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Sample records for biographical details sir

  1. The Biographical Encyclopedia of Astronomers

    CERN Document Server

    Hockey, Thomas; Williams, Thomas R; Bracher, Katherine; Jarrell, Richard A; Marché, Jordan D; Ragep, F. Jamil; Palmeri, JoAnn; Bolt, Marvin

    2007-01-01

    The Biographical Encyclopedia of Astronomers is a unique and valuable resource for historians and astronomers alike. The two volumes include approximately 1550 biographical sketches on astronomers from antiquity to modern times. It is the collective work of about 400 authors edited by an editorial board of 9 historians and astronomers, and provides additional details on the nature of an entry and some summary statistics on the content of entries. This new reference provides biographical information on astronomers and cosmologists by utilizing contemporary historical scholarship. Individual entries vary from 100 to 1500 words, including the likes of the superluminaries such as Newton and Einstein, as well as lesser-known astronomers like Galileo's acolyte, Mario Guiducci. A comprehensive contributor index helps researchers to identify the authors of important scientific topics and treatises.

  2. Biographical encyclopedia of astronomers

    CERN Document Server

    Trimble, Virginia; Williams, Thomas; Bracher, Katherine; Jarrell, Richard; Marché, Jordan; Palmeri, JoAnn; Green, Daniel

    2014-01-01

    The Biographical Encyclopedia of Astronomers is a unique and valuable resource for historians and astronomers alike. It includes approx. 1850 biographical sketches on astronomers from antiquity to modern times. It is the collective work of 430 authors edited by an editorial board of 8 historians and astronomers. This reference provides biographical information on astronomers and cosmologists by utilizing contemporary historical scholarship. The fully corrected and updated second edition adds approximately 300 biographical sketches. Based on ongoing research and feedback from the community, the new entries will fill gaps and provide expansions. In addition, greater emphasis on Russo phone astronomers and radio astronomers is given. Individual entries vary from 100 to 1500 words, including the likes of the super luminaries such as Newton and Einstein, as well as lesser-known astronomers like Galileo's acolyte, Mario Guiducci.

  3. Obituaries and biographical notes

    NARCIS (Netherlands)

    Vink, W.

    1983-01-01

    Beccari, Odoardo (1843-1920) R.E.G. Pichi Sermolli & C.G.G.J. van Steenis, Dedication, Fl. Males. I, 9 (1983) (6)-(44), 3 portr. Full biographical account of this versatile explorer in Sarawak, West New Guinea and Central Sumatra, and palm taxonomist, prolific writer in Italian whose work at

  4. Open and Closed Biographical Politicization

    Directory of Open Access Journals (Sweden)

    Dirk Michel-Schertges

    2011-05-01

    Full Text Available The article deals with political socialization with particular consideration of open and closed processes of biographical politicization, i.e. biographical alienation. Based on narrative-biographical and theme-oriented interviews with two survivors of the Holocaust, processes of consciousness are analyzed. Henri LEFEBVRE refers in the chapter "the lived and the living" in his third volume of the "Critique of Everyday Live" (1975 to the complexity of processes of consciousness. According to LEFEBVRE there is a dialectic between the "lived" and the "living", thus the "lived" cannot be characterized only as past actions but as past experiences, constituting dialectically the present—the "living." For LEFEBVRE there is an inescapable conflict between past experiences and present life, i.e. the past could be seen as a constituting part of the conditions of individual (and societal present consciousness. Following this line of thought, one could state that to analyze former biographical (extraordinary experiences, i.e. "the lived," is crucial to better understanding of the constitutional conditions of processes of political socialization. Thus former extraordinary biographical experiences might have an essential impact on political socialization and, therefore, on political attitudes. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1102225

  5. Albert Einstein: A Biographical Sketch

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 4. Albert Einstein: A Biographical Sketch. Maja Winteler-Einstein. Reflections Volume 5 Issue 4 April 2000 pp 111-120. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/005/04/0111-0120 ...

  6. Albert Einstein: A Biographical Sketch

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 4. Albert Einstein: A Biographical Sketch. Maja Winteler-Einstein. Reflections Volume 5 Issue 4 April 2000 pp 111-120. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/005/04/0111-0120 ...

  7. [SIRS in surgical stress].

    Science.gov (United States)

    Sato, N; Endo, S; Ikeda, K; Koeda, K; Kimura, Y; Iwaya, T; Ishida, K; Maesawa, C; Iijima, S; Uesugi, N; Saito, K

    2000-06-01

    It has been suggested that SIRS are triggered by superfluous pro-inflammatory cytokine production, and that organ injury is caused by uncontrolled inflammatory responses. However, the results of clinical studies, on the usefulness of specific cytokine antagonists and anti-TNF antibodies for the treatment of septic shock, have been unsatisfactory. The reason for this might have been that when uncontrolled inflammatory reactions progressed locally, anti-inflammatory reactions were elevated in the circulated blood by way of CARS, thus the timing of administration and pharmacokinetics did not match clinical course. Recent research has shown that SIRS is always accompanied by CARS, and since it seems to do the amplitude of SIRS and CARS to each other so that there may be a deep valley, if there is a high mountain. We introduce the recent knowledge which indicates that SIRS is a preliminary alert for not only organ dysfunction but also immunosuppression after severe injury or major surgery.

  8. Sir isaac newton

    CERN Document Server

    Gordon, Fernando

    2016-01-01

    Scientists can change the world! Sir Isaac Newton's experiments helped us understand mass. This title introduces budding scientists and engineers to Sir Isaac Newton whose discoveries changed the course of science. Photos and illustrations bring the stories of this great mind to life, and a quiz lets readers test their newfound knowledge. Aligned to Common Core Standards and correlated to state standards. Applied to STEM Concepts of Learning Principles. Super Sandcastle is an imprint of Abdo Publishing, a division of ABDO.

  9. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    He married May Constance Carter in 1908 and they had a son and a daughter. Sir. Gilbert Walker died at Cousdon, Surrey on 4 November 1958. In an obituary written in. 1959, P A Sheppard argued that Walker's statistical method for forecasting Indian monsoon was not a great success. This view was prevalent till the ...

  10. Sir M Visvesvaraya

    Indian Academy of Sciences (India)

    Page 1. CPMG/KA/BGE-340/2002. Licenced to post WPP(E) NO.6. Resonance - May 2002. Sir M Visvesvaraya. (1860 - 1961). Registered with Registrar of Newspapers in India vide Regn. No. 66273/96. ISSN 0971-8044.

  11. Influenza SIRS with Minimal Pneumonitis.

    Science.gov (United States)

    Erramilli, Shruti; Mannam, Praveen; Manthous, Constantine A

    2016-01-01

    Although systemic inflammatory response syndrome (SIRS) is a known complication of severe influenza pneumonia, it has been reported very rarely in patients with minimal parenchymal lung disease. We here report a case of severe SIRS, anasarca, and marked vascular phenomena with minimal or no pneumonitis. This case highlights that viruses, including influenza, may cause vascular dysregulation causing SIRS, even without substantial visceral organ involvement.

  12. Influenza SIRS with Minimal Pneumonitis

    OpenAIRE

    Erramilli, Shruti; Mannam, Praveen; Manthous, Constantine A.

    2016-01-01

    Although systemic inflammatory response syndrome (SIRS) is a known complication of severe influenza pneumonia, it has been reported very rarely in patients with minimal parenchymal lung disease. We here report a case of severe SIRS, anasarca, and marked vascular phenomena with minimal or no pneumonitis. This case highlights that viruses, including influenza, may cause vascular dysregulation causing SIRS, even without substantial visceral organ involvement.

  13. Sir John Meurig Thomas.

    Science.gov (United States)

    Thomas, John Meurig

    2013-10-11

    "My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Sir Harold Jeffreys

    Science.gov (United States)

    Spall, H.

    1980-01-01

    Sir Harold Jeffreys is a world authority in theoretical geophyiscs. hew as born in Northumbria (northeast of England) and educated at Armstrong College (now the University of Newcastle-upon-Tyne) and Cambridge University. He is now a Senior Fellow of St.John's College, Cambridge. He has published over 300 scientific papers and is the author of 7 books, including Theory of Probability and Mathematical Physics (with his wife, Lady Bertha Swirles Jeffreys). Sir Harold has made innumerable theoretical contributions to seismology. Many of these are documented in his book The Earth, which has been published in six editions. His papers have recently been collated by Gordon and Breach (Publishers) into six volumes, Collected Papers on Sir Harold Jeffreys on Geophyiscs and other Sciences. Some idea of the breadth of this research can be seen from the individual volume titles: "Theoretical and Observational Seismology," "Observational Seismology," "Gravity," "Dissipation of Energy and Thermal History," "Astronomy and Geophysics," and "Matematics, Probability and Miscellaneious Other Sciences." 

  15. Biographical approach to human resource management

    Directory of Open Access Journals (Sweden)

    Ratković-Njegovan Biljana

    2015-01-01

    Full Text Available The paper discusses the importance of biographical approach to managing human resources, which is especially important in the first, anticipatory stage of organizational socialization, in which interview for the job is performed. Biographical principle is based on a broader and more complex approach to the candidate, which enables him to present his working career, personal qualities, professional knowledge and skills, social skills, interests and aspirations. Biographical approach allows an individual who has applied for a certain job to reflect, identify and present their work and life path in their own way.. The organization, in turn, through the biographical method receives valid information to predict the future behavior of candidates and their performance.

  16. Eight Physicists and Astronomers: Biographical Portraits

    OpenAIRE

    Kragh, Helge

    2012-01-01

    This essay provides concise biographical information about eight physicists, astronomers, astrophysicists, and cosmologists from the twentieth century. The portrayed scientists are Hermann Bondi (1919-2005), Charles L. Critchfield (1910-1994), Arthur E. Haas (1884-1941), Chushiro Hayashi (1920-2010, Gustave Le Bon (1841-1931), Wilhelm Lenz (1888-1957), Franz Selety (1893-1933?), and S. Elis Str\\"omgren (1870-1947). Because the entries were written for a biographical dictionary of astronomers,...

  17. Influenza SIRS with minimal pneumonitis

    Directory of Open Access Journals (Sweden)

    Shruti Erramilli

    2016-08-01

    Full Text Available While systemic inflammatory response syndrome (SIRS, is a known complication of severe influenza pneumonia, it has been reported very rarely in patients with minimal parenchymal lung disease. We here report a case of severe SIRS, anasarca and marked vascular phenomena with minimal or no pneumonitis. This case highlights that viruses, including influenza, may cause vascular dysregulation causing SIRS, even without substantial visceral organ involvement.

  18. Whither Sir William?

    Directory of Open Access Journals (Sweden)

    Stephen J. Greenberg, MSLS, PhD

    2017-04-01

    Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

  19. Sir Isaac Newton

    Directory of Open Access Journals (Sweden)

    E. A. Venter

    1964-03-01

    Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

  20. Turnover, Biographical Data, and Fair Employment Practice

    Science.gov (United States)

    Cascio, Wayne F.

    1976-01-01

    Describes a study that tested the validity of using job applicants' biographical data to predict employee turnover among minority and nonminority female clerical personnel. Findings showed that even after satisfying legal requirements for using such information, turnover can be predicted quite accurately. For availability see EA 507 670.…

  1. Workplace, Biographical and Motivation Factors Affecting ...

    African Journals Online (AJOL)

    This paper presents the findings of a survey on how workplace, biographical and motivational factors affect the organisational commitment of records officers in federal universities in Nigeria. Single stage random sampling, with equal allocation method, was used to administer questionnaire on 300 sampled participants from ...

  2. George Gamow–A Biographical Sketch

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 7. George Gamow – A Biographical Sketch. Biman Nath. Article-in-a-Box Volume 9 Issue 7 July 2004 pp 3-5. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/009/07/0003-0005. Author Affiliations.

  3. Music as a Component of Biographic Text

    Directory of Open Access Journals (Sweden)

    Svitlana Macenka

    2014-11-01

    Full Text Available The role of music in the biography of a musician is analyzed. The focus is on the life of famous composers interpretation via their work and the role of music in structuring, aestheticization, additional semantization of biography. It is indicated that the artist stands out in the context of his time as the center of productive gravity, thus a musician’s biography demonstrates communication of the life and creative ways, distinguishing its major milestones and at the same time emphasizing the individual changes of the artist and those his innovations that defined the image of the era. It goes about the semantization of music by an author-biographer, the desire to articulate the principles of an individual artist (also by reference to the listening to musical works, comprehended as his musical text, with its help. For example, the genre of musician biography is viewed as based on the corresponding biographies of W. A. Mozart, Ludwig van Beethoven and Richard Strauss. It is noted that W. A. Mozart is considered a catalyst for musical biographical writing, for certain events of his life were such that he started to be generally recognized as the prototype of the artist. Biographers of both Mozart and Beethoven are convinced of the efficiency of the biographical method in relation to musical analysis. Richard Strauss’s musical-biographical text is also structured according to the logic of musical thinking. A tendency towards correlation between life and work inherent in the biographies of musicians is also peculiar to the novel which tends to music.

  4. Author Details

    African Journals Online (AJOL)

    Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text ... Abstract · Vol 17 (2010) - Articles Investigating The Travelling Wave Solution For an SIR Endemic Disease Model With No Disease Related Death (When The Spatial Spread Of The Susceptible Is Not Negligible). Abstract.

  5. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage Road, Cambridge CB3 0FS, U.K.. Contact: Office: (+44-1223) 33 4300. Fax: (+44-1223) 33 4567. Email: jmt2@cam.ac.uk. YouTube; Twitter; Facebook; Blog ...

  6. Remembering Sir J C Bose

    Indian Academy of Sciences (India)

    In November 2008, the Indian Institute of. Science, Bangalore, organized a symposium to celebrate the 150th birth anniversary of Sir. J. C. Bose. This inspiring book is the outcome of that symposium held under the leadership of P Balaram. The book is organized into three chapters titled 'Jagdish Chandra Bose: The Man ...

  7. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  8. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  9. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  10. Decoding Ferenczi's clinical diary: biographical notes.

    Science.gov (United States)

    Brennan, B William

    2015-03-01

    In the Clinical Diary of Sándor Ferenczi, certain codes and abbreviations are used to refer to the eight patients Ferenczi was treating in 1932. The identities of two patients are known to us. Notably, Dm. (Clara Thompson), and R.N. (Elizabeth Severn), but the others have remained a mystery. This paper uncovers the identities of the other patients in the Diary, and, for the first time, reveals their identities and life stories. Biographical notes on these patients are provided to expand and contextualize our understanding of their lives-Who were they? What kind of families did they come from? And what happened to them after their analyses? The process of uncovering their identities and the ethics of writing about historical patients will also be addressed.

  11. Experiences of Biographical Crises as a Resource for Professional Interventions. An Exemplary Analysis of Lawyer's Acting

    Directory of Open Access Journals (Sweden)

    Claudia Scheid

    2008-01-01

    Full Text Available In the empirical part of the following paper, professional service is shown in the context of a biographical experience of a professional—a family law attorney. In terms of method, this undertaking is precarious. Its sense lies in gaining an understanding of the biographically and historically motivated potentials and limits of professional services. A differentiated look at professional services is facilitated when you know the stories out of which specific procedures have resulted. In overcoming the crude classification of "professionalized," "not professionalized," and "de-professionalized," it is possible to further differentiate theories of professionalization (Talcott PARSONS, Ulrich OEVERMANN, Fritz SCHÜTZE. Up until now detailed examinations are missing of the genesis of concrete professional acting, even though the topic has been worked out clearly, especially in studies of teachers' work. URN: urn:nbn:de:0114-fqs0801537

  12. Biographical Sketch: John Royal Moore, MD 1899–1988

    OpenAIRE

    Brand, Richard A.

    2011-01-01

    This biographical sketch on John R. Moore corresponds to the historic text, The Classic: Cartilaginous-cup Arthroplasty in Ununited Fractures of the Neck of the Femur (1948), available at DOI 10.1007/s11999-011-1974-z.

  13. Biographical Sketch: Baron Joseph Lister, FRCS, 1827–1912

    OpenAIRE

    Brand, Richard A.

    2010-01-01

    This biographical sketch on Baron Joseph Lister corresponds to the historic text, The Classic: On the Antiseptic Principle in the Practice of Surgery (1867), available at DOI 10.1007/s11999-010-1320-x.

  14. Biographical Sketch: Baron Joseph Lister, FRCS, 1827-1912.

    Science.gov (United States)

    Brand, Richard A

    2010-08-01

    This biographical sketch on Baron Joseph Lister corresponds to the historic text, The Classic: On the Antiseptic Principle in the Practice of Surgery (1867), available at DOI 10.1007/s11999-010-1320-x .

  15. SK Rangarajan-Biographical Sketch and Scientific Contributions

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 12. S. K. Rangarajan - Biographical Sketch and Scientific Contributions. M V Sangaranarayanan. General Article Volume 13 Issue 12 December 2008 pp 1133-1140 ...

  16. [Personality and neurosis in the biographical perspective].

    Science.gov (United States)

    Bühler, K E

    1985-01-01

    A biographical conception of neurosis requires a dynamical perspective of personality which may be defined as the relative stability of a person in time. The life-cycle is not merely a sequence of data but a complex pattern which can be reconstructed by all semiotic systems. But the ordinary all-purpose language is to be preferred because of its flexibility to fit even very complicated state of affairs. The narration of a life-cycle does not end in a unique version but a multiplicity of legitimate narratives. The unity of all these versions is conceived as paradigma, that means a set of similar examples. The extensional set of the paradigma shows a kind of order which may be characterized intensionally by a rule or a sense. The seeming irrationality of a neurotic symptom is caused by its belonging to a different paradigma for which there is a sense. Psychotherapy is an attempt to give the seeming irrational symptoms a specific sense and to change it in a second step.

  17. Keeping the Biographical Encyclopedia of Astronomers Relevant for a Generation

    Science.gov (United States)

    Rothenberg, Marc

    2017-01-01

    The Biographical Encyclopedia of Astronomers is a magnificent accomplishment, but like all such compilations, it faces potentially rapid obsolescence. Relying on my experience as an encyclopedia editor and a contributor to more than 20 other biographical reference works, I will highlight potential pitfalls for the BEA in the future and suggest ways in which the publisher can ensure that the BEA will continue to remain relevant for a generation.

  18. The SIR-2 Experiment on Chandrayaan-1

    Science.gov (United States)

    Mall, U.; Nathues, A.; SIR-2 Collaboration

    2009-04-01

    The SIR-2 experiment, flying on the Indian Chandrayaan-1 mission to the Moon, is a near-infrared point spectrometer of the second-generation built by a European collaboration around the Max-Planck Institute for Solar System Research. SIR-2 has been designed based on the heritage of the SIR Technology experiment on ESA's SMART-1 mission, in order to investigate the mineralogical composition of the Moon for a period of two years. The SIR-2 instrument, which will operate in conjunction with the Indian Hyper-Spectral Imaging spectrometer (HySI) on board Chandrayaan-1, will cover, together with HySi, a combined spectral range of 0.4 to 2.4 m. We will explain the SIR-2 experiment and report on the performance of the instrument during its commissioning phase to deliver high spatial and spectral near-infrared data from its first 100 km polar orbits around the Moon.

  19. Ḥanafī Biographical Dictionaries: A Survey

    Directory of Open Access Journals (Sweden)

    Ermin Sinanovic

    2001-06-01

    Full Text Available This paper deals with biographical dictionaries-one of the main genres in Muslim historiography. The first part involves some theoretical considerations related to biographical dictionaries. This includes definition and classification of this type of literature. In addition, this paper dismisses the claim forwarded by some Orientalists that this genre was initiated by Traditionalists so that they could pass themselves off as 'genuine' scholars to the exclusion of all others. While the Orientalists' claim may have some weight, this study contends that biographical dictionaries have been primarily motivated by the Islamic conception of historiography, i.e. the preservation of the memory of previous scholars so that later Muslim generations could emulate their deeds. The second part surveys five Ḥanafī biographical dictionaries within the framework of the questions of motive, method, selectivity, and the issue of factual information and subjective evaluation. The survey confirms the hypothesis that the composition of biographical dictionaries was genuinely inspired by religious considerations. The paper also examines the linkage among these different dictionaries, and derives several important conclusions there from. Lastly, the paper analyzes the content of the surveyed dictionaries and relates it to the theoretical considerations discussed in the first part.

  20. Lives Without Privacy: Biographical Blindness in Theory Building

    Directory of Open Access Journals (Sweden)

    Tatjana Greif

    2014-06-01

    Full Text Available Historical discourse is covered with ‘blind spots’ when dealing with historical role, active contribution, and participation in general of women. This emptiness is ever more obvious with regard to categories of women alternative to the mainstream gender model. While generally women artists as internally undifferentiated and amorphous gender monolith are purely represented within art history and research of art practice, non-hetero-normative women as a deviating minority are just ‘invisible’. It’s not only about the heteronormativism and heterosexism of the mainstream art history but also about phobias of feminist theory. The basic question is when, how and why the biographical approach in art analysis remains unresponsive to biographical specifics outside the socially affirmative mainstream, and why is it important in the biographical optic to detect lost elements through sharper-focused lance.

  1. Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

    Science.gov (United States)

    Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

    2004-12-01

    The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

  2. Exploring Biographical Learning in Danish Elite Football Coaching

    DEFF Research Database (Denmark)

    Christensen, Mette Krogh

    Exploring Biographical Learning In Danish Elite Football Coaching Mette Krogh Christensen Abstract for EASS 2011(300 words) Background: There is a growing body of studies in sports coaching cultures, comprising research focusing on the individual learning processes and life histories of elite...... football coaches (n=8) about their pathways in elite sport. Using Kvale’s recommendations, thematic analysis was conducted by the use of meaning coding. In addition, a theoretical reading of the interview was conducted on the background of Alheit’s concept of biographicity and Werthner and Trudel...

  3. H. Odera Oruka: A Biographical Sketch | Nyarwath | Thought and ...

    African Journals Online (AJOL)

    H. Odera Oruka: A Biographical Sketch. O Nyarwath. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  4. Biographical sketch: Thomas W. Huntington, MD (1849-1929).

    Science.gov (United States)

    Brand, Richard A

    2012-10-01

    This biographical sketch on Thomas Huntington corresponds to the historic text, The classic: case of bone transference. use of a segment of fibula to supply a defect in the tibia (1905), available at DOI 10.1007/s11999-012-2496-z .

  5. Representing electrons a biographical approach to theoretical entities

    CERN Document Server

    Arabatzis, Theodore

    2006-01-01

    Both a history and a metahistory, Representing Electrons focuses on the development of various theoretical representations of electrons from the late 1890s to 1925 and the methodological problems associated with writing about unobservable scientific entities. Using the electron-or rather its representation-as a historical actor, Theodore Arabatzis illustrates the emergence and gradual consolidation of its representation in physics, its career throughout old quantum theory, and its appropriation and reinterpretation by chemists. As Arabatzis develops this novel biographical

  6. Modern French Studding of the Biographical Texts: Prolegomena

    OpenAIRE

    Hromyk, Alina

    2014-01-01

    The article deals with the main directions of the studding of the biography as a text in the modern French humanities. We described the structural and the functional peculiarities of the biographical text (discourse), particularly based on the fictional biography. It is stressed on the terminology, which is used by scientists not only literary and interdisciplinary studies, particularly “fictionality”, “biofiction”, “fictional biography”. Attention is given to agents of the works and of the n...

  7. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

  8. My Time with Sir Rudolf Peierls

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 15; Issue 5. My Time with Sir Rudolf Peierls. R K Bhaduri. Article-in-a-Box Volume 15 Issue 5 May 2010 pp 394-397. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/015/05/0394-0397. Author Affiliations.

  9. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

  10. Sir Bob Edwards: Salute to a Giant

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 10. Sir Bob Edwards: Salute to a Giant. Kamal Ahuja ... Clinic, Harley Street, London, W1G 6AP. Chairman and Company Secretary, Reproductive BioMedicine Online (RBMO) Duck End Farm, Park Lane, Dry Drayton, Cambridge, CB23 8DB.

  11. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    1997-08-20

    Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda gave birth to Ronald .... generally low-caste Indians who required a fee before drinking the water and also an assurance that they ... nary demand being made upon their systems, as by fatigue, chill, or dissipation. I have even heard it ...

  12. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

  13. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    1997-08-20

    Aug 20, 1997 ... convincingly that malaria was caused by parasites present in the blood, but the important question was 'How do the germs get there?' The disease could not be prevented unless the route of infection was established! Young Ross Enters the Scene. In 1857, a General in the Indian Army, Sir C C G Ross and ...

  14. Chemical Research of Sir Prafulla Chandra Ray

    Indian Academy of Sciences (India)

    Chemical Research of Sir Prafulla Chandra Ray. Sreebrata Goswami and Samaresh Bhattacharya. Sreebrata Goswami is a. Reader at the Department of Inorganic Chemistry,. Indian Association for the. Cultivation of Science,. Calcutta. His major research interests include synthesis of coordination compounds with special.

  15. The effects of biographical variables on job satisfaction among nurses.

    Science.gov (United States)

    Curtis, Elizabeth A

    A review of the literature confirms that there is no clear picture with regard to which biographical variables are strongly correlated with job satisfaction. Studies have shown small and inconsistent effects on variables, such as age, gender, education and personality, on job satisfaction. This study aimed to determine the effect of biographical variables on job satisfaction among nurses. The study used a dominant-less dominant mixed-method design and quantitative data were collected by a postal questionnaire survey. The sample was selected using stratified random sampling. The findings demonstrated no significant differences in job satisfaction for female and male nurses, and between job satisfaction and tenure. The findings did, however, confirm that nurses under the age of 35 were less satisfied than those over the age of 36; nurses with degrees were less satisfied than those without; and nurses in senior positions are more satisfied than their junior counterparts. The findings should be interpreted with caution because of the sample size and the small correlations between variables. Limitations aside, this study provides an insight into the relationship between these variables among nurses in the Republic of Ireland. It is possible that biographical variables are distal influences on job satisfaction, but further research is needed to better understand the relationship between these two sets of variables.

  16. Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS

    NARCIS (Netherlands)

    Schrijver, Irene T; Kemperman, Hans; Roest, Mark; Kesecioglu, Jozef; de Lange, Dylan W

    2017-01-01

    BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Myeloperoxidase is a hemeprotein stored in the neutrophil azurophilic granules and

  17. Foreword: Sir John Pendry FRS Sir John Pendry FRS

    Science.gov (United States)

    Inglesfield, John; Echenique, Pedro

    2008-07-01

    scattering is much weaker, and this allowed him to develop a method of successive approximation. The material and the calculation are cut up into a series of atomic slices, and the electronic structure solved without approximation in each slice. Being two-dimensional, this was much more manageable than a full three-dimensional calculation. Then the slices could be put together by a sort of perturbation theory to calculate the scattering current as a function of energy along each of the reciprocal lattice 'rods' allowed by the surface periodicity. John didn't just stop at having solved the problem in principle, he also developed a suite of computer codes to do the job in a routine way. He even published the code for all to use, and I believe that to the present day the calculations are still done effectively in the same way. Without the calculations, one cannot interpret the data in terms of a surface atomic structure. Effectively one is doing a computer experiment in parallel to the laboratory experiment, and one fiddles more or less systematically with the surface structure until one gets agreement between the simulations and the laboratory data. One of the things that John noticed was that the process of photoemission (UPS) from a surface is rather similar, and can be calculated in an analogous way. This suddenly became very important because the new synchrotron at Daresbury was about to become operational, pumping out billions of photons for solid state research. Sam Edwards (now Sir Sam) was head of SRC (forerunner of EPSRC) at the time and recognised the problem of interpreting all the data that the machine would provide. And after UPS would come EXAFS, and after that XANES and all the rest of the alphabet soup. With that foresight, unusual at the time, John Pendry was appointed to head the theory group at Daresbury. Previously the theoreticians had revolved around the nuclear physics accelerator, and John had to turn it completely around and refocus it, which he did

  18. Rates of computational errors for scoring the SIRS primary scales.

    Science.gov (United States)

    Tyner, Elizabeth A; Frederick, Richard I

    2013-12-01

    We entered item scores for the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1991) into a spreadsheet and compared computed scores with those hand-tallied by examiners. We found that about 35% of the tests had at least 1 scoring error. Of SIRS scale scores tallied by examiners, about 8% were incorrectly summed. When the errors were corrected, only 1 SIRS classification was reclassified in the fourfold scheme used by the SIRS. We note that mistallied scores on psychological tests are common, and we review some strategies for reducing scale score errors on the SIRS. (c) 2013 APA, all rights reserved.

  19. History of Shock Waves, Explosions and Impact A Chronological and Biographical Reference

    CERN Document Server

    Krehl, Peter O. K

    2009-01-01

    This unique and encyclopedic reference work charts the evolution of the physics of shock waves and detonations from the earliest investigations into percussion and impact phenomena right up to the most recent groundbreaking research in the field. The history of this long and complex process is first reviewed in a general survey that encompasses everything from the earliest observations and interpretations of puzzling high-rate dynamic phenomena associated with natural and man-made explosions to a discussion of the merits of modern numerical computer simulations. The subject is then treated in more detail and in chronological order in the central section of the book, while also being richly illustrated in form of a picture gallery. The bibliographic index provides 122 short biographies of eminent researchers who have contributed to the field. Further references for biographical sources are given, and both name and subject indices (with over 4500 and 2700 entries, respectively) are provided. "This book is of tr...

  20. The importance of biographic research: a South African black nurses' perspective.

    Science.gov (United States)

    Mhlongo, T P

    1999-09-01

    This article is an attempt to highlight the importance of biographic research to South African nursing. The writer believes that a particular attention should be paid to the contributions of South African Black/African nurse practitioners. South Africa has produced remarkable African nurses: they range from nurse Professors and Head of the University Nursing Departments to clinical nursing specialists and nursing administrators. The writer--having used the biographical approach in his Doctoral thesis--will highlight some practical and professional issues around biographic research. For the purpose of this publication, however, discussion will be confined to defining biographic research, reviewing different types of biographies, and discussing the value of the biographical research. Furthermore, the writer will identify some biographic concepts, examine their relationships, draw inferences and (hopefully) emerge with an increased understanding of the impact of biography as scientific concept.

  1. [Sir John Charnley and total hip arthroplasty].

    Science.gov (United States)

    Burgers, Paul T P W; van Gijn, Jan

    2011-01-01

    Sir John Charnley (1911-1982), pioneer of the total hip prosthesis, saved countless elderly people from immobility. During the Second World War he assisted Dudley Buxton, orthopaedic surgeon to the British armed forces in the Middle East, in developing new instruments and splints. After the war he first studied healing of bone fractures and the role of compression, and then completely dedicated himself to arthroplasty of the hip. Through countless experiments he found the optimal diameter for the head of the stainless steel prosthesis as well as the optimal polymer for the socket; he also advocated tight cementing of the shaft into the femur. Sir John Charnley received the Lasker Award in 1974 and was knighted in 1977.

  2. SIRS in the Time of Sepsis-3.

    Science.gov (United States)

    Simpson, Steven Q

    2018-01-01

    Severe sepsis is a common, deadly, and diagnostically vexing condition. Recent recommendations for diagnosing sepsis, referred to as consensus guidelines, provide a definition of sepsis and remove the systemic inflammatory response syndrome (SIRS) as a component of the diagnostic process. A concise definition of sepsis is welcomed. However, the approach to developing these guidelines, although thorough, had weaknesses. Emphasis is placed on mortality prediction rather than on early diagnosis. Diagnostic criteria are recommended to replace current criteria without evidence of any effect that their use would have on mortality. SIRS is a prevalent feature of patients with sepsis, should remain an important component of the diagnostic process, and remains a valuable term for discussing patients with life-threatening organ dysfunction caused by infection. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  3. Dimensional reduction for a SIR type model

    Science.gov (United States)

    Cahyono, Edi; Soeharyadi, Yudi; Mukhsar

    2018-03-01

    Epidemic phenomena are often modeled in the form of dynamical systems. Such model has also been used to model spread of rumor, spread of extreme ideology, and dissemination of knowledge. Among the simplest is SIR (susceptible, infected and recovered) model, a model that consists of three compartments, and hence three variables. The variables are functions of time which represent the number of subpopulations, namely suspect, infected and recovery. The sum of the three is assumed to be constant. Hence, the model is actually two dimensional which sits in three-dimensional ambient space. This paper deals with the reduction of a SIR type model into two variables in two-dimensional ambient space to understand the geometry and dynamics better. The dynamics is studied, and the phase portrait is presented. The two dimensional model preserves the equilibrium and the stability. The model has been applied for knowledge dissemination, which has been the interest of knowledge management.

  4. The mitochondrial SIR2 related protein 2 (SIR2RP2 impacts Leishmania donovani growth and infectivity.

    Directory of Open Access Journals (Sweden)

    Nimisha Mittal

    2017-05-01

    Full Text Available Leishmania donovani, a protozoan parasite is the major causative agent of visceral leishmaniasis. Increased toxicity and resistance to the existing repertoire of drugs has been reported. Hence, an urgent need exists for identifying newer drugs and drug targets. Previous reports have shown sirtuins (Silent Information Regulator from kinetoplastids as promising drug targets. Leishmania species code for three SIR2 (Silent Information Regulator related proteins. Here, we for the first time report the functional characterization of SIR2 related protein 2 (SIR2RP2 of L. donovani.Recombinant L. donovani SIR2RP2 was expressed in E. coli and purified. The enzymatic functions of SIR2RP2 were determined. The subcellular localization of LdSIR2RP2 was done by constructing C-terminal GFP-tagged full-length LdSIR2RP2. Deletion mutants of LdSIR2RP2 were generated in Leishmania by double targeted gene replacement methodology. These null mutants were tested for their proliferation, virulence, cell cycle defects, mitochondrial functioning and sensitivity to known SIR2 inhibitors.Our data suggests that LdSIR2RP2 possesses NAD+-dependent ADP-ribosyltransferase activity. However, NAD+-dependent deacetylase and desuccinylase activities were not detected. The protein localises to the mitochondrion of the promastigotes. Gene deletion studies showed that ΔLdSIR2RP2 null mutants had restrictive growth phenotype associated with accumulation of cells in the G2/M phase and compromised mitochondrial functioning. The null mutants had attenuated infectivity. Deletion of LdSIR2RP2 resulted in increased sensitivity of the parasites to the known SIR2 inhibitors. The sirtuin inhibitors inhibited the ADP-ribosyltransferase activity of recombinant LdSIR2RP2. In conclusion, sirtuins could be used as potential new drug targets for visceral leishmaniasis.

  5. Clinical Epidemiology of SIRS and Sepsis in Newly Admitted Children.

    Science.gov (United States)

    Ganjoo, Sheetal; Ahmad, Kaisar; Qureshi, Umar Amin; Mir, Zahed Hussain

    2015-08-01

    To assess the clinical and demographic profile of Systemic Inflammatory Response Syndrome (SIRS) and sepsis, among newly admitted children in different age groups in a hospital in North India. This prospective study was conducted at a referral care centre in Northern India. All children, age group 0 to SIRS) and sepsis and to gain clinical and demographic data. The criteria laid at International consensus conference, 2002, were used to define patients as SIRS, Sepsis, Severe sepsis and Septic shock. During the study period, a total of 865 patients were screened for SIRS. Prevalence of SIRS amongst hospitalised children was 23 % (n = 201). Seventy nine percent (n = 159) of patients had infection associated SIRS and 21 % (42) had non-infective SIRS. Sixty four percent (n = 129) SIRS patients had uncomplicated sepsis, 15 % (n = 30) patients fulfilled criteria for severe sepsis. Out of the latter 30, 19 had septic shock. Organ dysfunction in SIRS was noted in 25 % (n = 51). 37.25 % (n = 19) had multiple organ dysfunction syndrome (MODS). The most common organism isolated was Staphylococcus aureus (n = 9). Focus of infection in majority was pulmonary (44 %). Mean duration of antibiotic therapy and hospital stay in the SIRS group were 6.4 and 6.5 d respectively. In the group without SIRS, mean duration were 2.44 d and 3.07 d respectively The differences were statistically significant. In conclusion, the proportion of sepsis contributing to SIRS is high in a tertiary care hospital. Therefore rapid recognition of SIRS is essential. Goal directed treatment of sepsis is also important so that high mortality associated with severe sepsis and septic shock are prevented.

  6. SIR - 2: The NIR Spectrometer for the Chandrayaan-1 Mission

    Science.gov (United States)

    Mall, U.; Nathues, A.; Keller, H. U.; SIR-2 Science Team

    2005-08-01

    SIR-2 is an upgraded, compact grating, near-infrared spectrometer, which covers the wave-length range between 0.9 and 2.45 μ m, with a spectral resolution of Δ λ pixel = 6 nm. SIR-2 has been chosen to fly on board the Indian mission Chandrayan-1 in 2007-2009. SIR-2, which will benefit from its heritage of SIR on SMART-1, will deliver, compared to SMART-1, a homogenous lunar surface coverage with unsurpassed spatial resolution and thus will greatly improve our knowledge of the lunar surface composition. The SIR-2 NIR data, combined with the hyperspectral data from the HySI instrument on Chandrayaan-1, will provide, for the first time, a full spectral coverage of the olivine and large part of the pyroxen bands, thus allowing one to extract from the data the necessary input parameters for the mineralogical mixing models. We present the SIR-2 design and discuss the potential science.

  7. A historical-biographical analysis of Kgašane | Bopape | South ...

    African Journals Online (AJOL)

    The aim of this article is to make a historical-biographical analysis of the historical drama Kgašane by SPN Makwala. The article begins by defining the key principles of a historical-biographical approach. It then locates the story of Kgašane within the Balobedu history in the late nineteenth century. This is followed by an ...

  8. 75 FR 57542 - 60-Day Notice of Proposed Information Collection: Refugee Biographic Data

    Science.gov (United States)

    2010-09-21

    ... Information Collection: Refugee Biographic Data ACTION: Notice of request for public comments. SUMMARY: The... of 1995. Title of Information Collection: Refugee Biographic Data. OMB Control Number: 1405-0102..., Refugees, and Migration, PRM/A. Form Number: N/A. Respondents: Refugee applicants for the U.S. Resettlement...

  9. Grade point average and biographical data in personal resumes: Predictors of finding employment

    NARCIS (Netherlands)

    Sulastri, A.; Handoko, M.; Janssens, J.M.A.M.

    2015-01-01

    This study aimed to examine relationships between graduates' grade point average (GPA), biographical data and success in finding a job in general and a psychology-based job in particular. Two hundred six psychology graduates participated in a two-wave longitudinal study. Biographical data assessed

  10. Learning and knowing: Narratives, memory and biographical knowledge in interview interaction

    Directory of Open Access Journals (Sweden)

    Rob Evans

    2013-04-01

    Full Text Available The qualitative research interview engages with experience of social reality in sites of social interaction. Research interview respondents provide insight in biographical interviews into the significance of critical change processes for their individual and collective learning. Auto/biographical narratives of learning, are emergent, evolving accounts produced in a learning space hedged in by the demands of the "reflexive project of the self" which throw the individual more than ever before in processes of lifelong or life-wide learning onto their biographical resources. These resources can be understood as representing individual learning processes which are capable of furthering the creation of new cultural and social structures of experience, new forms of biographical knowledge which emerge out of the precarious balancing-act between routines and learning transitions. Research interviews embedded in interaction and participant reflexivity, addressing the learning transitions told in talk, access the construction of knowledge as adults move on to new biographical spaces and position themselves anew.

  11. Differences between Structured Interview of Reported Symptoms (SIRS) and SIRS-2 sensitivity estimates among forensic inpatients: A criterion groups comparison.

    Science.gov (United States)

    Tarescavage, Anthony M; Glassmire, David M

    2016-10-01

    The Structured Interview of Reported Symptoms (SIRS) underwent a major revision in 2010 yielding the SIRS-2. The new test has since been criticized for several potential problems, particularly in terms of its sensitivity to feigned psychopathology. For this reason, the purpose of this study was to examine the concordance between SIRS and SIRS-2 classifications and sensitivity estimates in an archival sample of 263 criminal defendants (215 males, 48 females) who were admitted to a high-security state psychiatric hospital for restoration of competency to stand trial. In a subgroup of 39 presumed feigning patients who elevated 1 or more collateral measures of feigning (primarily the M-FAST) at conservative cutoffs, we found marked discrepancies between the sensitivity of the SIRS (.87) and SIRS-2 (.54). The marked differences in sensitivity were partially explained by a global interpretation discordance rate of 47%, with discordance primarily resulting from SIRS-based feigning cases being classified as indeterminate on the SIRS-2. Follow-up analyses of intercorrelations and percentile distributions indicated that the new SIRS-2 scales may lack utility in the assessment of feigning because of problems relating to the construct validity of the scales and their interpretive cutoffs. Future directions in research and clinical practice are discussed, with added emphasis on the significant limitations of archival pretrial forensic samples for identifying presumed genuine groups necessary to calculate specificity estimates (which were meaningfully higher for the SIRS-2 in this sample). Overall, the primary clinical implication is that feigning should remain a strong consideration in SIRS-2 cases yielding an indeterminate classification. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  12. Investigating the Interaction of Graphic Organizers and Seductive Details: Can a Graphic Organizer Mitigate the Seductive-Details Effect?

    Science.gov (United States)

    Rowland-Bryant, Emily; Skinner, Christopher H.; Skinner, Amy L.; Saudargas, Richard; Robinson, Daniel H.; Kirk, Emily R.

    2009-01-01

    The interaction between seductive details (SD) and a graphic organizer (GO) was investigated. Undergraduate students (n = 207) read a target-material passage about Freud's psychosexual stages. Depending on condition, the participants also read a biographical paragraph (SD-only), viewed a graphic organizer that linked the seductive details to the…

  13. Using carer biographical narratives to explore factors involved in proxy reporting of quality of life in people with dementia.

    Science.gov (United States)

    Robertson, Jane M

    2017-04-01

    Quality of life is an important focus of research on dementia, with interest in direct reports of people with dementia and proxy reports of their carers. By exploring the subjective perspectives of unpaid family carers and paid care workers, this study aims to understand how carers construct meaning in narratives about quality of life with dementia. A case-centred approach involved biographical narrative interviews with 10 carers to explore what was important for people with dementia to have a good quality of life. Detailed narrative analysis attended to the linguistic and structural features of accounts to consider how dementia is conceptualised by carers in the framing of quality of life. An individual's perception of how dementia impacts on awareness and behaviour was central to their understanding of quality of life. Carers who constructed dementia as a loss of skills and abilities were able to represent quality of life in positive terms despite the challenges of dementia. Carers who constructed dementia as eroding identity represented quality of life less positively and centred on their own means of coping with a challenging care situation. Findings highlight the importance of helping carers develop positive constructions of quality of life that are associated with understanding dementia as a loss of skills and abilities, rather than as a loss of self. Engaging with subjectivity in carers' biographical narrative accounts is important in the development of quality of life assessment to understand the meanings and emotions that underlie proxy perspectives.

  14. Social change in the perspective of biographical reflection

    Directory of Open Access Journals (Sweden)

    Danuta Lalak

    2011-12-01

    Full Text Available The modern world is interpreted and described in terms of an autobiographical society, in which the fundamental issues of human life are resolved in the process of an individual decision and being involved in a peculiar type of a dialog. This dialog is more and more often a dialog with oneself and an author’s vision of the world created in the confrontation with virtual reality. In this epoch context the biography is taken into account as a tool for perceiving, understanding and describing the change of the world and the human’s place in the world. Even though, the biography has functioned in social life forever, only now with the epoch of individualization, and then virtualization of life, its formative character has been noticed. Who is the subject of (autobiography? Who is it aimed at as a message and testimony of life? How is it created? Why is it constructed? Who is it constructed by? And then the questions which are behind the autobiography in the theoretical sense – What is life? How do we discover it? What is the link between telling about life and living the life? How is the telling (living about a life connected with culture and history? How does reading (interpreting about life connect with telling about life and the truth about life? Social development phases coupled with transformations within biographical reflection have been distinguished: life in a traditional world – the culture of telling about life; the birth of individualism (the individualization of experience – the culture of describing life; the discovery of identity – the culture of reading about life; life in the net and cyberspace – the culture of constructing life; the new communalism – the culture of seeking the meaning of life. Every stage of biographical reflection enables us to distinguish new forms of creating, understanding and using it in both the humanities and social life, but also in ordinary people’s life. The direction of changes sketched

  15. Serum levels of osteopontin are increased in SIRS and sepsis.

    Science.gov (United States)

    Vaschetto, Rosanna; Nicola, Stefania; Olivieri, Carlo; Boggio, Elena; Piccolella, Fabio; Mesturini, Riccardo; Damnotti, Federica; Colombo, Davide; Navalesi, Paolo; Della Corte, Francesco; Dianzani, Umberto; Chiocchetti, Annalisa

    2008-12-01

    In sepsis, dysregulation of the immune response leads to rapid multiorgan failure and death. Accurate and timely diagnosis is lifesaving and should discriminate sepsis from the systemic inflammatory response syndrome (SIRS) caused by non-infectious agents. Osteopontin acts as an extracellular matrix component or a soluble cytokine in inflamed tissues. Its exact role in immune response and sepsis remains to be elucidated. Therefore, we investigated the role of osteopontin in SIRS and sepsis. Prospective, observational study. Intensive care unit of a university hospital. Fifty-six patients with SIRS or sepsis and 56 healthy subjects were enrolled. We analyzed the serum levels of osteopontin and TH1-TH2 cytokines and investigated the role of osteopontin on interleukin 6 secretion by monocytes. Serum osteopontin levels were strikingly higher in patients than in controls and in sepsis than in SIRS, and decreased during the resolution of both the disorders. Receiver operating characteristic curves showed that osteopontin levels have discriminative power between SIRS and sepsis with an area under the curve of 0.796. Osteopontin levels directly correlated with those of interleukin 6 and in vitro, recombinant osteopontin increased interleukin 6 secretion by monocytes in both the absence and presence of high doses of lipopolysaccharide. These data suggest that osteopontin might be a mediator involved in the pathogenesis of SIRS and sepsis, possibly by supporting interleukin 6 secretion. 45. SIRS/Sepsis: clinical studies.

  16. Estimates for Future Tenure, Satisfaction and Biographical Variables as Predictors of Termination

    Science.gov (United States)

    Waters, L. K.; And Others

    1976-01-01

    Findings of this study indicate that an employee's estimate of his/her future tenure with a company is a more reliable indication of actual tenure than job-satisfaction or biographical factors. (Author/RW)

  17. (AutoBiographical Research in post-structural key: conversations with Judith Butler

    Directory of Open Access Journals (Sweden)

    Clívio Pimentel Júnior

    2017-01-01

    Full Text Available In this theoretical essay, we investigated approaches and tensions between Butler‟s thoughts and the field of (AutoBiographical Educational Research. We focused initially on historical, theoretical and methodological aspects of (AutoBiographical Research, especially on the national scenario, highlighted in presentations of thematic dossiers, association letters and review papers. Then, we discussed the challenge involved in the approximation between the theoretical assumptions of (AutoBiographical Research and philosophical assumptions of the Post-structural movement. Finally, we argued in defense of plausibility and theoretical consistency of approach between post-structuralism and (AutoBiographical Research considering the possibility of invention of performative and post-metaphysical narratives of oneself.

  18. LE PARENT BIOGRAPHE. ÉTUDE DES ECRITURES PARENTALES ET JOURNAUX DE NAISSANCE. PARENT BIOGRAPHERS. FAMILY SCRIPTURES AND BIRTH DIARIES

    Directory of Open Access Journals (Sweden)

    Francis, Véronique

    2011-11-01

    Full Text Available Cet article examine les écritures parentales autour de la naissance et de la prime enfance. Bribes biographiques ou énoncés développés accompagnant ou non la photographie, ces écrits peuvent s’insérer dans les rubriques d’un journal de naissance du secteur de l’édition, être archivés dans un cahier au nom de l’enfant ou s’afficher sur Internet grâce au support électronique du blog. Plusieurs études qualitatives (FRANCIS, 2006, 2007, 2010 ont permis de croiser différents types de données : la structure et l’organisation de journaux de naissance, les textes réalisés par les futurs parents et parents, ainsi que des entretiens réalisés auprès des familles - parents et enfants - ayant pour objectif d’aborder les pratiques familiales autour de ces objets. Les résultats montrent que les écritures parentales donnent à voir des représentations sur la famille, l’enfance et le rôle du parent. A la frontière des « écritures du moi » et des « écrits pour autrui » (SIMONET-TENANT, 2001 ; LEJEUNE et BOGAERT, 2006 les journaux de naissance peuvent être définis comme des objets à connotation mémorielle. Ils sont l’occasion d’activités langagières qui cherchent, dans un premier temps, à fixer par l’écrit et l’image l’histoire familiale puis, dans un second temps, à évoquer et transmettre la mémoire familiale. Si l’étude des pratiques familiales autour des blogs et journaux de naissance souligne les figures du parent biographe (FRANCIS, 2006 et le rôle de l’enfant, elle situe également l’activité biographique du parent dans son ampleur socialisatrice.This paper examines the parental writings about birth and infancy. Biographic fragments or texts, with or without photographies, can fit into the sections of a baby record book. They can also be archived in babies’ diaries or on the Internet, in the family’s blog. Several qualitative researches (FRANCIS, 2006, 2007, 2010 cross various

  19. A comparison of leadership styles with respect to biographical characteristics

    Directory of Open Access Journals (Sweden)

    Javad Afshari

    2017-01-01

    Full Text Available Research purpose: Managers, when applying their leadership styles, are affected by some of their own traits. This article intends to compare the leadership styles of the managers of Zabol University of Medical Sciences with respect to Hersey and Blanchard model that was based on their biographical characteristics.Research design, approach and method: The research methodology is descriptive-causal and comparative. The data were collected from 300 individuals (124 female and 176 male participants.Main findings: No significant difference was observed between the directive, persuasive, participative and delegative leadership styles of male and female managers. However, there was a significant difference between the mean of the directive, persuasive, participative and delegative leadership styles of managers, considering their work experience, education level and field of study.Research limitations: The conservative atmosphere in university environments may affect the manager’s responses to the questionnaire; therefore, in the generalisation of the results, this issue should be taken into account.Practical implications: It is recommended to hold in-service courses for managers who have a lower education level or less work experience or have been graduated from the fields of study other than the Management major. It is also suggested to pay attention to the managers’ fields of study and managerial experiences at the time of employment.Contribution: This study enhances the quality of managers’ leadership style and consequently increases the productivity in university environments. 

  20. The Pasteurization of Marie Curie: A (meta)biographical experiment.

    Science.gov (United States)

    Wirtén, Eva Hemmungs

    2015-08-01

    Biographies of scientists occupy a liminal space, highly popular with general readers but questioned in academia. Nonetheless, in recent years, historians of science have not only embraced the genre with more enthusiasm and less guilt, they have also turned to the metabiography in order to renew the study and story of scientists' roles. This essay focuses on Marie Curie, the world's most famous female scientist, in order to unpack some of the theoretical and methodological claims of the science biography, and especially to address the sexing mechanisms at play in the construction of the biographical subject. Pierre Curie (1923), Marie's biography of her husband Pierre, paid tribute to her dead husband and collaborator, but also allowed Curie a legitimate outlet to construct her own persona and legacy. Categories such as personhood, person, and persona are not only central to the biography genre but also are essential to the sense of self and self-fashioning of scientists. Looking at how Marie Curie negotiated these categories in Pierre Curie not only gives new insight into Curie's self-fashioning strategies but may also shed some light on the more general analytical lacunae of the science biography.

  1. Identifying British Army infantry recruit population characteristics using biographical data.

    Science.gov (United States)

    Kiernan, M D; Arthur, A; Repper, J; Mukhuty, S; Fear, N T

    2016-04-01

    The infantry accounts for more than a quarter of the British Army but there is a lack of data about the social and educational background of its recruits. To provide an insight into British Army infantry recruits' personal, social and educational background prior to enlistment. The study sample consisted of infantry recruits who enlisted into the British Army School of Infantry. Each recruit completed a 95-item biographical questionnaire. Descriptive statistics were used to describe the sample in terms of demographic, physical, personal, social and educational attributes. The study sample consisted of 1000 male recruits. Over half of the recruits were consuming alcohol at a hazardous or harmful level prior to enlistment and 60% of recruits had used cannabis prior to joining the Army. Academic attainment was low, with the majority of recruits achieving GCSE grade C and below in most subjects, with 15% not taking any examinations. Over half the recruits had been in trouble with the police and either been suspended or expelled from school. Substance misuse and poor behaviour are highly prevalent among recruits prior to enlistment. Taken alongside existing evidence that some of these problems are commonplace among personnel in regular service, the assumption that the British Army infantry is, in itself, a cause of these behaviours should be questioned. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. A comparison of leadership styles with respect to biographical characteristics

    Directory of Open Access Journals (Sweden)

    Javad Afshari

    2017-04-01

    Full Text Available Research purpose: Managers, when applying their leadership styles, are affected by some of their own traits. This article intends to compare the leadership styles of the managers of Zabol University of Medical Sciences with respect to Hersey and Blanchard model that was based on their biographical characteristics. Research design, approach and method: The research methodology is descriptive-causal and comparative. The data were collected from 300 individuals (124 female and 176 male participants. Main findings: No significant difference was observed between the directive, persuasive, participative and delegative leadership styles of male and female managers. However, there was a significant difference between the mean of the directive, persuasive, participative and delegative leadership styles of managers, considering their work experience, education level and field of study. Research limitations: The conservative atmosphere in university environments may affect the manager’s responses to the questionnaire; therefore, in the generalisation of the results, this issue should be taken into account. Practical implications: It is recommended to hold in-service courses for managers who have a lower education level or less work experience or have been graduated from the fields of study other than the Management major. It is also suggested to pay attention to the managers’ fields of study and managerial experiences at the time of employment. Contribution: This study enhances the quality of managers’ leadership style and consequently increases the productivity in university environments.

  3. Biographical and demographical variables as moderators in the prediction of turnover intentions

    OpenAIRE

    Janine du Plooy; Gert Roodt

    2013-01-01

    Orientation: The aim of the study was to explore the possible moderation effects of biographical and demographical variables on a prediction model of turnover intention (TI). Research purpose: The main purpose of the study was to determine how biographical and demographical variables have an impact on predictors of turnover intentions. Motivation for the study: Twenty-first century organisations face significant challenges in the management of talent and human capital. One in particul...

  4. Context, Experience, Expectation, and Action—Towards an Empirically Grounded, General Model for Analyzing Biographical Uncertainty

    Directory of Open Access Journals (Sweden)

    Herwig Reiter

    2010-01-01

    Full Text Available The article proposes a general, empirically grounded model for analyzing biographical uncertainty. The model is based on findings from a qualitative-explorative study of transforming meanings of unemployment among young people in post-Soviet Lithuania. In a first step, the particular features of the uncertainty puzzle in post-communist youth transitions are briefly discussed. A historical event like the collapse of state socialism in Europe, similar to the recent financial and economic crisis, is a generator of uncertainty par excellence: it undermines the foundations of societies and the taken-for-grantedness of related expectations. Against this background, the case of a young woman and how she responds to the novel threat of unemployment in the transition to the world of work is introduced. Her uncertainty management in the specific time perspective of certainty production is then conceptually rephrased by distinguishing three types or levels of biographical uncertainty: knowledge, outcome, and recognition uncertainty. Biographical uncertainty, it is argued, is empirically observable through the analysis of acting and projecting at the biographical level. The final part synthesizes the empirical findings and the conceptual discussion into a stratification model of biographical uncertainty as a general tool for the biographical analysis of uncertainty phenomena. URN: urn:nbn:de:0114-fqs100120

  5. Personal growth in chronic illness - a biographical case study of living with fibromyalgia.

    Science.gov (United States)

    Kalitzkus, Vera; Matthiessen, Peter F

    2010-01-01

    Chronic illness can be distressing for patients. It confronts them with the challenge of having to cope with their life and of having to adjust their self-image. Nevertheless, patients often experience that they go through a process of personal growth. Although there is empirical proof of the potential that coping with severe illness has with regard to personal growth, fairly little is known about the conditions that bring about such a development. Based on a singlecase study of fibromyalgia (FM) from Germany, the paper reveals the potential of a biographical approach for understanding the process of personal growth in chronic illness. The case is part of a qualitative study on the occurrence of biographical transformation in severe illnesses. A narrative, biographical interview was conducted with the patient. The analysis takes objective biographical data as well as the subjective experience of the patient into account. Our analysis is confirmed by qualitative studies on the subjective experience of FM. Although these studies report a favorable development with some FM sufferers, they neither investigate its significance for the life of the patient nor the factors that make personal growth possible. We tried to identify biographical resources and personal strategies of the patient that facilitated her inner growth. A biographical approach is a way towards understanding individual growth in the face of severe suffering. By including the patients' objective life data as well as their subjective experiences, deeper insights into the process of personal growth can be gained. Copyright 2010 S. Karger AG, Basel.

  6. Sir William Mitchell (1925-2002)

    CERN Document Server

    2002-01-01

    Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

  7. One day, Sir, you may tax it

    CERN Multimedia

    2011-01-01

    “One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

  8. Validation of the Spanish SIRS with monolingual Hispanic outpatients.

    Science.gov (United States)

    Correa, Amor A; Rogers, Richard; Hoersting, Raquel

    2010-09-01

    Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.

  9. Correspondence of Sir Isaac Newton and Professor Cotes

    National Research Council Canada - National Science Library

    Edleston, J; Newton, Isaac; Cotes, Roger

    1969-01-01

    ... of Sir Isaac Newton and Professor Cotes. An index, prepared under the General Editor's supervision, has been added at the end of the volume.This page intentionally left blank Table of ContentsCON...

  10. Dynamical Behavior of a stochastic SIRS epidemic model

    OpenAIRE

    Hieu, N. T.; Du, N. H.; Auger, P.; Dang, N. H.

    2015-01-01

    In this paper we study the Kernack - MacKendrick model under telegraph noise. The telegraph noise switches at random between two SIRS models. We give out conditions for the persistence of the disease and the stability of a disease free equilibrium. We show that the asymptotic behavior highly depends on the value of a threshold $\\lambda$ which is calculated from the intensities of switching between environmental states, the total size of the population as well as the parameters of both SIRS sy...

  11. Ingmar Bergman, the biographical legend and the intermedialities of memory

    Directory of Open Access Journals (Sweden)

    Maaret Koskinen

    2010-12-01

    Full Text Available Ingmar Bergman (1918–2007 wrote his autobiography The Magic Lantern (Laterna magica, 1987 5 years after he had finished his film career with Fanny and Alexander, his last feature made for the cinema screen. This arguably marked the second stage of his strictly literary career, the first being his plays for the stage in the 1940s. The Magic Lantern is of interest from an intermedial perspective in its forthright theatricalization or cinematization of the written text and the self-conscious performativity of its authorial voice. Of particular interest is the way the narrator turns into a kind of distanciated autobiographical witness, which in turn reminds the reader of the inherent narrative split in the autobiographical genre between the enunciating subject speaking from the present, and the described subject, the younger self in the past. In doing so the narrator seems to turn language itself into a performative venue: the medium of words becomes a theatrical stage or a cinematically charged mise-en-scène for memory as such.This is of course not only stylistically elegant, for what can be more natural than a film- and theater director who, as the very title of the autobiography announces, turns memories into cinematic and theatrical performances? But even more interesting is the extent to which Bergman in doing so seems to conjur forth his biographical legend, reminding the reader of who is in charge of text: the narrator becomes the director of the text, so to speak, lighting and setting the stage.Besides this artful approach, Bergman also clearly fictionalized his life in other ways, which is corroborated by the private note books and original manuscripts that the writer of this paper has gained access to.

  12. The “Biographical Lives” of Missionary Barend Schuurman : Spatial and Temporal Contexts in Biographical Renderings of Schuurman’s Life

    NARCIS (Netherlands)

    Busschers, Iris

    2017-01-01

    This article engages with the genre of missionary biography through the lens of the life of Dutch missionary Barend Schuurman and the biographical commemorations of him. Missionary Barend Schuurman worked in East Java from 1922 until he died as a prisoner of the Japanese during World War II. After

  13. Development of Immunopathobiogenesis on SIRS-Sepsis

    Directory of Open Access Journals (Sweden)

    A Guntur Hermawan

    2009-04-01

    Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.

  14. Global Stability of Multigroup SIRS Epidemic Model with Varying Population Sizes and Stochastic Perturbation around Equilibrium

    Directory of Open Access Journals (Sweden)

    Xiaoming Fan

    2014-01-01

    Full Text Available We discuss multigroup SIRS (susceptible, infectious, and recovered epidemic models with random perturbations. We carry out a detailed analysis on the asymptotic behavior of the stochastic model; when reproduction number ℛ0>1, we deduce the globally asymptotic stability of the endemic equilibrium by measuring the difference between the solution and the endemic equilibrium of the deterministic model in time average. Numerical methods are employed to illustrate the dynamic behavior of the model and simulate the system of equations developed. The effect of the rate of immunity loss on susceptible and recovered individuals is also analyzed in the deterministic model.

  15. Lymphocyte integrin expression differences between SIRS and sepsis patients.

    Science.gov (United States)

    Heffernan, D S; Monaghan, S F; Ayala, Alfred

    2017-11-01

    Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically β1 (CD29) and β2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (β2) and CD29 (β1) on CD3 + T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. CD18 was almost ubiquitously expressed on CD3 + T cells irrespective of clinical condition. However, CD29 (β1 integrin) was lowest in SIRS patients (20.4% of CD3 + T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3 + CD29 + T cells (41.7%) when compared with those with non-abdominal sources (29.5%). Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.

  16. Dodging the Literary Undertaker – Biographic Metafiction in Hanif Kureishi’s The Last Word

    Directory of Open Access Journals (Sweden)

    Chalupský Petr

    2017-07-01

    Full Text Available Hanif Kureishi’s 2014 novel, The Last Word, involves most of the author’s idiosyncratic themes, such as ethnicity, racism, sexual identity, examination of interpersonal relationships and the crucial role of the creative imagination in human life. Its focal concern, however, is to explore the process of writing a literary biography of a living person and the character and dynamics of the relationship between the biographer and his subject - a writer. As such, the novel can be taken as being representative of biographic metafiction, a subcategory of historiographic metafiction, which, following the postmodernist questioning of our ability to know and textually represent historical truth, presents biographic writing critically or even mockingly, rendering its enthusiastic practitioners’ efforts with ironic scepticism. The aim of this article is to present The Last Word as a particular example of biographic metafiction that has all the crucial features of this genre, yet which differs from its predecessors through the complexity and thoroughness of its portrayal of the biographer-biographee relationship.

  17. Biographical Self-Reflection as a Resource for Personal Development in Adults

    Directory of Open Access Journals (Sweden)

    Klementyeva M.V.,

    2016-04-01

    Full Text Available The paper focuses on the stages in the development of mind in adults related to biographical self-reflection. The hypothesis of the study was that biographical self-reflection affects meaning-making, self-regulation and adaptation in the adults. The sample consisted of 480 individuals aged 25—65 years. The study measured indicators of biographical self-reflection, social psychological adaptation, life meaningfulness and self-regu- lation. We have found that in the age period of 46-65 years there is a shift from self-reflection on the path of life to self-reflection on life experience, which reinforces the influence of biographical self-reflection on the meaningfulness of life and self-regulation in the adults. Our study also revealed increases in biographical self-reflection at the beginning of age crises in adulthood (30—35, 40—45, 55—60 years when, as a result of reflective analysis, the adult realizes the need for change in his/her life.

  18. Differential expression of plasma miR-146a in sepsis patients compared with non-sepsis-SIRS patients.

    Science.gov (United States)

    Wang, Lina; Wang, Hua-Cheng; Chen, Cha; Zeng, Jianming; Wang, Qian; Zheng, Lei; Yu, Huan-DU

    2013-04-01

    Sepsis is a subtype of systemic inflammatory response syndrome (SIRS), which is characterized by infection. Circulating microRNAs (miRNAs), including miR-150, miR-146a and miR-223, are potential biomarkers of sepsis. In this study, we demonstrated that measuring the relative expression of miR-146a/U6 in plasma, using the 2 -ΔΔCt method, provides a method for differentiating between sepsis and non-sepsis-SIRS. We observed a significant increase in miR-146a expression in the initial cohort of 6 non-sepsis-SIRS patients compared to the 4 sepsis patients (P=0.01) and in the second cohort of 8 non-sepsis-SIRS patients compared to the 10 sepsis patients (P=0.027). Additionally, we identified that sodium citrate and ethylenediaminetetraacetic acid (EDTA) K 2 may be used as anticoagulant reagents. Generation of a standard curve is not necessary in these diagnostic tests, unless the standard of normalization is carefully selected. Thus we provide more detailed guidance for the clinical use of circulating miRNA biomarkers.

  19. Author Details

    African Journals Online (AJOL)

    Ogunsola, AW. Vol 10 (2006) - Articles Biomechanics of the brain; some remarks on Biot\\'s equations of consolidation theory with deformation-dependent permeability. Abstract · Vol 17 (2010) - Articles Effect of transmission rate in an SIR epidemic model. Abstract. ISSN: 1116-4336. AJOL African Journals Online. HOW TO ...

  20. Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS.

    Science.gov (United States)

    Schrijver, Irene T; Kemperman, Hans; Roest, Mark; Kesecioglu, Jozef; de Lange, Dylan W

    2017-09-15

    Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Myeloperoxidase is a hemeprotein stored in the neutrophil azurophilic granules and is one of the main pillars of neutrophil attack. Therefore, we hypothesized that myeloperoxidase can differentiate between sepsis and non-infectious SIRS in patients with systemic inflammatory response syndrome in the intensive care unit (ICU). An observational single-center cohort study was conducted measuring myeloperoxidase in patients with SIRS in the first 48 h after admission. The outcomes were established using predefined definitions. Thirty-day mortality was retrospectively assessed. We found significantly higher levels of myeloperoxidase in patients with sepsis and septic shock compared to patients without sepsis (60 ng/ml versus 43 ng/ml, P = 0.002). Myeloperoxidase levels were related to 30-day mortality (P = 0.032), and high MPO levels on top of a high APACHE IV score further increased mortality risk. We show that myeloperoxidase is a potentially novel biomarker for sepsis in the ICU. Myeloperoxidase could eventually help in diagnosing sepsis and predicting mortality. However, more research is necessary to confirm our results.

  1. Knowledge and recognition of SIRS and sepsis among pediatric nurses.

    Science.gov (United States)

    Jeffery, Alvin D; Mutsch, Karen Steffen; Knapp, Lisa

    2014-01-01

    A large amount of research demonstrates the importance of key interventions in reducing mortality rates of pediatric patients with sepsis (Dellinger et al., 2008). Assessment and recognition of declining status must occur for interventions to be initiated. Of health care practitioners, nurses typically spend the most time with patients, and they must be knowledgeable in recognizing the systemic inflammatory response syndrome and sepsis while also being aware of the importance of prompt intervention. The literature does not discuss pediatric nurses' knowledge of systemic inflammatory response syndrome (SIRS)/sepsis recognition. The purpose of this study was to assess the knowledge of acute and critical care pediatric nurses of SIRS diagnostic criteria, sepsis guidelines, and the importance of SIRS recognition. This cross-sectional, quantitative, correlational descriptive study included 242 acute and critical care pediatric nurses at a 490-bed urban pediatric hospital. Participants completed an original questionnaire with face and content validity regarding SIRS criteria, sepsis guidelines, priority interventions, and attitude toward the importance of SIRS recognition. Findings demonstrated a significant knowledge deficit among participants in several key areas of SIRS/sepsis recognition. The mean score was 60.8% ± 7.4%. Item analyses demonstrated nurses easily recognize septic shock but have difficulty recognizing patients in earlier stages of the sepsis continuum. Significant confusion was evident regarding the role of blood pressure and serum lactic acid levels in diagnosing sepsis. It is recommended that an educational intervention be created for acute and critical care pediatric nurses to aid them in recognizing sepsis in its earlier stages.

  2. Biograph. A package in R to explore life history data and to enchance multistate modelling of life histories

    NARCIS (Netherlands)

    Willekens, F.J.C.

    2011-01-01

    Biograph: Explore life histories Biograph is designed to facilitate the descriptive and statistical analysis of life histories. It follows a multistate perspective on the life course and conceptualizes the life course as a sequence of states and transitions between states (events). Transitions are

  3. Performance of the SIR-B digital image processing subsystem

    Science.gov (United States)

    Curlander, J. C.

    1986-01-01

    A ground-based system to generate digital SAR image products has been developed and implemented in support of the SIR-B mission. This system is designed to achieve the maximum throughput while meeting strict image fidelity criteria. Its capabilities include: automated radiometric and geometric correction of the output imagery; high-precision absolute location without tiepoint registration; filtering of the raw data to remove spurious signals from alien radars; and automated catologing to maintain a full set of radar and image production facility in support of the SIR-B science investigators routinely produces over 80 image frames per week.

  4. Sir William Osler's speech at Troy: a Trojan horse?

    OpenAIRE

    Moran, Michael E.

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length...

  5. SIR-2 Data Normalization and Integration with M3 Data

    Science.gov (United States)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  6. The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study.

    Science.gov (United States)

    Comstedt, Pål; Storgaard, Merete; Lassen, Annmarie T

    2009-12-27

    Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. A hundred and fifty-four patients (35%) had SIRS on admission, 211 patients (48%) had no SIRS, and 72 patients (16%) had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p SIRS patients with 15/154 SIRS patients versus 3/211 non-SIRS patients: p = 0.001, RR 6.9 (95% CI 2.0-23.3). Most of the deaths among patients with SIRS occurred among patients with malignant conditions. Septic shock developed in 4/154 (3%) of the patients with SIRS, whereas this occurred in only one of the 211 patients (0.5%) without SIRS on arrival: p = 0.08, RR 5.5 (95% CI 0.6-48.6). We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

  7. Role of biographical experience and bodily sensations in patients' adaptation to hypertension

    DEFF Research Database (Denmark)

    Sångren, H; Reventlow, S; Hetlevik, I

    2009-01-01

    practices in Denmark. The informants differed in type and duration of treatment. RESULTS: Adaptation to hypertension was influenced by the patients' biographical experiences and involved changes in body perception. The process affected patients' daily activities and they actively tested their physical...

  8. Implications for research and practice of the biographic approach for storytelling.

    Science.gov (United States)

    Ewens, Beverley; Hendricks, Joyce; Sundin, Deb

    2017-01-23

    Background Intensive care unit survivors face many physical and psychological difficulties during their recovery following discharge from hospital. These difficulties can significantly affect their quality of life. Healthcare providers and survivors' families often do not understand what recovery means in this population, which may affect the support provided. Aim To consider the potential of the biographical method in helping to create stories that illustrate recovery in intensive care survivors and other populations. Discussion This paper identifies how the biographical approach has provided survivors with a way to uncover the hidden parts of their lives through diaries and interviews, and reveal the hidden stories of intensive care survivorship and recovery. Conclusion The application of the biographical method enabled stories to be created that identified the disruption survivors encounter as they struggle to appear recovered. Implications for practice The biographical method can illuminate experiences uncaptured by other methods. This insight into recovery journeys can help healthcare practitioners and family members to understand and recognise the need for support during recovery.

  9. Educating for Vocational Excellence: The Auto/Biographical Exploration of Enacted Craft Pedagogy

    Science.gov (United States)

    Tyson, Ruhi

    2015-01-01

    The focus of this article is on education for vocational excellence (the combination of virtue and good judgment or phronesis/practical wisdom) through an examination of episodes from the auto/biographical study of master craftsman Wolfgang B. Vocational excellence is an issue sometimes discussed with regard to teacher training for schools and…

  10. Some Biographical Correlates of Outstanding Performance among School Principals. Report No. 35.

    Science.gov (United States)

    Gottfredson, Gary D.; Hybl, Lois G.

    Biographical data about verifiable accomplishments, collected in a structured questionnaire format, could contribute to the selection of school principals or early identification of persons to be developed for eventual succession into the principalship. Three criterion groups, selected to represent increasing levels of average performance,…

  11. 76 FR 9849 - 30-Day Notice of Proposed Information Collection: Refugee Biographic Data, OMB Control Number...

    Science.gov (United States)

    2011-02-22

    ... DEPARTMENT OF STATE [Public Notice 7339] 30-Day Notice of Proposed Information Collection: Refugee... accordance with the Paperwork Reduction Act of 1995. Title of Information Collection: Refugee Biographic Data... Originating Office: Bureau of Population, Refugees, and Migration, PRM/A Form Number: N/A Respondents: Refugee...

  12. Cross-Cultural Approaches to Biographical Interviews: Looking at Career Transitions and Lifelong Learning

    Science.gov (United States)

    Barabasch, Antje; Merrill, Barbara

    2014-01-01

    This article focuses on the methodological approaches used in the European Centre for the Development of Vocational Training (Cedefop) research project "Learning for Career and Labour Market Transitions--individual biographies". In particular, it illuminates how biographical approaches were employed to help the in-depth understanding of…

  13. Author Details

    African Journals Online (AJOL)

    Agossou, S.M. Désiré. Vol 113 (2017) - Articles Analyse de la rentabilité financière de la production de semence du riz au Bénin Abstract PDF. ISSN: 1997-5902. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  14. Sir RA Fisher and the Evolution of Genetics

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 9. Sir R A Fisher and the Evolution of Genetics. Amitabh Joshi. General Article Volume 2 Issue 9 September 1997 pp 27-31. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/002/09/0027-0031 ...

  15. Sir Alfred Bray Kempe–An Amateur Kinematician

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 3. Sir Alfred Bray Kempe-An Amateur Kinematician. A K Mallik. General Article Volume 16 Issue 3 March 2011 pp 204-218. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/016/03/0204-0218 ...

  16. On the Shoulders of Sir Isaac Newton and Arthur Storer

    Science.gov (United States)

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  17. Vegetation and Soil Characteristics in SIR-C data

    NARCIS (Netherlands)

    Broek, A.C. van den; Rijckenberg, G.J.; Davidson, M.; Freeman, A.

    1995-01-01

    We compared polarimetric C- and L-band and ground truth data from bare soil, young wheat and mature maize fields of the agricultural test site Flevoland in the Netherlands collected during the SIR-C campaign in April and October 1994. We find that the L-band is more sensitive to the soil roughness

  18. Ready Reference Tools: EBSCO Topic Search and SIRS Researcher.

    Science.gov (United States)

    Goins, Sharon; Dayment, Lu

    1998-01-01

    Discussion of ready reference and current events collections in high school libraries focuses on a comparison of two CD-ROM services, EBSCO Topic Search and the SIRS Researcher. Considers licensing; access; search strategies; viewing articles; currency; printing; added value features; and advantages of CD-ROMs. (LRW)

  19. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  20. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  1. Investigating The Travelling Wave Solution For an SIR Endemic ...

    African Journals Online (AJOL)

    This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

  2. Reflection on the "New Dynamics" of Distance Education: An Interview with Sir John Daniel

    Science.gov (United States)

    Latchem, Colin

    2012-01-01

    This article presents an interview with Sir John Daniel outgoing President and CEO of the Commonwealth of Learning. Sir John Daniel's term as President and Chief Executive Officer of the Commonwealth of Learning (COL) ended on May 31, 2012. Readers of "Distance Education" will know of Sir John's work at the Tele-universite (Directeur des…

  3. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

  4. Inflammatory Syndromes (SIRS, MARS, CARS) in Patients with Surgical Infection.

    Science.gov (United States)

    Ostanin, Alexander A.; Leplina, Olga Yu.; Shevela, Caterina Ya.; Kozhevnikov, Vladimir S.; Chernykh, Helen R.

    2000-10-01

    In the present study 37 patients with surgical infection were investigated and a new set of diagnostic tests for detection of major syndromes of systemic inflammation - systemic inflammatory response syndrome (SIRS), compensatory anti-inflammatory response syndrome (CARS) and mixed antagonist response syndrome (MARS) - was developed. In summary, we have demonstrated that patients with surgical infection were characterized by an immunodeficiency with significant reduction of mitogen-induced proliferation and IL-2/IL-4 production in vitro combined with decrease of HLA DR(+) monocytes. Furthermore, it was revealed that the patient's serum exhibited substantially enhanced suppressive and inflammatory activities as well as the level of C-reactive protein. We have defined the negative correlation between the serum inflammatory and suppressive activities (SIA and SSA) that was most prominent at the early stage of disease. Since the changes of serum bioactivity in the course of surgical infection were prominent and coherent, we supposed that tested activities might reflect the distinctive features of systemic inflammation. In according to this assumption, the patients were divided into 3 subgroups with predominance of SIRS, CARS and MARS by using the SIA and SSA expression. It has been shown that SIRS was more frequently detected at the early stage, whereas CARS - at the late stage of disease. Patients with SIRS, CARS or MARS significantly differed by the content of CD8(+) T and CD72(+) B lymphocytes, the concentration of IgG and IgA, the production of IL-2 and IL-4. Finally, the data obtained from patients, those were studied repeatedly, showed the possibility of transformation of the major systemic inflammatory syndromes during the disease course. Our findings suggest that measurement of serum inflammatory and suppressive activities may help to differentiate patients with SIRS, CARS or MARS and to select the appropriate strategy of immunotherapy.

  5. The Herschel objects and how to observe them exploring sir William Herschel's star clusters, nebulae, and galaxies

    CERN Document Server

    Mullaney, James

    2007-01-01

    Deep-sky observers are always on the lookout for new observing challenges. "The Herschel Objects, and How to Observe them" offers an exciting opportunity to retrace the footsteps of Sir William Herschel, discoverer of Uranus and arguably the greatest visual observer and celestial explorer that ever lived!Following a biography of Herschel that details his life and the telescopes he used, this practical observer's guide lists all the most impressive of Herschel's star clusters, nebulae and galaxies.More than 600 of the brightest of the objects that Herschel observed are covered, and there are detailed descriptions and images of almost 200 of the very best Herschel objects for amateur astronomers.

  6. SIR/CAR Analysis Technique for Voluntary School Sport or Amateur Athletic Organizations. A SIR/CAR Application.

    Science.gov (United States)

    Moriarty, Dick; Zarebski, John

    This paper delineates the exact methodology developed by the Sports Institute for Research/Change Agent Research (SIR/CAR) for applying a systems analysis technique to a voluntary mutual benefit organization, such as a school or amateur athletic group. The functions of the technique are to compare avowed and actual behavior, to utilize group…

  7. Stability Analysis of SIR Model with Distributed Delay on Complex Networks.

    Directory of Open Access Journals (Sweden)

    Chuangxia Huang

    Full Text Available In this paper, by taking full consideration of distributed delay, demographics and contact heterogeneity of the individuals, we present a detailed analytical study of the Susceptible-Infected-Removed (SIR epidemic model on complex population networks. The basic reproduction number [Formula: see text] of the model is dominated by the topology of the underlying network, the properties of individuals which include birth rate, death rate, removed rate and infected rate, and continuously distributed time delay. By constructing suitable Lyapunov functional and employing Kirchhoff's matrix tree theorem, we investigate the globally asymptotical stability of the disease-free and endemic equilibrium points. Specifically, the system shows threshold behaviors: if [Formula: see text], then the disease-free equilibrium is globally asymptotically stable, otherwise the endemic equilibrium is globally asymptotically stable. Furthermore, the obtained results show that SIR models with different types of delays have different converge time in the process of contagion: if [Formula: see text], then the system with distributed time delay stabilizes fastest; while [Formula: see text], the system with distributed time delay converges most slowly. The validness and effectiveness of these results are demonstrated through numerical simulations.

  8. Comparability of Structured Interview of Reported Symptoms (SIRS) and Structured Interview of Reported Symptoms-Second Edition (SIRS-2) Classifications With External Response Bias Criteria.

    Science.gov (United States)

    Tylicki, Jessica L; Wygant, Dustin B; Tarescavage, Anthony M; Frederick, Richard I; Tyner, Elizabeth A; Granacher, Robert P; Sellbom, Martin

    2018-02-01

    Rogers, Sewell, and Gillard (2010) released a revised version of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992), the SIRS-2, which introduced several new scales, indices, and a new classification model with the overall goal of improving its classification of genuine versus feigned presentations. Since the release of the SIRS-2, several concerns have been raised regarding the quality of the SIRS-2 development and validation samples and the method used to calculate classification accuracy estimates. To further explore issues related to the clinical utility of the SIRS-2, the current study examined associations of the SIRS and SIRS-2 with the Minnesota Multiphasic Personality Inventory-2-Restructured Form (Ben-Porath & Tellegen, 2008/2011) validity scales in separate samples of disability claimants and criminal defendants. Results indicate that the SIRS-2 reduced the number of feigning classifications. Additional analyses suggest that the Modified Total Index and Supplementary Scale Index do not assess the test-taking strategy that Rogers and colleagues (2010) intended the indices to capture. External data indicates that evaluees reclassified on the SIRS-2 in nonfeigning categories exhibited feigned symptoms of psychopathology. Indeed, we found that SIRS-identified feigners showed significant evidence of overreporting on the Minnesota Multiphasic Personality Inventory-2-Restructured Form validity scales, regardless of their SIRS-2 classification. The current study highlights the overall weakness in clinical utility of the SIRS-2. Implications of these results for both clinical and forensic settings are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  9. Likelihood of obtaining Structured Interview of Reported Symptoms (SIRS) and SIRS-2 elevations among forensic psychiatric inpatients with screening elevations on the Miller Forensic Assessment of Symptoms Test.

    Science.gov (United States)

    Glassmire, David M; Tarescavage, Anthony M; Gottfried, Emily D

    2016-12-01

    The Miller Forensic Assessment of Symptoms Test (M-FAST) was designed as a screening measure for feigned psychiatric symptoms. When M-FAST Total Scores are elevated (raw score ≥6), the test manual recommends follow-up with a more comprehensive measure of feigning, such as the widely used and researched Structured Interview of Reported Symptoms (SIRS) or the revised version of the test (SIRS-2). The purpose of the current study was to evaluate how often M-FAST screening elevations are associated with subsequent elevations on the SIRS or SIRS-2. The sample included archival data from 100 forensic psychiatric inpatients who obtained M-FAST Total Score elevations ≥6 during screening and were subsequently administered the SIRS (that was also rescored using SIRS-2 criteria). Among examinees who elevated the M-FAST over the recommended cutoff, 66.0% met standard SIRS feigning criteria, 42% met SIRS-2 criteria for feigning, and 81.0% obtained at least 1 SIRS/SIRS-2 elevation in the Probable Feigning range or higher. These results are consistent with the M-FAST manual guidelines, which support the use of the ≥6 M-FAST cutoff score to screen for potential feigning (but not as an independent marker of feigning). A higher M-FAST cutoff score of ≥16 was associated with subsequently meeting full SIRS criteria for feigning in 100.0% of protocols. Because the SIRS criteria were designed to have very low false positive rates, these findings indicate that more confident assertions about feigning can be made when elevations reach this level on the MFAST. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  10. Systemic Inflammatory Response Syndrome (SIRS) Score Independently Predicts Poor Outcome in Isolated Traumatic Brain Injury.

    Science.gov (United States)

    Jacome, Tomas; Tatum, Danielle

    2018-02-01

    Systemic inflammatory response syndrome (SIRS) is frequently observed after various types of acute cerebral injury and has been linked to clinical deterioration in non-traumatic brain injury (TBI). SIRS scores have also been shown to be predictive of length of stay and mortality in trauma patients. We aimed to determine the prognostic utility of SIRS present at admission in trauma patients with isolated TBI. This was a 5-year retrospective cohort study of adults (≥18 years) with isolated TBI admitted to a Level II trauma center. The prognostic value of SIRS, total SIRS scores, and each SIRS criterion was examined by Χ 2 and logistic regression analyses. Of the 330 patients identified, 50 (15.2%) met SIRS criteria. SIRS was significantly associated with poor outcome (P SIRS score of 2 on admission (P = 0.007) and increased significantly to 6.5 times in patients with a SIRS score of 3 (P = 0.002). Logistic regression demonstrated SIRS and each criterion to be significant independent prognostic factors (SIRS, P = 0.030; body temperature, P = 0.006; tachypnea, P = 0.022, tachycardia P = 0.023). SIRS at admission is an independent predictor of poor outcome in isolated TBI patients. These data demonstrate SIRS to be an important clinical tool that may be used in facilitating prognostication, particularly in elderly trauma patients. Future prospective studies aimed at therapeutic interventions to mitigate SIRS in TBI patients are warranted. Prognostic, Level III.

  11. The Systemic Inflammatory Response Syndrome (SIRS in acutely hospitalised medical patients: a cohort study

    Directory of Open Access Journals (Sweden)

    Storgaard Merete

    2009-12-01

    Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

  12. The susceptible-infected-recovered (SIR) model for viral marketing

    Science.gov (United States)

    Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

    2017-11-01

    Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

  13. SIR-B cartography and stereo topographic mapping

    Science.gov (United States)

    Kobrick, M.; Leberi, F.; Raggam, J.; Domik, G.; Welch, R.; Carr, H.; Hammak, J.; Kaupp, V.; Macdonald, H. C.; Waite, W. P.

    1984-01-01

    The SIR-B mapping experiment which will evaluate the utility of SAR images taken singularly, in pairs, and in combination with other data sets for cartographic, topographic, and thematic mapping, and determine the optimum configuration of a SAR system for future mapping mission is outlined. SIR-B is the first orbital imaging radar mission which will incorporate maintenance of geometric image fidelity along with careful calibration and documentation of internal timing and frequency parameters. This along and and the multiple incidence angle images of the same target which are necessary for stereoscopy and topographic mapping, make it the ideal opportunity for cartographic experimentation. It is emphasized that comprises a significant part of the overall experiment objectives.

  14. Plasma biomarkers of SIRS and MODS associated with canine babesiosis.

    Science.gov (United States)

    Kuleš, J; de Torre-Minguela, C; Barić Rafaj, R; Gotić, J; Nižić, P; Ceron, J J; Mrljak, V

    2016-04-01

    Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. Early detection of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is of major importance in clinical practice for providing information about severity and outcomes of the disease and therapy. Plasma samples were taken at admission from five dogs with uncomplicated babesiosis caused by B. canis canis, five dogs with babesiosis and SIRS, five dogs with babesiosis and MODS, and five healthy dogs. After two-dimensional electrophoresis and capillary reversed - phase liquid chromatography coupled online with tandem mass spectrometry, 68 differentially expressed spots with level of significance PSIRS in babesiosis was characterised by increases in paraoxonase 1 and apoA-I, whereas MODS with decrease of complement inhibitors leading to prolonged complement activation and decrease of vitamin D binding protein due to haemolysis and activation of the coagulation cascade. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Epidemiology of the Systemic Inflammatory Response Syndrome (SIRS) in the emergency department.

    Science.gov (United States)

    Horeczko, Timothy; Green, Jeffrey P; Panacek, Edward A

    2014-05-01

    Consensus guidelines recommend sepsis screening for adults with systemic inflammatory response syndrome (SIRS), but the epidemiology of SIRS among adult emergency department (ED) patients is poorly understood. Recent emphasis on cost-effective, outcomes-based healthcare prompts the evaluation of the performance of large-scale efforts such as sepsis screening. We studied a nationally representative sample to clarify the epidemiology of SIRS in the ED and subsequent category of illness. This was a retrospective analysis of ED visits by adults from 2007 to 2010 in the National Hospital Ambulatory Medical Care Survey (NHAMCS). We estimated the incidence of SIRS using initial ED vital signs and a Bayesian construct to estimate white blood cell count based on test ordering. We report estimates with Bayesian modified credible intervals (mCIs). We used 103,701 raw patient encounters in NHAMCS to estimate 372,844,465 ED visits over the 4-year period. The moderate estimate of SIRS in the ED was 17.8% (95% mCI: 9.7 to 26%). This yields a national moderate estimate of approximately 16.6 million adult ED visits with SIRS per year. Adults with and without SIRS had similar demographic characteristics, but those with SIRS were more likely to be categorized as emergent in triage (17.7% versus 9.9%, pSIRS patients. Traumatic causes of SIRS comprised 10% of presentations; other traditional categories of SIRS were rare. SIRS is very common in the ED. Infectious etiologies make up only a quarter of adult SIRS cases. SIRS may be more useful if modified by clinician judgment when used as a screening test in the rapid identification and assessment of patients with the potential for sepsis. [West J Emerg Med. 2014;15(3):329-336.].

  16. Stability and bifurcation analysis in a delayed SIR model

    International Nuclear Information System (INIS)

    Jiang Zhichao; Wei Junjie

    2008-01-01

    In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

  17. Laboratory Diagnosis of Sepsis? No SIRS, Not Just Yet

    Science.gov (United States)

    2015-01-01

    In order to maximize the benefit of prompt antimicrobial therapy and avoid the risk associated with inappropriate use of antimicrobial agents, patients with suspected sepsis must be rapidly differentiated from patients with systemic inflammatory response syndrome (SIRS). In combination with standard microbiological testing, a number of biomarkers have been recently evaluated for this purpose, and the performance characteristics of the most promising of these are reviewed. PMID:25631808

  18. Explanation of Relationships between Biographical Characteristics and Entrepreneurship Spirit of Students

    Directory of Open Access Journals (Sweden)

    Hassanali Aghajani

    2012-01-01

    Full Text Available Three major causes of the importance of entrepreneurship are making wealth, developing technology and creating productive employment. It is generally believed that a revolution is needed for entrepreneurship to take place in societies nowadays. Thus, the present study aims at investigation of the biographical characteristics and explanation of its relation to entrepreneurial spirit at Mazandaran university students. The data collection instrument was a related questionnaire with the reliability level of 0.90, and the collected data related to the examined variables were analyzed by using T-Student and ANOVA Tests. The results explained and determined that, except age, other biographical characteristics including gender, marital status, employment, birth arrangement, parents‟ education level, did not have any meaningful relationship with the entrepreneurial spirit. Finally, it is the presented summary of implications for managers such as suggestions on how the managers and authorities can improve the entrepreneurial spirit among students, as well as directions for further researches.

  19. Review: Barbara Merril & Linden West (2009. Using Biographical Methods in Social Research

    Directory of Open Access Journals (Sweden)

    Vanessa Garcia Diaz

    2011-11-01

    Full Text Available The return of the subject in the social sciences reflects growing interest in the study of subjectivity. This refers to opportunities for individuals to make meaning of their lives within the institutions of society. MERRIL and WEST’s text serves as a reference for using biographical methods, as well as a reflection on the methodological and ethical issues inherent in doing this type of research.  This review examines the relationship between the book's content and its formal characteristics (didactic style, writing style and its interdisciplinary nature. This review also focuses on the advantages that this textbook may offer if used in  qualitative research courses in general and, specifically, in courses dealing with biographical research methods. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1201104

  20. Incremental Validity of Biographical Data in the Prediction of En Route Air Traffic Control Specialist Technical Skills

    Science.gov (United States)

    2012-07-01

    Previous research demonstrated that an empirically-keyed, response-option scored biographical data (biodata) : scale predicted supervisory ratings of air traffic control specialist (ATCS) job performance (Dean & Broach, : 2011). This research f...

  1. Attending to biographical disruption: the experience of rehabilitation following tetraplegia due to spinal cord injury.

    Science.gov (United States)

    Bourke, John A; Hay-Smith, E Jean C; Snell, Deborah L; DeJong, Gerben

    2015-01-01

    To explore the experience of rehabilitation from the perspective of individuals with tetraplegia. Semi-structured interviews of between 40 and 60 min were conducted with three men and one woman, with spinal injuries at C7 or higher, within 6 months of discharge from inpatient spinal cord injury (SCI) rehabilitation. Data were subject to an Interpretive Phenomenological Analysis (IPA). Participants described their injuries as more than a biological impairment that limited certain functional abilities. For them, SCI was a sudden event that also disrupted one's "life biography". Interviews uncovered three key themes essential to an individual's ability to restore feelings of self-agency and biographical continuity: The importance of information, regaining control, and restoring a sense of personal narrative. Findings from studies using IPA have much to contribute to discussion and debate at the level of rehabilitation theory and can guide future research directions. The findings of the present study support a growing body of literature that argues that rehabilitation research needs to focus more intensely on the biographical disruption caused by SCI. Implications for Rehabilitation Participants in the present study experienced a significant disruption to their biographical narratives following a SCI as they entered an unknown and uncertain world. The findings from the present study provide an evidence-base that is best applied to discussion regarding psychosocial adjustment at the level rehabilitation theory. The concepts of identity and biographical disruption are appearing more frequently in qualitative literature and both merit further investigation to assess their prevalence among the wider SCI populations.

  2. The Biographical Approach in Case Work with Right Wing Extremist Girls and Young Women

    Directory of Open Access Journals (Sweden)

    Michaela Köttig

    2008-01-01

    Full Text Available Because of the growing number of right wing extremist youths in Germany, it has become increasingly necessary in social work to develop forms of professional practice, which deal with the orientations of these adolescents in an effective way. Current social work concepts of the work with right wing extremist youth ("accepting" versus "confrontational" approaches tend to isolate specific aspects of the problem and thus remain inadequate. Notably, there exists a lack of understanding of the complex interrelationships of right wing extremist orientations emerging from biographical processes as well as family history and social conditions, consequently creating an inability to effectively cope with these issues. This article is based on a study of the group dynamics in right wing milieus of adolescents and about the processes. It focuses especially on girls and young women (KÖTTIG, 2004. On the basis of case examples, an attempt will be made to show that the above-mentioned social work concepts are too narrow and that a "holistic," i.e. a biographical, perspective leads to deeper insights into right wing extremist orientations and activities. A biographical understanding of cases can lead to the discovery of starting points for social work interventions and can generate a process of self-understanding among the girls and young women as well. Such types of assistance make it possible for them to reflect on their political orientations in such a way that remaining in the neo-Nazi milieu can lose importance for them. A biographical approach lends itself to a transfer between doing research in the social sciences and casework in social work. URN: urn:nbn:de:0114-fqs080124

  3. Making sense of others: The use of biographical statements in Rosaura a las Diez

    Directory of Open Access Journals (Sweden)

    Teófilo Espada-Brignoni

    2018-02-01

    Full Text Available Marco Denevi’s Rosaura a las Diez is a novel that explores the complex relationships between law, science, and everyday life. These fields of human experience play a fundamental role in the construction of the social categories and biographical statements individuals use to understand their world. This article draws from the works of Michel Foucault and Erving Goffman to analyse the way in which Denevi explores individuals making sense of themselves and others.

  4. Writing in Ethnographic and Auto/biographical Approaches: Old and New Challenges

    OpenAIRE

    González Monteagudo, José

    2013-01-01

    In this paper I consider the importance of writing in qualitative approaches, particularly in Ethnography, as well as the implications of the crisis of ethnographic representation in relation to auto/biographical approaches. My paper has above all an exploratory dimension. I intend to review some relevant and recent publications in social sciences (with a specific focus on ethnographic approaches, both in Sociology and Anthropology) in order (1) to reflect on discourse, rhetoric, voice, audie...

  5. Sir William Turner (1832-1916) - Lancastrian, anatomist and champion of the Victorian era.

    Science.gov (United States)

    Wessels, Quenton; Correia, Janine Carla; Taylor, Adam M

    2016-11-01

    Sir William Turner, a Lancastrian, was renowned as a scientist, anatomist and a great reformer of medical education. His students became anatomists at various international institutions, which consequently shaped the future of anatomy as a subject matter both in the United Kingdom and in South Africa. Although Turner's accomplishments have been documented, little is known about the details that determined his career path and the individuals that shaped his future. Here the authors aim to highlight some aspects of Turner's academic achievements and his personal life as well as how he crossed paths with other great minds of the Victorian era including Richard Owen, Charles Darwin, James Paget and Joseph Lister. © The Author(s) 2015.

  6. Analysing the relationship between traumatic biographical events and the current structural functioning of personality.

    Science.gov (United States)

    Schiltz, L; Schiltz, J

    2008-01-01

    We present the general structure of a multi-annual research project. Our general expectancy concerns the possibilities of arts psychotherapy as a means of launching the blocked process of subjectivation with people suffering from exclusion, precarity and marginalization. The research project follows a complex research design with a sequential strategy, the first part consisting in an integrated psychosocial and clinical study using a mixed methodology. We constructed special rating scales for the analysis of the data of a semi-structured biographical interview and also for the holistic interpretation of the Rotter Blank Sentences Test, separating the associations to sentences beginning with the third and first person. The correlations between two sets of variables (biographical interview and Rotter test) were computed for the total experimental group (N=206), and for clinical subgroups. We shall analyse the matrices of correlations (Spearman's Rho) with the help of optimal scaling procedures (OVERALS). The links between traumatic biographical events and responses to the 3rd, respectively 1st person items of the Rotter test are interpreted in terms of unconscious versus conscious psychological processes and allow us analysing the expression of defence mechanisms and coping strategies. The results of the study are discussed in the light of the recent traumatogenic hypothesis of borderline functioning.

  7. Biographical ruptures and flows in the family experience and trajectory of children with cystic fibrosis.

    Science.gov (United States)

    Castellanos, Marcelo Eduardo Pfeiffer; Barros, Nelson Filice de; Coelho, Sandra Straccialano

    2018-02-01

    Biographical disruption (BD) became a core concept of sociological studies on the chronic illness experience by showing how this event can be strongly affected by ruptures in the ways of living and organizing the biographical trajectory through narratives. Critical reviews have pointed out that the widespread use of this concept was not sufficiently attentive to its analytical limits, e.g. addressing experiences of children with genetic diseases, when biographic flows (BF) rather than BD would be probably found. In this paper, we employed the concepts of BD and BF to analyze the relationships between the illness trajectories of children with cystic fibrosis (CF) and the experiences of their parents, taking into account the narratives about their histories and family contexts, drawn from semi-structured interviews with 10 children with CF and 14 family members. The results pointed to potentialities and limits of the concepts of BD and BF for the analysis undertaken in this study. We conclude that both concepts can be applied to the analysis of family experience involving child genetic diseases, provided that this occurs in a critical and sensitive way to subjects and contexts investigated, keeping in mind the more broader theoretical concerns.

  8. Socialization and gendered biographical agency in a multicultural migration context : the life history of a young Moroccan woman in Germany

    OpenAIRE

    Al-Rebholz, Anil

    2014-01-01

    "In light of the challenges of globalization, hybridization of cultures, and transnational migration movements worldwide, some central deficits of socialization theory have been identified. As a response to these challenges, the necessity of developing 'biographical socialization research' and a 'subject-oriented socialization theory' are underlined. In this paper, the notion of 'biographical agency', embedded in the social and temporal context of biographies, is proposed to overcome shortcom...

  9. Prevalence of systemic inflammatory response syndrome (SIRS) in hospitalized children: a point prevalence study.

    Science.gov (United States)

    Pavare, Jana; Grope, Ilze; Gardovska, Dace

    2009-04-03

    In accordance with the 1st International pediatric sepsis consensus conference, where sepsis was defined as SIRS associated with suspected or proven infection, we have identified the need to assess the prevalence of SIRS and sepsis in children with abnormal temperatures hospitalized in The Children's Clinical University Hospital in Latvia. A descriptive prospective point prevalence study (using two time periods, each 24 h, randomly chosen) was conducted on all children (n = 943) treated in the hospital. All children with abnormal temperatures - fever or hypothermia (n = 92) - were included in the study. Questionnaires evaluating age-specific SIRS criteria were completed. The prevalence of SIRS was detected with 95% CI. Out of a total of 943 patients treated in the hospital, 10% (n = 92) had abnormal temperatures. In all these cases the abnormal temperature was a fever; hypothermia was not established in any patient. Of the children with fever, 72% (n = 66) had SIRS. Of the SIRS patients, 8% (n = 5) developed sepsis, 5% (n = 3) severe sepsis and 2% (n = 1) septic shock. Seventy-six percent (n = 50) of the SIRS patients had fever in combination with respiratory rate >2 SD above normal for age; 50% (n = 33) had fever with abnormal leukocyte count; 15% (n = 10) had fever with tachycardia >2 SD above normal for age. Most of the SIRS patients (39%, n = 25) were aged 2-5 years. Twenty-one percent (n = 14) of the children with SIRS and 50% (n = 2) of those with severe sepsis and septic shock had an underlying disease. In no case was SIRS and sepsis recognized by doctors and the diagnoses were not recorded on the patients' cards. Our results would indicate a high risk for sepsis development in children with SIRS. Early SIRS diagnosis and awareness of risk of developing sepsis could change the medical approach to the patient in everyday clinical practice, eventually leading to early, goal-directed therapy for sepsis.

  10. The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study

    OpenAIRE

    Storgaard Merete; Comstedt Pål; Lassen Annmarie T

    2009-01-01

    Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship t...

  11. Sir Rudolf Peierls Selected private and scientific correspondence

    CERN Document Server

    Lee, Sabine

    2007-01-01

    This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

  12. SIR rumor spreading model in the new media age

    Science.gov (United States)

    Zhao, Laijun; Cui, Hongxin; Qiu, Xiaoyan; Wang, Xiaoli; Wang, Jiajia

    2013-02-01

    With the prevalence of new media, e.g., microblogging, rumors spread faster and wider than ever before. On the basis of prior studies, this paper modifies a flow chart of the rumor spreading process with the SIR (Susceptible, Infected, and Recovered) model, and thus makes the rumor spreading process more realistic and apparent. The authors believe that ignorants will inevitably change their status once they are made aware of a rumor by spreaders; the probabilities that a spreader becomes a stifler are differentiated in accordance with reality. In the numerical simulation part, the impact that variations of different parameters have on the rumor spreading process will be analyzed.

  13. The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study

    DEFF Research Database (Denmark)

    Comstedt, Pal; Storgaard, Merete; Lassen, Annmarie T

    2009-01-01

    ABSTRACT: BACKGROUND: Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The rel......ABSTRACT: BACKGROUND: Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count....... The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. METHODS: We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status......, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. RESULTS: A hundred and fifty-four patients (35%) had SIRS on admission, 211 patients (48%) had no SIRS, and 72 patients (16%) had insufficient data to evaluate their SIRS status. SIRS patients were 2...

  14. [A prospective study for systemic inflammatory response syndrome (SIRS) after cerebral infarction].

    Science.gov (United States)

    Xue, Yuan-yuan; Xu, Xiao-yun; Li, Gang; Wang, Yue

    2008-12-01

    To investigate whether systemic inflammatory response syndrome (SIRS) after cerebral infarction is associated with poor outcome and its associated clinical factors. We prospectively studied 500 patients with cerebral infarction, recorded the associated clinical factors on presentation and calculated the mortality at 21st day. There are 85 SIRS patients in 500 patients with cerebral infarction, 31 with total anterior cerebral infarction (TACI), 34 with partial anterior cerebral infarction (PACI), 15 with posterior cerebral infarction (POCI) and 5 with lacunar cerebral infarction (LACI). The frequency of SIRS was positively correlated with mortality rate according to Oxfordshire Community Stroke Project (OCSP) subtypes in cerebral infarction patients with fever (Spearman correlation coefficient = 1.0; P SIRS and mortality of cerebral infarction were as follows: age, infection, 48 h Chinese Stroke Scale score, 48 h Glasgow score, OCSP subtypes and dysphagia. Diabetes was the risk factor for SIRS, but had no effect on mortality. On Cox regression, 48 h Glasgow score was the sole independent risk factor of outcome. However, if SIRS was included in the formula, P > 0.05. SIRS is the predictor of poor outcome after acute cerebral infarction. It is important to prevent SIRS especially in TACI and POCI. Diabetes is the risk factor for SIRS, but has no effect on mortality.

  15. [SIRS (systemic inflammatory response syndrome): clinical entity, definitions, and the significance].

    Science.gov (United States)

    Kushimoto, S; Yamamoto, Y

    1999-01-01

    The clinical entity, definitions, and the significance of SIRS (systemic inflammatory response syndrome) were reviewed. The term, SIRS was proposed to define sepsis and its sequelae clearly in 1991, in order to make early detection of the disease possible, and to improve the ability to compare innovative potential diagnostic and therapeutic modalities by standardizing terms. Although the criteria of SIRS is not strict and too sensitive, SIRS has been shown to be useful as a warning sign of severe condition in clinical setting. We also discussed about a new concept, CARS (compensatory anti-inflammatory response syndrome), which was characterized as anti-inflammatory mediators-dominant condition, in this issue.

  16. Biographic Parallels as a Basis for Typological Studying of George Orwell and Ivan Bahrianyi Works

    Directory of Open Access Journals (Sweden)

    Svitlana Korshunova

    2014-11-01

    Full Text Available This article deals with the problem of biographic parallelism as a basis for typological research. The main task is to find out similarities and differences in the works by George Orwell and Ivan Bahrianyi, all of them being based of the real facts from the writers' lives. The peculiarities of the literary interpretation of the biography of the both authors become the comparative basis for revealing of the common processes in their works. The research sheds the light on the interdependence between authors' motivations and its literary results. It also highlights the problem of genres chosen by the writers and of the dependence of this choice on the biographic facts usage. The article compares the genres of the authors' works from the point of view of their artistic motivation. The subject under study includes such books of the authors as “Burmese Days”, “Keep the Aspidistra Flying” and other by George Orwell, as well as “The Getsyman Garden”, “The Hunters and the Hunted” and others by Ivan Bahrianyi. It deals with the problem of the influence of the writers' biographic facts on their creation of the literary images and characters, as well as on the plots of the stories. The similarities between authors and their characters are revealed and this allows us to say that writers used their own lives as a source of inspiration and artistic motivation for the sake of making their stories credible. The article also raises the question of the nature of the writers' characters with authors' being their possible prototypes. In general, the article studies the parallels of George Orwell and Ivan Bahrianyi lives, trying to prove their compatibility in the typological field while both use their biographies as a creative method.

  17. Homoeroticism in Men and Women in the Colombian Coffee Axis: an Interpretation Using the Biographical Approach

    Directory of Open Access Journals (Sweden)

    Gabriel Gallego Montes

    2016-01-01

    Full Text Available As background to the study, the article highlights the use of biographical surveys as a recent application in the field of sexuality; for this reason it has been an approach little used to understand socio-sexual events and transitions in men or women engaging in homoerotic practices. In this study, a retrospective survey (biographical of 408 men and 301 women between 18 and 55 years of age engaging in homoerotic practices was applied in the Colombian Coffee Axis in 2012. The information was analyzed using birth and pairing variables, a key strategy for interpreting biographical information. A review was also done of the press and literature for 1921-1985 with regards to homoeroticism. The findings show that until the 1960s, the written press in the Coffee Axis had few references to homosexuality, and any that were made were associated with loss of moral and good customs, with a call to the authorities to exercise control. In the Seventies the transvestite body emerges, associated with transgression of gender and criminality. Subsequently, the 1985-2011 period is marked by a strong institutionalization of erotic and affective life, expressed in the growing preponderance of gay bars and the internet as a setting that configures socio-sexual interactions. Similarly, there is a trend to a shorter duration of relationships between people of the same sex. In terms of pairing, 63% of women have sexual biographies permeated by heterosexuality; in men this proportion reaches 40%; men are more monogamous when they establish a same sex relationship than women (86.5% vs. 74.5 %. In it’s conclusions the study highlights the complex network of homoeroticism in a particular region, where diverse sexual practices, simultaneous and sometimes non-exclusive, interweave; this implies the overcoming of the dichotomous view of homoeroticism and heterosexuality as isolated camps.

  18. Osterbrock Prize Lecture: The Coming to Be of the Biographical Encyclopedia of Astronomers

    Science.gov (United States)

    Hockey, Thomas A.

    2017-01-01

    The four-volume Biographical Encyclopedia of Astronomers (and cosmologists), second edition, is one of a kind: There is no discipline-specific counterpart in the physical or biological sciences. The BEA is the work of 430 authors, translators, and editors who produced biographies of approximately 1,800 persons, from the beginning of history to the beginning of the era of Big Science. How did this happen? The Editor-in-chief will give a “behind the pages” view of the construction of this first-look, first-reached-from-the-shelf reference work.

  19. An Analysis of Feminism in Maya Angelou's Poems by Using Historical and Biographical Approaches

    OpenAIRE

    Permatasari, Indiani Eka

    2016-01-01

    This study analyzes discrimination toward black woman which appears in Maya Angelou's poems. In this case, the researcher chose three poems of Maya Angelou. Those are “Still I Rise”, “Phenomenal Woman”, and “Caged Bird”. In other to discover them, the study was conducted by using feminism theory and also historical and biographical approaches. It focuses on words, lines, and stanzas of the poems. The research was conducted with the following statement of problems: (1) What is the dominant ty...

  20. Sir William Osler's speech at Troy: a Trojan horse?

    Science.gov (United States)

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

  1. Biographical Wardrobes

    DEFF Research Database (Denmark)

    Skjold, Else

    2016-01-01

    Much “Fashion thinking” is concerned with the new, the trend leading and the spectacular. Hence, much debate and theorization within this area of research focuses on fashion as a generic, institutionalized and ritualized system that continuously produces and disseminates new trends and ideals....... A large body of knowledge has been developed that aims to comprehend how fashion trends emerge and connect to society and subsequently get promoted by a system of trend agencies, fashion designers, or fashion editors. In contrast to this line of thinking, other areas of research have been looking...

  2. Breast cancer diagnosis: biographical disruption, emotional experiences and strategic management in Thai women with breast cancer.

    Science.gov (United States)

    Liamputtong, Pranee; Suwankhong, Dusanee

    2015-09-01

    In this article we draw on Bury's theory of biographical disruption to discuss the meanings of, and emotional experiences related to, being diagnosed with breast cancer among southern Thai women. Qualitative methods, including in-depth interviewing and drawing methods, were used to collect data from 20 women with breast cancer. The women perceived breast cancer to be a rhok raai; an evil or dread disease. They believed that breast cancer would lead to death. The disruption in their biography occurred when they detected abnormalities indicating breast cancer. The women's narratives revealed their chaotic lives upon this diagnosis and the news precipitated in them shock, fear, anxiety and loss of hope. Although they experienced chaos and disruption, the women cultivated strategies that helped them cope with their experiences by accepting their fate and adhering to Buddhist beliefs and practices. Through their narratives of biographical disruption, the women in our study offer healthcare providers knowledge that could lead to an appreciation of their needs and concerns. This knowledge is crucial for health professionals who wish to provide emotional support to women who have been diagnosed with breast cancer in Thailand and elsewhere. © 2015 Foundation for the Sociology of Health & Illness.

  3. Biographical and demographical variables as moderators in the prediction of turnover intentions

    Directory of Open Access Journals (Sweden)

    Janine du Plooy

    2013-04-01

    Full Text Available Orientation: The aim of the study was to explore the possible moderation effects of biographical and demographical variables on a prediction model of turnover intention (TI. Research purpose: The main purpose of the study was to determine how biographical and demographical variables have an impact on predictors of turnover intentions. Motivation for the study: Twenty-first century organisations face significant challenges in the management of talent and human capital. One in particular is voluntary employee turnover and the lack of appropriate business models to track this process. Research design, approach, and method: A secondary data analysis (SDA was performed in a quantitative research tradition on the cross-sectional survey sample (n = 2429. Data were collected from a large South African Information and Communication Technologies (ICT sector company (N = 23 134. Main findings: The results of the study confirmed significant moderation effects regarding race, age, and marital status in the prediction equations of TIs. Practical and managerial implications: Practical implications of the study suggested increased understanding of workforce diversity effects within the human resource (HR value chain, with resultant evidence-based, employee retention strategies and interventions. Issues concerning talent management could also be addressed. Contribution and value-add: The study described in this article took Industrial/Organisational (I/O psychological concepts and linked them in unique combinations to establish better predictive validity of a more comprehensive turnover intentions model.

  4. Memorial and biographical history of Spain: El jinete polaco by Antonio Muñoz Molina

    Directory of Open Access Journals (Sweden)

    Felipe Oliver Fuentes Kraffczyk

    2012-12-01

    Full Text Available The novel El jinete polaco by Antonio Muñoz Molina is a highly complex work in which the narrator mixes multiple plotlines in an effort to recreate or remember part of his family past. In the process, the collective memory of the town and people of Mágina (an allegoric space that represents the peasant life of the olive growers of southern Spain appears as a rich and contradictory montage of dreams and failures. And in a third level of discourse, the recent past of Spain also emerges through the main historic al events: the civil war, the protracted military government, and the economic development and current consolidation of democracy. In order to achieve this complex and ambitious narrative project, in El jinete polaco time is not represented as uninterrupted historical timeline but as the rich mixture of the simultaneous experiences of different life courses in terms of both values and cultural patterns in order to understand how the rapid social change affects relations between the various age groups. In other words, time is constructed as a synthesis of the biographical dimension within collective memory and major historical events. This paper seeks to point out the similarities and differences between biographical discourse, collective memory and history.

  5. Coping with chronic illness: the mediating role of biographic and illness-related factors.

    Science.gov (United States)

    Viney, L L; Westbrook, M T

    1982-01-01

    The aim of this research was to examine the mediating roles played by a range of biographic and illness-related factors in preferences for strategies for coping with chronic illness. Chronically-ill patients assessed their own coping strategy preference by ranking six clusters of strategies. Information was also obtained about their demographic characteristics, life styles, illness roles, the degree of their disability, their perceived handicaps and their perceived achievement of their rehabilitation goals. Multiple regression analyses of each of these six sets of variables on each coping strategy were carried out to identify patterns of association between them. (1) Preferences for action strategies were found to be associated with patient-related factors (demographic characteristics, life style and illness role). (2) Control strategies were associated with illness-related factors (illness role, degree of disability, perceived handicap and achievement of rehabilitation goals). (3) Escape strategies were ranked higher by women than by men, sex being their only significant predictor. (4) Preferences for fatalism, unlike those for action strategies, were associated with relatively low social status and relatively little interpersonal involvement or social commitment. (5) Preferences for optimism were related only to patients' perceptions of their handicaps. (6) Interpersonal coping was not found to be associated with any of this wide range of biographic illness-related factors.

  6. Biographical and demographical variables as moderators in the prediction of turnover intentions

    Directory of Open Access Journals (Sweden)

    Janine du Plooy

    2013-01-01

    Full Text Available Orientation: The aim of the study was to explore the possible moderation effects of biographical and demographical variables on a prediction model of turnover intention (TI.Research purpose: The main purpose of the study was to determine how biographical and demographical variables have an impact on predictors of turnover intentions.Motivation for the study: Twenty-first century organisations face significant challenges in the management of talent and human capital. One in particular is voluntary employee turnover and the lack of appropriate business models to track this process.Research design, approach, and method: A secondary data analysis (SDA was performed in a quantitative research tradition on the cross-sectional survey sample (n = 2429. Data were collected from a large South African Information and Communication Technologies (ICT sector company (N = 23 134.Main findings: The results of the study confirmed significant moderation effects regarding race, age, and marital status in the prediction equations of TIs.Practical and managerial implications: Practical implications of the study suggested increased understanding of workforce diversity effects within the human resource (HR value chain, with resultant evidence-based, employee retention strategies and interventions. Issues concerning talent management could also be addressed.Contribution and value-add: The study described in this article took Industrial/Organisational (I/O psychological concepts and linked them in unique combinations to establish better predictive validity of a more comprehensive turnover intentions model.

  7. "Maturing Out" and the Dynamics of the Biographical Trajectories of Hard Drug Addicts

    Directory of Open Access Journals (Sweden)

    Engel H. Prins

    2008-01-01

    Full Text Available This article by the late Engel H. PRINS is based on a qualitative research project (PRINS, 1995, which focuses on the biographical experiences of hard drug addicts in the Netherlands who presented, for the most part, a polydrug pattern of drug use that included mostly heroin, but also cocaine and other drugs. His project was inspired by the influential work of Charles WINICK (1962 who had proposed the hypothesis that a large number of addicts "mature out" of their addiction in the long run. While PRINS's project was partly an attempt to discover if this hypothesis could be held up in the Netherlands and particularly in Rotterdam, a major emphasis of his research was to reconstruct the biographical processes of the addicts and to understand the dynamics of their trajectories of suffering, including the processes of "maturing out" if they "kicked the habit." Therefore, he did 65 autobiographical narrative interviews with persons who were known to be addicted to hard drugs at least ten years before the interview. The analysis of this data was carried out according to procedures of biography analysis on the basis of autobiographical narrative interviews, which were developed by SCHÜTZE (1983, 2007a, b. The article presents a theoretical framework of the different phases of a drug addiction trajectory with a special emphasis on the process of "maturing out." URN: urn:nbn:de:0114-fqs0801303

  8. Ingested (oral) SIRS peptide 1-21 inhibits acute EAE by inducing Th2-like cytokines.

    Science.gov (United States)

    Brod, Staley A; Hood, Zachary

    2007-02-01

    Ingested type I IFN inhibits clinical attacks, relapses and inflammation in murine chronic relapsing EAE by inhibiting Th1-like cytokines. Type I IFN activates human suppressor T cells that produce SIRS. We examined whether oral (ingested) SIRS peptide inhibits EAE by decreasing Th1-like cytokines. Parenteral SIRS peptide 1-21 showed a significant inhibition of disease severity in murine EAE. Ingested SIRS peptide at 10 and 100 microg SIRS peptide showed a significant inhibition of disease severity but also a prolonged delay in the onset of disease compared to placebo. There were significantly less inflammatory foci in the SIRS peptide fed group compared to the control mock fed group. Splenocytes from SIRS peptide 1-21 fed mice showed increased production of Th2-like CD30L, IL-13, TCA-3 cytokines/chemokines and decreased production of Th1-like cytokine lymphotactin. Ingested (oral) SIRS peptide significantly inhibits both clinical EAE and inflammation predominately via counter-regulatory type 2-like cytokines/chemokines IL-13, CD30L and TCA-3.

  9. Stochastic regime switching SIR model driven by Lévy noise

    Science.gov (United States)

    Guo, Yingjia

    2017-08-01

    We propose a new stochastic regime switching SIR model driven by Lévy noise. A unique global positive solution is obtained under some appropriate conditions. Moreover, we investigate the asymptotic behavior of the stochastic SIR model with jumps under regime switching.

  10. Time from onset of SIRS to antibiotic administration and outcomes after subarachnoid hemorrhage.

    Science.gov (United States)

    Guterman, Elan L; Kamel, Hooman; Azran, Carmil; Shah, Maulik P; Claude Hemphill, J; Smith, Wade S; Navi, Babak B

    2014-08-01

    The interval from presentation with systemic inflammatory response syndrome (SIRS) to the start of antibiotic administration affects mortality in patients with sepsis. However, patients with subarachnoid hemorrhage (SAH) often develop SIRS directly from their brain injury, making it a less useful indicator of infection. We therefore hypothesized that SIRS would not be a suitable trigger for antibiotics in this population. We examined the time from the development of SIRS until antibiotic initiation and its relationship to long-term neurological outcomes in patients with nontraumatic SAH. Patients' baseline characteristics, time of antibiotic administration, and hospital course were collected from retrospective chart review. The primary outcome, 6-month functional status, was prospectively determined using blinded, structured interviews incorporating the modified Rankin Scale (mRS). Sixty-six of 70 patients with SAH during the study period had 6-month follow-up and were included in this analysis. SIRS developed in 57 patients (86%, 95% CI 78-95%). In ordinal logistic regression models controlling for age and illness severity, the time from SIRS onset until antibiotic initiation was not associated with 6-month mRS scores (OR per hour, 0.994; 95% CI 0.987-1.001). In this cohort of patients with SAH, time from SIRS onset until antibiotic administration was not related to functional outcomes. Our results indicate that SIRS is nonspecific in patients with SAH, and support the safety of withholding antibiotics in those who lack additional evidence of infection or hemodynamic deterioration.

  11. [SIRS and CARS: discussion based on the pathologic condition of acute pancreatitis].

    Science.gov (United States)

    Hirota, M; Nozawa, F; Okabe, A; Shibata, M; Kuwata, K; Ogawa, M

    2000-06-01

    Relationship between SIRS and CARS in the pathologic condition of acute pancreatitis was discussed. SIRS promotes excessive inflammatory reaction and CARS induces the susceptibility to infection. Both conditions can develop into organ failure in acute pancreatitis. Hence, countermeasures for both conditions are mandatory in the care of patients with acute pancreatitis.

  12. Author Details

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH. AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING AJOL · RESOURCES. Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads.

  13. Author Details

    African Journals Online (AJOL)

    Patriarchal Women's Spirituality Details · Vol 15, No 1 (2002): - Articles The suffering mothers – The Hindu Amman Goddesses as Empowering Role Models for Women Details · Vol 18, No 1 (2005): - Articles South Indian and Spanish Virgins: ...

  14. Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

    Science.gov (United States)

    Caserta, Stefano; Kern, Florian; Cohen, Jonathan; Drage, Stephen; Newbury, Sarah F; Llewelyn, Martin J

    2016-06-20

    Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-infective SIRS. Critically ill patients with severe (n = 21) or non-severe (n = 8) intra-abdominal sepsis; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied. Next-generation sequencing and qRT-PCR were used to measure plasma microRNAs. Detectable blood miRNAs (n = 116) were generally up-regulated in SIRS compared to no-SIRS patients. Levels of these 'circulating inflammation-related microRNAs' (CIR-miRNAs) were 2.64 (IQR: 2.10-3.29) and 1.52 (IQR: 1.15-1.92) fold higher for non-infective SIRS and sepsis respectively (p SIRS. Six CIR-miRNAs (miR-30d-5p, miR-30a-5p, miR-192-5p, miR-26a-5p, miR-23a-5p, miR-191-5p) provided good-to-excellent discrimination of severe sepsis from severe SIRS (0.742-0.917 AUC of ROC curves). CIR-miRNA levels inversely correlated with pro-inflammatory cytokines (IL-1, IL-6 and others). Thus, among critically ill patients, sepsis and non-infective SIRS are associated with substantial, differential changes in CIR-miRNAs. CIR-miRNAs may be regulators of inflammation and warrant thorough evaluation as diagnostic and therapeutic targets.

  15. Sir Francis Walshe, MD FRS (1885-1973).

    Science.gov (United States)

    Pearce, J M S

    2006-05-01

    Born in Ireland, Francis Martin Rouse Walshe studied medicine at University College Hospital. He subsequently practised there and at the National Hospital, Queen Square, London. Early associations with Wilfred Trotter and Sir Victor Horsley encouraged his career in Neurology. Walshe pioneered the descriptive analysis of human reflexes in physiological terms. His flare and outstanding brilliance were rewarded when he was appointed Physician to the National Hospital, Queen Square in 1921 and at University College Hospital in 1924. He published, mainly in Brain (which he edited for many years), weighty papers on the function of the cerebral cortex in relation to movements, and on neural physiology. Walshe is also remembered for his powers of literacy and stringent scientific criticism, which he often displayed with magnificent panache.

  16. Sir Archibald Garrod and alkaptonuria -'story of metabolic genetics'.

    Science.gov (United States)

    Prasad, C; Galbraith, P A

    2005-09-01

    Clinical disorders have intrigued the human mind for thousands of years. Many are enshrined in history as 'medical curiosities'. This report is a tribute to one of the greatest minds of modern genetics and medicine, Sir Archibald Edward Garrod (1857--1936), who brought forward the scientific study of inborn errors of metabolism. Garrod's concept of 'chemical individuality' with no awareness of 'genes' more than 100 years ago is an amazing example of futuristic thinking. His own words reflect this, 'Owing, as I believe, to their chemical individuality different human beings differ widely in their liability to individual maladies, and to some extent in the signs and symptoms which they exhibit'. The concept of chemical individuality is here to stay. Garrod has also provided insight into a number of scientific concepts and modern thinking.

  17. [Cytokine imbalance in critically ill patients: SIRS and CARS].

    Science.gov (United States)

    Murata, A; Kikuchi, M; Mishima, S; Sakaki, S; Goto, H; Matsuoka, T; Tanaka, H; Yukioka, T; Shimazaki, S

    1999-07-01

    It remains difficult to treat severely ill patients, especially those who have sepsis and subsequent multiple organ dysfunction syndrome. We propose the hypothesis that the pathophysiology in the sequential sepsis and multiple organ dysfunction syndrome may be strongly related to the imbalance between inflammatory cytokines and antiinflammatory cytokines induced for the host defense to active neutrophils and endothelial cells. Thus we attempted to develop cytokine modulation therapy to normalize the cytokine balance in the host defense system. In this review, we elucidate the relationship between cytokine imbalance and SIRS/CARS in patients with severe burn injury. Furthermore, we examine the possible usage of G-CSF to amplify neutrophil function, and clarify the reasons why various innovative therapies against sepsis have failed.

  18. Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

    Directory of Open Access Journals (Sweden)

    R. K. Maharjan

    2012-09-01

    Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

  19. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    Science.gov (United States)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  20. Author Details

    African Journals Online (AJOL)

    Details PDF · Vol 22, No 2 (1999) - Articles Vegetation under different tree species in Acacia woodland in the Rift Valley of Ethiopia Details PDF · Vol 22, No 2 (1999) - Articles Preliminary evaluation of Phytomyza orobanchia (Diptera: Agromyzidae) as a controller of Orobanche spp in Ethiopia Details PDF. ISSN: 2520–7997.

  1. Author Details

    African Journals Online (AJOL)

    Details · Vol 1, No 1 (2003) - Articles Mesalazine: the gold standard for maintenance therapy in inflammatory bowel disease: review. Details · Vol 1, No 1 (2003) - Articles The dangers of eating away from home: review. Details · Vol 1, No 1 (2003) - Articles Infliximab (Revellex) inflammatory bowel disease: guidelines

  2. SIR (Safe Integral Reactor) - reducing size can reduce cost

    International Nuclear Information System (INIS)

    Hayns, M.R.

    1991-01-01

    Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

  3. Biographical Sources in the Sciences--Life, Earth and Physical Sciences (1989-2006). LC Science Tracer Bullet. TB 06-4

    Science.gov (United States)

    Freitag, Ruth, Comp.; Bradley, Michelle Cadoree, Comp.

    2006-01-01

    This guide offers a systematic approach to the wide variety of published biographical information on men and women of science in the life, earth and physical sciences, primarily from 1989 to 2006, and complements Library of Congress Science Tracer Bullet "TB88-3" ("Biographical Sources in the Sciences," compiled 1988 [ED306074]) and "TB06-7"…

  4. Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu-Sir4 interaction.

    Science.gov (United States)

    Guintini, Laetitia; Tremblay, Maxime; Toussaint, Martin; D'Amours, Annie; Wellinger, Ralf E; Wellinger, Raymund J; Conconi, Antonio

    2017-05-05

    Ultraviolet light (UV) causes DNA damage that is removed by nucleotide excision repair (NER). UV-induced DNA lesions must be recognized and repaired in nucleosomal DNA, higher order structures of chromatin and within different nuclear sub-compartments. Telomeric DNA is made of short tandem repeats located at the ends of chromosomes and their maintenance is critical to prevent genome instability. In Saccharomyces cerevisiae the chromatin structure of natural telomeres is distinctive and contingent to telomeric DNA sequences. Namely, nucleosomes and Sir proteins form the heterochromatin like structure of X-type telomeres, whereas a more open conformation is present at Y'-type telomeres. It is proposed that there are no nucleosomes on the most distal telomeric repeat DNA, which is bound by a complex of proteins and folded into higher order structure. How these structures affect NER is poorly understood. Our data indicate that the X-type, but not the Y'-type, sub-telomeric chromatin modulates NER, a consequence of Sir protein-dependent nucleosome stability. The telomere terminal complex also prevents NER, however, this effect is largely dependent on the yKu-Sir4 interaction, but Sir2 and Sir3 independent. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  5. Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

    Science.gov (United States)

    2005-01-01

    Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

  6. Towards establishing biographical and business background profiles of entrepreneurs from two ethnic and gender groups

    Directory of Open Access Journals (Sweden)

    J. L. Schutte

    1995-06-01

    Full Text Available The literature on the biographical backgrounds of entrepreneurs seems to contain many contradictory findings. This situation can partly be due to the assumption that samples of entrepreneurs were homogeneous rather than heterogeneous. It appears as if female entrepreneurs have been less well researched than their male counterparts. Differences in the biographical backgrounds and business situation of, respectively, the white and the black entrepreneurs in South Africa have been assumed but little empirical evidence exists in this respect. Black en-trepreneurs, and female entrepreneurs are in most developed societies' minority groups and have not specifically been studied in depth - hence the present study. The biographical and business backgrounds of 569 South African entrepreneurs (106 Black and 463 White; 136 female and 433 male were studied. One-way Analyses of Variance and Chi-squared followed by Discriminant analyses were carried out to determine whether, respectively, black and white entrepreneurs and male and female entrepreneurs differed in terms of the variables studied. Significant differences between the total group of male and female subjects were found on only five variables. White and black entrepreneurs differed statistically significantly on 16 of the 30 variables studied. Opsomming Die literatuur oor die biografiese agtergronde van entrepreneurs skyn baie teenstrydige bevindinge te bevat. Hierdie kan moontlik deels toegeskryf word aan die aanname dat steekproewe van entrepreneurs eerder homogeen eerder as heterogeen is. Dit skyn asof minder navorsing oor vroulike as oor manlike entrepreneurs gedoen is. Ten spyte van aannames in die verband, bestaan min empiriese gegewens oor die biografiese agtergronde en sake-situasie van respektiewelik wit en swart Suid-Afrikaanse entrepreneurs. Swart en vroulike entrepreneurs is in meeste gemeenskappe minderheidsgroepe en is nog nie in diepte bestudeer nie, daarom die huidige studie. Die

  7. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

    Science.gov (United States)

    Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

    2004-02-01

    The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

  8. Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.

    Science.gov (United States)

    Stoppelkamp, Sandra; Veseli, Kujtim; Stang, Katharina; Schlensak, Christian; Wendel, Hans Peter; Walker, Tobias

    2015-01-01

    Systemic inflammatory response syndrome (SIRS) is a common complication after cardiovascular surgery that in severe cases can lead to multiple organ dysfunction syndrome and even death. We therefore set out to identify reliable early biomarkers for SIRS in a prospective small patient study for timely intervention. 21 Patients scheduled for planned cardiovascular surgery were recruited in the study, monitored for signs of SIRS and blood samples were taken to investigate biomarkers at pre-assigned time points: day of admission, start of surgery, end of surgery, days 1, 2, 3, 5 and 8 post surgery. Stored plasma and cryopreserved blood samples were analyzed for cytokine expression (IL1β, IL2, IL6, IL8, IL10, TNFα, IFNγ), other pro-inflammatory markers (sCD163, sTREM-1, ESM-1) and response to endotoxin. Acute phase proteins CRP, PCT and pro-inflammatory cytokines IL6 and IL8 were significantly increased (pSIRS group at the end of surgery. Soluble TREM-1 plasma concentrations were significantly increased in patients with SIRS (pSIRS after cardiovascular surgery. A combination of normalized IL1β plasma levels, responses to endotoxin and soluble TREM-1 plasma concentrations at the end of surgery are predictive markers of SIRS development in this small scale study and could act as an indicator for starting early therapeutic interventions.

  9. Application of SIRS criteria to a paediatric surgical population in Malawi.

    Science.gov (United States)

    Samuel, Jonathan C; Varela, Carlos; Cairns, Bruce A; Charles, Anthony G

    2014-08-01

    Little is known regarding systemic inflammatory response syndrome (SIRS) criteria and mortality in developing countries. We evaluated the utility of the SIRS criteria to predict death among a paediatric surgical population in Lilongwe, Malawi. Age, SIRS variables (temperature, heart rate, systolic blood pressure, respiratory rate and leucocyte count), diagnosis, surgical procedure and outcome were analysed for paediatric surgical patients during 2012. Age-specific criteria for SIRS variables were then applied to the data. Using published SIRS criteria, temperature was the only variable that correlated with mortality. When norms for an African population were used, leucocyte count also correlated with mortality. With the exception of temperature, published SIRS criteria were not predictive of mortality. Leucocyte count became predictive of death using norms specific to an African population. SIRS and its component data are a worthwhile area of future prospective research in developing countries. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS.

    Science.gov (United States)

    Oku, Reiko; Oda, Shigeto; Nakada, Taka-aki; Sadahiro, Tomohito; Nakamura, Masataka; Hirayama, Yoh; Abe, Ryuzo; Tateishi, Yoshihisa; Ito, Michihiro; Iseki, Toru; Hirasawa, Hiroyuki

    2013-01-01

    Triggering receptor expressed on myeloid cells-1 (TREM-1) was reported to play a key roll in amplification of production of inflammatory cytokines. TREM-1 is suggested to be a specific biomarker for sepsis for this reason, but the clinical significance of TREM-1 has not been elucidated. We investigated TREM-1 expression on the cell-surface, and plasma levels of soluble TREM-1 (sTREM-1) in patients with non-infectious systemic inflammatory response syndrome (SIRS) and sepsis admitted to the ICU. Thirty-five patients with SIRS and 21 patients with sepsis admitted to ICU were subjected to the study. TREM-1 expressions on the surfaces of monocytes and neutrophils were measured by flow cytometry. Plasma sTREM-1 level and serum interleukin (IL)-6 level were measured. Septic patients had decreased TREM-1 expression, clearly on neutrophils or to a lesser extent on monocyte compared to SIRS patients on ICU admission (neutrophils pSIRS patients (pSIRS/sepsis patients (pSIRS patients. sTREM-1 may be useful to evaluate disease severity and outcome of patients with SIRS or sepsis. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. The Participants' Perspective: How Biographic-Narrative Intervention Influences Identity Negotiation and Quality of Life in Aphasia

    Science.gov (United States)

    Corsten, Sabine; Schimpf, Erika J.; Konradi, Jürgen; Keilmann, Annerose; Hardering, Friedericke

    2015-01-01

    Background: People with aphasia experience a pronounced decrease in quality of life (QoL). Beyond that identity negotiation is hindered, which is crucial for QoL. Biographic-narrative approaches use life story telling to support identity (re)development after disruptive events like stroke. Because of the language deficits inherent in aphasia such…

  12. 76 FR 10421 - 60-Day Notice of Proposed Information Collection: DS-5513, Biographical Questionnaire for U.S...

    Science.gov (United States)

    2011-02-24

    ... Project Management and Operational Support, Workforce Management (CA/PPT/PMO/WM) Form Number: DS-5513... of Management and Budget (OMB) approval for the information collection described below. The purpose... Information Collection: Biographical Questionnaire for U.S. Passport. OMB Control Number: None. Type of...

  13. Autobiographical reasoning in life narratives buffers the effect of biographical disruptions on the sense of self-continuity.

    Science.gov (United States)

    Habermas, Tilmann; Köber, Christin

    2015-01-01

    Personal identity depends on synchronic coherence and diachronic continuity of the self. Autobiographical remembering and autobiographical knowledge as well as the stability of bodily integrity, of social roles, of significant others and of physical and sociocultural environment have been suggested as supporting a pre-reflective sense of self-continuity. Stark biographical discontinuities or disruptions in these areas may destabilise the sense of self-continuity. To test the hypothesis that autobiographical reasoning in life narratives helps to compensate the effects of biographical discontinuities on the sense of self-continuity, life narratives of a lifespan sample with the ages of 16, 20, 24, 28, 44 and 69 (N = 150, 78 female) were investigated. Results confirm that if, and only if there have been biographical disruptions in the past four years, then autobiographical reasoning correlates positively with a sense of self-continuity. The findings contradict the thesis that mere remembering of past episodes is sufficient to maintain a sense of self-continuity under conditions of biographical change.

  14. Constructions of Taiwanese/Chinese Asian American Women Teacher Identities: A Complicated and Complicating Auto/Biographical Study

    Science.gov (United States)

    Chen, Tan-ching

    2009-01-01

    Conducted as an auto/biographical and narrative qualitative research study, this dissertation traces the researcher's winding journey in search of her teacher identities, whose cultural and discursive meanings are always changing. There are two subjects in this study--the researcher's colleague as her research participant and the researcher…

  15. Transformative Learning and the Form That Transforms: Towards a Psychosocial Theory of Recognition Using Auto/ Biographical Narrative Research

    Science.gov (United States)

    West, Linden

    2014-01-01

    In this article, I interrogate the changing forms that may be fundamental to transformative learning and how these are best chronicled and understood. Drawing on auto/biographical narrative research, I challenge the continuing primacy of a kind of overly disembodied, decontextualized cognition as the basis of transformation. Notions of epistemic…

  16. How does biographic-narrative intervention influence identity negotiation and quality of life in aphasia? - The participants' perspective

    Directory of Open Access Journals (Sweden)

    Jürgen Konradi

    2014-04-01

    The quantitative and the qualitative results were complementary in demonstrating the effectiveness of the biographic-narrative intervention. As predicted, there was a specific treatment effect with a significant and stable improvement in QoL. Analysis of the semi-structured interviews indicated that through the approach the participants’ sense of self changed. The findings provide foundations for future work into intervention.

  17. Experimental "microcultures" in young children: identifying biographic, cognitive, and social predictors of information transmission.

    Science.gov (United States)

    Flynn, Emma; Whiten, Andrew

    2012-01-01

    In one of the first open diffusion experiments with young children, a tool-use task that afforded multiple methods to extract an enclosed reward and a child model habitually using one of these methods were introduced into different playgroups. Eighty-eight children, ranging in age from 2 years 8 months to 4 years 5 months, participated. Measures were taken of how alternative methods and success in extracting rewards spread across the different groups. Additionally, the biographic, social, cognitive, and temperamental predictors of social learning were investigated. Variations in social learning were related to age, popularity, dominance, impulsivity, and shyness, while other factors such as sex, theory of mind, verbal ability, and even imitativeness showed little association with variance in children's information acquisition. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

  18. Biographical learning in top-level coaching - personal styles and the power of practical sense

    DEFF Research Database (Denmark)

    Christensen, Mette Krogh

    aspects of coaching expertise: 1) the coaches’ descriptions of their development of expertise as a “personal journey” and a matter of unique pathways, and 2) the coaches’ use of social constructed practical sense in their daily work, particularly in identification and assessment of skillfulness and talent......Abstract for “Sports and Coaching – Past and Futures” MMU Institute for Performance Research, 25/26 June 2011 Author: Christensen, Mette Krogh Associate Professor, Ph.D. Institute of Sports Science and Clinical Biomechanics University of Southern Denmark Campusvej 55, 5230 Odense M, Denmark Title......: Biographical learning in top-level coaching - personal styles and the power of practical sense. There is a growing body of studies in sports coaching cultures, comprising research focusing on the individual learning processes and life histories of top-level coaches. Even if top-level sport has become...

  19. Biographical Narratives of Encounter: The Significance of Mobility and Emplacement in Shaping Attitudes towards Difference

    Science.gov (United States)

    Sadgrove, Joanna

    2014-01-01

    This paper is located within work in urban studies about the significance of contact with difference as a means for reducing prejudice and achieving social change. Recent approaches, influenced by theories of affect, have emphasised non-conscious everyday negotiations of difference in the city. In this paper it is argued that such approaches lose sight of the significance of the subject: of the reflective judgements of ‘others’ made by individuals; of our ability to make decisions around the control of our feelings and identifications; and of the significance of personal pasts and collective histories in shaping the ways we perceive and react to encounters. Rather, this paper uses a biographical approach focusing on interviewees’ narratives of encounter. Through its attention to processes of mobility and emplacement, it contributes to debates about when contact with difference matters by highlighting the importance of everyday social normativities in the production of moral dispositions. PMID:26300566

  20. Biographical narrative in relation to Great History : Les éblouissements by Pierre Mertens

    Directory of Open Access Journals (Sweden)

    Jerzy Lis

    2012-01-01

    Full Text Available Pierre Mertens’ novel Les éblouissements, published in 1987, is a fictionalised biography of a famous German poet Gottfried Benn, who made the biggest mistake of his life agreeing to support the National Socialist regime during several months. Mertens reconstructs the poet’s life trying to understand the reasons of his commitment, considered by the intellectuals of that time to be a betrayal. Mertens’ text is an illustration of the relationship between the individual and the historical past and, at the same time, an example of problemising the biographical factor in relation to Great History. Playing with the double signification of the word ‘éblouissement’, the novelist offers his own interpretation of the German poet’s double life.

  1. "I Will Never Become a Soldier for You!": The Relevance of Biographical Learning for Political Action

    Directory of Open Access Journals (Sweden)

    Andrea Neugebauer

    2011-05-01

    Full Text Available This article focuses on the biographical dimension of the processes of developing political awareness and the significance for consistency in political action. It is based on a single case study which was developed within an oral history project in the 1980s. A new reconstruction of a worker's narrative about his refusal to serve in the army and subsequent flight during the National-Socialist period shows how personal desires for change and institutionalized political patterns of interpretation and action are intertwined. The protagonist could cope with times of extremely restricted latitude for action, as was the case in the Nazi era, acquiring personal learning or crisis management skills as long as there was hope for future emancipation and social integration. In the postwar period the dissipation of this perspective lead to a reduction in his individual ability to take political action. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1102118

  2. Nonorganic hearing loss in children: audiometry, clinical characteristics, biographical history and recovery of hearing thresholds.

    Science.gov (United States)

    Schmidt, Claus-Michael; am Zehnhoff-Dinnesen, Antoinette; Matulat, Peter; Knief, Arne; Rosslau, Ken; Deuster, Dirk

    2013-07-01

    The term "nonorganic hearing loss" (NOHL) (pseudohypacusis, functional or psychogenic hearing loss) describes a hearing loss without a detectable corresponding pathology in the auditory system. It is characterized by a discrepancy between elevated pure tone audiometry thresholds and normal speech discrimination. The recommended audiological management of NOHL in children comprises history taking, diagnosis, and counseling. According to the literature, prognosis depends on the severity of the patient's school and/or personal problems. Routine referral to a child psychiatrist is discussed as being controversial. The clinical history of 34 children with NOHL was retrospectively evaluated. In 15 children, follow up audiometry was performed. Results of biographical history, subjective and objective audiometry, additional speech and language assessment, psychological investigations and follow up audiometry are presented and discussed. The prevalence of NOHL was 1.8% in children with suspected hearing loss. Mean age at diagnosis was 10.8 years. Girls were twice as often affected as boys. Patient history showed a high prevalence of emotional and school problems. Pre-existing organic hearing loss can be worsened by nonorganic causes. Children with a fast recovery of hearing thresholds (n=6) showed a high rate (4/6) of family, social and emotional problems. In children with continuous threshold elevation (n=9), biographical history showed no recognizable or obvious family, social or emotional problems; learning disability (4/9) was the most frequently presented characteristic. Due to advances in objective audiometry, the diagnosis of NOHL is less challenging than management and counseling. Considering the high frequency of personal and school problems, a multidisciplinary setting is helpful. On the basis of our results, drawing conclusions from hearing threshold recovery on the severity of underlying psychic problems seems inappropriate. As a consequence, a referral to a

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    An Overview of Africa's Marine Resources: Their Utilization and Sustainable Management Details · Vol 12, No 3 (2000) - Articles EDITORIAL Ganoderma Lucidum - Paramount among Medicinal Mushrooms. Details · Vol 15, No 3 (2003) - Articles Editorial: Africa's Mushrooms: A neglected bioresource whose time has come

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    Tropical anaesthesia: effect on rehabilitation of spasticity in hemiplegic patients. Details · Vol 10, No 4 (2000) - Articles The effect of low intensity therapeutic ultrasound on fibroblast proliferation during the early stages of tendon healing. Details · Vol 18, No 2 (2008) - Articles Factors contributing to possession of walking aids ...

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    Cariem, AK. Vol 1, No 2 (2003) - Articles Gastric outlet obstruction caused by drug-induced focal pancreatitis: case report. Details · Vol 2, No 2 (2004) - Articles Current management of chronic hepatitis B: review. Details. ISSN: 1812-1659. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

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    Details PDF · Vol 2, No 3 (2002) - Articles Oxydation Catalytique du Butane en Anhydride Maleique par les Oxides V-P. Details PDF · Vol 3, No 3 (2003) - Articles Caracterisation physico-chimique des fruits de quatre essences locales : vitex doniana sweet, vitex madiensis oliv. olax subscorpioides oliv. et ximenia americana

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 45 (2016) - Articles From vectors to waves and streams: An alternative approach to semantic maps1. Abstract PDF · Vol 48 (2017) - Articles Introduction: 'n Klein ietsie for Johan Oosthuizen

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    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... to blast loadings. Abstract PDF · Vol 9, No 3S (2017): Special Issue - Articles Experimental and numerical investigation on blast wave propagation in soil structure. Abstract PDF. ISSN: 1112-9867.

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... The use of negative pressure wave treatment in athlete recovery. Abstract PDF · Vol 29, No 1 (2017) - Articles The prevalence, risk factors predicting injury and the severity of injuries sustained during ...

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    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 29, No 1 (2017) - Articles The use of negative pressure wave treatment in athlete recovery. Abstract PDF · Vol 29, No 1 (2017) - Articles The prevalence, risk factors predicting injury and the ...

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    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Uptake of intermittent preventive therapy in pregnancy for malaria in Zimbabwe 2013-2015 Audit Abstract. ISSN: 0008-9176. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for ...

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    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Regional Anaesthetic Blocks For Hand Surgery In Resource Limited Areas Abstract PDF · Vol 9 (2012) - Articles Audit of prophylactic antibiotic use in orthopaedic surgery in Mulago Hospital

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    African Journals Online (AJOL)

    Garisch, J. Vol 1, No 1 (2003) - Articles Infliximab (Revellex) inflammatory bowel disease: guidelines. Details · Vol 1, No 2 (2003) - Articles Reflux disease: pathways to the best care: guidelines. Details. ISSN: 1812-1659. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

  13. Italian Society of Rheumatology (SIR recommendations for performing arthrocentesis

    Directory of Open Access Journals (Sweden)

    A. Spadaro

    2011-09-01

    Full Text Available Joint fluid aspiration, or arthrocentesis, is one of the most useful and commonly performed procedures for the diagnosis and treatment of rheumatic diseases, but to date no definite guidelines have been published. For this reason, a group of experts of the Italian Society of Rheumatology (SIR produced evidence based recommendations for performing arthrocentesis. Among them, the most relevant are: a arthrocentesis is necessary when synovial effusion of unknown origin is present, especially if septic or crystal arthritis is suspected; b the patient should be clearly informed of the benefits and risks of the procedure in order to give an informed consent; c ultrasonography should be used to facilitate arthrocentesis in difficult joints; d fluid evacuation often has a therapeutic effect and facilitates the success of the following intraarticular injection; e careful skin disinfection and the use of sterile, disposable material is mandatory for avoiding septic complications. Disposable, non sterile gloves should always be used by the operator, mainly for his own protection; f contraindications are the presence of skin lesions or infections in the area of the puncture; g the patient’s anticoagulant treatment is not a contraindication, providing the therapeutic range is not exceeded; h joint rest after arthrocentesis is not indicated. Several of these recommendations were based on experts’ opinion rather than on published evidence which is scanty.

  14. Sir James Young Simpson and religion: myths and controversies.

    Science.gov (United States)

    Cameron, Ewen A; MacGillivray, Neil

    2013-02-01

    This paper analyses two key aspects of the life and work of Sir James Young Simpson: his evangelical Christianity and his reaction to criticism following his use of anaesthesia in obstetrics. Simpson's personal religious struggle is placed in the context of the devastating events surrounding the Disruption of the established Church of Scotland in 1843. Whatever his involvement in the events of that year, the development of his faith demonstrates his simple evangelical conviction in the atonement of Christ, very much in keeping with that of many believers in Victorian Britain. There has arisen the notion (still current as is clear from publications in medical journals within recent years) that there was a savage religious response, especially in Presbyterian Scotland, to his use of chloroform - in reality the attack on Simpson's enthusiastic promotion of chloroform was brief, sporadic and of little moment. Simpson's carefully constructed counter to criticism of anaesthesia, drawing on considerable theological and linguistic expertise, reveals a complexity at odds with the simplicity of his faith. The contrast is so great and the reaction so elaborate that it is proposed that Simpson deliberately exaggerated the affair, believing the publicity could only be valuable.

  15. The independent spreaders involved SIR Rumor model in complex networks

    Science.gov (United States)

    Qian, Zhen; Tang, Shaoting; Zhang, Xiao; Zheng, Zhiming

    2015-07-01

    Recent studies of rumor or information diffusion process in complex networks show that in contrast to traditional comprehension, individuals who participate in rumor spreading within one network do not always get the rumor from their neighbors. They can obtain the rumor from different sources like online social networks and then publish it on their personal sites. In our paper, we discuss this phenomenon in complex networks by adopting the concept of independent spreaders. Rather than getting the rumor from neighbors, independent spreaders learn it from other channels. We further develop the classic "ignorant-spreaders-stiflers" or SIR model of rumor diffusion process in complex networks. A steady-state analysis is conducted to investigate the final spectrum of the rumor spreading under various spreading rate, stifling rate, density of independent spreaders and average degree of the network. Results show that independent spreaders effectively enhance the rumor diffusion process, by delivering the rumor to regions far away from the current rumor infected regions. And though the rumor spreading process in SF networks is faster than that in ER networks, the final size of rumor spreading in ER networks is larger than that in SF networks.

  16. Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol.

    Science.gov (United States)

    Lee, Jiyun; Kwon, Gayeung; Park, Jieun; Kim, Jeong-Keun; Lim, Young-Hee

    2016-10-01

    Resveratrol (RES) has been studied for its effects on the lifespan extension of Caenorhabditis elegans, but controversy still remains on its mechanism related with SIR-2. In this study, longevity assay was performed to confirm SIR-2-dependent lifespan extension of C. elgeans with RES and oxyresveratrol (OXY), an isomer of hydroxylated RES using loss-of-function mutants of C. elegans including sir-2.1 mutant. The results showed that OXY and RES significantly (P elegans compared with the control. OXY and RES also significantly (P elegans by overexpression of SIR-2.1, which is related to lifespan extension through calorie restriction and the AMP-activated protein kinase (AMPK) pathway, although this process is independent of the FOXO/DAF-16 pathway. © 2016 by the Society for Experimental Biology and Medicine.

  17. Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

  18. Author Details

    African Journals Online (AJOL)

    chimique des fruits de quatre essences locales : vitex doniana sweet, vitex madiensis oliv. olax subscorpioides oliv. et ximenia americana. Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

  19. SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

    OpenAIRE

    Beddington, Sir John

    2012-01-01

    The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

  20. Use of the SIRS in compensation cases: an examination of its validity and generalizability.

    Science.gov (United States)

    Rogers, Richard; Payne, Joshua W; Berry, David T R; Granacher, Robert P

    2009-06-01

    The Structured Interview of Reported Symptoms (SIRS; Rogers et al., Structured interview of reported symptoms (SIRS) and professional manual, 1992) is a well-validated psychological measure for the assessment of feigned mental disorders (FMD) in clinical, forensic, and correctional settings. Comparatively little work has evaluated its usefulness in compensation and disability contexts. The present study examined SIRS data from 569 individuals undergoing forensic neuropsychiatric examinations for the purposes of workers' compensation, personal injury, or disability proceedings. Using bootstrapping comparisons, three primary groups were identified: FMD, feigned cognitive impairment (FCI), genuine-both (GEN-Both) that encompasses both genuine disorders (GEN-D) and genuine-cognitive presentation (GEN-C). Consistent with the SIRS main objective, very large effect sizes (M Cohen's d = 1.94) were observed between FMD and GEN-Both groups. Although not intended for this purpose, moderate to large effect sizes (M d = 1.13) were found between FCI and GEN-Both groups. An important consideration is whether SIRS results are unduly affected by common diagnoses or clinical conditions. Systematic comparisons were performed based on common disorders (major depressive disorder, PTSD, and other anxiety disorders), presence of a cognitive disorder (dementia, amnestic disorder, or cognitive disorder NOS), or intellectual deficits (FSIQ SIRS primary scales was small and nonsignificant, providing evidence of the SIRS generalizability across these diagnostic categories. Finally, the usefulness of the SIRS improbable failure-revised (IF-R) scale was tested as a FCI screen. Although it has potential in ruling out genuine cases, the IF-R should not be used as a feigning screen.

  1. SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.

    Science.gov (United States)

    Ogura, Hiroshi; Gando, Satoshi; Iba, Toshiaki; Eguchi, Yutaka; Ohtomo, Yasuhiro; Okamoto, Kohji; Koseki, Kazuhide; Mayumi, Toshihiko; Murata, Atsuo; Ikeda, Toshiaki; Ishikura, Hiroyasu; Ueyama, Masashi; Kushimoto, Shigeki; Saitoh, Daizoh; Endo, Shigeatsu; Shimazaki, Shuji

    2007-10-01

    Coagulopathy and thrombocytopenia often occur in critically ill patients, and disseminated intravascular coagulation (DIC) can lead to multiple organ dysfunction and a poor outcome. However, the relation between coagulopathy and systemic inflammatory response has not been thoroughly clarified. Thus, we evaluated coagulative activity, organ dysfunction, and systemic inflammatory response syndrome (SIRS) in critically ill patients with thrombocytopenia and examined the balance between coagulopathy and systemic inflammation. Two hundred seventy-three patients, who were admitted to 13 critical care centers in Japan and fulfilled the criteria of platelet count of less than 150*10(9)/L, were included. Coagulative variables (platelet count, fibrin/fibrinogen degradation products, and DIC scores), organ dysfunction index (Sequential Organ Failure Assessment [SOFA] score), and SIRS score in each patient were evaluated for 4 consecutive days after fulfilling the above entry criteria. The effect of SIRS on coagulopathy and organ dysfunction was evaluated in these patients. Both the maximum SIRS score and entry SIRS score had significant relation to the maximum SOFA score during the observation period. Coagulation disorders indicated by the minimum platelet count, maximum DIC scores, and positivity for DIC worsened gradually with increases in SIRS scores. Both the minimum platelet count and maximum DIC scores were significantly correlated with the maximum SOFA score, indicating that a relation exists between coagulopathy and organ dysfunction. In critically ill patients with thrombocytopenia, coagulopathy and organ dysfunction progress with significant mutual correlation, depending on the increase in SIRS scores. The SIRS-associated coagulopathy may play a critical role in inducing organ dysfunction after severe insult.

  2. Author Details

    African Journals Online (AJOL)

    Libouga, David Gabriel. Vol 1, No 1 (2001) - Articles Etudes du lait de Zebu (Bos Indicus) obtenu à Ngaoundéré (Adamaoua, Nord Cameroun Details PDF · Vol 2, No 2 (2002) - Articles Extrait des ecorces de l'ongokea gore: protéolysé et conservation. Details PDF · Vol 3, No 3 (2003) - Articles Quelques caractéristiques ...

  3. Adenosine A2A receptor hyperexpression in patients with severe SIRS after cardiopulmonary bypass.

    Science.gov (United States)

    Kerbaul, François; Bénard, Frédéric; Giorgi, Roch; Youlet, By; Carrega, Louis; Zouher, Ibrahim; Mercier, Laurence; Gérolami, Victoria; Bénas, Vincent; Blayac, Dorothée; Gariboldi, Vlad; Collart, Frédéric; Guieu, Régis

    2008-08-01

    Adenosine (ADO) is an endogenous nucleoside, which has been involved in blood pressure failure during severe systemic inflammatory response syndrome (severe SIRS) after cardiac surgery with cardiopulmonary bypass (CPB). Adenosine acts via its receptor subtypes, namely A1, A2A, A2B, or A3. Because A2A receptors are implicated in vascular tone, their expression might contribute to severe SIRS. We compared adenosine plasma levels (APLs) and A2A ADO receptor expression (ie, B, K, and mRNA amount) in patients with or without postoperative SIRS. : This was a prospective comparative observational study. Forty-four patients who underwent cardiac surgery involving CPB. Ten healthy subjects served as controls. Among the patients, 11 presented operative vasoplegia and postoperative SIRS (named complicated patients) and 33 were without vasoplegia or SIRS (named uncomplicated patients). Adenosine plasma levels, K, B, and mRNA amount (mean +/- SD) were measured on peripheral blood mononuclear cells. Adenosine plasma levels, B, and K were significantly higher in complicated patients than in uncomplicated patients (APLs: 2.7 +/- 1.0 vs 1.0 +/- 0.5 micromol l, P SIRS after CPB.

  4. Systemic inflammatory response syndrome (SIRS) after extracorporeal membrane oxygenation (ECMO): Incidence, risks and survivals.

    Science.gov (United States)

    Thangappan, Karthik; Cavarocchi, Nicholas C; Baram, Michael; Thoma, Brandi; Hirose, Hitoshi

    2016-01-01

    Systemic inflammatory response syndrome (SIRS) is frequently observed after extracorporeal membrane oxygenation (ECMO) decannulation; however, these issues have not been investigated well in the past. Retrospective chart review was performed to identify post-ECMO SIRS phenomenon, defined by exhibiting 2/3 of the following criteria: fever, leukocytosis, and escalation of vasopressors. The patients were divided into 2 groups: patients with documented infections (Group I) and patients with true SIRS (Group TS) without any evidence of infection. Survival and pre-, intra- and post-ECMO risk factors were analyzed. Among 62 ECMO survivors, 37 (60%) patients developed the post-ECMO SIRS phenomenon, including Group I (n = 22) and Group TS (n = 15). The 30-day survival rate of Group I and TS was 77% and 100%, respectively (p = 0.047), although risk factors were identical. SIRS phenomenon after ECMO decannulation commonly occurs. Differentiating between the similar clinical presentations of SIRS and infection is important and will impact clinical outcomes. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Prognostic significance of brain natriuretic peptide obtained in the ED in patients with SIRS or sepsis.

    Science.gov (United States)

    Chen, Yunxia; Li, Chunsheng

    2009-07-01

    The study was conducted to know the significance of brain natriuretic peptide (BNP) for prognosis of septic patients. The subjects were 1000 patients selected in emergency department of Beijing Chaoyang Hospital of the Capital Medical University (Beijing, China) and were classified into 3 groups as follows: systemic inflammatory response syndrome (SIRS), non-SIRS, and sepsis groups. Plasma serum brain natriuretic peptide (BNP) levels and the positive detection rates of BNP were examined. The BNP level of 100 pg/mL or more was regarded as positive, and then the positive detection rates of BNP of these groups were compared. The prognostic values of BNP and APACHE (Acute physiology and chronic health evaluation) II score for the 28-day mortality were investigated, and their cutoff values for death were determined. There were significant differences in the positive detection rates of BNP between any 2 groups and in 28-day mortality between the patients with SIRS and non-SIRS groups. The BNP level had positive correlation to APACHE II score in 3 groups. Brain natriuretic peptide level of more than 113 pg/mL was independent predictor of death in septic patients. The positive rates of BNP in SIRS and septic patients were significantly higher than that of non-SIRS patients, and this is an index for unfavorable prognosis in septic patients.

  6. Elementary proof of convergence to the mean-field model for the SIR process.

    Science.gov (United States)

    Armbruster, Benjamin; Beck, Ekkehard

    2017-08-01

    The susceptible-infected-recovered (SIR) model has been used extensively to model disease spread and other processes. Despite the widespread usage of this ordinary differential equation (ODE) based model which represents the mean-field approximation of the underlying stochastic SIR process on contact networks, only few rigorous approaches exist and these use complex semigroup and martingale techniques to prove that the expected fraction of the susceptible and infected nodes of the stochastic SIR process on a complete graph converges as the number of nodes increases to the solution of the mean-field ODE model. Extending the elementary proof of convergence for the SIS process introduced by Armbruster and Beck (IMA J Appl Math, doi: 10.1093/imamat/hxw010 , 2016) to the SIR process, we show convergence using only a system of three ODEs, simple probabilistic inequalities, and basic ODE theory. Our approach can also be generalized to many other types of compartmental models (e.g., susceptible-infected-recovered-susceptible (SIRS)) which are linear ODEs with the addition of quadratic terms for the number of new infections similar to the SI term in the SIR model.

  7. Predictive ability of the ISS, NISS, and APACHE II score for SIRS and sepsis in polytrauma patients.

    Science.gov (United States)

    Mica, L; Furrer, E; Keel, M; Trentz, O

    2012-12-01

    Systemic inflammatory response syndrome (SIRS) and sepsis as causes of multiple organ dysfunction syndrome (MODS) remain challenging to treat in polytrauma patients. In this study, the focus was set on widely used scoring systems to assess their diagnostic quality. A total of 512 patients (mean age: 39.2 ± 16.2, range: 16-88 years) who had an Injury Severity Score (ISS) ≥17 were included in this retrospective study. The patients were subdivided into four groups: no SIRS, slight SIRS, severe SIRS, and sepsis. The ISS, New Injury Severity Score (NISS), Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and prothrombin time were collected at admission. The Kruskal-Wallis test and χ(2)-test, multinomial regression analysis, and kernel density estimates were performed. Receiver operating characteristic (ROC) analysis is reported as the area under the curve (AUC). Data were considered as significant if p SIRS severity for NISS (slight vs. no SIRS, 1.06, p = 0.07; severe vs. no SIRS, 1.07, p = 0.04; and sepsis vs. no SIRS, 1.11, p = 0.0028) and APACHE II score (slight vs. no SIRS, 0.97, p = 0.44; severe vs. no SIRS, 1.08, p = 0.02; and sepsis vs. no SIRS, 1.12, p = 0.0028). ROC analysis revealed that the NISS (slight vs. no SIRS, AUC 0.61; severe vs. no SIRS, AUC 0.67; and sepsis vs. no SIRS, AUC 0.77) and APACHE II score (slight vs. no SIRS, AUC 0.60; severe vs. no SIRS, AUC 0.74; and sepsis vs. no SIRS, AUC 0.82) had the best predictive ability for SIRS and sepsis. Quick assessment with the NISS or APACHE II score could preselect possible candidates for sepsis following polytrauma and provide guidance in trauma surgeons' decision-making.

  8. HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.

    Science.gov (United States)

    Kang, Woo Kyu; Devare, Mayur; Kim, Jeong-Yoon

    2017-02-01

    Silent information regulator 2 (Sir2), which is the founding member of the sirtuin family of proteins, is a pro-longevity factor for replicative lifespan (RLS) in Saccharomyces cerevisiae. Sir2 is required for transcriptional silencing at mating type loci, telomeres, and rDNA loci. Sir2 also represses transcription of highly expressed growth-related genes, such as PMA1 and some ribosomal protein genes. Although the Sir2 paralogues Hst1, Hst2, Hst3, and Hst4 occur in S. cerevisiae, none of them could replace the transcriptional regulation of PMA1 by Sir2 in the wild type. In this study, we demonstrate that Hst1, the closest Sir2 paralogue, deacetylates the acetylated lysine 16 of histone H4 (H4K16Ac) and represses PMA1 transcription in the sir2Δ pde2Δ mutant. We further show that Hst1 plays a role in extending the RLS of the sir2Δ pde2Δ mutant. Collectively, our results suggest that Hst1 can substitute for Sir2 by deacetylating H4K16Ac only in the sir2Δ pde2Δ.

  9. Effect of SIRS and sepsis on mortality in alcoholic hepatitis: A systematic review and meta-analysis.

    Science.gov (United States)

    Jaruvongvanich, Veeravich; Sanguankeo, Anawin; Upala, Sikarin

    2016-09-01

    Sepsis is frequently observed in patients with alcoholic hepatitis (AH) and is an important mortality predictor. Several studies have also identified systemic inflammatory response syndrome (SIRS) as a significant prognostic factor. The aim of this study was to systematically review and quantify the effect of SIRS and sepsis on mortality in patients with AH. MEDLINE and EMBASE were searched from its inception till January 2016. Participants in the included studies were adults with AH and those with developed SIRS or sepsis during hospitalization. We estimated the risk ratio (RR) with a 95% confidence interval (CI) of mortality by comparing participants with SIRS vs. non-SIRS and sepsis vs. non-sepsis. Data were extracted from six studies involving 1,264 patients (of whom 507 had SIRS) and four studies involving 57,529 patients (of whom 1,449 had sepsis). SIRS and sepsis were both significantly associated with mortality with RRs of 2.7 (95% CI 1.74-4.14, I2=50%) and 2.8 (95% CI 1.58-4.93, I2=94%), respectively. Not only is sepsis associated with mortality but also SIRS. SIRS may be the initial trigger of cascade events leading to mortality in patients with AH. Identification of the key element of SIRS may thus provide a potential therapeutic target.

  10. Quantitative comparison of PET performance-Siemens Biograph mCT and mMR.

    Science.gov (United States)

    Karlberg, Anna M; Sæther, Oddbjørn; Eikenes, Live; Goa, Pål Erik

    2016-12-01

    Integrated clinical whole-body PET/MR systems were introduced in 2010. In order to bring this technology into clinical usage, it is of great importance to compare the performance with the well-established PET/CT. The aim of this study was to evaluate PET performance, with focus on image quality, on Siemens Biograph mMR (PET/MR) and Siemens Biograph mCT (PET/CT). A direct quantitative comparison of the performance characteristics between the mMR and mCT system was performed according to National Electrical Manufacturers Association (NEMA) NU 2-2007 protocol. Spatial resolution, sensitivity, count rate and image quality were evaluated. The evaluation was supplemented with additional standardized uptake value (SUV) measurements. The spatial resolution was similar for the two systems. Average sensitivity was higher for the mMR (13.3 kcps/MBq) compared to the mCT system (10.0 kcps/MBq). Peak noise equivalent count rate (NECR) was slightly higher for the mMR (196 kcps @ 24.4 kBq/mL) compared to the mCT (186 kcps @ 30.1 kBq/mL). Scatter fractions in the clinical activity concentration range yielded lower values for the mCT (34.9 %) compared to those for the mMR (37.0 %). Best image quality of the systems resulted in approximately the same mean hot sphere contrast and a difference of 19 percentage points (pp) in mean cold contrast, in favour of the mCT. In general, point spread function (PSF) increased hot contrast and time of flight (TOF) increased both hot and cold contrast. Highest hot contrast for the smallest sphere (10 mm) was achieved with the combination of TOF and PSF on the mCT. Lung residual error was higher for the mMR (22 %) than that for the mCT (17 %), with no effect of PSF. With TOF, lung residual error was reduced to 8 % (mCT). SUV was accurate for both systems, but PSF caused overestimations for the 13-, 17- and 22-mm spheres. Both systems proved good performance characteristics, and the PET image quality of the mMR was close to that of the m

  11. Occupational exposure following Yttrium-90 microspheres SIR therapy

    International Nuclear Information System (INIS)

    Fontaine, P.; Boirie, G.; Dieudonne, A.; Leguludec, D.; Lebtahi, R.; Ben Reguiga, M.

    2015-01-01

    Full text of publication follows. Introduction: Selective Internal Radiation Therapy (SIRT) is a promising technique for solid hepatic neoplasms treatment. SIRT consists in implanting radioactive microspheres (RMS) in targeted hepatic lesions via femoral artery. Two RMS-Therapsheres [glass-microspheres/TSR] and Sir-Spheres [resin-spheres/SSR]- are marketed in the European market, both radiolabeled with Yttrium-90. The objective of this study is to assess occupational exposure for nuclear medicine, radiology and clinical staff involved in Y 90 -RMS preparation and implantation. Materials and methods: The study was conducted on 20 patients treated for Hepato-Cellular Carcinoma: 10 treated with TSR and 10 with SSR. Dose rate (DR, mSv/h) or absorbed doses (mSv) measurements were made during all steps of TSR and SSR handling: sources receipt and unpacking, preparation, transport to radiology, implantation, and patient care. Measurements were made with portable ionization chamber(Babyline/Nardeux), spectrometer(FieldSpect/Aries), digital dosimeter (NED/Unfors) and operational dosimeter (Mk2/Siemens). Values were expressed as mean±SD. Results: patients received of 1.8 GBq to 3.1 GBq of TSR and 0.55 GBq to 2.4 GBq of SSR. TSR were delivered ready-to-use with the prescribed activity. For SSR only one activity was commercially available and shipped (3 GBq at calibration-time)requiring a preparation step to adjust needed activity. DR measured during RMS was 1723 ± 157 μSv/h SSR and 1189 ± 92 μSv/h for TSR. When preparing spheres in radiopharmacy, fingers and whole body doses were respectively 8326 ± 2360 μSv and 12.3 ± 5,2 μSv for Sir-Spheres vs. 33.5 ± 7.8 μSv and 1.1 ± 0.3 μSv for TSR. DR in contact with carrying case during RMS transfer to radiology were 299 ± 102 μSv/h for SSR and 5.3 ± 1.2 μSv/h for TSR. During RMS infusion, radiologist's finger doses were limited to 3.6 ± 1 μSv for SSR and 0.7± 0.3 μSv for TSR. Finally, following RMS

  12. SIS and SIR Epidemic Models Under Virtual Dispersal.

    Science.gov (United States)

    Bichara, Derdei; Kang, Yun; Castillo-Chavez, Carlos; Horan, Richard; Perrings, Charles

    2015-11-01

    We develop a multi-group epidemic framework via virtual dispersal where the risk of infection is a function of the residence time and local environmental risk. This novel approach eliminates the need to define and measure contact rates that are used in the traditional multi-group epidemic models with heterogeneous mixing. We apply this approach to a general n-patch SIS model whose basic reproduction number [Formula: see text] is computed as a function of a patch residence-time matrix [Formula: see text]. Our analysis implies that the resulting n-patch SIS model has robust dynamics when patches are strongly connected: There is a unique globally stable endemic equilibrium when [Formula: see text], while the disease-free equilibrium is globally stable when [Formula: see text]. Our further analysis indicates that the dispersal behavior described by the residence-time matrix [Formula: see text] has profound effects on the disease dynamics at the single patch level with consequences that proper dispersal behavior along with the local environmental risk can either promote or eliminate the endemic in particular patches. Our work highlights the impact of residence-time matrix if the patches are not strongly connected. Our framework can be generalized in other endemic and disease outbreak models. As an illustration, we apply our framework to a two-patch SIR single-outbreak epidemic model where the process of disease invasion is connected to the final epidemic size relationship. We also explore the impact of disease-prevalence-driven decision using a phenomenological modeling approach in order to contrast the role of constant versus state-dependent [Formula: see text] on disease dynamics.

  13. PERSONAL CROSS-CULTURAL COMMUNICATIVE COMPETENCE IN BIOGRAPHICAL AND HAGIOGRAPHICAL LIFE AND ACTIVITIES OF SAINT ANTHIM THE IBERIAN (GEORGIAN)

    OpenAIRE

    Adam VAKHTANG AKHALADZE

    2016-01-01

    In this study we analyze the biographical and hagiographical life and multifaceted activities of St. Anthim the Iberian in cross-cultural communicative dimension. Modern Post-Global world and its Weltanschauung need not onlytrans(cross)-cultural, but also trans-historical contexts. We have designated the existence of trans-cultural polylogue (dialogue of many) between all historical eras and ethnicities with their cultural codes and symbols. Our research enabled us to identify the following p...

  14. Organisational climate, biographical factors, and job satisfaction : a national survey of nurses in the Republic of Ireland

    OpenAIRE

    Curtis, Elizabeth Ann

    2005-01-01

    Background and Justification for the Study: This study grew out of a longstanding interest in job satisfaction and its relationship with organisational climate. Several research studies have demonstrated the importance of employee job satisfaction. There is, however, a general consensus in the literature on nursing that job satisfaction among nurses is relatively low. The effects of biographical factors, such as age and gender, on job satisfaction have been examined in previous studies but th...

  15. Author Details

    African Journals Online (AJOL)

    Ashour, MM. Vol 12, No 4 (2000) - Articles ROLE OF DIAGNOSTIC LAPAROSCOPY IN OBSCURE ASCITES Details. ISSN: 1110-5607. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

  16. Author Details

    African Journals Online (AJOL)

    Masoud, M. Vol 12, No 4 (2000) - Articles ROLE OF DIAGNOSTIC LAPAROSCOPY IN OBSCURE ASCITES Details. ISSN: 1110-5607. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

  17. Author Details

    African Journals Online (AJOL)

    RIZZO, R. Vol 7, No 2 (2001) - Articles Variental differences AND polymorphism in palm oil: a case study of palm oils blended with coconut oil. Details. ISSN: 1118-0579. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Effet des huiles essentielles des feuilles et des extrémités fleuries de Cupressus lusitanica sur la Tique Rhipicephalus lunulatus à L'ouest-Cameroun Details PDF · Vol 4, No 3 (2004) - Articles Potentiel de germination de Moringa oleifera Lam. Sous différents traitements à Dshang dans les Hautes terres de l\\'Ouest- ...

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    Relationship between permethrin susceptiblity and elevated esterase in clones of cotton aphid (Homoptera:Aphididae) Details · Vol 39 (1999) - Articles Studies on some esterases of Coccinella septempunctata Brukii (Coleoptera: Coccinellidae) with varying degrees of insecticide tolerance, and implications for integrated ...

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    BEFIDI, Rosa M. Vol 2 (2002): Supplement - Articles Prevalence of Multiple Concomitant Intestinal Parasitic Infections in Simbok a Malaria Endemic Village in Cameroon. Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    QUAKYI, A.I.. Vol 2 (2002): Supplement - Articles A Longitudinal Study of the Role of T Cell subset, Th1/Th2 cytokines and antiplasmodial antibodies in uncomplicated Malaria in a Village Population Chronically Exposed to Plasmodium falciparum Malaria. Details PDF · AJOL African Journals Online. HOW TO USE AJOL.

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    KOUONTCHOU, Samuel. Vol 2 (2002): Supplement - Articles Prevalence of Multiple Concomitant Intestinal Parasitic Infections in Simbok a Malaria Endemic Village in Cameroon. Details PDF · Vol 2 (2002): Supplement - Articles A Longitudinal Study of the Role of T Cell subset, Th1/Th2 cytokines and antiplasmodial ...

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    ALAKE, J. Vol 2 (2002): Supplement - Articles A Longitudinal Study of the Role of T Cell subset, Th1/Th2 cytokines and antiplasmodial antibodies in uncomplicated Malaria in a Village Population Chronically Exposed to Plasmodium falciparum Malaria. Details PDF · AJOL African Journals Online. HOW TO USE AJOL.

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    Booth, Wayne C. Vol 14, No 1 (2001): Religion: Rhetoric and Politics - Articles Can Rhetorology Yield a Truce Between Science and Religion? Details. ISSN: 1011-7601. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Kamwendo, Gregory H. Vol 15 (2001) - Articles Book Review: Neville Alexander, (ed), Social Dynamics - special issue on 'Language Policies in Africa', Ayo Bamgbose, Language and Exclusion: The consequences of language policies in Africa Details PDF. ISSN: 1016-0728. AJOL African Journals Online. HOW TO USE ...

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    Brown, Duncan. Vol 16, No 2 (2002): Continental Africans & the Question of Identity - Articles Environment and Identity: Douglas Livingstone's A Littoral Zone Details. ISSN: 0256-004. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Aderinokun, GA. Vol 9, No 1 (1999) - Articles Relative Influence Of Sociodemographic Variables On Oral Health And Habits Of Some Nigerian School Children Abstract · Vol 9, No 4 (1999) - Articles Oral health services in Nigeria Details. ISSN: 0189-2657. AJOL African Journals Online. HOW TO USE AJOL.

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    Body composition assessment in 221 Nigerian adults using bioelectrical impedance measurements. Abstract · Vol 10, No 3 (2000) - Articles Near-patient testing in the developing countries. Evaluation of a hemocue blood glucose analyser. Details · Vol 11, No 1 (2001) - Articles LDL-peroxidation, and total atioxidant status in ...

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    Love, Alison. Vol 29, No 2 (2002) - Articles Policy-makers, the Press and Politics: Reporting a Public Policy Document Details. ISSN: 0379-0622. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Ram, S. Vol 12, No 1 (2000) - Articles Ionospheric Plasma Heating During Powerful Wave Propagation. Details. ISSN: 1015-079X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

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    Batisani, NJ. Vol 12 (2003) - Articles A review of Botswana soil fertility research: current status and prospects. Details. ISSN: 1021-0873. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Badrawi, H.M.. Vol 12, No 3 (2000) - Articles EFFECTS OF SOLCOSERYL AND LOW DOSE ASPIRIN ON UTERINE BLOOD FLOW Details. ISSN: 1110-5607. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Lipenga, Allan. Vol 16 (2002) - Articles Le Chichewa essai de description dans une perspective didactique. Details PDF. ISSN: 1016-0728. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    EKODECK, EK. Vol 3, No 2 (2003) - Articles Intêret de l'alterologie normative dans la sélection des argiles kaoliniques pour la production industrielle des caoutchoucs, du papier, des peintures et des plastiques. Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    alterologie normative dans la sélection des argiles kaoliniques pour la production industrielle des caoutchoucs, du papier, des peintures et des plastiques. Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for ...

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    Sakwe, AM. Vol 2, No 3 (2002) - Articles Onchocerciasis Spectrum and Immunoglobulin G Responses of Endemic Normal subjects to Selected Recombinant Peptides Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Idowu, OO. Vol 8, No 1 (2003) - Articles Evaluation of Different Substrates and Combinations on the Growth of Pleurotus pulmonarius (Fries) Quelet (Sajor-caju) Details. ISSN: 1118-2733. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Tetiker, H. Vol 17, No 3 (2014) - Articles Central region morphometry in a child brain; Age and gender differences. Abstract PDF · Vol 20, No 2 (2017) - Articles MRI-based detailed evaluation of the anatomy of the human coccyx among Turkish adults. Abstract PDF. ISSN: 1119-3077. AJOL African Journals Online. HOW TO ...

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    Kioni, P N. Vol 9, No 1 (2007) - Articles Detailed structure of pipe flow with water hammer oscillations. Abstract. ISSN: 1561-7645. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

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    Hady, A. Vol 12, No 2 (2000) - Articles CLINICAL AND HISTOPATHOLOGICAL STUDY OF VOCAL CORD POLYPS Details. ISSN: 1110-5607. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Development of a trap to contaminate variegated grasshoppers (Zonocerus variegatus L.) (Orthoptera: Pyrgomorphidae) with Metarrhyzium flavo-viride Gams & Rozsypal in the field. Details · Vol 40, No 1 (2007) - Articles Yam pests in the Ashanti and Brong Ahafo regions of Ghana: A study of farmers\\' indigenous technical ...

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    Focho, DA. Vol 2, No 1 (2002) - Articles Observations on the Meiotic Process in the African Pest Grasshopper Taphronota thaelephora Stal. (Orthoptera : Pyrgomorphidae) Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Details · Vol 4, No 2 (2000) - Articles Book Review: J. Kelly. Rethinking Industrial Relations: Mobilization, Collectivism and Long Waves. K. Moody. Workers in a Lean World: Unions in the International Economy. B. Nissen. Which Direction for Organized Labour? Essays on Organizing, Outreach and Internal Transformation

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    Dalamba, Yolisa. Vol 14, No 1 (2000): Ethnicity and Identity - Articles Towards An African Renaissance: Some Thoughts on the Renaissance Conference September 28th & 29th 1998 and its Future Implications Details. ISSN: 0256-004. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

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    Comarof, John. Vol 1999, No 3-4 (1999) - Articles Alien-Nation: Zombies, Immigrants and Millennial Capitalism Details. ISSN: 0850-8712. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Agbodaze, DA. Vol 31, No 1 (1991) - Articles Biochemical characteristics of Plesiomonas shigelloides isolated from prawns (Macrobrachium sp.) and water sampled from the shore-line of the Volta River, Ghana Details. ISSN: 0855-1448. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

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    Angwe, CA. Vol 1, No 1 (2001) - Articles Culture potentials of Macrobrachium sp in Cameroon Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

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    Alexander, Neville. Vol 4, No 2 (2000) - Articles Book Review: CRD Halisi. Black Political Though in the Making of South African Democracy Details PDF. ISSN: 1027-4332. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Erasmus, GJ. Vol 1, No 1 (2001) - Articles Genetic parameter estimates for growth traits in purebred Gudali and two-breed synthetic Wakwa beef cattle in a tropical environment. Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Oyewunmi, O K. Vol 2, No 1 (1999) - Articles Bacterial pathogens Isolated After Surgical Hand Scrub at the Lagos University Teaching Hospital. Details. ISSN: 1119-1716. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Abstract PDF · Vol 13, No 2 (2001) - Articles Quarterly clinic 'Cerebral malaria' Details · Vol 22, No 4 (2010) - Articles Paediatric Wandering Spleens in Malawi Abstract PDF · Vol 23, No 1 (2011) - Articles Ward Round-A rare tumor of the kidney resulting in hypertension, renal failure and a cerebrovascular accident in a young ...

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    Mika, A. Vol 8, No 1 (2002) - Articles Phytochemical, Cytotoxicity and microbial screening of euphorbia hirta linn. Details. ISSN: 1118-0579. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Chidester, David. Vol 15, No 2 (2002): - Articles Credo Mutwa, Zulu Shaman: The invetion and Appropriation of indigenous Authenticity in African Folk religion. Details. ISSN: 1011-7601. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Ghirmay, Senait. Vol 12, No 1 (1998) - Articles Characterisitics and chemical composition of the oil of Cucurbita pepo seeds. Details PDF. ISSN: 1726-801X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Wasunna, M. Vol 80, No 8 (2003): - Articles Visceral leishmaniasis with concomitant post kala-asar Dermal leishmaniasis responds to oral sitamaquine: case report. Details PDF. ISSN: 0012-835X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Mbui, J. Vol 80, No 8 (2003): - Articles Visceral leishmaniasis with concomitant post kala-asar Dermal leishmaniasis responds to oral sitamaquine: case report. Details PDF. ISSN: 0012-835X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Comarof, Jean. Vol 1999, No 3-4 (1999) - Articles Alien-Nation: Zombies, Immigrants and Millennial Capitalism Details. ISSN: 0850-8712. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Choi, Soung-ai. Vol 3, No 1 (1999) - Articles Whose Honour, Whose Humiliation: Women, Men and the Economic Crisis in South Korea Details. ISSN: 1024-9451. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Bowles, Roger. Vol 31, No 1 (2001) - Articles Enterprise Compliance with Local Authority Regulation in Kenya Details. ISSN: 1995-641X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Okeke, EO. Vol 10 (2006) - Articles Analysis of Stokes waves theory as a diffusion problem. Abstract · Vol 11 (2007) - Articles On the impact of wave-current on Stokes waves. Abstract. ISSN: 1116-4336. AJOL African ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Obtaining the green's function for electromagnetic waves propagating in layered in-homogeneous thin film media of spherical particles on a substrate. Abstract · Vol 20, No 2 (2008) - Articles solution growth and ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 8 (2004) - Articles Further on stokes expansions for the finite amplitude water waves. Abstract · Vol 11 (2007) - Articles On the effects of wave steepness on higher order Stokes waves. Abstract. ISSN: 1116-4336.

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    Kale, Ndiva Kofele. Vol 8, No 1 (2001) - Articles Good Governance as Political Conditionality Details PDF. ISSN: 1024-0969. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News.

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    GODINHO, P. Vol 6 (1997) - Articles Some aspects of the reproduction of female corvine fish Plagioscion squamosissimus Heckel, 1840 (Scienidae) in a reservoir of southern Brazil Details. ISSN: 0795-0101. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Gontrand, C. Vol 14 (2002) - Articles Modélisation électrique de transistors bipolaires radiofréquences a hétérojonction Compatibles CMOS Details. ISSN: 1111-0902. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Odigie, IP. Vol 10, No 4 (2000) - Articles High dose vitamin E administration attenuates hypertensin in 2-Kidney 1 Clip Goldblatt hypertensive rats. Details. ISSN: 0189-2657. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Wasunna, AO. Vol 80, No 9 (2003): - Articles Neonatal bacterial meningitis at the newborn unit of Kenyatta National Hospital Details PDF · Vol 88, No 1 (2011) - Articles Clinical Risk Index for Babies (Crib) Ii Score as a Predictor of Neonatal Mortality among Low Birth Weight Babies at Kenyatta National Hospital Abstract PDF ...

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    Musoke, RN. Vol 80, No 9 (2003): - Articles Neonatal bacterial meningitis at the newborn unit of Kenyatta National Hospital Details PDF · Vol 89, No 2 (2012) - Articles The impact of partial kangaroo mother care on growth rates and duration of hospital stay of low birth weight infants at the Kenyatta National Hospital, Nairobi

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    Workalemahu, Bantikassegn. Vol 13, No 2 (1999) - Articles Electronic propertiesof junctions between aluminium and polyaniline doped with dodecylbenzene sulphonate. Details PDF. ISSN: 1726-801X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Onuoha, AIN. Vol 1, No 1 (2002) - Articles The Vibration Effect Of Unbalance Mass On Vertical Centrifugal Pump Rotor Details. ISSN: 1596-3497. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Equus asinus) in cultivation tasks in Zimbabwe Details. ISSN: 1019-7788. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to get access ... No 3 (2009) - Articles Rising rates of Caesarean sections: an audit of Caesarean sections in a specialist private practice ... An audit of surgical termination of pregnancy at a level 1 health facility in South Africa Abstract PDF · Vol 54, No 6 ...

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    Revathi, G. Vol 80, No 9 (2003): - Articles Neonatal bacterial meningitis at the newborn unit of Kenyatta National Hospital Details PDF · Vol 83, No 6 (2006): - Articles Bronchoscopic study on aetiology of chronic cough in HIV-infected adults with negative sputum smears for mycobacterium tuberculosis at Kenyatta National ...

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    Edufunke, IO. Vol 10, No 3 (2000) - Articles Toxicity test of water homogenate of cissus populnea stem in mice and its effects on weights of some organs, serum gonadotropins, lipids and uric acid in male albino rats. Details. ISSN: 0189-2657. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for ...

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    Lema, VM. Vol 80, No 9 (2003): - Articles Fournier's gangrene complicating vasectomy. Details PDF · Vol 86, No 6 (2009) - Articles Therapeutic misconception and clinical trials in sub-saharan Africa: A review. Abstract PDF · Vol 86, No 11 (2009) - Articles HIV/AIDS and pregnancy-related deaths in Blantyre, Malawi

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    Green, J.M.. Vol 10, No 1 (2001) - Articles Information from Radio Telemetry on movements and exploitation of naturalized Rainbow trout, Oncorhynchus mykiss (Walbaum), in Kenya cold water streams. Details. ISSN: 0002-0036. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

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    Nardi, G. Vol 12, No 1 (2004) - Articles Nomenclatural and taxonomic notes on some Endomia Castelnau de Laporte (Coleoptera : Anthicidae) : short communication. Details · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Ziady, C. Vol 1, No 1 (2003) - Articles Infliximab (Revellex) inflammatory bowel disease: guidelines. Details. ISSN: 1812-1659. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News.

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    Nzogang, JF. Vol 3, No 3 (2003) - Articles Effet des huiles essentielles des feuilles et des extrémités fleuries de Cupressus lusitanica sur la Tique Rhipicephalus lunulatus à L'ouest-Cameroun Details PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    An open study of the safety and efficacy of ranitidine Bismuth citrate in the treatment of patients with Helicobacter Pylori-associated duodenal ulcer. Details · Vol 18, No 4 (2008) - Articles Haemosuccus pancreaticus as a rare initial manifestation of pancreatic carcinoma. Abstract · Vol 22, No 2 (2012) - Articles Intravesical ...

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    OKANSEY, F. Vol 8, No 1 (2000) - Articles Adolescent Students' Perception of their career guidance and counselling needs. Details. ISSN: 1117-1421. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  11. Disasters and vulnerabilities in the Foreman and Kennedy road informal settlements: Biographical influences

    Directory of Open Access Journals (Sweden)

    Bethuel Sibongiseni Ngcamu

    2012-11-01

    Full Text Available As the towards the end of the homelands in the post-apartheid South Africa, there was a scramble of poverty stricken African black youth to the most severe vulnerable and disaster prone urban areas in search for formal job opportunities. The main purpose of this empirical study is to investigate the extent in which how the biographical profiles (age, gender, marital status, education levels, occupation (males and females, children and tenure can influence vulnerability and disasters in these informal settlements. A quantitative research design was adopted and a survey method was used, whereby questionnaires were administered by the researcher to a population of 240, whereby, 140 questionnaires were completed generating a response rate of 63.6%. The findings of this study reveals that the majority of the respondents in the Foreman and Kennedy Road informal settlements are black, poverty stricken, unemployed and who are suffered economic difficulties that make them highly vulnerable to disasters. This study will act an advisory role to the decision-makers as the research findings shows that in the foreseeable future in South Africa, informal settlements will be an intergral feature of formal housing, which requires urban planners to include such settlements to housing planning.

  12. [Risk-taking and HIV/Aids prevention: a biographical approach to sexual behavior in Portugal].

    Science.gov (United States)

    Aboim, Sofia

    2012-01-01

    On the basis of a representative survey carried out in 2007 of the Portuguese population aged between 18 and 65, this study investigates the impact of factors during the course of sexual life on risk-taking behavior and perceptions among 3055 heterosexual men and women. A number of sexual biography profiles were identified through cluster analysis of indicators related to the identity, number and sequence of partners throughout life. We discovered different profiles, from systematic occasional partnerships and use of paid sex, more frequent among men, to the single partner profile, which is more prevalent among women. By carrying out several linear regression analyses, we were able to evaluate the predictive impact of biographical factors on condom use and prevention behavior. Our results indicate that sexual biographies are more important in explaining the prevalence of condom use with different sexual partners. On the other hand, fear of infection and information on HIV transmission seem to influence the cognitive mobilization of prevention strategies and change of sexual behavior. However, condom use is still more dependent on sexual life pattern and interaction with sexual partners.

  13. New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

    Science.gov (United States)

    Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

    2017-12-01

    The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

  14. SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma.

    Science.gov (United States)

    Miyake, Yasuhiro; Yasunaka, Tetsuya; Ikeda, Fusao; Takaki, Akinobu; Nouso, Kazuhiro; Yamamoto, Kazuhide

    2012-01-01

    In acetaminophen-induced acute liver failure (ALF), the hepatic coma grade worsens and mortality rates increase, as the number of systemic inflammatory response syndrome components fulfilled (SIRS score) increases. This study aimed to investigate the impact of SIRS score on clinical features of non-acetaminophen-related ALF. Ninety-nine patients with non-acetaminophen-related ALF with hepatic coma who did not undergo liver transplantation were investigated. Each patient was given a SIRS score of 0, 1, 2, 3 or 4 at the time of diagnosis. At the diagnosis of ALF with hepatic coma, with the increase of SIRS score, hepatic coma grade and prothrombin activity were deteriorated. After the diagnosis of ALF with hepatic coma, 25 patients (25%) developed acute respiratory distress syndrome (ARDS), 31 patients (31%) developed disseminated intravascular coagulation (DIC), and 21 patients (22%) developed acute renal failure (ARF). Thirty-eight patients (38%) developed MOF. With the increase of SIRS score, frequencies of the development of ARDS, DIC and MOF increased. ARF was more frequently developed in patients with a SIRS score of 2 or higher. Overall, 36 patients (36%) survived. Overall survival rate was 66% in 29 patients with a score of 0, 43% in 21 patients with a score of 1, 17% in 29 patients with a score of 2 and 15% in 20 patients with a score of 3 or 4. SIRS score will be useful for predicting not only the overall survival but also the development of complications such as ARDS, DIC and MOF in non-acetaminophen-related ALF with hepatic coma.

  15. Immunoparalysis: Clinical and immunological associations in SIRS and severe sepsis patients.

    Science.gov (United States)

    Papadopoulos, Panagiotis; Pistiki, Aikaterini; Theodorakopoulou, Maria; Christodoulopoulou, Theodora; Damoraki, Georgia; Goukos, Dimitris; Briassouli, Efrossini; Dimopoulou, Ioanna; Armaganidis, Apostolos; Nanas, Serafim; Briassoulis, George; Tsiodras, Sotirios

    2017-04-01

    This study was designed to identify changes in the monocytic membrane marker HLA-DR and heat shock proteins (HSPs) in relation to T-regulatory cells (T-regs) and other immunological marker changes in patients with systemic inflammatory response syndrome (SIRS) or sepsis/septic shock. Healthy volunteers, intensive care unit (ICU) patients with SIRS due to head injury and ICU patients with severe sepsis/septic shock were enrolled in the current study. Determination of CD14+/HLA-DR+ cells, intracellular heat-shock proteins and other immunological parameters were performed by flow cytometry and RT-PCR techniques as appropriate. Univariate and multivariate analysis examined associations of CD14/HLA-DR, HSPs, T-regs and suppressor of cytokine signalling (SOCS) proteins with SIRS, sepsis and outcome. Fifty patients (37 with severe sepsis and 13 with SIRS) were enrolled, together with 20 healthy volunteers used as a control group. Compared to healthy individuals, patients with SIRS and severe sepsis showed progressive decline of their CD14/HLA-DR expression (0% to 7.7% to 50% within each study subpopulation, pSIRS patients compared to controls and fell significantly in severe sepsis/septic shock patients (pSIRS and sepsis were found for CD14/HLA-DR expression and monocyte and polymorphonuclear cell levels of HSP70 and 90. The role of these biomarkers in assessing the prognosis of sepsis needs to be further explored and validated in prospective studies. Copyright © 2017 Elsevier Ltd. All rights reserved.

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    Etude des paramètres de compressibilité et de cisaillement de l'argile-sableuse de la région de Douala au Cameroun Details PDF · Vol 3, No 2 (2003) - Articles Effet du remaniement par décompression de L'échantillon sur la résistance au cisaillement de l'argile-sableuse jaunatre de Ndogbong dans la région de Douala ...

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    Bahi, Aghi. Vol 7, No 1 (2003) - Articles La « Sorbonne » d'Abidjan: rêve de démocratie ou naissance d'un espace public? Details PDF. ISSN: 1027-4332. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

  18. The participants' perspective: how biographic-narrative intervention influences identity negotiation and quality of life in aphasia.

    Science.gov (United States)

    Corsten, Sabine; Schimpf, Erika J; Konradi, Jürgen; Keilmann, Annerose; Hardering, Friedericke

    2015-01-01

    People with aphasia experience a pronounced decrease in quality of life (QoL). Beyond that identity negotiation is hindered, which is crucial for QoL. Biographic-narrative approaches use life story telling to support identity (re)development after disruptive events like stroke. Because of the language deficits inherent in aphasia such 'talk-based' approaches have to be modified for an optimal use. To evaluate an adapted interdisciplinary biographic-narrative intervention using quantitative measures of health-related quality of life (HRQL) and mood. Additionally, semi-structured interviews were conducted to gain a deeper understanding of identity development processes in people with aphasia. Twenty-seven participants with various types of chronic aphasia were enrolled. The biographic narrative intervention consisted of five face-to-face in-depth interviews and seven group sessions conducted over 10 weeks in a mixed-method design with pre- and post-tests and a follow-up assessment 3 months post-intervention. For quantitative evaluation the Aachen Life Quality Inventory (ALQI), the Satisfaction with Life Scale (SWLS) and the Visual Analog Mood Scales (VAMS) were used. Semi-structured interviews were conducted post-treatment, including questions concerning the participants' experiences with the intervention and identity change. Results were analysed using interpretative principles from Grounded Theory. For all 27 participants, we found significant and stable growth in HRQL. Self-reported states of mood also improved. As expected, overall cognitively based life satisfaction did not change. The interviews revealed two main categories: 'evaluation of the face-to-face interviews' and 'evaluation of the group sessions'. Further analysis found four overlapping main themes which were identified as identity issues: agency, control, disease concept and doing things. Our quantitative and qualitative results demonstrated the benefits associated with the biographic

  19. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  20. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

    Directory of Open Access Journals (Sweden)

    Mahshid Talebi-Taher

    2014-06-01

    Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

  1. Constitutive Relation of Engineering Material Based on SIR Model and HAM

    Directory of Open Access Journals (Sweden)

    Haoxiang He

    2014-01-01

    Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

  2. SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

    Science.gov (United States)

    Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

    2010-01-01

    Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

  3. Increased FGF21 plasma levels in humans with sepsis and SIRS.

    Science.gov (United States)

    Gariani, Karim; Drifte, Geneviève; Dunn-Siegrist, Irène; Pugin, Jérôme; Jornayvaz, François R

    2013-01-01

    Fibroblast growth factor 21 (FGF21) is a key regulator in glucose and lipid metabolism and its plasma levels have been shown to be increased not only in humans in different situations such as type 2 diabetes, obesity, and nonalcoholic fatty liver disease but also in animal models of sepsis and pancreatitis. FGF21 is considered as a pharmacological candidate in conditions associated with insulin resistance. The aim of this study was to compare FGF21 plasma levels in patients with sepsis, in patients with systemic inflammatory response syndrome (SIRS), and in healthy controls. We measured FGF21 plasma concentrations in 22 patients with established sepsis, in 11 with SIRS, and in 12 healthy volunteers. Here, we show that FGF21 levels were significantly higher in plasma obtained from patients with sepsis and SIRS in comparison with healthy controls. Also, FGF21 levels were significantly higher in patients with sepsis than in those with noninfectious SIRS. FGF21 plasma levels measured at study entry correlated positively with the APACHE II score, but not with procalcitonin levels, nor with C-reactive protein, classical markers of sepsis. Plasma concentrations of FGF21 peaked near the onset of shock and rapidly decreased with clinical improvement. Taken together, these results indicate that circulating levels of FGF21 are increased in patients presenting with sepsis and SIRS, and suggest a role for FGF21 in inflammation. Further studies are needed to explore the potential role of FGF21 in sepsis as a potential therapeutic target.

  4. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

    Science.gov (United States)

    Talebi-Taher, Mahshid; Babazadeh, Shahin; Barati, Mitra; Latifnia, Maryam

    2014-01-01

    Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), procalcitonin (PCT), and Interleukin-6 (IL-6) to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS) in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC) count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98%) and negative predictive value (98.6%) and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI). On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

  5. Strategies for continuing professional development among younger, middle-aged, and older nurses: a biographical approach.

    Science.gov (United States)

    Pool, Inge A; Poell, Rob F; Berings, Marjolein G M C; ten Cate, Olle

    2015-05-01

    A nursing career can last for more than 40 years, during which continuing professional development is essential. Nurses participate in a variety of learning activities that correspond with their developmental motives. Lifespan psychology shows that work-related motives change with age, leading to the expectation that motives for continuing professional development also change. Nevertheless, little is known about nurses' continuing professional development strategies in different age groups. To explore continuing professional development strategies among younger, middle-aged, and older nurses. A qualitative study using semi-structured interviews, from a biographical perspective. Data were analysed using a vertical process aimed at creating individual learning biographies, and a horizontal process directed at discovering differences and similarities between age groups. Twenty-one nurses in three age groups from general and academic hospitals in the Netherlands. In all age groups, daily work was an important trigger for professional development on the ward. Performing extra or new tasks appeared to be an additional trigger for undertaking learning activities external to the ward. Learning experiences in nurses' private lives also contributed to their continuing professional development. Besides these similarities, the data revealed differences in career stages and private lives, which appeared to be related to differences in continuing professional development strategy; 'gaining experience and building a career' held particularly true among younger nurses, 'work-life balance' and 'keeping work interesting and varied' to middle-aged nurses, and 'consistency at work' to older nurses. Professional development strategies can aim at performing daily patient care, extra tasks and other roles. Age differences in these strategies appear to relate to tenure, perspectives on the future, and situations at home. These insights could help hospitals to orientate continuing

  6. Academic detailing.

    Science.gov (United States)

    Shankar, P R; Jha, N; Piryani, R M; Bajracharya, O; Shrestha, R; Thapa, H S

    2010-01-01

    There are a number of sources available to prescribers to stay up to date about medicines. Prescribers in rural areas in developing countries however, may not able to access some of them. Interventions to improve prescribing can be educational, managerial, and regulatory or use a mix of strategies. Detailing by the pharmaceutical industry is widespread. Academic detailing (AD) has been classically seen as a form of continuing medical education in which a trained health professional such as a physician or pharmacist visits physicians in their offices to provide evidence-based information. Face-to-face sessions, preferably on an individual basis, clear educational and behavioural objectives, establishing credibility with respect to objectivity, stimulating physician interaction, use of concise graphic educational materials, highlighting key messages, and when possible, providing positive reinforcement of improved practices in follow-up visits can increase success of AD initiatives. AD is common in developed countries and certain examples have been cited in this review. In developing countries the authors have come across reports of AD in Pakistan, Sudan, Argentina and Uruguay, Bihar state in India, Zambia, Cuba, Indonesia and Mexico. AD had a consistent, small but potentially significant impact on prescribing practices. AD has much less resources at its command compared to the efforts by the industry. Steps have to be taken to formally start AD in Nepal and there may be specific hindering factors similar to those in other developing nations.

  7. Fast differentiation of SIRS and sepsis from blood plasma of ICU patients using Raman spectroscopy.

    Science.gov (United States)

    Neugebauer, Ute; Trenkmann, Sabine; Bocklitz, Thomas; Schmerler, Diana; Kiehntopf, Michael; Popp, Jürgen

    2014-04-01

    Currently, there is no biomarker that can reliable distinguish between infectious and non-infectious systemic inflammatory response syndrome (SIRS). However, such a biomarker would be of utmost importance for early identification and stratification of patients at risk to initiate timely and appropriate antibiotic treatment. Within this proof of principle study, the high potential of Raman spectroscopy for the fast differentiation of non-infectious SIRS and sepsis is demonstrated. Blood plasma collected from 70 patients from the intensive care unit (31 patients with sepsis and 39 patients classified with SIRS without infection) was analyzed by means of Raman spectroscopy. A PCA-LDA based classification model was trained with Raman spectra from test samples and yielded for sepsis a sensitivity of 1.0 and specificity of 0.82. These results have been confirmed with an independent dataset (prediction accuracy 80%). Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Cartographic feature extraction with integrated SIR-B and Landsat TM images

    Science.gov (United States)

    Welch, R.; Ehlers, Manfred

    1988-01-01

    A digital cartographic multisensor image database of excellent geometry and improved resolution was created by registering SIR-B images to a rectified Landsat TM reference image and applying intensity-hue-saturation enhancement techniques. When evaluated against geodetic control, RMSE(XY) values of approximately + or - 20 m were noted for the composite SIR-B/TM images. The completeness of cartographic features extracted from the composite images exceeded those obtained from separate SIR-B and TM image data sets by approximately 10 and 25 percent, respectively, indicating that the composite images may prove suitable for planimetric mapping at a scale of 1:100,000 or smaller. At present, the most effective method for extracting cartographic information involves digitizing features directly from the image processing display screen.

  9. Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

    Science.gov (United States)

    Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

    2017-11-01

    The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Predicting changes in reported notifiable disease rates for New Zealand using a SIR modelling approach

    Science.gov (United States)

    McBride, Graham; Slaney, David; Tait, Andrew

    2013-04-01

    The New Zealand health system has defined as 'notifiable' over 50 diseases. Of these campylobacteriosis is the most commonly reported comprising 41% of all notifications in 2011 (presently about 150 illness cases per 100,000 population per annum). Furthermore, the incidence of this mild illness, which is potentially waterborne, is under-reported by at least an order-of-magnitude. Increased downstream pathogen loads and/or disease incidence have been found to be associated with increased rainfall, particularly in agricultural landscapes. Therefore, given the predominance of agricultural land uses in New Zealand, transmission and exposure to its agent (thermotolerant Campylobacter bacteria) may be affected by changing rainfall and temperature patterns associated with climate change. Reporting rates for other potentially water-borne zoonoses are also noticeable (for example, the reported rate for cryptosporidiosis for 2011 was 14 per 100,000 population). The distribution of Cryptosporidium oocysts in the environment may be influenced by climate change because it has often been implicated in drinking-water contamination, and heavy rainfall events have been found to be associated with increased pathogen loads in rivers and disease incidence. Given this background, which may also be applicable to other countries with agriculturally-dominated landscapes, a New Zealand study was initiated to develop a decision-support system for the projected effects of climate change on a selected suite of environmentally-transmitted pathogens, including Campylobacter and Cryptosporodium oocysts. Herein we report on the manner in which a linear SIR (Susceptible-Ill-Recovered) model previously developed for campylobacteriosis can be extended to cryptosporidiosis, applied to changes in pathogen contact rate and hence reported illness, and coupled to climate change projections associated with different greenhouse gas emission scenarios. The resulting SIR model outputs provided projected

  11. Another Look at a Bahamian Mystery: The Murder of Sir Harry Oakes

    Directory of Open Access Journals (Sweden)

    LeGrand, Cathy

    2010-01-01

    Full Text Available Stop me if you've heard this one:The richest man in the Bahamas, no, the richest man in the British empire, is murdered in his bed. He has suffered a fatal head wound caused by a boat's winch lever. Or by bullets from a small-caliber gun. No, by a conch shell. Or by some blunt object close at hand, still unidentified.The rich man's body is set afire in order to burn down his house and conceal the details of the crime. Or as a diversionary tactic, to confuse the authorities. No, in a voodoo ritual.The killer is his son-in-law. Or his houseguest. Or a mafia hitman.The reason for the murder: to eliminate a powerful opponent of casino gambling. Or to prevent this rich man from leaving the Bahamas with his businesses and wealth. Or to avenge the rich man's resentment of his daughter's choice of husband. Or to steal the enormous horde of gold reported to be hidden in his house.The richest man in the Bahamas (if not the whole Empire was Sir Harry Oakes, who earned his fortune from gold prospecting and spent the rest of his life avoiding the tax man. He was found murdered in the morning of 8 July 1943, having been killed sometime after midnight during a summer thunderstorm. His body, bearing four lethal head wounds and burns from the fire, was discovered the next morning by his close friend and houseguest, Harold Christie, an influential Bahamian estate agent.Add to this cast of characters a smooth-operating Mauritian (Alfred de Marigny married to Oakes' young daughter; a former King of England (the Duke of Windsor, now forced to serve this tiny colonial outpost; and the Duke's scandalous wife (the Duchess of Windsor, for whom he renounced his crown.Also, factor in the war raging around the globe. France had recently fallen to the Nazis; German U-boats patrolled the Atlantic; and the shortages and other exigencies of wartime were the rule. The trial of Alfred deMarigny, Oakes' son-in-law, made international news and his eventual acquittal left the case

  12. Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

    Directory of Open Access Journals (Sweden)

    Luís Gaspar

    2018-01-01

    Full Text Available Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to control the disease. Sirtuins, also called Silent information regulator 2 (Sir2 proteins have long been suggested as interesting targets to treat different diseases, including parasitic infections. Recent studies on Trypanosoma cruzi sirtuins have hinted at the possibility to exploit these enzymes as a possible drug targets. In the present work, the T. cruzi Sir2 related protein 1 (TcSir2rp1 is genetically validated as a drug target and biochemically characterized for its NAD+-dependent deacetylase activity and its inhibition by the classic sirtuin inhibitor nicotinamide, as well as by bisnaphthalimidopropyl (BNIP derivatives, a class of parasite sirtuin inhibitors. BNIPs ability to inhibit TcSir2rp1, and anti-parasitic activity against T. cruzi amastigotes in vitro were investigated. The compound BNIP Spermidine (BNIPSpd (9, was found to be the most potent inhibitor of TcSir2rp1. Moreover, this compound showed altered trypanocidal activity against TcSir2rp1 overexpressing epimastigotes and anti-parasitic activity similar to the reference drug benznidazole against the medically important amastigotes, while having the highest selectivity index amongst the compounds tested. Unfortunately, BNIPSpd failed to treat a mouse model of Chagas disease, possibly due to its pharmacokinetic profile. Medicinal chemistry modifications of the compound, as well as alternative formulations may improve activity and pharmacokinetics in the future. Additionally, an initial TcSIR2rp1 model in complex with p53 peptide substrate was obtained from low resolution X-ray data (3.5 Å to

  13. BET 2: Can procalcitonin accurately diagnose serious bacterial infection in emergency department patients with SIRS?

    Science.gov (United States)

    Wilson, Joel; Baskerville, Jerry; Zarabi, Sahar

    2017-09-01

    A shortcut review was carried out to establish whether serum procalcitonin levels can be used to identify serious bacterial infection in ED patients with undifferentiated SIRS. 14 papers presented the best evidence to answer the clinical question. The review concludes that raised procalcitonin levels are associated with bacteraemia; however, there are no clinical management studies addressing this question in ED patients with SIRS. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Sir William Henry Perkin: The Man and his 'Mauve'

    Indian Academy of Sciences (India)

    Senior Perkin used to get copies of building plans made by. William with the intention, in addition to using his drawing skill, to influence William to take up .... with it for the dye soared making the business of Perkin & Sons. 1. 1 In the Classics Section (p.856), the details of the patent applica- tion including the procedure for.

  15. Mitochondria-Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS).

    Science.gov (United States)

    Zakharova, Vlada V; Pletjushkina, Olga Yu; Zinovkin, Roman A; Popova, Ekaterina N; Chernyak, Boris V

    2017-05-01

    Systemic inflammatory response syndrome (SIRS) development is accompanied by mitochondrial dysfunction and excessive ROS production. Mitochondrial dysfunctions also occur in many SIRS-related diseases and may be critical for their pathogenesis; therefore, a use of mitochondria-targeted drugs is a promising trend in SIRS research and therapy. Here, we review recent studies concerning the application of the mitochondria-targeted antioxidants and uncouplers of oxidative phosphorylation in animal models of SIRS and related diseases. We propose that a new class of uncouplers of oxidative phosphorylation, lipophilic cations could be a base for a new generation of drugs for SIRS treatment. J. Cell. Physiol. 232: 904-912, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  16. PET/CT Biograph trademark Sensation 16. Performance improvement using faster electronics

    International Nuclear Information System (INIS)

    Martinez, M.J.; Schwaiger, M.; Ziegler, S.I.; Bercier, Y.

    2006-01-01

    Aim: the new PET/CT biograph sensation 16 (BS16) tomographs have faster detector electronics which allow a reduced timing coincidence window and an increased lower energy threshold (from 350 to 400 keV). This paper evaluates the performance of the BS16 PET scanner before and after the Pico-3D electronics upgrade. Methods: four NEMA NU 2-2001 protocols, (i) spatial resolution, (ii) scatter fraction, count losses and random measurement, (iii) sensitivity, and (iv) image quality, have been performed. Results: a considerable change in both PET count-rate performance and image quality is observed after electronics upgrade. The new scatter fraction obtained using Pico-3D electronics showed a 14% decrease compared to that obtained with the previous electronics. At the typical patient background activity (5.3 kBq/ml), the new scatter fraction was approximately 0.42. The noise equivalent count-rate (R NEC ) performance was also improved. The value at which the R NEC curve peaked, increased from 3.7 . 10 4 s -1 at 14 kBq/ml to 6.4 . 10 4 s -1 at 21 kBq/ml (2R-NEC rate). Likewise, the peak true count-rate value increased from 1.9 . 10 5 s -1 at 22 kBq/ml to 3.4 . 10 5 s -1 at 33 kBq/ml. An average increase of 45% in contrast was observed for hot spheres when using AW-OSEM (4ix8s) as the reconstruction algorithm. For cold spheres, the average increase was 12%. Conclusion: the performance of the PET scanners in the BS16 tomographs is improved by the optimization of the signal processing. The narrower energy and timing coincidence windows lead to a considerable increase of signal-to-noise ratio. The existing combination of fast detectors and adapted electronics in the BS16 tomographs allow imaging protocols with reduced acquisition time, providing higher patient throughput. (orig.)

  17. Comparative evaluation of two commercial PET scanners, ECAT EXACT HR+ and Biograph 2, using GATE

    International Nuclear Information System (INIS)

    Karakatsanis, N.; Sakellios, N.; Tsantilas, N.X.; Dikaios, N.; Tsoumpas, C.; Lazaro, D.; Loudos, G.; Schmidtlein, C.R.; Louizi, K.; Valais, J.; Nikolopoulos, D.; Malamitsi, J.; Kandarakis, J.; Nikita, K.

    2006-01-01

    Geant4 application for tomographic emission (GATE) is a generic Monte Carlo simulation platform based on a general-purpose code GEANT4 and designed to simulate positron emission tomography (PET) and single photon emission tomography systems. Monte Carlo simulations are used in nuclear medicine to model imaging systems and develop and assess tomographic reconstruction algorithms and correction methods for improved image quantification. The purpose of this study is to validate two GATE models of the commercial available PET scanner HR+ and the PET/CT Biograph 2. The geometry of the system components has been described in GATE, including detector ring, crystal blocks, PMTs etc. The energy and spatial resolution of the scanners as given by the manufacturers have been taken into account. The GATE simulated results are compared directly to experimental data obtained using a number of NEMA NU-2-2001 performance protocols, including spatial resolution, sensitivity and scatter fraction. All the respective phantoms are precisely modeled. Furthermore, an approximate dead-time model both at the level of single and coincidence events was developed so that the simulated count rate curve can satisfactorily match the experimental count rate performance curve for each scanner In addition a software tool was developed to build the sinograms from the simulated data and import them into the software for tomographic image reconstruction where the reconstruction algorithm of FBP3DRP was applied. An agreement of less than 0.8 mm was obtained between the spatial resolution of the simulated system and the experimental results. Also the simulated scatter fraction for the NEMA NU 2-2001 scatter phantom matched the experimental results to within 3% of measured values. Finally the ratio of the simulated sensitivities with sources radially offset 0 and 10 cm from the central axis of each of the two scanners reaches an agreement of less than 1% between the simulated and experimental values. This

  18. We are not the same people we used to be: An exploration of family biographical narratives and identity change following traumatic brain injury.

    Science.gov (United States)

    Whiffin, Charlotte Jane; Ellis-Hill, Caroline; Bailey, Christopher; Jarrett, Nikki; Hutchinson, Peter J

    2017-10-26

    Subjective changes are increasingly recognised as important in recovery and rehabilitation following traumatic brain injury. Accumulation of subjective changes over time has led many to examine the question of "continuity of self" post-injury. Vacillation between feeling the same and different is common and often at odds with the medical narrative preparing families for permanent change. This position of ambiguity was examined in a qualitative narrative study. The aim of this paper is to describe the narrative structures used by uninjured members of a family to understand change. These changes relate primarily, to their perspective of whether and how the injured person had changed, but also secondarily to whether and why they themselves felt they had changed in the first year post-injury. Nine uninjured family members from three families took part in three unstructured interviews during the first twelve months post-injury. In-depth narrative analysis showed family members used biographical attendance; biographical disruption; biographical continuity; and biographical reconstruction to understand change. Drawing on these findings it is argued that concentrating on a narrative of change is too limiting and that engaging in biographical narratives may help humanise care provided to injured individuals and their families. Implications for research and practice are discussed.

  19. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

    Science.gov (United States)

    Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

    2012-09-01

    FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

  20. Correlation between IL-6 levels and the systemic inflammatory response score: can an IL-6 cutoff predict a SIRS state?

    Science.gov (United States)

    Giannoudis, Peter V; Harwood, Paul John; Loughenbury, Peter; Van Griensven, Martijn; Krettek, Christian; Pape, Hans-Christoph

    2008-09-01

    Recently, increasing emphasis is being placed upon assessment of the inflammatory status of the patient. Serum inflammatory cytokines, particularly IL-6, have been used as an adjunct to this assessment. Another method uses a combination of simple laboratory and clinical data to provide an assessment of the patient's current level of systemic inflammation, the SIRS. The aim of this study was to investigate, in a group of adult trauma patients, the relationship between the interleukin-6 (IL-6) concentration, the systemic inflammatory response score (SIRS) and outcome. In patients with femoral shaft fracture, serum IL-6 levels and clinical parameters were recorded prospectively on admission and on days 1, 3, 5, and 7. Clinical course, the SIRS score and complications were documented. Nonparametric tests were used to assess relationships between variables and receiver operator characteristic (ROC) curves were used to examine their predictive values. Significance was assumed at the p SIRS state" detected early (day 1 and 3) positively correlated with the IL-6 measurement from the same period (p SIRS state (p SIRS state with an 83% sensitivity and a 75% specificity (area under ROC curve 0.76, p SIRS state and an IL-6 > 300 pg/mL was associated with a significantly increased risk of complication (pneumonia, MOF, death). Both systems were found to be significantly diagnostic of these complications using ROC curve analysis. The IL-6 concentration and SIRS score are useful adjuncts to clinical evaluation of the injured patient. In the early phase, they are closely correlated with the NISS and each other. A cutoff value of 200 pg/dL was shown to be significantly diagnostic of a SIRS state. Significant correlations between adverse events and both the IL-6 level and SIRS state are demonstrated.

  1. GE~L ~4J SIR HE~R Y TI~SO~ LUKI~

    African Journals Online (AJOL)

    GE~L ~4J SIR HE~R Y TI~SO~ LUKI~. Herkoms en Jeugjare. Fulham is 'n voorstad van Londen. Oit is daar waar Henry Timson Lukin op 24 Mei 1860 as die oudste en enigste seun van Robert Henry. Lukin gebore is. Alhoewel 'n gekwalifiseerde advokaat wat daarby talle oorsese ekspedisies onderneem het, het Robert ...

  2. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

    KAUST Repository

    Korobeinikov, Andrei

    2013-01-01

    We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

  3. Sir Alex Fergusons otte ledelsesprincipper – tilfører de ledelsesdisciplinen nye indsigter?

    DEFF Research Database (Denmark)

    Agger Nielsen, Jeppe

    2015-01-01

    Fodbold og (offentlig) ledelse har umiddelbart ikke mange fællestræk, men der er måske inspiration at hente fra en af de mest anerkendte fodboldmanagers gennem tiden. I hvert fald er Sir Alex Fergusons ledelsesformular blevet en del af pensum på Harvard Business School. Men giver det virkelig god...

  4. George Peabody and the Search for Sir John Franklin, 1852-1854.

    Science.gov (United States)

    Parker, Franklin

    1994-01-01

    One of several articles on educational philanthropist George Peabody focuses on his contribution to the Arctic search for Sir John Franklin, British explorer. Peabody's financial contribution made Elisha Kent Kane's Arctic expedition possible and supported the United States in joining other nations to further scientific development and…

  5. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

    DEFF Research Database (Denmark)

    Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

    2007-01-01

    Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

  6. Fathers' Role as Attachment Figures: An Interview with Sir Richard Bowlby

    Science.gov (United States)

    Newland, Lisa A.; Coyl, Diana D.

    2010-01-01

    Sir Richard Bowlby, son of John Bowlby, has carried on his father's work by lecturing and writing on the topic of attachment theory. He has initiated and maintained international connections with researchers, practitioners and agencies in the field of child development, and has produced training videos to more widely disseminate information about…

  7. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  8. A biomarker panel to discriminate between systemic inflammatory response syndrome SIRS and sepsis and sepsis severity

    NARCIS (Netherlands)

    Punyadeera, C.; Schneider, E. M.; Schaffer, D.; Hsu, H-Y.; Joos, T.O.; Kriebel, F; Weiss, M.; Verhaegh, W.F.J.

    2009-01-01

    In this study we report on initial efforts to discover putative biomarkers for differential diagnosis of a systemic inflammatory response syndrome (SIRS) vs. sepsis; and different stages of sepsis. In addition, we also investigated whether there are proteins that can discriminate between patients

  9. Periodic solution of a stochastic SIRS epidemic model with seasonal variation.

    Science.gov (United States)

    Jin, Manli; Lin, Yuguo

    2018-12-01

    In this paper, we consider a stochastic SIRS epidemic model with seasonal variation and saturated incidence. Firstly, we obtain the threshold of stochastic system which determines whether the epidemic occurs or not. Secondly, we prove that there is a non-trivial positive periodic solution if [Formula: see text].

  10. Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS.

    Science.gov (United States)

    Shaw, Andrew D; Raghunathan, Karthik; Peyerl, Fred W; Munson, Sibyl H; Paluszkiewicz, Scott M; Schermer, Carol R

    2014-12-01

    Recent data suggest that both elevated serum chloride levels and volume overload may be harmful during fluid resuscitation. The purpose of this study was to examine the relationship between the intravenous chloride load and in-hospital mortality among patients with systemic inflammatory response syndrome (SIRS), with and without adjustment for the crystalloid volume administered. We conducted a retrospective analysis of 109,836 patients ≥ 18 years old that met criteria for SIRS and received fluid resuscitation with crystalloids. We examined the association between changes in serum chloride concentration, the administered chloride load and fluid volume, and the 'volume-adjusted chloride load' and in-hospital mortality. In general, increases in the serum chloride concentration were associated with increased mortality. Mortality was lowest (3.7%) among patients with minimal increases in serum chloride concentration (0-10 mmol/L) and when the total administered chloride load was low (3.5% among patients receiving 100-200 mmol; P SIRS, a fluid resuscitation strategy employing lower chloride loads was associated with lower in-hospital mortality. This association was independent of the total fluid volume administered and remained significant after adjustment for severity of illness, supporting the hypothesis that crystalloids with lower chloride content may be preferable for managing patients with SIRS.

  11. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    Science.gov (United States)

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

  12. The Systemic Inflammatory Response Syndrome (SIRS)--number and type of positive criteria predict interventions and outcomes in acute surgical admissions.

    Science.gov (United States)

    Stephenson, James A; Gravante, Gianpiero; Butler, Nicholas A; Sorge, Roberto; Sayers, Rob D; Bown, Matt J

    2010-11-01

    Systemic inflammatory response syndrome (SIRS) is a syndrome that reflects the widespread activation of inflammatory pathways. The goal of this study was to find whether the presence or absence of SIRS on emergency surgical admissions is related to the subsequent clinical outcome in terms of in-hospital interventions, length of stay, and mortality. The presence of SIRS at admission, final diagnosis of the underlying disease, treatments, and clinical outcomes were prospectively recorded for 1 month. Comparisons of interventions and outcomes were performed between SIRS+ vs. SIRS- patients. In patients with SIRS, the contribution of each positive criterion was evaluated with regards to mortality. A total of 179 patients were recruited. The prevalence of SIRS at admission was 35.2%. SIRS+ patients required less diagnostic procedures compared with SIRS- (28.6% vs. 34.5%) but had more therapeutic interventions (39.7% vs. 16.4%), surgical interventions (33.3% vs. 3.4%), intensive treatments (11.1% vs. 0.9%; p SIRS+ patients with four positive criteria had more surgical interventions, intensive treatments, and fatal outcomes compared with the others. Of importance the most influent factor was the respiratory rate followed by the white cell count and the heart rate/temperature. Patients with SIRS at admission apparently receive more interventions, have longer length of stay, and increased mortality than those patients without SIRS. These findings require separate validation in a larger cohort study.

  13. SIRS Digues 2.0: A Cooperative Software For Levees Management

    Directory of Open Access Journals (Sweden)

    Moins Isabelle

    2016-01-01

    Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

  14. Soluble Immune Response Suppressor (SIRS): Reassessing the immunosuppressant potential of an elusive peptide.

    Science.gov (United States)

    Webb, David R

    2016-10-01

    A previously studied immunosuppressive cytokine, Soluble Immune Response Suppressor (SIRS), may have relevance to current studies of immune suppression in a variety of human disease states. Despite extensive efforts using experimental models, mainly in mice, much remains to be discovered as to how autoimmune cells in mice and humans escape normal regulation and, conversely, how tumor cells evade evoking an immune response. It is the contention of this commentary that the literature pre-2000 contain results that might inform current studies. The broadly immunosuppressive protein, SIRS, was studied extensively from the 1970s to 1990s and culminated in the determination of the n-terminal 21mer sequence of this 15kDa protein which had high homology to the short neurotoxins from sea snakes, that are canonical members of the three finger neurotoxin superfamily (3FTx). It was not until 2007 that the prophylactic administration of the synthetic N-terminal peptide of the SIRS 21mer, identical to the published sequence, was reported to inhibit or delay the development of two autoimmune diseases in mice: experimental allergic encephalomyelitis (EAE) and type I diabetes (T1D). These findings were consistent with other studies of the 3FTx superfamily as important probes in the study of mammalian pharmacology. It is the perspective of this commentary that SIRS, SIRS peptide and the anti-peptide mAb, represent useful, pharmacologically-active probes for the study of the immune response as well as in the potential treatment of autoimmune, inflammatory diseases and cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Treatment of post-cardiopulmonary bypass SIRS by hemoadsorption: a case series.

    Science.gov (United States)

    Träger, Karl; Fritzler, Daniel; Fischer, Guenther; Schröder, Janpeter; Skrabal, Christian; Liebold, Andreas; Reinelt, Helmut

    2016-05-16

    The use of cardiopulmonary bypass (CPB) in cardiothoracic surgery results in a well-known activation of the immunologic response. In some cases, however, this triggered immunologic response may be excessive, leading to a severe systemic inflammatory response syndrome (SIRS) and induced organ dysfunction. For example, patients frequently develop hemodynamic instability with hypotension and low systemic vascular resistance. To date, different therapeutic approaches, such as steroids, have been tried to control this maladaptive postoperative SIRS response, yet definitive proof of clinical efficacy is missing. A new cytokine adsorber device (CytoSorb; CytoSorbents) may be a useful approach to control hyperinflammatory systemic reactions by reducing a broad range of proinflammatory cytokines and other inflammatory mediators. This may, in turn, help to reestablish a physiologic immune response and help to restore deranged clinical parameters in these patients. In this retrospective case series study, we describe 16 cardiac surgery patients following prolonged CPB with post-CPB SIRS and subsequent acute kidney injury, who were then treated with hemoadsorption using CytoSorb in combination with continuous renal replacement therapy (CRRT). Treatment of patients with CytoSorb who presented with severe post-CPB SIRS resulted in a reduction of elevated cytokine levels, which was associated with a clear stabilization of deranged hemodynamic, metabolic, and organ function parameters. Treatment was well tolerated and safe, with no device-related adverse events occurring. CytoSorb therapy combined with CRRT is a potentially promising new treatment approach to achieve hemodynamic stability, cytokine reduction, and improved organ function in cardiac surgery patients who develop post-CPB SIRS.

  16. Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

    Directory of Open Access Journals (Sweden)

    Christian eLinke

    2013-07-01

    Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

  17. Use of SIR-B multiincidence-angle imagery to study iceberg detectability and offshore ocean feature extraction

    Science.gov (United States)

    Gray, A. L.; Princz, J.; Livingstone, C. E.; Hawkins, R. K.; Wong, M.; Pearson, D.; Gower, J.; Mullane, T. F.; Ramseier, R. O.

    1984-01-01

    The Shuttle Imaging Radar B (SIR-B) iceberg experiment is described and expected results are outlined. The specific objectives are: (1) to study the L-band satellite SAR detectability of iceberg targets as a function of incidence angle and observed conditions; (2) to compare L-, X-, and C-band aircraft imagery, and to use this data as a basis for an appropriate simulation of satellite imagery and to compare with SIR-B images; and (3) to determine the possibility of comparive available surface or near surface currents with estimates of the range component of surface current derived from the SIR-B data (IOS experiment).

  18. Return to the far side of planet Moore! rambling through observations, friendships and antics of sir Patrick Moore

    CERN Document Server

    Mobberley, Martin

    2015-01-01

    The result of an exhaustive study of Sir Patrick Moore’s observations of the Moon and planets for more than 60 years, this book is a fantastic companion to the extremely popular, “It Came From Outer Space Wearing an RAF Blazer!” written by the same author.  Moore recorded his telescopic observations in his logbooks, which are reproduced and described here in detail, along with his sketches and notes. In this light, the author discusses the factors that caused Moore to switch from lunar observing to planetary and variable star observing.  He has also included personal recollections and humorous anecdotes from Moore’s friends and acquaintances, as well as a look at his best loved books. Further chapters describe Moore’s foreign travels and correspondence with those back home. Lastly, the author has not neglected a few of Moore’s most memorable television and radio appearances, which are examined along with a close up of what it was like to visit Moore’s beloved home of Farthings in Selsey. Essen...

  19. Main: Clone Detail [KOME

    Lifescience Database Archive (English)

    Full Text Available Clone Detail Mapping Pseudomolecule data detail Detail information Mapping to the T...IGR japonica Pseudomolecules kome_mapping_pseudomolecule_data_detail.zip kome_mapping_pseudomolecule_data_detail ...

  20. Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

    Science.gov (United States)

    Carrera, Mónica; Gallardo, José M

    2017-02-08

    The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

  1. Compact Diplexer with High Isolation and Wide Stopband Based on SIRs

    Science.gov (United States)

    Zhou, Bo; Wang, Xin-Yi; Wei, Feng; Chen, Lei

    2017-05-01

    A compact microstrip diplexer with a high isolation and improved out-of-band performance is proposed in this paper. The proposed diplexer is based on cascaded-quadruplet (CQ) bandpass filters (BPFs), which is composed of λ/4 stepped-impedance resonators (SIRs). By employing the edge and quasi-lumped coupling topology, a compact diplexer with improved passband selectivity can be achieved. Meanwhile, by appropriately adjusting the impedance and electric length ratios of SIRs, the stopband can be extended to 20 GHz with a rejection level of 10 dB, which is 12.7 times of the fundamental frequency. The predicted results on S parameters are compared with the measured ones and good agreement is achieved.

  2. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

    Directory of Open Access Journals (Sweden)

    Caitlin R. Ondracek

    2017-03-01

    Full Text Available Sirtuin enzymes depend on NAD+ to catalyze protein deacetylation. Therefore, the lowering of NAD+ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD+-depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD+-limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms.

  3. Global analysis of multi-strains SIS, SIR and MSIR epidemic models

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2014-01-01

    International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

  4. Competitive exclusion principle for SIS and SIR models with n strains

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2012-01-01

    We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

  5. Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

    Directory of Open Access Journals (Sweden)

    Junhong Li

    2013-01-01

    Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

  6. Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

    Directory of Open Access Journals (Sweden)

    Elke eBloem

    2015-01-01

    Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  7. Mathematical models of SIR disease spread with combined non-sexual and sexual transmission routes

    OpenAIRE

    Joel C. Miller

    2017-01-01

    The emergence of Zika and Ebola demonstrates the importance of understanding the role of sexual transmission in the spread of diseases with a primarily non-sexual transmission route. In this paper, we develop low-dimensional models for how an SIR disease will spread if it transmits through a sexual contact network and some other transmission mechanism, such as direct contact or vectors. We show that the models derived accurately predict the dynamics of simulations in the large population limi...

  8. Periodic solution and stationary distribution of stochastic SIR epidemic models with higher order perturbation

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing; Hayat, Tasawar; Ahmad, Bashir

    2017-09-01

    In this paper, we investigate two stochastic SIR epidemic models with higher order perturbation. For the nonautonomous periodic case of the model, by using Has'minskii's theory of periodic solution, we show that the system has at least one nontrivial positive T-periodic solution. For the system disturbed by both the white noise and telephone noise, we establish sufficient conditions for positive recurrence and the existence of ergodic stationary distribution of the positive solution.

  9. Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

    Science.gov (United States)

    Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

    2018-01-01

    This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

  10. A class of stochastic delayed SIR epidemic models with generalized nonlinear incidence rate and temporary immunity

    Science.gov (United States)

    Fan, Kuangang; Zhang, Yan; Gao, Shujing; Wei, Xiang

    2017-09-01

    A class of SIR epidemic model with generalized nonlinear incidence rate is presented in this paper. Temporary immunity and stochastic perturbation are also considered. The existence and uniqueness of the global positive solution is achieved. Sufficient conditions guaranteeing the extinction and persistence of the epidemic disease are established. Moreover, the threshold behavior is discussed, and the threshold value R0 is obtained. We show that if R0 1, then the system remains permanent in the mean.

  11. The Sex Differences of Morphology and Immunology of SIRS of Newborn Wistar Rats.

    Science.gov (United States)

    Kosyreva, A M

    2014-01-01

    The sex differences of infection and inflammatory diseases particularly appear at reproductive age and depend on the sex hormone level, varied between male and female. There are a few sets of data about the sex differences of infection and inflammatory diseases course, including systemic inflammatory response syndrome (SIRS) and sepsis, of newborns. The aim of our research was the estimation of morphological and immunological manifestation of SIRS of the newborn Wistar rats. Investigations were carried out on male and female two-day-old Wistar rats (10-12 g). SIRS was modeled by intraperitoneal injection of LPS (E. coli, O26: B6 strain, Sigma) in high dose-15 mg/kg. We did not find out any sex differences of the liver lesions severity between newborn males and females after LPS injection. The levels of endotoxin and estradiol in the serum, as the number of neutrophils in the intra-alveolar septa of the lungs, were higher in males than females with SIRS. Production of IL-2 and TNF-α by the spleen cells of males was higher than that in control group that reflects polarization predominantly on the Th1-type immune response. The secretion of IL-2, TNF-α, and IFN-γ by ConA activated spleen cells of females decreased that reflects the suppression of Th1-type immune response. We suppose that the LPS administration in the high dose causes the multidirectional reaction of the immune system of neonatal males and females Wistar rats.

  12. SIRS is valid in discriminating between severe and moderate diabetic foot infections.

    Science.gov (United States)

    Wukich, Dane K; Hobizal, Kimberlee B; Raspovic, Katherine Marie; Rosario, Bedda L

    2013-11-01

    This retrospective, single-center study was designed to distinguish severe diabetic foot infection (DFI) from moderate DFI based on the presence or absence of systemic inflammatory response syndrome (SIRS). The database of a single academic foot and ankle program was reviewed and 119 patients were identified. Severe DFI was defined as local infection associated with manifestation of two or more objective findings of systemic toxicity using SIRS criteria. Patients with severe DFI experienced a 2.55-fold higher risk of any amputation (95% CI 1.21-5.36) and a 7.12-fold higher risk of major amputation (1.83-41.05) than patients with moderate DFI. The risk of minor amputations was not significantly different between the two groups (odds ratio 1.02 [95% CI 0.51-2.28]). The odds of having a severe DFI was 7.82 times higher in patients who presented with gangrene (2.03-44.81) and five times higher in patients who reported symptoms of anorexia, chills, nausea, or vomiting (2.22-11.25). The mean hospital length of stay for patients with severe DFI was ∼4 days longer than for patients with moderate DFI, and this difference was statistically significant. SIRS is valid in distinguishing severe from moderate DFI in hospitalized patients. Patients with severe DFI, as by manifesting two or more signs of systemic inflammation or toxicity, had higher rates of major amputation and longer hospital stays and required more surgery and more subsequent admissions than patients who did not manifest SIRS.

  13. SIrD: A Software Describing a System of Identification for Drosophilidae

    OpenAIRE

    Jessie G. Gorospe; Mark Anthony J. Torres; Rez A. Cabrera; Glaiza G. Opema; Cesar G. Demayo

    2013-01-01

    The power of computers have enabled the field of biology to make significant leaps in quantitative methods. Fresh ideas from other disciplines in science and technology offer insight on how old techniques can be evolved into new ones for the benefit of biologists worldwide. In this study, a different approach to Drosophila species identification is presented by making use of binary coding and computer automation. The developed software, a System of Identification for Drosophilidae (SIrD...

  14. The design and development of two-failure tolerant mechanisms for the Spaceborne Imaging Radar (SIR-B) antenna

    Science.gov (United States)

    Presas, S. J.

    1984-01-01

    The performance requirements, design constraints, and design qualification status of the mechanisms necessary to restrain, deploy, and stow the Spaceborne Imaging Radar (SIR) B antenna experiment on the Shuttle Orbiters are described.

  15. Mitochondrial DNA is Released in Urine of SIRS Patients With Acute Kidney Injury and Correlates With Severity of Renal Dysfunction

    NARCIS (Netherlands)

    Jansen, Marcel P. B.; Pulskens, Wilco P.; Butter, Loes M.; Florquin, Sandrine; Juffermans, Nicole P.; Roelofs, Joris J. T. H.; Leemans, Jaklien C.

    2018-01-01

    Systemic inflammatory response syndrome (SIRS) is characterized by the activation of the innate immune system resulting in stimulation of inflammatory responses, coagulation, and platelet activation that may contribute to complication such as the development of acute kidney injury (AKI). AKI

  16. COMETS Profiles. Career Oriented Modules to Explore Topics in Science. 24 Biographical Sketches of Women in Science Careers plus Accompanying Language Arts Activities.

    Science.gov (United States)

    Noyce, Ruth, Ed.

    Twenty-four biographical sketches of women in scientific professions are included in this COMETS Profiles package. Each biography relates to a science topic dealt with in one of the instructional modules of COMETS Science (Career Oriented Modules to Explore Topics in Science). The purpose of these materials is to demonstrate to early adolescents…

  17. Biography and Story in Sociological Analysis. The Contribution of the BNIM (Biographic-Narrative Interpretive Method School

    Directory of Open Access Journals (Sweden)

    Eugenia Cardenal

    2016-01-01

    Full Text Available This paper outlines the epistemological and methodological specificities of the Biographic-Narrative Interpretive Method, developed in Britain (under the name "BNIM" and Germany (where it is known as ?Interpretative Biografi eforschung?. Based on phenomenology and hermeneutics, this method seeks to express subjects? past and present frames of meaning through the use of a non-directive interview. This interview is analysed by a reconstructive process that differentiates between the "lived life" and the "told story", and subsequently connects both dimensions. The main steps for the application of the method are explained through the case study of Adriana, taken from a R&D&i research project on immigration and the labour market.

  18. Recombinant NAD-dependent SIR-2 protein of Leishmania donovani: immunobiochemical characterization as a potential vaccine against visceral leishmaniasis.

    Science.gov (United States)

    Baharia, Rajendra K; Tandon, Rati; Sharma, Tanuj; Suthar, Manish K; Das, Sanchita; Siddiqi, Mohammad Imran; Saxena, Jitendra Kumar; Sundar, Shaym; Sunder, Shyam; Dube, Anuradha

    2015-03-01

    The development of a vaccine conferring long-lasting immunity remains a challenge against visceral leishmaniasis (VL). Immunoproteomic characterization of Leishmania donovani proteins led to the identification of a novel protein NAD+-dependent Silent Information regulatory-2 (SIR2 family or sirtuin) protein (LdSir2RP) as one of the potent immunostimulatory proteins. Proteins of the SIR2 family are characterized by a conserved catalytic domain that exerts unique NAD-dependent deacetylase activity. In the present study, an immunobiochemical characterization of LdSir2RP and further evaluation of its immunogenicity and prophylactic potential was done to assess for its possible involvement as a vaccine candidate against leishmaniasis. LdSir2RP was successfully cloned, expressed and purified. The gene was present as a monomeric protein of ~45 kDa and further established by the crosslinking experiment. rLdSir2RP shown cytosolic localization in L. donovani and demonstrating NAD+-dependent deacetylase activity. Bioinformatic analysis also confirmed that LdSir2RP protein has NAD binding domain. The rLdSir2RP was further assessed for its cellular response by lymphoproliferative assay and cytokine ELISA in cured Leishmania patients and hamsters (Mesocricetus auratus) in comparison to soluble Leishmania antigen and it was observed to stimulate the production of IFN-γ, IL-12 and TNF-α significantly but not the IL-4 and IL-10. The naïve hamsters when vaccinated with rLdSir2RP alongwith BCG resisted the L. donovani challenge to the tune of ~75% and generated strong IL-12 and IFN-γ mediated Th1 type immune response thereof. The efficacy was further supported by remarkable increase in IgG2 antibody level which is indicative of Th1 type of protective response. Further, with a possible implication in vaccine design against VL, identification of potential T-cell epitopes of rLdSir2RP was done using computational approach. The immunobiochemical characterization strongly suggest the

  19. Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

    Science.gov (United States)

    Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

    2017-01-01

    Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  20. Persistent SIRS and acute fluid collections are associated with increased CT scanning in acute interstitial pancreatitis.

    Science.gov (United States)

    Kamal, Ayesha; Faghih, Mahya; Moran, Robert A; Afghani, Elham; Sinha, Amitasha; Parsa, Nasim; Makary, Martin A; Zaheer, Atif; Fishman, Elliot K; Khashab, Mouen A; Kalloo, Anthony N; Singh, Vikesh K

    2018-01-01

    The use of computed tomography (CT) in acute pancreatitis (AP) continues to increase in parallel with the increasing use of diagnostic imaging in clinical medicine. To determine the factors associated with obtaining >1 CT scan in acute interstitial pancreatitis (AIP). Demographic and clinical data of all adult patients admitted between 1/2010 and 1/2015 with AP (AP) were evaluated. Only patients with a CT severity index (CTSI) ≤ 3 on a CT obtained within 48 h of presentation were included. A total of 229 patients were included, of whom 206 (90%) had a single CT and 23 (10%) had >1 CT during the first week of hospitalization. Patients undergoing >1 CT had significantly higher rates of acute fluid collection (AFC), persistent SIRS, opioid use ≥4 days, and persistent organ failure compared to those undergoing 1 CT (p SIRS (OR = 3.6, 95% CI 1.4-9.6, p = .01) and an AFC on initial CT (OR = 3.5, 95% CI 1.4-9, p = .009) were independently associated with obtaining >1 CT. An AFC on initial CT and persistent SIRS are associated with increased CT imaging in AIP patients. However, these additional CT scans did not change clinical management.

  1. [The effect of Xuebijing injection on immune regulation in SIRS patients].

    Science.gov (United States)

    Zhao, Wei; Li, Kun; Zhang, Song-Song; Fu, Yong-Jian; Shi, Xian-Qing

    2014-09-01

    To investgate the effect of Xuebijing Injection on immune regulation in patients with systemic inflammatory response syndrome (SIRS). 56 SIRS patients admitted to the ICU of Guizhou Provincial Hospital from January 2013 to December 2013 were included in this study. The patients were randomly divided into a control (C) and a treatment (T) group. Patients in C group received routine treatment; while patients in T group received additional Xuebijing Injection 50 mL Bid. The following indicators were recorded and compared between the two groups before and 4 and 7 days after treatments: CD4+, CD8+, CD4+/CD8+, monocytes CD14+/human leukocyte antigen-DR (HLA-DR), score of acute physiology and chronic health evaluation II (APACHE II), heart rate, white blood cells, body temperature, respiration rate, and MODS (7 d after treatment only). No differences were found between the two groups before treatments (P > 0.05). T Group had higher levels of CD4+, CD8, CD4+/CD8+ and monocytes CD14+/HLA-DR than C group at 4 and 7 d after treatments (P 0.05). Xuebijing Injection can regulate immune function of patients with SIRS.

  2. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    International Nuclear Information System (INIS)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-01-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

  3. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  4. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Science.gov (United States)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  5. Thoroughly Post-Modern Mary. A Biographic Narrative Interview With Mary Gergen

    Directory of Open Access Journals (Sweden)

    Kip Jones

    2004-09-01

    Full Text Available Method: The Biographic Narrative Interpretive Method (Prue CHAMBERLAYNE, Joanna BORNAT & Tom WENGRAF, 2000; Tom WENGRAF 2001; Gabriele ROSENTHAL 2004; Kip JONES 2004 uses an interview technique in the form of a single, initial narrative-inducing question (minimalist-passive, for example, "Tell me the story of your life," to elicit an extensive, uninterrupted narration. This shift encompasses willingness on the part of the researcher to cede "control" of the interview scene to the interviewee and assume the posture of active listener/audience participant. A follow-up sub-session can then be used to ask additional questions, but based only on what the interviewee has said in the first interview and using her/his words and phrases in the same order. Through hypothesising how the lived life informs the told story, the case history is then finally constructed from the two separate threads of the "lived life" and the "told story." In this paper, the "lived life" and "told story" are presented in a "raw" form with the further involvement of the reader in mind. The story has not been "analysed" by the interviewer, but left open and transparent. Still, the production of the story becomes the creative output and social construction of both the storyteller and the interviewer (the performer and the audience and, in this case particularly, one story of many stories that could have been told by the person interviewed. Routine facts are often back-grounded by the narrator through the use of this method in favour of spontaneity in the storytelling and the creation of meaningful life metaphors. In this way, the personal journey to "who the interviewee is today" is described, rather than merely a list of accomplishments. The Lived Life: Mary GERGEN (née McCANNEY was born in 1938. The first part of her childhood was spent in the small town of Balaton, Minnesota. She subsequently moved with her family to Minneapolis when she was 12. She attended a suburban middle

  6. Biographical Compilation by as-Safadi Salah al-Din as a Source of the Golden Horde History

    Directory of Open Access Journals (Sweden)

    Zaynuddinov D.R.

    2016-12-01

    Full Text Available Publication and translation into Russian of extracts of sources on the Golden Horde history remains topical issue of contemporary source studies. Research objective: to introduce into academic circulation materials on the Golden Horde history from a previously unknown medieval Arab source. Research materials: Biographical Collection Aʿyān al-ʿAṣrwa-Aʿwān al-Naṣr (Outstanding personalities of this century, and the champions of victory belonging to the pen of the Mamluk historian al-Safadi, Salah al-Din (696 AH / 1297 – 764 GH./1363. Results and novelty of the research: The work was written by the author in Egypt and Syria in the second half of the 14th century, that is, during the heyday of the Golden Horde. It was first published in 1998 in Beirut in six volumes, the latter being composed of indexes. The amount of volume ranges from 685 (Volume 4 to 736 (Vol.1 pages, which makes a total of 3578 pages (without indexes. The novelty of the paper consists in the fact that it introduces for the first time into scholarly circulation Russian translation of biographies of the Golden Horde khans Tokhta and Uzbek, of the Mamluk physician al-Numan, of amir Kusun and Sultan al-Nasir. The article also contains an analysis of the collection as well as translation of certain sections of the work related to the history of Dasht-i Kipchak, together with brief comments. In conclusion, I would like to note that the introduction into the scholarly circulation of Salah al-Din al-Safadi’s biographical collection Aʿyān al-ʿAṣrwa-Aʿwān al-Naṣr will provide a lot of useful information and help to clarify the available data on the history of the Golden Horde.

  7. Biographical disruption, adjustment and reconstruction of everyday occupations and work participation after mild traumatic brain injury. A focus group study.

    Science.gov (United States)

    Sveen, Unni; Søberg, Helene Lundgaard; Østensjø, Sigrid

    2016-11-01

    To explore traumatic brain injury (TBI) as a biographical disruption and to study the reconstruction of everyday occupations and work participation among individuals with mild TBI. Seven focus groups were conducted with 12 women and 8 men (22-60 years) who had sustained mild TBI and participated in a return-to-work program. Interviews were analyzed using qualitative content analysis. Four interrelated themes emerged: disruption of occupational capacity and balance; changes in self-perceptions; experience of time; and occupational adjustment and reconstruction. The meaning of the impairments lies in their impact on the individual's everyday occupations. The abandonment of meaningful daily occupations and the feeling of not recognizing oneself were experienced as threats to the sense of self. Successful integration of the past, present and future was paramount to continuing life activities. The unpredictability of the future seemed to permeate the entire process of adjustment and reconstruction of daily life. Our findings show that the concept of time is important in understanding and supporting the reconstruction of daily life after TBI. The fundamental work of rehabilitation is to ameliorate the disruptions caused by the injury, restoring a sense of personal narrative and supporting the ability to move forward with life. Implications for Rehabilitation Individuals with a protracted recovery after a mild traumatic brain injury must reconstruct a new way of being and acting in the world to achieve biographical continuity. The perceived anxiety regarding changes in self and occupational identity, as well as loss of control over the future, can be attenuated through informational sessions during the hospital stay and at follow-up visits. The significant personal costs of returning to full-time employment too early indicate the need for early and ongoing vocational support in achieving a successful return to work.

  8. SIRS at Admission Is a Predictor of AKI Development and Mortality in Hospitalized Patients with Severe Alcoholic Hepatitis.

    Science.gov (United States)

    Maiwall, R; Chandel, S S; Wani, Z; Kumar, S; Sarin, S K

    2016-03-01

    Systemic inflammatory response syndrome (SIRS) is associated with an increased risk of hepatic encephalopathy, renal failure, and poor outcome in patients with cirrhosis; however, there is a paucity of studies on this entity for severe alcoholic hepatitis (SAH). To evaluate SIRS at baseline as a predictor of development of acute kidney injury (AKI) and mortality in patients with SAH. Consecutive in-patients with SAH (discriminant function ≥ 32) without AKI at baseline were followed up for the development and progression of AKI (AKIN criteria). Of the 365 patients (mean age 45.5 ± 9.5, 356 males), SIRS at baseline was present in 236 (64.6%). AKI developed in 122 (33.4%), of which 50 (40.9%) had progression of AKI. SIRS was associated with bacterial infections in 96 (40.6%) and in 140 (59.3%) occurred in the absence of proven infection microbiologically. The presence of SIRS predicted both AKI development (p SIRS (p = 0.001). High MELD score (p = 0.002, HR 1.1, 95% CI 1.02-1.09), in-hospital progression of AKI (p = 0.04, HR 1.54, 95% CI 1.003-2.38), and SIRS (p = 0.004, HR 1.98, 95% CI 1.25-3.1) were significant predictors of 90-day mortality (model 1), while high MELD score (p SIRS at admission predicts both the development of AKI and 90-day mortality in patients with SAH. This could definitely have a therapeutic and prognostic implication.

  9. Evaluation of usefulness of myeloperoxidase index (MPXI) for differential diagnosis of systemic inflammatory response syndrome (SIRS) in the emergency department.

    Science.gov (United States)

    Cha, Yong Sung; Yoon, Jeong Min; Jung, Woo Jin; Kim, Yong Won; Kim, Tae Hoon; Kim, Oh Hyun; Cha, Kyoung Chul; Kim, Hyun; Hwang, Sung Oh; Lee, Kang Hyun

    2015-04-01

    The myeloperoxidase index (MPXI) is elevated in infection. We ascertained whether MPXI might be useful in differentiation of sepsis versus non-infectious systemic inflammatory response syndrome (SIRS) in emergency department (ED). After exclusion of patients with an age of SIRS (sepsis: 224, 50.3%; and non-infectious SIRS: 220, 49.7%) diagnosed and treated at the ED of The Wonju Severance Christian Hospital from May 2012 to June 2012 were retrospectively reviewed. Median MPXI was higher in sepsis versus non-infectious SIRS (0.1 (IQR: -3.1 to 2.5) vs -1.2 (-4.1 to 1.6), respectively, p=0.020). Median white cell count, neutrophil percentage, C reactive protein level and δ neutrophil index were also higher. However, MPXI resulted as not statistically useful for differential diagnostic parameter in analysis. MPXI is higher in sepsis than in non-infectious SIRS. However, there is currently no evidence that the MPXI adds any additional benefit to differentiate sepsis from non-infectious SIRS in the ED. Therefore, further study will be needed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  10. [Clinical Validation of the Caregiver-Child Socioemotional and Relationship Rating Scale (SIRS) for Child Behavior in a Preschool-Age Sample].

    Science.gov (United States)

    Esins, Svenja; Müller, Jörg Michael; Romer, Georg; Wagner, Katharina; Achtergarde, Sandra

    2017-03-01

    Clinical Validation of the Caregiver-Child Socioemotional and Relationship Rating Scale (SIRS) for Child Behavior in a Preschool-Age Sample The description of child behavior in mother-child-interaction is important in early detection and treatment of psychiatric disorders in preschool children. The Caregiver-Child Socioemotional and Relationship Rating Scale (SIRS) may serve this diagnostic purpose. We aim to examine interrater-reliability of SIRS and concurrent, convergent, and discriminant validity to maternal behavior by Play-PAB, and a measure of mother-child-relationsship by Parent-Infant-Global-Assessment-Scale (PIRGAS). Five raters assessed 47 ten-minute video sequences of parent-child-interaction recorded at the Family Day Hospital for Preschool Children with SIRS, Play-PAB, and PIRGAS. We report psychometric properties of SIRS, and present the association with Play-PAB and PIRGAS. SIRS shows a satisfying interrater-reliability for all items. Positive child behavior e. g. the SIRS' "child responsiveness" shows negative correlation to Play-PAB-scales' parental "hostility" and "intrusiveness", but independence of parental "involvement", "positive emotionality", and "discipline". Child and parental behavior show expected associations with the global relationship measure PIRGAS. The assessment of child behavior in parent-child-interaction with SIRS can be quickly learned and reliably applied without extensive training. SIRS shows meaningful relations to parental behavior and a clinical global measure of the caregiver-child-relationship. We recommend SIRS for clinical diagnostics to describe child behavior in mother-child-interaction.

  11. Sir Humphry Davy and the coal miners of the world: a commentary on Davy (1816) ?An account of an invention for giving light in explosive mixtures of fire-damp in coal mines?

    OpenAIRE

    Thomas, John Meurig

    2015-01-01

    In the period between 1815 and 1818, Sir Humphry Davy read four papers to the Royal Society and published a monograph dealing with a safety lamp for coal miners, all of which record in detail the experimental work that he carried out, with his assistant Michael Faraday, so as to determine how to prevent catastrophic accidents in coal mines by the explosion of fire-damp (methane) in the presence of a naked flame. This article describes the key experiments that he performed at the Royal Institu...

  12. Mitochondrial DNA is Released in Urine of SIRS Patients With Acute Kidney Injury and Correlates With Severity of Renal Dysfunction.

    Science.gov (United States)

    Jansen, Marcel P B; Pulskens, Wilco P; Butter, Loes M; Florquin, Sandrine; Juffermans, Nicole P; Roelofs, Joris J T H; Leemans, Jaklien C

    2018-03-01

    Systemic inflammatory response syndrome (SIRS) is characterized by the activation of the innate immune system resulting in stimulation of inflammatory responses, coagulation, and platelet activation that may contribute to complication such as the development of acute kidney injury (AKI). AKI importantly worsens the outcome of SIRS, implying the existence of a detrimental cross talk via systemic messages. Mitochondria are a source of damage-associated molecular patterns (DAMPs) and are thought to form a molecular link between tissue injury and stimulation of innate immunity. The role of mitochondrial DNA (mtDNA) in the cross talk between the onset of SIRS and subsequent development of AKI is unknown. Hence, we performed a case control study in critically ill patients with SIRS diagnosed with or without AKI, in which we determined mtDNA levels in plasma and urine, and correlated these to markers of renal impairment, inflammation, coagulation, and platelet activation. In addition, we exposed mice, primary renal tubular epithelial cells (TECs), and platelets to mtDNA or purified mitochondrial ligands, and measured their response to elucidate underlying pathophysiological mechanisms. Our data reveal that increased systemic mtDNA levels in SIRS patients do not correlate with systemic inflammation and renal disease activity. Moreover, AKI does not have an additional effect on circulating mtDNA levels. In contrast, we found that urinary mtDNA levels correlate with an elevated albumin creatinine ratio (ACR) as well as with increased urinary markers of inflammation, coagulation, and platelet activation. Both renal TECs and platelets respond to mtDNA and mtDNA ligands, leading to increased expression of, respectively, inflammatory cytokines and P-selectin. Moreover, activation of platelets results in mtDNA release. Together, these data suggest that circulating mtDNA is probably not important in the detrimental cross talk between SIRS and AKI, whereas renal mtDNA accumulation

  13. CLIF-SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis.

    Science.gov (United States)

    Jeong, Jin Hee; Park, In Sung; Kim, Dong Hoon; Kim, Seong Chun; Kang, Changwoo; Lee, Soo Hoon; Kim, Tae Yun; Lee, Sang Bong

    2016-06-01

    Hepatic encephalopathy (HE) is a complication associated with worst prognosis in decompensated liver cirrhosis (LC) patients. Previous studies have identified prognostic factors for HE, and recent studies reported an association between systemic inflammatory response syndrome (SIRS) and liver disease. This study aimed to identify prognostic factors for 30-day mortality in alcoholic LC patients with HE who visited the emergency department (ED).This was a retrospective study of alcoholic LC patients with HE from January 1, 2010, to April 30, 2015. The baseline characteristics, complications of portal hypertension, laboratory values, Child-Pugh class, Model for End-stage Liver Disease (MELD) score, chronic liver failure-sequential organ failure assessment (CLIF-SOFA) score, and SIRS criteria were assessed. The presence of 2 or more SIRS criteria was considered SIRS. The primary outcomes were 30-day mortality and prognostic factors for patients with HE visiting the ED.In total, 105 patients who met the inclusion criteria were analyzed. Overall, the 30-day mortality rate was 6.7% (7 patients).Significant variables were hepatorenal syndrome, international normalized ratio, white blood cell count, total bilirubin level, MELD score CLIF-SOFA score, and SIRS in univariate analysis. CLIF-SOFA score and SIRS were the significant factors in the multivariate analysis (hazard ratio 5.56, 15.98; 95% confidence interval 1.18-26.18, 1.58-161.37; P = 0.03, P = 0.02). The mortality rates differed according to the CLIF-SOFA score (P SIRS in alcoholic LC patients with HE visiting the ED are independent predictors of 30-day mortality.

  14. Spatial resolution and image qualities of Zr-89 on Siemens Biograph TruePoint PET/CT.

    Science.gov (United States)

    Lee, Young Sub; Kim, Jin Su; Kim, Jung Young; Kim, Byung Il; Lim, Sang Moo; Kim, Hee-Joung

    2015-02-01

    Zirconium-89 (t(1/2)=78.41 hours) is an ideal metallic radioisotope for immuno-positron emission tomography (PET), given that its physical half-life closely matches the biological half-life of monoclonal antibodies. In this study, the authors measured the spatial resolution and image quality of Zr-89 PET and compared the results against those obtained using F-18 PET, which is widely regarded as the gold standard for comparison of imaging characteristics. The spatial resolution and image qualities of Zr-89 were measured on the Siemens Biograph Truepoint TrueV PET/CT scanner, partly according to NEMA NU2-2007 standards. For spatial resolution measurement, the Zr-89 point source was located at the center of the axial field of view (FOV) and offset 1/4 axial FOV from the center. For image quality measurements, an NEMA IEC Phantom was used. The NEMA IEC Phantom consists of six hot spheres that were filled with Zr-89 solution. Spatial resolution and image quality (%contrast, %background variability [BV], and source to background ratio [SBR]) were assessed to compare the imaging characteristics of F-18 with those of Siemens Biograph Truepoint TrueV. The transverse and axial spatial resolutions at 1 cm were 4.5 and 4.7 mm for Zr-89, respectively. The %contrast of Zr-89 was 25.5% for the smallest 10 mm sized sphere and 89.8% for the largest 37 mm sized sphere, and for F-18, it was 32.5% for the smallest 10 mm sized sphere and 103.9% for the largest 37 mm sized sphere using the ordered subset expectation maximization (OSEM) reconstruction method. The %BV of F-18 PET was 6.4% for the smallest 10 mm sized sphere and 3.5% for the largest 37 mm sized sphere using the OSEM reconstruction. The SBR of Zr-89 was 1.8 for the smallest 10 mm sized sphere and 3.7 for the largest 37 mm sized sphere, and for F-18, it was 2.0 for the smallest 10 mm sized sphere and 4.1 for the largest 37 mm sized sphere using the OSEM reconstruction method. This study assessed Zr-89

  15. The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

    Science.gov (United States)

    Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

    2010-10-01

    The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

  16. Systemic inflammatory response syndrome (SIRS): where did it come from and is it still relevant today?

    Science.gov (United States)

    Balk, Robert A

    2014-01-01

    The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a variety of other injuries came from a 1991 consensus conference charged with the task of developing an easy-to-apply set of clinical parameters to aid in the early identification of potential candidates to enter into clinical trials to evaluate new treatments for sepsis. There was recognition that a diverse group of injuries produced a common inflammatory response in the host and provided attractive targets for new anti-inflammatory molecules designed to prevent further propagation and/or provide specific treatment. Effective application of these new anti-inflammatory strategies necessitated identification of early clinical markers that could be assessed in real-time and were likely to define a population of patients that would have a beneficial response to the targeted intervention. It was felt that early clinical manifestations might be more readily available to clinicians than more sophisticated and specific assays for inflammatory substances that were systemically released by the network of injurious inflammatory events. Therefore, the early definition of a systemic inflammatory response syndrome (SIRS) was built upon a foundation of basic clinical and laboratory abnormalities that were readily available in almost all clinical settings. With further refinement, it was hoped, that this definition would have a high degree of sensitivity, coupled with a reasonable degree of specificity. This manuscript reviews the derivation, application, utilization, potential benefits, and speculation regarding the future of the SIRS definition.

  17. The Efficacy of Magnesium Sulfate Loading on Microalbuminuria Following SIRS:One Step forward in Dosing

    Directory of Open Access Journals (Sweden)

    Atabak Najafi

    2012-10-01

    Full Text Available Backgrounds:Magnesium has been known for its antioxidative and antiinflammatory properties in many studies. In this study two dosing regimens of magnesium were compared with a placebocontrol group in order to investigate safety and efficacy of high doses of intravenous magnesium sulfate infusion on critically ill trauma patients. Inflammatory and oxidative factors were measured in this trial.Methods:45 trauma patients with systemic inflammatory response syndromes (SIRS were randomly assigned into 2 treatment and one placebo groups. The high dose group received 15 g MgSO4, low dose group received 7.5 g of MgSO4 over 4 hour infusion, and placebo groupreceived saline alone. The initial and post magnesium sulfate injections levels of tumor necrosis factor alpha (TNF-α, total antioxidant power and lipid peroxidation were measured after 6, 18 and 36 hours. The pre-infusion along with 6 and 36 hour level ofmicroalbuminuria were also determined.Results:Repeated measurements illustrated that there was no significant difference in TNF-α, total antioxidant power and lipid peroxidation levels among groups during the period of analysis.The microalbuminuria at 36 hour post infusion of high dose group was lower than that of control group (p = 0.024. Patient’s mortality (28 day was similar among all treatment groups. Both magnesium infusion groups tolerated the drug without experiencing anycomplications.Conclusion:No evidence for antioxidative and antiinflammatory effects of magnesium in traumatic SIRS positive patients was found. Magnesium in high doses may be recommended for traumaticpatients with SIRS status to prevent microalbuminuria.

  18. Procalcitonin fails to predict bacteremia in SIRS patients: a cohort study.

    Science.gov (United States)

    Hoenigl, M; Raggam, R B; Wagner, J; Prueller, F; Grisold, A J; Leitner, E; Seeber, K; Prattes, J; Valentin, T; Zollner-Schwetz, I; Schilcher, G; Krause, R

    2014-10-01

    Procalcitonin (PCT) has previously been proposed as useful marker to rule out bloodstream-infection (BSI). The objective of this study was to evaluate the sensitivity of different PCT cut-offs for prediction of BSI in patients with community (CA)- and hospital-acquired (HA)-BSI. A total of 898 patients fulfilling systemic-inflammatory-response-syndrome (SIRS) criteria were enrolled in this prospective cohort study at the Medical University of Graz, Austria. Of those 666 patients had positive blood cultures (282 CA-BSI, 384 HA-BSI, enrolled between January 2011 and December 2012) and 232 negative blood cultures (enrolled between January 2011 and July 2011 at the emergency department). Blood samples for determination of laboratory infection markers (e.g. PCT) were collected simultaneously with blood cultures. Procalcitonin was significantly (p SIRS patients with bacteremia/fungemia than in those without. Receiver operating characteristic curve analysis revealed an area under the curve (AUC) value of 0.675 for PCT (95% CI 0.636-0.714) for differentiating patients with BSI from those without. AUC for IL-6 was 0.558 (95% CI 0.515-0.600). However, even at the lowest cut-off evaluated (i.e. 0.1 ng/ml) PCT failed to predict BSI in 7% (n = 46) of patients. In the group of patients with SIRS and negative blood culture 79% (n = 185) had PCT levels > 0.1. Procalcitonin was significantly higher in patients with BSI than in those without and superior to IL-6 and CRP. The clinical importance of this is questionable, because a suitable PCT threshold for excluding BSI was not established. An approach where blood cultures are guided by PCT only can therefore not be recommended. © 2014 John Wiley & Sons Ltd.

  19. Divine Doctors: The Construction of the Image of Three Greek Physicians in Islamic Biographical Dictionaries of Physicians

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    Abbou Hershkovits, Keren

    2013-06-01

    Full Text Available This paper examines the way authors of three medieval Islamic biographical dictionaries portrayed the lives, behavior and characteristics of three key figures of Greco-Roman medicine, Asclepius, Hippocrates and Galen. Particular attention was given to the vocabulary and phrasing used in the biographies, and associations with other literary genres or figures. An analysis of these biographies demonstrates a significant resemblance between the portrayal of these Greco-Roman physicians and the lives of prophetic figures in Islam, and especially that of the Prophet Muḥammad. In addition, these biographies align with features attributed to pious Muslims. This study demonstrates that Muslim biographers constructed these biographies as part of a general tendency to associate medicine with Islam, and the origins of medical knowledge with prophetic wisdom. This study mantains that the connotations and use of this particular terminology allows for a positive view of the science of medicine in these Islamic compositions in which they were included.Este artículo analiza la manera en que los autores de tres diccionarios biográficos islámicos medievales retrataron la vida y características de las tres figuras más destacadas de la medicina greco-romana: Asclepio, Hipócrates y Galeno. Se presta especial atención al vocabulario y al estilo empleado en las biografías, así como a su relación con otros géneros literarios o figuras. El análisis de estas biografías revela un considerable parecido entre el retrato de estos tres médicos greco-romanos y la vida de algunos profetas en el Islam, especialmente la del Profeta Muḥammad. Asimismo, estas biografías presentan elementos atribuidos a musulmanes piadosos. Este estudio demuestra que los biógrafos musulmanes construyeron esas biografías como parte de una tendencia general a asociar la medicina con el Islam y los orígenes del saber médico con la sabiduría profética. Igualmente, sostiene que

  20. Threat of biographical disruption: the gendered construction and experience of infertility following cancer for women and men.

    Science.gov (United States)

    Ussher, Jane M; Perz, Janette

    2018-03-05

    Infertility is a major concern for people with cancer and their partners. There have been calls for further research on the gendered nature of psychosocial, emotional and identity concomitants of fertility post-cancer across women and men. The gendered construction and experience of infertility following cancer was examined through a survey of 693 women and 185 men, and in-depth one-to-one interviews with a subsample of survey respondents, 61 women and 17 men, purposively selected across cancer types and age groups. Thematic decomposition was used to examine the open ended survey responses and interviews. The chi square test for independence was used to test for group differences between women and men on closed survey items. In the thematic decomposition, infertility was identified as providing a 'Threat of Biographical Disruption' which impacted on life course and identity, for both women and men. Subthemes identified were: 'Parenthood as central to adulthood'; 'Infertility as a threat to gender identity'; ' Unknown fertility status and delayed parenthood'; 'Feelings of loss and grief'; 'Absence of understanding and support'; 'Benefit finding and renegotiation of identity'. In the closed survey items, the majority of women and men agreed that they had always 'wanted to be a parent' and that 'parenthood was a more important life goal than a satisfying career'. 'It is hard to feel like a true adult until you have a child' and impact upon 'my feelings about myself as a man or a woman' was reported by both women and men, with significantly more women reporting 'I feel empty because of fertility issues'. Many participants agreed they 'could visualise a happy life without a child' and there is 'freedom without children'. Significantly more men than women reported that they had not discussed fertility with a health care professional. The fear of infertility following cancer, or knowledge of compromised fertility, can have negative effects on identity and psychological

  1. Narrative strategies in Sir Philip Sidney’s Astrophil and Stella

    Directory of Open Access Journals (Sweden)

    J. Gouws

    2010-07-01

    Full Text Available In this article I suggest that historically lyric and narrative are not mutually exclusive categories. Focusing on the case of Sir Philip Sidney’s sonnet sequence, “Astrophil and Stella”, I argue that the fundamentally lyric form of the sonnet functions rhetorically and contextually in such a way as to invite narrative construal. I suggest that this is the norm in pre-Enlightenment poetic practice and theory, something which was perhaps occluded by the decline of interest in rhetoric.

  2. Anecdotes to the life and times of Sir Richard Owen (1804-1892) in Lancaster.

    Science.gov (United States)

    Wessels, Q; Taylor, A M

    2017-11-01

    Sir Richard Owen, a Lancastrian, was a prominent biologist, comparative anatomist, geologist, palaeontologist and known for coining the term dinosaur. His expertise in anatomical dissection proved to be one of his biggest assets and aided his career progression at the Royal College of Surgeons and the Zoological Society. Owen's apprenticeship in Lancaster helped him to gain expertise in anatomy and anatomical dissection. The authors aim to provide some novel contextual background to his childhood in Lancaster, his affection for his hometown and his contribution to Lancaster's sanitary reform. The latter aspect of his scientific accomplishments is typically overlooked.

  3. Sir Humphry Davy: boundless chemist, physicist, poet and man of action.

    Science.gov (United States)

    Thomas, Sir John Meurig; Edwards, Peter P; Kuznetsov, Vladimir L

    2008-01-11

    The years 2007 and 2008 mark the bi-centenary of two brilliant discoveries by Sir Humphry Davy: the isolation of sodium and potassium (1807) and the subsequent first observation (1808) of the beautiful blue and bronze colours now known to be characteristic of the solvated electron(1) in potassium-ammonia systems. In celebration of these dazzling discoveries, we reflect on Davy's many extraordinary contributions to science, technology and poetry. Humphry Davy, a truly great man, of Cornish spirit, brought immeasurable benefits to humankind.

  4. Solar Radiometric Data Quality Assessment of SIRS, SKYRAD and GNDRAD Measurements (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Habte, A.; Stoffel, T.; Reda, I.; Wilcox, S.; Kutchenreiter, M.; Gotseff, P.; Anderberg, M.

    2014-03-01

    Solar radiation is the driving force for the earth's weather and climate. Understanding the elements of this dynamic energy balance requires accurate measurements of broadband solar irradiance. Since the mid-1990's the ARM Program has deployed pyrheliometers and pyranometers for the measurement of direct normal irradiance (DNI), global horizontal irradiance (GHI), diffuse horizontal irradiance (DHI), and upwelling shortwave (US) radiation at permanent and mobile field research sites. This poster summarizes the basis for assessing the broadband solar radiation data available from the SIRS, SKYRAD, and GNDRAD measurement systems and provides examples of data inspections.

  5. Effect of infection age on an SIR epidemic model with demography on complex networks

    Science.gov (United States)

    Yang, Junyuan; Chen, Yuming

    2017-08-01

    For the long term population behavior, demography is a very important factor impacting the disease spread. Infection age also helps us better understand the process of the disease transmission. In this paper, we incorporate these two factors in an SIR epidemic model on complex networks. Through mathematical analysis, the basic reproduction number R0 is shown to be a sharp threshold to determine whether or not the disease spreads. Precisely, if R0 is less than 1 then the disease-free equilibrium is globally asymptotically stable while if R0 is larger than 1 then the endemic equilibrium is globally asymptotically stable. Some simulations are carried out to illustrate the theoretical results.

  6. Fonds bibliographique Sir James Reason - Une vie dans l’erreur

    OpenAIRE

    Larouzée, Justin; Guarnieri, Franck

    2015-01-01

    Ce papier de recherche présente la création d’un fonds bibliographique "Sir James Reason". Psychologue anglais, James Reason est mondialement célèbre pour sa taxonomie de l’erreur humaine et son modèle étiologique de l’accident connu sous le nom de Swiss Cheese Model (SCM). Ce Papier de Recherche propose une courte biographie et une explication des principaux fondements des modèles de Reason avant de présenter la liste exhaustive des travaux publiés par Reason

  7. The threshold of a stochastic delayed SIR epidemic model with vaccination

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing

    2016-11-01

    In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

  8. Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study.

    Science.gov (United States)

    Rosa, Regis Goulart; Moraes, Rafael Barberena; Lisboa, Thiago Costa; Schunemann, Daniel Pretto; Teixeira, Cassiano

    We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points). From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n=1175] vs. 68.5% [n=1020], pSIRS ≥2 in predicting need for mechanical ventilation (AUROC=0.64 vs. 0.62, p=0.001), ICU stay>7 days (AUROC=0.65 vs. 0.63, p=0.004), and length of hospitalization >10 days (AUROC=0.61 vs. 0.59, p7 days. Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  9. Accounting for Intimate Partner Violence: A Biographical Analysis of Narrative Strategies Used by Men Experiencing IPV From Their Female Partners.

    Science.gov (United States)

    Corbally, Melissa

    2015-10-01

    Intimate partner violence (IPV) is a serious social issue which affects the medium- and long-term health outcomes of many individuals worldwide. The cost of IPV on the physical and psychological well-being of individuals, in addition to its wider economic costs in responding to abused persons, is significant. Presently, there is a lack of understanding about the nature of female-initiated IPV and how men account for their experiences of it. This study examined male victims' life stories of their IPV experiences from their intimate partners. Using the biographical narrative interpretive method, three cases were analyzed from a social constructionist perspective to examine what narrative strategies men used to account for their experiences of being abused by their female partners. Three dominant narrative strategies were used by respondents: the fatherhood narrative, the good husband narrative, and the abuse narrative. The abuse narrative had a unique narrative form, which reflected respondents' disassociation between their identities as men and also as abused persons. Dominant conflicting discourses of masculinity and intimate partner abuse disadvantaged men in identifying IPV and secondly in responding appropriately. This study found that men prefer to use dominant discursive identities as legitimate means from which to disclose IPV experiences. The findings from this study illustrate that broad questioning by professionals regarding fatherhood may be most helpful in promoting disclosures of IPV if this is suspected. © The Author(s) 2014.

  10. The Integrated Model of (Dys- Functionality: Reconstructing Patterns of Gaming as Self-Medication in Biographical Interviews with Video Game Addicts

    Directory of Open Access Journals (Sweden)

    Paula Bleckmann

    2015-07-01

    Full Text Available We aim to build a new theory of highly committed problematic video gaming based on rich qualitative data and to compare it to existing theories. To do this, we used hermeneutic analytical methods and grounded theory methodology to analyze 125 hours of recording from 42 biographical interviews, 23 of them with long-term follow-up. Participants were addicted (ex- gamers according to screening instruments, aged 16 to 44, 29 males and 13 females. The integrated (dys- functionality model shows in-game behavior of participants to be dysfunctional in that it hinders advancement in several distinguishable real-life biographical quests (for success, for belonging, and for autonomy and at the same time functional in that it matches these quests. The model integrates two seemingly irreconcilable research traditions: The addiction/disease model in medical-psychological research investigates dysfunctionality of gaming in pathological gamers. Game studies focus on functionality of in-game behavior and establish gamer typologies based on gaming motives. By adding the biographical context to game studies, but keeping the gamer's perspective, we show that gamers whose lives become dominated by gaming may know what they want and "virtually" get it, but still not "really" get it in the long term. "Compensatory" gaming does not, thus, equal unproblematic or "non-addicted" gaming. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs150387

  11. Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

    Energy Technology Data Exchange (ETDEWEB)

    Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

    2005-10-07

    Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

  12. Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.

    Directory of Open Access Journals (Sweden)

    Anne Marie Thompson

    Full Text Available Phenotypic plasticity in vascular smooth muscle cells (VSMC is necessary for vessel maintenance, repair and adaptation to vascular changes associated with aging. De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia. As resveratrol has been reported to have cardio- protective effects, we investigated its role in VSMC phenotypic modulation. We demonstrated the novel finding that resveratrol promoted VSMC differentiation as measured by contractile protein expression, contractile morphology and contraction in collagen gels. Resveratrol induced VSMC differentiation through stimulation of SirT1 and AMPK. We made the novel finding that low or high dose resveratrol had an initially different mechanism on induction of differentiation. We found that low dose resveratrol stimulated differentiation through SirT1-mediated activation of AKT, whereas high dose resveratrol stimulated differentiation through AMPK-mediated inhibition of the mTORC1 pathway, allowing activation of AKT. The health effects of resveratrol in cardiovascular diseases, cancer and longevity are an area of active research. We have demonstrated a supplemental avenue where-by resveratrol may promote health by maintaining and enhancing plasticity of the vasculature.

  13. Examination of Soil Moisture Retrieval Using SIR-C Radar Data and a Distributed Hydrological Model

    Science.gov (United States)

    Hsu, A. Y.; ONeill, P. E.; Wood, E. F.; Zion, M.

    1997-01-01

    A major objective of soil moisture-related hydrological-research during NASA's SIR-C/X-SAR mission was to determine and compare soil moisture patterns within humid watersheds using SAR data, ground-based measurements, and hydrologic modeling. Currently available soil moisture-inversion methods using active microwave data are only accurate when applied to bare and slightly vegetated surfaces. Moreover, as the surface dries down, the number of pixels that can provide estimated soil moisture by these radar inversion methods decreases, leading to less accuracy and, confidence in the retrieved soil moisture fields at the watershed scale. The impact of these errors in microwave- derived soil moisture on hydrological modeling of vegetated watersheds has yet to be addressed. In this study a coupled water and energy balance model operating within a topographic framework is used to predict surface soil moisture for both bare and vegetated areas. In the first model run, the hydrological model is initialized using a standard baseflow approach, while in the second model run, soil moisture values derived from SIR-C radar data are used for initialization. The results, which compare favorably with ground measurements, demonstrate the utility of combining radar-derived surface soil moisture information with basin-scale hydrological modeling.

  14. Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

    Directory of Open Access Journals (Sweden)

    Hilary Macartney

    2002-01-01

    Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

  15. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  16. Filtering authentic sepsis arising in the ICU using administrative codes coupled to a SIRS screening protocol.

    Science.gov (United States)

    Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G

    2017-06-01

    Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

    Science.gov (United States)

    Jiao, Jianjun; Cai, Shaohong; Li, Limei

    2016-05-01

    To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

  18. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

    International Nuclear Information System (INIS)

    Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

    2009-01-01

    CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

  19. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.

    Science.gov (United States)

    Banerjee, Kushal Kr; Ayyub, Champakali; Ali, Syed Zeeshan; Mandot, Vinesh; Prasad, Nagaraj G; Kolthur-Seetharam, Ullas

    2012-12-27

    Sir2, an evolutionarily conserved NAD(+)-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2) in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression) in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans. Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.

  20. dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Kushal Kr. Banerjee

    2012-12-01

    Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.