WorldWideScience

Sample records for biogzes raoanas ies

  1. D IE NEDERLANDSEGELOOFSBEL YDEN IS ASS IM BOL IE SEGE ...

    African Journals Online (AJOL)

    Test

    M aar aan die ander kant, as dit vir U blyk dat ons onskuldig is, wees ons dan n steun en n toevlug teen die geweld van onse vyande. W ant helaas, genadigste Heer, as mens alleen maar kan beskuldig terwyl aan die beskuldigde elke weg en middel van verdediging ontneem word, wie sal dan regverdig bevind word? W ie.

  2. The Yo-Yo IE2 test

    DEFF Research Database (Denmark)

    Krustrup, Peter; Bradley, Paul S; Christensen, Jesper F

    2015-01-01

    To examine the physical capacity and physiological response to the Yo-Yo Intermittent Endurance level 2 test (IE2) for untrained individuals and trained male soccer players, and to investigate the determinants of intense intermittent exercise performance.......To examine the physical capacity and physiological response to the Yo-Yo Intermittent Endurance level 2 test (IE2) for untrained individuals and trained male soccer players, and to investigate the determinants of intense intermittent exercise performance....

  3. P.J. Ie Roux·

    African Journals Online (AJOL)

    Ses groepe van 45 volwasse Karakoelooie is met 40 mg MAP sponse vir 15 dae behandel. Vyf van die groepe het 400 IE DMS twee dae voor sponsonttrekking ontvang. AI die ooie is gepaar 12 uur na aanvang van oestrus en weer 9 tot 10 uur later. ofkunsmatig. Of deur middel van natuurlike paring. Een van die groepe is ...

  4. Local intelligent electronic device (IED) rendering templates over limited bandwidth communication link to manage remote IED

    Science.gov (United States)

    Bradetich, Ryan; Dearien, Jason A; Grussling, Barry Jakob; Remaley, Gavin

    2013-11-05

    The present disclosure provides systems and methods for remote device management. According to various embodiments, a local intelligent electronic device (IED) may be in communication with a remote IED via a limited bandwidth communication link, such as a serial link. The limited bandwidth communication link may not support traditional remote management interfaces. According to one embodiment, a local IED may present an operator with a management interface for a remote IED by rendering locally stored templates. The local IED may render the locally stored templates using sparse data obtained from the remote IED. According to various embodiments, the management interface may be a web client interface and/or an HTML interface. The bandwidth required to present a remote management interface may be significantly reduced by rendering locally stored templates rather than requesting an entire management interface from the remote IED. According to various embodiments, an IED may comprise an encryption transceiver.

  5. IE Bulletin No. 79-01: Environmental qualification of Class IE equipment

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The intent of IE Circular 78-08 was to highlight to all licensees important lessons learned from environmental qualification deficiencies reported by individual licensees. In this regard, licensees were requested to examine installed safety-related electrical equipment and determine that proper documentation existed which provided assurance that this equipment would function under postulated accident conditions. The intent of this Bulletin is to raise the threshold of IE Circular 78-08 to the level of a Bulletin; i.e., action requiring a licensee response. Inspections conducted to date by the NRC of licensees' activities in response to IE Circular 78-08 have identified one component which licensees have found to be unqualified for service within the LOCA environment. Specifically, unqualified stem mounted limit switches (SMLS), other than those identified in previously issued IE Bulletin 78-04, were found to be installed on safety-related valves inside containment at both Duane Arnold and Quad Cities 1 and 2 Nuclear Generating Stations. According to the manufacturer, these switches are designed only for general purpose applications and are not considered suitable devices for service in the LOCA environment. Consequently, switches are being replaced at the above power plants with qualified components

  6. The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting

    Energy Technology Data Exchange (ETDEWEB)

    Hornig, Julia; Choi, K. Yeon; McGregor, Alistair, E-mail: mcgregor@medicine.tamhsc.edu

    2017-04-15

    Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed direct interaction with ND10 components by immunoprecipitation unlike IE2. Additionally, IE1 protein disrupted ND10 bodies. IE1 mutagenesis mapped the nuclear localization signal to the C-terminus and identified the core domain for gpPML interaction. Individual knockout of GPCMV GP122 or GP123 (IE2 and IE1 unique exons respectively) was lethal to the virus. However, an IE1 mutant (codons 234–474 deleted), was viable with attenuated viral growth kinetics and increased susceptibility to type I interferon (IFN-I). In HCMV, the IE proteins are important T cell target antigens. Consequently, characterization of the homologs in GPCMV provides a basis for their evaluation in candidate vaccines against congenital infection.

  7. The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting

    Science.gov (United States)

    Hornig, Julia; Choi, K. Yeon; McGregor, Alistair

    2017-01-01

    Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed direct interaction with ND10 components by immunoprecipitation unlike IE2. Additionally, IE1 protein disrupted ND10 bodies. IE1 mutagenesis mapped the nuclear localization signal to the C-terminus and identified the core domain for gpPML interaction. Individual knockout of GPCMV GP122 or GP123 (IE2 and IE1 unique exons respectively) was lethal to the virus. However, an IE1 mutant (codons 234–474 deleted), was viable with attenuated viral growth kinetics and increased susceptibility to type I interferon (IFN-I). In HCMV, the IE proteins are important T cell target antigens. Consequently, characterization of the homologs in GPCMV provides a basis for their evaluation in candidate vaccines against congenital infection. PMID:28189970

  8. Riflessioni sull’evoluzione del prostorečie russo

    Directory of Open Access Journals (Sweden)

    Valentina Benigni

    2005-12-01

    Full Text Available Some Remarks On the Development of Russian Prostorečie The paper provides a brief outline of Russian prostorečie (urban popular language, which is the supraregional language variety spoken by uneducated or half educated urban population, that doesn’t know the norms of standard language. Phonetic, morphosyntactic and lexical peculiarities of this language variety are illustrated by means of a real sample of Russian prostorečie: a letter written by an 80-year-old woman. The article also focuses attention on the development of a new prostorečie, which, with respect to old prostorečie, is characterized exclusively on lexical plane, and is the source by which slang and professional elements penetrate into the standard language.

  9. La Inversion Extranjera Directa (IED, teorias y practicas.

    Directory of Open Access Journals (Sweden)

    De la Garza, U.

    2005-01-01

    Full Text Available En éste articulo, analizaremos algunas de las principales teorías relacionadas con la IED. Se destacarán principalmente los aportes teóricos en cuanto a posibles efectos positivos y negativos de la llegada de IED a economías receptoras. Al mismo tiempo, se tratará de resaltar y justificar la importancia de la llegada de nuevas inversiones a países en desarrollo como México, destacando los principales factores que propician la llegada de IED en países en desarrollo.

  10. Genetics Home Reference: hereditary sensory and autonomic neuropathy type IE

    Science.gov (United States)

    ... where needed and connect with each other, and neuron survival. DNMT1 gene mutations that cause HSAN IE affect the enzyme's methylation function, resulting in abnormalities in the maintenance of the ...

  11. Human-technology interaction for standoff IED detection

    Science.gov (United States)

    Zhang, Evan; Zou, Yiyang; Zachrich, Liping; Fulton, Jack

    2011-03-01

    IEDs kill our soldiers and innocent people every day. Lessons learned from Iraq and Afghanistan clearly indicated that IEDs cannot be detected/defeated by technology alone; human-technology interaction must be engaged. In most cases, eye is the best detector, brain is the best computer, and technologies are tools, they must be used by human being properly then can achieve full functionality. In this paper, a UV Raman/fluorescence, CCD and LWIR 3 sensor fusion system for standoff IED detection and a handheld fusion system for close range IED detection are developed and demonstrated. We must train solders using their eyes or CCD/LWIR cameras to do wide area search while on the move to find small suspected area first then use the spectrometer because the laser spot is too small, to scan a one-mile long and 2-meter wide road needs 185 days although our fusion system can detect the IED in 30m with 1s interrogating time. Even if the small suspected area (e.g., 0.5mx0.5m) is found, human eyes still cannot detect the IED, soldiers must use or interact with the technology - laser based spectrometer to scan the area then they are able to detect and identify the IED in 10 minutes not 185 days. Therefore, the human-technology interaction approach will be the best solution for IED detection.

  12. JRC-IE's research of safety of Gen IV systems

    International Nuclear Information System (INIS)

    Tsige-Tamirat, H.; Ranguelova, V.; Feutterer, M.; Ammirabile, L.; Carlsson, J.; D'Agata, E.; Laurie, M.; Magallon, D.

    2010-01-01

    The Institute for Energy (IE), one of the seven scientific Institutes of the Joint Research Centre (JRC) of the European Commission, has the mission to provide scientific and technical support for the conception, development, implementation and monitoring of community policies related to energy. To accomplish its mission, IE performs research in the areas of renewable energies, safety and sustainability of nuclear energy for current and future reactor systems, energy technic/economic assessment, and security of energy supply. The Generation IV International Forum (GIF) is a cooperative international endeavour organized to carry out R and D needed to establish the feasibility and performance capabilities of the next generation nuclear energy systems and support the progress towards their realization. The EU, represented by EURATOM and with the JRC as implementing agent, is working together with other GIF partners to perform pre-competitive R and D on key technologies to be implemented in future nuclear systems. IE is engaged in experimental research, simulation and modeling, scientific, feasibility and engineering studies on innovative nuclear reactor systems needed to support the EURATOM contribution to GEN IV initiative, in particular in assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions and knowledge management and preservation. IE's research activities on Generation IV reactor systems are focused on the assessment of the potential of such systems to meet long term EU energy needs with respect to economical advantages, enhanced safety, sustainability, and proliferation resistance. IE participates in international collaborations and has bilateral research cooperation both with European and non-European partners. This paper gives an overview of IE's current research activities on the Gen IV reactor systems related to safety. (authors)

  13. Inductive energy store (IES) technology for multi-terrawatt generators

    International Nuclear Information System (INIS)

    Sincerny, P.S.; Ashby, S.R.; Childers, F.K.; Deeney, C.; Kortbawi, D.; Goyer, J.R.; Riordan, J.C.; Roth, I.S.; Stallings, C.; Schlitt, L.

    1993-01-01

    An IES pulsed power machine has been built at Physics International Company that serves as a prototype demonstration of IES technology that is scaleable to very large TW generators. The prototype module utilizes inductive store opening switch technology for the final stage of pulse compression and is capable of driving both electron beam Bremsstrahlung loads or imploding plasma loads. Each module consists of a fast discharge Marx driving a water dielectric transfer capacitor which is command triggered to drive the inductive store section of the machine. The inductive store is discharged into the load using a plasma erosion opening switch. Data demonstrating 22% efficient operation into an electron beam diode load are presented. The system issues addressing the combining of these modules into a very large pulsed power machine are discussed

  14. Automation of IED Threat Emplacement for Training Scenarios

    Science.gov (United States)

    2012-03-01

    pendant le processus d’analyse des exigences ont été prototypés. Importance : En modélisant les scénarios d’attaque par IED possibles en fonction des... bridges – The ontology engine would provide “roads” as the feature layer/class, “3m” and the narrowed width and “buildings” and “ bridges ” as the feature

  15. Wireless Sensor Networks for Detection of IED Emplacement

    Science.gov (United States)

    2009-06-01

    unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Abstract We are investigating the use of wireless nonimaging -sensor...networks for the difficult problem of detection of suspicious behavior related to IED emplacement. Hardware for surveillance by nonimaging -sensor networks...with people crossing a live sensor network. We conclude that nonimaging -sensor networks can detect a variety of suspicious behavior, but

  16. SUPERNOVA 2003ie WAS LIKELY A FAINT TYPE IIP EVENT

    Energy Technology Data Exchange (ETDEWEB)

    Arcavi, Iair; Gal-Yam, Avishay [Department of Particle Physics and Astrophysics, The Weizmann Institute of Science, Rehovot 76100 (Israel); Sergeev, Sergey G., E-mail: iair.arcavi@weizmann.ac.il [Crimean Astrophysical Observatory, P/O Nauchny, Crimea 98409 (Ukraine)

    2013-04-15

    We present new photometric observations of supernova (SN) 2003ie starting one month before discovery, obtained serendipitously while observing its host galaxy. With only a weak upper limit derived on the mass of its progenitor (<25 M{sub Sun }) from previous pre-explosion studies, this event could be a potential exception to the ''red supergiant (RSG) problem'' (the lack of high-mass RSGs exploding as Type IIP SNe). However, this is true only if SN2003ie was a Type IIP event, something which has never been determined. Using recently derived core-collapse SN light-curve templates, as well as by comparison to other known SNe, we find that SN2003ie was indeed a likely Type IIP event. However, with a plateau magnitude of {approx} - 15.5 mag, it is found to be a member of the faint Type IIP class. Previous members of this class have been shown to arise from relatively low-mass progenitors (<12 M{sub Sun }). It therefore seems unlikely that this SN had a massive RSG progenitor. The use of core-collapse SN light-curve templates is shown to be helpful in classifying SNe with sparse coverage. These templates are likely to become more robust as large homogeneous samples of core-collapse events are collected.

  17. Irradiation effects test series test IE-1 test results report

    International Nuclear Information System (INIS)

    Quapp, W.J.; Allison, C.M.; Farrar, L.C.; Mehner, A.S.

    1977-03-01

    The report describes the results of the first programmatic test in the Nuclear Regulatory Commission Irradiation Effects Test Series. This test (IE-1) used four 0.97m long PWR-type fuel rods fabricated from previously irradiated Saxton fuel. The objectives of this test were to evaluate the effect of fuel pellet density on pellet-cladding interaction during a power ramp and to evaluate the influence of the irradiated state of the fuel and cladding on rod behavior during film boiling operation. Data are presented on the behavior of irradiated fuel rods during steady-state operation, a power ramp, and film boiling operation. The effects of as-fabricated gap size, as-fabricated fuel density, rod power, and power ramp rate on pellet-cladding interaction are discussed. Test data are compared with FRAP-T2 computer model predictions, and comments on the consequences of sustained film boiling operation on irradiated fuel rod behavior are provided

  18. Irradiation Effects Test Series: Test IE-3. Test results report

    International Nuclear Information System (INIS)

    Farrar, L.C.; Allison, C.M.; Croucher, D.W.; Ploger, S.A.

    1977-10-01

    The objectives of the test reported were to: (a) determine the behavior of irradiated fuel rods subjected to a rapid power increase during which the possibility of a pellet-cladding mechanical interaction failure is enhanced and (b) determine the behavior of these fuel rods during film boiling following this rapid power increase. Test IE-3 used four 0.97-m long pressurized water reactor type fuel rods fabricated from previously irradiated fuel. The fuel rods were subjected to a preconditioning period, followed by a power ramp to 69 kW/m at a coolant mass flux of 4920 kg/s-m 2 . After a flow reduction to 2120 kg/s-m 2 , film boiling occurred on the fuel rods. One rod failed approximately 45 seconds after the reactor was shut down as a result of cladding embrittlement due to extensive cladding oxidation. Data are presented on the behavior of these irradiated fuel rods during steady-state operation, the power ramp, and film boiling operation. The effects of a power ramp and power ramp rates on pellet-cladding interaction are discussed. Test data are compared with FRAP-T3 computer model calculations and data from a previous Irradiation Effects test in which four irradiated fuel rods of a similar design were tested. Test IE-3 results indicate that the irradiated state of the fuel rods did not significantly affect fuel rod behavior during normal, abnormal (power ramp of 20 kW/m per minute), and accident (film boiling) conditions

  19. PECULIARITIES OF CONSTRUCTION OF INSTITUTIONS OF SECONDARY EDUCATION IN MOSCOW IN THE 1920IES AND 1930IES

    Directory of Open Access Journals (Sweden)

    Byzova Ol'ga Mikhaylovna

    2012-10-01

    Full Text Available Actions aimed at the generality of elementary education in the course of the period days of the industrialization and cultural revolution in the USSR is under discussion in the proposed paper. On the basis of the archived documents, organization of construction of school buildings in Moscow in the 20ies and 30ies of the 20th century is analyzed. It is noteworthy that industrialization in the periods of the first, second and third five-year plans reshaped the country and Moscow as its capital. Former suburbs turned into large industrial areas that had giant factories and housing built around them to accommodate workers. Thus, the population of Moscow grew in numbers. The need for competent staff facilitated construction of new schools. Peculiarities of school construction in Moscow within the first five-year plan are considered in article on the basis of a school building in Likhobory in 1932. The school building design, work progress, assembly and interior, deadlines and problems of construction are specified. It is noteworthy that, despite any difficulties, 19 new school buildings were completed in Moscow in the years of the first five-year plan. Classes were organized according to the principle of two shifts to implement the general education programme in 1932.

  20. Postirradiation examination results for the Irradiation Effects Test IE-5

    International Nuclear Information System (INIS)

    Cook, T.F.; Ploger, S.A.; Hobbins, R.R.

    1978-03-01

    The results are presented of the postirradiation examination of four pressurized water reactor type fuel rods which were tested in-pile under a fast power ramp and film boiling operation during Irradiation Effects (IE) Test 5. The major objectives of this test were to evaluate the effects of simulated fission products on fuel rod behavior during a fast power ramp, to determine the effects of high initial internal pressure on a fuel rod during film boiling, and to assess fuel rod property changes that occur during film boiling in a fuel rod with previously irradiated cladding. The overall condition of the rods and changes that occurred in fuel and cladding as a result of the power ramp and film boiling operation, as determined from the postirradiation examination, are reported and analyzed. Effects of the simulated fission products on fuel rod behavior during a power ramp are discussed. The effect of high internal pressure on rod behavior during film boiling is evaluated. Cladding temperatures are estimated at various axial and circumferential locations. Cladding embrittlement by oxidation is also assessed

  1. Irradiation effects test series, test IE-5. Test results report

    International Nuclear Information System (INIS)

    Croucher, D.W.; Yackle, T.R.; Allison, C.M.; Ploger, S.A.

    1978-01-01

    Test IE-5, conducted in the Power Burst Facility at the Idaho National Engineering Laboratory, employed three 0.97-m long pressurized water reactor type fuel rods, fabricated from previously irradiated zircaloy-4 cladding and one similar rod fabricated from unirradiated cladding. The objectives of the test were to evaluate the influence of simulated fission products, cladding irradiation damage, and fuel rod internal pressure on pellet-cladding interaction during a power ramp and on fuel rod behavior during film boiling operation. The four rods were subjected to a preconditioning period, a power ramp to an average fuel rod peak power of 65 kW/m, and steady state operation for one hour at a coolant mass flux of 4880 kg/s-m 2 for each rod. After a flow reduction to 1800 kg/s-m 2 , film boiling occurred on one rod. Additional flow reductions to 970 kg/s-m 2 produced film boiling on the three remaining fuel rods. Maximum time in film boiling was 80s. The rod having the highest initial internal pressure (8.3 MPa) failed 10s after the onset of film boiling. A second rod failed about 90s after reactor shutdown. The report contains a description of the experiment, the test conduct, test results, and results from the preliminary postirradiation examination. Calculations using a transient fuel rod behavior code are compared with the test results

  2. Irradiation Effects Test Series: Test IE-2. Test results report

    International Nuclear Information System (INIS)

    Allison, C.M.; Croucher, D.W.; Ploger, S.A.; Mehner, A.S.

    1977-08-01

    The report describes the results of a test using four 0.97-m long PWR-type fuel rods with differences in diametral gap and cladding irradiation. The objective of this test was to provide information about the effects of these differences on fuel rod behavior during quasi-equilibrium and film boiling operation. The fuel rods were subjected to a series of preconditioning power cycles of less than 30 kW/m. Rod powers were then increased to 68 kW/m at a coolant mass flux of 4900 kg/s-m 2 . After one hour at 68 kW/m, a power-cooling-mismatch sequence was initiated by a flow reduction at constant power. At a flow of 2550 kg/s-m 2 , the onset of film boiling occurred on one rod, Rod IE-011. An additional flow reduction to 2245 kg/s-m 2 caused the onset of film boiling on the remaining three rods. Data are presented on the behavior of fuel rods during quasiequilibrium and during film boiling operation. The effects of initial gap size, cladding irradiation, rod power cycling, a rapid power increase, and sustained film boiling are discussed. These discussions are based on measured test data, preliminary postirradiation examination results, and comparisons of results with FRAP-T3 computer model calculations

  3. Environmental Project of I.E.S. Antoni Maura

    Science.gov (United States)

    Crespi Salom, Pere

    2010-05-01

    Environmental Project of I.E.S. Antoni Maura Author(s): Pere Crespí i Salom Teacher of Department of Biology and Geology and Environmental Coordinator (2009-2010) from I.E.S. Antoni Maura . Mallorca. Illes Balears. Spain Teachers participating in the project : Myriam Fuentes Milani, Olga Ballester Nebot, Antoni Salom Ruiz, Julio René Loayza Casanova, Puy Aguirre Rémirez, Yolanda Martínez Laserna, Jaume Puppo Lama, Carme Arrom , Dolors Aguiló Segura, Marga Ordinas Boter, Angel Fernàndez Albertí , Immaculada Suau López, Antònia Florit Torrandell, Isabel Mateu Arcos, Román Piña Valls i Pere Crespí Salom. Our institute takes part since 2004 in adapting environmentally the schools in the Balearics which consists of developing activities which aim is that both teachers and students acquire habits so as to apply to their ordinary lives though different participative commissions ( 10-15 teachers): 1st commission: recycling and reusing materials. Enough bins in the classrooms and floors: yellow for plastic, blue for paper, and green for the other. We tend to use recycled materials in different celebrations such as Carnival, Christmas, Saint Jordi and Environmental day. We also organise workshops for the teachers to develop afterwards with the students and nature of environmental exposures. 2nd commission: Scatter information ( MonMaura, Maurifull, Green window and website).Throughout different means we inform the teachers and students about all the school activities and where to consult.( www.iesantonimaura.net, Playful area , environmental project ). 3rd commission: Reusing text books.( there is a students service of borrowing books and giving them back at the end of the school year if the book is in good use.) 4th commission: Improving the school surroundings, the back garden and garden with native plants. Department of Biology and Geology is responsible for caring for an organic garden and in turn improve the center's garden with native plants within the

  4. The Role of Solidarity(-ies) in Rare Diseases Research.

    Science.gov (United States)

    Mascalzoni, Deborah; Petrini, Carlo; Taruscio, Domenica; Gainotti, Sabina

    2017-01-01

    reciprocity (not one sided). The context of solidarity(ies) provides a solid base for framing the research endeavor as collectively valuable, not only for possible results of the research, but as intrinsic valid societal practice. This paper tries to draw the lessons on solidarity that we can derive from the RD world where "solidarities" have been part of the game for long time and are declined on many different levels.

  5. An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity.

    Science.gov (United States)

    Wan, Xinyue; Yin, Jieyun; Foreman, Robert; Chen, Jiande D Z

    2017-12-01

    This paper aims to optimize stimulation parameters and durations for intestinal electrical stimulation (IES) and to explore the effects and mechanisms of chronic IES with optimized methodology in obesity rats. Sixteen diet-induced obese (DIO) rats were tested for food intake with four different sets of IES parameters each lasting 1 week. Then, another 12 DIO rats were used to test the effect of IES on food intake with different stimulation durations. Finally, 16 DIO rats were treated with IES or sham-IES for 4 weeks. Meal patterns, food intake, and body weight were observed. Mechanisms involving gastrointestinal motility, ghrelin, and glucagon-like peptide-1 (GLP-1) were studied. (1) Acute IES with different parameters showed different inhibitory effects on food intake, and the most effective parameters were 0.6 s on, 0.9 s off, 80 Hz, 2 ms, and 4 mA with which 26.3% decrease in food intake was noted (p fasting and postprandial plasma levels of GLP-1 but not ghrelin. Twelve-hour daily IES using optimized stimulation parameters reduces food intake and body weight in DIO rats by altering gastrointestinal motility and GLP-1. The IES methodology derived in this study may have a therapeutic potential for obesity.

  6. Hittite huelpi- “Young, tender, fresh” and ie +Hulp-, +Hlup-

    Directory of Open Access Journals (Sweden)

    Metka Furlan

    1984-12-01

    Full Text Available The following contribution offers a new etymology of the Hittite term huelpi- which can through  IE root +Huelep- be related to IE +Hulp-, +Hlup- »fox, wolf, cat«.The relation indicates that the old expression for naming offerings to the gods is hidden in the IE forms +Hulp-, +Hlup-.

  7. Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against HCMV proteins IE1 and IE2.

    Science.gov (United States)

    Braendstrup, Peter; Mortensen, Bo Kok; Justesen, Sune; Osterby, Thomas; Rasmussen, Michael; Hansen, Andreas Martin; Christiansen, Claus Bohn; Hansen, Morten Bagge; Nielsen, Morten; Vindeløv, Lars; Buus, Søren; Stryhn, Anette

    2014-01-01

    Human cytomegalovirus (HCMV) is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants. Moreover, it has recently been suggested that HCMV may promote tumor development. Both CD4+ and CD8+ T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8+ T cell responses against the pp65 phosphoprotein. In this study, we have focused on CD4+ and CD8+ T cell responses against the immediate early 1 and 2 proteins (IE1 and IE2). Using overlapping peptides spanning the entire IE1 and IE2 sequences, peripheral blood mononuclear cells from 16 healthy, HLA-typed, donors were screened by ex vivo IFN-γ ELISpot and in vitro intracellular cytokine secretion assays. The specificities of CD4+ and CD8+ T cell responses were identified and validated by HLA class II and I tetramers, respectively. Eighty-one CD4+ and 44 CD8+ T cell responses were identified representing at least seven different CD4 epitopes and 14 CD8 epitopes restricted by seven and 11 different HLA class II and I molecules, respectively, in total covering 91 and 98% of the Caucasian population, respectively. Presented in the context of several different HLA class II molecules, two epitope areas in IE1 and IE2 were recognized in about half of the analyzed donors. These data may be used to design a versatile anti-HCMV vaccine and/or immunotherapy strategy.

  8. Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against HCMV proteins IE1 and IE2.

    Directory of Open Access Journals (Sweden)

    Peter Braendstrup

    Full Text Available Human cytomegalovirus (HCMV is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants. Moreover, it has recently been suggested that HCMV may promote tumor development. Both CD4+ and CD8+ T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8+ T cell responses against the pp65 phosphoprotein. In this study, we have focused on CD4+ and CD8+ T cell responses against the immediate early 1 and 2 proteins (IE1 and IE2. Using overlapping peptides spanning the entire IE1 and IE2 sequences, peripheral blood mononuclear cells from 16 healthy, HLA-typed, donors were screened by ex vivo IFN-γ ELISpot and in vitro intracellular cytokine secretion assays. The specificities of CD4+ and CD8+ T cell responses were identified and validated by HLA class II and I tetramers, respectively. Eighty-one CD4+ and 44 CD8+ T cell responses were identified representing at least seven different CD4 epitopes and 14 CD8 epitopes restricted by seven and 11 different HLA class II and I molecules, respectively, in total covering 91 and 98% of the Caucasian population, respectively. Presented in the context of several different HLA class II molecules, two epitope areas in IE1 and IE2 were recognized in about half of the analyzed donors. These data may be used to design a versatile anti-HCMV vaccine and/or immunotherapy strategy.

  9. A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector

    International Nuclear Information System (INIS)

    Wang, Z.; Zhou, W.; Srivastava, T.; La Rosa, C.; Mandarino, A.; Forman, S.J.; Zaia, J.A.; Britt, W.J.; Diamond, D.J.

    2008-01-01

    A therapeutic CMV vaccine incorporating an antigenic repertoire capable of eliciting a cellular immune response has yet to be successfully implemented for patients who already have acquired an infection. To address this problem, we have developed a vaccine candidate derived from modified vaccinia Ankara (MVA) that expresses three immunodominant antigens (pp65, IE1, IE2) from CMV. The novelty of this vaccine is the fusion of two adjacent exons from the immediate-early region of CMV, their successful expression in MVA, and robust immunogenicity in both primary and memory response models. Evaluation of the immunogenicity of the viral vaccine in mouse models shows that it can stimulate primary immunity against all three antigens in both the CD4 + and CD8 + T cell subsets. Evaluation of human PBMC from healthy CMV-positive donors or patients within 6 months of receiving hematopoietic cell transplant shows robust stimulation of existing CMV-specific CD4 + and CD8 + T cell subsets

  10. A novel interactive educational system in the operating room--the IE system.

    Science.gov (United States)

    Nakayama, Takayuki; Numao, Noboru; Yoshida, Soichiro; Ishioka, Junichiro; Matsuoka, Yoh; Saito, Kazutaka; Fujii, Yasuhisa; Kihara, Kazunori

    2016-02-02

    The shortage of surgeon is one of the serious problems in Japan. To solve the problem, various efforts have been undertaken to improve surgical education and training. However, appropriate teaching methods in the operating room have not been well established. The aim of this study is to assess the utility of a novel interactive educational (IE) system for surgical education on urologic surgeries in the operating room. A total of 20 Japanese medical students were educated on urologic surgery using the IE system in the operating room. The IE system consists of two parts. The first is three-dimensional (3D) magnified vision of the operative field using a 3D head-mounted display and a 3D endoscope. The second is interactive educative communication between medical students and surgeons using a small-sized wireless communication device. The satisfaction level with the IE system and the physical burden on medical students was examined via questionnaire. All students utilized the IE system in urologic surgery and responded to the survey. Most students were satisfied with the IE system. They also felt more welcomed by the surgeon when using the IE system than when not using it. No major unpleasant symptoms were observed but five students (25 %) experienced mild eye fatigue as a result of viewing the medical images. The IE system has the potential to motivate students to become interested in surgery and could be an efficient method of surgical education in the operating room.

  11. 41 CFR 301-11.102 - What is the applicable M&IE rate?

    Science.gov (United States)

    2010-07-01

    ... 24 hours or more, and you are traveling to a new TDY site or stopover point at midnight The M&IE rate applicable to the new TDY site or stopover point. Travel is 24 hours or more, and you are returning to your...&IE rate? 301-11.102 Section 301-11.102 Public Contracts and Property Management Federal Travel...

  12. Characterization of Asian Corn Borer Resistance to Bt Toxin Cry1Ie

    Directory of Open Access Journals (Sweden)

    Yueqin Wang

    2017-06-01

    Full Text Available A strain of the Asian corn borer (ACB, Ostrinia furnacalis (Guenée, has evolved >800-fold resistance to Cry1Ie (ACB-IeR after 49 generations of selection. The inheritance pattern of resistance to Cry1Ie in ACB-IeR strain and its cross-resistance to other Bt toxins were determined through bioassay by exposing neonates from genetic-crosses to toxins incorporated into the diet. The response of progenies from reciprocal F1 crosses were similar (LC50s: 76.07 vs. 74.32 μg/g, which suggested the resistance was autosomal. The effective dominance (h decreased as concentration of Cry1Ie increased. h was nearly recessive or incompletely recessive on Cry1Ie maize leaf tissue (h = 0.02, but nearly dominant or incompletely dominant (h = 0.98 on Cry1Ie maize silk. Bioassay of the backcross suggested that the resistance was controlled by more than one locus. In addition, the resistant strain did not perform cross-resistance to Cry1Ab (0.8-fold, Cry1Ac (0.8-fold, Cry1F (0.9-fold, and Cry1Ah (1.0-fold. The present study not only offers the manifestation for resistance management, but also recommends that Cry1Ie will be an appropriate candidate for expression with Cry1Ab, Cry1Ac, Cry1F, or Cry1Ah for the development of Bt maize.

  13. Characterization of Asian Corn Borer Resistance to Bt Toxin Cry1Ie.

    Science.gov (United States)

    Wang, Yueqin; Yang, Jing; Quan, Yudong; Wang, Zhenying; Cai, Wanzhi; He, Kanglai

    2017-06-07

    A strain of the Asian corn borer (ACB), Ostrinia furnacalis (Guenée), has evolved >800-fold resistance to Cry1Ie (ACB-IeR) after 49 generations of selection. The inheritance pattern of resistance to Cry1Ie in ACB-IeR strain and its cross-resistance to other Bt toxins were determined through bioassay by exposing neonates from genetic-crosses to toxins incorporated into the diet. The response of progenies from reciprocal F₁ crosses were similar (LC 50 s: 76.07 vs. 74.32 μg/g), which suggested the resistance was autosomal. The effective dominance ( h ) decreased as concentration of Cry1Ie increased. h was nearly recessive or incompletely recessive on Cry1Ie maize leaf tissue ( h = 0.02), but nearly dominant or incompletely dominant ( h = 0.98) on Cry1Ie maize silk. Bioassay of the backcross suggested that the resistance was controlled by more than one locus. In addition, the resistant strain did not perform cross-resistance to Cry1Ab (0.8-fold), Cry1Ac (0.8-fold), Cry1F (0.9-fold), and Cry1Ah (1.0-fold). The present study not only offers the manifestation for resistance management, but also recommends that Cry1Ie will be an appropriate candidate for expression with Cry1Ab, Cry1Ac, Cry1F, or Cry1Ah for the development of Bt maize.

  14. Utilizing the Intercultural Effectiveness Scale (IES) to Enhance International Student Travel

    Science.gov (United States)

    Bates, Alicia; Rehal, Dalia Atef

    2017-01-01

    This paper highlights how one institution used the International Effectiveness Scale (IES) to support intercultural exploration and development for short-term undergraduate travel programs. Authors discuss utilization of the IES to explore students' intercultural development, how it can be applied to create an individualized action plan, and how…

  15. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Wang, Weimin; Zhang, Jian; Mendon, Vrushali V.; Athalye, Rahul A.; Xie, YuLong; Hart, Reid; Goel, Supriya

    2014-03-01

    This report provides a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IES Standard 90.1-2010.

  16. ZentyES : Gestión de la red de un IES con Zentyal

    OpenAIRE

    Bermejo Sánchez, Guadalupe

    2012-01-01

    Solución para centralizar los servicios básicos (DNS, DHCP, FTP, web) e implementar los niveles de seguridad adecuados de la red de un IES donde se impartan ciclos formativos que necesiten aulas de informática. La documentación presentada permitirá que la solución implementada sirva como modelo a cualquier IES de características similares. Solució per centralitzar els serveis bàsics (DNS, DHCP, FTP, web) i implementar els nivells de seguretat adequats de la xarxa d'un IES on s'imparteixen ...

  17. New-onset Intermittent Explosive Disorder (IED; metabolic and clinical correlates: Case report

    Directory of Open Access Journals (Sweden)

    Giuseppina Selene Spina

    2017-08-01

    Full Text Available This paper presents the correlation between Intermittent Explosive Disorder (IED, listed in the domain of Disruptive, Impulse-Control and Conduct Disorders in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5, and metabolic alterations. A 64-years-old man with no previous history of major psychiatric disorders, presenting an onset of IED almost concomitant with the diagnosis of diabetes mellitus and dyslipidemia, is assessed upon a clinical and neuropsychological evaluation. Authors emphasize the influence of metabolic alterations and liver disease in the manifestation of impulsive aggression and violent behaviour, suggesting a multidisciplinary approach of those patients who present IED and concomitant metabolic alterations.

  18. Preventing an Improvised Explosive Device (IED) Terror Campaign in the United States

    National Research Council Canada - National Science Library

    Wehri, Matthew T

    2007-01-01

    .... This thesis will propose how to prevent a domestic IED terror campaign by utilizing the intelligence triggers indications and warnings and open source intelligence as well as placing increased...

  19. An accelerated hybrid TLM-IE method for the investigation of shielding effectiveness

    Directory of Open Access Journals (Sweden)

    N. Fichtner

    2010-09-01

    Full Text Available A hybrid numerical technique combining time-domain integral equations (TD-IE with the transmission line matrix (TLM method is presented for the efficient modeling of transient wave phenomena. This hybrid method allows the full-wave modeling of circuits in the time-domain as well as the electromagnetic coupling of remote TLM subdomains using integral equations (IE. By using the integral equations the space between the TLM subdomains is not discretized and consequently doesn't contribute to the computational effort. The cost for the evaluation of the time-domain integral equations (TD-IE is further reduced using a suitable plane-wave representation of the source terms. The hybrid TD-IE/TLM method is applied in the computation of the shielding effectiveness (SE of metallic enclosures.

  20. The Sixth International Conference on Intelligent Environments (IE 10): A Report

    OpenAIRE

    Callaghan, Vic; Egerton, Simon; Kameas, Achilles; Satoh, Ichiro

    2011-01-01

    The 6th International Conference on Intelligent Environments (IE10) was held July 19-21 at the Sunway campus of Monash University, Kuala Lumpur, Malaysia. This article presents a report of the conference.

  1. “Virtual IED sensor” at an rf-biased electrode in low-pressure plasma

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanova, M. A.; Zyryanov, S. M. [Skobeltsyn Institute of Nuclear Physics, Moscow State University, SINP MSU, Moscow (Russian Federation); Faculty of Physics, Moscow State University, MSU, Moscow (Russian Federation); Lopaev, D. V.; Rakhimov, A. T. [Skobeltsyn Institute of Nuclear Physics, Moscow State University, SINP MSU, Moscow (Russian Federation)

    2016-07-15

    Energy distribution and the flux of the ions coming on a surface are considered as the key-parameters in anisotropic plasma etching. Since direct ion energy distribution (IED) measurements at the treated surface during plasma processing are often hardly possible, there is an opportunity for virtual ones. This work is devoted to the possibility of such indirect IED and ion flux measurements at an rf-biased electrode in low-pressure rf plasma by using a “virtual IED sensor” which represents “in-situ” IED calculations on the absolute scale in accordance with a plasma sheath model containing a set of measurable external parameters. The “virtual IED sensor” should also involve some external calibration procedure. Applicability and accuracy of the “virtual IED sensor” are validated for a dual-frequency reactive ion etching (RIE) inductively coupled plasma (ICP) reactor with a capacitively coupled rf-biased electrode. The validation is carried out for heavy (Ar) and light (H{sub 2}) gases under different discharge conditions (different ICP powers, rf-bias frequencies, and voltages). An EQP mass-spectrometer and an rf-compensated Langmuir probe (LP) are used to characterize plasma, while an rf-compensated retarded field energy analyzer (RFEA) is applied to measure IED and ion flux at the rf-biased electrode. Besides, the pulsed selfbias method is used as an external calibration procedure for ion flux estimating at the rf-biased electrode. It is shown that pulsed selfbias method allows calibrating the IED absolute scale quite accurately. It is also shown that the “virtual IED sensor” based on the simplest collisionless sheath model allows reproducing well enough the experimental IEDs at the pressures when the sheath thickness s is less than the ion mean free path λ{sub i} (s < λ{sub i}). At higher pressure (when s > λ{sub i}), the difference between calculated and experimental IEDs due to ion collisions in the sheath is observed in the low

  2. IEEE standard for qualifying class IE equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1974-01-01

    The Institute of Electrical and Electrical Engineers, Inc. (IEEE) standards for electrical equipment (Class IE) for nuclear power generating stations are given. The standards are to provide guidance for demonstrating and documenting the adequacy of electric equipment used in all Class IE and interface systems. Representative in containment design basis event conditions for the principal reactor types are included in the appendixes for guidance in enviromental simulation

  3. Soil Protection in the EU According to the Directive on Industrial Emissions (IED and Croatian Practice

    Directory of Open Access Journals (Sweden)

    Ivan Pilaš

    2014-06-01

    Full Text Available Background and Purpose: Soil protection against pollution in EU is mostly covered in a new Directive on industrial emissions (IED, adopted on November 24, 2010 as a follow up of the IPPC Directive. For all industrial facilities that fall under IED, the Directive obliges the establishment of a complex system of management of contaminated soil at the national level, in order to facilitate the implementation of the principle of “polluter pays” furthermore to reduce the risk of contamination of soil and groundwater. Material and Methods: This paper presents an overview of soil management system that should be established in each EU country to fulfil IED requirements. It consists of a meta-analysis of IED requirements and current state and drawbacks of soil protection in Croatia including present state of legislation, responsibility of authorities, soil surveys and remediation activities. Results and Conclusions: IED set the obligation on the industrial operator before the start of production to prepare a report on the initial state of soil as a necessary requirement for obtaining environmental permit. It set obligations for monitoring of soil and groundwater status in the location of industrial facility for a period of ten (soil and five years (groundwater. After the cessation of production, and in the case of exceeding critical limits of pollution, the operator is obliged to perform remediation or restitution of land in the state as it was at the beginning of production. Management of contaminated soil according to IED requirements obliges the Croatian government to establish a complex multi-level system. At first it requires better definition of responsibilities between two ministries; Ministry of Environmental and Nature protection and Ministry of Agriculture. IED requires enactment of adequate legal basis (i.e. Soil protection act and the establishment of operational instruments for the implementation of soil protection, such as a register

  4. Seismic and environmental qualification of class IE equipment manufactured in Spain

    International Nuclear Information System (INIS)

    Gerini, P.; Lumbreras, A.; Naredo, F.

    1978-01-01

    Nuclear power plant instrumentation and control design is affected by several factors such as various plant operating conditions, transient response capability, safety requirements and changes in IEEE standards. Recent upgraded IEEE standards that call for Qualification of all Safety related I anc C equipment, namely IEEE 323 (Qualifying Class IE Electric Equipment for nuclear power generating stations) and its daughter Standard IEEE 344 (Recommended Practices for Seismic Qualification of Class IE Equipment for nuclear power generating stations) have been endorsed by the United States Nuclear Regulatory Commission through the issuance of corresponding Regulatory Guides. The author describes the Qualification requirements applicable to the Class IE I and C Components made in Spain for the different vintages of plants, and the programs implemented or plans established by Westinghouse to fulfill those requirements. (author)

  5. Biotransformation of isoeugenol to vanillin by Pseudomonas putida IE27 cells.

    Science.gov (United States)

    Yamada, Mamoru; Okada, Yukiyoshi; Yoshida, Toyokazu; Nagasawa, Toru

    2007-01-01

    The ability to produce vanillin and/or vanillic acid from isoeugenol was screened using resting cells of various bacteria. The vanillin- and/or vanillic-acid-producing activities were observed in strains belonging to the genera Achromobacter, Aeromonas, Agrobacerium, Alcaligenes, Arthrobacter, Bacillus, Micrococcus, Pseudomonas, Rhodobacter, and Rhodococcus. Strain IE27, a soil isolate showing the highest vanillin-producing activity, was identified as Pseudomonas putida. We optimized the culture and reaction conditions for vanillin production from isoeugenol using P. putida IE27 cells. The vanillin-producing activity was induced by adding isoeugenol to the culture medium but not vanillin or eugenol. Under the optimized reaction conditions, P. putida IE27 cells produced 16.1 g/l vanillin from 150 mM isoeugenol, with a molar conversion yield of 71% at 20 degrees C after a 24-h incubation in the presence of 10% (v/v) dimethyl sulfoxide.

  6. La IED en galicia. situación actual y estrategias de futuro

    Directory of Open Access Journals (Sweden)

    Ramos Calvo, Agustín

    2006-01-01

    Full Text Available En este trabajo se trata de apuntar algunos de los posibles factores que pueden estar detrás de la escasa capacidad mostrada por la economía gallega para atraer a la inversión extranjera Directa (IED que se dirigió a España a lo largo del periodo 1993-2002; sugiriendo, además, una serie de medidas para contribuir a corregir ese problema, y reducir las posibles deslocalizaciones empresariales. Para ello se comparan las estructuras productivas y de la IED de España y Galicia, así como la diferencia entre la productividad parcial por trabajador y el coste por trabajador entre todas las CC.AA. españolas; ya que ésta es una de las principales variables que explica la distribución sectorial y regional de la IED en España en el periodo considerado.

  7. ANSI/ASHRAE/IES Standard 90.1-2013 Determination of Energy Savings: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Hart, Philip R.; Richman, Eric E.; Athalye, Rahul A.; Winiarski, David W.

    2014-09-04

    This report provides a final qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition). All addenda in creating Standard 90.1-2013 were evaluated for their projected impact on energy efficiency. Each addendum was characterized as having a positive, neutral, or negative impact on overall building energy efficiency.

  8. A summary of the performance of exposure rate and dose rate instruments contained in instrument evaluation reports NRPB-IE1 to NRPB-IE13

    International Nuclear Information System (INIS)

    Burgess, P.H.; Iles, W.J.

    1979-06-01

    of the instrument evaluation programme and published in the NRPB-IE report series

  9. An Active Type I-E CRISPR-Cas System Identified in Streptomyces avermitilis.

    Directory of Open Access Journals (Sweden)

    Yi Qiu

    Full Text Available CRISPR-Cas systems, the small RNA-dependent immune systems, are widely distributed in prokaryotes. However, only a small proportion of CRISPR-Cas systems have been identified to be active in bacteria. In this work, a naturally active type I-E CRISPR-Cas system was found in Streptomyces avermitilis. The system shares many common genetic features with the type I-E system of Escherichia coli, and meanwhile shows unique characteristics. It not only degrades plasmid DNA with target protospacers, but also acquires new spacers from the target plasmid DNA. The naive features of spacer acquisition in the type I-E system of S. avermitilis were investigated and a completely conserved PAM 5'-AAG-3' was identified. Spacer acquisition displayed differential strand bias upstream and downstream of the priming spacer, and irregular integrations of new spacers were observed. In addition, introduction of this system into host conferred phage resistance to some extent. This study will give new insights into adaptation mechanism of the type I-E systems in vivo, and meanwhile provide theoretical foundation for applying this system on the genetic modification of S. avermitilis.

  10. Discourse Surrounding the International Education Standards for Professional Accountants (IES): A Content Analysis Approach

    Science.gov (United States)

    Sugahara, Satoshi; Wilson, Rachel

    2013-01-01

    The development and implementation of the International Education Standards (IES) for professional accountants is currently an important issue in accounting education and for educators interested in a shift toward international education standards more broadly. The purpose of this study is to investigate professional and research discourse…

  11. Stage IE nonHodgkin's lymphoma of the testis: a need for a brief aggressive chemotherapy

    International Nuclear Information System (INIS)

    Roche, H.; Suc, E.; Pons, A.; Woodman, F.; Huguet-Rigal, F.; Caveriviere, P.; Carton, M.

    1989-01-01

    Primary nonHodgkin's lymphoma of the testis is a localized disease in 50 per cent of the cases. Clinical records and pathological material from 9 stage IE cancer patients treated at our institutions were reviewed. All but 1 patient had B cell type lymphomas of intermediate (6) or high (3) grade according to the Working Formulation. Mean survival was 49 months and actuarial survival was 74 per cent at 5 years. Chemotherapy differed with time and frequently was associated with subdiaphragmatic involved field and prophylactic contralateral testis radiotherapy. In view of the good prognosis of patients receiving doxorubicin-based chemotherapy and recent reports on low stage nonHodgkin's lymphoma we recommend an aggressive brief therapy for stage IE lymphoma of the testis after orchiectomy

  12. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Hart, Reid; Athalye, Rahul A.; Rosenberg, Michael I.; Richman, Eric E.; Winiarski, David W.

    2014-03-01

    Section 304(b) of the Energy Conservation and Production Act (ECPA), as amended, requires the Secretary of Energy to make a determination each time a revised version of ASHRAE Standard 90.1 is published with respect to whether the revised standard would improve energy efficiency in commercial buildings. When the U.S. Department of Energy (DOE) issues an affirmative determination on Standard 90.1, states are statutorily required to certify within two years that they have reviewed and updated the commercial provisions of their building energy code, with respect to energy efficiency, to meet or exceed the revised standard. This report provides a preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition).

  13. Product analysis illuminates the final steps of IES deletion in Tetrahymena thermophila.

    Science.gov (United States)

    Saveliev, S V; Cox, M M

    2001-06-15

    DNA sequences (IES elements) eliminated from the developing macronucleus in the ciliate Tetrahymena thermophila are released as linear fragments, which have now been detected and isolated. A PCR-mediated examination of fragment end structures reveals three types of strand scission events, reflecting three steps in the deletion process. New evidence is provided for two steps proposed previously: an initiating double-stranded cleavage, and strand transfer to create a branched deletion intermediate. The fragment ends provide evidence for a previously uncharacterized third step: the branched DNA strand is cleaved at one of several defined sites located within 15-16 nucleotides of the IES boundary, liberating the deleted DNA in a linear form.

  14. A methodology aimed at fostering and sustaining the development processes of an IE-based industry

    Science.gov (United States)

    Corallo, Angelo; Errico, Fabrizio; de Maggio, Marco; Giangreco, Enza

    In the current competitive scenario, where business relationships are fundamental in building successful business models and inter/intra organizational business processes are progressively digitalized, an end-to-end methodology is required that is capable of guiding business networks through the Internetworked Enterprise (IE) paradigm: a new and innovative organizational model able to leverage Internet technologies to perform real-time coordination of intra and inter-firm activities, to create value by offering innovative and personalized products/services and reduce transaction costs. This chapter presents the TEKNE project Methodology of change that guides business networks, by means of a modular and flexible approach, towards the IE techno-organizational paradigm, taking into account the competitive environment of the network and how this environment influences its strategic, organizational and technological levels. Contingency, the business model, enterprise architecture and performance metrics are the key concepts that form the cornerstone of this methodological framework.

  15. The application of NISA II FEM package in seismic qualification of small class IE electric motors

    International Nuclear Information System (INIS)

    Fancev, T.; Saban, I.; Grgic, D.

    1995-01-01

    According to the IEEE standards 323/1974 and 344/1975, seismic qualification of class IE equipment is appropriate combination of test and analysis methods. Complex equipment and assemblies are usually tested through seismic testing. The analysis is recommended for simple equipment that can be easily modeled to correctly predict its response. This article deals with the application of NISA II FEM package in 3D FE modeling and mode shape calculations of small power low voltage electric motors. (author)

  16. Medicine against Cold War. Physicians in the anti-nuclear peace movement of the 1980ies

    International Nuclear Information System (INIS)

    Kemper, Claudia

    2016-01-01

    The book on physicians in the anti-nuclear peace movement of the 19080ies covers the following issues: (I) Frame of the subject: methodology, research fields and actors; (II) The social dimension of the physician's movement; (III) IPPNW (International physicians for the prevention of nuclear war) - a political idea is medicalized and organized, 1980 - 1984; (IV) Borderlines of the international peace idea during the Cold War - IPPNW 1980 - 1986.

  17. Assessment of current NRC/IE professional training program and recommendations for improvement

    International Nuclear Information System (INIS)

    Bartley, H.J.; Hagerup, J.E.; Harrison, O.J.; Heyer, F.H.K.; Kaas, I.W.; Schwartz, E.G.

    1978-05-01

    This document is the General Research Corporation (GRC) report on Task III: to assess the current NRC/IE professional training program and to provide recommendations for improvement. The major objectives of this task were to determine the overall effectiveness of the NRC/IE training program and to provide recommendations for improvements where appropriate. The research involved a review of course manuals and of student critiques, observation in the classroom and person to person interviews; it also included an evaluation of the assignment of instructors to the Career Management Branch. Findings addressed refresher training, retread training and initial training--with emphasis on the last of these. Conclusions are that: (1) The curriculum provides, in general, types and levels of training needed; (2) the mix of training methods used is correct; and (3) the training management is effective. However, the training facilities do not reflect a commitment to quality instruction nor is assignment as instructor to the Career Management Branch attractive to inspectors. Recommendations presented in the report are based upon the findings; all lie within the implementing authority of Headquarters NRC/IE

  18. Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence

    Directory of Open Access Journals (Sweden)

    Khodamorad Jamshidi

    2015-01-01

    Full Text Available Background:   Primary bone lymphoma or non-Hodgkin lymphoma of bone is a rare disease. There are only a few case series of stage IE of this condition in medical literature. The aim of this study is to determine the rate of survival   for stage IE after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     Methods:   We collected data from 61 patients with histologically confirmed PBL treated at the Musculoskeletal   Oncology Department of our hospital from 2000 to 2010. Retrospective evaluation included demographics, symptoms, tumor locations, outcomes of surgical treatment for local recurrence and survival rates. Results:   All patients received Combined Modality Therapy. Overall,five year survival was 89% and five year disease free survival rate was 78%. Local recurrence occurred in 6 patients during follow up period, which was treated surgically     by wide excision and reconstruction. The mean follow-up for the local recurrence group was 36(24-54 months and mortality rate in this group was 17%. Conclusions:   Combined Modality Therapy for stage IE primary bone lymphomaresults in good survival rate. In case   of local recurrence, wide excision and reconstruction improves the outcomes.

  19. Noise and Vibration Monitoring for Premium Efficiency IE 3 Three-Phase Induction Motors

    Directory of Open Access Journals (Sweden)

    NISTOR, C. G.

    2015-08-01

    Full Text Available The paper presents the original SV-100 platform that enables low-cost and very high accuracy determinations of noise and vibration levels. The aim of the proposed platform is to achieve an effective integration of the two topics of this analysis: vibrations and noises. To the best of our knowledge, no low price, dedicated compact platform with embedded measuring instruments exists. For proving the practical utility of the proposed platform, two induction motors of 7.5 kW and 11 kW, respectively, in single-layer winding, at 1000 rpm, with IE3 premium efficiency were analyzed. This analysis is required because, according to IEC60034-30 standard, the IE3 efficiency standard has become mandatory for induction motors of rated power greater than 7.5 kW. Therefore, in order to improve the motor operating efficiency, the power losses caused by noises and vibrations have to be reduced. Several variants of supply were studied, i.e., by the three-phase 50 Hz network and by a three-phase inverter at 40, 50 and 60 Hz, respectively. The experimental determinations of noises are presented comparatively, by using a Bruel&Kjaer sonometer and by using the new platform SV-100. The results are compared with the IEC60034 standard.

  20. Recommendations on nuclear and multimodality imaging in IE and CIED infections.

    Science.gov (United States)

    Erba, Paola Anna; Lancellotti, Patrizio; Vilacosta, Isidre; Gaemperli, Oliver; Rouzet, Francois; Hacker, Marcus; Signore, Alberto; Slart, Riemer H J A; Habib, Gilbert

    2018-05-24

    In the latest update of the European Society of Cardiology (ESC) guidelines for the management of infective endocarditis (IE), imaging is positioned at the centre of the diagnostic work-up so that an early and accurate diagnosis can be reached. Besides echocardiography, contrast-enhanced CT (ce-CT), radiolabelled leucocyte (white blood cell, WBC) SPECT/CT and [ 18 F]FDG PET/CT are included as diagnostic tools in the diagnostic flow chart for IE. Following the clinical guidelines that provided a straightforward message on the role of multimodality imaging, we believe that it is highly relevant to produce specific recommendations on nuclear multimodality imaging in IE and cardiac implantable electronic device infections. In these procedural recommendations we therefore describe in detail the technical and practical aspects of WBC SPECT/CT and [ 18 F]FDG PET/CT, including ce-CT acquisition protocols. We also discuss the advantages and limitations of each procedure, specific pitfalls when interpreting images, and the most important results from the literature, and also provide recommendations on the appropriate use of multimodality imaging.

  1. Smokeless Propellants as Vehicle Borne IED Main Charges: An Initial Threat Assessment

    Science.gov (United States)

    2008-01-01

    explosives license or permit must submit a photograph and fingerprints to the ATF and undergo a background investigation. The law prohibits certain persons...container with four M 16 screws. A piece of canvas * is placed and pinched between the F of the containe~and the grate. The grate mesh measures 30 X 30 rom...lb) above, but instead of a grate and canvas , two boards of pine wood, each 12 mm thick being stacked on top of one another. as per (Ie) above, but

  2. Lessons learned in the environmental qualification of class IE equipment at Tennessee Valley Authority

    International Nuclear Information System (INIS)

    Bell, R.N.; Akos, T.

    1985-01-01

    Tennessee Valley Authority has been engaged in an extensive program for the environmental qualification of Class 1E components. This program has been conducted in accordance with the requirements set forth in various industry standards and federal regulations, including IEEE 323-1971, IEEE 323-1974, Nuclear Regulatory Commission (NRC) IE Bulletin 7901B, NRC NUREG-0588, and the Code of Federal Regulations 10CFR50.49. Valuable lessons have been learned as a result of this program, particularly in the area of environmental qualification testing. This paper describes some unique experiences in the qualification testing of main steam isolation valve control manifold assemblies, control relays, and motor control centers

  3. CONSIDERAŢII PRIVIND IMPORTANŢA METODEI DE CALCULAŢIE A COSTULUI PE COMENZI

    Directory of Open Access Journals (Sweden)

    Svetlana MIHAILA

    2016-12-01

    Full Text Available În acest articol este prezentată o modalitate de organizare a contabilităţii de gestiune şi a calculaţiei costurilor prin metoda pe comenzi. Sunt tratate etapele de derulare a metodei de calculaţie a costului pe comenzi, respectiv rolul conta­bilului de gestiune în derularea şi implementarea acestei metode. Din punct de vedere teoretic şi aplicativ, sunt abordate etapele metodologice parcurse în contabilitatea de gestiune şi calculaţia costurilor.Concluziile formulate vizează organizarea contabilităţii de gestiune; entitatea trebuie să aplice cea mai eficientă metodă de calculaţie, ba chiar şi o combinaţie de metode de calculaţie – clasice şi moderne, în concordanţă cu parti­cularităţile tehnologiei şi organizării producţiei, precum şi cu cerinţele unei administrări eficiente. Totodată, sunt abor­date şi avantajele pe care le oferă metoda pe comenzi, de unde derivă şi importanţa acestui subiect. CONSIDERATIONS ON THE IMPORTANCE OF THE JOB-ORDER COSTING SYSTEM The authors present a method for the organization of the management accounting and job-order costing. Consideration has been given to the stages of the job-order costing system, as well as to the role of the accountant in the application and implementation of such method. The authors have adopted a theoretical and applicative approach in regard to the methodological stages covered by the management accounting and the costing method.The article ends with the authors' conclusions regarding the organization of the management accounting. In this respect, it outcomes that an entity is to apply the most efficient costing method and, moreover, a combination of classical and modern costing methods, in accordance with the specific features of the manufacturing process and production engineering, as well as the efficient management requirements. The authors have also shed light on the advantages offered by the job-order costing system, and the resulting

  4. Evaluation of ANSI/ASHRAE/USGBC/IES Standard 189.1-2009

    Energy Technology Data Exchange (ETDEWEB)

    Long, N.; Bonnema, E.; Field, K.; Torcellini, P.

    2010-07-01

    The National Renewable Energy Laboratory (NREL) evaluated ANSI/ASHRAE/USGBC/IES Standard 189.1-2009, 'The Standard for High-Performance Green Buildings Except Low-Rise Residential Buildings'. NREL performed this evaluation by examining the results of predictions for site energy use from a comprehensive set of EnergyPlus models. NREL has conducted an 'order-of-magnitude' analysis in this study to identify the likely overall impact of adopting Standard 189.1-2009 over ANSI/ASHRAE/IESNA Standard 90.1-2007.

  5. OPTIMIZAREA DETERMINĂRII CAPACITĂŢII DE INHIBIŢIE A APELOR NATURALE

    Directory of Open Access Journals (Sweden)

    Vladislav BLONSCHI

    2018-03-01

    Full Text Available În lucrare sunt prezentate rezultatele studiului multianual ce ţin de optimizarea determinării capacităţii de inhibiţie, obţinute în urma prelucrării statistice a datelor empirice din perioada anilor 2008-2017. În rezultatul prelucrării statistice a datelor multianuale, a fost propusă valoarea medie a vitezei de decolorare a indicatorului PNDMA în apă distilată, care optimizează calcularea capacităţii de inhibiţie a apelor. OPTIMIZE DETERMINATION OF NATURAL WATER INHIBITION CAPACITYThis paper contain the results of multi-annual study on the optimization of inhibition capacity determination, obtained after statistical processing of empirical data from 2008-2017. Thereafter of statistical processing of multi-annual data, it was proposed the average value of fading speed of PNDMA indicator in distilled water, that optimize computation of the inhibition capacity of waters. 

  6. Reliability and validity of the Impact of Event Scale (IES): version for Brazilian burn victims.

    Science.gov (United States)

    Echevarria-Guanilo, Maria E; Dantas, Rosana A S; Farina, Jayme A; Alonso, Jordi; Rajmil, Luis; Rossi, Lídia A

    2011-06-01

    The aims of this study were to assess the internal reliability (internal consistency), construct validity, sensitivity and ceiling and floor effects of the Brazilian-Portuguese version of the Impact of Event Scale (IES). Methodological research design. The Brazilian-Portuguese version of the IES was applied to a group of 91 burned patients at three times: the first week after the burn injury (time one), between the fourth and the sixth months (time two) and between the ninth and the 12th months (time three). The internal consistency, construct validity (convergent and dimensionality), sensitivity and ceiling and floor effects were tested. Cronbach's alpha coefficients showed high internal consistency for the total scale (0·87) and for the domains intrusive thoughts (0·87) and avoidance responses (0·76). During the hospitalisation (time one), the scale showed low and positive correlations with pain measures immediately before (r=0·22; pnegative correlations with self-esteem (r=-0·52; plow and negative with the Bodily pain (r=-0·24; pimpact of the event in the group of patients under analysis. The Impact of Event Scale can be used in research and clinical practice to assess nursing interventions aimed at decreasing stress during rehabilitation. © 2011 Blackwell Publishing Ltd.

  7. The Plant Genome Integrative Explorer Resource: PlantGenIE.org.

    Science.gov (United States)

    Sundell, David; Mannapperuma, Chanaka; Netotea, Sergiu; Delhomme, Nicolas; Lin, Yao-Cheng; Sjödin, Andreas; Van de Peer, Yves; Jansson, Stefan; Hvidsten, Torgeir R; Street, Nathaniel R

    2015-12-01

    Accessing and exploring large-scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. We present the integrated PlantGenIE.org platform for exploration of Populus, conifer and Arabidopsis genomics data, which includes expression networks and associated visualization tools. Standard features of a model organism database are provided, including genome browsers, gene list annotation, Blast homology searches and gene information pages. Community annotation updating is supported via integration of WebApollo. We have produced an RNA-sequencing (RNA-Seq) expression atlas for Populus tremula and have integrated these data within the expression tools. An updated version of the ComPlEx resource for performing comparative plant expression analyses of gene coexpression network conservation between species has also been integrated. The PlantGenIE.org platform provides intuitive access to large-scale and genome-wide genomics data from model forest tree species, facilitating both community contributions to annotation improvement and tools supporting use of the included data resources to inform biological insight. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

  8. ABORDAREA PSIHOLINGVISTICĂ ŞI SOCIOLINGVISTICĂ A CONCEPTULUI EMOŢIE

    Directory of Open Access Journals (Sweden)

    Viorica LIFARI

    2015-12-01

    Full Text Available În ultimul timp categoria conceptuală a emoţiilor este cercetată în contextul studiilor interdisciplinare şi al celor interculturale. Atât în domeniul psihologiei, cât şi în cel al lingvisticii savanţii se împart în mai multe şcoli, bunăoară: reprezentanţii teoriei despre universalitatea emoţiilor şi cei care accentuează impactul sociocultural al dezvoltării şi cul­ti­vării categoriilor conceptuale ale emoţiilor în cadrul unei etnii sau culturi.În articolul de faţă autorul pune în discuţie opiniile savanţilor antropologi şi lingvişti cu privire la modelarea concep­tului de emoţie în cadrul unei culturi şi posibilitatea de a analiza acest concept prin prisma ambelor teorii: atât a celei de universalitate a conceptului de emoţie, cât şi a teoriei despre individualitatea acestuia. THE PSYCHO-LINGUISTIC AND SOCIO-LINGUISTIC APPROACH TO THE CONCEPT OF EMOTION The conceptual category of emotions has recently more often been studied on the cross-cultural level. This type of research has been done among both psychologists and linguists who are further representing different schools or ideas, as for example the adherents of the theory of universal emotions and those that emphasize the socio-cultural impact of the development of the concept of emotion within a certain ethnic community or culture.The article under discussion offers the reader the ideas and points of view of researchers in the field of psychology, anthropology and linguistics concerning the concept of emotions within a certain culture and the possibility to analyse the given concept through the prism of both theories: that of the universality of emotions on the one hand and that of the cultural specificity of emotion on the other one.

  9. Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system.

    Science.gov (United States)

    Kiro, Ruth; Shitrit, Dror; Qimron, Udi

    2014-01-01

    The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) system has recently been used to engineer genomes of various organisms, but surprisingly, not those of bacteriophages (phages). Here we present a method to genetically engineer the Escherichia coli phage T7 using the type I-E CRISPR-Cas system. T7 phage genome is edited by homologous recombination with a DNA sequence flanked by sequences homologous to the desired location. Non-edited genomes are targeted by the CRISPR-Cas system, thus enabling isolation of the desired recombinant phages. This method broadens CRISPR Cas-based editing to phages and uses a CRISPR-Cas type other than type II. The method may be adjusted to genetically engineer any bacteriophage genome.

  10. Las teorias de la localizacion de la inversion extranjera directa (IED: una aproximacion.

    Directory of Open Access Journals (Sweden)

    Villarreal, C.

    2004-07-01

    Full Text Available El objetivo de esta obra es presentar una aproximación al estado actual del arte en el tema. En este sentido, se intentarán exponer los motivos que desencadenan que las diversas teorías relativas a la Inversión Extranjera Directa (IED no proporcionen una respuesta unánime sobre la localización del capital extranjero con fines productivos, enfatizando la ausencia de modelos cuantitativos para explicar los factores en la decisión de invertir en el extranjero. Se presentan los conceptos y definiciones fundamentales relacionados con el tema. Finalmente, ofrece una perspectiva sobre el quehacer en las investigaciones relacionadas al tema.

  11. ANSI/ASHRAE/IES Standard 90.1-2013 Determination of Energy Savings: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Athalye, Rahul A.; Rosenberg, Michael I.; Xie, YuLong; Wang, Weimin; Hart, Philip R.; Zhang, Jian; Goel, Supriya; Mendon, Vrushali V.

    2014-09-04

    This report provides a final quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in improved energy efficiency in commercial buildings. The final analysis considered each of the 110 addenda to Standard 90.1-2010 that were included in Standard 90.1-2013. PNNL reviewed all addenda included by ASHRAE in creating Standard 90.1-2013 from Standard 90.1-2010, and considered their combined impact on a suite of prototype building models across all U.S. climate zones. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE’s final determination. However, out of the 110 total addenda, 30 were identified as having a measureable and quantifiable impact.

  12. ANSI/ASHRAE/IES Standard 90.1-2016 Performance Rating Method Reference Manual

    Energy Technology Data Exchange (ETDEWEB)

    Goel, Supriya [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Eley, Charles [Eley and Associates, Hobe Sound, FL (United States)

    2017-09-29

    This document is intended to be a reference manual for the Appendix G Performance Rating Method (PRM) of ANSI/ASHRAE/IES Standard 90.1-2016 (Standard 90.1-2016). The PRM can be used to demonstrate compliance with the standard and to rate the energy efficiency of commercial and high-rise residential buildings with designs that exceed the requirements of Standard 90.1. Use of the PRM for demonstrating compliance with Standard 90.1 is a new feature of the 2016 edition. The procedures and processes described in this manual are designed to provide consistency and accuracy by filling in gaps and providing additional details needed by users of the PRM.

  13. The Slavery in Circassia and the United States (1850–1860-ies years: General and Special

    Directory of Open Access Journals (Sweden)

    Mikhal Smigel

    2016-12-01

    Full Text Available The article provides a comparative analysis of slavery in Circassia and in the territory of the slave South in the United States in 1850–1860-ies years in the context of the fight against the slave trade and slavery in the world. The article discusses the Russian-American general trends for the prohibition of slavery and the slave trade. Among the materials are Russian and foreign archival sources, documents of personal origin (memoirs, diaries of travelers as well as scientific research. The methodological basis of historical-comparative study are the principles of objectivity and historicism, suggesting an unbiased approach to the analysis of the studied problems, a critical attitude to the sources, making judgments as a result of the analysis of a set of facts, and displays the slave of phenomena in the development and the context of the historical situation. In conclusion, the authors note that slavery and the slave position in the United States and the Circassia had their differences in 1850–1860-ies. Such differences included the inability of the transition to the United States from the status of a slave in the state of the dependent peasant, which was the norm in Circassia. In the United States the slaves were brought from outside, while in Circassia the slavery occurred in the region, mainly by trapping. At the root of discrimination in the United States was the racial principle, in Circassia this is based on the religious principle. The position of slaves had their similarities. A slave was powerless property of his master, there were certain unwritten rules governing the relationship, slave owners were reluctant to bring slaves to the extreme and etc. The important similarity between the US and Circassia was the presence of their territories with a strong slave system, where slaves constituted more than 30 % of the population. In the US, it was the territory of the slave-holding South, and in Circassia – the slaveholding Ubykhia.

  14. Irradiation Effects Test Series: Test IE-3. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, L. C.; Allison, C. M.; Croucher, D. W.; Ploger, S. A.

    1977-10-01

    The objectives of the test reported were to: (a) determine the behavior of irradiated fuel rods subjected to a rapid power increase during which the possibility of a pellet-cladding mechanical interaction failure is enhanced and (b) determine the behavior of these fuel rods during film boiling following this rapid power increase. Test IE-3 used four 0.97-m long pressurized water reactor type fuel rods fabricated from previously irradiated fuel. The fuel rods were subjected to a preconditioning period, followed by a power ramp to 69 kW/m at a coolant mass flux of 4920 kg/s-m/sup 2/. After a flow reduction to 2120 kg/s-m/sup 2/, film boiling occurred on the fuel rods. One rod failed approximately 45 seconds after the reactor was shut down as a result of cladding embrittlement due to extensive cladding oxidation. Data are presented on the behavior of these irradiated fuel rods during steady-state operation, the power ramp, and film boiling operation. The effects of a power ramp and power ramp rates on pellet-cladding interaction are discussed. Test data are compared with FRAP-T3 computer model calculations and data from a previous Irradiation Effects test in which four irradiated fuel rods of a similar design were tested. Test IE-3 results indicate that the irradiated state of the fuel rods did not significantly affect fuel rod behavior during normal, abnormal (power ramp of 20 kW/m per minute), and accident (film boiling) conditions.

  15. IE Information Notice No. 85-82: Diesel generator differential protection relay not seismically qualified

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    Licensees of BWR and PWR nuclear generating stations have reported using a high-speed differential protection relay that has been declared by the manufacturer to be not seismically qualified for the service intended. The relay, GE Model 12CFD, which is being used for emergency diesel generator protection against electrical shorts and grounds at the generator output, has not been seismically qualified to operate in the de-energized state for this application. Generally, the relay operates in the de-energized position before EDG operation. However, it then operates in the energized position whenever the EDG provides an electrical output to essential Class IE components. The safety concern of this issue involves an inadvertent activation of the normally de-energized relay from a seismic event. Momentary activation of the relay, in the circuits examined, blocks the automatic start feature of the EDG during certain emergency plant conditions through operation of another relay in the system. The NRC review of the problems concluded that the relays should be seismically qualified in their energized and de-energized states to preclude their spurious activation during a seismic event. Additionally, review of GE's GER 3069 report, ''Relay Protection of Class IE Systems,'' shows that the 12CFD differential relays were successfully tested for 3.5 g in the energized modes and only 0.75 g in the de-energized mode. Review of GE's GER 3069 report also revealed that GE type IJD differential relays do meet seismic requirements in all modes of operation mentioned above and is the GE recommendation for replacement of the differential relay in question

  16. ANSI/ASHRAE/IES Standard 90.1-2010 Performance Rating Method Reference Manual

    Energy Technology Data Exchange (ETDEWEB)

    Goel, Supriya [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-05-01

    This document is intended to be a reference manual for the Appendix G Performance Rating Method (PRM) of ANSI/ASHRAE/IES Standard 90.1- 2010 (Standard 90.1-2010).The PRM is used for rating the energy efficiency of commercial and high-rise residential buildings with designs that exceed the requirements of Standard 90.1. The procedures and processes described in this manual are designed to provide consistency and accuracy by filling in gaps and providing additional details needed by users of the PRM. It should be noted that this document is created independently from ASHRAE and SSPC 90.1 and is not sanctioned nor approved by either of those entities . Potential users of this manual include energy modelers, software developers and implementers of “beyond code” energy programs. Energy modelers using ASHRAE Standard 90.1-2010 for beyond code programs can use this document as a reference manual for interpreting requirements of the Performance Rating method. Software developers, developing tools for automated creation of the baseline model can use this reference manual as a guideline for developing the rules for the baseline model.

  17. Irradiation effects test series, test IE-5. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Croucher, D. W.; Yackle, T. R.; Allison, C. M.; Ploger, S. A.

    1978-01-01

    Test IE-5, conducted in the Power Burst Facility at the Idaho National Engineering Laboratory, employed three 0.97-m long pressurized water reactor type fuel rods, fabricated from previously irradiated zircaloy-4 cladding and one similar rod fabricated from unirradiated cladding. The objectives of the test were to evaluate the influence of simulated fission products, cladding irradiation damage, and fuel rod internal pressure on pellet-cladding interaction during a power ramp and on fuel rod behavior during film boiling operation. The four rods were subjected to a preconditioning period, a power ramp to an average fuel rod peak power of 65 kW/m, and steady state operation for one hour at a coolant mass flux of 4880 kg/s-m/sup 2/ for each rod. After a flow reduction to 1800 kg/s-m/sup 2/, film boiling occurred on one rod. Additional flow reductions to 970 kg/s-m/sup 2/ produced film boiling on the three remaining fuel rods. Maximum time in film boiling was 80s. The rod having the highest initial internal pressure (8.3 MPa) failed 10s after the onset of film boiling. A second rod failed about 90s after reactor shutdown. The report contains a description of the experiment, the test conduct, test results, and results from the preliminary postirradiation examination. Calculations using a transient fuel rod behavior code are compared with the test results.

  18. Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

    Energy Technology Data Exchange (ETDEWEB)

    Tsige-Tamirat, H.; Ammirabile, L.; D' Agata, E.; Fuetterer, M.; Ranguelova, V. [European Commission, Joint Research Centre, Institute for Energy, Westerduinweg 3, 1755LE Petten (Netherlands)

    2010-07-01

    The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

  19. Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

    International Nuclear Information System (INIS)

    Tsige-Tamirat, H.; Ammirabile, L.; D'Agata, E.; Fuetterer, M.; Ranguelova, V.

    2010-01-01

    The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

  20. Removal of 137-Cs from Dissolved Hanford Tank Saltcake by Treatment with IE-911

    International Nuclear Information System (INIS)

    Rapko, Brian M.; Sinkov, Sergei I.; Levitskaia, Tatiana G.

    2003-01-01

    The U.S. Department of Energy's Richland Operations Office plans to accelerate the cleanup of the Hanford Site. Testing new technology for the accelerated cleanup will require dissolved saltcake from single-shell tanks. However, the 137Cs will need to be removed from the saltcake to alleviate radiation hazards. A saltcake composite constructed from archived samples from Hanford Site single-shell tanks 241-S-101, 241-S-109, 241-S-110, 241-S-111, 241-U-106, and 241-U-109 was dissolved in water, adjusted to 5 M Na, and transferred from the 222-S Laboratory to the Radiochemical Processing Laboratory (RPL). At the RPL, the approximately 5.5 liters of solution was passed through a 0.2-micron polyethersulfone filter, collected, and homogenized. The filtered solution then was passed through an ion exchange column containing approximately 150 mL IONSIV(reg s ign) IE-911, an engineered form of crystalline silicotitanate available from UOP, at approximately 200 mL/hour in a continuous operation until all of the feed solution had been run through the column. An analysis of the 137Cs concentrations in the initial feed solution and combined column effluent indicates that > 99.999 percent of the Cs in the feed solution was removed by this operation

  1. Outdoor γ-ray dose rate in Ajigasawa Town and environmental factors affecting it in IES

    International Nuclear Information System (INIS)

    Iyogi, Takashi; Hisamatsu, Shunichi; Sakurai, Naoyuki; Koyama, Kenji

    1999-01-01

    We surveyed the outdoor γ-ray dose rate throughout Aomori Prefecture from 1991 to 1995, and found an annual mean dose rate of 46 nGy h -1 . Relatively high dose rates were also observed in several areas (municipalities) of the survey locations. In this study, we examined the detailed distribution of the γ-ray dose rate in one such high dose rate area, Ajigasawa Town. Glass dosimeters were used for the monitoring of cumulative γ-ray dose rate at 10 locations in the town. The dose rate from each radioactive nuclide in the ground at the monitoring locations was measured by using an in situ γ-ray spectrometer with a Ge detector. The results obtained with the glass dosimeters showed that the γ-ray dose rates in Ajigasawa Town varied from 48 to 57 nGy h -1 . Although the dose rates were generally higher than the mean dose in Aomori Prefecture (1992-1995), the rates were lower than other high dose rate areas which had already been measured. The in situ γ-ray spectrometry revealed that these relatively high dose rates were mainly caused by 40 K and Th series radionuclides in the town. The effect of meteorological conditions on the γ-ray dose rate was studied at a monitoring station in IES. The dose rate was continuously recorded by a DBM NaI(Tl) scintillation detector system. The mean dose rate obtained when precipitation was sensed was 27 nGy h -1 and higher than when no precipitation was sensed (23 nGy h -1 ). (author)

  2. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States.

    Science.gov (United States)

    Halvorsen, Bente L; Carlsen, Monica H; Phillips, Katherine M; Bøhn, Siv K; Holte, Kari; Jacobs, David R; Blomhoff, Rune

    2006-07-01

    Supplements containing ascorbic acid, alpha-tocopherol, or beta-carotene do not protect against oxidative stress-related diseases in most randomized intervention trials. We suggest that other redox-active phytochemicals may be more effective and that a combination of different redox-active compounds (ie, antioxidants or reductants) may be needed for proper protection against oxidative damage. We aimed to generate a ranked food table with values for total content of redox-active compounds to test this alternative antioxidant hypothesis. An assay that measures the total concentration of redox-active compounds above a certain cutoff reduction potential was used to analyze 1113 food samples obtained from the US Department of Agriculture National Food and Nutrient Analysis Program. Large variations in the content of antioxidants were observed in different foods and food categories. The food groups spices and herbs, nuts and seeds, berries, and fruit and vegetables all contained foods with very high antioxidant contents. Most food categories also contained products almost devoid of antioxidants. Of the 50 food products highest in antioxidant concentrations, 13 were spices, 8 were in the fruit and vegetables category, 5 were berries, 5 were chocolate-based, 5 were breakfast cereals, and 4 were nuts or seeds. On the basis of typical serving sizes, blackberries, walnuts, strawberries, artichokes, cranberries, brewed coffee, raspberries, pecans, blueberries, ground cloves, grape juice, and unsweetened baking chocolate were at the top of the ranked list. This ranked antioxidant food table provides a useful tool for investigations into the possible health benefit of dietary antioxidants.

  3. JRC/IE support activities to PHARE nuclear safety programmes. Dissemination of PHARE project results

    International Nuclear Information System (INIS)

    Ranguelova, V.; Pla, P.; Rieg, C.; Bieth, M.

    2005-01-01

    Nuclear safety in Europe is one of European Union's primary concerns, therefore the European Union decided to take a prominent role to help the New Independent States and countries of Central and Eastern Europe to ensure the safety of their nuclear reactors. The European Union TACIS and PHARE programmes in nuclear safety have been undertaken since 1990. The European Commission's Directorate General External Relations (EC DG RELEX) and, Directorate General Europe Aid Co-operation Office (EC DG AIDCO), are responsible for programming and management of implementation of TACIS projects. Directorate General Enlargement (EC DG ELARG) is responsible for programming PHARE programmes, but implementation of most projects has been decentralised since 1999 budget year to the Beneficiary countries. DG ELARG acts as backstopping for the relevant EC Delegations. In these activities, the TSSTP Unit at the JRC/IE in Petten, The Netherlands, is a technical and scientific adviser of DG RELEX and DG AIDCO and provides support to DG ELARG for very specific technical issues. Several PHARE projects aiming at improving nuclear safety have been successfully implemented for a number of plants from Central and Eastern Europe. In some cases major safety issues have been addressed by means of multi-country projects and results have been disseminated to the rest of the nuclear community. Although a lot of information has been exchanged at a bilateral level, further effort is needed to collect the project results in a systematic way and make them available by means of the internet. At present the TSSTP Unit is implementing two projects for dissemination of PHARE project results. This activity will take a better advantage of today's communication technologies and ensure the management of the acquired knowledge through preservation and user-friendly access and retrieval of the project results. The paper provides an outline of the TSSTP Unit relevant knowledge preservation initiative, a description

  4. SU-G-IeP3-14: Updating Tools for Radiographic Technique Charts

    Energy Technology Data Exchange (ETDEWEB)

    Walz-Flannigan, A; Lucas, J; Buchanan, K; Schueler, B [Mayo Clinic, Rochester, MN (United States)

    2016-06-15

    Purpose: Manual technique selection in radiography is needed for imaging situations where there is difficulty in proper positioning for AEC, prosthesis, for non-bucky imaging, or for guiding image repeats. Basic information about how to provide consistent image signal and contrast for various kV and tissue thickness is needed to create manual technique charts, and relevant for physicists involved in technique chart optimization. Guidance on technique combinations and rules-of-thumb to provide consistent image signal still in use today are based on measurements with optical density of screen-film combinations and older generation x-ray systems. Tools such as a kV-scale chart can be useful to know how to modify mAs when kV is changed in order to maintain consistent image receptor signal level. We evaluate these tools for modern equipment for use in optimizing proper size scaled techniques. Methods: We used a water phantom to measure calibrated signal change for CR and DR (with grid) for various beam energies. Tube current values were calculated that would yield a consistent image signal response. Data was fit to provide sufficient granularity of detail to compose technique-scale chart. Tissue thickness approximated equivalence to 80% of water depth. Results: We created updated technique-scale charts, providing mAs and kV combinations to achieve consistent signal for CR and DR for various tissue equivalent thicknesses. We show how this information can be used to create properly scaled size-based manual technique charts. Conclusion: Relative scaling of mAs and kV for constant signal (i.e. the shape of the curve) appears substantially similar between film-screen and CR/DR. This supports the notion that image receptor related differences are minor factors for relative (not absolute) changes in mAs with varying kV. However, as demonstrated creation of these difficult to find detailed technique-scales are useful tools for manual chart optimization.

  5. KOMPONEN WEB DATA ANALYZER PADA IE STUDI KASUS: AKSES WEB TERFAVORIT LABORATORIUM IBS TEKNIK INFORMATIKA - ITS

    Directory of Open Access Journals (Sweden)

    Darlis Heru Murti

    2005-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Perkembangan dunia internet baik dari segi teknologi maupun jumlah pengguna yang mengakses kian lama semakin bertambah. Hal ini juga berdampak dengan munculnya berbagai situs internet yang menawarkan berbagai hal serta tujuan yang berbeda. Untuk mengakses situs-situs tersebut diperlukan suatu alat yang disebut browser. Salah satu browser yang paling terkenal dan banyak digunakan saat ini adalah Microsoft Internet Explorer (IE. Kalau diperhatikan sebenarnya browser Internet Explorer telah menyediakan fitur khusus bernama Favorites (dapat diakses melalui menu atau toolbar untuk mencatat dan mengorganisasi web-web yang menjadi favorit user. Tetapi fitur Favorites ini kurang fleksibel karena pemasukan data maupun pengorganisasiannya masih bersifat manual oleh user. Untuk itu perlu diimplementasikan perangkat lunak dengan fitur Favorites yang bersifat otomatis dan dinamis sehingga untuk periode waktu maupun lokasi akses workstation tertentu bisa memiliki informasi favorit website yang berbeda-beda. Sebagai solusi yang dapat digunakan adalah dengan memanfaatkan teknologi rekayasa perangkat lunak yaitu pembuatan komponen yang melekat pada browser Internet Explorer atau lebih dikenal dengan istilah plugin Internet

  6. Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication

    Energy Technology Data Exchange (ETDEWEB)

    Khalil, Mohamed I., E-mail: mkhalil2@stanford.edu [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States); Department of Molecular Biology, National Research Centre, El-Buhouth St., Cairo (Egypt); Che, Xibing; Sung, Phillip; Sommer, Marvin H. [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States); Hay, John [Department of Microbiology and Immunology, School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY (United States); Arvin, Ann M. [Departments of Pediatrics and Microbiology & Immunology, Stan ford University School of Medicine, Stanford, CA (United States)

    2016-05-15

    VZV IE62 is an essential, immediate-early, tegument protein and consists of five domains. We generated recombinant viruses carrying mutations in the first three IE62 domains and tested their influence on VZV replication kinetics. The mutations in domain I did not affect replication kinetics while domain II mutations, disrupting the DNA binding and dimerization domain (DBD), were lethal for VZV replication. Mutations in domain III of the nuclear localization signal (NLS) and the two phosphorylation sites S686A/S722A resulted in slower growth in early and late infection respectively and were associated with IE62 accumulation in the cytoplasm and nucleus respectively. This study mapped the functional domains of IE62 in context of viral infection, indicating that DNA binding and dimerization domain is essential for VZV replication. In addition, the correct localization of IE62, whether nuclear or cytoplasmic, at different points in the viral life cycle, is important for normal progression of VZV replication. - Highlights: • Mutation of IE62 domain I did not affect VZV replication in melanoma cells. • IE62 domain II and III are important for VZV replication in melanoma cells. • Mutations of IE62 domain II (DBD) were lethal for virus replication. • Mutations of IE62 NLS and phosphorylation sites inhibited VZV replication. • NLS and S686A/S722A mutations altered localization of IE62 during early and late infection.

  7. Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication

    International Nuclear Information System (INIS)

    Khalil, Mohamed I.; Che, Xibing; Sung, Phillip; Sommer, Marvin H.; Hay, John; Arvin, Ann M.

    2016-01-01

    VZV IE62 is an essential, immediate-early, tegument protein and consists of five domains. We generated recombinant viruses carrying mutations in the first three IE62 domains and tested their influence on VZV replication kinetics. The mutations in domain I did not affect replication kinetics while domain II mutations, disrupting the DNA binding and dimerization domain (DBD), were lethal for VZV replication. Mutations in domain III of the nuclear localization signal (NLS) and the two phosphorylation sites S686A/S722A resulted in slower growth in early and late infection respectively and were associated with IE62 accumulation in the cytoplasm and nucleus respectively. This study mapped the functional domains of IE62 in context of viral infection, indicating that DNA binding and dimerization domain is essential for VZV replication. In addition, the correct localization of IE62, whether nuclear or cytoplasmic, at different points in the viral life cycle, is important for normal progression of VZV replication. - Highlights: • Mutation of IE62 domain I did not affect VZV replication in melanoma cells. • IE62 domain II and III are important for VZV replication in melanoma cells. • Mutations of IE62 domain II (DBD) were lethal for virus replication. • Mutations of IE62 NLS and phosphorylation sites inhibited VZV replication. • NLS and S686A/S722A mutations altered localization of IE62 during early and late infection.

  8. Planejamento e gestão estratégica nas IES comunitárias

    Directory of Open Access Journals (Sweden)

    Gissele Prette Heil

    2017-06-01

    Full Text Available Diante da complexidade da Gestão Universitária no âmbito Estadual e Nacional, destaca-se a importância de um Planejamento Estratégico bem elaborado, exequível e cujo desdobramento em ações, permite aos gestores atuarem em consonância com as exigências que se apresentam cotidianamente. O artigo tem como objetivo geral analisar como ocorre o processo de gestão estratégica nas Instituições Comunitárias do Sistema ACAFE.  Os objetivos específicos foram divididos em quatro etapas, a primeira aborda a Estratégia, com o objetivo analisar o processo de estratégia organizacional, a segunda o Pensamento Estratégico com o intuito de  identificar se possui indicadores da existência de pensamento estratégico, junto aos gestores, a terceira etapa destacará o  Planejamento Estratégico,  identificando se há e como é elaborado e a quarta etapa, considerando as etapas anteriores abordamos as ações decorrentes da possível existência dos requisitos anteriores, bem como, se dá a formulação e implantação de ações e como são efetuados o monitoramento e o controle das estratégias. Entende-se que o tema abordado é de grande relevância, pois as Instituições Comunitárias de Ensino – ICES, possuem características genéricas e específicas o que acaba na maioria das vezes tornando o processo estratégico muito complexo, difícil e pouco efetivo. Cada vez mais as Instituições de Ensino Superior – IES, precisam formular suas estratégias adequando-as para atender as demandas latentes, desenvolvendo um processo de inteligência competitiva, permitindo lidar de modo mais eficaz com a concorrência, destacando o diferencial competitivo e atributos de valor percebidos pela comunidade onde está inserida. É de singular importância buscar a diferenciação, o destaque, a projeção necessária nos tempos atuais, para que possam sobreviver e crescer. Utilizou-se para a presente investigação o método de pesquisa explorat

  9. Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper Functioning.

    Science.gov (United States)

    Tung, Hsuan; Wei, Sung-Chan; Lo, Huei-Ru; Chao, Yu-Chan

    2016-01-01

    Baculoviruses have gained popularity as pest control agents and for protein production in insect systems. These viruses are also becoming popular for gene expression, tissue engineering and gene therapy in mammalian systems. Baculovirus infection triggers a heat shock response, and this response is crucial for its successful infection of host insect cells. However, the viral protein(s) or factor(s) that trigger this response are not yet clear. Previously, we revealed that IE2-an early gene product of the baculovirus-could form unique nuclear bodies for the strong trans-activation of various promoters in mammalian cells. Here, we purified IE2 nuclear bodies from Vero E6 cells and investigated the associated proteins by using mass spectrometry. Heat shock proteins (HSPs) were found to be one of the major IE2-associated proteins. Our experiments show that HSPs are greatly induced by IE2 and are crucial for the trans-activation function of IE2. Interestingly, blocking both heat shock protein expression and the proteasome pathway preserved the IE2 protein and its nuclear body structure, and revived its function. These observations reveal that HSPs do not function directly to assist the formation of the nuclear body structure, but may rather protect IE2 from proteasome degradation. Aside from functional studies in mammalian cells, we also show that HSPs were stimulated and required to determine IE2 protein levels, in insect cells infected with baculovirus. Upon inhibiting the expression of heat shock proteins, baculovirus IE2 was substantially suppressed, resulting in a significantly suppressed viral titer. Thus, we demonstrate a unique feature in that IE2 can function in both insect and non-host mammalian cells to stimulate HSPs, which may be associated with IE2 stabilization and lead to the protection of the its strong gene activation function in mammalian cells. On the other hand, during viral infection in insect cells, IE2 could also strongly stimulate HSPs and

  10. Feasibility study of the IE-SASW method for nondestructive evaluation of containment building structures in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D.S. E-mail: dskim@kaist.ac.kr; Kim, H.W. E-mail: hwk@kaist.ac.kr; Seo, W.S.; Choi, K.C.; Woo, S.K

    2003-02-01

    The IE-SASW method, a combination of impact-echo (IE) acoustics with spectral analysis of surface waves (SASW), is proposed as a newly developed nondestructive testing method in concrete structures. This feasibility study examines the IE technique and uses elastic P-wave velocity data as measured from the SASW method on concrete members in nuclear power plant containment structures. It was shown that both the thickness of the concrete specimens used in this study and the depth of the introduced defects (i.e. voids) could be identified by the IE-SASW method. In contrast, the reinforced steel bar itself could not be identified by the IE-SASW method. Additionally, GPR (ground penetrating radar) techniques were used to examine the same specimens in order to establish some level of performance and reliability to compare with the performance of the IE-SASW method. The GPR method provides an objective and reliable image corresponding to the reinforced steel bars. The experimental studies show that it is more feasible to use the IE-SASW method rather than GPR to detect voids that were positioned beneath the steel reinforcing bars in the concrete specimens.

  11. Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function

    International Nuclear Information System (INIS)

    Albrecht, Randy A.; Jang, Hyung K.; Kim, Seong K.; O'Callaghan, Dennis J.

    2003-01-01

    Recently, we reported that the immediate-early (IE) protein of equine herpesvirus 1 (EHV-1) associates with transcription factor TFIIB [J. Virol. 75 (2001), 10219]. In the current study, the IE protein purified as a glutathione-S-transferase (GST) fusion protein was shown to interact directly with purified TFIIB in GST-pulldown assays. A panel of TFIIB mutants employed in protein-binding assays revealed that residues 125 to 174 within the first direct repeat of TFIIB mediate its interaction with the IE protein. This interaction is physiologically relevant as transient transfection assays demonstrated that (1) exogenous native TFIIB did not perturb IE protein function, and (2) ectopic expression of a TFIIB mutant that lacked the IE protein interactive domain significantly diminished the ability of the IE protein to trans-activate EHV-1 promoters. These results suggest that an interaction of the IE protein with TFIIB is an important aspect of the regulatory role of the IE protein in the trans-activation of EHV-1 promoters

  12. 76 FR 52313 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-08-22

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-570-803] Heavy Forged Hand Tools (i.e... Administration, Department of Commerce. SUMMARY: As a result of the determinations by the Department of Commerce... on heavy forged hand tools (i.e., [[Page 52314

  13. Developing a Global Model of Accounting Education and Examining IES Compliance in Australia, Japan, and Sri Lanka

    Science.gov (United States)

    Watty, Kim; Sugahara, Satoshi; Abayadeera, Nadana; Perera, Luckmika

    2013-01-01

    The introduction of International Education Standards (IES) signals a clear move by the International Accounting Education Standards Board (IAESB) to ensure high quality standards in professional accounting education at a global level. This study investigated how IES are perceived and valued by member bodies and academics in three counties:…

  14. Evaluation on the Effects of Culture Medium on Regeneration of Oil Palm Plantlets from Immature Embryos (IE)

    International Nuclear Information System (INIS)

    Wan Nur Syuhada, W.S.; Rasid, O.A.; Parveez, G.K.A

    2016-01-01

    Oil palm (Elaeis guineensis) tissue culture is slow, inefficient and genotype dependent. Therefore, efforts to improve the regeneration system are essential and thereby on-going. Immature embryos (IE) have been reported to be more responsive to in vitro culture as compared to other explant types. The objective of this study is to evaluate the most efficient culture media for the regeneration of whole plants from IE. IE were cultured on three media, namely N6, MY3 and MS +Y3. Initial observation showed that calli were induced as early as two weeks after culture. They started to produce friable calli around three to four months later. IE were shown to respond differently to the tested culture media. This initial result will be useful to identify the most responsive culture media for IE as explant. (author)

  15. Consumption of Bt Maize Pollen Containing Cry1Ie Does Not Negatively Affect Propylea japonica (Thunberg (Coleoptera: Coccinellidae

    Directory of Open Access Journals (Sweden)

    Yonghui Li

    2017-03-01

    Full Text Available Propylea japonica (Thunberg (Coleoptera: Coccinellidae are prevalent predators and pollen feeders in East Asian maize fields. They are therefore indirectly (via prey and directly (via pollen exposed to Cry proteins within Bt-transgenic maize fields. The effects of Cry1Ie-producing transgenic maize pollen on the fitness of P. japonica was assessed using two dietary-exposure experiments in the laboratory. In the first experiment, survival, larval developmental time, adult fresh weight, and fecundity did not differ between ladybirds consuming Bt or non-Bt maize pollen. In the second experiment, none of the tested lethal and sublethal parameters of P. japonica were negatively affected when fed a rapeseed pollen-based diet containing Cry1Ie protein at 200 μg/g dry weight of diet. In contrast, the larval developmental time, adult fresh weight, and fecundity of P. japonica were significantly adversely affected when fed diet containing the positive control compound E-64. In both experiments, the bioactivity of the Cry1Ie protein in the food sources was confirmed by bioassays with a Cry1Ie-sensitive lepidopteran species. These results indicated that P. japonica are not affected by the consumption of Cry1Ie-expressing maize pollen and are not sensitive to the Cry1Ie protein, suggesting that the growing of Bt maize expressing Cry1Ie protein will pose a negligible risk to P. japonica.

  16. Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.

    Directory of Open Access Journals (Sweden)

    Xi-Juan Liu

    2017-07-01

    Full Text Available Congenital human cytomegalovirus (HCMV infection is the leading cause of neurological disabilities in children worldwide, but the mechanisms underlying these disorders are far from well-defined. HCMV infection has been shown to dysregulate the Notch signaling pathway in human neural progenitor cells (NPCs. As an important downstream effector of Notch signaling, the transcriptional regulator Hairy and Enhancer of Split 1 (Hes1 is essential for governing NPC fate and fetal brain development. In the present study, we report that HCMV infection downregulates Hes1 protein levels in infected NPCs. The HCMV 72-kDa immediate-early 1 protein (IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase, followed by proteasomal degradation of Hes1. Sp100A, an important component of PML nuclear bodies, is identified to be another target of IE1-mediated ubiquitination. A C-terminal acidic region in IE1, spanning amino acids 451 to 475, is required for IE1/Hes1 physical interaction and IE1-mediated Hes1 ubiquitination, but is dispensable for IE1/Sp100A interaction and ubiquitination. Our study suggests a novel mechanism linking downregulation of Hes1 protein to neurodevelopmental disorders caused by HCMV infection. Our findings also complement the current knowledge of herpesviruses by identifying IE1 as the first potential HCMV-encoded E3 ubiquitin ligase.

  17. The Rotter I-E scale as a predictor of relapse in a population of compulsive gamblers.

    Science.gov (United States)

    Johnson, E E; Nora, R M; Bustos, N

    1992-06-01

    Profile surveys, completed Rotter I-E scales, and questionnaires on past relapse behavior were collected from 108 New Jersey compulsive gamblers who attended Gamblers Anonymous, and an attempt was made, based on the findings, to predict incidence of compulsive gamblers' relapse. Relationships between I-E scores and extent of relapse-free periods, and I-E scores and relapse, with the variables of religious background, age, marital status, education, type of work, and childhood physical abuse were investigated. In every instance the relationship found was statistically non-significant.

  18. Closeout of IE Bulletin 79-12: short-period scrams at boiling-water reactors. Final report

    International Nuclear Information System (INIS)

    DeBevac, C.J.; Holland, R.A.

    1985-03-01

    IE Circular 77-07 was issued on April 14, 1977 because of the occurrence of short period scram events at Dresden Unit 2 on December 28, 1976 and at Monticello on February 23, 1977. The circular advised BWR plants to revise their control rod withdrawal sequences and operating procedures to reduce the likelihood of future short period scrams. However, similar events continued to occur. These included events at Oyster Creek on December 14, 1978; at Browns Ferry Unit 1 on January 18, 1979; and at Hatch Unit 1 on January 31, 1979. As a result of these events, IE Bulletin 79-12 was issued on May 31, 1979. This bulletin required a written response from licensees of GE-designed BWRs regarding specific actions listed in the bulletin. All of the licensees responded in a satisfactory manner. No similar events have been reported since IE Bulletin 79-12 was issued

  19. Cobra-IE Evaluation by Simulation of the NUPEC BWR Full-Size Fine-Mesh Bundle Test (BFBT)

    International Nuclear Information System (INIS)

    Burns, C. J.; Aumiler, D.L.

    2006-01-01

    The COBRA-IE computer code is a thermal-hydraulic subchannel analysis program capable of simulating phenomena present in both PWRs and BWRs. As part of ongoing COBRA-IE assessment efforts, the code has been evaluated against experimental data from the NUPEC BWR Full-Size Fine-Mesh Bundle Tests (BFBT). The BFBT experiments utilized an 8 x 8 rod bundle to simulate BWR operating conditions and power profiles, providing an excellent database for investigation of the capabilities of the code. Benchmarks performed included steady-state and transient void distribution, single-phase and two-phase pressure drop, and steady-state and transient critical power measurements. COBRA-IE effectively captured the trends seen in the experimental data with acceptable prediction error. Future sensitivity studies are planned to investigate the effects of enabling and/or modifying optional code models dealing with void drift, turbulent mixing, rewetting, and CHF

  20. Advanced dexterous manipulation for IED defeat : report on the feasibility of using the ShadowHand for remote operations.

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Robert J.

    2011-01-01

    Improvised Explosive Device (IED) defeat (IEDD) operations can involve intricate operations that exceed the current capabilities of the grippers on board current bombsquad robots. The Shadow Dexterous Hand from the Shadow Robot Company or 'ShadowHand' for short (www.shadowrobot.com) is the first commercially available robot hand that realistically replicates the motion, degrees-of-freedom and dimensions of a human hand (Figure 1). In this study we evaluate the potential for the ShadowHand to perform potential IED defeat tasks on a mobile platform.

  1. Stability of UOP IONSIV/256 IE-911 in SRS simulated salt solution at elevated temperature and subjected to radiation exposure

    International Nuclear Information System (INIS)

    Wilmarth, W.R.

    1999-01-01

    Use of Crystalline Silicotitanate (CST) to remove cesium represents one of the alternatives identified for High Level Waste pretreatment at the Savannah River Site. This report contains a description of the pluggage of the IONSIV(R) IE-911 column prior to a test with actual waste samples

  2. The Impact of Inclusive Education (IE) on the Rights of Children with Intellectual Disabilities (IDs) in Chegutu

    Science.gov (United States)

    Mapuranga, Barbra; Dumba, Oswald; Musodza, Blessing

    2015-01-01

    This study investigated the impact of Inclusive Education (IE) on the rights of children with Intellectual Disabilities in schools around Chegutu. The qualitative case study method was used for the research. Questionnaires and interviews were used to collect data from schools around Chegutu. Random sampling was used to choose the sample group from…

  3. Baculovirus proteins IE-1, LEF-3, and P143 interact with DNA in vivo: a formaldehyde cross-linking study

    International Nuclear Information System (INIS)

    Ito, Emma; Sahri, Daniela; Knippers, Rolf; Carstens, Eric B.

    2004-01-01

    IE-1, LEF-3, and P143 are three of six proteins encoded by Autographa californica nucleopolyhedrovirus (AcMNPV) essential for baculovirus DNA replication in transient replication assays. IE-1 is the major baculovirus immediate early transcription regulator. LEF-3 is a single-stranded DNA binding protein (SSB) and P143 is a DNA helicase protein. To investigate their interactions in vivo, we treated AcMNPV-infected Spodoptera frugiperda cells with formaldehyde and separated soluble proteins from chromatin by cell fractionation and cesium chloride equilibrium centrifugation. Up to 70% of the total LEF-3 appeared in the fraction of soluble, probably nucleoplasmic proteins, while almost all P143 and IE-1 were associated with viral chromatin in the nucleus. This suggests that LEF-3 is produced in quantities that are higher than needed for the coverage of single stranded regions that arise during viral DNA replication and is consistent with the hypothesis that LEF-3 has other functions such as the localization of P143 to the nucleus. Using a chromatin immunoprecipitation procedure, we present the first direct evidence of LEF-3, P143, and IE-1 proteins binding to closely linked sites on viral chromatin in vivo, suggesting that they may form replication complexes on viral DNA in infected cells

  4. 76 FR 24856 - Heavy Forged Hand Tools (i.e., Axes & Adzes, Bars & Wedges, Hammers & Sledges, and Picks...

    Science.gov (United States)

    2011-05-03

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-570-803] Heavy Forged Hand Tools (i.e... Administration, International Trade Administration, Department of Commerce. SUMMARY: On January 3, 2011, the Department of Commerce (``Department'') initiated a sunset review of the antidumping duty orders on heavy...

  5. Use of fault tree technique to determine the failure probability of electrical systems of IE class in nuclear installations

    International Nuclear Information System (INIS)

    Cruz S, W.D.

    1988-01-01

    This paper refers to emergency safety systems of Angra INPP (Brazil 1626 Mw(e)) such as containment, heat removal, emergency removal system, radioactive elements removal from containment environment, berated water infection, etc. Associated with these systems, the failure probability calculation of IE Class bars is achieved, this is a safety classification for electrical equipment essential for the systems mentioned above

  6. Mixed Methods in Education Research. IES Technical Working Group Meeting. Meeting Summary (Washington, DC, May 29, 2015)

    Science.gov (United States)

    Institute of Education Sciences, 2015

    2015-01-01

    This meeting summary is organized into two major sections. The first section captures the individual contribution of meeting participants, including both Institute of Education Sciences (IES) staff and the invited technical working group members. The second section captures themes that arose during the group discussions, which were organized…

  7. Porcine models of non-bacterial thrombotic endocarditis (NBTE) and infective endocarditis (IE) caused by Staphylococcus aureus: a preliminary study.

    Science.gov (United States)

    Christiansen, Johanna G; Jensen, Henrik E; Johansen, Louise K; Kochl, Janne; Koch, Jørgen; Aalbaek, Bent; Nielsen, Ole L; Leifsson, Páll S

    2013-05-01

    Non-bacterial thrombotic endocarditis (NBTE) and, in particular, infective endocarditis (IE), are serious and potentially life-threatening diseases. An increasingly important agent of human IE is Staphylococcus aureus, which typically causes an acute endocarditis with high mortality. The study aim was to evaluate the pig as a model for non-bacterial as well as S. aureus-associated endocarditis, as these models would have several advantages compared to other laboratory animal models. Fourteen animals underwent surgery with placement of a plastic catheter in the left side of the heart. Six of the pigs did not receive a bacterial inoculation and were used to study the development of NBTE. The remaining eight pigs were inoculated intravenously once or twice with S. aureus, 10(5)-10(7) cfu/kg body weight. Two bacterial strains were used: S54F9 (porcine) and NCTC8325-4 (human). Clinical examination, echocardiography and bacterial blood cultures were used to diagnose and monitor the development of endocarditis. Animals were euthanized at between two and 15 days after catheter placement, and tissue samples were collected for bacteriology and histopathology. Pigs inoculated with 10(7) cfu/kg of S. aureus strain S54F9 developed clinical, echocardiographic and pathologic signs of IE. All other pigs, except one, developed NBTE. Serial blood cultures withdrawn after inoculation were positive in animals with IE, and negative in all other animals. S. aureus endocarditis was successfully induced in pigs with an indwelling cardiac catheter after intravenous inoculation of 10(7) cfu/kg of S. aureus strain S54F9. The model simulates typical pathological, clinical and diagnostic features seen in the human disease. Furthermore, NBTE was induced in all but one of the pigs without IE. Thus, the pig model can be used in future studies of the pathogenesis, diagnosis and therapy of NBTE and S. aureus endocarditis.

  8. The need for combining IEA and IE tools. The potential effects of a global ban on PVC on climate change

    International Nuclear Information System (INIS)

    Kleijn, Rene; Van der Voet, Ester; Udo de Haes, Helias A.

    2008-01-01

    Over the last decades the concepts of Integrated Environmental Assessment (IEA) and Industrial Ecology (IE), both claiming to provide analyses and solutions for sustainability issues, have been developed separately as they emerged in response to questions from different policy-fields. In both fields, specific tools are used to support national and international environmental policy. The focus of IEA and IE tools, however, is different. IEA tools focus on one or a limited number of specific environmental issues. They often model the chain environmental processes with high spatial (and temporal) resolution, but have a low resolution for the material structure of the economy and only partly take into account indirect effects that occur via physical and socio-economic linkages. IE tools take into account all environmental issues related to a specific substance or product. They have a high resolution for the material structure of the economy and take into account indirect effects that occur via physical linkages, however, their environmental modelling is very limited. Both IE and IEA tools have proven to be very useful and neither is superior to the other. However, a combination of both can provide additional information that can be used for more effective policy making. We use the case of a hypothetical world-wide ban on PVC to show that a measure that is not directly related to climate change could still have significant climate effects. This indirect effect is a result of the linkages of material flows in society. We show that IEA tools are not well suited to include these types of effects and that IE tools can fill this gap partially. What is really needed is a broader systems perspective that takes into account the full range of possible side-effects of environmental policy measures. (author)

  9. Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

    Science.gov (United States)

    Müller-Redetzky, Holger C; Felten, Matthias; Hellwig, Katharina; Wienhold, Sandra-Maria; Naujoks, Jan; Opitz, Bastian; Kershaw, Olivia; Gruber, Achim D; Suttorp, Norbert; Witzenrath, Martin

    2015-01-28

    Lung-protective ventilation reduced acute respiratory distress syndrome (ARDS) mortality. To minimize ventilator-induced lung injury (VILI), tidal volume is limited, high plateau pressures are avoided, and positive end-expiratory pressure (PEEP) is applied. However, the impact of specific ventilatory patterns on VILI is not well defined. Increasing inspiratory time and thereby the inspiratory/expiratory ratio (I:E ratio) may improve oxygenation, but may also be harmful as the absolute stress and strain over time increase. We thus hypothesized that increasing inspiratory time and I:E ratio aggravates VILI. VILI was induced in mice by high tidal-volume ventilation (HVT 34 ml/kg). Low tidal-volume ventilation (LVT 9 ml/kg) was used in control groups. PEEP was set to 2 cm H2O, FiO2 was 0.5 in all groups. HVT and LVT mice were ventilated with either I:E of 1:2 (LVT 1:2, HVT 1:2) or 1:1 (LVT 1:1, HVT 1:1) for 4 hours or until an alternative end point, defined as mean arterial blood pressure below 40 mm Hg. Dynamic hyperinflation due to the increased I:E ratio was excluded in a separate group of animals. Survival, lung compliance, oxygenation, pulmonary permeability, markers of pulmonary and systemic inflammation (leukocyte differentiation in lung and blood, analyses of pulmonary interleukin-6, interleukin-1β, keratinocyte-derived chemokine, monocyte chemoattractant protein-1), and histopathologic pulmonary changes were analyzed. LVT 1:2 or LVT 1:1 did not result in VILI, and all individuals survived the ventilation period. HVT 1:2 decreased lung compliance, increased pulmonary neutrophils and cytokine expression, and evoked marked histologic signs of lung injury. All animals survived. HVT 1:1 caused further significant worsening of oxygenation, compliance and increased pulmonary proinflammatory cytokine expression, and pulmonary and blood neutrophils. In the HVT 1:1 group, significant mortality during mechanical ventilation was observed. According to the "baby lung

  10. Competências de marketing exigidas para os gestores de Instituições de Ensino Superior (IES

    Directory of Open Access Journals (Sweden)

    Marconi Freitas-da-Costa

    2011-04-01

    Full Text Available Este trabalho tem como objetivo identificar as competências de marketing dos gestores de duas Instituições de Ensino Superior (IES, sendo uma pública e uma privada, fazendo um paralelo entre os conhecimentos de cada gestor com a teoria do marketing. Para a realização deste artigo utilizaram-se pesquisas exploratórias, pesquisa qualitativa e estudo de dois casos, através de uma entrevista semiestruturada. De acordo com a pesquisa, foi possível constatar que as IES tanto pública quanto privada utilizam o marketing, porém de formas diferenciadas. Enquanto a primeira utiliza algumas ferramentas do assunto, a segunda as utiliza de maneira mais aprofundada e com maior profissionalismo.

  11. Versão brasileira da Impact of Event Scale (IES: tradução e adaptação transcultural Brazilian version of the Impact of Event Scale (IES: translation and cross-cultural adaptation

    Directory of Open Access Journals (Sweden)

    Adriana Cardoso de Oliveira e Silva

    2010-01-01

    Full Text Available INTRODUÇÃO: A Impact of Event Scale (IES tem como proposta avaliar o estresse subjetivo relacionado a eventos de vida, não estando focada em uma situação específica, mas nas características particulares que envolvem tais eventos. OBJETIVO: Descrever a tradução e adaptação semântica da IES para o português brasileiro. MÉTODO: O processo foi realizado por meio de duas traduções e retrotraduções, elaboradas por quatro avaliadores independentes e sem conhecimento prévio da escala original. A elaboração da versão sintética foi realizada por especialista em saúde mental bilíngue. Procedeu-se a posterior aplicação em grupo experimental para avaliação dos itens. A versão gerada foi enviada para aprovação do autor do instrumento original, obtendo-se resposta positiva. RESULTADOS: Todas as etapas do processo, incluindo traduções, retrotraduções e a versão sintética elaborada, são apresentadas para cada um dos 15 itens do instrumento original. O especialista em saúde mental colaborou para a adequação dos termos utilizados em relação ao construto medido. Através da aplicação experimental, foi possível identificar potenciais pontos de dificuldade para o entendimento de itens específicos e realizar ajustes posteriores. Foram obtidos 15 itens em português brasileiro para compor essa versão da escala. CONCLUSÕES: A partir da metodologia utilizada, foi possível elaborar a adaptação transcultural da IES para o português brasileiro.INTRODUCTION: The aim of the Impact of Event Scale (IES is to evaluate subjective distress associated with life events. The instrument is not focused on a specific situation, but rather on the particular characteristics of such events. OBJECTIVE: To describe the translation and semantic adaptation of the IES into Brazilian Portuguese. METHODS: The process consisted of translations and back-translations performed by four independent examiners without prior knowledge of the original

  12. Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

    Science.gov (United States)

    Smith, Clyde A; Toth, Marta; Bhattacharya, Monolekha; Frase, Hilary; Vakulenko, Sergei B

    2014-06-01

    The bifunctional acetyltransferase(6')-Ie-phosphotransferase(2'')-Ia [AAC(6')-Ie-APH(2'')-Ia] is the most important aminoglycoside-resistance enzyme in Gram-positive bacteria, conferring resistance to almost all known aminoglycoside antibiotics in clinical use. Owing to its importance, this enzyme has been the focus of intensive research since its isolation in the mid-1980s but, despite much effort, structural details of AAC(6')-Ie-APH(2'')-Ia have remained elusive. The structure of the Mg2GDP complex of the APH(2'')-Ia domain of the bifunctional enzyme has now been determined at 2.3 Å resolution. The structure of APH(2'')-Ia is reminiscent of the structures of other aminoglycoside phosphotransferases, having a two-domain architecture with the nucleotide-binding site located at the junction of the two domains. Unlike the previously characterized APH(2'')-IIa and APH(2'')-IVa enzymes, which are capable of utilizing both ATP and GTP as the phosphate donors, APH(2'')-Ia uses GTP exclusively in the phosphorylation of the aminoglycoside antibiotics, and in this regard closely resembles the GTP-dependent APH(2'')-IIIa enzyme. In APH(2'')-Ia this GTP selectivity is governed by the presence of a `gatekeeper' residue, Tyr100, the side chain of which projects into the active site and effectively blocks access to the adenine-binding template. Mutation of this tyrosine residue to a less bulky phenylalanine provides better access for ATP to the NTP-binding template and converts APH(2'')-Ia into a dual-specificity enzyme.

  13. Strategy BMT Al-Ittihad Using Matrix IE, Matrix SWOT 8K, Matrix SPACE and Matrix TWOS

    Directory of Open Access Journals (Sweden)

    Nofrizal Nofrizal

    2018-03-01

    Full Text Available This research aims to formulate and select BMT Al-Ittihad Rumbai strategy to face the changing of business environment both from internal environment such as organization resources, finance, member and external business such as competitor, economy, politics and others. This research method used Analysis of EFAS, IFAS, IE Matrix, SWOT-8K Matrix, SPACE Matrix and TWOS Matrix. our hope from this research it can assist BMT Al-Ittihad in formulating and selecting strategies for the sustainability of BMT Al-Ittihad in the future. The sample in this research is using purposive sampling technique that is the manager and leader of BMT Al-IttihadRumbaiPekanbaru. The result of this research shows that the position of BMT Al-Ittihad using IE Matrix, SWOT-8K Matrix and SPACE Matrix is in growth position, stabilization and aggressive. The choice of strategy after using TWOS Matrix is market penetration, market development, vertical integration, horizontal integration, and stabilization (careful.

  14. Quadriceps strength, inter-extremity difference (IED) and joint status in adult persons with severe haemophilia in different age stages.

    Science.gov (United States)

    Brunner, A; Stäuber, F; Göhler, S; Czepa, D; Krüger, S; Wendel, M; Seuser, A; Hilberg, T

    2013-03-01

    Quadriceps weakness seems to be a hallmark in adult persons with severe haemophilia (PWH). The purpose of this study was to compare PWH and non-haemophilic controls in different age stages with reference to joint status and quadriceps strength. Further aims were to examine the extent of strength-specific inter-extremity-difference (IED) and the prevalence of abnormal IED (AIED). A total of 106 adults with severe haemophilia (H) and 80 controls (C) had undergone an orthopaedic examination for classification of knee and ankle status using the WFH score. Quadriceps strength was evaluated unilaterally as well as bilaterally with a knee extensor device. Each group was divided into four age-related subgroups (HA/CA: 18-29, HB/CB: 30-39, HC/CC: 40-49, HD/CD: 50-70; in years). H presented a worse knee and ankle status than C indicated by higher WFH scores (P age-matched subgroups only HB showed higher knee scores than CB (P age-matched controls (P age in H. We discovered an AIED in 35% of H. These findings highlight the importance for the early implementation of preventive and rehabilitative muscle training programmes in the comprehensive treatment of PWH. © 2012 Blackwell Publishing Ltd.

  15. Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein

    Directory of Open Access Journals (Sweden)

    April Pawluk

    2017-12-01

    Full Text Available CRISPR (clustered regularly interspaced short palindromic repeat-Cas adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They provide sequence-specific detection and neutralization of foreign nucleic acids such as bacteriophages and plasmids. One mechanism by which phages and other mobile genetic elements are able to overcome the CRISPR-Cas system is through the expression of anti-CRISPR proteins. Over 20 different families of anti-CRISPR proteins have been described, each of which inhibits a particular type of CRISPR-Cas system. In this work, we determined the structure of type I-E anti-CRISPR protein AcrE1 by X-ray crystallography. We show that AcrE1 binds to the CRISPR-associated helicase/nuclease Cas3 and that the C-terminal region of the anti-CRISPR protein is important for its inhibitory activity. We further show that AcrE1 can convert the endogenous type I-E CRISPR system into a programmable transcriptional repressor.

  16. Infrared and optical pulsations from HZ hercules and possible 3.5 second infrared pulsations from IE 2259+586

    International Nuclear Information System (INIS)

    Middleditch, J.; Pennypacker, C.R.; Burns, M.S.

    1983-01-01

    The spectrum of the pulsed optical and infrared flux from HZ Her has been measured to be flat by simultaneous observations with the NASA IRTF 3.0 m and the Lick Crossley 91 cm telescopes. The pulsed fluxes in the 3200-7500 A bandpass and the 1.0-2.5 μm bandpass were both measured to be consistent with 27 μJy and indicate that the reprocessed pulsation spectrum may be optically thin thermal bremsstrahlung radiation, modulated in intensity. However, the temperature required for a good fit is > or =30,000 K. The results of a search for periodic infrared pulsations from other X-ray and radio pulsars, supernova remnants, and the galactic center source IRS 16, are also reported. We have possibly detected 3.5 s infrared pulsations from the X-ray binary pulsar, IE 2259+586. The 285.7 mHz infrared pulsation frequency from IE 2259+586 is consistent with the 286.6 mHz second harmonic X-ray pulsations reprocessed from a companion star in the close binary orbit whose period has been tentatively established to be approx.2300 s

  17. Presenting Your Best Self(ie): The Influence of Gender on Vertical Orientation of Selfies on Tinder.

    Science.gov (United States)

    Sedgewick, Jennifer R; Flath, Meghan E; Elias, Lorin J

    2017-01-01

    When taking a self-portrait or "selfie" to display in an online dating profile, individuals may intuitively manipulate the vertical camera angle to embody how they want to be perceived by the opposite sex. Concepts from evolutionary psychology and grounded cognition suggest that this manipulation can provide cues of physical height and impressions of power to the viewer which are qualities found to influence mate-selection. We predicted that men would orient selfies more often from below to appear taller (i.e., more powerful) than the viewer, and women, from an above perspective to appear shorter (i.e., less powerful). A content analysis was conducted which coded the vertical orientation of 557 selfies from profile pictures on the popular mobile dating application, Tinder. In general, selfies were commonly used by both men (54%) and women (90%). Consistent with our predictions, a gender difference emerged; men's selfies were angled significantly more often from below, whereas women's were angled more often from above. Our findings suggest that selfies presented in a mate-attraction context are intuitively or perhaps consciously selected to adhere to ideal mate qualities. Further discussion proposes that biological or individual differences may also facilitate vertical compositions of selfies.

  18. Presenting Your Best Self(ie: The Influence of Gender on Vertical Orientation of Selfies on Tinder

    Directory of Open Access Journals (Sweden)

    Lorin J. Elias

    2017-04-01

    Full Text Available When taking a self-portrait or “selfie” to display in an online dating profile, individuals may intuitively manipulate the vertical camera angle to embody how they want to be perceived by the opposite sex. Concepts from evolutionary psychology and grounded cognition suggest that this manipulation can provide cues of physical height and impressions of power to the viewer which are qualities found to influence mate-selection. We predicted that men would orient selfies more often from below to appear taller (i.e., more powerful than the viewer, and women, from an above perspective to appear shorter (i.e., less powerful. A content analysis was conducted which coded the vertical orientation of 557 selfies from profile pictures on the popular mobile dating application, Tinder. In general, selfies were commonly used by both men (54% and women (90%. Consistent with our predictions, a gender difference emerged; men's selfies were angled significantly more often from below, whereas women's were angled more often from above. Our findings suggest that selfies presented in a mate-attraction context are intuitively or perhaps consciously selected to adhere to ideal mate qualities. Further discussion proposes that biological or individual differences may also facilitate vertical compositions of selfies.

  19. Geochemistry of hot springs in the Ie Seu’um hydrothermal areas at Aceh Besar district, Indonesia

    Science.gov (United States)

    Idroes, R.; Yusuf, M.; Alatas, M.; Subhan; Lala, A.; Saiful; Suhendra, R.; Idroes, G. M.; Marwan

    2018-03-01

    Indonesia geothermal resources are the largest in the world, about 40 percent of the total geothermal resources worldwide with a potential energy of 28,617 MW. Geothermal energy is one of the renewable energy in the world that can be developed sustainably. This kind of energy is not only environmentally friendly but also highly prospective compared to fossil energy. One of the potential geothermal energy in Indonesia is Seulawah Agam geothermal field with some manifestation areas. The fluid type of Ie Seu’um manifestation was chloride (Cl-) obtained from the ternary diagram Cl--SO4 2--HCO3 -, using UV-Vis spectrophotometry, argentometry and acidimetry method. The reservoir range temperature was 188,7 ± 9,3°C calculated using geothermometer Na-K-Ca, Na-K Fournier and Na-K Giggenbach by applying Atomic Absorption Spectroscopy method. This data processing was carried out using liquid chemistry plotting spreadsheet version 3 powell geoscience Ltd.3 September 2012 by Powell & Cumming. The potential in the geothermal manifestation of Ie Seu’um was estimated about 50-100 MW (medium enthalpy).

  20. COMPETENŢA DE INVESTIGAŢIE, IMPERATIV AL SOCIETĂŢII AXATE PE CUNOAŞTERE

    Directory of Open Access Journals (Sweden)

    Nina BÎRNAZ

    2015-11-01

    Full Text Available Contextul amplelor schimbări tehnologice determină specificul societăţii axate pe cunoaştere. Politicile cunoaşterii, în acest context, se referă la cercetare, inovaţie, educaţie şi la formarea profesională; politicile educaţionale se referă la trecerea progresivă de la behaviorism spre pragmatism, şi anume: de la acţiune în baza analogiilor, fără implicarea con-ştiinţei (teoria behavioristă la acţiune de cercetare care presupune rezolvarea problemelor din viaţă. Educaţia elevilor, în acest context, presupune nu doar achiziţii teoretice, dar şi formarea unui spirit de investigaţie, necesar pentru partici-parea activă la locul său în comunitate. Din această perspectivă, curriculumul şcolar promovează abordarea unui demers educaţional axat pe competenţe, prin prisma corelaţiei: iniţiativa profesorului – acţiunea elevului („learning by doing”. INVESTIGATION SKILL, KEY ELEMENT OF A SOCIETY CENTERED ON LEARNINGThe context of ample technological advances determines the specifics of a society centered on learning. The learning politics, in this context are referred to research, innovation, education and professional training; the educational politics refer to the progressive transition from behaviorism towards pragmatism, especially from actions based on analogies, without the implication of conscience (the behavioral theory in research, which implies the solving of life’s problems. The education of students, in this context, implies not just theoretical acquirement, but also the forming of a spirit of investigating, needed for an active participation in its place or inside the community. From this perspective, the school curriculum promotes the approach of an educational step based on skills, linking the teacher’s initiative with the student’s action (learning by doing.

  1. Thermal and Physical Property Determinations for Ionsiv IE-911 Crystalline Silicotitanate and Savannah River Site Waste Simulant Solutions

    International Nuclear Information System (INIS)

    Bostick, D.T.; Steele, W.V.

    1999-01-01

    This document describes physical and thermophysical property determinations that were made in order to resolve questions associated with the decontamination of Savannah River Site (SRS) waste streams using ion exchange on crystalline silicotitanate (CST). The research will aid in the understanding of potential issues associated with cooling of feed streams within SRS waste treatment processes. Toward this end, the thermophysical properties of engineered CST, manufactured under the trade name, Ionsivereg s ign IE-911 by UOP, Mobile, AL, were determined. The heating profiles of CST samples from several manufacturers' production runs were observed using differential scanning calorimetric (DSC) measurements. DSC data were obtained over the region of 10 to 215 C to check for the possibility of a phase transition or any other enthalpic event in that temperature region. Finally, the heat capacity, thermal conductivity, density, viscosity, and salting-out point were determined for SRS waste simulants designated as Average, High NO 3 - and High OH - simulants

  2. Does modifying the particle size distribution of a granular material (i.e., material scalping alters its shear strength?

    Directory of Open Access Journals (Sweden)

    Azéma Emilien

    2017-01-01

    Full Text Available By means of two dimensional contact dynamics simulations, we analyzed the effect of the particle size distribution (PSD on the shear strength of granular materials composed of un-breakable disks. We modelled PSDs with a normalized beta function, which allows for building S-shaped gradation curves, such as those that typically occur in soils. We systematically controlled and varied the size span and the shape of the PSD, and found that the shear strength is independent both characteristics. This implies that PSD modification procedures such as material scalping (i.e., removing the smallest and/or largest particles in the sample should not affect significantly the shear strength of the material composed of unbreakable discs. In order to explore the origins of the invariance of the shear strength with PSD, we analyzed the connectivity, force transmission, and friction mobilization in terms of anisotropies, finding that the constant shear strength is due to a subtle compensation of anisotropies.

  3. Zemes izmantošanu ietekmējošie faktori 20.gs. Latvijā

    OpenAIRE

    Līkosts, Valdis

    2009-01-01

    Maģistra darbā tiek analizēta lauksaimniecībā izmantojamo zemju apsaimniekojuma struktūra divos Rietumkurzemes augstienes pagastos. Zemes izmantošanu ietekmējošo faktoru ietekmju izvērtēšanai tika izmantota zemju apsaimniekošanas datu statistiskā apstrāde, aprēķinot faktoru ietekmju lielumu un nosakot to būtiskumu. Faktoru analīzes rezultātā tika konstatēts, ka zemes izmantošanu un ainavas dinamiku, šie faktori ietekmē. Faktoru ietekmei piemīt spēcīga mainība gan telpiskā, gan temporālā m...

  4. DIAGNÓSTICO DE LAS CONCEPCIONES SOBRE REPRODUCCIÓN CELULAR EN ESTUDIANTES DE GRADO SÉPTIMO, OCTAVO Y NOVENO DE LOS COLEGIOS MIGUEL ANTONIO CARO IED Y JUSTO VÍCTOR CHARRY IED

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Pineda Amórtegui

    2016-10-01

    Full Text Available El siguiente artículo da cuenta de los resultados obtenidos de la aplicación de una evaluación diagnóstica sobre reproducción celular en estudiantes de grado séptimo, octavo y noveno de los colegios Miguel Antonio Caro IED y Justo Víctor Charry IED, jornada tarde. El manejo de estos conceptos es primordial para que los estudiantes lleguen a comprender otras temáticas importantes dentro de la biología como lo son la genética, al entender los procesos de transmisión de caracteres hereditarios; la evolución de los seres vivos desde la variabilidad, la selección natural y la preservación de las especies; y en la biología del desarrollo, al reconocer la mitosis como proceso para la formación de un nuevo ser a partir de divisiones sucesivas de las células; entre otros. Este es un trabajo de investigación mixta, a través de la aplicación de un cuestionario con preguntas de selección múltiple con única respuesta, acompañado de una entrevista. El análisis de resultados se realizó con relación a número de aciertos, porcentajes de acierto, porcentajes de selección de respuesta y competencias desarrolladas, lo que permitió identificar las bases conceptuales y/o dificultades de los estudiantes frente a la comprensión y aprendizaje de los conceptos relacionados con la reproducción celular, y las falencias en cuanto al desarrollo de competencias en ciencias naturales que le permitan a los estudiantes conocer y actuar con relación a su entorno. Así mismo, se sugiere la planeación y diseño de una estrategia de enseñanza-aprendizaje-evaluación, la cual tome en cuenta las características y necesidades de la población a la que va dirigida, y decida sobre los contenidos a incluir.

  5. EXTEND OPERATION PROBLEMS AND RECONSTRUCTION OF LARGEPANEL FIVE-STOREY BUILDINGS OF 50-60-IES XX CENTURY

    Directory of Open Access Journals (Sweden)

    BOLSHAKOV V. I.,

    2016-01-01

    Full Text Available Raising of the problem. In many regions is utilised housing, that age is more than half a century. According to the research materials of the analytical center of Ukrainian Cities Association there are 25,5 thousand houses built by first mass series project of large, block and brick buildings with a total area of 72 million M2 today in the state, rather those, that require reconstruction and modernization. In general, most of the housing stock of Ukraine is in a poor technical condition due to its deficient funding; it keeps the tendency of premature aging of the housing stock.One of the major problems of modern construction industry is the continuation of housing exploitation, in particular is it the building era of mass construction of 50-60-ies of XX century, called "Khrushchevki". According to the State Statistics Service of Ukraine the deterioration of residential buildings in Ukraine amounts to 47.2%, which makes us think of the immediate actions to occure this situation. The most acceptable way, at first viewe, seems the reconstruction of "Khrushchvki". However, the reconstruction is a complex problem that requires the construction industry solution due to the economic component, the social factor, the views of residents of these homes to create a technological and economical viable result. Analysis of publications. The problem of the "Khrushchevki" reconstruction is the subject of continual researches of leading builders of Ukraine. In the researchers' attention just as the technological problems [1 - 3], so economic components [4 - 6], in general, give an idea of the work scale required to overcome the impending crisis. The purpose of the article. Defining the main problems of exploatation of panel fivestory buildings of 50 - 60-ies twentieth century and their residents thoughts about existing inconvenience, as well as associated economic, technological and legal problems in the implementation of buildings reconstruction. Conclusions

  6. Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.

    Science.gov (United States)

    Yuan, Junhui; Higuchi, Yujiro; Nagado, Tatsui; Nozuma, Satoshi; Nakamura, Tomonori; Matsuura, Eiji; Hashiguchi, Akihiro; Sakiyama, Yusuke; Yoshimura, Akiko; Takashima, Hiroshi

    2013-03-01

    DNMT1, encoding DNA methyltransferase 1 (Dnmt1), is a critical enzyme which is mainly responsible for conversion of unmethylated DNA into hemimethylated DNA. To date, two phenotypes produced by DNMT1 mutations have been reported, including hereditary sensory and autonomic neuropathy (HSAN) type IE with mutations in exon 20, and autosomal dominant cerebellar ataxia, deafness, and narcolepsy caused by mutations in exon 21. We report a sporadic case in a Japanese patient with loss of pain and vibration sense, chronic osteomyelitis, autonomic system dysfunctions, hearing loss, and mild dementia, but without definite cerebellar ataxia. Electrophysiological studies revealed absent sensory nerve action potential with nearly normal motor nerve conduction studies. Brain magnetic resonance imaging revealed mild diffuse cerebral and cerebellar atrophy. Using a next-generation sequencing system, 16 candidate genes were analyzed and a novel missense mutation, c.1706A>G (p.His569Arg), was identified in exon 21 of DNMT1. Our findings suggest that mutation in exon 21 of DNMT1 may also produce a HSAN phenotype. Because all reported mutations of DNMT1 are concentrated in exons 20 and 21, which encode the replication focus targeting sequence (RFTS) domain of Dnmt1, the RFTS domain could be a mutation hot spot. © 2013 Peripheral Nerve Society.

  7. Structure and properties of heat-treated Ti-(40-4X)%Nb-X%Mo alloys with IE (SME)

    International Nuclear Information System (INIS)

    Silva, Marcia Almeida; Matlakhova, Lioudmila Aleksandrovna; Matlakhov, Anatoliy Nikolaevich; Paes Junior, Herval Ramos; Goncharenko, Boris Andreevich

    2010-01-01

    Whereas the inelastic effects (IE) are related with reversible martensitic transformation, in this work, was analyzed the structure and properties of heat treated Ti-(40-4x)%Nb-x%Mo alloys, where the contents of niobium and molybdenum are between 24-40%Nb and 0-4%Mo (% weight). The structural and phase analysis were done through optical microscopy and X-rays diffraction. The properties measured in this study were electrical resistivity and density. The Ti-40%Nb alloy shows a structure consisting of the β phase and αα’’ martensite with a minor participation of the α’ and ω. The alloys with 1 to 4%Mo have similar structures consisting of the β phase and traces of the α’’ phase. Thus, was observed greater capacity of Mo as a β stabilizer. The increase in Mo content in the composition of the alloys causes an increase in electrical resistivity of these. The samples may have undergone change in volume, caused by phase transformation, what possibly caused the difference between the density values calculated (theoretical) and experimental. (author)

  8. [Advances in molecular mechanisms of adaptive immunity mediated by type I-E CRISPR/Cas system--A review].

    Science.gov (United States)

    Sun, Dongchang; Qiu, Juanping

    2016-01-04

    To better adapt to the environment, prokaryocyte can take up exogenous genes (from bacteriophages, plasmids or genomes of other species) through horizontal gene transfer. Accompanied by the acquisition of exogenous genes, prokaryocyte is challenged by the invasion of 'selfish genes'. Therefore, to protect against the risk of gene transfer, prokaryocyte needs to establish mechanisms for selectively taking up or degrading exogenous DNA. In recent years, researchers discovered an adaptive immunity, which is mediated by the small RNA guided DNA degradation, prevents the invasion of exogenous genes in prokaryocyte. During the immune process, partial DNA fragments are firstly integrated.to the clustered regularly interspaced short palindromic repeats (CRISPR) located within the genome DNA, and then the mature CRISPR RNA transcript and the CRISPR associated proteins (Cas) form a complex CRISPR/Cas for degrading exogenous DNA. In this review, we will first briefly describe the CRISPR/Cas systems and then mainly focus on the recent advances of the function mechanism and the regulation mechanism of the type I-E CRISPR/Cas system in Escherichia coli.

  9. New IES scheme for power conditioning at ultra-high currents: from concept to MHD modeling and first experiments

    International Nuclear Information System (INIS)

    Chuvatin, Alexandre S.; Aranchuk, Leonid E.; Rudakov, Leonid I.; Kokshenev, Vladimir A.; Kurmaev, Nikolai E.; Fursov, Fiodor I.; Huet, Dominique; Gasilov, Vladimir A.; Krukovskii, Alexandre Yu.

    2002-01-01

    This work introduces an inductive energy storage (IES) scheme which aims pulsed-power conditioning at multi- MJ energies. The key element of the scheme represents an additional plasma volume, where a magnetically accelerated wire array is used for inductive current switching. This plasma acceleration volume is connected in parallel to a microsecond capacitor bank and to a 100-ns current ruse-time useful load. Simple estimates suggest that optimized scheme parameters could be reachable even when operating at ultra-high currents. We describe first proof-of-principle experiments carried out on GIT12 generator at the wire-array current level of 2 MA. The obtained confirmation of the concept consists in generation of a 200 kV voltage directly at an inductive load. This load voltage value can be already sufficient to transfer the available magnetic energy into kinetic energy of a liner at this current level. Two-dimensional modeling with the radiational MHD numerical tool Marple confirms the development of inductive voltage in the system. However, the average voltage increase is accompanied by short-duration voltage drops due to interception of the current by the low-density upstream plasma. Upon our viewpoint, this instability of the current distribution represents the main physical limitation to the scheme performance

  10. Closeout of IE Bulletin 80-15: Possible loss of Emergency Notification System (ENS) with loss of offsite power

    International Nuclear Information System (INIS)

    Foley, W.J.; Dean, R.S.; Hennick, A.

    1990-12-01

    Documentation is provided in this report for the closeout of IE Bulletin 80-15 for nuclear power reactors. This bulletin pertained to a possible loss of the Emergency Notification System (ENS) upon loss of offsite power. Closeout is based on the implementation and verification of six (6) required actions by licensees of nuclear power reactors in operation or near to receiving an operating license when the bulletin was issued on June 18, 1980. Evaluation of utility responses and NRC/Region inspection reports indicates that the bulletin is closed for all of the 69 nuclear power reactors to which it was issued for action and which were not shut down indefinitely or permanently at the time of issuance of this report. Background information is supplied in the Introduction and Appendix A. Nuclear fuel facilities as well as nuclear power facilities were identified in the enclosures to the bulletin. However, per an NRC memorandum, the closeout of the bulletin for nuclear fuel facilities is not within the scope of this report

  11. The equine herpesvirus-1 IR3 gene that lies antisense to the sole immediate-early (IE) gene is trans-activated by the IE protein, and is poorly expressed to a protein

    International Nuclear Information System (INIS)

    Ahn, Byung Chul; Breitenbach, Jonathan E.; Kim, Seong K.; O'Callaghan, Dennis J.

    2007-01-01

    The unique IR3 gene of equine herpesvirus 1 (EHV-1) is expressed as a late 1.0-kb transcript. Previous studies confirmed the IR3 transcription initiation site and tentatively identified other cis-acting elements specific to IR3 such as a TATA box, a 443 base pair 5'untranslated region (UTR), a 285 base pair open reading frame (ORF), and a poly adenylation (A) signal [Holden, V.R., Harty, R.N., Yalamanchili, R.R., O'Callaghan, D.J., 1992. The IR3 gene of equine herpesvirus type 1: a unique gene regulated by sequences within the intron of the immediate-early gene. DNA Seq. 3, 143-152]. Transient transfection assays revealed that the IR3 promoter is strongly trans-activated by the IE protein (IEP) and that coexpression of the IEP with the early EICP0 and IR4 regulatory proteins results in maximal trans-activation of the IR3 promoter. Gel shift assays revealed that the IEP directly binds to the IR3 promoter region. Western blot analysis showed that the IR3 protein produced in E. coli was detected by antibodies to IR3 synthetic peptides; however, the IR3 protein was not detected in EHV-1 infected cell extracts by these same anti-IR3 antibodies, even though the IR3 transcript was detected by northern blot. These findings suggest that the IR3 may not be expressed to a protein. Expression of an IR3/GFP fusion gene was not observed, but expression of a GFP/IR3 fusion gene was detected by fluorescent microscopy. In further attempts to detect the IR3/GFP fusion protein using anti-GFP antibody, western blot analysis showed that the IR3/GFP fusion protein was not detected in vivo. Interestingly, a truncated form of the GFP/IR3 protein was synthesized from the GFP/IR3 fusion gene. However, GFP/IR3 and IR3/GFP fusion proteins of the predicted sizes were synthesized by in vitro coupled transcription and translation of the fusion genes, suggesting poor expression of the IR3 protein in vivo. The possible role of the IR3 transcript in EHV-1 infection is discussed

  12. Flow direction variations of low energy ions as measured by the ion electron sensor (IES) flying on board of Rosetta

    Science.gov (United States)

    Szegö, Karoly; Nemeth, Zoltan; Foldy, Lajos; Burch, James L.; Goldstein, Raymond; Mandt, Kathleen; Mokashi, Prachet; Broiles, Tom

    2015-04-01

    The Ion Electron Sensor (IES) simultaneously measures ions and electrons with two separate electrostatic plasma analyzers in the energy range of 4 eV- 22 keV for ions. The field of view is 90ox360o, with angular resolution 5ox45o for ions, with a sector containing the solar wind being further segmented to 5o × 5o. IES has operated continuously since early 2014. In the ion data a low energy (energy ions. Here we analyze the arrival direction of this low energy component. The origin of these low energy ions is certainly the ionized component of the neutral gas emitted due to solar activity from comet 67P/Churiumov-Gerasimenko. The low energy component in general shows a 6h periodicity due to cometary rotation. The data show, however, that the arrival direction of the low energy ions is smeared both in azimuth and elevation, due possibly to the diverse mechanisms affecting these ions. One of these effects is the spacecraft potential (~-10V), which accelerates the ions towards the spacecraft omnidirectionally. To characterize the flow direction in azimuth-elevation, we have integrated over the lowest 8 energy channels using weighted energy: sum(counts * energy)/sum(counts); and considered only cases when the counts are above 30. When we apply higher cut for counts, the flow direction became more definite. For this analysis we use data files where the two neighbouring energy values and elevation values are collapsed; and the azimuthal resolution is 45o, that is the solar wind azimuthal segmentation is also collapsed. Here we use day 2014.09.11. as illustration. On that day a solar wind shock reached the spacecraft at about ~10 UT. After the shock transition the energy of the solar wind became higher, and after ~12 UT the flow direction of the solar wind fluctuated, sometimes by 35o. On this day Rosetta flew at about 29.3-29.6 km from the nucleus. In the azimuth-elevation plots summed over "weighted energy" (as defined above) we were able to identify two flow directions

  13. Analysis of the Varicella-Zoster Virus IE62 N-Terminal Acidic Transactivating Domain and Its Interaction with the Human Mediator Complex▿

    OpenAIRE

    Yamamoto, Shinobu; Eletsky, Alexander; Szyperski, Thomas; Hay, John; Ruyechan, William T.

    2009-01-01

    The varicella-zoster virus major transactivator, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD). Our experiments revealed that the minimal IE62 TAD encompasses amino acids (aa) 19 to 67. We showed that the minimal TAD interacts with the human Mediator complex. Site-specific mutations revealed residues throughout the minimal TAD that are important for both activation and Mediator interaction. The TAD interacts directly with aa 402 to 590 of the MED25 subunit,...

  14. Roving UAV IED Interdiction System

    Science.gov (United States)

    2011-03-01

    UAVs (Raven, Wasp, and Puma) do not advertise any payload capability, the Tier I operators that Team Bravo contacted claimed small payload...www.ncca.navy.mil/services/inflation.cfm (accessed February 2011). Net Resources International. "Javelin Anti- Armour Missile." Army-Technology.com. 2011. http

  15. ~ILITARY ACA[)E~IES

    African Journals Online (AJOL)

    from World War II and managed quite well with an officers corps where ... management fields such as programme bud- getting, personnel .... tematic preparation in the art of warfare.' The famous ..... studies or strategic studies. Despite some.

  16. A Baculovirus immediate-early gene, ie1, promoter drives efficient expression of a transgene in both Drosophila melanogaster and Bombyx mori.

    Directory of Open Access Journals (Sweden)

    Mika Masumoto

    Full Text Available Many promoters have been used to drive expression of heterologous transgenes in insects. One major obstacle in the study of non-model insects is the dearth of useful promoters for analysis of gene function. Here, we investigated whether the promoter of the immediate-early gene, ie1, from the Bombyx mori nucleopolyhedrovirus (BmNPV could be used to drive efficient transgene expression in a wide variety of insects. We used a piggyBac-based vector with a 3xP3-DsRed transformation marker to generate a reporter construct; this construct was used to determine the expression patterns driven by the BmNPV ie1 promoter; we performed a detailed investigation of the promoter in transgene expression pattern in Drosophila melanogaster and in B. mori. Drosophila and Bombyx belong to different insect orders (Diptera and Lepidoptera, respectively; however, and to our surprise, ie1 promoter-driven expression was evident in several tissues (e.g., prothoracic gland, midgut, and tracheole in both insects. Furthermore, in both species, the ie1 promoter drove expression of the reporter gene from a relatively early embryonic stage, and strong ubiquitous ie1 promoter-driven expression continued throughout the larval, pupal, and adult stages by surface observation. Therefore, we suggest that the ie1 promoter can be used as an efficient expression driver in a diverse range of insect species.

  17. Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells

    Directory of Open Access Journals (Sweden)

    Dalle-Donne Isabella

    2008-10-01

    Full Text Available Abstract Background Recent studies demonstrate that recombinant adeno-associated virus (rAAV-based antigen loading of dendritic cells (DCs generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL responses against viral antigens. Methods We used the rAAV system to induce specific CTLs against CVM antigens for the development of cytomegalovirus HCMV gene therapy. As an extension of the versatility of the rAAV system, we incorporated immediate-early 1 (IE1, expressed in HCMV. Our rAAV vector induced a strong stimulation of CTLs directed against the HCMV antigen IE1. We then investigated the efficiency of the CTLs in killing IE1 targeted cells. Results A significant MHC Class I-restricted, anti-IE1-specific CTL killing was demonstrated against IE1 positive peripheral blood mononuclear cells (PBMC after one, in vitro, stimulation. Conclusion In summary, single PBMC stimulation with rAAV/IE1 pulsed DCs induces strong antigen specific-CTL generation. CTLs were capable to lyse low doses of peptides pulsed into target cells. These data suggest that AAV-based antigen loading of DCs is highly effective for generating human CTL responses against HCMV antigens.

  18. POLÍTICAS E INCENTIVOS AO EMPREENDEDORISMO EM INSTITUIÇÕES DE ENSINO SUPERIOR (IES - UMA NOVA ABORDAGEM PARA A GESTÃO EDUCACIONAL

    Directory of Open Access Journals (Sweden)

    Günther Lother Pertschy

    2003-05-01

    Full Text Available RESUMO
    Este artigo aborda as principais bases do empreendedorismo, as características preponderantes do empreendedor e a relação desses últimos com as instituições de ensino superior (IES. Advogamos aqui o empreendedorismo, como uma vantagem competitiva quando bem desenvolvido por meio de políticas e incentivos de amplo espectro e de fontes diversas. Discutimos aqui um rol de políticas e diferentes formas de incentivo ao empreendedorismo em IES. Esta análise nos permite concluir que o desenvolvimento e expansão das IES, hoje, dependem mais de uma atitude empreendedora, ou um movimento empreendedor de dentro para fora, lastreado em parcerias devidamente planejadas, na excelência ou qualidade de seus produtos/serviços e na visão do negócio educacional como sustentação da educação, do que na simples racionalização de seus custos operacionais. Por fim, mostramos que atitude empreendedora traz vantagens competitivas inigualáveis para as IES, especialmente para as chamadas "Faculdades Integradas e Isoladas", mais ágeis, com estruturas enxutas e menos custosas.
    Palavras-chave:empreendedor; empreendedorismo; empreendedorismo e IES; políticas e empreendedorismo; incentivo ao empreendedorismo

  19. Establishment of a sensitive time-resolved fluoroimmunoassay for detection of Bacillus thuringiensis Cry1Ie toxin based nanobody from a phage display library.

    Science.gov (United States)

    Xu, Chongxin; Liu, Xiaoqin; Zhang, Cunzheng; Zhang, Xiao; Zhong, Jianfeng; Liu, Yuan; Hu, Xiaodan; Lin, Manman; Liu, Xianjin

    2017-02-01

    Cry1Ie toxin was an insect-resistant protein used in genetically modified crops (GMC). In this study, a large human VH gene nanobodies phage displayed library was employed to select anti-Cry1Ie toxin antibody by affinity panning. After 5 rounds of panning, total 12 positive monoclonal phage particles were obtained. One of the identified positive phage nanobody was expressed in E.coli BL21 and the purified protein was indicated as a molecular mass of approximately 20 kDa by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Then a sensitive indirect competitive time-resolved fluoroimmunoassay (IC-TRFIA) was established for detection of Cry1Ie toxin by the purified protein. The working range of detection for Cry1Ie toxin standards in the IC-TRFIA were 0.08-6.44 ng mL -1 and the medium inhibition of control (IC 50 ) was 0.73 ng mL -1 . It showed a weak cross-reactivity with Cry1Ab toxin (at 5.6%), but did not recognize Cry1B, Cry1C, Cry1F, and Cry2A toxins (were <0.1%). The average recoveries of Cry1Ie toxin from respectively spiked in rice, corn and soil samples were in the range of 83.5%-96.6% and with a coefficient of variation (CV) among 2.0%-8.6%. These results showed the IC-TRFIA was promising for detection of Cry1Ie toxin in agricultural and environmental samples. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. A randomised clinical trial of comprehensive cardiac rehabilitation versus usual care for patients treated for infective endocarditis--the CopenHeartIE trial protocol

    DEFF Research Database (Denmark)

    Rasmussen, Trine Bernholdt; Zwisler, Ann-Dorthe; Sibilitz, Kirstine Lærum

    2012-01-01

    Infective endocarditis (IE) is among the most serious infectious diseases in the western world. Treatment requires lengthy hospitalisation, high-dosage antibiotic therapy and possible valve replacement surgery. Despite advances in treatment, the 1-year mortality remains at 20-40%. Studies indicate...

  1. MANIPULAREA UNUI EVENIMENT ȘI PARIURILE ARANJATE (art.2421 ȘI 2422 CP RM): INFRACȚIUNI DE CORUPȚIE?

    OpenAIRE

    Gheorghe RENIŢĂ

    2017-01-01

    În prezentul demers științific ne propunem să oferim răspuns la întrebarea cu care el se deschide: manipularea unui eveniment și pariurile aranjate (art.2421 și 2422 din Codul penal al Republicii Moldova (CP RM)): infracțiuni de corupție? Altfel spus, este oare îndreptățită optica de a raporta infracțiunile de manipulare a unui eveniment și de pariuri aranjate la grupul celor de corupție? Punctul de pornire pentru elaborarea acestei investigații l-a constituit Proiectul de Lege nr.268/2016, c...

  2. Uranium from German nuclear projects of the 1940ies. A nuclear forensic study; Uran aus deutschen Nuklearprojekten der 1940er Jahre. Eine nuklearforensische Untersuchung

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, Klaus; Wallenius, Maria; Luetzenkirchen, Klaus [European Comission, Joint Research Centre (JRC), Karlsruhe (Germany). Inst. for Transuranium Elements (ITU); and others

    2015-11-02

    In the 1940ies in Germany studies using uranium in different geometries were started. Using the isotope ration Th-230/U-234 it was possible to determine the materials used in 1949-1943.The geographic origin was determined from trace amounts of rare earths. The uranium used in German research projects came from Czech uranium mines. Traces of U-236 and Pu-236 were found corresponding to the normal occurrence. This fact indicates that no significant neutron irradiation has occurred.

  3. Does the MRAP Meet the US Army’s Needs as the Primary Method of Protecting Troops from the IED Threat?

    Science.gov (United States)

    2009-06-12

    SGT Spencer patrols over a two weeks period. Two IED attacks killed six Afghans and wounded two Canadian soldiers. The route clearance team lives...minefield would be cleared using flail tanks, mine-clearing rollers, mine ploughs or other devices. The Cold War, with its defensive posture in...May 2008, eleven US troops were killed by IEDs, compared with 92 in May 2007. The article states several reasons for this drop. The first is the

  4. Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

    Science.gov (United States)

    Datsenko, Kirill A.; Jackson, Ryan N.; Wiedenheft, Blake; Severinov, Konstantin; Brouns, Stan J. J.

    2013-01-01

    Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts are processed into small RNAs that guide CRISPR-associated (Cas) proteins to invading nucleic acids by complementary base pairing. However, to avoid autoimmunity it is essential that these RNA-guides exclusively target invading DNA and not complementary DNA sequences (i.e., self-sequences) located in the host's own CRISPR locus. Previous work on the Type III-A CRISPR system from Staphylococcus epidermidis has demonstrated that a portion of the CRISPR RNA-guide sequence is involved in self versus non-self discrimination. This self-avoidance mechanism relies on sensing base pairing between the RNA-guide and sequences flanking the target DNA. To determine if the RNA-guide participates in self versus non-self discrimination in the Type I-E system from Escherichia coli we altered base pairing potential between the RNA-guide and the flanks of DNA targets. Here we demonstrate that Type I-E systems discriminate self from non-self through a base pairing-independent mechanism that strictly relies on the recognition of four unchangeable PAM sequences. In addition, this work reveals that the first base pair between the guide RNA and the PAM nucleotide immediately flanking the target sequence can be disrupted without affecting the interference phenotype. Remarkably, this indicates that base pairing at this position is not involved in foreign DNA recognition. Results in this paper reveal that the Type I-E mechanism of avoiding self sequences and preventing autoimmunity is fundamentally different from that employed by Type III-A systems. We propose the exclusive targeting of PAM-flanked sequences to be termed a target versus non-target discrimination mechanism. PMID:24039596

  5. The Soviet State Social Policy in the Sphere of Development of the Material Culture of the Southern Russian Peasants in the 1920-ies

    Directory of Open Access Journals (Sweden)

    Susanna D. Bagdasaryan

    2014-10-01

    Full Text Available This article discusses the problems of formation of the Soviet state social policy transformations in material culture of the southern Russian peasants in the 1920-ies. The necessity of studying the Soviet state social policy in Russia in the period of 1920-ies the historical aspect is determined by several factors. First, in the study of Russian history of the XX century, one of the main directions of national historiography was and remains the study of social problems at various stages of its development. In this regard, relevant is the consideration of the main challenges for social development at country and regional level. Secondly, in the formation of a new concept of social development of the country increases the need to adequate understanding of the role and importance of the Soviet state in the modernization of Russian society. One of the fundamental principles of state social policy is the principle of state responsibility for creating the conditions necessary for the development of society and the individual. In this regard, special scientific and practical interest becomes the problem of the essence of social policy in different historical periods, especially in the 1920-ies the history of the Soviet state, when it formed the Soviet system. In the analysed time clearly showed different approaches to solving social problems: in the framework of the state ideology and assumptions in Economics elements of private property (1921-1929.

  6. Study of aac(6'Ie-aph(2″Ia Gene in Clinical Strain of Enterococci and Identification of High-Level Gentamicin Resistante Enterococci

    Directory of Open Access Journals (Sweden)

    N. Dadfarma

    2010-10-01

    Full Text Available Introduction & Objective: Enterococci have emerged as the leading nosocomial pathogens. In addition to natural resistance to many agents, enterococci have also developed plasmid- and transposon-mediated resistance to high concentrations of aminoglycosides. High-level gentamicin resistance (HLGR of enterococci results in the failure of drug synergism with an aminoglycoside plus cell-wall-active agents. HLGR (MIC=500μg/ml strains is usually due to the presence of the aac(6'Ie-aph(2″Ia gene . Materials & Methods: In the present experimental study 142 enterococci were isolated from the patients’ species. Identification was done by using standard methods and antimicrobial susceptibility test was performed by disc diffusion technique. MIC of Gentamicin was determined by a broth micro dilution method (NCCLS. PCR was performed to detect the aac(6'Ie-aph(2″Ia gene .Presence of the gene aac(6'-Ie-aph(2″-Ia was confirmed by digest with Sca1 enzyme. A PCR product was sequenced and BLAST analyzed at the NCBI database to be confirmed. Results: 62(43.7% out of the 142 isolates, were found to exhibit HLGR phenotype. MIC ranging from 512 to >1024 μg/ml in 55 HLGR isolates. All resistant isolates except one, were found to harbor the aac(6'Ie-aph(2″Ia gene. In our strain collection, 42% of E. faecalis and 44% of E. faecium were HLGR. In the HLGR isolates the prevalence of resistance to other antibiotics and Multi Drug Resistance (MDR was higher than non–HLGR.This prevalence in E.faecium was higher than E.faecalis. The sequence was compared with a published sequence and confirmed. Conclusion: Our results indicate that high prevalence of MDR and HLGR enterococcal colonization is an important problem in our medical centers.Spread of the aac(6'-Ie-aph(2″-Ia gene was responsible for HLGR among enterococci isolated from the patients in Tehran. (Sci J Hamadan Univ Med Sci 2010;17(3:25-32

  7. The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products.

    Science.gov (United States)

    Rattay, Stephanie; Trilling, Mirko; Megger, Dominik A; Sitek, Barbara; Meyer, Helmut E; Hengel, Hartmut; Le-Trilling, Vu Thuy Khanh

    2015-08-01

    Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major immediate early promoter/enhancer (MIEP) and requires differential splicing. Based on complete loss of genome replication of an MCMV mutant carrying a deletion of the ie3-specific exon 5, the multifunctional IE3 protein (611 amino acids; pIE611) is considered essential for viral replication. Our analysis of ie3 transcription resulted in the identification of novel ie3 isoforms derived from alternatively spliced ie3 transcripts. Construction of an IE3-hemagglutinin (IE3-HA) virus by insertion of an in-frame HA epitope sequence allowed detection of the IE3 isoforms in infected cells, verifying that the newly identified transcripts code for proteins. This prompted the construction of an MCMV mutant lacking ie611 but retaining the coding capacity for the newly identified isoforms ie453 and ie310. Using Δie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611 for viral replication. To determine the role of pIE611 for viral gene expression during MCMV infection in an unbiased global approach, we used label-free quantitative mass spectrometry to delineate pIE611-dependent changes of the MCMV proteome. Interestingly, further analysis revealed transcriptional as well as posttranscriptional regulation of MCMV gene products by pIE611. Cytomegaloviruses are pathogenic betaherpesviruses persisting in a lifelong latency from which reactivation can occur under conditions of immunosuppression, immunoimmaturity, or inflammation. The switch from latency to reactivation requires expression of immediate early genes. Therefore, understanding of immediate early gene regulation might add insights into viral pathogenesis. The mouse cytomegalovirus (MCMV) immediate early 3 protein (611 amino acids; pIE611) is considered essential for viral replication. The identification of novel protein isoforms derived from alternatively spliced ie3 transcripts prompted

  8. Alinhamento das atividades de pesquisa científica e tecnológica realizadas pelas IES federais de Minas Gerais e as diretrizes da – PITCE

    Directory of Open Access Journals (Sweden)

    Karina Pereira Vieira

    2011-11-01

    Full Text Available It is argued in this paper the possible alignment between scientific activities and technological research carried out by universities and the guidelines of public policies on science and technology in Brazil. As a way of delimiting the field of analysis, without compromising the scope of this paper, we restricted our focus on the federal public universities in Minas Gerais State and we checked the possible convergence with the Industrial Policy and Foreign Trade (PITCE. More than that, it is argued as essential the function of universities as generators of knowledge within an innovation system and a closer university-industry-state relation should be pursued as proposed by the ‘Triple helix’.Discute-se, nesse trabalho, o possível alinhamento entre atividades de pesquisa científica e tecnológica realizadas por instituições de ensino superior – IES e as diretrizes das políticas públicas de ciência e tecnologia do país. Como forma de delimitar o campo de análise, sem comprometer o escopo do trabalho, optou-se pela avaliação das áreas de pesquisa das IES federais mineiras e sua convergência com a Política Industrial e de Comércio Exterior – PITCE. Mais do que isso, defende-se como essencial a função das IES enquanto geradoras de conhecimento dentro de um Sistema de Inovação, bem como um estreitamento das relações universidade-Estado-empresa como propõe a “hélice tríplice”.

  9. Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia

    Science.gov (United States)

    Smith, Clyde A.; Toth, Marta; Bhattacharya, Monolekha; Frase, Hilary; Vakulenko, Sergei B.

    2014-01-01

    The bifunctional acetyltransferase(6′)-Ie-phosphotransfer­ase(2′′)-Ia [AAC(6′)-Ie-APH(2′′)-Ia] is the most important aminoglycoside-resistance enzyme in Gram-positive bacteria, conferring resistance to almost all known aminoglycoside antibiotics in clinical use. Owing to its importance, this enzyme has been the focus of intensive research since its isolation in the mid-1980s but, despite much effort, structural details of AAC(6′)-Ie-APH(2′′)-Ia have remained elusive. The structure of the Mg2GDP complex of the APH(2′′)-Ia domain of the bifunctional enzyme has now been determined at 2.3 Å resolution. The structure of APH(2′′)-Ia is reminiscent of the structures of other aminoglycoside phosphotransferases, having a two-domain architecture with the nucleotide-binding site located at the junction of the two domains. Unlike the previously characterized APH(2′′)-IIa and APH(2′′)-IVa enzymes, which are capable of utilizing both ATP and GTP as the phosphate donors, APH(2′′)-Ia uses GTP exclusively in the phosphorylation of the aminoglycoside antibiotics, and in this regard closely resembles the GTP-dependent APH(2′′)-IIIa enzyme. In APH(2′′)-Ia this GTP selectivity is governed by the presence of a ‘gatekeeper’ residue, Tyr100, the side chain of which projects into the active site and effectively blocks access to the adenine-binding template. Mutation of this tyrosine residue to a less bulky phenylalanine provides better access for ATP to the NTP-binding template and converts APH(2′′)-Ia into a dual-specificity enzyme. PMID:24914967

  10. High-Throughput Characterization of Cascade type I-E CRISPR Guide Efficacy Reveals Unexpected PAM Diversity and Target Sequence Preferences.

    Science.gov (United States)

    Fu, Becky Xu Hua; Wainberg, Michael; Kundaje, Anshul; Fire, Andrew Z

    2017-08-01

    Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are transcribed and processed to produce small CRISPR RNAs (crRNAs), with degradation of invading genetic material directed by a combination of complementarity between RNA and DNA and in some cases recognition of adjacent motifs called PAMs (Protospacer Adjacent Motifs). Here we describe a general, high-throughput procedure to test the efficacy of thousands of targets, applying this to the Escherichia coli type I-E Cascade (CRISPR-associated complex for antiviral defense) system. These studies were followed with reciprocal experiments in which the consequence of CRISPR activity was survival in the presence of a lytic phage. From the combined analysis of the Cascade system, we found that (i) type I-E Cascade PAM recognition is more expansive than previously reported, with at least 22 distinct PAMs, with many of the noncanonical PAMs having CRISPR-interference abilities similar to the canonical PAMs; (ii) PAM positioning appears precise, with no evidence for tolerance to PAM slippage in interference; and (iii) while increased guanine-cytosine (GC) content in the spacer is associated with higher CRISPR-interference efficiency, high GC content (>62.5%) decreases CRISPR-interference efficiency. Our findings provide a comprehensive functional profile of Cascade type I-E interference requirements and a method to assay spacer efficacy that can be applied to other CRISPR-Cas systems. Copyright © 2017 by the Genetics Society of America.

  11. La cultura de la mediación: impacto de un programa preventivo de sensibilización, en IES de la Región de Murcia

    OpenAIRE

    Ortuño Muñoz, Emilia de los Ángeles

    2014-01-01

    El presente trabajo se estructura de la siguiente forma: OBJETIVO GENERAL El objetivo general de la investigación era el de indagar sobre la percepción de la conflictividad escolar y su afrontamiento, en el entorno cercano para posteriormente, medir el impacto de un programa preventivo de sensibilización en IES de la Región de Murcia. El esquema del programa de sensibilización estaba basado en todos aquellos aspectos que se aglutinan en la denominada “Cultura de la Mediación”, enten...

  12. Leemos y Aprendemos para mejorar la comprensión de textos en los estudiantes de I.E. Lord Byron, La Molina 2016

    OpenAIRE

    Geremias Casasola, Evelyn Melissa

    2017-01-01

    La investigación presentó como propósito determinar la influencia del Programa Leemos y Aprendemos para mejorar la comprensión de textos en los estudiantes de I.E. Lord Byron, La Molina 2016. Dicho estudio empleo la metodología aplicada de diseño pre experimental, longitudinal. La población estuvo constituida por los estudiantes de la I. E. Lord Byron, La Molina 2016. Se utilizó el muestreo no probabilístico de carácter intencionado. Para construir, validar y demostrar la co...

  13. Factores predominantes que determinan el clima organizacional de la I.E. José Abelardo Quiñones del distrito de Mala-Cañete

    OpenAIRE

    Urbina Díaz, Lenny Esther

    2016-01-01

    La tesis tiene por objetivo identificar los factores que determinan el clima organizacional de la I.E. José Abelardo Quiñones de Mala, Cañete. Para ello, se ha estudiado el marco teórico sobre la variable de estudio: el clima organizacional. En la investigación se utilizó la metodología de tipo cuantitativo, basada en el paradigma positivista. Además se aplicó un cuestionario adaptado a la realidad del estudio. Las encuestas aplicadas al personal de la institución fueron analizadas mediante e...

  14. A comparative evaluation of IONSIV reg-sign IE-911 and chabazite zeolite for the removal of radiostrontium and cesium from wastewater

    International Nuclear Information System (INIS)

    Bostick, D.T.; DePaoli, S.M.; Guo, B.

    1998-01-01

    Natural chabazite zeolite was selected as the baseline treatment technology for the removal of fission products, namely 90 Sr and 137 Cs, from near-neutral-pH process wastewater and groundwater. The sorbent IONSIV reg-sign IE-911, a crystalline silicotitanate manufactured by UOP, was recently tested in this capacity and found to compare extremely well against the baseline material. This paper presents and compares the results of similar batch and column tests performed using both materials, and summarizes the physical and chemical characteristics of the sorbents

  15. RECONOCIMIENTO DEL CUERPO DESDE LA EDUCACIÓN EN SEXUALIDAD EN LOS ESTUDIANTES DE SÉPTIMO DEL COLEGIO VILLEMAR EL CARMEN IED

    OpenAIRE

    Luz Adriana Prieto Cárdenas

    2016-01-01

    Este trabajo es el resultado de la práctica de intervención pedagógica e investigativa realizada en el año 2014, en el Colegio Villemar el Carmen ied, con los estudiantes de 705, jornada mañana. El problema investigativo se construyó a partir de los intereses e inquietudes que presentó el grupo de estudiantes respecto a su cuerpo y su sexualidad. El objetivo principal que guio esta investigación fue analizar la incidencia de la educación en sexualidad en el reconocimiento del cuerpo de los es...

  16. IEEE Std 383-1974: IEEE standard for type test of Class IE electric cables, field splices, and connections for nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This standard provides direction for establishing type tests which may be used in qualifying Class 1E electric cables, field splices, and other connections for service in nuclear power generating stations. General guidelines for qualifications are given in IEEE Std 323-1974, Standard for Qualifying Class IE Electric Equipment for Nuclear Power Generating Stations. Categories of cables covered are those used for power control and instrumentation services. Though intended primarily to pertain to cable for field installation, this guide may also be used for the qualification of internal wiring of manufactured devices. This guide does not cover cables for service within the reactor vessel

  17. Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori

    OpenAIRE

    Iļjenko, Ivonna

    2015-01-01

    Maģistra darba nosaukums ir „Franšīzes devēju un franšīzes ņēmēju konfliktu izraisošie faktori”. Maģistra darba mērķis ir identificēt būtiskākos konfliktu izraisošos faktorus franšīzes devēju un franšīzes ņēmēju attiecībās, raksturot franšīzes praktisko pielietojumu un izstrādāt priekšlikumus franšīzes popularizēšanai un konfliktu novēršanai franšīzes attiecībās Latvijā. Darba pirmajā nodaļā raksturota franšīzes būtība, tās priekšrocības un trūkumi, konflikta process, konfliktu izraisošie...

  18. DEFINIŢIA LEGISLATIVĂ A NOŢIUNII „PERSOANĂ CU FUNCŢIE DE DEMNITATE PUBLICĂ”: ANALIZA EVOLUŢIEI

    Directory of Open Access Journals (Sweden)

    Sergiu BRÎNZA

    2017-01-01

    Full Text Available Scopul investigaţiei de faţă rezidă în analiza evoluţiei pe care a parcurs-o definiţia legislativă a noţiunii „persoană cu funcţie de răspundere”. Se relevă că dispoziţia de la alin.(3 art.123 CP RM a fost supusă unor amendamente prin Legea nr.318/2013 şi prin Legea nr.152/2016. Se stabileşte că în rezultatul acestor amendamente: din respectiva dispoziţie a fost exclus textul „consilierul local; deputatul în Adunarea Populară a Găgăuziei;”; în dispoziţia alin.(3 art.123 CP RM, cu­vin­tele „în condiţiile legii” au fost substituite cu cuvintele „altă persoană cu funcţie de demnitate publică stabilită prin lege”. Se demonstrează că consilierul local şi deputatul în Adunarea Populară a Găgăuziei nu sunt persoane cu funcţii de demnitate publică nici în sensul Legii nr.199/2010, nici în sensul alin.(3 art.123 CP RM. Se ajunge la concluzia că, în rezultatul adoptării Legii nr.152/2016, definiţia noţiunii „persoană cu funcţie de demnitate publică” s-a transformat din definiţie exhaustivă în definiţie exemplificativă. Se argumentează că sintagma „altă persoană cu funcţie de demnitate publică stabilită prin lege” din alin.(3 art.123 CP RM arată că această normă constituie o normă divizată de referire. Se explică de ce este falsă impresia că ar exista persoane cu funcţie de demnitate publică, care nu sunt specificate în anexa la Legeanr.199/2010 şi cărora nu li se aplică prevederile acestei legi. Se conchide că alin.(3 art.123 CP RM, complinit de anexa la Legeanr.199/2010, sunt singurele norme care stabilesc conţinutul noţiunii „persoană cu funcţie de demnitate publică”. Alte norme pot doar să dezvolte prevederile acestora, fără a le lărgi sfera de incidenţă. Printre astfel de norme dezvoltătoare se numără: alin.(3 art.17 din Codul electoral; alin.(51 art.42 al Legii cu privire la energetică; art.131 al Legii privind Comisia Na

  19. Rare Earth Element Concentrations and Fractionation Patterns Along Groundwater Flow Paths in Two Different Aquifer Types (i.e., Sand vs. Carbonate)

    Science.gov (United States)

    Johannesson, K. H.; Tang, J.

    2003-12-01

    Groundwater samples were collected in two different types of aquifer (i.e., Carrizo Sand Aquifer, Texas and Upper Floridan carbonate Aquifer, west-central Florida) to study the concentrations, fractionation, and speciation of rare earth elements (REE) along groundwater flow paths in each aquifer. Major solutes and dissolved organic carbon (DOC) were also measured in these groundwaters. The Carrizo Sand aquifer was sampled in October 2002 and June 2003, whereas, to date, we have only sampled the Floridan once (i.e., June 2003). The data reveal no significant seasonal differences in major solute and REE concentrations for the Carrizo. In Carrizo sand aquifer, groundwaters from relatively shallow wells (i.e., less than 167 m) in the recharge zone are chiefly Ca-Na-HCO3-Cl type waters. With flow down-gradient the groundwaters shift composition to the Na-HCO3 waters. pH and alkalinity initially decrease with flow away from the recharge zone before increasing again down-gradient. DOC is generally low (0.65 mg/L) along the flow path. REE concentrations are highest in groundwaters from the recharge zone (Nd 40.5 pmol/kg), and decrease substantially with flow down-gradient reaching relatively low and stable values (Nd 4.1-8.6 pmol/kg) roughly 10 km from the recharge zone. Generally, Carrizo groundwaters exhibit HREE-enriched shale-normalized patterns. The HREE enrichments are especially strong for waters from the recharge zone [(Yb/Nd)SN =1.7-5.6], whereas down-gradient (deep) groundwaters have flatter patterns [(Yb/Nd)SN =0.7-2.5]. All groundwaters have slightly positive Eu anomalies (Eu/Eu* 0.09-0.14) and negative Ce anomalies (Ce/Ce* -0.85 - -0.07). In the Upper Floridan Aquifer, Ca, Mg, SO4, and Cl concentrations generally increase along groundwater flow path, whereas pH and alkalinity generally decrease. DOC is higher (0.64 - 2.29 mg/L) than in the Carrizo and initially increases along the flow path and then decreases down-gradient. LREE (Nd) concentrations generally

  20. Governança corporativa, responsabilidade social corporativa: a visão de atores de uma instituição de ensino superior – IES federal

    Directory of Open Access Journals (Sweden)

    Maria da Graça Saraiva Nogueira

    2012-12-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2012v5n3p222   Este trabalho busca investigar, junto a uma IES pública, em que aspectos a sua gestão aproxima-se dos elementos componentes da governança corporativa e suas relações com a responsabilidade social da instituição. A metodologia foi uma pesquisa descritiva, de abordagem qualitativa, a coleta de informações foi a de entrevista semi-estruturada, com atores da organização. O registro foi feito através de gravação de áudio e transcrição literal, com a devida leitura e autorização dos entrevistados para o uso de seu conteúdo no artigo aqui apresentado. Para análise dos dados foi utilizada análise de conteúdo. Os principais resultados sobre a GC e sobre a legitimidade, confiabilidade e credibilidade estão presentes na instituição. De acordo com as falas do entrevistado, percebe-se a integração na gestão, nos processos decisórios e no comportamento estratégico que prima pela qualidade e excelência do ensino público e gratuito. Os resultados em relação à RSC identificaram que a IES estudada não apresenta uma política institucional formalizada, voltada para a comunidade. Mesmo assim, a percepção é a de que a IES está caminhando nessa direção e acredita que as instituições que não reagirem de forma proativa em relação às questões sociais, serão cobradas pela própria sociedade.

  1. A síndrome de Burnout em estudantes de ciências contábeis de IES Privadas: pesquisa na cidade de São Paulo

    Directory of Open Access Journals (Sweden)

    Ivam Ricardo Peleias

    2017-01-01

    Full Text Available O objetivo do estudo é identificar a prevalência e os fatores sociodemográficos, laborais e acadêmicos associados a Síndrome de Burnout em ultimoanistas de Ciências Contábeis. Burnout é o resultado do stress crônico e constitui-se em alterações nas dimensões (a Exaustão Emocional, (b Descrença e (c Eficácia Profissional. É uma pesquisa empírico-analítica junto a uma amostra não probabilística de 419 alunos do período noturno de sete IES privadas da cidade de São Paulo. Como instrumentos de pesquisa foram usados o MBI-SS e um questionário para as variáveis sociodemográficas, laborais e acadêmicas. Nas três dimensões foram constatadas diferenças significativas entre os alunos, agrupados em cinco categorias de trabalho. A aferição em três dimensões indicou 46,3% dos alunos com alteração na Exaustão Emocional, 11,2% na Descrença e 31,3% na Eficácia Profissional. Foram encontrados três grupos de alunos com alterações, relativas às dimensões as quais estão expostos. Estão descritos os resultados obtidos em dois grupos, expostos a duas ou mais dimensões causadoras de Burnout. O grupo 2 revelou alterações na Exaustão Emocional e em alguma outra dimensão, o grupo 3 nas três dimensões. Os alunos de uma IES revelaram nos três grupos maiores chances de exposição a Burnout. O mesmo ocorreu para os sujeitos do grupo 3 de outras IES. Parte dos sujeitos manifestou a sensação de que não estarem capacitados aumenta as chances de exposição a Burnout.

  2. A educação superior e a perspectiva agroecológica: avanços e limites dos Núcleos de Agroecologia das IES no Brasil

    Directory of Open Access Journals (Sweden)

    Luis Mauro Santos Silva

    2017-04-01

    Full Text Available O presente artigo trás reflexões sobre a importância dos Núcleos de Estudos Agroecológicos (NEAs criados via políticas do Governo Federal. No contexto analisado, os NEAs se apoiam, invariavelmente, nas lógicas familiares de produção como protagonistas de um novo formato de ensino, pesquisa e extensão. Baseado em uma revisão documental e teórica, observou-se que a proposta de criação dos núcleos trás como inovação, princípios para a construção coletiva de conhecimentos agroecológicos, ou seja, socialmente elaborados e considerando as múltiplas dimensões do desenvolvimento regional. Para a criação desses NEAS em todo o território nacional, fez-se necessário o envolvimento ativo dos mais diversos atores sociais e as IES, possibilitando uma nova perspectiva epistemológica, onde o saber popular ganha em reconhecimento e contribui na busca de resoluções de demandas sociais locais, sejam elas produtivas, educacionais, ecológicas, tecnológicas etc. Vale salientar que por meio desses ambientes coletivos, novos cenários Institucionais surgiram. A própria criação de novas IES, especialmente nas regiões mais distantes dos grandes centros urbanos, mostrou uma maior sensibilidade na incorporação de demandas locais da sociedade civil. E, mesmo com limites bem marcados dessa iniciativa pública, em menos de uma década essa ação vem proporcionando uma efetiva articulação regional e nacional de novos formatos de IES, tornando os NEAs referências no debate em torno de temas estratégicos ligados a perspectiva agroecológica.

  3. Some aspects of the distribution and dynamics of the benthic macroinvertebrate groups from Nimăieşti valley river

    Directory of Open Access Journals (Sweden)

    CUPŞA Diana

    2005-09-01

    Full Text Available In the Nimăieşti Valley river we found in a number of four sample sites a community of benthic macroinvertebrates represented by Oligochaeta, Ephemeroptera larva, Trichoptera larva, Chironomida larva and Hidracarina species. The communities structure vary depending on season and the sampling site acording to the water quality and trophic condition of the substrate. The greatest diversity was recorded during the summer months (may-august and comparing the sample sites, we found that the first three sampling sites are very similar from the point of view of the macroinvertebrate community, but the fourth sampling site the community is different because the river pases through the town of Beiuş and as a consequence the water quality is lower that at the other three sample sites.

  4. Governança corporativa, responsabilidade social corporativa: a visão de atores de uma instituição de ensino superior – IES federal

    OpenAIRE

    Maria da Graça Saraiva Nogueira; Tania Elisa Morales Garcia; Maria da Graça Gomes Ramos

    2012-01-01

    http://dx.doi.org/10.5007/1983-4535.2012v5n3p222   Este trabalho busca investigar, junto a uma IES pública, em que aspectos a sua gestão aproxima-se dos elementos componentes da governança corporativa e suas relações com a responsabilidade social da instituição. A metodologia foi uma pesquisa descritiva, de abordagem qualitativa, a coleta de informações foi a de entrevista semi-estruturada, com atores da organização. O registro foi feito através de gravação de áudio e transcrição lite...

  5. DILEMA DIFERENŢIERII RĂSPUNDERII PENALE PENTRU RELELE TRATAMENTE COMISE DE O PERSOANĂ CU FUNCŢIE DE RĂSPUNDERE

    Directory of Open Access Journals (Sweden)

    Daniela URSU

    2017-01-01

    Full Text Available Deoarece unele autorităţi (ca, de exemplu, poliţistul sunt, potrivit literei legii (art.123 alin.(1 şi alin.(2 CP RM, atât persoane publice, cât şi persoane cu funcţie de răspundere, în contextul relelor tratamente incriminate la art.1661 CP RM, unii subiecţi de aplicare în concret a legii penale recunosc poliţistului calitatea de persoană cu funcţie de răspundere, motiv din care reţin circumstanţa agravantă în dependenţă de faptă, prevăzută fie la lit.e alin.(2, fie la lit.e alin.(4 art.1661 CP RM, iar alţii îi reţin calitatea de persoană publică, încadrându-i faptele în acord cu variantele-tip ale infrac­ţiu­nilor de tortură, tratament inuman sau degradant. Pornind de la câteva hotărâri din practica judiciară naţională, pre­zentul studiu îşi propune să ofere răspuns la următoarea întrebare: Care este cea mai potrivită soluţie de calificare în ipo­teza comiterii infracţiunilor de tortură, tratament inuman sau degradant de către autorităţi care deţin dubla calitate: atât de persoană publică, cât şi de persoană cu funcţie de răspundere?THE DIFFERENTIATION DILEMMA OF CRIMINAL LIABILITY REGARDING THE ILL-TREATMENT COMMITTED BY A PERSON WITH PUBLIC RESPONSIBILITIESBecause some authorities, like the policeman, are according to the law (Article 123 para.(1 and para.(2 of the Penal Code of Moldova, both public persons and persons holding responsible positions, in the context of maltreatment incri­minated by the article 1661 of the Penal Code of Moldova, some subjects invested with the power to apply the criminal law treat the police officials as persons holding a responsible positions, the reason why the aggravating circumstance, depending on the offense, is either letter e para.(2, either – letter e para.(4 article 1661 of the Penal Code of Moldova. While others treat them as public persons, stating their crimes as torture, inhuman or degrading treatment. Starting from several

  6. Reliability, sensitivity and validity of the assistant referee intermittent endurance test (ARIET) - a modified Yo-Yo IE2 test for elite soccer assistant referees

    DEFF Research Database (Denmark)

    Castagna, Carlo; Bendiksen, Mads; Impellizzeri, Franco M

    2012-01-01

    We examined the reliability and validity of the assistant referee intermittent endurance test (ARIET), a modified Yo-Yo IE2 test including shuttles of sideways running. The ARIET was carried out on 198 Italian (Serie A-B, Lega-Pro and National Level) and 47 Danish elite soccer assistant referees....... Reproducibility was tested for 41 assistant referees on four occasions each separated by one week. The ARIET intraclass correlation coefficients and typical error of measurement ranged from 0.96 to 0.99 and 3.1 to 5.7%, respectively. ARIET performance for Serie A and B was 23 and 25% greater than in Lega-Pro (P...... ARIET performance was significantly correlated with VO(2max) (r = 0.78, P ARIET (r = - 0.81, P

  7. Concurrent IMRT and weekly cisplatin followed by GDP chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell lymphoma.

    Science.gov (United States)

    Ke, Q-H; Zhou, S-Q; Du, W; Liang, G; Lei, Y; Luo, F

    2014-12-12

    On the basis of the benefits of frontline radiation in early-stage, extranodal natural killer (NK)/T-cell lymphoma (ENKTL), we conducted the trial of concurrent chemoradiotherapy (CCRT) followed by three cycles of gemcitabine, dexamethasone and cisplatin (GDP). Thirty-two patients with newly diagnosed, stage IE to IIE, nasal ENKTL received CCRT (that is, all patients received intensity-modulated radiotherapy 56 Gy and cisplatin 30 mg/m(2) weekly, 3-5 weeks). Three cycles of GDP (gemcitabine 1000 mg/m(2) intravenously (i.v.) on days 1 and 8, dexamethasone 40 mg orally on days 1-4 and cisplatin 75 mg/m(2) i.v. on day 1 (GDP), every 21 days as an outpatient were scheduled after CCRT. All patients completed CCRT, which resulted in 100% response that included 24 complete responses (CRs) and eight partial responses. The CR rate after CCRT was 75.0% (that is, 24 of 32 responses). Twenty-eight of the 32 patients completed the planned three cycles of GDP, whereas four patients did not because they withdrew (n = 1) or because they had an infection (n = 3). The overall response rate and the CR rate were 90.6% (that is, 29 of 32 responses) and 84.4% (that is, 27 of 32 responses), respectively. Only two patient experienced grade 3 toxicity during CCRT (nausea), whereas 13 of the 30 patients experienced grade 4 neutropenia. The estimated 3-year overall survival and progression-free rates were 87.50% and 84.38%, respectively. In conclusion, CCRT followed by GDP chemotherapy can be a feasible and effective treatment strategy for stage IE to IIE nasal ENKTL.

  8. MANIPULAREA UNUI EVENIMENT ȘI PARIURILE ARANJATE (art.2421 ȘI 2422 CP RM: INFRACȚIUNI DE CORUPȚIE?

    Directory of Open Access Journals (Sweden)

    Gheorghe RENIŢĂ

    2017-07-01

    Full Text Available În prezentul demers științific ne propunem să oferim răspuns la întrebarea cu care el se deschide: manipularea unui eveniment și pariurile aranjate (art.2421 și 2422 din Codul penal al Republicii Moldova (CP RM: infracțiuni de corupție? Altfel spus, este oare îndreptățită optica de a raporta infracțiunile de manipulare a unui eveniment și de pariuri aranjate la grupul celor de corupție? Punctul de pornire pentru elaborarea acestei investigații l-a constituit Proiectul de Lege nr.268/2016, care, inter alia, urmărește includerea art.2421 și 2422 CP RM printre infracțiunile de corupție. În acest sens, se constată că fapta exprimată în încurajarea, influenţarea sau instruirea unui participant la un eveniment sportiv sau la un eveniment de pariat să întreprindă acţiuni care ar produce un efect viciat asupra evenimentului respectiv, cu scopul de a obţine bunuri, servicii, privilegii sau avantaje sub orice formă, care nu i se cuvin, pentru sine sau pentru o altă persoană (art.2421 CP RM, precum și fapta de pariere pe un eveniment sportiv sau pe un alt eveniment de pariat, fie în informarea altor persoane despre existenţa unei înţelegeri în privinţa trucării acelui eveniment în intenţia de a le determina să participe la pariul respectiv, săvârşită de către o persoană care cunoaşte cu certitudine despre existenţa unei înţelegeri privind trucarea acelui eveniment (art.2422 CP RM, nu au cum să se plieze normelor care instituie răspunderea penală pentru coruperea pasivă (art.324 CP RM, coruperea activă (art.335 CP RM, traficul de influență (art.326 CP RM, luarea de mită (art.333 CP RM sau darea de mită (art.334 CP RM. Or, aceste prevederi incriminatoare au raze diferite de acțiune. Se relevă că pentru a atribui o infracțiune sau alta la categoria celor de corupție este ineluctabil ca aceasta să corespundă trăsăturilor definitorii ale corupției, și anume: să afecteze exercitarea

  9. A QUALIDADE DO ATENDIMENTO AO CLIENTE EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR – IES: UM ESTUDO DE CASO

    Directory of Open Access Journals (Sweden)

    Sylmara Teixeira Martins

    2015-06-01

    Full Text Available Com o avanço da tecnologia e o expressivo aumento da concorrência, as organizações têm buscado cada vez mais encontrar maneiras de oferecer, não só produtos e serviços, como, principalmente, um atendimento de qualidade. Assim, a qualidade no atendimento ao cliente é algo essencial para as organizações que buscam obter bons resultados através da satisfação e da fidelização de seus clientes/consumidores. Apresente pesquisa caracterizou-se como uma pesquisa de campo, tendo como objetivo avaliar o nível da satisfação dos clientes de uma Instituição de Ensino Superior localizada no Município de Quixadá-CE. A coleta de dados foi realizada, utilizando-se de um questionário de carácter quanti-qualitativo. A apresentação dos resultados foi feita por meio da utilização de gráficos que possibilitaram uma melhor descrição e compreensão dos resultados obtidos. Assim, pôde-se concluir que a maioria dos clientes da IES pesquisada estão insatisfeitos com a qualidade do atendimento oferecido pela referida instituição e que os fatores que levaram a essa falta de qualidade são oriundos da ausência de capacitação e de motivação dos funcionários da IES. A pesquisa também mostrou que este problema de qualidade no atendimento poderia ser solucionado coma fixação de uma política de motivação, envolvendo ações como: a implantação de plano de cargos e salários, a disponibilização de benefícios e a oferta de treinamento para os funcionários, que seriam as melhores maneiras para solucionar esse problema com a qualidade do atendimento.

  10. PROCEDURA DE EXAMINARE A CERERII DE APLICARE A MĂSURII DE PROTECŢIE ÎN CAZURILE DE VIOLENŢĂ ÎN FAMILIE

    Directory of Open Access Journals (Sweden)

    Igor COBAN

    2016-03-01

    Full Text Available Legislaţia naţională a prevăzut un cadru legislativ adecvat, ba chiar a instituit şi un fel special al procedurii civile în vederea examinării cererii de aplicare a măsurii de protecţie în cazurile de violenţă în familie. Această stare de fapt, ba chiar şi de drept, nu pare a fi una de partea victimei; or, atitudinea autorităţilor publice se dovedeşte a fi deseori ineficientă.Subiectul violenţei în familie pare a fi o provocare nu doar pentru societate, dar şi pentru  sistemul judecătoresc, idee ce se impune în rezultatul condamnărilor Republicii Moldovala CtEDOîn materie.Motiv din care prin prezentul studiu urmărim cercetarea naturii juridice a instituţiei citate ca fel de sine stătător al procedurii civile şi elucidarea particularităţilor procedurale de examinare a cererii de aplicare a măsurii de protecţie în cazurile de violenţă în familie.   THE EXAMINATION PROCEDURE OF THE APPLICATION OF THE MEASURE OF PROTECTION IN CASES OF DOMESTIC VIOLENCENational legislation provided an appropriate legislative framework, and even established a special way of civil proceedings in order to examine the application of the measure of protection in cases of domestic violence. This fact and even of law seems to be one of the victim or the attitude of public authorities often prove to be ineffective.The subject of family violence seems to be a challenge not only for society but also for the judicial system, an idea that is required as a result of convictions in the ECHR.The reason that research in this study follow the legal nature of the institution cited as independently as elucidation of the specific procedural rules of civil procedure for examining the application of the measure of protection in cases of domestic violence.

  11. Determining the Specificity of Cascade Binding, Interference, and Primed Adaptation In Vivo in the Escherichia coli Type I-E CRISPR-Cas System

    Directory of Open Access Journals (Sweden)

    Lauren A. Cooper

    2018-04-01

    Full Text Available In clustered regularly interspaced short palindromic repeat (CRISPR-Cas (CRISPR-associated immunity systems, short CRISPR RNAs (crRNAs are bound by Cas proteins, and these complexes target invading nucleic acid molecules for degradation in a process known as interference. In type I CRISPR-Cas systems, the Cas protein complex that binds DNA is known as Cascade. Association of Cascade with target DNA can also lead to acquisition of new immunity elements in a process known as primed adaptation. Here, we assess the specificity determinants for Cascade-DNA interaction, interference, and primed adaptation in vivo, for the type I-E system of Escherichia coli. Remarkably, as few as 5 bp of crRNA-DNA are sufficient for association of Cascade with a DNA target. Consequently, a single crRNA promotes Cascade association with numerous off-target sites, and the endogenous E. coli crRNAs direct Cascade binding to >100 chromosomal sites. In contrast to the low specificity of Cascade-DNA interactions, >18 bp are required for both interference and primed adaptation. Hence, Cascade binding to suboptimal, off-target sites is inert. Our data support a model in which the initial Cascade association with DNA targets requires only limited sequence complementarity at the crRNA 5′ end whereas recruitment and/or activation of the Cas3 nuclease, a prerequisite for interference and primed adaptation, requires extensive base pairing.

  12. SU-G-IeP1-13: Sub-Nyquist Dynamic MRI Via Prior Rank, Intensity and Sparsity Model (PRISM)

    International Nuclear Information System (INIS)

    Jiang, B; Gao, H

    2016-01-01

    Purpose: Accelerated dynamic MRI is important for MRI guided radiotherapy. Inspired by compressive sensing (CS), sub-Nyquist dynamic MRI has been an active research area, i.e., sparse sampling in k-t space for accelerated dynamic MRI. This work is to investigate sub-Nyquist dynamic MRI via a previously developed CS model, namely Prior Rank, Intensity and Sparsity Model (PRISM). Methods: The proposed method utilizes PRISM with rank minimization and incoherent sampling patterns for sub-Nyquist reconstruction. In PRISM, the low-rank background image, which is automatically calculated by rank minimization, is excluded from the L1 minimization step of the CS reconstruction to further sparsify the residual image, thus allowing for higher acceleration rates. Furthermore, the sampling pattern in k-t space is made more incoherent by sampling a different set of k-space points at different temporal frames. Results: Reconstruction results from L1-sparsity method and PRISM method with 30% undersampled data and 15% undersampled data are compared to demonstrate the power of PRISM for dynamic MRI. Conclusion: A sub- Nyquist MRI reconstruction method based on PRISM is developed with improved image quality from the L1-sparsity method.

  13. Closeout of IE Bulletin 84-02: Failures of General Electric Type HFA relays in use in Class 1E safety systems

    International Nuclear Information System (INIS)

    Foley, W.J.; Dean, R.S.; Hennick, A.

    1991-01-01

    Documentation is provided in this report to close IE Bulletin 84--02 regarding the failure of General Electric Type HFA relays in Class 1E safety systems. The relay failures were due to aging of coil wire insulation and nylon or Lexan spools under certain environmental conditions. The bulletin was issued to nuclear power reactor licensees and holders of construction permits to provide assurance that the manufacturer's recommendations for corrective actions would be implemented. The bulletin required four specific actions, plus a review of the general concerns of the bulletin even though some facilities had different relays from those of bulletin concern. Evaluation of utility responses, NRC/Region inspection reports, and regional telephone calls has resulted in bulletin closeout of 116 (98%) of the 118 facilities to which the bulletin was issued for action. Facilities which were shut down or had construction halted indefinitely or permanently when the report was issued are not included in this review. A follow-up item is proposed in Appendix C for the two facilities with open status. Background information is supplied in the Introduction and Appendix A

  14. Izmaksu un ieņēmumu klasifikācija un analīze mediju aģentūrā SIA "Carat"

    OpenAIRE

    Ozoliņa, Evita

    2013-01-01

    Diplomdarba tēma ir „Izmaksu un ieņēmumu klasifikācija un analīze mediju aģentūrā SIA „Carat””. Katrai Latvijas sabiedrībai (uzņēmumam) ir svarīgi apzināties tās ražošanas izmaksas, veikt šo izmaksu uzskaiti, iegrāmatošanu un turpmāko plānošanu ilgtermiņā. Reklāma ir ietekmīgs sabiedrības preces, pakalpojuma un citu objektu popularizēšanas līdzeklis. Tā kā Latvijā ekonomiskās lejupslīdes gados strauji kritās reklāmas tirgus, darba autorei ir aktuāli raksturot, pētīt un analizēt SIA „Car...

  15. Cēsu alus konkurētspēja un to ietekmējošie faktori Latvijas tirgū.

    OpenAIRE

    Baltroka, Krista

    2014-01-01

    Bakalaura darba tēma „Cēsu alus konkurētspēja un to ietekmējošie faktori Latvijas tirgū”. Konkurence ir viens no svarīgākajiem nosacījumiem uzņēmuma pilnveidošanās procesā, stratēģijas izstrādē. Latvijas tirgū, dzērienu nozarē ir liela konkurence, piedāvāto produktu klāsts ir ļoti plašs. Bakalaura darba mērķis ir izpētīt akciju sabiedrības „Cēsu alus” konkurētspēju ietekmējošos faktorus Latvijas tirgū, kā arī izstrādāt priekšlikumus konkurētspējas paaugstināšanai. Kvantitatīvās analīze...

  16. 基于“AHP-IE-PCA”组合赋权法的战略性新兴产业选择模型研究%Research on Selection Model of Strategic Emerging Industries Based on Combination Weights: AHP-IE-PCA

    Institute of Scientific and Technical Information of China (English)

    胡振华; 黎春秋; 熊勇清

    2011-01-01

    The weaknesses of AHP,IE,PCA and other selection theories and methods were analyzed during the application on strategic emerging industries.According to the specificity of selection and evaluation in strategic emerging industries,the corresponding indicator system was built.And then based on the combination weights——″AHP-IE-PCA″,the selection model of regional strategic emerging industries was tentative proposed,which was applied to N county in the selection and evaluation of strategic emerging industries.%分析了层次分析法(AHP)、信息熵法(IE)和主成分分析法(PCA)等现有产业选择与评价方法应用到区域战略性新兴产业中的不足,根据区域战略性新兴产业的选择与评价的特殊性,构建了相应的指标体系,尝试性地提出了基于"AHP-IE-PCA"组合赋权的区域战略性新兴产业选择模型,并将这一方法应用于N县战略性新兴产业的选择与评价中。

  17. The diagnosis of microorganism involved in infective endocarditis (IE by polymerase chain reaction (PCR and real-time PCR: A systematic review

    Directory of Open Access Journals (Sweden)

    Reza Faraji

    2018-02-01

    Full Text Available Broad-range bacterial rDNA polymerase chain reaction (PCR followed by sequencing may be identified as the etiology of infective endocarditis (IE from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies conducted until 2016. We searched Google Scholar, Scopus, ScienceDirect, Cochrane, PubMed, and Medline electronic databases without any time limitations up to December 2016 for English studies reporting microorganisms involved in infective endocarditis microbiology using PCR and real-time PCR. Most studies were prospective. Eleven out of 12 studies used valve tissue samples and blood cultures while only 1 study used whole blood. Also, 10 studies used the molecular method of PCR while 2 studies used real-time PCR. Most studies used 16S rDNA gene as the target gene. The bacteria were identified as the most common microorganisms involved in infective endocarditis. Streptococcus spp. and Staphylococcus spp. were, by far, the most predominant bacteria detected. In all studies, PCR and real-time PCR identified more pathogens than blood and tissue cultures; moreover, the sensitivity and specificity of PCR and real-time PCR were more than cultures in most of the studies. The highest sensitivity and specificity were 96% and 100%, respectively. The gram positive bacteria were the most frequent cause of infective endocarditis. The molecular methods enjoy a greater sensitivity compared to the conventional blood culture methods; yet, they are applicable only to the valve tissue of the patients undergoing cardiac valve surgery.

  18. Outdoor γ-ray dose rate in Shariki Village and environmental factors affecting outdoor γ-ray dose rate in IES

    International Nuclear Information System (INIS)

    Iyogi, Takashi; Hisamatsu, Shun'ichi; Inaba, Jiro

    2000-01-01

    Previously, we surveyed the outdoor γ-ray dose rate throughout Aomori Prefecture from 1992 to 1995, and found an annual mean dose rate of 51 nGy h -1 . Relatively high dose rates were also observed in several areas (municipalities) of the survey locations. In this study, we examined the detailed distribution of the γ-ray dose rate in one such high dose rate area, Shariki Village. Glass dosemeters were used for the monitoring of cumulative γ-ray dose rate at 10 locations in the village. The dose rate from each radioactive nuclide in the ground at the monitoring locations was measured by using an in situ γ-ray spectrometer with a Ge detector. The results obtained with the glass dosemeters showed that the γ-ray dose rates in Shariki Village varied from 49 to 55 nGy h -1 . Although the dose rates were generally higher than the mean dose in Aomori Prefecture (1992-1995), the rates were lower than other high dose rate areas which had already been measured. The in situ γ-ray spectrometry revealed that these relatively high dose rates were mainly caused by 40 K and Th series radionuclides in the village. The effect of meteorological conditions on the γ-ray dose rate was studied at a monitoring station in the IES site. The dose rate was continuously recorded by a DBM NaI(Tl) scintillation detector system. The mean dose rate obtained when precipitation was sensed was 27 nGy h -1 and higher than when no precipitation was sensed (25 nGy h -1 ). (author)

  19. The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review.

    Science.gov (United States)

    Faraji, Reza; Behjati-Ardakani, Mostafa; Moshtaghioun, Seyed Mohammad; Kalantar, Seyed Mehdi; Namayandeh, Seyedeh Mahdieh; Soltani, Mohammadhossien; Emami, Mahmood; Zandi, Hengameh; Firoozabadi, Ali Dehghani; Kazeminasab, Mahmood; Ahmadi, Nastaran; Sarebanhassanabadi, Mohammadtaghi

    2018-02-01

    Broad-range bacterial rDNA polymerase chain reaction (PCR) followed by sequencing may be identified as the etiology of infective endocarditis (IE) from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies conducted until 2016. We searched Google Scholar, Scopus, ScienceDirect, Cochrane, PubMed, and Medline electronic databases without any time limitations up to December 2016 for English studies reporting microorganisms involved in infective endocarditis microbiology using PCR and real-time PCR. Most studies were prospective. Eleven out of 12 studies used valve tissue samples and blood cultures while only 1 study used whole blood. Also, 10 studies used the molecular method of PCR while 2 studies used real-time PCR. Most studies used 16S rDNA gene as the target gene. The bacteria were identified as the most common microorganisms involved in infective endocarditis. Streptococcus spp. and Staphylococcus spp. were, by far, the most predominant bacteria detected. In all studies, PCR and real-time PCR identified more pathogens than blood and tissue cultures; moreover, the sensitivity and specificity of PCR and real-time PCR were more than cultures in most of the studies. The highest sensitivity and specificity were 96% and 100%, respectively. The gram positive bacteria were the most frequent cause of infective endocarditis. The molecular methods enjoy a greater sensitivity compared to the conventional blood culture methods; yet, they are applicable only to the valve tissue of the patients undergoing cardiac valve surgery. Copyright © 2017. Published by Elsevier Taiwan.

  20. Evaluation of responses to IE Bulletin 82-02: degradation of threaded fasteners in reactor coolant pressure boundary of pressurized-water-reactor plants

    International Nuclear Information System (INIS)

    Anderson, W.; Sterner, P.

    1985-05-01

    IE Bulletin 82-02 was issued by the NRC on June 2, 1982, to notify licensees about incidents of severe degradation of threaded fasteners. The bulletin required appropriate action including submittal of information from pressurized water reactors having an operating license. Responses from 41 licensees included their recent experience with degradation of threaded fasteners in primary system components. Data from recent regular inspections of reactor coolant pressure boundary component connections of 6-in. size and larger are compiled for technical evaluation. Statistical analysis is used to determine significant factors related to frequency of leakage incidents in connections, occurrence of degradation of bolts and studs, and the need for bolt replacement. Factors examined include the age of the plant, types of components, use of lubricants and sealants, and differences between plants. The compiled data indicate that, on the average, 10% of the bolted connections show evidence of leaking during an 18-month period. Also, 80% of the connections that show evidence of leakage undergo some degradation of the bolting. Results of the analysis show a significant decrease in the occurrence of bolting degradation events as the age of the plant increases. The data also show that valves are less subject to bolting corrosion. A group of 5 of the 41 plants accounted for about one-half of the reported leakage and corrosion events. The common characteristic found for four of these five plants was the lubricant used. The use of nickel-graphite based lubricants appears to offer a significantly reduced incidence of leakage and corrosion, based on late corrections to the reported data. The data also permit the conclusion that the use of molybdenum-disulfide-based lubricants and graphite-based lubricants results in a significantly increased incidence of leakage and corrosion. Reporting of data on lubricants was of poor quality and detracted from the value of the bulletin responses

  1. Outdoor γ-ray dose rate in Mutsu city and environmental factors affecting outdoor γ-ray dose rate in IES

    International Nuclear Information System (INIS)

    Iyogi, Takashi; Hisamatsu, Shun'ichi; Inaba, Jiro

    2001-01-01

    Previously, we surveyed outdoor γ-ray dose rates throughout Aomori Prefecture from 1992 to 1995, and found a mean annual dose rate of 28 nGy h -1 . Relatively high dose rates were also observed in several areas (municipalities) of the survey locations. In this study, we examined the detailed distribution of the γ-ray dose rate in one such high dose rate area, Mutsu City. Glass dosemeters were used for the monitoring of cumulative γ-ray dose rate at 10 locations in the city. The dose rate from each radioactive nuclide in the ground at the monitoring locations was measured by using an in situ γ-ray spectrometer with a Ge detector. The results obtained with the glass dosemeters showed that the γ-ray dose rates in Mutsu City varied from 17 to 32 nGy h -1 . Although the dose rates were almost the same as the mean dose in Aomori Prefecture (1992-1995), the rates were lower than other high dose rate areas which had already been measured. The in situ γ-ray spectrometry revealed that these relatively high dose rates were mainly caused by 40 K and Th series radionuclides in the local ground. The effect of meteorological conditions on the γ-ray dose rate was studied at a monitoring station in the IES site. The dose rate was continuously recorded by a DBM NaI(Tl) scintillation detector system. The mean dose rate obtained when precipitation was sensed was 26 nGy h -1 and higher than when no precipitation was sensed (24 nGy h -1 ). (author)

  2. MO-FG-CAMPUS-IeP2-03: Validation of an SSDE-To-Organ-Dose Calculation Methodology Developed for Pediatric CT in An Adult Population

    Energy Technology Data Exchange (ETDEWEB)

    Mead, H [Christian Brothers University, Memphis, TN (United States); St. Jude Children’s Research Hospital, Memphis, TN (United States); Brady, S; Kaufman, R [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2016-06-15

    Purpose: To discover if a previously published methodology for estimating patient-specific organ dose in a pediatric population (5–55kg) is translatable to the adult sized patient population (> 55 kg). Methods: An adult male anthropomorphic phantom was scanned with metal oxide semiconductor field effect transistor (MOSFET) dosimeters placed at 23 organ locations in the chest and abdominopelvic regions to determine absolute organ dose. Organ-dose-to-SSDE correlation factors were developed by dividing individual phantom organ doses by SSDE of the phantom; where SSDE was calculated at the center of the scan volume of the chest and abdomen/pelvis separately. Organ dose correlation factors developed in phantom were multiplied by 28 chest and 22 abdominopelvic patient SSDE values to estimate organ dose. The median patient weight from the CT examinations was 68.9 kg (range 57–87 kg) and median age was 17 years (range 13–28 years). Calculated organ dose estimates were compared to published Monte Carlo simulated patient and phantom results. Results: Organ-dose-to-SSDE correlation was determined for a total of 23 organs in the chest and abdominopelvic regions. For organs fully covered by the scan volume, correlation in the chest (median 1.3; range 1.1–1.5) and abdominopelvic (median 0.9; range 0.7–1.0) was 1.0 ± 10%. For organs that extended beyond the scan volume (i.e. skin bone marrow and bone surface) correlation was determined to be a median of 0.3 (range 0.1–0.4). Calculated patient organ dose using patient SSDE agreed to better than 6% (chest) and 15% (abdominopelvic) to published values. Conclusion: This study demonstrated that our previous published methodology for calculating organ dose using patient-specific SSDE for the chest and abdominopelvic regions is translatable to adult sized patients for organs fully covered by the scan volume.

  3. SU-G-IeP4-10: Microimaging for Different Degrees of Human Cavernous Hemangioma of Liver by Using In-Line Phase-Contrast Imaging CT

    International Nuclear Information System (INIS)

    Duan, J

    2016-01-01

    Purpose: Cavernous hemangioma of the liver (CHL) is the most common benign solid tumor of the liver. In this study, we quantitative assessment the different degrees of CHL from microscopic viewpoint by using in-line phase-contrast imaging CT (ILPCI-CT). Methods: The experiments were performed at x-ray imaging and biomedical application beamline (BL13W1) of Shanghai Synchrotron Radiation Facility (SSRF) in China. Three typical specimens at different stages, i.e., mild, moderate and severe human CHL were imaged using ILPCI-CT at 16keV without contrast agents. The 3D visualization of different degrees of CHL samples were presented using ILPCI-CT. Additionally, quantitative evaluation of the CHL features, such as the range of hepatic sinusoid equivalent diameters in different degrees of CHL samples, the ratio of the hepatic sinusoid to the CHL tissue, were measured. Results: The planar image clearly displayed the dilated hepatic sinusoids in microns. There was no normal hepatic vascular found in the all CHL samples. Different stages of CHL samples were presented with vivid shapes and stereoscopic effects by using 3D visualization. The equivalent diameters of hepatic sinusoids in three degrees CHL were different. The equivalent diameters of the hepatic sinusoids in mild CHL, range from 60 to 120 µm. The equivalent diameters of the hepatic sinusoids in moderate CHL, range from 65 to 190 µm. The equivalent diameters of the hepatic sinusoids in severe CHL, range from 95 to 215 µm. The ratio of the hepatic sinusoid to the mild, moderate and severe CHL tissue were 3%, 16% and 21%, respectively. Conclusion: The results show that the high degree of sensitivity of the ILPCI-CT technique and demonstrate the feasibility of accurate visualization of different stage human CHL. ILPCI-CT may offers a potential use in non-invasive study and analysis of CHL.

  4. Number 13 / Part I. Music. 8. The Development of Music-Pedagogical Education of Ukraine in The 60's –70-ies of The XX Century

    Directory of Open Access Journals (Sweden)

    Cherkasov Vladimir

    2017-03-01

    Full Text Available The article has analyzed and systematized the development of musical-pedagogical education in Ukraine in the 60's -70-ies of XX century. It has summarized the experience of training of specialists with higher musical-pedagogical education at the faculties of Humanities, where the 50's - 60's graduates received diplomas of philologists, historians, geographers with additional qualification of a teacher of music and singing. It has also been grounded the establishment of the first musical-pedagogical faculties at educational institutions in different regions of Ukraine (Kyiv, Luhansk, Drohobych, Odesa, Zaporozhia. Having based on the analysis of the archival documents it has been revealed the main directions of the formation of teaching staff of specialized departments, organization of the educational process, creation of the art groups, participation of students in research work, teaching practice at secondary schools. It has been proved the importance of concert performance and musical educational work in the pedagogical formation of prospective teachers of music and singing. Their role in raising the level of musical and aesthetic education of children and youth in the 60's of last century has been proved. The 70‟s years of the twentieth century of the history of Ukraine are known as the years of corresponding changes in the socio-political processes, "thaw" in all spheres of life, particularly in the organization of higher education activity. This period of musical-pedagogical education is characterized by democratization and the search for more advanced forms of the educational-upbringing process.

  5. VERIFICAREA AUTENTICITĂȚII INFORMAȚIONALE A PURTĂTORILOR TEHNICO-ELECTRONICI DE INFORMAȚIE ÎN PROBATORIUL PENAL

    Directory of Open Access Journals (Sweden)

    Elena CROITOR

    2017-07-01

    Full Text Available Probatoriul penal presupune etape și elemente de a căror respectare depinde, indubitabil, justa soluționare a cauzei penale. Codul de procedură penală în vigoare reglementează cu titlu de obligație a subiectului oficial, care administrează și apreciază proba, verificarea acesteia din punctul de vedere al veridicității. Totodată, în virtutea varietăților sub care se prezintă purtătorii tehnico-electronici de informație, pe de o parte, și datorită complexității activității de dobândire și introducere în proces, pe de alta, activitatea de verificare depășește limitele procesului penal, realizând incursiuni nu doar în criminalistică, ci și în tehnică.Astfel, pornind de la cele enunțate, verificarea se realizează atât din perspectivă procesuală, cât și din punctul de vedere al condițiilor de ordin tehnic, de care depinde nu doar autenticitatea, cât, mai ales, admisibilitatea probei.Diferite genuri ale expertizei criminalistice permit, la etapa actuală, identificarea existenței unor manipulări de oarecare natură în conținutul înregistrării audio-video fixate pe un anumit suport tehnico-electronic de informație, indiferent dacă au fost realizate prin montaj, prin adăugarea sau excluderea textului, fie prin intervenții de alt fel. Pe de altă parte, falsul intelectual devine detectabil, în principal, prin intermediul unei verificări procesuale, altfel spus – prin aprecierea probelor în colaborare sau prin realizarea unor procedee probatorii. Faptul dat nu exclude posibilitatea identificării unor indicii în acest sens, prin intermediul unor expertize tehnice, fonoscopice, computerizate şi al., care ar pune la îndoială rezonabilă autenticitatea probelor electronice administrate pentru soluționarea cauzei penale.THE AUTHENTICITY VALIDATION OF THE INFORMATION PROVIDED BY ELECTRONIC DATA CARIRERS IN CRIMINAL PROCEEDINGSFor the fair settlement of the criminal case, the criminal procedural

  6. SU-G-IeP2-08: Investigation On Signal Detectability in Volumetric Cone Beam CT Images with Anatomical Background

    International Nuclear Information System (INIS)

    Han, M; Baek, J

    2016-01-01

    Purpose: To investigate the slice direction dependent detectability in cone beam CT images with anatomical background. Methods: We generated 3D anatomical background images using breast anatomy model. To generate 3D breast anatomy, we filtered 3D Gaussian noise with a square root of 1/f"3, and then assigned the attenuation coefficient of glandular (0.8cm"−"1) and adipose (0.46 cm"−"1) tissues based on voxel values. Projections were acquired by forward projection, and quantum noise was added to the projection data. The projection data were reconstructed by FDK algorithm. We compared the detectability of a 3 mm spherical signal in the image reconstructed from four different backprojection Methods: Hanning weighted ramp filter with linear interpolation (RECON1), Hanning weighted ramp filter with Fourier interpolation (RECON2), ramp filter with linear interpolation (RECON3), and ramp filter with Fourier interpolation (RECON4), respectively. We computed task SNR of the spherical signal in transverse and longitudinal planes using channelized Hotelling observer with Laguerre-Gauss channels. Results: Transverse plane has similar task SNR values for different backprojection methods, while longitudinal plane has a maximum task SNR value in RECON1. For all backprojection methods, longitudinal plane has higher task SNR than transverse plane. Conclusion: In this work, we investigated detectability for different slice direction in cone beam CT images with anatomical background. Longitudinal plane has a higher task SNR than transverse plane, and backprojection with hanning weighted ramp filter with linear interpolation method (i.e., RECON1) produced the highest task SNR among four different backprojection methods. This research was supported by the MSIP (Ministry of Science, ICT and Future Planning), Korea, under the IT Consilience Creative Programs(IITP-2015-R0346-15-1008) supervised by the IITP (Institute for Information & Communications Technology Promotion), Basic Science

  7. SU-G-IeP2-08: Investigation On Signal Detectability in Volumetric Cone Beam CT Images with Anatomical Background

    Energy Technology Data Exchange (ETDEWEB)

    Han, M; Baek, J [Yonsei University, Incheon (Korea, Republic of)

    2016-06-15

    Purpose: To investigate the slice direction dependent detectability in cone beam CT images with anatomical background. Methods: We generated 3D anatomical background images using breast anatomy model. To generate 3D breast anatomy, we filtered 3D Gaussian noise with a square root of 1/f{sup 3}, and then assigned the attenuation coefficient of glandular (0.8cm{sup −1}) and adipose (0.46 cm{sup −1}) tissues based on voxel values. Projections were acquired by forward projection, and quantum noise was added to the projection data. The projection data were reconstructed by FDK algorithm. We compared the detectability of a 3 mm spherical signal in the image reconstructed from four different backprojection Methods: Hanning weighted ramp filter with linear interpolation (RECON1), Hanning weighted ramp filter with Fourier interpolation (RECON2), ramp filter with linear interpolation (RECON3), and ramp filter with Fourier interpolation (RECON4), respectively. We computed task SNR of the spherical signal in transverse and longitudinal planes using channelized Hotelling observer with Laguerre-Gauss channels. Results: Transverse plane has similar task SNR values for different backprojection methods, while longitudinal plane has a maximum task SNR value in RECON1. For all backprojection methods, longitudinal plane has higher task SNR than transverse plane. Conclusion: In this work, we investigated detectability for different slice direction in cone beam CT images with anatomical background. Longitudinal plane has a higher task SNR than transverse plane, and backprojection with hanning weighted ramp filter with linear interpolation method (i.e., RECON1) produced the highest task SNR among four different backprojection methods. This research was supported by the MSIP (Ministry of Science, ICT and Future Planning), Korea, under the IT Consilience Creative Programs(IITP-2015-R0346-15-1008) supervised by the IITP (Institute for Information & Communications Technology Promotion

  8. Counter-IED Initiative PPE Horizon 0, Phase 1, Protection Versus Performance Preliminary Trade-off Analysis, Behavioural Task Analysis (Initiative d’epi pour la Lutte aux IED - Horizon 0 Phase 1 - Analyse de Compromis Preliminaire de la Protection par Rapport au Rendement Analyse Comportementale des Taches)

    Science.gov (United States)

    2007-05-01

    fournit les connaissances spécialisées en ergonomie pour soutenir ce projet. Afin de formuler des recommandations relativement à l’EPI pour corriger...important. RDDC Toronto fournit les connaissances spécialisées en ergonomie pour soutenir ce projet. Afin de formuler des recommandations relativement à...Programme de démonstration de technologie (PDT) de C−IED plus important. RDDC Toronto fournit les connaissances spécialisées en ergonomie pour soutenir

  9. Measuring symptoms of post-traumatic stress disorder in people with intellectual disabilities: the development and psychometric properties of the Impact of Event Scale-Intellectual Disabilities (IES-IDs).

    Science.gov (United States)

    Hall, James C; Jobson, Laura; Langdon, Peter E

    2014-09-01

    The aims of the study were to (1) revise the Impact of Event Scale-Revised for use with people with intellectual disabilities (IDs), creating the Impact of Event Scale-Intellectual Disabilities (IES-IDs), (2) assess the reliability of the IES-IDs, and (3) compare the IES-IDs to an existing measure trauma-related symptomatology, namely the Lancaster and Northgate Trauma Scale (LANTS), along with measures of anxiety and depression. Forty adults with IDs who had experienced at least one traumatic event were recruited and completed the IES-IDs and the LANTS on two occasions, separated by 2 weeks. Participants also completed the Glasgow Depression Scale and the Glasgow Anxiety Scale, along with the Trauma Information Form which was used to collect information about trauma history. Fifteen per cent of the sample had encountered five or more traumatic events. The IES-IDs and the LANTS had good to excellent internal consistency and test-retest reliability. Both measures correlated with self-report measures of depression and anxiety, although the strength of this correlation was greater with the LANTS. There was a significant positive correlation between trauma frequency and the IES-IDs, while trauma frequency did not correlate with the LANTS. Both the IES-IDs and the LANTS appear to have good reliability. There is a lack of well-developed questionnaires that can be used to assess symptoms of post-traumatic stress disorder (PTSD) in people with intellectual disabilities. The Impact of Event Scale-Revised was augmented creating the Impact of Event Scale-Intellectual Disabilities (IES-IDs). The IES-IDs was shown to have good psychometric properties. The IES-IDs was compared to the Lancaster and Northgate Trauma Scale (LANTS), but the LANTS did not correlate with trauma frequency. However, this study had a small sample size, and a much larger study is needed to examine the factor structure of both the IES-IDs and the LANTS. Future studies should attempt to recruit people with

  10. Industrial Ecology (IE) Revisited: Beyond Environmental Myopia

    DEFF Research Database (Denmark)

    Bojsen, Inger; Ulhøi, John Parm

    Since the late 1980s, the notion of industrial ecology has attracted increasing attention amoung researchers, most notably in the US and northern Europe. However, this is not yet translated into any significant political or practical awareness in the industrial community. There are several reasons...

  11. Succession Planning Demystified. IES Report 372.

    Science.gov (United States)

    Hirsh, W.

    This book, which is designed for human resource (HR) practitioners, details the principles and applications of succession planning, shows how succession planning is conducted, and explains its place in relation to other HR processes and business priorities. The introduction describes the book's intended audience and provides a brief overview of…

  12. Antisocial behavior: Dimension or category(ies?

    Directory of Open Access Journals (Sweden)

    Biro Mikloš

    2008-01-01

    Full Text Available Classificatory systems (DSM-IV, ICD-10 use different criteria for defining a rather common antisocial disorder, traditionally referred as psychopathy. Most empirical studies of this phenomenon use Cleckley's operational definition that was applied and amended in Hare's revised Psychopathy Checklist (PCL-R. In modern literature, the fact that there is less than a perfect correspondence between classificatory systems and Hare's PCL-R is often cited as an indication that antisocial behavior is not confined to a distinct category of people but is rather a continuous personality dimension. In order to further elucidate the nosology of antisocial behaviors, a Psychopathy Assessment Questionnaire (PAQ based on Cleckley - Hare's criteria and consisting of 40 binary items was administered to 339 men (135 prisoners and 204 members of the general population. Four distinct clusters of respondents were identified by means of hierarchical cluster analysis: Psychopathic type (characterized by high positive scores on dimension of Unemotionality; Antisocial type (characterized by high positive scores on Social deviance dimension; Adapted type (characterized by negative scores on all dimensions; and Hyper-controlled type (characterized by extremely negative scores on dimension Social deviance accompanied with positive scores on Unemotionality dimension. Additional comparison with MMPI profiles which classified prison sample in two groups ("Psychopathic profiles" and "Non- Psychopathic profiles" shows that there is no expected compatibility between MMPI and PAQ. We conclude that Antisocial type can be treated as a distinct category, while Psychopathic type displays characteristics of dimensional distribution.

  13. Modern Resource-Based Theory(ies)

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Stieglitz, Nils

    We survey the resource-based view in strategic management, focusing on its roots in economics. We organize our discussion in terms of the Gavetti and Levinthal distinction between a “high church” and a “low church” resource-based view, and argue that these hitherto rather separate streams...

  14. [)IE SUI[).AFRIKAA~SE LEERKOLLEGE

    African Journals Online (AJOL)

    van die gebou waarin die skool gehuisves is ondersoek word. Net na die verowering van Pretoria in 1900 het die Britse besettingsmagte. 'n soldate- kantien op die ou Markplein aan die Kerk- straatkant in Pretoria opgerig. In die twee jaar wat daarop gevolg het, is 'n wins van. £20000 gemaak en het lord Kitchener besluit.

  15. OFICIUL EUROPEAN DE POLIŢIE - EUROPOL

    Directory of Open Access Journals (Sweden)

    Angelica Chirila

    2008-05-01

    Full Text Available Europol is the European Law Enforcement Organisation which aims at improving theeffectiveness and co-operation of the competent authorities in the Member States in preventing and combatingterrorism, unlawful drug trafficking and other serious forms of international organised crime.The establishment of Europol was agreed in the Maastricht Treaty on European Union of 7 February1992. Based in The Hague, Netherlands, Europol started limited operations on 3 January 1994 in the form of theEuropol Drugs Unit (EDU fighting against drugs. Progressively, other important areas of criminality wereadded. On 1 January 2002, the mandate of Europol was extended to deal with all serious forms of internationalcrime as listed in the annex to the Europol Convention. The Europol Convention was ratified by all MemberStates and came into force on 1 October 1998. Following a number of legal acts related to the Convention,Europol commenced its full activities on 1 July 1999.

  16. PARTICIPAREA PAREMIOLOGIEI LA EDUCAŢIE

    Directory of Open Access Journals (Sweden)

    Letiţia DURNEA

    2018-03-01

    Full Text Available În contextul educațional actual, materialele de sprijin al învăţământului românesc (manuale, auxiliare, caiete speciale abordează diverse subiecte, unele de ajutor schimbărilor aduse de evoluţia pe diverse planuri, altele de completare a acestora. Susţinem că paremiologia poate fi un suport concret al educaţiei şi astfel se conturează principalul motiv pentru care ne-am propus studiul amănunţit al expresiilor paremiologice în contextul educaţiei. Cadrele didactice au parte de o provocare atunci când interesele şi preocupările copiilor nu sunt subtil orientate de conţinuturile pe care şcoala trebuie să le furnizeze, conforme cu programele şcolare. Un început al soluţiei îşi propune să ofere acest studiu, prin identifi­ca­rea parimiilor în manualele şcolare şi stabilirea dominanţei subiectelor abordate. Proverbele – forme de expresie populară, ascund sensuri de multe ori neînţelese din cauza barierei semantice, întrucât ele operează uneori cu termeni a căror actualitate este depăşită, mai ales pentru elevii din mediul urban. Însă, apelul la proverbe nu pare imposibil, copiii dau dovadă de disponibilitate şi înţelegere, în contextul explicării termenilor şi mesajelor pe care le transmit.THE PARTICIPATION OF PAREMIOLOGY IN EDUCATIONIn the current educational context, the support materials of the Romanian schooling (manuals, auxiliaries, special notebooks approach various topics. Some of them have contributed to the changes brought to developments on different plans, others just completing them. We argue that paremiology can be a concrete support of education and thus outlines the main reason why we have proposed a thorough study of paremiological expressions in the context of education. Teachers face a challenge when the interests and concerns of children are not subtly focused on the content that the school has to provide in line with the curricula. This study aims to provide a start of the solution by identifying para­phra­ses in school textbooks and establishing the dominance of the topics addressed. Proverbs - forms of popular expression - often conceal pointless meanings because of the semantic barrier. Sometimes they operate with terms that are outdated, especially for urban students. Concluding, the call to proverbs does not seem impossible. Students demonstrate willingness and understanding in the context of explaining the terms and messages they transmit and this is a good reason for us to study the role of these folk elements in education.

  17. POLÍTICAS E INCENTIVOS AO EMPREENDEDORISMO EM INSTITUIÇÕES DE ENSINO SUPERIOR (IES - UMA NOVA ABORDAGEM PARA A GESTÃO EDUCACIONAL [doi: 10.5329/RECADM.20030201006

    Directory of Open Access Journals (Sweden)

    Günther Lother Pertschy

    2003-05-01

    Full Text Available RESUMO Este artigo aborda as principais bases do empreendedorismo, as características preponderantes do empreendedor e a relação desses últimos com as instituições de ensino superior (IES. Advogamos aqui o empreendedorismo, como uma vantagem competitiva quando bem desenvolvido por meio de políticas e incentivos de amplo espectro e de fontes diversas. Discutimos aqui um rol de políticas e diferentes formas de incentivo ao empreendedorismo em IES. Esta análise nos permite concluir que o desenvolvimento e expansão das IES, hoje, dependem mais de uma atitude empreendedora, ou um movimento empreendedor de dentro para fora, lastreado em parcerias devidamente planejadas, na excelência ou qualidade de seus produtos/serviços e na visão do negócio educacional como sustentação da educação, do que na simples racionalização de seus custos operacionais. Por fim, mostramos que atitude empreendedora traz vantagens competitivas inigualáveis para as IES, especialmente para as chamadas "Faculdades Integradas e Isoladas", mais ágeis, com estruturas enxutas e menos custosas. Palavras-chave:empreendedor; empreendedorismo; empreendedorismo e IES; políticas e empreendedorismo; incentivo ao empreendedorismo

  18. Inteligencia emocional y relaciones interpersonales en estudiantes de 6° grado de primaria de la I.E. N° 6031 “Santa María de Lurín”- distrito de Lurín, 2015

    OpenAIRE

    Salinas Salinas, Roberto Juan

    2016-01-01

    Este estudio responde al problema general: ¿Existe relación directa y significativa entre la inteligencia emocional y las relaciones interpersonales en estudiantes de 6° grado de primaria de la I.E N° 6031 “Santa María de Lurín”, 2015? Y tuvo como objetivo determinar la relación entre la inteligencia emocional las relaciones interpersonales en estudiantes de 6° grado de primaria de la I.E N° 6031 “Santa María de Lurín”, 2015. El estudio ha sido de tipo básica sustantiva y de...

  19. Influencia de los Factores en la Aceptación de la Vacunación contra el Virus Papiloma Humano en Padres de Familia de Escolares de las I.E. Secundarias de Juliaca 2014

    OpenAIRE

    Beltrán Beltrán, Rosita Graciela

    2016-01-01

    La investigación efectuada trata específicamente sobre la influencia de los factores en la aceptación de la vacunación contra el virus papiloma humano en padres de familia de escolares de las I.E. secundarias de la ciudad de Juliaca durante el año 2014. El propósito del trabajo de investigación ha sido determinar la medida en que el nivel de influencia de los factores en la aceptación de la vacunación contra el virus papiloma humano en padres de familia de escolares de las I.E. secund...

  20. Autoestima y motivación en el rendimiento académico de los estudiantes de la I.E “Rodríguez Trigoso” SMP- 2015

    OpenAIRE

    Fonseca Rosales, Ruth Elizabeth

    2017-01-01

    La investigación titulada Autoestima y motivación en el rendimiento académico en los estudiantes del segundo grado de secundaria la I.E “Rodríguez Trigoso” SMP- 2015”, tiene como problema general ¿Cuál es la influencia de la autoestima y la motivación en el rendimiento académico de los estudiantes del segundo grado de secundaria la I.E “Rodríguez Trigoso” SMP-2015? La metodología empleada fue de un tipo básica-descriptivo- correlacional causal; un diseño no experimental tran...

  1. Divulgación on-line de los códigos de buen gobierno en las IES y su determinación para el posicionamiento en el ranking QS

    OpenAIRE

    Méndez Beltrán, Jairo Andrés

    2015-01-01

    Dado el interés que se presenta con los temas de gobierno corporativo, este trabajo busca describir si la divulgación on-line de los contenidos de los códigos de buen gobierno, es determinante en el posicionamiento que tienen las Instituciones de Educación Superior (IES) en el ranking QS. Partiendo de una muestra de 20 IES, se recolectaron un conjunto de datos dicotómicos para 30 variables independientes y se relacionaron con la variable dependiente denominada posicionamiento en el ranking. A...

  2. Conjugal transfer of aac(6')Ie-aph(2″)Ia gene from native species and mechanism of regulation and cross resistance in Enterococcus faecalis MCC3063 by real time-PCR.

    Science.gov (United States)

    Jaimee, G; Halami, P M

    2017-09-01

    High level aminoglycoside resistance (HLAR) in the lactic acid bacteria (LAB) derived from food animals is detrimental. The aim of this study was to investigate the localization and conjugal transfer of aminoglycoside resistance genes, aac(6')Ie-aph(2″)Ia and aph(3')IIIa in different Enterococcus species. The cross resistance patterns in Enterococcus faecalis MCC3063 to clinically important aminoglycosides by real time PCR were also studied. Southern hybridization experiments revealed the presence of aac(6')Ie-aph(2 ″ )Ia and aph(3')IIIa genes conferring HLAR in high molecular weight plasmids except in Lactobacillus plantarum. The plasmid encoded bifunctional aac(6')Ie-aph(2″)Ia gene was transferable from Enterococcus avium (n = 2), E. cecorum (n = 1), E. faecalis (n = 1) and Pediococcus lolii (n = 1) species into the recipient strain; E. faecalis JH2-2 by filter mating experiments thus indicating the possible risks of gene transfer into pathogenic strains. Molecular analysis of cross resistance patterns in native isolate of E. faecalis MCC3063 carrying aac(6')Ie-aph(2″)Ia and aph(3')IIIa gene was displayed by quantification of the mRNA levels in this study. For this, the culture was induced with increasing concentrations of gentamicin, kanamycin and streptomycin (2048, 4096, 8192, 16384 μg/mL) individually. The increasing concentrations of gentamicin and kanamycin induced the expression of the aac(6')Ie-aph(2″)Ia and aph(3')IIIa resistance genes, respectively. Interestingly, it was observed that induction with streptomycin triggered a significant fold increase in the expression of the aph(3')IIIa gene which otherwise was not known to modify the aminoglycoside. This is noteworthy as streptomycin was found to confer cross resistance to structurally unrelated kanamycin. Also, expression of the aph(3')IIIa gene when induced with streptomycin, revealed that bacteria harbouring this gene will be able to overcome streptomycin bactericidal action at

  3. Ações em prol à sustentabilidade: estudo sobre a agenda 21 catarinense no curso de Ciências Contábeis nas IES privadas de Florianópolis

    Directory of Open Access Journals (Sweden)

    Marcela Monteiro

    2013-08-01

    Full Text Available A problemática deste estudo fica resumida na seguinte questão problema: Como se encontra o comprometimento e o desenvolvimento de ações em prol à sustentabilidade, em Instituições de Ensino Superior? Nesta perspectiva, este artigo tem por objetivo geral, analisar o comportamento das Instituições de Ensino Superior (IES de Florianópolis, que ofertam o Curso de Ciências Contábeis, privadas e presenciais, em relação a ações em prol à sustentabilidade, com base na Agenda 21 Catarinense. Para atender a este objetivo geral, têm-se os seguintes objetivos específicos: verificar a aderência dos critérios com base nesta Agenda; identificar as práticas desenvolvidas pelas Instituições de Ensino analisadas, com base nos ditames desta Agenda e averiguar se as IES, que não possuem, têm interesse em construir a sua própria Agenda. Quanto à metodologia, a pesquisa caracteriza-se como descritiva, indutiva, com coleta de dados primária, através de questionário, tendo abordagem qualitativa e quantitativa. A população e amostra, deste estudo, contêm cinco IES, ou seja, representam 100% (cem por cento de amostragem. No que se refere aos resultados, quanto ao primeiro objetivo específico; identifica-se que as IES possuem aderência a critérios em prol à sustentabilidade. Em relação ao segundo objetivo específico, percebe-se que as práticas comuns nas IES são simples em relação a gama de possibilidades existentes. No terceiro e último objetivo específico, observa-se que, 60% (sessenta por cento das IES possuem interesse em desenvolver a sua Agenda 21. Conclui-se assim, que os gestores destas IES possuem ideais sustentáveis.

  4. Novas formas de relação com a sociedade por meio da identificação de atributos que compõem a personalidade da marca de uma IES

    Directory of Open Access Journals (Sweden)

    Gustavo da Rosa Borges

    2015-02-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2015v8n1p25 A personalidade da marca de uma IES é uma forma que a mesma tem de se comunicar com a sociedade (DA ROCHA e ALPERSTEDT, 2006, sendo um assunto debatido no marketing (SUNG e KIM, 2010. Admitindo a necessidade de uma IES trabalhar de uma forma eficiente a sua gestão de marketing (Kotler e Fox 1996; TORRES, 2004; HARMON e WEBTSTER, 2007; BRAVIN e IKEDA, 2010; HAMMOND; BRAVIN e IKEDA, 2010; ZEBAL e GOODWIN, 2012, e principalmente a sua comunicação com a sociedade, o presente artigo buscou estudar como os alunos percebem a personalidade de marca em uma Instituição de Ensino Superior (IES localizada no interior de Santa Catarina. Para tanto, realizou-se duas abordagens qualitativas do tipo focus group com 43 alunos de graduação dos cursos de graduação em pedagogia, letras, matemática e história. Os resultados revelaram haver mais 52 atributos que podem ser uma característica humana a uma determinada marca (personalidade, especificamente para IES. Por meio de estudos bibliográficos em outras pesquisas similares, observou-se a existência de 144 atributos que podem representar a personalidade de uma marca. A adoção de personalidade de marcar por uma IES faz parte de uma perspectiva recente que busca uma melhor identificação da mesma no mercado.

  5. Postirradiation examination results for the Irradiation Effects Test Series IE-ST-2, Rod IE-002

    International Nuclear Information System (INIS)

    Murdock, B.A.

    1977-12-01

    A postirradiation examination was conducted on a zircaloy-clad, UO 2 -fueled, pressurized water reactor (PWR) type rod which had been tested in the Power Burst Facility as part of the Irradiation Effects Test Series of the Thermal Fuels Behavior Program. The fuel rod, previously irradiated to a burnup of 15,800 MWd/t was subjected to a power ramp from 28 to 55 kW/m peak power at an average ramp rate of 4 kW/m/min. Posttest fuel restructuring and relocation, fission product redistribution, and fuel rod cladding deformation were evaluated and analyzed

  6. SP EN GE LB RECHT . VRUCHTENVANDERE FO RMAT IE .* W ie ...

    African Journals Online (AJOL)

    Test

    ?e^ormaite (1943) té lezen om onder den indruk te komen van hun kracht. Die kracht brak de beelden en nog vele andere dingen. Het oorspronkelijke Calvinisme is ten onzent eerst destructief, dan pas constructief. Het is revolutionnair en ...

  7. BIO GRA PIEË VAN SE WENT IE NDE EN AGT IE NDEEEUSE SU ID

    African Journals Online (AJOL)

    Test

    den Raad aangewezen en vertoond eene bekwame gelegenheid, in 's. Comp. verlaten Tuin, om aldaar eene goede begrafenisplaats te ordin- neren. en daar ter plaatse door de Diaconie, of de Ed. Comp. vooreerst een ommuurd Kerkhof, en met ter tijd een behoorlijk proper kerkje te laten maken, waarin de gequalificeerde ...

  8. GJJ RO O S. B IO G RA FIEË VANSEWENT IE NDE EN AGT IE NDE ...

    African Journals Online (AJOL)

    Test

    Keyserskindt bedien is. Hierdie lang tyd van twintig maande het vol- gens die dagregister van die Kommandeur n geestehke agteruitgang veroorsaak. sodat nou slegs vier-en-twintig persone aan die nag- maal deelgeneem het, hoewel daar 'n groot garnisoen was en baie burgers en boere. Maar toe ds. Van Arckel op 25 ...

  9. La alfabetización informacional en las Universidades-IES peruanas: Visualización de los niveles de incorporación desde la información publicada en los sitios web de sus bibliotecas

    Directory of Open Access Journals (Sweden)

    Alejandro Uribe Tirado

    2011-12-01

    Full Text Available Objetivo. Identificar desde la información disponible en los sitios Web de las bibliotecas de las universidades/instituciones de enseñanza superior (IES del Perú, los niveles de incorporación que estaría teniendo la alfabetización informacional (ALFIN como servicio fundamental y transversal de toda biblioteca en el siglo XXI. Método. Partiendo de los postulados del análisis de contenidos Web, se realiza un proceso investigativo registrando la información recopilada, en primer lugar, en una ficha de contenidos, y posteriormente, en una base de datos que permite realizar el análisis comparativo y la presentación gráfica de los resultados. Resultados. Se identificó que en la actualidad desde la información que se presenta en los sitios Web de las universidades-IES del Perú, un porcentaje muy reducido de bibliotecas universitarias se encontrarían realizando acciones de un nivel 1 ó 2 de incorporación de ALFIN, ya que una gran mayoría se encuentra aún desarrollando programas y procesos muy enfocados a la formación de usuarios tradicional, mientras que otra gran mayoría, desafortunadamente, no presenta ninguna acción-información sobre trabajos desde la perspectiva formadora que debe tener toda biblioteca. Conclusiones. Es necesario aunar esfuerzos entre las bibliotecas de las universidades-IES peruanas para que las más adelantadas apoyen los avances de las otras bibliotecas, y así en el tema de ALFIN, poder trabajar colaborativamente en acciones de formación-autoformación, bechmarking, intercambio de recursos y objetos de aprendizaje, entre otras.

  10. Molecular and morphological characterisation of two species of the genus Ellipsomyxa Køie, 2003 (Ceratomyxidae) from the gall-bladder of Liza saliens (Risso) off Tunisian coasts of the Mediterranean.

    Science.gov (United States)

    Thabet, Aouatef; Tlig-Zouari, Sabiha; Al Omar, Suliman Y; Mansour, Lamjed

    2016-07-01

    During examination of some species of the family Mugilidae, two coelozoic myxozoans were observed in the gall-bladder of the leaping mullet, Liza saliens (Risso). Spore morphology allowed us to allocate them to the genus Ellipsomyxa Køie, 2003, one of which is described here as new. Ellipsomyxa kalthoumi n. sp. was observed forming globular pseudoplasmodia and free spores floating in the bile. Mature spores are ellipsoidal, measuring 13-21 × 10-15 (17.2 × 13.2) µm and possessing two equal spherical polar capsules, 5-6 (5.5) µm in diameter, opening subterminally in opposite directions, with nine polar filament coils. Morphological data and molecular analysis of the small subunit rDNA sequences helped identify this parasite as a new species of Elliposmyxa. The second species identified as E. mugilis (Sitjà-Bobadilla & Alvarez-Pellitero, 1993) has oval spores with rounded ends, measuring 10-11 × 7-9 (10.5 × 8.0) µm and possessing two polar subspherical capsules, 2.7-3.0 (2.8) µm in diameter, opening subterminally in opposite directions. Spore morphometry and molecular study of the small subunit (SSU) of the rRNA gene identified this species as E. mugilis described from the same host in the Western Mediterranean off Spain. Phylogenetic analysis revealed Elliposmyxa as a monophyletic clade and showed that E. mugilis, E. syngnathi Køie & Karlsbakk, 2009, E. adlardi Whipps & Font, 2012 and E. gobii Køie, 2003 group in a subclade containing the Tunisian isolate of E. mugilis whereas E. kalthoumi n. sp. appears in a second subclade together with four Australian species, E. maniliensis Heiniger & Adlard, 2014, E. apogoni Heiniger & Adlard, 2014, E. nigropunctatis Heiniger & Adlard, 2014 and E. arothroni Heiniger & Adlard, 2014.

  11. Talleres artístico-pedagógicos para promover habilidades mediadoras, que favorezcan la resolución pacífica de conflictos escolares, en los estudiantes del grado cuarto del colegio Ciudadela Educativa de Bosa IED

    OpenAIRE

    Nieto Hernández, Sandra Yisella; Velandia Mikán, Lilian Astrid

    2016-01-01

    La investigación que se presenta a continuación se titula Talleres artístico pedagógicos para promover habilidades mediadoras, que favorezcan la resolución pacífica de conflictos escolares, en los estudiantes del grado cuarto del colegio Ciudadela Educativa de Bosa Institución Educativa Distrital (IED). Inició del interés por contribuir, desde una mirada pedagógica, a la problemática relacionada con la solución inadecuada de los conflictos escolares; en donde, se diseñaron ...

  12. La Desnutrición, Malnutrición y el Rendimiento Académico de los Estudiantes del sexto grado de Educación Primaria de I.E.2028 Cerro Candela, SM.P. Lima, 2007

    OpenAIRE

    Zagastizabal Gamarra, Zaira Ruth

    2015-01-01

    Sabemos que la Fuente de la Vida de todo ser humano es la alimentación y el hombre sin alimento no puede sobrevivir por lo que; viendo los problemas de salud de los estudiantes desarrollé esta investigación titulada “La Desnutrición, mal nutrición y el rendimiento académico de los estudiantes del sexto grado de Educación Primaria de la I.E.2028 Cerro Candela, SMP. Lima, 2007”, siendo la muestra de 49 estudiantes. En el contenido de esta tesis se encuentra un conjunto de ante...

  13. Estrategia Metacognitiva y la Competencia de aprender a aprender en estudiantes del primer grado de secundaria de la I.E. “Mercedes Cabello de Carbonera” – Lima, 2014

    OpenAIRE

    Reategui De Souza, Rosa Guillermina

    2014-01-01

    El presente trabajo de investigación, tuvo por objetivo Determinar la relación entre la Estrategia metacognitiva y la Competencia de Aprender a aprender en Estudiantes del primer grado de secundaria de la I.E. “Mercedes Cabello de Carbonera”. Lima - 201 4. La investigación es cuantitativa no experimental, se realizó un estudio transeccional descriptivo correlacional. La muestra es probabilística aleatoria simple, con una población de 245 estudiantes, quedando finalmente una ...

  14. Influencia de un programa de educación sexual en el desarrollo de la conducta sexual en adolescentes del cuarto año de secundaria de la IE Federico Villarreal Túcume 2015.

    OpenAIRE

    Musayón Ursina, Mariela.

    2015-01-01

    Los adolescentes viven en un riesgo social ya que no cuentan con una Educación Sexual progresiva y adecuada a su sexualidad en el aspecto biológico, afectivo, social y espiritual que le permita una conducta sexual equilibrada con el otro sexo y su realización plena como ser humano. El trabajo de Investigación desarrollado es: "la Aplicación de un Programa de Educación Sexual favorece el desarrollo de la Conducta Sexual en Adolescentes del cuarto grado de secundaria de la IE Federico Villarrea...

  15. CONTRACTUL DE VÂNZARE–CUMPĂRARE LA LICITAŢIE, ANALIZA JURIDICĂ A LEGISLAŢIEI NAŢIONALE ŞI INTERNAŢONALE ŞI ACCEPŢIUNILE JURIDICE ALE ACESTUIA

    Directory of Open Access Journals (Sweden)

    Petru Vîrlan

    2016-11-01

    Full Text Available Astăzi vânzarea la licitaţie este foarte des întâlnită în tot mai multe domenii, mai ales în mediul afacerilor, care este unul dinamic, necesită o permanentă dezvoltare şi efectuarea de tranzacţii cât mai eficiente şi în condiţii cât mai avan­ta­joase. Acest tip de vânzare are o istorie de dezvoltare destul de lungă, pe parcursul căreia respectiva instituţie a evoluat tot mai mult, astăzi având numeroase modalităţi şi reguli în acest sens.CONTRACT AUCTION SALE, NATIONAL AND INTERNATONAL LEGAL ANALYSIS AND ITS LEGAL ACCEPTANCEToday we see that auctioning is very common in more and more fields, especially in the business environment is very dynamic and requires a permanent development and trazacţii making the most efficient and more profitable conditions. This stock has a fairly long history of development and along during which this institution has evolved today increasingly having numerous ways and rules in this regard.

  16. Nanoparticles and self-organisation: the emergence of hierarchical properties from the nanoparticle soup (i.e., the small is getting bigger). Concluding remarks for Faraday Discussion: Nanoparticle Synthesis and Assembly.

    Science.gov (United States)

    Schiffrin, David J

    2015-01-01

    Some four years ago, one of the participants in this Discussion (Prof. Nicholas Kotov) predicted that: "within five years we shall see multiple examples of electronic, sensor, optical and other devices utilizing self-assembled superstructures" (N. A. Kotov, J. Mater. Chem., 2011, 21, 16673-16674). Although this prediction came partially to fruition, we have witnessed an unprecedented interest in the properties of materials at the nanoscale. The point highlighted by Kotov, however, was the importance of self-assembly of structures from well characterised building blocks to yield hierarchical structures, hopefully with predictable properties, a concept that is an everyday pursuit of synthetic chemists. This Discussion has brought together researchers from a wide range of disciplines, i.e., colloid science, modelling, nanoparticle synthesis and organisation, magnetic and optical materials, and new imaging methods, within the excellent traditional Faraday Discussion format, to discuss advances in areas relevant to the main theme of the meeting.

  17. Effect of Age at Antiretroviral Therapy Initiation on Catch-Up Growth within the First 24 Months among HIV-Infected Children in the IeDEA West African Pediatric Cohort

    Science.gov (United States)

    Jesson, Julie; Koumakpaï, Sikiratou; Diagne, Ndeye R.; Amorissani-Folquet, Madeleine; Kouéta, Fla; Aka, Addi; Lawson-Evi, Koko; Dicko, Fatoumata; Kouakou, Kouadio; Pety, Touré; Renner, Lorna; Eboua, Tanoh; Coffie, Patrick A.; Desmonde, Sophie; Leroy, Valériane

    2015-01-01

    Background We described malnutrition and the effect of age at antiretroviral therapy (ART) initiation on catch-up growth over 24 months among HIV-infected children enrolled in the IeDEA West African paediatric cohort (pWADA). Methods Malnutrition was defined at ART initiation (baseline) by a Z-score malnutrition at ART initiation, ART regimen, time period and country, were compared by age at ART initiation. Cox proportional hazards regression models determined predictors of catch-up growth on ART over 24 months. Results Between 2001 and 2012, 2004 HIV-infected children Malnutrition among these children is an additional burden that has to be urgently managed. Despite a significant growth improvement after 24 months on ART, especially in children <5 years, a substantial proportion of children still never achieved catch-up growth. Nutritional care should be part of the global healthcare of HIV-infected children in sub-Saharan Africa. PMID:25955835

  18. SPECIFICUL ACTIVITĂŢII SPECIALE DE INVESTIGAŢIE ŞI ACŢIUNII DE URMĂRIRE PENALĂ ÎNTREPRINSE PENTRU ADMINISTRAREA PROBELOR LA CERCETAREA CRIMELOR CIBERNETICE

    OpenAIRE

    Svetlana PURICI

    2016-01-01

    Importanţa investigării „criminalităţii informatice” este dictată nu doar de progresul tehnic, dar în special de prezenta bază normativă în reglementările internaţionale şi în legile naţionale ale Republicii Moldova, precum: Legea cu privire la informatică, Legea privind accesul la informaţie etc., reguli ce trebuie aplicate şi care se vor reflecta în viaţa noastră, în special în procesul de apărare a drepturilor în judecată – moment în care importanţa şi influenţa „investigării crimina­lităţ...

  19. Relevância da estratégia de coopetição para as IES: o posicionamento do Centro Universitário Católico de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Jorge Gaio

    2012-08-01

    Full Text Available The competition from consolidators in the educational market has intensified in the national and regional markets, such as Santa Catarina State, pressing the small and medium size IES to establish strategies of competition, cooperation and coopetition. The purpose of this position paper is to present the structured strategies for service excellence (KANO, 1984 and strategies coopetition (BRANDENBURGER and NALEBUFF, 1996; DAGNINO; PADULA, 2002 used by Centro Universitário Católico de Santa Catarina, established in Joinville since 2009. The literature review covered the main strategies of competition, cooperation, coopetition and the Kano (1984 matrix. It was presented the most relevant strategies under the Kano (1984 model and the coopetition strategies used by Centro Universitário Católico de Santa Catarina. The results of this research indicate the coopetition strategic position between the actors involved in higher education in the region, despite having a different set of strategies in its entrance position.

  20. A mixed methods protocol to evaluate the effect and cost-effectiveness of an Integrated electronic Diagnosis Approach (IeDA) for the management of childhood illnesses at primary health facilities in Burkina Faso.

    Science.gov (United States)

    Blanchet, Karl; Lewis, James J; Pozo-Martin, Francisco; Satouro, Arsene; Somda, Serge; Ilboudo, Patrick; Sarrassat, Sophie; Cousens, Simon

    2016-08-04

    Burkina Faso introduced the Integrated Management of Childhood Illnesses (IMCI) strategy in 2003. However, an evaluation conducted in 2013 found that only 28 % of children were assessed for three danger signs as recommended by IMCI, and only 15 % of children were correctly classified. About 30 % of children were correctly prescribed with an antibiotic for suspected pneumonia or oral rehydration salts (ORS) for diarrhoea, and 40 % were correctly referred. Recent advances in information and communication technologies (ICT) and use of electronic clinical protocols hold the potential to transform healthcare delivery in low-income countries. However, no evidence is available on the effect of ICT on adherence to IMCI. This paper describes the research protocol of a mixed methods study that aims to measure the effect of the Integrated electronic Diagnosis Approach innovation (an electronic IMCI protocol provided to nurses) in two regions of Burkina Faso. The study combines a stepped-wedge trial, a realistic evaluation and an economic study in order to capture the effect of the innovation after its introduction on the level of adherence, cost and acceptability. The main challenge is to interconnect the three substudies. In integrating outcome, process and cost data, we focus on three key questions: (i) How does the effectiveness and the cost of the intervention vary by type of health worker and type of health centre? (ii) What is the impact of changes in the content, coverage and quality of the IeDA intervention on adherence and cost-effectiveness? (iii) What mechanisms of change (including costs) might explain the relationship between the IeDA intervention and adherence? Clinicaltrials.gov, NCT02341469 .

  1. Ensino do empreendedorismo sob a ótica de alunos e professores do curso de administração de uma instituição de ensino superior (IES privada em Minas Gerais

    Directory of Open Access Journals (Sweden)

    Solange Carvalho Moreira Rodrigues

    2014-05-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2014v7n2p198 Este artigo objetiva verificar a prática didático-pedagógica na área do empreendedorismo e sua interferência na propensão às atividades empreendedoras na percepção de alunos e professores do curso de Administração de uma Instituição de Ensino Superior (IES privada localizada no Vale do Aço-MG. Este estudo de caso qualitativo descritivo teve como sujeitos de pesquisa quinze alunos do oitavo período do curso de Administração e quatro professores do referido curso, definidos por acessibilidade. Os dados foram coletados por meio de entrevistas semiestruturadas e análise documental. Posteriormente, foram ordenados, tabulados e classificados em unidades temáticas buscando-se os significados e a essência nos relatos. Evidenciou-se que a prática didático-pedagógica adotada na IES pesquisada propicia aos estudantes condições ao processo de empreender indicando a possibilidade de ensino formal do empreendedorismo. Como um fenômeno “multifacetado e multidisciplinar” demonstra não ser excludente uma via ou outra de aprendizado, exigindo no ambiente escolar, atividades práticas como nos moldes da Empresa-Ação ou de empresas simuladas. Do ponto de vista institucional destacam-se algumas contribuições para o campo como a adoção de mecanismos de apoio ao ensino, a realização de parcerias entre os atores institucionais privados e públicos, empresas de transferência de tecnologia ofertando condições estruturais, além das incubadoras.

  2. Trabalho e estresse: identificação do estresse e dos estressores ocupacionais em trabalhadores de uma unidade administrativa de uma Instituição Pública de Ensino Superior (IES

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    Edward Goulart Junior

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2014v7n1p1 O artigo apresenta pesquisa realizada junto a servidores públicos de uma Instituição de Ensino Superior (IES que teve como objetivo diagnosticar a presença do estresse nessa população, a fase do estresse em que os indivíduos se encontram e a predominância de sintomas, se físicos ou psicológicos. Objetivou também caracterizar o quadro sintomatológico da população que experimenta estresse e os principais estressores do contexto de trabalho onde os participantes atuam. A pesquisa revelou que 46,6% dos participantes estão experimentando estresse, a sua maioria se encontra em fase de resistência com predominância de sintomas psicológicos. Entre os principais estressores dos contextos de trabalho, destacaram-se o ambiente físico do local de trabalho, infraestrutura do setor de trabalho, processo de avaliação de desempenho profissional adotado pela IES, baixo reconhecimento atribuído ao  trabalho realizado e o número reduzido de servidores em determinados setores. Os resultados revelaram a avanço da presença do estresse nessa amostra e a necessidade de ações adequadas de políticas e práticas de gestão de pessoas que visem atuar para minimizar esse fenômeno.

  3. Institutional participative strategic planning method for community higher education institution (HEI Planejamento estratégico participativo em uma instituição de ensino superior (IES comunitária

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    Marcus Vinicius Anátocles Ferreira

    2010-10-01

    Full Text Available This article proposes a method for the participation of university managers and stakeholders in the validation of the questions and strategy choice during the Strategic Planning process in a Community HEI. It proposes a tool for participations that considers an evolutionary and systemic vision in the proposition. It preserves the HEI community characteristics. The use of interviews, meetings, seminars and works with the community members envolved through working g roups and committees, is a way to legitimate the results and to achieve a integrated strategic planning.Este artigo propõe uma metodologia de participação da comunidade de gestores universitários e stakeholders para validação das questões e determinação das estratégias no processo de Planejamento Estratégico em IES comunitária. Propõe ainda um mecanismo de participação que considera uma visão sistêmica e evolutiva na proposição, estruturação e no processo de operacionalização do planejamento estratégico, preservando as características das comunidades das IES. A utilização de entrevistas, reuniões, seminários e trabalhos com membros das comunidades envolvidas através de grupos de trabalho e comitês, servem como forma de legitimação dos resultados e para realizar um pensamento estratégico integrado.

  4. Comparative study on the composition of free amino acids and derivatives in the two botanical origins of an edible Chinese herb "Xiebai", i.e., Allium chinense G. Don and Allium macrostemon Bunge species.

    Science.gov (United States)

    He, Quan; Huang, Shaohui; Wu, Yuehong; Zhang, Wenqi; Wang, Fanchao; Cao, Jiawei; Sheng, Qing; Liang, Zongsuo; Liu, Lili; Ou, Wen-Bin

    2018-04-01

    Xiebai is an edible Chinese herb with various health and therapeutic benefits. To evaluate its nutritional and health values, the free amino acids and derivatives of its two botanical origins (i.e., Allium chinense G. Don and Allium macrostemon Bunge) were isolated using a solvent extraction method and analyzed using automatic amino acid analysis and ultra-performance liquid chromatography-quadrupole-time of flight (UPLC-Q-TOF) mass spectrometry. Our data show that both plants contain abundant free amino acids, and the amount of total free amino acids in A. chinense G. Don is higher than that in A. macrostemon Bunge. The free amino acid compositions in the two plants are qualitatively similar, including nineteen proteinogenic and four non-proteinogenic amino acids. The identified proteinogenic amino acids include eight essential amino acids and five semi-essential amino acids. The sum of essential and semi-essential amino acids accounts for 64.9% and 69.7% of the total free amino acids of the two plants, respectively. The principal amino acids of both plants, from highest concentration to lowest concentration, are arginine, glutamine, glutamic acid, asparagine and serine. A. chinense G. Don is also rich in citrulline and lysine. In addition, two amino acid derivatives were identified from the two plants, i.e., the proline analog N‑methyl‑proline and the dipeptide H-Glu-Tyr-OH. For the first time, the presence of N‑methyl‑proline in the plants of the Allium genus and the presence of H-Glu-Tyr-OH in unprocessed food sources are reported. The influences of the identified substances on the flavor, nutrition and health values of Xiebai are discussed. Copyright © 2018 Elsevier Ltd. All rights reserved.

  5. A necessidade da informação gerencial nas IES públicas da Europa: breve abordagem pela realidade de Portugal = The need of managing information in European public universities: a brief approach to the Portuguese reality

    Directory of Open Access Journals (Sweden)

    Renato Pereira Monteiro

    2015-08-01

    Full Text Available O objetivo deste estudo é analisar a importância da informação gerencial por Instituições de Ensino Superior Públicas europeias com ênfase no contexto de Portugal. O cenário de crise financeira pela qual passa o setor público de Portugal nos últimos anos é notório, incidindo em cortes salariais e também na redução do número de oferta de vagas no ensino superior público constituído de universidades e institutos politécnicos. Portanto, é de grande relevância discutir como a contabilidade de custos por meio de informações gerenciais pode apoiar a gestão das Instituições de Ensino Superior (IES. Realizou-se uma ampla pesquisa bibliográfica que permitiu descrever quais as principais funcionalidades da informação de custos como apoiadora do processo de decisão em IES. As vantagens informacionais encontradas remetem essencialmente ao aumento da eficiência e eficácia governamental por meio de planejamento mais adequado, construção de indicadores de desempenho, alternativas para a redução de custos, possibilidade de comparações e aumento da transparência para o controle social.The aim of this study is to analyze the importance of managing information in High Education Institutions - Public High Education Institutions, focusing on the Portuguese context. The scenery of financial crisis that crosses over the Portuguese public sector over the past few years is eye-catching. Salary cuts and the decrease on the number of vacancies in public high education institutions has been a major concern. Therefore, it is of high importance to analyze to what extend the cost accountancy by the means of managing information can support the management of high education institutions. It was taken a bibliographic research which allowed depicting the main functions of the cost information as a support to the decision making process in the High Education Institutions. The explanatory advantages which were found in this study lead us

  6. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

    Science.gov (United States)

    Ekouevi, Didier K; Balestre, Eric; Coffie, Patrick A; Minta, Daouda; Messou, Eugene; Sawadogo, Adrien; Minga, Albert; Sow, Papa Salif; Bissagnene, Emmanuel; Eholie, Serge P; Gottlieb, Geoffrey S; Dabis, François; Zannou, Djimon Marcel; Ahouada, Carin; Akakpo, Jocelyn; Ahomadegbé, Christelle; Bashi, Jules; Gougounon-Houéto, Alice; Azon-Kouanou, Angèle; Houngbé, Fabien; Koumakpaï, Sikiratou; Alihonou, Florence; d'Almeida, Marcelline; Hodonou, Irvine; Hounhoui, Ghislaine; Sagbo, Gracien; Tossa-Bagnan, Leïla; Adjide, Herman; Drabo, Joseph; Bognounou, René; Dienderé, Arnaud; Traore, Eliezer; Zoungrana, Lassane; Zerbo, Béatrice; Sawadogo, Adrien Bruno; Zoungrana, Jacques; Héma, Arsène; Soré, Ibrahim; Bado, Guillaume; Tapsoba, Achille; Yé, Diarra; Kouéta, Fla; Ouedraogo, Sylvie; Ouédraogo, Rasmata; Hiembo, William; Gansonré, Mady; Messou, Eugène; Gnokoro, Joachim Charles; Koné, Mamadou; Kouakou, Guillaume Martial; Bosse, Clarisse Amani; Brou, Kouakou; Assi, Achi Isidore; Chenal, Henri; Hawerlander, Denise; Soppi, Franck; Minga, Albert; Abo, Yao; Bomisso, Germain; Eholié, Serge Paul; Amego, Mensah Deborah Noelly; Andavi, Viviane; Diallo, Zelica; Ello, Frédéric; Tanon, Aristophane Koffi; Koule, Serge Olivier; Anzan, Koffi Charles; Guehi, Calixte; Aka, Edmond Addi; Issouf, Koffi Ladji; Kouakou, Jean-Claude; N'gbeche, Marie-Sylvie; Touré, Pety; Avit-Edi, Divine; Kouakou, Kouadio; Moh, Magloire; Yao, Valérie Andoblé; Folquet, Madeleine Amorissani; Dainguy, Marie-Evelyne; Kouakou, Cyrille; Méa-Assande, Véronique Tanoh; Oka-Berete, Gladys; Zobo, Nathalie; Acquah, Patrick; Kokora, Marie-Berthe; Eboua, Tanoh François; Timité-Konan, Marguerite; Ahoussou, Lucrèce Diecket; Assouan, Julie Kebé; Sami, Mabéa Flora; Kouadio, Clémence; Renner, Lorna; Goka, Bamenla; Welbeck, Jennifer; Sackey, Adziri; Owiafe, Seth Ntiri; Wejse, Christian; Silva, Zacarias José Da; Paulo, Joao; Rodrigues, Amabelia; da Silva, David; Medina, Candida; Oliviera-Souto, Ines; Ostergaard, Lars; Laursen, Alex; Sodemann, Morten; Aaby, Peter; Fomsgaard, Anders; Erikstrup, Christian; Eugen-Olsen, Jesper; Maïga, Moussa Y; Diakité, Fatoumata Fofana; Kalle, Abdoulaye; Katile, Drissa; Traore, Hamar Alassane; Minta, Daouda; Cissé, Tidiani; Dembelé, Mamadou; Doumbia, Mohammed; Fomba, Mahamadou; Kaya, Assétou Soukho; Traoré, Abdoulaye M; Traoré, Hamady; Toure, Amadou Abathina; Dicko, Fatoumata; Sylla, Mariam; Berthé, Alima; Traoré, Hadizatou Coulibaly; Koïta, Anta; Koné, Niaboula; N'diaye, Clémentine; Coulibaly, Safiatou Touré; Traoré, Mamadou; Traoré, Naïchata; Charurat, Man; Ajayi, Samuel; Dapiap, Stephen; Otu; Igbinoba, Festus; Benson, Okwara; Adebamowo, Clément; James, Jesse; Obaseki; Osakede, Philip; Olasode, John; Sow, Papa Salif; Diop, Bernard; Manga, Noël Magloire; Tine, Judicael Malick; Signate Sy, Haby; Ba, Abou; Diagne, Aida; Dior, Hélène; Faye, Malick; Gueye, Ramatoulaye Diagne; Mbaye, Aminata Diack; Patassi, Akessiwe; Kotosso, Awèrou; Kariyare, Benjamin Goilibe; Gbadamassi, Gafarou; Komi, Agbo; Mensah-Zukong, Kankoé Edem; Pakpame, Pinuwe; Lawson-Evi, Annette Koko; Atakouma, Yawo; Takassi, Elom; Djeha, Améyo; Ephoévi-Gah, Ayoko; Djibril, Sherifa El-Hadj; Dabis, François; Bissagnene, Emmanuel; Arrivé, Elise; Coffie, Patrick; Ekouevi, Didier; Jaquet, Antoine; Leroy, Valériane; Lewden, Charlotte; Sasco, Annie; Azani, Jean-Claude; Allou, Gérard; Balestre, Eric; Bohossou, Franck; Karcher, Sophie; Gonsan, Jules Mahan; Carrou, Jérôme Le; Lenaud, Séverin; Nchot, Célestin; Malateste, Karen; Yao, Amon Roseamonde; Siloué, Bertine; Clouet, Gwenaelle; Djetouan, Hugues; Doring, Alexandra; Kouakou, Adrienne; Rabourdin, Elodie; Rivenc, Jean; Anglaret, Xavier; Ba, Boubacar; Essanin, Jean Bosco; Ciaranello, Andrea; Datté, Sébastien; Desmonde, Sophie; Diby, Jean-Serge Elvis; Gottlieb, Geoffrey S; Horo, Apollinaire Gninlgninrin; Kangah, Serge N'zoré; Malvy, Denis; Meless, David; Mounkaila-Harouna, Aida; Ndondoki, Camille; Shiboski, Caroline; Thiébaut, Rodolphe; Pac-Ci; Abidjan

    2013-01-01

    HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region. Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3). This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.

  7. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

    Directory of Open Access Journals (Sweden)

    Didier K Ekouevi

    Full Text Available HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA.We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region.Data was merged for 1,754 patients (56% female, including 1,021 HIV-2 infected patients (551 on ART and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART. At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7 and 42.4 years, IQR (37.0-47.3 for dually seropositive patients (p = 0.048. Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C. The median CD4 count at the ART initiation is 166 cells/mm(3, IQR (83-247 among HIV-2 infected patients and 146 cells/mm(3, IQR (55-249 among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3 after 24 months on ART for HIV-2 patients and 169 cells/mm(3 for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3.This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.

  8. Desafios da gestão em instituições de ensino superior: um estudo de caso a partir da percepção de diretores de centro de uma IES pública do sul do Brasil

    Directory of Open Access Journals (Sweden)

    Leomar dos Santos

    2013-01-01

    Full Text Available This research aimed to analyze the management challenges from the perception of Center Directors of a higher education institution (IES in the South of Brazil with regard to knowledge; evaluations of others; time available; commitment of subordinates; management of differences; bureaucracy and centralization; and ethical actions. A qualitative case study with data collection by means of in-depth interviews with seven Center Directors from a screenplay with open questions, whose answers underwent content analysis. The main challenges faced by the directors of the Center are related to the absence of prior knowledge about the function and management aspects; the time available for the position in relation to the activities that need to be carried out; and management of relational differences of subordinates, administrative and personal. It is hoped that this study can contribute to the University Management to point out some of the challenges faced by University managers in the exercise of its function, helping them improve their processes of preparation, as well as assist the HIES in the monitoring of these professionals. In addition, it is believed that it can contribute to the area of knowledge to identify different challenges and, therefore, different possibilities of research topics in university management.

  9. CONSCIÊNCIA AMBIENTAL, HÁBITOS DE CONSUMO SUSTENTÁVEL E INTENÇÃO DE COMPRA DE PRODUTOS ECOLÓGICOS DE ALUNOS DE UMA IES DE SANTA CATARINA

    Directory of Open Access Journals (Sweden)

    Silvana Silva Vieira Tambosi

    2014-12-01

    Full Text Available O objetivo deste estudo é mensurar três importantes variáveis de sustentabilidade: consciência ambiental, hábitos de consumo sustentável e intenção de comprar produtos ecológicos. Para isso, realizou-se uma pesquisa quantitativa e descritiva com 182 estudantes de uma IES do Estado de Santa Catarina. Por meio de análise de médias, testeT, ANOVA e regressão, percebeu-se que os alunos possuem consciência ambiental. Verificou-se ainda, que com o avanço da idade, as pessoas tendem a possuir com mais intensidade hábitos de consumir produtos sustentáveis e maior intenção de comprar produtos ecológicos. Outra característica pessoal que apresentou diferença estatística foi o tipo de curso, neste caso, observa-se que alunos de pedagogia possuem hábitos de consumo sustentável mais intenso. Dentre as questões investigadas, as que demonstraram maior concordância foram: a humanidade está abusando seriamente do meio ambiente; e, os seres humanos devem viver em harmonia com a natureza para que possam sobreviver melhor

  10. Laboratory-Scale Column Testing Using IONSIV IE-911 for Removing Cesium from Acidic Tank Waste Simulant. 2: Determination of Cesium Exchange Capacity and Effective Mass Transfer Coefficient from a 500-cm3 Column Experiment

    International Nuclear Information System (INIS)

    T.J. Tranter; R.D. Tillotson; T.A. Todd

    2005-01-01

    A semi-scale column test was performed using a commercial form of crystalline silicotitanate (CST) for removing radio-cesium from a surrogate acidic tank solution, which represents liquid waste stored at the Idaho National Engineering and Environmental Laboratory (INEEL). The engineered form of CST ion exchanger, known as IONSIVtmIE-911 (UOP, Mt. Laurel, NJ, USA), was tested in a 500-cm3 column to obtain a cesium breakthrough curve. The cesium exchange capacity of this column matched that obtained from previous testing with a 15-mc3 column. A numerical algorithm using implicit finite difference approximations was developed to solve the governing mass transport equations for the CST columns. An effective mass transfer coefficient was derived from solving these equations for previously reported 15 cm3 tests. The effective mass transfer coefficient was then used to predict the cesium breakthrough curve for the 500-cm3 column and compared to the experimental data reported in this paper. The calculated breakthrough curve showed excellent agreement with the data from the 500-cm3 column even though the interstitial velocity was a factor of two greater. Thus, this approach should provide a reasonable method for scale up to larger columns for treating actual tank waste

  11. A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., "weaving") while driving at a blood alcohol concentration of 0.5 g/L.

    Science.gov (United States)

    Jongen, S; Vermeeren, A; van der Sluiszen, N N J J M; Schumacher, M B; Theunissen, E L; Kuypers, K P C; Vuurman, E F P M; Ramaekers, J G

    2017-03-01

    The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of lateral position (SDLP), a measure of road tracking error or "weaving". The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study. The present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L). Overall, mean SDLP increased with 2.5 cm (95% CI 2.0-2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP. These results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.

  12. Dāvināšana kā patērēšanas kultūras iezīme. Parfimērijas iegādes ietekmējošie faktori

    OpenAIRE

    Liepiņa, Krista

    2016-01-01

    Bakalaura darba “Dāvināšana kā patērēšanas kultūras iezīme. Parfimērijas iegādes ietekmējošie faktori” mērķis ir izpētīt, kas ir patērēšana un kas ietekmē patērētāju uzvedību ikdienā, kā arī svētku laikā, lēmuma pieņemšanas procesā, izvēloties preces dāvināšanas mērķim, nevis personīgai lietošanai. Darba teorētiskajā daļā apskatītas tādu jēdzienu teorētiskie aspekti kā patērēšana un patērniecība, patērēšanas kultūra, patērētāju uzvedība, patērētāju identitāte, kā arī tiek apskatīta dāvanu dāv...

  13. Personāla vadīšana Valsts ieņēmumu dienesta Rīgas muitas reģionālajā iestādē

    OpenAIRE

    Beinerte, Inga

    2009-01-01

    Lai veiksmīgi uzsāktu uzņēmuma vadīšanu ir nepieciešami noteikti resursi, uz ko balstīt uzņēmumu. Visneprognozējamākie un grūtāk vadāmie no šiem resursiem ir cilvēkresursi. Bez cilvēkresursiem nav iedomājama uzņēmējdarbība, jo tie izgudro un ražo preces, sniedz pakalpojumus, vada un kontrolē procesu darbību, kā arī kontrolē to kvalitāti. Maģistra darba „Personāla vadīšana Valsts ieņēmumu dienesta Rīgas muitas reģionālajā iestādē” mērķis ir izpētīt personāla vadību, tās būtību un izanalizē...

  14. Latvijas kā medicīnas tūrisma galamērķa konkurētspēju ietekmējošie faktori

    OpenAIRE

    Sidorenko, Anna

    2012-01-01

    Bakalaura darba temats ir «Latvijas kā medicīnas tūrisma galamērķa konkurētspēju ietekmējošie faktori». Ņemot vērā starptautisko pieredzi, medicīnas pakalpojumu sniegšana ārvalstniekiem var nodrošināt papildus ienākumu avotu nacionālajai ekonomikai. Bakalaura darba mērķis ir identificēt un izpētīt faktorus, kas ietekmē Latvijas kā medicīnas tūrisma galamērķa konkurētspēju un izstrādāt priekšlikumus medicīnas pakalpojumu sniedzējiem un valsts pārvaldes institūcijām ar nolūku veicināt Latvij...

  15. Laboratory-Scale Column Testing Using IONSIV IE-911 for Removing Cesium from Acidic Tank Waste Simulant. 1: Cesium Exchange Capacity of a 15-cm3 Column and Dynamic Stability of the Exchange Media

    International Nuclear Information System (INIS)

    T.J. Tranter; R.D. Tillotson; T.A. Todd

    2005-01-01

    Bench-scale column tests were performed using a commercial form of crystalline silicotitanate (CST) for removing radio-cesium from a surrogate acidic tank solution representative of liquid waste stored at the Idaho National Engineering and Environmental Laboratory (INEEL). An engineered form of CST ion exchanger, known as IONSIVtm IE-911 (UOP, Mt Laurel, NJ, USA), was tested in 15 cm3 columns at a flow rate of 5 bed volumes per hour. These experiments showed the ion exchange material to have reasonable selectivity and capacity for removing cesium from the complex chemical matrix of the solution. However, previous testing indicated that partial neutralization of the feed stream was necessary to increase the stability of the ion exchange media. Thus, in these studies, CST degradation was determined as a function of throughput in order to better assess the stability characteristics of the exchanger for potential future waste treatment applications. Results of these tests indicate that the degradation of the CST reaches a maximum very soon after the acidic feed is introduced to the column and then rapidly declines. Total dissolution of bed material did not exceed 3% under the experimental regime used

  16. LA UNIDAD DIDÁCTICA ORIENTADA A LA COMPRENSION DE LA IRRITABILIDAD COMO PATRON COMUN A TODOS LOS ORGANISMOS PARA FORTALECER LAS RELACIONES COOPERATIVAS EN LOS ESTUDIANTES DEL GRADO 902 DEL IED COLEGIO KIMY PERNIA DOMICO

    Directory of Open Access Journals (Sweden)

    Dennys Eliana Rodríguez Chiguasuque

    2015-12-01

    Full Text Available Se presenta la propuesta del diseño de una unidad didáctica que se realizó en el eje dinámica y mantenimiento de los sistemas de la Licenciatura en Biología de la Universidad Pedagógica Nacional, en donde se plantea el diseño de una unidad didáctica orientada a la comprensión de la irritabilidad como patrón común a todos los organismos, permitiendo fortalecer las relaciones cooperativas en los estudiantes del grado 902 del IED Colegio Kimy Pernía Domicó, ubicado en el barrio Bosa de la ciudad de Bogotá. En la cual, además del contenido temático, contemplara también un enfoque humanístico, crítico y reflexivo que les permitiera no solo el aprendizaje del patrón, sino la aplicabilidad del mismo en contexto; tomando la “educación problematizadora”. Por último se puede evidenciar que la unidad didáctica es de gran importancia para el proceso de enseñanza aprendizaje, además de ello le permite al maestro obtener habilidades en la planeación y planteamiento de actividades, lo que es de gran aporte para su formación profesional.

  17. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients.

    Science.gov (United States)

    Wang, Liang; Xia, Zhong-jun; Huang, Hui-qiang; Lu, Yue; Zhang, Yu-jing

    2012-11-01

    We conducted a retrospective study of 135 patients of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL) treated with CHOP as induction chemotherapy to find some valuable prognostic factors and analyze the usefulness of International Prognostic Index (IPI) and Korean Prognostic Index (KPI) in predicting prognosis. Most of the patients were in the low-risk group (IPI score 0-1). Complete remission (CR) after induction chemotherapy was achieved in 31.8 % of the patients, which increased to 69.6 % after radiotherapy. The 2-, 5-, and 10-year overall survival (OS) rates were 60, 48, and 43 %, respectively. Patients with better performance status (ECOG 0-1), normal serum LDH level, without local invasiveness, low KPI scores, and IPI score of 0 had significantly better overall survival (P KPI score systems should be improved further to classify patients into different groups, and should be validated in larger prospective trials. Due to the multi-drug resistance mechanism of ENKTL, CHOP is no longer the state of art and novel drugs should be incorporated into future treatments.

  18. 基于解释结构模型的IE专业本科毕业设计考评体系研究%Research on Evaluation System of IE Professional Undergraduate Graduation Design Based on Interpretative Structure Modeling

    Institute of Scientific and Technical Information of China (English)

    刘冠权; 谢亚雯; 陈艳

    2018-01-01

    Graduation design is a key practical step for student to consolidate profesional knowledge and enhance the comprehensive ability. But in practice, the essential procedural and comprehensive characteristics of graduation design are ignored. Based on the evaluation index system of the applied IE professional graduation design by using the method of Interpretative Structual Modeling (ISM) , and using the Analytic Hierarchy process (AHP) to determine the weight of all sections of graduation. An evaluation system has been built which covers the comprehensive assessment of whole process. Evaluation system makes the defense results more fair and reliable, so as to improve the quality of graduation design fundamentally.%本科毕业设计作为学生巩固专业知识和提升综合能力的关键实践环节,但在实践中,却忽视了毕业设计的过程特性和综合特性.运用解释结构模型的方法构建应用型IE专业本科毕业设计评价指标体系的基础上,采用层次分析法确定了毕业设计各个环节的权重,构建了对全过程进行综合考核的评价体系,使得答辩成绩更加公平可靠,从而从根本上提升毕业设计的质量.

  19. Electronic properties and bulk moduli of new boron nitride polymorphs, i.e., hyperdiamond B12N12 and simple cubic B24N24, B12N12 fulborenites

    International Nuclear Information System (INIS)

    Pokropivny, V. V.; Bekenev, V. L.

    2006-01-01

    The energy-band structure, density of states, electron density distribution, equation of state, and bulk moduli of three boron-nitride fulborenite crystals, i.e., B 12 N 12 with diamond lattice and B 24 N 24 , B 12 N 12 with simple cubic lattice, whose sites contain fulborene B 12 N 12 and B 24 N 24 molecules, are calculated for the first time using the full-potential linearized augmented plane wave method. The following hyperdiamond B 12 N 12 parameters were obtained: the equilibrium lattice parameter a = 1.1191 nm, the B-N bond length a BN = 0.1405 nm, the number of atoms per unit cell Z = 192, the density ρ = 2.823 g/cm 3 , the bulk modulus B 0 = 658 GPa, and the band gap ΔE g = 3.05 eV. This is a previously unknown unique light superhard semiconductor faujasite with a recorded bulk modulus higher than that of diamond. There are reasons to assume that it is a E phase. The characteristics of B 24 N 24 with simple cubic lattice are as follows: the equilibrium lattice parameter a = 0.7346 nm, the B-N bond length a BN = 0.1521 nm, the number of atoms per unit cell Z = 48, the density ρ = 2.495 g/cm 3 , the bulk modulus B 0 = 367 GPa, and the band gap ΔE g = 3.76 eV. This material is a heteropolar semiconductor or insulator with a bulk modulus comparable with that of cubic boron nitride, as well as a new boron-nitride zeolite with channel diameter of 0.46 nm. B 12 N 12 with simple cubic lattice is a molecular semimetal

  20. A Influência do Marketing Verde nos Hábitos de Consumo dos Jovens Universitários dos Cursos de Administração: Estudo em Instituições de Ensino Superior (IES

    Directory of Open Access Journals (Sweden)

    Rejane Alexandrina Domingues Pereira Prado

    2011-12-01

    Full Text Available Impactos negativos decorrentes de atividades mercadológicas e industriais sustentadoras das sociedades capitalistas estão explícitos no meio ambiente trazendo conseqüências como a poluição, acúmulo de resíduos e destruição da fauna e flora, entre outras. Decorrente dessa constatação, um número cada vez maior de indivíduos percebe que são parte ativa do processo de destruição do meio ambiente, e que seus atos tanto podem contribuir para agravar como para melhorar tal situação. Considerando essa nova realidade, o objetivo deste estudo consiste na análise da influência do marketing verde nos hábitos de consumo dos estudantes de duas IES, no interior de Minas Gerais, para investigar se eles reconhecem a importância dessa prática e, se, enquanto futuros administradores buscariam incentivá-las em suas empresas. Foi feita uma pesquisa bibliográfica, para conceituar os temas: marketing verde, comportamento do consumidor e consumo consciente. O instrumento de pesquisa foi o questionário. Os dados coletados foram analisados usando-se o software estatístico SPSS. O estudo possibilitou inferir que há uma enorme distância entre o que os jovens pensam e suas verdadeiras ações em relação às questões ambientais. Apesar dos entrevistados reconhecerem a importância do marketing verde nas empresas, a maioria afirma não serem influenciados por esta prática, de forma que não possuem hábitos de consumo consciente. DOI: 10.5585/remark.v10i2.2217

  1. Moda De Alta Geometría”. Una Estrategia para desarrollar competencias científicas en los estudiantes del Colegio Marruecos y Molinos IED J.T. De Bogotá D.C

    Directory of Open Access Journals (Sweden)

    Mónica Andrea López Sarmiento

    2015-12-01

    Full Text Available Este trabajo es el resultado de la implementación del ambiente de aprendizaje “Moda de Alta Geometría”, ejecutado por estudiantes y maestros de grado Noveno jornada tarde, desde el evento mundialista, Brasil 2014, donde se vinculan las áreas de lengua castellana, ciencias sociales, tecnología, educación física, ciencias naturales,  educación ambiental y matemáticas, en el  colegio Marruecos y Molinos IED, localidad 18 Rafael Uribe Uribe, en la ciudad de Bogotá. El ambiente se llevó a cabo  en tres fases: diseño, implementación y socialización. Con el objetivo de desarrollar competencias científicas mediante la observación, exploración, análisis de información, y generación de estrategias para dar solución a diferentes problemáticas a partir de la construcción y presentación de un traje de fantasía a escala real, representativo de cada país participante en el evento deportivo, elaborado en las técnicas de origami. Este ambiente favoreció el trabajo colaborativo entre los estudiantes, así como el replanteamiento de las prácticas pedagógicas de los docentes vinculados al proyecto y la participación de diferentes estamentos de la comunidad educativa, como las familias, quienes estuvieron activos en el desarrollo del mismo

  2. Conhecimento e formação nas IES periféricas perfil do aluno "novo" da educação superior Knwoledge and education in the peripheral higher education institutions: profile of the "new" undergraduate student

    Directory of Open Access Journals (Sweden)

    Luiz Percival Leme Britto

    2008-11-01

    Full Text Available Considerando a forma como se organiza atualmente a Educação Superior no Brasil, num contexto de forte demanda por conhecimento de caráter instrumental e normativo, voltado para a adequação dos sujeitos, de suas condutas e avaliações às exigências da produção e do consumo urbanos, busca-se avançar o reconhecimento das concepções de conhecimento e de desenvolvimento pessoal do estudante universitário. Para tanto, apresentamos neste trabalho uma análise do campo da Educação Superior no Brasil atual, com ênfase na identificação caracterização de IES periférica e do aluno "novo". Este trabalho apresenta resultados parciais de pesquisa que vem sendo realizadas em torno do tema "Educação superior, cultura escrita e conhecimento".Considering the way in which Higher Education is presently structured in Brazil, in a context characterized by strong demands for normative and instrumental knowledge, aiming to adjust the conducts and evaluations of the subjects to the demands of the market-place, this study seeks the advance of the analysis of the concepts of knowledge and personal development of the university student. We present in this paper an analysis of Higher Education in Brazil, emphasizing the characterization and identification of the peripheral Higher Education Institutions and the "new" student. This work presents partial results of a research that is being done on the theme "Higher Education, Literacy and knowledge".

  3. 12-month mortality and loss-to-program in antiretroviral-treated children: The IeDEA pediatric West African Database to evaluate AIDS (pWADA, 2000-2008

    Directory of Open Access Journals (Sweden)

    Peterson Kevin

    2011-06-01

    Full Text Available Abstract Background The IeDEA West Africa Pediatric Working Group (pWADA was established in January 2007 to study the care and treatment of HIV-infected children in this region. We describe here the characteristics at antiretroviral treatment (ART initiation and study the 12-month mortality and loss-to-program of HIV-infected children followed in ART programs in West Africa. Methods Standardized data from HIV-infected children followed-up in ART programs were included. Nine clinical centers from six countries contributed to the dataset (Benin, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal. Inclusion criteria were the followings: age 0-15 years and initiated triple antiretroviral drug regimens. Baseline time was the date of ART initiation. WHO criteria was used to define severe immunosuppression based on CD4 count by age or CD4 percent 6 months after ART initiation and factors associated with these two outcomes. Results Between June 2000 and December 2007, 2170 children were included. Characteristics at ART initiation were the following: median age of 5 years (Interquartile range (IQR: 2-9 and median CD4 percentage of 13% (IQR: 7-19. The most frequent drug regimen consisted of two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitors (62%. During the first 12 months, 169 (7.8% children died and 461(21.2% were lost-to-program. Overall, in HIV-infected children on ART, the 12-month probability of death was 8.3% (95% Confidence Interval (CI: 7.2-9.6%, and of loss-to-program was 23.1% (95% CI: 21.3-25.0%. Both mortality and loss-to program were associated with advanced clinical stage, CD4 percentage 2005 of ART initiation. Conclusion Innovative and sustainable approaches are needed to better document causes of death and increase retention in HIV pediatric clinics in West Africa.

  4. Relevância da estratégia de coopetição para as IES: o posicionamento do Centro Universitário Católico de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Jorge Gaio

    2012-08-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2012v5n2p36   A concorrência das corporações educacionais internacionais tem ampliado a atuação no cenário nacional e em mercados regionais, como no caso do Estado de Santa Catarina, pressionando as IES de pequeno e médio porte a estabelecerem estratégias de competição, de cooperação e de coopetição. O objetivo deste position paper é apresentar de maneira estruturada as estratégias de excelência dos serviços prestados (KANO, 1984 e as estratégias de coopertição (BRANDENBURGER E NALEBUFF, 1996; DAGNINO E PAULO, 2002 utilizadas pelo Centro Universitário Católico de Santa Catarina, desde 2009, por ocasião da entrada no mercado de Joinville. A revisão da literatura contemplou as principais estratégias de competição, cooperação, coopetição e a matriz de Kano (1984. Foram apresentadas as estratégias mais relevantes decorrentes do modelo de Kano (1984 e as estratégias de coopetição utilizadas pelo Centro Universitário Católico de Santa Catarina. Os resultados obtidos nesta pesquisa sinalizam que o posicionamento estratégico visa a coopetição entre os atores do ensino superior da região, apesar de apresentar um conjunto de estratégias diferenciadas desta tendência, em seu posicionamento de entrada inicial.

  5. Situação do estágio supervisionado em IES privadas da grande São Paulo Supervised period of training on the private universities of São Paulo and cities of the region

    Directory of Open Access Journals (Sweden)

    Sheila Aparecida Pereira dos Santos Silva

    2010-09-01

    Full Text Available Com o objetivo de diagnosticar a dinâmica da supervisão dos estágios em cursos de Graduação e Licenciatura em Educação Física após a publicação das Resoluções CNE/CP nº 01 e 02/2002, nº 07/2004 e nº 02/2007 e verificar sua aplicação, foram entrevistados sete docentes universitários, que orientam estágios curriculares em seis Instituições de Ensino Superior (IES privadas da Grande São Paulo. A entrevista, semi-estruturada, contou com sete questões abertas abrangendo a dinâmica dos estágios, carga horária, número de orientadores por aluno orientado, entre outros aspectos. Para o tratamento dos dados, foi utilizada a técnica de análise de conteúdo. Em todas as instituições pesquisadas o estágio é exigido a partir da metade do curso; existiam projetos de pesquisa e extensão que eram validados como horas/estágio e contemplavam uma disciplina destinada aos estágios, à exceção de uma delas. As horas de estágio a cumprir variaram entre 324 a 540 horas. Existiam diferenças significativas em relação ao número de orientandos por orientador, variando de 5 a 200 alunos por orientador. Em apenas uma IES ocorriam discussões sobre os relatórios apresentados. Percebeu-se a inexistência de uniformidade entre as instituições pesquisadas e, em algumas, a ausência de discussões a respeito dos estágios evidencia que as IES pouco se comprometem com a qualidade dessa experiência no processo de formação profissional e que, talvez, normas legais mais específicas sobre número máximo de alunos orientados por orientador pudessem colaborar para que esse problema fosse minimizadoWith the objective to make a diagnosis the dynamics of the supervision of the periods of training in courses of Graduation in Physical Education after the publication of Resolutions CNE/CP nº 01 and 02/2002, nº 07/2004 and nº 02/2007 and to verify its application, had been interviewed seven university professors, who guide curricular

  6. Metode de atracţie şi localizare a faunei utile în agrocenoza culturii de piersic ca factor biologic de control al densităţii speciilor dăunătoare

    Directory of Open Access Journals (Sweden)

    Mihai BATCO

    2016-06-01

    ădătoare benefice. Au fost stabilite etapele de aplicare oportună a mijloacelor bioraţionale pentru fauna utilă în agrocenoza de piersic în perioada de vegetaţie.

  7. Greenhouse Gas Emissions and Global Warming Potential of Traditional and Diversified Tropical Rice Rotation Systems including Impacts of Upland Crop Management Practices i.e. Mulching and Inter-crop Cultivation

    Science.gov (United States)

    Janz, Baldur; Weller, Sebastian; Kraus, David; Wassmann, Reiner; Butterbach-Bahl, Klaus; Kiese, Ralf

    2016-04-01

    Paddy rice cultivation is increasingly challenged by irrigation water scarcity, while at the same time changes in demand (e.g. changes in diets or increasing demand for biofuels) will feed back on agricultural practices. These factors are changing traditional cropping patterns from flooded double-rice systems to the introduction of well-aerated upland crop systems in the dry season. Emissions of methane (CH4) are expected to decrease, while emissions of nitrous oxide (N2O) will increase and soil organic carbon (SOC) stocks will most likely be volatilized in the form of carbon dioxide (CO2). We measured greenhouse gas (GHG) emissions at the International Rice Research Institute (IRRI) in the Philippines to provide a comparative assessment of the global warming potentials (GWP) as well as yield scaled GWPs of different crop rotations and to evaluate mitigation potentials or risks of new management practices i.e. mulching and inter-crop cultivation. New management practices of mulching and intercrop cultivation will also have the potential to change SOC dynamics, thus can play the key role in contributing to the GWP of upland cropping systems. To present, more than three years of continuous measurement data of CH4 and N2O emissions in double-rice cropping (R-R) and paddy rice rotations diversified with either maize (R-M) or aerobic rice (R-A) in upland cultivation have been collected. Introduction of upland crops in the dry season reduced irrigation water use and CH4 emissions by 66-81% and 95-99%, respectively. Moreover, for practices including upland crops, CH4 emissions in the subsequent wet season with paddy rice were reduced by 54-60%. Although annual N2O emissions increased twice- to threefold in the diversified systems, the strong reduction of CH4 led to a significantly lower (pbalance but also with regard to soil fertility. New upland crop management practices where first implemented during land-preparation for dry season (July) 2015 where i) 6t/ha rice straw

  8. Efeitos do(s letramento(s na constituição social do sujeito: considerações fonoaudiológicas Effects of Literacy (ies on the social constitution of the subject: speech therapy considerations

    Directory of Open Access Journals (Sweden)

    Natally Ribeiro

    2012-10-01

    Full Text Available OBJETIVO: caracterizar e analisar, do ponto de vista fonoaudiológico, o(s letramento(s, os modos de circulação e uso de gêneros discursivos escritos por 69 escolares de duas classes de terceiro estágio de uma escola municipal de ensino infantil da cidade de São Paulo. MÉTODO: construção e aplicação de protocolo composto por diversos gêneros discursivos escritos, para verificação do grau de reconhecimento, de familiaridade e de uso dos mesmos pelos 69 escolares pesquisados. A faixa etária dos escolares é de 5 anos e 1 mês a 6 anos e 1 mês, sendo 58% do sexo masculino e 42%, feminino. A análise dos dados foi feita a partir do mapeamento dos índices de letramento dos escolares, em função dos níveis e tipos de letramento consignados na literatura especializada. RESULTADOS: entre os gêneros discursivos escritos apresentados, foi encontrado, para essa faixa etária, um reconhecimento significante para os gêneros: carta; jornalístico; narrativas infantis; placas de trânsito; quadrinhos e receitas, sendo estes visualizados e/ou utilizados por e/ou com familiares em casa, no trajeto à escola e em outros espaços sociais. CONCLUSÃO: é considerável a presença de práticas letradas entre os pesquisados, o que sugere a relevância em se considerar os processos de letramento, tanto nas estratégias pedagógicas da educação infantil, quanto no trabalho fonoaudiológico com escolares que apresentem dificuldades e/ou distúrbios na aquisição da escrita.PURPOSE: to characterize and analyze the speech-language point o view, literacy (ies, the modes of movement and use of discursive genres written by 69 students from two classes of the third stage of an elementary public school for children of São Paulo. METHOD: the construction and application protocol consists of several written genres for checking the degree of recognition, familiarity and usage by 69 schoolchildren. The age of the students was 5 years and 1 month to 6 years

  9. POLITICA DE RECRUTARE ȘI SELECȚIE A PERSONALULUI ACADEMIC ÎN ÎNVĂȚĂMÂNTUL SUPERIOR DIN RSS MOLDOVENEASCĂ. 1944-1950

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    Liliana ROTARU

    2017-08-01

    Full Text Available Resursa umană este capitalul strategic al oricărei instituții de învățământ superior și o politică judicioasă de personal, în general, dar mai ales de recrutare și selecție a cadrelor didactico-științifice. Ea face posibilă realizarea misiunii învăță­mân­tului superior, implicit, prin cei care îl promovează. Cercetarea politicii de personal în școlile superioare din RSS Moldovenească în perioada de refacere a învățământului superior de după cel de-al Doilea Război Mondial a scos în evidență că aceasta era subordonată politicii naționale a statului sovietic, care presupunea formarea „omului nou” și integrarea acestuia în identitatea supraetnică numită „popor sovietic” – deznaționalizat, îndoctrinat cu ideologie marxist-leninistă, rusificat și rusianizat, care să aibă o patrie socialistă comună – Uniunea Sovietică și un scop comun – const­ruirea comunismului. Toate instrumentele și metodele de recrutare și selectare a personalului academic pentru insti­tuțiile de învățământ din RSS Moldovenească erau subordonate necesității creării unui corp didactico-științific în mare parte vorbitor și purtător de limbă și cultură rusă, puternic ideologizat și loial statului sovietic și partidului comunist, și mai apoi de o anumită competență profesională, toate acestea camuflate sub pregnanta idee de promovare a „elemen­tului autohton moldovenesc”.THE POLICY OF RECRUITMENT AND SELECTION OF ACADEMIC STAFF IN HIGHER EDUCATION OF MSSR. 1944-1950The human resource is the strategic capital of any higher education institutions and, in general, a judicious staff policy, but especially – a good policy of recruitment and selection of didactic and scientific staff makes possible to realize the higher education mission and, by default – the goals of those who are promoting it. The research of staff policy in high schools of MSSR during the higher education

  10. Call for Papers and Announcement Joint International Conference of Industrial Engineering and Engineering Management (IE&EM'2002)And International Conference on Electronic Commerce Engineering (ICECE'2002)%“2002年工业工程与工程管理国际会议(IE&EM’2002)”暨“2002年电子商务工程国际会议(IceCE’2002)”征文通知

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@(IE&EC'2002) 19-21 September 2002, Beijing, P. R. China Theme: Providing Comprehensive Solution to the Enterprise of Digital Economy Sponsored by * China Mechanical Engineering Society (CMES) * American Institute of Industrial Engineers * Institute of Industrial Engineers of Hong Kong * Japan Institute of Management Association * Industrial Engineering Institute of Korea * Society of Supply Chain Management, Korea * National Science Foundation of China * Institution of Electrical Engineers (IEE) Supported by * Springer-Verlag Organized by * Tsinghua University * Leeds Metropolitan University, UK * University of Science & Technology of Hong Kong * Industrial Engineering Institute, CMES * Production Engineering Institute, CMES Introduction The main theme of the conference is "Providing Comprehensive Solution to the Enterprise of Digital Economy. It aims at bringing together world-class researchers and professors in industrial engineering and e-commerce to address the major aspects such as business models, enabling technologies, engineering applications, human factor, and policy and security. The conference will focus on the emerging issues of industrial engineering and electronic commerce in the context of engineering services involving product innovation, manufacturing operations, logistics and supply chain, sales and marketing, customer services and technical supports. It is to provide a major forum for researchers and practitioners to review the past development, and to identify possible directions for further developments. The objectives of the conference 1.Establish linkages between researchers in industrial engineering and e-commerce from the perspectives of digital enterprise, as well as from different disciplines. 2.Promote a dynamic, integrative, inter-disciplinary and inter-country research agenda for e-commerce. 3.Encourage and promote the exchange between academic researchers and industrial practitioners in the field of digital enterprise. Event

  11. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  12. Regional Characteristics for Interpreting Inverted Echo Sounder (IES) observations

    Science.gov (United States)

    1987-06-01

    rounding the IESs. There are seasonal warming and and ideally, we should like to have a series of hydro- cooling effects which may be missed with...thermocline This shallo, sanabihlit\\ , Is lkck to be spatialk and temporall , aliased: it ma\\ 01 ." b assoi ated ws.ith internal \\ awes or frontal tluctua

  13. Aurel Ion Maican (II. Perioada ieşeană

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    Vera Molea

    2009-12-01

    Full Text Available Stage director Aurel Ion Maican has contributed decisively to the making of Romanian modern theatre in the interwar period. This monograph is the chronicle of an outstanding career. The author traces Maican's development as an artist and gives a detailed outline of his work. Influenced by European stage experiments of the time, Maican used new visual techniques and worked intensely with the actors, in order to refine their expressive means and to remove the clichés of the old naturalistic style. Step by step, Maican and a few other stage directors of the new generation succeeded in forging a poetic theatrical language where visual images, gesture, light and music equaled the power of the spoken word. In the course of his activity, Maican has directed a vast array of plays in various Romanian theatres. He gained notoriety in the early thirties with his productions at Jassy National Theatre. They are reviewed in this second chapter of the monograph, which provides relevant historical data, along with a number of documents as yet unpublished.

  14. Gonadotropin Pulsatllity in FemaIe Long Distance Runners

    Science.gov (United States)

    1986-10-24

    findings as well as her current knowledge of this area, she developed her own model of GnRH release. She believe that norepinephrine has a tonic...that . ,·. ~ only long distance runners and cross country skiers had trouble with their menstrual cycles. Similarly, Erdelyi (1976) found a higher

  15. Work-Life Balance: Beyond the Rhetoric. IES Report.

    Science.gov (United States)

    Kodz, J.; Harper, H.; Dench, S.

    The current status of British policy and practice related to work-life balance was examined through case studies of six organizations identified as having well-developed work-life balance and flexible working practices. Interviews were conducted with human resource (HR) managers at all six organizations, and interviews and focus group discussions…

  16. High speed radiometric measurements of IED detonation fireballs

    Science.gov (United States)

    Spidell, Matthew T.; Gordon, J. Motos; Pitz, Jeremey; Gross, Kevin C.; Perram, Glen P.

    2010-04-01

    Continuum emission is predominant in fireball spectral phenomena and in some demonstrated cases, fine detail in the temporal evolution of infrared spectral emissions can be used to estimate size and chemical composition of the device. Recent work indicates that a few narrow radiometric bands may reveal forensic information needed for the explosive discrimination and classification problem, representing an essential step in moving from "laboratory" measurements to a rugged, fieldable system. To explore phenomena not observable in previous experiments, a high speed (10μs resolution) radiometer with four channels spanning the infrared spectrum observed the detonation of nine home made explosive (HME) devices in the 0.98) using blast model functional forms, suggesting that energy release could be estimated from single-pixel radiometric detectors. Comparison of radiometer-derived fireball size with FLIR infrared imagery indicate the Planckian intensity size estimates are about a factor of two smaller than the physical extent of the fireball.

  17. Defeating Improvised Explosive Devices (IED): Asymmetric Threats and Capability Gaps

    Science.gov (United States)

    2011-03-23

    City, Oklahoma bombings in 1995. In order to adapt and avoid detection, terrorists are exploring other options, such as using potassium chlorate ...white, odorless powder) or sodium chlorate (yellow, odorless powder) when making IEDs. High-profile, historic examples include the London attacks...and potassium nitrate. It is the main ingredient found in fireworks. In the past it was used as a propellant powder in ammunition, http

  18. Free, Fair and Efficient? Open Internal Job Advertising. IES Report.

    Science.gov (United States)

    Hirsh, W.; Pollard, E.; Tamkin, P.

    In the 1990s, many major employers in the United Kingdom have moved to more open internal job markets (OIJMs). OIJMs give the job of filling internal vacancies to line managers and employees who see the job advertised and apply for it. The development and operation of OIJMs at the following firms were studied: Rolls-Royce; British Gas Trading;…

  19. Tactical EO/IE System for Ground Forces

    Science.gov (United States)

    1990-09-01

    this thesis is based on these ideas. We will give the guidelines to a project manager or to a beginner in EW research about EO/IR system acquisition...1982 Syria vs Israel Syria: 1 Syria 5+ By Syria: 89 by 96+ Sparrow AIM-9G/L PYTHON Korea: 1 B- Kamchatka 1983 Korea vs USSR 0 0 747(KAL-(07) by AA-3 or

  20. November 1976 Hoarding, ie. the transport and subsequent storing

    African Journals Online (AJOL)

    but for the purpose of this study this term will be extended to cover any form of hoarding ... cycle (16:8) at 30° C. One week's acclimatization to the experimental cage was ... Saccostomus and Desmodillus proved to be true larder-hoarders.

  1. iES - An Intelligent Electronic Sales Platform

    Energy Technology Data Exchange (ETDEWEB)

    Stanton, V L; Korbe III, W; Gao, J G

    2003-10-02

    Current e-commerce systems support online shopping based on electronic product catalogs. The major issues associated with catalog-based commerce systems are: difficulty in distinguishing one retailer from another, complex navigation with confusing links, and a lack of personalized service. This paper reports an intelligent solution to address these issues. Our solution will provide a more personalized sales experience through the use of a transaction-based knowledge model that includes both the rules used for reasoning as well as the corresponding actions. Based on this solution, we have developed an intelligent electronic sales platform that is supported by a framework which provides the desired personalization as well as extensibility and customization capabilities. This paper reports our design and development of this system and application examples.

  2. Un IED sans envergure, une croissance stagnante : le Mercosur ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 déc. 2010 ... [i] Voir CNUCED , 2009, World Investment Report 2009. [ii] Cette note s'inspire des constatations résumées dans 10 Years of Economic Research in the MERCOSUR Network, 2008, ainsi que dans Chudnovsky et Lopez, « FDI and development: the MERCOSUR experience », CEPAL Review, août 2007, p.

  3. CalCOFI Larvae Counts, Scientific Names IE to LA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish larvae counts and standardized counts for larvae captured in CalCOFI icthyoplankton nets (primarily vertical [Calvet or Pairovet], oblique [bongo or ring nets],...

  4. La cartog ra ph ie des inc iden ce s

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    che d'ingénierie des incidences à la recherche pour le développe- ment. .... çoivent des stratégies visant à les doter des outils, techniques et ressources utiles pour contribuer au développement. Axer le ... Comment ? La première phase, la définition des intentions, aide le programme à en arriver à un consensus sur les.

  5. Targeting: Social Network Analysis in Counter IED Operations

    Science.gov (United States)

    2011-06-01

    members caused havoc amongst both French and Algerian citizens by placing bombs in public buildings, police stations, cafes, cinemas , and dance halls in...17 D. FRENCH DISMANTLING OF THE ALN BOMB SECTOR ..................18 IV. INDONESIA’S...effective than fighting a network with a conventional force. This chapter will show how the French were able to combine the two theories of leadership

  6. Muusikamaailm : Suvefestivalid täies hoos / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Suvefestivalidest : Aix-en-Provence'i festivalist, Londoni "Promenaadikontsertidest", Spoleto "Kahe maailma festivalist", Sapporo "Pacific Music Festival'ist", Bregenzi festivalist, New Yorgi Lincoln Center'i festivalist ja Verbieri festivalist

  7. Signature Evaluation for Thermal Infrared Countermine and IED Detection Systems

    National Research Council Canada - National Science Library

    Peters, John F; Howington, Stacy E; Ballard, Jr., Jerry; Lynch, Larry N

    2007-01-01

    .... These simulations provide information ranging from simple temperature contrasts to high-resolution images comparable to actual sensor images that can be used to evaluate or train automatic target recognition (ATR) systems...

  8. Women at a well, Levka [i.e. Lefka

    OpenAIRE

    Thomson, John, 1837-1921, photographer

    2003-01-01

    177 x 115 mm. Woodburytype. A view showing men and women posed in the act of drawing water from a well. The photograph appears in Thomson's 'Through Cyprus with the camera, in the autumn of 1878' (vol.2, London: Sampson Low, Marston, Searle, and Rivington, 1879).

  9. POLITICA DE DISTRIBUŢIE A COMPANIEI MODERNE

    Directory of Open Access Journals (Sweden)

    Grigore Aurica

    2007-05-01

    Full Text Available The economic environmment is in permenent change and the firms try to use more and more thetechnics and instruments of modern marketing. At all points of the modern marketing system people have formedassociations and eliminated various middlemen in order to achieve more efficient marketing. Manufacturersoften maintain their own wholesale departments and deal directly with retailers. Distribution channels can thushave a number of levels. Kotler defined the simplest level, which of direct contact with no intermediariesinvolved, as the 'zero-level' channel. The success condition of firm is represented by her adaptapted capacity,and flexibility to the demand coordinate and to the concurential environment.

  10. The Skills Implications of Electronic Retailing. IES Final Report.

    Science.gov (United States)

    Tackey, Nii Djan; Hillage, Jim; Jagger, Nick; Bates, Peter

    The skills and education/training implications of the development of electronic commerce in the United Kingdom's retail industry and its associated supply chain were examined. The major data collection activities were as follows: a literature review; consultation with leading academics and advisers; an e-mail-based call for information from…

  11. La IED en la industria de tecnologias de la informacion

    Directory of Open Access Journals (Sweden)

    De la Garza, U.

    2005-01-01

    Full Text Available La industria de tecnologías de la información y en especial el sector del software se han constituido en los últimos años como sectores con una gran influencia en todas las ramas de la actividad económica. El conocimiento de sus principales características y de los factores que favorecen las inversiones en los sectores mencionados pueden ayudar a generar acciones que favorezcan su crecimiento y desarrollo, a fin de que los efectos transversales que se tienen impacten favorablemente en el crecimiento económico del país.

  12. Kümme aastat taasiseseisvunud Eestis / Õie Tammissaar

    Index Scriptorium Estoniae

    Tammissaar, Õie, 1949-

    2003-01-01

    Rets. rmt.: Raamatukogud ja raamatukogundus taasiseseisvunud Eestis 1991-2001 : artiklite kogumik = Libraries and librarianship in newly independent Estonia 1991-2001 : collection of articles / RR ; koost. Anu Nuut. Tallinn, 2002. 238 lk. : ill

  13. ) E STRYI) TEE~ I)IE VOOR()OST

    African Journals Online (AJOL)

    vyandelike voetsoldate op te tree. Volgens 5. SA Infanteriebrigadegroephoofkwartier se een ..... van hulle is kpl R. R. G. White, wat sy een oog verloor het. Sktr A. B. Cunningham van. 3 Transvaal Scottish se C ... toe hulle dit nader as 2000 tree van die sen- trale fortifikasies waag en slaag oak daarin am die pantserkarre aan ...

  14. d ie penne st rydtu sse nd ie chr ist ene en he id eneg ed ur en ded ...

    African Journals Online (AJOL)

    Test

    is so oud as die Christendom self. Die doel van hierdie artikel is om kortliks na te gaan waiter aanvalle die Christene gedurende die eerste drie eeue van die kant van die heidene geleerdes ondervind, en hoe hulle daarop reageer het. Die heidense letterkunde tot ongeveer die middel van die tweede eeu bevat besonder ...

  15. Hoe kbesp re kill J,tsl Boo kR e~~ie"~s

    African Journals Online (AJOL)

    en verbly- dend - dat daar nog uitgewers is wat bereid is om goeie boeke te bemark, ongeag die geringe aantallesers van histories-wetenskaplike werke. Kapt A. E. van daarsveldt. MEREDITH, Martin: The past is another country, Rhodesia. 1890-1979 London, Deutsch, 1979. Hierdie boek voorsien in 'n leemte betreffende.

  16. Relación entre la Inteligencia Emocional y la Capacidad de Atención - Concentración en estudiantes de 2º grado de educación secundaria de la I.E. “Gran Amauta” N° 3037, del Distrito de San Martín de Porres, 2014.

    OpenAIRE

    Taira Oshiro, Stephanie Chiemy

    2015-01-01

    Lo que se realizó en esta investigación fue determinar la relación que existe entre la Inteligencia Emocional y la capacidad de Atención - Concentración en los estudiantes de segundo grado de secundaria de la I.E “Gran Amauta” distrito de San Martin de Porres, 2014. Esta investigación corresponde al enfoque cuantitativo. Es una investigación básica sustantiva que se ubica en el nivel descriptivo. El diseño de la investigación ha sido correlacional de corte transversal, que e...

  17. Modelo Pedagógico Crítico para el Desarrollo de Capacidades del Pensamiento Científico de los Estudiantes del Area de Ciencia -Tecnología y Ambiente de la I.E. Mayta Capac de Educación Secundaria.

    OpenAIRE

    Mendoza Urquizo, Consuelo Lourdes

    2017-01-01

    l presente trabajo de tesis Modelo Pedagógico Crítico para el Desarrollo de Capacidades del Pensamiento Científico de los Estudiantes del Área de Ciencia, Tecnología y Ambiente de la I.E. Mayta Capac de Educación Secundaria, surge como respuesta de la problemática de bajo nivel de desarrollo de capacidades del pensamiento científico en los estudiantes, condicionado por diversos factores, de los cuales la enseñanza inapropiada constituye el factor de mayor relevancia. El objetivo que se persi...

  18. Relación entre el clima social familiar y la autoestima de los estudiantes del cuarto grado de educación secundaria de la I.E. Isabel Chimpu Ocllo del distrito de San Martín de Porres - Lima

    OpenAIRE

    Pejerrey Campodónico, Rubeni

    2015-01-01

    El presente trabajo se originó gracias a la convivencia diaria con los estudiantes de la IE Isabel Chimpu Ocllo en la que surge la necesidad por determinar la relación entre el clima social familiar y la autoestima de los estudiantes, toda vez que merecen ser comprendidos y orientados adecuadamente ante cuestiones evidentes donde los adolescentes en su mayoría manifiestan actitudes impacientes, violentas e irrespetan las normas de convivencia. El trinomio de la educación: estudiantes, padres ...

  19. Aplicación del Software MAT6 y su influencia en el rendimiento académico en el área de matemática del sexto grado de la I.E. 6020 Villa María del Triunfo, 2012

    OpenAIRE

    Rojas Vargas, Jesús Luis Alberto; Chuquihuamaní Aguilar, Wilder José

    2015-01-01

    El bajo rendimiento académico en matemática de los escolares es un problema que muchos docentes tratan de superar aplicando variadas estrategias en la enseñanza de matemática. En ese sentido, esta investigación busca responder el problema general: ¿Cómo influye la aplicación del software Mat6 en el rendimiento académico en el área de matemática de los estudiantes de sexto grado de primaria de la I.E. 6020. Villa maría del Triunfo, 2012? y como objetivo general: Explicar la i...

  20. 15.SFPS "Ieņēmumi no līgumiem ar klientiem"un 16.SFPS "Noma" prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu

    OpenAIRE

    Dābola, Iveta

    2016-01-01

    Maģistra darba temats 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu. Maģistra darba mērķis - balstoties uz 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” standartu prasību izpēti un analīzi, novērtēt Latvijas likumdošanas atbilstību minēto standartu prasībām un sniegt priekšlikumus konkrētu jautājumu risināšanai Latvijas kontekstā. Maģistra darbā izpētīti LR normatīvie regulējumi un sta...

  1. Conocimiento de los padres sobre hábitos bucales deformantes y traumas dentales asociados a las alteraciones bucales en niños de 4 a 10 años de edad de la I.E. Nuestros Héroes de la Guerra del Pacífico del distrito de Tacna, 2012

    OpenAIRE

    Aparcana Díaz, José Alfredo

    2013-01-01

    El objetivo se centró en determinar si se asocia el conocimiento que poseen los padres sobre hábitos bucales deformantes y traumas dentales con las alteraciones bucales en niños de 4 a 10 años de edad de la I.E. Nuestros Héroes de la Guerra del Pacífico del distrito de Tacna en el periodo 2012. El diseño fue no experimental, descriptivo transversal y de asociación. La población de estudio, fueron 248 padres y 248 hijos/as escolares de 4 a 10 años. Se utilizó un test de conocimientos de ...

  2. AMENINȚAREA SAU VIOLENȚA SĂVÂRȘITĂ ASUPRA UNEI PERSOANE CU FUNCȚIE DE RĂSPUNDERE SAU A UNEI PERSOANE CARE ÎȘI ÎNDEPLINEȘTE DATORIA OBȘTEASCĂ (art.349 DIN CODUL PENAL: ANALIZĂ DE DREPT PENAL

    Directory of Open Access Journals (Sweden)

    Vitalie STATI

    2017-07-01

    Full Text Available Obiectul studiului de față îl formează elementele constitutive și circumstanțele agravante ale infracțiunilor specificate la art.349 CP RM. În rezultatul analizei efectuate, se stabilește că obiectul juridic special al acestor infracţiuni are un caracter multiplu. Se relevă că victimă a infracţiunilor prevăzute la art.349 CP RM este, după caz: a persoana cu funcţie de răs­pundere; b persoana care îşi îndeplineşte datoria obştească; c ruda apropiată a persoanei cu funcţie de răspundere sau a persoanei care îşi îndeplineşte datoria obştească. Se arată că, în cazul infracţiunilor specificate la art.349 CP RM, legătura dintre comiterea infrac­ţiunii şi activitatea de serviciu sau obştească a victimei are un caracter obligatoriu. De fiecare dată, la calificare, urmează să se verifice dacă au fost încălcate sau nu regle­mentările care stabilesc condiţiile şi limitele îndeplinirii de către victimă a obligaţiilor de serviciu sau obşteşti. Doar în lipsa unor asemenea încălcări poate fi aplicat art.349 CP RM. Se ajunge la concluzia că art.349 CP RM nu poate fi aplicat în cazul în care, la momentul comiterii infrac­ţiu­nii, făptuitorul nu-şi dădea seama că: a săvârşeşte infracţiunea asupra unei persoane cu funcţie de răspundere care îşi desfăşoară activitatea în cadrul unei autorităţi publice, a unei persoane care îşi îndeplineşte datoria obştească sau a unei rude apropiate a acestora; b infracţiunea pe care o săvârşeşte are legătură cu i activitatea de serviciu a persoanei cu funcţie de răspundere care îşi desfăşoară activitatea în cadrul unei autorităţi publice sau cu ii activitatea obştească a persoanei care îşi îndeplineşte datoria obştească. Se argumentează că răzbunarea în legătură cu îndeplinirea de către victimă a datoriei obşteşti poate deter­mina comiterea infracţiunilor prevăzute la art.349 CP RM. Totodată, r

  3. A autoavaliação institucional no processo de tomada de decisão em IES: estudo de caso das Faculdades SENAC/SC Institutional self-evaluation in the decision-making process at HEIs: a case study of SENAC/SC higher education school

    Directory of Open Access Journals (Sweden)

    Elita Grosch Maba

    2012-07-01

    Full Text Available O presente artigo pretende demonstrar em seu contexto a relação existente entre o sistema de autoavaliação institucional e o processo de tomada de decisão, especificamente nas Faculdades de Tecnologia pertencentes à Administração Regional do SENAC-SC. Utilizando uma amostra intencional deste universo, o estudo, realizado em 2010, é caracterizado como descritivo-exploratório, do tipo quali-quantitativo, mediante a aplicação de uma pesquisa bibliográfico-documental, configurada como um estudo multicaso. Nas seis unidades investigadas, foram entrevistados: o diretor da unidade e os coordenadores de áreas (Núcleo Relações com o Mercado, Núcleo Administrativo Financeiro e Núcleos Educacional Básico e do Ensino Superior, aplicando-se um questionário estruturado com questões abertas e fechadas, permitindo a avaliação de aspectos objetivos e quantificáveis e subjetivo-discursivos. Os resultados apontam para a autoavaliação institucional como facilitadora do processo decisório, provendo informações que permitem avaliar determinada situação. Adicionalmente, identificam os pontos fortes e fracos da IES e que melhoram a qualidade das decisões estratégicas, o que confirma a existência da relação pressuposta acima, bem como a importância do processo de autoavaliação institucional. Mostram, ainda, a necessidade de revisão da estrutura, visando aprimorar a apropriação dos dados levantados pela autoavaliação e aplicados como suporte no processo de tomada de decisão das instituições do universo analisado. Por fim, a hipótese de pesquisa, em base a esses resultados, acabou sendo validada, ratificando tal relação.This article presents, briefly, the master thesis that gave rise and that analyzes the institutional self-evaluation and the decision-making process at SENAC-SC and the relationship between them. By using an intentional sample of six technology universities belonging to the regional administration of SENAC

  4. D IE M IST IEK — 'N B E SK O U IN G V O L G E N S D IE ST A N D ...

    African Journals Online (AJOL)

    Test

    tariaat ge!d, die absolute waarheid moet wees. ,Dié waarheid is vir. Berdjajew onafhank!ik, dit word gedien, is abso!uut en dien nie. Hy het 'n vaste ge!oof in die persona!istiese aristokrasie van die gees. Vanuit Rus!and is hy na Duitsland. Met die fascisme en Nazi- isme kon Berdjajew egter ook nie volkome tereg kom nie.

  5. Eff1, IE3. And what then? Pt. 3. Types of motors. Idle power; Eff1, IE3. Und was dann? T. 3. Motorarten. Blindleistung

    Energy Technology Data Exchange (ETDEWEB)

    Fassbinder, Stefan [Deutsches Kupferinstitut, Duesseldorf (Germany); Steins, Dieter

    2012-07-01

    The authors of the contribution under consideration report on motors using permanent magnets for electric driven automobiles. Especially, the authors try to give an answer to the question on how to enhance the efficiency of engines. A possibility is the switch to rotors consisting of copper.

  6. Identification and HLA-Tetramer-Validation of Human CD4(+) and CD8(+) T Cell Responses against HCMV Proteins IE1 and IE2

    DEFF Research Database (Denmark)

    Braendstrup, Peter; Mortensen, Bo Kok; Justesen, Sune Frederik Lamdahl

    2014-01-01

    tumor development. Both CD4(+) and CD8(+) T cell responses are important for long-term control of the virus, and adoptive transfer of HCMV-specific T cells has led to protection from reactivation and HCMV disease. Identification of HCMV-specific T cell epitopes has primarily focused on CD8(+) T cell...

  7. Development of physical culture among the school youth of Donbass (20-ies of XX century

    Directory of Open Access Journals (Sweden)

    Galchenko A.N.

    2010-10-01

    Full Text Available The politics of the Soviet authority in business of introduction physical training in an education system is shined. The condition of process of physical development is considered within the limits of school educational institutions. The place of physical training in structure of the general education of youth is found out. Diffculties of an initial stage are analyzed. Shift and dynamics of process are traced. It is marked, that already at the end of frst half of 1920 to process of physical development the most part of schools of Donbass has joined.

  8. IE Information No. 86-104: Unqualified butt splice connectors identified in qualified penetrations

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    During an NRC equipment qualification (EQ) inspection at Dresden Nuclear Power Station, May 19--23, 1986, a deficiency was discovered concerning a lack of similarity between tested and installed nylon insulated butt splices in EQ qualified GE electrical penetrations. commonwealth Edison sent four sample splices removed from Quad Cities Nuclear Power Station to Wyle Laboratory to further substantiate their qualification for use in a harsh environment. These splices were identical to those installed at Dresden. During the testing performed at Wyle Laboratory December 4--5, 1986, all four samples exhibited excessive leakage currents to ground when exposed to a steam environment. Commonwealth Edison consequently declared the splices unqualified and shut down its Quad Cities Unit 1 to rework the splices by wrapping them with previously qualified tape. Dresden Unit 2 has similarly reworked the splices by wrapping them with tape. Duane Arnold Energy Center also has commenced a shutdown in order to make repairs. The short circuits that occurred appeared to start by condensation entering the splice between the wire insulation and the nylon tubing. The arcing caused insulation degradation that then allowed arcs to pass through the insulation to the enclosure

  9. Jihadist Cells and IED Capabilities in Europe: Assessing the Present and Future Threat to the West

    Science.gov (United States)

    2012-11-01

    Miller, “A Prelimi- nary Typology of Organizational Learning: Synthesizing the Lit- erature,” Journal of Management, Vol. 22, No. 3, 1996, pp. 485- 505 ...Alison Pargeter, The New Frontiers of Jihad: Radical Islam in Europe, Philadelphia, PA: University of Pennsylva- nia Press, 2008, chap. 10. 50. It

  10. Synthesis of IES Research on Early Intervention and Early Childhood Education. NCSER 2013-3001

    Science.gov (United States)

    Diamond, Karen E.; Justice, Laura M.; Siegler, Robert S.; Snyder, Patricia A.

    2013-01-01

    A primary purpose of early childhood education and interventions is to promote children's acquisition of knowledge and skills linked to later social competence and academic success. In this report, special attention is given to summarizing what has been learned about early childhood classrooms as contexts for development and learning, the kinds of…

  11. From Admin to Strategy: The Changing Face of the HR Function. IES Report 332.

    Science.gov (United States)

    Tamkin, Penny; And Others

    Evidence from academic research and management experts in the United Kingdom and elsewhere confirms that the recent focus in work organizations on cost reductions through downsizing has changed the roles and structures of many human resources (HR) units. HR units have had to prove their contribution to the organization's bottom line, raise their…

  12. Intellectuele-eigendomsrechten als verhaalsobject : verhaal van vorderingen door uitwinning van ie-rechten in Nederland

    NARCIS (Netherlands)

    Keur, A.I.

    2016-01-01

    Purpose of this research is to explore to what extent it is possible and useful to collect debts by sale of intellectual property rights (ip-rights) under execution in the Netherlands governed by the laws of the Netherlands. Due to their specific characteristics ip-rights “behave” differently than

  13. IE Information No. 87-08: Degraded motor leads in Limitorque dc motor operators

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    On May 6, 1986 the NRC received from Portland General Electric Company a 10 CFR 21 report concerning a motor failure which occurred at its Trojan Nuclear Power Plant. The failure involved shorting of the motor leads inside a Limitorque motor operator connected to an auxiliary feedwater flow control valve. Upon inspection it was determined that the failure was the result of insulation degradation of the motor leads that had allowed two leads to short together. Recently, the NRC has also learned of a failure at the Turkey Point Nuclear Power Plant in which the steam supply valve for the auxiliary feedwater turbine failed to operate after a Limitorque motor operator experienced a similar motor lead short circuit. The Trojan and the Turkey Point Limitorque operators were found to contain motors manufactured with Nomex-Kapton insulated leads. On January 12--14, 1987, the NRC conducted an inspection at Peerless-Winsmith, Inc., manufacturer of dc motors for Limitorque Co. During this inspection it was determined that the failed Nomex-Kapton leads were different than the leads which were fitted to the motors, tested, and documented in Limitorque Qualification Report B-0009 for dc motor operators. The leads attached to the tested motors were insulated with Nomex plus an epoxy impregnated braided fiberglass sleeve. The NRC knows of no analysis or testing that has been performed to show the Nomex-Kapton leads are acceptable for use in an application requiring environmental qualification. Further, it should be noted that the failures cited above occurred under normal operating conditions, not under the harsh conditions which could occur in areas where environmental qualification is required

  14. IE Information Notice No. 85-17, Supplement 1: Possible sticking of ASCO solenoid valves

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    This notice is to inform recipients of the results of follow up investigations regarding the reasons for sticking of Automatic Switch Company (ASCO) solenoid valves used to shut main steam isolation valves (MSIVs) under accident conditions. GE has recommend that the licensee replace the potentially contaminated MSIV solenoid valves and institute a periodic examination and cleaning of the MSIV solenoid valves. Grand Gulf has replaced the eight MSIV HTX832320V dual solenoid valves with fully environmentally qualified ASCO Model NP 8323A20E dual solenoid valves. The environmentally qualified valve Model NP 8323A20E was included in a control sample placed in the test ovens with the solenoid valves that stuck at Grand Gulf. The environmentally qualified model did not stick under the test conditions that cause sticking in the other solenoid valves

  15. L'investissement étranger direct (IED) dans les pays à faible revenu ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... investment (FDI) behaviour in low and middle-income countries; final technical report covering the period from 10 March 2006 to 9 January 2009. Download PDF. Reports. Does foreign direct investment lead or follow development? : differences in FDI behavior in low- and middle-income countries; final technical report.

  16. West Valley Reprocessing Plant. IE inspection report No. 75-8

    International Nuclear Information System (INIS)

    1975-01-01

    Results of an inspection of the West Valley Processing Plant on October 20-23, 1975 are reported. The inspection consisted of selective examinations of procedures and representative records, interviews with personnel, and observations by the inspector. No items of noncompliance were observed

  17. Schengen Facility hankeprojektid on täies hoos / Helena Loorents

    Index Scriptorium Estoniae

    Loorents, Helena

    2005-01-01

    Schengen Facility toetusest uutele EL-i liikmesriikidele. Schengen Facility programmi vahenditest toetatakse Eesti piirivalvele RIB C-1100 tüüpi paatide ning piirivalvekopter hankimist, valminud on uus merevalvekeskus

  18. kant geveg het) aan sv lesers vaor Ie. Die deel sol" aFgesluit word ...

    African Journals Online (AJOL)

    Uggla se verslag oor die herdenkingsbveenkomste von die slog von. MogersFontein (Stockholm, 1926). Op p. ix von die publikasie verskvn 'n bibliograFie von bestaande werke in AFrikoons, Engels en. Nederlands wat oandog oan die lotgevalle ...

  19. Vabaõhulavastuse "Jõujaam" proovid käivad täie hooga / Jan Rahman

    Index Scriptorium Estoniae

    Rahman, Jan, 1975-

    2007-01-01

    Leevaku hüdroelektrijaama juures etendub jaanipäeva paiku Jan Rahmani kirjutatud näitemäng "Jõujaam", lavastaja Raivo Adlas. Mängib Räpina näitemänguseltskond. Näitekirjanik tutvustab lavastust

  20. BDTPS The BNCT Treatment Planning System jointly developed at DIMNP and JRC/IE

    CERN Document Server

    Daquino, G G; Mazzini, M; Moss, R; Muzi, L; International Workshop on "Neutron Capture Therapy: State of the art"

    2003-01-01

    The idea to couple the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the new methodology set-up at DIMNP of University of Pisa, in collaboration with the JRC of Petten (NL). The methodology has been implemented in the new TPS, called BDTPS (Boron Distribution Treatment Planning System), which takes into account the actual boron distribution in the patient brain, while the standard TPS assumes a uniform boron distribution, absolutely far from the reality. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The new TPS, based on the Monte Carlo technique, has been validated comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designed, as calculated by the BDTPS and by the standard TPS SERA. An evident SERA overestimation of the thermal neutron flux, as well as the boron dose, has been detect...

  1. "Uinuv kaunitar" tuleb Jõhvi täies hiilguses / Irina Kiviselg

    Index Scriptorium Estoniae

    Kiviselg, Irina, 1961-

    2009-01-01

    Jõhvis balletifestivalil saab näha 6.-7. veebr. 2009 vene klassikalist balletti "Uinuv kaunitar". Peaosades Jevgeni Ivantšenko ja Irina Golub Peterburi Maria teatrist ning Londoni teatri solistid Age Oks ja Toomas Edur

  2. Hiiglasliku uinunud Buddha kuju otsing jätkub täie hooga / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Afganistani arheoloog Zemarzyali Tarzi leidis 19-meetrise lamava Buddha kuju. Arheoloog tahab taastada Talibani poolt hävitatud 38 ja 55 meetrit kõrged Buddha kujud, mis olid püstitatud 6. sajandil

  3. IE Information No. 86-71: Recent identified problems with Limitorque motor operators

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    This notice is provided to alert recipients of two potential problems discovered with Limitorque motor operators. On November 8, 1985 Georgia Power Company submitted a preliminary report to the NRC indicating that it had discovered burn damage to internal wiring in several Limitorque motor operators installed in their Vogtle Unit 1 Power Plant. On March 20, 1986 Georgia Power Company submitted a final report to the NRC which suggested that the burn damage was a generic problem applicable to all Limitorque motor operators. This assumption was based on a sampling inspection of 104 Limitorque motor operators installed in Vogtle Unit 1. Forty-six of the motor operators examined were Limitorque type SMB-000, and six of these were found to have burnt internal wiring. Out of the 58 operators other than type SMB-000 which were inspected, 5 were found to contain wires deemed susceptible to damage because of their close proximity to the heater elements (less than 1/2 inch). Several licensees have submitted reports to the NRC concerning a problem with cracked limit switch rotors on Limitorque motor operators installed inside and outside of containment. The limit switches are used for control of the motor operator and also provide indication of valve position in the control room. The cracks have been found on white melamine limit switch rotors. Most of these cracks were found in the area where the limit switch rotors are pinned to the pinion shafts. Some cracks have been found to extend halfway through the melamine rotors, weakening them to the extent that they are easily broken

  4. EDUCAŢIE FORMALĂ, NONFORMALĂ ŞI INFORMALĂ: PERSPECTIVELE NOILOR EDUCAŢII

    Directory of Open Access Journals (Sweden)

    Carolina ŢURCANU

    2017-07-01

    Full Text Available În articol este abordată problema ce vizează noile educaţii în contextul educaţiei formale, nonformale şi informale. Accentul se pune pe analiza tendinţelor pe plan internaţional şi naţional în vederea valorificării mai eficiente a noilor educaţii în condiţiile schimbării potenţialului formativ al educaţiei formale spre educaţia nonformală şi informală.FORMAL, NON-FORMAL AND INFORMAL EDUCATION: NEW PERSPECTIVES OF EDUCATIONThe approach of the article is the problem of new educations in context of formal, non-formal and informal educations. The focus is on the analysis of trends on national and international level, in order to exploit more effectively the new educations in changing conditions of the formative potential of the formal to non-formal and informal educations.

  5. geestd er eeuw ", 'nnederland se kontro vers in d ie eer st ...

    African Journals Online (AJOL)

    Test

    den arbeid en zijn loon. De Maatschappij gevoelt haar evenwicht verstoord. Haar lichaam kwijnt en woelt bij beurten: 't is de plaag van kankrend pauperisme . .. . En reeds voorspel hy „d'onoverzienbre krijg der Armen en der. Rijken". Die belangrikste gebeurtenis in hierdie stryd tussen verlig- ting en reaksie in Nederland is ...

  6. Insecticidal and Repellent Activit ies of Laurinterol from the Okinawan Red Alga Laurencia nidifica

    Directory of Open Access Journals (Sweden)

    Takahiro Ishii

    2017-01-01

    Full Text Available An ethyl acetate (EtOAc extract of Laurencia nidifica was found to have toxic effect against brine shrimp larvae (Artemia salina. Bioassay-guided fractionation of the EtOAc extract resulted in the isolation of four known halogenated sesquiterpenes, laurinterol (1, isolaurinterol (2, aplysin (3, and a -bromocuparene (4. Their structures were established on the basis of spectral analysis and comparison with literature data. Among isolated compounds, only laurinterol showed strong toxicity against A. salina. Further experiments revealed that laurinterol also exhibited repellent activity against the maize weevil Sitophilus zeamais , insecticidal activity against the termite Reticulitermes speratus, and acetylcholinesterase (AChE inhibitory effect . This is the first report of insecticidal and repellent activities of laurinterol.

  7. The IE Middle Voice: A Study in Syntactic Strategy and Syntactic Change.

    Science.gov (United States)

    Barber, Elizabeth

    The active/passive system of English grew out of a Proto-Indo-European (PIE) system where the fundamental distinction was between active and middle voices. The middle voice included within its functions the relationship that now would be known as passive. The PIE voice system is preserved in ancient Greek and Sanskrit, and in the former, the…

  8. Išvestinio ieškinio samprata, paskirtis ir tikslai

    OpenAIRE

    Mikalonienė, Lina

    2014-01-01

    The shareholder’s derivative action has been transplanted into the Lithuanian Corporate Law (e.g. the Law on Stock Companies, Art. 16 str. part 1 par. 5), but has not received great interest from the national scholars. Analyzes of the shareholder’s derivative action starts with the key general aspects of the action, e.g. its concept, rationale and goals. It is concluded in the article that shareholder’s derivative action is used to protect different private interests. First, since the company...

  9. Physics of IED blast shock tube simulations for mTBI research

    NARCIS (Netherlands)

    Mediavilla Varas, J.; Philippens, M.M.G.M.; Meijer, S.R.; Berg, A.C. van den; Sibma, P.C.; Bree, J.L.M.J. van; Vries, D.V.W.M. de

    2011-01-01

    Shock tube experiments and simulations are conducted with a spherical gelatin filled skull- brain surrogate, in order to study the mechanisms leading to blast induced mild traumatic brain injury. A shock tube including sensor system is optimized to simulate realistic impro-vised explosive device

  10. Effect of number of piles [i.e. plies] on the tear resistance of paper

    Science.gov (United States)

    James T. Swartout; Vance C. Setterholm

    1963-01-01

    Tear tests made on low-finish bond paper and a 42-pound linerboard showed that the tear resistance, the degree of spreading of the plies, and the deviation from a straight line of failure increased with the increase in the number of plies tested. Tests on plies of aluminum foil indicated this degree of variation due to multiplicity of plies lay not in the tester but in...

  11. On the Agenda: Changing Nurses' Careers in 1999. IES Report 360.

    Science.gov (United States)

    Robinson, Dilys; Buchan, James; Hayday, Sue

    A survey of a random sample of 6,000 registered nurses who were members of the Royal College of Nursing explored views on issues related to working as a nurse and having a career in nursing. Recent policy documents highlighted the high value the government placed on the role of nurses. Results indicated there were clear gender differences with…

  12. Greenlandic Peregrines will have normal eggshell thickness by mid 2030’ies

    DEFF Research Database (Denmark)

    Falk, Knud; Møller, Søren; Riget, Frank Farsø

    haliaetus) in Europe have documented that it took 30 years from DDT was phased out until eggshell thickness was back to normal pre-DDT levels. In Greenland, the peregrine population has been the subject of long-term studies, and a previous study of eggshell thinning found a significant increase over time...... and reinterpreted data for a 43 year time span. Mean shell thickness was estimated for 184 clutches based on fragments from hatched eggs, and for 56 whole addled eggs from 44 clutches. During the period 1972-2014 there was a highly significant increasing trend in the average eggshell thickness of 0.25% per year...... recovery of the shell thickness in the Greenland population as compared to other studies is likely indicative of the slower phasing out of DDT in the Greenlandic peregrine’s wintering grounds in Latin America. The shell thinning in the Greenlandic population crossed the 17% “danger limit” associated...

  13. Posibile sisteme de justiție administrativă - Examen de drept comparat

    Directory of Open Access Journals (Sweden)

    Dacian C. DRAGOŞ

    2002-06-01

    Full Text Available The article presents the main models of administrative justice, the differences between them and the importance of chosing one or another. Romania, being engaged in a proces of modernisation of the national administration, has to take care also of the means to control the administration, the most important of which is the judicial control of administrative decisions. Over the years, two systems have struggled for supremacy in administrative justice: the French system, characterized by the existence of the administrative courts, separate from the judicial courts, and the British system, where all law suits, including the administrative ones, are judged by judicial courts.

  14. Pro Internet Explorer 8 & 9 Development Developing Powerful Applications for the Next Generation of IE

    CERN Document Server

    Crowley, Matthew

    2010-01-01

    This book is an in-depth guide to writing applications that embrace and extend the new features and capabilities of Windows Internet Explorer 8 and 9. With solid instruction, hands-on examples, and expert insight direct from the source into extending the browser, you'll learn how to create and maintain powerful applications for Microsoft's next-generation Internet platform. Join author Matthew Crowley as you discover how to take advantage of new features like accelerators, WebSlices, and search providers, and create intense web experiences for the browser that ships by default with the popular

  15. [Soft tissue-cutting law, i.e. the career concept of an autopsy assistant].

    Science.gov (United States)

    Kormos, Timea; Csatai, Tamás; Jäckel, Márta

    2015-03-08

    Practical experience shows that the autopsy assistant society is fairly divided. There are some people who would have needed a thorough basic training, and there are those who - due to their diligence and the close cooperation with physician colleagues - would deserve an opportunity for further progress due to their extensive knowlegde. As regards the autopsy assistant profession the training, and the training system as well has changed significantly, and it requires further changes. Examining the issue in a wide spectrum, the aim of the authors is, as much as possible, to promote the formation of an "Autopsy assistant career," in which they want to create a predictable way for the members of the profession from the phase of becoming a student (competency, training, exams, vocational training, single note) to obtaining the master's degree. The authors would like to provide a summary about their experience and plans regarding this issue.

  16. Euroveokid soosivad Venemaal käies üha enam Via Hanseaticat / Madis Aesma

    Index Scriptorium Estoniae

    Aesma, Madis

    2005-01-01

    Ajal. Postimees lüh. Pärast Balti riikide ühinemist Euroopa Liiduga kasutavad välismaa veoautojuhid üha enam Euroopast Venemaale sõitmiseks Valga-Tartu-Jõhvi-Narva maanteed, mis moodustab Via Hanseatica ehk Hansatee Eesti osa. Lisa: Via Hanseatica. Kaart: Visa Hanseatica

  17. ŢARA ZĂRANDULUI CA PROIECŢIE SPAŢIALĂ MENTALĂ

    Directory of Open Access Journals (Sweden)

    Nicoleta DAVID

    2009-07-01

    Full Text Available The Land of Zărand as Metal Spatial Projection.The physical support of the Zărand mental space is represented by the morphology of the region, by the forestry domain (generator of a special type of behaviour and of peculiar occupations, by the mining activity (especially the one related to the gold-bearing veins and by the historical events that led to the heroic mythology. The stages in the development of the Land of Zărand into an open mental space took place gradually based on the transfer of influence from the Zărand Fortress towards the interior of the mountains, towards the future settlements with role of central place, namely Baia de Criş and Brad.

  18. ŢARA ZĂRANDULUI CA PROIECŢIE SPAŢIALĂ MENTALĂ

    OpenAIRE

    Nicoleta DAVID

    2009-01-01

    The Land of Zărand as Metal Spatial Projection.The physical support of the Zărand mental space is represented by the morphology of the region, by the forestry domain (generator of a special type of behaviour and of peculiar occupations), by the mining activity (especially the one related to the gold-bearing veins) and by the historical events that led to the heroic mythology. The stages in the development of the Land of Zărand into an open mental space took place gradually based on the transf...

  19. Barnwell Nuclear Fuel Plant. IE inspection report No. 75-13

    International Nuclear Information System (INIS)

    1975-01-01

    Copies of the following documents are presented: letter to N. C. Moseley from Allied-General Nuclear Services dated October 16, 1975; letter to Allied-General Nuclear Services from N. C.Moseley dated October 7, 1975; and Region II Inspection Report No. 50-332/75-13

  20. Improving Situational Awareness in the Counter-IED Fight with the Utilization of Unmanned Sensor Systems

    Science.gov (United States)

    2009-06-01

    Resistant Ambush Protected (MRAP) vehicles, which were designed to withstand an antitank mine (Eisler, 2007). An EFP can penetrate a thickness of armored...These robots weigh less than 100 pounds, are man-portable, and move on small treads with seven speed settings. The TALON is controlled with a...is powered by a two-stroke piston engine and has a steerable nose and main gear, with tires suitable for rough terrain. The Tern utilizes a GPS

  1. Distribution and mechanism of Type I-E CRISPR-Cas systems

    NARCIS (Netherlands)

    Staals, R.H.J.; Brouns, S.J.J.

    2013-01-01

    Although the CRISPR type I system encompasses six different subtypes (I-A to I-F), only three subtypes have been studied in detail to date. This review includes an analysis of the distribution of CRISPR-Cas systems among the different bacterial and archaeal lineages, and will focus on our

  2. ISEll'$?,l'iifilfi WAtJiE~G®NTR*OiLit.,IED

    African Journals Online (AJOL)

    transistor TRI (2N3773), which controls the electronic switch unit. The capacitor C3. (470pF) is placed at the output of the rectifier to smoothen the rectified signal and maintain an effective trigger voltage for the transistor. TR1. Electronic Switch. The electronic switch is basically controlled by the transistor TR1 and the electro-.

  3. Incidences de l'investissement étranger direct (IED) sur la pauvreté ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un numéro spécial de la revue met en lumière les conclusions d'une étude financée par le CRDI sur le travail rémunéré des femmes. Policy in Focus publie un ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne remporte le prix de la diplomatie scientifique. L'Initiative des ...

  4. 4R 31TR4SIE TY[)E~S [)IE EOEREOORLOG

    African Journals Online (AJOL)

    Adolf Hitler aangehaal deur F. L. Schuman,. International Politics, p. 174. Die belangrikste uitvloeisel van die Den Haag byeenkoms was sekerlik die feit dat daar vir die eerste keer in die geskiedenis 'n poging aangewend is om 'n internasionale organisa- sie in die Iewe te roep met regeringsteun, om oorlog te bekamp.

  5. NDOGM EN H IST OR IES OOG PU NT BESIEN . Die Apostoliese

    African Journals Online (AJOL)

    Test

    ou kerkleraars oer die hiernamaals heidense bestanddele bevat het, waardeur die beskouing van die Roomse Kerk oor die nederdaiing be- invloed is. Rome leer dat die hiernamaals vyf verskillende plekke bevat. Christus het na een van daardie vyf plekke afgedaal. en wel na die verblyfplek van die gelowiges wat voor sy ...

  6. Aging studies of batteries and transformers in class IE power systems

    International Nuclear Information System (INIS)

    Edson, J.L.; Roberts, E.W.

    1992-01-01

    A Phase I aging study of batteries used in 1E Power Systems of nuclear power plants concluded that significant aging effects for aged batteries are growth of positive plants, loosening of active material in plates that have grown, loss of active material caused by gassing and corrosion, and embrittlement of the lead grids and straps. These effects contribute to decreased electrical capacity and decreased seismic ruggedness which, during a seismic event, can lead to decreased electrical performance or complete failure. Subsequently a Phase II test program was conducted to determine if seismic ruggedness of aged batteries can be inadequate even if the electrical capacity is satisfactory, as determined by tests recommended by IEEE Std 450-1987, open-quote IEEE Recommended Practice for Maintenance, Testing, and Replacement of Large Storage Batteries for Generating Stations and Substations.close quotes In addition, a Phase I aging study of transformers in 1E Power Systems was performed to identify stressors and failure mechanisms, investigate whether transformers are showing the effects of aging as they grow older, and to determine if current surveillance methods are effective in mitigating aging effects. This paper presents the results of these studies

  7. Vers une meilleure comprehension des savoirs disciplinaires et curriculaires des enseignants ou Ie paradigme retrouve

    Directory of Open Access Journals (Sweden)

    Stephane Martineau

    1999-01-01

    Full Text Available eet article se veut essentieUement un travail de synthese sous la forme d 'une breve revue de litterature au sujet des savoirs disciplinaires et curriculaires en enseignement. Plus specifiquement, il vise a determiner queUes sont les principales conclusions qui se degagent de la lecture des recherches empiriques sur les savoirs disciplinaires et curriculaires des enseignants des ordres d'enseignement primaire et secondaire. Il propose donc une classification des differentes dimensions constitutives du rapport entre les savoirs disciplinaires et curriculaires et la pratique enseignante. Les resultats mis au jour permettent d 'une part, d'identifier les facteurs qui entrainent des differences dans les connaissances disciplinaires et curriculaires des enseignants et d'autre part, de mieux saisir comment ces connaissances de l'enseignant peuvent influencer en retour sa pratique.

  8. TU-H-CAMPUS-IeP1-02: Validation of a CT Monte Carlo Software

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, R; Wulff, J; Penchev, P [Technische Hochschule Mittelhessen - University of Applied Sciences, Giessen (Germany); Zink, K [Technische Hochschule Mittelhessen - University of Applied Sciences, Giessen (Germany); University Medical Center Giessen and Marburg, Marburg (Germany)

    2016-06-15

    Purpose: To validate the in-house developed CT Monte Carlo calculation tool GMctdospp against reference simulation sets provided by the AAPM in the new report 195. Methods: Deposited energy was calculated in four segments (test 1) and two 10 cm long cylinders (test 2) inside a CTDI phantom (following case #4 of the AAPM report 195). The x-ray point source of a given 120 kVp spectrum was collimated to a fan beam with two thicknesses (10 mm, 80 mm) for a static and a rotational setup. In addition, a given chest geometry was used to calculate deposited energy in several organs for a 0° static and a rotational beam (following case #5 of the AAPM report 195). The results of GMctdospp were compared against the particular mean value of the four quoted Monte Carlo codes (EGSnrc, Geant 4, MCNP and Penelope). Results: Calculated values showed no outliers in any of the cases. Differences between GMctdospp and the particular mean Results: Calculated values showed no outliers in any of the cases. Differences between GMctdospp and the particular mean value were always at similar magnitude compared to the quoted codes. For case #4 (CTDI phantom) the relative differences were within 1.5 %, on average 0.4 % and for case #5 (chest phantom) within 2.5 % and on average 0.85 %. Conclusion: The results confirmed an overall uncertainty of the Monte-Carlo calculation chain in GMctdospp being <2.5 %, for most cases even better. This can be considered small compared to other sources of uncertainties, e.g. virtual source and patient models. The photon transport implemented in GMctdospp inside a voxel-based patient geometry was successfully verified.

  9. Why American curriculum research could enrich Swiss curriculum stud-ies

    OpenAIRE

    Brühwiler Ingrid

    2016-01-01

    Implementing American curriculum research in another country is very problematic and frequently undesired because curriculum studies are complex as there are differences in terms history research approaches and political and social contexts. Nevertheless it is worthwhile to consider some North American curriculum theories as the findings lead to an enriching understanding of schools and hence of curricula and society. In this article William Pinar’s method of “currere” is explained to determ...

  10. 44 CFR 60.23 - Planning considerations for mudslide (i.e., mudflow)-prone areas.

    Science.gov (United States)

    2010-10-01

    ... standards for schools, hospitals, nursing homes, orphanages, correctional and other residential institutions...)-prone areas; (j) Deterring the nonessential installation of public utilities and public facilities in...

  11. Adapting to change : on the mechanism of type I-E CRISPR-Cas defence

    NARCIS (Netherlands)

    Künne, Tim A.

    2017-01-01

    Host-pathogen interactions are among the most prevalent and evolutionary important interactions known today. The predation of prokaryotes by their viruses is happening on an especially large scale and had a major influence on the evolutionary history of prokaryotes. Since most viruses are lytic

  12. Pictures of Industry and Industrial Work in Danish Art from the 1780ies till Today

    DEFF Research Database (Denmark)

    Abildgaard, Hanne

    2013-01-01

    Artiklen diskuterer, hvilke spor industrisamfundet har sat sig i dansk kunst gennem mere end 200 år. Den fokuserer på kunstnere, der bevidst har forholdt sig til industrisamfundets fænomener, og polemiserer i forlængelse heraf mod den opfattelse, at industrien er næsten totalt fraværende i dansk ...

  13. A neutron Albedo system with time rejection for landmine and IED detection

    Science.gov (United States)

    Kovaltchouk, V. D.; Andrews, H. R.; Clifford, E. T. H.; Faust, A. A.; Ing, H.; McFee, J. E.

    2011-10-01

    A neutron Albedo system has been developed for imaging of buried landmines and improvised explosive devices (IEDs). It involves irradiating the ground with fast neutrons and subsequently detecting the thermalized neutrons that return. A scintillating 6Li loaded ZnS(Ag) screen with a sensitive area of 40 cm×40 cm is used as a thermal neutron detector. Scintillation light is captured by orthogonal arrays of wavelength-shifting fibers placed on either side of the scintillator surface and then transferred to X and Y multi-pixel PMTs. A timing circuit, used with pulsed neutron sources, records the time when a neutron detection takes place relative to an external synchronization pulse from the pulsed source. Experimental tests of the Albedo system performance have been done in a sand box with a 252Cf neutron source (no time gating) and with pulsed D-D (2.6 MeV) neutrons from the Defense R&D Ottawa Van de Graaff accelerator (with time gating). Information contained in the time evolution of the thermal neutron field provided improved detection capability and image reconstruction. The detector design is described and experimental results are discussed.

  14. Ethiopia Pastoralist Areas Resilience Improvement and Market Expansion (PRIME) Project IE

    Data.gov (United States)

    US Agency for International Development — This baseline survey serves as the first stage of an impact evaluation designed to determine the impact of the project's interventions on households? resilience to...

  15. Engine fuel trends in the 90ies. Kraftstoff-Trends in den 90er Jahren

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, J.

    1990-06-01

    The operating behaviour of internal combustion engines is greatly dependent from the properties and compositions of the fuels. Increasing demands made on engine technology for improved cost-effectiveness, service life and pollutivity will result in greater demands on the vehicle fuel quality. A number of papers whose contents are briefly reported by the author, deal with today's requirements of the automative industry on vehicle fuels (table: characteristics, requirements, limits, comments) and with the prospects of alternative fuels. Another paper discussed the influence of the fuel on particulate emission by diesel engines. Another paper presented the calculation of physical fuel data from the carburettor substance analysis and its significance, the environmentally relevant effects of fuel additives in enginer, and optimized additive systems to meet greater quality demands on otto-engine fuels. (HWJ).

  16. Prof- dr. W . }. A ALDERS. P RO F. DR. PH. KOHNSTAMM EN D IE P ...

    African Journals Online (AJOL)

    Test

    indiwidualisme sterker by die Europese as by die Asiaticse mens. Sommige wil die wortels daarvan soek by die Griekse erfenis wat met die Renaissance meer ingedra is in die Weste. Ander vind dat bepaalde vorms van die Protestantisme juis indiwidualisme bevorder het. (vgl. Max Weber ,,The Ethics of Protestantism).

  17. Astronomy and Geology Vocabulary, I.e. "NASA Words" in Native American Languages

    Science.gov (United States)

    Angrum, A.; Alexander, C. J.; Martin, M.

    2014-12-01

    The US Rosetta Project has developed a program in Native American communities in which contemporary STEM vocabulary is taught alongside the same vocabulary in Navajo. NASA images and science are used and described in the native language, alongside both lay English, and scientific English. Additionally, science curriculum (geology/chemistry/botany/physics) elements drawn from the reservation environment, including geomorphology, geochemistry, soil physics, are included and discussed in the native language as much as possible — with their analogs in other planetary environments (such as Mars). The program began with a student defining 30 Navajo words to describe what he called 'NASA' words, such as: cell phone, astronaut, space suit, computer, and planets not visible to the naked eye. The use of NASA material and imagery have a positive impact on the accessibility of the overall STEM material but community involvement, and buy-in, is criti! cal to the success of the program. The US Rosetta Project modified its goals, and curriculum, to accommodate the programmatic desires of teachers in the district, and the capabilities of the medicine men that agreed to participate. In this presentation we will report on lessons learned, as well as metrics and successes associated with our most recent Summer Science Academy [2014].

  18. In RC buildings, the vertical and horizontal members (ie, the beams ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 4. Learning Earthquake Design and Construction - 18. How do Beams in RC Buildings Resist Earthquakes? C V R Murty. Classroom Volume 10 Issue 4 April 2005 pp 87-90 ...

  19. kant geveg het) aan sv lesers vaor Ie. Die deel sol" aFgesluit word ...

    African Journals Online (AJOL)

    come convinced that Communism wos the onlV possible instrument ForChino to cut cleanlv through to social justice and economic advance. Moo struggled Forthirtv Veors to establish 0 Com- munist state with almost another thirtv Veors of power to build Socialism in Chino. His desire to seek power and to hold it, destroved.

  20. Your Graduates and You: Effective Strategies for Graduate Recruitment and Development. IES Report.

    Science.gov (United States)

    Connor, H.; Hirsh, W.; Barber, L.

    Many employing organizations in the United Kingdom and elsewhere are finding it increasingly important to have an effective strategy for recruiting and developing higher education graduates. Numerous external and internal factors affect employers' graduate recruitment and development strategies. The following main approaches to graduates' entry…

  1. Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

    Science.gov (United States)

    Hayes, Robert P; Xiao, Yibei; Ding, Fran; van Erp, Paul B G; Rajashankar, Kanagalaghatta; Bailey, Scott; Wiedenheft, Blake; Ke, Ailong

    2016-02-25

    Clustered regularly interspaced short palindromic repeats (CRISPRs) and the cas (CRISPR-associated) operon form an RNA-based adaptive immune system against foreign genetic elements in prokaryotes. Type I accounts for 95% of CRISPR systems, and has been used to control gene expression and cell fate. During CRISPR RNA (crRNA)-guided interference, Cascade (CRISPR-associated complex for antiviral defence) facilitates the crRNA-guided invasion of double-stranded DNA for complementary base-pairing with the target DNA strand while displacing the non-target strand, forming an R-loop. Cas3, which has nuclease and helicase activities, is subsequently recruited to degrade two DNA strands. A protospacer adjacent motif (PAM) sequence flanking target DNA is crucial for self versus foreign discrimination. Here we present the 2.45 Å crystal structure of Escherichia coli Cascade bound to a foreign double-stranded DNA target. The 5'-ATG PAM is recognized in duplex form, from the minor groove side, by three structural features in the Cascade Cse1 subunit. The promiscuity inherent to minor groove DNA recognition rationalizes the observation that a single Cascade complex can respond to several distinct PAM sequences. Optimal PAM recognition coincides with wedge insertion, initiating directional target DNA strand unwinding to allow segmented base-pairing with crRNA. The non-target strand is guided along a parallel path 25 Å apart, and the R-loop structure is further stabilized by locking this strand behind the Cse2 dimer. These observations provide the structural basis for understanding the PAM-dependent directional R-loop formation process.

  2. Engineering of methionine chain elongation part of glucoraphanin pathway in <i>E. coli

    DEFF Research Database (Denmark)

    Mirza, Nadia Muhammad Akram; Crocoll, Christoph; Olsen, Carl Erik

    2016-01-01

    The methionine-derived glucosinolate glucoraphanin is associated with the health-promoting properties of broccoli. This has developed a strong interest in producing this compound in high amounts from a microbial source. Glucoraphanin synthesis starts with a five-gene chain elongation pathway...

  3. D IE ROOM SE LUTHER SE EN HERVORMDEB ESK OU IN ...

    African Journals Online (AJOL)

    Test

    Oor die leerstuk van die heilige Avondmaal neem Luther 'n tussen- standpunt in tussen die Roomse Kerk en die Hervormde Kerk. W aar. Rome leer dat die brood en die wyn by die bediening van die Avond maal waarlik in die vlees en bloed van Christus verander word, sodat die Avondmaalganger waarlik die liggaam van ...

  4. Evidence-based Nursing in the IED: From Caring to Curing?

    Directory of Open Access Journals (Sweden)

    Jette Ernst

    2016-03-01

    Full Text Available Danish hospitals are major sites of healthcare reform, and new public management accountability and performance management tools have been applied to improve the quality and efficiency of services. One consequence of this is that nurses’ work in hospitals is increasingly standardized through medical evidence. Using Bourdieu’s theory of practice in combination with an ethnographic field study, it is analyzed how the nurses of a Danish Integrated Emergency Department respond to the changing conditions of work. It is illuminated how two opposing approaches to nursing of humanistically and pluralistically oriented caring, and evidence-based scientifically oriented curing inform nursing in the department. The curing approach is however trumping the caring approach. Curing creates new nursing career pathways and is by some nurses embraced with enthusiasm. For others, the new situation creates tension and distress. It is illustrated how the nurses position their practice in relation to the changing working conditions taking sides for either curing or caring, or finding a way to maneuver in between the two. The article argues that the normative enforcement of the curing approach may carry unintended side effects to the goals of quality and efficiency enhancements.

  5. Dragon’s Claws: The Improvised Explosive Device (IED) as a Weapon of Strategic Influence

    Science.gov (United States)

    2009-03-01

    admiration, respect, regret, sadness, guilt, and even anguish. They emotionally prepared themselves for loading their friends’ flag- draped coffins...including attacks on armoured vehicles, outposts and helicopters.164 AQI certainly has not limited its operations to the guidelines of Zarqawi’s letter...reports of American casualties, glimpses of flag- draped coffins, and stories of towns rallying behind the families of their fallen heroes accumulate in

  6. A Standardized Procedure for a Pre-evaluation of the IED Instance

    Science.gov (United States)

    Panepinto, Deborah; Ruffino, Barbara; Zanetti, Mariachiara; Genon, Giuseppe

    2016-04-01

    This study presents a procedure, called EICS (Enterprise IPPC Compatibility Study) aimed at evaluating, by means of the calculation of three indexes, the compliance of the processes performed in an industrial plant with the guidelines provided by BREFs (BAT References) Documents. In fact, according to European Directive 2010/75/EU (concerning the Integrated Pollution Prevention and Control and repealing European Directive 2008/01/EC), industrial plants must require authorizations to the competent authority stating the conformity of their activity, in order to obtain this conformity they are advised to Best Available Technologies (BAT). The aim of the BATs is to avoid or minimize the impact of an industrial activity on the environment through the prevention of the atmospheric emissions, wastewater discharge and energetic consumption, and the correct waste management thus improving the efficiency of the plant. The procedure shown in the present paper has been tested on several types of industrial plant (cement plants, secondary smelt foundries, paper-mill, and automotive industries as regards their paint lines). In this paper, the application of EICS method to a cement plant is presented: the obtained results highlight a good correlation between the index values and the real situation of the plant.

  7. The Optimal Taxation of UnskilIed Labor with Job Search and Social Assistance

    NARCIS (Netherlands)

    Boone, J.; Bovenberg, A.L.

    2002-01-01

    In order to explore the optimal taxation of low-skilled labor, we extend the standard model of optimal non-linear income taxation in the presence of quasi-linear preferences in leisure by allowing for involuntary unemployment, job search, an exogenous welfare benefit, and a non-utilitarian social

  8. Keliolika pastabų apie lietuviškuosius liberalizmo tapatumo ieškojimus

    OpenAIRE

    Narbutaitė, Nijolė

    2006-01-01

    The reviewed collection of articles Alvydas Jokubaitis. Liberalizmo tapatumo problemos (Problems of liberalism identity). Vilnius: Versus aureus, 2003. 239 p. It is the second collection of articles by this author dedicated to the philosophical issues of liberalism. The article contains the meaningful emphasises without leading away from the main idea – the problems of liberalism, by describing them in various aspects of the liberalism history and contemporary problems of liberalism. Complica...

  9. INVESTIGAREA CRIMINALISTICĂ A LOCULUI FAPTEI IN CAZUL INFRACŢIUNILOR DE CORUPŢIE

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2007-05-01

    Full Text Available In this work,I’ve presented the meaning of corruption offences,which is corruption sense for romanian state.The criminalistica investigation will be done,regularity,at the beginning of penal pursuance,for knowledge ofoffences accomplishment.Also,we can tell this activity is expanding,distinctive, during the examination ofcriminal place.Should be discussed the following thing:if in most cases of offences,such manslaughter,theexamination of criminal place is often realized for identify offender,but when we speak about the corruptionoffences,the criminalistica investigation has hinted at offender for establish the action.The romanian penal law is anticipate some substantial and formal conditions looking for the criminalisticainvestigation.As regards this examination,are taken preparatory measures at the judicial offices,and also,at thecriminal place;the examination team are organized with suitable technical and scientific means.In accordance with nature of facts,commited place,or after-effects,these teams are includedprosecutors,criminalist,officer of judicial police,experts from technical area,but the activity sovereign is theprosecutor.Also,the assistant witness has an important role in this activity,and he hadn’t any involve in respectivecause.Finally,the issues of investigation are materialized and described in a record.

  10. Why Understanding Science Matters: The IES Research Guidelines as a Case in Point

    Science.gov (United States)

    Rudolph, John L.

    2014-01-01

    The author outlines the rise of a hard-science model advocated by the Institute for Education Sciences, including the application of research and development approaches to education following the Second World War, and describes the attraction of these hard-science approaches for education policymakers. He notes that in the face of complex and…

  11. The Effect of Pretreatment on the Cesium Adsorption Ability of IONSIV(C)IE-911

    International Nuclear Information System (INIS)

    Fondeur, F.F.

    1999-01-01

    The recovery of plutonium from reactor fuel elements at the Savannah River Site generated nearly 34 million gallons of high level waste. The Site stores the waste as a mixture of precipitated metal hydroxides and associated supernatant liquid with elevated concentrations of free hydroxide. The liquid fraction contains the majority of the radioactive cesium

  12. Diet of the cyprinid fish Barbus aeneus (Burchell) in the P .K. Ie Roux ...

    African Journals Online (AJOL)

    structure of the ecosystem, and fail to take into account ... by restricting photosynthesis but also, by restricting solar ... radiation and evaporation, and contributed to the generally .... Autumn (March - May) - negative heat balance, stratifIca-.

  13. Physical Education Initial Teacher Educators' Expressions of Critical Pedagogy(ies): Coherency, Complexity or Confusion?

    Science.gov (United States)

    Philpot, Rod

    2016-01-01

    While an emphasis on social justice has emerged as a theme in initial teacher education (ITE) over the past decade, there is much debate about how to engage ITE students in foregrounding issues of equity and social justice in their own teaching. One strategy, the introduction of critical pedagogy in ITE, has been promoted in teacher education…

  14. Hydrogen: it's now. Hydrogen, essential today, indispensable tomorrow. Power-to-Gas or how to meet the challenge of electricity storage. To develop hydrogen mobility. Hydrogen production modes and scope of application of the IED directive - Interview. Regulatory evolutions needed for an easier deployment of hydrogen energy technologies for a clean mobility. Support of the Community's policy to hydrogen and to fuel cells

    International Nuclear Information System (INIS)

    Mauberger, Pascal; Boucly, Philippe; Quint, Aliette; Pierre, Helene; Lucchese, Paul; Bouillon-Delporte, Valerie; Chauvet, Bertrand; Ferrari, Fabio; Boivin, Jean-Pierre

    2015-01-01

    Published by the French Association for Hydrogen and Fuel Cells (AFHYPAC), this document first outlines how hydrogen can reduce our dependence on fossil energies, how it supports the development of electric mobility to reduce CO 2 emissions by transports, how it enables a massive storage of energy as a support to renewable energies deployment and integration, and how hydrogen can be a competitiveness driver. Then two contributions address technical solutions, the first one being Power-to-Gas as a solution to energy storage (integration of renewable energies, a mean for massive storage of electricity, economic conditions making the first deployments feasible, huge social and economical benefits, necessity of creation of an adapted legal and economic framework), and the second one being the development of hydrogen-powered mobility (a major societal concern for air quality, strategies of car manufacturers in the world, necessity of a favourable framework, the situation of recharging infrastructures). Two contributions address the legal framework regarding hydrogen production modes and the scope of application of the European IED directive on industrial emissions, and the needed regulatory evolutions for an easier deployment of Hydrogen-energy technologies for a clean mobility. A last article comments the evolution of the support of European policies to hydrogen and fuel cells through R and d programs, presents the main support program (FCH JU) and its results, other European financing and support policy, and discusses perspectives, notably for possible financing mechanisms

  15. (Multiletramento(s digital(is e teoria do posicionamento: análise das práticas discursivas de professoras que se relacionaram com as tecnologias da informação e comunicação no ensino público Digital (multiliteracy(ies and positioning theory: analysis of discursive practices of teachers involved with information and communication technologies in the public education

    Directory of Open Access Journals (Sweden)

    Fabiano Santos Saito

    2012-01-01

    ítica e questionadora desses contextos educacionais, considerando a formação docente como essencial para a apropriação e o uso situado das TICs. Também é nosso intento levantar discussões transdisciplinares nas áreas de Linguística, Ensino e Tecnologia.The aim of this work is to analyze the discursive practices of three teachers involved both direct and indirectly with Information and Communication Technologies (ICTs in the teaching-learning process of a public school situated in the city of Juiz de Fora - State of Minas Gerais in Brazil. To accomplish our goal, we used the theoretical model of Digital Multiliteracies (SELBER, 2004, regarding the uses and social practices of Digital Era. To enrich the analyses of this study, we also brought the theoretical contributions of Positioning Theory (HARRÉ; VAN LANGENHOVE, 1999, in order to understand how teachers take positions within a teaching context that uses digital technologies. This is a qualitative-interpretivist research methodologically set as ethnographic case study allied to a discourse analysis. The results points that, although in a first moment all the teachers take a technophile position (i.e., a position in favor of use of ICTs in educational environment, this position is rejected by some teachers indirectly involved with Computer Lab in later positionings (discursive positions takings, in which it is possible to identify technophobic positions (fear or resistance to digital technologies, that are indices of lack of teacher training oriented for more effective and situated use of ICTs in classrooms. Furthermore, the positions and positionings taken by teachers indicate a Functional Digital Literacy model in the school investigated, which is motivated by informational infrastructure troubles and institutional forces from social instances above the school. One of theoretic-methodological contributions of this study is to relate the Position Theory to the model of Digital Multiliteracies to explain the

  16. (Multiletramento(s digital(is e teoria do posicionamento: análise das práticas discursivas de professoras que se relacionaram com as tecnologias da informação e comunicação no ensino público Digital (multiliteracy(ies and positioning theory: analysis of discursive practices of teachers involved with information and communication technologies in the public education

    Directory of Open Access Journals (Sweden)

    Fabiano Santos Saito

    2013-03-01

    ítica e questionadora desses contextos educacionais, considerando a formação docente como essencial para a apropriação e o uso situado das TICs. Também é nosso intento levantar discussões transdisciplinares nas áreas de Linguística, Ensino e Tecnologia.The aim of this work is to analyze the discursive practices of three teachers involved both direct and indirectly with Information and Communication Technologies (ICTs in the teaching-learning process of a public school situated in the city of Juiz de Fora - State of Minas Gerais in Brazil. To accomplish our goal, we used the theoretical model of Digital Multiliteracies (SELBER, 2004, regarding the uses and social practices of Digital Era. To enrich the analyses of this study, we also brought the theoretical contributions of Positioning Theory (HARRÉ; VAN LANGENHOVE, 1999, in order to understand how teachers take positions within a teaching context that uses digital technologies. This is a qualitative-interpretivist research methodologically set as ethnographic case study allied to a discourse analysis. The results points that, although in a first moment all the teachers take a technophile position (i.e., a position in favor of use of ICTs in educational environment, this position is rejected by some teachers indirectly involved with Computer Lab in later positionings (discursive positions takings, in which it is possible to identify technophobic positions (fear or resistance to digital technologies, that are indices of lack of teacher training oriented for more effective and situated use of ICTs in classrooms. Furthermore, the positions and positionings taken by teachers indicate a Functional Digital Literacy model in the school investigated, which is motivated by informational infrastructure troubles and institutional forces from social instances above the school. One of theoretic-methodological contributions of this study is to relate the Position Theory to the model of Digital Multiliteracies to explain the

  17. Kes tahab elada raudtee ääres? : kortermajad Õie tn. 2 Nõmmel = WhoWants to Live Next to the Railway? : apartment buildings Õie St. 2 in Nõmme / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2005-01-01

    Kolm viie korteriga kolmekorruselist korterelamut. Projekteerija: Arhitektuuribüroo Pluss. Autor Indrek Allmann. Konstruktsioonid: E-Inseneribüroo. Detailplaneering: Koot & Koot. Projekt: 2003, valmis: 2005. Ill.: katusekorruse ja tüüpkorruse plaan, 5 värv. välisvaadet

  18. MO-FG-CAMPUS-IeP1-03: Establishment of Provincial Diagnostic Reference Levels in Pediatric Imaging

    International Nuclear Information System (INIS)

    Tonkopi, E; O’Brien, K

    2016-01-01

    Purpose: To establish provincial diagnostic reference levels (DRLs) in pediatric general radiography and computed tomography (CT) as a tool for the optimization of exposure parameters. Methods: Patient dose survey was conducted in the only pediatric hospital in the province of Nova Scotia. The DRLs were established as the 75th percentile of patient dose distributions in different age groups. For routine radiography projections the DRLs were determined in terms of entrance surface dose (ESD) calculated from the radiation output measurements and the tube current-exposure time product (mAs) recorded for each examination. Patient thickness was measured by the technologist during the examination. The CR and DR systems, employing respectively a fixed technique and phototiming, were evaluated separately; a two-tailed Student’s t-test was used to determine the significance of differences between the means of dose distributions. The CT studies included routine head, chest, abdomen/pelvis, and chest/abdomen/pelvis. The volume CT dose index (CTDIvol) and dose-length product (DLP) values were extracted retrospectively from PACS. The correction factors based on the effective diameter of the patient were applied to the CT dosimetry metrics based on the standard phantoms. Results: The provincial DRLs were established in the following age groups: newborn, 1, 5, 10, and 15 year olds. In general radiography the DR systems demonstrated slightly lower dose than the CR for all views, however the differences were not statistically significant (p > 0.05) for all examinations. In CT the provincial DRLs were lower than the published data, except for head DLPs in all age categories. This might be due to the small patient sample size in the survey. Future work will include additional CT data collection over an extended period of time. Conclusion: Provincial DRLs were established in the dedicated children’s hospital to provide guidance for the other facilities in examinations of pediatric patients.

  19. 44 CFR 60.4 - Flood plain management criteria for mudslide (i.e., mudflow)-prone areas.

    Science.gov (United States)

    2010-10-01

    ... the Federal Insurance Administrator which (i) regulates the location of foundation systems and utility... protective measures including but not necessarily limited to retaining walls, buttress fills, sub-drains...

  20. Show your best self(ie) : An exploratory study on selfie-related motivations and behavior in emerging adulthood

    NARCIS (Netherlands)

    Bij de Vaate, Anna J.D.(Nadia); Veldhuis, Jolanda; Alleva, Jessica M.; Konijn, Elly A.; van Hugten, Charlotte H.M.

    2018-01-01

    Although self-presentation has been studied for decades, social networking sites (SNS) such as Facebook have produced novel opportunities for visual online self-presentation. Posting selfies is currently a popular mode of consciously constructing visual online self-presentations, yet most prior

  1. Pile/shaft designs using artificial neural networks (i.e., genetic programming) with spatial variability considerations.

    Science.gov (United States)

    2014-03-01

    The work focused on the improvement of FB-DEEPs prediction of skin and tip resistance of concrete : piles and drilled shafts in Florida. For the work, data from 19 concrete pile sites and 18 drilled shaft sites were : collected. This included 458 ...

  2. Pile/shaft designs using artificial neural networks (i.e., genetic programming) with spatial variability considerations : [summary].

    Science.gov (United States)

    2014-03-01

    In this project, University of Florida researchers : sought to improve the unit skin friction and tip : resistance correlations embedded in the FB-Deep : software algorithm for estimating driven pile and : drilled shaft resistance. They utilized an a...

  3. IE Information Notice No. 85-08: Industry experience on certain materials used in safety-related equipment

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    This information notice is being issued to provide licensees and construction permit holders with information pertaining to the behavior of certain materials used in safety-related equipment. The materials, as described below, were observed to have the potential of degrading the operability of safety-related equipment. These observations were made during environmental qualification testing and/or during routine inspection of in-service equipment. The notice describes the following: elastomeric seals used in personnel air locks for the reactor containment systems; epoxy phenolic coating applied to the lower portion of the interior surface of diesel oil storage tanks; the use of Viton elastomer as the seal material in hydrogen recombiner applications; and environmental qualification of ASCO NP valves with Viton and ethylene propylene parts

  4. 4rtikel 33 a v4~ i)ie regle~e~tv4~ i)issi()l

    African Journals Online (AJOL)

    Regtens is hierdie veronderstelling foutief en ongegrond. Die misdryf kan ook gepleeg word deur te veel narkotiese of bedwelmende middels anders as alkoholiese drank in te neem, hetsy per mond, deur inaseming of deur inspuitings. Dit sluit dus dagga, opium, luminaal, LSD en middels wat 'n dergelike uitwerking op die.

  5. [The effect of ivermectin on geohelminth frequency (i.e. as used in the onchocerciasis control program in Colombia)].

    Science.gov (United States)

    Knudson, Angélica; Ariza, Yoseth; López, Myriam C; Fajardo, Oscar S; Reyes, Patricia; Moncada, Ligia I; Duque, Sofía; Álvarez, Carlos A; Nicholls, Rubén S

    2012-08-01

    Evaluating the effect of ivermectin on soil-transmitted helminthes (STH) infection frequency in a Colombian population included in the Onchocerciasis Elimination Program for the Americas (OEPA). This was an impact evaluation study which adopted a longitudinal approach using the population of Naicioná (1996) as baseline for comparison to people from the same population as controls (2008). The cross-sectional approach involved comparing the reference population of Naicioná (2008) to the population of Dos Quebradas (2008) used as controls. Fecal samples were processed by a modified Ritchie-Frick method. Ascaris lumbricoides was the most frequently found parasite in Naicioná (60/121; 49.6 %: 37.8-63.895%CI) and in Dos Quebradas (36/76; 47.4 %: 33.2-65.6 95 % CI). Ivermectin's main effect on the population aged over 5 years was a decreased risk of Trichiuris trichiura infection in both longitudinal assessment (86 % reduction: 74-93 95 % CI) and cross-sectional assessment (63 %:24-82 95 % CI). A 93 % reduction (45-99 95 % CI) in Strongyloides stercoralis frequency was found in longitudinal assessment, compared to 85 % in cross-sectional assessment (-031-99 95 % CI). Ivermectin use in the OEPA is not sufficient for STH morbidity control. Integrated programs including education and basic sanitation are required.

  6. Exposure of the Bulgarian population from natural and manmade ionizing radiation sources in the mid 90-ies

    International Nuclear Information System (INIS)

    Vasilev, G.; Bajrakova, A.; Ingilizova, Kh.; Khristova, M.; Karadzhov, A.

    1997-01-01

    The main radiation sources the Bulgarian population is exposed to, e.g. natural radiation background and manmade exposure such as occupational, medical, nuclear power engineering and the like, are analyzed. The study covers the period 1991-1994 but it also contains a number of retrospective assessments concerning the last few decades. It is prepared with a special reference to the forthcoming report of the United Nations Scientific Committee on the effect of atomic radiation scheduled for publication in 1998/1999. The Bulgarian population exposure presented as average annual effective collective doses amounts to 20240 mSv/a from natural background, 6400 mSv/a from x-ray diagnostics, 400 mSv/a from nuclear medicine, 17 mSv/a from occupational exposure (uranium mining excluded) etc. Total exposure in excess to background irradiation is about 40% of the background one

  7. ,t'.: O.)IISPIIONG EN ONTWIKKELIN •• VAN ItIE ONDERRI ••F'LM

    African Journals Online (AJOL)

    4. Die onderrigfilms wat vir skole bestaan het, het aspekte soos verhale, tegniese vakke, geografie, geskiedenis, taal en higiene gedek. Bogenoemde films was egter baie beperk in terme van opvoedkundige waarde aangesien dit bestaan het uit materiaal wat vanaf kommersiele films afkomstig was en later aangepas is Die.

  8. IED Campaign in the U.S. Homeland: Are U.S. Military EOD Units Prepared to Respond

    Science.gov (United States)

    2017-06-09

    detonate on the second day of a weeklong outdoor music festival in a suburb of a major metropolitan city killing several people and wounding over one...vicinity of the festival have been identified as containing suspicious items inside by responding law enforcement. 3. Local authorities establish an ICP...near the site of the festival and begin to activate mutual support agreements with other local jurisdictions for additional emergency response

  9. TU-H-CAMPUS-IeP2-01: Quantitative Evaluation of PROPELLER DWI Using QIBA Diffusion Phantom

    Energy Technology Data Exchange (ETDEWEB)

    Yung, J; Ai, H; Liu, H; Stafford, R [The University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: The purpose of this study is to determine the quantitative variability of apparent diffusion coefficient (ADC) values when varying imaging parameters in a diffusion-weighted (DW) fast spin echo (FSE) sequence with Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) k-space trajectory. Methods: Using a 3T MRI scanner, a NIST traceable, quantitative magnetic resonance imaging (MRI) diffusion phantom (High Precision Devices, Inc, Boulder, Colorado) consisting of 13 vials filled with various concentrations of polymer polyvinylpyrrolidone (PVP) in aqueous solution was imaged with a standard Quantitative Imaging Biomarkers Alliance (QIBA) DWI spin echo, echo planar imaging (SE EPI) acquisition. The same phantom was then imaged with a DWI PROPELLER sequence at varying echo train lengths (ETL) of 8, 20, and 32, as well as b-values of 400, 900, and 2000. QIBA DWI phantom analysis software was used to generate ADC maps and create region of interests (ROIs) for quantitative measurements of each vial. Mean and standard deviations of the ROIs were compared. Results: The SE EPI sequence generated ADC values that showed very good agreement with the known ADC values of the phantom (r2 = 0.9995, slope = 1.0061). The ADC values measured from the PROPELLER sequences were inflated, but were highly correlated with an r2 range from 0.8754 to 0.9880. The PROPELLER sequence with an ETL=20 and b-value of 0 and 2000 showed the closest agreement (r2 = 0.9034, slope = 0.9880). Conclusion: The DW PROPELLER sequence is promising for quantitative evaluation of ADC values. A drawback of the PROPELLER sequence is the longer acquisition time. The 180° refocusing pulses may also cause the observed increase in ADC values compared to the standard SE EPI DW sequence. However, the FSE sequence offers an advantage with in-plane motion and geometric distortion which will be investigated in future studies.

  10. SU-G-IeP4-15: Ultrasound Imaging of Absorbable Inferior Vena Cava Filters for Proper Placement

    Energy Technology Data Exchange (ETDEWEB)

    Mitcham, T; Bouchard, R; Melancon, A; Melancon, M [University of Texas MD Anderson Cancer Center, Houston, TX (United States); Eggers, M [Adient Medical Technologies, Pearland, TX (United States)

    2016-06-15

    Purpose: Inferior vena cava filters (IVCFs) are used in patients with a high risk of pulmonary embolism in situations when the use of blood thinning drugs would be inappropriate. These filters are implanted under x-ray guidance; however, this provides a dose of ionizing radiation to both patient and physician. B-mode ultrasound (US) imaging allows for localization of certain implanted devices without radiation dose concerns. The goal of this study was to investigate the feasibility of imaging the placement of absorbable IVCFs using US imaging to alleviate the dosage concern inherent to fluoroscopy. Methods: A phantom was constructed to mimic a human IVC using tissue-mimicking material with 0.5 dB/cm/MHz acoustic attenuation, while agar inclusions were used to model acoustic mismatch at the venous interface. Absorbable IVCF’s were imaged at 15 cm depth using B-mode US at 2, 3, 5, and 7 MHz transmit frequencies. Then, to determine temporal stability, the IVCF was left in the phantom for 10 weeks; during this time, the IVCF was imaged using the same techniques as above, while the integrity of the filter was analyzed by inspecting for fiber discontinuities. Results: Visualization of the inferior vena cava filter was possible at 5, 7.5, and 15 cm depth at US central frequencies of 2, 3, 5, and 7 MHz. Imaging the IVCF at 5 MHz yielded the clearest images while maintaining acceptable spatial resolution for identifying the IVCF’s, while lower frequencies provided noticeably worse image quality. No obvious degradation was observed over the course of the 10 weeks in a static phantom environment. Conclusion: Biodegradable IVCF localization was possible up to 15 cm in depth using conventional B-mode US in a tissue-mimicking phantom. This leads to the potential for using B-mode US to guide the placement of the IVCF upon deployment by the interventional radiologist. Mitch Eggers is an owner of Adient Medical Technologies. There are no other conflicts of interest to disclose.

  11. Seismic response analysis of soil-structure interactive system using a coupled three-dimensional FE-IE method

    International Nuclear Information System (INIS)

    Ryu, Jeong-Soo; Seo, Choon-Gyo; Kim, Jae-Min; Yun, Chung-Bang

    2010-01-01

    This paper proposes a slightly new three-dimensional radial-shaped dynamic infinite elements fully coupled to finite elements for an analysis of soil-structure interaction system in a horizontally layered medium. We then deal with a seismic analysis technique for a three-dimensional soil-structure interactive system, based on the coupled finite-infinite method in frequency domain. The dynamic infinite elements are simulated for the unbounded domain with wave functions propagating multi-generated wave components. The accuracy of the dynamic infinite element and effectiveness of the seismic analysis technique may be demonstrated through a typical compliance analysis of square surface footing, an L-shaped mat concrete footing on layered soil medium and two kinds of practical seismic analysis tests. The practical analyses are (1) a site response analysis of the well-known Hualien site excited by all travelling wave components (primary, shear, Rayleigh waves) and (2) a generation of a floor response spectrum of a nuclear power plant. The obtained dynamic results show good agreement compared with the measured response data and numerical values of other soil-structure interaction analysis package.

  12. SU-G-IeP2-09: Iodine Imaging at Spectral CT with a Dual-Layer Detector

    Energy Technology Data Exchange (ETDEWEB)

    Ozguner, O [Case Western Reserve University, Cleveland, Ohio (United States); Dhanantwari, A; Halliburton, S; Utrup, S [Philips Healthcare, Highland Heights, OH (United States); Wen, G [The University of Texas at Austin, Austin, TX (United States); Jordan, D [University Hospitals Case Medical Center, Cleveland, OH (United States)

    2016-06-15

    Purpose: To evaluate the attenuation response of iodine and the accuracy of iodine quantification on a detector-based spectral CT scanner. Methods: A Gammex 461A phantom was scanned using a dual-layer detector (IQon, Philips) at 120 kVp using helical acquisition with a CDTIvol of 15 mGy to approximate the hospital’s clinical body protocol. No modifications to the standard protocol were necessary to enable spectral imaging. Iodine inserts at 6 concentrations (2, 5, 7.5, 10, 15, 20 mg/ml) were scanned individually at the center of the phantom and the 20 mg/ml insert was additionally scanned at the 3, 6, and 12 o’clock positions. Scans were repeated 10 times. Conventional, virtual monoenergetic (40–200 keV) and iodine-no-water images (with pixel values equal to iodine concentration of corresponding tissue) were reconstructed from acquired data. A circular ROI (diameter=30 pixels) was used in each conventional and monoenergetic image to measure the mean and standard deviation of the CT number in HU and in each iodine-no-water image to measure iodine concentration in mg/ml. Results: Mean CT number and contrast-to-noise ratio (CNR) measured from monoenergetic images increased with decreasing keV for all iodine concentrations and matched measurements from conventional images at 75 keV. Measurements from the 20 ml insert showed the CT number is independent of location and CNR is a function only of noise, which was higher in the center. Measured concentration from iodine-no-water images matched phantom manufacturer suggested concentration to within 6% on average for inserts at the center of the phantom. Measured concentrations were systematically higher due to optimization of iodine quantification parameters for clinical mixtures of iodine and blood/tissue. Conclusion: Spectral acquisition and reconstruction with a dual-layer detector represents the physical behavior of iodine as expected and accurately quantifies the material concentration. This should permit a variety of clinical applications including lesion characterization, vessel patency, and myocardial perfusion. This study was performed as part of a research agreement among Philips Healthcare, University Hospitals of Cleveland, and Case Western Reserve University.

  13. Migration of longlived transuranium isotopes (i.e. Pu-239, Am-241) in the soil and in geological formations

    International Nuclear Information System (INIS)

    Jakubick, A.; Dippel, T.

    1977-01-01

    From an undisturbed site, soil samples were taken for Pu-239,240 analysis. Each sample represented a 2 cm thick layer. The Pu-239 distribution pattern was analysed by checking to a computer model. The mean residence time tau was used as a transport parameter in the model. The validity of tau was proved by comparing the calculated contamination values with the measured amount of contamination in the field. The migration velocity of the 50% of PuO 2 contamination at the investigated loess loamy site was calculated to be vsub(PuO2) = 0.59 cm/a. In the vicinity of the Pu-sampling site HTO-tracer experiments indicated an average water percolation velocity of vsub(HTO) = 100 cm/a. From these values a dimensionless relative PuO 2 migration velocity. vsub(r(PuO2)) = vsub((PuO2))/vsub(HTO) = 5.9 x 10 -3 followed. (orig./RW) [de

  14. The Study on Neuro-IE Management Software in Manufacturing Enterprises. -The Application of Video Analysis Technology

    Science.gov (United States)

    Bian, Jun; Fu, Huijian; Shang, Qian; Zhou, Xiangyang; Ma, Qingguo

    This paper analyzes the outstanding problems in current industrial production by reviewing the three stages of the Industrial Engineering Development. Based on investigations and interviews in enterprises, we propose the new idea of applying "computer video analysis technology" to new industrial engineering management software, and add "loose-coefficient" of the working station to this software in order to arrange scientific and humanistic production. Meanwhile, we suggest utilizing Biofeedback Technology to promote further research on "the rules of workers' physiological, psychological and emotional changes in production". This new kind of combination will push forward industrial engineering theories and benefit enterprises in progressing towards flexible social production, thus it will be of great theory innovation value, social significance and application value.

  15. TU-H-CAMPUS-IeP3-04: Evaluation of Changes in Quantitative Ultrasound Parameters During Prostate Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Najafi, M; El Kaffas, A; Han, B [Department of Radiation Oncology, Stanford University, Palo Alto, CA (United States); Cooper, D [Elekta Inc., Montreal, QC (Canada); Hancock, S; Hristov, D

    2016-06-15

    Purpose: Clarity Autoscan ultrasound monitoring system allows acquisition of raw radiofrequency (RF) ultrasound data prior and during radiotherapy. This enables the computation of 3D Quantitative Ultrasound (QUS) tissue parametric maps from. We aim to evaluate whether QUS parameters undergo changes with radiotherapy and thus potentially be used as early predictors and/or markers of treatment response in prostate cancer patients. Methods: In-vivo evaluation was performed under IRB protocol to allow data collection in prostate patients treated with VMAT whereby prostate was imaged through the acoustic window of the perineum. QUS spectroscopy analysis was carried out by computing a tissue power spectrum normalized to the power spectrum obtained from a quartz to remove system transfer function effects. A ROI was selected within the 3D image volume of the prostate. Because longitudinal registration was optimal, the same features could be used to select ROIs at roughly the same location in images acquired on different days. Parametric maps were generated within the rectangular ROIs with window sizes that were approximately 8 times the wavelength of the ultrasound. The mid-band fit (MBF), spectral slope (SS) and spectral intercept (SI) QUS parameters were computed for each window within the ROI and displayed as parametric maps. Quantitative parameters were obtained by averaging each of the spectral parameters over the whole ROI. Results: Data was acquired for over 21 treatment fractions. Preliminary results show changes in the parametric maps. MBF values decreased from −33.9 dB to −38.7 dB from pre-treatment to the last day of treatment. The spectral slope increased from −1.1 a.u. to −0.5 a.u., and spectral intercept decreased from −28.2 dB to −36.3 dB over the 21 treatment regimen. Conclusion: QUS parametric maps change over the course of treatment which warrants further investigation in their potential use for treatment planning and predicting treatment outcomes. Research was supported by Elekta.

  16. Studying the pollution of Barada river environment with poisonous elements resulting from leather industry (i.e. tanning industry)

    International Nuclear Information System (INIS)

    Khamis, I.; Al-Masri, M.S.; Sarheel, A.; Al-Somel, N.

    2000-07-01

    The impact of tanning and electroplating industry on the eastern part of Barada river environment has been evaluated. Sediment, soil and plant samples were collected from nine sites at the river near the eastern industrial complex during 1999. Results of instrumental neutron activation analysis have shown high levels of chrome in sediment collected near the tanning factories; the highest value obtained being 2692 ppm. In addition, relatively high levels of Cr were also found in the agriculture soil collected near the riverbank in the industrial complex; Cr concentrations in plant leaves grown at riverbank were found low and this due strong bounding of Cr to soil. Other trace metals such as copper was about 4000 ppm, which is much higher than the natural levels; electroplating shops are the main source of this element in the area. Furthermore, concentrations of the studied trace metals have decreased as the elements were found to be at low concentrations, but the obtained data can be used as a baseline for future monitoring. (Author)

  17. Tio Ie Soei Dan Nona Tjoe Joe (Pertjinta'an Jang Membawa Tjilaka: Tegangan Antara Konservatif dan Modern

    Directory of Open Access Journals (Sweden)

    Dwi Susanto

    2009-12-01

    Full Text Available Nona Tjoe (Pertjinta'an Jang membawa Tjilaka adalah sebuah cerita yang berbeda dari pcngarang ccrita peranakan China pada era 1920. Cerita ini juga memberikan karakteristik yang berbeda dari cerita-cerita Tio le Soci. Tulisan ini bertujuan untuk mengeksplorasi dan mcnjclaskan keadaan kehidupan sosial masyarakat/komunitas China yang ter-refleksi dalam Nona Tjoe Joe. Dengan memfokuskan pada representasi kehidupan komunitas China, tulisan ini berusaha mcnjawab beberapa pertanyaan "dimanakah kita sekarang dan apa yang terjadi dengan kehidupan kita sekarang dan akan datang" (2 bagaimana masyarakat China merespon pengaruh Barat (3 dengan analogi posisi wanita, seperti apa pilihan identitas peranakan China. Untuk menjawab pertanyaan itu, artikel ini memfokusukan pada teks sebagai refleksi fakta sosial. Kemudian, refleksi itu dianggap sebagai fakta kemanusian seperti perasaan, identitas, strategi untuk. bertahan hidup masyarakat China Abstract: Nona Tjoe Joe (Pertjinta 'an Jang membawa Tjilaka is a different story compared to other peranakan Chinese stories in 1920 era. This story also gives the characteristic different from the other Tio le Soe.i stories, The study aims to explore and explain the condition of social life of Chinese community as reflected in Nona Tjoe Joe story. Giving the focus on the representation of the Chinese life, this article attempts to give answers of t.hc following questions: (1 how did Chinese community give answer "where is now and what happen with our present time and future", (2 how did Chinese community responds to the West influence, (3 with analogy of women position, what was the choices of identity peranakan Chinese. To answer those questions, this article gives the focus on the text as a reflection of social facts. The reflection is considered as human fact of feeling. identity, strategy to defending life of Chinese community. Keywords: reflection Chinese community, conservatism, modem

  18. Immigration Policy of Spain in the Context of Problems of Ceuta and Melilla in the 90-ies of XX century

    Directory of Open Access Journals (Sweden)

    E V Salamov

    2014-12-01

    Full Text Available This article analyzes the migration policy of Spain in the context of immigration processes from Morocco through the autonomous cities of Ceuta and Melilla, which are the territory of the European Union. The problem of immigration to the cities is one of the most serious in the relationship between the two countries.

  19. Tööandja kulutused töötajatele, 2000 / Mare Kusma, Õie Palmre

    Index Scriptorium Estoniae

    Kusma, Mare

    2002-01-01

    Statistikaameti poolt esmakordselt korraldatud vaatluse "Tööandja kulutused töötajatele" metoodika ja tulemused. Summary: Labour costs, 2000. Tööjõukuludega seotud mõistete definitsioonid. Tabelid ja diagrammid

  20. TU-H-CAMPUS-IeP3-04: Evaluation of Changes in Quantitative Ultrasound Parameters During Prostate Radiotherapy

    International Nuclear Information System (INIS)

    Najafi, M; El Kaffas, A; Han, B; Cooper, D; Hancock, S; Hristov, D

    2016-01-01

    Purpose: Clarity Autoscan ultrasound monitoring system allows acquisition of raw radiofrequency (RF) ultrasound data prior and during radiotherapy. This enables the computation of 3D Quantitative Ultrasound (QUS) tissue parametric maps from. We aim to evaluate whether QUS parameters undergo changes with radiotherapy and thus potentially be used as early predictors and/or markers of treatment response in prostate cancer patients. Methods: In-vivo evaluation was performed under IRB protocol to allow data collection in prostate patients treated with VMAT whereby prostate was imaged through the acoustic window of the perineum. QUS spectroscopy analysis was carried out by computing a tissue power spectrum normalized to the power spectrum obtained from a quartz to remove system transfer function effects. A ROI was selected within the 3D image volume of the prostate. Because longitudinal registration was optimal, the same features could be used to select ROIs at roughly the same location in images acquired on different days. Parametric maps were generated within the rectangular ROIs with window sizes that were approximately 8 times the wavelength of the ultrasound. The mid-band fit (MBF), spectral slope (SS) and spectral intercept (SI) QUS parameters were computed for each window within the ROI and displayed as parametric maps. Quantitative parameters were obtained by averaging each of the spectral parameters over the whole ROI. Results: Data was acquired for over 21 treatment fractions. Preliminary results show changes in the parametric maps. MBF values decreased from −33.9 dB to −38.7 dB from pre-treatment to the last day of treatment. The spectral slope increased from −1.1 a.u. to −0.5 a.u., and spectral intercept decreased from −28.2 dB to −36.3 dB over the 21 treatment regimen. Conclusion: QUS parametric maps change over the course of treatment which warrants further investigation in their potential use for treatment planning and predicting treatment outcomes. Research was supported by Elekta.

  1. IE Information Notice No. 85-75: Improperly installed instrumentation, inadequate quality control and inadequate postmodification testing

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    On June 10, 1985, the licensee informed the NRC Resident Inspector that for approximately 5 days LaSalle Unit 2 had been without the capability of automatic actuation of emergency core cooling (ECCS) and that for approximately 3 days during this period the plant had been without secondary containment integrity. The major cause of this condition was improper installation (the variable and reference legs were reversed) of the two reactor vessel level actuation switches which control Division 1 automatic depressurization system (ADS), low pressure core spray (LPCS), and reactor core isolation cooling (RCIC). On July 20, 1985, the Trojan Nuclear Power Plant tripped from 100% power because of a turbine trip that was caused by the loss of the unit auxiliary transformer. All systems functioned normally except that low suction pressure caused one auxiliary feedwater pump to trip and then the other auxiliary feedwater pump to trip after restart of the first auxiliary feedwater pump. The cause of the trips of the auxiliary feedwater pumps can be traced back to improper postmodification adjustment and inadequate postmodification testing following retrofit of environmentally qualified controllers for the auxiliary feedwater system. The auxiliary feedwater pump trips on low suction pressure were caused by excessive combined flow from the two auxiliary feedwater pumps that draw from a single header from the condensate storage tank. The flow control valves were open farther than required after new environmentally qualified controllers had been installed during a recent refueling outage

  2. MO-FG-CAMPUS-IeP1-03: Establishment of Provincial Diagnostic Reference Levels in Pediatric Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tonkopi, E [Dalhousie University (Canada); Queen Elizabeth II Health Sciences Ctr (Canada); O’Brien, K [Dalhousie University (Canada); IWK Health Centre, Halifax, NS (Canada)

    2016-06-15

    Purpose: To establish provincial diagnostic reference levels (DRLs) in pediatric general radiography and computed tomography (CT) as a tool for the optimization of exposure parameters. Methods: Patient dose survey was conducted in the only pediatric hospital in the province of Nova Scotia. The DRLs were established as the 75th percentile of patient dose distributions in different age groups. For routine radiography projections the DRLs were determined in terms of entrance surface dose (ESD) calculated from the radiation output measurements and the tube current-exposure time product (mAs) recorded for each examination. Patient thickness was measured by the technologist during the examination. The CR and DR systems, employing respectively a fixed technique and phototiming, were evaluated separately; a two-tailed Student’s t-test was used to determine the significance of differences between the means of dose distributions. The CT studies included routine head, chest, abdomen/pelvis, and chest/abdomen/pelvis. The volume CT dose index (CTDIvol) and dose-length product (DLP) values were extracted retrospectively from PACS. The correction factors based on the effective diameter of the patient were applied to the CT dosimetry metrics based on the standard phantoms. Results: The provincial DRLs were established in the following age groups: newborn, 1, 5, 10, and 15 year olds. In general radiography the DR systems demonstrated slightly lower dose than the CR for all views, however the differences were not statistically significant (p > 0.05) for all examinations. In CT the provincial DRLs were lower than the published data, except for head DLPs in all age categories. This might be due to the small patient sample size in the survey. Future work will include additional CT data collection over an extended period of time. Conclusion: Provincial DRLs were established in the dedicated children’s hospital to provide guidance for the other facilities in examinations of pediatric patients.

  3. Grassy field margins as potential corridors for butterflies in agricultural landscapes: A simulation study

    Czech Academy of Sciences Publication Activity Database

    Delattre, T.; Pichancourt, J.- B.; Burel, F.; Kindlmann, Pavel

    2010-01-01

    Roč. 221, č. 2 (2010), s. 370-377 ISSN 0304-3800 R&D Projects: GA MŠk LC06073 Institutional research plan: CEZ:AV0Z60870520 Keywords : Connectivity * Grassland * Dispersal Subject RIV: EH - Ecology, Behaviour Impact factor: 1.769, year: 2010

  4. SU-G-IeP4-07: Feasibility of Low Dose 18FDG PET in Pediatric Oncology Patients

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, J; Binzel, K; Hall, NC; Natwa, M; Knopp, MI; Knopp, MV [The Ohio State University, Columbus, OH (United States)

    2016-06-15

    Purpose: To evaluate and demonstrate the feasibility of low dose FDG PET in pediatric oncology patients using virtual dose reduction as well as true patients PET/CT scans. Methods: Wholebody 18F-FDG PET/CT of 39 clinical pediatric patients (0.16±0.06MBq/kg) were scanned on a Gemini TF 64 system at 75±5 min post FDG injection using 3min/bed. Based on the 180s/bed listmode PET data, subsets of total counts in 120s, 90s, 60s, 30s and 15s per bed position were extracted for PET reconstruction to simulate lower dose PET at 2/3th, 1/2th, 1/3th, 1/6th and 1/12th dose levels. PET/CT scans of Jaszczak PET phantom with 6 hot hollow spheres varying with sizes and contrast ratios were performed (real PET versus simulated PET) to validate the methodology of virtual dose PET simulation. Region of interests (ROIs) were placed on lesions and normal anatomical tissues with quantitative and qualitative assessment performed. Significant lower FDG dose PET/CT of 5 research adolescents were scanned to validate the proposal and low dose PET feasibility. Results: Although all lesions are visible on the 1/12th dose PET, overall PET image quality appears to be influenced in a multi-factorial way. 30%–60% dose reduction from current standard of care FDG PET is recommended to maintain equivalent quality and PET quantification. An optimized BMI-based FDG administration is recommended (from 1.1±0.5 mCi for BMI < 18.5 to 4.8±1.5 mCi for BMI > 30). A linear lowest “Dose-BMI” relationship is given. SUVs from 1/12th to full dose PETs were identified as consistent (R2 = 1.08, 0.99, 1.01, 1.00 and 0.98). No significant variances of count density, SUV and SNR were found across certain dose ranges (p<0.01). Conclusion: Pediatric PET/CT can be performed using current time-of-flight systems at substantially lower PET doses (30–60%) than the standard of care PET/CT without compromising qualitative and quantitative image quality in clinical.

  5. IE Supplement No. 2 to Bulletin No. 79-01B: Environmental qualification of Class 1E equipment

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Enclosed are the generic questions and answers which resulted from NRC/Licensee meetings in NRC Regional Offices during the week of July 14, 1980 regarding environmental qualification of Class 1E equipment in use at power reactor facilities. These answers address specific questions asked during the meetings. Due to the generic nature of some of these questions, the staff is issuing them as a bulletin supplement. Some answers given in Supplement No. 1 to IEB-79-01B are superseded by these answers

  6. Thermal and physical property determination for IONSIV/256 IE-911 crystalline silicotitanate and Savannah River Site waste simulant solutions

    International Nuclear Information System (INIS)

    Canada, C.C.

    1999-01-01

    This document describes physical and thermophysical property determinations that were made in order to resolve questions associated with the decontamination of Savannah River Site waste streams using ion exchange on crystalline silicotitanate

  7. Do we really know Mup (i.e. the transition mass between Type Ia and core-collapse supernova progenitors)?

    International Nuclear Information System (INIS)

    Straniero, O; Piersanti, L; Cristallo, S

    2016-01-01

    M up is the minimum stellar mass that, after the core-helium burning, develops temperature and density conditions for the occurrence of a hydrostatic carbon burning. Stars whose mass is lower than this limit are the progenitors of C-O white dwarfs and, when belong to a close binary system, may give rise to explosive phenomena, such as novae or type Ia supernovae. Stars whose mass is only slightly larger than M up ignite C in a degenerate core and, in turn, experience a thermonuclear runaway. Their final fate may be a massive O-Ne WDs or, if the core mass approaches the Chandrasekhar limit, an e-capture SNe. More massive objects ignite C in non-degenerate conditions. These “massive “ stars are the progenitors of various kind of core-collapse supernovae (type IIp. IIL, IIN, Ib, Ic). It goes without saying that M up is a fundamental astrophysical parameter. From its knowledge depends our understanding of the SNe progenitors, of their rates, of the chemical evolution, of the WD luminosity functions and much more. A precise evaluation of M up relies on our knowledge of various input physics used in stellar modeling, such as the plasma neutrino rate, responsible of the cooling of the core, the equation of state of high density plasma, which affects the heating of the contracting core and its compressibility, and some key nuclear reaction rates, such as, in particular, the 12 C+ 12 C and the 12 C+α. In this paper we review the efforts made to determine this important parameter and we provide an up-to-date evaluation of the uncertainties due to the relevant nuclear physics inputs. (paper)

  8. The Effects of Cognitive Strategies i.e. Note-Making and Underlining on Iranian EFL Learners’ Reading Comprehension

    OpenAIRE

    Amir Mahdavi; Sadaf Azimi

    2012-01-01

    The purpose of this study was to investigate the effects of using cognitive strategies namely note- making and underlining, on Iranian EFL learners’ reading comprehension. In doing so, 60 female fourth year high school EFL learners were selected by means of the NELSON test (050A). They were then divided randomly into three groups, each group consisting of 20 homogeneous students: two experimental groups, and one control group. The experimental groups practiced note making (group A) and underl...

  9. The Effects of Cognitive Strategies i.e. Note-Making and Underlining on Iranian EFL Learners’ Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Amir Mahdavi

    2012-11-01

    Full Text Available The purpose of this study was to investigate the effects of using cognitive strategies namely note- making and underlining, on Iranian EFL learners’ reading comprehension. In doing so, 60 female fourth year high school EFL learners were selected by means of the NELSON test (050A. They were then divided randomly into three groups, each group consisting of 20 homogeneous students: two experimental groups, and one control group. The experimental groups practiced note making (group A and underlining reading strategies (group B on the same reading materials while the control group received the placebo. Then, all the subjects in the three groups took the same reading comprehension test. The results of a One-way Analysis of Variance (ANOVA and a post-hoc analysis of the Scheffe test showed that the learners who utilized note-making and underlining strategies outperformed the control group (p<.05. Furthermore, the experimental group who received note-making instruction revealed a higher efficiency than underlining group. As a result it can be concluded that note making and underlining have had positive effects on students’ rate of reading comprehensibility.

  10. Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates <i>E. coli survival in the inflamed gut

    DEFF Research Database (Denmark)

    Singh, Vishal; Yeoh, Beng San; Xiao, Xia

    2015-01-01

    During an inflammatory response in the gut, some commensal bacteria such as E. coli can thrive and contribute to disease. Here we demonstrate that enterobactin (Ent), a catecholate siderophore released by E. coli, is a potent inhibitor of myeloperoxidase (MPO), a bactericidal enzyme of the host. ...

  11. C4.TIO~ OF R4.U4.R ~ --IE UUF UURI~G WORL() W4.R II

    African Journals Online (AJOL)

    Throughout the history of large decisive cam- paigns and wars, and more so when opposing forces are clearly defined, appearing on a massive scale, conventional weapons and me- thods of warfare are produced in enormous quantities, to be used by every able-bodied person available; this because every war holds.

  12. MO-FG-CAMPUS-IeP2-04: Multiple Penalties with Different Orders for Structure Adaptive CBCT Reconstruction

    International Nuclear Information System (INIS)

    Shi, Q; Cheng, P; Tan, S; Tan, S; Wang, J

    2016-01-01

    Purpose: To combine total variation (TV) and Hessian penalty in a structure adaptive way for cone-beam CT (CBCT) reconstruction. Methods: TV is a widely used first order penalty with good ability in suppressing noise and preserving edges but leads to the staircase effect in regions with smooth intensity transition. The second order Hessian penalty can effectively suppress the staircase effect with extra cost of blurring object edges. To take the best of both penalties we proposed a novel method to combine both for CBCT reconstruction in a structure adaptive way. The proposed method adaptively determined the weight of each penalty according to the geometry of local regions. An specially-designed exponent term with image gradient involved was used to characterize the local geometry such that the weights for Hessian and TV were 1 and 0 respectively at uniform local regions and 0 and 1 at edge regions. For other local regions the weights varied from 0 to 1. The objective functional was minimized using the majorzationminimization approach. We evaluated the proposed method on a modified 3D shepp-logan and a CatPhan 600 phantom. The full-width-at-halfmaximum (FWHM) and contrast-to-noise (CNR) were calculated. Results: For 3D shepp-logan the reconstructed images using TV had an obvious staircase effect while those using the proposed method and Hessian preserved the smooth transition regions well. FWHMs of the proposed method TV and Hessian penalty were 1.75 1.61 and 3.16 respectively, indicating that both TV and the proposed method is able to preserve edges. For CatPhan 600 CNR values of the proposed method were similar to those of TV and Hessian. Conclusion: The proposed method retains favorable properties of TV like preserving edges and also has the ability in better preserving gradual transition structure as Hessian does. All methods performs similarly in suppressing noise. This work was supported in part by National Natural Science Foundation of China (NNSFC) under Grant Nos.60971112 and 61375018 grants from the Cancer Prevention and Research Institute of Texas (RP130109 and RP110562-P2) National Institute of Biomedical Imaging and Bioengineering (R01 EB020366) and a grant from the American Cancer Society (RSG-13-326-01-CCE).

  13. SU-G-IeP3-04: Effective Dose Measurements in Fast Kvp Switch Dual Energy Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Raudabaugh, J; Moore, B [Duke Medical Physics, Duke Radiation Dosimetry Laboratory (United States); Nguyen, G; Yoshizumi, T [Duke Radiology, Duke Radiation Dosimetry Laboratory (United States); Lowry, C; Nelson, R [Duke Radiology (United States)

    2016-06-15

    Purpose: The objective of this study was two-fold: (a) to test a new approach to approximating organ dose by using the effective energy of the combined 80kV/140kV beam in dual-energy (DE) computed tomography (CT), and (b) to derive the effective dose (ED) in the abdomen-pelvis protocol in DECT. Methods: A commercial dual energy CT scanner was employed using a fast-kV switch abdomen/pelvis protocol alternating between 80 kV and 140 kV. MOSFET detectors were used for organ dose measurements. First, an experimental validation of the dose equivalency between MOSFET and ion chamber (as a gold standard) was performed using a CTDI phantom. Second, the ED of DECT scans was measured using MOSFET detectors and an anthropomorphic phantom. For ED calculations, an abdomen/pelvis scan was used using ICRP 103 tissue weighting factors; ED was also computed using the AAPM Dose Length Product (DLP) method and compared to the MOSFET value. Results: The effective energy was determined as 42.9 kV under the combined beam from half-value layer (HVL) measurement. ED for the dual-energy scan was calculated as 16.49 ± 0.04 mSv by the MOSFET method and 14.62 mSv by the DLP method. Conclusion: Tissue dose in the center of the CTDI body phantom was 1.71 ± 0.01 cGy (ion chamber) and 1.71 ± 0.06 (MOSFET) respectively; this validated the use of effective energy method for organ dose estimation. ED from the abdomen-pelvis scan was calculated as 16.49 ± 0.04 mSv by MOSFET and 14.62 mSv by the DLP method; this suggests that the DLP method provides a reasonable approximation to the ED.

  14. Studiul structurii betonului ca mediu de protecţie a armăturilor împotriva coroziunii

    Directory of Open Access Journals (Sweden)

    Gheorghe Croitoru

    2011-09-01

    Full Text Available The paper presents a study of the processes of reinforcementcorrosion in concrete structures as a consequence of aggressive infiltration of water through cracks in the concrete. The rate of corrosion of reinforcement in concrete depends on the density and moisture content of concrete. Determine the effect of relative humidity (60 %, 80 %, 95 % on the rate of reinforcement corrosion, cracks in the zone, held in thermohydrostatic cells at 50 ° C, at high concentrations of oxygen and carbon dioxide than the environment. Duration of tests, depending on the degree of aggressiveness of the medium ranged from several days to severalmonths. During the tests, controlled temperature, relative humidity, gas concentration, humidity of the concrete and the environment. Whenhumidity variation from 35 to 60 %, the resistance of concrete increases slightly. With increasing relative humidity up to 80 % or more, the ohmic resistance decreases and the corrosion of reinforcement can have rapid development.

  15. SU-G-IeP3-10: Molecular Imaging with Clinical X-Ray Sources and Compton Cameras

    International Nuclear Information System (INIS)

    Vernekohl, D; Ahmad, M; Chinn, G; Xing, L

    2016-01-01

    Purpose: The application of Compton cameras (CC) is a novel approach translating XFCT to a practical modality realized with clinical CT systems without the restriction of pencil beams. The dual modality design offers additional information without extra patient dose. The purpose of this work is to investigate the feasibility and efficacy of using CCs for volumetric x-ray fluorescence (XF) imaging by Monte Carlo (MC) simulations and statistical image reconstruction. Methods: The feasibility of a CC for imaging x-ray fluorescence emitted from targeted lesions is examined by MC simulations. 3 mm diameter water spheres with various gold concentrations and detector distances are placed inside the lung of an adult human phantom (MIRD) and are irradiated with both fan and cone-beam geometries. A sandwich design CC composed of Silicon and CdTe is used to image the gold nanoparticle distribution. The detection system comprises four 16×26 cm"2 detector panels placed on the chest of a MIRD phantom. Constraints of energy-, spatial-resolution, clinical geometries and Doppler broadening are taken into account. Image reconstruction is performed with a list-mode MLEM algorithm with cone-projector on a GPU. Results: The comparison of reconstruction of cone- and fan-beam excitation shows that the spatial resolution is improved by 23% for fan-beams with significantly decreased processing time. Cone-beam excitation increases scatter content disturbing quantification of lesions near the body surface. Spatial resolution and detectability limit in the center of the lung is 8.7 mm and 20 fM for 50 nm diameter gold nanoparticles at 20 mGy. Conclusion: The implementation of XFCT with a CC is a feasible method for molecular imaging with high atomic number probes. Given constrains of detector resolutions, Doppler broadening, and limited exposure dose, spatial resolutions comparable with PET and molecular sensitivities in the fM range are realizable with current detector technology.

  16. Reconceptualizarea funcţiei procurorului de supraveghere a activităţii speciale de investigaţie

    Directory of Open Access Journals (Sweden)

    Obadă Dumitru

    2018-01-01

    Full Text Available This paper is an endeavor to analyze Moldova’s legal framework aimed at regulating Special investigative activity in terms ofsubjects and their functional competencies, invested by a legislator with duties of supervisingSpecial investigative measures. It is also an attempt to reveal the normative inconsistencies specified in the regulatory content of the Criminal Procedural Law, including a verifiable analysis of the legal norms stipulated in the Code of Criminal Procedure, as well as other regulations related to this specific area of state activity specified in the related legislation. Moreover, the author sought to highlight the adverse legal effects that may be generated by the misinterpretation and misapplication of the legal norms related to Special investigative activity. While carrying out this study, we have taken into account the practice of law enforcement by state bodies in conducting criminal investigations, as well as the attempt to clarify and define the concept of ,,supervising special investigative activity”.

  17. SU-G-IeP4-07: Feasibility of Low Dose 18FDG PET in Pediatric Oncology Patients

    International Nuclear Information System (INIS)

    Zhang, J; Binzel, K; Hall, NC; Natwa, M; Knopp, MI; Knopp, MV

    2016-01-01

    Purpose: To evaluate and demonstrate the feasibility of low dose FDG PET in pediatric oncology patients using virtual dose reduction as well as true patients PET/CT scans. Methods: Wholebody 18F-FDG PET/CT of 39 clinical pediatric patients (0.16±0.06MBq/kg) were scanned on a Gemini TF 64 system at 75±5 min post FDG injection using 3min/bed. Based on the 180s/bed listmode PET data, subsets of total counts in 120s, 90s, 60s, 30s and 15s per bed position were extracted for PET reconstruction to simulate lower dose PET at 2/3th, 1/2th, 1/3th, 1/6th and 1/12th dose levels. PET/CT scans of Jaszczak PET phantom with 6 hot hollow spheres varying with sizes and contrast ratios were performed (real PET versus simulated PET) to validate the methodology of virtual dose PET simulation. Region of interests (ROIs) were placed on lesions and normal anatomical tissues with quantitative and qualitative assessment performed. Significant lower FDG dose PET/CT of 5 research adolescents were scanned to validate the proposal and low dose PET feasibility. Results: Although all lesions are visible on the 1/12th dose PET, overall PET image quality appears to be influenced in a multi-factorial way. 30%–60% dose reduction from current standard of care FDG PET is recommended to maintain equivalent quality and PET quantification. An optimized BMI-based FDG administration is recommended (from 1.1±0.5 mCi for BMI 30). A linear lowest “Dose-BMI” relationship is given. SUVs from 1/12th to full dose PETs were identified as consistent (R2 = 1.08, 0.99, 1.01, 1.00 and 0.98). No significant variances of count density, SUV and SNR were found across certain dose ranges (p<0.01). Conclusion: Pediatric PET/CT can be performed using current time-of-flight systems at substantially lower PET doses (30–60%) than the standard of care PET/CT without compromising qualitative and quantitative image quality in clinical.

  18. Managing the IE (Industrial Engineering Mindset: A quantitative investigation of Toyota’s practical thinking shared among employees

    Directory of Open Access Journals (Sweden)

    Phillip Marksberry

    2011-12-01

    Full Text Available Purpose: The goal of this work was to investigate the managerial practices of today to understand if Toyota is sheltering themselves from these newer practices or embracing them like most believe.Design/methodology/approach: This work utilizes a new form of data mining named Latent Semantic Analysis (LSA to analyze an organizations ideal management practices.Findings: This work shows quantitatively that TPS favors earlier versions of industrial engineering compared to the optimization techniques available today.Originality/value: The use of data mining to analyze organizational management practices.

  19. D IE H EID ELB ER G SE KATEG ISM USAS KERKLIK E SIM BO O L ...

    African Journals Online (AJOL)

    Test

    maal en die tweede oor die Uitverkiesing. W at die Heidelbergse Kategismus aanbetref, dit is eers geleidelik n dertigtal jare na die ontstaan van die Nederlandse Geloofsbelydenis as kerklike simboliese geskrif beskou. Dit bevat nie leerstellings wat. 3) In Holland het die Chr. Gereformeerde Kerk meermale 'n handboek ...

  20. SU-G-IeP3-10: Molecular Imaging with Clinical X-Ray Sources and Compton Cameras

    Energy Technology Data Exchange (ETDEWEB)

    Vernekohl, D; Ahmad, M; Chinn, G; Xing, L [Stanford University, Stanford, CA (United States)

    2016-06-15

    Purpose: The application of Compton cameras (CC) is a novel approach translating XFCT to a practical modality realized with clinical CT systems without the restriction of pencil beams. The dual modality design offers additional information without extra patient dose. The purpose of this work is to investigate the feasibility and efficacy of using CCs for volumetric x-ray fluorescence (XF) imaging by Monte Carlo (MC) simulations and statistical image reconstruction. Methods: The feasibility of a CC for imaging x-ray fluorescence emitted from targeted lesions is examined by MC simulations. 3 mm diameter water spheres with various gold concentrations and detector distances are placed inside the lung of an adult human phantom (MIRD) and are irradiated with both fan and cone-beam geometries. A sandwich design CC composed of Silicon and CdTe is used to image the gold nanoparticle distribution. The detection system comprises four 16×26 cm{sup 2} detector panels placed on the chest of a MIRD phantom. Constraints of energy-, spatial-resolution, clinical geometries and Doppler broadening are taken into account. Image reconstruction is performed with a list-mode MLEM algorithm with cone-projector on a GPU. Results: The comparison of reconstruction of cone- and fan-beam excitation shows that the spatial resolution is improved by 23% for fan-beams with significantly decreased processing time. Cone-beam excitation increases scatter content disturbing quantification of lesions near the body surface. Spatial resolution and detectability limit in the center of the lung is 8.7 mm and 20 fM for 50 nm diameter gold nanoparticles at 20 mGy. Conclusion: The implementation of XFCT with a CC is a feasible method for molecular imaging with high atomic number probes. Given constrains of detector resolutions, Doppler broadening, and limited exposure dose, spatial resolutions comparable with PET and molecular sensitivities in the fM range are realizable with current detector technology.

  1. SU-G-IeP2-13: Toward Heavy Ion Computed Tomography with Carbon Ions: A Monte Carlo Study

    Energy Technology Data Exchange (ETDEWEB)

    Shrestha, D; Qin, N; Zhang, Y; Jia, X; Wang, J [UT Southwestern Medical Center, Dallas, TX (United States)

    2016-06-15

    Purpose: In the present Monte Carlo study, we investigated the use of Carbon ions for computed tomography (CT) with a relatively low imaging dose. This will enable us to avoid any conversion of X-ray CT numbers to the relative stopping power (or relative electron density) values and the associated uncertainties in Carbon dose calculation. Methods: In the first stage, we studied the propagation of Carbon nuclei through a water phantom using the Geant4 specially to understand their lateral displacement inside the phantom. In the second stage, we used our GPU-based Monte Carlo code, which has been cross validated against Geant4, to create the 2D map of the water equivalent path length (WEPL) inside a human head size phantom by acquiring 240 projections each 1.5° apart. Subsequently the 3D relative electron density map of the phantom was reconstructed from the 2D WEPL map using the Algebraic Reconstruction Technique (ART) coupled with total variation (TV) minimization Results: A high quality image of the relative electron density inside the phantom was reconstructed by ARTTV. The mean relative error between the reconstructed image for low contrast object (PMMA) was about 1.74%. The delivered dose per scan at the center of the phantom was about 0.1 Gy. Conclusion: We have been able to obtain a 3D map of the electron density using a human head size phantom while keeping the delivered dose to relatively low value. Using the GPU capabilities of our simulation engine, we believe that a real time CT with Carbon ions could be a reality in future.

  2. The Hungarian Counter Improvised Explosive Device (C-IED) Strategy: Considering the Use of Military Working Dogs

    Science.gov (United States)

    2014-12-12

    language forming efforts. Special thanks for Dr. Rhoda Risner, my small group leader, for the guidance and support. Finally, thanks to my student...in the “no man’s land” but also in the trenches. The unburied dead bodies and the countless injures mixed with the muddy environment and provided...There are many war stories about canine heroes that carried messages for long periods with several injuries. The other effort was the fight against the

  3. Test and Research Reactor Fuel Element Fabrication Plant. IE inspection report No. 75-09 and reply

    International Nuclear Information System (INIS)

    1976-01-01

    Copies of the following documents relating to U. S. Nuclear, Inc., Docket No. 70-1319 are presented: Letter to U. S. Nuclear, Inc. from J. T. Sutherland dated February 3, 1976; Letter to N. C. Moseley from U. S. Nuclear, Inc. dated January 28, 1976; Letter to N. C. Moseley from U. S. Nuclear, Inc. dated January 19, 1976; Letter to U. S. Nuclear, Inc. from N. C. Moseley dated December 22, 1975; and Region II Inspection Report No. 70-1319/75-9

  4. Land reform in Russia in 1990-2000-ies, or how land reform was "reformed" during the departmental reorganization

    Directory of Open Access Journals (Sweden)

    Barsukova Svetlana, Yu.

    2015-06-01

    Full Text Available The paper provides an overview of the land reform in Russia's recent history. Analysis of land reform, which started in 1990, shows what actions and what logic led the land sector in the state in which it was at the finish line of the quarter-century reform marathon. The reform process was not linear, it highlighted the steps differing objectives and strategies to achieve them. Land reform is presented as a struggle of different political forces, which were reflected in the redistribution of functions between agencies in lobbying for appointment to senior positions promoted various commands. The authors conclude about the gradual displacement of state regulation of land relations, the deliberate destruction of the land management as a basis for the development of land resources.

  5. Older Adults Accessing HIV Care and Treatment and Adherence in the IeDEA Central Africa Cohort

    Directory of Open Access Journals (Sweden)

    Jamie Newman

    2012-01-01

    Full Text Available Background. Very little is known about older adults accessing HIV care in sub-Saharan Africa. Materials and Methods. Data were obtained from 18,839 HIV-positive adults at 10 treatment programs in Burundi, Cameroon, and the Democratic Republic of Congo. We compared characteristics of those aged 50+ with those aged 18–49 using chi-square tests. Logistic regression was used to determine if age was associated with medication adherence. Results. 15% of adults were 50+ years. Those aged 50+ were more evenly distributed between women and men (56% versus 44% as compared to those aged 18–49 (71% versus 29% and were more likely to be hypertensive (8% versus 3% (P<0.05. Those aged 50+ were more likely to be adherent to their medications than those aged 18–49 (P<0.001. Adults who were not heavy drinkers reported better adherence as compared to those who reported drinking three or more alcoholic beverages per day (P<0.001. Conclusions. Older adults differed from their younger counterparts in terms of medication adherence, sociodemographic, behavioral, and clinical characteristics.

  6. ied ja sõlmed tõid Katrina Kaubile võidu / Monika Puutsa

    Index Scriptorium Estoniae

    Puutsa, Monika

    2007-01-01

    Supernoova moevõistluse tulemustest. Noorte disainerite auhind Katrina Kaubile oli 20 000 krooni ja Supernoova hõbedane pross, vanemas kategoorias Liisi Eesmaale 50 000 krooni. Žürii koosseis. Katrina Kaubi kommentaarid

  7. SU-G-IeP3-13: Real-Time Patient and Staff Dose Monitoring in Fluoroscopy Guided Interventions

    International Nuclear Information System (INIS)

    Vergoossen, L; Sailer, A; Paulis, L; Wildberger, J; Jeukens, C

    2016-01-01

    Purpose: Interventional radiology procedures involve the use of X-rays, which can pose a large radiation burden on both patients and staff. Although some reports on radiation dose are available, most studies focus on limited types of procedures and only report patient dose. In our cathlabs a dedicated real-time patient and staff monitoring system was installed in November 2015. The aim of this study was to investigate the patient and staff dose exposure for different types of interventions. Methods: Radiologists involved in fluoroscopy guided interventional radiology procedures wore personal dose meters (PDM, DoseAware, Philips) on their lead-apron that measured the personal dose equivalent Hp(10), a measure for the effective dose (E). Furthermore, reference PDMs were installed in the C-arms of the fluoroscopy system (Allura XPer, Philips). Patient dose-area-product (DAP) and PDM doses were retrieved from the monitoring system (DoseWise, Philips) for each procedure. A total of 399 procedures performed between November 2015 and February 2016 were analyzed with respect to the type of intervention. Interventions were grouped by anatomy and radiologist position. Results: The mean DAP for the different types of interventions ranged from 2.86±2.96 Gycm"2 (percutaneous gastrostomy) to 147±178 Gycm"2 (aortic repair procedures). The radiologist dose (E) ranged from 5.39±7.38 µSv (cerebral interventions) to 84.7±106 µSv (abdominal interventions) and strongly correlated with DAP (R"2=0.83). The E normalized to DAP showed that the relative radiologist dose was higher for interventions in larger body parts (e.g. abdomen) compared to smaller body parts (e.g. head). Conclusion: Using a real-time dose monitoring system we were able to assess the staff and patient dose revealing that the relative staff dose strongly depended on the type of procedure and patient anatomy. This could be explained by the position of the radiologist with respect to the patient and X-ray tube. To facilitate this study L Vergoossen received a scholarship from Philips Medical Systems.

  8. Self(ie-esteem? – A manifestation of adolescent self-creating endeavours in the virtual space of Facebook

    Directory of Open Access Journals (Sweden)

    Lili Fejes-Vékássy

    2017-09-01

    Full Text Available In the centre of our interest stand the manifestations of adolescent self-creating endeavours in the virtual space of the social media portal called Facebook. Frequent self-photography (selfie making, as a pronounced cultural feature of contemporary youth, and regular activity on Facebook handled as tightly connected factors; we propose that youngsters, bearing these attributes, have a different self-esteem than those adolescents who rarely or never take any photographs of themselves. In the first, quantitative part of our research the participants (N=80 filled in the Rosenberg Self-Esteem Scale and a questionnaire containing questions in connection with Facebook-usage (compiled by us. In the qualitative part of the research the participants took part in a half-structured interview, containing questions in connection with selfie­-making (also compiled by us. Our hypothesis was not proven by the statistical analysis, no connection could be testified between frequent selfie-making and low self-esteem.

  9. Ie - riss: una herramienta computacional para la estimación de pérdidas por sismo en edificaciones

    OpenAIRE

    SIERRA ÁLVAREZ, CÉSAR AUGUSTO; JARAMILLO FERNÁNDEZ, JUAN DIEGO

    2012-01-01

    Una formulación probabilista para estimar tasas de excedencia de pérdidas por terremoto es presentada. Luego de exponer la utilidad de este tipo de modelos, se presenta la formulación matemática de un modelo Poissoniano que considera la incertidumbre de variables tales como: magnitud en la fuente, intensidad del movimiento en el basamento rocoso, intensidad del movimiento a nivel de la superficie del suelo y daño en las edificaciones. Los resultados se sintetizan en las tasas de excedencia an...

  10. SU-G-IeP4-13: PET Image Noise Variability and Its Consequences for Quantifying Tumor Hypoxia

    Energy Technology Data Exchange (ETDEWEB)

    Kueng, R [Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern (Switzerland); Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Manser, P; Fix, M K [Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern (Switzerland); Driscoll, B; Keller, H [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Stampanoni, M F M [Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology (ETH) (Switzerland)

    2016-06-15

    Purpose: The values in a PET image which represent activity concentrations of a radioactive tracer are influenced by a large number of parameters including patient conditions as well as image acquisition and reconstruction. This work investigates noise characteristics in PET images for various image acquisition and image reconstruction parameters. Methods: Different phantoms with homogeneous activity distributions were scanned using several acquisition parameters and reconstructed with numerous sets of reconstruction parameters. Images from six PET scanners from different vendors were analyzed and compared with respect to quantitative noise characteristics. Local noise metrics, which give rise to a threshold value defining the metric of hypoxic fraction, as well as global noise measures in terms of noise power spectra (NPS) were computed. In addition to variability due to different reconstruction parameters, spatial variability of activity distribution and its noise metrics were investigated. Patient data from clinical trials were mapped onto phantom scans to explore the impact of the scanner’s intrinsic noise variability on quantitative clinical analysis. Results: Local noise metrics showed substantial variability up to an order of magnitude for different reconstruction parameters. Investigations of corresponding NPS revealed reconstruction dependent structural noise characteristics. For the acquisition parameters, noise metrics were guided by Poisson statistics. Large spatial non-uniformity of the noise was observed in both axial and radial direction of a PET image. In addition, activity concentrations in PET images of homogeneous phantom scans showed intriguing spatial fluctuations for most scanners. The clinical metric of the hypoxic fraction was shown to be considerably influenced by the PET scanner’s spatial noise characteristics. Conclusion: We showed that a hypoxic fraction metric based on noise characteristics requires careful consideration of the various dependencies in order to justify its quantitative validity. This work may result in recommendations for harmonizing QA of PET imaging for multi-institutional clinical trials.

  11. SU-G-IeP4-06: Feasibility of External Beam Treatment Field Verification Using Cherenkov Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Black, P; Na, Y; Wuu, C [Columbia University, New York, NY (United States)

    2016-06-15

    Purpose: Cherenkov light emission has been shown to correlate with ionizing radiation (IR) dose delivery in solid tissue. In order to properly correlate Cherenkov light images with real time dose delivery in a patient, we must account for geometric and intensity distortions arising from observation angle, as well as the effect of monitor units (MU) and field size on Cherenkov light emission. To test the feasibility of treatment field verification, we first focused on Cherenkov light emission efficiency based on MU and known field size (FS). Methods: Cherenkov light emission was captured using a PI-MAX4 intensified charge coupled device(ICCD) system (Princeton Instruments), positioned at a fixed angle of 40° relative to the beam central axis. A Varian TrueBeam linear accelerator (linac) was operated at 6MV and 600MU/min to deliver an Anterior-Posterior beam to a 5cm thick block phantom positioned at 100cm Source-to-Surface-Distance(SSD). FS of 10×10, 5×5, and 2×2cm{sup 2} were used. Before beam delivery projected light field images were acquired, ensuring that geometric distortions were consistent when measuring Cherenkov field discrepancies. Cherenkov image acquisition was triggered by linac target current. 500 frames were acquired for each FS. Composite images were created through summation of frames and background subtraction. MU per image was calculated based on linac pulse delay of 2.8ms. Cherenkov and projected light FS were evaluated using ImageJ software. Results: Mean Cherenkov FS discrepancies compared to light field were <0.5cm for 5.6, 2.8, and 8.6 MU for 10×10, 5×5, and 2×2cm{sup 2} FS, respectably. Discrepancies were reduced with increasing field size and MU. We predict a minimum of 100 frames is needed for reliable confirmation of delivered FS. Conclusion: Current discrepancies in Cherenkov field sizes are within a usable range to confirm treatment delivery in standard and respiratory gated clinical scenarios at MU levels appropriate to standard MLC position segments.

  12. Differential expression of small RNAs under chemical stress and fed-batch fermentation in <i>E. coli

    DEFF Research Database (Denmark)

    Rau, Martin Holm; Nielsen, Alex Toftgaard; Long, Katherine

    2015-01-01

    Bacterial small RNAs (sRNAs) are recognized as posttranscriptional regulators involved in the control of bacterial lifestyle and adaptation to stressful conditions. Although chemical stress due to the toxicity of precursor and product compounds is frequently encountered in microbial bioprocessing...

  13. Self(ie)-esteem? – A manifestation of adolescent self-creating endeavours in the virtual space of Facebook

    OpenAIRE

    Lili Fejes-Vékássy

    2017-01-01

    In the centre of our interest stand the manifestations of adolescent self-creating endeavours in the virtual space of the social media portal called Facebook. Frequent self-photography (selfie) making, as a pronounced cultural feature of contemporary youth, and regular activity on Facebook handled as tightly connected factors; we propose that youngsters, bearing these attributes, have a different self-esteem than those adolescents who rarely or never take any photographs of themselves. In the...

  14. El Direccionamiento Estratégico de las IES en el Ecuador Apalancado en las TIC. Caso: Universidad Estatal De Milagro

    Directory of Open Access Journals (Sweden)

    Vinueza-Martínez, Jorge

    2013-06-01

    Full Text Available Today the Higher Education Institutions (HEIs from Ecuador and other Latin American countries lack, within the administration, a basic methodology that promotes the development, measurement, control and monitoring standardized, short, medium and long term , Institutional Plans. This creates the need to design and implement a Strategic Management Model and Operational Miracle State University, UNEMI, as part of the Integrated Planning as standardized assessment and learning is a process that must reflect intrinsic outcome quality, based on measurable objectives and initiatives, and obtained by measurement techniques to quantify the achievement of the objectives. It also reveals the lack of definition of ICT-based processes and information systems that optimize the monitoring and control of programs and projects. The evaluation and monitoring are fundamental strategic direction to measure the achievement of results, without planning support tools, such as: POA [Annual Operating Plan], PAT [Annual Technology Plan], PAC [Annual Procurement Plan], PAI [Annual Investment Plan], it is difficult to accurately quantify the level of performance of this institution.

  15. Negocierea contractului colectiv de muncă la nivel de instituție publică - Proces și rezultat

    Directory of Open Access Journals (Sweden)

    Gabriela HENER

    2006-06-01

    Full Text Available The Collective Labor Contract is the result of an agreement between the employees and their employer. However, the most relevant aspect is the way and steps that lead to this result, namely the entire process of negotiation. Upon this process and the way negotiators choose to use their abilities, personal qualities, tactics, tricks and strategies in order to reach their goals, will depend this agreement. So, to be able to understand the final agreement, the whole process must be taken in consideration, but also the legal and economical conditions, especially when dealing with public institutions. It is also recommended that people should be informed about the entire process, not only about its results.

  16. MO-FG-CAMPUS-IeP2-01: Characterization of Beam Shaping Filters and Photon Spectra From HVL Profiles in CT

    Energy Technology Data Exchange (ETDEWEB)

    Bujila, R [Karolinska University Hospital, Stockholm (Sweden); Royal Institute of Technology, Stockholm (Sweden); Kull, L [Sunderby Hospital, Lulea (Sweden); Nowik, P; Poludniowski, G [Karolinska University Hospital, Stockholm (Sweden); Andersson, J [Umea University, Umea (Sweden)

    2016-06-15

    Purpose: Advanced dosimetry in CT (e.g. the Monte Carlo method) requires an accurate characterization of the shaped filter and radiation quality used during a scan. The purpose of this work was to develop a method where half value layer (HVL) profiles along shaped filters could be made. From the HVL profiles the beam shaping properties and effective photon spectrum for a particular scan can be inferred. Methods: A measurement rig was developed to allow determinations of the HVL under a scatter-free narrow-beam geometry and constant focal spot to ionization chamber distance for different fan angles. For each fan angle the HVL is obtained by fitting the transmission of radiation through different thicknesses of an Al absorber (type 1100) using an appropriate model. The effective Al thickness of shaped filters and effective photon spectra are estimated using a model of photon emission from a Tungsten anode. This method is used to obtain the effective photon spectra and effective Al thickness of shaped filters for a CT scanner recently introduced to the market. Results: This study resulted in a set of effective photon spectra (central ray) for each kVp along with effective Al thicknesses of the different shaped filters. The effective photon spectra and effective Al thicknesses of shaped filters were used to obtain numerically approximated HVL profiles and compared to measured HVL profiles (mean absolute percentage error = 0.02). The central axis HVL found in the vendor’s technical documentation were compared to approximated HVL values (mean absolute percentage error = 0.03). Conclusion: This work has resulted in a unique method of measuring HVL profiles along shaped filters in CT. Further the effective photon spectra and the effective Al thicknesses of shaped filters that were obtained can be incorporated into Monte Carlo simulations.

  17. Drumul politic pentru nominalizarea lui Klaus Iohannis la Președinție (The Political road to presidential candidacy nomination of Klaus Iohannis

    Directory of Open Access Journals (Sweden)

    Florin GRECU

    2015-09-01

    Full Text Available The article analyses the process which led to the nominalization of Klaus Iohannis as candidate in the presidential election campaign representing the Christian Liberal Alliance. The adhesion of the National Liberal Party to the European popular party, the retreat of PNL’s president Crin Antonescu from the presidential race and the ascent of the mayor of Sibiu on the political stage, represent the analytical aim of this study, trough statements and media articles. The causes and the stakes of the change of the political affiliation of the Liberal National Party and the reasons of the adhesion to PPE which led locally to the fusion with the Liberal Democrat Party, will be shown by analyzing the statements of the political actors involved in the negotiation and in the political compromise that named Iohannis as the candidate of the right wing, who was already convinced since fall 2014 of winning the elections. The political actors, the PPE members trough their statements and actions, they sustained their candidate during the campaign and through congratulation letters after winning the elections.

  18. SU-G-IeP3-08: Image Reconstruction for Scanning Imaging System Based On Shape-Modulated Point Spreading Function

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruixing; Yang, LV [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha, Hunan (China); Xu, Kele [College of Electronical Science and Engineering, National University of Defense Technology, Changsha, Hunan (China); Zhu, Li [Institute of Electrostatic and Electromagnetic Protection, Mechanical Engineering College, Shijiazhuang, Hebei (China)

    2016-06-15

    Purpose: Deconvolution is a widely used tool in the field of image reconstruction algorithm when the linear imaging system has been blurred by the imperfect system transfer function. However, due to the nature of Gaussian-liked distribution for point spread function (PSF), the components with coherent high frequency in the image are hard to restored in most of the previous scanning imaging system, even the relatively accurate PSF is acquired. We propose a novel method for deconvolution of images which are obtained by using shape-modulated PSF. Methods: We use two different types of PSF - Gaussian shape and donut shape - to convolute the original image in order to simulate the process of scanning imaging. By employing deconvolution of the two images with corresponding given priors, the image quality of the deblurred images are compared. Then we find the critical size of the donut shape compared with the Gaussian shape which has similar deconvolution results. Through calculation of tightened focusing process using radially polarized beam, such size of donut is achievable under same conditions. Results: The effects of different relative size of donut and Gaussian shapes are investigated. When the full width at half maximum (FWHM) ratio of donut and Gaussian shape is set about 1.83, similar resolution results are obtained through our deconvolution method. Decreasing the size of donut will favor the deconvolution method. A mask with both amplitude and phase modulation is used to create a donut-shaped PSF compared with the non-modulated Gaussian PSF. Donut with size smaller than our critical value is obtained. Conclusion: The utility of donutshaped PSF are proved useful and achievable in the imaging and deconvolution processing, which is expected to have potential practical applications in high resolution imaging for biological samples.

  19. Vínculos com a Carreira e Produção Acadêmica: Comparando Docentes de IES Públicas e Privadas

    Directory of Open Access Journals (Sweden)

    Diva Ester Okazaki Rowe

    2010-11-01

    Full Text Available Research into the relationship between work and career involves two constructs - commitment and entrenchment, whose influence on performance have yet to be fully understood. The main goal of this study is to analyze the influences of the dimensions of links with the academic career of teaching in the contexts of public and private higher education in Brazil. This research is extensive in nature and cross-sectional. For data collection, a questionnaire which had previously been validated for the Brazilian context was applied containing a set of scales to measure career commitment and entrenchment. The links with the careers were measured by thescales proposed and validated by Carson and Bedeian (1994 and Carson, Carson and Bedeian (1995, while the performance of teachers includes points taken from their Curriculum Vitae of the Lattes Database, in accordance with the practice used by Oliveira (1998. We surveyed 635 teachers, whose data were submitted to descriptive analysis, factor analysis and structural equation modeling. The best fit model reveals that the more time and money teachers invest in their careers, the greater their academic performance will be. We also found differences in the influences of the two links to career in academic performance between private and public higher education establishments.

  20. TU-H-CAMPUS-IeP1-05: A Framework for the Analytic Calculation of Patient-Specific Dose Distribution Due to CBCT Scan for IGRT

    Energy Technology Data Exchange (ETDEWEB)

    Youn, H; Jeon, H; Nam, J; Lee, J; Lee, J [Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do (Korea, Republic of); Kim, J; Kim, H [Pusan National University, Busan (Korea, Republic of); Cho, M; Yun, S [Samsung electronics Co., Suwon, Gyeonggi-do (Korea, Republic of); Park, D; Kim, W; Ki, Y; Kim, D [Pusan National University Hospital, Busan (Korea, Republic of)

    2016-06-15

    Purpose: To investigate the feasibility of an analytic framework to estimate patients’ absorbed dose distribution owing to daily cone-beam CT scan for image-guided radiation treatment. Methods: To compute total absorbed dose distribution, we separated the framework into primary and scattered dose calculations. Using the source parameters such as voltage, current, and bowtie filtration, for the primary dose calculation, we simulated the forward projection from the source to each voxel of an imaging object including some inhomogeneous inserts. Then we calculated the primary absorbed dose at each voxel based on the absorption probability deduced from the HU values and Beer’s law. In sequence, all voxels constructing the phantom were regarded as secondary sources to radiate scattered photons for scattered dose calculation. Details of forward projection were identical to that of the previous step. The secondary source intensities were given by using scatter-to- primary ratios provided by NIST. In addition, we compared the analytically calculated dose distribution with their Monte Carlo simulation results. Results: The suggested framework for absorbed dose estimation successfully provided the primary and secondary dose distributions of the phantom. Moreover, our analytic dose calculations and Monte Carlo calculations were well agreed each other even near the inhomogeneous inserts. Conclusion: This work indicated that our framework can be an effective monitor to estimate a patient’s exposure owing to cone-beam CT scan for image-guided radiation treatment. Therefore, we expected that the patient’s over-exposure during IGRT might be prevented by our framework.

  1. MO-FG-CAMPUS-IeP1-02: Dose Reduction in Contrast-Enhanced Digital Mammography Using a Photon-Counting Detector

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Kang, S; Eom, J [Konyang University, Daejeon (Korea, Republic of)

    2016-06-15

    Purpose: Photon-counting detectors (PCDs) allow multi-energy X-ray imaging without additional exposures and spectral overlap. This capability results in the improvement of accuracy of material decomposition for dual-energy X-ray imaging and the reduction of radiation dose. In this study, the PCD-based contrast-enhanced dual-energy mammography (CEDM) was compared with the conventional CDEM in terms of radiation dose, image quality and accuracy of material decomposition. Methods: A dual-energy model was designed by using Beer-Lambert’s law and rational inverse fitting function for decomposing materials from a polychromatic X-ray source. A cadmium zinc telluride (CZT)-based PCD, which has five energy thresholds, and iodine solutions included in a 3D half-cylindrical phantom, which composed of 50% glandular and 50% adipose tissues, were simulated by using a Monte Carlo simulation tool. The low- and high-energy images were obtained in accordance with the clinical exposure conditions for the conventional CDEM. Energy bins of 20–33 and 34–50 keV were defined from X-ray energy spectra simulated at 50 kVp with different dose levels for implementing the PCD-based CDEM. The dual-energy mammographic techniques were compared by means of absorbed dose, noise property and normalized root-mean-square error (NRMSE). Results: Comparing to the conventional CEDM, the iodine solutions were clearly decomposed for the PCD-based CEDM. Although the radiation dose for the PCD-based CDEM was lower than that for the conventional CEDM, the PCD-based CDEM improved the noise property and accuracy of decomposition images. Conclusion: This study demonstrates that the PCD-based CDEM allows the quantitative material decomposition, and reduces radiation dose in comparison with the conventional CDEM. Therefore, the PCD-based CDEM is able to provide useful information for detecting breast tumor and enhancing diagnostic accuracy in mammography.

  2. Estándares internacionales de educación (IES en contabilidad y aseguramiento: nuevos retos de la profesión contable

    Directory of Open Access Journals (Sweden)

    Carlos Castillo Muñoz

    2014-07-01

    Full Text Available La profesión contable no es ajena a los efectos de la globalización, y en sintonía con ésta, en Colombia la ley 1314 de 2009 definió la inserción del conglomerado empresarial al modelo contable internacional, más conocido como NIC-NIIF, por ello en la actualidad se desarrollan procesos de convergencia. Sin embargo, es poco lo que se ha avanzado en la determinación y acuerdos sobre la educación en contabilidad internacional y aseguramiento de futuros Contadores Públicos, y sobre la actualización de aquéllos en ejercicio. De lo anterior, se desprende la necesidad de reflexionar sobre los aspectos vinculados a la educación superior y dar respuesta a la pregunta ¿Qué aspectos se deben tener en cuenta para la educación y formación frente al proceso de convergencia hacia estándares internacionales de información financiera y aseguramiento? Agregado a lo anterior, el propósito central es revisar las directrices de la Federación Internacional de Contadores - IFAC (Por su sigla en inglés para la educación de los contadores profesionales. La metodología utilizada es descriptiva, acompañada de una revisión bibliográfica reflexiva en torno a la globalización y los estándares internacionales de educación emitidos por la IFAC. El artículo deja entrever los propósitos de tiempo atrás sobre la formación de contadores, fundamentados en el modelo global y los principales elementos de discusión al interior de las Instituciones de Educación Superior para planificar a futuro la oferta académica a nivel de pregrado y posgrado.

  3. SU-G-IeP2-05: Effect of Localizer Type and Patient Off-Centering On CT Radiation Dose with Use of Automatic Tube Current Modulation

    Energy Technology Data Exchange (ETDEWEB)

    Ruan, C; Sodickson, A; Hamberg, L [Brigham and Women’s Hospital, Boston, MA (United States)

    2016-06-15

    Purpose: Apparent patient size in CT localizers varies with localizer type and patient positioning, resulting in variation in effective mAs as guided by Tube Current Modulation (TCM). Our aim was to investigate the effects of vertical off-centering on CTDI-vol when using different localizer types and TCM strengths. Methods: A CTDI body phantom was scanned using an abdominal protocol with three TCM strengths (Siemens Definition AS40, CAREDose4D; very weak, average, very strong). Data was acquired at 11 table height positions; with phantom center at isocenter and at 10 other positions between 142mm below and 53mm above. At each position, scans were acquired using 5 different localizer types: PA, AP, Lateral, PA+Lateral, and Lateral+PA. CTDI-vol was recorded for the 165 combinations of table height, localizer type, and TCM strength, and magnification factors measured from localizer images. Results: Magnification factors from AP and PA localizers ranged from 0.79–1.11 and 1.35–0.91, respectively from lowest to highest positions (highest with phantom located closest to X-ray tube), with a smaller impact when using Lateral, PA+Lateral, Lateral+PA localizer types, all of which behaved similarly. For an average TCM strength and PA localizer, CTDI-vol ranged from 75% higher to 12% lower than the isocenter value for the lowest to highest table positions, respectively. For table positions ranging from lowest to highest, CTDI-vol ranged from −23% to 17% for AP, from −8% to 0.3% for lateral and from −7% to 1% for a combination of PA and Lateral in either order. Similar behavior was found for different TCM strengths, but effects were more pronounced for very strong compared with very weak modulation strengths. Conclusion: Patient off-centering substantially impacts radiation dose, which depends on the amount of vertical offcentering and type of the localizer used. The combination of PA and Lateral localizers is most robust against effects of patient off-centering.

  4. TU-H-CAMPUS-IeP2-05: Breast and Soft Tissue-Equivalent 3D Printed Phantoms for Imaging and Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Hintenlang, D; Terracino, B [University Florida, Gainesville, FL (United States)

    2016-06-15

    Purpose: The study has the goal to demonstrate that breast and soft tissue-equivalent phantoms for dosimetry applications in the diagnostic energy range can be fabricated using common 3D printing methods. Methods: 3D printing provides the opportunity to rapidly prototype uniquely designed objects from a variety of materials. Common 3D printers are usually limited to printing objects based on thermoplastic materials such as PLA, or ABS. The most commonly available plastic is PLA, which has a density significantly greater than soft tissue. We utilized a popular 3D printer to demonstrate that tissue specific phantom materials can be generated through the careful selection of 3D printing parameters. A series of stepwedges were designed and printed using a Makerbot Replicator2 3D printing system. The print file provides custom adjustment of the infill density, orientation and position of the object on the printer stage, selection of infill patterns, and other control parameters. The x-ray attenuation and uniformity of fabricated phantoms were evaluated and compared to common tissue-equivalent phantom materials, acrylic and BR12. X-ray exposure measurements were made using narrow beam geometry on a clinical mammography unit at 28 kVp on the series of phantoms. The 3D printed phantoms were imaged at 28 kVp to visualize the internal structure and uniformity in different planes of the phantoms. Results: By utilizing specific in-fill density and patterns we are able to produce a phantom closely matching the attenuation characteristics of BR12 at 28 kVp. The in-fill patterns used are heterogeneous, so a judicious selection of fill pattern and the orientation of the fill pattern must be made in order to obtain homogenous attenuation along the intended direction of beam propagation. Conclusions: By careful manipulation of the printing parameters, breast and soft tissue-equivalent phantoms appropriate for use at imaging energies can be fabricated using 3D printing techniques.

  5. CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli.

    Science.gov (United States)

    Díez-Villaseñor, César; Guzmán, Noemí M; Almendros, Cristóbal; García-Martínez, Jesús; Mojica, Francisco J M

    2013-05-01

    Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guide CRISPR-associated (Cas) proteins to degrade (interference) protospacers flanked by an adjacent motif in extrachomosomal DNA. During acquisition, selection of spacer-precursors adjoining the protospacer motif and proper orientation of the integrated fragment with respect to the leader (sequence leading transcription of the flanking CRISPR array) grant efficient interference by at least some CRISPR-Cas systems. This adaptive stage of the CRISPR action is poorly characterized, mainly due to the lack of appropriate genetic strategies to address its study and, at least in Escherichia coli, the need of Cas overproduction for insertion detection. In this work, we describe the development and application in Escherichia coli strains of an interference-independent assay based on engineered selectable CRISPR-spacer integration reporter plasmids. By using this tool without the constraint of interference or cas overexpression, we confirmed fundamental aspects of this process such as the critical requirement of Cas1 and Cas2 and the identity of the CTT protospacer motif for the E. coli K12 system. In addition, we defined the CWT motif for a non-K12 CRISPR-Cas variant, and obtained data supporting the implication of the leader in spacer orientation, the preferred acquisition from plasmids harboring cas genes and the occurrence of a sequential cleavage at the insertion site by a ruler mechanism.

  6. A Percepção de Estagiários em Diferentes IES do Brasil sobre a Supervisão

    Directory of Open Access Journals (Sweden)

    Ana Cláudia de Azevedo Peixoto

    Full Text Available Neste artigo, são apresentados os resultados referentes à análise qualitativa da percepção de estudantes de graduação em Psicologia envolvidos em algum tipo de estágio supervisionado . Um total de 312 alunos-estagiários dos 21 estados brasileiros respondeu o questionário disponibilizado em versão on-line para todas as instituições de ensino do país que aceitaram participar da pesquisa. Foi utilizada como instrumento para coleta dos dados a "Escala sobre a experiência de supervisão na ótica de estagiários de Psicologia", adaptada para o português, que engloba 27 questões fechadas e sete questões abertas. Para análise do conteúdo das respostas abertas, utilizou-se o software Sphinx Léxica (versão 5.0. Como resultado tem-se que a avaliação das supervisões por parte dos estagiários é bastante favorável aos supervisores e indicam que eles frequentemente apresentam comportamentos que favorecem o aprendizado e o aprimoramento do estagiário, tais como, apoiar o desejo de aprender do estagiário. Discute-se a percepção que o estagiário possui da relação com e seu supervisor no espaço da formação e instigam-se situações-problema na interação entre ele e seu supervisor.

  7. ABORDĂRI FILOZOFICE A CONCEPTELOR DE DREPTURI ALE OMULUI ŞI DE DEMOCRAŢIE ÎN PERIOADA ANTICĂ

    Directory of Open Access Journals (Sweden)

    Gheorghe Popa

    2008-05-01

    Full Text Available The human rights concept has its origins in the ancient Greek and Roman systems of ideas.All these extentions were made starting with the cultural, political and economical relationships in theancient Greeek, especially starting the year of 410 before Christ, when great psilosophers of the empire beganto understand and to analyse the already existing relations between the secular fortress state, religion andindividual.Concluding, ancient Greek is representative for that period of time through its great personalities suchas Hesiod with his Teogonia. Afterwards, the great man of law Solon ( 638-559 before Christ exterminatedslavery and was the first to debate upon the Athenian democracy.

  8. Valori în administrația publică: de la raționalitate la motivație în implementarea politicilor publice

    Directory of Open Access Journals (Sweden)

    Dorina ŢICU

    2011-06-01

    Full Text Available Public policies implementation involves the process of translating into practice draft policies in order to reach their final stage, when the issue brought up on the agenda by certain groups is resolved and the proposed solution becomes operational. Aside from the rational and the practical dimensions, policy implementation requires a number of elements that go beyond the theoretical and administrative frameworks reaching the subjective scope of actors involved in the process. Motivation of actors becomes a new dimension to the analysis of the process itself on a more complex field looming between public and private dimensions. The article aims to explore the subjective dimension of public policy implementation process and to see how the process is influenced by the dimension of individual motivation, beyond rationality.

  9. Las publicaciones científicas en México: retos y desafíos para IE Revista de Investigación Educativa de la REDIECH

    Directory of Open Access Journals (Sweden)

    Jesús Adolfo Trujillo Holguín

    2017-04-01

    Full Text Available Abrirse paso en el mundo de las publicaciones científicas en México es una tarea compleja, más si se trata de una que forme parte de un proyecto académico desarrollado al interior de una asociación civil sin fines de lucro –como lo es la Red de Investigadores Educativos Chihuahua–, donde los recursos económicos son escasos y la sustentabilidad financiera depende de la buena voluntad de sus socios. La tendencia de las publicaciones científicas en nuestro país es de migración del formato impreso al electrónico. Las plataformas editoriales de acceso abierto, como el Open Journal Systems (OJS, se convierten en mecanismos que facilitan la gestión editorial, sistematizando el envío de artículos, el registro de pares dictaminadores, el seguimiento de evaluaciones, la indexación en bases de datos y la transferencia de artículos en formatos para su publicación en otras plataformas.

  10. Curriculum, identity(ies and other stories: a look to the History of Africa and afro-descendants in Buenos Aires province context

    Directory of Open Access Journals (Sweden)

    Francisco Ramallo

    2017-03-01

    Full Text Available This article proposes to reflect about the reasons by which we believe that the history of Africa and the afrodescendants becomes important, especially in the teaching of History in the Argentinian high school. Our approach is framed within the analysis of new presences and absences of these cultures and towns in the curricular designs in the context of the Buenos Aires Province, given that in the last years attention was payed to the need of reviewing and renovating the school contents according to the demands of the contemporary society. There this other histories constituted as a new appearance and rupture in relation with the Eurocentered perspectives and contents that characterized the teaching of World History —no longer called Universal—. In the first place, after telling our tour of research, we establish the main aspects that characterize the approached curricular designs; subsequently, in the second stage, possible lines of work are established that contribute to overcome and critically review the African History and that of the afro-descendants in that normative and in the construction of a national identity.

  11. 41 CFR 301-11.17 - If my agency authorizes per diem reimbursement, will it reduce my M&IE allowance for a meal(s...

    Science.gov (United States)

    2010-07-01

    ... for a complimentary meal(s) provided by a hotel/motel? 301-11.17 Section 301-11.17 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false If my agency authorizes...

  12. A Comparative Prospective Study of Two Different Treatment Sequences i.e. Bottom Up-Inside Out and Topdown-Outside in, in the Treatment of Panfacial Fractures.

    Science.gov (United States)

    Degala, Saikrishna; Sundar, S Shyam; Mamata, K S

    2015-12-01

    To compare the sequence bottom-up inside-out with top-down outside-in, in the treatment of pan facial fractures and to evaluate the outcome of these approaches. The data from 11 patients with panfacial fracture are prospectively analysed. Five cases are treated with bottom-up approach and six patients with top-down approach. There were 11 male patients (six in top-down approach and five in bottom-up approach), ranging in age from 24 to 50 years. All injuries were result of RTA (n = 11, 100 %). Final treatment outcome was excellent in 3 (50 %), 1 (16 %) good and 2 (32 %) cases were fair in topdown approach, 3 (60 %) excellent and 2 (40 %) fair in bottom up approach with contingency coefficient value (P reconstruction of the remaining. Choice of the bottom-up inside-out or top-down outside-in sequence should be according to the pattern of fractures and preference of the surgeon. However, further controlled clinical trials, comparative studies with a larger sample size would be better to evaluate the final clinical outcome of individual techniques.

  13. SU-G-IeP1-12: Size Selective Arterial Cerebral Blood Volume Mapping Using Multiple Inversion Time Arterial Spin Labeling

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Y; Johnston, M; Whitlow, C [Wake Forest School of Medicine, Winston-salem, NC (United States); Liu, H [UT MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: To demonstrate the feasibility of a novel method for size specific arterial cerebral blood volume (aCBV) mapping using pseudo-continuous arterial spin labeling (PCASL), with multiple TI. Methods: Multiple PCASL images were obtained from a subject with TI of [300, 400, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000] ms. Each TI pair was averaged six times. Two scans were performed: one without a flow crusher gradient and the other with a crusher gradient (10cm/s in three directions) to remove signals from large arteries. Scan times were 5min. without a crusher gradient and 5.5 min with a crusher gradient. Non-linear fitting algorithm finds the minimum mean squared solution of per-voxel based aCBV, cerebral blood flow, and arterial transit time, and fits the data into a hemodynamic model that represents superposition of blood volume and flow components within a single voxel. Results: aCBV maps with a crusher gradient represent signals from medium and small sized arteries, while those without a crusher gradient represent signals from all sized arteries, indicating that flow crusher gradients can be effectively employed to achieve size-specific aCBV mapping. Regardless of flow crusher, the CBF and ATT maps are very similar in appearance. Conclusion: Quantitative size selective blood volume mapping controlled by a flow crusher is feasible without additional information because the ASL quantification process doesn’t require an arterial input function measured from a large artery. The size specific blood volume mapping is not interfered by sSignals from large arteries do not interfere with size specific aCBV mapping in the applications of interest in for applications in which only medium or small arteries are of interest.

  14. Rapid X-ray and optical variability in the X-ray selected BL Lacertae object IE 1402.3 + 0416

    International Nuclear Information System (INIS)

    Giommi, P.; Barr, P.; Gioia, I.M.; Maccacaro, T.; Schild, R.; Harvard-Smithsonian Center for Astrophysics, Cambridge)

    1986-01-01

    Results from X-ray and optical observations of the X-ray-discovered BL Lac object 1E 1402.3 + 0416 are presented, where the X-ray measurements were carried out with the Channel Multiplier Array (CMA) and Medium Energy experiment (ME) detectors on board Exosat. These measurements revealed an intensity decrease by a factor of two on a time scale of a few hours. At maximum flux, the source was significantly greater than at the time of the Einstein Image Proportional Counter (IPC) discovery observation. The 2-6 keV X-ray spectrum was determined by the ME experiment, and IPC, HRI, and CMA data were subsequently compared. The source varied over the years by a factor of five; its brightest state was within the last three years. It is noted that a redshift greater than 0.2 would require that anisotropic emission mechanisms be invoked. 18 references

  15. Sound velocity from inverted echo sounders (IES) in the western Pacific Ocean from 1992-08-26 to 1993-03-22 (NODC Accession 9300159)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains inverted echo sounder data collected from two stations in the western Pacific, TPW nominally @ 2S and 154E and TPE nominally @ 2S and 164E....

  16. Positive and negative feedback in the earthquake cycIe: the role of pore fluids on states of criticality in the crust

    Directory of Open Access Journals (Sweden)

    P. R. Sammonds

    1994-06-01

    Full Text Available Fluids exert a strong physical and chemical control on local processes of rock fracture and friction. For example they may accelerate fracture by stress corrosion reactions or the development of overpressure (a form of positive feedback, or retard fracture by time-dependent stress relaxation or dilatant hardening (negative feed-back, thereby introducing a variable degree of local force conservation into the process. In particular the valve action of dynamic faulting may be important in tuning the Earth to a metastable state of incipient failure on all scales over several cycles, similar to current models of Self-Organised Criticality (SOC as a paradigm for eartiquakes However laboratory results suggest that ordered fluctuations about this state may occur in a single cycle due to non conservative processes involving fluids which have the potential to be recognised, at least in the short term, in the scaling properties of earthquake statistics. Here we describe a 2-D cellular automaton which uses local rules of positive and negative feedback to model the effect of fluids on failure in a heterogeneous medium in a single earthquake cycle. The model successfully predicts the observed fractal distribution of fractures, with a negative correlation between the predicted seismic b-value and the local crack extension force G. Such a negative correlation is found in laboratory tests involving (a fluid-assisted crack growth in tension (b water-saturated compressional deformation, and (c in field results on an intermediate scale from hydraulic mining-induced seismicity all cases where G can be determined independently, and where the physical and chemical action of pore fluids is to varying degrees a controlled variable. For a finite local hardening mechanism (negative feedback, the model exhibits a systematic increase followed by a decrease in the seismic b-value as macroscopic failure is approached, similar to that found in water-saturated laboratory tests under controlled «undrained» conditions, and where dilatancy hardening is independently known to be a local mechanism of negative feedback. A similar pattern is suggested from selected field observations from natural seismicity, albeit with a lesser degree of statistical significance.

  17. Areva revenue growth in the first quarter of 2010: 8.4% like-for-like, i.e. 1.936 billion euros

    International Nuclear Information System (INIS)

    2010-01-01

    The group's first quarter 2010 consolidated revenue rose 6.5% to 1.936 billion euros (+8.4% LFL) compared with the first quarter of 2009. Growth was driven by the Reactors and Services Business Group (+18.0% LFL). Revenue from exports was up 16.6% to 1.089 billion euros, representing 56.2% of total revenue. Foreign exchange had a negative impact of 26 million euros. Changes in consolidation scope were negligible during the period. The group's backlog of 43.6 billion euros at March 31, 2010 was stable in relation to December 31, 2009. Growth in the backlog of the Reactors and Services Business Group helped offset the drawdown of the backlog in the Back End Business Group as contracts were completed. For the full year of 2010, the group confirms its outlook for significant backlog and revenue growth, rising operating income, and a strong increase in net income attributable to owners of the parent. Mining/Front End Business Group: The Mining/Front End BG reported first quarter 2010 revenue of 674 million euros, which was stable on a reported basis and up 3.5% LFL1. Foreign exchange had a negative impact of 16 million euros. - In Mining, quarterly revenue was driven by volume growth due to a favorable delivery schedule. - In Enrichment and Fuel, volumes were down compared with the first quarter of 2009, particularly due to time-lag in customer deliveries. Reactors and Services Business Group: Revenue for the Reactors and Services BG was up 16.4% in the first quarter of 2010 (up 18.0% LFL1), to 775 million euros. Foreign exchange had a negative impact of 10 million euros. - The New Builds Business reported strong growth due to significant progress on major reactor construction projects, particularly Taishan in China. - Installed Base Business was also up due to buoyant engineering operations, particularly in Germany, and to the more favorable seasonality of unit outage campaigns than in the first quarter of 2009. Back End Business Group: First quarter 2010 revenue for the Back End BG reached 413 million euros, stable compared with that of the first quarter of 2009 (416 million euros). Renewable Energies Business Group: First quarter 2010 revenue from the Renewable Energies BG was up sharply (+61.8% LFL) compared with the first quarter of 2009, at 33 million euros, due to brisk business in Bio-energies and ramp-up of wind energy projects

  18. Stress and displacement analysis of a core plate, i.e. grid-perforated plate compound, modelled as an equivalent beam system

    International Nuclear Information System (INIS)

    Frank, R.; Engel, R.

    1979-01-01

    The core support plate is a very important component of the reactor pressure vessel internals. Therefore, an exact stress analysis is desired. This analysis will cause high computer costs with a detailed FEM-model because of the complexity of this compound system. In this paper, a method is suggested to solve the problem with a much cheaper beam element model. The main problem is to establish an equivalent beam system with nearly the same stiffness property as the perforated circular plate stiffened by a grid. Furthermore, the system must allow to determine the maximum stresses with sufficient accuracy. The calculation of the equivalent beam stiffness is based on the analysis of perforated plates by T. SLOT and W.J. O'DONNELL. This analysis method utilizes the concept of the equivalent solid plate. In this method, the perforated plate is replaced by a solid one which is geometrically similar to the perforated plate but has modified values of the elastic constants. The simple equivalent beam system of one half of the core support plate (symmetry) was loaded with a pressure difference and stresses and displacements were analysed. After that, these results were compared with the stress and displacement analysis of a part of the real structure. This substructure was discretized by three-dimensional 20-node brick-elements. The comparison of the results of the two models shows that the stresses and displacements, calculated with the simple beam model, are in good agreement with those of the real structure. (orig.)

  19. Las lenguas inmigrantes en el IES Eclipse: un análisis desde la política lingüística de la Comunidad de Madrid

    Directory of Open Access Journals (Sweden)

    Isabel Solís Casco

    2017-04-01

    Full Text Available La política lingüística educativa europea se caracteriza por el progresivo fomento del multilingüismo entre sus ciudadanos y el reconocimiento de la riqueza cultural de las lenguas asentadas en Europa. Sin embargo, no todas las lenguas han obtenido el mismo grado de promoción ni de reconocimiento en los sistemas educativos europeos. En el caso de las lenguas inmigrantes su estatus y grado de visibilidad apenas ha variado desde que en los setenta se publicaron las primeras normas para su regulación. A través de un estudio de caso, que forma parte de una investigación más amplia sobre la política lingüística educativa llevada a cabo en la Comunidad de Madrid, se estudia la visibilidad de las lenguas inmigrantes en un centro educativo de Secundaria y la ideología lingüística respecto a estas lenguas. Siguiendo el método etnográfico, a partir del estudio de documentos oficiales del centro y del paisaje lingüístico del instituto, se llega a la conclusión de que en el contexto educativo prevalece una ideología lingüística de invisibilización de las lenguas inmigrantes, a pesar de la normativa y de los estudios que han demostrado los beneficios de valorar las lenguas inmigrantes en la escuela. European educational language policy has moved from monolingualism to the promotion of multilingualism among Europeans and to the acknowledgement of the cultural richness of the languages found in Europe. Nevertheless, not all the languages have achieved the same degree of support or acknowledgement in European educational systems. For example, neither the status of languages spoken by immigrants nor their and their presence in classrooms has increased since the first laws governing their use in educational establishments were passed in the late seventies. In this article, through a case study forming part of a larger study regarding educational language-policy undertaken in the Madrid region, the presence of immigrant mother-tongues at a secondary school and the language ideology with respect to these languages will be analyzed. Using the ethnographic method and based on an examination of the official documents at the secondary school and the language environment found there, one reaches the conclusion that the educational context is characterized by a language ideology that renders immigrant mother-tongues invisible, despite the legislation passed and the studies undertaken which have demonstrated the benefits of valuing the mother tongues of immigrants in the educational setting.

  20. SU-G-IeP4-09: Method of Human Eye Aberration Measurement Using Plenoptic Camera Over Large Field of View

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Yang; Wang, Ruixing; Ma, Haotong; Zhang, Xuanzhe; Ning, Yu; Xu, Xiaojun [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha (China)

    2016-06-15

    Purpose: The measurement based on Shack-Hartmann wave-front sensor(WFS), obtaining both the high and low order wave-front aberrations simultaneously and accurately, has been applied in the detection of human eyes aberration in recent years. However, Its application is limited by the small field of view (FOV), slight eye movement leads the optical bacon image exceeds the lenslet array which result in uncertain detection error. To overcome difficulties of precise eye location, the capacity of detecting eye wave-front aberration over FOV much larger than simply a single conjugate Hartmann WFS accurately and simultaneously is demanded. Methods: Plenoptic camera’s lenslet array subdivides the aperture light-field in spatial frequency domain, capture the 4-D light-field information. Data recorded by plenoptic cameras can be used to extract the wave-front phases associated to the eyes aberration. The corresponding theoretical model and simulation system is built up in this article to discuss wave-front measurement performance when utilizing plenoptic camera as wave-front sensor. Results: The simulation results indicate that the plenoptic wave-front method can obtain both the high and low order eyes wave-front aberration with the same accuracy as conventional system in single visual angle detectionand over FOV much larger than simply a single conjugate Hartmann systems. Meanwhile, simulation results show that detection of eye aberrations wave-front in different visual angle can be achieved effectively and simultaneously by plenoptic method, by both point and extended optical beacon from the eye. Conclusion: Plenoptic wave-front method possesses the feasibility in eye aberrations wave-front detection. With larger FOV, the method can effectively reduce the detection error brought by imprecise eye location and simplify the eye aberrations wave-front detection system comparing with which based on Shack-Hartmann WFS. Unique advantage of the plenoptic method lies in obtaining wave-front in different visual angle simultaneously, which provides an approach in building up 3-D model of eye refractor tomographically. Funded by the key Laboratory of High Power Laser and Physics, CAS Research Project of National University of Defense Technology No. JC13-07-01; National Natural Science Foundation of China No. 61205144.

  1. Investigation of Hotline Allegation of a Questionable Intelligence Activity Concerning the Joint Improvised Explosive Device Defeat Organization (JIEDDO), Counter-IED Operations/Intelligence Integration Center (COIC) (REDACTED)

    Science.gov (United States)

    2014-04-04

    Secretary of Defense for lntelligenre Oversight ATSD (10) m::~ intain that DoDD 2000.1 9E granted JIED DO thP authority to conduct intelligence...arrival, receive annual refresher training in 10 and are formally tested on their knowledge tailored to specifi c unit miss ions. Formal testing developed...one or more of thP natural or social sclencPs, engineering, or milltary science, but do not demand, as a primary qualifica tion requirement, f ull

  2. SU-G-IeP2-05: Effect of Localizer Type and Patient Off-Centering On CT Radiation Dose with Use of Automatic Tube Current Modulation

    International Nuclear Information System (INIS)

    Ruan, C; Sodickson, A; Hamberg, L

    2016-01-01

    Purpose: Apparent patient size in CT localizers varies with localizer type and patient positioning, resulting in variation in effective mAs as guided by Tube Current Modulation (TCM). Our aim was to investigate the effects of vertical off-centering on CTDI-vol when using different localizer types and TCM strengths. Methods: A CTDI body phantom was scanned using an abdominal protocol with three TCM strengths (Siemens Definition AS40, CAREDose4D; very weak, average, very strong). Data was acquired at 11 table height positions; with phantom center at isocenter and at 10 other positions between 142mm below and 53mm above. At each position, scans were acquired using 5 different localizer types: PA, AP, Lateral, PA+Lateral, and Lateral+PA. CTDI-vol was recorded for the 165 combinations of table height, localizer type, and TCM strength, and magnification factors measured from localizer images. Results: Magnification factors from AP and PA localizers ranged from 0.79–1.11 and 1.35–0.91, respectively from lowest to highest positions (highest with phantom located closest to X-ray tube), with a smaller impact when using Lateral, PA+Lateral, Lateral+PA localizer types, all of which behaved similarly. For an average TCM strength and PA localizer, CTDI-vol ranged from 75% higher to 12% lower than the isocenter value for the lowest to highest table positions, respectively. For table positions ranging from lowest to highest, CTDI-vol ranged from −23% to 17% for AP, from −8% to 0.3% for lateral and from −7% to 1% for a combination of PA and Lateral in either order. Similar behavior was found for different TCM strengths, but effects were more pronounced for very strong compared with very weak modulation strengths. Conclusion: Patient off-centering substantially impacts radiation dose, which depends on the amount of vertical offcentering and type of the localizer used. The combination of PA and Lateral localizers is most robust against effects of patient off-centering.

  3. SU-G-IeP3-05: Effects of Image Receptor Technology and Dose Reduction Software On Radiation Dose Estimates for Fluoroscopically-Guided Interventional (FGI) Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Merritt, Z; Dave, J; Eschelman, D; Gonsalves, C [Thomas Jefferson University, Philadelphia, PA (United States)

    2016-06-15

    Purpose: To investigate the effects of image receptor technology and dose reduction software on radiation dose estimates for most frequently performed fluoroscopically-guided interventional (FGI) procedures at a tertiary health care center. Methods: IRB approval was obtained for retrospective analysis of FGI procedures performed in the interventional radiology suites between January-2011 and December-2015. This included procedures performed using image-intensifier (II) based systems which were subsequently replaced, flat-panel-detector (FPD) based systems which were later upgraded with ClarityIQ dose reduction software (Philips Healthcare) and relatively new FPD system already equipped with ClarityIQ. Post procedure, technologists entered system-reported cumulative air kerma (CAK) and kerma-area product (KAP; only KAP for II based systems) in RIS; these values were analyzed. Data pre-processing included correcting typographical errors and cross-verifying CAK and KAP. The most frequent high and low dose FGI procedures were identified and corresponding CAK and KAP values were compared. Results: Out of 27,251 procedures within this time period, most frequent high and low dose procedures were chemo/immuno-embolization (n=1967) and abscess drainage (n=1821). Mean KAP for embolization and abscess drainage procedures were 260,657, 310,304 and 94,908 mGycm{sup 2}, and 14,497, 15,040 and 6307 mGycm{sup 2} using II-, FPD- and FPD with ClarityIQ- based systems, respectively. Statistically significant differences were observed in KAP values for embolization procedures with respect to different systems but for abscess drainage procedures significant differences were only noted between systems with FPD and FPD with ClarityIQ (p<0.05). Mean CAK reduced significantly from 823 to 308 mGy and from 43 to 21 mGy for embolization and abscess drainage procedures, respectively, in transitioning to FPD systems with ClarityIQ (p<0.05). Conclusion: While transitioning from II- to FPD- based systems was not associated with dose reduction for the most frequently performed FGI procedures, substantial dose reduction was noted with relatively newer systems and dose reduction software.

  4. SU-G-IeP1-15: Towards Accurate Cerebral Blood Flow Quantification with Distortion- Corrected Pseudo-Continuous Arterial Spin Labeling

    Energy Technology Data Exchange (ETDEWEB)

    Hoff, M; Rane-Levandovsky, S; Andre, J [University of Washington, Seattle, WA (United States)

    2016-06-15

    Purpose: Traditional arterial spin labeling (ASL) acquisitions with echo planar imaging (EPI) readouts suffer from image distortion due to susceptibility effects, compromising ASL’s ability to accurately quantify cerebral blood flow (CBF) and assess disease-specific patterns associated with CBF abnormalities. Phase labeling for additional coordinate encoding (PLACE) can remove image distortion; our goal is to apply PLACE to improve the quantitative accuracy of ASL CBF in humans. Methods: Four subjects were imaged on a 3T Philips Ingenia scanner using a 16-channel receive coil with a 21/21/10cm (frequency/phase/slice direction) field-of-view. An ASL sequence with a pseudo-continuous ASL (pCASL) labeling scheme was employed to acquire thirty dynamics of single-shot EPI data, with control and label datasets for all dynamics, and PLACE gradients applied on odd dynamics. Parameters included a post-labeling delay = 2s, label duration = 1.8s, flip angle = 90°, TR/TE = 5000/23.5ms, and 2.9/2.9/5.0mm (frequency/phase/slice direction) voxel size. “M0” EPI-reference images and T1-weighted spin-echo images with 0.8/1.0/3.3mm (frequency/phase/slice directions) voxel size were also acquired. Complex conjugate image products of pCASL odd and even dynamics were formed, a linear phase ramp applied, and data expanded and smoothed. Data phase was extracted to map control, label, and M0 magnitude image pixels to their undistorted locations, and images were rebinned to original size. All images were corrected for motion artifacts in FSL 5.0. pCASL images were registered to M0 images, and control and label images were subtracted to compute quantitative CBF maps. Results: pCASL image and CBF map distortions were removed by PLACE in all subjects. Corrected images conformed well to the anatomical T1-weighted reference image, and deviations in corrected CBF maps were evident. Conclusion: Eliminating pCASL distortion with PLACE can improve CBF quantification accuracy using minimal pulse sequence modifications and no additional scan time, improving ASL’s clinical applicability.

  5. SU-G-IeP2-12: The Effect of Iterative Reconstruction and CT Tube Voltage On Hounsfield Unit Values of Iodinated Contrast

    Energy Technology Data Exchange (ETDEWEB)

    Ogden, K; Greene-Donnelly, K; Vallabhaneni, D; Scalzetti, E [SUNY Upstate Medical University, Syracuse, New York (United States)

    2016-06-15

    Purpose: To investigate the effects of changing iterative reconstruction strength and tube voltage on Hounsfield Unit (HU) values of varying concentrations of Iodinated contrast medium in a phantom. Method: Iodinated contrast (Omnipaque 300, GE Healthcare, Princeton NJ) was diluted with distilled water to concentrations of 0.6, 0.9, 1.8, 3.6, 7.2, and 10.8 mg/mL of Iodine. The solutions were scanned in a patient equivalent water phantom on two MDCT scanners: VCT 64 slice (GE Medical Systems, Waukesha, WI) and an Aquilion One 320 slice scanner (Toshiba America Medical Systems, Tustin CA). The phantom was scanned at 80, 100, 120, 140 kV using 400, 255, 180, and 130 mAs, respectively, for the VCT scanner, and 80, 100, 120, and 135 kV using 400, 250, 200, and 150 mAs, respectively, on the Aquilion One. Images were reconstructed at 2.5 mm (VCT) and 0.5 mm (Aquilion One). The VCT images were reconstructed using Advanced Statistical Iterative Reconstruction (ASIR) at 6 different strengths: 0%, 20%, 40%, 60%, 80%, and 100%. Aquilion One images were reconstructed using Adaptive Iterative Dose Reduction (AIDR) at 4 strengths: no AIDR, Weak AIDR, Standard AIDR, and Strong AIDR. Regions of interest (ROIs) were drawn on the images to measure the HU values and standard deviations of the diluted contrast. Second order polynomials were used to fit the HU values as a function of Iodine concentration. Results: For both scanners, there was no significant effect of changing the iterative reconstruction strength. The polynomial fits yielded goodness-of-fit (R2) values averaging 0.997. Conclusion: Changing the strength of the iterative reconstruction has no significant effect on the HU values of Iodinated contrast in a tissue-equivalent phantom. Fit values of HU vs Iodine concentration are useful in quantitative imaging protocols such as the determination of cardiac output from time-density curves in the main pulmonary artery.

  6. MO-FG-CAMPUS-IeP1-01: Alternative K-Edge Filters for Low-Energy Image Acquisition in Contrast Enhanced Spectral Mammography

    Energy Technology Data Exchange (ETDEWEB)

    Shrestha, S; Vedantham, S; Karellas, A [University of Massachusetts Medical School, Worcester, MA (United States)

    2016-06-15

    Purpose: In Contrast Enhanced Spectral Mammography (CESM), Rh filter is often used during low-energy image acquisition. The potential for using Ag, In and Sn filters, which exhibit K-edge closer to, and just below that of Iodine, instead of the Rh filter, was investigated for the low-energy image acquisition. Methods: Analytical computations of the half-value thickness (HVT) and the photon fluence per mAs (photons/mm2/mAs) for 50µm Rh were compared with other potential K-edge filters (Ag, In and Sn), all with K-absorption edge below that of Iodine. Two strategies were investigated: fixed kVp and filter thickness (50µm for all filters) resulting in HVT variation, and fixed kVp and HVT resulting in variation in Ag, In and Sn thickness. Monte Carlo simulations (GEANT4) were conducted to determine if the scatter-to-primary ratio (SPR) and the point spread function of scatter (scatter PSF) differed between Rh and other K-edge filters. Results: Ag, In and Sn filters (50µm thick) increased photon fluence/mAs by 1.3–1.4, 1.8–2, and 1.7–2 at 28-32 kVp compared to 50µm Rh, which could decrease exposure time. Additionally, the fraction of spectra closer to and just below Iodine’s K-edge increased with these filters, which could improve post-subtraction image contrast. For HVT matched to 50µm Rh filtered spectra, the thickness range for Ag, In, and Sn were (41,44)µm, (49,55)µm and (45,53)µm, and increased photon fluence/mAs by 1.5–1.7, 1.6–2, and 1.6–2.2, respectively. Monte Carlo simulations showed that neither the SPR nor the scatter PSF of Ag, In and Sn differed from Rh, indicating no additional detriment due to x-ray scatter. Conclusion: The use of Ag, In and Sn filters for low-energy image acquisition in CESM is potentially feasible and could decrease exposure time and may improve post-subtraction image contrast. Effect of these filters on radiation dose, contrast, noise and associated metrics are being investigated. Funding Support: Supported in part by NIH R01CA195512. The contents are solely the responsibility of the authors and do not reflect the official views of the NIH or NCI.

  7. Estudio de caso sobre la cultura democrática en el IES La Caleta de la ciudad de Cádiz.

    OpenAIRE

    Oliva Alfaro, Jose Manuel

    2015-01-01

    Mediante un estudio de caso se profundiza en el análisis de la cultura democrática en un Instituto de Educación Secundaria de la ciudad de Cádiz, y se hace desde los referentes conceptuales de la Cultura de Paz y la No Violencia sobre el modo de entender y afrontar los conflictos y la convivencia.

  8. SU-G-IeP4-04: DD-Neutron Source Collimation for Neutron Stimulated Emission Computed Tomography: A Monte Carlo Simulation Study

    Energy Technology Data Exchange (ETDEWEB)

    Fong, G; Kapadia, A [Carl E Ravin Advanced Imaging Laboratories, Durham, North Carolina (United States)

    2016-06-15

    Purpose: To optimize collimation and shielding for a deuterium-deuterium (DD) neutron generator for an inexpensive and compact clinical neutron imaging system. The envisioned application is cancer diagnosis through Neutron Stimulated Emission Computed Tomography (NSECT). Methods: Collimator designs were tested with an isotropic 2.5 MeV neutron source through GEANT4 simulations. The collimator is a 52×52×52 cm{sup 3} polyethylene block coupled with a 1 cm lead sheet in sequence. Composite opening was modeled into the collimator to permit passage of neutrons. The opening varied in shape (cylindrical vs. tapered), size (1–5 cm source-side and target-side openings) and aperture placements (13–39 cm from source-side). Spatial and energy distribution of neutrons and gammas were tracked from each collimator design. Parameters analyzed were primary beam width (FWHM), divergence, and efficiency (percent transmission) for different configurations of the collimator. Select resultant outputs were then used for simulated NSECT imaging of a virtual breast phantom containing a 2.5 cm diameter tumor to assess the effect of the collimator on spatial resolution, noise, and scan time. Finally, composite shielding enclosure made of polyethylene and lead was designed and evaluated to block 99.99% of neutron and gamma radiation generated in the system. Results: Analysis of primary beam indicated the beam-width is linear to the aperture size. Increasing source-side opening allowed at least 20% more neutron throughput for all designs relative to the cylindrical openings. Maximum throughput for all designs was 364% relative to cylindrical openings. Conclusion: The work indicates potential for collimating and shielding a DD neutron generator for use in a clinical NSECT system. The proposed collimator designs produced a well-defined collimated neutron beam that can be used to image samples of interest with millimeter resolution. Balance in output efficiency, noise reduction, and scan time should be considered to determine the optimal design for specific NSECT applications.

  9. J. Laužiko edukacinės idėjos tąsa ieškant optimalaus sociopedagoginio poveikio modelių

    OpenAIRE

    Kvieskienė, Giedrė; Merfeldaitė, Odeta

    2003-01-01

    On the basis of J. Laužikas’ ideas of social education at school, the article analyses the model of activity used by a social pedagogical team at school; examines the possibilities for the community of solving social pedagogical problems (interaction between educatees and the team); presents the sociopedagogical team module – interaction and functions of team members; and analyses the role of the main team leader – social pedagogue.

  10. TU-H-CAMPUS-IeP2-05: Breast and Soft Tissue-Equivalent 3D Printed Phantoms for Imaging and Dosimetry

    International Nuclear Information System (INIS)

    Hintenlang, D; Terracino, B

    2016-01-01

    Purpose: The study has the goal to demonstrate that breast and soft tissue-equivalent phantoms for dosimetry applications in the diagnostic energy range can be fabricated using common 3D printing methods. Methods: 3D printing provides the opportunity to rapidly prototype uniquely designed objects from a variety of materials. Common 3D printers are usually limited to printing objects based on thermoplastic materials such as PLA, or ABS. The most commonly available plastic is PLA, which has a density significantly greater than soft tissue. We utilized a popular 3D printer to demonstrate that tissue specific phantom materials can be generated through the careful selection of 3D printing parameters. A series of stepwedges were designed and printed using a Makerbot Replicator2 3D printing system. The print file provides custom adjustment of the infill density, orientation and position of the object on the printer stage, selection of infill patterns, and other control parameters. The x-ray attenuation and uniformity of fabricated phantoms were evaluated and compared to common tissue-equivalent phantom materials, acrylic and BR12. X-ray exposure measurements were made using narrow beam geometry on a clinical mammography unit at 28 kVp on the series of phantoms. The 3D printed phantoms were imaged at 28 kVp to visualize the internal structure and uniformity in different planes of the phantoms. Results: By utilizing specific in-fill density and patterns we are able to produce a phantom closely matching the attenuation characteristics of BR12 at 28 kVp. The in-fill patterns used are heterogeneous, so a judicious selection of fill pattern and the orientation of the fill pattern must be made in order to obtain homogenous attenuation along the intended direction of beam propagation. Conclusions: By careful manipulation of the printing parameters, breast and soft tissue-equivalent phantoms appropriate for use at imaging energies can be fabricated using 3D printing techniques.

  11. Género y orientación vocacional. Sistematización de experiencia docente en el IED Lorencita Villegas de Santos

    OpenAIRE

    Chamorro Salas, Magda Elena

    2017-01-01

    En los últimos años se ha ampliado de manera considerable el acceso de la mujer a la educación básica y media, pero poco se ha avanzado en su incorporación frente a los distintos escenarios de la sociedad colombiana. Aún peor, a pesar de la alta presencia de la mujer en el magisterio, la escuela sigue reproduciendo estereotipos culturales que han configurado relaciones de género que tienden a profundizar la desigualdad, el estigma y, en muchas ocasiones, la violencia en contra de la mujer. Po...

  12. Desempeño docente y satisfacción/insatisfacción laboral del profesorado de nivel primario de la I.E. Alfredo Bonifaz Fonseca - 2015

    OpenAIRE

    Ramírez Silva, Dante Alexander.

    2015-01-01

    El objetivo de la presente investigación fue determinar de qué manera se relaciona el desempeño docente con la satisfacción/insatisfacción laboral de los profesores del nivel primario de la LE. "Alfredo Bonifaz Fonseca". El enfoque fue de una investigación cuantitativa, de tipo descriptivo correlacional, de diseño no experimental. La población estuvo compuesta por sesenta y cuatro (64) docentes, de los cuales se tomó una muestra de cincuenta y cinco (55) participantes, obtenidos por muestreo ...

  13. TU-H-CAMPUS-IeP1-05: A Framework for the Analytic Calculation of Patient-Specific Dose Distribution Due to CBCT Scan for IGRT

    International Nuclear Information System (INIS)

    Youn, H; Jeon, H; Nam, J; Lee, J; Lee, J; Kim, J; Kim, H; Cho, M; Yun, S; Park, D; Kim, W; Ki, Y; Kim, D

    2016-01-01

    Purpose: To investigate the feasibility of an analytic framework to estimate patients’ absorbed dose distribution owing to daily cone-beam CT scan for image-guided radiation treatment. Methods: To compute total absorbed dose distribution, we separated the framework into primary and scattered dose calculations. Using the source parameters such as voltage, current, and bowtie filtration, for the primary dose calculation, we simulated the forward projection from the source to each voxel of an imaging object including some inhomogeneous inserts. Then we calculated the primary absorbed dose at each voxel based on the absorption probability deduced from the HU values and Beer’s law. In sequence, all voxels constructing the phantom were regarded as secondary sources to radiate scattered photons for scattered dose calculation. Details of forward projection were identical to that of the previous step. The secondary source intensities were given by using scatter-to- primary ratios provided by NIST. In addition, we compared the analytically calculated dose distribution with their Monte Carlo simulation results. Results: The suggested framework for absorbed dose estimation successfully provided the primary and secondary dose distributions of the phantom. Moreover, our analytic dose calculations and Monte Carlo calculations were well agreed each other even near the inhomogeneous inserts. Conclusion: This work indicated that our framework can be an effective monitor to estimate a patient’s exposure owing to cone-beam CT scan for image-guided radiation treatment. Therefore, we expected that the patient’s over-exposure during IGRT might be prevented by our framework.

  14. Local and regional irradiation and brief reduced-dose chemotherapy for non-Hodgkin'n lymphoma (stage IE, IIE) of Waldeyer's ring with adult diseases

    International Nuclear Information System (INIS)

    Oguchi, Masahiko; Shikama, Naoto; Gomi, Koutarou; Izuno, Itaru; Takei, Kazuyoshi; Sasaki, Shigeru; Kiyono, Kunihiro

    1997-01-01

    Usually, the middle-aged patients with non-Hodgkin's lymphoma and concomitant other adult diseases can not be tolerable for intensive chemotherapy. Then we introduced a new regimen composed of radiation for local and surrounding lymph node areas, and brief reduced-dose chemotherapy into treatment for such patients. Thirty-eight patients with Stage I E or Stage II E non-Hodgkin's lymphoma of the Waldeyer's ring were a core of this study. Histopathologically they were diagnosed as diffuse intermediate grade. In addition, they suffered from other adult diseases such as cardiovascular diseases, cereblovascular disorders, diabetes mellitus, chronic liver diseases, etc. They were treated by the combined modality composed of reduced-dose chemotherapy (70%-ACOP: 2 cycles or 70%-MACOP-B: 8 weeks) and regional lymph node irradiation (30 Gy) puls boost irradiation (10 Gy) to involved area (total 40 Gy). No relapses were observed in the radiation field, the 5-year disease-free survival rate and cause-specific survival rate for all patients were 85.7% and 91.4%, respectively. There were no differences of the 5-year disease-free survival rate between stage I E and II E , among the pathological subtypes, among the complications and etc. The regimen composed of regional lymph node irradiation (30 Gy) puls boost irradiation (10 Gy) to involved area (total 40 Gy) and reduced-dose chemotherapy (70%-dose ACOP, 70%-dose MACOP-B) is a safe and useful approach to treatment for diffuse intermediate grade of B cell lymphoma in middle-aged patients having other adult diseases. (author)

  15. In d ia n A cademyof S c ie nces , B anga lo re In d ia n N a tio nal S c ...

    Indian Academy of Sciences (India)

    Srimath

    2008-10-30

    Oct 30, 2008 ... quoted in the hard copy of the application which is to be sent and also in the letter of recommendation to be ... 3. Full home address (if different from col.2). 7. Telephone. Mobile. 4. Gender: M / F. 8. ... Title of thesis. (f) Others.

  16. Programa de estrategias didácticas motivacionales para fortalecer la Inteligencia Emocional en los estudiantes de la IE N° 10253 de Cutervo-2016

    OpenAIRE

    Rojas Salas, Lady Yojany

    2016-01-01

    Diversas investigaciones indican que una de los principales problemas de los estudiantes de Educación Primaria es el escaso manejo estrategias didácticas motivacionales que son de suma importancia para el correcto manejo de las emociones. Por lo que los conflictos en las aulas surgen debido a que los estudiantes no saben manejar sus emociones, puesto que no posee las herramientas necesarias que le permita reaccionar de manera correcta ante diversas situaciones de conflicto. Estos casos se vie...

  17. Diaspora în cadrul binomului „migrație și dezvoltare”: aspecte internaționale și naționale

    Directory of Open Access Journals (Sweden)

    Rodica RUSU

    2017-12-01

    Full Text Available Acest articol subliniază rolul migranților și membrilor diasporei ca agenți ai dezvoltării. Migrația este considerată ca fiind unul dintre catalizatorii reducerii inegalității globale. Cetățenii care locuiesc în străinătate și sunt organizați în comunitățile diasporei sunt văzuți ca posibili parteneri pentru dezvoltarea economică, politică, socială și culturală. Gradul de integrare și succes în societatea-gazdă contribuie la capacitatea diasporei de a contribui și de a influența sentimentul de eficacitate al membrilor diasporei. Angajamentul poate crește în timp, odată ce membrii diasporei vor deveni integrați în societatea-gazdă și își vor dezvolta în continuare abilitățile și cunoștințele.

  18. Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the <i>E. coli FMN riboswitch

    Energy Technology Data Exchange (ETDEWEB)

    Howe, John A.; Xiao, Li; Fischmann, Thierry O.; Wang, Hao; Tang, Haifeng; Villafania, Artjohn; Zhang, Rumin; Barbieri, Christopher M.; Roemer, Terry (Merck)

    2016-08-02

    Bacterial riboswitches are non-coding RNA structural elements that direct gene expression in numerous metabolic pathways. The key regulatory roles of riboswitches, and the urgent need for new classes of antibiotics to treat multi-drug resistant bacteria, has led to efforts to develop small-molecules that mimic natural riboswitch ligands to inhibit metabolic pathways and bacterial growth. Recently, we reported the results of a phenotypic screen targeting the riboflavin biosynthesis pathway in the Gram-negative bacteria Escherichia coli that led to the identification of ribocil, a small molecule inhibitor of the flavin mononucleotide (FMN) riboswitch controlling expression of this biosynthetic pathway. Although ribocil is structurally distinct from FMN, ribocil functions as a potent and highly selective synthetic mimic of the natural ligand to repress riboswitch-mediated ribB gene expression and inhibit bacterial growth both in vitro and in vivo. Herein, we expand our analysis of ribocil; including mode of binding in the FMN binding pocket of the riboswitch, mechanisms of resistance and structure-activity relationship guided efforts to generate more potent analogs.

  19. Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition

    NARCIS (Netherlands)

    Westra, E.R.; Semenova, E.; Datsenko, K.A.; Jackson, R.N.; Wiedenheft, B.; Severinov, K.; Brouns, S.J.J.

    2013-01-01

    Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts

  20. Efectul unor plante medicinale asupra profilului lipidic și al activității enzimelor hepatice în comparație cu statinele

    Directory of Open Access Journals (Sweden)

    Mohamed, Erieg Abdul Wahab

    2017-12-01

    Full Text Available In the recent decades, hyperlipidemia has considerably increased with the development of machine life. It has been accompanied by diseases such as hypothyroidism, liver and kidney diseases, diabetes, chronic kidney disease, as well as obesity and can cause complications such as atherosclerosis, hypertension, increased risk of stroke, and fatty liver disease. Currently, the prevalence of hyperlipidemia and its related diseases has increased in developing as well as developed countries. In the most cases, drug therapy is needed to control and treat hyperlipidemia. However, problems related to conventional drugs including adverse events (digestive complications such as indigestion, bloating, constipation along with neurologic complications such as myopathy and neuralgia. In addition to the hepatotoxicity and nephrotoxicity. Growing rate of hyperlipidemia and its related complications despite the availability of these drugs dissatisfaction of patients with these drugs, emergence of complications induced by their prolonged use, as well as high drug costs have increased tendency to complementary and alternative treatments for the control and treatment of this disease. In this regard, traditional medical information of each region as well as identification and utilization of medicinal plants of that area may have an important role in identifying new medicines with plant origin for alternative treatments. In addition to endogenous antioxidants, there are exogenous antioxidants. The beneficial effects of foods have been linked to the presence of bioactive compounds and other nutrients. Examples of biomolecules that have antioxidant potential are phenolic compounds such as isoflavones, phenolic acids, catechins, chlorogenic acids, anthocyanins, and terpenes. Thus, plants have been described as an alternative to the development of new drugs applied to treatment of many diseases such as hypercholesterolemia, ulcers, depurative blood and cancer.

  1. Corispermum intermedium, C. hyssopifolium un C. leptopterum augu sabiedrības, to ietekmējošie faktori un taksonu radniecība

    OpenAIRE

    Peipiņa, Ieva

    2015-01-01

    Latvijas endēmam Corispermum intermedium un svešzemju sugām C. hyssopifolium ar C. leptopterum ir ļoti līdzīga gan morfoloģija, gan ekoloģiskie apstākļi. Literatūrā trūkst datu par Corispermum augu sabiedrībām un to sastopamības noteicošajiem ekoloģiskajiem faktoriem. Maģistra darba mērķis – noteikt jūras piekrastes smiltājos sastopamo kamieļzāļu augu sabiedrību piederību un to ietekmējošos faktorus, kā arī C. intermedium, C. hyssopifolium un C. leptopterum radniecību. Corispermum augu ...

  2. Clima escolar y su relación con la calidad educativa en la I.E. Coronel José Joaquin Inclán 2015

    OpenAIRE

    Sosa Osorio, Jorge Jhonny

    2015-01-01

    El objetivo fue determinar si existe relación entre el clima escolar y la calidad educativa en la Institución Educativa ―José Joaquín Inclán‖, en el distrito del San Juan de Miraflores, periodo 2015. La investigación tuvo un enfoque cuantitativo, de tipo descriptivo correlacional, de diseño no experimental. La población estuvo compuesta por 180 alumnos, de los cuales se tomó una muestra de 123 participantes, obtenidos por muestreo aleatorio, a quienes se les aplicó una encuesta de 12 pregunta...

  3. Estudio de los espacios arquitectónico-educativos en la formación profesional. El caso del I.E.S. Hermenegildo Lanz

    Directory of Open Access Journals (Sweden)

    Antonio RODRÍGUEZ FUENTES

    2016-06-01

    Full Text Available El estudio de los Espacios arquitectónico-educativos de Formación Profesional se presenta en la actualidad como un frente candente de investigación. Una etapa fuertemente condicionada por los lazos que la vinculan, de un lado, con el sistema productivo del país, que tiende a incrementarse por medio de la reciente puesta en práctica de la Formación Profesional Dual o en Alternancia y, de otro, con el resto de las enseñanzas que constituyen la estructura del sistema educativo actual, con una presencia mucho más vertical con la entrada en vigor de la lomce desde las etapas inferiores, por medio de la Formación Profesional básica, hasta las más altas, facilitándose el acceso a la Universidad, tras la finalización del Grado Superior de Formación Profesional y el sistema de convalidaciones previsto entre ambas enseñanzas.Estos argumentos, junto a la singularidad de los contenidos curriculares, con un alto porcentaje de prácticas en talleres, exigen una reconsideración de los espacios escolares de estas enseñanzas, para responder a las demandas del momento. Conocer los requisitos espaciales fijados como necesarios por las disposiciones reglamentarias y el uso que se hace de ellos en los centros docentes, a través del análisis documental y la reflexión individual, del profesorado, equipo directivo, jefes de Departamento y alumnos se erige como un buen motor de arranque del cambio que toda acción de mejora requiere bajo la denominación de innovación educativa o investigación-acción.

  4. SU-G-IeP1-06: Estimating Relative Tissue Density From Quantitative MR Images: A Novel Perspective for MRI-Only Heterogeneity Corrected Dose Calculation

    International Nuclear Information System (INIS)

    Soliman, A; Hashemi, M; Safigholi, H; Tchistiakova, E; Song, W

    2016-01-01

    Purpose: To explore the feasibility of extracting the relative density from quantitative MRI measurements as well as estimate a correlation between the extracted measures and CT Hounsfield units. Methods: MRI has the ability to separate water and fat signals, producing two separate images for each component. By performing appropriate corrections on the separated images, quantitative measurement of water and fat mass density can be estimated. This work aims to test this hypothesis on 1.5T.Peanut oil was used as fat-representative, while agar as water-representative. Gadolinium Chloride III and Sodium Chloride were added to the agar solution to adjust the relaxation times and the medium conductivity, respectively. Peanut oil was added to the agar solution with different percentages: 0%, 3%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. The phantom was scanned on 1.5T GE Optima 450W with the body coil using a multigradient echo sequences. Water/fat separation were performed while correcting for main field (B0) inhomogeneity and T_2* relaxation time. B1+ inhomogeneities were ignored. The phantom was subsequently scanned on a Philips Brilliance CT Big Bore. MR-corrected fat signal from all vials were normalized to 100% fat signal. CT Hounsfield values were then compared to those obtained from the normalized MR-corrected fat values as well as to the phantom for validation. Results: Good agreement were found between CT HU and the MR-extracted fat values (R"2 = 0.98). CT HU also showed excellent agreement with the prepared fat fractions (R"2=0.99). Vials with 70%, 80%, and 90% fat percentages showed inhomogeneous distributions, however their results were included for completion. Conclusion: Quantitative MRI water/fat imaging can be potentially used to extract the relative tissue density. Further in-vivo validation are required.

  5. IE Information Notice No. 85-93: Westinghouse Type DS circuit breakers, potential failure of electric closing feature because of broken spring release latch lever

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    On April 14, 1985, the Westinghouse Nuclear Services Integration Division (NSID) issued Technical Bulletin No. NSID-TB-85-17 advising their customers of a potential malfunction in Westinghouse Type DS Class 1E circuit breakers because of broken spring release latch levers. These electrically operated type DS breakers will not close electrically when the spring release latch lever has been broken off. Twenty-five broken levers have been reported and evaluated. This evaluation shows concentrations of incidents traceable to manufacturing in the following periods of time: early 1975, April 1976, and early 1978. This circuit breaker failure, as discussed, adversely affects the safety function (closing on demand) when the circuit breaker is used in the Engineered Safety Features Systems. However, this failure mode will not affect the safety trip function when it is used in the reactor protection system

  6. SU-G-IeP4-05: Experience with a Practical Approach to the Release of Radioactive Patients from Radiation Safety Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, R; Erwin, W; Fisher, A; Jones, S; Jimenez, S; Wong, F; Jessop, A [UT MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients’ instructions were. Methods: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions. A retrospective analysis of the 218 releases in 2015 that required instructions included all I-131 and Lu-177 treatments. Results: There were 87 male and 131 female patients. They were 45.5±16.5 (8-84) years old, weighed 83.3±21.8 kg and stood 168±10 cm tall with a body mass index of 29.3±6.7 kg/m2. 195 patients received 2.96±2.23 GBq of I-131-NaI for differentiated thyroid carcinoma and eight received 636±231 MBq of I-131-NaI for hyperthyroidism. There were eight administrations of 18.5 GBq of I-131-mIBG and seven administrations of 7.4 GBq of Lu-177-DOTATATE. The dose to the most exposed person was 1.67±1.05 (mode=0.60, median=1.15) mSv. The dose to a fellow traveler was 0.31±0.31 (mode=0.1, median=0.17) mSv. The dose to children and pregnant women was 0.51±0.34 (mode=1.0, median=0.42) mSv. The duration of isolation was 7.7±17.3 (mode=2, median=1.7) hours. The duration of sleeping alone was 60.4±127 (mode=0, median=15.5) hours. The time to delay traveling was 12.2±11 (mode=median=0) hours. The time to completely avoid children and pregnant women was 23.3±26.5 (0–254, mode=median=24) hours followed by limited contact for 20.6±68.1 (0–491, mode=median=0) hours. The time to avoid others (e.g., to wait to return to work) was 12.1±101 (0–1465, mode=median=0) hours. Conclusion: The estimated doses to others were often well below the limits set by regulation, 5 mSv, or prudent practice, 1 mSv. Most patients’ instructions were not hard to comply with.

  7. Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression

    Czech Academy of Sciences Publication Activity Database

    Deeks, M.J.; Cvrčková, F.; Machesky, M. L.; Mikitova, V.; Ketelaar, T.; Žárský, Viktor; Davies, B.; Hussey, P.J.

    2005-01-01

    Roč. 168, č. 3 (2005), s. 529-540 ISSN 0028-646X R&D Projects: GA ČR GA204/02/1461; GA ČR GA204/05/0268 Institutional research plan: CEZ:AV0Z50380511 Keywords : actin * Arabidopsis * cytoskeleton Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.285, year: 2005

  8. Subjetividades emergentes en el manual de convivencia de la IED Nicolás Buenaventura y el Colegio Liceo Homérico

    OpenAIRE

    Gaviria De Lima, Christian Alan; Rojas Cordero, William

    2017-01-01

    Si bien las instituciones educativas ya sean de carácter oficial o privado poseen la autonomía para construir sus Manuales de Convivencia, los mismos deben tener en cuenta las disposiciones que el Ministerio de Educación Nacional refiere al respecto. Se hace evidente la puesta en escena de Manuales de Convivencia que no responden al contexto que viven los establecimientos, sin embargo, si tienen un efecto sobre la configuración del individuo. Los Manuales de Convivencia transportan un saber, ...

  9. ANÁLISIS DE LAS CONCEPCIONES SOBRE EL CONCEPTO DE SISTEMA NERVIOSO EN ESTUDIANTES DE GRADO NOVENO (901 DEL COLEGIO ANTONIO NARIÑO I.E.D

    Directory of Open Access Journals (Sweden)

    Yenny Yadid Olave Chacón

    2015-12-01

    Full Text Available Las concepciones son ideas  u opiniones que se adquieren en la vida cotidiana y el ambiente escolar a través de diferentes experiencias. La primera intervención  didáctica evidencia las concepciones del concepto sistema nervioso, que poseen 6  estudiantes de grado noveno (901, con edades entre 14 y 17 años, de la ciudad de Bogotá D.C, del colegio Antonio Nariño de la jornada tarde. Las concepciones se analizaron bajo el paradigma cualitativo interpretativo; para el análisis se realizaron tres categorías emergentes; que se derivan a partir de los resultados obtenidos en el aula de clase: 1. Funcionalidad, 2. Estructuras Morfológicas y 3. Experiencias, basadas en la información obtenida del cuestionario que se aplicó. Se reconoció que los estudiantes aíslan el sistema nervioso de los demás sistemas, al mismo tiempo le atribuyen funciones motoras y sensitivas. Finalmente se evidencia en sus escritos que tienen errores conceptuales, y contradicen sus explicaciones.

  10. MO-FG-CAMPUS-IeP2-05: Feasibility Demonstration of High-Voltage Clinical CT and Impact On X-Ray Penetration Through Metal Objects

    International Nuclear Information System (INIS)

    Jin, Y; De Man, B; Robinson, V; Gjesteby, L; Wang, G; Verburg, J; Giantsoudi, D; Paganetti, H

    2016-01-01

    Purpose: To demonstrate the possibility and quantify the impact of operating a clinical CT scanner at exceptionally high x-ray tube voltage for better penetration through metal objects and facilitating metal artifact reduction. Methods: We categorize metal objects according to the data corruption severeness (level of distortion and complete photon starvation fraction). To demonstrate feasibility and investigate the impact of high voltage scanning we modified a commercial GE LightSpeed VCT scanner (generator and software) to enable CT scans with x-ray tube voltages as high as 175 kVp. A 20 cm diameter water phantom with two metal rods (10 mm stainless and 25 mm titanium) and a water phantom with realistic metal object (spine cage) were used to evaluate the data corruption and image artifacts in the absence of any algorithm correction. We also performed simulations to confirm our understanding of the transmitted photon levels through metal objects with different size and composition. Results: The reconstructed images at 175 kVp still have significant dark shading artifacts, as expected since no special scatter correction or beam hardening was performed but show substantially lower noise and photon starvation than at lower kVp due to better beam penetration. Analysis of the raw data shows that the photon starved data is reduced from over 4% at 140 kVp to below 0.2% at 175 kVp. The simulations indicate that for clinically relevant titanium and stainless objects a 175 kVp tube voltage effectively avoids photon starvation. Conclusion: The use of exceptionally high tube voltage on a clinical CT system is a practical and effective solution to avoid photon starvation caused by certain metal implants. Sparse and hybrid high-voltage protocols are being considered to maintain low patient dose. This opens the door to algorithmic physics-based corrections rather than treating the data as missing and relying on missing data algorithms. Some of the authors are employees of General Electric

  11. Final work plan: Expedited Site Characterization of the IES Industries, Inc., Site at Marshalltown, Iowa. Ames Expedited Site Characterization Project, Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-04

    The overall goal of the Ames Laboratory Expedited Site Characterization (ESC) project is to evaluate and promote both innovative and state-of-the-practice site characterization and/or monitoring technologies. This will be accomplished by fielding both types of technologies together in the context of an expedited site characterization. The first site will be at a former manufactured gas plant (FMGP) in Marshalltown, Iowa. The project will field three areas of technology: geophysical, analytical, and data fusion. Geophysical technologies are designed to understand the subsurface geology to help predict fate and transport of the target contaminants. Analytical technologies/methods are designed to detect and quantify the target contaminants. Data fusion technology consists of software systems designed to rapidly integrate or fuse all site information into a conceptual site model that then becomes the decision making tool for the site team to plan subsequent sampling activity. Not all of the contaminants present can be located at the action level. Polynuclear aromatic hydrocarbons (PAHs) are the signature organics associated with the coal tar activities that took place at the site. As a result, PAHs were selected as the target compounds. Screening analytical instruments and nonintrusive geophysical techniques will be fielded to qualitatively map the spatial contaminant distribution. Soil gas surveys, immunoassay testing (IMA), innovative optical techniques, and passive organic sorbent sensors will be deployed along with the geophysical methods. Gas chromatography/mass spectrometry (GC/MS) instruments and a cone penetrometer system equipped with a laser-induced fluorescence (LIF) probe will quantitatively map the action level edges of the PAH plume(s). Samples will be taken both by the cone penetrometer test system (CPT) and the Geoprobe {reg_sign} sampler system.

  12. Governança corporativa, responsabilidade social corporativa: a visão de atores de uma instituição de ensino superior – IES federal

    Directory of Open Access Journals (Sweden)

    Maria da Graça Saraiva Nogueira

    2012-12-01

    Full Text Available This study aims to identify the main corporate governance (CG, corporate social responsibility (CSR in an Institution of Higher Education – IHE Federal, through content analysis, interviews with key actors of the organization and his views about this. The methodology used to collect information will be of semi-structured interview, recorded by audio recording and verbatim transcription, with appropriate reading and approval of respondents for the use of its contents in the article presented here. The main results on the CG and the legitimacy, credibility and reliability are present in the institution. Indeed, according to the statements of the respondent we find the integration of management, decision processes that stands for quality and excellence in public education and free. The results relative to CSR found that the IHE study has no formal institutional policies, oriented to the community. Even so, the perception is that the IHE is moving in this direction and believes that institutions do not react proactively in relation to social issues, will be charged by the society itself.

  13. SU-G-IeP4-05: Experience with a Practical Approach to the Release of Radioactive Patients from Radiation Safety Isolation

    International Nuclear Information System (INIS)

    Wendt, R; Erwin, W; Fisher, A; Jones, S; Jimenez, S; Wong, F; Jessop, A

    2016-01-01

    Purpose: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients’ instructions were. Methods: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions. A retrospective analysis of the 218 releases in 2015 that required instructions included all I-131 and Lu-177 treatments. Results: There were 87 male and 131 female patients. They were 45.5±16.5 (8-84) years old, weighed 83.3±21.8 kg and stood 168±10 cm tall with a body mass index of 29.3±6.7 kg/m2. 195 patients received 2.96±2.23 GBq of I-131-NaI for differentiated thyroid carcinoma and eight received 636±231 MBq of I-131-NaI for hyperthyroidism. There were eight administrations of 18.5 GBq of I-131-mIBG and seven administrations of 7.4 GBq of Lu-177-DOTATATE. The dose to the most exposed person was 1.67±1.05 (mode=0.60, median=1.15) mSv. The dose to a fellow traveler was 0.31±0.31 (mode=0.1, median=0.17) mSv. The dose to children and pregnant women was 0.51±0.34 (mode=1.0, median=0.42) mSv. The duration of isolation was 7.7±17.3 (mode=2, median=1.7) hours. The duration of sleeping alone was 60.4±127 (mode=0, median=15.5) hours. The time to delay traveling was 12.2±11 (mode=median=0) hours. The time to completely avoid children and pregnant women was 23.3±26.5 (0–254, mode=median=24) hours followed by limited contact for 20.6±68.1 (0–491, mode=median=0) hours. The time to avoid others (e.g., to wait to return to work) was 12.1±101 (0–1465, mode=median=0) hours. Conclusion: The estimated doses to others were often well below the limits set by regulation, 5 mSv, or prudent practice, 1 mSv. Most patients’ instructions were not hard to comply with.

  14. SU-G-IeP3-02: Characteristics of In-Vivo MOSFET Dosimeters for Diagnostic X-Ray Low-Dose Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Li, S; Ali, S; Harper, K; Liang, Q; Serratore, D [Temple University Hospital, Philadelphia, PA (United States)

    2016-06-15

    Purpose: To correct in-vivo metal-oxide-semiconductor field-effect transistor (MOSFET) dosimeters dependence on X-ray energy, dose and dose rate, and temperature in order to measure doses or exposures on several anatomic points of interest undergoing some routine radiographs. Methods: A mobile MOSFET system (BEST Medical) was carefully calibrated with X-ray at kVp of 70, 80, 100, 120, and 138 kVp, phantom temperatures at 0, 21, and 43 oC, and exposure range from 0.01 to 10 R confirmed with Raysafe and RadCal dosimeters. The MOSFETS were placed on the midline bladder or uterus, left pelvic iliac artery, left abdominal above iliac crest, abdominal midline anterior at inferior margin of stomach, and left pectoral of a large and a small body-size cadavers undergoing AP/PA chest and lumber spine radiographs using manual and automatic exposure control (AEC) with and without lead shielding. MOSTFETs and TLD chips were also placed on the stomach, sigmoid, pubic symphysis, left and right pelvic walls of another cadaver for AP pelvic manual or AEC radiography prior to and after a left hip metal implant. Results: Individual MOSFET detectors had various low-dose limits in ranged from 0.03 to 0.08 R, nonlinear response to X-ray energy, and significant temperature effect of 15%. By accumulating 10 manual exposures and 20 AEC exposures, we achieved dose measured accuracy of 6%. There were up to 8 fold increases for AEC exposure of spine and chest X-ray procedure from no shielding to with shielding. For pelvic radiography, exposure to public symphysis was the highest even higher than that of the skin. After hip implant, AEC pelvic radiograph increase exposure by 30 to 200% consistent with results of TLDs. Conclusion: Dependence of energy, temperature and dose limit were accurately corrected. We have found significant exposure for those clinical pr°ocedures and the study provided evidences for developing new clinical procedures.

  15. MO-FG-CAMPUS-IeP2-05: Feasibility Demonstration of High-Voltage Clinical CT and Impact On X-Ray Penetration Through Metal Objects

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Y; De Man, B [GE Global Research, Niskayuna, NY (United States); Robinson, V [GE, Global Research, Niskayuna, NY (United States); Gjesteby, L [Rensselaer Polytechnic Institute, Troy, NY (United States); Wang, G [Rensselaer Polytechnic Institute Troy, NY (United States); Verburg, J [Massachusetts, General Hospital, Boston, MA (United States); Giantsoudi, D; Paganetti, H [Massachusetts General Hospital, Boston, MA (United States)

    2016-06-15

    Purpose: To demonstrate the possibility and quantify the impact of operating a clinical CT scanner at exceptionally high x-ray tube voltage for better penetration through metal objects and facilitating metal artifact reduction. Methods: We categorize metal objects according to the data corruption severeness (level of distortion and complete photon starvation fraction). To demonstrate feasibility and investigate the impact of high voltage scanning we modified a commercial GE LightSpeed VCT scanner (generator and software) to enable CT scans with x-ray tube voltages as high as 175 kVp. A 20 cm diameter water phantom with two metal rods (10 mm stainless and 25 mm titanium) and a water phantom with realistic metal object (spine cage) were used to evaluate the data corruption and image artifacts in the absence of any algorithm correction. We also performed simulations to confirm our understanding of the transmitted photon levels through metal objects with different size and composition. Results: The reconstructed images at 175 kVp still have significant dark shading artifacts, as expected since no special scatter correction or beam hardening was performed but show substantially lower noise and photon starvation than at lower kVp due to better beam penetration. Analysis of the raw data shows that the photon starved data is reduced from over 4% at 140 kVp to below 0.2% at 175 kVp. The simulations indicate that for clinically relevant titanium and stainless objects a 175 kVp tube voltage effectively avoids photon starvation. Conclusion: The use of exceptionally high tube voltage on a clinical CT system is a practical and effective solution to avoid photon starvation caused by certain metal implants. Sparse and hybrid high-voltage protocols are being considered to maintain low patient dose. This opens the door to algorithmic physics-based corrections rather than treating the data as missing and relying on missing data algorithms. Some of the authors are employees of General Electric.

  16. LUAREA COPILULUI DE LA PĂRINŢI – SANCŢIUNE SAU MĂSURĂ DE PROTECŢIE A MINORULUI?

    Directory of Open Access Journals (Sweden)

    Valentina CEBOTARI

    2016-03-01

    Full Text Available Conform legislaţiei în vigoare, părinţii sunt reprezentanţii legali ai copiilor lor şi sunt obligaţi să acţioneze în intere­sele acestora în raport cu toate persoanele fizice şi juridice, inclusiv cu autorităţile statului. Convenţia ONU privind drepturile copilului din 1989 subliniază, în Preambul, că familia este unitatea fundamentală a societăţii şi mediul natural pentru creşterea şi bunăstarea tuturor membrilor săi, în mod deosebit a copiilor. Studiile în acest domeniu au constatat că pentru dezvoltarea deplină şi armonioasă a personalităţii copilului el are nevoie de dragoste şi înţelegere în familie. Oriunde este posibil el trebuie să crească sub grija şi răspunderea părinţilor săi într-o atmosferă de afecţiune şi securitate morală şi materială, care îi va asigura o dezvoltare fizică normală, spirituală, intelectuală şi socială ca el să devină per­sonalitate. În cazurile în care părinţii nu-şi îndeplinesc obligaţiile sau abuzează de drepturi, organele de stat se implică şi iau măsurile necesare pentru ocrotirea minorilor, lipsindu-i pe părinţi de drepturi sau limitând aceste drepturi. TAKING THE CHILD FROM THE PARENTS: A SANCTION OR A MEASURE OF PROTECTION OF THE A MINOR?According to the legislation, parents are the legal representatives of their children and are obliged to act in their interest in relation with all of human persons and legal persons, including state authorities. UNO convention concerning rights of the child, dating1989, inpreamble highlights that family is a fundamental unit of the society and a natural environment for growing and welfare of all its members, especially of children. Studies in this field established that for full and harmonious development of the child personality he needs love and understanding in the family. Anywhere it is possible he should grow under care and responsibility of his parents, in a fondness, material and moral secured environment that will assure him a normal physical, spiritual, intellectual and social development in the way to become a personality. In case when parents do not execute their obligations or abuse of their rights, state bodies get involved and take the necessary measures for infant protection, depriving them of parental rights or limiting such one.

  17. SU-G-IeP4-12: Performance of In-111 Coincident Gamma-Ray Counting: A Monte Carlo Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Pahlka, R; Kappadath, S; Mawlawi, O [UT MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: The decay of In-111 results in a non-isotropic gamma-ray cascade, which is normally imaged using a gamma camera. Creating images with a gamma camera using coincident gamma-rays from In-111 has not been previously studied. Our objective was to explore the feasibility of imaging this cascade as coincidence events and to determine the optimal timing resolution and source activity using Monte Carlo simulations. Methods: GEANT4 was used to simulate the decay of the In-111 nucleus and to model the gamma camera. Each photon emission was assigned a timestamp, and the time delay and angular separation for the second gamma-ray in the cascade was consistent with the known intermediate state half-life of 85ns. The gamma-rays are transported through a model of a Siemens dual head Symbia “S” gamma camera with a 5/8-inch thick crystal and medium energy collimators. A true coincident event was defined as a single 171keV gamma-ray followed by a single 245keV gamma-ray within a specified time window (or vice versa). Several source activities (ranging from 10uCi to 5mCi) with and without incorporation of background counts were then simulated. Each simulation was analyzed using varying time windows to assess random events. The noise equivalent count rate (NECR) was computed based on the number of true and random counts for each combination of activity and time window. No scatter events were assumed since sources were simulated in air. Results: As expected, increasing the timing window increased the total number of observed coincidences albeit at the expense of true coincidences. A timing window range of 200–500ns maximizes the NECR at clinically-used source activities. The background rate did not significantly alter the maximum NECR. Conclusion: This work suggests coincident measurements of In-111 gamma-ray decay can be performed with commercial gamma cameras at clinically-relevant activities. Work is ongoing to assess useful clinical applications.

  18. NODC Standard Product: Texas-Louisiana Shelf Circulation and Transport Processes Study: Current Meter, Meteorological Buoy, XBT/XSV/XCP/CTD/IES (NODC Accession 9700319)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This package contains current direction/velocity, water temperature, air temperature, salinity, and other data which were collected using current meter, CTD casts,...

  19. IE Information Notice No. 85-47: Potential effect of line-induced vibration on certain Target Rock solenoid-operated valves

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    On November 14, 1984, Arizona Public Services Company provided the NRC with a final report on a 10 CFR 50.55(e) reportable condition relating to qualification testing of certain TR (Target Rock), solenoid-operated valves. Four TR valves, procured by Combustion Engineering (CE) for use at Palo Verde Nuclear Generating Station Unit 3, were tested to the requirements of NUREG-0588, Category 1. Test valves included two 1-inch TR valves, model 77L-001 and two 2-inch TR valves, model 77L-003. The qualification test involved irradiation to 50 megarads, thermal aging at 260 F for 635 hours, mechanical cycling, vibrational aging to represent normal service vibration, seismic testing, and finally, testing in a simulated LOCA environment. The licensee reported that during the qualification testing, a number of anomalies were identified, and the test was discontinued when the test valves failed to function for different reasons during the seismic testing. CE an TR appraised the overall safety significance of the observed test anomalies for the licensee. They considered the failure of the valve to open on demand as a result of solenoid lead shorting caused by line-induced vibrational wear to be a common mode of failure that, in a seismic event, could potentially disable several redundant valves at the same time. This failure of the valve to open on demand is the only observed test anomaly considered to have significant generic safety implications and is the subject of this information notice

  20. ESENŢA ŞI DESTINUL OMULUI – TEMĂ PRIORITARĂ DE REFLECŢIE ÎN FILOSOFIA ROMÂNEASCĂ

    Directory of Open Access Journals (Sweden)

    Svetlana COANDĂ

    2015-12-01

    Full Text Available Articolul dat este consacrat studierii concepţiilor unor mari gânditori români din sec. XIX–XX: Mihai Eminescu, Titu Maiorescu, Constantin Rădulescu-Motru, Constantin Noica, Lucian Blaga, Mircea Eliade, despre esenţa complexă a omului şi destinul său, mentalitatea omului modern, tendinţa de a se salva de teroarea istoriei, despre sistemul de valori care profilează specificul, sensul vieţii şi activităţii omului modern. Este argumentată teza că reflecţiile şi concluziile proeminenţilor noştri înaintaşi despre om ca unitate a sacrului şi profanului, ca fiinţă creatoare de cultură şi valori rămân actuale şi importante pentru procesul instructiv-educaţional contemporan. COMPLEX HUMAN ESSENCE AND DESTINY - THE PRIORITARY REFLECTION THEME IN THE ROMANIAN PHILOSOPHYThe given article is dedicated to studying the conceptions of the great Romanian thinkers from the XIX-XX centuries: Mihai Eminescu, Titu Maiorescu, Constantin Radulescu-Motru, Constantin Noica, Lucian Blaga, Mircea Eliade; concepts about the complex human essence and destiny, the mentality of the modern man, the tendency to be saved from the dread of history, the system of values that profile the specificity and the meaning of life and of the activity of the modern man. The study offers arguments that the reflections and the conclusions of our prominent precursors about man as a unity of the profane and the sacred, as a creator of culture and values remain actual and important to the contemporary instructive-educational process.  

  1. SU-G-IeP1-15: Towards Accurate Cerebral Blood Flow Quantification with Distortion- Corrected Pseudo-Continuous Arterial Spin Labeling

    International Nuclear Information System (INIS)

    Hoff, M; Rane-Levandovsky, S; Andre, J

    2016-01-01

    Purpose: Traditional arterial spin labeling (ASL) acquisitions with echo planar imaging (EPI) readouts suffer from image distortion due to susceptibility effects, compromising ASL’s ability to accurately quantify cerebral blood flow (CBF) and assess disease-specific patterns associated with CBF abnormalities. Phase labeling for additional coordinate encoding (PLACE) can remove image distortion; our goal is to apply PLACE to improve the quantitative accuracy of ASL CBF in humans. Methods: Four subjects were imaged on a 3T Philips Ingenia scanner using a 16-channel receive coil with a 21/21/10cm (frequency/phase/slice direction) field-of-view. An ASL sequence with a pseudo-continuous ASL (pCASL) labeling scheme was employed to acquire thirty dynamics of single-shot EPI data, with control and label datasets for all dynamics, and PLACE gradients applied on odd dynamics. Parameters included a post-labeling delay = 2s, label duration = 1.8s, flip angle = 90°, TR/TE = 5000/23.5ms, and 2.9/2.9/5.0mm (frequency/phase/slice direction) voxel size. “M0” EPI-reference images and T1-weighted spin-echo images with 0.8/1.0/3.3mm (frequency/phase/slice directions) voxel size were also acquired. Complex conjugate image products of pCASL odd and even dynamics were formed, a linear phase ramp applied, and data expanded and smoothed. Data phase was extracted to map control, label, and M0 magnitude image pixels to their undistorted locations, and images were rebinned to original size. All images were corrected for motion artifacts in FSL 5.0. pCASL images were registered to M0 images, and control and label images were subtracted to compute quantitative CBF maps. Results: pCASL image and CBF map distortions were removed by PLACE in all subjects. Corrected images conformed well to the anatomical T1-weighted reference image, and deviations in corrected CBF maps were evident. Conclusion: Eliminating pCASL distortion with PLACE can improve CBF quantification accuracy using minimal pulse sequence modifications and no additional scan time, improving ASL’s clinical applicability.

  2. Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration.

    Directory of Open Access Journals (Sweden)

    Erna Morden

    Full Text Available HIV-exposed uninfected (HEU infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth within the first 28 weeks of life.This is a retrospective cohort based on routine clinical data from two South African PMTCT programmes. Data were collected between 2007 and 2013. Linear regression assessed factors affecting birth weight-for-age z-scores (WAZ while growth (longitudinal WAZ was assessed using mixed effects models.We assessed the growth of 2621 HEU infants (median birth WAZ was -0.65 (IQR -1.46; 0.0 and 51% were male. The feeding modalities practised were as follows: 0.5% exclusive breastfeeding, 7.9% breastfeeding with unknown exclusivity, 0.08% mixed breastfeeding and 89.2% formula feeding. Mothers with CD4 <200 cells/μl delivered infants with a lower birth WAZ (adjusted ß -0.253 [95% CI -0.043; -0.072], p = 0.006 compared to mothers with aCD4 ≥500 cells/μl. Similarly, mothers who did not receive antiretroviral drugs delivered infants with a lower birth WAZ (adjusted ß -0.39 [95% CI -0.67; -0.11], p = 0.007 compared to mothers who received antenatal antiretrovirals. Infants with a birth weight <2 500g (ß 0.070 [95% CI 0.061; 0.078], p <0.0001 experienced faster growth within the first 28 weeks of life compared to infants with a birth weight ≥2 500g. Infants with any breastfeeding exposure experienced slower longitudinal growth compared to formula fed infants (adjusted ß -0.012 [95% CI 0.021; -0.003], p = 0.011.Less severe maternal disease and the use of antiretrovirals positively impacts birth weight in this cohort of South African HEU infants. Formula feeding was common with breastfed infants experiencing marginally slower longitudinal growth.

  3. SU-G-IeP4-08: Initial Investigations of Up-Converting Nanoparticles (UCNP) for 3D Tissue Imaging in Optical-ECT

    International Nuclear Information System (INIS)

    Yoon, S; Dewhirst, M; Oldham, M; Langloss, B; Boss, M; Birer, S

    2016-01-01

    Purpose: Near-IR absorptive up-converting nanoparticles (UCNPs) is a novel contrast for optical-ECT that allows auto-fluorescence-free 3D imaging of labeled cells in a matrix of large (∼1cm 3 ) unsectioned normal tissue. This has the potential to image small metastases or dormant cells that is difficult with down-converting fluorescing dyes due to auto-fluorescence. The feasibility of imaging UCNP in agarose phantoms and a mouse lung is demonstrated, aided by a 3D-printed optical-ECT stage designed to excite UCNP in a mouse lung. Methods: The UCNP, NaYF 4 :Yb/Er (20/2%), studied in this work up-converts 980nm light to visible light peaking sharply at ∼540nm. To characterize the UCNP emission as a function of UCNP concentration, cylindrical 2.5%wt agarose phantoms infused with UCNP at concentrations of 25µg/mL and 50µg/mL were exposed to 1.5W 980nm laser coupled to an optical fiber. The fiber was held stably at 1cm above the stage via a custom 3D-printed stage. An optically cleared lung harvested from a BALBc mice was then injected with 100µL of 1mg/mL UCNP solution ex vivo. Tomographic imaging of the UCNP emission in lung was performed. Results: The laser beam tract is visualized within the agarose phantom. A line profile of UCNP emission at 25µg/mL versus 50µg/mL shows that increasing the UCNP concentration increases emission count. UCNPs injected into a cleared mouse lung disperse throughout the respiratory tract, allowing for visualization and 3D reconstruction. Excitation before and after UCNP injection shows the tissue exhibits no auto-fluorescence at 980nm, allowing clear view of the UCNP without any obscuring features such as conventional down-converting fluorescent tags. Conclusion: We confirm that up-conversion in tissue circumvents completely tissue auto-fluorescence, which allowed background-free 3D reconstruction of the UCNP distribution. We also confirm that raising the UCNP concentration increases emission and that UCNPs are retained in agarose samples during the optical clearing process.

  4. EFSA Panel on Dietetic Products, Nutrition and Allerg ies (NDA) ; Guidance on the scientific requirements for health claims related to appetite ratings, weight management, and blood glucose concentrations

    DEFF Research Database (Denmark)

    Tetens, Inge

    The European Food Safety Authority (EFSA) asked the Panel on Dietetic Products, Nutrition and Allergies (NDA) to draft guidance on scientific requirements for health claims related to appetite ratings, weight management, and blood glucose concentrations. This guidance has been drawn from scientific...... and studies/outcome measures which are acceptable. Rather, it presents examples drawn from evaluations already carried out in order to illustrate the approach of the Panel, as well as some examples which are currently under consideration within ongoing evaluations. A draft of this guidance document, endorsed...

  5. TU-H-CAMPUS-IeP3-01: Simultaneous PET Restoration and PET/CT Co-Segmentation Using a Variational Method

    International Nuclear Information System (INIS)

    Li, L; Tan, S; Lu, W

    2016-01-01

    Purpose: PET images are usually blurred due to the finite spatial resolution, while CT images suffer from low contrast. Segment a tumor from either a single PET or CT image is thus challenging. To make full use of the complementary information between PET and CT, we propose a novel variational method for simultaneous PET image restoration and PET/CT images co-segmentation. Methods: The proposed model was constructed based on the Γ-convergence approximation of Mumford-Shah (MS) segmentation model for PET/CT co-segmentation. Moreover, a PET de-blur process was integrated into the MS model to improve the segmentation accuracy. An interaction edge constraint term over the two modalities were specially designed to share the complementary information. The energy functional was iteratively optimized using an alternate minimization (AM) algorithm. The performance of the proposed method was validated on ten lung cancer cases and five esophageal cancer cases. The ground truth were manually delineated by an experienced radiation oncologist using the complementary visual features of PET and CT. The segmentation accuracy was evaluated by Dice similarity index (DSI) and volume error (VE). Results: The proposed method achieved an expected restoration result for PET image and satisfactory segmentation results for both PET and CT images. For lung cancer dataset, the average DSI (0.72) increased by 0.17 and 0.40 than single PET and CT segmentation. For esophageal cancer dataset, the average DSI (0.85) increased by 0.07 and 0.43 than single PET and CT segmentation. Conclusion: The proposed method took full advantage of the complementary information from PET and CT images. This work was supported in part by the National Cancer Institute Grants R01CA172638. Shan Tan and Laquan Li were supported in part by the National Natural Science Foundation of China, under Grant Nos. 60971112 and 61375018.

  6. SU-G-IeP4-14: Prostate Brachytherapy Activity Measurement and Source Localization by Using a Dual Photon Emission Computed Tomography System: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Lin, C; Lin, H; Chuang, K; Chiang, C [National Tsing Hua University, Hsinchu, Taiwan (China); Tsai, Y [National Taiwan University Hospital, Taipei City, Taiwan (China)

    2016-06-15

    Purpose: To monitor the activity distribution and needle position during and after implantation in operating rooms. Methods: Simulation studies were conducted to assess the feasibility of measurement activity distribution and seed localization using the DuPECT system. The system consists of a LaBr3-based probe and planar detection heads, a collimation system, and a coincidence circuit. The two heads can be manipulated independently. Simplified Yb-169 brachytherapy seeds were used. A water-filled cylindrical phantom with a 40-mm diameter and 40-mm length was used to model a simplified prostate of the Asian man. Two simplified seeds were placed at a radial distance of 10 mm and tangential distance of 10 mm from the center of the phantom. The probe head was arranged perpendicular to the planar head. Results of various imaging durations were analyzed and the accuracy of the seed localization was assessed by calculating the centroid of the seed. Results: The reconstructed images indicate that the DuPECT can measure the activity distribution and locate the seeds dwelt in different positions intraoperatively. The calculated centroid on average turned out to be accurate within the pixel size of 0.5 mm. The two sources were identified when the duration is longer than 15 s. The sensitivity measured in water was merely 0.07 cps/MBq. Conclusion: Preliminary results show that the measurement of the activity distribution and seed localization are feasible using the DuPECT system intraoperatively. It indicates the DuPECT system has potential to be an approach for dose-distribution-validation. The efficacy of acvtivity distribution measurement and source localization using the DuPECT system will evaluated in more realistic phantom studies (e.g., various attenuation materials and greater number of seeds) in the future investigation.

  7. PRIVERZhENNOST' PROFILAKTIKE OSTEOPOROZA I VLIYaYuShchIE NA NEE FAKTORY U ZhITEL'NITs MOSKOVSKOY OBLASTI

    Directory of Open Access Journals (Sweden)

    L A MARChENKOVA

    2014-12-01

    Full Text Available Despite high prevalence and severity of complications, osteoporosis (OP in Russia is still not recognized as a socially significant disease and there are no common standards for prevention of OP and associated fractures. The aim of the study was to investigate the adherence of healthy females to prevention measures of OP and the affecting it factors to develop the principles governing the preventive strategy of OP. Methods. The study is performed in Moscow Region (MR in a form of a questionnaire survey in the population of adult healthy women aged >20 years. The data are obtained using "Questionnaires on osteoporosis prevention" and "The test of knowledge in the field of osteoporosis" developed in Clinical Research Institution of Moscow Region named after M.F. Vladimirsky. Study comprised 1712 female aged from 20 till 87 years (median 55,0 years [45,0; 44,0] living in 16 districts and 11 cities of MR. Taking into account the quality of the filling of questionnaires, data provided by 1631 women were included in the statistical analysis. Results. It is established that 31% of female inhabitants of MR are engaged in OP prevention, using for this purpose mainly calcium-containing drugs (64,3% and increased consumption of calcium in food (59,8%. 93% of these women get preventive therapy at their own expense, spending on them on the average 200 rub a month, and preventive medication has appeared more saving than non-pharmacological preventive measures. Socially active working women at the age of 50-69 years are motivated on prevention of OP better than others. Level of the OP awareness and undertaking densitometry screening also directly influence adherence to OP prevention.

  8. SU-G-IeP4-09: Method of Human Eye Aberration Measurement Using Plenoptic Camera Over Large Field of View

    International Nuclear Information System (INIS)

    Lv, Yang; Wang, Ruixing; Ma, Haotong; Zhang, Xuanzhe; Ning, Yu; Xu, Xiaojun

    2016-01-01

    Purpose: The measurement based on Shack-Hartmann wave-front sensor(WFS), obtaining both the high and low order wave-front aberrations simultaneously and accurately, has been applied in the detection of human eyes aberration in recent years. However, Its application is limited by the small field of view (FOV), slight eye movement leads the optical bacon image exceeds the lenslet array which result in uncertain detection error. To overcome difficulties of precise eye location, the capacity of detecting eye wave-front aberration over FOV much larger than simply a single conjugate Hartmann WFS accurately and simultaneously is demanded. Methods: Plenoptic camera’s lenslet array subdivides the aperture light-field in spatial frequency domain, capture the 4-D light-field information. Data recorded by plenoptic cameras can be used to extract the wave-front phases associated to the eyes aberration. The corresponding theoretical model and simulation system is built up in this article to discuss wave-front measurement performance when utilizing plenoptic camera as wave-front sensor. Results: The simulation results indicate that the plenoptic wave-front method can obtain both the high and low order eyes wave-front aberration with the same accuracy as conventional system in single visual angle detectionand over FOV much larger than simply a single conjugate Hartmann systems. Meanwhile, simulation results show that detection of eye aberrations wave-front in different visual angle can be achieved effectively and simultaneously by plenoptic method, by both point and extended optical beacon from the eye. Conclusion: Plenoptic wave-front method possesses the feasibility in eye aberrations wave-front detection. With larger FOV, the method can effectively reduce the detection error brought by imprecise eye location and simplify the eye aberrations wave-front detection system comparing with which based on Shack-Hartmann WFS. Unique advantage of the plenoptic method lies in obtaining wave-front in different visual angle simultaneously, which provides an approach in building up 3-D model of eye refractor tomographically. Funded by the key Laboratory of High Power Laser and Physics, CAS Research Project of National University of Defense Technology No. JC13-07-01; National Natural Science Foundation of China No. 61205144

  9. ECHIPELE DE LUCRU AUTOCOORDONATE O SOLUŢIE MODERNĂ DE ORGANIZARE A UNITĂŢILOR OPERATIVE DIN INDUSTRIA OSPITALITĂŢII

    Directory of Open Access Journals (Sweden)

    Radu EMILIAN

    2006-06-01

    Full Text Available The industry of hospitality is one of the most valuable components of the third sector; in this context, already known, the solution of the companies whatever their category classification and type of establishment is to offer services that correspond to the promises made - therefore services that have a cost-price rapport in favor of the client. In the third sector and in hospitality business in particular, the human resources play a significant role in satisfying the clients and in offering a quality service that have been promised by the category of the hotel. The abilities of managers and their collaborators, the approach to utilization and organization of human resources can provide enterprises with important competitive advantages. In order to achieve this aim, the firms can experiment different ways to manage human resources. In this paper we will emphasis aspects of organizing the activity. We will underline the most important elements of an organization restructuring in hospitality industry: creation of auto coordinated working teams and design of horizontal organizational structures witch promote the interaction of employees from several departments.

  10. Variaţii privind trimiterile preliminare la Curtea de Justiţie provenite din statele membre – Sunt factorii structurali (parte a) explicaţiei?

    DEFF Research Database (Denmark)

    Broberg, Morten; Fenger, Niels

    2013-01-01

    of EU law. When considering the number of references from different Member States, it will become immediately apparent that there are considerable variations. This article examines to what extent these variations may be explained by three structural factors, namely (1) population size, (2) willingness...... to litigate, and (3) Member State compliance with EU law. It is concluded that some - but not all - of the variations in number of references from Member State judiciaries may be attributed to structural factors rather than being merely a reflection of different Member State courts’ willingness to make use...

  11. SU-G-IeP3-12: Preliminary Report On the Experience of Patient Radiation Dose Monitoring and Tracking Systems; PEMNET, Radimetrics and DoseWatch

    International Nuclear Information System (INIS)

    Lin, P; Corwin, F; Ghita, M

    2016-01-01

    Purpose: Three patient radiation dose monitoring and tracking (PRDMT) systems have been in operation at this institution for the past 6 months. There are useful information that should be disseminated to those who are considering installation of PRDMT programs. In addition, there are “problems” uncovered in the process of estimating fluoroscopic “peak” skin dose (PSD), especially, for those patients who received interventional angiographic studies and in conjunction with surgical procedures. Methods: Upon exporting the PRDMT data to Microsoft Excel program, the peak skin dose can be estimated by applying various correction factors including; attenuation due to the tabletop and examination mattress, table height, tabletop translation, backscatter, etc. A procedure was established to screen and divide the PRDMT reported radiation dose and estimated PSD to three different levels of threshold to assess the potential skin injuries, to assist patient follow-up, risk management and provide radiation dosimetry information in case of “Sentinel Event”. Results: The Radiation Dose Structured Report (RDSR) was found to be the prerequisite for the PRDMT systems to work seamlessly. And, the geometrical parameters (gantry and table orientation) displayed by the equipment are not necessarily implemented in the “patient centric” manner which could result in a large error in the PSD estimation. Since, the PRDMT systems obtain their pertinent data from the DICOM tags including the polarity (+ and − signs), the geometrical parameters need to be verified. Conclusion: PRDMT systems provide a more accurate PSD estimation than previously possible as the air-kerma-area dose meter become widely implemented. However, care should be exercised to correctly apply the geometrical parameters in estimating the patient dose. In addition, further refinement is necessary for these software programs to account for all geometrical parameters such as the tabletop translation in the z-direction in particular.

  12. IE Information Notice No. 85-64: BBC Brown Boveri low-voltage K-line circuit breakers, with deficient overcurrent trip devices models OD-4 and 5

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    On May 13, 1985, BBC Brown Boveri Inc. (BBC) made a 10 CFR Part 21 report to the NRC concerning a deficiency in the Models OD-4 and OD-5 overcurrent trip devices installed on K-line circuit breakers. The affected breakers were manufactured by BBC from October 1983 to March 1985 and may have incorrect short time delay band levers (links) installed in electromechanical overcurrent trip device models OD-4 and OD-5. The incorrect link could limit the travel of the short time armature and cause the short time element to be inoperative in the maximum (MAX) band. The May 13, 1985, report recommended that all K-line circuit breakers with the OD-4 and OD-5 overcurrent trip devices and any spare OD-4 and OD-5 overcurrent trip devices that were manufactured between October 1983 and March 1985, be inspected for an incorrect short time delay band link. Licensees known by BBC to have purchased K-line breakers or spare OD-4 or OD-5 overcurrent trip devices were notified of the possible defect and instructions provided for their inspection. Enclosed is a list of utilities and related facilities that were notified by BBC. However, BBC advised the NRC that there is a possibility that other utilities could be using K-line circuit breakers with the suspect OD-4 and OD-5 overcurrent trip devices. Therefore, all licensees are being notified of this possible defect

  13. IE Information Notice No. 85-18, Supplement 1: Failures of undervoltage output circuit boards in the Westinghouse-designed solid state protection system

    International Nuclear Information System (INIS)

    Rossi, C.E.

    1992-01-01

    The US Nuclear Regulatory Commission (NRC) is issuing this information notice supplement to alert addressees to continuing problems associated with the undervoltage (UV) output circuit boards (driver cards) in the solid state protection system (SSPS) designed by the Westinghouse Electric Corporation (Westinghouse). On June 3, 1991, the Shearon Harris Nuclear Power Plant, Unit 1, (Harris) experienced an automatic reactor trip from 100 percent power on a spurious low reactor coolant system loop flow signal. The signal was generated as a result of a surveillance test being performed on one of three loop flow transmitters. The licensee attributed the spurious signal to both procedural inadequacies and personnel error. A control room operator verified that all control rods had fully inserted following the trip signal and that reactor power was properly decreasing. However, about 22 seconds after the automatic trip signal was generated, operators discovered that the ''A'' reactor trip breaker (RTB) had not opened. The RTB was manually opened using the reactor trip switch on the main control board. Subsequent analyses are discussed

  14. A first experiment on the scavenging of materials by rainfall using a large artificial climate experiment chamber at ACEF in IES

    International Nuclear Information System (INIS)

    Kawabata, Hitoshi; Hasegawa, Hidenao; Akata, Naofumi; Chikuchi, Yuki; Kondo, Kunio; Inaba, Jiro

    2004-01-01

    Radionuclides in the atmosphere are removed to rough surfaces on the earth through wet or dry removal. According to our past results, the wet deposition flux of sea-salt particles is larger than the dry deposition flux in Rokkasho, Aomori. Therefore, to clarify the mechanism of wet removal of aerosol particles, a laboratory experiment using a large artificial climate experiment chamber at the Artificial Climate Experiment Facility (ACEF) in the Institute for Environmental Sciences was started. We conducted a preliminary experiment on the scavenging of aerosol particles by raindrops. The scavenging coefficient for NaCl particles was larger than that for test powder (JIS Z 8901 No. 11 Kanto loam). The scavenging coefficients for NaCl particles and test powder increased exponentially with the increase of precipitation intensity. (author)

  15. TU-H-CAMPUS-IeP1-01: Bias and Computational Efficiency of Variance Reduction Methods for the Monte Carlo Simulation of Imaging Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, D; Badano, A [Division of Imaging, Diagnostics and Software Reliability, OSEL/CDRH, Food & Drug Administration, MD (United States); Sempau, J [Technical University of Catalonia, Barcelona (Spain)

    2016-06-15

    Purpose: Variance reduction techniques (VRTs) are employed in Monte Carlo simulations to obtain estimates with reduced statistical uncertainty for a given simulation time. In this work, we study the bias and efficiency of a VRT for estimating the response of imaging detectors. Methods: We implemented Directed Sampling (DS), preferentially directing a fraction of emitted optical photons directly towards the detector by altering the isotropic model. The weight of each optical photon is appropriately modified to maintain simulation estimates unbiased. We use a Monte Carlo tool called fastDETECT2 (part of the hybridMANTIS open-source package) for optical transport, modified for VRT. The weight of each photon is calculated as the ratio of original probability (no VRT) and the new probability for a particular direction. For our analysis of bias and efficiency, we use pulse height spectra, point response functions, and Swank factors. We obtain results for a variety of cases including analog (no VRT, isotropic distribution), and DS with 0.2 and 0.8 optical photons directed towards the sensor plane. We used 10,000, 25-keV primaries. Results: The Swank factor for all cases in our simplified model converged fast (within the first 100 primaries) to a stable value of 0.9. The root mean square error per pixel for DS VRT for the point response function between analog and VRT cases was approximately 5e-4. Conclusion: Our preliminary results suggest that DS VRT does not affect the estimate of the mean for the Swank factor. Our findings indicate that it may be possible to design VRTs for imaging detector simulations to increase computational efficiency without introducing bias.

  16. CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli

    Science.gov (United States)

    Díez-Villaseñor, César; Guzmán, Noemí M.; Almendros, Cristóbal; García-Martínez, Jesús; Mojica, Francisco J.M.

    2013-01-01

    Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guide CRISPR-associated (Cas) proteins to degrade (interference) protospacers flanked by an adjacent motif in extrachomosomal DNA. During acquisition, selection of spacer-precursors adjoining the protospacer motif and proper orientation of the integrated fragment with respect to the leader (sequence leading transcription of the flanking CRISPR array) grant efficient interference by at least some CRISPR-Cas systems. This adaptive stage of the CRISPR action is poorly characterized, mainly due to the lack of appropriate genetic strategies to address its study and, at least in Escherichia coli, the need of Cas overproduction for insertion detection. In this work, we describe the development and application in Escherichia coli strains of an interference-independent assay based on engineered selectable CRISPR-spacer integration reporter plasmids. By using this tool without the constraint of interference or cas overexpression, we confirmed fundamental aspects of this process such as the critical requirement of Cas1 and Cas2 and the identity of the CTT protospacer motif for the E. coli K12 system. In addition, we defined the CWT motif for a non-K12 CRISPR-Cas variant, and obtained data supporting the implication of the leader in spacer orientation, the preferred acquisition from plasmids harboring cas genes and the occurrence of a sequential cleavage at the insertion site by a ruler mechanism. PMID:23445770

  17. Washout ratio of NaCl particles by raindrops, snowflakes and fog particles obtained using the large artificial climate experiment chamber at ACEF in IES

    International Nuclear Information System (INIS)

    Kawabata, Hitoshi; Kondo, Kunio; Hasegawa, Hidenao; Akata, Naofumi; Chikuchi, Yuki; Hisamatsu, Shun'ichi; Inaba, Jiro; Komagata, Yuuetsu

    2007-01-01

    Scavenging of NaCl particles by rainfall, snowfall and fog was examined in a large artificial climate experiment chamber in which the meteorological elements were controlled. The scavenging coefficient of Na by rainfall and snowfall were obtained using Na concentrations in air and precipitation. The washout ratio of Na by fog was also measured using Na concentrations in air and fog water. The scavenging coefficients by snowfall were found to be larger than those by rainfall, and showed that the removal efficiency of the former was higher than that of the latter. The coefficients by both rainfall and snowfall increased linearly with precipitation intensity. When the average diameters of fog droplets were the same, the washout ratio of Na by fog increased with fog liquid water content. On the other hand, when liquid water contents were the same, the washout ratio decreased with increasing average diameter of fog droplets. The washout ratio of Na by fog exponentially increased with the total surface area of fog droplets. (author)

  18. SU-G-IeP1-06: Estimating Relative Tissue Density From Quantitative MR Images: A Novel Perspective for MRI-Only Heterogeneity Corrected Dose Calculation

    Energy Technology Data Exchange (ETDEWEB)

    Soliman, A; Hashemi, M; Safigholi, H [Sunnybrook Research Institute, Toronto, ON (Canada); Sunnybrook Health Sciences Centre, Toronto, ON (Canada); Tchistiakova, E [Sunnybrook Health Sciences Centre, Toronto, ON (Canada); University of Toronto, Toronto, ON (Canada); Song, W [Sunnybrook Research Institute, Toronto, ON (Canada); Sunnybrook Health Sciences Centre, Toronto, ON (Canada); University of Toronto, Toronto, ON (Canada)

    2016-06-15

    Purpose: To explore the feasibility of extracting the relative density from quantitative MRI measurements as well as estimate a correlation between the extracted measures and CT Hounsfield units. Methods: MRI has the ability to separate water and fat signals, producing two separate images for each component. By performing appropriate corrections on the separated images, quantitative measurement of water and fat mass density can be estimated. This work aims to test this hypothesis on 1.5T.Peanut oil was used as fat-representative, while agar as water-representative. Gadolinium Chloride III and Sodium Chloride were added to the agar solution to adjust the relaxation times and the medium conductivity, respectively. Peanut oil was added to the agar solution with different percentages: 0%, 3%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. The phantom was scanned on 1.5T GE Optima 450W with the body coil using a multigradient echo sequences. Water/fat separation were performed while correcting for main field (B0) inhomogeneity and T{sub 2}* relaxation time. B1+ inhomogeneities were ignored. The phantom was subsequently scanned on a Philips Brilliance CT Big Bore. MR-corrected fat signal from all vials were normalized to 100% fat signal. CT Hounsfield values were then compared to those obtained from the normalized MR-corrected fat values as well as to the phantom for validation. Results: Good agreement were found between CT HU and the MR-extracted fat values (R{sup 2} = 0.98). CT HU also showed excellent agreement with the prepared fat fractions (R{sup 2}=0.99). Vials with 70%, 80%, and 90% fat percentages showed inhomogeneous distributions, however their results were included for completion. Conclusion: Quantitative MRI water/fat imaging can be potentially used to extract the relative tissue density. Further in-vivo validation are required.

  19. SU-G-IeP4-04: DD-Neutron Source Collimation for Neutron Stimulated Emission Computed Tomography: A Monte Carlo Simulation Study

    International Nuclear Information System (INIS)

    Fong, G; Kapadia, A

    2016-01-01

    Purpose: To optimize collimation and shielding for a deuterium-deuterium (DD) neutron generator for an inexpensive and compact clinical neutron imaging system. The envisioned application is cancer diagnosis through Neutron Stimulated Emission Computed Tomography (NSECT). Methods: Collimator designs were tested with an isotropic 2.5 MeV neutron source through GEANT4 simulations. The collimator is a 52×52×52 cm"3 polyethylene block coupled with a 1 cm lead sheet in sequence. Composite opening was modeled into the collimator to permit passage of neutrons. The opening varied in shape (cylindrical vs. tapered), size (1–5 cm source-side and target-side openings) and aperture placements (13–39 cm from source-side). Spatial and energy distribution of neutrons and gammas were tracked from each collimator design. Parameters analyzed were primary beam width (FWHM), divergence, and efficiency (percent transmission) for different configurations of the collimator. Select resultant outputs were then used for simulated NSECT imaging of a virtual breast phantom containing a 2.5 cm diameter tumor to assess the effect of the collimator on spatial resolution, noise, and scan time. Finally, composite shielding enclosure made of polyethylene and lead was designed and evaluated to block 99.99% of neutron and gamma radiation generated in the system. Results: Analysis of primary beam indicated the beam-width is linear to the aperture size. Increasing source-side opening allowed at least 20% more neutron throughput for all designs relative to the cylindrical openings. Maximum throughput for all designs was 364% relative to cylindrical openings. Conclusion: The work indicates potential for collimating and shielding a DD neutron generator for use in a clinical NSECT system. The proposed collimator designs produced a well-defined collimated neutron beam that can be used to image samples of interest with millimeter resolution. Balance in output efficiency, noise reduction, and scan time should be considered to determine the optimal design for specific NSECT applications.

  20. Preferencias musicales y su influencia en el aula de música en estudiantes del IES Leonardo da Vinci de Majadahonda

    OpenAIRE

    Rojas Romero de Castilla, María Dolores

    2014-01-01

    En el presente trabajo de investigación se va a tratar la importancia que tiene la música en la vida de los adolescentes, y los estilos musicales que más cercanos están a ellos. La música está muy presente en la vida de los adolescentes ya que es un medio de expresión, identificación, relación con los demás, comunicación, etc. Por esta razón, resulta interesante reflexionar sobre la presencia en el aula entre la música popular, la tradicional y la clásica o culta, que se suele estudiar en la ...