-09-04

    This report provides a final qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition). All addenda in creating Standard 90.1-2013 were evaluated for their projected impact on energy efficiency. Each addendum was characterized as having a positive, neutral, or negative impact on overall building energy efficiency.

  1. An Active Type I-E CRISPR-Cas System Identified in Streptomyces avermitilis.

    Science.gov (United States)

    Qiu, Yi; Wang, Shiwei; Chen, Zhi; Guo, Yajie; Song, Yuan

    2016-01-01

    CRISPR-Cas systems, the small RNA-dependent immune systems, are widely distributed in prokaryotes. However, only a small proportion of CRISPR-Cas systems have been identified to be active in bacteria. In this work, a naturally active type I-E CRISPR-Cas system was found in Streptomyces avermitilis. The system shares many common genetic features with the type I-E system of Escherichia coli, and meanwhile shows unique characteristics. It not only degrades plasmid DNA with target protospacers, but also acquires new spacers from the target plasmid DNA. The naive features of spacer acquisition in the type I-E system of S. avermitilis were investigated and a completely conserved PAM 5'-AAG-3' was identified. Spacer acquisition displayed differential strand bias upstream and downstream of the priming spacer, and irregular integrations of new spacers were observed. In addition, introduction of this system into host conferred phage resistance to some extent. This study will give new insights into adaptation mechanism of the type I-E systems in vivo, and meanwhile provide theoretical foundation for applying this system on the genetic modification of S. avermitilis.

  2. An Active Type I-E CRISPR-Cas System Identified in Streptomyces avermitilis.

    Directory of Open Access Journals (Sweden)

    Yi Qiu

    Full Text Available CRISPR-Cas systems, the small RNA-dependent immune systems, are widely distributed in prokaryotes. However, only a small proportion of CRISPR-Cas systems have been identified to be active in bacteria. In this work, a naturally active type I-E CRISPR-Cas system was found in Streptomyces avermitilis. The system shares many common genetic features with the type I-E system of Escherichia coli, and meanwhile shows unique characteristics. It not only degrades plasmid DNA with target protospacers, but also acquires new spacers from the target plasmid DNA. The naive features of spacer acquisition in the type I-E system of S. avermitilis were investigated and a completely conserved PAM 5'-AAG-3' was identified. Spacer acquisition displayed differential strand bias upstream and downstream of the priming spacer, and irregular integrations of new spacers were observed. In addition, introduction of this system into host conferred phage resistance to some extent. This study will give new insights into adaptation mechanism of the type I-E systems in vivo, and meanwhile provide theoretical foundation for applying this system on the genetic modification of S. avermitilis.

  3. Discourse Surrounding the International Education Standards for Professional Accountants (IES): A Content Analysis Approach

    Science.gov (United States)

    Sugahara, Satoshi; Wilson, Rachel

    2013-01-01

    The development and implementation of the International Education Standards (IES) for professional accountants is currently an important issue in accounting education and for educators interested in a shift toward international education standards more broadly. The purpose of this study is to investigate professional and research discourse…

  4. 44 CFR 60.23 - Planning considerations for mudslide (i.e., mudflow)-prone areas.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Planning considerations for... Insurance Program CRITERIA FOR LAND MANAGEMENT AND USE Additional Considerations in Managing Flood-Prone, Mudslide (i.e., Mudflow)-Prone and Flood-Related Erosion-Prone Areas § 60.23 Planning considerations for...

  5. Discourse Surrounding the International Education Standards for Professional Accountants (IES): A Content Analysis Approach

    Science.gov (United States)

    Sugahara, Satoshi; Wilson, Rachel

    2013-01-01

    The development and implementation of the International Education Standards (IES) for professional accountants is currently an important issue in accounting education and for educators interested in a shift toward international education standards more broadly. The purpose of this study is to investigate professional and research discourse…

  6. SCHOOL LIGHTING APPLICATION DATA. EXCERPTS FROM THE IES LIGHTING HANDBOOK, 3RD EDITION.

    Science.gov (United States)

    Illuminating Engineering Society, New York, NY.

    THIS PUBLICATION REGARDING SCHOOL LIGHTING WAS PREPARED AS A USEFUL ADDITION TO THE AMERICAN STANDARD GUIDE FOR SCHOOL LIGHTING. THE MATERIAL HAS BEEN EXTRACTED FROM THE IES LIGHTING HANDBOOK TO INCLUDE A MORE DETAILED TREATMENT OF SUBJECTS TO WHICH THE DESIGNER MUST GIVE IMPORTANT CONSIDERATION. THERE IS A MORE EXTENSIVE TREATMENT OF REFLECTED…

  7. Physics of shock tube simulated IED blast for mTBI research

    NARCIS (Netherlands)

    Mediavilla Varas, J.; Philippens, M.M.G.M.; Meijer, S.R.

    2010-01-01

    The objective of this research is to understand the blast propagation into the human skull and brain causing mTBI and use this knowledge for enabling design of effective protection measures against them. A shock tube including sensor system was optimized to simulate realistic IED blast profiles obta

  8. Game Theory, Adaptation, and Genetic Programming: Some Perspectives on Operations Research for Counter-IED

    Science.gov (United States)

    2011-06-01

    memes” ( Dawkins , 1989; Gabora, 1995; Boal & Schultz, 2007). As Weeks & Galunic (2003) point out: “Memes are the replicators in cultural evolution...Books. Dawkins , R. (1989), The Selfish Gene, 2 nd ed., Oxford University Press. Dekker, A.H. (2010), “Agent-Based Simulation for Counter-IED: A

  9. Physics of shock tube simulated IED blast for mTBI research

    NARCIS (Netherlands)

    Mediavilla Varas, J.; Philippens, M.M.G.M.; Meijer, S.R.

    2010-01-01

    The objective of this research is to understand the blast propagation into the human skull and brain causing mTBI and use this knowledge for enabling design of effective protection measures against them. A shock tube including sensor system was optimized to simulate realistic IED blast profiles

  10. Wood science and conservation: activities and achievements of COST Action IE0601

    OpenAIRE

    Uzielli, Luca; Gril, Joseph

    2012-01-01

    International audience; COST Action IE0601 "Wood Science for Conservation of Cultural Heritage (WoodCultHer)"1 was started in 2007 to promote the science needed for the conservation of wooden cultural heritage. This special issue of Journal of Cultural Heritage being an outcome of that Action, its organisation and activities will be detailed in this introductory paper.

  11. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Hart, Reid; Athalye, Rahul A.; Rosenberg, Michael I.; Richman, Eric E.; Winiarski, David W.

    2014-03-01

    Section 304(b) of the Energy Conservation and Production Act (ECPA), as amended, requires the Secretary of Energy to make a determination each time a revised version of ASHRAE Standard 90.1 is published with respect to whether the revised standard would improve energy efficiency in commercial buildings. When the U.S. Department of Energy (DOE) issues an affirmative determination on Standard 90.1, states are statutorily required to certify within two years that they have reviewed and updated the commercial provisions of their building energy code, with respect to energy efficiency, to meet or exceed the revised standard. This report provides a preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition).

  12. Psychometric properties of the IES-R in traumatized substance dependent individuals with and without PTSD.

    Science.gov (United States)

    Rash, Carla J; Coffey, Scott F; Baschnagel, Joseph S; Drobes, David J; Saladin, Michael E

    2008-08-01

    Posttraumatic stress disorder (PTSD) is common among treatment-seeking substance abusers. Despite the high prevalence of these co-occurring conditions, few PTSD screening tools have been evaluated for their utility in identifying PTSD in substance use disorder (SUD) populations. The present study evaluated the psychometric properties of the Impact of Event Scale-Revised (IES-R) in a sample of 124 substance dependent individuals. All participants had a history of a DSM-IV Criterion A traumatic event, and 71 individuals met diagnostic criteria for PTSD. Participants with comorbid PTSD reported significantly more symptoms of anxiety, depression, and PTSD compared to substance dependent individuals without PTSD. Acceptable internal consistency and convergent validity of the IES-R were established among a substance dependent sample. Examination of diagnostic effectiveness suggested a cutoff value of 22 as optimal for a substance using population, resulting in adequate classification accuracy, sensitivity, and specificity.

  13. Evaluating Light Source Color Rendition using the IES TM-30-15 Method

    Energy Technology Data Exchange (ETDEWEB)

    Houser, Kevin W.; Royer, Michael P.; David, Aurelien

    2015-11-30

    A system for evaluating the color rendition of light sources was recently published as IES TM-30-15 IES Method for Evaluating Light Source Color Rendition. The system includes a fidelity index (Rf) to quantify similarity to a reference illuminant, a relative-gamut index (Rg) to quantify saturation relative to a reference illuminant, and a color vector icon that visually presents information about color rendition. The calculation employs CAM02-UCS and uses a newly-developed set of reflectance functions, comprising 99 color evaluation samples (CES). The CES were down-selected from 105,000 real object samples and are uniformly distributed in color space (fairly representing different colors) and wavelength space (avoiding artificial increase of color rendition values by selective optimization).

  14. A methodology aimed at fostering and sustaining the development processes of an IE-based industry

    Science.gov (United States)

    Corallo, Angelo; Errico, Fabrizio; de Maggio, Marco; Giangreco, Enza

    In the current competitive scenario, where business relationships are fundamental in building successful business models and inter/intra organizational business processes are progressively digitalized, an end-to-end methodology is required that is capable of guiding business networks through the Internetworked Enterprise (IE) paradigm: a new and innovative organizational model able to leverage Internet technologies to perform real-time coordination of intra and inter-firm activities, to create value by offering innovative and personalized products/services and reduce transaction costs. This chapter presents the TEKNE project Methodology of change that guides business networks, by means of a modular and flexible approach, towards the IE techno-organizational paradigm, taking into account the competitive environment of the network and how this environment influences its strategic, organizational and technological levels. Contingency, the business model, enterprise architecture and performance metrics are the key concepts that form the cornerstone of this methodological framework.

  15. Application of Technical and Economic Anatomy(TEA)in Industrial Engineering(IE)

    Institute of Scientific and Technical Information of China (English)

    ZengJianqiu

    1998-01-01

    In this paper,a new method,Technical and Economic Anatomy(TEA),is introduced and further,to discuss its application in industrial Engineering(IE).TEA is a method of after-evaluation which is being used in more and more fields.Feasibility Study(FS).Value Engineering(VE)and Technical and Economic Anatomy(TEA) will be called before-evaluation,Middle-evaluation and after-evaluation in Technical Economics or Engineering Economics.

  16. 让MyIE2独裁所有网页

    Institute of Scientific and Technical Information of China (English)

    StarCraft

    2004-01-01

    MyIE2是很多朋友都在使用的一款多页面浏览器,不过我们在操作本地网页或者打开MSN上好友发过来的地址时,系统常常会调用IE或者QQ浏览器来打开页面,怎样让MyIE掌控所有网页文件呢?

  17. Orifice sizes for K-reactor fringe zones with I&E fuel

    Energy Technology Data Exchange (ETDEWEB)

    Waters, E.D.; Calkin, J.F.

    1960-10-20

    The purpose of this report is to describe orifice combinations which can be utilized in Zone 2, 3, and 4 of the K Reactors while using K-IV I&E fuel elements and to present working data to describe the calibration and.critical flow characteristics of initial prototypes of these orifice combinations. A discussion is included concerning the minimum flow rates attainable by front face orificing while avoiding critical flow conditions.

  18. Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence

    Directory of Open Access Journals (Sweden)

    Khodamorad Jamshidi

    2015-01-01

    Full Text Available Background:   Primary bone lymphoma or non-Hodgkin lymphoma of bone is a rare disease. There are only a few case series of stage IE of this condition in medical literature. The aim of this study is to determine the rate of survival   for stage IE after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     Methods:   We collected data from 61 patients with histologically confirmed PBL treated at the Musculoskeletal   Oncology Department of our hospital from 2000 to 2010. Retrospective evaluation included demographics, symptoms, tumor locations, outcomes of surgical treatment for local recurrence and survival rates. Results:   All patients received Combined Modality Therapy. Overall,five year survival was 89% and five year disease free survival rate was 78%. Local recurrence occurred in 6 patients during follow up period, which was treated surgically     by wide excision and reconstruction. The mean follow-up for the local recurrence group was 36(24-54 months and mortality rate in this group was 17%. Conclusions:   Combined Modality Therapy for stage IE primary bone lymphomaresults in good survival rate. In case   of local recurrence, wide excision and reconstruction improves the outcomes.

  19. Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence

    Directory of Open Access Journals (Sweden)

    Khodamorad Jamshidi

    2015-01-01

    Full Text Available Background:   Primary bone lymphoma or non-Hodgkin lymphoma of bone is a rare disease. There are only a few case series of stage IE of this condition in medical literature. The aim of this study is to determine the rate of survival   for stage IE after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     Methods:   We collected data from 61 patients with histologically confirmed PBL treated at the Musculoskeletal   Oncology Department of our hospital from 2000 to 2010. Retrospective evaluation included demographics, symptoms, tumor locations, outcomes of surgical treatment for local recurrence and survival rates. Results:   All patients received Combined Modality Therapy. Overall,five year survival was 89% and five year disease free survival rate was 78%. Local recurrence occurred in 6 patients during follow up period, which was treated surgically     by wide excision and reconstruction. The mean follow-up for the local recurrence group was 36(24-54 months and mortality rate in this group was 17%. Conclusions:   Combined Modality Therapy for stage IE primary bone lymphomaresults in good survival rate. In case   of local recurrence, wide excision and reconstruction improves the outcomes.

  20. Noise and Vibration Monitoring for Premium Efficiency IE 3 Three-Phase Induction Motors

    Directory of Open Access Journals (Sweden)

    NISTOR, C. G.

    2015-08-01

    Full Text Available The paper presents the original SV-100 platform that enables low-cost and very high accuracy determinations of noise and vibration levels. The aim of the proposed platform is to achieve an effective integration of the two topics of this analysis: vibrations and noises. To the best of our knowledge, no low price, dedicated compact platform with embedded measuring instruments exists. For proving the practical utility of the proposed platform, two induction motors of 7.5 kW and 11 kW, respectively, in single-layer winding, at 1000 rpm, with IE3 premium efficiency were analyzed. This analysis is required because, according to IEC60034-30 standard, the IE3 efficiency standard has become mandatory for induction motors of rated power greater than 7.5 kW. Therefore, in order to improve the motor operating efficiency, the power losses caused by noises and vibrations have to be reduced. Several variants of supply were studied, i.e., by the three-phase 50 Hz network and by a three-phase inverter at 40, 50 and 60 Hz, respectively. The experimental determinations of noises are presented comparatively, by using a Bruel&Kjaer sonometer and by using the new platform SV-100. The results are compared with the IEC60034 standard.

  1. The RDB: A parallel, spatial database for the IES/BTI system

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, K.; Winter, L.

    1995-04-01

    The manipulation and representation of spatial data on computers is an important issue in many computer applications. Spatial data, which consists of points, lines, and regions in 2-dimensions, can be difficult to manage efficiently because it is often quite voluminous. For instance, the number of picture elements in even a small digital image is on the order of a million, while the number of locations stored in a terrain database can easily include billions of points. Furthermore, the kinds of operations performed on spatial data -- set operations, insertion, deletion, searches such as ``near`` -- are compute intensive, and hence slow unless the data is structured to reflect its underlying topology. Hence a conventional database which is organized on search keys is often not adequate for handling spatial data. The Image Exploitation System, which is an automated image analysis system, has a great need for efficient storage and manipulation of spatial data. The Image Exploitation System is part of the Advanced Research Project Agency`s Balanced Technology Initiative and is abbreviated IES/BTI. IES/BTI must process tens to hundreds of megabytes of imagery in a few minutes, and is composed of many independent components which need to access and share spatial data. The system needed an efficient parallel spatial database, hence the motivation for our work on the Region Database, or RDB. The RDB is our attempt to meet the needs of the IES/BTI Cycle 2 system. The RDB provides for storage and retrieval of both raster and vector based spatial data as well as attribute-based retrievals. It also provides facilities for conversion between the two representations of spatial data (raster and vector) and for efficient, parallel boolean operations on vector data. In this paper we discuss the research and development performed to design and implement the RDB.

  2. AGITATION AND MASS FORMS OF ART IN THE 20-IES OF THE XX CENTURY IN RUSSIA

    OpenAIRE

    2016-01-01

    The article deals with the forms of agitation and mass art, the creation of which was authorized by the Bolsheviks in the 20ies of the XX century for effective advocacy activities. It is noted, that agitation and mass art is one of the most important and effective means of policies and has played a huge role in the establishment of Soviet power. Propaganda direction was manifested in the both of drawing and painting and was aimed at the formation of a new proletarian thinking in a socialist s...

  3. Evaluation of ANSI/ASHRAE/USGBC/IES Standard 189.1-2009

    Energy Technology Data Exchange (ETDEWEB)

    Long, N.; Bonnema, E.; Field, K.; Torcellini, P.

    2010-07-01

    The National Renewable Energy Laboratory (NREL) evaluated ANSI/ASHRAE/USGBC/IES Standard 189.1-2009, 'The Standard for High-Performance Green Buildings Except Low-Rise Residential Buildings'. NREL performed this evaluation by examining the results of predictions for site energy use from a comprehensive set of EnergyPlus models. NREL has conducted an 'order-of-magnitude' analysis in this study to identify the likely overall impact of adopting Standard 189.1-2009 over ANSI/ASHRAE/IESNA Standard 90.1-2007.

  4. Memoria Prácticas Aula de Convivencia IES Francesc Ribalta

    OpenAIRE

    Llorens Ribes, Marcos

    2013-01-01

    Treball de Fi de Màster Universitari en Intervenció i Mediació Familiar . Curs 2012/2013 El presente trabajo, versa alrededor de la estancia realizada en el aula de convivencia del IES Francesc Ribalta en la ciudad de Castelló de la Plana. Las aulas de convivencia, surjen a partir del decreto 39/2008,de 4 de abril, del Consell, sobre la convivencia en los centros docentes no universitarios sostenidos con fondos públicos y sobre los derechos y deberes del alumnado, padres, madres, tutore...

  5. CONSIDERAŢII PRIVIND IMPORTANŢA METODEI DE CALCULAŢIE A COSTULUI PE COMENZI

    Directory of Open Access Journals (Sweden)

    Svetlana MIHAILA

    2016-12-01

    Full Text Available În acest articol este prezentată o modalitate de organizare a contabilităţii de gestiune şi a calculaţiei costurilor prin metoda pe comenzi. Sunt tratate etapele de derulare a metodei de calculaţie a costului pe comenzi, respectiv rolul conta­bilului de gestiune în derularea şi implementarea acestei metode. Din punct de vedere teoretic şi aplicativ, sunt abordate etapele metodologice parcurse în contabilitatea de gestiune şi calculaţia costurilor.Concluziile formulate vizează organizarea contabilităţii de gestiune; entitatea trebuie să aplice cea mai eficientă metodă de calculaţie, ba chiar şi o combinaţie de metode de calculaţie – clasice şi moderne, în concordanţă cu parti­cularităţile tehnologiei şi organizării producţiei, precum şi cu cerinţele unei administrări eficiente. Totodată, sunt abor­date şi avantajele pe care le oferă metoda pe comenzi, de unde derivă şi importanţa acestui subiect. CONSIDERATIONS ON THE IMPORTANCE OF THE JOB-ORDER COSTING SYSTEM The authors present a method for the organization of the management accounting and job-order costing. Consideration has been given to the stages of the job-order costing system, as well as to the role of the accountant in the application and implementation of such method. The authors have adopted a theoretical and applicative approach in regard to the methodological stages covered by the management accounting and the costing method.The article ends with the authors' conclusions regarding the organization of the management accounting. In this respect, it outcomes that an entity is to apply the most efficient costing method and, moreover, a combination of classical and modern costing methods, in accordance with the specific features of the manufacturing process and production engineering, as well as the efficient management requirements. The authors have also shed light on the advantages offered by the job-order costing system, and the resulting

  6. AGITATION AND MASS FORMS OF ART IN THE 20-IES OF THE XX CENTURY IN RUSSIA

    Directory of Open Access Journals (Sweden)

    Bochkareva A. S.

    2016-09-01

    Full Text Available The article deals with the forms of agitation and mass art, the creation of which was authorized by the Bolsheviks in the 20ies of the XX century for effective advocacy activities. It is noted, that agitation and mass art is one of the most important and effective means of policies and has played a huge role in the establishment of Soviet power. Propaganda direction was manifested in the both of drawing and painting and was aimed at the formation of a new proletarian thinking in a socialist society. It is stated, that the content of works of art is determined, above all, by the military-political situation that prevailed in the 20-ies. It is shown, that in the works of art displayed figures of the new revolutionary themes, events and characters, but also significant presence of the image of the new man - working men and women, sailors, soldiers, peasants was traced. Festive decoration of cities and towns, from the capital to the smallest provincial towns was filled with agitation and propaganda content. The conclusion is that artistic and political design of squares, streets, public buildings should help to create a festive mood, increase employment, ideological and socio-political activity of the workers. In general, new forms of agitation and propaganda were created through art, by turning the novelty of content, depth of the emotional impact, thematic literacy and specificity for the necessary psychological mood of society during the study period

  7. IE6也支持标签浏览

    Institute of Scientific and Technical Information of China (English)

    白玉京

    2007-01-01

    有没有办法让IE6也支持多标签浏览呢?免费小插件Windowst,iveToolbar(以3.1.0.130版为例,下载地址:http://toolbar.Ijve.com/?mkt=zh=cn)就可以实现。安装WindowsLiveToolbar后重新启动IE6,就可以看见windowsLiveToolbar搜索框下新增加的标签以及其相应的功能按钮。点击左侧功能按钮的“+”号图标可以新增加标签,标签的样式和排列类似我们熟悉的傲游(Maxthon)浏览器,在不同标签中可以通过鼠标点击快速切换(如图)。

  8. Ocular injuries in survivors of improvised explosive devices (IED in commuter trains

    Directory of Open Access Journals (Sweden)

    Agarwal Vinay

    2007-09-01

    Full Text Available Abstract Background Ocular injuries are common in survivors of terror incidents that involve the use of explosive materials. These explosives are commonly of a High Explosive type (HE and may be fashioned into improvised explosive devices (IED that incorporate additional materials to maximise trauma and injuries. Serial IED explosions have occurred in commuter trains in several cities including London and Madrid but data on ocular injuries is limited. We report the ocular injuries of the survivors of a series of IED explosions in crowded commuter trains. Methods 28 patients (56 eyes, 28 male, ages ranging from 22 to 52 years (mean 35.27 years were screened in the triage area or the Intensive Care Unit (ICU. Testing included bedside visual acuity testing, torchlight examination of the anterior segment and dilated (or if necessary, undilated fundus examination. Selected patients underwent B-scan examination, magnetic resonance imaging of the brain, orbits and the optic nerves or visual evoked potential assessment. The injuries, investigations and procedures were entered into the patient's case sheet as well as into a standardised format suggested by the Indian eye injury registry (IER. Results 16 of 28 patients (57.1% had ocular injuries whereas 12 (42.8% were found to be normal. Injuries were seen unilaterally in 10 patients and bilaterally in six yielding a total of 22 injured eyes. The common injuries were periorbital haemorrhages (09 eyes, 40%; first or second degree burns to the upper or lower lids (seen in 07 eyes, 31.8 % and corneal injuries (seen in 08 eyes, 36.3%. Open globe injuries were seen in two eyes of two patients (09%. One patient (4.5% had a traumatic optic neuropathy. Conclusion Ophthalmologists and traumatologists should be aware of these patterns of ocular injuries. Protocols need to include the screening of large numbers of patients in a short time, diagnostic tests (B scan, visual evoked potential (VEP etc and early surgery

  9. Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system.

    Science.gov (United States)

    Kiro, Ruth; Shitrit, Dror; Qimron, Udi

    2014-01-01

    The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) system has recently been used to engineer genomes of various organisms, but surprisingly, not those of bacteriophages (phages). Here we present a method to genetically engineer the Escherichia coli phage T7 using the type I-E CRISPR-Cas system. T7 phage genome is edited by homologous recombination with a DNA sequence flanked by sequences homologous to the desired location. Non-edited genomes are targeted by the CRISPR-Cas system, thus enabling isolation of the desired recombinant phages. This method broadens CRISPR Cas-based editing to phages and uses a CRISPR-Cas type other than type II. The method may be adjusted to genetically engineer any bacteriophage genome.

  10. CARACTERE SPECIFICE VINOVĂŢIEI – CONDIŢIE A RĂSPUNDERII JURIDICE CIVILE

    Directory of Open Access Journals (Sweden)

    Eugenia COJOCARI

    2015-11-01

    Full Text Available În acest articol autorii şi-au propus scopul să analizeze particularităţile caracterelor specifice vinovăţiei – condiţie a răspunderii juridice civile în ambele ei forme din cadrul dreptului civil, pentru a determina rolul şi importanţa acesteia în aplicarea răspunderii civile şi repararea prejudiciului. Pentru realizarea acestui scop şi determinarea rolului, importanţei şi particularităţilor caracterelor specifice ale vinovăţiei din dreptul civil, autorii au analizat legislaţia în vigoare a Republicii Moldova, a altor state, precum şi doctrina. Ei au caracterizat noţiunea de vinovăţie, caracterele ei specifice, propunând o definiţie proprie, specificul căreia constă în faptul că apare şi ca noţiune de culpă, greşală, prin care se subînţelege atitu-dinea persoanei faţă de fapta săvârşită, toate având un caracter subiectiv. Sunt evidenţiate şi analizate următoarele caractere specifice vinovăţiei civile: intelectiv, volitiv, exterioritiv. Pentru a formula unele concluzii şi recomandări proprii, autorii au analizat în aspect de drept comparat Codul civil al Republicii Moldova, ale altor state cu referire la subiect, precum şi doctrina. În rezultatul cercetărilor efectuate sunt formulate concluzii şi înaintate recomandări, principala fiind că vino-văţia – condiţie a răspunderii juridice civile – este nu doar necesară, dar ar fi bine ca la aplicarea răspunderii juridice civile, la determinarea valorii prejudiciului cauzat să se ţină cont de formele şi de gradele acesteia, aşa ca în dreptul penal.SPECIFIC CHARACTERS GUILT – CONDITION OF LIABILITY CIVIL LEGALIn this article the authors aimed to analyze the peculiarities of specific characters guilt - condition of civil liability in both its forms of civil law to determine the role and importance in the application of liability and compensation. In achieving this goal and determining the role, importance and

  11. ANSI/ASHRAE/IES Standard 90.1-2016 Performance Rating Method Reference Manual

    Energy Technology Data Exchange (ETDEWEB)

    Goel, Supriya; Rosenberg, Michael I.; Eley, Charles

    2017-09-29

    This document is intended to be a reference manual for the Appendix G Performance Rating Method (PRM) of ANSI/ASHRAE/IES Standard 90.1-2016 (Standard 90.1-2016). The PRM can be used to demonstrate compliance with the standard and to rate the energy efficiency of commercial and high-rise residential buildings with designs that exceed the requirements of Standard 90.1. Use of the PRM for demonstrating compliance with Standard 90.1 is a new feature of the 2016 edition. The procedures and processes described in this manual are designed to provide consistency and accuracy by filling in gaps and providing additional details needed by users of the PRM.

  12. Low-cost detection of RC-IED activation signals in VHF band

    Science.gov (United States)

    Camargo Suarez, Victor Hugo; Marulanda B., Jose Ignacio

    2014-05-01

    The proliferation of Radio Controlled Improvised Explosive Devices (RC-IED) is a growing threat around the world. The ease of construction and low cost of these devices are transforming common things in lethal tramps. The fight against this threats normally involves the use of sophisticated and expensive equipment of Electronic Warfare based on high speed DSP systems, just to detect the presence of detonation signals. In this work is showed how to find activation signals based on the characteristic of the power in a specific band and the previous knowledge about the detonation signals. As proof of concept we have taken the information about the RC-IEDs used in the Colombian conflict and develop an algorithm to find detonation signals based on the measured power in frequencies between 136 MHz and 174 MHz (2 meter civil band)

  13. ANSI/ASHRAE/IES Standard 90.1-2013 Determination of Energy Savings: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Athalye, Rahul A.; Rosenberg, Michael I.; Xie, YuLong; Wang, Weimin; Hart, Philip R.; Zhang, Jian; Goel, Supriya; Mendon, Vrushali V.

    2014-09-04

    This report provides a final quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in improved energy efficiency in commercial buildings. The final analysis considered each of the 110 addenda to Standard 90.1-2010 that were included in Standard 90.1-2013. PNNL reviewed all addenda included by ASHRAE in creating Standard 90.1-2013 from Standard 90.1-2010, and considered their combined impact on a suite of prototype building models across all U.S. climate zones. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE’s final determination. However, out of the 110 total addenda, 30 were identified as having a measureable and quantifiable impact.

  14. Narečie postepeno kak leksičeskij kvantifikator

    Directory of Open Access Journals (Sweden)

    Ristić Stana

    2008-01-01

    Full Text Available (ruski V rabote na osnove analiza primerov upotreblenija narečija postepeno vyjavljajutsja ego obščie harakteristiki i opredeljajutsja grammatičesko-semantičeskie uslovija realizacii ego značenija i funkcii. Narečie postepeno otneseno k polnost'ju pragmatičeskim kvantifikatoram partitivno-distributivnogo tipa, pri ëtom ego partitivnost' organizovana v sootvetstvii s kriteriem vremennój linearnosti. Svojstva partitivnosti distributivnosti i sukcessivnosti, vyražennye u narečija postepeno predstavljajut soboj ingerentnuju harakteristiku složnoj situacii, kotoraja zapolnjaet semantičeskuju valentnost' dannogo odnomestnogo predikata. Rasčlenennost' složnoj situacii, kak neobhodimoe uslovie upotreblenija dannogo narečija, možet byt' realizovana v vide predikativnogo soderžanija i / ili v vide soderžanija argumentov predikata. Vozmožnost' zapolnenija semantičeskoj i sintaksičeskoj valentnosti predikata i / ili semantičeskoj valentnosti ego argumentov osuščestvljaetsja na osnove semantičeskih pravil dvuh tipov, kotorymi opredeljaetsja sfera dejstvija netrivial'nyh značenij narečija postepeno i ego grammatičesko-semantičeskaja sočetaemost'. Različnye grammatičesko-semantičeskie uslovija realizacii ego značenija i funkcii vyjavlennye v rabote, predstavleny v prilagaemoj tablice kak varianty osnovnyh tipov, obuslovlennyh obščimi grammatičeskimi imennymi i glagol'nymi kategorijami, takimi, kak množestvennost' / sobiratel'nost', edinstvennoe čislo i nesoveršennyj vid, soveršennyj vid.

  15. The Slavery in Circassia and the United States (1850–1860-ies years: General and Special

    Directory of Open Access Journals (Sweden)

    Mikhal Smigel

    2016-12-01

    Full Text Available The article provides a comparative analysis of slavery in Circassia and in the territory of the slave South in the United States in 1850–1860-ies years in the context of the fight against the slave trade and slavery in the world. The article discusses the Russian-American general trends for the prohibition of slavery and the slave trade. Among the materials are Russian and foreign archival sources, documents of personal origin (memoirs, diaries of travelers as well as scientific research. The methodological basis of historical-comparative study are the principles of objectivity and historicism, suggesting an unbiased approach to the analysis of the studied problems, a critical attitude to the sources, making judgments as a result of the analysis of a set of facts, and displays the slave of phenomena in the development and the context of the historical situation. In conclusion, the authors note that slavery and the slave position in the United States and the Circassia had their differences in 1850–1860-ies. Such differences included the inability of the transition to the United States from the status of a slave in the state of the dependent peasant, which was the norm in Circassia. In the United States the slaves were brought from outside, while in Circassia the slavery occurred in the region, mainly by trapping. At the root of discrimination in the United States was the racial principle, in Circassia this is based on the religious principle. The position of slaves had their similarities. A slave was powerless property of his master, there were certain unwritten rules governing the relationship, slave owners were reluctant to bring slaves to the extreme and etc. The important similarity between the US and Circassia was the presence of their territories with a strong slave system, where slaves constituted more than 30 % of the population. In the US, it was the territory of the slave-holding South, and in Circassia – the slaveholding Ubykhia.

  16. FORMATION OF PERIODICALS IN KHANTYMANSI AUTONOMOUS DISTRICT IN THE 1930-1950-IES

    Directory of Open Access Journals (Sweden)

    N. S. Kharina

    2015-01-01

    Full Text Available This article considers periodicals organizing and management on the territory of Khanty-Mansi Autonomous District at period of 1930-50-ies. The study of periodicals is one of the most important aspects in historical science. At the time of the Soviet Union the press was considered as an important part of ideological work. The study is actual due to lack of general and complex research on that subject. We employed historic, problematic chronological, analytical and statistic comparative methods during the research. The combined use of all methods allows to reveal regional specifics and peculiarities. At the end of study authors concludes that periodicals have dual function: to inform contemporaries about reality and to form an idea of it. This is implemented in every issue through the selection of materials and the attracting of the reader’s attention to various publications. Editions of district and regional newspapers were organs of the Party committees and local Soviets VKP and implemented locally the state policy, mobilized the population in the proclamation of the state goals, and all printed information was the information filtered by editors. The majority of active authors of 1930 – 1960-ies consisted of communist party members. Subject-matters of all newspapers issued on the territory of the District throughout the studied period, varied in accordance with the requirements of the time. Regional newspapers showed the practical implementation of all major economic and political plans on concrete examples and facts, talked about the advanced workers of socialist competition and promoted the best organization of production method ensuring the rise of labor productivity. This article has an attempt to examine the organization of periodicals and their administration of the territory of Khanty-Mansi Autonomous District in 1930-1950s. The work is actual due to lack of general and complex research on that subject. The study used historical

  17. Risk assessment methodology applied to counter IED research & development portfolio prioritization

    Energy Technology Data Exchange (ETDEWEB)

    Shevitz, Daniel W [Los Alamos National Laboratory; O' Brien, David A [Los Alamos National Laboratory; Zerkle, David K [Los Alamos National Laboratory; Key, Brian P [Los Alamos National Laboratory; Chavez, Gregory M [Los Alamos National Laboratory

    2009-01-01

    In an effort to protect the United States from the ever increasing threat of domestic terrorism, the Department of Homeland Security, Science and Technology Directorate (DHS S&T), has significantly increased research activities to counter the terrorist use of explosives. More over, DHS S&T has established a robust Counter-Improvised Explosive Device (C-IED) Program to Deter, Predict, Detect, Defeat, and Mitigate this imminent threat to the Homeland. The DHS S&T portfolio is complicated and changing. In order to provide the ''best answer'' for the available resources, DHS S&T would like some ''risk based'' process for making funding decisions. There is a definite need for a methodology to compare very different types of technologies on a common basis. A methodology was developed that allows users to evaluate a new ''quad chart'' and rank it, compared to all other quad charts across S&T divisions. It couples a logic model with an evidential reasoning model using an Excel spreadsheet containing weights of the subjective merits of different technologies. The methodology produces an Excel spreadsheet containing the aggregate rankings of the different technologies. It uses Extensible Logic Modeling (ELM) for logic models combined with LANL software called INFTree for evidential reasoning.

  18. ANSI/ASHRAE/IES Standard 90.1-2010 Performance Rating Method Reference Manual

    Energy Technology Data Exchange (ETDEWEB)

    Goel, Supriya [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-05-01

    This document is intended to be a reference manual for the Appendix G Performance Rating Method (PRM) of ANSI/ASHRAE/IES Standard 90.1- 2010 (Standard 90.1-2010).The PRM is used for rating the energy efficiency of commercial and high-rise residential buildings with designs that exceed the requirements of Standard 90.1. The procedures and processes described in this manual are designed to provide consistency and accuracy by filling in gaps and providing additional details needed by users of the PRM. It should be noted that this document is created independently from ASHRAE and SSPC 90.1 and is not sanctioned nor approved by either of those entities . Potential users of this manual include energy modelers, software developers and implementers of “beyond code” energy programs. Energy modelers using ASHRAE Standard 90.1-2010 for beyond code programs can use this document as a reference manual for interpreting requirements of the Performance Rating method. Software developers, developing tools for automated creation of the baseline model can use this reference manual as a guideline for developing the rules for the baseline model.

  19. The Personnel of the Russian Army in the Caucasus in 1830–1840-ies

    Directory of Open Access Journals (Sweden)

    Vladimir B. Karataev

    2016-09-01

    Full Text Available The article presents the personnel structure of the Russian army in the Caucasus in the period of 1830-1840-ies. The attention is paid to the problems of recruitment, and the study of everyday service of soldiers and officers. There are used the materials of the regional and local archives, namely the State archive of the Krasnodar Krai and the Archival department of administration of Sochi city (Russian Federation, as well as sources of a personal origin (memoirs. The work is widely used the pre-revolutionary, soviet and modern russian literature. The study methods are the principles of objectivity, historicism, systematic, integrated consideration of socio-subjective in the subject of study. In conclusion, the authors note that despite of the difficulties of manning the army units in the Caucasus (the flight of the soldiers, crimes, etc. the military situation and competent management of units, and equally significant terms of service allowed to melt antisocial composition of the number of recruits into combat-ready joint. Russian officers played a significant role in the training and re-recruiting of the masses.

  20. INFRACŢIUNEA ÎN NOUA LEGISLAŢIE PENALĂ A ROMÂNIEI

    Directory of Open Access Journals (Sweden)

    Cosmin-Vasile AMBROSĂ

    2016-03-01

    Full Text Available Noul Cod penal reprezintă un pas important pentru legislaţia penală a României. Prin prevederile sale legiuitorul a încercat să modifice structura infracţiunii, renunţând la forma tradiţională prevăzută de Codul penal din 1968.Această nouă definiţie este una inovativă şi modernă, în concordanţă cu legislaţia penală europeană prin însăşi modi­ficarea structurii acesteia. NEW LEGISLATION CRIMINAL OFFENSE IN ROMNIAThe new Romanian Penal Code is a very important step in Romanian criminal legislation. With its provisions, the Romanian legislator attempted to change the design, abandoning traditional solutions contained in the Criminal Code of 1968.The new definition of the offense, although it was wanted to be one innovative and modern, in accordance to criminal laws of other European countries by changing the design of its structure.

  1. Irradiation Effects Test Series: Test IE-2. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Allison, C. M.; Croucher, D. W.; Ploger, S. A.; Mehner, A. S.

    1977-08-01

    The report describes the results of a test using four 0.97-m long PWR-type fuel rods with differences in diametral gap and cladding irradiation. The objective of this test was to provide information about the effects of these differences on fuel rod behavior during quasi-equilibrium and film boiling operation. The fuel rods were subjected to a series of preconditioning power cycles of less than 30 kW/m. Rod powers were then increased to 68 kW/m at a coolant mass flux of 4900 kg/s-m/sup 2/. After one hour at 68 kW/m, a power-cooling-mismatch sequence was initiated by a flow reduction at constant power. At a flow of 2550 kg/s-m/sup 2/, the onset of film boiling occurred on one rod, Rod IE-011. An additional flow reduction to 2245 kg/s-m/sup 2/ caused the onset of film boiling on the remaining three rods. Data are presented on the behavior of fuel rods during quasiequilibrium and during film boiling operation. The effects of initial gap size, cladding irradiation, rod power cycling, a rapid power increase, and sustained film boiling are discussed. These discussions are based on measured test data, preliminary postirradiation examination results, and comparisons of results with FRAP-T3 computer model calculations.

  2. Social Engineering: I-E based Model of Human Weakness for Attack and Defense Investigations

    Directory of Open Access Journals (Sweden)

    Wenjun Fan

    2017-01-01

    Full Text Available Social engineering is the attack aimed to manipulate dupe to divulge sensitive information or take actions to help the adversary bypass the secure perimeter in front of the information-related resources so that the attacking goals can be completed. Though there are a number of security tools, such as firewalls and intrusion detection systems which are used to protect machines from being attacked, widely accepted mechanism to prevent dupe from fraud is lacking. However, the human element is often the weakest link of an information security chain, especially, in a human-centered environment. In this paper, we reveal that the human psychological weaknesses result in the main vulnerabilities that can be exploited by social engineering attacks. Also, we capture two essential levels, internal characteristics of human nature and external circumstance influences, to explore the root cause of the human weaknesses. We unveil that the internal characteristics of human nature can be converted into weaknesses by external circumstance influences. So, we propose the I-E based model of human weakness for social engineering investigation. Based on this model, we analyzed the vulnerabilities exploited by different techniques of social engineering, and also, we conclude several defense approaches to fix the human weaknesses. This work can help the security researchers to gain insights into social engineering from a different perspective, and in particular, enhance the current and future research on social engineering defense mechanisms.

  3. Le parole etrusche ame, amce e la revisione di IE. *yem- ‘paaren’

    Directory of Open Access Journals (Sweden)

    Adolfo Zavaroni

    2001-12-01

    Full Text Available The main purpose of this article is to demonstrate the groundlessness of the old and common thesis according to which Etr. ame, amuke, amce are parts of the verb “to be”. We can search for the true meaning of these words with the help of the so-called “comparative method”, a method that, in the last few decades, did not enjoy its due share of attention. My underlying thesis is that Etruscan, although not being an Indo-European language, has many IndoEuropean stems, which it acquired during many centuries of contacts. The comparative method might be of help just provided we strictly stick to the rules that define the phonological system of Etruscan (in the present work I present the system of the stops only. The term am(uce indicates ‘to be united, to make a pair with, co-’. In fact, amce is mainly found in connection with the words puia ‘wife’ and zilaθ (magistracy constituted by two or more persons. In extant inscriptions, we also find twice the word ame connected to puia, yet in most cases ame is a particle placed after the verb, where it fulfills the same function of the latin preverb cum, co-. As an example, in the Tabula Cortonensis the words eprus ame mean ‘co-operantur, (they sacrifice together’. Moreover, there are five occurrences of the particle ama connected with the word ipa. In my view, ipa … ama can be interpreted as ‘simul… cum’ = ‘pariter… cum’. There are further Etruscan words beginning with *am -that belong to the same root of ame, am(uce. See for example amθuras, amaνunice, amnu, aminθ. There is also a personage represented in several engravings on mirrors the name of whom is amuke, which is said to echo Greek Αμυκος. Nonetheless, amuke has indeed an Etruscan meaning. In order to explain such Germanic words as Got. ibns ‘eben’, Ags. efn, emn etc. and Lat. imitor, aemulus etc. the I-E root *yem- ‘paaren; to pair, match, couple’ was assumed. Anyhow, it can be smoothly replaced

  4. Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication

    Energy Technology Data Exchange (ETDEWEB)

    Khalil, Mohamed I., E-mail: mkhalil2@stanford.edu [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States); Department of Molecular Biology, National Research Centre, El-Buhouth St., Cairo (Egypt); Che, Xibing; Sung, Phillip; Sommer, Marvin H. [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States); Hay, John [Department of Microbiology and Immunology, School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY (United States); Arvin, Ann M. [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States)

    2016-05-15

    VZV IE62 is an essential, immediate-early, tegument protein and consists of five domains. We generated recombinant viruses carrying mutations in the first three IE62 domains and tested their influence on VZV replication kinetics. The mutations in domain I did not affect replication kinetics while domain II mutations, disrupting the DNA binding and dimerization domain (DBD), were lethal for VZV replication. Mutations in domain III of the nuclear localization signal (NLS) and the two phosphorylation sites S686A/S722A resulted in slower growth in early and late infection respectively and were associated with IE62 accumulation in the cytoplasm and nucleus respectively. This study mapped the functional domains of IE62 in context of viral infection, indicating that DNA binding and dimerization domain is essential for VZV replication. In addition, the correct localization of IE62, whether nuclear or cytoplasmic, at different points in the viral life cycle, is important for normal progression of VZV replication. - Highlights: • Mutation of IE62 domain I did not affect VZV replication in melanoma cells. • IE62 domain II and III are important for VZV replication in melanoma cells. • Mutations of IE62 domain II (DBD) were lethal for virus replication. • Mutations of IE62 NLS and phosphorylation sites inhibited VZV replication. • NLS and S686A/S722A mutations altered localization of IE62 during early and late infection.

  5. KOMPONEN WEB DATA ANALYZER PADA IE STUDI KASUS: AKSES WEB TERFAVORIT LABORATORIUM IBS TEKNIK INFORMATIKA - ITS

    Directory of Open Access Journals (Sweden)

    Darlis Heru Murti

    2005-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Perkembangan dunia internet baik dari segi teknologi maupun jumlah pengguna yang mengakses kian lama semakin bertambah. Hal ini juga berdampak dengan munculnya berbagai situs internet yang menawarkan berbagai hal serta tujuan yang berbeda. Untuk mengakses situs-situs tersebut diperlukan suatu alat yang disebut browser. Salah satu browser yang paling terkenal dan banyak digunakan saat ini adalah Microsoft Internet Explorer (IE. Kalau diperhatikan sebenarnya browser Internet Explorer telah menyediakan fitur khusus bernama Favorites (dapat diakses melalui menu atau toolbar untuk mencatat dan mengorganisasi web-web yang menjadi favorit user. Tetapi fitur Favorites ini kurang fleksibel karena pemasukan data maupun pengorganisasiannya masih bersifat manual oleh user. Untuk itu perlu diimplementasikan perangkat lunak dengan fitur Favorites yang bersifat otomatis dan dinamis sehingga untuk periode waktu maupun lokasi akses workstation tertentu bisa memiliki informasi favorit website yang berbeda-beda. Sebagai solusi yang dapat digunakan adalah dengan memanfaatkan teknologi rekayasa perangkat lunak yaitu pembuatan komponen yang melekat pada browser Internet Explorer atau lebih dikenal dengan istilah plugin Internet

  6. Ideologi Keluarga Tradisional “IE “ dan Kazoku Kokka pada Masyarakat Jepang Sebelum dan Sesudah Perang Dunia II

    Directory of Open Access Journals (Sweden)

    Etty N. Anwar

    2007-10-01

    Full Text Available In studying Japan’s cultural institution, understanding IE, which was the traditional family system used by the Bushi in the Tokugawa era, is indispensable. The IE system is believed to influence the entire aspect of Japanese life, be it the way of thinking, politics, social, economy, marriage, religion, and even the view of “Family State” in the era of Meiji Restoration implemented the structure of IE system. Hence, the IE system is considered to be one of the pillars of Japan’s success. This short essay will discuss the IE ideology in the concept of experts on Japanese culture, the principles of Japanese’s social relationships, the IE ideology in the structure of “Family State”, and Japan’s modern family system.

  7. Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper Functioning.

    Directory of Open Access Journals (Sweden)

    Hsuan Tung

    Full Text Available Baculoviruses have gained popularity as pest control agents and for protein production in insect systems. These viruses are also becoming popular for gene expression, tissue engineering and gene therapy in mammalian systems. Baculovirus infection triggers a heat shock response, and this response is crucial for its successful infection of host insect cells. However, the viral protein(s or factor(s that trigger this response are not yet clear. Previously, we revealed that IE2-an early gene product of the baculovirus-could form unique nuclear bodies for the strong trans-activation of various promoters in mammalian cells. Here, we purified IE2 nuclear bodies from Vero E6 cells and investigated the associated proteins by using mass spectrometry. Heat shock proteins (HSPs were found to be one of the major IE2-associated proteins. Our experiments show that HSPs are greatly induced by IE2 and are crucial for the trans-activation function of IE2. Interestingly, blocking both heat shock protein expression and the proteasome pathway preserved the IE2 protein and its nuclear body structure, and revived its function. These observations reveal that HSPs do not function directly to assist the formation of the nuclear body structure, but may rather protect IE2 from proteasome degradation. Aside from functional studies in mammalian cells, we also show that HSPs were stimulated and required to determine IE2 protein levels, in insect cells infected with baculovirus. Upon inhibiting the expression of heat shock proteins, baculovirus IE2 was substantially suppressed, resulting in a significantly suppressed viral titer. Thus, we demonstrate a unique feature in that IE2 can function in both insect and non-host mammalian cells to stimulate HSPs, which may be associated with IE2 stabilization and lead to the protection of the its strong gene activation function in mammalian cells. On the other hand, during viral infection in insect cells, IE2 could also strongly

  8. Differential effects of Sp cellular transcription factors on viral promoter activation by varicella-zoster virus (VZV) IE62 protein.

    Science.gov (United States)

    Khalil, Mohamed I; Ruyechan, William T; Hay, John; Arvin, Ann

    2015-11-01

    The immediate early (IE) 62 protein is the major varicella-zoster virus (VZV) regulatory factor. Analysis of the VZV genome revealed 40 predicted GC-rich boxes within 36 promoters. We examined effects of ectopic expression of Sp1-Sp4 on IE62- mediated transactivation of three viral promoters. Ectopic expression of Sp3 and Sp4 enhanced IE62 activation of ORF3 and gI promoters while Sp3 reduced IE62 activation of ORF28/29 promoter and VZV DNA replication. Sp2 reduced IE62 transactivation of gI while Sp1 had no significant influence on IE62 activation with any of these viral promoters. Electrophoretic mobility shift assays (EMSA) confirmed binding of Sp1 and Sp3 but not Sp2 and Sp4 to the gI promoter. Sp1-4 bound to IE62 and amino acids 238-258 of IE62 were important for the interaction with Sp3 and Sp4 as well as Sp1. This work shows that Sp family members have differential effects on IE62-mediated transactivation in a promoter-dependent manner.

  9. Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.

    Science.gov (United States)

    Burgdorf, Sarah W; Clark, Charles L; Burgdorf, James R; Spector, Deborah H

    2011-11-01

    The IE2 86 protein of human cytomegalovirus (HCMV) is essential for productive infection. The mutation of glutamine to arginine at position 548 of IE2 86 causes the virus to grow both slowly and to very low titers, making it difficult to study this mutant via infection. In this study, Q548R IE2 86 HCMV was produced on the complementing cell line 86F/40HA, which allowed faster and higher-titer production of mutant virus. The main defects observed in this mutant were greatly decreased expression of IE2 40, IE2 60, UL83, and UL84. Genome replication and the induction of cell cycle arrest were found to proceed at or near wild-type levels, and there was no defect in transitioning to early or late protein expression. Q548R IE2 86 was still able to interact with UL84. Furthermore, Q548R IE2 40 maintained the ability to enhance UL84 expression in a cotransfection assay. Microarray analysis of Q548R IE2 HCMV revealed that the US8, US9, and US29-32 transcripts were all significantly upregulated. These results further confirm the importance of IE2 in UL83 and UL84 expression as well as pointing to several previously unknown regions of the HCMV genome that may be regulated by IE2.

  10. Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus

    Science.gov (United States)

    Hou, Wangheng; Torres, Lilith; Cruz-Cosme, Ruth; Arroyo, Fernando; Irizarry, Luis; Luciano, Dalia; Márquez, Arturo; Rivera, Leslie L.; Sala, Antonio L.; Luo, Min-hua

    2016-01-01

    ABSTRACT The human cytomegalovirus (HCMV) major immediate early (MIE) gene is essential for viral replication. The most abundant products encoded by the MIE gene include IE1 and IE2. Genes of IE1 and IE2 share the MIE promoter (MIEP), the first 3 exons, and the first 2 introns. IE1 is expressed earlier than IE2 after CMV infection or MIE gene transfection. In this study, we identified 2 polypyrimidine (Py) tracts in intron 4 (between exons 4 and 5) that are responsible for transcriptional switching from IE1 to IE2. The first Py is important and the second one is essential for the splicing and expression of IE2. In searching for the mechanisms of MIE gene switching from IE1 to IE2, we found that the second Py was required for the IE2's fourth intron to bind to a splicing factor such as U2AF65, as determined by an RNA electrophoretic mobility shift assay and a chromatin immunoprecipitation (ChIP) assay, while the first Py enhanced the binding of U2AF65 with the intron. An HCMV BACmid with the second Py mutated failed to produce any virus, while the HCMV with the first Py mutated replicated with a defective phenotype. Furthermore, we designed a small RNA (scRNAPy) that is complementary to the intron RNA covering the two Pys. The scRNAPy interfered with the interaction of U2AF65 with the intron and repressed the IE2 expression. Therefore, our studies implied that IE2 gene splicing might be an anti-CMV target. IMPORTANCE CMV is a ubiquitous herpesvirus and a significant cause of disease and death in the immunocompromised and elderly. Insights into its gene regulation will provide clues in designing anti-CMV strategies. The MIE gene is one of the earliest genes of CMV and is essential for CMV replication. It is known that the MIE gene needs to be spliced to produce more than two proteins; however, how MIE gene splicing is regulated remains elusive. In the present studies, we identified two Pys in intron 4 and found that the first Py is important and the second is

  11. Developing a Global Model of Accounting Education and Examining IES Compliance in Australia, Japan, and Sri Lanka

    Science.gov (United States)

    Watty, Kim; Sugahara, Satoshi; Abayadeera, Nadana; Perera, Luckmika

    2013-01-01

    The introduction of International Education Standards (IES) signals a clear move by the International Accounting Education Standards Board (IAESB) to ensure high quality standards in professional accounting education at a global level. This study investigated how IES are perceived and valued by member bodies and academics in three counties:…

  12. Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication.

    Science.gov (United States)

    Khalil, Mohamed I; Che, Xibing; Sung, Phillip; Sommer, Marvin H; Hay, John; Arvin, Ann M

    2016-05-01

    VZV IE62 is an essential, immediate-early, tegument protein and consists of five domains. We generated recombinant viruses carrying mutations in the first three IE62 domains and tested their influence on VZV replication kinetics. The mutations in domain I did not affect replication kinetics while domain II mutations, disrupting the DNA binding and dimerization domain (DBD), were lethal for VZV replication. Mutations in domain III of the nuclear localization signal (NLS) and the two phosphorylation sites S686A/S722A resulted in slower growth in early and late infection respectively and were associated with IE62 accumulation in the cytoplasm and nucleus respectively. This study mapped the functional domains of IE62 in context of viral infection, indicating that DNA binding and dimerization domain is essential for VZV replication. In addition, the correct localization of IE62, whether nuclear or cytoplasmic, at different points in the viral life cycle, is important for normal progression of VZV replication.

  13. The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1 Protein Disrupts Type II Inteferon Signaling

    Directory of Open Access Journals (Sweden)

    Bindu Raghavan

    2014-04-01

    Full Text Available Interferons (IFNs activate the first lines of defense against viruses, and promote innate and adaptive immune responses to viruses. We report that the immediate early 1 (IE1 protein of human cytomegalovirus (HCMV disrupts signaling by IFNγ. The carboxyl-terminal region of IE1 is required for this function. We found no defect in the initial events in IFNγ signaling or in nuclear accumulation of signal transducer and activator of transcription 1 (STAT1 in IE1-expressing cells. Moreover, we did not observe an association between disruption of IFNγ signaling and nuclear domain 10 (ND10 disruption. However, there is reduced binding of STAT1 homodimers to target gamma activated sequence (GAS elements in the presence of IE1. Co-immunoprecipitation studies failed to support a direct interaction between IE1 and STAT1, although these studies revealed that the C-terminal region of IE1 was required for interaction with STAT2. Together, these results indicate that IE1 disrupts IFNγ signaling by interfering with signaling events in the nucleus through a novel mechanism.

  14. Consumption of Bt Maize Pollen Containing Cry1Ie Does Not Negatively Affect Propylea japonica (Thunberg (Coleoptera: Coccinellidae

    Directory of Open Access Journals (Sweden)

    Yonghui Li

    2017-03-01

    Full Text Available Propylea japonica (Thunberg (Coleoptera: Coccinellidae are prevalent predators and pollen feeders in East Asian maize fields. They are therefore indirectly (via prey and directly (via pollen exposed to Cry proteins within Bt-transgenic maize fields. The effects of Cry1Ie-producing transgenic maize pollen on the fitness of P. japonica was assessed using two dietary-exposure experiments in the laboratory. In the first experiment, survival, larval developmental time, adult fresh weight, and fecundity did not differ between ladybirds consuming Bt or non-Bt maize pollen. In the second experiment, none of the tested lethal and sublethal parameters of P. japonica were negatively affected when fed a rapeseed pollen-based diet containing Cry1Ie protein at 200 μg/g dry weight of diet. In contrast, the larval developmental time, adult fresh weight, and fecundity of P. japonica were significantly adversely affected when fed diet containing the positive control compound E-64. In both experiments, the bioactivity of the Cry1Ie protein in the food sources was confirmed by bioassays with a Cry1Ie-sensitive lepidopteran species. These results indicated that P. japonica are not affected by the consumption of Cry1Ie-expressing maize pollen and are not sensitive to the Cry1Ie protein, suggesting that the growing of Bt maize expressing Cry1Ie protein will pose a negligible risk to P. japonica.

  15. Consumption of Bt Maize Pollen Containing Cry1Ie Does Not Negatively Affect Propylea japonica (Thunberg) (Coleoptera: Coccinellidae).

    Science.gov (United States)

    Li, Yonghui; Liu, Yanmin; Yin, Xinming; Romeis, Jörg; Song, Xinyuan; Chen, Xiuping; Geng, Lili; Peng, Yufa; Li, Yunhe

    2017-03-16

    Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) are prevalent predators and pollen feeders in East Asian maize fields. They are therefore indirectly (via prey) and directly (via pollen) exposed to Cry proteins within Bt-transgenic maize fields. The effects of Cry1Ie-producing transgenic maize pollen on the fitness of P. japonica was assessed using two dietary-exposure experiments in the laboratory. In the first experiment, survival, larval developmental time, adult fresh weight, and fecundity did not differ between ladybirds consuming Bt or non-Bt maize pollen. In the second experiment, none of the tested lethal and sublethal parameters of P. japonica were negatively affected when fed a rapeseed pollen-based diet containing Cry1Ie protein at 200 μg/g dry weight of diet. In contrast, the larval developmental time, adult fresh weight, and fecundity of P. japonica were significantly adversely affected when fed diet containing the positive control compound E-64. In both experiments, the bioactivity of the Cry1Ie protein in the food sources was confirmed by bioassays with a Cry1Ie-sensitive lepidopteran species. These results indicated that P. japonica are not affected by the consumption of Cry1Ie-expressing maize pollen and are not sensitive to the Cry1Ie protein, suggesting that the growing of Bt maize expressing Cry1Ie protein will pose a negligible risk to P. japonica.

  16. Consumption of Bt Maize Pollen Containing Cry1Ie Does Not Negatively Affect Propylea japonica (Thunberg) (Coleoptera: Coccinellidae)

    Science.gov (United States)

    Li, Yonghui; Liu, Yanmin; Yin, Xinming; Romeis, Jörg; Song, Xinyuan; Chen, Xiuping; Geng, Lili; Peng, Yufa; Li, Yunhe

    2017-01-01

    Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) are prevalent predators and pollen feeders in East Asian maize fields. They are therefore indirectly (via prey) and directly (via pollen) exposed to Cry proteins within Bt-transgenic maize fields. The effects of Cry1Ie-producing transgenic maize pollen on the fitness of P. japonica was assessed using two dietary-exposure experiments in the laboratory. In the first experiment, survival, larval developmental time, adult fresh weight, and fecundity did not differ between ladybirds consuming Bt or non-Bt maize pollen. In the second experiment, none of the tested lethal and sublethal parameters of P. japonica were negatively affected when fed a rapeseed pollen-based diet containing Cry1Ie protein at 200 μg/g dry weight of diet. In contrast, the larval developmental time, adult fresh weight, and fecundity of P. japonica were significantly adversely affected when fed diet containing the positive control compound E-64. In both experiments, the bioactivity of the Cry1Ie protein in the food sources was confirmed by bioassays with a Cry1Ie-sensitive lepidopteran species. These results indicated that P. japonica are not affected by the consumption of Cry1Ie-expressing maize pollen and are not sensitive to the Cry1Ie protein, suggesting that the growing of Bt maize expressing Cry1Ie protein will pose a negligible risk to P. japonica. PMID:28300767

  17. 毛萼香茶菜二萜合酶IeCPS的立体特异性研究%Analysis on Stereospeciifty of Diterpene Synthases IeCPS fromIsodon eriocalyx

    Institute of Scientific and Technical Information of China (English)

    杜刚; 龚海艳; 高娟; 付小莉; 卢山; 曾英

    2015-01-01

    Ent-kaurane diterpenoids, isolated from the Chinese medicinal herbs,Isodon L., are principle com-ponents showing potent bioactivities of antitumor and anti-autoimmune inlfammation. Despite a large number ofent-kaurane diterpenoids isolated fromIsodon plants, little is known about the enzymatic machinery involved in their biosynthesis. IeCPS1 and IeCPS2 encoding copalyl diphosphate synthases (CPS) were previ-ously cloned from the I. eriocalyx leaves and functionally characterized. Here we verified that IeCPS1 and IeCPS2 wereent-CPSs that produced CPP ofent-stereochemistry, by GC-MS analysis of enzymatic products from coupled reactions with a knownArabidopsis ent-kaurene synthase stereospeciifc forent-CPP.%对映-贝壳杉烷型二萜是药用植物香茶菜抗菌抗肿瘤的核心组分,其生物合成的酶分子机制尚未完全明了。前期我们克隆并鉴定了毛萼香茶菜二萜合酶柯巴基焦磷酸合酶基因IeCPS1和IeCPS2。本文通过与拟南芥对映-贝壳杉烯二萜合酶AtKS配对进行偶联反应,以及GC-MS鉴定酶联反应产物,证实毛萼香茶菜二萜合酶IeCPS1和IeCPS2的立体特异性为对映型(ent-CPS)。

  18. Amino acid 1-209 is essential for PDX-1-mediated repression of human CMV IE promoter activity

    Institute of Scientific and Technical Information of China (English)

    Jing CHEN; Lei CHEN; Ge LI; Lu CHENG; Yin HUANG; Jia-xin ZHANG; Wei-wei FAN; Da-ru LU

    2006-01-01

    Aim: To explore the different roles of pancreatic duodenal homeobox factors-1 (PDX-1) domains in PDX-1 mediated repression of human cytomegalovirus immediately early (CMV IE) promoter. Methods: A series of truncated PDX-1 mutants were constructed. The binding of PDX-1 and CMV IE promoter was identified by electrophoretic mobility shift assay (EMSA). The dual-reporter assay was applied to examine the repression activities of PDX-1 mutants on CMV IE promoter. In addition, RNAi technology was used to specifically knock down the endogenous PDX-1 expression. Results: The reporter assay indicated that compared to the mock controls (pEGFP-N2), overexpression of PDX-1 resulted in a 41% decrease of CMV IE promoter activity in the 293 cells (P<0.05) and 43% decrease in HeLa cells (P<0.05), and the repression levels of various truncated mutants played on CMV IE promoter were different. Specific knock down of the endogenous PDX-1 expression significantly restored the activity of CMV IE promoter. EMS A demonstrated that domain 3 is necessary for nuclear localization and DNA binding activity of PDX-1. However, binding of PDX-1 alone to CMV IE promoter was not sufficient to inhibit its transcriptional activity, and other domains of PDX-1 presented were also required. Conclusion: Our data suggested that the DNA binding activity of PDX-1 domain 3 and the cooperative binding of PDX-1 domain 1/2 with other proteins were required for PDX-1 mediated repression of CMV IE promoter.

  19. Om Ie en wag.

    African Journals Online (AJOL)

    But whereas conjoined sentences such as (lIb) can also be read to indicate .... When viewed dispassionately, however, Kempen's etymology leaves several issues .... view, one would have to show that the paragogic vowel in staane is to be ...

  20. Sf-PHB2, A new transcription factor, Drives WSSV Ie1 Gene Expression via a 12-bp DNA Element

    Directory of Open Access Journals (Sweden)

    Ma Guoda

    2012-09-01

    Full Text Available Abstract Background The WSSV immediate early gene ie1 is highly expressed throughout viral infection cycle and may play a central role in initiating viral replication during infection. Results Here, a detailed characterization of the ie1 promoter was performed using deletion and mutation analyses to elucidate the role of the individual promoter motifs. Three results were obtained: 1 the ie1 promoter is a classical eukaryotic promoter that contains the initiator element (Inr and TATA box responsible for the basal promoter activity; 2 mutation or truncation of a predicted Sp1 site decreased the level of promoter activity by about 3-fold, indicating that the Sp1 site is an important cis-element of the promoter; and 3 truncation of a 12-bp sequence that resides at -78/-67 of the ie1 promoter decreased the level of promoter activity by about 14-fold, indicating that the 12-bp motif is a critical upstream element of the ie1 promoter for binding of a strong transcription factor to drive the ie1 gene expression in the cells. Further, the 12-bp DNA binding protein was purified from the nuclear proteins of Sf9 cells using DNA affinity chromatography, and was identified as a homologue of the prohibitin2 protein (named as Sf-PHB2 using mass spectrometry. Furthermore, the DNA binding activity of Sf-PHB2 was verified using a super shift analysis. Conclusion These results support that the Sf-PHB2 is a novel transcription factor that drives WSSV ie1 gene expression by binding to the 12-bp DNA element.

  1. The Øie-Tozer model of drug distribution and its suitability for drugs with different pharmacokinetic behavior.

    Science.gov (United States)

    Stepensky, David

    2011-10-01

    Drug distribution is a major pharmacokinetic process that affects the time course of drug concentrations in tissues, biological fluids and the resulting pharmacological activities. Drug distribution may follow different pathways and patterns, and is governed by the drug's physicochemical properties and the body's physiology. The classical Øie-Tozer model is frequently used for predicting volume of drug distribution and for pharmacokinetic calculations. In this review, the suitability of the Øie-Tozer model for drugs that exhibit different distribution patterns is critically analyzed and illustrated. The method used is a pharmacokinetic modeling and simulation approach. It is demonstrated that the major limitation of the Øie-Tozer model stems from its focus on the total drug concentrations and not on the active (unbound) concentrations. Moreover, the Øie-Tozer model may be inappropriate for drugs with nonlinear or complex pharmacokinetic behavior, such as biopharmaceuticals, drug conjugates or for drugs incorporated into drug delivery systems. Distribution mechanisms and alternative distribution models for these drugs are discussed. The Øie-Tozer model can serve for predicting unbound volume of drug distribution for 'classical' small molecular mass drugs with linear pharmacokinetics. However, more detailed mechanism-based distribution models should be used in preclinical and clinical settings for drugs that exhibit more complex pharmacokinetic behavior.

  2. Penetration of a Single Domain of Bacillus thuringiensis Cry1Ie-Domain I to a Lipid Membrane In vitro

    Institute of Scientific and Technical Information of China (English)

    GUO Shu-yuan; LI Jie; CHEN Zhen; HE Kang-lai

    2014-01-01

    Domain I of the activated Crystal protein from Bacillus thuringiensis has a sevenα-helix bundle structure, which is responsible for membrane channel formation in its insecticidal mechanism. Cry1Ie is toxic to Asian corn borer, Ostrinia furnacalis (Guenée), and plays important roles in insect biological control. The domain I from Cry1Ie has been expressed and puriifed in its normal conformation, as embedded in the full length homologous toxin structure. The membrane insertion ability of this single domain was compared with the full length homologous toxin using a monolayer insertion experiment. The results indicated that the Cry1Ie-domain I had the ability to insert into the lipid monolayer, and this ability is greater than that of the IE648 toxin. However, the state of insertion is not stable and remains for only a short period of time. The Cry1Ie-domain I plays no role in receptor binding as it had a nonspeciifc binding with the brush border membrane vesicles of the Asian corn borer.

  3. A 4 Farad high energy electrochemical double layer capacitor prototype operating at 3.2 V (IES prototype)

    Science.gov (United States)

    Varzi, A.; Schütter, C.; Krummacher, J.; Raccichini, R.; Wolff, C.; Kim, G.-T.; Rösler, S.; Blumenröder, B.; Schubert, T.; Passerini, S.; Balducci, A.

    2016-09-01

    In this manuscript we report about the realization and testing of a high-voltage electrochemical double layer capacitor (EDLC) prototype (IES prototype), which has been assembled using innovative electrode and electrolyte components. The IES prototype displays a nominal capacitance of 4 F, a maximum voltage of 3.2 V and its maximal energy and power are in the order of 37 Wh kg-1 and 65 kW kg-1, respectively. Furthermore, it also displays good cycling stability, high capacitance retention after 80 h float test and acceptable self-discharge. Taking into account substantial improvements of the cell design and assembly procedure, the performance of the IES prototype indicates that the components utilized in this device might be suitable alternatives to the state-of-the-art materials used in high energy EDLCs.

  4. Fribrinolytic activity and gas production by Pleurotus ostreatus-IE8 and Fomes fomentarius - EUM1 in bagasse cane

    Directory of Open Access Journals (Sweden)

    Paulino Sánchez-Santillán

    2015-11-01

    Full Text Available Objective. To characterize the fibrolytic enzymatic activity of Pleurotus ostreatus-IE8 and Fomes fomentarius-EUM1 in sugarcane bagasse (BCA; to evaluation of the kinetics of in vitro production of BCA treated by solid fermentation (FS, crude enzyme extract (ECE of P. ostreatus-IE8 and Fibrozyme®. Materials and methods. In fungi measured radial growth rate ( Vcr and biomass production in two culture media (with or without nitrogen source; activity of xylanases, cellulases and FS on BCA at 0, 7 and 15 d. The chemical analysis and kinetic analysis of in vitro gas production in 4 treatments (ECE adding enzymes obtained from the direct addition FS or FS , witness (Fibrozyme® and a control without addition and analyzed by a was completely randomized design. Results. Xylanases (7 d showed 6.32 and 5.50 UI g-1 initial substrate dry weight (SSi for fungi P. ostreatus-IE8 and F. fomentarius-EUM1 , respectively ; P. ostreatus-IE8 scored higher activity of laccases (10.65 g -1 UI SSi and F. fomentarius-EUM1 (1.90 UI g-1 SSi cellulases. The ECE of P. ostreatus-IE8 and commercial enzyme did not differences (p>0.05. In the chemical composition or the gas production kinetics. The 4 treatments evaluated decreased values of the variables measured in the kinetics of gas production compared to the control (p≤0.05. Conclusions. The ECE of P. ostreatus-IE8 was similar to commercial enzyme degradation in vitro, so it is feasible to use pre-digest high fiber products.

  5. Advanced dexterous manipulation for IED defeat : report on the feasibility of using the ShadowHand for remote operations.

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Robert J.

    2011-01-01

    Improvised Explosive Device (IED) defeat (IEDD) operations can involve intricate operations that exceed the current capabilities of the grippers on board current bombsquad robots. The Shadow Dexterous Hand from the Shadow Robot Company or 'ShadowHand' for short (www.shadowrobot.com) is the first commercially available robot hand that realistically replicates the motion, degrees-of-freedom and dimensions of a human hand (Figure 1). In this study we evaluate the potential for the ShadowHand to perform potential IED defeat tasks on a mobile platform.

  6. Elementary Teachers' Learning to Construct High-Quality Mathematics Lesson Plans: A Use of the IES Recommendations

    Science.gov (United States)

    Ding, Meixia; Carlson, Mary Alice

    2013-01-01

    This study explored a group of elementary teachers' ("n" = 35) learning to construct high-quality lesson plans that foster student understanding of fundamental mathematical ideas. The conceptual framework for this study was gleaned from the recently released Institute of Education Sciences (IES) recommendations, including (a)…

  7. Field trials to evaluate the effects of transgenic cry1Ie maize on the community characteristics of arthropod natural enemies.

    Science.gov (United States)

    Guo, Jingfei; He, Kanglai; Hellmich, Richard L; Bai, Shuxiong; Zhang, Tiantao; Liu, Yunjun; Ahmed, Tofael; Wang, Zhenying

    2016-02-26

    Possible non-target effect of transgenic cry1Ie maize exerts on natural enemy community biodiversity in the field is unresolved. In the present study, a 2-yr comparison of transgenic cry1Ie maize (Event IE09S034, Bt maize) and its near isoline (Zong 31, non-Bt maize) on natural enemy community biodiversity were compared with whole plant inspections, pitfall traps and suction sampler. Natural enemy diversity indices (Shannon-Wiener', Simpson's and Pielou's index) and abundance suggested there were no significant differences between the two types of maize. The only exceptions were the Pielou's index for whole plant inspections in 2013 and abundance for pitfall traps in 2012, which were significantly higher in Bt maize than those of non-Bt maize. The main species of natural enemies were identical in Bt and non-Bt maize plots for each method and the three methods combined. For whole plant inspections, Bt maize had no time-dependent effect on the entire arthropod natural enemy community, and also no effect on community dissimilarities between Bt and non-Bt maize plots. These results suggested that despite the presence of a relatively minor difference in natural enemy communities between Bt and non-Bt maize, transgenic cry1Ie maize had little, if any, effect on natural enemy community biodiversity.

  8. Effects of transgenic cry1Ie maize on non-lepidopteran pest abundance, diversity and community composition.

    Science.gov (United States)

    Guo, Jingfei; He, Kanglai; Bai, Shuxiong; Zhang, Tiantao; Liu, Yunjun; Wang, Fuxin; Wang, Zhenying

    2016-12-01

    Non-lepidopteran pests are exposed to, and may be influenced by, Bt toxins when feeding on Bt maize that express insecticidal Cry proteins derived from Bacillus thuringiensis (Bt). In order to assess the potential effects of transgenic cry1Ie maize on non-lepidopteran pest species and ecological communities, a 2-year field study was conducted to compare the non-lepidopteran pest abundance, diversity and community composition between transgenic cry1Ie maize (Event IE09S034, Bt maize) and its near isoline (Zong 31, non-Bt maize) by whole plant inspections. Results showed that Bt maize had no effects on non-lepidopteran pest abundance and diversity (Shannon-Wiener diversity index, Simpson's diversity index, species richness, and Pielou's index). There was a significant effect of year and sampling time on those indices analyzed. Redundancy analysis indicated maize type, sampling time and year totally explained 20.43 % of the variance in the non-lepidopteran pest community composition, but no association was presented between maize type (Bt maize and non-Bt maize) and the variance. Nonmetric multidimensional scaling analysis showed that sampling time and year, rather than maize type had close relationship with the non-lepidopteran pest community composition. These results corroborated the hypothesis that, at least in the short-term, the transgenic cry1Ie maize had negligible effects on the non-lepidopteran pest abundance, diversity and community composition.

  9. The Impact of Inclusive Education (IE) on the Rights of Children with Intellectual Disabilities (IDs) in Chegutu

    Science.gov (United States)

    Mapuranga, Barbra; Dumba, Oswald; Musodza, Blessing

    2015-01-01

    This study investigated the impact of Inclusive Education (IE) on the rights of children with Intellectual Disabilities in schools around Chegutu. The qualitative case study method was used for the research. Questionnaires and interviews were used to collect data from schools around Chegutu. Random sampling was used to choose the sample group from…

  10. IED Cleanup: A Cooperative Classroom Robotics Challenge--The Benefits and Execution of a Cooperative Classroom Robotics Challenge

    Science.gov (United States)

    Piotrowski, Mark; Kressly, Rich

    2009-01-01

    This article describes a cooperative classroom robotics challenge named "IED Cleanup". This classroom challenge was created to incorporate a humanitarian project with the use of a robotics design system in order to remove simulated IEDs (Improvised Explosive Devices) to a detonation zone within a specified amount of time. Throughout the activity,…

  11. The need for combining IEA and IE tools. The potential effects of a global ban on PVC on climate change

    Energy Technology Data Exchange (ETDEWEB)

    Kleijn, Rene; Van der Voet, Ester; Udo de Haes, Helias A. [Institute of Environmental Sciences, Leiden University, P.O. Box 9518, 2300 RA Leiden (Netherlands)

    2008-04-01

    Over the last decades the concepts of Integrated Environmental Assessment (IEA) and Industrial Ecology (IE), both claiming to provide analyses and solutions for sustainability issues, have been developed separately as they emerged in response to questions from different policy-fields. In both fields, specific tools are used to support national and international environmental policy. The focus of IEA and IE tools, however, is different. IEA tools focus on one or a limited number of specific environmental issues. They often model the chain environmental processes with high spatial (and temporal) resolution, but have a low resolution for the material structure of the economy and only partly take into account indirect effects that occur via physical and socio-economic linkages. IE tools take into account all environmental issues related to a specific substance or product. They have a high resolution for the material structure of the economy and take into account indirect effects that occur via physical linkages, however, their environmental modelling is very limited. Both IE and IEA tools have proven to be very useful and neither is superior to the other. However, a combination of both can provide additional information that can be used for more effective policy making. We use the case of a hypothetical world-wide ban on PVC to show that a measure that is not directly related to climate change could still have significant climate effects. This indirect effect is a result of the linkages of material flows in society. We show that IEA tools are not well suited to include these types of effects and that IE tools can fill this gap partially. What is really needed is a broader systems perspective that takes into account the full range of possible side-effects of environmental policy measures. (author)

  12. Design of USB Interface on MuItipIe PhysioIogicaI Parameter Acquisition ModuIe%多通道生理参数采集模块的USB接口设计

    Institute of Scientific and Technical Information of China (English)

    高勇; 闫聪聪

    2016-01-01

    采用USB接口芯片和多通道生理参数采集模块设计了一种采集模块与上位机PC通信的USB接口,实现了多通道生理参数的实时数据采集。从通信实现的上位机和下位机两方面讨论了接口的设计和实现过程。阐述了基于PC的上位机驱动程序设计,基于USB接口芯片的下位机硬件设计和固件设计,与PC串口通信对比了数据通信的实时性和准确性。%This paper introduces the design of USB interface used on muItipIe physioIogicaI parameter acquistion moduIe. The hardware is achieved by MCU and USB controI IC.The firmware of USB simuIated doubIe-thread function.The CircuIar data buffer is used in data processing.It gave the core code about the WDM driver and appIiction program.Last,the reaI-time and accuracy is compared.

  13. COMPETENŢA DE INVESTIGAŢIE, IMPERATIV AL SOCIETĂŢII AXATE PE CUNOAŞTERE

    OpenAIRE

    2015-01-01

    Contextul amplelor schimbări tehnologice determină specificul societăţii axate pe cunoaştere. Politicile cunoaşterii, în acest context, se referă la cercetare, inovaţie, educaţie şi la formarea profesională; politicile educaţionale se referă la trecerea progresivă de la behaviorism spre pragmatism, şi anume: de la acţiune în baza analogiilor, fără implicarea con-ştiinţei (teoria behavioristă) la acţiune de cercetare care presupune rezolvarea problemelor din viaţă. Educaţia elevilor, în acest ...

  14. Resources for global risk assessment: the International Toxicity Estimates for Risk (ITER) and Risk Information Exchange (RiskIE) databases.

    Science.gov (United States)

    Wullenweber, Andrea; Kroner, Oliver; Kohrman, Melissa; Maier, Andrew; Dourson, Michael; Rak, Andrew; Wexler, Philip; Tomljanovic, Chuck

    2008-11-15

    The rate of chemical synthesis and use has outpaced the development of risk values and the resolution of risk assessment methodology questions. In addition, available risk values derived by different organizations may vary due to scientific judgments, mission of the organization, or use of more recently published data. Further, each organization derives values for a unique chemical list so it can be challenging to locate data on a given chemical. Two Internet resources are available to address these issues. First, the International Toxicity Estimates for Risk (ITER) database (www.tera.org/iter) provides chronic human health risk assessment data from a variety of organizations worldwide in a side-by-side format, explains differences in risk values derived by different organizations, and links directly to each organization's website for more detailed information. It is also the only database that includes risk information from independent parties whose risk values have undergone independent peer review. Second, the Risk Information Exchange (RiskIE) is a database of in progress chemical risk assessment work, and includes non-chemical information related to human health risk assessment, such as training modules, white papers and risk documents. RiskIE is available at http://www.allianceforrisk.org/RiskIE.htm, and will join ITER on National Library of Medicine's TOXNET (http://toxnet.nlm.nih.gov/). Together, ITER and RiskIE provide risk assessors essential tools for easily identifying and comparing available risk data, for sharing in progress assessments, and for enhancing interaction among risk assessment groups to decrease duplication of effort and to harmonize risk assessment procedures across organizations.

  15. The Populus Genome Integrative Explorer (PopGenIE): a new resource for exploring the Populus genome.

    Science.gov (United States)

    Sjödin, Andreas; Street, Nathaniel Robert; Sandberg, Göran; Gustafsson, Petter; Jansson, Stefan

    2009-06-01

    Populus has become an important model plant system. However, utilization of the increasingly extensive collection of genetics and genomics data created by the community is currently hindered by the lack of a central resource, such as a model organism database (MOD). Such MODs offer a single entry point to the collection of resources available within a model system, typically including tools for exploring and querying those resources. As a starting point to overcoming the lack of such an MOD for Populus, we present the Populus Genome Integrative Explorer (PopGenIE), an integrated set of tools for exploring the Populus genome and transcriptome. The resource includes genome, synteny and quantitative trait locus (QTL) browsers for exploring genetic data. Expression tools include an electronic fluorescent pictograph (eFP) browser, expression profile plots, co-regulation within collated transcriptomics data sets, and identification of over-represented functional categories and genomic hotspot locations. A number of collated transcriptomics data sets are made available in the eFP browser to facilitate functional exploration of gene function. Additional homology and data extraction tools are provided. PopGenIE significantly increases accessibility to Populus genomics resources and allows exploration of transcriptomics data without the need to learn or understand complex statistical analysis methods. PopGenIE is available at www.popgenie.org or via www.populusgenome.info.

  16. Remarks on Vertex-Distinguishing IE-Total Coloring of Complete Bipartite Graphs K4,n and Kn,n

    Institute of Scientific and Technical Information of China (English)

    Xiang'en CHEN; Xiaoqing XIN; Wenyu HE

    2012-01-01

    Let G be a simple graph.An IE-total coloring f of G refers to a coloring of the vertices and edges of G so that no two adjacent vertices receive the same color.Let C(u) be the set of colors of vertex u and edges incident to u under f.For an IE-total coloring f of G using k colors,if C(u) ≠ C(v) for any two different vertices u and v of V(G),then f is called a k-vertex-distinguishing IE-total-coloring of G,or a k-VDIET coloring of G for short.The minimum number of colors required for a VDIET coloring of G is denoted by xievt(G),and it is called the VDIET chromatic number of G.We will give VDIET chromatic numbers for complete bipartite graph K4,n (n ≥ 4),Kn,n (5 ≤ n ≤ 21) in this article.

  17. Versão brasileira da Impact of Event Scale (IES: tradução e adaptação transcultural Brazilian version of the Impact of Event Scale (IES: translation and cross-cultural adaptation

    Directory of Open Access Journals (Sweden)

    Adriana Cardoso de Oliveira e Silva

    2010-01-01

    Full Text Available INTRODUÇÃO: A Impact of Event Scale (IES tem como proposta avaliar o estresse subjetivo relacionado a eventos de vida, não estando focada em uma situação específica, mas nas características particulares que envolvem tais eventos. OBJETIVO: Descrever a tradução e adaptação semântica da IES para o português brasileiro. MÉTODO: O processo foi realizado por meio de duas traduções e retrotraduções, elaboradas por quatro avaliadores independentes e sem conhecimento prévio da escala original. A elaboração da versão sintética foi realizada por especialista em saúde mental bilíngue. Procedeu-se a posterior aplicação em grupo experimental para avaliação dos itens. A versão gerada foi enviada para aprovação do autor do instrumento original, obtendo-se resposta positiva. RESULTADOS: Todas as etapas do processo, incluindo traduções, retrotraduções e a versão sintética elaborada, são apresentadas para cada um dos 15 itens do instrumento original. O especialista em saúde mental colaborou para a adequação dos termos utilizados em relação ao construto medido. Através da aplicação experimental, foi possível identificar potenciais pontos de dificuldade para o entendimento de itens específicos e realizar ajustes posteriores. Foram obtidos 15 itens em português brasileiro para compor essa versão da escala. CONCLUSÕES: A partir da metodologia utilizada, foi possível elaborar a adaptação transcultural da IES para o português brasileiro.INTRODUCTION: The aim of the Impact of Event Scale (IES is to evaluate subjective distress associated with life events. The instrument is not focused on a specific situation, but rather on the particular characteristics of such events. OBJECTIVE: To describe the translation and semantic adaptation of the IES into Brazilian Portuguese. METHODS: The process consisted of translations and back-translations performed by four independent examiners without prior knowledge of the original

  18. Regimental Combat Team One in Afghanistan: A Case Study into the Organization and Operation of a Tactical Level C-IED Cell

    Science.gov (United States)

    2012-04-26

    Clearance Vehicles WTI IED Lexicon CEXC EOD Operations IED Components JEFF Robots IED Reporting Requirments JPEC Road Repair Operations Biometrics...Penetrating Radar WTI /WIT C-IED Battle Rhythm Threat Financing Dismounted Movement Emerging Technologies Unmanned Ground Sensors STO Programs ACCM...progress. Weapons Technical Intelligence ( WTI ): As the Marine Corps C-IED doctrine states, “ WTI provides critical forensics to identify adversary

  19. Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

    Science.gov (United States)

    Smith, Clyde A; Toth, Marta; Bhattacharya, Monolekha; Frase, Hilary; Vakulenko, Sergei B

    2014-06-01

    The bifunctional acetyltransferase(6')-Ie-phosphotransferase(2'')-Ia [AAC(6')-Ie-APH(2'')-Ia] is the most important aminoglycoside-resistance enzyme in Gram-positive bacteria, conferring resistance to almost all known aminoglycoside antibiotics in clinical use. Owing to its importance, this enzyme has been the focus of intensive research since its isolation in the mid-1980s but, despite much effort, structural details of AAC(6')-Ie-APH(2'')-Ia have remained elusive. The structure of the Mg2GDP complex of the APH(2'')-Ia domain of the bifunctional enzyme has now been determined at 2.3 Å resolution. The structure of APH(2'')-Ia is reminiscent of the structures of other aminoglycoside phosphotransferases, having a two-domain architecture with the nucleotide-binding site located at the junction of the two domains. Unlike the previously characterized APH(2'')-IIa and APH(2'')-IVa enzymes, which are capable of utilizing both ATP and GTP as the phosphate donors, APH(2'')-Ia uses GTP exclusively in the phosphorylation of the aminoglycoside antibiotics, and in this regard closely resembles the GTP-dependent APH(2'')-IIIa enzyme. In APH(2'')-Ia this GTP selectivity is governed by the presence of a `gatekeeper' residue, Tyr100, the side chain of which projects into the active site and effectively blocks access to the adenine-binding template. Mutation of this tyrosine residue to a less bulky phenylalanine provides better access for ATP to the NTP-binding template and converts APH(2'')-Ia into a dual-specificity enzyme.

  20. 防止Office和IE通过网络泄密%Preventing Office and IE from Network Divulgence

    Institute of Scientific and Technical Information of China (English)

    朱建红

    2002-01-01

    @@ 一、我需要守住秘密吗? 谁都知道,目前不少公司或者个人通过网络暗地里搜集商业秘密或个人隐私.你也许认为自己从来没有遇到过,其实如果你正在使用IE 5.0或更高版本,或者Office XP,那么很可能已经在不知不觉中将自己的秘密泄露了出去.

  1. High-level gene expression in Aedes albopictus cells using a baculovirus Hr3 enhancer and IE1 transactivator

    Directory of Open Access Journals (Sweden)

    Gray Christine E

    2004-07-01

    Full Text Available Abstract Background Aedes aegypti is the key vector of both the Yellow Fever and Dengue Fever viruses throughout many parts of the world. Low and variable transgene expression levels due to position effect and position effect variegation are problematic to efforts to create transgenic laboratory strains refractory to these viruses. Transformation efficiencies are also less than optimal, likely due to failure to detect expression from all integrated transgenes and potentially due to limited expression of the transposase required for transgene integration. Results Expression plasmids utilizing three heterologous promoters and three heterologous enhancers, in all possible combinations, were tested. The Hr3/IE1 enhancer-transactivator in combination with each of the constitutive heterologous promoters tested increased reporter gene expression significantly in transiently transfected Aedes albopictus C7-10 cells. Conclusions The addition of the Hr3 enhancer to expression cassettes and concomitant expression of the IE1 transactivator gene product is a potential method for increasing the level of transgene expression in insect systems. This mechanism could also potentially be used to increase the level of transiently-expressed transposase in order to increase the number of integration events in transposon-mediated transformation experiments.

  2. Presenting Your Best Self(ie: The Influence of Gender on Vertical Orientation of Selfies on Tinder

    Directory of Open Access Journals (Sweden)

    Lorin J. Elias

    2017-04-01

    Full Text Available When taking a self-portrait or “selfie” to display in an online dating profile, individuals may intuitively manipulate the vertical camera angle to embody how they want to be perceived by the opposite sex. Concepts from evolutionary psychology and grounded cognition suggest that this manipulation can provide cues of physical height and impressions of power to the viewer which are qualities found to influence mate-selection. We predicted that men would orient selfies more often from below to appear taller (i.e., more powerful than the viewer, and women, from an above perspective to appear shorter (i.e., less powerful. A content analysis was conducted which coded the vertical orientation of 557 selfies from profile pictures on the popular mobile dating application, Tinder. In general, selfies were commonly used by both men (54% and women (90%. Consistent with our predictions, a gender difference emerged; men's selfies were angled significantly more often from below, whereas women's were angled more often from above. Our findings suggest that selfies presented in a mate-attraction context are intuitively or perhaps consciously selected to adhere to ideal mate qualities. Further discussion proposes that biological or individual differences may also facilitate vertical compositions of selfies.

  3. Presenting Your Best Self(ie): The Influence of Gender on Vertical Orientation of Selfies on Tinder.

    Science.gov (United States)

    Sedgewick, Jennifer R; Flath, Meghan E; Elias, Lorin J

    2017-01-01

    When taking a self-portrait or "selfie" to display in an online dating profile, individuals may intuitively manipulate the vertical camera angle to embody how they want to be perceived by the opposite sex. Concepts from evolutionary psychology and grounded cognition suggest that this manipulation can provide cues of physical height and impressions of power to the viewer which are qualities found to influence mate-selection. We predicted that men would orient selfies more often from below to appear taller (i.e., more powerful) than the viewer, and women, from an above perspective to appear shorter (i.e., less powerful). A content analysis was conducted which coded the vertical orientation of 557 selfies from profile pictures on the popular mobile dating application, Tinder. In general, selfies were commonly used by both men (54%) and women (90%). Consistent with our predictions, a gender difference emerged; men's selfies were angled significantly more often from below, whereas women's were angled more often from above. Our findings suggest that selfies presented in a mate-attraction context are intuitively or perhaps consciously selected to adhere to ideal mate qualities. Further discussion proposes that biological or individual differences may also facilitate vertical compositions of selfies.

  4. Easy regulation of metabolic flux in Escherichia coli using an endogenous type I-E CRISPR-Cas system.

    Science.gov (United States)

    Chang, Yizhao; Su, Tianyuan; Qi, Qingsheng; Liang, Quanfeng

    2016-11-15

    Clustered regularly interspaced short palindromic repeats interference (CRISPRi) is a recently developed powerful tool for gene regulation. In Escherichia coli, the type I CRISPR system expressed endogenously shall be easy for internal regulation without causing metabolic burden in compared with the widely used type II system, which expressed dCas9 as an additional plasmid. By knocking out cas3 and activating the expression of CRISPR-associated complex for antiviral defense (Cascade), we constructed a native CRISPRi system in E. coli. Downregulation of the target gene from 6 to 82% was demonstrated using green fluorescent protein. Regulation of the citrate synthase gene (gltA) in the TCA cycle affected host metabolism. The effect of metabolic flux regulation was demonstrated by the poly-3-hydroxbutyrate (PHB) accumulation in vivo. By regulating native gltA in E. coli using an engineered endogenous type I-E CRISPR system, we redirected metabolic flux from the central metabolic pathway to the PHB synthesis pathway. This study demonstrated that the endogenous type I-E CRISPR-Cas system is an easy and effective method for regulating internal metabolic pathways, which is useful for product synthesis.

  5. COMPETENŢA DE INVESTIGAŢIE, IMPERATIV AL SOCIETĂŢII AXATE PE CUNOAŞTERE

    Directory of Open Access Journals (Sweden)

    Nina BÎRNAZ

    2015-11-01

    Full Text Available Contextul amplelor schimbări tehnologice determină specificul societăţii axate pe cunoaştere. Politicile cunoaşterii, în acest context, se referă la cercetare, inovaţie, educaţie şi la formarea profesională; politicile educaţionale se referă la trecerea progresivă de la behaviorism spre pragmatism, şi anume: de la acţiune în baza analogiilor, fără implicarea con-ştiinţei (teoria behavioristă la acţiune de cercetare care presupune rezolvarea problemelor din viaţă. Educaţia elevilor, în acest context, presupune nu doar achiziţii teoretice, dar şi formarea unui spirit de investigaţie, necesar pentru partici-parea activă la locul său în comunitate. Din această perspectivă, curriculumul şcolar promovează abordarea unui demers educaţional axat pe competenţe, prin prisma corelaţiei: iniţiativa profesorului – acţiunea elevului („learning by doing”. INVESTIGATION SKILL, KEY ELEMENT OF A SOCIETY CENTERED ON LEARNINGThe context of ample technological advances determines the specifics of a society centered on learning. The learning politics, in this context are referred to research, innovation, education and professional training; the educational politics refer to the progressive transition from behaviorism towards pragmatism, especially from actions based on analogies, without the implication of conscience (the behavioral theory in research, which implies the solving of life’s problems. The education of students, in this context, implies not just theoretical acquirement, but also the forming of a spirit of investigating, needed for an active participation in its place or inside the community. From this perspective, the school curriculum promotes the approach of an educational step based on skills, linking the teacher’s initiative with the student’s action (learning by doing.

  6. The effect of transgenic maize with cry1Ie gene on rhizosphere bacteria community structure%转 cry1Ie 基因抗虫玉米对土壤中细菌群落结构的影响

    Institute of Scientific and Technical Information of China (English)

    叶慧香; 崔跃原; 宋新元; 马娟; 万虎; 李建洪

    2015-01-01

    safety of genetically modified crops on soil bacteria was examined.[Method] The community structure of the rhizosphere in fields of transgenic cry1Ie maize and its parental non-Bt maize ( the control) were measured at different growth stages.This was assessed u-sing culture-independent technique polymerase chain reaction-denaturing gradient gel electrophoresis ( PCR-DGGE) and Phospholip-ids fatty acid (PLFA) assays.[Result] PLFA analysis showed that the bacteria biomass and G+/G-of transgenic cry1Ie maize and maize receptors control of 2012 had no significant difference at the same growth stage, but significant differences were detected for microbial biomass at different following stages.The values of G+/G-were greater than one, suggesting that at each growth stage, microbial biomass of Gram-positive bacteria was greater than Gram-negative bacteria.During the entire growing period, insect-resist-ant corn with cry1Ie receptor gene control was not a significant different than control corn.Tt was no significant difference in 2013 in the total amount of microbial and bacterial biomass and the ratio of Gram-positive bacteria and gram-negative bacteria between both corn types.The cluster analysis results showed no remarkable difference in DGGE profile of bacteria at the same growth stage.Corn rhizosphere bacterial community structure was relatively stable and similar in both 2012 and 2013.[Conclusion and significance]Two years of data showed that insect-resistant cry1Ie transgenic maize had no significant effects on soil bacterial community structure. The study can provide a theoretical basis to evaluate the safety of transgenic maize with cry1Ie gene.

  7. Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration.

    Science.gov (United States)

    Abo, Yao; Zannou Djimon, Marcel; Messou, Eugène; Balestre, Eric; Kouakou, Martial; Akakpo, Jocelyn; Ahouada, Carin; de Rekeneire, Nathalie; Dabis, François; Lewden, Charlotte; Minga, Albert

    2015-04-09

    The causes of severe morbidity in health facilities implementing Antiretroviral Treatment (ART) programmes are poorly documented in sub-Saharan Africa. We aimed to describe severe morbidity among HIV-infected patients after ART initiation, based on data from an active surveillance system established within a network of specialized care facilities in West African cities. Within the International epidemiological Database to Evaluate AIDS (IeDEA)--West Africa collaboration, we conducted a prospective, multicenter data collection that involved two facilities in Abidjan, Côte d'Ivoire and one in Cotonou, Benin. Among HIV-infected adults receiving ART, events were recorded using a standardized form. A simple case-definition of severe morbidity (death, hospitalization, fever>38°5C, Karnofsky indexART in ambulatory HIV care facilities in West Africa. Meanwhile, additional studies are needed due to the undiagnosed aspect of severe morbidity in substantial proportion.

  8. Numerical Analysis of the Risk of Neck Injuries Caused By IED Explosion under the Vehicle in Military Environments

    Directory of Open Access Journals (Sweden)

    Mackiewicz Agnieszka

    2016-12-01

    Full Text Available As a result of an explosion under a military vehicle, the risk of threat to life and health of the crew increases. Examination of this event in terms of the security of soldiers comes down to a complex analysis of the mutual interaction of the body of a soldier, seating and structural elements of the vehicle. As a result, shock wave impacts can cause tremor resulting from the construction of the vehicle and acceleration of the passenger's body. This study attempts to analyze the impact of an explosion of an improvised explosive device (IED under the military vehicle with the risk of cervical spine injuries of soldiers. The analysis was carried out using numerical methods in the LS-DYNA program and was carried out taking into account the variable displacement values and acceleration recorded during the\\ explosion. The study used a model of the body of a soldier in the form of a Hybrid III 50th Male Dummy.

  9. Inciting Striving Speech (i.e., BS and Imperfect Dialogical Exchanges is exactly what is needed in Higher Education Today

    Directory of Open Access Journals (Sweden)

    James Carifio

    2008-01-01

    Full Text Available Harry Frankfurt, the American moral philosopher, as well as his many advocates, has initiated a growing movement for eliminating BS from our culture and classrooms. BS is defined as people speaking beyond themselves on some topic that exceed their knowledge of the facts that are relevant to that topic. This article argues that BS and BS-ing (i.e., striving speech and imperfect dialogical exchanges are key and critical components to both social and intellectual development and that both are something that we want to increase in higher education right now as opposed to the current and past misguided efforts to eliminate them. A variety of current empirical studies and current learning and development theories are reviewed to support this view and recommendations are given to help professors facilitate and encourage striving speech and dialogue among students.

  10. Isolation of circulating tumor cells by immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS) for molecular profiling.

    Science.gov (United States)

    Magbanua, Mark Jesus M; Park, John W

    2013-12-01

    Circulating tumor cells (CTCs) are cells shed by the primary tumor into the blood stream capable of initiating distant metastasis. In the past decade, numerous assays have been developed to reliably detect these extremely rare cells. However, methods for purification of CTCs with little or no contamination of normal blood cells for molecular profiling are limited. We have developed a novel protocol to isolate CTCs by combining immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS). The two-part assay includes (1) immunomagnetic capture using magnetic beads conjugated to monoclonal antibody against an epithelial cell adhesion marker (EpCAM) to enrich for tumor cells; and (2) FACS analysis using EpCAM to purify tumor cells away from mononuclear cells of hematopoietic lineage. Downstream molecular analyses of single and pooled cells confirmed the isolation of highly pure CTCs with characteristics typical that of malignant cells.

  11. MIGRAȚIE SAU EXOD? EUROPA NOILOR VENIȚI ȘI PROVOCĂRILE ECONOMIEI SOCIALE

    Directory of Open Access Journals (Sweden)

    GHEORGHE TEODORESCU

    2015-11-01

    Full Text Available Valul migaţionist care a invadat ţărmul mediteraneean al Uniunii Europeneîn vara-toamna lui 2015, a declanşat o criză de proporţii nemaiîntâlnite până acum de Bruxelles. Ea pune în discuţie însăşi identitatea civilizaţiei europene, ameninţând să reinflameze conduite de tip xenofob şi rasial, considerate deja apuse în noua „Casa Europei”. Pentru a înţelege resorturile şi sursele care o alimentează, recursul la metodă constituie calea evitării unor excese şi inadecvate politici de contracarare a unui fenomen de o asemenea complexitate care dă semne că va dura încă şi în anii următori. Ca atare, distincţia între concepte bine definite ale sociologiei, economiei şi psihologiei sociale, ale culturii şi geopoliticii, nu este o simplă pedanterie academică, cât mai degrabă o modalitate de prudentă raportare la o situaţie cu multe elemente de incertitudine şi semne de întrebare. Le poate da un răspuns adecvat, fie şi parţial, economia socială?

  12. DIAGNÓSTICO DE LAS CONCEPCIONES SOBRE REPRODUCCIÓN CELULAR EN ESTUDIANTES DE GRADO SÉPTIMO, OCTAVO Y NOVENO DE LOS COLEGIOS MIGUEL ANTONIO CARO IED Y JUSTO VÍCTOR CHARRY IED

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Pineda Amórtegui

    2016-10-01

    Full Text Available El siguiente artículo da cuenta de los resultados obtenidos de la aplicación de una evaluación diagnóstica sobre reproducción celular en estudiantes de grado séptimo, octavo y noveno de los colegios Miguel Antonio Caro IED y Justo Víctor Charry IED, jornada tarde. El manejo de estos conceptos es primordial para que los estudiantes lleguen a comprender otras temáticas importantes dentro de la biología como lo son la genética, al entender los procesos de transmisión de caracteres hereditarios; la evolución de los seres vivos desde la variabilidad, la selección natural y la preservación de las especies; y en la biología del desarrollo, al reconocer la mitosis como proceso para la formación de un nuevo ser a partir de divisiones sucesivas de las células; entre otros. Este es un trabajo de investigación mixta, a través de la aplicación de un cuestionario con preguntas de selección múltiple con única respuesta, acompañado de una entrevista. El análisis de resultados se realizó con relación a número de aciertos, porcentajes de acierto, porcentajes de selección de respuesta y competencias desarrolladas, lo que permitió identificar las bases conceptuales y/o dificultades de los estudiantes frente a la comprensión y aprendizaje de los conceptos relacionados con la reproducción celular, y las falencias en cuanto al desarrollo de competencias en ciencias naturales que le permitan a los estudiantes conocer y actuar con relación a su entorno. Así mismo, se sugiere la planeación y diseño de una estrategia de enseñanza-aprendizaje-evaluación, la cual tome en cuenta las características y necesidades de la población a la que va dirigida, y decida sobre los contenidos a incluir.

  13. Protection of Occupants Military Vehicles Against Mine Threats and Improvised Explosive Devices (IED / Ochrona Załogi Pojazdu Wojskowego Przed Wybuchem Min i Improwizowanych Urządzeń Wybuchowych (IED

    Directory of Open Access Journals (Sweden)

    Sławiński Grzegorz

    2015-09-01

    Full Text Available W wyniku eksplozji pod pojazdem militarnym wzrasta ryzyko zagrożenia życia i zdrowia załogi. Rozpatrywanie tego zdarzenia pod kątem bezpieczeństwa żołnierzy sprowadza się do złożonej analizy wzajemnych oddziaływań ciała żołnierza, siedziska i elementów konstrukcji pojazdu. W efekcie działania fali uderzeniowej występują oddziaływania powodujące drgania wynikające z wibracji konstrukcji oraz przyspieszenie ciała pasażera. W pracy podjęto próbę analizy wpływu eksplozji improwizowanego ładunku wybuchowego (IED pod pojazdem militarnym na ryzyko powstania urazów kręgosłupa szyjnego żołnierzy. Analiza została wykonana z wykorzystaniem metod numerycznych w programie LS-DYNA i prowadzona była uwzględniając zmienne wartości przemieszczenia oraz przyspieszenia rejestrowane podczas wybuchu.

  14. Preventing Alkyne-Alkyne (i.e., Glaser) Coupling Associated with the ATRP Synthesis of Alkyne-Functional Polymers/Macromonomers and for Alkynes under Click (i.e., CuAAC) Reaction Conditions.

    Science.gov (United States)

    Leophairatana, Porakrit; Samanta, Sanjoy; De Silva, Chathuranga C; Koberstein, Jeffrey T

    2017-03-15

    Alkyne-functional polymers synthesized by ATRP exhibit bimodal molecular weight distributions indicating the occurrence of some undesirable side reaction. By modeling the molecular weight distributions obtained under various reaction conditions, we show that the side reaction is alkyne-alkyne (i.e., Glaser) coupling. Glaser coupling accounts for as much as 20% of the polymer produced, significantly compromising the polymer functionality and undermining the success of subsequent click reactions in which they are used. Glaser coupling does not occur during ATRP but during postpolymerization workup upon first exposure to air. Two strategies are reported that effectively eliminate these coupling reactions without the need for a protecting group for the alkyne-functional initiator: (1) maintaining low temperature post-ATRP upon exposure to air followed by immediate removal of copper catalyst; (2) adding excess reducing agents post-ATRP which prevent the oxidation of Cu(I) catalyst required by the Glaser coupling mechanism. Post-ATRP Glaser coupling was also influenced by the ATRP synthesis ligand used. The order of ligand activity for catalyzing Glaser coupling was: linear bidentate > tridentate > tetradentate. We find that Glaser coupling is not problematic in ARGET-ATRP of alkyne-terminated polymers because a reducing agent is present during polymerization, however the molecular weight distribution is broadened compared to ATRP due to the presence of oxygen. Glaser coupling can also occur for alkynes held under CuAAC reaction conditions but again can be eliminated by adding appropriate reducing agents.

  15. Altered ischemic cerebral injury in mice lacking αIE subunit of the voltage-dependent Ca2+ channel

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective ①To set up a stable and reproducible focal cerebral infarct modelin mice; (②To examine theinvolvement of αIE subunit of voltage-dependent Ca2 + channel in cerebral ischemic injury. Methods Male C57BL/6J Jclmice 8 ~ 12w and F4 ~ F6αIE subunit of Ca2+ channel mutant mice were both used in this study. All animals were allowedto freely access to food and water before and after operation. Animals were anesthetized with pentobarbital sodium 60mg/kg,ip. Rectal temperature was continuously monitored before, during and after operation, and maintained at (36.6 +0.1 )°C by a autoregulating pad. To produce pilot models, the middle cerebral artery (MCA) was occluded either by sur-gical ligation or electrical coagulation and in some models the common carotid artery (CCA) was surgically ligated in tan-dem. In our latter work the MCA was cut off soon after it was ligated or coagulated in order to make sure that the bloodflow was occluded completely. The MCA was coagulated or ligated with a bipolar coagulator or microsurgery suture at thesite just superior to the rhinal fissure. Twenty~four hours after the operation, the mice were anesthetized and decapitated,then their brains were dissected from the skull and put into cold artificial brain spinal fluid as soon as possible. Lmm thickcoronal sections were cut by vibratome and stained with 2% 2,3,5-triphenyltetrazolium chloride (TTC) at 37°C for30min. Every section was photographed positively and the whole infarction volume was calculated by summing up the in-farction volumes of all sections by NIH Image System. Infarction ratio ( % ) was also calculated by the following fommula:(contralateral volume-ipsilateral undamaged volume)/contralateral volume × 100% to eliminate the influence of edema.In brief, the mutant mice were produced with gene targeting technique. F4 ~ F6 mice were used in this experiment. Alloffsprings were genotyped by the polymerase chain reaction (PCR) and the genotypes remained umknown

  16. EXTEND OPERATION PROBLEMS AND RECONSTRUCTION OF LARGEPANEL FIVE-STOREY BUILDINGS OF 50-60-IES XX CENTURY

    Directory of Open Access Journals (Sweden)

    BOLSHAKOV V. I.,

    2016-01-01

    Full Text Available Raising of the problem. In many regions is utilised housing, that age is more than half a century. According to the research materials of the analytical center of Ukrainian Cities Association there are 25,5 thousand houses built by first mass series project of large, block and brick buildings with a total area of 72 million M2 today in the state, rather those, that require reconstruction and modernization. In general, most of the housing stock of Ukraine is in a poor technical condition due to its deficient funding; it keeps the tendency of premature aging of the housing stock.One of the major problems of modern construction industry is the continuation of housing exploitation, in particular is it the building era of mass construction of 50-60-ies of XX century, called "Khrushchevki". According to the State Statistics Service of Ukraine the deterioration of residential buildings in Ukraine amounts to 47.2%, which makes us think of the immediate actions to occure this situation. The most acceptable way, at first viewe, seems the reconstruction of "Khrushchvki". However, the reconstruction is a complex problem that requires the construction industry solution due to the economic component, the social factor, the views of residents of these homes to create a technological and economical viable result. Analysis of publications. The problem of the "Khrushchevki" reconstruction is the subject of continual researches of leading builders of Ukraine. In the researchers' attention just as the technological problems [1 - 3], so economic components [4 - 6], in general, give an idea of the work scale required to overcome the impending crisis. The purpose of the article. Defining the main problems of exploatation of panel fivestory buildings of 50 - 60-ies twentieth century and their residents thoughts about existing inconvenience, as well as associated economic, technological and legal problems in the implementation of buildings reconstruction. Conclusions

  17. [Advances in molecular mechanisms of adaptive immunity mediated by type I-E CRISPR/Cas system--A review].

    Science.gov (United States)

    Sun, Dongchang; Qiu, Juanping

    2016-01-01

    To better adapt to the environment, prokaryocyte can take up exogenous genes (from bacteriophages, plasmids or genomes of other species) through horizontal gene transfer. Accompanied by the acquisition of exogenous genes, prokaryocyte is challenged by the invasion of 'selfish genes'. Therefore, to protect against the risk of gene transfer, prokaryocyte needs to establish mechanisms for selectively taking up or degrading exogenous DNA. In recent years, researchers discovered an adaptive immunity, which is mediated by the small RNA guided DNA degradation, prevents the invasion of exogenous genes in prokaryocyte. During the immune process, partial DNA fragments are firstly integrated.to the clustered regularly interspaced short palindromic repeats (CRISPR) located within the genome DNA, and then the mature CRISPR RNA transcript and the CRISPR associated proteins (Cas) form a complex CRISPR/Cas for degrading exogenous DNA. In this review, we will first briefly describe the CRISPR/Cas systems and then mainly focus on the recent advances of the function mechanism and the regulation mechanism of the type I-E CRISPR/Cas system in Escherichia coli.

  18. Los Departamentos de Orientación en los IES : Estudio de las disociaciones entre percepciones reales y normativa legal

    Directory of Open Access Journals (Sweden)

    Rufino Cano González

    2013-05-01

    Full Text Available El hecho de que estemos a punto de cumplir los diez primeros años de implantación de la LOGSE, es motivo más que suficiente para reflexionar, desde la teoría, y evaluar, desde la práctica, su mutua corresponsabilidad en uno de los ámbitos de la estructura organizativa de los IES especialmente cuidado, como es el caso de los Departamentos de Orientación. Nuestro objetivo, pues, es evaluar la posible conjunción o disociación del binomio, teoría-práctica, mediante un análisis comparativo entre lo prescrito en la normativa legal promulgada por la Administración Pública y lo descrito y percibido a través de las experiencias de Orientación que se vienen desarrollando en los Institutos de Enseñanza Secundaria de Valladolid y provincia, con la intención última de formular propuestas y recomendaciones de mejora basadas en los resultados del estudio que hemos realizado.

  19. RNA reprogramming of alpha-mannosidase mRNA sequences in vitro by myxomycete group IC1 and IE ribozymes.

    Science.gov (United States)

    Fiskaa, Tonje; Lundblad, Eirik W; Henriksen, Jørn R; Johansen, Steinar D; Einvik, Christer

    2006-06-01

    Trans-splicing group I ribozymes have been introduced in order to mediate RNA reprogramming (including RNA repair) of therapeutically relevant RNA transcripts. Efficient RNA reprogramming depends on the appropriate efficiency of the reaction, and several attempts, including optimization of target recognition and ribozyme catalysis, have been performed. In most studies, the Tetrahymena group IC1 ribozyme has been applied. Here we investigate the potential of group IC1 and group IE intron ribozymes, derived from the myxomycetes Didymium and Fuligo, in addition to the Tetrahymena ribozyme, for RNA reprogramming of a mutated alpha-mannosidase mRNA sequence. Randomized internal guide sequences were introduced for all four ribozymes and used to select accessible sites within isolated mutant alpha-mannosidase mRNA from mammalian COS-7 cells. Two accessible sites common to all the group I ribozymes were identified and further investigated in RNA reprogramming by trans-splicing analyses. All the myxomycete ribozymes performed the trans-splicing reaction with high fidelity, resulting in the conversion of mutated alpha-mannosidase RNA into wild-type sequence. RNA protection analysis revealed that the myxomycete ribozymes perform trans-splicing at approximately similar efficiencies as the Tetrahymena ribozyme. Interestingly, the relative efficiency among the ribozymes tested correlates with structural features of the P4-P6-folding domain, consistent with the fact that efficient folding is essential for group I intron trans-splicing.

  20. Thermal and Physical Property Determinations for Ionsiv IE-911 Crystalline Silicotitanate and Savannah River Site Waste Simulant Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Bostick, D.T.; Steele, W.V.

    1999-08-01

    This document describes physical and thermophysical property determinations that were made in order to resolve questions associated with the decontamination of Savannah River Site (SRS) waste streams using ion exchange on crystalline silicotitanate (CST). The research will aid in the understanding of potential issues associated with cooling of feed streams within SRS waste treatment processes. Toward this end, the thermophysical properties of engineered CST, manufactured under the trade name, Ionsive{reg_sign} IE-911 by UOP, Mobile, AL, were determined. The heating profiles of CST samples from several manufacturers' production runs were observed using differential scanning calorimetric (DSC) measurements. DSC data were obtained over the region of 10 to 215 C to check for the possibility of a phase transition or any other enthalpic event in that temperature region. Finally, the heat capacity, thermal conductivity, density, viscosity, and salting-out point were determined for SRS waste simulants designated as Average, High NO{sub 3}{sup {minus}} and High OH{sup {minus}} simulants.

  1. Between “spiritual empowerment” and the “eco-spirituality”: a study of Seicho-no-Ie do Brasil

    Directory of Open Access Journals (Sweden)

    João Paulo de Paula Silveira

    2016-09-01

    Full Text Available This paper investigates contemporary nuances of the religious identity of supporters of Seicho-no-Ie (House of Growth in English. It considers two conspicuous aspects of this identity: "spiritual empowerment" and eco-spirituality. Both are perceived as consequences of the impact of late modernity on the religious imagination of contemporary woman and man. The data we used were collected from the Seicho-no-Ie’s supporters of the city of Goiania, State of Goiás, in 2015, and from religious publications with which we had contact. This study is congruous with the discussions that understand new religions and spiritualties as responses to modern social and cultural contingencies, in particular the approaches of Lorne L. Dawson (2004; 2006 and Christopher Partridge (2005. Both of these authors draw attention to the importance of sociological understanding of the new religions and alternative spiritualities as a specific phenomenon of contemporaneity that should not be reduced to comprehensive schemes that trivialize this kind of religious sensitivity.

  2. RAISING COOPERATION AMONG FARM HOLDINGS AND AGROINDUSTRIAL INTEGRATION IN FARM PRODUCTION OF THE KUBAN REGION IN THE 1970-IES

    Directory of Open Access Journals (Sweden)

    Sergey Nikolaevich Chernikov

    2015-01-01

    Full Text Available The paper stated that in Russia nowadays high priority is attached to farming’ advancement, due to the necessity to ensure food security nationwide. The country accumulated an extensive experience in the sector of industrial farming; that experience may be qualified as both positive and negative, being instructive in many respects. On the one part, this experience evidently demonstrated that the total control being highly destructive, as well as petty regulation, and practicing transfer of private farm holdings into State ownership. On the other part, using the State regulation machinery in the farming sector reflected one of the leading trends in the farming sector advancement round the world nowadays, namely: strengthening the part taken by the State in advancement of the industrial farming sector. In this regard, experience accumulated in the policy of farming sector over the period of Soviet State being both conceptually and pragmatically significant for determining the most efficient ways of industrial farming sector’ advancement. The paper reviewed raising cooperation among the farm holdings and agro-industrial integration in farm production of the Kuban Region in the 1970-ies with the purpose of increasing production and processing of farm products.

  3. Synthesis of PE with Broad MWD Catalyzed by Supported Ziegler-Natta Catalyst Consisting of Cycloalkoxy Silane as IED

    Institute of Scientific and Technical Information of China (English)

    Yu Mengshan; Nie Yanpei; Zhou Lu; Yi Jianjun; Huang Qigu; Gao Kejing; Yang Wantai

    2014-01-01

    Two kinds of cycloalkoxy silane compounds were synthesized and used as the internal electron donors (IEDs) of supported Ziegler-Natta catalyst for ethylene polymerization to produce polyethylene with broader molecular weight distribution (MWD). The effect of the structure and the amount of these IEDs on the polymerization performance was in-vestigated. The results implied that the molecular weight distribution of the obtained polyethylene could be adjusted by the incorporation of IEDs. SEM result showed that the morphology of catalyst particle was spherical and uniform in size distribution. The titanium content of these catalysts was higher, the active TiCl4 species were easily anchored on the support than that without adding IED, which was determined by ICP. The GPC result conifrmed that the polyethylene with broader molecular weight distribution in the range of from 23.4 to 25.6 was obtained using triethoxy-(-cyclopentyloxy)-silane (ED1) and triethoxy-(-cyclohexyloxyl)-silane (ED2) as the internal electron donors.

  4. Desenvolvimento de liderança e equipes para representantes de turma de uma IES de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    David Ferreira Bomfin

    2010-10-01

    Full Text Available Preparar representantes de turma para exercerem suas atividades utilizando habilidades de liderança e trabalho em equipe é o foco desta pesquisa. A primeira etapa, aqui relatada, analisou a percepção que representantes de turma têm do significado de liderança e equipes para seu desempenho atual e para sua atividade profissional futura. A segunda etapa, a ser desenvolvida, consistirá na adoção de estratégias de ensino capazes de prepará-los para exercerem liderança e participarem produtivamente de equipes. Trata-se de um estudo de caso desenvolvido numa instituição de ensino superior - IES privada, em Belo Horizonte, com 91 sujeitos: 78 representantes de turma de diversos cursos da instituição e 13 suplentes. Foi aplicado um questionário eletrônico, que foi submetido a uma análise quantitativa e qualitativa. Os resultados indicam que os pesquisados consideram relevante o preparo para a liderança e o trabalho com equipes tanto para o representante de turma quanto para sua vida profissional futura. As competências que os pesquisados consideram importantes para serem desenvolvidas pelo representante de turma foram: postura ética e comprometida com os colegas; capacidade de comunicação efetiva e diálogo; estimular a participação dos colegas nos assuntos de interesse comum da turma; promover a integração e a reflexão crítica do curso; intervir em conflitos, ouvir os pares, identificar suas necessidades e encaminhar o consenso. A pesquisa deverá ter continuidade numa etapa através da qual se espera desenvolver as competências identificadas mediante minicursos devidamente articulados com as atividades extracurriculares e coerentes com o projeto pedagógico.

  5. Preparation and Characterization of HLA-A*0201 Tetramer Loaded with IE-1316-324 Antigenic Peptide of Human Cytomegalovirus

    Institute of Scientific and Technical Information of China (English)

    Lihui Xu; Qingbing Zha; Hong Sun; Qiantao Jia; Fengyao Li; Xianhui He

    2006-01-01

    Major histocompatibility complex (MHC) class Ⅰ tetramer technology has become the central technique for analyzing antigen-specific CD8+ T cell responses and it has been widely used to explore the differentiation and formation of memory CD8+ T cells. Previously, a simplified and efficient procedure for preparing high quality HLA-A*0201 tetramers has been established in our lab and the tetramers loaded with HCMV peptide pp65495-503has been successfully applied to investigate HCMV-specific CD8+ T cells in Chinese populations. Using similar procedure we reported here the construction of HLA-A*0201 tetramer loaded with another dominant epitope derived from immediate early (IE)-1316-324 (VLEETSVML, VLE) of HCMV (A2-VLE) and characterization of this tetramer. After A2-VLE monomer was prepared and purified, its tetramer was then formed at a yield of 83%. The optimized amount of A2-VLE tetramer for staining 100 μl whole blood was 0.5 μg with incubation at 4℃ for 1 h.Furthermore, the dissociation constant of the tetramer binding to the specific CD8+ T cells of one HLA-A2+ donor was estimated to be 32.7 nmol/L, which is markedly higher than that of MHC monomer. The construction of A2-VLE tetramer provides an alternative choice for investigating HCMV-specific CD8+ T cell responses and will deepen our understanding of the differentiation and formation of HCMV-specific memory CD8+ T cells.

  6. Conserved structural motifs at the C-terminus of baculovirus protein IE0 are important for its functions in transactivation and supporting hr5-mediated DNA replication.

    Science.gov (United States)

    Luria, Neta; Lu, Liqun; Chejanovsky, Nor

    2012-05-01

    IE0 and IE1 are transactivator proteins of the most studied baculovirus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV). IE0 is a 72.6 kDa protein identical to IE1 with the exception of its 54 N-terminal amino acid residues. To gain some insight about important structural motifs of IE0, we expressed the protein and C‑terminal mutants of it under the control of the Drosophila heat shock promoter and studied the transactivation and replication functions of the transiently expressed proteins. IE0 was able to promote replication of a plasmid bearing the hr5 origin of replication of AcMNPV in transient transfections with a battery of eight plasmids expressing the AcMNPV genes dnapol, helicase, lef-1, lef-2, lef-3, p35, ie-2 and lef-7. IE0 transactivated expression of the baculovirus 39K promoter. Both functions of replication and transactivation were lost after introduction of selected mutations at the basic domain II and helix-loop-helix conserved structural motifs in the C-terminus of the protein. These IE0 mutants were unable to translocate to the cell nucleus. Our results point out the important role of some structural conserved motifs to the proper functioning of IE0.

  7. Conserved Structural Motifs at the C-Terminus of Baculovirus Protein IE0 are Important for its Functions in Transactivation and Supporting hr5-mediated DNA Replication

    Directory of Open Access Journals (Sweden)

    Neta Luria

    2012-05-01

    Full Text Available IE0 and IE1 are transactivator proteins of the most studied baculovirus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV. IE0 is a 72.6 kDa protein identical to IE1 with the exception of its 54 N-terminal amino acid residues. To gain some insight about important structural motifs of IE0, we expressed the protein and C‑terminal mutants of it under the control of the Drosophila heat shock promoter and studied the transactivation and replication functions of the transiently expressed proteins. IE0 was able to promote replication of a plasmid bearing the hr5 origin of replication of AcMNPV in transient transfections with a battery of eight plasmids expressing the AcMNPV genes dnapol, helicase, lef-1, lef-2, lef-3, p35, ie-2 and lef-7. IE0 transactivated expression of the baculovirus 39K promoter. Both functions of replication and transactivation were lost after introduction of selected mutations at the basic domain II and helix-loop-helix conserved structural motifs in the C-terminus of the protein. These IE0 mutants were unable to translocate to the cell nucleus. Our results point out the important role of some structural conserved motifs to the proper functioning of IE0.

  8. Adult HIV care resources, management practices and patient characteristics in the Phase 1 IeDEA Central Africa cohort

    Directory of Open Access Journals (Sweden)

    Jules Mushingantahe

    2012-11-01

    Full Text Available Introduction: Despite recent advances in the management of HIV infection and increased access to treatment, prevention, care and support, the HIV/AIDS epidemic continues to be a major global health problem, with sub-Saharan Africa suffering by far the greatest humanitarian, demographic and socio-economic burden of the epidemic. Information on HIV/AIDS clinical care and established cohorts’ characteristics in the Central Africa region are sparse. Methods: A survey of clinical care resources, management practices and patient characteristics was undertaken among 12 adult HIV care sites in four countries of the International Epidemiologic Databases to Evaluate AIDS Central Africa (IeDEA-CA Phase 1 regional network in October 2009. These facilities served predominantly urban populations and offered primary care in the Democratic Republic of Congo (DRC; six sites, secondary care in Rwanda (two sites and tertiary care in Cameroon (three sites and Burundi (one site. Results: Despite some variation in facility characteristics, sites reported high levels of monitoring resources, including electronic databases, as well as linkages to prevention of mother-to-child HIV transmission programs. At the time of the survey, there were 21,599 HIV-positive adults (median age=37 years enrolled in the clinical cohort. Though two-thirds were women, few adults (6.5% entered HIV care through prevention of mother-to-child transmission services, whereas 55% of the cohort entered care through voluntary counselling and testing. Two-thirds of patients at sites in Cameroon and DRC were in WHO Stage III and IV at baseline, whereas nearly all patients in the Rwanda facilities with clinical stage information available were in Stage I and II. WHO criteria were used for antiretroviral therapy initiation. The most common treatment regimen was stavudine/lamivudine/nevirapine (64%, followed by zidovudine/lamivudine/nevirapine (19%. Conclusions: Our findings demonstrate the

  9. The growth-form of Euphorbia hedyotoides N. E. Br. (syn. <i>E. decariana Croiz.

    Directory of Open Access Journals (Sweden)

    Rauh, Werner

    1992-12-01

    Full Text Available A detailed description is given or Euphorbia hedyotoides N. E. Or. from southern Madagascar with a peculiar growth-form. Together with <i>E. eliotii Léandri it is placed in a separate group: the <i>E. hedyotoides-group.

    S'ofereix una detallada descripció d'una peculiar forma de creixement d'E. hedyotoides N. E. Or. procedent del sud de Madagascar. Es situa,juntament amb <i>E. eliotii Léandri, en un grup separat : el grup <i>E. hedyotoides.

  10. The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation.

    Science.gov (United States)

    Schilling, Eva-Maria; Scherer, Myriam; Reuter, Nina; Schweininger, Johannes; Muller, Yves A; Stamminger, Thomas

    2017-02-15

    PML nuclear bodies (NBs) are accumulations of cellular proteins embedded in a scaffold-like structure built by SUMO-modified PML/TRIM19. PML and other NB proteins act as cellular restriction factors against human cytomegalovirus (HCMV); however, this intrinsic defense is counteracted by the immediate early protein 1 (IE1) of HCMV. IE1 directly interacts with the PML coiled-coil domain via its globular core region and disrupts NB foci by inducing a loss of PML SUMOylation. Here, we demonstrate that IE1 acts via abrogating the de novo SUMOylation of PML. In order to overcome reversible SUMOylation dynamics, we made use of a cell-based assay that combines inducible IE1 expression with a SUMO mutant resistant to SUMO proteases. Interestingly, we observed that IE1 expression did not affect preSUMOylated PML; however, it clearly prevented de novo SUMO conjugation. Consistent results were obtained by in vitro SUMOylation assays, demonstrating that IE1 alone is sufficient for this effect. Furthermore, IE1 acts in a selective manner, since K160 was identified as the main target lysine. This is strengthened by the fact that IE1 also prevents As2O3-mediated hyperSUMOylation of K160, thereby blocking PML degradation. Since IE1 did not interfere with coiled-coil-mediated PML dimerization, we propose that IE1 affects PML autoSUMOylation either by directly abrogating PML E3 ligase function or by preventing access to SUMO sites. Thus, our data suggest a novel mechanism for how a viral protein counteracts a cellular restriction factor by selectively preventing the de novo SUMOylation at specific lysine residues without affecting global protein SUMOylation. The human cytomegalovirus IE1 protein acts as an important antagonist of a cellular restriction mechanism that is mediated by subnuclear structures termed PML nuclear bodies. This function of IE1 is required for efficient viral replication and thus constitutes a potential target for antiviral strategies. In this paper, we further

  11. IE 7.0,更高的安全性:Beta 1版本包含了新的安全特性预览

    Institute of Scientific and Technical Information of China (English)

    Jeff; Fellinge; 肖欣(译)

    2006-01-01

    IE 6.0的安全漏洞不断被发现,其它浏览器正在蚕食IE的市场,微软会采取什么措施来挽回局面呢?答案是IE7.0。微软在IE 7.0中注入了大量的心血,在安全方面加入了安全报告、Phishing过滤器等新的特性。目前IE7.0 Beta1已经发布,还等什么呢?快去下载来体验IE7.0的新功能吧。IE6.0的安全漏洞不断被发现,其它浏览器正在蚕食IE的市场,微软会采取什么措施来挽回局面呢?答案是IE7.0。微软在IE7.0中注入了大量的心血,在安全方面加入了安全报告、Phishing过滤器等新的特性。目前IE7.0 Beta1已经发布,还等什么呢?快去下载来体验IE7.0的新功能吧。

  12. The exchangeability study of digital substation intelligent electrical devices (IED)%数字化变电站IED互换性研究

    Institute of Scientific and Technical Information of China (English)

    罗建; 钟加勇; 黄益华; 马泽菊

    2011-01-01

    Limited by the data model configuration technology of the smart device, IED exchangeability of digital substation has not been achieved.Following the IEC61850 communication system, this paper proposes resource definition mechanism and resource matching mechanism based on demand incentives, and divides the resource of IED into production resource object and demand resource object.The definition mechanism, considering the IED topology, achieves the automatic configuration of substation intelligent devices data model.Through the semantic description of production resource objects, the internal differences in IED are shielded.Through the mechanism, the resources of IED can achieve the definition, activation, search, association, transaction and connection, thus IED exchangeability in the digital substation is realized.%受智能设备数据模型配置技术的限制,数字化变电站智能电子设备互换性还未能实现.在不改变 IEC61850 通信标准体系的前提下,提出了资源定义机制和基于需求激励的资源匹配机制,将 IED 的资源分为需求资源对象和生产资源对象.该定义机制在考虑 IED 拓扑关系的基础上,实现了变电站智能设备数据模型的自动配置,通过生产资源对象带语义的描述,屏蔽了 IED 内部的差异;通过该机制实现对 IED 资源的定义、激活、寻找、关联,交易和连接,以达到在数字化变电站内 IED间互换性的实现.

  13. Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.

    Science.gov (United States)

    Ote, Isabelle; Lebrun, Marielle; Vandevenne, Patricia; Bontems, Sébastien; Medina-Palazon, Cahora; Manet, Evelyne; Piette, Jacques; Sadzot-Delvaux, Catherine

    2009-11-18

    Available data suggest that the Varicella-Zoster virus (VZV) IE4 protein acts as an important regulator on VZV and cellular genes expression and could exert its functions at post-transcriptional level. However, the molecular mechanisms supported by this protein are not yet fully characterized. In the present study, we have attempted to clarify this IE4-mediated gene regulation and identify some cellular partners of IE4. By yeast two-hybrid and immunoprecipitation analysis, we showed that IE4 interacts with three shuttling SR proteins, namely ASF/SF2, 9G8 and SRp20. We positioned the binding domain in the IE4 RbRc region and we showed that these interactions are not bridged by RNA. We demonstrated also that IE4 strongly interacts with the main SR protein kinase, SRPK1, and is phosphorylated in in vitro kinase assay on residue Ser-136 contained in the Rb domain. By Northwestern analysis, we showed that IE4 is able to bind RNA through its arginine-rich region and in immunoprecipitation experiments the presence of RNA stabilizes complexes containing IE4 and the cellular export factors TAP/NXF1 and Aly/REF since the interactions are RNase-sensitive. Finally, we determined that IE4 influences the export of reporter mRNAs and clearly showed, by TAP/NXF1 knockdown, that VZV infection requires the TAP/NXF1 export pathway to express some viral transcripts. We thus highlighted a new example of viral mRNA export factor and proposed a model of IE4-mediated viral mRNAs export.

  14. Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.

    Directory of Open Access Journals (Sweden)

    Isabelle Ote

    Full Text Available Available data suggest that the Varicella-Zoster virus (VZV IE4 protein acts as an important regulator on VZV and cellular genes expression and could exert its functions at post-transcriptional level. However, the molecular mechanisms supported by this protein are not yet fully characterized. In the present study, we have attempted to clarify this IE4-mediated gene regulation and identify some cellular partners of IE4. By yeast two-hybrid and immunoprecipitation analysis, we showed that IE4 interacts with three shuttling SR proteins, namely ASF/SF2, 9G8 and SRp20. We positioned the binding domain in the IE4 RbRc region and we showed that these interactions are not bridged by RNA. We demonstrated also that IE4 strongly interacts with the main SR protein kinase, SRPK1, and is phosphorylated in in vitro kinase assay on residue Ser-136 contained in the Rb domain. By Northwestern analysis, we showed that IE4 is able to bind RNA through its arginine-rich region and in immunoprecipitation experiments the presence of RNA stabilizes complexes containing IE4 and the cellular export factors TAP/NXF1 and Aly/REF since the interactions are RNase-sensitive. Finally, we determined that IE4 influences the export of reporter mRNAs and clearly showed, by TAP/NXF1 knockdown, that VZV infection requires the TAP/NXF1 export pathway to express some viral transcripts. We thus highlighted a new example of viral mRNA export factor and proposed a model of IE4-mediated viral mRNAs export.

  15. WSSV ie1 promoter is more efficient than CMV promoter to express H5 hemagglutinin from influenza virus in baculovirus as a chicken vaccine

    Directory of Open Access Journals (Sweden)

    Yu Li

    2008-12-01

    Full Text Available Abstract Background The worldwide outbreak of influenza A (H5N1 viruses among poultry species and humans highlighted the need to develop efficacious and safe vaccines based on efficient and scaleable production. Results White spot syndrome virus (WSSV immediate-early promoter one (ie1 was shown to be a stronger promoter for gene expression in insect cells compared with Cytomegalovirus immediate-early (CMV promoter in luciferase assays. In an attempt to improve expression efficiency, a recombinant baculovirus was constructed expressing hemagglutinin (HA of H5N1 influenza virus under the control of WSSV ie1 promoter. HA expression in SF9 cells increased significantly with baculovirus under WSSV ie1 promoter, compared with CMV promoter based on HA contents and hemagglutination activity. Further, immunization with baculovirus under WSSV ie1 promoter in chickens elicited higher level anti-HA antibodies compared to CMV promoter, as indicated in hemagglutination inhibition, virus neutralization and enzyme-linked immunosorbent assays. By immunohistochemistry, strong HA antigen expression was observed in different chicken organs with vaccination of WSSV ie1 promoter controlled baculovirus, confirming higher efficiency in HA expression by WSSV ie1 promoter. Conclusion The production of H5 HA by baculovirus was enhanced with WSSV ie1 promoter, especially compared with CMV promoter. This contributed to effective elicitation of HA-specific antibody in vaccinated chickens. This study provides an alternative choice for baculovirus based vaccine production.

  16. 国际英语和我们的跨国公司(连载二)%IE and Our Multinational Company

    Institute of Scientific and Technical Information of China (English)

    良晨

    2005-01-01

    @@ An unexpected pleasure:"Nobody is infallible!" As you can see,my boss tends to be a perfectionist in the IE improving process. Being his Business Manager, I should certainly follow his good example.

  17. 11 CFR 300.52 - Fundraising by Federal candidates and Federal officeholders (2 U.S.C. 441i(e)(1)&(4)).

    Science.gov (United States)

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Fundraising by Federal candidates and Federal officeholders (2 U.S.C. 441i(e)(1)&(4)). 300.52 Section 300.52 Federal Elections FEDERAL ELECTION COMMISSION... Fundraising by Federal candidates and Federal officeholders (2 U.S.C. 441i(e)(1)&(4)). A Federal candidate,...

  18. Domain III of Bacillus thuringiensis Cry1Ie Toxin Plays an Important Role in Binding to Peritrophic Membrane of Asian Corn Borer

    Science.gov (United States)

    Feng, Dongmei; Chen, Zhen; Wang, Zhiwen; Zhang, Chunlu; He, Kanglai; Guo, Shuyuan

    2015-01-01

    The insecticidal IE648 toxin is a truncated Cry1Ie protein with increased toxicity against Asian corn borer (ACB). Cry toxins are pore-forming toxins that disrupt insect midgut cells to kill the larvae. However, the peritrophic membrane (PM) is an important barrier that Cry toxins must cross before binding to midgut cells. Previously, it was shown that Cry toxins are able to bind and accumulate in the PM of several lepidopteran insects. Binding of IE648 toxin to PM of ACB was previously reported and the goal of the current work was the identification of the binding region between Cry1Ie and the PM of ACB. Homologous competition binding assays showed that this interaction was specific. Heterologous competition binding assays performed with different fragments corresponding to domain I, domain II and domain III allowed us to identify that domain III participates in the interaction of IE648 with the PM. Specifically, peptide D3-L8 (corresponding to Cry1Ie toxin residues 607 to 616), located in an exposed loop region of domain III is probably involved in this interaction. Ligand blot assays show that IE648 interact with chitin and PM proteins with sizes of 30, 32 and 80 kDa. The fact that domain III interacts with proteins of similar molecular masses supports that this region of the toxin might be involved in PM interaction. These data provide for the first time the identification of domain III as a putative binding region between PM and 3D-Cry toxin. PMID:26295704

  19. Domain III of Bacillus thuringiensis Cry1Ie Toxin Plays an Important Role in Binding to Peritrophic Membrane of Asian Corn Borer.

    Directory of Open Access Journals (Sweden)

    Dongmei Feng

    Full Text Available The insecticidal IE648 toxin is a truncated Cry1Ie protein with increased toxicity against Asian corn borer (ACB. Cry toxins are pore-forming toxins that disrupt insect midgut cells to kill the larvae. However, the peritrophic membrane (PM is an important barrier that Cry toxins must cross before binding to midgut cells. Previously, it was shown that Cry toxins are able to bind and accumulate in the PM of several lepidopteran insects. Binding of IE648 toxin to PM of ACB was previously reported and the goal of the current work was the identification of the binding region between Cry1Ie and the PM of ACB. Homologous competition binding assays showed that this interaction was specific. Heterologous competition binding assays performed with different fragments corresponding to domain I, domain II and domain III allowed us to identify that domain III participates in the interaction of IE648 with the PM. Specifically, peptide D3-L8 (corresponding to Cry1Ie toxin residues 607 to 616, located in an exposed loop region of domain III is probably involved in this interaction. Ligand blot assays show that IE648 interact with chitin and PM proteins with sizes of 30, 32 and 80 kDa. The fact that domain III interacts with proteins of similar molecular masses supports that this region of the toxin might be involved in PM interaction. These data provide for the first time the identification of domain III as a putative binding region between PM and 3D-Cry toxin.

  20. POLÍTICAS E INCENTIVOS AO EMPREENDEDORISMO EM INSTITUIÇÕES DE ENSINO SUPERIOR (IES - UMA NOVA ABORDAGEM PARA A GESTÃO EDUCACIONAL

    Directory of Open Access Journals (Sweden)

    Günther Lother Pertschy

    2003-05-01

    Full Text Available RESUMO
    Este artigo aborda as principais bases do empreendedorismo, as características preponderantes do empreendedor e a relação desses últimos com as instituições de ensino superior (IES. Advogamos aqui o empreendedorismo, como uma vantagem competitiva quando bem desenvolvido por meio de políticas e incentivos de amplo espectro e de fontes diversas. Discutimos aqui um rol de políticas e diferentes formas de incentivo ao empreendedorismo em IES. Esta análise nos permite concluir que o desenvolvimento e expansão das IES, hoje, dependem mais de uma atitude empreendedora, ou um movimento empreendedor de dentro para fora, lastreado em parcerias devidamente planejadas, na excelência ou qualidade de seus produtos/serviços e na visão do negócio educacional como sustentação da educação, do que na simples racionalização de seus custos operacionais. Por fim, mostramos que atitude empreendedora traz vantagens competitivas inigualáveis para as IES, especialmente para as chamadas "Faculdades Integradas e Isoladas", mais ágeis, com estruturas enxutas e menos custosas.
    Palavras-chave:empreendedor; empreendedorismo; empreendedorismo e IES; políticas e empreendedorismo; incentivo ao empreendedorismo

  1. Ethesia tanquana (Ornithogaloideae, Hyacinthaceae, a new species from the Tanqua Karoo (South Africa, with notes on <i>E. haalenbergensis

    Directory of Open Access Journals (Sweden)

    Martínez-Azorín, Mario

    2012-12-01

    Full Text Available As a part of a taxonomic revision of Ethesia Raf., a new species, <i>E. tanquana Mart.-Azorín & M.B.Crespo, is described from the Tanqua Karoo in South Africa. This new species is at first sight similar to <i>E. haalenbergensis (U.Mu.ll.-Doblies & D.Mu.ll.-Doblies Mart.-Azorín, M.B.Crespo & Juan and also <i>E. xanthochlora (Baker Mart.-Azorín, M.B.Crespo & Juan, but it differs in floral and vegetative characters as well as in its ecology and isolated distribution. A complete description, data on biology, habitat, and distribution of the new species are presented. An identification key for Ethesia and new data on the rare Namibian <i>E. haalenbergensis are also given.

    En el marco de la revisión taxonómica de Ethesia Raf., se describe una nueva especie, <i>E. tanquana Mart.-Azorín & M.B.Crespo, del Tanqua Karoo en Sudáfrica. Esta nueva especie se asemeja a primera vista a <i>E. haalenbergensis (U.Mu.ll.-Doblies & D.Mu.ll.-Doblies Mart.-Azorín, M.B.Crespo & Juan y <i>E. xanthochlora (Baker Mart.-Azorín, M.B.Crespo & Juan, pero difiere por sus caracteres florales y vegetativos así como por su peculiar ecología y distribución aislada. Además, se presenta una descripción completa para la nueva especie, junto a información sobre su biología, hábitat, y distribución. Finalmente, se presenta una clave de identificación para Ethesia y nuevos datos sobre el raro endemismo namibiano <i>E. haalenbergensis.

  2. A COMPETÊNCIA INFORMACIONAL E SUA INFLUÊNCIA NA PERCEPÇÃO DE VARIÁVEIS ORGANIZACIONAIS ESTRATÉGICAS EM IES PRIVADAS

    Directory of Open Access Journals (Sweden)

    Ricardo Rodrigues Barbosa

    2012-10-01

    Full Text Available Atuando em um contexto extremamente dinâmico e de competição acirrada, as IES necessitam de informações que lhes permitam compreender as fortes mudanças ocorridas em seus ambientes nos últimos anos, assim como as tendências que prevalecem no seu setor. Neste sentido, o presente trabalho apresenta o resultado de uma pesquisa cujo objetivo foi explorar o relacionamento entre a competência informacional e a percepção dos ambientes organizacionais por parte de gestores de instituições privadas de ensino superior (IES. É um estudo qualitativo, realizado a partir da aplicação de um questionário a nove coordenadores de cursos de uma IES privada. O estudo identificou variáveis internas e externas percebidas pelos gestores desta IES como fatores de pressão em suas atividades e confrontou as variáveis percebidas com as variáveis de um ambiente padrão em que eles atuam. Identificou ainda os conhecimentos e habilidades que estes gestores consideram mais importantes para lidar com essas variáveis. O estudo confirma a complexidade informacional dos ambientes em que atuam estes gestores e realça a importância de programas formais de capacitação e conscientização sobre o papel da informação nas organizações.

  3. A randomised clinical trial of comprehensive cardiac rehabilitation versus usual care for patients treated for infective endocarditis--the CopenHeartIE trial protocol

    DEFF Research Database (Denmark)

    Rasmussen, Trine Bernholdt; Zwisler, Ann-Dorthe; Sibilitz, Kirstine Lærum;

    2012-01-01

    Infective endocarditis (IE) is among the most serious infectious diseases in the western world. Treatment requires lengthy hospitalisation, high-dosage antibiotic therapy and possible valve replacement surgery. Despite advances in treatment, the 1-year mortality remains at 20-40%. Studies indicat...

  4. Vector competence of Mexican and Honduran mosquitoes (Diptera: Culicidae) for enzootic (IE) and epizootic (IC) strains of Venezuelan equine encephalomyelitis virus.

    Science.gov (United States)

    Turell, Michael J; O'Guinn, Monica L; Navarro, Roberto; Romero, Guadeloupe; Estrada-Franco, José G

    2003-05-01

    Experimental studies evaluated the vector competence of Ochlerotatus taeniorhynchus (Wiedemann), Culex cancer Theobald, Culex pseudes (Dyar and Knab), Culex taeniopus Dyar and Knab, and a Culex (Culex) species, probably Culex quinquefasciatus Say, and Culex nigripalpus Theobald from Chiapas, Mexico, and Tocoa, Honduras, for epizootic (IC) and enzootic (IE) strains of Venezuelan equine encephalomyelitis (VEE) virus. Culex pseudes was highly susceptible to infection with both the IC and IE strains of VEE (infection rates >78%). Patterns of susceptibility to VEE were similar for Oc. taeniorhynchus collected in Mexico and Honduras. Although Oc. taeniorhynchus was highly susceptible to the epizootic IC strains (infection rates > or = 95%, n = 190), this species was less susceptible to the enzootic IE strain (infection rates < or = 35%, n = 233). The Culex (Culex) species were refractory to both subtypes of VEE, and none of 166 contained evidence of a disseminated infection. Virus-exposed Cx. pseudes that refed on susceptible hamsters readily transmitted virus, confirming that this species was an efficient vector of VEE. Although Oc. taeniorhynchus that fed on hamsters infected with the epizootic IC strain transmitted VEE efficiently, only one of six of those with a disseminated infection with the enzootic IE virus that fed on hamsters transmitted virus by bite. These data indicate that Cx. pseudes is an efficient laboratory vector of both epizootic and enzootic strains of VEE and that Oc. taeniorhynchus could be an important vector of epizootic subtypes of VEE.

  5. Analysis of sequences involved in IE2 transactivation of a baculovirus immediate-early gene promoter and identification of a new regulatory motif.

    Science.gov (United States)

    Shippam-Brett, C E; Willis, L G; Theilmann, D A

    2001-05-01

    Opep-2 is a unique baculovirus early gene that has only been identified in the Orgyia pseudotsugata multiple capsid nucleopolyhedrovirus (OpMNPV). Previous analyses have shown this gene is expressed at very early times post-infection (p.i.) but is shut down by 36-48 h p.i. The promoter of opep-2 therefore, represents a class of early genes that is temporally regulated. In this study, a detailed analysis of the opep-2 promoter is performed to analyze the role individual motifs play in early gene expression. A new 13 base pair regulatory element was identified and shown to be essential in controlling high-level expression of this gene. In addition, mutational analysis revealed that GATA and CACGTG motifs, which have been shown to bind cellular factors in Sf9 and Ld652Y cells, played minor roles in influencing opep-2 expression in the absence of other viral factors. The OpMNPV transactivator IE2 causes a significant activation of the opep-2 promoter. Cotransfection of an extensive number of promoter deletions and mutations did not show any sequence specificity for IE2 transactivation. This is the first detailed analysis of the sequence requirements for IE2 transactivation, and these results suggest that IE2 does not bind directly to specific elements in the opep-2 promoter.

  6. No effect of Bt Cry1Ie toxin on bacterial diversity in the midgut of the Chinese honey bees, Apis cerana cerana (Hymenoptera, Apidae)

    Science.gov (United States)

    Jia, Hui-Ru; Dai, Ping-Li; Geng, Li-Li; Jack, Cameron J.; Li, Yun-He; Wu, Yan-Yan; Diao, Qing-Yun; Ellis, James D.

    2017-01-01

    Cry1Ie protein derived from Bacillus thuringiensis (Bt) has been proposed as a promising candidate for the development of a new Bt-maize variety to control maize pests in China. We studied the response of the midgut bacterial community of Apis cerana cerana to Cry1Ie toxin under laboratory conditions. Newly emerged bees were fed one of the following treatments for 15 and 30 days: three concentrations of Cry1Ie toxin (20 ng/mL, 200 ng/mL, and 20 μg/mL) in sugar syrup, pure sugar syrup as a negative control and 48 ng/mL imidacloprid as a positive control. The relative abundance of 16S rRNA genes was measured by Quantitative Polymerase Chain Reaction and no apparent differences were found among treatments for any of these counts at any time point. Furthermore, the midgut bacterial structure and compositions were determined using high-throughput sequencing targeting the V3-V4 regions of the 16S rDNA. All core honey bee intestinal bacterial genera such as Lactobacillus, Bifidobacterium, Snodgrassella, and Gilliamella were detected, and no significant changes were found in the species diversity and richness for any bacterial taxa among treatments at different time points. These results suggest that Cry1Ie toxin may not affect gut bacterial communities of Chinese honey bees. PMID:28139751

  7. Criteria and test methodologies for injury assessment of vehicle occupants threatened by landmines and/or IED; an approach by HFM-148/RTG

    NARCIS (Netherlands)

    Horst, M.J. van der

    2010-01-01

    Today STANAG 4569 is working towards a new volume of the AEP-55 including the Improvised Explosive Devices (IED) threat to vehicles and their occupants. Therefore, a follow-up of the HFM-090/TG-25 was required to establish common NATO test procedures and injury criteria for both the Anti-Vehicular (

  8. La IED en España a finales del siglo XX. Análisis por países de origen

    Directory of Open Access Journals (Sweden)

    Miranda Torrado, Fernando

    2004-01-01

    Full Text Available La economía española no ha permanecido ajena al proceso de globalización de la economía mundial que ha tenido lugar en la última década del pasado siglo y en los albores del presente; y en el cual los flujos de inversión extranjera directa (IED han jugado un papel fundamental revelándose como los principales protagonistas del mismo. La teoría de la IED nos sugiere que son las empresas de los países más desarrollados y con una mayor renta per capita y un mayor tamaño -real o potencial- de mercado, las que disfrutan de unas condiciones más favorables para poder operar con éxito a nivel internacional. por tal motivo, entre otros,. cuanto más desarrollado es un país mayor es su tendencia ( o la de sus empresas a invertir en el exterior. Dado que la IED es la principal vía utilizada por las firmas para su expansión internacional cabría esperar que una gran proporción del total de los flujos internacionales de IED tengan su origen en los países desarrollados. A lo largo del presente trabajo se tratará de analizar el origen de los flujos de IED recibidos por nuestro país, describiendo cuales han sido las principales zonas y los principales países inversores en España durante el período 1993-2002 así como si la importancia relativa de unas y otros se ha mantenido o no durante el periodo considerado

  9. Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants.

    Science.gov (United States)

    Gibson, Laura; Dooley, Sheryl; Trzmielina, Sonia; Somasundaran, Mohan; Fisher, Donna; Revello, Maria Grazia; Luzuriaga, Katherine

    2007-06-15

    Cytomegalovirus (CMV) infection remains a significant cause of morbidity and mortality in young children. We have previously shown that CD8+ T cell responses to CMV pp65 or IE1 protein were readily detectable in children with congenital or postnatal CMV infection. Here, we have further characterized the evolution of the peptide specificity of these responses in 7 infants<6 months of age at the start of the study. Thirteen pp65 and 15 IE1 peptides (median, 5 peptides/infant) were targeted, and most (61%) represented sequences not previously reported. Peptide specificity remained stable or broadened over time despite the clearance of CMV viremia. Loss of peptide recognition was not observed. Responses with the highest functional peptide avidity were not necessarily detected earliest. These data provide additional evidence that young infants can generate diverse CMV-specific CD8+ T cell responses but show that early responses may exhibit relatively focused peptide specificity and lower peptide avidity.

  10. Avaliação do Beyond Budgeting Como Ferramenta de Planejamento e Controle na Visão dos Gestores de IES

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Facin Lavarda

    2011-11-01

    Full Text Available The need of best management practices reaches all the companies that come across for continuity and the studies that look for to supply new instruments to the management they appear as the knowledge moves forward, among them, Beyond Budgeting was presented as substitute to the traditional budget. The present study, of exploratory character, looked for to identify the IES managers’ view located in the Brazil South area with relationship to the budget use. Through structured questionnaires, it was looked for to know if the critics done to the model of traditional budget they are applied in IES as well as if the benefits indicated by new approaches defenders are applied to these institutions. As main result, we identified traditional budget critics are not applied at studied entities, and the option for Beyond Budgeting would not bring changes for the institutions, because a great part of benefits proposed by the new tool is already applied in the institutions.

  11. [Nourseothricin (streptothricin) inactivated by plasmid pIE 636-encoded acetyltransferase: detection of N-acetyl-beta-lysine in the inactivated product].

    Science.gov (United States)

    Seltmann, G

    1985-12-01

    Nourseothricin (streptothricin) can be inactivated by an acetyl transferase synthesized by E. coli strains containing plasmid pIE 636. Nourseothricin inactivated in the presence of 14C-acetyl-coenzyme A was purified and submitted to partial acidic hydrolysis. By electrophoresis of the hydrolysate a 14C-containing substance moving only slowly towards the cathode could be isolated. This substance after complete hydrolysis yields only unlabelled beta-lysine.

  12. Hydraulic demand characteristics of self-supported C-IV-N and K-I-N I&E fuel elements in a zirconium C-Reactor tube

    Energy Technology Data Exchange (ETDEWEB)

    Waters, E.D.

    1960-01-13

    This report discusses the isothermal hydraulic demand characteristics were determined by laboratory experiment for full charges of self-supported I&E fuel elements in a zirconium process tube. Pressure drop, flow rate data, and the calculations of annulus-to-hole flow ratio are presented. For self-supported fuel elements, pressure drop does not vary with temperature as much as it dies for non-self-supported furl elements.

  13. A randomised clinical trial of comprehensive cardiac rehabilitation versus usual care for patients treated for infective endocarditis—the CopenHeartIE trial protocol

    Science.gov (United States)

    Rasmussen, Trine Bernholdt; Zwisler, Ann-Dorthe; Sibilitz, Kirstine Lærum; Risom, Signe Stelling; Bundgaard, Henning; Gluud, Christian; Moons, Philip; Winkel, Per; Thygesen, Lau Caspar; Hansen, Jane Lindschou; Norekvål, Tone Merete; Berg, Selina Kikkenborg

    2012-01-01

    Introduction Infective endocarditis (IE) is among the most serious infectious diseases in the western world. Treatment requires lengthy hospitalisation, high-dosage antibiotic therapy and possible valve replacement surgery. Despite advances in treatment, the 1-year mortality remains at 20–40%. Studies indicate that patients experience persisting physical symptoms, diminished quality of life and difficulties returning to work up to a year postdischarge. No studies investigating the effects of rehabilitation have been published. We present the rationale and design of the CopenHeartIE trial, which investigates the effect of comprehensive cardiac rehabilitation versus usual care for patients treated for IE. Methods and analysis We will conduct a randomised clinical trial to investigate the effects of comprehensive cardiac rehabilitation versus usual care on the physical and psychosocial functioning of patients treated for IE. The trial is a multicentre, parallel design trial with 1 : 1 individual randomisation to either the intervention or control group. The intervention consists of five psychoeducational consultations provided by specialised nurses and a 12-week exercise training programme. The primary outcome is mental health (MH) measured by the standardised Short Form 36 (SF-36). The secondary outcome is peak oxygen uptake measured by the bicycle ergospirometry test. Furthermore, a number of exploratory analyses will be performed. Based on sample size calculation, 150 patients treated for left-sided (native or prosthetic valve) or cardiac device endocarditis will be included in the trial. A qualitative and a survey-based complementary study will be undertaken, to investigate postdischarge experiences of the patients. A qualitative postintervention study will explore rehabilitation participation experiences. Ethics and dissemination The study complies with the Declaration of Helsinki and was approved by the regional research ethics committee (no H-1

  14. Uranium from German nuclear projects of the 1940ies. A nuclear forensic study; Uran aus deutschen Nuklearprojekten der 1940er Jahre. Eine nuklearforensische Untersuchung

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, Klaus; Wallenius, Maria; Luetzenkirchen, Klaus [European Comission, Joint Research Centre (JRC), Karlsruhe (Germany). Inst. for Transuranium Elements (ITU); and others

    2015-11-02

    In the 1940ies in Germany studies using uranium in different geometries were started. Using the isotope ration Th-230/U-234 it was possible to determine the materials used in 1949-1943.The geographic origin was determined from trace amounts of rare earths. The uranium used in German research projects came from Czech uranium mines. Traces of U-236 and Pu-236 were found corresponding to the normal occurrence. This fact indicates that no significant neutron irradiation has occurred.

  15. Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition.

    Directory of Open Access Journals (Sweden)

    Edze R Westra

    Full Text Available Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat, into which invader DNA fragments are incorporated. CRISPR transcripts are processed into small RNAs that guide CRISPR-associated (Cas proteins to invading nucleic acids by complementary base pairing. However, to avoid autoimmunity it is essential that these RNA-guides exclusively target invading DNA and not complementary DNA sequences (i.e., self-sequences located in the host's own CRISPR locus. Previous work on the Type III-A CRISPR system from Staphylococcus epidermidis has demonstrated that a portion of the CRISPR RNA-guide sequence is involved in self versus non-self discrimination. This self-avoidance mechanism relies on sensing base pairing between the RNA-guide and sequences flanking the target DNA. To determine if the RNA-guide participates in self versus non-self discrimination in the Type I-E system from Escherichia coli we altered base pairing potential between the RNA-guide and the flanks of DNA targets. Here we demonstrate that Type I-E systems discriminate self from non-self through a base pairing-independent mechanism that strictly relies on the recognition of four unchangeable PAM sequences. In addition, this work reveals that the first base pair between the guide RNA and the PAM nucleotide immediately flanking the target sequence can be disrupted without affecting the interference phenotype. Remarkably, this indicates that base pairing at this position is not involved in foreign DNA recognition. Results in this paper reveal that the Type I-E mechanism of avoiding self sequences and preventing autoimmunity is fundamentally different from that employed by Type III-A systems. We propose the exclusive targeting of PAM-flanked sequences to be termed a target versus non-target discrimination mechanism.

  16. Equine herpesvirus 1 gene 12, the functional homologue of herpes simplex virus VP16, transactivates via octamer sequences in the equine herpesvirus IE gene promoter.

    Science.gov (United States)

    Elliott, G; O'Hare, P

    1995-10-20

    The HSV-1 transactivator of immediate-early (IE) gene expression, VP16, has several functional homologues among the alphaherpesviruses which have not yet been extensively studied in relation to their modes of action. To date, nothing is known of the exact sites or mechanism of interaction of the equine herpesvirus type 1 (EHV-1) homologue, the gene 12 protein, with the EHV-1 IE promoter. We show that the gene 12 protein utilises the promoter proximal region of the IE gene to induce activation and identify four potential octamer DNA binding sites within that region. Although there was divergence from its consensus, Oct-1 bound to each of these sites in an in vitro complex formation assay, and in the presence of the gene 12 product a second complex of slower migration, which was also dependent on Oct-1, was detected. When each site was inserted into a basal promoter, two conferred activation by gene 12 with a resulting increase in expression of up to 50-fold compared to basal levels. These results show that, despite the differences between the two proteins, the mechanism of interaction of the gene 12 protein with its target is analogous to that of VP16.

  17. ASPECTE PRIVIND RECUNOAŞTEREA, EVALUAREA ŞI CONTABILIZAREA PRODUSELOR ŞI A PRODUCŢIEI ÎN CURS DE EXECUŢIE

    Directory of Open Access Journals (Sweden)

    Galina BĂDICU

    2015-12-01

    Full Text Available Obiectul prezentei investigaţii este de a elucida regulilie prevăzute de reglementările contabile naţionale cu privire la contabilitatea produselor şi a producţiei în curs de execuţie, în scopul eficientizării aplicării acestora în practica entită-ţilor de producţie. În acest context, autorul îşi propune investigarea problematicilor actuale aferente contabilităţii aces-tora, precum: recunoaşterea, evaluarea în cazul diverselor procedee, repartizarea costurilor în cazul obţinerii produselor finite şi a producţiei în curs de excecuţie, a produselor cuplate sau a unui produs principal şi altui secundar.ASPECTS REGARDING THE RECOGNITION, EVALUOTION AND ACCOUNTING OF PRODUCTS AND PRODUCTION IN PROGRESSThe aim of our research is to elucidate the rules stipulated national accounting standards relating to products and production in progress accounting, in order to improve their usage in production entities practice. In this context, the author recommends an investigation of current issues related to their accounting, such as: recognition, evaluation in different processes, costs allocation in case of finished and work in progress products acquisition, coupled products acquisition or a main and other secondary product acquisition.

  18. Mecanismos para incrementar las competencias de investigación e innovación en las IES de la FIMPES

    Directory of Open Access Journals (Sweden)

    Mario Sánchez de los Monteros Montoya

    2013-01-01

    Full Text Available Antes de proponer mecanismos conviene revisar cómo hace investigación la IES particular. La Misión no expresa a la investigación como un producto principal y visible de la función educativa. La sociedad no tiene la manera de demandar ni de medir los impactos reales de la actividad educativa. La Visión tampoco prioriza a la investigación como meta, y ni la menciona en su declaratoria de calidad. Ello es contradictorio y deja ver que la IES particular no está preparada para competir a la par de las necesidades de la sociedad del conocimiento. Por ende, hay vacíos en el conocimiento y se deja a la calidad un papel que no agrega valor. Finalmente, el ensayo propone mecanismos advirtiendo previamente a las IES particulares los cimientes requerid os para hacer de la investigación una actividad productiva.

  19. Raman detection of improvised explosive device (IED) material fabricated using drop-on-demand inkjet technology on several real world surfaces

    Science.gov (United States)

    Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.

    2015-05-01

    The requirement to detect hazardous materials (i.e., chemical, biological, and explosive) on a host of materials has led to the development of hazard detection systems. These new technologies and their capabilities could have immediate uses for the US military, national security agencies, and environmental response teams in efforts to keep people secure and safe. In particular, due to the increasing use by terrorists, the detection of common explosives and improvised explosive device (IED) materials have motivated research efforts toward detecting trace (i.e., particle level) quantities on multiple commonly encountered surfaces (e.g., textiles, metals, plastics, natural products, and even people). Non-destructive detection techniques can detect trace quantities of explosive materials; however, it can be challenging in the presence of a complex chemical background. One spectroscopic technique gaining increased attention for detection is Raman. One popular explosive precursor material is ammonium nitrate (AN). The material AN has many agricultural applications, however it can also be used in the fabrication of IEDs or homemade explosives (HMEs). In this paper, known amounts of AN will be deposited using an inkjet printer into several different common material surfaces (e.g., wood, human hair, textiles, metals, plastics). The materials are characterized with microscope images and by collecting Raman spectral data. In this report the detection and identification of AN will be demonstrated.

  20. White spot syndrome virus IE1 and WSV056 modulate the G1/S transition by binding to the host retinoblastoma protein.

    Science.gov (United States)

    Ran, Xiaozhuo; Bian, Xiaofang; Ji, Yongchang; Yan, Xiumin; Yang, Feng; Li, Fang

    2013-12-01

    DNA viruses often target cellular proteins to modulate host cell cycles and facilitate viral genome replication. However, whether proliferation of white spot syndrome virus (WSSV) requires regulation of the host cell cycle remains unclear. In the present study, we show that two WSSV paralogs, IE1 and WSV056, can interact with Litopenaeus vannamei retinoblastoma (Rb)-like protein (lv-RBL) through the conserved LxCxE motif. Further investigation revealed that IE1 and WSV056 could also bind to Drosophila retinoblastoma family protein 1 (RBF1) in a manner similar to how they bind to lv-RBL. Using the Drosophila RBF-E2F pathway as a model system, we demonstrated that both IE1 and WSV056 could sequester RBF1 from Drosophila E2F transcription factor 1 (E2F1) and subsequently activate E2F1 to stimulate the G1/S transition. Our findings provide the first evidence that WSSV may regulate cell cycle progression by targeting the Rb-E2F pathway.

  1. Study of aac(6'Ie-aph(2″Ia Gene in Clinical Strain of Enterococci and Identification of High-Level Gentamicin Resistante Enterococci

    Directory of Open Access Journals (Sweden)

    N. Dadfarma

    2010-10-01

    Full Text Available Introduction & Objective: Enterococci have emerged as the leading nosocomial pathogens. In addition to natural resistance to many agents, enterococci have also developed plasmid- and transposon-mediated resistance to high concentrations of aminoglycosides. High-level gentamicin resistance (HLGR of enterococci results in the failure of drug synergism with an aminoglycoside plus cell-wall-active agents. HLGR (MIC=500μg/ml strains is usually due to the presence of the aac(6'Ie-aph(2″Ia gene . Materials & Methods: In the present experimental study 142 enterococci were isolated from the patients’ species. Identification was done by using standard methods and antimicrobial susceptibility test was performed by disc diffusion technique. MIC of Gentamicin was determined by a broth micro dilution method (NCCLS. PCR was performed to detect the aac(6'Ie-aph(2″Ia gene .Presence of the gene aac(6'-Ie-aph(2″-Ia was confirmed by digest with Sca1 enzyme. A PCR product was sequenced and BLAST analyzed at the NCBI database to be confirmed. Results: 62(43.7% out of the 142 isolates, were found to exhibit HLGR phenotype. MIC ranging from 512 to >1024 μg/ml in 55 HLGR isolates. All resistant isolates except one, were found to harbor the aac(6'Ie-aph(2″Ia gene. In our strain collection, 42% of E. faecalis and 44% of E. faecium were HLGR. In the HLGR isolates the prevalence of resistance to other antibiotics and Multi Drug Resistance (MDR was higher than non–HLGR.This prevalence in E.faecium was higher than E.faecalis. The sequence was compared with a published sequence and confirmed. Conclusion: Our results indicate that high prevalence of MDR and HLGR enterococcal colonization is an important problem in our medical centers.Spread of the aac(6'-Ie-aph(2″-Ia gene was responsible for HLGR among enterococci isolated from the patients in Tehran. (Sci J Hamadan Univ Med Sci 2010;17(3:25-32

  2. Performance Analysis of Industrial Network CC-LINK IE%工业以太网CC-LINK IE的性能分析

    Institute of Scientific and Technical Information of China (English)

    周丽娟

    2013-01-01

    The industrial Ethernet CC-LINK IE, based on Gigabit Ethernet, has released two major products control network and field network, providing seamless communication between upper-level information systems and lower-level field systems.CC-LINK IE makes not much difference in data capacity and transmission speed with Gigabit Ethernet, and breaks through the problem of time delay which exists in traditional industrial networks. In addition, its wiring design allows double ring topology to ensure the network can work normally even if one station in the loop happens to malfunction, largely improves the reliability. This text will analyze the advantages and disadvantages of CC-LINK IE and other industrial networks. Finally the interrelated application case is recited.%  基于以太网的整合网络CC-LINK IE系列推出的控制网络与现场网络,实现了从上位信息系统到下位现场系统的无缝协作.CC-LINK IE在数据容量与传输速度方面都与商用以太网相差无几,又很大程度上突破了传统工业以太网的延时性.除此之外,CC-LINK IE采用双环路的网络结构,任何一个站出现故障都不会干扰整个网络的数据交换,很大程度上提高了可靠性.本文比较了CC-LINK IE与其他工业以太网的优缺点,最后提出有关应用案例.

  3. Plan de acción de interconexión de fuentes de información con SNIES local en una IES

    OpenAIRE

    2011-01-01

    En el proyecto se analiza la estructura de la base de datos creada por el Ministerio de Educación Nacional, “MEN” para soportar el Sistema Nacional de Información de la Educación Superior, “SNIES” en el que se consolida la información de las IES a nivel nacional y es de estricto cumplimiento y para el cual se ha establecido una serie de requerimientos a cumplir en el registro de información con miras a su posterior carga a través de un aplicativo web en la citada base de datos que se encuentr...

  4. Estrategia de ahorro energético del IES Bellulla a través de Revit y DesignBuilder

    OpenAIRE

    Medina Caballero, Wilson Jaime

    2015-01-01

    El siguiente Proyecto Final de Grado trata sobre la realización de una Auditoria Energética del IES Bellulla, el cual es un centro docente de la población de Canovelles, que imparte Educación Secundaria Obligatoria (ESO) y Bachillerato. Dicha escuela contiene dos zonas diferenciadas por su uso de manera genérica, aunque en las dos se imparten clases, a la primera se le llamará “Zona de Aulas” y a la otra “Zona del Pabellón” (Tal como se aprecia en la imagen 2.1.1.3). Decidí ...

  5. About IE application in heavy truck manufacturing industry%关于IE在重卡制造业中的应用

    Institute of Scientific and Technical Information of China (English)

    孔姗姗

    2015-01-01

    介绍了某重卡调整线运用IE手法,引入工业工程中的作业分析、程序分析、作业分析、动作分析等方法和思想,对生产线进行改善。%This paper introduces a heavy truck line using IE technique analysis, the introduction of industrial engineering work process analysis, operation analysis, operation analysis and other methods and ideas to improve production line.

  6. ANTREPRENORIATUL SOCIAL ESTE O SOLUȚIE PE TERMEN LUNG. INTERVIU CU DOAMNA MONA NICOLICI, MANAGER RELAȚII COMUNITARE ÎN CADRUL PETROM

    Directory of Open Access Journals (Sweden)

    Dorian Ilie

    2013-05-01

    Full Text Available Acest interviu a fost realizat cu doamna Mona Nicolici, Manager Relații Comunitare în cadrul Petrom. Am discutat cu doamna Nicolici despre competiția de afaceri sociale Fabricat în Țara lui Andrei, concurs lansat la începutul acestui an, despre proiectul Țara lui Andrei din care face parte această competiție, despre programul de responsabilitate socială corporatistă al Petrom și despre planurile de viitor ale companiei din acest punct de vedere.

  7. MANIPULAREA UNUI EVENIMENT ȘI PARIURILE ARANJATE (art.2421 ȘI 2422 CP RM: INFRACȚIUNI DE CORUPȚIE?

    Directory of Open Access Journals (Sweden)

    Gheorghe RENIŢĂ

    2017-07-01

    Full Text Available În prezentul demers științific ne propunem să oferim răspuns la întrebarea cu care el se deschide: manipularea unui eveniment și pariurile aranjate (art.2421 și 2422 din Codul penal al Republicii Moldova (CP RM: infracțiuni de corupție? Altfel spus, este oare îndreptățită optica de a raporta infracțiunile de manipulare a unui eveniment și de pariuri aranjate la grupul celor de corupție? Punctul de pornire pentru elaborarea acestei investigații l-a constituit Proiectul de Lege nr.268/2016, care, inter alia, urmărește includerea art.2421 și 2422 CP RM printre infracțiunile de corupție. În acest sens, se constată că fapta exprimată în încurajarea, influenţarea sau instruirea unui participant la un eveniment sportiv sau la un eveniment de pariat să întreprindă acţiuni care ar produce un efect viciat asupra evenimentului respectiv, cu scopul de a obţine bunuri, servicii, privilegii sau avantaje sub orice formă, care nu i se cuvin, pentru sine sau pentru o altă persoană (art.2421 CP RM, precum și fapta de pariere pe un eveniment sportiv sau pe un alt eveniment de pariat, fie în informarea altor persoane despre existenţa unei înţelegeri în privinţa trucării acelui eveniment în intenţia de a le determina să participe la pariul respectiv, săvârşită de către o persoană care cunoaşte cu certitudine despre existenţa unei înţelegeri privind trucarea acelui eveniment (art.2422 CP RM, nu au cum să se plieze normelor care instituie răspunderea penală pentru coruperea pasivă (art.324 CP RM, coruperea activă (art.335 CP RM, traficul de influență (art.326 CP RM, luarea de mită (art.333 CP RM sau darea de mită (art.334 CP RM. Or, aceste prevederi incriminatoare au raze diferite de acțiune. Se relevă că pentru a atribui o infracțiune sau alta la categoria celor de corupție este ineluctabil ca aceasta să corespundă trăsăturilor definitorii ale corupției, și anume: să afecteze exercitarea

  8. Atuação do departamento de marketing em uma instituição de ensino superior – IES

    Directory of Open Access Journals (Sweden)

    José Vorlei Guimarães Martins

    2011-05-01

    Full Text Available O mercado educacional vive momentos de intensas transformações, principalmente em razão da grande concorrência do setor. O presente artigo tem por objetivo fazer uma análise geral desse mercado, evidenciando a ótica do marketing, sua importância e a necessidade de adaptação à nova economia e suas exigências. Para tal, utilizamos a metodologia da pesquisa bibliográfica e documental. Os resultados apontam para a necessidade de ações estratégicas de marketing, visando ao fortalecimento das Instituições de Ensino Superior – IES na acirrada concorrência existente no setor. Percebemos que, até a bem pouco tempo, grande parte das IES focava seus investimentos em prédios e laboratórios, sem a devida preocupação de identificar as expectativas e desejos dos alunos e as exigências do mercado. Concluímos que a nova realidade exige, hoje, um posicionamento transparente e que a reputação da marca e os valores a ela agregados ganham cada vez mais importância, o que implica no desenvolvimento de ações internas e externas, dentro de uma óptica que classifica o aluno como cliente, não apenas como estudante.

  9. DEFINIŢIA LEGISLATIVĂ A NOŢIUNII „PERSOANĂ CU FUNCŢIE DE DEMNITATE PUBLICĂ”: ANALIZA EVOLUŢIEI

    Directory of Open Access Journals (Sweden)

    Sergiu BRÎNZA

    2017-01-01

    Full Text Available Scopul investigaţiei de faţă rezidă în analiza evoluţiei pe care a parcurs-o definiţia legislativă a noţiunii „persoană cu funcţie de răspundere”. Se relevă că dispoziţia de la alin.(3 art.123 CP RM a fost supusă unor amendamente prin Legea nr.318/2013 şi prin Legea nr.152/2016. Se stabileşte că în rezultatul acestor amendamente: din respectiva dispoziţie a fost exclus textul „consilierul local; deputatul în Adunarea Populară a Găgăuziei;”; în dispoziţia alin.(3 art.123 CP RM, cu­vin­tele „în condiţiile legii” au fost substituite cu cuvintele „altă persoană cu funcţie de demnitate publică stabilită prin lege”. Se demonstrează că consilierul local şi deputatul în Adunarea Populară a Găgăuziei nu sunt persoane cu funcţii de demnitate publică nici în sensul Legii nr.199/2010, nici în sensul alin.(3 art.123 CP RM. Se ajunge la concluzia că, în rezultatul adoptării Legii nr.152/2016, definiţia noţiunii „persoană cu funcţie de demnitate publică” s-a transformat din definiţie exhaustivă în definiţie exemplificativă. Se argumentează că sintagma „altă persoană cu funcţie de demnitate publică stabilită prin lege” din alin.(3 art.123 CP RM arată că această normă constituie o normă divizată de referire. Se explică de ce este falsă impresia că ar exista persoane cu funcţie de demnitate publică, care nu sunt specificate în anexa la Legeanr.199/2010 şi cărora nu li se aplică prevederile acestei legi. Se conchide că alin.(3 art.123 CP RM, complinit de anexa la Legeanr.199/2010, sunt singurele norme care stabilesc conţinutul noţiunii „persoană cu funcţie de demnitate publică”. Alte norme pot doar să dezvolte prevederile acestora, fără a le lărgi sfera de incidenţă. Printre astfel de norme dezvoltătoare se numără: alin.(3 art.17 din Codul electoral; alin.(51 art.42 al Legii cu privire la energetică; art.131 al Legii privind Comisia Na

  10. A educação superior e a perspectiva agroecológica: avanços e limites dos Núcleos de Agroecologia das IES no Brasil

    Directory of Open Access Journals (Sweden)

    Luis Mauro Santos Silva

    2017-04-01

    Full Text Available O presente artigo trás reflexões sobre a importância dos Núcleos de Estudos Agroecológicos (NEAs criados via políticas do Governo Federal. No contexto analisado, os NEAs se apoiam, invariavelmente, nas lógicas familiares de produção como protagonistas de um novo formato de ensino, pesquisa e extensão. Baseado em uma revisão documental e teórica, observou-se que a proposta de criação dos núcleos trás como inovação, princípios para a construção coletiva de conhecimentos agroecológicos, ou seja, socialmente elaborados e considerando as múltiplas dimensões do desenvolvimento regional. Para a criação desses NEAS em todo o território nacional, fez-se necessário o envolvimento ativo dos mais diversos atores sociais e as IES, possibilitando uma nova perspectiva epistemológica, onde o saber popular ganha em reconhecimento e contribui na busca de resoluções de demandas sociais locais, sejam elas produtivas, educacionais, ecológicas, tecnológicas etc. Vale salientar que por meio desses ambientes coletivos, novos cenários Institucionais surgiram. A própria criação de novas IES, especialmente nas regiões mais distantes dos grandes centros urbanos, mostrou uma maior sensibilidade na incorporação de demandas locais da sociedade civil. E, mesmo com limites bem marcados dessa iniciativa pública, em menos de uma década essa ação vem proporcionando uma efetiva articulação regional e nacional de novos formatos de IES, tornando os NEAs referências no debate em torno de temas estratégicos ligados a perspectiva agroecológica.

  11. Mudança organizacional, aprendizagem e estresse: um estudo de caso numa IES Organizational change, learning and stress: a case study in university education

    Directory of Open Access Journals (Sweden)

    Daniele Cristine Nickel

    2007-09-01

    Full Text Available O presente trabalho procura identificar as relações entre a mudança organizacional do sistema seriado para o modular, a percepção de estresse e as atitudes de aprendizagem de docentes em uma IES que oferece cursos de Administração, Economia e Ciências Contábeis (extensão, aperfeiçoamento, especialização, mestrado, doutorado e MBAs. Os elementos de análise deste trabalho referem-se a Mudança, Aprendizagem Organizacional e Estresse. A IES pesquisada atua em Curitiba há mais de 40 anos. O processo de mudança é caracterizado a partir de fatores que são percebidos como fontes de pressão pelos professores que atuam no novo sistema, buscando-se identificar a relação desses fatores com o desencadeamento do estresse e as atitudes de aprendizagem individual e organizacional apresentadas. Para o estudo de caso foram aplicadas entrevistas semi-estruturadas e dois questionários, um aberto e outro fechado. Para análise dos dados foram utilizados os métodos quantitativo e qualitativo. Conclui-se que a aprendizagem é tanto essencial para a assimilação do processo de mudança organizacional como geradora de estresse.Relations between the organizational change from a serial to modular system and perception of stress and learning attitudes were identified in professors of an IES in Curitiba that has taught Administration, Economy and Accounting Sciences (extension, development, specialization, master, doctorate and MBA degrees for 40 years. The elements of analysis in the study were associated with change, organizational learning and stress. The change process was characterized by factors such as pressure related to the new system, emergence of stress, learning attitudes, and the relation between learning and stress. Case study, open-ended interviews and two questionnaires were used. Quantitative and qualitative methods were used for data analysis. It was concluded that learning is essential to assimilate the organizational change

  12. Reliability, sensitivity and validity of the assistant referee intermittent endurance test (ARIET) - a modified Yo-Yo IE2 test for elite soccer assistant referees

    DEFF Research Database (Denmark)

    Castagna, Carlo; Bendiksen, Mads; Impellizzeri, Franco M

    2012-01-01

    We examined the reliability and validity of the assistant referee intermittent endurance test (ARIET), a modified Yo-Yo IE2 test including shuttles of sideways running. The ARIET was carried out on 198 Italian (Serie A-B, Lega-Pro and National Level) and 47 Danish elite soccer assistant referees....... Reproducibility was tested for 41 assistant referees on four occasions each separated by one week. The ARIET intraclass correlation coefficients and typical error of measurement ranged from 0.96 to 0.99 and 3.1 to 5.7%, respectively. ARIET performance for Serie A and B was 23 and 25% greater than in Lega-Pro (P...... = 0.95, P assistant referees of different competitive levels. The lack of correlation with sprinting ability and close correlations...

  13. Diagnóstico del servicio de alimentación escolar en el comedor escolar del Colegio Saludcoop Sur I.E.D

    OpenAIRE

    Arce Jaramillo, Fania

    2016-01-01

    El presente documento es el informe del trabajo desarrollado en la práctica institucional que se realizó en el Comedor Escolar del Colegio Saludcoop Sur I.E.D de la localidad de Kennedy en la ciudad de Bogotá, durante el segundo semestre del año 2015. Consistió en el diagnóstico del Proyecto de Alimentación Escolar de la Secretaría de Educación de Bogotá desde el caso del Comedor Escolar del colegio Saludcoop Sur, a la luz de los criterios de la atención diferencial. Se implementó una metodol...

  14. DILEMA DIFERENŢIERII RĂSPUNDERII PENALE PENTRU RELELE TRATAMENTE COMISE DE O PERSOANĂ CU FUNCŢIE DE RĂSPUNDERE

    Directory of Open Access Journals (Sweden)

    Daniela URSU

    2017-01-01

    Full Text Available Deoarece unele autorităţi (ca, de exemplu, poliţistul sunt, potrivit literei legii (art.123 alin.(1 şi alin.(2 CP RM, atât persoane publice, cât şi persoane cu funcţie de răspundere, în contextul relelor tratamente incriminate la art.1661 CP RM, unii subiecţi de aplicare în concret a legii penale recunosc poliţistului calitatea de persoană cu funcţie de răspundere, motiv din care reţin circumstanţa agravantă în dependenţă de faptă, prevăzută fie la lit.e alin.(2, fie la lit.e alin.(4 art.1661 CP RM, iar alţii îi reţin calitatea de persoană publică, încadrându-i faptele în acord cu variantele-tip ale infrac­ţiu­nilor de tortură, tratament inuman sau degradant. Pornind de la câteva hotărâri din practica judiciară naţională, pre­zentul studiu îşi propune să ofere răspuns la următoarea întrebare: Care este cea mai potrivită soluţie de calificare în ipo­teza comiterii infracţiunilor de tortură, tratament inuman sau degradant de către autorităţi care deţin dubla calitate: atât de persoană publică, cât şi de persoană cu funcţie de răspundere?THE DIFFERENTIATION DILEMMA OF CRIMINAL LIABILITY REGARDING THE ILL-TREATMENT COMMITTED BY A PERSON WITH PUBLIC RESPONSIBILITIESBecause some authorities, like the policeman, are according to the law (Article 123 para.(1 and para.(2 of the Penal Code of Moldova, both public persons and persons holding responsible positions, in the context of maltreatment incri­minated by the article 1661 of the Penal Code of Moldova, some subjects invested with the power to apply the criminal law treat the police officials as persons holding a responsible positions, the reason why the aggravating circumstance, depending on the offense, is either letter e para.(2, either – letter e para.(4 article 1661 of the Penal Code of Moldova. While others treat them as public persons, stating their crimes as torture, inhuman or degrading treatment. Starting from several

  15. Reliability, sensitivity and validity of the assistant referee intermittent endurance test (ARIET) - a modified Yo-Yo IE2 test for elite soccer assistant referees.

    Science.gov (United States)

    Castagna, Carlo; Bendiksen, Mads; Impellizzeri, Franco M; Krustrup, Peter

    2012-01-01

    We examined the reliability and validity of the assistant referee intermittent endurance test (ARIET), a modified Yo-Yo IE2 test including shuttles of sideways running. The ARIET was carried out on 198 Italian (Serie A-B, Lega-Pro and National Level) and 47 Danish elite soccer assistant referees. Reproducibility was tested for 41 assistant referees on four occasions each separated by one week. The ARIET intraclass correlation coefficients and typical error of measurement ranged from 0.96 to 0.99 and 3.1 to 5.7%, respectively. ARIET performance for Serie A and B was 23 and 25% greater than in Lega-Pro (P referees of different competitive levels. The lack of correlation with sprinting ability and close correlations with aerobic power, intermittent shuttle running and sub-maximal ARIET heart rate loading provide evidence that ARIET is a relevant test for assessment of intermittent endurance capacity of soccer assistant referees.

  16. Análise do perfil dos estudantes de uma IES: o marketing como ferramenta para as instrituições de ensino superior

    Directory of Open Access Journals (Sweden)

    Palloma Rodrigues de Andrade

    2011-01-01

    Full Text Available As instituições de ensino superior (IES privadas enfrentam uma crise derivada, em grande parte, da estabilização da demanda e pela queda de receitas, que representam desafios relacionados à gestão. O marketing procura dar respostas a alguns aspectos importantes das empresas, ao combinar as necessidades do consumidor com as capacidades e metas da empresa. Uma das abordagens para o mercado educacional consiste no marketing de alvo, no qual se divide o mercado em diferentes segmentos, e desenvolvem-se ofertas específicas de atendimento. A presente pesquisa surgiu do interesse em se conhecer melhor o comportamento dos indivíduos na escolha por serviços em educação, realizando-se uma segmentação psicográfica. Foi realizado um estudo de caso em uma IES privada, no qual se procurou conhecer sua clientela. Participaram 208 estudantes de diferentes cursos, selecionados por meio de amostragem por conveniência. Estes responderam a um instrumento composto pelos questionários de personalidade, valores humanos básicos e necessidade por cognição. Observou-se que os valores humanos e os fatores de personalidade são variáveis adequadas para se segmentar este público, enquanto a necessidade por cognição não possui capacidade discriminativa entre os estudantes dos diferentes cursos. Espera-se que estes resultados contribuam para o desenvolvimento de ações específicas de marketing educacional.

  17. Concurrent IMRT and weekly cisplatin followed by GDP chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell lymphoma.

    Science.gov (United States)

    Ke, Q-H; Zhou, S-Q; Du, W; Liang, G; Lei, Y; Luo, F

    2014-12-12

    On the basis of the benefits of frontline radiation in early-stage, extranodal natural killer (NK)/T-cell lymphoma (ENKTL), we conducted the trial of concurrent chemoradiotherapy (CCRT) followed by three cycles of gemcitabine, dexamethasone and cisplatin (GDP). Thirty-two patients with newly diagnosed, stage IE to IIE, nasal ENKTL received CCRT (that is, all patients received intensity-modulated radiotherapy 56 Gy and cisplatin 30 mg/m(2) weekly, 3-5 weeks). Three cycles of GDP (gemcitabine 1000 mg/m(2) intravenously (i.v.) on days 1 and 8, dexamethasone 40 mg orally on days 1-4 and cisplatin 75 mg/m(2) i.v. on day 1 (GDP), every 21 days as an outpatient were scheduled after CCRT. All patients completed CCRT, which resulted in 100% response that included 24 complete responses (CRs) and eight partial responses. The CR rate after CCRT was 75.0% (that is, 24 of 32 responses). Twenty-eight of the 32 patients completed the planned three cycles of GDP, whereas four patients did not because they withdrew (n = 1) or because they had an infection (n = 3). The overall response rate and the CR rate were 90.6% (that is, 29 of 32 responses) and 84.4% (that is, 27 of 32 responses), respectively. Only two patient experienced grade 3 toxicity during CCRT (nausea), whereas 13 of the 30 patients experienced grade 4 neutropenia. The estimated 3-year overall survival and progression-free rates were 87.50% and 84.38%, respectively. In conclusion, CCRT followed by GDP chemotherapy can be a feasible and effective treatment strategy for stage IE to IIE nasal ENKTL.

  18. Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS

    Directory of Open Access Journals (Sweden)

    Lorna A Renner

    2013-09-01

    Full Text Available Introduction: There is a risk of anaemia among HIV-infected children on antiretroviral therapy (ART containing zidovudine (ZDV recommended in first-line regimens in the WHO guidelines. We estimated the risk of severe anaemia after initiation of a ZDV-containing regimen in HIV-infected children included in the IeDEA West African database. Methods: Standardized collection of data from HIV-infected children (positive PCR<18 months or positive serology ≥18 months followed up in HIV programmes was included in the regional IeDEA West Africa collaboration. Ten clinical centres from seven countries contributed (Benin, Burkina Faso, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal to this collection. Inclusion criteria were age <16 years and starting ART. We explored the data quality of haemoglobin documentation over time and the incidence and predictors of severe anaemia (Hb<7g/dL per 100 child-years of follow-up over the duration of first-line antiretroviral therapy. Results: As of December 2009, among the 2933 children included in the collaboration, 45% were girls, median age was five years; median CD4 cell percentage was 13%; median weight-for-age z-score was−2.7; and 1772 (60.4% had a first-line ZDV-containing regimen. At baseline, 70% of the children with a first-line ZDV-containing regimen had a haemoglobin measure available versus 76% in those not on ZDV (p≤0.01: the prevalence of severe anaemia was 3.0% (n=38 in the ZDV group versus 10.2% (n=89 in those without (p<0. 01. Over the first-line follow-up, 58.9% of the children had ≥1 measure of haemoglobin available in those exposed to ZDV versus 60.4% of those not (p=0.45. Severe anaemia occurred in 92 children with an incidence of 2.47 per 100 child-years of follow-up in those on a ZDV-containing regimen versus 4.25 in those not (p≤0.01. Adjusted for age at ART initiation and first-line regimen, a weight-for-age z-score ≤−3 was a strong predictor associated with a 5.59 times risk of

  19. 面向IED的变电站通信软件设计与实现%Design and implementation of substation communication software for IED

    Institute of Scientific and Technical Information of China (English)

    胡凤凯; 黄琦; 井实; 李静

    2011-01-01

    With the development of smart grid, Intelligent Electronic Device (IED) will be increasingly used in substation protection, control and measurement. A kind of substation communication software for variety of IEDs is designed and implemented. This paper focuses on the overall flow of the system, function library, multithreading architecture, and the design of database. This software utilizes the Modbus TCP/IP which is an openly published, efficient, and widely used communication protocol in the industrial automation field. In order to make the system have a strong scalability, this paper also describes the implementation guide of Modbus based on IPv6. Finally, the performance of the library and the real time capability of the overall system are tested respectively, indicating that this software meets the requirements of being efficient and stable, reliable in the communication of substation.This work is supported by the Fundamental Research Funds for the Central Universities (No. ZYGX2009X014) and the Program for New Century Excellent Talents in University (No. NCET-09-262).%随着智能电网的发展,智能电子设备(Intelligent Electronic Device,IED)将会越来越多地应用于变电站中的保护、控制和测量领域.设计并实现了与变电站多种lED进行高效率数据通信的软件,重点包括软件的总体流程、函数库、多线程架构以及数据库各功能模块的设计方案.系统选择了开放性较好和效率较高、并在工业自动化领域中广泛应用的Modbus TCP/IP作为通信协议.为了让系统具备较强的可扩展性,研究了IPv6上的Modbus实现方案.并分别对函数库的性能以及整体系统的实时性进行了测试,结果表明软件系统满足了变电站通信中高效、稳定、可靠的要求.

  20. Plan de formación en comprensión lectora en el I.E.S. Américo Castro

    Directory of Open Access Journals (Sweden)

    Ana Isabel Eleuterio Plata

    2015-01-01

    Full Text Available El artículo trata de mostrar de forma general los principales problemas de comprensión lectora con que nos encontramos en los centros escolares. En concreto en el centro de Educación Secundaria IES Américo Castro, son bastantes frecuentes este tipo de problemas, que el alumnado no comprende lo que lee le repercute de forma negativa en la realización de todo tipo de actividades (exámenes, tareas, etc. y en todas las áreas o materias. Es por eso que el artículo resume las principales actuaciones que se llevan a cabo en el centro, sobre todo a través del Plan de Lectura, para intentar paliar este tipo de dificultades. La mayoría de estas propuestas están basadas en tres ejes: una metodología dinámica, lúdica y motivadora para el alumnado; la colaboración de todos los profesores/as y todos los departamentos y, sobre todo, partir de los intereses y las motivaciones de nuestro alumnado para fomentar el hábito lector como base de la competencia lectora.

  1. Atmospheric aerosols parameters behavior and its association with meteorological activities variables over western Indian tropical semi-urban site i.e., Udaipur

    Science.gov (United States)

    Vyas, B. M.; Saxenna, Abhishek; Panwar, Chhagan

    2016-05-01

    The present study has been focused to the identify the role of meteorological processes on changing the monthly variation of AOD at 550nm, Angstrom Exponent Coefficient (AEC, 440/670nm) and Cloud Effective Radius (CER, μm) measured during January, 2005 to December 2013 over western Indian location i.e., Udaipur (24.6° N, 73.7° E, 560 m amsl). The monthly variation of AOD 550nm, AEC and during entire study period have shown the strong combined influence of different local surface meteorological parameters in varying amplitude with different nature. The higher values of wind speed, ambient surface temperature, planetary boundary layer, and favorable wind direction coming from desert and oceanic region (W and SW) may be recognize as some of possible factor to exhibit the higher aerosols loading of bigger aerosol size particles in pre-monsoon. These meteorological factors seem also to be plausible responsible factors for drastically reducing the cloud effective radius in pre-monsoon season. In contrary to this, in winter, lower atmospheric aerosols burden and more abundance of fine size particles along with increasing the CER sizes also seem to be influenced and governed by the adverse nature of meteorological conditions such lowering the PBL, T, WS as well as with air pollutants transportation by wind from the N and NE region, of high aerosols loading of fine size particles as anthropogenic aerosols located far away to the observing site.

  2. Valūtas maiņas kursi - fiksētie un peldošie. Pozitīvie un negatīvie aspekti.

    OpenAIRE

    Stārastniece, Renāte

    2010-01-01

    Bakalura darba tēma ir „Valūtas maiņas kursi - fiksētie un peldošie. Pozitīvie un negatīvie aspekti”. Darba mērķis - izpētīt fiksēta, peldoša valūtas kursa veidošanās mehānismus, atšķirības, ietekmi uz tautsaimniecību. Darbs sastāv no ievada, trim nodaļām, secinājumiem un priekšlikumiem. Darba pirmajā nodaļā - ieskats starptautiskās valūtas sistēmas attīstībā, fiksēta, peldoša valūtas kursa režīmu izveidē, kā arī apskatīti fiksēta peldoša valūtas kursa noteikšanas principi. Darba otrā nodaļa ...

  3. Determination of nitrate by the IE-HPLC-UV method in the brain tissues ofWistar rats poisoned with paraquat

    Directory of Open Access Journals (Sweden)

    MARIJANA CURCIC JOVANOVIC

    2007-04-01

    Full Text Available This work was a part of an initial study regarding the involvement of reactive nitrogen species (RNS in paraquat (PQ neurotoxicity. The nitrate concentration in the vulnerable regions of the brain (cortex, striatum and hippocampus of Wistar rats was used as a measure of nitric oxide (NO production or catabolism of the formed RNS. The tissue homogenates were deproteinized with acetonitrile and then centrifuged. Nitrate was measured in filtrated supernatants by simple and rapid isocratic ion-exchange high performance liquid chromatography with UV detection (IE-HPLC-UV at 214 nm. The mobile phase (pH 8.5 consisted of borate buffer/gluconate concentrate, methanol, acetonitrile and deionized water (2:12:12:74, v/v/v/v, and the flow rate was 1.3 mL/min. Physiological nitrate levels (18.8 ± 6.1 nmol/mg of proteins, as well as a diverse range of nitrate concentrations could be determined with good precision (CV = 2.2 % and accuracy (recovery of spiked samples was 99 ± 4% in the brain tissue homogenates. Linearity was achieved in the range of nitrate from 0‑80 mM. The retention time of nitrate anion was 5.3 ± 0.3 min.

  4. Meta-análise das publicações científicas de IES brasileiras com Sistema de Gestão Ambiental

    Directory of Open Access Journals (Sweden)

    Alexandre André Feil

    2015-01-01

    Full Text Available The Higher Education Institutions (HEIs are being pressured by changes towards sustainability and thus awakening to environmental management, they are considered as a leader in promoting sustainability through actions and environmental management practices. Following this logic, this study aims to identify the environmental management practices used in Brazilian HEIs and correlations exist that influence the implementation of Environmental Management Systems (EMS. The quantitative approach is applied through documentary research with secondary data published in proceedings, journals, books and portal Scientific Electronic Library (SciELO. The data analysis occurred through meta-analysis using descriptive statistics and Spearman correlation. The results of 34 scientific studies 23 IES referencing models and practices of waste management published from 2001 to 2012 were identified. The Spearman correlation analysis expressed that HEIs with programs in environmental education performed better ranking General Index of Courses. It is recommended that HEIs that have a waste management deployed, share your experience through scientific publications to disseminate their adaptation practices regarding the SGA.

  5. PRACTICAL EXPERIENCE OF REGIONAL PEOPLE'S CONTROL AUTHORITIES OF MOSCOW IN THE CONSTRUCTION INDUSTRY AIMED AT THE IMPROVEMENT OF THE MUNICIPAL ECONOMY IN THE 1980ies

    Directory of Open Access Journals (Sweden)

    Byzov Aleksey Yur'evich

    2012-10-01

    Full Text Available In the article, the author has proven that state control authorities had an important function in the organizational structure of the government authorities of our country. The author also drives attention to the fact that, in the Soviet period, government leaders implemented the idea of a system of controlling authorities that were to a substantial extent composed of blue collars. An extensive network of controlling authorities operating on location was active in the 80ies of the 20th century. The historical experience of regional controlling authorities is considered in article, and Moscow controlling authorities are taken as an example. The author demonstrates that the Moscow City Committee, regional committees, groups and posts of people's control organized at enterprises and other organizations drove particular attention to the issues of construction, the building industry as a whole and to the accomplishments of the municipal economy; they also supervised over the implementation of ecological and nature protection actions, monitored the condition and repairs of public health service buildings; they resolved the issues of education, culture, available housing, housing preparation for the winter season, etc. Actions taken in the aftermath of inspections held by people's control authorities were aimed at the improvement of the ecological condition of Moscow, and they resolved the problems of urban construction. Multiple assignments performed by people's control authorities made it possible to substantially improve the quality of their inspections and to combine the controlling efforts within the framework of the municipal economy. Coordination of combined inspections promoted reduction in the overall number of inspections. The present-day building sector of the Russian capital can benefit from the experience of Moscow people's control authorities, their well-coordinated controlling activities within the construction industry and the prior

  6. IE技术在货代业务流程优化中的应用%Application of IE Technologies to the Business Process Reengineering of a Forwarder

    Institute of Scientific and Technical Information of China (English)

    乐泓; 陈俊

    2011-01-01

    运用工业工程技术,对某货代公司的业务流程进行了分析和改进,将传统的“粗放型”操作模式,即按客户分工、一票业务由个人全程负责,转变成由前台提供个性化服务和后台进行标准化操作相结合的“精细型”模式,制定了标准操作流程和岗位说明书,通过工作研究减少无效操作,配合新流程的要求,对管理信息系统进行改造,提高了工作效率和客户满意度.%The business process reengineering issue for a forwarder is studied in this paper. Traditionally, a customer order is processed with the out-of-date way by just one person from the beginning to the end through the whole business process, leading to low productivity and low service quality. A number of industrial engineering(IE)technologies are used to analyze this process. Based on the analysis, the business process is reengineered. The new process is divided into two parts: the front and back ends. In the former, it provides customized service. In the latter, the business process is standardized, and tasks are clearly identified and described. Then, work study is conducted to eliminate redundancy tasks. To support the operation of the new process, the management information system is updated. As a result, both work efficiency and customer satisfaction are significantly improved.

  7. IE在家电制造业供应链系统研究案例%Case Study of Applying IE to Household Appliance Manufacturing Supply Chain

    Institute of Scientific and Technical Information of China (English)

    张泉伟; 廖加发

    2012-01-01

    随着全球范围内市场竞争的加剧与市场需求的多元化,家电企业竞争的焦点将是如何以更低的成本和更快的市场响应速度赢得市场.C公司作为传统家电制造企业,市场覆盖遍及全球,供应链范围涉及面广;本文利用IE流程改善的思想,结合C公司的供应链现状,对供应链系统中的销售需求预测、采购管理、生产计划、仓储物流管理进行全面系统的改善,实现供应链系统的闭环无缝衔接,提升供应链效率,对市场需求作出快速响应,降低成本.%With global market competition and market demand diversification, the focus of competition of home appliance enterprises has become how to response the market change with lower cost and faster speed. As a traditional home appliance manufacturer, C Company's market has spread across the whole world, and its supply chain has a wide range. By IE process improvement, combining with its situation, the article makes a improvement for sales demanding forecast, purchasing management, production planning, and warehousing and logistics management of supply chain systems, realizing the closed-loop supply chain system and improving supply chain efficiency, responding quickly to market demands and reducing costs.

  8. The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells

    Science.gov (United States)

    Heilingloh, Christiane S.; Grosche, Linda; Kummer, Mirko; Mühl-Zürbes, Petra; Kamm, Lisa; Scherer, Myriam; Latzko, Melanie; Stamminger, Thomas; Steinkasserer, Alexander

    2017-01-01

    Human cytomegalovirus (HCMV) is the prototypic beta-herpesvirus and widespread throughout the human population. While infection is asymptomatic in healthy individuals, it can lead to high morbidity and mortality in immunocompromised persons. Importantly, HCMV evolved multiple strategies to interfere with immune cell function in order to establish latency in infected individuals. As mature DCs (mDCs) are antigen-presenting cells able to activate naïve T cells they play a crucial role during induction of effective antiviral immune responses. Interestingly, earlier studies demonstrated that the functionally important mDC surface molecule CD83 is down-regulated upon HCMV infection resulting in a reduced T cell stimulatory capacity of the infected cells. However, the viral effector protein and the precise mechanism of HCMV-mediated CD83 reduction remain to be discovered. Using flow cytometric analyses, we observed significant down-modulation of CD83 surface expression becoming significant already 12 h after HCMV infection. Moreover, Western bot analyses revealed that, in sharp contrast to previous studies, loss of CD83 is not restricted to the membrane-bound molecule, but also occurs intracellularly. Furthermore, inhibition of the proteasome almost completely restored CD83 surface expression during HCMV infection. Results of infection kinetics and cycloheximide-actinomycin D-chase experiments, strongly suggested that an HCMV immediate early gene product is responsible for the induction of CD83 down-modulation. Consequently, we were able to identify the major immediate early protein IE2 as the viral effector protein that induces proteasomal CD83 degradation. PMID:28203230

  9. Low implementation of Xpert MTB/RIF among HIV/TB co-infected adults in the International epidemiologic Databases to Evaluate AIDS (IeDEA) program

    Science.gov (United States)

    Blevins, Meridith; Lindegren, Mary Lou; Yotebieng, Marcel; Nguyen, Dung Thi; Omondi, Alfred; Michael, Denna; Zannou, Djimon Marcel; Carriquiry, Gabriela; Pettit, April

    2017-01-01

    Objective Xpert MTB/RIF is recommended by the World Health Organization (WHO) as the initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation of Xpert among a cohort of HIV/TB co-infected individuals, including availability, utilization and outcomes. Design Observational cohort study (patient-level data) and cross-sectional study (site-level Xpert availability data). Methods Data were collected at 30 participating International epidemiologic Databases to Evaluate AIDS (IeDEA) sites in 18 countries from January 2012-January 2016. All patients were HIV-infected and diagnosed with TB, either bacteriologically or clinically, and followed until a determination of TB treatment outcome. We used multivariable modified Poisson regression to estimate adjusted relative risk (RR) and 95% confidence intervals for unfavorable TB treatment outcomes. Results Most sites (63%) had access to Xpert, either in the clinic (13%), in the same facility (20%) or offsite (30%). Among 2722 HIV/TB patients included, median age was 35.4 years and 41% were female; BMI and CD4 count were low. Overall, most patients (76%) received at least one TB test; 45% were positive. Only 4% of all patients were tested using Xpert: 64% were Xpert-positive, 13% showed rifampicin (RIF) resistance and 30% were extrapulmonary (EPTB) or both pulmonary-EPTB. Treatment outcomes were mostly favorable (77%) and we found little association between Xpert use and an unfavorable TB treatment outcome (RR 1.25, 95%CI: 0.83, 1.90). Conclusions In this cohort, Xpert utilization was low even though the majority of sites had access to the test. Our findings show the need for expanded implementation and further research exploring barriers to use in low-resource settings. PMID:28182705

  10. VERIFICAREA AUTENTICITĂȚII INFORMAȚIONALE A PURTĂTORILOR TEHNICO-ELECTRONICI DE INFORMAȚIE ÎN PROBATORIUL PENAL

    Directory of Open Access Journals (Sweden)

    Elena CROITOR

    2017-07-01

    Full Text Available Probatoriul penal presupune etape și elemente de a căror respectare depinde, indubitabil, justa soluționare a cauzei penale. Codul de procedură penală în vigoare reglementează cu titlu de obligație a subiectului oficial, care administrează și apreciază proba, verificarea acesteia din punctul de vedere al veridicității. Totodată, în virtutea varietăților sub care se prezintă purtătorii tehnico-electronici de informație, pe de o parte, și datorită complexității activității de dobândire și introducere în proces, pe de alta, activitatea de verificare depășește limitele procesului penal, realizând incursiuni nu doar în criminalistică, ci și în tehnică.Astfel, pornind de la cele enunțate, verificarea se realizează atât din perspectivă procesuală, cât și din punctul de vedere al condițiilor de ordin tehnic, de care depinde nu doar autenticitatea, cât, mai ales, admisibilitatea probei.Diferite genuri ale expertizei criminalistice permit, la etapa actuală, identificarea existenței unor manipulări de oarecare natură în conținutul înregistrării audio-video fixate pe un anumit suport tehnico-electronic de informație, indiferent dacă au fost realizate prin montaj, prin adăugarea sau excluderea textului, fie prin intervenții de alt fel. Pe de altă parte, falsul intelectual devine detectabil, în principal, prin intermediul unei verificări procesuale, altfel spus – prin aprecierea probelor în colaborare sau prin realizarea unor procedee probatorii. Faptul dat nu exclude posibilitatea identificării unor indicii în acest sens, prin intermediul unor expertize tehnice, fonoscopice, computerizate şi al., care ar pune la îndoială rezonabilă autenticitatea probelor electronice administrate pentru soluționarea cauzei penale.THE AUTHENTICITY VALIDATION OF THE INFORMATION PROVIDED BY ELECTRONIC DATA CARIRERS IN CRIMINAL PROCEEDINGSFor the fair settlement of the criminal case, the criminal procedural

  11. TINIA检测HbA1c的性能评价及和IE-HPLC在HbE患者中的应用比较%Evaluation and comparison on the performance of detecting HbA1c by TINIA method and IE-HPLC method in HbE patients

    Institute of Scientific and Technical Information of China (English)

    温冬梅; 阚丽娟; 周甲思; 张秀明; 王伟佳; 陈亚琼; 索明环; 徐全中; 吴剑杨; 李曼; 萧金丽

    2014-01-01

    目的:评价免疫抑制比浊法(TINIA)检测糖化血红蛋白(HbA1c )的分析性能,与离子交换高效液相色谱法(IE-HPLC)检测HbA1c进行比对和偏倚评估,并评估血红蛋白(Hb)变异体E(HbE)对TINIA和IE-HPLC的影响。方法参考美国临床与实验室标准化协会(CLSI)发布的方法学评价系列文件(EP文件)及有关文献,对TINIA检测HbA1c的精密度、正确度、分析测量范围、分析干扰以及生物参考区间进行评价和验证,对TINIA与IE-HPLC检测Hb结构正常的血液样本和含HbE的血液样本进行对比分析和偏倚评估,分析患者平均血糖的相关性。结果 TINIA检测HbA1c的批内精密度<2.08%,总不精密度<2.94%;在HbA1c浓度为4.4%~18.3%范围内,理论值与实测均值呈线性相关(r=0.9994);Hb、游离胆红素(FBiL)、结合胆红素(CBiL)、乳糜(CH)浓度分别为9.9~49.6μmol/L、65.6~328.0μmol/L、65.6~328.0μmol/L和3000~12000 FTU时,差异百分比均<5%;厂商提供的参考区间(4.8%~5.9%)适用于临床实验室。对于Hb结构正常的血液样本,TINIA和IE-HPLC的HbA1c检测结果差异无统计学意义(P>0.05),两种方法的相关性良好(r2=0.9992)。对于HbE浓度在5.4%~54.7%范围内的血液样本,TINIA的平均偏倚为-4.1%~1.9%,均<5%,几乎不受HbE 的干扰, HbA1c检测结果与平均血糖的相关性较好(r=0.9988);当HbE>6.4%时IE-HPLC检测HbA1c的实测值与理论值平均偏倚为5.7%~278.7%,差异百分比均>5%,测定结果与预期理论结果有明显差异;两种方法检测结果差异有统计学意义(P<0.01)。结论 TINIA检测HbA1c的分析性能符合临床测定的性能要求,不受HbE的干扰。当HbE>6.4%时,IE-HPLC法检测HbA1c会受干扰,出

  12. Counter-IED Initiative PPE Horizon 0, Phase 1, Protection Versus Performance Preliminary Trade-off Analysis, Behavioural Task Analysis (Initiative d’epi pour la Lutte aux IED - Horizon 0 Phase 1 - Analyse de Compromis Preliminaire de la Protection par Rapport au Rendement Analyse Comportementale des Taches)

    Science.gov (United States)

    2007-05-01

    fournit les connaissances spécialisées en ergonomie pour soutenir ce projet. Afin de formuler des recommandations relativement à l’EPI pour corriger...important. RDDC Toronto fournit les connaissances spécialisées en ergonomie pour soutenir ce projet. Afin de formuler des recommandations relativement à...Programme de démonstration de technologie (PDT) de C−IED plus important. RDDC Toronto fournit les connaissances spécialisées en ergonomie pour soutenir

  13. Des Taiwanais dans Ie sud du Fujian

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Se trouvant dans le sud-est de la Chine au bord dela mer, la province du Fujian s’appelle aussi toutsimplement "Min". Les anc(?)tres d’une grande partie de lapopulation de Taiwan sont venus du Fujian (Min). Les deux

  14. Modern Resource-Based Theory(ies)

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Stieglitz, Nils

    We survey the resource-based view in strategic management, focusing on its roots in economics. We organize our discussion in terms of the Gavetti and Levinthal distinction between a “high church” and a “low church” resource-based view, and argue that these hitherto rather separate streams...

  15. OFICIUL EUROPEAN DE POLIŢIE - EUROPOL

    Directory of Open Access Journals (Sweden)

    Angelica Chirila

    2008-05-01

    Full Text Available Europol is the European Law Enforcement Organisation which aims at improving theeffectiveness and co-operation of the competent authorities in the Member States in preventing and combatingterrorism, unlawful drug trafficking and other serious forms of international organised crime.The establishment of Europol was agreed in the Maastricht Treaty on European Union of 7 February1992. Based in The Hague, Netherlands, Europol started limited operations on 3 January 1994 in the form of theEuropol Drugs Unit (EDU fighting against drugs. Progressively, other important areas of criminality wereadded. On 1 January 2002, the mandate of Europol was extended to deal with all serious forms of internationalcrime as listed in the annex to the Europol Convention. The Europol Convention was ratified by all MemberStates and came into force on 1 October 1998. Following a number of legal acts related to the Convention,Europol commenced its full activities on 1 July 1999.

  16. INDESTRUCTIBILA RELAŢIE TURISM - DEZVOLTARE DURABILĂ

    Directory of Open Access Journals (Sweden)

    Puiu NISTOREANU

    2007-06-01

    Full Text Available The sustainable development in tourism is a necessity, taking into account the fact that the economy and the environment are facets of the same coin, in other words, the two are strongly linked and interdependent. The place of tourism in the sustainable development is given by its role as an industry which sells the physical and human environment as its products. Of course the tourism is one of the industries which has to get involved in the sustainable development, as an industry of resources, dependent of nature’s endowment and of the cultural heritage of each society; the tourism sells these resources as a part of its product, and, in the same time, shares certain resources with other users, including the local population. The sustainable tourism develops the idea of satisfying the current tourists and the touristic industry, and in the same time, of protecting the environment and opportunities for the future. We take into consideration satisfying all the economical, social and esthetical needs of the actors in tourism while maintaining the cultural and ecological integrity, the biologic diversity and all that supports life.

  17. Situation of Nation's Chemical I/E

    Institute of Scientific and Technical Information of China (English)

    Chen Bin

    2001-01-01

    @@ The year of 2000 saw the nation's chemical industry achieving a total of 49.317 billion worth of import and export, an increase of 25% over the previous year (based on custom statistics).That was a year of the biggest increment in this regard during the "9th Five-Year Plan" period, with the export hitting US$17.263billion, up 19.5% on a year-on-year basis, and the import soaring US$32.054 billion, up 48% year-on-year. The total import and export of petrochemical products in 2000 amounted to US$74.09 billion, going up by 48% as compared with the previous year,of which the import valued US$21.84 billion, a year-on-year increase of 32.11%, and export,US$52.25, up 53.36%.

  18. Industrial Ecology (IE) Revisited: Beyond Environmental Myopia

    DEFF Research Database (Denmark)

    Bojsen, Inger; Ulhøi, John Parm

    Since the late 1980s, the notion of industrial ecology has attracted increasing attention amoung researchers, most notably in the US and northern Europe. However, this is not yet translated into any significant political or practical awareness in the industrial community. There are several reasons...

  19. Succession Planning Demystified. IES Report 372.

    Science.gov (United States)

    Hirsh, W.

    This book, which is designed for human resource (HR) practitioners, details the principles and applications of succession planning, shows how succession planning is conducted, and explains its place in relation to other HR processes and business priorities. The introduction describes the book's intended audience and provides a brief overview of…

  20. The origin of the ie endingless locative

    Directory of Open Access Journals (Sweden)

    Kenneth Shields

    1979-12-01

    Full Text Available In this paper is presented a new hypothesis regarding the development of the so-called "endingless locative" construction of Indo-European. It is argued that locative formations in -ē, and * ī came to appear in the , o-stem nouns through the monophthongization of word-final *-oi and *-ei before word-initial consonants. These formations were analogically extended to the other stem-classes, with the suffix*-ē, frequently hypercharacterized by the locative particles *-i or *-u, becoming the primary marker of the locative function in the i- and u-stems. On the basis of such apparently "endingless" locative constructions, old consonant-stem nominative (-accusative formations in were reinterpreted as locatives as well.

  1. Antisocial behavior: Dimension or category(ies?

    Directory of Open Access Journals (Sweden)

    Biro Mikloš

    2008-01-01

    Full Text Available Classificatory systems (DSM-IV, ICD-10 use different criteria for defining a rather common antisocial disorder, traditionally referred as psychopathy. Most empirical studies of this phenomenon use Cleckley's operational definition that was applied and amended in Hare's revised Psychopathy Checklist (PCL-R. In modern literature, the fact that there is less than a perfect correspondence between classificatory systems and Hare's PCL-R is often cited as an indication that antisocial behavior is not confined to a distinct category of people but is rather a continuous personality dimension. In order to further elucidate the nosology of antisocial behaviors, a Psychopathy Assessment Questionnaire (PAQ based on Cleckley - Hare's criteria and consisting of 40 binary items was administered to 339 men (135 prisoners and 204 members of the general population. Four distinct clusters of respondents were identified by means of hierarchical cluster analysis: Psychopathic type (characterized by high positive scores on dimension of Unemotionality; Antisocial type (characterized by high positive scores on Social deviance dimension; Adapted type (characterized by negative scores on all dimensions; and Hyper-controlled type (characterized by extremely negative scores on dimension Social deviance accompanied with positive scores on Unemotionality dimension. Additional comparison with MMPI profiles which classified prison sample in two groups ("Psychopathic profiles" and "Non- Psychopathic profiles" shows that there is no expected compatibility between MMPI and PAQ. We conclude that Antisocial type can be treated as a distinct category, while Psychopathic type displays characteristics of dimensional distribution.

  2. La relació família-IES: un estudi des de la perspectiva dels pares i de les mares The family-secondary school relationship: a study from the parents’ perspective La relación familia-IES: un estudio desde la perspectiva de los padres y de las madres

    Directory of Open Access Journals (Sweden)

    Mercè Pañellas Valls

    2009-01-01

    Full Text Available La família i l’escola són els dos espais socialitzadors per excel·lència dels infants i dels adolescents i, per tant, la coresponsabilitat d’ambdós en la seva educació és un compromís que s’ha de donar en un clima de confiança i sintonia. Tanmateix, la relació família-escola pot resultar difícil. Atesa aquesta circumstància, s’ha fet l’estudi que aquí es presenta amb els objectius d’analitzar, des del punt de vista de les famílies i dels seus representants a les AMPA, la relació dels pares i mares d’alumnes d’ESO amb l’Institut i oferir elements de reflexió i de millora de la participació. S’estudien sis categories: l’acollida i els canals de comunicació, les entrevistes amb el tutor, les reunions de grup classe, els òrgans institucionals de participació, les activitats de l’IES o de l’AMPA, i l’obertura de l’institut a l’entorn. _____________________________________________ La famille et l’école sont les deux espaces socialisateurs des enfants et des adolescents par excellence et, par conséquent, la coresponsabilité des deux dans leur éducation est un engagement qui doit être offert dans un climat de confiance et de syntonie. Pourtant, la relation famille-école peut parfois être difficile. Compte tenu de cette circonstance, une étude a été faite qui est présentée ici. Elle avait pour but d’analyser, du point de que des familles et de leurs représentants dans les associations de parents d’élèves (AMPA, la relation qui existe entre les parents d’élèves de l’Enseignement secondaire obligatoire (ESO avec les centres scolaires, d’une part, et d’offrir des éléments de réflexion et d’amélioration de la participation, d’autre part. Six catégories ont été étudiées : l’accueil et les canaux de communication ; les entrevues avec les tuteurs ; les réunions du groupe-classe ; les organes institutionnels de participation ; les activités des centres ou de l

  3. POLÍTICAS E INCENTIVOS AO EMPREENDEDORISMO EM INSTITUIÇÕES DE ENSINO SUPERIOR (IES - UMA NOVA ABORDAGEM PARA A GESTÃO EDUCACIONAL [doi: 10.5329/RECADM.20030201006

    Directory of Open Access Journals (Sweden)

    Günther Lother Pertschy

    2003-05-01

    Full Text Available RESUMO Este artigo aborda as principais bases do empreendedorismo, as características preponderantes do empreendedor e a relação desses últimos com as instituições de ensino superior (IES. Advogamos aqui o empreendedorismo, como uma vantagem competitiva quando bem desenvolvido por meio de políticas e incentivos de amplo espectro e de fontes diversas. Discutimos aqui um rol de políticas e diferentes formas de incentivo ao empreendedorismo em IES. Esta análise nos permite concluir que o desenvolvimento e expansão das IES, hoje, dependem mais de uma atitude empreendedora, ou um movimento empreendedor de dentro para fora, lastreado em parcerias devidamente planejadas, na excelência ou qualidade de seus produtos/serviços e na visão do negócio educacional como sustentação da educação, do que na simples racionalização de seus custos operacionais. Por fim, mostramos que atitude empreendedora traz vantagens competitivas inigualáveis para as IES, especialmente para as chamadas "Faculdades Integradas e Isoladas", mais ágeis, com estruturas enxutas e menos custosas. Palavras-chave:empreendedor; empreendedorismo; empreendedorismo e IES; políticas e empreendedorismo; incentivo ao empreendedorismo

  4. Construction of recombinant pseudorabies viruses by using PRV BACs deficient in IE180 or pac sequences: Application of vBAC90D recombinant virus to production of PRV amplicons.

    Science.gov (United States)

    Lerma, L; Muñoz, A L; Wagner, S; Dinu, M; Martín, B; Tabarés, E

    2016-02-02

    We describe a simple and efficient method to obtain recombinant pseudorabies virus (PRV) in mammalian cells by using the PRV BACs, PBAC80 deficient in pac sequences and PBAC90 deficient in the IE180 gene. These essential viral sequences were used as targets to obtain viable recombinant viruses. PBAC80 was constructed, confirmed to encode a copy of the IE180 gene regulated by the inducible Ptet promoter, and used to obtain recombinant attenuated PRV viruses that express the EGFP protein (PRV-BT80GF virus). PBAC90 was used to obtain the vBAC90D virus, deficient in IE180 and free of replication-competent revertants, and which can be used as a helper in the production of PRV amplicons. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Divulgación on-line de los códigos de buen gobierno en las IES y su determinación para el posicionamiento en el ranking QS

    OpenAIRE

    Méndez Beltrán, Jairo Andrés

    2015-01-01

    Dado el interés que se presenta con los temas de gobierno corporativo, este trabajo busca describir si la divulgación on-line de los contenidos de los códigos de buen gobierno, es determinante en el posicionamiento que tienen las Instituciones de Educación Superior (IES) en el ranking QS. Partiendo de una muestra de 20 IES, se recolectaron un conjunto de datos dicotómicos para 30 variables independientes y se relacionaron con la variable dependiente denominada posicionamiento en el ranking. A...

  6. Sistemos “Sunkiųjų metalų jonai - geležies (III) oksidas/hidroksidas“ cheminė analizė ir sorbcijos procesų tyrimas

    OpenAIRE

    Zubrytė, Edita

    2016-01-01

    Sistemos “Sunkiųjų metalų jonai - geležies (III) oksidas/hidroksidas“ cheminė analizė ir sorbcijos procesų tyrimas Chemical Analysis of the System „Heavy Metal Ions – an Iron (III) Oxide/Hydroxide and Investigation of the Sorption Processes

  7. Fault Feature Extraction Method of Gear Based on Improved Local Mean Decomposition and Instantaneous Energy Distribution-sample Entropy%基于改进LMD和IED-SampEn的齿轮故障特征提取方法

    Institute of Scientific and Technical Information of China (English)

    孟宗; 王亚超; 胡猛

    2016-01-01

    提出基于改进的局部均值分解(Local mean decomposition, LMD)和瞬时能量分布(Instantaneous energy distribution, IED)-样本熵(Sample entropy, SampEn)的齿轮故障特征提取方法。针对LMD存在的端点效应问题,提出最大相似系数法改进的LMD方法,该方法通过在信号内部寻找与两端指定波段相似系数最大的波段,来实现端点效应的改善。进行仿真验证,结果表明该方法能有效改善LMD的端点效应问题。采用改进的LMD方法分解信号得到瞬时幅值函数,由此可以获得信号的瞬时能量分布,将其作为样本熵输入获得IED-SampEn,通过试验研究并与PF-SampEn进行对比,结果表明IED-SampEn能够合理地、有效地反应齿轮的故障状态,作为齿轮振动信号的特征矢量具有典型性,可以作为一种有效的故障特征。%A method of gear fault feature extraction based on an improved local mean decomposition (LMD) and instantaneous energy distribution (IED) - sample entropy (SampEn) is proposed. Aiming at end effects of LMD, the maximum similarity coefficient improved LMD method is put forward. The method achieves the improvement of end effect by looking for bands that have the biggest similarity coefficient to the specified bands at both ends in the internal signal. The simulation results show that this method can effectively improve the end effect of LMD. Using the improved LMD to decompose the signal can get instantaneous amplitude functions, from that, instantaneous energy distributions of the signal as sample entropy input of IED-SampEn can be obtained. Through the experimental study and compared with PF-SampEn, the results show that IED-SampEn can reasonably and effectively response gear fault state, it is typical as the feature vector of gear vibration signal and can be used as an effective fault feature.

  8. Los límites de la inversión extranjera direct (IED como fuente de ideas para el crecimiento de las economías en desarrollo

    Directory of Open Access Journals (Sweden)

    Cédric Durand

    2005-01-01

    Full Text Available El artículo es un estudio conceptual de la relación entre inversión extranjera directa (IED, productividad y crecimiento en las economías en desarrollo. Se discute la afirmación de Romer, según la cual la presencia de las empresas transnacionales permite reducir la brecha de ideas que deja en la pobreza a los países en desarrollo. A partir de una presentación de los mecanismos que permiten una relación virtuosa entre dicha inversión como fuente de ideas, se proponen dos hipótesis. La primera sugiere que existen diferentes condiciones que afectan el efecto neto de la IED sobre la economía receptora y se debe considerar el riesgo de una dinámica perversa. La segunda supone que los determinantes del impacto de la IED son la estructura de la cadena de valor considerada y las configuraciones institucionales en las cuales ocurre la mencionada inversión.

  9. PEDAGOGIA ÎNVĂŢĂRII PRIN INVESTIGAŢIE ŞI IMPACTUL EI ASUPRA DEPRINDERILOR DE CERCETARE ŞTIINŢIFICĂ ŞI ÎNVĂŢARE PE TOT PARCURSUL VIEŢII

    Directory of Open Access Journals (Sweden)

    Mihail CALALB

    2017-07-01

    Full Text Available În lucrare sunt analizate particularităţile de bază ale metodei de învăţare prin investigaţie. Se menţionează că învăţarea prin investigaţie este o pedagogie constructivistă, care, după structura ei, este similară învăţării pe bază de proiect şi învăţării problematizate. Doar atribuind elevului rolul principal în binomul profesor-elev poate fi atins obiectivul de for­mare a conceptului ştiinţific despre lume. Se subliniază că deprinderile de cercetare ştiinţifică, formate în cadrul aplicării permanente a învăţării prin investigaţie, sunt acele deprinderi ce stau la baza învăţării pe tot parcursul vieţii. Deprinderile de interacţiune socială, formate în cadrul lucrului în grup, şi deprinderile de comunicare sunt elemente distinctive ale învă­ţării prin investigaţie. Un alt beneficiu major adus de învăţarea prin investigaţie pentru dezvoltarea pe termen lung a personalităţii elevului este formarea vocabularului ştiinţific activ.THE PEDAGOGY OF INQUIRY – BASED SCIENCE EDUCATION AND ITS IMPACT ON SCIENTIFIC RESEARCH AND LIFELONG LEARNING SKILLSThe main features of inquiry – based science education (IBSE are analyzed in this paper. It is shown that IBSE is a constructivist pedagogy which, according to its structure, is similar to project – based and problem – based learning. It is emphasized that one of the most important goal of education – the formation of the scientific concept about the world – may be reached only if the main role in the binomial “student – teacher” is assigned to the students. It is demonstrated that the scientific research skills, formed within permanent application of IBSE in the classroom, are namely those skills which determine the efficiency of lifelong learning. Social interaction skills built within group work and communicative skills are the distinctive features of IBSE. The formation of active scientific vocabulary is another major

  10. Cry1Ie蛋白的模拟胃肠液消化稳定性及热稳定性分析%Analysis of Digestive Stability in Simulative Digestive Tract Fluid and Heat Stability of Cry1Ie Protein

    Institute of Scientific and Technical Information of China (English)

    李欣竹; 耿丽丽; 高继国; 张杰

    2015-01-01

    Cry1Ie蛋白对亚洲玉米螟(Ostrinia furnacalis)具有高毒力,cry1Ie基因已经应用于转基因抗虫玉米的种质创制。为评价Cry1Ie蛋白的食用安全性,开展了Cry1Ie蛋白的消化及热稳定性研究。利用实验室已经构建的表达载体,在大肠杆菌中表达了分子量为81 kD的可溶性Cry1Ie蛋白,经过Ni-NTA亲和层析和Superdex-75分子筛层析获得纯度达91%蛋白。模拟消化液实验结果表明,Cry1Ie蛋白在模拟胃肠液中15 s内即被消化,SDS-PAGE未检测到蛋白残留。热稳定性实验中,Cry1Ie蛋白在玉米粉提取液中不稳定,100℃30 min内蛋白基本降解。对样品进行了生物活性测定发现,经模拟胃肠液消化处理和热处理后的Cry1Ie蛋白对亚洲玉米螟无杀虫活性。Cry1Ie蛋白在胃肠液系统中和热处理条件下均不稳定,并丧失了对亚洲玉米螟的杀虫活性。%Due to the high virulence to Asian corn borer(Ostrinia furnacalis)of Cry1Ie, this protein had applied into the germplasm creating of transgenic insect-resistant maize. To evaluate the food safety of Cry1Ie protein, this study carried out the digestion and heat stability assays. Using the expressing vector which the laboratory has constructed, the Cry1Ie protein(81 kD)was expressed inEscherichia coli, and the high purity protein was obtained using Ni-NTA chromatography and Superdex-75 size-exclusion chromatography. The results of artificial digestion assay showed that Cry1Ie was degraded rapidly within 15 s in simulated gastric fluid and intestinal fluid, without any peptide left in SDS-PAGE. In the heat stability assay, Cry1Ie was not stable in the extracting solution of maize meal, and most was degraded within 30 min under 100℃. In the bioassay of the Asian corn borer(Ostrinia furnacalis), it suggested that Cry1Ie lost the bio-activity after the treatment of digestion and heat. In conclusion, Cry1Ie was not stable in the gastrointestinal fliud and the

  11. Perception, performance, autonomy and working conditions of administration course coordinators in institutions of higher learning (IES in Minas Gerais, Brazil Percepción, actuación, autonomía y condiciones de trabajo de coordinadores del curso de administración de IES del estado de Minas Gerais, Brasil Percepção, atuação, autonomia e condições de trabalho de coordenadores do curso de administração de IES do estado de Minas Gerais

    Directory of Open Access Journals (Sweden)

    Marcos Antônio de Camargos

    2010-09-01

    Full Text Available The activity of coordinating course demand continues to be a theoretical and practical endeavor (Rangel, 2001 in view of the large number of tasks and responsibilities involved although it has received special attention by the academic community. This study identifies and analyzes perception, performance, autonomy and working conditions of those coordinating Administration courses in institutions of higher learning (IES in Minas Gerais state. A sample of 34 coordinators was selected by voluntary participation. Data was collected with 21 survey questions to understand details, subtleties and complications often hidden from visits by MEC. These aspects perpetuate the technical approach to administration that is prejudicial by failing to induce students to think about and develop a capacity for assimilation and understanding of their environment thereby educating a student less capable of improving society.A pesar de haber recibido atención especial de la comunidad académica en los últimos años, la actividad de coordinación de curso demanda todavía una construcción teórica y práctica (RANGEL, 2001, teniendo en vista la gran cantidad de tareas y responsabilidades atribuidas al coordinador. Inserido en esa discusión, este estudio tiene como objetivo identificar y analizar la percepción, actuación, autonomía y condiciones de trabajo de los gestores del curso de Administración de Instituciones de Enseñanza Superior (IES del Estado de Minas Gerais. La investigación fue realizada en una muestra de 34 coordinadores de cursos de Administración de IES de ese Estado, definida por conveniencia (participación voluntaria. Para recolectar los datos se utilizó un cuestionario compuesto de 21 preguntas. Fueron formuladas cuestiones sobre la realidad de esa actividad, con la intención de comprender mejor sus sutilezas y explicitar sus llagas, muchas veces "escondidas debajo de la alfombra" cuando ocurren visitas del MEC. Esas cuestiones son

  12. Institutional Ethnography (IE, Nursing Work and Hospital Reform: IE's Cautionary Analysis

    Directory of Open Access Journals (Sweden)

    Janet Rankin

    2009-03-01

    Full Text Available Hospitals in Canada have been subject to intensive reorganization in the past few decades as the public health care system absorbs and adapts to a neoliberal government agenda that promotes more "efficient and effective" use of public funds and increased involvement on the part of the private sector. A massive infusion of public money for health information technology and health services research has created the capacity to generate objectified knowledge and to use it to reform the health care system—both its organization and, increasingly, its therapeutics—with the promise of making it all work better. The research reported here is on the engagement of professional nurses in their everyday/night work in restructured hospitals and on how nursing practice is being reshaped in consequence. Our research approach, institutional ethnography, focuses on the social organization of health knowledge from the standpoint of those involved in and subordinated to its managerial uses, in this case, the nurses. We argue that a new form of ruling is being deployed. Nurses play an active part in the subordination of their own professional judgment to the objectified knowledge and knowledge-based practices that externalize decision making and reposition authoritative knowing. The paper describes and discusses the conduct of an institutional ethnographic inquiry (RANKIN & CAMPBELL, 2006 and illustrates some of its distinctive features using examples from our research. URN: urn:nbn:de:0114-fqs090287

  13. LabeI Character Recognition Based on Image Composition of DoubIe Light Sources%基于双光源图像合成法的标牌字符识别方法研究

    Institute of Scientific and Technical Information of China (English)

    林笃盛; 吕海堂; 洪涛; 周明华

    2014-01-01

    在电能表标牌 OCR 的识别过程中,标牌上的透明薄膜经常出现皱褶,使得待识别字符极易受到反射光遮挡,从而增加了 OCR 的识别难度和识别错误率。提出一种位置对称的双光源图像合成法,用该方法检测了多个贴有皱褶薄膜层的电能表标牌,经实例验证,相较于单光源的识别错误率大幅度降低,这有效解决了电能表标牌 OCR 中薄膜反光干扰问题。%The Watt-hour meter sign of transparent fiIm often appears corrugated surface during the OCR process,which makes waiting characters are screened by refIected Iight easiIy,increases the difficuIty of OCR recognition and discriminating error rate.This paper presents a symmetricaI site of doubIe Iight sources image composition method,which is used to identify the number of watt-hour meter signs with corrugated surface.It has been verified by exampIes that compared with singIe Iight source reduced greatIy the discriminating error rate,and soIved effectiveIy the watt-hour meter sign OCR of refIective fiIm interference probIem.

  14. La alfabetización informacional en las Universidades-IES peruanas: Visualización de los niveles de incorporación desde la información publicada en los sitios web de sus bibliotecas

    Directory of Open Access Journals (Sweden)

    Alejandro Uribe Tirado

    2011-12-01

    Full Text Available Objetivo. Identificar desde la información disponible en los sitios Web de las bibliotecas de las universidades/instituciones de enseñanza superior (IES del Perú, los niveles de incorporación que estaría teniendo la alfabetización informacional (ALFIN como servicio fundamental y transversal de toda biblioteca en el siglo XXI. Método. Partiendo de los postulados del análisis de contenidos Web, se realiza un proceso investigativo registrando la información recopilada, en primer lugar, en una ficha de contenidos, y posteriormente, en una base de datos que permite realizar el análisis comparativo y la presentación gráfica de los resultados. Resultados. Se identificó que en la actualidad desde la información que se presenta en los sitios Web de las universidades-IES del Perú, un porcentaje muy reducido de bibliotecas universitarias se encontrarían realizando acciones de un nivel 1 ó 2 de incorporación de ALFIN, ya que una gran mayoría se encuentra aún desarrollando programas y procesos muy enfocados a la formación de usuarios tradicional, mientras que otra gran mayoría, desafortunadamente, no presenta ninguna acción-información sobre trabajos desde la perspectiva formadora que debe tener toda biblioteca. Conclusiones. Es necesario aunar esfuerzos entre las bibliotecas de las universidades-IES peruanas para que las más adelantadas apoyen los avances de las otras bibliotecas, y así en el tema de ALFIN, poder trabajar colaborativamente en acciones de formación-autoformación, bechmarking, intercambio de recursos y objetos de aprendizaje, entre otras.

  15. BRINGING YOUTH UP IN BRAVE AND PATRIOTIC SPIRIT BY MEANS OF SPORTS WITH THE SET OF STANDARDS «BE READY TO WORK AND DEFEND YOUR HOMELAND» (GTO STANDARDS SINCE 1917 TO THE 1940-ies

    Directory of Open Access Journals (Sweden)

    Elena Aleksandrovna Istiagina-Eliseeva

    2015-01-01

    Full Text Available The paper considered the Set of Standards for sportive and physical training curricula called « Ready to Work and Defend my Homeland (the USSR» (GTO standards has played the crucial part in the Soviet physical training movement since 1917 to the 1940-ies. In the period prior to the Great Patriotic War the nation had required millions of strong and brave citizens that entailed necessity to set up an integrated physical training strategy meeting new requirements for physical training movement’ advancement. The Set «Ready to Work and Defend my Homeland» (GTO standards enjoyed widespread popularity among the population of the Soviet country. In 1931, 24 thousand athletes were awarded with the GTO badges, while 465 thousand people in 1932, and 835 thousand people in 1933. By the mid-1930-ies, the number of GTO badge-holders had reached 1.2 million people. At the beginning of 1941, the country totaled more than 62 thousand physical training groups (amateur sports teams, including more than 5 million non-professional athletes; and the number of those having passed the ‘1st level GTO’ contest had exceeded 6 million people, as for the ‘2nd level GTO’ requirements, more than 100 thousand people had met them. Millions of Soviet athletes, their coaches and instructors at the physical training institutes completed the Red Army ranks; skier or reconnaissance battalions or guerrilla bands were raised out of these people, they became good snipers or paratroopers. Experience has shown that militarizing mass sports in the 1920-to-1930-ies have not been useless measure, and the defence-applicable purpose of the latter (especially introducing the GTO standards curricula as well.

  16. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study

    OpenAIRE

    Ekouevi, Didier K; Coffie, Patrick A.; Eugene Messou; Adrien Sawadogo; Eholie, Serge P.; Djimon Marcel Zannou; Carin Ahouada; Jocelyn Akakpo; Christelle Ahomadegbé; Jules Bashi; Alice Gougounon-Houéto; Angèle Azon-Kouanou; Fabien Houngbé; Sikiratou Koumakpaï; Florence Alihonou

    2013-01-01

    Background HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). Methods We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART)...

  17. MODELAGEM DO SISTEMA DE AVALIAÇÃO DE CONHECIMENTO, SEGUNDO PARÂMETROS DO ENADE, APLICÁVEL AOS CURSOS SUPERIORES DE GRADUAÇÃO: uma proposta quanto a forma de avaliação nas IES

    OpenAIRE

    CLÉBER AUGUSTO PEREIRA

    2010-01-01

    A proposta de modelagem de sistema de avaliação dos cursos superiores de graduação, segundo os parâmetros exigidos pelo ENADE, emerge da necessidade das IES adequarem sua metodologia e procedimentos de avaliação aos moldes estabelecidos pelo exame. A solução proposta não se dirige a um curso específico de graduação, podendo ser utilizada para qualquer área do conhecimento. O uso de agentes de software em seu desenvolvimento justifica-se em razão de uma aplicação computaciona...

  18. Influencia de un programa de educación sexual en el desarrollo de la conducta sexual en adolescentes del cuarto año de secundaria de la IE Federico Villarreal Túcume 2015.

    OpenAIRE

    Musayón Ursina, Mariela.

    2015-01-01

    Los adolescentes viven en un riesgo social ya que no cuentan con una Educación Sexual progresiva y adecuada a su sexualidad en el aspecto biológico, afectivo, social y espiritual que le permita una conducta sexual equilibrada con el otro sexo y su realización plena como ser humano. El trabajo de Investigación desarrollado es: "la Aplicación de un Programa de Educación Sexual favorece el desarrollo de la Conducta Sexual en Adolescentes del cuarto grado de secundaria de la IE Federico Villarrea...

  19. Rendimiento académico y actividad física en adolescentes. Un estudio en 2º ciclo de la E.S.O. del I.E.S. Pando de Oviedo

    OpenAIRE

    Martín Ocio, Alejandro

    2016-01-01

    Producción Científica El presente estudio tiene como objetivos examinar la relación entre la cantidad de actividad física practicada por el alumnado y su rendimiento académico dentro de las instituciones educativas, teniendo en cuenta el sexo de los participantes. En la investigación participaron 46 estudiantes (56,6% varones) pertenecientes al segundo ciclo de la E.S.O. del I.E.S. Pando ubicado en Oviedo, con edades comprendidas entre 14 y 17 años. Los resultados concluy...

  20. Identificação de Oportunidades de Melhoria em IES Através do Uso Conjunto do Modelo Kano e Matriz de Importância x Desempenho

    OpenAIRE

    Walter, Silvana Anita; Tontini, Gérson; Domingues, Maria José Carvalho de Souza

    2005-01-01

    Este artigo tem como objetivo mostrar resultados parciais de uma pesquisa em andamento que procura utilizar o Modelo Kano de Qualidade Atrativa e Obrigatória e outros métodos de análise na identificação de oportunidades de melhoria em Instituições de Ensino Superior (IES). Para tanto, 20 atributos do curso de administração da Universidade Regional de Blumenau - SC, Brasil, foram analisados através de uma pesquisa quantitativa, com uma amostra de 362 alunos das diferentes habilitações, turnos ...

  1. IE期鼻腔非霍奇金淋巴瘤预后的多因素分析%Multivariate analysis of prognosis of patients with stage IE non-Hodgkin′s lymphomas of the nasal cavity

    Institute of Scientific and Technical Information of China (English)

    胡伟汉; 陈明; 汪惠云; 毛志达; 卢泰祥; 陈茹琴; 骆福添; 孙颖

    2001-01-01

    目的探讨影响IE期鼻腔非霍奇金淋巴瘤患者预后的因素。方法 71例原发于鼻腔非霍奇金淋巴瘤IE期患者,其中37例病灶局限于鼻腔(IE局限组),34例有鼻腔外侵犯(IE超腔组)。44例为单纯放疗,27例为放疗加化疗。生存统计采用Kaplan-Meier法,组间比较采用Log-rank检验。多因素分析采用Cox模型。结果放疗后肿瘤完全消失者5,10年生存率分别为71.9%和59.7%,放疗后残留者均为13.9%(P=0.000 4)。IE局限组5,10年生存率分别为69.8%和56.7%,IE 超腔组分别为40.7%和35.6%,二者差异有显著性(P=0.004 7)。年龄≤44岁患者的预后明显好于年龄>44岁者(P=0.000 3)。IE局限放疗加化疗组和单纯放疗组的10年生存率分别为75.0%和52.0%,IE超腔组则分别为45.0%和37.6%(P=0.064 4)。有无B症状对生存率无显著影响(P=0.792)。Cox多因素分析显示,放疗近期疗效、肿瘤超腔和年龄是影响预后的独立因素。结论鼻腔IE期淋巴瘤的治疗以放疗为主,加上化疗能提高远期生存率。放疗近期疗效、临床分期和年龄对预后有显著影响。%Objective To analyze the factors affecting prognosis of patients with primary non-Hodgkin′s lymphomas (NHL) of the nasal cavity.Methods From Jan. 1968 to Dec. 1997, a total of 71 pateitns wtih stage IE (Ann Arbor staging system, 1971) primary non-Hodgkin′s lymphomas of the nasal cavity were treated in the Tumor Hospital of Sun Yat-sen University of Medical Sciences. In 37 of the 71 patients, the lesions were limited in the nasal cavity (limited IE), and in 34, the lesions were locally extended involving the adjacent structures (extended IE) Forty-four patients were treated with radiotherapy and 27 with radiotherapy plus chemotherapy. Survival analysis was done by the Kaplan-Meier method, and multivariate analysis was carried out using Cox proportional hazard model.Results The 5- and 10-year survival

  2. Design of IED with Integrated Functions of Process Level and Bay Level in Intelligent Substation%智能变电站中过程层和间隔层功能一体化IED的设计

    Institute of Scientific and Technical Information of China (English)

    刘益青; 高厚磊; 魏欣; 李乃永; 向岷江

    2011-01-01

    常规变电站的智能化改造需要增加过程层设备并改造间隔层设备,施工复杂,对中低电压等级间隔经济性欠佳。提出了采用过程层和间隔层功能一体化智能电子设备(IED)的分散安装配置方案,并设计了功能一体化的新型IED,将合并单元、智能终端功能和测控、保护功能在一台物理设备中实现。介绍了该IED的总体设计方案和软硬件结构,主要由PowerPC主处理模块、数字信号处理器(DSP)数据处理模块、现场可编程门阵列(FPGA)综合处理模块和断路器智能控制模块组成。讨论了采样值数据流设计、通用面向对象变电站事件(GOOSE)信息的快速处理方法、测控保护功能设计等问题。最后建立了符合IEC 61850标准的一体化IED的信息模型。功能一体化的新型IED软硬件设计合理,性能满足要求,有较好的经济性,可以有效地简化中低电压等级间隔的智能化改造工作。%The intelligent reconstruction of conventional substation needs to add process level device and to reconstruct bay level device so that causes complicated working and uneconomic for medium and low voltage bay.A distributed configuration scheme of secondary devices using intelligent electronic device(IED) with integrated functions for process level and bay level is presented.Based on the new scheme,a new type of integrated IED is designed,which completely implements merging-unit,intelligent-terminal,measurement-control and protection functions in one physical apparatus.The integrated design scheme and software-hardware architecture of the integrated IED is described,which is composed of four dominating parts: PowerPC main processor modular,digital signal processor(DSP) data processing module,field-programmable gate array(FPGA) integrated processing module and breaker intelligent control module.Several related issues are discussed in detail,including the design of sampled value

  3. Test of a new stable isotopic fingerprinting technique (i.e. Compound Specific Stable Isotope) in an Austrian sub-catchment to establish agricultural soil source contribution to deposited sediment

    Science.gov (United States)

    Mbaye, Modou; Mabit, Lionel; Gibbs, Max; Meusburger, Katrin; Toloza, Arsenio; Resch, Christian; Klik, Andreas; Swales, Andrew; Alewell, Christine

    2017-04-01

    In order to test and refine the use of compound-specific stable isotope (CSSI) as a fingerprinting technique, an innovative study was conducted in a sub-catchment dominated by C3 plants located 60 km north of Vienna. This experimental site consists of 4 different contributing sources (i.e. 3 agricultural fields and one grassed waterway) and one sediment mixture in which the δ13C values of the bulk soil carbon and of various fatty acids (FAs) were analysed after a cost effective sampling strategy. Bi-scatterplots of all possible combinations of δ13C FAs including the bulk soil carbon δ13C showed that bulk soil carbon δ13C is a strong discriminant among the other FAs. Moreover, bulk soil carbon δ13C values highlighted the highest difference between the four sources and the δ13C values of C24 indicated significant differences for all sources while δ13C of C22 did not exhibit a significant difference between the two first sources. An additional correlation analysis revealed that the highest significant linear dependencies are between δ13C16 & δ13C18 > δ13C18 & δ13C24 > δ13C16 & δ13C24. Among the variables, the bulk soil carbon δ13C was found to be the least correlated parameter, confirming that it is the most reliable discriminator to determine the sediment origins in the mixture. To summarize, only the long chain FAs (i.e. C22 and C24) as well as the bulk soil carbon δ13C succeeded in fulfilling our multivariate statistical tests. These findings were confirmed by the mixing polygon tests and Principal Component Analysis. Using three different mixing models (i.e. Iso-source, CSSIAR v1.0 and MIXSIAR), the contribution of the different sources to the mixture were evaluated. All models highlighted that the third source (field having C3 and C4 plants in rotation) and the grassed waterway were the main contributing agricultural area representing 25-31% and 50-57% of the deposited sediment constituting the mixture, respectively.

  4. Modeling of EVCS Power Quality IED Based on IEC61850 Standard%基于IEC61850标准的电动汽车充电站电能质量IED建模

    Institute of Scientific and Technical Information of China (English)

    郭少丰; 吕玉祥; 孙斌; 王金浩

    2014-01-01

    With the development of electric vehicle and the construction and the application of the large-scale Elec-tric Vehicle Charging Station ( EVCS ) , it’s becoming a gradually increasingly significant influence on the power quality of the smart grids for charging station’s heavy loaded charge and discharge. Based on the standard IEC61850,especially facing the methods and features of object-oriented modeling,combined with the technology of power quality monitoring devices of EVCS,this paper analysed the content of the standard IEC61850 applicable to EVCS,proposed new requirements of functional modules of power quality monitoring IED for EVCS,and built a new information model up to the IEC61850 standard. It guaranteed the information transmission of power quality monito-ring IED from EVCS in the smart grid is free,and provided necessary technical support for grasping the influence on the power quality of grids caused by the EVCS.%随着电动汽车的发展和大型电动汽车充电站的建设与应用,充电站大负荷充放电过程对智能电网电能质量的影响日益明显。基于IEC61850标准,特别是面向对象建模的方法与特点,并结合电动汽车充电站电能质量监测装置,分析了IEC61850标准中适用于电动汽车充电站的内容,提出了电动汽车充电站电能质量监测 IED 新的功能要求,建立了符合IEC61850标准的新模型,保证了在智能电网中电动汽车充电站电能质量监测IED信息的自由传输,为掌控电动汽车充电站对电网电能质量的影响提供了必要的技术支持。

  5. Kalninės pušies Pinus mugo Turra porūšių morfologinė ir genetinė įvairovė Kuršių nerijoje

    OpenAIRE

    Vienažindytė, Sandra

    2012-01-01

    Magistro darbe analizuojami Kalninės pušies Pinus mugo Turra Kuršių nerijoje morfologiniai ir genetiniai požymiai, galintys identifikuoti jų porūšius. Tyrimo objektas – Kalninė pušis Pinus mugo Turra, auganti Kuršių nerijos teritorijoje. Šio tyrimo tikslas – įvertinti Pinus mugo porūšių morfologinius požymius Kuršių nerijoje bei nustatyti, šioje teritorijoje labiausiai išplitusio Pinus mugo porūšio nothssp. rotundata Link įvairių morfotipų taksonominę priklausomybę pagal raktinius mor...

  6. Combining Speed and Accuracy in Cognitive Psychology: Is the Inverse Efficiency Score (IES a Better Dependent Variable than the Mean Reaction Time (RT and the Percentage Of Errors (PE?

    Directory of Open Access Journals (Sweden)

    Raymond Bruyer

    2011-02-01

    Full Text Available Experiments in cognitive psychology usually return two dependent variables: the percentage of errors and the reaction time of the correct responses. Townsend and Ashby (1978, 1983 proposed the inverse efficiency score (IES as a way to combine both measures and, hence, to provide a better summary of the findings. In this article we examine the usefulness of IES by applying it to existing datasets. Although IES does give a better summary of the findings in some cases, mostly the variance of the measure is increased to such an extent that it becomes less interesting. Against our initial hopes, we have to conclude that it is not a good idea to limit the statistical analyses to IES without further checking the data.

  7. ICONOGRAFÍA DE LA EVOLUCIÓN BIOLÓGICA EN LOS TEXTOS ESCOLARES DE CIENCIAS NATURALES. (PRESENTES EN LA BIBLIOTECA DE LA I.E.D. JUAN LOZANO Y LOZANO. BOGOTÁ D.C (Pag: 38-50

    Directory of Open Access Journals (Sweden)

    Luis Carlos Javier Ramirez Olaya

    2013-01-01

    Full Text Available Se reconoce la iconografía empleada en 13 libros de ciencias naturales de secundaria, que van desde el año 1983 hasta el 2004. Están distribuidos en seis editoriales, y 11 libros estaban presentes en la biblioteca de la Institución Educativa Distrital* (I.E.D. Juan Lozano y Lozano. El reconocimiento se hizo por medio del análisis de contenido cualitativo, con el fin de identificar las imágenes habituales presentadas a los niños como complemento en la explicación al cambio biológico (en relación al darwinismo y lamarckismo. De esta muestra se analizaron un total de 31 imágenes, donde son frecuentes las jirafas, los pinzones del archipiélago Galápagos y las expresiones fenotípicas de la polilla Biston betularia.

  8. Las TIC en el rendimiento académico en estudiantes del grado quinto de la I.E.D Friedrich Naumann ( Usaquén Bogotá)

    OpenAIRE

    Cubides Vargas, Fernando; Rojas López, Carmen Senovia

    2012-01-01

    El objetivo principal de este proyecto busca establecer si el uso de las TIC facilita y cualifica el rendimiento académico en los estudiantes del grado quinto de la I.E.D. Friedrich Naumann de Usaquén Bogotá; determinar si la calidad en el uso y los tiempos empleados por los estudiantes corresponde a sus resultados académicos e identificar el aporte de las prácticas pedagógicas de los docentes de este grado a través del uso de equipos tecnológicos. También se busca dejar las bases teóricas y ...

  9. Trabalho e estresse: identificação do estresse e dos estressores ocupacionais em trabalhadores de uma unidade administrativa de uma Instituição Pública de Ensino Superior (IES

    Directory of Open Access Journals (Sweden)

    Edward Goulart Junior

    2014-01-01

    Full Text Available The article presents survey of public servants of a Higher Education Institution (HEI that aimed to diagnose the presence of stress in this population, the stress phase in which individuals find themselves and the prevalence of symptoms, whether physical or psychological. This study aimed to characterize the symptomatology of the population experiencing stress and major stressors of the work context where participants act. The survey revealed that 46.6% of the participants are experiencing stress, mostly found in the resistance phase with predominantly psychological symptoms. Among the major stressors of work contexts, stood the physical environment of the workplace, sector infrastructure work, the process of professional performance evaluation adopted by IES, low recognition given to the work done and the small number of servers in certain sectors . The results revealed the presence of stress advancement of this sample and the need for appropriate policy actions and management practices of people who aim to act to minimize this phenomenon.

  10. Rendimiento académico y actividad física en adolescentes : un estudio en 2º ciclo de la E.S.O. del I.E.S. Pando de Oviedo

    OpenAIRE

    Martín Ocio, Alejandro

    2014-01-01

    La investigación que se lleva a cabo en el presente trabajo es un estudio que utiliza como muestra a un grupo de adolescentes del I.E.S. Pando (Oviedo), pertenecientes al 2º ciclo de la E.S.O. Los objetivos de este trabajo son dos: en primer lugar analizar si existe relación entre la actividad física, el rendimiento académico y sexo de los participantes en el mismo y, en segundo lugar, diseñar una línea de intervención en este colectivo utilizando como eje vertebrador la actividad física dent...

  11. Rendimiento académico y actividad física en adolescentes : un estudio en 2º ciclo de la E.S.O. del I.E.S. Pando de Oviedo

    OpenAIRE

    Martín Ocio, Alejandro

    2014-01-01

    La investigación que se lleva a cabo en el presente trabajo es un estudio que utiliza como muestra a un grupo de adolescentes del I.E.S. Pando (Oviedo), pertenecientes al 2º ciclo de la E.S.O. Los objetivos de este trabajo son dos: en primer lugar analizar si existe relación entre la actividad física, el rendimiento académico y sexo de los participantes en el mismo y, en segundo lugar, diseñar una línea de intervención en este colectivo utilizando como eje vertebrador la actividad física dent...

  12. Relevância da estratégia de coopetição para as IES: o posicionamento do Centro Universitário Católico de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Jorge Gaio

    2012-08-01

    Full Text Available The competition from consolidators in the educational market has intensified in the national and regional markets, such as Santa Catarina State, pressing the small and medium size IES to establish strategies of competition, cooperation and coopetition. The purpose of this position paper is to present the structured strategies for service excellence (KANO, 1984 and strategies coopetition (BRANDENBURGER and NALEBUFF, 1996; DAGNINO; PADULA, 2002 used by Centro Universitário Católico de Santa Catarina, established in Joinville since 2009. The literature review covered the main strategies of competition, cooperation, coopetition and the Kano (1984 matrix. It was presented the most relevant strategies under the Kano (1984 model and the coopetition strategies used by Centro Universitário Católico de Santa Catarina. The results of this research indicate the coopetition strategic position between the actors involved in higher education in the region, despite having a different set of strategies in its entrance position.

  13. FORMANDO PROFESSORES PARA UMA ESCOLA INCLUSIVA: OS PROJETOS PEDAGÓGICOS CURRICULARES DOS CURSOS DE LICENCIATURA EM PEDAGOGIA DAS IES PÚBLICAS LOCALIZADAS EM BELÉM-PA EM ANÁLISE

    OpenAIRE

    Nunes, Jessica Ferreira; de Almeida, Glaucia Silva; da Rocha, Genylton Odilon Rego

    2015-01-01

    O tema desde artigo incide sobre o contexto da educação inclusiva, especificamente sobre a formação do Pedagogo. Propomos então, a luz dos ideais do materialismo histórico e dialético, analisar a formação inicial do pedagogo, com base nas Diretrizes Curriculares Nacionais (DCN) e nos Projetos Políticos Curriculares (PPC) dos cursos de pedagogia das Instituições de Ensino Superior (IES) pública de Belém do Pará. O problema discutido ao longo deste artigo é o da relação entre a formação inicial...

  14. Nanoparticles and self-organisation: the emergence of hierarchical properties from the nanoparticle soup (i.e., the small is getting bigger). Concluding remarks for Faraday Discussion: Nanoparticle Synthesis and Assembly.

    Science.gov (United States)

    Schiffrin, David J

    2015-01-01

    Some four years ago, one of the participants in this Discussion (Prof. Nicholas Kotov) predicted that: "within five years we shall see multiple examples of electronic, sensor, optical and other devices utilizing self-assembled superstructures" (N. A. Kotov, J. Mater. Chem., 2011, 21, 16673-16674). Although this prediction came partially to fruition, we have witnessed an unprecedented interest in the properties of materials at the nanoscale. The point highlighted by Kotov, however, was the importance of self-assembly of structures from well characterised building blocks to yield hierarchical structures, hopefully with predictable properties, a concept that is an everyday pursuit of synthetic chemists. This Discussion has brought together researchers from a wide range of disciplines, i.e., colloid science, modelling, nanoparticle synthesis and organisation, magnetic and optical materials, and new imaging methods, within the excellent traditional Faraday Discussion format, to discuss advances in areas relevant to the main theme of the meeting.

  15. Design of MobiIe Robot ControI System Based on Wi-Fi%基于Wi-Fi的智能移动机器人控制系统设计

    Institute of Scientific and Technical Information of China (English)

    卞秀辉

    2016-01-01

    The paper presents the design of mobiIe robot based on the Wi-Fi.On the design,the sIave use STC microcon-troI er as the core controI er,four-way tracing for bIack or white Iines can be changed automaticaI y.Avoiding obstacIes used the fixed frequency detection part of infrared ray transmitting and receiving,impIements the detecting of not afraid of the natu-raI Iight,using uItrasonic sensors for distance measurement,four-wheeI drive makes the car movement more smoothIy.%提出了基于Wi-Fi的智能移动机器人的设计实施方案。该设计中下位机选用STC单片机为核心控制器,四路寻迹对于寻黑线或白线可自行调节,避障检测部分利用了固定频率红外光的发射与接收来完成,实现了不怕光避障,利用超声波传感器实现距离测量,四轮驱动使得小车运动更流畅。下位机通过Wi-Fi技术实现与上位机的通信,整个系统结构简单,控制灵活。

  16. Institutional participative strategic planning method for community higher education institution (HEI Planejamento estratégico participativo em uma instituição de ensino superior (IES comunitária

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius Anátocles Ferreira

    2010-10-01

    Full Text Available This article proposes a method for the participation of university managers and stakeholders in the validation of the questions and strategy choice during the Strategic Planning process in a Community HEI. It proposes a tool for participations that considers an evolutionary and systemic vision in the proposition. It preserves the HEI community characteristics. The use of interviews, meetings, seminars and works with the community members envolved through working g roups and committees, is a way to legitimate the results and to achieve a integrated strategic planning.Este artigo propõe uma metodologia de participação da comunidade de gestores universitários e stakeholders para validação das questões e determinação das estratégias no processo de Planejamento Estratégico em IES comunitária. Propõe ainda um mecanismo de participação que considera uma visão sistêmica e evolutiva na proposição, estruturação e no processo de operacionalização do planejamento estratégico, preservando as características das comunidades das IES. A utilização de entrevistas, reuniões, seminários e trabalhos com membros das comunidades envolvidas através de grupos de trabalho e comitês, servem como forma de legitimação dos resultados e para realizar um pensamento estratégico integrado.

  17. La experiencia en el programa de adaptación curricular en grupo en el IES "Matilde Salvador" de Castellón de la Plana durante los cursos 99/00 y 00/01 = Experience with the "Programa de adaptación curricular en grupo" at the IES "Matilde Salvador" in Castellon de la Plana, during the years 99/00 and 00/01

    OpenAIRE

    Sidro, José Juan

    2002-01-01

    El desarrollo de la LOGSE (1990) en el campo de la atención a la diversidad en los Institutos de Educación Secundaria (IES) tiene como marco de referencia en la Comunidad Valenciana la Orden de Atención a la Diversidad de 29 de junio de 1999. En ella se establece el Plan de Actuación para la atención a la diversidad del alumnado con medidas de carácter general junto a medidas específicas. En este artículo pretendemos hacer un análisis y valoración detallada de lo que ha supuesto poner en marc...

  18. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study

    Science.gov (United States)

    Ekouevi, Didier K.; Balestre, Eric; Coffie, Patrick A.; Minta, Daouda; Messou, Eugene; Sawadogo, Adrien; Minga, Albert; Sow, Papa Salif; Bissagnene, Emmanuel; Eholie, Serge P.; Gottlieb, Geoffrey S.; Dabis, François; Zannou, Djimon Marcel; Ahouada, Carin; Akakpo, Jocelyn; Ahomadegbé, Christelle; Bashi, Jules; Gougounon-Houéto, Alice; Azon-Kouanou, Angèle; Houngbé, Fabien; Koumakpaï, Sikiratou; Alihonou, Florence; d’Almeida, Marcelline; Hodonou, Irvine; Hounhoui, Ghislaine; Sagbo, Gracien; Tossa-Bagnan, Leïla; Adjide, Herman; Drabo, Joseph; Bognounou, René; Dienderé, Arnaud; Traore, Eliezer; Zoungrana, Lassane; Zerbo, Béatrice; Sawadogo, Adrien Bruno; Zoungrana, Jacques; Héma, Arsène; Soré, Ibrahim; Bado, Guillaume; Tapsoba, Achille; Yé, Diarra; Kouéta, Fla; Ouedraogo, Sylvie; Ouédraogo, Rasmata; Hiembo, William; Gansonré, Mady; Messou, Eugène; Gnokoro, Joachim Charles; Koné, Mamadou; Kouakou, Guillaume Martial; Bosse, Clarisse Amani; Brou, Kouakou; Assi, Achi Isidore; Chenal, Henri; Hawerlander, Denise; Soppi, Franck; Minga, Albert; Abo, Yao; Bomisso, Germain; Eholié, Serge Paul; Amego, Mensah Deborah Noelly; Andavi, Viviane; Diallo, Zelica; Ello, Frédéric; Tanon, Aristophane Koffi; Koule, Serge Olivier; Anzan, Koffi Charles; Guehi, Calixte; Aka, Edmond Addi; Issouf, Koffi Ladji; Kouakou, Jean-Claude; N’Gbeche, Marie-Sylvie; Touré, Pety; Avit-Edi, Divine; Kouakou, Kouadio; Moh, Magloire; Yao, Valérie Andoblé; Folquet, Madeleine Amorissani; Dainguy, Marie-Evelyne; Kouakou, Cyrille; Méa-Assande, Véronique Tanoh; Oka-Berete, Gladys; Zobo, Nathalie; Acquah, Patrick; Kokora, Marie-Berthe; Eboua, Tanoh François; Timité-Konan, Marguerite; Ahoussou, Lucrèce Diecket; Assouan, Julie Kebé; Sami, Mabéa Flora; Kouadio, Clémence; Renner, Lorna; Goka, Bamenla; Welbeck, Jennifer; Sackey, Adziri; Owiafe, Seth Ntiri; Wejse, Christian; Silva, Zacarias José Da; Paulo, Joao; Rodrigues, Amabelia; da Silva, David; Medina, Candida; Oliviera-Souto, Ines; Østergaard, Lars; Laursen, Alex; Sodemann, Morten; Aaby, Peter; Fomsgaard, Anders; Erikstrup, Christian; Eugen-Olsen, Jesper; Maïga, Moussa Y; Diakité, Fatoumata Fofana; Kalle, Abdoulaye; Katile, Drissa; Traore, Hamar Alassane; Minta, Daouda; Cissé, Tidiani; Dembelé, Mamadou; Doumbia, Mohammed; Fomba, Mahamadou; Kaya, Assétou Soukho; Traoré, Abdoulaye M; Traoré, Hamady; Toure, Amadou Abathina; Dicko, Fatoumata; Sylla, Mariam; Berthé, Alima; Traoré, Hadizatou Coulibaly; Koïta, Anta; Koné, Niaboula; N'Diaye, Clémentine; Coulibaly, Safiatou Touré; Traoré, Mamadou; Traoré, Naïchata; Charurat, Man; Ajayi, Samuel; Dapiap, Stephen; Otu; Igbinoba, Festus; Benson, Okwara; Adebamowo, Clément; James, Jesse; Obaseki; Osakede, Philip; Olasode, John; Sow, Papa Salif; Diop, Bernard; Manga, Noël Magloire; Tine, Judicael Malick; Signate Sy, Haby; Ba, Abou; Diagne, Aida; Dior, Hélène; Faye, Malick; Gueye, Ramatoulaye Diagne; Mbaye, Aminata Diack; Patassi, Akessiwe; Kotosso, Awèrou; Kariyare, Benjamin Goilibe; Gbadamassi, Gafarou; Komi, Agbo; Mensah-Zukong, Kankoé Edem; Pakpame, Pinuwe; Lawson-Evi, Annette Koko; Atakouma, Yawo; Takassi, Elom; Djeha, Améyo; Ephoévi-gah, Ayoko; Djibril, Sherifa El-Hadj; Dabis, François; Bissagnene, Emmanuel; Arrivé, Elise; Coffie, Patrick; Ekouevi, Didier; Jaquet, Antoine; Leroy, Valériane; Lewden, Charlotte; Sasco, Annie; Azani, Jean-Claude; Allou, Gérard; Balestre, Eric; Bohossou, Franck; Karcher, Sophie; Gonsan, Jules Mahan; Carrou, Jérôme Le; Lenaud, Séverin; Nchot, Célestin; Malateste, Karen; Yao, Amon Roseamonde; Siloué, Bertine; Clouet, Gwenaelle; Djetouan, Hugues; Doring, Alexandra; Kouakou, Adrienne; Rabourdin, Elodie; Rivenc, Jean; Anglaret, Xavier; Ba, Boubacar; Essanin, Jean Bosco; Ciaranello, Andrea; Datté, Sébastien; Desmonde, Sophie; Diby, Jean-Serge Elvis; Gottlieb, Geoffrey S.; Horo, Apollinaire Gninlgninrin; Kangah, Serge N'zoré; Malvy, Denis; Meless, David; Mounkaila-Harouna, Aida; Ndondoki, Camille; Shiboski, Caroline; Thiébaut, Rodolphe; PAC-CI; Abidjan

    2013-01-01

    Background HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). Methods We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d’Ivoire, Mali, and Senegal, in the West Africa region. Results Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3–51.7) and 42.4 years, IQR (37.0–47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm3, IQR (83–247) among HIV-2 infected patients and 146 cells/mm3, IQR (55–249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm3 after 24 months on ART for HIV-2 patients and 169 cells/mm3 for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7–4.3). Conclusions This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population. PMID:23824279

  19. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

    Directory of Open Access Journals (Sweden)

    Didier K Ekouevi

    Full Text Available HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA.We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region.Data was merged for 1,754 patients (56% female, including 1,021 HIV-2 infected patients (551 on ART and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART. At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7 and 42.4 years, IQR (37.0-47.3 for dually seropositive patients (p = 0.048. Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C. The median CD4 count at the ART initiation is 166 cells/mm(3, IQR (83-247 among HIV-2 infected patients and 146 cells/mm(3, IQR (55-249 among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3 after 24 months on ART for HIV-2 patients and 169 cells/mm(3 for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3.This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.

  20. ACTIONS TAKEN BY THE LOCAL AUTHORITIES OF THE KUBAN AND STAVROPOL REGIONS FOR DEVELOPING PRODUCTION OF CHEMICAL AGENTS FOR FARMING, OVER THE PERIOD FROM 1966 TO THE 1980-ies

    Directory of Open Access Journals (Sweden)

    Olga Ivanovna Alekseenko

    2015-01-01

    Full Text Available The paper considered the actions taken by the local authorities of the Kuban and Stavropol Regions for developing production of chemical agents for farming over the period from 1966 to the-1980-ies. The author examined the measures undertaken by both the central authority and local power bodies, for construction of enterprises for the chemical industry, to expand the output of mineral fertilizers. The paper examined the practices of industrial operation of the Nevinnomyssk chemical complex, the Krasnodar chemical plant, the complex of vitamin and biochemical reagents named after K. Marx, and the chemical plant located in the Кropotkin town. The review has pointed out that these enterprises have taken an appreciable part in supplying the farming sector with the high-quality chemical agents. The author has drawn a conclusion that owing to various patterns and techniques the CPSU and State bodies applied in raising labour and social activity in workers involved into the chemical production, the significant growth in production of mineral fertilizers has been achieved.

  1. ACTITUDES PRO AMBIENTALES EN LOS NIÑOS Y NIÑAS DE SEXTO GRADO. UN APORTE A LA EDUCACIÓN AMBIENTAL EN EL COLEGIO KIMY PERNIA DOMICÓ IED – JM

    Directory of Open Access Journals (Sweden)

    Carlos Humberto Barreto Tovar

    2015-12-01

    Full Text Available Este escrito recoge los resultados de la investigación desarrollada en el año 2014 con los estudiantes del curso 603 del IED Kimy Pernía Domicó Jornada Mañana, con el propósito de reconocer y analizar sus actitudes proambientales. El abordaje desde el punto de vista metodológico, se encuadra en la Investigación Acción Educativa; esto con el desarrollo de una etapa inicial de diagnóstico y el desarrollo posterior de tres estrategias para el reconocimiento y análisis  respectivo del componente cognoscitivo, afectivo y connativo de las actitudes proambientales de los niños y las niñas participantes del proceso. La evaluación de la implementación del programa de actividades resultó positiva, en tanto se  reconocen y analizan las actitudes proambientales en los niños y niñas participantes como punto de partida para  el fortalecimiento de sus actitudes y comportamientos frente al ambiente. A la par, las maestras involucradas en el proceso fortalecen sus propias actitudes proambientales y cambian su mirada sobre los estudiantes, el contexto y las propias dinámicas del aula.

  2. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients.

    Science.gov (United States)

    Wang, Liang; Xia, Zhong-jun; Huang, Hui-qiang; Lu, Yue; Zhang, Yu-jing

    2012-11-01

    We conducted a retrospective study of 135 patients of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL) treated with CHOP as induction chemotherapy to find some valuable prognostic factors and analyze the usefulness of International Prognostic Index (IPI) and Korean Prognostic Index (KPI) in predicting prognosis. Most of the patients were in the low-risk group (IPI score 0-1). Complete remission (CR) after induction chemotherapy was achieved in 31.8 % of the patients, which increased to 69.6 % after radiotherapy. The 2-, 5-, and 10-year overall survival (OS) rates were 60, 48, and 43 %, respectively. Patients with better performance status (ECOG 0-1), normal serum LDH level, without local invasiveness, low KPI scores, and IPI score of 0 had significantly better overall survival (P KPI score systems should be improved further to classify patients into different groups, and should be validated in larger prospective trials. Due to the multi-drug resistance mechanism of ENKTL, CHOP is no longer the state of art and novel drugs should be incorporated into future treatments.

  3. 微声聚能穿孔装置优化设计及IED安全销毁实验%Optimization design of micro-acoustic shaped charge device and research on its safe destruction of IED

    Institute of Scientific and Technical Information of China (English)

    徐全军; 白帆; 李裕春; 龚自正; 张庆明

    2012-01-01

    Based on the Held initiation theory, and the fact that shaped charge jet against the charge can produce low velocity explosion, this paper presents a new design of micro-acoustic shaped charge device. The orthogonal analysis methods were applied to optimize the charge structure. The experiments indicate that the noise elimination ability and the anti-detonation ability of the device are fine. The simulator charge boxes were destroyed with low velocity detonation, which helps reduce the explosive harm and allows for destroying IED safely.%根据Held引爆理论,利用聚能射流使炸药只燃烧或发生不完全爆轰的特点,设计了微声聚能穿孔装置,并对装药结构进行了正交优化.实验结果表明,装置的消声能力良好,用于销毁模拟爆炸药盒时,装药仅发生低速爆轰,达到了安全销毁简易爆炸装置的目的.

  4. Quantifying the density-quality of photogrammetrically created point-clouds of linear architectural/urban elements as a function of shooting distances and number of camera positions I.E. shooting-directions

    Directory of Open Access Journals (Sweden)

    Đorđević Đorđe

    2015-01-01

    Full Text Available This paper examines the impact of various object-to-camera distances and the number of station-points i.e. various shooting directions with regard to the obtained Density-quality of photogrammetrically created Point-clouds - as digital representations of the existent linear architectural/urban objects/elements. According to an artificial (purified experimental scene used, the conclusion is that with the chosen focal lengths/object-to-camera distances, with shooting directions perpendicular to the axis of that object, with station-points uniformly radially distributed around it (at a circle of 360deg, and with the obtained values of photogrammetric-software process-quality outputs which belong to the recommended ranges, the achieved density-level of the created Point-clouds may be treated as independent on the camera's radial-movement angle but dependent on the percentage of „Object's Photo-Coverage”: the lower the Coverage, the lower the density. Also, regardless of the Coverage level, the majority of the generated points are generally more "densimetrically" precise than they are "densimetrically" accurate.

  5. LA UNIDAD DIDÁCTICA ORIENTADA A LA COMPRENSION DE LA IRRITABILIDAD COMO PATRON COMUN A TODOS LOS ORGANISMOS PARA FORTALECER LAS RELACIONES COOPERATIVAS EN LOS ESTUDIANTES DEL GRADO 902 DEL IED COLEGIO KIMY PERNIA DOMICO

    Directory of Open Access Journals (Sweden)

    Dennys Eliana Rodríguez Chiguasuque

    2015-12-01

    Full Text Available Se presenta la propuesta del diseño de una unidad didáctica que se realizó en el eje dinámica y mantenimiento de los sistemas de la Licenciatura en Biología de la Universidad Pedagógica Nacional, en donde se plantea el diseño de una unidad didáctica orientada a la comprensión de la irritabilidad como patrón común a todos los organismos, permitiendo fortalecer las relaciones cooperativas en los estudiantes del grado 902 del IED Colegio Kimy Pernía Domicó, ubicado en el barrio Bosa de la ciudad de Bogotá. En la cual, además del contenido temático, contemplara también un enfoque humanístico, crítico y reflexivo que les permitiera no solo el aprendizaje del patrón, sino la aplicabilidad del mismo en contexto; tomando la “educación problematizadora”. Por último se puede evidenciar que la unidad didáctica es de gran importancia para el proceso de enseñanza aprendizaje, además de ello le permite al maestro obtener habilidades en la planeación y planteamiento de actividades, lo que es de gran aporte para su formación profesional.

  6. 基于经验模态分解样本熵的肌电信号识别%EMG SignaI Recognition Based on EMD SampIe Entropy

    Institute of Scientific and Technical Information of China (English)

    席旭刚; 朱海港; 罗志增; 张启忠

    2014-01-01

    AccOrding tO the chaOtic and nOnIinear characteristics Of surface eIectrOmyOgraphy( sEMG ),a fast and efficient hands mOvement sEMG pattern recOgnitiOn methOd fOr reaI-time cOntrOI Of myOeIectric prOsthetic hand is designed. A muIti-mOdeIing pattern recOgnitiOn methOd Of sEMG features based On the empiricaI mOde decOmpOsitiOn( EMD ) sampIe entrOpy and cIustering anaIysis is prOpOsed. First,it decOmpOses the sEMG signaI intO a set Of intrinsic mOde functiOns ( IMF),then cOmbines sOme Of the IMF which cOntains the usefuI infOrmatiOn accOrding tO frequency effectiveness,and caIcuIates the sampIe entrOpy Of the cOmbinatiOn. The sampIe entrOpy Of twO sEMG Of the extensOr carpi uInaris and fIexOr carpi uInaris cOnstitute the feature vectOr,the cIustering cIassifier which based On principaI axis cIustering arithmetic is appIied tO cIassify the fOur hand mOvements. The resuIt shOws that fOur mOvements( hand extensiOn,hand grasps,wrist spreads and wrist bends ) are successfuIIy identified. The average recOgnitiOn rate is 93%. The methOd achieved high recOgnitiOn rate,anti-interference abiIity and Iess cOmputatiOn,that is suitabIe fOr the cOntrOI Of the myOeIectric prOsthetic hand.%针对表面肌电信号非线性、噪声强等特点,设计一种快速有效的表面肌电信号手部多运动模式识别方法,用于肌电假手的实时控制。提出了一种基于经验模态分解样本熵和聚类分析的表面肌电信号多运动模式识别方法。该方法对动作持续阶段的信号首先进行经验模态分解,将其分解为多个平稳的固有模态函数( IMF),再依据频率有效度选取若干个包含肌电信号有效信息的IMF分量求和后,计算其样本熵。以尺侧腕伸肌和尺侧腕屈肌两路肌电信号对应的EMD样本熵作为特征向量,设计了主轴核聚类算法的聚类分类器进行模式识别。成功识别了展拳、握拳、腕上翻和腕下翻4种动作,平均识别率达到93%。该方法取

  7. Validação de um instrumento para medir o clima organizacional entre alunos de programas de pós-graduação de uma IES

    Directory of Open Access Journals (Sweden)

    Moro, Angélica Balconi

    2015-05-01

    Full Text Available This article presents results of a research that aimed to adapt and validate a set of components and their respective indicators in order to compose the categories of analysis of organizational atmosphere for students of Postgraduate Programs (PPG of a Higher Education Institution (IES. The sample was composed of 200 students from four PPGs. To develop this study, a questionnaire consisting of two parts was used: one consisting of seven questions relating to identification data, and the other about the organizational atmosphere that was built on the methodology of Luz (2003 and Rizzatti (2002 and adapted to the reality of PPGs in question. The questionnaire was evaluated regarding its suitability and it was submitted to semantic and content validation. After the survey data, descriptive analysis, factor analysis, varimax rotation with standardization and reliability calculations were performed. Communalities that met the minimum acceptable value of 0.4 were evaluated. Thus, with the analysis and restructuring of the components and indicators, a model for analyzing organizational atmosphere for students of PPGs was validated. The result of this research will serve as a source of information for managers to develop processes that aim to improve the organizational atmosphere, contributing to a higher performance of PPGs. O artigo apresenta resultados da pesquisa que teve por objetivo adaptar e validar um conjunto de componentes e seus respectivos indicadores com a finalidade de compor as categorias de análise do clima organizacional para alunos de Programas de Pós-Graduação (PPG de uma Instituição de Ensino Superior (IES. Participaram da amostra, 200 alunos de quatro PPGs de uma Instituição Pública de Ensino Superior. Para o desenvolvimento deste estudo, foi utilizado um questionário composto por duas partes: uma com sete questões referentes aos dados de identificação, e outra referente ao clima organizacional que foi construída com

  8. SPECIFICUL ACTIVITĂŢII SPECIALE DE INVESTIGAŢIE ŞI ACŢIUNII DE URMĂRIRE PENALĂ ÎNTREPRINSE PENTRU ADMINISTRAREA PROBELOR LA CERCETAREA CRIMELOR CIBERNETICE

    Directory of Open Access Journals (Sweden)

    Svetlana PURICI

    2016-03-01

    Full Text Available Importanţa investigării „criminalităţii informatice” este dictată nu doar de progresul tehnic, dar în special de prezenta bază normativă în reglementările internaţionale şi în legile naţionale ale Republicii Moldova, precum: Legea cu privire la informatică, Legea privind accesul la informaţie etc., reguli ce trebuie aplicate şi care se vor reflecta în viaţa noastră, în special în procesul de apărare a drepturilor în judecată – moment în care importanţa şi influenţa „investigării crimina­lităţii cibernetice” este remarcată în procesul penal. Forma electronică a remiterii informaţiilor favorizează posibilitatea interceptării la distanţă a informaţiilor fără un oarecare transfer vizual al obiectelor materiale. Între activitatea specială de investigaţie în cadrul investigării crimelor cibernetice şi procesul penal există o legătură reciprocă, menirea primei fiind contribuţia nemijlocită la buna desfăşurare a procesului penal, prin cercetarea obiectivă, imparţială şi multilaterală a faptelor pasibile de pedeapsă penală, astfel asigurându-se aplicarea echitabilă a justiţiei. THE SPECIFICITY OF SPECIAL INVESTIGATIVE ACTIVITIES AND PROSECUTION ACTIONS TAKEN FOR THE ADMINISTRATION OF EVIDENCE ON RESEARCH OF CYBERCRIMESThe interest of the “cybercrime investigations” is given not only by the results of the technical progress, but especially by the existent, normative ground in the internaţional and especially national laws in Republic of Moldova, such as: The Law on informatics, The Law on access to information etc., rules that have to be applied and that will have effect on our life, in particular in the stage of defending the rights in the judicial way – the moment where the importance and the influence of “cybercrime investigations” in the penal procedural law is remarked. Electronic form of the information submission promotes distinctly to a possibility of distant

  9. Moda De Alta Geometría”. Una Estrategia para desarrollar competencias científicas en los estudiantes del Colegio Marruecos y Molinos IED J.T. De Bogotá D.C

    Directory of Open Access Journals (Sweden)

    Mónica Andrea López Sarmiento

    2015-12-01

    Full Text Available Este trabajo es el resultado de la implementación del ambiente de aprendizaje “Moda de Alta Geometría”, ejecutado por estudiantes y maestros de grado Noveno jornada tarde, desde el evento mundialista, Brasil 2014, donde se vinculan las áreas de lengua castellana, ciencias sociales, tecnología, educación física, ciencias naturales,  educación ambiental y matemáticas, en el  colegio Marruecos y Molinos IED, localidad 18 Rafael Uribe Uribe, en la ciudad de Bogotá. El ambiente se llevó a cabo  en tres fases: diseño, implementación y socialización. Con el objetivo de desarrollar competencias científicas mediante la observación, exploración, análisis de información, y generación de estrategias para dar solución a diferentes problemáticas a partir de la construcción y presentación de un traje de fantasía a escala real, representativo de cada país participante en el evento deportivo, elaborado en las técnicas de origami. Este ambiente favoreció el trabajo colaborativo entre los estudiantes, así como el replanteamiento de las prácticas pedagógicas de los docentes vinculados al proyecto y la participación de diferentes estamentos de la comunidad educativa, como las familias, quienes estuvieron activos en el desarrollo del mismo

  10. 12-month mortality and loss-to-program in antiretroviral-treated children: The IeDEA pediatric West African Database to evaluate AIDS (pWADA, 2000-2008

    Directory of Open Access Journals (Sweden)

    Peterson Kevin

    2011-06-01

    Full Text Available Abstract Background The IeDEA West Africa Pediatric Working Group (pWADA was established in January 2007 to study the care and treatment of HIV-infected children in this region. We describe here the characteristics at antiretroviral treatment (ART initiation and study the 12-month mortality and loss-to-program of HIV-infected children followed in ART programs in West Africa. Methods Standardized data from HIV-infected children followed-up in ART programs were included. Nine clinical centers from six countries contributed to the dataset (Benin, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal. Inclusion criteria were the followings: age 0-15 years and initiated triple antiretroviral drug regimens. Baseline time was the date of ART initiation. WHO criteria was used to define severe immunosuppression based on CD4 count by age or CD4 percent 6 months after ART initiation and factors associated with these two outcomes. Results Between June 2000 and December 2007, 2170 children were included. Characteristics at ART initiation were the following: median age of 5 years (Interquartile range (IQR: 2-9 and median CD4 percentage of 13% (IQR: 7-19. The most frequent drug regimen consisted of two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitors (62%. During the first 12 months, 169 (7.8% children died and 461(21.2% were lost-to-program. Overall, in HIV-infected children on ART, the 12-month probability of death was 8.3% (95% Confidence Interval (CI: 7.2-9.6%, and of loss-to-program was 23.1% (95% CI: 21.3-25.0%. Both mortality and loss-to program were associated with advanced clinical stage, CD4 percentage 2005 of ART initiation. Conclusion Innovative and sustainable approaches are needed to better document causes of death and increase retention in HIV pediatric clinics in West Africa.

  11. PARTICULARITĂŢILE STRUCTURII MORFOLOGICE ÎN PRIMII DOI ANI DE VEGETAŢIE A SPECIEI DE ECHINACEA PURPUREA (L. ÎN CONDIŢII BIOECOLOGICE ALE REPUBLICII MOLDOVA

    Directory of Open Access Journals (Sweden)

    Victor MELNIC

    2016-02-01

    Full Text Available A fost studiată structura morfologică a speciei de Echinacea purpurea cultivată timp de doi ani în condiţii bioecolo­gice autohtone. Ulterior, analizând acumularea biomasei diferitelor părţi de plantă în diferite faze de vegetaţie. Rezulta­tele obţinute au arătat că dinamica acumulării de biomasă la toate trei părţi ale plantei are o capacitate sporită în ce pri­veşte masa şi numărul de lăstari, inflorescenţe, atât în primul an de cultură, cât şi în al doilea an. Acest fapt este o dovadă a adaptabilităţii sporite la condiţiile bioecologice autohtone.THE PECULIARITIES OF THE MORPHOLOGICAL STRUCTURE IN THE FIRST TWO YEARSOF VEGETATION OF THE SPECIES ECHINACEA PURPUREA (L. INMOLDOVA'S BIOECOLOGICAL CONDITIONSIn this paper are the results of studying of the morphological structure of Echinacea purpurea species cultivated for two years in indigenous bioecological conditions. In this period of time was analyzed biomass accumulation of different plant parts in different stages of vegetation. The results showed that the dynamics of biomass accumulation in all three parts of the plant has increased capacity as well as the number of flowering shoots, both in the first year of cultivation and in year two. This proves about an increased adaptability to indigenous bioecological conditions. 

  12. Effect of Age at Antiretroviral Therapy Initiation on Catch-Up Growth within the First 24 Months among HIV-Infected Children in the IeDEA West African Pediatric Cohort

    Science.gov (United States)

    Jesson, Julie; Koumakpaï, Sikiratou; Diagne, Ndeye R.; Amorissani-Folquet, Madeleine; Kouéta, Fla; Aka, Addi; Lawson-Evi, Koko; Dicko, Fatoumata; Kouakou, Kouadio; Pety, Touré; Renner, Lorna; Eboua, Tanoh; Coffie, Patrick A.; Desmonde, Sophie; Leroy, Valériane

    2015-01-01

    Background We described malnutrition and the effect of age at antiretroviral therapy (ART) initiation on catch-up growth over 24 months among HIV-infected children enrolled in the IeDEA West African paediatric cohort (pWADA). Methods Malnutrition was defined at ART initiation (baseline) by a Z-score <-2 SD, according to three anthropometric indicators: Weight-for-age (WAZ) for underweight, Height-for-age (HAZ) for stunting, and Weight-for-Height/BMI-for-age (WHZ/BAZ) for wasting. Kaplan-Meier estimates for catch-up growth (Z-score ≥-2 SD) on ART, adjusted for gender, immunodeficiency and malnutrition at ART initiation, ART regimen, time period and country, were compared by age at ART initiation. Cox proportional hazards regression models determined predictors of catch-up growth on ART over 24 months. Results Between 2001 and 2012, 2004 HIV-infected children < 10 years of age were included. At ART initiation, 51% were underweight, 48% were stunted and 33% were wasted. The 24-month adjusted estimates for catch-up growth were 69% (95% confidence interval [CI]: 57;80), 61% (95%CI: 47;70), and 90% (95%CI: 76;95) for WAZ, HAZ, and WHZ/BAZ, respectively. Adjusted catch-up growth was more likely for children <5 years of age at ART initiation compared to children ≥5 years for WAZ, HAZ (P<0.001), and for WHZ/BAZ (P = 0.026). Conclusions Malnutrition among these children is an additional burden that has to be urgently managed. Despite a significant growth improvement after 24 months on ART, especially in children <5 years, a substantial proportion of children still never achieved catch-up growth. Nutritional care should be part of the global healthcare of HIV-infected children in sub-Saharan Africa. PMID:25955835

  13. Conhecimento e formação nas IES periféricas perfil do aluno "novo" da educação superior Knwoledge and education in the peripheral higher education institutions: profile of the "new" undergraduate student

    Directory of Open Access Journals (Sweden)

    Luiz Percival Leme Britto

    2008-11-01

    Full Text Available Considerando a forma como se organiza atualmente a Educação Superior no Brasil, num contexto de forte demanda por conhecimento de caráter instrumental e normativo, voltado para a adequação dos sujeitos, de suas condutas e avaliações às exigências da produção e do consumo urbanos, busca-se avançar o reconhecimento das concepções de conhecimento e de desenvolvimento pessoal do estudante universitário. Para tanto, apresentamos neste trabalho uma análise do campo da Educação Superior no Brasil atual, com ênfase na identificação caracterização de IES periférica e do aluno "novo". Este trabalho apresenta resultados parciais de pesquisa que vem sendo realizadas em torno do tema "Educação superior, cultura escrita e conhecimento".Considering the way in which Higher Education is presently structured in Brazil, in a context characterized by strong demands for normative and instrumental knowledge, aiming to adjust the conducts and evaluations of the subjects to the demands of the market-place, this study seeks the advance of the analysis of the concepts of knowledge and personal development of the university student. We present in this paper an analysis of Higher Education in Brazil, emphasizing the characterization and identification of the peripheral Higher Education Institutions and the "new" student. This work presents partial results of a research that is being done on the theme "Higher Education, Literacy and knowledge".

  14. 基于BP神经网络对七里街测站洪峰的预报与分析%The analysis and forecast of flood crest in Qilij ie Station based on the BP neural network

    Institute of Scientific and Technical Information of China (English)

    肖恭伟; 刘国林; 曹淑敏; 孙志阳

    2016-01-01

    According to the recursion in different section of time,and the monitoring data of wa-ter level in three hydrological sites including the east reach of Jianxi,Shuiji,and Jianyang,we find that the optimal node number of hidden layer of BP neural network is 10 through complex calculation,and establish a mathematical model to forecast the water level in Qilij ie Station using the BP neural network.On this basis,we can amend the forecast results with recursion in differ-ent section of time.The caculation results show that this method improves the forecast accuracy. It can be pointed out through calculation that the correction method of recursion in different sec-tion of time is a better choice due to the coincidence between results and facts.%在分析预报误差的时间分段递推修正方法的基础上,以建溪流域东游、水吉、建阳三个水文站点的水位监测数据为基础,计算得到BP神经网络隐含层最优节点数目为10,建立了 BP 神经网络对七里街测站水位预报的数学模型。在此基础上,利用时间分段递推修正方法对预报的结果进行修正,计算结果表明,时间分段递推修正方法使得预报精度提高很多,其结果与实际更加符合。

  15. Research on QR Code Methods of VehicIe Lookup and Position for Indoor Parking%基于QR Code的室内寻车定位方法研究

    Institute of Scientific and Technical Information of China (English)

    赵炎; 蓝箭; 李印; 李新雨

    2015-01-01

    随着城市化的发展,室内停车场建设的规模化、复杂化带来了寻车难的问题。然而,由于室内环境的特殊性和高精度定位要求,传统的依靠卫星和基站进行定位的方法已经无法实现室内车位的精准定位。因此,提出了一种利用Android手机的扫码定位方法,将QR Code(Quick Response Code)编解码算法[1-3]与SQLite轻量数据库相结合。手机扫码后,从数据库中查询出车位的像素点信息,将其标记在手机端2D地图中。从而实现了车位的精准定位和引导,为室内寻车定位提出了一种快速高效的实现方法。%A scanning code tag-based positioning method on Android smart-phone is proposed in this paper.It com-bines SQLite database and the QR Code (Quick Response Code) aIgorithm[1-3],the QR Code functions as smart IabeIs to store parking information,mobiIe phone acquires the pixeI information by querying the database after scanning QR Code,and dis-pIays the corresponding coordinates in 2D map,enabIing precise positioning and navigation of parking spaces.It provides a quick and effective positioning soIution for the indoor parking Iots.

  16. PERFIL DOS DISCENTES (INGRESSANTES E CONCLUINTES DE SECRETARIADO EXECUTIVO: UM ESTUDO COMPARATIVO NAS INSTITUIÇÕES DE ENSINO SUPERIOR (IES PÚBLICAS EXECUTIVE SECRETARIAT STUDENTS´ PROFILE (FRESHMEN AND SENIORS: A COMPARATIVE STYDY IN PUBLIC EDUCATION INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Vania Souza Bilert

    2012-05-01

    Full Text Available

    O objetivo deste artigo é identificar o perfil dos discentes, ingressantes e concluintes, dos cursos de graduação em secretariado executivo. A pesquisa foi realizada com os discentes de 11 Instituições de Ensino Superior (IES públicas brasileiras, estaduais e federais. O estudo configura-se como descritivo-exploratório, fazendo parte da amostra 507 discentes, sendo 311 ingressantes e 196 concluintes. Os principais resultados indicam que os discentes atuam em empresas de diversos segmentos, com destaque ao comércio e prestação de serviços; 87% são do gênero feminino e a faixa etária predominante é entre 17 a 24 anos. Destaca-se, como fator positivo, a atuação profissional dos discentes desde o início da graduação, exercendo as atribuições pertinentes ao profissional de secretariado executivo, o que revela que os discentes conseguem relacionar o que é aprendido em sala de aula com a prática profissional, o que também evidencia a aceitação do empresariado pelos profissionais de secretariado executivo.

    The objective of this paper is to identify the profile of beginner and graduate students who apply for Executive Secretariat graduation course. This research was carried out with students from 11 Brazilian public undergraduate schools, both federal and state ones. This is considered a descriptive and exploratory study, which analyzed 507 students, 311 beginners and 196 graduate ones. The main results show that students perform in different segment companies, but especially in service companies, 87% are female and the predominant age group is between 17 and 24 years old. In a positive way, this research stands out the factor that these students perform professionally since the beginning of the graduation, exerting the functions which are up to the Executive Secretariat professional. This reveals that the students are able to link what they have learned inside the classroom with the

  17. Efeitos do(s letramento(s na constituição social do sujeito: considerações fonoaudiológicas Effects of Literacy (ies on the social constitution of the subject: speech therapy considerations

    Directory of Open Access Journals (Sweden)

    Natally Ribeiro

    2012-10-01

    Full Text Available OBJETIVO: caracterizar e analisar, do ponto de vista fonoaudiológico, o(s letramento(s, os modos de circulação e uso de gêneros discursivos escritos por 69 escolares de duas classes de terceiro estágio de uma escola municipal de ensino infantil da cidade de São Paulo. MÉTODO: construção e aplicação de protocolo composto por diversos gêneros discursivos escritos, para verificação do grau de reconhecimento, de familiaridade e de uso dos mesmos pelos 69 escolares pesquisados. A faixa etária dos escolares é de 5 anos e 1 mês a 6 anos e 1 mês, sendo 58% do sexo masculino e 42%, feminino. A análise dos dados foi feita a partir do mapeamento dos índices de letramento dos escolares, em função dos níveis e tipos de letramento consignados na literatura especializada. RESULTADOS: entre os gêneros discursivos escritos apresentados, foi encontrado, para essa faixa etária, um reconhecimento significante para os gêneros: carta; jornalístico; narrativas infantis; placas de trânsito; quadrinhos e receitas, sendo estes visualizados e/ou utilizados por e/ou com familiares em casa, no trajeto à escola e em outros espaços sociais. CONCLUSÃO: é considerável a presença de práticas letradas entre os pesquisados, o que sugere a relevância em se considerar os processos de letramento, tanto nas estratégias pedagógicas da educação infantil, quanto no trabalho fonoaudiológico com escolares que apresentem dificuldades e/ou distúrbios na aquisição da escrita.PURPOSE: to characterize and analyze the speech-language point o view, literacy (ies, the modes of movement and use of discursive genres written by 69 students from two classes of the third stage of an elementary public school for children of São Paulo. METHOD: the construction and application protocol consists of several written genres for checking the degree of recognition, familiarity and usage by 69 schoolchildren. The age of the students was 5 years and 1 month to 6 years

  18. Greenhouse Gas Emissions and Global Warming Potential of Traditional and Diversified Tropical Rice Rotation Systems including Impacts of Upland Crop Management Practices i.e. Mulching and Inter-crop Cultivation

    Science.gov (United States)

    Janz, Baldur; Weller, Sebastian; Kraus, David; Wassmann, Reiner; Butterbach-Bahl, Klaus; Kiese, Ralf

    2016-04-01

    Paddy rice cultivation is increasingly challenged by irrigation water scarcity, while at the same time changes in demand (e.g. changes in diets or increasing demand for biofuels) will feed back on agricultural practices. These factors are changing traditional cropping patterns from flooded double-rice systems to the introduction of well-aerated upland crop systems in the dry season. Emissions of methane (CH4) are expected to decrease, while emissions of nitrous oxide (N2O) will increase and soil organic carbon (SOC) stocks will most likely be volatilized in the form of carbon dioxide (CO2). We measured greenhouse gas (GHG) emissions at the International Rice Research Institute (IRRI) in the Philippines to provide a comparative assessment of the global warming potentials (GWP) as well as yield scaled GWPs of different crop rotations and to evaluate mitigation potentials or risks of new management practices i.e. mulching and inter-crop cultivation. New management practices of mulching and intercrop cultivation will also have the potential to change SOC dynamics, thus can play the key role in contributing to the GWP of upland cropping systems. To present, more than three years of continuous measurement data of CH4 and N2O emissions in double-rice cropping (R-R) and paddy rice rotations diversified with either maize (R-M) or aerobic rice (R-A) in upland cultivation have been collected. Introduction of upland crops in the dry season reduced irrigation water use and CH4 emissions by 66-81% and 95-99%, respectively. Moreover, for practices including upland crops, CH4 emissions in the subsequent wet season with paddy rice were reduced by 54-60%. Although annual N2O emissions increased twice- to threefold in the diversified systems, the strong reduction of CH4 led to a significantly lower (psystem. Measurements of soil organic carbon contents before and three years after introduction of upland crop rotations indicated a SOC loss for the R-M system, while for the other

  19. POLITICA DE RECRUTARE ȘI SELECȚIE A PERSONALULUI ACADEMIC ÎN ÎNVĂȚĂMÂNTUL SUPERIOR DIN RSS MOLDOVENEASCĂ. 1944-1950

    Directory of Open Access Journals (Sweden)

    Liliana ROTARU

    2017-08-01

    Full Text Available Resursa umană este capitalul strategic al oricărei instituții de învățământ superior și o politică judicioasă de personal, în general, dar mai ales de recrutare și selecție a cadrelor didactico-științifice. Ea face posibilă realizarea misiunii învăță­mân­tului superior, implicit, prin cei care îl promovează. Cercetarea politicii de personal în școlile superioare din RSS Moldovenească în perioada de refacere a învățământului superior de după cel de-al Doilea Război Mondial a scos în evidență că aceasta era subordonată politicii naționale a statului sovietic, care presupunea formarea „omului nou” și integrarea acestuia în identitatea supraetnică numită „popor sovietic” – deznaționalizat, îndoctrinat cu ideologie marxist-leninistă, rusificat și rusianizat, care să aibă o patrie socialistă comună – Uniunea Sovietică și un scop comun – const­ruirea comunismului. Toate instrumentele și metodele de recrutare și selectare a personalului academic pentru insti­tuțiile de învățământ din RSS Moldovenească erau subordonate necesității creării unui corp didactico-științific în mare parte vorbitor și purtător de limbă și cultură rusă, puternic ideologizat și loial statului sovietic și partidului comunist, și mai apoi de o anumită competență profesională, toate acestea camuflate sub pregnanta idee de promovare a „elemen­tului autohton moldovenesc”.THE POLICY OF RECRUITMENT AND SELECTION OF ACADEMIC STAFF IN HIGHER EDUCATION OF MSSR. 1944-1950The human resource is the strategic capital of any higher education institutions and, in general, a judicious staff policy, but especially – a good policy of recruitment and selection of didactic and scientific staff makes possible to realize the higher education mission and, by default – the goals of those who are promoting it. The research of staff policy in high schools of MSSR during the higher education

  20. Call for Papers and Announcement Joint International Conference of Industrial Engineering and Engineering Management (IE&EM'2002)And International Conference on Electronic Commerce Engineering (ICECE'2002)%“2002年工业工程与工程管理国际会议(IE&EM’2002)”暨“2002年电子商务工程国际会议(IceCE’2002)”征文通知

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@(IE&EC'2002) 19-21 September 2002, Beijing, P. R. China Theme: Providing Comprehensive Solution to the Enterprise of Digital Economy Sponsored by * China Mechanical Engineering Society (CMES) * American Institute of Industrial Engineers * Institute of Industrial Engineers of Hong Kong * Japan Institute of Management Association * Industrial Engineering Institute of Korea * Society of Supply Chain Management, Korea * National Science Foundation of China * Institution of Electrical Engineers (IEE) Supported by * Springer-Verlag Organized by * Tsinghua University * Leeds Metropolitan University, UK * University of Science & Technology of Hong Kong * Industrial Engineering Institute, CMES * Production Engineering Institute, CMES Introduction The main theme of the conference is "Providing Comprehensive Solution to the Enterprise of Digital Economy. It aims at bringing together world-class researchers and professors in industrial engineering and e-commerce to address the major aspects such as business models, enabling technologies, engineering applications, human factor, and policy and security. The conference will focus on the emerging issues of industrial engineering and electronic commerce in the context of engineering services involving product innovation, manufacturing operations, logistics and supply chain, sales and marketing, customer services and technical supports. It is to provide a major forum for researchers and practitioners to review the past development, and to identify possible directions for further developments. The objectives of the conference 1.Establish linkages between researchers in industrial engineering and e-commerce from the perspectives of digital enterprise, as well as from different disciplines. 2.Promote a dynamic, integrative, inter-disciplinary and inter-country research agenda for e-commerce. 3.Encourage and promote the exchange between academic researchers and industrial practitioners in the field of digital enterprise. Event

  1. Independent Research (IR) and Independent Exploratory Development (IED)

    Science.gov (United States)

    1994-08-01

    Journal of Applied Social Psychology , 23, 508-536. Pedhazur, E. J. (1982). Multiple regression in... Journal of Applied Social Psychology , 23, 508-536. (Work done in FY85/86). Riemer, R. A. (1993, August). The effects of productivity gain sharing and... Journal of Applied Social Psychology , 23, 508-536. (Work done in FY85/86). Riemer, R. A. (1993, August). The effects of productivity gain sharing

  2. Gonadotropin Pulsatllity in FemaIe Long Distance Runners

    Science.gov (United States)

    1986-10-24

    prostaglandin the spiral arteries contract, effect . The endometrium, then lacking a sufficient blood supply, becomes necrotic and is sloughed off initiating... vegetarianism among amenorrheic athletes (Appenzeller, 1983). In contrast, some have found no .differences in nutritional status between amenorrheic and...perceived stress might also explain the lack of rise in B- endorphin after submaximal exercise in runners. E. EFFECTS OF EXERCISE ON SERUM CORTISOL

  3. Stakeholder Analysis for the CF Counter-IED Training Courses

    Science.gov (United States)

    2010-05-01

    Canada, as represented by the Minister of National Defence, 2010 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la...Element #1a Wedding guests arrived Yes MTP #1c Insufficient critique of answer 1 CoachScript MTP #1c Acquired SA Element #1b No cell phone activity...Acq MTP #2b Cultural sensitivity 0 CoachScript MTP #2b Acquired SA Element #2a Recent CF activity displaced ins Yes MTP #2c Insufficient critique of

  4. The Skills Implications of Electronic Retailing. IES Final Report.

    Science.gov (United States)

    Tackey, Nii Djan; Hillage, Jim; Jagger, Nick; Bates, Peter

    The skills and education/training implications of the development of electronic commerce in the United Kingdom's retail industry and its associated supply chain were examined. The major data collection activities were as follows: a literature review; consultation with leading academics and advisers; an e-mail-based call for information from…

  5. SIRE: A MIMO Radar for Landmine/IED Detection

    Science.gov (United States)

    2013-04-30

    www.globalissues.org/article/79/ landmines (Nov. 2009). [2] Montoya, T. and Smith, G., “Land mine detection using a ground - penetrating radar based on...Park, NC 27709-2211 15. SUBJECT TERMS ground penetrating radar , image reconstruction, RFI Ode Ojowui Jr, Jian Li Howard University 2400 6th Street...used by these radars provide the necessary ground penetration capabilities for detection and the wide bandwidth signals used are necessary for range

  6. The tax collection [? Southern Rhodesia (i.e. Zimbabwe)

    OpenAIRE

    Bathurst, Charles, 1867-1958, 1st Viscount Bledisloe

    2003-01-01

    Showing a man sitting at a desk in front of a thatched building, with three uniformed men standing in the foreground. The photograph is published in: Rhodesia-Nyasaland Royal Commission Report. Presented to Parliament by Command of His Majesty, March, 1939. London: H.M.S.O., 1939. The Rhodesia-Nyasaland Royal Commission arrived at Bulawayo on 16 May 1938, moved to Nyasaland (now called Malawi), reaching Zomba on 17 June, thence to Northern Rhodesia (now called Zambia) on 8 July, returning t...

  7. Muusikamaailm : Suvefestivalid täies hoos / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Suvefestivalidest : Aix-en-Provence'i festivalist, Londoni "Promenaadikontsertidest", Spoleto "Kahe maailma festivalist", Sapporo "Pacific Music Festival'ist", Bregenzi festivalist, New Yorgi Lincoln Center'i festivalist ja Verbieri festivalist

  8. Defeating Improvised Explosive Devices (IED): Asymmetric Threats and Capability Gaps

    Science.gov (United States)

    2011-03-23

    kilometer, some of the challenges include the reliability and availability of high power, room-temperature, tunable mid- wave infrared and long- wave ...U.S. Army EOD Operator assigned to the 707th EOD Company and deployed to Iraq, lost both of her arms above the elbow transporting an unknown...secondary explosives which will not detonate without a strong shock , for example, from a detonator. IEDs will also have some type of packaging or, in the

  9. Critical Pedagogy(ies) for ELT in Indonesia

    Science.gov (United States)

    Larson, Kasey R.

    2014-01-01

    This paper will explore the theoretical underpinnings that present a rationale for the use of critical pedagogy as an English Language Teaching (ELT) approach in Indonesia. A brief description of critical pedagogy is given, followed by a detailed rationale for its use including an overview of critical pedagogy studies done in Asia, an exploration…

  10. IES Integrated Learning Assessment Final Report. CRESST Report 788

    Science.gov (United States)

    Silver, David; Hansen, Mark; Herman, Joan; Silk, Yael; Greenleaf, Cynthia L.

    2011-01-01

    The main purpose of this study was to examine the effects of the Reading Apprenticeship professional development program on several teacher and student outcomes, including effects on student learning. A key part of the study was the use of an enhanced performance assessment program, the Integrated Learning Assessment (ILA), to measure student…

  11. CRITICAL PEDAGOGY(IES FOR ELT IN INDONESIA

    Directory of Open Access Journals (Sweden)

    KASEY R. LARSON

    2014-01-01

    Full Text Available This paper will explore the theoretical underpinnings that present a rationale for the use of critical pedagogy as an English Language Teaching (ELT approach in Indonesia. A brief description of critical pedagogy is given, followed by a detailed rationale for its use including an overview of critical pedagogy studies done in Asia, an exploration of the curriculum and teaching approach decreed by the Indonesian Ministry of Education and Culture, and calls for critical pedagogy by Indonesian scholars and teachers. This paper will conclude with some beginning steps that can be undertaken by teachers who want to implement a more critical approach to teaching.

  12. Muusikamaailm : Suvefestivalid täies hoos / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Suvefestivalidest : Aix-en-Provence'i festivalist, Londoni "Promenaadikontsertidest", Spoleto "Kahe maailma festivalist", Sapporo "Pacific Music Festival'ist", Bregenzi festivalist, New Yorgi Lincoln Center'i festivalist ja Verbieri festivalist

  13. Kümme aastat taasiseseisvunud Eestis / Õie Tammissaar

    Index Scriptorium Estoniae

    Tammissaar, Õie, 1949-

    2003-01-01

    Rets. rmt.: Raamatukogud ja raamatukogundus taasiseseisvunud Eestis 1991-2001 : artiklite kogumik = Libraries and librarianship in newly independent Estonia 1991-2001 : collection of articles / RR ; koost. Anu Nuut. Tallinn, 2002. 238 lk. : ill

  14. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  15. Aurel Ion Maican (II. Perioada ieşeană

    Directory of Open Access Journals (Sweden)

    Vera Molea

    2009-12-01

    Full Text Available Stage director Aurel Ion Maican has contributed decisively to the making of Romanian modern theatre in the interwar period. This monograph is the chronicle of an outstanding career. The author traces Maican's development as an artist and gives a detailed outline of his work. Influenced by European stage experiments of the time, Maican used new visual techniques and worked intensely with the actors, in order to refine their expressive means and to remove the clichés of the old naturalistic style. Step by step, Maican and a few other stage directors of the new generation succeeded in forging a poetic theatrical language where visual images, gesture, light and music equaled the power of the spoken word. In the course of his activity, Maican has directed a vast array of plays in various Romanian theatres. He gained notoriety in the early thirties with his productions at Jassy National Theatre. They are reviewed in this second chapter of the monograph, which provides relevant historical data, along with a number of documents as yet unpublished.

  16. iES - An Intelligent Electronic Sales Platform

    Energy Technology Data Exchange (ETDEWEB)

    Stanton, V L; Korbe III, W; Gao, J G

    2003-10-02

    Current e-commerce systems support online shopping based on electronic product catalogs. The major issues associated with catalog-based commerce systems are: difficulty in distinguishing one retailer from another, complex navigation with confusing links, and a lack of personalized service. This paper reports an intelligent solution to address these issues. Our solution will provide a more personalized sales experience through the use of a transaction-based knowledge model that includes both the rules used for reasoning as well as the corresponding actions. Based on this solution, we have developed an intelligent electronic sales platform that is supported by a framework which provides the desired personalization as well as extensibility and customization capabilities. This paper reports our design and development of this system and application examples.

  17. Lugu inimese üksindusest / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Veljo Käsperi filmist "Tütarlaps mustas" (1966). Operaator Harry Rehe, stsenarist Lilli Promet. Osades: Gerlinda Kopelman. Juozas Budraitis, Lisl Lindau, Viiu Härm, Jüri Järvet, Evald Hermaküla, Ellen Liiger. Filmi vastuvõtust. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  18. Work-Life Balance: Beyond the Rhetoric. IES Report.

    Science.gov (United States)

    Kodz, J.; Harper, H.; Dench, S.

    The current status of British policy and practice related to work-life balance was examined through case studies of six organizations identified as having well-developed work-life balance and flexible working practices. Interviews were conducted with human resource (HR) managers at all six organizations, and interviews and focus group discussions…

  19. Studying Masculinity(ies) in Books about Girls

    Science.gov (United States)

    Harper, Helen

    2007-01-01

    This study explored the nature and performance of masculinity portrayed in popular young adult novels featuring female protagonists. Although all had their limitations, the novels offered more complex renderings of gendered identity in the lives of female and male adolescent characters, addressed the effects of enforced traditional masculinity,…

  20. POLITICA DE DISTRIBUŢIE A COMPANIEI MODERNE

    Directory of Open Access Journals (Sweden)

    Grigore Aurica

    2007-05-01

    Full Text Available The economic environmment is in permenent change and the firms try to use more and more thetechnics and instruments of modern marketing. At all points of the modern marketing system people have formedassociations and eliminated various middlemen in order to achieve more efficient marketing. Manufacturersoften maintain their own wholesale departments and deal directly with retailers. Distribution channels can thushave a number of levels. Kotler defined the simplest level, which of direct contact with no intermediariesinvolved, as the 'zero-level' channel. The success condition of firm is represented by her adaptapted capacity,and flexibility to the demand coordinate and to the concurential environment.

  1. Automation of IED Threat Emplacement for Training Scenarios

    Science.gov (United States)

    2012-03-01

    eductions th the second pply route) C Toronto CR erarchy with taxonomy it efine the wa y inference. ge base pro nowledge ba e of applica at can be ma... efined . lass equivale , is a soft sur explicit and below show classification fore, a soft su avel road’ is avel road. I ncy. face item. C

  2. Learning from Cross-Functional Teamwork. IES Report 356.

    Science.gov (United States)

    Kettley, P.; Hirsh, W.

    A study was conducted to determine what knowledge and learning is developed through teamwork in business. Ten cross-functional teams selected from six major United Kingdom employers were surveyed, with structured interviews completed with 72 team members and team leaders and a short questionnaire completed by 50 of the interviewees. The study…

  3. STEREOTIPUL: DE LA COGNIŢIE LA IMAGINEA LITERARĂ

    Directory of Open Access Journals (Sweden)

    Onorina GRECU

    2007-06-01

    Full Text Available Stereotypes are as old as human culture itself. They reflectideas that groups of people hold about others who are different from them. Astereotype can be embedded in single word or phrase, an image, or acombination of words and images. The image evoked is easily recognizedand understood by others who share the same views.Stereotypes can be either positive or negative. This paper recalls thecognition process in creating stereotypes and their importance when literaryview is applied.

  4. Proyecto de instalaciones del edificio IES Salvador Dalí

    OpenAIRE

    López Riesco, Fernando

    2012-01-01

    Este edificio de 1987 estará dotado de un sistema de calefacción a base de emisores de calor alimentados por dos calderas a gas natural SAUNIER DUVAL THERMOSYSTEM CONDENS F200/3, de las cuales se ramificará una red de tuberías dividida en 4 circuitos formando una instalación bitubular. Un último circuito se encargará de calefactor el gimnasio y el pasillo central. El fluido caloportador será el agua. La distribución del fluido caloportador se realiza de forma forzada con bombas...

  5. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  6. Free, Fair and Efficient? Open Internal Job Advertising. IES Report.

    Science.gov (United States)

    Hirsh, W.; Pollard, E.; Tamkin, P.

    In the 1990s, many major employers in the United Kingdom have moved to more open internal job markets (OIJMs). OIJMs give the job of filling internal vacancies to line managers and employees who see the job advertised and apply for it. The development and operation of OIJMs at the following firms were studied: Rolls-Royce; British Gas Trading;…

  7. Free, Fair and Efficient? Open Internal Job Advertising. IES Report.

    Science.gov (United States)

    Hirsh, W.; Pollard, E.; Tamkin, P.

    In the 1990s, many major employers in the United Kingdom have moved to more open internal job markets (OIJMs). OIJMs give the job of filling internal vacancies to line managers and employees who see the job advertised and apply for it. The development and operation of OIJMs at the following firms were studied: Rolls-Royce; British Gas Trading;…

  8. Critical Pedagogy(ies) for ELT in Indonesia

    Science.gov (United States)

    Larson, Kasey R.

    2014-01-01

    This paper will explore the theoretical underpinnings that present a rationale for the use of critical pedagogy as an English Language Teaching (ELT) approach in Indonesia. A brief description of critical pedagogy is given, followed by a detailed rationale for its use including an overview of critical pedagogy studies done in Asia, an exploration…

  9. Language(s and identity(ies in french society Language(s and identity(ies in french society

    Directory of Open Access Journals (Sweden)

    Keizo Nanri

    2008-04-01

    Full Text Available The present paper has two purposes. The first is to demonstrate how homogeneous and innocuous editorials in Japanese major newspapers are. Specifically, I will first show that editorials whose political stance is anti-US/anti-government or neutral with respect to the US and Japanese governments’ decisions, frequently employ the rhetorical structure1 which leaves responsibility for solving critical issues to a large political system, and that this rhetorical structure prevents the text from providing the issues with specific and implementable solutions. I will then point out that, regardless of their political stance, Japanese editorials have a strong tendency to comment on events under discussion by raising the same issues at the same time within the framework of the central government’s policies. The second purpose is to argue that the elimination of editorial homogeneity and innocuousness requires the abolition of the kisha (press club system. The present paper has two purposes. The first is to demonstrate how homogeneous and innocuous editorials in Japanese major newspapers are. Specifically, I will first show that editorials whose political stance is anti-US/anti-government or neutral with respect to the US and Japanese governments’ decisions, frequently employ the rhetorical structure1 which leaves responsibility for solving critical issues to a large political system, and that this rhetorical structure prevents the text from providing the issues with specific and implementable solutions. I will then point out that, regardless of their political stance, Japanese editorials have a strong tendency to comment on events under discussion by raising the same issues at the same time within the framework of the central government’s policies. The second purpose is to argue that the elimination of editorial homogeneity and innocuousness requires the abolition of the kisha (press club system.

  10. Language(s and identity(ies in French society Language(s and identity(ies in French society

    Directory of Open Access Journals (Sweden)

    Henri Jeanjean

    2008-04-01

    Full Text Available Most discourses about France seem to imply that France is a homogeneous, monolingual, monocultural country. This is denying the cultural and linguistic diversity of the country. Regions were conquered throughout the centuries and the various regimes have always tried to eradicate regional languages and cultures, imposing French as the sole language, a powerful tool of colonisation. Resistance to the linguistic and cultural genocides have always been present. Until the second half of the 20th century this resistance was expressed only in linguistic terms. Recent events such as the Algerian war led to a new militancy and a political awareness slowly developed among the groups defending their minority languages and cultures. By denying their peoples, their rights to be educated and express themselves in their own language, French governments throughout the centuries have denied them their specific identity. Some attempts at improving the situation were made by Jack Lang, the then minister of Education, but his efforts to improve the place of regional languages in the Education system were thwarted by the State and Constitutional Councils. Regionalisation and the growing importance of the European Union may bring some changes to an otherwise bleak situation Most discourses about France seem to imply that France is a homogeneous, monolingual, monocultural country. This is denying the cultural and linguistic diversity of the country. Regions were conquered throughout the centuries and the various regimes have always tried to eradicate regional languages and cultures, imposing French as the sole language, a powerful tool of colonisation. Resistance to the linguistic and cultural genocides have always been present. Until the second half of the 20th century this resistance was expressed only in linguistic terms. Recent events such as the Algerian war led to a new militancy and a political awareness slowly developed among the groups defending their minority languages and cultures. By denying their peoples, their rights to be educated and express themselves in their own language, French governments throughout the centuries have denied them their specific identity. Some attempts at improving the situation were made by Jack Lang, the then minister of Education, but his efforts to improve the place of regional languages in the Education system were thwarted by the State and Constitutional Councils. Regionalisation and the growing importance of the European Union may bring some changes to an otherwise bleak situation

  11. Analysis of the teaching of homeopathy in pharmacy courses of three High Learning Institutions (IES in the State of Goiás. Análisis de la enseñanza e homeopatía en cursos de farmacia de tres Instituciones de Enseñanza Superior (IES del estado de Goiás. Análise do ensino da homeopatia em cursos de farmácia de três Instituições de Ensino Superior (IES do Estado de Goiás.

    Directory of Open Access Journals (Sweden)

    Juliana Soares de Morais

    2007-01-01

    Full Text Available Homeopathy is a medical approach fit to the principles that guide the Brazilian public health policy and agrees with the new paradigm in pharmaceutical education, with the focus on the human condition.Thence the importance of the teaching of homeopathy in pharmacy undergraduate courses. This study aimed to analyze the models for the teaching of homeopathy in three Institutions of Superior Education (IES in the State of Goiás and to verify its reflection on the level of knowledge on homeopathy expressed by the students. The study programs of the IES were analyzed and questionnaires were applied to students who had already attended homeopathy courses. The results allowed to verify that mistaken ideas on homeopathy were mainly expressed by the students who learned homeopathy as a subtopic of another more general subject. This variability in the models of homeopathy teaching may lead to qualitative diversity in the homeopathic understanding of the pharmacy professionals in the State of Goiás.

  12. Infective endocarditis (IE first diagnosed at autopsy: analysis of 31 cases in Ribeirão Preto, Brazil Endocardite infecciosa (EI com diagnóstico feito apenas à necrópsia: análise de 31 casos ocorridos entre 1992 e 1997, em Ribeirão Preto, Brasil

    Directory of Open Access Journals (Sweden)

    Luiz Tadeu M. FIGUEIREDO

    2001-08-01

    Full Text Available Thirty one infective endocarditis (IE fatal cases whose diagnosis was first obtained at autopsy were studied. The clinical data of these patients (Group 1 showed significant differences compared to other 141 IE cases (Group 2. The average age of 53 years in Group 1 patients was 18 years higher than that of Group 2. The Group 1 patients had a low frequency of IE predisposing heart disease. Both patient groups presented fever (about 87%, but a significant low frequency of cardiac murmur (25.8% was observed in Group 1 patients and echocardiography tests were performed in only 16.1%, suggesting that IE diagnosis was not suspected. Likewise, although most Group 1 patients appeared with severe acute illness, they did not present the classic IE clinical presentation. Blood cultures were performed in only 64.5% of the Group 1 patients. However, bacteria were isolated in 70% of these blood cultures and Staphylococcus aureus was isolated in 71.4%. The bacteria attacked mitral and aortic valves. Complications such as embolizations and cardiac failure occurred in almost half of the cases and they also presented with infections of the lungs, urinary tract, and central nervous system. Medical procedures were performed in practically all fatal cases whose diagnosis was first obtained at autopsy. Sepsis occurred in about half of the patients and it was followed by shock in more than 25%. This form of IE must be suspected in mature and in old febrile hospitalized patients having infection predisposing diseases, embolization, and suffering medical procedures.Trinta e um casos fatais de EI, que tiveram este diagnóstico apenas à necrópsia, foram analisados. Os dados clínicos destes pacientes (Grupo 1 mostrou diferenças significantes quando comparados aos de outros 141 casos de EI (Grupo 2. A idade média de 53 anos nos pacientes do Grupo 1 foi 18 anos mais alta que nos do Grupo 2. Os pacientes do Grupo 1 tiveram uma baixa freqüência de cardiopatias

  13. Staphylococcus aureus harbouring egc cluster coding for non-classical enterotoxins, involved in a food poisoning outbreak, Romania, 2012 / Staphylococcus aureus purtător de gene codante pentru enterotoxine non-clasice (cluster egc, implicat într-un focar de toxiinfecţie alimentară, România, 2012

    Directory of Open Access Journals (Sweden)

    Coldea Ileana Luminita

    2015-08-01

    Full Text Available În martie 2012, într-un judeţ din România, a fost raportat un focar de toxiinfecţie alimentară ce a afectat un număr de 30 de preşcolari. Debutul simptomelor (vărsături, diaree şi dureri abdominale, la 1-2 ore de la ingestia unui anumit produs alimentar (lapte, a sugerat o posibilă etiologie stafilococică a acestui focar.

  14. 15.SFPS "Ieņēmumi no līgumiem ar klientiem"un 16.SFPS "Noma" prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu

    OpenAIRE

    Dābola, Iveta

    2016-01-01

    Maģistra darba temats 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu. Maģistra darba mērķis - balstoties uz 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” standartu prasību izpēti un analīzi, novērtēt Latvijas likumdošanas atbilstību minēto standartu prasībām un sniegt priekšlikumus konkrētu jautājumu risināšanai Latvijas kontekstā. Maģistra darbā izpētīti LR normatīvie regulējumi un sta...

  15. MODELE DE VARIAŢIE A NIVELULUI FREATIC ÎN CONDIŢII DE SECETĂ. STUDIU DE CAZ BAZINUL SUPERIOR AL RÂULUI BÂRLAD (Patterns of variation of the groundwater in dry conditions. Case study Barlad upper basin

    Directory of Open Access Journals (Sweden)

    IONUŢ MINEA

    2012-04-01

    Full Text Available Fără existenţa unui sistem de alimentare cu apă a populaţiei, locuitorii din bazinul superior al râului Bârlad îşi asigură necesarul de apă direct din subteran prin intermediul fântânilor şi/sau puţurilor, localizate majoritatea în cadrul intravilanului, la nivelul lunicilor şi versanţilor (afectaţi frecvent de procese geomorfologice actuale alunecări de teren. În aceste condiţii realizarea unor studii legate de variaţia nivelului hidrostatic în subteran se impune, mai ales că în ultimii ani sub impulsul creşterii activităţilor economice consumatoare de apă (construcţii, agricultură etc., creşterea cererii pentru apă este foarte mare.Analiza variaţiilor nivelului hidrostatic s-a realizat pe baza măsurătorilor efectuate în peste 100 de puncte (fântâni şi puţuri, majoritatea situate în ariile locuite, în două campanii successive în decursul anului 2011 (aprilie-mai şi ocotmbrie. Evaluarea regimului hidrogeologic a scos în evidenţă o variaţie importantă, mai ales în condiţii de apariţie a secetei (septembrie-octombrie 2011 dar şi în funcţie de hidrostructurile geologice în care este cantonată apa freatică. Cele mai mari variaţii s-au înregistrat la nivelul hidrostructurilor de descărcare de la nivelul versanţilor (la baza depozitelor deluviale şi coluviale şi de la nivelul depozitelor aluvionare de terasă.

  16. Uso del software Geogebra en el aprendizaje de la geometría analítica, en el 5° grado de educación secundaria de la I.E. "Julio Cesar Escobar" S.J.M. en el 2012

    OpenAIRE

    Palacios Huaraca, Carlos Rubén

    2013-01-01

    Universidad Nacional de Educacion - UNE El propósito de ésta investigación fue estudiar el uso del software educativo libre Geogebra, en los estudiante del 5° Grado de Educación secundaria de la I.E. Julio Cesar Escobar en San Juan de Miraflores para que obtengan aprendizajes significativos de la geometría analítica, específicamente, en las temas de ecuación de la recta, ecuación de la circunferencia y la ecuación de la Parábola. El diseño metodológico de la investigación de tipo cuasi-exp...

  17. Análisis de los hábitos alimentarios de los alumnos de 3º de ESO del IES Honori García de La Vall d'Uixó y propuestade un plan de educación nutricional enmarcado en el Plan de Acción Tutorial

    OpenAIRE

    Arnau Oset, Cristina

    2016-01-01

    Treball Final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes. Codi: SAP139. Curs acadèmic: 2015-2016 El presente Trabajo Final de Máster responde a la modalidad de “Mejora Educativa”, trabajado con una metodología de investigación-acción que se enmarca y se basa en mi estancia en prácticas en el IES Honori García de La Vall d’Uixó (Castellón) y responde a la necesidad de mejorar los hábitos alimentarios ...

  18. 基于神经网络及相似日的城市交通流量预测模型研究%Traffic FIow Forecasting ModeI Based on NeuruaI Network and SimiIar Day PrincipIe

    Institute of Scientific and Technical Information of China (English)

    张佳宁

    2016-01-01

    In order to soIve the traffic fIow forecasting probIem in inteI igent traffic system,this paper proposes a predic-tion modeI of traffic fIow based on neuraI network and simiIar day principIe.Urban traffic is affected by traffic capacity of the road,working days or hoIidays,snow and fog weather.The infIuence of such factors as due to the simiIar conditions of traffic fIow has great reIevance.This paper introduces a modeI based on simiIar day principIe and neuraI network.%针对智能运输交通系统中的交通流量预测问题,提出了采用基于神经网络及相似日的交通流量预测模型。城市交通流量受到道路本身的通行能力、工作日与节假日、雨雪雾天气等因素的影响。由于相似条件下的交通流量具有较大的关联性,基于差异性和相关性原理,提出了基于相似日和神经网络的城市交通流量预测模型。以实际交通数据进行实验仿真,结果证明本文提出的预测模型具有较好的误差精度,具有实用性。

  19. 转cry1Ie基因玉米残体对赤子爱胜蚓的生长发育及体内酶活性的影响%Effects of Residues of Transgeniccry1Ie Corn on Development and Enzyme Activities ofEisenia foetida

    Institute of Scientific and Technical Information of China (English)

    崔蕾; 白树雄; 张天涛; 刘允军; 何康来; 王振营

    2014-01-01

    Bacillus thuringiensisinsecticidal protein expressed in transgenic corn can be released into soil through root exudates and upon decomposition of the plant residues. The fate of the insecticidal Cry1Ie protein from plant residues of the transgeniccrylIe corn was studied in the soil-dwellingEisenia foetida, by measuring the effects of Bt-corn on growth, development and enzyme activities of the earthwormE. foetida under various trial conditions. Finely ground Bt-corn leaves and stalks added to soil had no deleterious effects on survival and did not result in significant changes in growth and development ofE. fetida. The activities of SOD and POD ofE. fetida in 50B+0N (50 g Bt/500 g soil) group were significant higher than that in 0B+50N (50 g non-Bt/500 g soil) group, suggesting that Bt corn could induce the activities of SOD and POD ofE. fetida within a short time. No differences in protein contents andthe activities of AChE and CAT were detected between treatment groups.%转 Bt 基因抗虫玉米通过根系分泌物或植株残体降解等方式将植株表达的 Bt 杀虫蛋白释放到土壤中。本文通过在人工土壤中添加磨碎的转cry1Ie基因玉米植株残体来饲养赤子爱胜蚓Eisenia foetida,研究了转cry1Ie基因玉米植株残体对赤子爱胜蚓生长发育及体内酶活性的影响。结果显示,在63 d的试验中,添加转 cry1Ie 基因玉米植株残体处理组没有引起赤子爱胜蚓的死亡。5个处理组与对照组中每7 d的蚯蚓体重、产茧数量、茧孵化数量均没有显著差异。SOD酶和POD酶活力随Bt玉米植株残体组织含量的增加而增加,50B+0N(50 g Bt/500 g土壤)处理组中SOD酶和POD酶活力要显著高于0B+50N(50 g non-Bt/500 g土壤)对照组。因此,Bt玉米植株残体可以在7 d时诱导赤子爱胜蚓SOD酶和 POD酶活性。但5个处理组与对照组中赤子爱胜蚓的总蛋白含量、AChE和CAT酶活力没有显著的差异。

  20. The demise of Leptotheca Thélohan, 1895 (Myxozoa: Myxosporea: Ceratomyxidae) and assignment of its species to Ceratomyxa Thélohan, 1892 (Myxosporea: Ceratomyxidae), Ellipsomyxa Køie, 2003 (Myxosporea: Ceratomyxidae), Myxobolus Bütschli, 1882 and Sphaerospora Thélohan, 1892 (Myxosporea: Sphaerosporidae).

    Science.gov (United States)

    Gunter, Nicole; Adlard, Robert

    2010-02-01

    A revision of Leptotheca Thélohan, 1895 is presented. The boundaries that separate Leptotheca from Ceratomyxa Thélohan, 1892 and Sphaerospora Thélohan, 1892 are vague and have been highlighted as an area of concern within myxosporean classification. A survey of the literature revealed 63 species that are currently assigned to Leptotheca and a further 11 species that have been relegated as synonyms in Ceratomyxa, Sphaerospora or Myxobolus Bütschli, 1882. The placement of some species in the genus is unclear and demonstrates the need for a revision. The type-species of Leptotheca (L. agilis Thélohan 1892) has many Ceratomyxa-like characters, such that a minor amendation of the diagnosis of Ceratomyxa will then accept the type-species of Leptotheca, rendering the latter genus its synonym. We propose the suppression of Leptotheca, with all species currently assigned to that genus reassigned to Ceratomyxa, Ellipsomyxa Køie, 2003, Myxobolus or Sphaerospora on the basis of appropriate morphological and biological traits. The diagnoses of Ceratomyxa and Ellipsomyxa are amended appropriately. Molecular analysis may change the placement of some species in the future; however, the aim of this review was to eliminate the ambiguity of assignment of species in the genera Leptotheca, Ceratomyxa and Sphaerospora by suppressing Leptotheca.

  1. AMENINȚAREA SAU VIOLENȚA SĂVÂRȘITĂ ASUPRA UNEI PERSOANE CU FUNCȚIE DE RĂSPUNDERE SAU A UNEI PERSOANE CARE ÎȘI ÎNDEPLINEȘTE DATORIA OBȘTEASCĂ (art.349 DIN CODUL PENAL: ANALIZĂ DE DREPT PENAL

    Directory of Open Access Journals (Sweden)

    Vitalie STATI

    2017-07-01

    Full Text Available Obiectul studiului de față îl formează elementele constitutive și circumstanțele agravante ale infracțiunilor specificate la art.349 CP RM. În rezultatul analizei efectuate, se stabilește că obiectul juridic special al acestor infracţiuni are un caracter multiplu. Se relevă că victimă a infracţiunilor prevăzute la art.349 CP RM este, după caz: a persoana cu funcţie de răs­pundere; b persoana care îşi îndeplineşte datoria obştească; c ruda apropiată a persoanei cu funcţie de răspundere sau a persoanei care îşi îndeplineşte datoria obştească. Se arată că, în cazul infracţiunilor specificate la art.349 CP RM, legătura dintre comiterea infrac­ţiunii şi activitatea de serviciu sau obştească a victimei are un caracter obligatoriu. De fiecare dată, la calificare, urmează să se verifice dacă au fost încălcate sau nu regle­mentările care stabilesc condiţiile şi limitele îndeplinirii de către victimă a obligaţiilor de serviciu sau obşteşti. Doar în lipsa unor asemenea încălcări poate fi aplicat art.349 CP RM. Se ajunge la concluzia că art.349 CP RM nu poate fi aplicat în cazul în care, la momentul comiterii infrac­ţiu­nii, făptuitorul nu-şi dădea seama că: a săvârşeşte infracţiunea asupra unei persoane cu funcţie de răspundere care îşi desfăşoară activitatea în cadrul unei autorităţi publice, a unei persoane care îşi îndeplineşte datoria obştească sau a unei rude apropiate a acestora; b infracţiunea pe care o săvârşeşte are legătură cu i activitatea de serviciu a persoanei cu funcţie de răspundere care îşi desfăşoară activitatea în cadrul unei autorităţi publice sau cu ii activitatea obştească a persoanei care îşi îndeplineşte datoria obştească. Se argumentează că răzbunarea în legătură cu îndeplinirea de către victimă a datoriei obşteşti poate deter­mina comiterea infracţiunilor prevăzute la art.349 CP RM. Totodată, r

  2. Internacionalização na produção de conhecimento em IES Brasileiras: cooperação internacional tradicional e cooperação internacional horizontal Internationalization of the knowledge production on Brazilian Higher Education Institutions: international tradition cooperation and international horizontal cooperation

    Directory of Open Access Journals (Sweden)

    Marília Costa Morosini

    2011-04-01

    Full Text Available A produção do conhecimento científico no país está sediada, prioritariamente, na pós-graduação. Este artigo analisa a cooperação internacional nesse nível de educação. As fontes dos dados são relatórios institucionais e informações com técnicos do CNPq e da Capes e abordam: acordos bilaterais e multilaterais, estrangeiros com bolsa no país e brasileiros com bolsa no exterior. As análises confirmam a presença do modelo periférico de internacionalização nas IES, apesar da crescente internacionalização na pesquisa e na pós-graduação do país. Apontam também para a convivência de dois modelos de cooperação internacional: a predominância do modelo de Cooperação Internacional Tradicional - CIT, fundamentado na competitividade e na ocupação de espaço no mercado globalizado, e a tendência, embora de menor porte, a partir de 2003, do modelo de Cooperação Internacional Horizontal - CIH, fundamentado na consciência internacional e no fortalecimento da capacidade científica endógena dos parceiros mais fragilizados.The Brazilian scientific knowledge production is realized, basically, in the graduate education level. This paper analyses the international cooperation in this education level. The sources of the dates are institutional reports and information with the staff of the CNPq and CAPES and studies about bilateral and multilateral agreements, foreign with scholarship in the country and Brazilians with scholarship in the other countries. The results confirm the presence of the internationalization periphery model in the HEIs despite the expansion of the internationalization at the research and at the graduate level. The results show the coexistence of the two internationalization models: the predominance of the traditional international cooperation - CIT, based in the competition and in the collocation in the globalized labor market and the tendency, in spite of little, from 2003, of the Horizontal

  3. AppIication of Tobacco SaIes Customer ReIationship Management AIgorithm for Extracting ReIations Based on Graph%基于关系图提取算法的烟草销售客户关系管理的应用研究

    Institute of Scientific and Technical Information of China (English)

    周庆燕; 何利力

    2014-01-01

    展望客户关系管理,数据挖掘技术在其中起到了至关重要的作用,它可以挖掘出千万数据中的有用信息,企业才能对客户进行各类价值分类,然后预测客户的行为,从而做出正确有效的决策。在CRM应用中,基于数据挖掘技术的基础上,结合CRM系统的不足,为避免或减少客户管理系统因管理不到位而导致客户的流失,造成企业的损失,提出了客户关系图的提取算法,很好地分析了数据挖掘技术在CRM中的应用。%Prospect of customer reIationship management,data mining technoIogy to the important roIe in the pIay,it can dig out usefuI information hidden in the tens of miI ions behind the data,enterprises can be of vaIue to segment customer,then pre-dict customer behavior,thus to make correct and effective decision making.This paper in the CRM appIication,foundation based on data mining technoIogy,combined with the probIems of CRM system,in order to avoid or reduce the Ioss of cus-tomers due to improper management customer management system,resuIting in the Ioss of the enterprise,puts forward the aIgorithm of extracting customer reIationship graph,very good anaIysis of the appIication of data mining technoIogy in CRM.

  4. A autoavaliação institucional no processo de tomada de decisão em IES: estudo de caso das Faculdades SENAC/SC Institutional self-evaluation in the decision-making process at HEIs: a case study of SENAC/SC higher education school

    Directory of Open Access Journals (Sweden)

    Elita Grosch Maba

    2012-07-01

    Full Text Available O presente artigo pretende demonstrar em seu contexto a relação existente entre o sistema de autoavaliação institucional e o processo de tomada de decisão, especificamente nas Faculdades de Tecnologia pertencentes à Administração Regional do SENAC-SC. Utilizando uma amostra intencional deste universo, o estudo, realizado em 2010, é caracterizado como descritivo-exploratório, do tipo quali-quantitativo, mediante a aplicação de uma pesquisa bibliográfico-documental, configurada como um estudo multicaso. Nas seis unidades investigadas, foram entrevistados: o diretor da unidade e os coordenadores de áreas (Núcleo Relações com o Mercado, Núcleo Administrativo Financeiro e Núcleos Educacional Básico e do Ensino Superior, aplicando-se um questionário estruturado com questões abertas e fechadas, permitindo a avaliação de aspectos objetivos e quantificáveis e subjetivo-discursivos. Os resultados apontam para a autoavaliação institucional como facilitadora do processo decisório, provendo informações que permitem avaliar determinada situação. Adicionalmente, identificam os pontos fortes e fracos da IES e que melhoram a qualidade das decisões estratégicas, o que confirma a existência da relação pressuposta acima, bem como a importância do processo de autoavaliação institucional. Mostram, ainda, a necessidade de revisão da estrutura, visando aprimorar a apropriação dos dados levantados pela autoavaliação e aplicados como suporte no processo de tomada de decisão das instituições do universo analisado. Por fim, a hipótese de pesquisa, em base a esses resultados, acabou sendo validada, ratificando tal relação.This article presents, briefly, the master thesis that gave rise and that analyzes the institutional self-evaluation and the decision-making process at SENAC-SC and the relationship between them. By using an intentional sample of six technology universities belonging to the regional administration of SENAC

  5. Better than energy efficiency class IE2. Energy conservation potential with highly efficient glanded pumps; Besser als Energieeffizienzklasse IE2. Einsparpotentiale mit hocheffizienten Trockenlaeuferpumpen

    Energy Technology Data Exchange (ETDEWEB)

    Teders, Klaus

    2013-02-01

    In the building services, energy efficiency has developed to a mega trend long ago. This was independent from the energy policy turnaround in Germany. Thus, the technical planner has to consider efficiency criteria for the planning and selection of pumps for large heating and climate cycles. These efficiency criteria result from the new EU regulations for electrical-powered engines. There are significant differences between prescribed efficiency classes and technologically possible efficiency classes having impacts on the planning and later operational costs.

  6. A summary of the performance of exposure rate and dose rate instruments contained in instrument evaluation reports NRPB-IE1 to NRPB-IE13

    CERN Document Server

    Burgess, P H

    1979-01-01

    The various radiations encountered in radiological protection cover a wide range of energies and radiation measurements have to be carried out under an equally broad spectrum of environmental conditions. This report is one of a series intended to give information on the performance characteristics of radiological protection instruments, to assist in the selection of appropriate instruments for a given purpose, to interpret the results obtained with such instruments, and, in particular, to know the likely sources and magnitude of errors that might be associated with measurements in the field. The radiation, electrical and environmental characteristics of radiation protection instruments are considered together with those aspects of the construction which make an instrument convenient for routine use. To provide consistent criteria for instrument performance, the range of tests performed on any particular class of instrument, the test methods and the criteria of acceptable performance are based broadly on the a...

  7. Production TechnoIogy of PickIed Leisure VegetabIe%泡制休闲蔬菜生产技术

    Institute of Scientific and Technical Information of China (English)

    斯波

    2015-01-01

    Pickled leisure vegetable is a new industry,which is not only a big breakthrough of the future leisure way of eating,but also the necessity of vegetable products development.A variety of vegetables can be made into leisure vegetable food;eating aqueous food is a miracle,which has been popular in some areas for a long time,and has been widely spread among consumers,the latest technology constantly to be realized is a big trend.%泡制休闲蔬菜是一个新兴行业,这是未来休闲吃法的一大突破,也是蔬菜制品不断发展的必然。多种蔬菜均可以做成休闲蔬菜食品,含水食用也是奇迹,在部分地区流行之久,不断被消费者广为流传,这方面最新技术不断得到实现是一大趋势。

  8. 亚太首发ie:3内饰概念展示车:体现未来汽车内饰与电池解决方案——江森自控携座椅、内饰、电子及电池产品亮相2011上海车展%Johnson Controls Bring Auto-chair, Interior-decoration and Electronic Products and Battery to Auto Shanghai 2011

    Institute of Scientific and Technical Information of China (English)

    肖献法

    2011-01-01

    @@ 2011上海国际车展上,江森自控全面展示了座椅、内饰、电子及电池等全球化创新产品,并于2011年4月20日,揭幕了其集空间宽敞、操作灵活、设计轻量化以及令人难以置信的舒适体验于一身的ie:3内饰概念展示车,立体化地展现了其在座椅、内饰、电子产品、电池及系统方面的供应能力.据悉这也是在亚太地区首次亮相.

  9. Posibile sisteme de justiție administrativă - Examen de drept comparat

    Directory of Open Access Journals (Sweden)

    Dacian C. DRAGOŞ

    2002-06-01

    Full Text Available The article presents the main models of administrative justice, the differences between them and the importance of chosing one or another. Romania, being engaged in a proces of modernisation of the national administration, has to take care also of the means to control the administration, the most important of which is the judicial control of administrative decisions. Over the years, two systems have struggled for supremacy in administrative justice: the French system, characterized by the existence of the administrative courts, separate from the judicial courts, and the British system, where all law suits, including the administrative ones, are judged by judicial courts.

  10. Engine fuel trends in the 90ies. Kraftstoff-Trends in den 90er Jahren

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, J.

    1990-06-01

    The operating behaviour of internal combustion engines is greatly dependent from the properties and compositions of the fuels. Increasing demands made on engine technology for improved cost-effectiveness, service life and pollutivity will result in greater demands on the vehicle fuel quality. A number of papers whose contents are briefly reported by the author, deal with today's requirements of the automative industry on vehicle fuels (table: characteristics, requirements, limits, comments) and with the prospects of alternative fuels. Another paper discussed the influence of the fuel on particulate emission by diesel engines. Another paper presented the calculation of physical fuel data from the carburettor substance analysis and its significance, the environmentally relevant effects of fuel additives in enginer, and optimized additive systems to meet greater quality demands on otto-engine fuels. (HWJ).

  11. Including Quantum Effects in the Dynamics of Complex (i.e., Large)Molecular Systems

    Energy Technology Data Exchange (ETDEWEB)

    Miller, William H.

    2006-04-27

    The development in the 1950's and 60's of crossed molecular beam methods for studying chemical reactions at the single-collision molecular level stimulated the need and desire for theoretical methods to describe these and other dynamical processes in molecular systems. Chemical dynamics theory has made great strides in the ensuing decades, so that methods are now available for treating the quantum dynamics of small molecular systems essentially completely. For the large molecular systems that are of so much interest nowadays (e.g. chemical reactions in solution, in clusters, in nano-structures, in biological systems, etc.), however, the only generally available theoretical approach is classical molecular dynamics (MD) simulations. Much effort is currently being devoted to the development of approaches for describing the quantum dynamics of these complex systems. This paper reviews some of these approaches, especially the use of semiclassical approximations for adding quantum effects to classical MD simulations, also showing some new versions that should make these semiclassical approaches even more practical and accurate.

  12. Detection and characterization of spacer integration intermediates in type I-E CRISPR-Cas system.

    Science.gov (United States)

    Arslan, Zihni; Hermanns, Veronica; Wurm, Reinhild; Wagner, Rolf; Pul, Ümit

    2014-07-01

    The adaptation against foreign nucleic acids by the CRISPR-Cas system (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins) depends on the insertion of foreign nucleic acid-derived sequences into the CRISPR array as novel spacers by still unknown mechanism. We identified and characterized in Escherichia coli intermediate states of spacer integration and mapped the integration site at the chromosomal CRISPR array in vivo. The results show that the insertion of new spacers occurs by site-specific nicking at both strands of the leader proximal repeat in a staggered way and is accompanied by joining of the resulting 5'-ends of the repeat strands with the 3'-ends of the incoming spacer. This concerted cleavage-ligation reaction depends on the metal-binding center of Cas1 protein and requires the presence of Cas2. By acquisition assays using plasmid-located CRISPR array with mutated repeat sequences, we demonstrate that the primary sequence of the first repeat is crucial for cleavage of the CRISPR array and the ligation of new spacer DNA.

  13. Reduced Kernel IE's for MEN Based Analysis of Multilayered FSS Structures

    NARCIS (Netherlands)

    Monni, S.; Neto, A.; Tijhuis, A.G.

    2006-01-01

    Despite the fact that the general behavior of periodic structures has been investigated for many decades, the analysis and design of multilayered FSS's is still a very actual and complicated problem. This is especially true for stringent requirements, which rise for example when the FSS has to be in

  14. Skills for a Competitive Future: A Survey for the Pharmaceutical Industry National Training Organisation. IES Report.

    Science.gov (United States)

    Jagger, Nick; Aston, Jane

    This report focuses on a study that examined skills, recruitment, and training issues covering the whole pharmaceutical industry. It presents mailed survey material complemented and enhanced by a series of telephone interviews and focus groups. Chapter 1 is an introduction. Chapter 2 deals with the structure of the sector and reports background…

  15. Insecticidal and Repellent Activit ies of Laurinterol from the Okinawan Red Alga Laurencia nidifica

    Directory of Open Access Journals (Sweden)

    Takahiro Ishii

    2017-01-01

    Full Text Available An ethyl acetate (EtOAc extract of Laurencia nidifica was found to have toxic effect against brine shrimp larvae (Artemia salina. Bioassay-guided fractionation of the EtOAc extract resulted in the isolation of four known halogenated sesquiterpenes, laurinterol (1, isolaurinterol (2, aplysin (3, and a -bromocuparene (4. Their structures were established on the basis of spectral analysis and comparison with literature data. Among isolated compounds, only laurinterol showed strong toxicity against A. salina. Further experiments revealed that laurinterol also exhibited repellent activity against the maize weevil Sitophilus zeamais , insecticidal activity against the termite Reticulitermes speratus, and acetylcholinesterase (AChE inhibitory effect . This is the first report of insecticidal and repellent activities of laurinterol.

  16. An Analysis of Learner Autonomy and Learning Strateg ies in CALL Environment

    Institute of Scientific and Technical Information of China (English)

    何为芳

    2008-01-01

    In recent years,computer assisted language learning(CALL)increasingly attracts language learners'attentions with evident advantages.This paper introduces the basic concepts concerning CALL.learner autonomy and learning strategies,and tentatively proposes suggestions for developing language learners'strategies in CALL environment based on CALL situations in China.

  17. Skills for a Competitive Future: A Survey for the Pharmaceutical Industry National Training Organisation. IES Report.

    Science.gov (United States)

    Jagger, Nick; Aston, Jane

    This report focuses on a study that examined skills, recruitment, and training issues covering the whole pharmaceutical industry. It presents mailed survey material complemented and enhanced by a series of telephone interviews and focus groups. Chapter 1 is an introduction. Chapter 2 deals with the structure of the sector and reports background…

  18. A Standardized Procedure for a Pre-evaluation of the IED Instance

    Science.gov (United States)

    Panepinto, Deborah; Ruffino, Barbara; Zanetti, Mariachiara; Genon, Giuseppe

    2016-04-01

    This study presents a procedure, called EICS (Enterprise IPPC Compatibility Study) aimed at evaluating, by means of the calculation of three indexes, the compliance of the processes performed in an industrial plant with the guidelines provided by BREFs (BAT References) Documents. In fact, according to European Directive 2010/75/EU (concerning the Integrated Pollution Prevention and Control and repealing European Directive 2008/01/EC), industrial plants must require authorizations to the competent authority stating the conformity of their activity, in order to obtain this conformity they are advised to Best Available Technologies (BAT). The aim of the BATs is to avoid or minimize the impact of an industrial activity on the environment through the prevention of the atmospheric emissions, wastewater discharge and energetic consumption, and the correct waste management thus improving the efficiency of the plant. The procedure shown in the present paper has been tested on several types of industrial plant (cement plants, secondary smelt foundries, paper-mill, and automotive industries as regards their paint lines). In this paper, the application of EICS method to a cement plant is presented: the obtained results highlight a good correlation between the index values and the real situation of the plant.

  19. Sequential Pattern Detection and Time Series Models for Predicting IED Attacks

    Science.gov (United States)

    2009-03-01

    customer purchases spaghetti sauce at the grocery store, do they also purchase some kind of meat and pasta noodles? Knowing what items a shopper tends...CRISP-DM 1.0, 1st ed., v.1. CRISP-DM Consortium, 2000. Hidber, C. " Online Association Rule Mining," paper presented at the ACM SIGMOD International

  20. Smokeless Propellants as Vehicle Borne IED Main Charges: An Initial Threat Assessment

    Science.gov (United States)

    2008-01-01

    of equating blast damage from different explosives it has long been the custom to rate the output of explosives as a percentage ofthe output of TNT...size, composition and MREL ’I’HI:: Dhl <LAUKATIUN TU DhTUNA:llUN TRAN,s1𔃻’lUN UNiUN AND SMALL ARMS PROPELLANTS - A STUDY AND REVIEW - 0-5 ’NOMINAL

  1. Schengen Facility hankeprojektid on täies hoos / Helena Loorents

    Index Scriptorium Estoniae

    Loorents, Helena

    2005-01-01

    Schengen Facility toetusest uutele EL-i liikmesriikidele. Schengen Facility programmi vahenditest toetatakse Eesti piirivalvele RIB C-1100 tüüpi paatide ning piirivalvekopter hankimist, valminud on uus merevalvekeskus

  2. A neutron Albedo system with time rejection for landmine and IED detection

    Science.gov (United States)

    Kovaltchouk, V. D.; Andrews, H. R.; Clifford, E. T. H.; Faust, A. A.; Ing, H.; McFee, J. E.

    2011-10-01

    A neutron Albedo system has been developed for imaging of buried landmines and improvised explosive devices (IEDs). It involves irradiating the ground with fast neutrons and subsequently detecting the thermalized neutrons that return. A scintillating 6Li loaded ZnS(Ag) screen with a sensitive area of 40 cm×40 cm is used as a thermal neutron detector. Scintillation light is captured by orthogonal arrays of wavelength-shifting fibers placed on either side of the scintillator surface and then transferred to X and Y multi-pixel PMTs. A timing circuit, used with pulsed neutron sources, records the time when a neutron detection takes place relative to an external synchronization pulse from the pulsed source. Experimental tests of the Albedo system performance have been done in a sand box with a 252Cf neutron source (no time gating) and with pulsed D-D (2.6 MeV) neutrons from the Defense R&D Ottawa Van de Graaff accelerator (with time gating). Information contained in the time evolution of the thermal neutron field provided improved detection capability and image reconstruction. The detector design is described and experimental results are discussed.

  3. A neutron Albedo system with time rejection for landmine and IED detection

    Energy Technology Data Exchange (ETDEWEB)

    Kovaltchouk, V.D., E-mail: kovaltchoukv@bubbletech.ca [Bubble Technology Industries, Chalk River, Ontario (Canada); Andrews, H.R.; Clifford, E.T.H. [Bubble Technology Industries, Chalk River, Ontario (Canada); Faust, A.A. [Defense R and D Canada-Suffield, Medicine Hat, Alberta (Canada); Ing, H. [Bubble Technology Industries, Chalk River, Ontario (Canada); McFee, J.E. [Defense R and D Canada-Suffield, Medicine Hat, Alberta (Canada)

    2011-10-01

    A neutron Albedo system has been developed for imaging of buried landmines and improvised explosive devices (IEDs). It involves irradiating the ground with fast neutrons and subsequently detecting the thermalized neutrons that return. A scintillating {sup 6}Li loaded ZnS(Ag) screen with a sensitive area of 40 cmx40 cm is used as a thermal neutron detector. Scintillation light is captured by orthogonal arrays of wavelength-shifting fibers placed on either side of the scintillator surface and then transferred to X and Y multi-pixel PMTs. A timing circuit, used with pulsed neutron sources, records the time when a neutron detection takes place relative to an external synchronization pulse from the pulsed source. Experimental tests of the Albedo system performance have been done in a sand box with a {sup 252}Cf neutron source (no time gating) and with pulsed D-D (2.6 MeV) neutrons from the Defense R and D Ottawa Van de Graaff accelerator (with time gating). Information contained in the time evolution of the thermal neutron field provided improved detection capability and image reconstruction. The detector design is described and experimental results are discussed.

  4. Dragon’s Claws: The Improvised Explosive Device (IED) as a Weapon of Strategic Influence

    Science.gov (United States)

    2009-03-01

    George Orwell , “You and the Atomic Bomb,” (1945), http://www.george- orwell.org/You_and_the_Atomic_Bomb/index.html (accessed January 15, 2009). 7...Brassey’s, 1990. Orwell , George . “You and the Atomic Bomb,” 1945. http://orwell.ru/library/articles/ABomb/english/e_abomb (accessed January 26...McCormick Second Reader: George Lober THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting

  5. IE6摇身变作"多标签"浏览器

    Institute of Scientific and Technical Information of China (English)

    周玲生

    2006-01-01

    @@ 时下"多标签"式浏览器蔚然成风,无论是先前的Green Browser、Maxthon、Firefox、Opera还是新近的Internet Explorer 7.0 beta 2,无不以"多标签"浏览作为重要特征加以宣传.诚然,"多标签"浏览器允许在同一窗口内打开任意多个标签,无疑能降低系统资源的占用率,提高网民们冲浪的效率.

  6. Distribution and mechanism of Type I-E CRISPR-Cas systems

    NARCIS (Netherlands)

    Staals, R.H.J.; Brouns, S.J.J.

    2013-01-01

    Although the CRISPR type I system encompasses six different subtypes (I-A to I-F), only three subtypes have been studied in detail to date. This review includes an analysis of the distribution of CRISPR-Cas systems among the different bacterial and archaeal lineages, and will focus on our

  7. BDTPS The BNCT Treatment Planning System jointly developed at DIMNP and JRC/IE

    CERN Document Server

    Daquino, G G; Mazzini, M; Moss, R; Muzi, L; International Workshop on "Neutron Capture Therapy: State of the art"

    2003-01-01

    The idea to couple the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the new methodology set-up at DIMNP of University of Pisa, in collaboration with the JRC of Petten (NL). The methodology has been implemented in the new TPS, called BDTPS (Boron Distribution Treatment Planning System), which takes into account the actual boron distribution in the patient brain, while the standard TPS assumes a uniform boron distribution, absolutely far from the reality. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The new TPS, based on the Monte Carlo technique, has been validated comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designed, as calculated by the BDTPS and by the standard TPS SERA. An evident SERA overestimation of the thermal neutron flux, as well as the boron dose, has been detect...

  8. Intellectuele-eigendomsrechten als verhaalsobject : verhaal van vorderingen door uitwinning van ie-rechten in Nederland

    NARCIS (Netherlands)

    Keur, A.I.

    2016-01-01

    Purpose of this research is to explore to what extent it is possible and useful to collect debts by sale of intellectual property rights (ip-rights) under execution in the Netherlands governed by the laws of the Netherlands. Due to their specific characteristics ip-rights “behave” differently than o

  9. Astronomy and Geology Vocabulary, I.e. "NASA Words" in Native American Languages

    Science.gov (United States)

    Angrum, A.; Alexander, C. J.; Martin, M.

    2014-12-01

    The US Rosetta Project has developed a program in Native American communities in which contemporary STEM vocabulary is taught alongside the same vocabulary in Navajo. NASA images and science are used and described in the native language, alongside both lay English, and scientific English. Additionally, science curriculum (geology/chemistry/botany/physics) elements drawn from the reservation environment, including geomorphology, geochemistry, soil physics, are included and discussed in the native language as much as possible — with their analogs in other planetary environments (such as Mars). The program began with a student defining 30 Navajo words to describe what he called 'NASA' words, such as: cell phone, astronaut, space suit, computer, and planets not visible to the naked eye. The use of NASA material and imagery have a positive impact on the accessibility of the overall STEM material but community involvement, and buy-in, is criti! cal to the success of the program. The US Rosetta Project modified its goals, and curriculum, to accommodate the programmatic desires of teachers in the district, and the capabilities of the medicine men that agreed to participate. In this presentation we will report on lessons learned, as well as metrics and successes associated with our most recent Summer Science Academy [2014].

  10. UNREALIZED COMPETITIONS OF THE 1920-1930ies IN THE CONTEXT OF THE ARCHITECTURE DEVELOPMENT PROCESS

    Directory of Open Access Journals (Sweden)

    Dudka Elena Nikolaevna

    2012-10-01

    Full Text Available Analysis of organizational and methodical issues associated with architectural competitions of the 1920-1930ss and evaluation of their results are provided in the article. The role of the architectural development and historical, cultural, social and ideological backgrounds of the architectural competitions are also covered by the author. The review of architectural competitions makes it possible to identify their impact produced on the development of the theory and practice of architecture. The period between 1920 and 1930 was marked by a quantitative and qualitative boom of architectural design competitions. Analysis of the practice of architectural competitions makes it possible to identify periods of revolutionary transformations. The most prominent buildings that date back to these periods include theatre buildings in Kharkov, Rostov-Don, Sverdlovsk; a competition for the architectural design of the Gosprom Building in Kharkov; a competition for the architectural design of the Palace of Soviets in Moscow, etc. These competitions have shaped up new approaches to volume and space-related solutions as well as architectural forms. Research of the integral process of development of approaches and/or methods of organization of architectural design competitions make it possible to identify their role as effective catalysts of architectural theory and practice.

  11. Planejamento e gestão estratégica nas IES comunitárias

    Directory of Open Access Journals (Sweden)

    Gissele Prette Heil

    2017-05-01

    Full Text Available Considering the complexity of University Management in the State and National levels, it is highlighted the importance of a well-designed and achievable Strategic Planning, whose actions allow the managers to act in accordance with the requirements that are presented on a daily basis. The article aims to analyze how the process of strategic management occurs in Citizenship Institutions of the ACAFE System. The specific objectives were divided in four stages, the first one approaches the Strategy, with the objective to analyze the process of organizational strategy, the second is related to the Strategic Thinking in order to identify if it has indicators of the existence of strategic thinking, together with the managers, the third stage will highlight the Strategic Planning, identifying if it is present and how it is elaborated and the fourth step, considering the previous steps, takes into consideration the actions arising from the possible existence of the previous requirements, as well as, gives the formulation and implementation of actions and how the monitoring and strategies control are carried out. It is understood that the topic addressed is of great relevance, since the Citizenship Institutions of Education, have generic and specific characteristics as well, which ends up in most cases making the strategic process very complex, difficult and not very effective. Increasingly, Higher Education Institutions need to formulate their strategies, adapting them to meet the latent demand, developing a process of competitive intelligence, allowing to deal more effectively with the competition, highlighting the competitive differential and value attributes perceived by the community where it is inserted. It is important to seek differentiation, the prominence, the necessary projection in the present times, so that they can survive and grow. Exploratory, descriptive and qualitative research was used for the present study. This research analyzed how the strategic management process is developed in the Citizenship Universities, allowing to infer and to identify where and how they are and to where they want go and they are able to proceed.

  12. Jihadist Cells and IED Capabilities in Europe: Assessing the Present and Future Threat to the West

    Science.gov (United States)

    2012-11-01

    177; and Casimiro García-Abadillo, 11-M: La venganza, Madrid, Spain: Esfera de los Libros , 2004, pp. 16-30. 86. Auto 10/04/06, pp. 132-141. 87. Auto 10...Esfera de los Libros , 2005, esp. chap. 3. Cf. also Serafín Fanjul, La quimera de Al-Andalus (The Al-Andalus Fantasy), Madrid, Spain: Siglo XXI...enigmas del 11-M: Conspiración o negligencia? (The Enigmas of 3/11: Conspira- cy or Negligence?), Madrid, Spain: Libros Libres, 2006, pp. 119-121. As the

  13. Reduced Kernel IE's for MEN Based Analysis of Multilayered FSS Structures

    NARCIS (Netherlands)

    Monni, S.; Neto, A.; Tijhuis, A.G.

    2006-01-01

    Despite the fact that the general behavior of periodic structures has been investigated for many decades, the analysis and design of multilayered FSS's is still a very actual and complicated problem. This is especially true for stringent requirements, which rise for example when the FSS has to be

  14. Vabaõhulavastuse "Jõujaam" proovid käivad täie hooga / Jan Rahman

    Index Scriptorium Estoniae

    Rahman, Jan, 1975-

    2007-01-01

    Leevaku hüdroelektrijaama juures etendub jaanipäeva paiku Jan Rahmani kirjutatud näitemäng "Jõujaam", lavastaja Raivo Adlas. Mängib Räpina näitemänguseltskond. Näitekirjanik tutvustab lavastust

  15. Schwinger-Dyson Equation in Minkowski Space beyond the IE Approximation

    CERN Document Server

    Sasagawa, Shuji

    2016-01-01

    We investigate properties of mass functions for fermion in Quantum Electrodynamics calculated by Schwinger-Dyson equation in strong coupling region. Numerical results for the mass functions in which one-loop integration is performed in Minkowski space. Calculated results without the instantaneous exchange approximation are compared with those obtained in Euclidean space.

  16. Vabaõhulavastuse "Jõujaam" proovid käivad täie hooga / Jan Rahman

    Index Scriptorium Estoniae

    Rahman, Jan, 1975-

    2007-01-01

    Leevaku hüdroelektrijaama juures etendub jaanipäeva paiku Jan Rahmani kirjutatud näitemäng "Jõujaam", lavastaja Raivo Adlas. Mängib Räpina näitemänguseltskond. Näitekirjanik tutvustab lavastust

  17. Self-adaptive road tracking in hyperspectral data for C-IED

    Science.gov (United States)

    Schilling, Hendrik; Gross, Wolfgang; Middelmann, Wolfgang

    2012-09-01

    For Counter Improvised Explosive Devices purposes, main routes including their vicinity are surveyed. In future military operations, small hyperspectral sensors will be used for ground covering reconnaissance, complementing images from infrared and high resolution sensors. They will be mounted on unmanned airborne vehicles and are used for on-line monitoring of convoy routes. Depending of the proximity to the road, different regions can be defined for threat assessment. Automatic road tracking can help choosing the correct areas of interest. Often, the exact discrimination between road and surroundings fails in conventional methods due to low contrast in pan-chromatic images at the road boundaries or occlusions. In this contribution, a novel real-time lock-on road tracking algorithm is introduced. It uses hyperspectral data and is specifically designed to address the afore- mentioned deficiencies of conventional methods. Local features are calculated from the high-resolution spectral signatures. They describe the similarity to the actual road cover and to either roadside. Classification is per- formed to discriminate the signatures. To improve robustness against variations in road cover, the classification results are used to progressively adapt the road and roadside classes. Occlusions are treated by predicting the course of the road and comparing the signatures in the target area to previously determined road cover signa- tures. The algorithm can be easily extended to show regions of varying threat, depending on the distance to the road. Thus, complex anomaly detectors and classification algorithms can be applied to a reduced data set. First experiments were performed for AISA Eagle II (400nm - 970nm) and AISA Hawk (970nm - 2450nm) data

  18. Traav Valge Maja poole jätkub täie hooga / Vello Pettai

    Index Scriptorium Estoniae

    Pettai, Vello, 1968-

    2008-01-01

    USA presidendivalimistel ei ole kindlaid kandidaate selgunud kummalgi parteil, ehkki eelvalimised on toimunud üle poolte osariikidest. Presidendikandidaadid Hillary Clinton, Barack Obama, John McCain ja Mike Huckabee

  19. EDUCAŢIE FORMALĂ, NONFORMALĂ ŞI INFORMALĂ: PERSPECTIVELE NOILOR EDUCAŢII

    Directory of Open Access Journals (Sweden)

    Carolina ŢURCANU

    2017-07-01

    Full Text Available În articol este abordată problema ce vizează noile educaţii în contextul educaţiei formale, nonformale şi informale. Accentul se pune pe analiza tendinţelor pe plan internaţional şi naţional în vederea valorificării mai eficiente a noilor educaţii în condiţiile schimbării potenţialului formativ al educaţiei formale spre educaţia nonformală şi informală.FORMAL, NON-FORMAL AND INFORMAL EDUCATION: NEW PERSPECTIVES OF EDUCATIONThe approach of the article is the problem of new educations in context of formal, non-formal and informal educations. The focus is on the analysis of trends on national and international level, in order to exploit more effectively the new educations in changing conditions of the formative potential of the formal to non-formal and informal educations.

  20. Determination of Thorium i.e 23 Trace Elements in UF4

    Institute of Scientific and Technical Information of China (English)

    WANG; Ling; ZHANG; Qian-ci; LIU; Gui-jiao; ZHAO; Li-fei

    2015-01-01

    UF4is the final product of uranium refining,and also is the semifinished product during the production of uranium metal and UF6.Demands of UF4are growing gradually as the rapid development of nuclear power.Due to the marginal purification during the translation of UF4 to

  1. Schengen Facility hankeprojektid on täies hoos / Helena Loorents

    Index Scriptorium Estoniae

    Loorents, Helena

    2005-01-01

    Schengen Facility toetusest uutele EL-i liikmesriikidele. Schengen Facility programmi vahenditest toetatakse Eesti piirivalvele RIB C-1100 tüüpi paatide ning piirivalvekopter hankimist, valminud on uus merevalvekeskus

  2. Evaluating the protection levels of armoured vehicles for KE, mine and IED threats

    NARCIS (Netherlands)

    Verhoeven, T.A.

    2010-01-01

    Based on providing protection to the occupants of armoured vehicles a NATO standard is under implementation (STANAG 4569). The aim of this agreement is to standardize protection levels for armoured vehicle occupants to ensure that: a. Commanders in the field can select the right equipment to fulfil

  3. PRINCIPII ALE ADMINISTRAŢIEI DESPRINSE DIN TRATATUL INSTITUIND O CONSTITUŢIE PENTRU EUROPA

    Directory of Open Access Journals (Sweden)

    Gina Livioara Chiric

    2006-05-01

    Full Text Available Constitutional traditions of the Member States are an important element in the construction of a European Administrative Law. Various principles can be deduced from the Treaty establishing a Constitution for Europe as constituting general principles of administrative action in Europe. In the same time, the Constitution recalls the dissimilarities existing in the Member States between legislative and implementing (or executing functions. The Treaty establishing a Constitution for Europe stipulates some principles that are applicable for administrative action. In most cases these principles are addressed to the Union Institutions, in others they are directly applicable in Member States’ action.

  4. 参加IE C执委会(C A)会议简况

    Institute of Scientific and Technical Information of China (English)

    温珊林

    2001-01-01

    @@ IEC第111次CA会议于2001年6月14日至15日在日内瓦召开.来自14个成员国家委员会的24名代表,以及CENELEC、ISO、ITU、IEEE的代表出席了会议.会议由CA主席Mr.D.Deno-ble主持.会议议题共12项,会议主要有以下内容:

  5. Pictures of Industry and Industrial Work in Danish Art from the 1780ies till Today

    DEFF Research Database (Denmark)

    Abildgaard, Hanne

    2013-01-01

    Artiklen diskuterer, hvilke spor industrisamfundet har sat sig i dansk kunst gennem mere end 200 år. Den fokuserer på kunstnere, der bevidst har forholdt sig til industrisamfundets fænomener, og polemiserer i forlængelse heraf mod den opfattelse, at industrien er næsten totalt fraværende i dansk ...

  6. Diet of the cyprinid fish Barbus aeneus (Burchell) in the P .K. Ie Roux ...

    African Journals Online (AJOL)

    length and mass of the fIsh were measured to the nearest 1 mm and 0,1 g respectively. ... 2 h, the deep-water fIsh were considered only in the qualitative .... changes in diet were minimized by recording the contents of each section of the gut .... S. AfT. J. Zoo!. 1986,21(3). 261. Table 2 Relative importance of factors in multiple ...

  7. "Uinuv kaunitar" tuleb Jõhvi täies hiilguses / Irina Kiviselg

    Index Scriptorium Estoniae

    Kiviselg, Irina, 1961-

    2009-01-01

    Jõhvis balletifestivalil saab näha 6.-7. veebr. 2009 vene klassikalist balletti "Uinuv kaunitar". Peaosades Jevgeni Ivantšenko ja Irina Golub Peterburi Maria teatrist ning Londoni teatri solistid Age Oks ja Toomas Edur

  8. Physics of IED blast shock tube simulations for mTBI research

    NARCIS (Netherlands)

    Mediavilla Varas, J.; Philippens, M.M.G.M.; Meijer, S.R.; Berg, A.C. van den; Sibma, P.C.; Bree, J.L.M.J. van; Vries, D.V.W.M. de

    2011-01-01

    Shock tube experiments and simulations are conducted with a spherical gelatin filled skull- brain surrogate, in order to study the mechanisms leading to blast induced mild traumatic brain injury. A shock tube including sensor system is optimized to simulate realistic impro-vised explosive device bla

  9. Physics of IED Blast Shock Tube Simulations for mTBI Research.

    Science.gov (United States)

    Mediavilla Varas, Jesus; Philippens, M; Meijer, S R; van den Berg, A C; Sibma, P C; van Bree, J L M J; de Vries, D V W M

    2011-01-01

    Shock tube experiments and simulations are conducted with a spherical gelatin filled skull-brain surrogate, in order to study the mechanisms leading to blast induced mild traumatic brain injury. A shock tube including sensor system is optimized to simulate realistic improvised explosive device blast profiles obtained from full scale field tests. The response of the skull-brain surrogate is monitored using pressure and strain measurements. Fluid-structure interaction is modeled using a combination of computational fluid dynamics (CFD) simulations for the air blast, and a finite element model for the structural response. The results help to understand the physics of wave propagation, from air blast into the skull-brain. The presence of openings on the skull and its orientation does have a strong effect on the internal pressure. A parameter study reveals that when there is an opening in the skull, the skull gives little protection and the internal pressure is fairly independent on the skull stiffness; the gelatin shear stiffness has little effect on the internal pressure. Simulations show that the presence of pressure sensors in the gelatin hardly disturbs the pressure field.

  10. Distribution and mechanism of Type I-E CRISPR-Cas systems

    NARCIS (Netherlands)

    Staals, R.H.J.; Brouns, S.J.J.

    2013-01-01

    Although the CRISPR type I system encompasses six different subtypes (I-A to I-F), only three subtypes have been studied in detail to date. This review includes an analysis of the distribution of CRISPR-Cas systems among the different bacterial and archaeal lineages, and will focus on our mechanisti

  11. Novel Task Functionalized Biopolymers for Enhanced Change Detection in Support of C-IED Operations

    Science.gov (United States)

    2013-04-15

    produced by a soil bacterial species, Rhizobium tropici(RTEPS) and 3) polyacrylamide, a synthetic polymer that is considered the standard for soil...Franzén, L.-E., Darvill, J.E., McNeil, M., Darvill, A.G., Albersheim, P., 1983a. The structure of the acidic polysaccharide secreted by Rhizobium ...Bulletin 128991. ----- 1983b. The structure of the acidic polysaccharide secreted by Rhizobium phaseoli Strain 127 K87. Carbohydr. Res. 117, 169-183

  12. On improving IED object detection by exploiting scene geometry using stereo processing

    Science.gov (United States)

    van de Wouw, Dennis W. J. M.; Dubbelman, Gijs; de With, Peter H. N.

    2015-03-01

    Detecting changes in the environment with respect to an earlier data acquisition is important for several applications, such as finding Improvised Explosive Devices (IEDs). We explore and evaluate the benefit of depth sensing in the context of automatic change detection, where an existing monocular system is extended with a second camera in a fixed stereo setup. We then propose an alternative frame registration that exploits scene geometry, in particular the ground plane. Furthermore, change characterization is applied to localized depth maps to distinguish between 3D physical changes and shadows, which solves one of the main challenges of a monocular system. The proposed system is evaluated on real-world acquisitions, containing geo-tagged test objects of 18 18 9 cm up to a distance of 60 meters. The proposed extensions lead to a significant reduction of the false-alarm rate by a factor of 3, while simultaneously improving the detection score with 5%.

  13. CURTEA DE CONTURI EUROPEANĂ INSTITUŢIE DE AUDIT EXTERN A UNIUNII EUROPENE

    Directory of Open Access Journals (Sweden)

    Ecaterina Necsulescu

    2008-05-01

    Full Text Available En vue d’assurer la responsabilité à l’égard de la modalité d’utilisation des fonds publics,dans toute société démocratique moderne, la fonction d’audit externe est essentielle.La Cour des comptes européenne est l’institution d’audit externe de l’Union européenne qui, par sacontribution à l’amélioration de tous les aspects relatifs à la gestion financière des fonds de l’Unioneuropéenne, a un rôle essentiel pour les citoyens de l’Union.La mission de la Cour, dans sa qualité d’auditeur externe, est d’évaluer la gestion financière du budgeten ensemble, de contrôler l’exécution du budget général de l’Union européenne et des Fonds européens dedéveloppement et aussi les comptes de tous les organismes et agents de l’Union européenne.En conformité avec ses propres politiques et standards d’audit, la Cour des comptes européenneeffectue l’activité d’audit indépendamment des autres institutions de l’Union européennes et des états membres.

  14. Hiiglasliku uinunud Buddha kuju otsing jätkub täie hooga / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Afganistani arheoloog Zemarzyali Tarzi leidis 19-meetrise lamava Buddha kuju. Arheoloog tahab taastada Talibani poolt hävitatud 38 ja 55 meetrit kõrged Buddha kujud, mis olid püstitatud 6. sajandil

  15. Pro Internet Explorer 8 & 9 Development Developing Powerful Applications for the Next Generation of IE

    CERN Document Server

    Crowley, Matthew

    2010-01-01

    This book is an in-depth guide to writing applications that embrace and extend the new features and capabilities of Windows Internet Explorer 8 and 9. With solid instruction, hands-on examples, and expert insight direct from the source into extending the browser, you'll learn how to create and maintain powerful applications for Microsoft's next-generation Internet platform. Join author Matthew Crowley as you discover how to take advantage of new features like accelerators, WebSlices, and search providers, and create intense web experiences for the browser that ships by default with the popular

  16. Evaluation of screening programmes: Stud ies on breast cancer and prostate cancer

    NARCIS (Netherlands)

    P.M.M. Beemsterboer (Petra)

    1999-01-01

    textabstractIn the past century treatment and primary prevention of disease has focussed on decreasing mortality rates (Wolleswinkel-van den Bosch, 1998). The current challenge is directed towards secondary prevention. Screening for disease is becoming increasingly part of medical practice in the We

  17. Data Protection Control and Learning Conducted Via Electronic Media I.E. Internet

    Directory of Open Access Journals (Sweden)

    Mohamed F. AlAjmi

    2014-11-01

    Full Text Available numerous e-taking in establishments are hurrying into receiving ICT without precisely arranging and seeing any related security concerns. E-learning is another technique for taking in which eventually relies on upon the Internet in its execution. The Internet has turned into the venue for another set of unlawful exercises, and the e-taking in environment is notwithstanding laid open to such dangers. In this paper, e-learning setting, definition, aspects, improvement, development, profits and tests are all explained upon. This paper examines the security components needed to be executed inside e-learning situations. Moreover, the paper clarifies the circumstances and existing examination relating to security in e-taking in. Besides, data security administration is inferred to help setting up a secured e-taking nature's turf.

  18. El ALCA y la Ubicación de la IED

    OpenAIRE

    Eduardo Levy Yeyati; Ernesto H. Stein; Christian Daude

    2003-01-01

    Durante las últimas décadas, hemos evidenciado un incremento en el número y la profundidad de los acuerdos de integración regionales (AIR) alrededor del mundo. La proliferación de acuerdos comerciales ha sido considerablemente amplia. La antigua Comunidad Económica Europea evolucionó hacia un único mercado (UE) y la mayoría de sus miembros recientemente han adoptado una moneda común. Otros países europeos han conformado áreas de libre comercio con la UE o se encuentran actualmente en espera p...

  19. Data of evolutionary structure change: 1IE3A-2LDXC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 25.046 -0.572 70.944 1.00 21.30 C -map> VAL GLY PRO THR VAL PRO A.../line> VAL CA -map> TYR CA 422 ASP CA 366 ILE ... 5466 CA GLU C 60 7.269 22.529 -7.116 1.00 13.76 C ...ne>GLY CA 3.80 GLU CA ce-map> VAL CA 442 ASP CA 374 -map> ILE LYS VAL ALA THR PRO ILE HIS SER LEU

  20. Improving Situational Awareness in the Counter-IED Fight with the Utilization of Unmanned Sensor Systems

    Science.gov (United States)

    2009-06-01

    tactics, techniques, and procedures UAS unmanned aircraft system UFO /E ultra-high frequency follow-on enhanced UFO /EE UHF follow-on EHF enhanced...communication (SATCOM) package (FEP), Ultra-high Frequency Follow-on Enhanced ( UFO /E), the UHF Follow-on EHF Enhanced ( UFO /EE), Polar EHF Package (PEP), and

  1. Quntitative [i.e. Quantitative] analysis of risky decision making in economic environments

    OpenAIRE

    Andraszewicz, Sandra

    2014-01-01

    Risky economic decisions play an important role in everyone's life. This dissertation presents mathematical approaches to the analysis of these decisions. It discusses how statistical measures can describe properties of choice options, and how these properties can be used to describe the decision context. Also, this dissertation includes a practical tutorial on a Bayesian approach to the hierarchical regression analysis in management science. Therefore, the combined dissertation presents math...

  2. The Optimal Taxation of UnskilIed Labor with Job Search and Social Assistance

    NARCIS (Netherlands)

    Boone, J.; Bovenberg, A.L.

    2002-01-01

    In order to explore the optimal taxation of low-skilled labor, we extend the standard model of optimal non-linear income taxation in the presence of quasi-linear preferences in leisure by allowing for involuntary unemployment, job search, an exogenous welfare benefit, and a non-utilitarian social we

  3. Arstidest - mitte nende tööst / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie, 1934-

    2011-01-01

    Režissöör-lavastaja Igor Jeltsovi viimasest filmist "Null kolm" (1964), tagasivaade tema loomingule. Peaosades: Ninel Mõškova, Ivan Dmitrijev, Tatjana Peltser, Jevgeni Teterin. Filmi näeb ETV2 sarjas "Unustatud filmid"

  4. Physical Education Initial Teacher Educators' Expressions of Critical Pedagogy(ies): Coherency, Complexity or Confusion?

    Science.gov (United States)

    Philpot, Rod

    2016-01-01

    While an emphasis on social justice has emerged as a theme in initial teacher education (ITE) over the past decade, there is much debate about how to engage ITE students in foregrounding issues of equity and social justice in their own teaching. One strategy, the introduction of critical pedagogy in ITE, has been promoted in teacher education…

  5. I-E Scores of Drug-Abusing Offenders: The Influence of Social Desirability.

    Science.gov (United States)

    McBridge, Kevin J.

    1982-01-01

    Tests the relationship between locus of control and drug abuse and the influence of test instructions and social desirability. Results of research with incarcerated offenders indicated test instructions aimed at heightening social desirability artificially inflated locus of control scores. Found no significant differences between drug abusers and…

  6. Ämaris asuvad hävitajad lendavad täies relvis

    Index Scriptorium Estoniae

    2016-01-01

    Ämari õhubaasis asuvad Saksa õhujõudude hävitajad Eurofighter Typhoon on Ukraina konflikti tõttu varustatud täieliku lahingrelvastusega, hävitajatel on lühi-ja keskmaaraketid, kirjutab Spiegel

  7. On the Agenda: Changing Nurses' Careers in 1999. IES Report 360.

    Science.gov (United States)

    Robinson, Dilys; Buchan, James; Hayday, Sue

    A survey of a random sample of 6,000 registered nurses who were members of the Royal College of Nursing explored views on issues related to working as a nurse and having a career in nursing. Recent policy documents highlighted the high value the government placed on the role of nurses. Results indicated there were clear gender differences with…

  8. Evaluation of screening programmes: Stud ies on breast cancer and prostate cancer

    NARCIS (Netherlands)

    P.M.M. Beemsterboer (Petra)

    1999-01-01

    textabstractIn the past century treatment and primary prevention of disease has focussed on decreasing mortality rates (Wolleswinkel-van den Bosch, 1998). The current challenge is directed towards secondary prevention. Screening for disease is becoming increasingly part of medical practice in the

  9. Improving Adolescent Literacy: Effective Classroom and Intervention Practices. IES Practice Guide. NCEE 2008-4027

    Science.gov (United States)

    Kamil, Michael L.; Borman, Geoffrey D.; Dole, Janice; Kral, Cathleen C.; Salinger, Terry; Torgesen, Joseph

    2008-01-01

    The goal of this practice guide is to formulate specific and coherent evidence-based recommendations that educators can use to improve literacy levels among adolescents in upper elementary, middle, and high schools. The target audience is teachers and other school personnel with direct contact with students, such as coaches, counselors, and…

  10. Aardekütid varastasid eesti rahva ajaloost suure suutäie / Tiiu Põld

    Index Scriptorium Estoniae

    Põld, Tiiu, 1945-

    2008-01-01

    Rae valla Salu küla ajaloolises Ubina asulas 2005. a. toime pandud aardevargusest. Kommenteerivad Ajaloo Instituudi mündikogu hoidja Mauri Kiudsoo, Ajaloomuuseumi teadusdirektor Ivar Leimus ja Muinsuskaitseameti arheoloogiamälestiste peainspektor Ants Kraut

  11. Evaluation of screening programmes: Stud ies on breast cancer and prostate cancer

    OpenAIRE

    Beemsterboer, Petra

    1999-01-01

    textabstractIn the past century treatment and primary prevention of disease has focussed on decreasing mortality rates (Wolleswinkel-van den Bosch, 1998). The current challenge is directed towards secondary prevention. Screening for disease is becoming increasingly part of medical practice in the Western world. Screening for cervical cancer with PAP smears and for lung cancer with chest X-rays were the first examples of cancer screening that were expected to reduce mortality (Boucot, 1948; Pa...

  12. Deterring the Dragon: Air-Sea BattIe and the U.S.-Japan Alliance

    Science.gov (United States)

    2011-06-17

    43  CHAPTER 3 AIR-SEA BATTLE: BRIDGING THE ‘ MYOPIA ’ GAP...marked change in strategic thought and serves as a significant milestone is breaking the “operational myopia ” that has influenced the United States since...1 Central Intelligence Agency, “The World Factbook,” http://www.cia.gov/library/publications/the-world

  13. Arstidest - mitte nende tööst / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie, 1934-

    2011-01-01

    Režissöör-lavastaja Igor Jeltsovi viimasest filmist "Null kolm" (1964), tagasivaade tema loomingule. Peaosades: Ninel Mõškova, Ivan Dmitrijev, Tatjana Peltser, Jevgeni Teterin. Filmi näeb ETV2 sarjas "Unustatud filmid"

  14. Euroveokid soosivad Venemaal käies üha enam Via Hanseaticat / Madis Aesma

    Index Scriptorium Estoniae

    Aesma, Madis

    2005-01-01

    Ajal. Postimees lüh. Pärast Balti riikide ühinemist Euroopa Liiduga kasutavad välismaa veoautojuhid üha enam Euroopast Venemaale sõitmiseks Valga-Tartu-Jõhvi-Narva maanteed, mis moodustab Via Hanseatica ehk Hansatee Eesti osa. Lisa: Via Hanseatica. Kaart: Visa Hanseatica

  15. s van ver- uiwering digende ie van 'n stallasies 'n modu- iese mor ...

    African Journals Online (AJOL)

    2006-01-27

    Jan 27, 2006 ... Visual culture studies suggest a shift from a focus on ... looked at or to enhance natural vision, from oil painting to ... into account the effects of globalization on. South African .... Stellenbosch: SUN ePReSS. 2005. 97 pp.

  16. Distributed Constrained Optimization over Constrained Communication Topologies. Technical Report IES-2014-07

    OpenAIRE

    Pfrommer, Julius

    2015-01-01

    The Max-Sum algorithm, an instance of the Generalized Distributive Law family, is known to solve Distributed Constraint Optimization Problems (DCOP) where the summed utility functions of interacting agents are maximized. However, Max-Sum relies on available communication channels between all agents that partake in a utility function. We present a generalization of Max-Sum that solves DCOP exactly in situations where the communication network layout does not match the agents' utility inter-dep...

  17. Mapping An Internal-External (I-E) Matrix Using Traditional And Extended Matrix Concepts

    National Research Council Canada - National Science Library

    Christopher M. Cassidy; Michael D. Glissmeyer; Charles J. Capps III

    2013-01-01

      Internal Factor Evaluation (IFE) and External Factor Evaluation (EFE) matrices allow an organization to visualize their strengths, weaknesses, opportunities and threats while a Competitive Profile Matrix (CPM...

  18. Standard laboratory hydraulic pressure drop characteristics of various solid and I&E fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Waters, E.D.; Horn, G.R.

    1958-01-20

    The purpose of this report is to present a set of standard pressure-drop curves for various fuel elements in process tubes of Hanford reactors. The flow and pressures within a process tube assembly under normal conditions are dependent to a large extent on the magnitude of the pressure drop across the fuel elements. The knowledge of this pressure drop is important in determination of existing thermal conditions within the process tubes and in predicting conditions for new fuel element designs or changes in operating conditions. The pressure-flow relations for the different Hanford fuel element-process tube assemblies have all been determined at one time or another in the 189-D Hydraulics Laboratory but the data had never been collected into a single report. Such a report is presented now in the interest of establishing a set of ``standard curves`` as determined by laboratory investigations. It must be recognized that the pressure drops of fuel elements in actual process tubes in the reactors may be slightly different than those reported here. The data presented here were obtained in new process tubes while reactor process tubes are usually either corroded or filmed, depending on their past history.

  19. Vers une meilleure comprehension des savoirs disciplinaires et curriculaires des enseignants ou Ie paradigme retrouve

    Directory of Open Access Journals (Sweden)

    Stephane Martineau

    1999-01-01

    Full Text Available eet article se veut essentieUement un travail de synthese sous la forme d 'une breve revue de litterature au sujet des savoirs disciplinaires et curriculaires en enseignement. Plus specifiquement, il vise a determiner queUes sont les principales conclusions qui se degagent de la lecture des recherches empiriques sur les savoirs disciplinaires et curriculaires des enseignants des ordres d'enseignement primaire et secondaire. Il propose donc une classification des differentes dimensions constitutives du rapport entre les savoirs disciplinaires et curriculaires et la pratique enseignante. Les resultats mis au jour permettent d 'une part, d'identifier les facteurs qui entrainent des differences dans les connaissances disciplinaires et curriculaires des enseignants et d'autre part, de mieux saisir comment ces connaissances de l'enseignant peuvent influencer en retour sa pratique.

  20. Moesügis õilmitseb täies jõus

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna Kristiine keskuse moepäevade raames toimub Moeturg. Oma loomingut näitavad õed Laugased, Kriss Soonik, Maria Tennof ja teised eesti noorte disainerite paremikust. Üle 40 noore disaineri müüb oma toodangut

  1. Euroveokid soosivad Venemaal käies üha enam Via Hanseaticat / Madis Aesma

    Index Scriptorium Estoniae

    Aesma, Madis

    2005-01-01

    Ajal. Postimees lüh. Pärast Balti riikide ühinemist Euroopa Liiduga kasutavad välismaa veoautojuhid üha enam Euroopast Venemaale sõitmiseks Valga-Tartu-Jõhvi-Narva maanteed, mis moodustab Via Hanseatica ehk Hansatee Eesti osa. Lisa: Via Hanseatica. Kaart: Visa Hanseatica

  2. Physical Education Initial Teacher Educators' Expressions of Critical Pedagogy(ies): Coherency, Complexity or Confusion?

    Science.gov (United States)

    Philpot, Rod

    2016-01-01

    While an emphasis on social justice has emerged as a theme in initial teacher education (ITE) over the past decade, there is much debate about how to engage ITE students in foregrounding issues of equity and social justice in their own teaching. One strategy, the introduction of critical pedagogy in ITE, has been promoted in teacher education…

  3. Different Records of Manuchehri’s Six Odes (i.e. Qasidahs in Three Old Sources

    Directory of Open Access Journals (Sweden)

    علی اشرف صادقی

    2013-06-01

    Full Text Available Manuscripts of Manuchehri’s divan are relatively new. Only one manuscript dates back to 1051 A.H. Scribes have systematically “modernized” the older records. To have access to the poet’s language, one must either refer to the old manuscripts which are still unknown or else resort to literary miscellanies containing the poet’s poems. The author has presented here a number of different and rather older records of the poet’s six odes from three old sources.

  4. Interspecies Quorum Sensing as a Stress-Anticipation Signal in <i>E. coli

    DEFF Research Database (Denmark)

    Høyland-Kroghsbo, Nina Molin

    behavior genes. Quorum sensing controls important bacterial behaviors, including bioluminescence, biofilm formation, and virulence. Inter- and intraspecies quorum sensing signals enable bacteria to estimate the abundance and species complexity of a microbial community. A long standing question...

  5. 复制传统——2005 MOTO GUZZI Breva V1100IE

    Institute of Scientific and Technical Information of China (English)

    标准烈日

    2005-01-01

    在这个冰冷的机车世界里,没有多少品牌能像摩托·古兹那样赢得人们的同情和好感,因为它对传统的坚持令人感动。独特的横置V型双缸发动机成为一个符号,一个关于经典的符号。无数车迷成为这一传统的追随者。在去年的杂志中.我们曾介绍过摩托·古兹的Brava V7501E.这是摩托·古兹在两年前的慕尼黑车展中发表的新车系。由于市场的良好反响,2005年.摩托·古兹将版本升级为最新的1100毫升的Breva V1100IE.使其成为该系列中的旗舰车型。

  6. Kirkpatrick and Beyond: A Review of Models of Training Evaluation. IES Report.

    Science.gov (United States)

    Tamkin, P.; Yarnall, J.; Kerrin, M.

    Many organizations are not satisfied that their methods of evaluating training are rigorous or extensive enough to answer questions of value to them. Complaints about Kirkpatrick's popular four-step model (1959) of training evaluation are that each level is assumed to be associated with the previous and next levels and that the model is too simple…

  7. EVOLUŢIA ISTORICĂ A MENTORATULUI ÎN EDUCAŢIE

    Directory of Open Access Journals (Sweden)

    Tatiana BALAN

    2015-12-01

    Full Text Available În articol este realizată o examinare a semnificaţiilor istorice ale conceptelor mentor, discipol şi mentorat. Valoarea epistemologică a termenilor a contribuit la preluarea metodelor incipiente ale mentoratului şi la adaptarea lor la practi-cile de dezvoltare a umanităţii pe parcursul evoluţiei istoriei. Autorul identifică semnificaţia aplicării activităţilor de mentorat în mai multe state ale lumii şi abordează acest subiect în noile politici educaţionale ale Republicii Moldova.THE HISTORICAL EVOLUTION OF MENTORING IN EDUCATIONThe content of article represents an examination of historical meanings of the concepts: mentor, disciple and mentoring. The epistemological value of terms contributes to taking over the incipient mentoring methods and their adaptation to humanity development during of historical evolution. The author identifies the impact of applying of mentoring activities in many countries as well as approaching of this subject in up-to-date educational politics of the Republic of Moldova.

  8. El sistema de evaluación de las IES en México

    Directory of Open Access Journals (Sweden)

    Giovanna Valenti

    1997-01-01

    Full Text Available Este artículo nos presenta como desde finales de los años ochenta existe una profunda preocupación de investigadores, gobierno y opinión pública por mejorar la calidad de la educación superior en nuestro país. De esta manera, se han planteado una serie de mecanismos para evaluar los objetivos y los resultados de las instituciones educativas; de tal suerte, la ampliación en la asignación de recursos se encuentra estrechamente vinculada con el desarrollo de estos procesos

  9. La Reforma Educativa en México. ¿Nuevas reglas para las IES ?

    OpenAIRE

    Pedro Flores Crespo; César García García

    2014-01-01

    ¿Por qué debe preocupar la Reforma Educativa, centrada en la evaluación y en los sistemas de educación básico y media superior, a las Instituciones de Educación Superior mexicanas? Basándose en un marco teórico del nuevo institucionalismo (North, 1994; Helmke y Levitsky, 2004; Schmidt, 2010) y tomando en cuenta los aportes en este campo por autores mexicanos (Acosta, 2014; Ordorika, 2014), el presente trabajo responde a esta pregunta argumentando que hay tres razones principales para que las ...

  10. INVESTIGAREA CRIMINALISTICĂ A LOCULUI FAPTEI IN CAZUL INFRACŢIUNILOR DE CORUPŢIE

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2007-05-01

    Full Text Available In this work,I’ve presented the meaning of corruption offences,which is corruption sense for romanian state.The criminalistica investigation will be done,regularity,at the beginning of penal pursuance,for knowledge ofoffences accomplishment.Also,we can tell this activity is expanding,distinctive, during the examination ofcriminal place.Should be discussed the following thing:if in most cases of offences,such manslaughter,theexamination of criminal place is often realized for identify offender,but when we speak about the corruptionoffences,the criminalistica investigation has hinted at offender for establish the action.The romanian penal law is anticipate some substantial and formal conditions looking for the criminalisticainvestigation.As regards this examination,are taken preparatory measures at the judicial offices,and also,at thecriminal place;the examination team are organized with suitable technical and scientific means.In accordance with nature of facts,commited place,or after-effects,these teams are includedprosecutors,criminalist,officer of judicial police,experts from technical area,but the activity sovereign is theprosecutor.Also,the assistant witness has an important role in this activity,and he hadn’t any involve in respectivecause.Finally,the issues of investigation are materialized and described in a record.

  11. ANSI/ASHRAE/IES Standard 90.1-2010 Final Determination Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Liu, Bing

    2011-10-31

    The U.S. Department of Energy (DOE) conducted a final quantitative analysis to assess whether buildings constructed according to the requirements of the American National Standards Institute (ANSI)/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010 (ASHRAE Standard 90.1-2010, Standard 90.1-2010, or 2010 edition) would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IESNA Standard 90.1-2007(ASHRAE Standard 90.1-2007, Standard 90.1-2007, or 2007 edition). The final analysis considered each of the 109 addenda to ASHRAE Standard 90.1-2007 that were included in ASHRAE Standard 90.1-2010. All 109 addenda processed by ASHRAE in the creation of Standard 90.1-2010 from Standard 90.1-2007 were reviewed by DOE, and their combined impact on a suite of 16 building prototype models in 15 ASHRAE climate zones was considered. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE's final determination. However, out of the 109 addenda, 34 were preliminarily determined to have a measureable and quantifiable impact. A suite of 240 computer energy simulations for building prototypes complying with ASHRAE 90.1-2007 was developed. These prototypes were then modified in accordance with these 34 addenda to create a second suite of corresponding building simulations reflecting the same buildings compliant with Standard 90.1-2010. The building simulations were conducted using the DOE EnergyPlus building simulation software. The resulting energy use from the complete suite of 480 simulation runs was then converted to energy use intensity (EUI, or energy use per unit floor area) metrics (Site EUI, Primary EUI, and energy cost intensity [ECI]) results for each simulation. For each edition of the standard, these EUIs were then aggregated to a national basis for each prototype using weighting factors based on construction floor area developed for each of the 15 U.S. climate zones using commercial construction data. When compared, the resulting weighted EUIs indicated that each of the 16 building prototypes used less energy under Standard 90.1-2010 than under Standard 90.1-2007 on a national basis when considering site energy, primary energy, or energy cost. The EUIs were also aggregated across building types to a national commercial building basis using the same weighting data. On a national basis, the final quantitative analysis estimated a floor-space-weighted national average reduction in new building energy consumption of 18.2 percent for source energy and 18.5 percent when considering site energy. An 18.2 percent savings in energy cost, based on national average commercial energy costs for electricity and natural gas, was also estimated.

  12. Improving Reading Comprehension in Kindergarten through 3rd Grade: IES Practice Guide. NCEE 2010-4038

    Science.gov (United States)

    Shanahan, Timothy; Callison, Kim; Carriere, Christine; Duke, Nell K.; Pearson, P. David; Schatschneider, Christopher; Torgesen, Joseph

    2010-01-01

    Strong reading comprehension skills are central not only to academic and professional success, but also to a productive social and civic life. These skills build the capacity to learn independently, to absorb information on a variety of topics, to enjoy reading, and to experience literature more deeply. Despite the growing demand for highly…

  13. Detection and characterization of spacer integration intermediates in type I-E CRISPR–Cas system

    Science.gov (United States)

    Arslan, Zihni; Hermanns, Veronica; Wurm, Reinhild; Wagner, Rolf; Pul, Ümit

    2014-01-01

    The adaptation against foreign nucleic acids by the CRISPR–Cas system (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins) depends on the insertion of foreign nucleic acid-derived sequences into the CRISPR array as novel spacers by still unknown mechanism. We identified and characterized in Escherichia coli intermediate states of spacer integration and mapped the integration site at the chromosomal CRISPR array in vivo. The results show that the insertion of new spacers occurs by site-specific nicking at both strands of the leader proximal repeat in a staggered way and is accompanied by joining of the resulting 5′-ends of the repeat strands with the 3′-ends of the incoming spacer. This concerted cleavage-ligation reaction depends on the metal-binding center of Cas1 protein and requires the presence of Cas2. By acquisition assays using plasmid-located CRISPR array with mutated repeat sequences, we demonstrate that the primary sequence of the first repeat is crucial for cleavage of the CRISPR array and the ligation of new spacer DNA. PMID:24920831

  14. (Multiletramento(s digital(is e teoria do posicionamento: análise das práticas discursivas de professoras que se relacionaram com as tecnologias da informação e comunicação no ensino público Digital (multiliteracy(ies and positioning theory: analysis of discursive practices of teachers involved with information and communication technologies in the public education

    Directory of Open Access Journals (Sweden)

    Fabiano Santos Saito

    2012-01-01

    ítica e questionadora desses contextos educacionais, considerando a formação docente como essencial para a apropriação e o uso situado das TICs. Também é nosso intento levantar discussões transdisciplinares nas áreas de Linguística, Ensino e Tecnologia.The aim of this work is to analyze the discursive practices of three teachers involved both direct and indirectly with Information and Communication Technologies (ICTs in the teaching-learning process of a public school situated in the city of Juiz de Fora - State of Minas Gerais in Brazil. To accomplish our goal, we used the theoretical model of Digital Multiliteracies (SELBER, 2004, regarding the uses and social practices of Digital Era. To enrich the analyses of this study, we also brought the theoretical contributions of Positioning Theory (HARRÉ; VAN LANGENHOVE, 1999, in order to understand how teachers take positions within a teaching context that uses digital technologies. This is a qualitative-interpretivist research methodologically set as ethnographic case study allied to a discourse analysis. The results points that, although in a first moment all the teachers take a technophile position (i.e., a position in favor of use of ICTs in educational environment, this position is rejected by some teachers indirectly involved with Computer Lab in later positionings (discursive positions takings, in which it is possible to identify technophobic positions (fear or resistance to digital technologies, that are indices of lack of teacher training oriented for more effective and situated use of ICTs in classrooms. Furthermore, the positions and positionings taken by teachers indicate a Functional Digital Literacy model in the school investigated, which is motivated by informational infrastructure troubles and institutional forces from social instances above the school. One of theoretic-methodological contributions of this study is to relate the Position Theory to the model of Digital Multiliteracies to explain the

  15. (Multiletramento(s digital(is e teoria do posicionamento: análise das práticas discursivas de professoras que se relacionaram com as tecnologias da informação e comunicação no ensino público Digital (multiliteracy(ies and positioning theory: analysis of discursive practices of teachers involved with information and communication technologies in the public education

    Directory of Open Access Journals (Sweden)

    Fabiano Santos Saito

    2013-03-01

    ítica e questionadora desses contextos educacionais, considerando a formação docente como essencial para a apropriação e o uso situado das TICs. Também é nosso intento levantar discussões transdisciplinares nas áreas de Linguística, Ensino e Tecnologia.The aim of this work is to analyze the discursive practices of three teachers involved both direct and indirectly with Information and Communication Technologies (ICTs in the teaching-learning process of a public school situated in the city of Juiz de Fora - State of Minas Gerais in Brazil. To accomplish our goal, we used the theoretical model of Digital Multiliteracies (SELBER, 2004, regarding the uses and social practices of Digital Era. To enrich the analyses of this study, we also brought the theoretical contributions of Positioning Theory (HARRÉ; VAN LANGENHOVE, 1999, in order to understand how teachers take positions within a teaching context that uses digital technologies. This is a qualitative-interpretivist research methodologically set as ethnographic case study allied to a discourse analysis. The results points that, although in a first moment all the teachers take a technophile position (i.e., a position in favor of use of ICTs in educational environment, this position is rejected by some teachers indirectly involved with Computer Lab in later positionings (discursive positions takings, in which it is possible to identify technophobic positions (fear or resistance to digital technologies, that are indices of lack of teacher training oriented for more effective and situated use of ICTs in classrooms. Furthermore, the positions and positionings taken by teachers indicate a Functional Digital Literacy model in the school investigated, which is motivated by informational infrastructure troubles and institutional forces from social instances above the school. One of theoretic-methodological contributions of this study is to relate the Position Theory to the model of Digital Multiliteracies to explain the

  16. NBA 马刺队整体进攻基本战术原则研究%Study of Basic TacticaI PrincipIes of WhoIe Attack at Spur

    Institute of Scientific and Technical Information of China (English)

    靳鑫

    2015-01-01

    In order to learn from America basketball occupation League (NBA) spurs tactical concept, to provide reference for the study of basketball tactics in our country, the research and analysis of the NBA spurs assistant coach Jim in 2014 China Wuhan National Basketball Coaches job training teaching of technical and tactical drills, NBA2013-2014 season fifth finals with video analysis, the whole that spurs attack the basic principles of strategy: always keep the space open, taking the ball to the inside to attack the basket to mobilize the guard for the attack to attract, through the cut, roll, sudden grading and basic tactics flexible and changeable, the organic combination of internal and external opportunities, in equilibrium, outside attack, let the defender cannot determine the defensive focus, be kept constantly on the run.%为了借鉴美国男子篮球职业联赛(NBA)马刺队的战术理念,为我国篮球技战术研究提供参考,采用录像分析法对 NBA 马刺队助理教练吉姆在2014年武汉中国篮协全国教练员岗位培训班的授课技战术演练视频、NBA2013-2014赛季总决赛第五场视频进行研究分析,得出马刺队的整体进攻基本战术原则为:始终保持空间拉开,以球向内线转移向篮下进攻吸引调动防守为进攻起势,通过空切、挡拆、突分等灵活多变的基础战术配合,内外有机结合寻找机会,内、外线均衡进攻,让防守方无法确定防守的侧重点,疲于奔命。

  17. Kes tahab elada raudtee ääres? : kortermajad Õie tn. 2 Nõmmel = WhoWants to Live Next to the Railway? : apartment buildings Õie St. 2 in Nõmme / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2005-01-01

    Kolm viie korteriga kolmekorruselist korterelamut. Projekteerija: Arhitektuuribüroo Pluss. Autor Indrek Allmann. Konstruktsioonid: E-Inseneribüroo. Detailplaneering: Koot & Koot. Projekt: 2003, valmis: 2005. Ill.: katusekorruse ja tüüpkorruse plaan, 5 värv. välisvaadet

  18. Kes tahab elada raudtee ääres? : kortermajad Õie tn. 2 Nõmmel = WhoWants to Live Next to the Railway? : apartment buildings Õie St. 2 in Nõmme / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2005-01-01

    Kolm viie korteriga kolmekorruselist korterelamut. Projekteerija: Arhitektuuribüroo Pluss. Autor Indrek Allmann. Konstruktsioonid: E-Inseneribüroo. Detailplaneering: Koot & Koot. Projekt: 2003, valmis: 2005. Ill.: katusekorruse ja tüüpkorruse plaan, 5 värv. välisvaadet

  19. New trends of Chinese Compliments and Compliment Responses—Stud?ied With Gender and Age%New trends of Chinese Compliments and Compliment Responses—Stud⁃ied With Gender and Age

    Institute of Scientific and Technical Information of China (English)

    严佳琳

    2016-01-01

    Through comparing the data collected in different time, this paper explores the changes of Chinese compliments and compliment responses during the recent fifteen years, and also studies the differences of compliments and compliment responses among different genders and generations as well as different cultures in order to have a better communication and to better adapt in these rapidly developed world.

  20. 利用QbD理念进行埃索美拉唑钠杂质检测方法的研究%Studies on Impurity Detection Method of EsomeprazoIe sodium by QbD PrincipIes

    Institute of Scientific and Technical Information of China (English)

    陈洁; 吕旭幸; 王丽云

    2015-01-01

    ABSTRACT:OBJECTIVE To establish a impurity detection method of esomeprazole sodium by using Quality by Design (QbD) principles.METHODS Agilent Zorbax Extend C18(4.6mm ×250mm,5μm)was used with acetoni-trile-phosphate buffer ( pH 7.6 )-Water as the mobile phase ,at the flow rate of 1.0 mL・ min -1 .The column tempera-ture was set at 40℃, The detection wavelength was 280 nm and 265 nm.RESULTS The method could effectively detected the impurities predict by the QbD principles with high sensitivity , good specificity and accura-cy.CONCLUSION Impurities study using QbD principles can truly and effective response the esomeprazole sodi -um’ s quality,and avoiding impurity detection insufficiency .%目的:利用质量源于设计(QbD)的理念进行埃索美拉唑钠杂质研究,并论述了基于上述理念进行的杂质检测方法开发的过程。方法色谱柱为安捷伦Zorbax Extend C18(250mm ×4.6mm,5μm),流动相采用乙腈-磷酸盐缓冲液(pH 7.6)-水梯度洗脱,流速1.0mL・ min -1,柱温:40℃,检测波长:280nm与265nm。结果本方法能有效检测到利用QbD预测的各个杂质,方法灵敏度高,专属性好,准确度佳。结论利用QbD理念指导埃索美拉唑钠杂质研究,能真实有效的反应产品的杂质水平,避免杂质检测不全。

  1. 四川泡菜可培养微生物菌群的研究%Reaserch of CuIturabIe MicrobiaI Community in Sichuan PickIes

    Institute of Scientific and Technical Information of China (English)

    张晓娟; 夏珊; 陈洁; 冯霞; 刘松青

    2015-01-01

    207 bacteria are isolated from Sichuan pickles through traditional microbial isolation method.Being Identified by 16S rRNA sequence analysis,most of them can be identified to the species level, the dominant strains are Lactobacillus sp., including Lactobacillus plantarum , Lactobacillus casei ,Lactobacillus brevis ,Lactobacillus coryniformis and so on.Pediococcus sp., Staphylococcus sp.,Streptococcus sp.,Leuconostoc sp.,Enterococcus sp.are also isolataed.91 strains of yeast are isolated,they were identified to species level by 26S rRNA D1/D2 sequence analysis, including Debaryomyces hansenii ,Pichia anomala , Pichia membranifaciens , Pichia galeiformis ,Saccharomyces bulderi ,Saccharomyces servazzii .%对四川泡菜可培养微生物进行分离鉴定,并做系统发育及菌群多样性分析。细菌共分离207株,采用16S rRNA 序列分析进行鉴定,大部分可鉴定到种的水平,优势菌为乳杆菌属,包括植物乳杆菌(Lactobacillus plantarum )、干酪乳杆菌(Lactobacillus casei )、短小乳杆菌(Lactobacillus brevis )、棒状乳杆菌(Lactobacillus coryniformis )等共计11个种;还分离到片球菌属(Pediococcus sp.)、葡萄球菌属(Staphylococcus sp.)、链球菌属(Streptococcus sp.)、明串珠菌属(Leuconostoc sp.)、肠球菌属(Enterococcus sp.)。酵母共分离91株,采用26S rRNA D1/D2序列分析进行鉴定,均鉴定到种的水平,包括汉逊德巴利酵母(Debaryomyces hansenii )、异常毕赤酵母(Pichia anomala )、膜璞毕赤酵母(Pichia membranifaciens )、盔状毕赤酵母(Pichia galeiformis )、Saccharomyces bulderi 、Saccharomyces servazzii 。

  2. 76 FR 24856 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-05-03

    ..., and Picks & Mattocks) From the People's Republic of China: Final Results of the Expedited Sunset... & Adzes, Bars & Wedges, Hammers & Sledges, and Picks & Mattocks) from the People's Republic of China..., track tools and wedges; (3) picks and mattocks; and (4) axes, adzes and similar hewing tools. Hand...

  3. 76 FR 52313 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-08-22

    ..., and Picks & Mattocks) From the People's Republic of China: Continuation of Antidumping Duty Orders... & Adzes, Bars & Wedges, Hammers & Sledges, and Picks & Mattocks) (``Hand Tools'') from the People's... & Wedges, Hammers & Sledges, and Picks & Mattocks) From the People's Republic of China: Final Results...

  4. Teaching Academic Content and Literacy to English Learners in Elementary and Middle School. IES Practice Guide. NCEE 2014-4012

    Science.gov (United States)

    Baker, Scott; Lesaux, Nonie; Jayanthi, Madhavi; Dimino, Joseph; Proctor, C. Patrick; Morris, Joan; Gersten, Russell; Haymond, Kelly; Kieffer, Michael J.; Linan-Thompson, Sylvia; Newman-Gonchar, Rebecca

    2014-01-01

    As English learners face the double demands of building knowledge of a second language while learning complex grade-level content, teachers must find effective ways to make challenging content comprehensible for students. This updated English learner practice guide, "Teaching Academic Content and Literacy to English Learners in Elementary and…

  5. Ammonium recruitment and ammonia transport by <i>E. coli ammonia channel AmtB

    DEFF Research Database (Denmark)

    Nygaard, Thomas Pedersen; Rovira, C.; Peters, Günther H.j.

    2006-01-01

    To investigate substrate recruitment and transport across the Escherichia coli Ammonia transporter B (AmtB) protein, we performed molecular dynamics simulations of the AmtB trimer. We have identified residues important in recruitment of ammonium and intraluminal binding sites selective of ammoniu...

  6. Sound velocity from inverted echo sounders (IES) in the western Pacific Ocean from 19920826 to 19930322 (NODC Accession 9300159)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains inverted echo sounder data collected from two stations in the western Pacific, TPW nominally @ 2S and 154E and TPE nominally @ 2S and 164E....

  7. Tööandja kulutused töötajatele, 2000 / Mare Kusma, Õie Palmre

    Index Scriptorium Estoniae

    Kusma, Mare

    2002-01-01

    Statistikaameti poolt esmakordselt korraldatud vaatluse "Tööandja kulutused töötajatele" metoodika ja tulemused. Summary: Labour costs, 2000. Tööjõukuludega seotud mõistete definitsioonid. Tabelid ja diagrammid

  8. The Effects of Cognitive Strategies i.e. Note-Making and Underlining on Iranian EFL Learners’ Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Amir Mahdavi

    2012-11-01

    Full Text Available The purpose of this study was to investigate the effects of using cognitive strategies namely note- making and underlining, on Iranian EFL learners’ reading comprehension. In doing so, 60 female fourth year high school EFL learners were selected by means of the NELSON test (050A. They were then divided randomly into three groups, each group consisting of 20 homogeneous students: two experimental groups, and one control group. The experimental groups practiced note making (group A and underlining reading strategies (group B on the same reading materials while the control group received the placebo. Then, all the subjects in the three groups took the same reading comprehension test. The results of a One-way Analysis of Variance (ANOVA and a post-hoc analysis of the Scheffe test showed that the learners who utilized note-making and underlining strategies outperformed the control group (p<.05. Furthermore, the experimental group who received note-making instruction revealed a higher efficiency than underlining group. As a result it can be concluded that note making and underlining have had positive effects on students’ rate of reading comprehensibility.Keywords: Cognitive Strategies, Note- Making, Underlining, Reading Comprehension

  9. THE RSDLP FOREIGN DELEGATION AND ITS ROLE IN THE EUROPEAN SOCIAL-DEMOCRATIC MOVEMENT IN THE 1930-IES

    Directory of Open Access Journals (Sweden)

    Svetlana Mikhailovna SMAGINA

    2014-01-01

    Full Text Available The article considers the little-studied aspect of the Rus-sian Social Democrats’ [Mensheviks] activity in emigra-tion, especially, the RSDLP Foreign Delegation governing body (1922–1951. Recognizing “the transitional nature of the era” and participating in the discussion of the inter-national socialist movement, the Mensheviks last played a public role in the political life of pre-war Europe and development of the “tactical formula” of the common activities organization.

  10. Development and Performance of an Ultrawideband Stepped-Frequency Radar for Landmine and Improvised Explosive Device (IED) Detection

    Science.gov (United States)

    Phelan, Brian R.; Gallagher, Kyle A.; Sherbondy, Kelly D.; Ranney, Kenneth I.; Narayanan, Ram M.

    2014-11-01

    Under support from the Army Research Laboratory's Partnerships in Research Transition program, a stepped-frequency radar (SFR) is currently under development, which allows for manipulation of the radiated spectrum while still maintaining an effective ultra-wide bandwidth. The SFR is a vehicle-mounted forward-looking ground-penetrating radar designed for high-resolution detection of buried landmines and improvised explosive devices. The SFR can be configured to precisely excise prohibited or interfering frequency bands and also possesses frequency-hopping capabilities. This paper discusses the expected performance features of the SFR as derived from laboratory testing and characterization. Ghosts and artifacts appearing in the range profile arise from gaps in the operating band when the system is configured to omit specific frequencies. An analysis of these effects is discussed and our current solution is presented. Future prospects for the SFR are also discussed, including data collection campaigns at the Army's Adelphi Laboratory Center and the Countermine Test Site.

  11. Comprehensiveness of HIV care provided at global HIV treatment sites in the IeDEA consortium: 2009 and 2014

    Directory of Open Access Journals (Sweden)

    Cristin Q Fritz

    2017-01-01

    Conclusions: The availability of viral load monitoring remains suboptimal and should be a focus for site capacity, particularly in East and Southern Africa, where the majority of those initiating on ART reside. However, the comprehensiveness of care provided increased over the past 5 years and was related to type of funding received (publicly funded and PEPFAR supported.

  12. Hydrodynamic Noise and Surface Compliance--An Overview of the Naval Underwater Systems Center IR/IED Program

    Science.gov (United States)

    2015-05-21

    34 COATING WAS BASICALLY A VERSION OF A " DOLPHIN -LIKE" SURFACE DEVISED TO EXTEND KRAMER’S WELL KNOWN DRAG REDUCTION INVESTIGATIONS INTO THE FLOW NOISE...EVEN DESCRIBED IN WHICH A DOLPHIN WAS INSTRUMENTED WITH FLUSH PRESSURE TRANSDUCERS. HOWEVER, NO DATA WERE GIVEN. ONE OF THE LATEST EXPERIMENTS...OBTAINED USING A LASER DOPPLER VELOCIMETER. FINALLY LASER HOLOGRAPHY OR LASER SURFACE SLOPE MEASUREMENTS WILL BE UTILIZED TO CHARACTERIZE THE SURFACE

  13. Natives assembled to be taxed, in a native kraal, S.R. [? Southern Rhodesia (i.e. Zimbabwe)

    OpenAIRE

    Bathurst, Charles, 1867-1958, 1st Viscount Bledisloe

    2003-01-01

    The photograph is published in: Rhodesia-Nyasaland Royal Commission Report. Presented to Parliament by Command of His Majesty, March, 1939. London: H.M.S.O., 1939. The Rhodesia-Nyasaland Royal Commission arrived at Bulawayo on 16 May 1938, moved to Nyasaland (now called Malawi), reaching Zomba on 17 June, thence to Northern Rhodesia (now called Zambia) on 8 July, returning to Salisbury on 14 August and leaving Rhodesia on 20th. Crown Copyright Photograph.

  14. Sewing Class at Jeanes Training Centre, Hope Fountain, S.R. [? Southern Rhodesia (i.e. Zimbabwe)

    OpenAIRE

    Bathurst, Charles, 1867-1958, 1st Viscount Bledisloe

    2003-01-01

    The photograph is published in: Rhodesia-Nyasaland Royal Commission Report. Presented to Parliament by Command of His Majesty, March, 1939. London: H.M.S.O., 1939. The Rhodesia-Nyasaland Royal Commission arrived at Bulawayo on 16 May 1938, moved to Nyasaland (now called Malawi), reaching Zomba on 17 June, thence to Northern Rhodesia (now called Zambia) on 8 July, returning to Salisbury on 14 August and leaving Rhodesia on 20th. Crown Copyright Photograph.

  15. Managing the IE (Industrial Engineering Mindset: A quantitative investigation of Toyota’s practical thinking shared among employees

    Directory of Open Access Journals (Sweden)

    Phillip Marksberry

    2011-12-01

    Full Text Available Purpose: The goal of this work was to investigate the managerial practices of today to understand if Toyota is sheltering themselves from these newer practices or embracing them like most believe.Design/methodology/approach: This work utilizes a new form of data mining named Latent Semantic Analysis (LSA to analyze an organizations ideal management practices.Findings: This work shows quantitatively that TPS favors earlier versions of industrial engineering compared to the optimization techniques available today.Originality/value: The use of data mining to analyze organizational management practices.

  16. Land reform in Russia in 1990-2000-ies, or how land reform was "reformed" during the departmental reorganization

    Directory of Open Access Journals (Sweden)

    Barsukova Svetlana, Yu.

    2015-06-01

    Full Text Available The paper provides an overview of the land reform in Russia's recent history. Analysis of land reform, which started in 1990, shows what actions and what logic led the land sector in the state in which it was at the finish line of the quarter-century reform marathon. The reform process was not linear, it highlighted the steps differing objectives and strategies to achieve them. Land reform is presented as a struggle of different political forces, which were reflected in the redistribution of functions between agencies in lobbying for appointment to senior positions promoted various commands. The authors conclude about the gradual displacement of state regulation of land relations, the deliberate destruction of the land management as a basis for the development of land resources.

  17. Energy renovation of school building from the 1970'ies; Energirenovering af typeskolebygning fra 1970'erne

    Energy Technology Data Exchange (ETDEWEB)

    Tommerup, H.

    2010-08-15

    The project has aimed to develop methods and examples related to the design of energy extensive renovations (low energy class 1), thereby stimulating energy conservation and increased use of renewable energy in existing buildings. This report is based on analysis of a specific type of school building from the 1970s on how it is technically and economically feasible to implement an extensive energy renovation. The survey shows that no single approach is able to bring the building's energy consumption down to BR08 (building code 2008) level. The study also shows that to achieve the BR08's low energy class one level, it is necessary to use a solar heating system. Economic calculations show that 12 out of 15 proposed energy-saving measures are economically viable. With longer lifetimes than specified in BR08 largely all actions are profitable. This profitability of most of the actions depends on some of the investment being considered as general maintenance or as a measure that also improves comfort and indoor climate. (ln)

  18. ied ja sõlmed tõid Katrina Kaubile võidu / Monika Puutsa

    Index Scriptorium Estoniae

    Puutsa, Monika

    2007-01-01

    Supernoova moevõistluse tulemustest. Noorte disainerite auhind Katrina Kaubile oli 20 000 krooni ja Supernoova hõbedane pross, vanemas kategoorias Liisi Eesmaale 50 000 krooni. Žürii koosseis. Katrina Kaubi kommentaarid

  19. The Hungarian Counter Improvised Explosive Device (C-IED) Strategy: Considering the Use of Military Working Dogs

    Science.gov (United States)

    2014-12-12

    dogs, and some of them will have residual weaknesses or health injuries connected with heat stroke (Strock 2011, 15). 39 Both hounds and Labradors...Military working dogs, like soldiers, can suffer from job task overload and job related stress . In operations, dogs have become overwhelmed with tasks...dog needs. For every fifty pounds of the animal’s weight, the dog needs a half pound of meat per day. The meat could be horse, beef or chicken , but

  20. Presenting Your Best Self(ie): The Influence of Gender on Vertical Orientation of Selfies on Tinder

    National Research Council Canada - National Science Library

    Lorin J. Elias; Jennifer R. Sedgewick; Meghan E. Flath

    2017-01-01

    .... Concepts from evolutionary psychology and grounded cognition suggest that this manipulation can provide cues of physical height and impressions of power to the viewer which are qualities found...

  1. Student-Teachers' Backgrounds and Motives for Teaching: A 1968-1981 Comparison. IE Occasional Paper No. 11.

    Science.gov (United States)

    Soh, Kay-Cheng

    A major change which has taken place in Singapore is the introduction of full-time teacher training programs to replace part-time programs. This study compared characteristics and motives for teaching of full-time students admitted into the teacher education program in 1981 with those of part-time students of the late 1960s. A background of the…

  2. 11 CFR 300.63 - Exception for State candidates (2 U.S.C. 441i(e)(2)).

    Science.gov (United States)

    2010-01-01

    ... simultaneously running for both Federal and State or local office, the individual must raise, accept, and spend... or individual holding Federal office who is a candidate for State or local office, if the solicitation, receipt or spending of funds is permitted under State law; and refers only to that State or...

  3. Self(ie-esteem? – A manifestation of adolescent self-creating endeavours in the virtual space of Facebook

    Directory of Open Access Journals (Sweden)

    Lili Fejes-Vékássy

    2017-09-01

    Full Text Available In the centre of our interest stand the manifestations of adolescent self-creating endeavours in the virtual space of the social media portal called Facebook. Frequent self-photography (selfie making, as a pronounced cultural feature of contemporary youth, and regular activity on Facebook handled as tightly connected factors; we propose that youngsters, bearing these attributes, have a different self-esteem than those adolescents who rarely or never take any photographs of themselves. In the first, quantitative part of our research the participants (N=80 filled in the Rosenberg Self-Esteem Scale and a questionnaire containing questions in connection with Facebook-usage (compiled by us. In the qualitative part of the research the participants took part in a half-structured interview, containing questions in connection with selfie­-making (also compiled by us. Our hypothesis was not proven by the statistical analysis, no connection could be testified between frequent selfie-making and low self-esteem.

  4. PROCESUL DE CONSTRUCŢIE EUROPEANĂ ÎN PRIMA JUMĂTATE A SECOLULUI AL XX-LEA

    Directory of Open Access Journals (Sweden)

    Anton Florin Bota

    2006-05-01

    Full Text Available Dans l’étude “Le processus de construction européenne de la première moitié du XX-ème siècle”, l’auteur se propose de présenter les principaux moments du développement de l’idée inter-européenne, les étapes de la construction européenne – marquées par la théorie fédéraliste et fonctionnelle, concrétisées dans l’approche intergouvernementale – et l’apparition des organismes internationaux intergouvernementaux de coopération classique, tout comme dans l’approche communautaire – et l’apparition des organismes supranationaux à partir du 9 mai 1950, lorsque la présentation du plan Schuman a eu lieu.

  5. IE - RISS: UNA HERRAMIENTA COMPUTACIONAL PARA LA ESTIMACIÓN DE PÉRDIDAS POR SISMO EN EDIFICACIONES

    Directory of Open Access Journals (Sweden)

    CÉSAR AUGUSTO SIERRA ÁLVAREZ

    2012-01-01

    Full Text Available Una formulación probabilista para estimar tasas de excedencia de pérdidas por terremoto es presentada. Luego de exponer la utilidad de este tipo de modelos se presenta la formulación matemática de un modelo Poissoniano que considera la incertidumbre de variables tales como: magnitud en la fuente, intensidad del movimiento en el basamento rocoso, intensidad del movimiento a nivel de la superficie del suelo y daño en las edificaciones. Los resultados se sintetizan en las tasas de excedencia anual para un nivel de pérdida determinado, ya sea para cada una de las edificaciones afectadas, para un grupo de ellas o para todo el conjunto. Finalmente, para una cartera ficticia que considera diferentes combinaciones de tipos de edificaciones, tipos de suelo y localizaciones geográficas, se calculan las tasas de excedencia de pérdidas. Los resultados muestran cómo las pérdidas podrían ser fuertemente influenciadas por la ubicación y por el sistema estructural de las edificaciones.

  6. 44 CFR 60.4 - Flood plain management criteria for mudslide (i.e., mudflow)-prone areas.

    Science.gov (United States)

    2010-10-01

    ... ground water or surface water problems, (iii) the depth and quality of any fill, (iv) the overall slope... engineering, (ii) the proposed grading, excavations, new construction, and substantial improvements are... the Federal Insurance Administrator which (i) regulates the location of foundation systems and...

  7. Evidence for Water Ie on the Moon: Results for Anomalous Polar Craters from the LRO Mini-RF Imaging Radar

    Science.gov (United States)

    Spudis, P.D.; Bussey, D. B. J.; Baloga, S. M.; Cahill, J. T. S.; Glaze, L. S.; Patterson, G. W.; Raney, R. K.; Thompson, T. W.; Thomson, B. J.; Ustinov, E. A.

    2013-01-01

    The Mini-RF radar instrument on the Lunar Reconnaissance Orbiter spacecraft mapped both lunar poles in two different RF wavelengths (complete mapping at 12.6 cm S-band and partial mapping at 4.2 cm X-band) in two look directions, removing much of the ambiguity of previous Earth- and spacecraft-based radar mapping of the Moon's polar regions. The poles are typical highland terrain, showing expected values of radar cross section (albedo) and circular polarization ratio (CPR). Most fresh craters display high values of CPR in and outside the crater rim; the pattern of these CPR distributions is consistent with high levels of wavelength-scale surface roughness associated with the presence of block fields, impact melt flows, and fallback breccia. A different class of polar crater exhibits high CPR only in their interiors, interiors that are both permanently dark and very cold (less than 100 K). Application of scattering models developed previously suggests that these anomalously high-CPR deposits exhibit behavior consistent with the presence of water ice. If this interpretation is correct, then both poles may contain several hundred million tons of water in the form of relatively "clean" ice, all within the upper couple of meters of the lunar surface. The existence of significant water ice deposits enables both long-term human habitation of the Moon and the creation of a permanent cislunar space transportation system based upon the harvest and use of lunar propellant.

  8. Dinamica relației dintre migrație și dezvoltare. Perspective asupra cazului Republicii Moldova

    Directory of Open Access Journals (Sweden)

    Cristina HARUȚA

    2016-12-01

    Full Text Available International migration has been associated for decades either with development or with underdevelopment of the origin and destination countries. For those who highlight the positive link between migration and development the benefits of human mobility reside in the financial and social remittances of the migrants, the brain gain, the transfers of goods/ideas/capital, strengthened local economies in countries of origin and alleviated levels of poverty in migrant households etc. Nonetheless, the existing empirical studies have shown that the migration-development nexus is complex and by no means unidirectional, therefore any context in which a certain degree of modernization or development is claimed to occur due to migration, has to be analyzed thoroughly and approached skeptically. The focus of this article is the migratory process in Republic of Moldova. I attempt to deconstruct and to analyze a range of different stances and perspectives that apply to migration and development in Moldova, although some of them have not been entirely validated from an empirical standpoint.

  9. 基于:Internet Explorer的VR化学实验的实现%Chemistry Experiment Based On VR and IE

    Institute of Scientific and Technical Information of China (English)

    马颖峰; 周春雷

    2001-01-01

    @@ VR是虚拟现实(Virtual Reality)的缩写,"虚拟现实是指用计算机生成的一种特殊的环境,人可以通过使用各种特殊的装置将自己投射到此环境中去操作、控制和感受环境,实现特殊的目的".虚拟现实建模语言(VRML)已成为3D文件的交换、描述标准,对于基于Internet Explorer的网络教学软件开发具有非常重要的意义.

  10. The Social Composition of the Service Class and Urban Population of the South of Russia in 1640–1650-ies

    Directory of Open Access Journals (Sweden)

    Denis A. Lyapin

    2016-09-01

    Full Text Available The article is devoted to analysis of the social composition of the public service as the urban population of the South of Russia in the middle of XVII century on the basis of archival documents. The main source of work was the List of the Russian army in 1651. In 1640-1650 in Russia there is an important socio-political changes which influenced the social structure of society. Especially these processes are reflected region on the southern border of the state. Here appeared and spread rapidly regiment of the new system, first of all, dragoons. In the cities the growing number of urban population, which accounted for some of these, about 40% of the population, and if to this number be added 10% of privately owned households, that is obtained for the first time since early settlement in the region, serving the population in large cities has caught up with citizens («posadskie». After 1650 was scrapping the social structure of local society: urban population began to grow steadily, and servitors to fall. The article shows that these processes have been associated not only with the military reform and the specifics of colonization, which we discussed at the beginning of our article. In our opinion, the first reason of the changes (especially in cities became the policy of the B. I. Morozov’s government 1645-1648, conducted so-called «urban structure». After 1649, the privileges in trade got trades people and servicemen for instrument proposed to move in this social category and become taxpaying members of the town community. The occupation of trade and craft activity was declared a monopoly of the townspeople.

  11. [Priorities for health improvement in the medical personnel of phthisiatric service in the Primor'ie Territory].

    Science.gov (United States)

    Bektasova, M V; Kaptsov, V A; Sheparev, A A

    2012-01-01

    The authors analyze occupational morbidity rates in the medical personnel of tuberculosis facilities in the Primorsky Territory, as well as the location of the institutions (workrooms) and the influence of occupational factors on medical workers. The nature of work and working conditions in the medical workers of a tuberculosis facility where they are exposed to occupational hazards in practically 100% of cases necessitate effective measures to promote and preserve their health. The absence of standard buildings and premises for tuberculosis facilities and the low efficiency of rehabilitative sanatorium-and-spa treatment, health improvement, and the prevention of occupational diseases are one of the problems of a tuberculosis service in the Primorsky Territory. The findings serve as the basis for the development of an approach to preventing occupational diseases and recovering the health status among the medical workers who have experienced tuberculosis.

  12. Contrast and Assimilation Effects of Dimensional Comparisons in Five Subjects: An Extension of the I/E Model

    Science.gov (United States)

    Jansen, Malte; Schroeders, Ulrich; Lüdtke, Oliver; Marsh, Herbert W.

    2015-01-01

    Students evaluate their achievement in a specific domain in relation to their achievement in other domains and form their self-concepts accordingly. These comparison processes have been termed "dimensional comparisons" and shown to be an important source of academic self-concepts in addition to social and temporal comparisons. Research…

  13. Energy renovation of a house from the 1970'ies; Energirenovering af 70'er parcelhus

    Energy Technology Data Exchange (ETDEWEB)

    OEstergaard Jensen, S. (Teknologisk Institut. Energi og Klima, Taastrup (Denmark)); Weitzmann, P. (COWI, Kgs. Lyngby (Denmark))

    2010-06-15

    Based on a concrete single-family house from the 70s it is investigated if it is technically and economically feasible to introduce extensive energy renovations of single houses from the 60s and 70s. The investigations show that it is not possible with one single action to bring the energy demand down to the level of BR08. In addition, the investigations show that it often is technically difficult to implement the proposed solutions and limited savings are often obtained for the single measures - eg. an increase in the insulation level of the floor is in the example difficult as the floor slab is bearing and the height of the rooms only allows for a small increase in the internal thickness of the insulation. The investigations show that in order to reach low energy class 1 level of BR08 energy production in the form of solar heating and/or pv is necessary. The economical calculations show that 7 out of 16 proposed single action are economically profitable. With a longer life time than indicated in BR08, another 3 actions becomes profitable. For most of the actions, profitability depends on the fact that part of the investment may be regarded as ordinary maintenance or a measure to increase comfort and indoor climate - so the entire investment does not have to be paid back through energy savings. Upgrading of the house to low energy class 1 of BR08 is not profitable no matter which of the three applied economical indicators are used. But if the house after all is being upgraded to the level of BR08 it is profitable to go all the way and future proof the house to low energy class 1. (LN)

  14. Accidents - Policy and Punishment Are there boundar ies to the effectiveness of cr iminal sanctions in preventing accidental conduct?

    Science.gov (United States)

    Fisher, Alan

    This paper discusses recent and impending changes in Health and Safety law, questions the utility and supposed justification of tougher criminal sanctions and appeals for greater clarity in health and safety law as to what is truly a criminal offence. It also questions the use of the ‘reverse burden of proof’ and warns against unintended consequences if responsible people are made to feel that they are being treated unfairly.

  15. The Study on Neuro-IE Management Software in Manufacturing Enterprises. -The Application of Video Analysis Technology

    Science.gov (United States)

    Bian, Jun; Fu, Huijian; Shang, Qian; Zhou, Xiangyang; Ma, Qingguo

    This paper analyzes the outstanding problems in current industrial production by reviewing the three stages of the Industrial Engineering Development. Based on investigations and interviews in enterprises, we propose the new idea of applying "computer video analysis technology" to new industrial engineering management software, and add "loose-coefficient" of the working station to this software in order to arrange scientific and humanistic production. Meanwhile, we suggest utilizing Biofeedback Technology to promote further research on "the rules of workers' physiological, psychological and emotional changes in production". This new kind of combination will push forward industrial engineering theories and benefit enterprises in progressing towards flexible social production, thus it will be of great theory innovation value, social significance and application value.

  16. Supplemental specifications of laboratory hot press process -- For CV size self-supported I&E fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Burgess, C.A.; Schweikhardt, G.M.

    1964-06-01

    Some refinements have been introduced into the hot press canning of internally and externally cooled fuel elements. This report outlines the specifications for the process including these refinements. Specifications cover components, dies, and punches, furnace condition, nickel plating, component cleaning, component assembly, sizing, hot pressing and inspection.

  17. The extent to which inscriptional evidence may serve as a source of "vulgar," i.e. spoken Latin

    Directory of Open Access Journals (Sweden)

    Paul A. Gaeng

    1992-12-01

    Full Text Available "Itis incumbent on Romance scholars to analyze and interpret their exceptionally full stock of linguistic material, using all methods of study at their disposal, working both backward and forward in time. Only thus will Romance linguistics be enabled to do what others expect of it: to serve not only as an end in itself but as a model and training-ground for workers in all fields of historical linguistics." Thus wrote the American scholar, Robert A. Hall, jr. some forty years ago in an essay on the recon­ struction of Proto-Romance. 1 Indeed, the researcher into the history of the Romance languages is faced with, on the one hand, the schemes of reconstruction (essentially based on the principles of the historical comparative method and the often puzzling testimonies of reality found in the sources. Put in other terms, he has the choice of working with an abstract system represented by starred Latin forms that do not belong to any real language or the reality of the mass of postclassical written records that have come down to us to be analyzed and sifted through with a view to discovering evidences of trends toward Romance in phonology, morpho-syntax, and vocabulary. And while there are, no doubt, materials whose meaning in terms of future evolution of the Romance languages is difficult, if not impossible to discover, there is an abun­ dance of those that prelude the future. It is the attention to the future that, I believe, can give reality and life to the large number of forms collected from inscriptions, late writers, and other sources of so-called "Vulgar", i. e. non-literary Latin.

  18. Propuesta académico - organizacional para un centro de educación continua virtual en una IES Ecuatoriana

    National Research Council Canada - National Science Library

    Ricardo Patricio Medina Chicaiza; Teresa Milena Freire Aillón; Galo Mauricio López Sevilla

    2016-01-01

    .... Se partio de un analisis de la educacion continua ofertada por los centros educativos de la zona 3 del Ecuador, donde se evidencio la falta de credibilidad en la entrega de certificados, deficiencias...

  19. Thermal and physical property determination for IONSIV/256 IE-911 crystalline silicotitanate and Savannah River Site waste simulant solutions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-08

    This document describes physical and thermophysical property determinations that were made in order to resolve questions associated with the decontamination of Savannah River Site waste streams using ion exchange on crystalline silicotitanate.

  20. IED Campaign in the U.S. Homeland: Are U.S. Military EOD Units Prepared to Respond

    Science.gov (United States)

    2017-06-09

    military’s categories for capabilities development : doctrine, organization , training, materiel, leadership and education, personnel, and facilities...military’s Joint Capabilities Development (JCD) system used to create and evolve military capabilities through changes in doctrine, organization ... organization without requiring a lengthy and expensive acquisitions or force development solution. A materiel solution for the primary or secondary research

  1. Studiul structurii betonului ca mediu de protecţie a armăturilor împotriva coroziunii

    Directory of Open Access Journals (Sweden)

    Gheorghe Croitoru

    2011-09-01

    Full Text Available The paper presents a study of the processes of reinforcementcorrosion in concrete structures as a consequence of aggressive infiltration of water through cracks in the concrete. The rate of corrosion of reinforcement in concrete depends on the density and moisture content of concrete. Determine the effect of relative humidity (60 %, 80 %, 95 % on the rate of reinforcement corrosion, cracks in the zone, held in thermohydrostatic cells at 50 ° C, at high concentrations of oxygen and carbon dioxide than the environment. Duration of tests, depending on the degree of aggressiveness of the medium ranged from several days to severalmonths. During the tests, controlled temperature, relative humidity, gas concentration, humidity of the concrete and the environment. Whenhumidity variation from 35 to 60 %, the resistance of concrete increases slightly. With increasing relative humidity up to 80 % or more, the ohmic resistance decreases and the corrosion of reinforcement can have rapid development.

  2. Technology and Key Strategy of IE4 Permanent Magnet Brushless DC Motor Drive for Electric Vehicle Application

    Directory of Open Access Journals (Sweden)

    Nitin Subramonium A K

    2017-03-01

    Full Text Available Environmental protection and energy conservations are the main concern of 21st century Asia Pacific developing countries. This concern has compelled to design and develop zero pollution road transportation Electric Vehicles (EVs. The EV system consist of energy storage devices such as battery, fuel cell, ultra-capacitors along with electric propulsion, body of the vehicle and energy management system with the diversified technology of electrical, electronics, mechanical, automotive and chemical engineering. The objective of electric vehicle is to produce commercial viable range, efficient performance, and comfort with safety and reliable operations at cheaper price than its counterpart the Internal Combustion Engine Vehicle (ICEV. The PMBLDC motors are the present choice of automobile industries and researchers because of its high power density, compact size, reliability, with noise free and minimum maintenance requirements. The present state of art Permanent Magnet Brushless DC (PMBLDC Motor drive for the electric vehicle application is studied / reviewed in this paper.. In addition the study also reveals the advancement of the Power Processing Unit (PPU which consists of Microelectronics and Controls (Me and C to produce the super-premium efficiency PMBLDC drive system for EV applications.

  3. A novel forward and backward scattering wave measurement system for optimizing GPR standoff mine/IED detector

    Science.gov (United States)

    Fuse, Yukinori

    2012-06-01

    Standoff detection of mines and improvised explosive devices by ground penetrating radar has advantages in terms of safety and efficiency. However, the reflected signals from buried targets are often disturbed by those from the ground surface, which vary with the antennas angle, making it more difficult to detect at a safe distance. An understanding of the forward and backward scattering wave is thus essential for improving standoff detection capability. We present some experimental results from using our measurement system for such an analysis.

  4. Immunologic response in treatment-naïve HIV-2-infected patients: the IeDEA West Africa cohort

    Directory of Open Access Journals (Sweden)

    Eric Balestre

    2016-02-01

    Full Text Available Introduction: Response to antiretroviral therapy (ART among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs to boosted protease inhibitor (PI and unboosted PI-based regimens in West Africa. Methods: This prospective cohort study enrolled treatment-naïve HIV-2-infected patients within the International Epidemiological Databases to Evaluate AIDS collaboration in West Africa. We used mixed models to compare the CD4 count response to treatment over 12 months between regimens. Results: Of 422 HIV-2-infected patients, 285 (67.5% were treated with a boosted PI-based regimen, 104 (24.6% with an unboosted PI-based regimen and 33 (7.8% with three NRTIs. Treatment groups were comparable with regard to gender (54.5% female and median age at ART initiation (45.3 years; interquartile range 38.3 to 51.8. Treatment groups differed by clinical stage (21.2%, 16.8% and 17.3% at CDC Stage C or World Health Organization Stage IV for the triple NRTI, boosted PI and unboosted PI groups, respectively, p=0.02, median length of follow-up (12.9, 17.7 and 44.0 months for the triple NRTI, the boosted PI and the unboosted PI groups, respectively, p<0.001 and baseline median CD4 count (192, 173 and 129 cells/µl in the triple NRTI, the boosted PI and the unboosted PI-based regimen groups, respectively, p=0.003. CD4 count recovery at 12 months was higher for patients treated with boosted PI-based regimens than those treated with three NRTIs or with unboosted PI-based regimens (191 cells/µl, 95% CI 142 to 241; 110 cells/µl, 95% CI 29 to 192; 133 cells/µl, 95% CI 80 to 186, respectively, p=0.004. Conclusions: In this observational study using African data, boosted PI-containing regimens had better immunological response compared to triple NRTI combinations and unboosted PI-based regimens at 12 months. A randomized clinical trial is still required to determine the best initial regimen for treating HIV-2 infected patients.

  5. CONSIDERAŢII PRIVIND LIBERA CIRCULAŢIE A PERSOANELOR ÎN SPAŢIUL JURIDIC AL UNIUNII EUROPENE

    Directory of Open Access Journals (Sweden)

    Mirela Paula Costache

    2007-05-01

    Full Text Available La Directive 2004/38 relative au droit des citoyens de l’Union Européenne et des membres de leursfamilles de circuler et de séjourner librement sur le territoire des Etats membres est analysée de manièreglobale. Il en ressorte qu’elle procède plus à une refonte du droit existant de la libre circulation des personnesen codifiant les textes et en intégrant les acquis de la jurisprudence qu’à une transformation du droit. Il esttoutefois certain que des progrès sensibles sont réalisés dans la libre circulation des personnes, notamment parla création d’un droit de séjour permanent et par la clarification des conditions d’accès à l’aide sociale.

  6. Comparing the anti-inflammatory effects of Simvastatin and Rosuvastatin by measuring IL-1β, IL-6 and TNF-α levels using a murinic caecal ligation and puncture induced sepsis model / Compararea efectelor anti-inflamatoare ale Simvastatinei și Rosuvastatinei măsurând nivelele serice ale IL-1β, IL-6 si TNF-α folosind un model de sepsis la șobolan indus prin ligatură și puncție cecală

    Directory of Open Access Journals (Sweden)

    Mărginean M Mihai

    2014-12-01

    Full Text Available Introducere: Sepsisul este o boala caracterizată printr-un răspuns sistemic inflamator cauzat o infecție care poate evolua către sepsis sever și șoc septic. Această patologie ridică mari probleme la nivel global din cauza mortalității ridicate (care în anumite situații atinge 30% precum și din cauza încarcăturii financiare mari. Sepsisul se caracterizează prin declasnșarea unor căi imune pro-inflamatorii cu rol de apărare a organismului dar care ulterior se dovedesc a fi extrem de dezajantajoase. Deși antibioterapia, resuscitarea volemică, terapia vasopresoare și controlul sursei de infecție rămân strategiile recomandate în tratamentul sepsisului, date publicate recent propun statinele ca o noua linie de tratament. Aceste medicamente au fost introduse în practica clinică datorită efectului hipocolesterolemiant însă inhibarea reductazei HMG-CoA și a biosintezei colesterolului induce o serie de efecte mai puțin studiate denumite generic pleiotrope: anti-inflamatoare, antitrombotice, imunomodulatoare și antioxidante. Obiective: În cadrul acestui experiment ne-am propus să evaluăm și să comparăm efectul antiinflamator al Simvastatinei și Rosuvastatinei măsurând nevelele serice ale IL-1β, IL-6 și TNF-α folosind un model consacrat de sepsis la șobolan. Metode: Am alcătuit patru grupuri (C, n=7; SEP, SV, RV, n=8. Statinele au fost administrate în două doze cu 18 și 3 ore înaintea intervenției chirurgicale. Sepsisul a fost obținut prin tehnica ligaturării și puncției cecale. De la fiecare subiect au fost recoltate eșantioane de sânge prin puncție venoasă în zilele 1, 4, 7 și 14 (ultimele eșantioane au fost obținute prin puncție cardiacă. Au fost analizați următorii parametrii: hemoleucograma, Procalcitonina, IL-1β, IL-6 și TNF-α. Rezultate: Numărul total al leucocitelor a fost mai mare pentru grupul septic dar netratat. Procalcitonina a fost reacționată în toate grupurile

  7. 关于降低方便面酱料成本的研究%Research on Reducing the Cost of Instant NoodIes Sauce

    Institute of Scientific and Technical Information of China (English)

    张立攀; 胡桂芳; 罗蓓蓓; 尹红娜; 张亚勋

    2016-01-01

    The cost control is an important management subject that all enterprises must face. Enterprises no matter what reform,incentive measures are no substitute for strengthening cost management,reducing the cost.In order to reduce the production cost,under the premise of ensuring the quality of instant noodles sauce (strong sauce flavor,the taste meets the design requirements;the shel-life reaches the design requirements;moderate density at room temperature,the state meets the package requirements),through improving the moisture content of instant noodles sauce to improve the yield,ultimately reducing the production cost.%成本控制是所有企业都必须面对的一个重要管理课题,是企业在竞争中取胜的关键战略问题。企业无论采取何种改革、激励措施都代替不了强化成本管理,降低成本这一工作。为了降低生产成本,在保证方便面酱料品质(酱香浓郁,口味达到设计要求;保质期达到设计要求;室温下稠度适中,状态符合包装要求)的前提下,通过提高方便面酱料含水量,提高酱料的出品率,最终降低生产成本。

  8. Who were the Clerks in Siberia? Professional Characteristics of Russian Empire Local Governmental Officials from the 19th to the early 20ies century

    Directory of Open Access Journals (Sweden)

    Tatyana G. Karchaeva

    2017-03-01

    Full Text Available This article discusses the history of the Siberian grassroots and their professional composition as Siberian government participation may reflect the processes taking place in Russian Imperia. The aim of this article is to look at the long-term evolution of Siberian employees' participation in the province’s administration in Yenisei province from 1822 to the 1917. The data on the officials in grassroots governance came from archival research, involving 447 clerks' biographies from Eastern Siberia. The documents were stored in the Russian State Historical Archive (St Petersburg, Russia and the State Archive of Krasnoyarsk Region (Krasnoyarsk, Siberia, Russia. It was an important source of empirical data on the work of the Siberian grassroots governance that was not available elsewhere. Social composition, education, working experience and criminal record were considered to identify a group of officials prevailing in local and regional government structures. In conclusion, we found that, in the first, dominance of Siberian clerks with primary education, quite an insignificant number of clerks with secondary and higher education confirm the idea that involving state employees in governance participation was complicated by their educational level. Secondly, clerks low socio‐economic stratums constituted the majority in the governance grassroots in the Eastern Siberia. In this region nobles were represented in much smaller numbers. Third, Service work experience from 2 to 5 years allowed working more professionally. Consequently, frames of the Russian Imperia in Siberia began to form more experienced employees during 1822–1917. However, 1–2 years was the average term of office. Fourthly, at the time the proportion of Siberian clerks with criminal record composed 7–8 per cent as figures was in the Central regions of the Russian Imperia.

  9. NODC Standard Product: Texas-Louisiana Shelf Circulation and Transport Processes Study: Current Meter, Meteorological Buoy, XBT/XSV/XCP/CTD/IES (NODC Accession 9700319)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This package contains current direction/velocity, water temperature, air temperature, salinity, and other data which were collected using current meter, CTD casts,...

  10. Vínculos com a Carreira e Produção Acadêmica: Comparando Docentes de IES Públicas e Privadas

    Directory of Open Access Journals (Sweden)

    Diva Ester Okazaki Rowe

    2010-11-01

    Full Text Available Research into the relationship between work and career involves two constructs - commitment and entrenchment, whose influence on performance have yet to be fully understood. The main goal of this study is to analyze the influences of the dimensions of links with the academic career of teaching in the contexts of public and private higher education in Brazil. This research is extensive in nature and cross-sectional. For data collection, a questionnaire which had previously been validated for the Brazilian context was applied containing a set of scales to measure career commitment and entrenchment. The links with the careers were measured by thescales proposed and validated by Carson and Bedeian (1994 and Carson, Carson and Bedeian (1995, while the performance of teachers includes points taken from their Curriculum Vitae of the Lattes Database, in accordance with the practice used by Oliveira (1998. We surveyed 635 teachers, whose data were submitted to descriptive analysis, factor analysis and structural equation modeling. The best fit model reveals that the more time and money teachers invest in their careers, the greater their academic performance will be. We also found differences in the influences of the two links to career in academic performance between private and public higher education establishments.

  11. Eficacitatea combaterii larvelor de Clostera anastomosis L. la ieșirea din hibernare [Treatment efficacy of Clostera anastomosis L. caterpillars control in postdormancy phase

    Directory of Open Access Journals (Sweden)

    Duduman Mihai-Leonard

    2015-12-01

    Full Text Available Clostera anastomosis is an important poplar and willow defoliator which, especially since 1950, caused important damages to intensive hybrid poplar crops in Europe and Asia. The need to reduce the loss caused by this insect, often led to radical control tactics, consisting in spraying chemical insecticides with low specificity and high impact on biodiversity. Other control methods (biological control had not the expected effect. Considering the above mentioned aspects and the fact that C. anastomosis overwinters as larvae, mainly in bark crevices of the stems of infested trees, it was tested the possibility of controlling this pest, by chemical control of the larvae, early in spring. There were designed two trials in lab and in field, in order to test the efficacy of 5 insecticides [Proteus (thiacloprid + deltamethrin, Ovipron (horticultural oil, Nuprid (imidacloprid, Confidor (imidacloprid and Karate Zeon (lambda-cyhalothin], sprayed directly on the stem of the poplar trees colonized with overwintering larvae nests. The treatment efficacy was assessed based on the survival rate of larvae after chemical spraying, by comparing it to the control samples. All surviving larvae were trapped in sticky barriers placed around the stems, above the sprayed area. Of the tested insecticides, the most efficient was Confidor, causing mortality of the 90.2 ± 1.8% of the larvae, significantly higher than the rest of the tested insecticides (Proteus, Ovipron, Nuprid. In field conditions, Confidor caused the decrease of the larvae population with 78.2 ± 7.4% for poplar clone AF2, and with 92.9 ± 6.4% for poplar clone AF8, and Karate Zeon caused 100% mortality. Control of the larvae in spring was efficient. It is a matter of course that this control method will have a lower environmental impact due to both the application moment (early spring, before poplars flush, and high control of the sprayed area (only the lower section of the infested tree stems. Successfull might be the application of mechanical control, by trapping the overwintering larvae in sticky barriers

  12. Optimization of MRR in EDM Process with Different Job Material i.e Stainless Steel and Cast Iron by Taguchi Method.

    Directory of Open Access Journals (Sweden)

    Dr. D.C. Roy

    2015-05-01

    Full Text Available Electro discharge machining (EDM has been recognized as an efficient method of producing dies and machining of hard material such as ceramics and high strength metal matrix composites for the modern metal industry (1. In this process the metal are remove through melting or vaporization of job metal by high frequency spark discharge. Although in this process the metal removal rate is lower than the other nonconventional machining process. But the dimensional accuracy is higher than the other process and more complex shape can be produce generally composite material are fascinated as thy exhibit exceptional mechanical and physical properties such as high strength, high hardness, and high density at elevated temperature. For this extra ordinary behavior it has wide range of application on the metal industries like aerospace, dies or mould making industries, automobiles industries etc. The metal removal rate (M.R.R. and surface smoothness not only depend on the selection of tool material also depend on the number of input parameter (such-input current, voltage, spindle speed, duty factor, dielectric medium, job metal property (conductivity ,hardness, strength, density etc.,machine condition and machining condition(machine performances, temperature, depth of cut or area of cut etc.. It is most difficult to select machining condition for optimal performances due to large number of parameters and inherent complexity of material removal mechanism taking place in EDM process. In the present work, the experiments were conducted using Taguchi L9 orthogonal approach, to ascertain the effect of EDM process parameters on material removal rate (MRR of stain less steel and cast iron by using tool material such copper and graphite.

  13. 41 CFR 301-11.17 - If my agency authorizes per diem reimbursement, will it reduce my M&IE allowance for a meal(s...

    Science.gov (United States)

    2010-07-01

    ... for a complimentary meal(s) provided by a hotel/motel? 301-11.17 Section 301-11.17 Public Contracts... complimentary meal(s) provided by a hotel/motel? No. A meal provided by a common carrier or a complimentary meal provided by a hotel/motel does not affect your per diem....

  14. ECHIPELE DE LUCRU AUTOCOORDONATE O SOLUŢIE MODERNĂ DE ORGANIZARE A UNITĂŢILOR OPERATIVE DIN INDUSTRIA OSPITALITĂŢII

    Directory of Open Access Journals (Sweden)

    Radu EMILIAN

    2006-06-01

    Full Text Available The industry of hospitality is one of the most valuable components of the third sector; in this context, already known, the solution of the companies whatever their category classification and type of establishment is to offer services that correspond to the promises made - therefore services that have a cost-price rapport in favor of the client. In the third sector and in hospitality business in particular, the human resources play a significant role in satisfying the clients and in offering a quality service that have been promised by the category of the hotel. The abilities of managers and their collaborators, the approach to utilization and organization of human resources can provide enterprises with important competitive advantages. In order to achieve this aim, the firms can experiment different ways to manage human resources. In this paper we will emphasis aspects of organizing the activity. We will underline the most important elements of an organization restructuring in hospitality industry: creation of auto coordinated working teams and design of horizontal organizational structures witch promote the interaction of employees from several departments.

  15. Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration.

    Directory of Open Access Journals (Sweden)

    Erna Morden

    Full Text Available HIV-exposed uninfected (HEU infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth within the first 28 weeks of life.This is a retrospective cohort based on routine clinical data from two South African PMTCT programmes. Data were collected between 2007 and 2013. Linear regression assessed factors affecting birth weight-for-age z-scores (WAZ while growth (longitudinal WAZ was assessed using mixed effects models.We assessed the growth of 2621 HEU infants (median birth WAZ was -0.65 (IQR -1.46; 0.0 and 51% were male. The feeding modalities practised were as follows: 0.5% exclusive breastfeeding, 7.9% breastfeeding with unknown exclusivity, 0.08% mixed breastfeeding and 89.2% formula feeding. Mothers with CD4 <200 cells/μl delivered infants with a lower birth WAZ (adjusted ß -0.253 [95% CI -0.043; -0.072], p = 0.006 compared to mothers with aCD4 ≥500 cells/μl. Similarly, mothers who did not receive antiretroviral drugs delivered infants with a lower birth WAZ (adjusted ß -0.39 [95% CI -0.67; -0.11], p = 0.007 compared to mothers who received antenatal antiretrovirals. Infants with a birth weight <2 500g (ß 0.070 [95% CI 0.061; 0.078], p <0.0001 experienced faster growth within the first 28 weeks of life compared to infants with a birth weight ≥2 500g. Infants with any breastfeeding exposure experienced slower longitudinal growth compared to formula fed infants (adjusted ß -0.012 [95% CI 0.021; -0.003], p = 0.011.Less severe maternal disease and the use of antiretrovirals positively impacts birth weight in this cohort of South African HEU infants. Formula feeding was common with breastfed infants experiencing marginally slower longitudinal growth.

  16. LUAREA COPILULUI DE LA PĂRINŢI – SANCŢIUNE SAU MĂSURĂ DE PROTECŢIE A MINORULUI?

    Directory of Open Access Journals (Sweden)

    Valentina CEBOTARI

    2016-03-01

    Full Text Available Conform legislaţiei în vigoare, părinţii sunt reprezentanţii legali ai copiilor lor şi sunt obligaţi să acţioneze în intere­sele acestora în raport cu toate persoanele fizice şi juridice, inclusiv cu autorităţile statului. Convenţia ONU privind drepturile copilului din 1989 subliniază, în Preambul, că familia este unitatea fundamentală a societăţii şi mediul natural pentru creşterea şi bunăstarea tuturor membrilor săi, în mod deosebit a copiilor. Studiile în acest domeniu au constatat că pentru dezvoltarea deplină şi armonioasă a personalităţii copilului el are nevoie de dragoste şi înţelegere în familie. Oriunde este posibil el trebuie să crească sub grija şi răspunderea părinţilor săi într-o atmosferă de afecţiune şi securitate morală şi materială, care îi va asigura o dezvoltare fizică normală, spirituală, intelectuală şi socială ca el să devină per­sonalitate. În cazurile în care părinţii nu-şi îndeplinesc obligaţiile sau abuzează de drepturi, organele de stat se implică şi iau măsurile necesare pentru ocrotirea minorilor, lipsindu-i pe părinţi de drepturi sau limitând aceste drepturi. TAKING THE CHILD FROM THE PARENTS: A SANCTION OR A MEASURE OF PROTECTION OF THE A MINOR?According to the legislation, parents are the legal representatives of their children and are obliged to act in their interest in relation with all of human persons and legal persons, including state authorities. UNO convention concerning rights of the child, dating1989, inpreamble highlights that family is a fundamental unit of the society and a natural environment for growing and welfare of all its members, especially of children. Studies in this field established that for full and harmonious development of the child personality he needs love and understanding in the family. Anywhere it is possible he should grow under care and responsibility of his parents, in a fondness, material and moral secured environment that will assure him a normal physical, spiritual, intellectual and social development in the way to become a personality. In case when parents do not execute their obligations or abuse of their rights, state bodies get involved and take the necessary measures for infant protection, depriving them of parental rights or limiting such one.

  17. Developing an Operational and Tactical Methodology for Incorporating Existing Technologies to Produce the Highest Probability of Detecting an Individual Wearing an IED

    Science.gov (United States)

    2010-06-01

    IEEE Xplore : http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=00 551835 McMillan, R. W., Milton Jr., O., Hetzler, M. C., Hyde, R. S., & Owens, W...R. (2000). Detection of concealed weapons using far-infrared bolometer arrays. Retrieved May 10, 2010, from IEEE Xplore : http...tools for the enhancement of concealed weapon detection. Retrieved March 5, 2010, from IEEE Xplore : http://ieeexplore.ieee.org/stamp/stamp.jsp?tp

  18. Reduction of Skin pH during Treatment for Palmoplantar Hyperhidrosis: A Conjecture on the Role of pH-Regulated Water Channel, i.e. Aquaporin

    Directory of Open Access Journals (Sweden)

    Kyoko Nakahigashi

    2013-04-01

    Full Text Available Primary palmoplantar hyperhidrosis (PPH is a disorder that involves excessive sweating on the palms and soles. Although the pathophysiology of PPH remains unknown, some treatments, including topical aluminum chloride (AC and tap water iontophoresis (TWI, are effective at suppressing the perspiration. Herein, we report the kinetics of the skin pH of two cases of PPH treated with AC and TWI. We found that the skin pH decreased in accordance with the reduction in sweating. This finding indicates that the reduction in sweating may be attributed to the reduction of skin pH in AC and TWI. Whether or not the pH-regulated function of aquaporin can explain this finding remains unknown.

  19. La inversión extranjera directa (IED) en Brasil y su impacto sobre la variables macroeconómicas del crecimiento, exportación y empleo

    OpenAIRE

    2016-01-01

    Tesis Doctoral leída en la Universidad Rey Juan Carlos de Madrid en 2016. Director de la Tesis: Dionisio de Haro Romero. Co-Directora: Doña Angelines Cano Linares La globalización de la economía mundial conduce a un mayor incremento en las transacciones financieras internacionales y, también, en las cantidades de inversión extranjera directa española en Brasil. Teniendo en cuenta este aumento de la inversión directa española en Brasil, se cree que hubo una complementariedad entre ...

  20. La atención al alumnado en el Departamento de Orientación del IES "Hoces del Duratón" : Integralidad y diversidad educativas

    OpenAIRE

    Ruiz de Santos, Consuelo

    2013-01-01

    En este proyecto se describe la atención al alumnado por parte del departamento de orientación de un centro rural. Entre las múltiples acciones hemos profundizado en dos aspectos: el apoyo al proceso de enseñanza-aprendizaje y la atención de dos alumnos en particular, uno con problemas de disciplina (posible TDAH) y otro con problemas de aprendizaje (Síndrome de Asperger). Además, hemos descrito nuestra participación en otros aspectos como el apoyo tutorial, la acogida al alumnado inmigrante,...