WorldWideScience

Sample records for bioelectricity

  1. Bioelectrics

    CERN Document Server

    Heller, Richard

    2017-01-01

    This book focuses on bioelectrics, a new multidisciplinary field encompassing engineering and biology with applications to the medical, environmental, food, energy, and biotechnological fields. At present, 15 universities and institutes in Japan, the USA and the EU comprise the International Consortium of Bioelectrics, intended to advance this novel and important research field. This book will serve as an introductory resource for young scientists and also as a textbook for use by both undergraduate and graduate students – the world’s first such work solely devoted to bioelectrics.

  2. Bioelectricity and epimorphic regeneration.

    Science.gov (United States)

    Stewart, Scott; Rojas-Muñoz, Agustin; Izpisúa Belmonte, Juan Carlos

    2007-11-01

    All cells have electric potentials across their membranes, but is there really compelling evidence to think that such potentials are used as instructional cues in developmental biology? Numerous reports indicate that, in fact, steady, weak bioelectric fields are observed throughout biology and function during diverse biological processes, including development. Bioelectric fields, generated upon amputation, are also likely to play a key role during vertebrate regeneration by providing the instructive cues needed to direct migrating cells to form a wound epithelium, a structure unique to regenerating animals. However, mechanistic insight is still sorely lacking in the field. What are the genes required for bioelectric-dependent cell migration during regeneration? The power of genetics combined with the use of zebrafish offers the best opportunity for unbiased identification of the molecular players in bioelectricity.

  3. Bioelectrical Perchlorate Remediation

    Science.gov (United States)

    Thrash, C.; Achenbach, L. A.; Coates, J. D.

    2007-12-01

    Several bioreactor designs are currently available for the ex-situ biological attenuation of perchlorate- contaminated waters and recently, some of these reactor designs were conditionally approved by the California Department of Health Services for application in the treatment of perchlorate contaminated drinking water. However, all of these systems are dependent on the continual addition of a chemical electron donor to sustain microbial activity and are always subject to biofouling and downstream water quality issues. In addition, residual labile electron donor in the reactor effluent can stimulate microbial growth in water distribution systems and contribute to the formation of potentially toxic trihalomethanes during disinfection by chlorination. As part of our ongoing studies into microbial perchlorate reduction we investigated the ability of dissimilatory perchlorate reducing bacteria (DPRB) to metabolize perchlorate using a negatively charged electrode (cathode) in the working chamber of a bioelectrical reactor (BER) as the primary electron donor. In this instance the DPRB use the electrons on the electrode surface either directly or indirectly in the form of electrolytically produced H2 as a source of reducing equivalents for nitrate and perchlorate reduction. As part of this investigation our fed-batch studies showed that DPRB could use electrons from a graphite cathode poised at -500mV (vs. Ag/AgCl) for the reduction of perchlorate and nitrate. We isolated a novel organism, Dechlorospirillum strain VDY, from the cathode surface after 70 days operation which readily reduced 100 mg.L-1 perchlorate in a mediatorless batch bioelectrical reactor (BER) in 6 days. Continuous up-flow BERs (UFBERs) seeded with active cultures of strain VDY continuously treated waters containing 100 mg.L-1 perchlorate with almost 100% efficiency throughout their operation achieving a non-optimized volumetric loading of 60 mg.L-1 reactor volume.day-1. The same UFBERs also treated

  4. Bioelectric modulation of macrophage polarization

    Science.gov (United States)

    Li, Chunmei; Levin, Michael; Kaplan, David L.

    2016-02-01

    Macrophages play a critical role in regulating wound healing and tissue regeneration by changing their polarization state in response to local microenvironmental stimuli. The native roles of polarized macrophages encompass biomaterials and tissue remodeling needs, yet harnessing or directing the polarization response has been largely absent as a potential strategy to exploit in regenerative medicine to date. Recent data have revealed that specific alteration of cells’ resting potential (Vmem) is a powerful tool to direct proliferation and differentiation in a number of complex tissues, such as limb regeneration, craniofacial patterning and tumorigenesis. In this study, we explored the bioelectric modulation of macrophage polarization by targeting ATP sensitive potassium channels (KATP). Glibenclamide (KATP blocker) and pinacidil (KATP opener) treatment not only affect macrophage polarization, but also influence the phenotype of prepolarized macrophages. Furthermore, modulation of cell membrane electrical properties can fine-tune macrophage plasticity. Glibenclamide decreased the secretion and gene expression of selected M1 markers, while pinacidil augmented M1 markers. More interestingly, glibencalmide promoted macrophage alternative activation by enhancing certain M2 markers during M2 polarization. These findings suggest that control of bioelectric properties of macrophages could offer a promising approach to regulate macrophage phenotype as a useful tool in regenerative medicine.

  5. Bioelectrical impedance analysis--part I

    DEFF Research Database (Denmark)

    Kyle, Ursula G; Bosaeus, Ingvar; De Lorenzo, Antonio D;

    2004-01-01

    The use of bioelectrical impedance analysis (BIA) is widespread both in healthy subjects and patients, but suffers from a lack of standardized method and quality control procedures. BIA allows the determination of the fat-free mass (FFM) and total body water (TBW) in subjects without significant ...

  6. The inverse problem of bioelectricity: an evaluation

    NARCIS (Netherlands)

    Oosterom, A. van

    2012-01-01

    This invited paper presents a personal view on the current status of the solution to the inverse problem of bioelectricity. Its focus lies on applications in the field of electrocardiography. The topic discussed is also relevant in other medical domains, such as electroencephalography, electroneurog

  7. Bioelectric Applications for Treatment of Melanoma

    Directory of Open Access Journals (Sweden)

    Richard Heller

    2010-09-01

    Full Text Available Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs. EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  8. Bioelectric Applications for Treatment of Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Beebe, Stephen J., E-mail: sbeebe@odu.edu; Schoenbach, Karl H.; Heller, Richard [Frank Reidy Research Center for Bioelectrics/Old Dominion University 4211 Monarch Way, Suite 300, Norfolk, Virginia 23508 (United States)

    2010-09-27

    Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  9. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    Mashhour Mustafa; Bani Amer

    2003-01-01

    This paper deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events. The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers. The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resistors have a larger value. This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors. Moreover, the new designed bioelectric amplifier has an output noise less than that for conventional amplifiers. The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  10. Bioelectrical impedance modelling of gentamicin pharmacokinetic parameters.

    Science.gov (United States)

    Zarowitz, B J; Pilla, A M; Peterson, E L

    1989-10-01

    1. Bioelectrical impedance analysis was used to develop descriptive models of gentamicin pharmacokinetic parameters in 30 adult in-patients receiving therapy with gentamicin. 2. Serial blood samples obtained from each subject at steady state were analyzed and used to derive gentamicin pharmacokinetic parameters. 3. Multiple regression equations were developed for clearance, elimination rate constant and volume of distribution at steady state and were all statistically significant at P less than 0.05. 4. Clinical validation of this innovative technique is warranted before clinical use is recommended.

  11. Biohydrogen, bioelectricity and bioalcohols from cellulosic materials

    Energy Technology Data Exchange (ETDEWEB)

    Nissila, M.

    2013-03-01

    The demand for renewable energy is increasing due to increasing energy demand and global warming associated with increasing use of fossil fuels. Renewable energy can be derived from biological production of energy carriers from cellulosic biomass. These biochemical processes include biomass fermentation to hydrogen, methane and alcohols, and bioelectricity production in microbial fuel cells (MFCs). The objective of this study was to investigate the production of different energy carriers (hydrogen, methane, ethanol, butanol, bioelectricity) through biochemical processes. Hydrogen production potential of a hot spring enrichment culture from different sugars was determined, and hydrogen was produced continuously from xylose. Cellulolytic and hydrogenic cultures were enriched on cellulose, cellulosic pulp materials, and on silage at different process conditions. The enrichment cultures were further characterized. The effect of acid pretreatment on hydrogen production from pulp materials was studied and compared to direct pulp fermentation to hydrogen. Electricity and alcohol(s) were simultaneously produced from xylose in MFCs and the exoelectrogenic and alcohologenic enrichment cultures were characterized. In the end, the energy yields obtained from different biochemical processes were determined and compared. In this study, cultures carrying out simultaneous cellulose hydrolysis and hydrogen fermentation were enriched from different sources at different operational conditions. These cultures were successfully utilized for cellulose to hydrogen fermentation in batch systems. Based on these results further research should be conducted on continuous hydrogen production from cellulosic materials.

  12. [Effects of different electrodes on bioelectrical impedance values].

    Science.gov (United States)

    Nakadomo, F; Tanaka, K; Yokoyama, T; Maeda, K

    1990-01-01

    Effects of different electrodes on bioelectrical impedance values measured by the Selco bioelectrical impedance plethysmograph (SIF-881, Japan) were investigated using 8 adult females (age: 35.3 +/- 7.6 yr, Ht: 156.9 +/- 3.8 cm, Wt: 57.1 +/- 9.9 kg, and hydrodensitometrically determined body fat: 29.4 +/- 6.0%). The Lectec MP3000 electrode (Liberty Carton, USA) and the Bipolar electrode (Sanwa, Japan) produced significantly higher impedance values when compared to the Disposable electrode (Adovance, Japan) and the ECG electrode (Nihon Kohden, Japan). The coefficient of variation was significantly lower for the Disposable electrode (0.8%) and the ECG electrode (0.2%) than that for the Lectec MP3000 electrode (2.3%) and the Bipolar electrode (4.9%). In conclusion, the ECG electrode provides higher bioelectrical impedance values with the highest reproducibility in the assessment of human body composition by the bioelectrical impedance plethysmography.

  13. [Study of bioelectrical properties of acupuncture areas].

    Science.gov (United States)

    Filimon, D V; Zaharia, D; Ciochină, A D; Stratulat, S; Stratone, Ana

    2010-01-01

    The research has as a goal the investigation of the bioelectrical behaviour of the acupunctural areas in order to obtain a scientific substantiation of the correspondence between the extreme--eastern medical tradition and the academical medicine. It is obvious that the Chinese traditional medicine knows a certain mechanism of ensurance of homeostasis of the organisms, a mechanism represented, according to the Chinese medical tradition, by the net of acupuncture points and meridians. The experimental data presented in this paper lead to the discovery of the fact that this net works as the fourth system of integration, the electrical--regulator one. The maintenance of the internal homeostasis of the superior organisms and their adaptation to the environment is ensured by the neuro-endocrine and circulatory systems through a mechanism described by Selye under the name of the Uncertain General Syndrome of Adaptation represented by the hypothalamo-hypophyso-corticoadrenal axis. The evolution of these systems and of their mechanisms can be supervised on the basis of the cortisole concentration. The research emphasized the direct proportionality between the cortisone levels and the variation of the electrical values of the acupuncture points, a fact that demonstrates the involvement of the net of acupuncture points and meridians in the maintenance processes of the homeostasis, control, adjustment and adaptation of the living organisms. Additionally, the analysis of the bioelectrical behavior of the acupuncture areas led to the conclusion that the morpho-functional substrate of this net is the conjunctive tissue. The physical-chemical properties of the interstitial connective tissue assures its working as an electro-regulator system on one side and as a harmonization agent of the neuro-endocrine and circulatory systems on the other side, this aspect being to be developed in a future paper.

  14. Perioperative bioelectrical impedence analysis in neurosurgery.

    Science.gov (United States)

    El-Dawlatly, Abdelazeem A

    2005-10-01

    The use of bioelectrical impedence (BI) measurement to assess body composition has recently attracted the attention of anesthesiologists. Analysis of BI provides a non-invasive method to quantify fluid distribution in different body compartments. This study was designed to assess whether BI analysis reflects fluid depletion in neurosurgical patients with moderate blood loss. Six adult male patients scheduled for elective craniotomy under general anesthesia were studied. Exclusion criteria included patients with cardio-respiratory disease. BI analysis was performed at three stages, A, day before operation, B, during surgery and C, on the first postoperative day. Total body resistivity was measured by BI analysis with a four-terminal portable impedence analyzer. At each frequency, impedence was calculated as resistance (Rx)2 + reactance (Rc)2. The mean values of total body water (TBW) at stages A, B and C were 39.8 L (range: 33.1-46.7 L), 43.2 L (range: 33.1-66.2 L) and 36.8 L (range: 22.4-36.3 L) respectively with significant differences (P<0.05). The impedence at the three frequencies during stages A, B and C showed significant differences (P<0.05). In conclusion, we have found that in male neurosurgical patients multiple frequency BI measurements has reflected fluid balance perioperatively. Whether this observation remains true for other surgical procedures with massive blood loss, yet to be further investigated.

  15. Bioelectric signaling regulates size in zebrafish fins.

    Directory of Open Access Journals (Sweden)

    Simon Perathoner

    2014-01-01

    Full Text Available The scaling relationship between the size of an appendage or organ and that of the body as a whole is tightly regulated during animal development. If a structure grows at a different rate than the rest of the body, this process is termed allometric growth. The zebrafish another longfin (alf mutant shows allometric growth resulting in proportionally enlarged fins and barbels. We took advantage of this mutant to study the regulation of size in vertebrates. Here, we show that alf mutants carry gain-of-function mutations in kcnk5b, a gene encoding a two-pore domain potassium (K(+ channel. Electrophysiological analysis in Xenopus oocytes reveals that these mutations cause an increase in K(+ conductance of the channel and lead to hyperpolarization of the cell. Further, somatic transgenesis experiments indicate that kcnk5b acts locally within the mesenchyme of fins and barbels to specify appendage size. Finally, we show that the channel requires the ability to conduct K(+ ions to increase the size of these structures. Our results provide evidence for a role of bioelectric signaling through K(+ channels in the regulation of allometric scaling and coordination of growth in the zebrafish.

  16. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    MashhourMustafaBaniAmer

    2003-01-01

    This papenr deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events.The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers.The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resitors have a larger value.This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors.Moreover,the new designed bioelectric amplifier haws an output noise less than that for conventional amplifiers.The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  17. Effect of photostimulation on maize leaves’ bioelectrical response

    Directory of Open Access Journals (Sweden)

    M. P. Motsnyj

    2011-06-01

    Full Text Available Dynamics of the maize leaves’ biopotentials evoked by white, blue, green and red light stimuli with an intensity of 90 Lx illumination is analyzed. Qualitative similarity in dynamics of plant’s bioelectrical response to white and colored stimuli is determined. Hyperpolarization levels are quantitatively estimated for each experimental series. Dependence of the total hyperpolarization levels on the photostimulus wave length is detected. Mean amplitude of the hyperpolarization potentials lessens when the wave length decreases: from 57.7 mV under the red light to 27.7 mV under the blue one. Probable forms of bioelectrical response initiation in photostimulated plants are analyzed.

  18. Bioelectric impedance phase angle in breast carcinoma

    Directory of Open Access Journals (Sweden)

    Ruchi Tyagi

    2014-01-01

    Full Text Available Context: Worldwide breast cancer is the most frequently diagnosed life threatening cancer and the leading cause of death in women. Bioelectric impedance analysis (BIA affords an emerging opportunity to assess prognosis because of its ability to non invasively assess cell and plasma membrane structure and function by means of phase angle. Aims: To compare the phase angle between patients of breast cancer and their matched control with the help of BIA. Settings and Design: After taking clearance from ethical committee, a total of 34 female cases of histologically proven infiltrating ductal breast carcinoma were included from the surgery IPD, department of surgery. Equal numbers of the matched controls were recruited from the friends and relatives of cases. Materials and Methods: Bio Electrical Impedance Analyzer (BIA BODY STAT QUAD SCAN 4000 was used to measure resistance (R and reactance (Xc by recording a voltage drop in applied current. Phase angle is the ratio of reactance to resistance and is a measure of cell vitality. Statistical analysis used: Unpaired "t" test was applied. Results: In control group, the phase angle showed a mean of 5.479 whereas in test group, it showed a mean value of 4.726. The P value showed a significant difference (P < 0.0001. The smaller the phase angle values were higher was the tumor, nodes, metastases (TNM staging. The phase angles differed significantly from the healthy age matched control values. Conclusions: This study demonstrated that phase angle is a strong predictor of severity of breast cancer and differed significantly between the two groups.

  19. BIOELECTRICAL IMPEDANCE VECTOR ANALYSIS IDENTIFIES SARCOPENIA IN NURSING HOME RESIDENTS

    Science.gov (United States)

    Loss of muscle mass and water shifts between body compartments are contributing factors to frailty in the elderly. The body composition changes are especially pronounced in institutionalized elderly. We investigated the ability of single-frequency bioelectrical impedance analysis (BIA) to identify b...

  20. Carbon fiber enhanced bioelectricity generation in soil microbial fuel cells.

    Science.gov (United States)

    Li, Xiaojing; Wang, Xin; Zhao, Qian; Wan, Lili; Li, Yongtao; Zhou, Qixing

    2016-11-15

    The soil microbial fuel cell (MFC) is a promising biotechnology for the bioelectricity recovery as well as the remediation of organics contaminated soil. However, the electricity production and the remediation efficiency of soil MFC are seriously limited by the tremendous internal resistance of soil. Conductive carbon fiber was mixed with petroleum hydrocarbons contaminated soil and significantly enhanced the performance of soil MFC. The maximum current density, the maximum power density and the accumulated charge output of MFC mixed carbon fiber (MC) were 10, 22 and 16 times as high as those of closed circuit control due to the carbon fiber productively assisted the anode to collect the electron. The internal resistance of MC reduced by 58%, 83% of which owed to the charge transfer resistance, resulting in a high efficiency of electron transfer from soil to anode. The degradation rates of total petroleum hydrocarbons enhanced by 100% and 329% compared to closed and opened circuit controls without the carbon fiber respectively. The effective range of remediation and the bioelectricity recovery was extended from 6 to 20cm with the same area of air-cathode. The mixed carbon fiber apparently enhanced the bioelectricity generation and the remediation efficiency of soil MFC by means of promoting the electron transfer rate from soil to anode. The use of conductively functional materials (e.g. carbon fiber) is very meaningful for the remediation and bioelectricity recovery in the bioelectrochemical remediation.

  1. Validity of estimating limb muscle volume by bioelectrical impedance.

    Science.gov (United States)

    Miyatani, M; Kanehisa, H; Masuo, Y; Ito, M; Fukunaga, T

    2001-07-01

    The present study aimed to investigate the validity of estimating muscle volume by bioelectrical impedance analysis. Bioelectrical impedance and series cross-sectional images of the forearm, upper arm, lower leg, and thigh on the right side were determined in 22 healthy young adult men using a specially designed bioelectrical impedance acquisition system and magnetic resonance imaging (MRI) method, respectively. The impedance index (L(2)/Z) for every segment, calculated as the ratio of segment length squared to the impedance, was significantly correlated to the muscle volume measured by MRI, with r = 0.902-0.976 (P estimation was 38.4 cm(3) for the forearm, 40.9 cm(3) for the upper arm, 107.2 cm(3) for the lower leg, and 362.3 cm(3) for the thigh. Moreover, isometric torque developed in elbow flexion or extension and knee flexion or extension was significantly correlated to the L(2)/Z values of the upper arm and thigh, respectively, with correlation coefficients of 0.770-0.937 (P knee flexors or extensors. Thus the present study indicates that bioelectrical impedance analysis may be useful to predict the muscle volume and to investigate possible relations between muscle size and strength capability in a limited segment of the upper and lower limbs.

  2. Bioelectric Control of a 757 Class High Fidelity Aircraft Simulation

    Science.gov (United States)

    Jorgensen, Charles; Wheeler, Kevin; Stepniewski, Slawomir; Norvig, Peter (Technical Monitor)

    2000-01-01

    This paper presents results of a recent experiment in fine grain Electromyographic (EMG) signal recognition, We demonstrate bioelectric flight control of 757 class simulation aircraft landing at San Francisco International Airport. The physical instrumentality of a pilot control stick is not used. A pilot closes a fist in empty air and performs control movements which are captured by a dry electrode array on the arm, analyzed and routed through a flight director permitting full pilot outer loop control of the simulation. A Vision Dome immersive display is used to create a VR world for the aircraft body mechanics and flight changes to pilot movements. Inner loop surfaces and differential aircraft thrust is controlled using a hybrid neural network architecture that combines a damage adaptive controller (Jorgensen 1998, Totah 1998) with a propulsion only based control system (Bull & Kaneshige 1997). Thus the 757 aircraft is not only being flown bioelectrically at the pilot level but also demonstrates damage adaptive neural network control permitting adaptation to severe changes in the physical flight characteristics of the aircraft at the inner loop level. To compensate for accident scenarios, the aircraft uses remaining control surface authority and differential thrust from the engines. To the best of our knowledge this is the first time real time bioelectric fine-grained control, differential thrust based control, and neural network damage adaptive control have been integrated into a single flight demonstration. The paper describes the EMG pattern recognition system and the bioelectric pattern recognition methodology.

  3. NOVEL DESIGN OF A BIOELECTRIC AMPLIFIER WITH MINIMIZED MAGNITUDE AND PHASE ERRORS

    Institute of Scientific and Technical Information of China (English)

    Mashhour Bani Amer; Assistant Professor

    2001-01-01

    A new design of a bioelectric amplifier that has better parameters than conventional designs is presented. The design allows the construction of bioelectric amplifier with improved parameters in terms of common-mode rejection ratio and phase and magnitude errors. The voltage gain is easily adapted to a wide range of biomedical applications. The experimental and simulation results of the designed bioelectric amplifier are also included.

  4. Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Yuanwen; Carvalho-de-Souza, João L.; Wong, Raymond C. S.; Luo, Zhiqiang; Isheim, Dieter; Zuo, Xiaobing; Nicholls, Alan W.; Jung, Il Woong; Yue, Jiping; Liu, Di-Jia; Wang, Yucai; De Andrade, Vincent; Xiao, Xianghui; Navrazhnykh, Luizetta; Weiss, Dara E.; Wu, Xiaoyang; Seidman, David N.; Bezanilla, Francisco; Tian, Bozhi

    2016-06-27

    Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-scale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical vapour deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework and random submicrometre voids, and shows an average Young’s modulus that is 2–3 orders of magnitude smaller than that of single-crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.

  5. Experimental verification of depolarization effects in bioelectrical impedance measurement.

    Science.gov (United States)

    Chen, Xiaoyan; Lv, Xinqiang; Du, Meng

    2014-01-01

    The electrode polarization effects on bioelectrical impedance measurement at low-frequency cannot be ignored. In this paper, the bioelectrical data of mice livers are measured to specify the polarization effects on the bio-impedance measurement data. We firstly introduce the measurement system and methodology. Using the depolarization method, the corrected results are obtained. Besides, the specific effects of electrode polarization on bio-impedance measurement results are investigated using comparative analysis of the previous and posterior correction results from dielectric spectroscopy, Cole-Cole plot, conductivity and spectroscopy of dissipation tangent. Experimental results show that electrode polarization has a significant influence on the characteristic parameters of mouse liver tissues. To be specific, we see a low-frequency limit resistance R0 increase by 19.29%, a reactance peak XP increase by 8.50%, a low-frequency limit conductivity Kl decrease by 17.65% and a dissipation peak tangent decrease by 160%.

  6. NEUROFEEDBACK INFLUENCE ON CEREBRUM BIOELECTRICAL ACTIVITY IN GYMNASTS-WOMEN

    Directory of Open Access Journals (Sweden)

    T. Yu. Strizhkova

    2013-01-01

    Full Text Available The analysis of electroencephalogram (EEG of highly skilled gymnasts-women (main group – 49, control group – 39 showed the availability of cerebrum bioelectrical activity features of sportswomen connected with left hemisphere dominance, predominance of theta-rhythm power and lower reaction to eyes closing, also character of neurodynamic changes generated by neurofeedback course depended on ovarian-menstrual cycle phases.

  7. [Endocrine obesity: bioelectric profiles (biotypes) detected in the body composition].

    Science.gov (United States)

    Miggiano, G A D; Petitti, T

    2004-09-01

    136 patients were selected (16 men and 120 women with non-specific menstrual disturbances) with a BMI (Body Mass Index) between 25 and 45 kg/m2, which were diagnosed with "disendocrinia" (GH deficit, hyperadrenocorticism, hypothyroidsm, hyperandrogenism, menstrual cycle disorders). The proposed approach, based on the visualization of the value distribution of the electric measures in different graphics, is able to immediately explain the bioelectric state of the individual's lean-mass. Subjects with hypothyroidism present, along with their overweight, less bio-conducting mass, with an altered fluid intra/extra-cellular distribution. Patients with hyperadrenocorticism show instead an hyperhydratation of the body mass, especially in the extracellular level. Patients with menstrual disorders (amenorrea, polycystic ovary syndrome, anovulatory cycle etc...) present a lean mass reduction (elevated Rs) and an increase of the intra-cellular compartment (elevated-Xc). Patients with hyper-androgenism (and hirsutism) show a characteristic bioelectric "pattern", with low Rs levels and high Xc levels. Subjects with GH deficit (men and women), has a trend of documenting bioelectric measures with lower lean mass and higher fat-mass. Different electric biotypes seem to characterize the body composition in the several endocrine disorders.

  8. Bioelectrical signal processing in cardiac and neurological applications and electromyography: physiology, engineering, and noninvasive applications

    Directory of Open Access Journals (Sweden)

    Valentinuzzi Max E

    2007-07-01

    Full Text Available Abstract The present article reviews two recent books dealing with rather closely related subjects; in fact, they tend to complement and supplement reciprocally. Obviously, the electromyogram is a bioelectrical signal that often is mathematically manipulated in different ways to better extract its information. Moreover, its correlation with other bioelectric variables may become necessary.

  9. Bioelectricity production from various wastewaters through microbial fuel cell technology

    Directory of Open Access Journals (Sweden)

    Abhilasha S Mathuriya

    2009-12-01

    Full Text Available Microbial fuel cell technology is a new type of renewable and sustainable technology for electricity generation since it recovers energy from renewable materials that can be difficult to dispose of, such as organic wastes and wastewaters. In the present contribution we demonstrated electricity production by beer brewery wastewater, sugar industry wastewater, dairy wastewater, municipal wastewater and paper industry wastewater. Up to 14.92 mA current and 90.23% COD removal was achieved in 10 days of operation. Keywords: Bioelectricity, COD, Microbial Fuel Cells, Wastewater Received: 12 November 2009 / Received in revised form: 30 November 2009, Accepted: 30 November 2009, Published online: 10 March 2010

  10. Compost in plant microbial fuel cell for bioelectricity generation.

    Science.gov (United States)

    Moqsud, M A; Yoshitake, J; Bushra, Q S; Hyodo, M; Omine, K; Strik, David

    2015-02-01

    Recycling of organic waste is an important topic in developing countries as well as developed countries. Compost from organic waste has been used for soil conditioner. In this study, an experiment has been carried out to produce green energy (bioelectricity) by using paddy plant microbial fuel cells (PMFCs) in soil mixed with compost. A total of six buckets filled with the same soil were used with carbon fiber as the electrodes for the test. Rice plants were planted in five of the buckets, with the sixth bucket containing only soil and an external resistance of 100 ohm was used for all cases. It was observed that the cells with rice plants and compost showed higher values of voltage and power density with time. The highest value of voltage showed around 700 mV when a rice plant with 1% compost mixed soil was used, however it was more than 95% less in the case of no rice plant and without compost. Comparing cases with and without compost but with the same number of rice plants, cases with compost depicted higher voltage to as much as 2 times. The power density was also 3 times higher when the compost was used in the paddy PMFCs which indicated the influence of compost on bio-electricity generation.

  11. Optically Controlled Oscillators in an Engineered Bioelectric Tissue

    Science.gov (United States)

    McNamara, Harold M.; Zhang, Hongkang; Werley, Christopher A.; Cohen, Adam E.

    2016-07-01

    Complex electrical dynamics in excitable tissues occur throughout biology, but the roles of individual ion channels can be difficult to determine due to the complex nonlinear interactions in native tissue. Here, we ask whether we can engineer a tissue capable of basic information storage and processing, where all functional components are known and well understood. We develop a cell line with four transgenic components: two to enable collective propagation of electrical waves and two to enable optical perturbation and optical readout of membrane potential. We pattern the cell growth to define simple cellular ring oscillators that run stably for >2 h (˜104 cycles ) and that can store data encoded in the direction of electrical circulation. Using patterned optogenetic stimulation, we probe the biophysical attributes of this synthetic excitable tissue in detail, including dispersion relations, curvature-dependent wave front propagation, electrotonic coupling, and boundary effects. We then apply the biophysical characterization to develop an optically reconfigurable bioelectric oscillator. These results demonstrate the feasibility of engineering bioelectric tissues capable of complex information processing with optical input and output.

  12. Microbiology and optimization of hydrogen fermentation and bioelectricity production

    Energy Technology Data Exchange (ETDEWEB)

    Makinen, A.

    2013-11-01

    This work investigated dark fermentative hydrogen (H{sub 2}) and bioelectricity production from carbohydrates. Meso- and thermophilic fermentative and mesophilic exoelectrogenic bacteria were enriched from different natural sources. The H{sub 2} production from different hexoses and pentoses, them main constituents of lignocellulose, was studied in batch assays. H{sub 2} production from xylose was examined in continuous stirred tank reactor (CSTR). Operational parameters for H{sub 2} production were optimized. Bioelectricity production was studied in microbial fuel cells and process parameters were optimized. Dynamics of microbial communities in H{sub 2} and bioelectricity production processes were determined. A novel thermophilic dark fermentative H{sub 2} producing bacterium, Thermovorax subterraneus, was enriched and isolated from geothermal underground mine. T. subterraneus had the optimum growth temperature of 72 deg C and the maximum H{sub 2} yield of 1.4 mol/mol glucose in batch assay. The main soluble fermentative end products of T. subterraneus were acetate and ethanol. Thermophilic dark fermentative mixed culture enriched from hot spring (Hisarlan, Turkey) had the maximum H{sub 2} yield of 1.7 mol/mol glucose. The optimal environmental parameters to maximize H{sub 2} yield were temperature 52 deg C, initial pH 6.5, 40 mg/L Fe{sup 2+}, 4.5 g/L yeast extract and glucose concentration of 4 g/L. Increasing the glucose concentration to 18 g/L increased the maximum H{sub 2} production rate to 56.2 mmol H{sub 2}/h/L. Environmental parameters had a significant effect on metabolic pathways of fermentation. Another hot spring (Hisarkoy, Turkey) enrichment culture was able to ferment different sugars to H{sub 2} favoring pentoses over hexoses. The best H{sub 2} yields in batch assays were obtained from pentoses: xylose, arabinose and ribose yielded 21, 15 and 8 % of the theoretical yield, respectively; whilst on glucose the yield was only 2 % of the theoretical

  13. A parametric framework for modelling of bioelectrical signals

    CERN Document Server

    Mughal, Yar Muhammad

    2016-01-01

    This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move...

  14. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men

    Science.gov (United States)

    Rodríguez-Rodríguez, Fernando; Cristi-Montero, Carlos; González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Ramírez-Vélez, Robinson

    2016-01-01

    Muscle strength can define the general muscular fitness (MF) measurable through hand-grip strength (HG), which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA) was conducted to determine the resistance (R), reactance (Xc) and phase angle (PhA). We classified the subjects into three groups (for tertiles), obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA’s parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting. PMID:27384579

  15. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men

    Directory of Open Access Journals (Sweden)

    Fernando Rodríguez-Rodríguez

    2016-07-01

    Full Text Available Muscle strength can define the general muscular fitness (MF measurable through hand-grip strength (HG, which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA was conducted to determine the resistance (R, reactance (Xc and phase angle (PhA. We classified the subjects into three groups (for tertiles, obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA’s parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting.

  16. Response Characteristics of Plant Bioelectric Potential to Light Intensity Indoor and Outdoor

    Science.gov (United States)

    Shimbo, Tatsuya; Fujii, Masaki; Sawada, Ayako; Oyabu, Takashi; Kimura, Haruhiko

    Plant is affected by environmental factors. For example, these are temperature, humidity and light intensity. The light intensity affected strongly to the plant. The plant produces glucose and oxygen with photosynthesis. Moreover, light intensity is important to purify the contaminants in the atmosphere. In this study, it was examined whether the plant is affected by temperature, wind grade and soil moisture using bioelectric potential characteristics of the plant. Especially plant bioelectric potential to light intensity change was measured. The measurement was carried out in indoor and outdoor. As for the result, the differences of plant bioelectric potential characteristics in the indoor and outdoor were recognized. At that analysis, the integrated value of plant bioelectric potential for 1 minute (vm1) was adopted. Moreover, a high correlation was indicated between the vm1 and light intensity. The correlation coefficient was R2=0.94. It becomes obvious that the plant is affected strongly by light intensity and the plant can understand the environmental factors like light intensity. The characteristics are found by measuring bioelectric potential of the plant. The environmental sensing can be possible by the use of the plant bioelectric potential.

  17. Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration.

    Science.gov (United States)

    Levin, Michael

    2014-06-01

    Pattern formation, as occurs during embryogenesis or regeneration, is the crucial link between genotype and the functions upon which selection operates. Even cancer and aging can be seen as challenges to the continuous physiological processes that orchestrate individual cell activities toward the anatomical needs of an organism. Thus, the origin and maintenance of complex biological shape is a fundamental question for cell, developmental, and evolutionary biology, as well as for biomedicine. It has long been recognized that slow bioelectrical gradients can control cell behaviors and morphogenesis. Here, I review recent molecular data that implicate endogenous spatio-temporal patterns of resting potentials among non-excitable cells as instructive cues in embryogenesis, regeneration, and cancer. Functional data have implicated gradients of resting potential in processes such as limb regeneration, eye induction, craniofacial patterning, and head-tail polarity, as well as in metastatic transformation and tumorigenesis. The genome is tightly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream genes whose transcription is regulated by voltage, and transduction machinery that converts changes in bioelectric state to second-messenger cascades. However, the data clearly indicate that bioelectric signaling is an autonomous layer of control not reducible to a biochemical or genetic account of cell state. The real-time dynamics of bioelectric communication among cells are not fully captured by transcriptomic or proteomic analyses, and the necessary-and-sufficient triggers for specific changes in growth and form can be physiological states, while the underlying gene loci are free to diverge. The next steps in this exciting new field include the development of novel conceptual tools for understanding the anatomical semantics encoded in non-neural bioelectrical networks, and of improved biophysical tools for reading and writing

  18. Biogenic metallic nanoparticles as catalyst for bioelectricity production: A novel approach in microbial fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Saravanakumar, Kandasamy, E-mail: saravana732@gmail.com [School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai (China); State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai (China); Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai (China); MubarakAli, Davoodbasha [Microbial Genetic Engineering Laboratory, Division of Bioengineering, College of Life Science and Bioengineering, Incheon National University, Songdo 406772, Incheon (Korea, Republic of); Department of Microbiology, School of Lifesciences, Bharathidasan University, Tiruchirappalli 620024 (India); Kathiresan, Kandasamy [Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu (India); Thajuddin, Nooruddin [Department of Microbiology, School of Lifesciences, Bharathidasan University, Tiruchirappalli 620024 (India); Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia); Alharbi, Naiyf S. [Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia); Chen, Jie, E-mail: jiechen59@sjtu.edu.cn [School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai (China); State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai (China); Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai (China)

    2016-01-15

    Highlights: • Trichoderma sp., showed an abilities to synthesis of AgNPs and AuNPs with an excellent stability. • AuNPs significantly enhanced the bioelectricity production by MFC of anaerobic fermentation as catalyst. • Maximum bioelectricity production was optimized and obtained the voltage of 432.80 mA using RSM. - Abstract: The present work aimed to use the biogenic metallic nanoparticles as catalyst for bioelectricity production in microbial fuel cell (MFC) approach under anaerobic condition. Silver and gold nanoparticles (AuNPs) were synthesized using Trichoderma sp. Particle size and cystallinity were measured by X-ray diffraction revealed the crystalline structure with average size of 36.17 nm. Electron microscopic studies showed spherical shaped silver nanoparticles (AgNPs) and cubical shaped AuNPs with size ranges from 50 to 150 nm. The concentration of biogenic metallic nanoparticles as catalyst for enhanced bioelectricity generations and estimated by response surface methodology (RSM) and found at the greatest of 342.80 mA under optimized conditions are time interval, temperature, nanoparticles used as 63 h, 28 ± 2.0 °C, 22.54 mg l{sup −1} (AgNPs) and 25.62 mg l{sup −1} (AuNPs) in a batch reactor. AuNPs acted as an excellent catalyst to enhance the bioelectricity production. This novel technique could be used for eco-friendly, economically feasible and facile electricity production.

  19. Advantages of Nanosensors in the Development of Interfaces for Bioelectric Prostheses

    Directory of Open Access Journals (Sweden)

    Avdeeva Diana

    2016-01-01

    Full Text Available The present research aims to explore the bioelectric activity of muscles using a high-resolution electromyograph and to analyze the prospects of the electromyograph to develop bioelectric patterns for the prosthesis control method based on the data recognition system. The activity of the healthy forearm muscles was investigated during the cyclic activity of fingers in different modes. In addition, the impact of filters on the quality and informativity of myoelectric signals, as well as on the development of bioelectric activity patterns was analyzed. The virtually developed bandpass filters were utilized as experimental filters. The filter impact analysis included the comparison of the signal recorded in the frequency band from 0 to 10000 Hz with the signal filtered in the frequency band from 20 to 500 Hz. The research revealed the advantages of a high-resolution electromyogram for the pattern recognition-based myocontrol.

  20. Modified Blumlein pulse-forming networks for bioelectrical applications.

    Science.gov (United States)

    Romeo, Stefania; Sarti, Maurizio; Scarfì, Maria Rosaria; Zeni, Luigi

    2010-07-01

    Intense nanosecond pulsed electric fields (nsPEFs) have been shown to induce, on intracellular structures, interesting effects dependent on electrical exposure conditions (pulse length and amplitude, repetition frequency and number of pulses), which are known in the literature as "bioelectrical effects" (Schoenbach et al., IEEE Trans Plasma Sci 30:293-300, 2002). In particular, pulses with a shorter width than the plasma membrane charging time constant (about 100 ns for mammalian cells) can penetrate the cell and trigger effects such as permeabilization of intracellular membranes, release of Ca(2+) and apoptosis induction. Moreover, the observed effects have led to exploration of medical applications, like the treatment of melanoma tumors (Nuccitelli et al., Biochem Biophys Res Commun 343:351-360, 2006). Pulsed electric fields allowing such effects usually range from several tens to a few hundred nanoseconds in duration and from a few to several tens of megavolts per meter in amplitude (Schoenbach et al., IEEE Trans Diel Elec Insul 14:1088-1109, 2007); however, the biological effects of subnanosecond pulses have been also investigated (Schoenbach et al., IEEE Trans Plasma Sci 36:414-422, 2008). The use of such a large variety of pulse parameters suggests that highly flexible pulse-generating systems, able to deliver wide ranges of pulse durations and amplitudes, are strongly required in order to explore effects and applications related to different exposure conditions. The Blumlein pulse-forming network is an often-employed circuit topology for the generation of high-voltage electric pulses with fixed pulse duration. An innovative modification to the Blumlein circuit has been recently devised which allows generation of pulses with variable amplitude, duration and polarity. Two different modified Blumlein pulse-generating systems are presented in this article, the first based on a coaxial cable configuration, matching microscopic slides as a pulse-delivery system

  1. A comparison of skinfolds and leg-to-leg bioelectrical impedance for the assessment of body composition in children

    Science.gov (United States)

    Goss, Fredric; Robertson, Robert; Williams, Allison; Sward, Kathy; Abt, Kristi; Ladewig, Melissa; Timmer, Jeffrey; Dixon, Curt

    2003-01-01

    Background This field-based investigation examined the congruence between skinfolds and bioelectrical impedance in assessing body composition in children. Methods Subjects were 162 female and 160 male children 10–15 years of age. Skinfold measures obtained at the triceps and medial calf and a leg-to-leg bioelectrical impedance system were used to determine percent fat using child-specific equations. Pearson product moment correlations were performed on the percent fat values obtained using skinfolds and bioelectric impedance for the entire data set. Separate correlations were also conducted on gender and age/gender subsets. Dependent t tests were used to compare the two techniques. Results Percent fat did not differ between skinfolds and bioelectrical impedance for the total subject pool. Bioelectrical impedance overestimated percent fat in girls by 2.6% and underestimated percent fat in boys by 1.7% (p < 0.01). Correlations between skinfolds and bioelectrical impedance ranged from r = 0.51 to r = 0.90. Conclusions Leg-to-leg bioelectrical impedance may be a viable alternative field assessment technique that is comparable to skinfolds. The small differences in percent fat between the two techniques may have limited practical significance in school-based health-fitness settings. PMID:14498990

  2. The Evaluation of Bioelectrical Activity of Pelvic Floor Muscles Depending on Probe Location: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Tomasz Halski

    2013-01-01

    Full Text Available Objectives. The main objective was to determine how the depth of probe placement affects functional and resting bioelectrical activity of the PFM and whether the recorded signal might be dependent on the direction in which the probe is rotated. Participants. The study comprised of healthy, nulliparous women between the ages of 21 and 25. Outcome Measures. Bioelectric activity of the PFM was recorded from four locations of the vagina by surface EMG and vaginal probe. Results. There were no statistically significant differences between the results during functional sEMG activity. During resting sEMG activity, the highest bioelectrical activity of the PFM was observed in the L1 and the lowest in the L4 and a statistically significant difference between the highest and the lowest results of resting sEMG activity was observed (P=0.0043. Conclusion. Different electrodes placement during functional contraction of PFM does not affect the obtained results in sEMG evaluation. In order to diagnose the highest resting activity of PFM the recording plates should be placed toward the anterior vaginal wall and distally from the introitus. However, all of the PFM have similar bioelectrical activity and it seems that these muscles could be treated as a single muscle.

  3. Impact of hemodialysis on dual X-ray absorptiometry, bioelectrical impedance measurements, and anthropometry

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Hansen, T B; Høgsberg, I M;

    1996-01-01

    ), bioelectrical impedance analysis (BIA), and simple anthropometry in 19 patients (9 women and 10 men, mean age 46 y) before and after hemodialysis, removing 0.9-4.3 L (x: 2.8L) of ultrafiltrate. The reduction in fat-free mass (FFM) measured by DXA was highly correlated with the ultrafiltrate, as determined...

  4. [Principles of design of neural-network analog-to-digital converters of bioelectric signals].

    Science.gov (United States)

    Loktiukhin, V N; Chelebaev, S V

    2007-01-01

    A design principle and a procedure for synthesis of neural-network analog-to-digital converters of bioelectric signals are suggested. An example of implementation of an FPGA-based neural-network converter for classification of bioparameters is presented.

  5. Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering.

    Science.gov (United States)

    Levin, Michael; Stevenson, Claire G

    2012-01-01

    Achieving control over cell behavior and pattern formation requires molecular-level understanding of regulatory mechanisms. Alongside transcriptional networks and biochemical gradients, there functions an important system of cellular communication and control: transmembrane voltage gradients (V(mem)). Bioelectrical signals encoded in spatiotemporal changes of V(mem) control cell proliferation, migration, and differentiation. Moreover, endogenous bioelectrical gradients serve as instructive cues mediating anatomical polarity and other organ-level aspects of morphogenesis. In the past decade, significant advances in molecular physiology have enabled the development of new genetic and biophysical tools for the investigation and functional manipulation of bioelectric cues. Recent data implicate V(mem) as a crucial epigenetic regulator of patterning events in embryogenesis, regeneration, and cancer. We review new conceptual and methodological developments in this fascinating field. Bioelectricity offers a novel way of quantitatively understanding regulation of growth and form in vivo, and it reveals tractable, powerful control points that will enable truly transformative applications in bioengineering, regenerative medicine, and synthetic biology.

  6. Bioelectricity from kitchen and bamboo waste in a microbial fuel cell.

    Science.gov (United States)

    Moqsud, M Azizul; Omine, Kiyoshi; Yasufuku, Noriyuki; Bushra, Quazi S; Hyodo, Masayuki; Nakata, Yukio

    2014-02-01

    This study evaluated bioelectricity generation by using kitchen garbage (KG) and bamboo waste (BW) as a solid waste management option by a microbial fuel cell (MFC) method. The nutrient content [nitrogen, phosphorus and potassium (NPK)] of the by-products of bioelectricity were also analyzed and assessed for their potential use as a soil amendment. A one-chamber MFC was used for bioelectricity generation in laboratory experiments using both KG and BW. A data-logger recorded voltage every 20 mins at a constant room temperature of 25°C over 45 days. The trend of voltage generation was different for the two organic wastes. In the case of KG, the voltage at the initial stage (0-5 days) increased rapidly and then gradually to a peak of 620 mV. In contrast, the voltage increased gradually to a peak of 540 mV in the case of BW. The by-products of bioelectricity can be used as soil conditioner as its NPK content was in the range of soil conditioner mentioned in other literature. Thus, the MFC has emerged as an efficient and eco-friendly solution for organic waste management, especially in developing and technologically less sophisticated countries, and can provide green and safe electricity from organic waste.

  7. Low-noise two-wired buffer electrodes for bioelectric amplifiers.

    Science.gov (United States)

    Degen, Thomas; Torrent, Simon; Jäckel, Heinz

    2007-07-01

    Active buffer electrodes are known to improve the immunity of bioelectric recordings against power line interferences. A survey of published work reveals that buffer electrodes are almost exclusively designed using operational amplifiers (opamps). In this paper, we discuss the advantage of utilizing a single transistor instead. This allows for a simple electrode, which is small and requires only two wires. In addition, a single transistor adds considerably less noise when compared to an opamp with the same power consumption. We then discuss output resistance and gain as well as their respective effect on the common mode rejection ratio (CMRR). Finally, we demonstrate the use of two-wired buffer electrodes for a bioelectric amplifier.

  8. ELF-magnetic field induced effects on the bioelectric activity of single neurone cells

    Science.gov (United States)

    Azanza, Maria J.; del Moral, A.

    1998-01-01

    The membrane bioelectric activity recorded from single neurones is dramatically modified under applied extremely low frequency magnetic fields (ELF-MF) of 50 Hz and 1-15 mT peak intensity. In ≌27% of the neurones studied a firing rhythm is generated for ≌7 mT, which resembles synchronous oscillations activity. The possibility that ELF-MF could generate neuronal networks synchrony firing does exist as an explanatory physical model shows.

  9. Bioinspired Nanosucker Array for Enhancing Bioelectricity Generation in Microbial Fuel Cells.

    Science.gov (United States)

    Wang, Wei; You, Shijie; Gong, Xiaobo; Qi, Dianpeng; Chandran, Bevita K; Bi, Lanpo; Cui, Fuyi; Chen, Xiaodong

    2016-01-13

    A bioinspired active anode with a suction effect is demonstrated for microbial fuel cells by constructing polypyrrole (PPy) nanotubular arrays on carbon textiles. The oxygen in the inner space of the nanosucker can be depleted by micro-organisms with the capability of facul-tative respiration, forming a vacuum, which then activates the electrode to draw the microorganism by suction and thus improve the bioelectricity generation.

  10. Brain bioelectrical activity changes in patients with poststroke depression and apathy

    Directory of Open Access Journals (Sweden)

    I. V. Kichuk

    2015-01-01

    Full Text Available Objective: to study the specific features of brain bioelectrical activity in patents with poststroke apathy and depressive disorders.Patients and methods. The investigation enrolled 175 patients (84 men and 91 women with new-onset cerebral stroke at different sites. A total of 107 (61% patients of them were observed to have depressive disorders (n=41 (38% and apathy (n=66 (62% within a year after disease onset. A control group included 68 (39% patients without poststroke affective disorders. The mean age of the study group patients was 66±10 years and that of the control patients was 68±11 years. The severity and magnitude of neurological deficit were evaluated using the U.S. National Institutes of Health Stroke Scale (NIHSS. The patients underwent electroencephalography (EEG, brain computed tomography and magnetic resonance imaging. The investigators used diagnostic and statistical manual of mental disorders (DSM-IV criteria to diagnose depression and the Hamilton depression rating scale (HAM-D and the mini-mental status examination (MMSE to evaluate the mental status. The basic rhythmic power indices in the affected and unaffected hemispheres were calculated, as well as anteroposterior alpha rhythm distribution coefficient and interhemispheric asymmetry coefficient. Results and discussion. The computer EEG analysis was shown to identify the hallmark characteristics of brain bioelectric activity in patients with different types of affective disorders in the acute, early and late recovery periods of stroke. The patients with affective disorders were found to have brain bioelectrical activity changes predominantly in the rapid frequency sub-band on EEG, suggesting midbrain structural dysfunction. In the patients with poststroke depression, depressive disorder scale scores were related to the power of bioelectric activity in the slow and alpha frequency bands manly in the acute stroke period whereas those were correlated with the EEG

  11. Smart Multi-Frequency Bioelectrical Impedance Spectrometer for BIA and BIVA Applications.

    Science.gov (United States)

    Harder, Rene; Diedrich, Andre; Whitfield, Jonathan S; Buchowski, Macie S; Pietsch, John B; Baudenbacher, Franz J

    2016-08-01

    Bioelectrical impedance analysis (BIA) is a noninvasive and commonly used method for the assessment of body composition including body water. We designed a small, portable and wireless multi-frequency impedance spectrometer based on the 12 bit impedance network analyzer AD5933 and a precision wide-band constant current source for tetrapolar whole body impedance measurements. The impedance spectrometer communicates via Bluetooth with mobile devices (smart phone or tablet computer) that provide user interface for patient management and data visualization. The export of patient measurement results into a clinical research database facilitates the aggregation of bioelectrical impedance analysis and biolectrical impedance vector analysis (BIVA) data across multiple subjects and/or studies. The performance of the spectrometer was evaluated using a passive tissue equivalent circuit model as well as a comparison of body composition changes assessed with bioelectrical impedance and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Our results show an absolute error of 1% for resistance and 5% for reactance measurements in the frequency range of 3 kHz to 150 kHz. A linear regression of BIA and DXA fat mass estimations showed a strong correlation (r(2)=0.985) between measures with a maximum absolute error of 6.5%. The simplicity of BIA measurements, a cost effective design and the simple visual representation of impedance data enables patients to compare and determine body composition during the time course of a specific treatment plan in a clinical or home environment.

  12. Use of bioelectrical impedance analysis to determine body composition changes in HIV-associated wasting.

    Science.gov (United States)

    Klauke, Stephan; Fischer, Harald; Rieger, Armin; Frühauf, Lukas; Staszewski, Schlomo; Althoff, Peter-Henning; Helm, Eilke Brigitte

    2005-04-01

    AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+ count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P = 0.146), and significant increases in mean body cell mass (+8.0%, P = 0.0211), lean body mass (+4.8%, P = 0.0373) and water (+5.5%, P r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.

  13. Bioelectrical impedance analysis for the prediction of hot carcass weight in buffalo calf

    Directory of Open Access Journals (Sweden)

    Leopoldo Iannuzzi

    2010-01-01

    Full Text Available Twenty young buffalo male calves were fed ad libitum with a total mix ration and with vitamin-mineral integration for 14 months. Seven days before slaughter, the animals were weighed and bioelectrical impedance measurements were collected in live animals. Physical and chemical characteristics were assessed on the Longissimus dorsi muscle after slaughter. Correlations and regression equations were calculated to determine the possible use of bioelectrical impedance for evaluating hot carcass weight. Bioelectrical impedance analysis at different frequencies, simple correlation and analysis of regression were examined for all the data collected, supporting the possibility of hot carcass weight prediction with equation at multifrequency. The results show that, probably due to the variability in animal live weight, the distribution of the colour parameters was not normally distributed. Moreover, using different frequencies of resistance and reactance, hot carcass weight in buffalo may be predicted with the following equation: Y=98.47–8.84(Rs100KHz+4.41(Rs1000 KHz-116.27(Xc5 KHz+51.04(Xc50 KHz+20.30(Xc100 KHz-33.92(Xc500 KHz+9.01(Xc1000 KHz±ε (Adjusted R Square value of .907 and SE of 5.728 However, further studies are required to improve the technique also in buffalo, after standardization of the method.

  14. [Specifics of perception of acoustic image of intrinsic bioelectric brain activity].

    Science.gov (United States)

    Konstantinov, K V; Leonova, M K; Miroshnikov, D B; Klimenko, V M

    2014-06-01

    We studied the particularities of perception of the acoustic image of intrinsic EEG. We found that the assessment of perception of sounds, the presentation of which was synchronized and was agreed with current bioelectric brain activity, is higher that assessment of perception of acoustic EEG image presented in recorded form. Presentation of recorded acoustic image of EEG is accompanied by increased activity of beta-band in the frontal areas, while real-time presentation of acoustic EEG image is accompanied by the increase of slow wave activity: theta- and delta-bands of occipital areas of the brain. Increase activity in theta- and delta-bands of occipital areas in sessions of hearing the acoustic image of EEG in real time depend on the baseline frequency structure of EEG and correlates with expression of alpha-, beta- and theta-bands of bioelectric brain activity in both frontal and occipital areas. We suppose that presentation of sounds synchronized and agreed with the current bioelectric activity, activated the regulatory brain structures.

  15. Models of intracellular mechanisms of plant bioelectrical potentials caused by combined stimulation

    Directory of Open Access Journals (Sweden)

    D. V. Chernetchenko

    2014-10-01

    Full Text Available This paper deals with bioelectrical potentials of the plants recorded during different types of stimuli and combined stimulus as well. All registrations were observed on the leaves of the corn. We used different stimuli, such as cold, heat, photo- and electrical stimulation, and certain combination of this stimuli. Hardware and software system for automated recording of bioelectrical potentials has been successfully used in this work. We proposed the universal pattern of bioelectrical potentials’ recording which allowed to detect the response of the biological object to different stimuli and various combinations of these stimuli. This pattern can be used for the deeper understanding of biological mechanisms of electrical potentials’ generation in cells and discovering of processes of accommodation of whole organisms to these stimuli. Integrated system of recording and biometrical processing was used for analysis of corn leaves electrical responses to the thermal stimuli. The dynamics of these potentials was studied, with the quantitative analysis of the potential level stabilization.We calculated the ratio of amplitude of response potentials to the first response amplitude. Mathematical models of the plant cell were used for studying of intracellular mechanisms of biopotentials gereration. As a result of modeling, we revealed that electrical response of the cells was based on selectiveconductivity of cell membrane for Н+ and Ca2+ ions. Therefore, we showed the biophysical relation of plant potentials to underlying intracellular biophysical mechanisms during thermal and combined stimulation.

  16. Enhanced microbial reduction of vanadium (V) in groundwater with bioelectricity from microbial fuel cells

    Science.gov (United States)

    Hao, Liting; Zhang, Baogang; Tian, Caixing; Liu, Ye; Shi, Chunhong; Cheng, Ming; Feng, Chuanping

    2015-08-01

    Bioelectricity generated from the microbial fuel cell (MFC) is applied to the bioelectrical reactor (BER) directly to enhance microbial reduction of vanadium (V) (V(V)) in groundwater. With the maximum power density of 543.4 mW m-2 from the MFC, V(V) removal is accelerated with efficiency of 93.6% during 12 h operation. Higher applied voltage can facilitate this process. V(V) removals decrease with the increase of initial V(V) concentration, while extra addition of chemical oxygen demand (COD) has little effect on performance improvement. Microbial V(V) reduction is enhanced and then suppressed with the increase of conductivity. High-throughput 16S rRNA gene pyrosequencing analysis implies the accumulated Enterobacter and Lactococcus reduce V(V) with products from fermentative microorganisms such as Macellibacteroides. The presentation of electrochemically active bacteria as Enterobacter promotes electron transfers. This study indicates that application of bioelectricity from MFCs is a promising strategy to improve the efficiency of in-situ bioremediation of V(V) polluted groundwater.

  17. Bioelectricity potential in Mato Grosso do Sul, Brazil; O potencial de bioeletricidade no Mato Grosso do Sul

    Energy Technology Data Exchange (ETDEWEB)

    Turdera, Eduardo Mirko Valenzuela [Universidade Federal da Grande Dourados (UFGD), Dourados, MS (Brazil). Faculdade de Ciencias Exatas e Tecnologicas], E-mail: eduardoturdera@ufgd.edu.br

    2009-07-01

    This paper presents the importance of bioelectricity power from renewable source in the power output of Mato Grosso do Sul (MS). The power energy capacity of MS could grow the next years due arrived of more of the thirty mills on medium term. This scenario will be very favorable because MS State will have conditions to meet power domestic market demand and to have significant surplus of electricity to export. Sugar cane crops are expanding and they could propitiate combined heat power (CHP or cogeneration) technology growth, we make an analysis about the share of the bioelectricity availability in MS power capacity installed. Bioelectricity could be good to MS as well as energy and economic aspects. (author)

  18. Body fat measurement by bioelectrical impedance and air displacement plethysmography: a cross-validation study to design bioelectrical impedance equations in Mexican adults

    Directory of Open Access Journals (Sweden)

    Valencia Mauro E

    2007-08-01

    Full Text Available Abstract Background The study of body composition in specific populations by techniques such as bio-impedance analysis (BIA requires validation based on standard reference methods. The aim of this study was to develop and cross-validate a predictive equation for bioelectrical impedance using air displacement plethysmography (ADP as standard method to measure body composition in Mexican adult men and women. Methods This study included 155 male and female subjects from northern Mexico, 20–50 years of age, from low, middle, and upper income levels. Body composition was measured by ADP. Body weight (BW, kg and height (Ht, cm were obtained by standard anthropometric techniques. Resistance, R (ohms and reactance, Xc (ohms were also measured. A random-split method was used to obtain two samples: one was used to derive the equation by the "all possible regressions" procedure and was cross-validated in the other sample to test predicted versus measured values of fat-free mass (FFM. Results and Discussion The final model was: FFM (kg = 0.7374 * (Ht2 /R + 0.1763 * (BW - 0.1773 * (Age + 0.1198 * (Xc - 2.4658. R2 was 0.97; the square root of the mean square error (SRMSE was 1.99 kg, and the pure error (PE was 2.96. There was no difference between FFM predicted by the new equation (48.57 ± 10.9 kg and that measured by ADP (48.43 ± 11.3 kg. The new equation did not differ from the line of identity, had a high R2 and a low SRMSE, and showed no significant bias (0.87 ± 2.84 kg. Conclusion The new bioelectrical impedance equation based on the two-compartment model (2C was accurate, precise, and free of bias. This equation can be used to assess body composition and nutritional status in populations similar in anthropometric and physical characteristics to this sample.

  19. Biohydrogen, biomethane and bioelectricity as crucial components of biorefinery of organic wastes: a review.

    Science.gov (United States)

    Poggi-Varaldo, Héctor M; Munoz-Paez, Karla M; Escamilla-Alvarado, Carlos; Robledo-Narváez, Paula N; Ponce-Noyola, M Teresa; Calva-Calva, Graciano; Ríos-Leal, Elvira; Galíndez-Mayer, Juvencio; Estrada-Vázquez, Carlos; Ortega-Clemente, Alfredo; Rinderknecht-Seijas, Noemí F

    2014-05-01

    Biohydrogen is a sustainable form of energy as it can be produced from organic waste through fermentation processes involving dark fermentation and photofermentation. Very often biohydrogen is included as a part of biorefinery approaches, which reclaim organic wastes that are abundant sources of renewable and low cost substrate that can be efficiently fermented by microorganisms. The aim of this work was to critically assess selected bioenergy alternatives from organic solid waste, such as biohydrogen and bioelectricity, to evaluate their relative advantages and disadvantages in the context of biorefineries, and finally to indicate the trends for future research and development. Biorefining is the sustainable processing of biomass into a spectrum of marketable products, which means: energy, materials, chemicals, food and feed. Dark fermentation of organic wastes could be the beach-head of complete biorefineries that generate biohydrogen as a first step and could significantly influence the future of solid waste management. Series systems show a better efficiency than one-stage process regarding substrate conversion to hydrogen and bioenergy. The dark fermentation also produces fermented by-products (fatty acids and solvents), so there is an opportunity for further combining with other processes that yield more bioenergy. Photoheterotrophic fermentation is one of them: photosynthetic heterotrophs, such as non-sulfur purple bacteria, can thrive on the simple organic substances produced in dark fermentation and light, to give more H2. Effluents from photoheterotrophic fermentation and digestates can be processed in microbial fuel cells for bioelectricity production and methanogenic digestion for methane generation, thus integrating a diverse block of bioenergies. Several digestates from bioenergies could be used for bioproducts generation, such as cellulolytic enzymes and saccharification processes, leading to ethanol fermentation (another bioenergy), thus completing

  20. A role for bioelectric effects in the induction of bystander signals by ionizing radiation?

    Science.gov (United States)

    Mothersill, C; Moran, G; McNeill, F; Gow, M D; Denbeigh, J; Prestwich, W; Seymour, C B

    2007-04-03

    The induction of "bystander effects" i.e. effects in cells which have not received an ionizing radiation track, is now accepted but the mechanisms are not completely clear. Bystander effects following high and low LET radiation exposure are accepted but mechanisms are still not understood. There is some evidence for a physical component to the signal. This paper tests the hypothesis that bioelectric or biomagnetic phenomena are involved. Human immortalized skin keratinocytes and primary explants of mouse bladder and fish skin, were exposed directly to ionizing radiation or treated in a variety of bystander protocols. Exposure of cells was conducted by shielding one group of flasks using lead, to reduce the dose below the threshold of 2mGy (60)Cobalt gamma rays established for the bystander effect. The endpoint for the bystander effect in the reporter system used was reduction in cloning efficiency (RCE). The magnitude of the RCE was similar in shielded and unshielded flasks. When cells were placed in a Faraday cage the magnitude of the RCE was less but not eliminated. The results suggest that liquid media or cell-cell contact transmission of bystander factors may be only part of the bystander mechanism. Bioelectric or bio magnetic fields may have a role to play. To test this further, cells were placed in a Magnetic Resonance Imaging (MRI) machine for 10 min using a typical head scan protocol. This treatment also induced a bystander response. Apart from the obvious clinical relevance, the MRI results further suggest that bystander effects may be produced by non-ionizing exposures. It is concluded that bioelectric or magnetic effects may be involved in producing bystander signaling cascades commonly seen following ionizing radiation exposure.

  1. Electrical Stimulation: A Panacea for Disease?: DARPA Investigates New Bioelectrical Interfaces for a Range of Disorders.

    Science.gov (United States)

    Grifantini, Kristina

    2016-01-01

    It seems simple: send a small electrical current to a major nerve in the body and stimulate hormones and organs to react in the way you want. New efforts by research teams are doing just that, zapping peripheral nerves attached to major organs in the hopes of addressing problems as diverse as inflammatory bowel disease, chronic pain, and posttraumatic stress disorder. Thanks to the continued advance of smaller and more efficient electronics, researchers are finding new ways to develop implantable bioelectrical devices to treat a wide range of ailments.

  2. NOTE: Spatial dependence of the phase in localized bioelectrical impedance analysis

    Science.gov (United States)

    Shiffman, C. A.; Aaron, R.; Altman, A.

    2001-04-01

    The variety of phase functions, θ(z) = arctan X(z)/R(z), observed earlier on the thighs of healthy and seriously ill subjects via localized bioelectrical impedance analysis, can be represented by a model which combines realistic thigh shapes with homogeneous, axially symmetric conductivity tensors. While quantitative results depend sensitively on the way current is injected, it appears to be generally true that dθ/dz φz (and vice versa), where φr and φz are the phases of the radial and longitudinal conductivity components.

  3. Viability of a Bioelectrical Signal Acquisition System Energized by Cellphone with NFC.

    Science.gov (United States)

    Kay, Marcel Seiji; Iaione, Fábio

    2015-01-01

    Currently, smartphones are used in various systems in the medical field due to the presence of various features, notably Near Field Communication (NFC). NFC utilizes communication technology and an energy supply based on electromagnetic induction. One of the most common medical tests is the electrocardiogram (ECG), through which various heart diseases can be diagnosed. The objective of this study is to evaluate the feasibility of providing power to a bioelectrical signal acquisition module using a mobile phone with NFC. After testing it was indicated that it is possible to construct a passive module to acquire ECG signals using NFC mobile phone.

  4. A Software Tool for the Evaluation of the Behaviour of Bioelectrical Currents

    Directory of Open Access Journals (Sweden)

    Gianluca Fabbri

    2011-06-01

    Full Text Available A software tool has been developed in order to evaluate bioelectrical currents. The tool is able to provide a graphical representation of the behaviour of small currents emitted by characteristic points of the human body and captured through a non invasive probe previously developed. The software implementation combines a variety of graphical techniques to create a powerful system that will enable users to perform an accurate and reliable analysis of the emitted currents and to easily go on to further applications and research. This paper introduces the design and the main characteristics of the tool and shows significant measurement results.

  5. Lenguas bioelectrónicas en el análisis de polifenoles del vino

    OpenAIRE

    Cetó, Xavier; Valle Zafra, Manuel del

    2012-01-01

    El desarrollo y uso de una lengua bioelectrónica para llevar a cabo la discriminación y cuantificación de diferentes polifenoles (catecol, ácido cafeico y catequina) presentes en el vino és el objetivo de esta investigación desarrollada por el Departamento de Química de la UAB. En una primera aplicación, la discriminación de estos tuvo lugar en muestras sintéticas, mientras que en el siguiente paso se trabajó sobre muestras dopadas utilizando el vino como matriz. Esta discriminación puede ser...

  6. [Disturbed brain bioelectric activity in patients with liver encephalopathy and cirrhosis].

    Science.gov (United States)

    Alekseeva, A S; Beloborodova, E I; Rachkovskiĭ, M I; Filippova, L P; Lambrova, E G

    2009-01-01

    Brain bioelectric activity in 52 patients with liver cirrhosis (LC) was measured with respect to the degree of hepatic encephalopathy (HE) from the results of background and reactive EEG using West Haven criteria. As the severity of LC increased, signs of HE on background EEG appeared, index frequency and a-rhythm decreased and its amplitude increased. Reactive EEG was indicative of reduced duration, intensity, and decrement rate of responses to orientational loading (visual, somatosensorial, and auditory evoked potentials). It is concluded that EEG studies permit to predict dynamics of LC clinical course and may be used as an additional diagnostic tool, especially at the preclinical stage of HE.

  7. A model explaining synchronization of neuron bioelectric frequency under weak alternating low frequency magnetic field

    Science.gov (United States)

    del Moral, A.; Azanza, María J.

    2015-03-01

    A biomagnetic-electrical model is presented that explains rather well the experimentally observed synchronization of the bioelectric potential firing rate ("frequency"), f, of single unit neurons of Helix aspersa mollusc under the application of extremely low frequency (ELF) weak alternating (AC) magnetic fields (MF). The proposed model incorporates to our widely experimentally tested model of superdiamagnetism (SD) and Ca2+ Coulomb explosion (CE) from lipid (LP) bilayer membrane (SD-CE model), the electrical quadrupolar long range interaction between the bilayer LP membranes of synchronized neuron pairs, not considered before. The quadrupolar interaction is capable of explaining well the observed synchronization. Actual extension of our SD-CE-model shows that the neuron firing frequency field, B, dependence becomes not modified, but the bioelectric frequency is decreased and its spontaneous temperature, T, dependence is modified. A comparison of the model with synchronization experimental results of pair of neurons under weak (B0 ≅0.2-15 mT) AC-MF of frequency fM=50 Hz is reported. From the deduced size of synchronized LP clusters under B, is suggested the formation of small neuron networks via the membrane lipid correlation.

  8. Measurement of lean body mass using bioelectrical impedance analysis: a consideration of the pros and cons.

    Science.gov (United States)

    Sergi, Giuseppe; De Rui, Marina; Stubbs, Brendon; Veronese, Nicola; Manzato, Enzo

    2016-08-27

    The assessment of body composition has important applications in the evaluation of nutritional status and estimating potential health risks. Bioelectrical impedance analysis (BIA) is a valid method for the assessment of body composition. BIA is an alternative to more invasive and expensive methods like dual-energy X-ray absorptiometry, computerized tomography, and magnetic resonance imaging. Bioelectrical impedance analysis is an easy-to-use and low-cost method for the estimation of fat-free mass (FFM) in physiological and pathological conditions. The reliability of BIA measurements is influenced by various factors related to the instrument itself, including electrodes, operator, subject, and environment. BIA assumptions beyond its use for body composition are the human body is empirically composed of cylinders, FFM contains virtually all the water and conducting electrolytes in the body, and its hydration is constant. FFM can be predicted by BIA through equations developed using reference methods. Several BIA prediction equations exist for the estimation of FFM, skeletal muscle mass (SMM), or appendicular SMM. The BIA prediction models differ according to the characteristics of the sample in which they have been derived and validated in addition to the parameters included in the multiple regression analysis. In choosing BIA equations, it is important to consider the characteristics of the sample in which it has been developed and validated, since, for example, age- and ethnicity-related differences could sensitively affect BIA estimates.

  9. A model explaining synchronization of neuron bioelectric frequency under weak alternating low frequency magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Moral, A. del, E-mail: delmoral@unizar.es [Laboratorio de Magnetismo, Departamento de Física de Materia Condensada and Instituto de Ciencia de Materiales, Universidad de Zaragoza and Consejo Superior de Investigaciones Científicas, 50009 Zaragoza (Spain); Laboratorio de Magnetobiología, Departamento de Anatomía e Histología, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza (Spain); Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, 28223 Madrid (Spain); Azanza, María J., E-mail: mjazanza@unizar.es [Laboratorio de Magnetobiología, Departamento de Anatomía e Histología, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza (Spain); Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, 28223 Madrid (Spain)

    2015-03-01

    A biomagnetic-electrical model is presented that explains rather well the experimentally observed synchronization of the bioelectric potential firing rate (“frequency”), f, of single unit neurons of Helix aspersa mollusc under the application of extremely low frequency (ELF) weak alternating (AC) magnetic fields (MF). The proposed model incorporates to our widely experimentally tested model of superdiamagnetism (SD) and Ca{sup 2+} Coulomb explosion (CE) from lipid (LP) bilayer membrane (SD–CE model), the electrical quadrupolar long range interaction between the bilayer LP membranes of synchronized neuron pairs, not considered before. The quadrupolar interaction is capable of explaining well the observed synchronization. Actual extension of our SD–CE-model shows that the neuron firing frequency field, B, dependence becomes not modified, but the bioelectric frequency is decreased and its spontaneous temperature, T, dependence is modified. A comparison of the model with synchronization experimental results of pair of neurons under weak (B{sub 0}≅0.2–15 mT) AC-MF of frequency f{sub M}=50 Hz is reported. From the deduced size of synchronized LP clusters under B, is suggested the formation of small neuron networks via the membrane lipid correlation. - Highlights: • Neuron pair synchronization under low frequency alternating (AC) magnetic field (MF). • Superdiamagnetism and Ca{sup 2+} Coulomb explosion for AC MF effect in synchronized frequency. • Membrane lipid electrical quadrupolar pair interaction as synchronization mechamism. • Good agreement of model with electrophysiological experiments on mollusc Helix neurons.

  10. Bioelectrical impedance analysis for severe stroke patients with upper extremity hemiplegia

    Science.gov (United States)

    Yoo, Chanuk; Kim, Jaehyung; Yang, Yeongae; Lee, Jinsu; Jeon, Gyerok

    2016-01-01

    [Purpose] This study is to analyze bioimpedance parameters and occupational assessment for severe stroke patients with upper extremity hemiplegia. [Subjects and Methods] Experimental subjects were 20 hemiplegic stroke patients receiving rehabilitation therapy between November to October, 2015. Prediction marker (PM), and phase angle (θ), a nd characteristic frequency (fc) were measured using bioelectrical impedance spectroscopy (MultiScan 5000). Bioelectrical impedance vector analysis (BIVA) was also obtained from the bioimpedance data. Then, these values were compared with occupational assessment tools. [Results] A significant differences in PM, θ, fc, and BIVA were observed between paretic region and non-paretic region of 5 severe stroke patients. These results were in good agreement with occupational assessment (pinch and hand grip strength, and ADL by MBI). [Conclusion] There were significant differences in impedance parameters between paretic region and non-paretic region of 5 severe stroke patients with upper extremity hemiplegia. Thus, the BIA could be useful tool for evaluating hemiplegic stroke patients receiving the rehabilitation therapy in the clinical application. PMID:27821919

  11. Evaluation of segmental body composition by gender in obese children using bioelectric impedance analysis method

    Directory of Open Access Journals (Sweden)

    İhsan Çetin

    2015-12-01

    Full Text Available Objective: In this study, it was aimed to evaluate segmental body composition of children diagnosed with obesity using bioelectrical impedance analysis method in terms of different gender. Methods: 48 children, aged between 6-15 years, 21 of whom were boys while 27 were girls, diagnosed with obesity in Erciyes University Medical Faculty Department of Pediatric Endocrinology Outpatient Clinic were included in our study from April to June in 2011. Those over 95 percentile were defined as obese group. Tanita BC-418 device was used to analyze the body composition. Results: As a result of bioelectrical impedance analysis, lean body mass and body muscle mass were found to be statistically significantly higher in obese girls compared with obese boys. However, lean mass of the left arm, left leg muscle mass and basal metabolic rate were found to be statistically significantly lower in obese girls compared with obese boys. Conclusion: Consequently, it may be suggest that segmental analysis, where gender differences are taken into account, can provide proper exercise pattern and healthy way of weight loss in children for prevention of obesity and associated diseases including obesity and type 2 diabetics and cardiovascular diseases.

  12. [Effect of dosed diet restriction on physiological remodeling and bioelectric properties of bone].

    Science.gov (United States)

    Levashov, M I; Ianko, R V; Chaka, E G; Safonov, S L

    2014-07-01

    The effect of dosed diet restriction on the physiological remodeling and bioelectric properties of bone tissue was studied in 48 male Wistar rats 3- and 18-months of age. The rate of bone tissue apposition was studied by the dynamic histomorphometry method (intravital tetracycline labeling). Electric potentials on the periosteal surface of the freshly isolated femurs were recorded. The magnitude of dielectric loss factor was determined to assess the quality of bone tissue. The control rats received a standard diet. The experimental rats received a limited diet (60 % of the standard mass) for 28 days. The magnitude and rate of the bone tissue apposition on the endosteal and periosteal surface of the tibia were less by 38.4% and 122.7% respectively in experimental rats after dosed diet restriction. Electric potential in the metaphyseal-epiphyseal growth zones of the femur was 29.7% lower, and the dielectric loss factor increased by 15.8%. The bone tissue apposition rate and the electric potential magnitude were increased 10 days after completion of the dosed diet restriction. The magnitude of the dielectric loss factor decreased after returning to the standard diet. Key words: dosed diet restriction, bone, remodelling, bioelectric properties.

  13. 50 Hz-Sinusoidal magnetic field induced effects on the bioelectric activity of single unit neurone cells

    Science.gov (United States)

    Azanza, María. J.; Calvo, Ana C.; del Moral, A.

    2001-05-01

    Neurones recruiting and synchronized bioelectric activity recorded from Helix aspersa brain ganglia, under exposure to 50 Hz sinusoidal magnetic fields of 1-15 mT intensity, is reported. We show recruiting responses from single neurones and the synchronization of pairs of neurones activity. Experimental evidence and model theoretical explanation for the spreading of synchronization are presented.

  14. Validity of bioelectrical impedance analysis to assess fat-free mass in head and neck cancer patients: an exploratory study

    NARCIS (Netherlands)

    Jager-Wittenaar, Harriët; Dijkstra, Pieter U.; Earthman, Carrie P.; Krijnen, Wim P.; Langendijk, Johannes A.; Laan, Bernard F.A. M. van der; Pruim, Jan; Roodenburg, Jan L.N.

    2013-01-01

    Bioelectrical impedance analysis (BIA) may be used to assess fet free mass (FFM) with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of HNC patients. (Head

  15. Prediction of fat-free body mass from bioelectrical impedance among 9- to 11-year-old Swedish children

    DEFF Research Database (Denmark)

    Nielsen, Birgit Marie; Dencker, M; Ward, L

    2007-01-01

    -energy X-ray absorptiometry (DXA) as the reference measurement of body composition. METHODS: The study population consisted of 49 girls and 52 boys aged 9-11 years from Malmö, Sweden. Bioelectrical impedance was measured between hand and foot at 50 kHz. Predictive equations were developed by multiple...

  16. Electrochemical decolorization of methyl orange powered by bioelectricity from single-chamber microbial fuel cells.

    Science.gov (United States)

    Zhang, Baogang; Wang, Zhijun; Zhou, Xiang; Shi, Chunhong; Guo, Huaming; Feng, Chuanping

    2015-04-01

    Methyl orange (MO), a typical azo dye, is a well-known recalcitrant pollutant in dye wastewater. An aeration electrochemical system with single-chamber microbial fuel cell (MFC) as renewable power sources is proposed for MO decolorization. The enhanced color removal efficiency up to 90.4% within 360 min is observed with voltage across the aeration electrolytic reactor fixed at 700 mV. The results from gas chromatography-mass spectrometry (GC-MS) analysis indicate the destruction of MO, with generation of low molecular weight compounds such as benzene derivatives. Comparison experiments imply the indirect electrochemical oxidation of MO by generated H2O2 is mainly responsible for MO decolorization in present study. This work offers a cost-effective electrochemical method for enhancing electrochemical degradation of dyes with bioelectricity generated from MFCs.

  17. Alteration of bioelectrically-controlled processes in the embryo: a teratogenic mechanism for anticonvulsants.

    Science.gov (United States)

    Hernández-Díaz, Sonia; Levin, Michael

    2014-08-01

    Maternal use of anticonvulsants during the first trimester of pregnancy has been associated with an elevated risk of major congenital malformations in the offspring. Whether the increased risk is caused by the specific pharmacological mechanisms of certain anticonvulsants, the underlying epilepsy, or common genetic or environmental risk factors shared by epilepsy and malformations has been controversial. We hypothesize that anticonvulsant therapies during pregnancy that attain more successful inhibition of neurotransmission might lead to both better seizure control in the mother and stronger alteration of bioelectrically-controlled processes in the embryo that result in structural malformations. We propose that development of pharmaceuticals that do not alter cell resting transmembrane voltage levels could result in safer drugs.

  18. Spontaneous arsenic (III) oxidation with bioelectricity generation in single-chamber microbial fuel cells.

    Science.gov (United States)

    Li, Yunlong; Zhang, Baogang; Cheng, Ming; Li, Yalong; Hao, Liting; Guo, Huaming

    2016-04-05

    Arsenic is one of the most toxic elements commonly found in groundwater. With initial concentration of 200μgL(-1), spontaneous As(III) oxidation is realized completely during 7 days operation in single-chamber microbial fuel cells (MFCs) in the present study, with the maximum power density of 752.6±17mWm(-2). The product is less toxic and mobile As(V), which can be removed from aqueous solution more easily. High-throughput 16S rRNA gene pyrosequencing analysis indicates the existence of arsenic-resistant bacteria as Actinobacteria, Comamonas, Pseudomonas and arsenic-oxidizing bacteria as Enterobacter, with electrochemically active bacteria as Lactococcus, Enterobacter. They interact together and are responsible for As(III) oxidation and bioelectricity generation in MFCs. This study offers a potential attractive method for remediation of arsenic-polluted groundwater.

  19. Simultaneous microbial and electrochemical reductions of vanadium (V) with bioelectricity generation in microbial fuel cells.

    Science.gov (United States)

    Zhang, Baogang; Tian, Caixing; Liu, Ying; Hao, Liting; Liu, Ye; Feng, Chuanping; Liu, Yuqian; Wang, Zhongli

    2015-03-01

    Simultaneous microbial and electrochemical reductions of vanadium (V) with bioelectricity generation were realized in microbial fuel cells (MFCs). With initial V(V) concentrations of 75 mg/l and 150 mg/l in anolyte and catholyte, respectively, stable power output of 419±11 mW/m(2) was achieved. After 12h operation, V(V) concentration in the catholyte decreased to the value similar to that of the initial one in the anolyte, meanwhile it was nearly reduced completely in the anolyte. V(IV) was the main reduction product, which subsequently precipitated, acquiring total vanadium removal efficiencies of 76.8±2.9%. Microbial community analysis revealed the emergence of the new species of Deltaproteobacteria and Bacteroidetes as well as the enhanced Spirochaetes mainly functioned in the anode. This study opens new pathways to successful remediation of vanadium contamination.

  20. Optimization of enhanced bioelectrical reactor with electricity from microbial fuel cells for groundwater nitrate removal.

    Science.gov (United States)

    Liu, Ye; Zhang, Baogang; Tian, Caixing; Feng, Chuanping; Wang, Zhijun; Cheng, Ming; Hu, Weiwu

    2016-01-01

    Factors influencing the performance of a continual-flow bioelectrical reactor (BER) intensified by microbial fuel cells for groundwater nitrate removal, including nitrate load, carbon source and hydraulic retention time (HRT), were investigated and optimized by response surface methodology (RSM). With the target of maximum nitrate removal and minimum intermediates accumulation, nitrate load (for nitrogen) of 60.70 mg/L, chemical oxygen demand (COD) of 849.55 mg/L and HRT of 3.92 h for the BER were performed. COD was the dominant factor influencing performance of the system. Experimental results indicated the undistorted simulation and reliable optimized values. These demonstrate that RSM is an effective method to evaluate and optimize the nitrate-reducing performance of the present system and can guide mathematical models development to further promote its practical applications.

  1. Microbial fuel cells and microbial electrolysis cells for the production of bioelectricity and biomaterials.

    Science.gov (United States)

    Zhou, Minghua; Yang, Jie; Wang, Hongyu; Jin, Tao; Xu, Dake; Gu, Tingyue

    2013-01-01

    Today's global energy crisis requires a multifaceted solution. Bioenergy is an important part of the solution. The microbial fuel cell (MFC) technology stands out as an attractive potential technology in bioenergy. MFCs can convert energy stored in organic matter directly into bioelectricity. MFCs can also be operated in the electrolysis mode as microbial electrolysis cells to produce bioproducts such as hydrogen and ethanol. Various wastewaters containing low-grade organic carbons that are otherwise unutilized can be used as feed streams for MFCs. Despite major advances in the past decade, further improvements in MFC power output and cost reduction are needed for MFCs to be practical. This paper analysed MFC operating principles using bioenergetics and bioelectrochemistry. Several major issues were explored to improve the MFC performance. An emphasis was placed on the use of catalytic materials for MFC electrodes. Recent advances in the production of various biomaterials using MFCs were also investigated.

  2. Computationally efficient bioelectric field modeling and effects of frequency-dependent tissue capacitance

    Science.gov (United States)

    Tracey, Brian; Williams, Michael

    2011-06-01

    Standard bioelectric field models assume that the tissue is purely resistive and frequency independent, and that capacitance, induction, and propagation effects can be neglected. However, real tissue properties are frequency dependent, and tissue capacitance can be important for problems involving short stimulation pulses. A straightforward interpolation scheme is introduced here that can account for frequency-dependent effects, while reducing runtime over a direct computation by several orders of magnitude. The exact Helmholtz solution is compared to several approximate field solutions and is used to study neural stimulation. Results show that frequency-independent tissue capacitance always acts to attenuate the stimulation pulse, thereby increasing firing thresholds, while the dispersion effects introduced by frequency-dependent capacitance may decrease firing thresholds.

  3. Validation of bioelectrical-impedance analysis as a measurement of change in body composition in obesity

    Energy Technology Data Exchange (ETDEWEB)

    Kushner, R.F.; Kunigk, A.; Alspaugh, M.; Andronis, P.T.; Leitch, C.A.; Schoeller, D.A. (Univ. of Chicago, IL (USA))

    1990-08-01

    The bioelectrical-impedance-analysis (BIA) method accurately measures body composition in weight-stable subjects. This study validates the use of BIA to measure change in body composition. Twelve obese females underwent weight loss at a mean rate of 1.16 kg/wk. Body composition was measured by deuterium oxide dilution (D2O), BIA, and skinfold anthropometry (SFA) at baseline and at 5% decrements in weight. Highly significant correlations were obtained between D2O and BIA (r = 0.971) and between D2O and SFA (r = 0.932). Overall, BIA predicted change in fat-free mass with greater accuracy (to 0.4 kg) and precision (+/- 1.28 kg) than did anthropometry (to 0.8 kg and +/- 2.58 kg, respectively). We conclude that BIA is a useful clinical method for measuring change in body composition.

  4. Deciphering characteristics of bicyclic aromatics--mediators for reductive decolorization and bioelectricity generation.

    Science.gov (United States)

    Xu, Bin; Chen, Bor-Yann; Hsueh, Chung-Chuan; Qin, Lian-Jie; Chang, Chang-Tang

    2014-07-01

    This first-attempt study quantitatively assessed electron-mediating characteristics of bicyclic aromatics - 1-amino-2-naphthol, 4-amino-1-naphthol (i.e., decolorized intermediates of azo dyes - orange I and II) for color removal and power generation in MFCs. According to cyclic-voltammetric profiles, the presence of reduction and oxidation peak potentials clearly suggested a crucial role of these intermediates as electron-shuttling mediators. Shake-flask cultures also showed that appropriate accumulation of 1A2N, 4A1N apparently enhanced color-removal efficiencies of bacterial decolorization. This study clearly suggested that suitable supplementation of electrochemically active electron shuttle(s) to dye-bearing MFCs is a promising strategy to stimulate reductive decolorization and bioelectricity generation.

  5. Prediction of body composition of Iberian pigs by means bioelectrical impedance.

    Science.gov (United States)

    Daza, A; Mateos, A; Ovejero, I; Bote, C J López

    2006-01-01

    Twelve barrow Iberian pigs with an average weight at slaughter of 109.2kg were used to evaluate bioelectrical impedance procedures to predict the body composition of live pigs. Twelve hours before slaughter pigs were weighed, and a four-terminal body composition analyser (Model BIA-101, RJL Systems, Detroit, MI) was utilized to determine resistance (R(s) in Ω) and reactance (X(c) in Ω). The length values (L in cm) were measured between detector electrodes with a flexible steel tape. Twenty four hours after slaughter the left side of each carcass was separated using a scalpel into fat, lean, bone and skin. Multiple regression equations for estimating lean, fat, bone and skin amounts and lean, fat, bone and skin proportions with respect to slaughter weight were calculated. The live weight (LW) and L independent variables predicted 85.3% and 64.3% of the variability of the lean amount and lean proportion, respectively. The LW, X(c) and L variables accounted for 96% and 91.6% of the variation in fat quantity and fat proportion, respectively. The LW and R(s) accounted for 58.9% of the variation in bone amount, and the same variables predict 79.1% of the variability of bone percentage. The R(s) and L variables explained 68% of the variability of skin quantity and LW, R(s) and X(c) predicted 83.1% of the variation of skin proportion. Results from this experiment indicate that bioelectrical impedance may be of interest for body composition prediction of live Iberian pigs.

  6. Lipid and moisture content modeling of amphidromous Dolly Varden using bioelectrical impedance analysis

    Science.gov (United States)

    Stolarski, J.T.; Margraf, F.J.; Carlson, J.G.; Sutton, T.M.

    2014-01-01

    The physiological well-being or condition of fish is most commonly estimated from aspects of individual morphology. However, these metrics may be only weakly correlated with nutritional reserves stored as lipid, the primary form of accumulated energy in fish. We constructed and evaluated bioelectrical impedance analysis (BIA) models as an alternative method of assessing condition in amphidromous Dolly Varden Salvelinus malma collected from nearshore estuarine and lotic habitats of the Alaskan Arctic. Data on electrical resistance and reactance were collected from the lateral and ventral surfaces of 192 fish, and whole-body percent lipid and moisture content were determined using standard laboratory methods. Significant inverse relationships between temperature and resistance and reactance prompted the standardization of these data to a constant temperature using corrective equations developed herein. No significant differences in resistance or reactance were detected among spawning and nonspawning females after accounting for covariates, suggesting that electrical pathways do not intersect the gonads. Best-fit BIA models incorporating electrical variables calculated from the lateral and ventral surfaces produced the strongest associations between observed and model-predicted estimates of proximate content. These models explained between 6% and 20% more of the variability in laboratory-derived estimates of proximate content than models developed from single-surface BIA data and 32% more than models containing only length and weight data. While additional research is required to address the potential effects of methodological variation, bioelectrical impedance analysis shows promise as a way to provide high-quality, minimally invasive estimates of Dolly Varden lipid or moisture content in the field with only small increases in handling time.

  7. Multi-motion robots control based on bioelectric signals from single-channel dry electrode.

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    Shen, Hui-Min; Hu, Liang; Lee, Kok-Meng; Fu, Xin

    2015-02-01

    This article presents a multi-motion control system to help severe disabled people operate an auxiliary appliance using neck-up bioelectric signals measured by a single-channel dry electrode on the forehead. The single-channel dry-electrode multi-motion control system exhibits several practical advantages over its conventional counterparts that use multi-channel wet-electrodes; among the challenges is an effective technique to extract bioelectric features for reliable implementation of multi degrees-of-freedom motion control. Using both time and frequency characteristics of the single-channel dry-electrode measurements, motion commands are derived from multiple feature signals associated with concentration demands and different eye-blink actions for use in a two-level control strategy that has been developed to control predefined multi degrees-of-freedom motion trajectories. Test paradigms were designed to pre-calibrate the users' feature signals to statistically account for individual variances. Experimental trials were then carried out on able-bodied and disabled volunteers to validate the universal applicability of the algorithms. The classification success rates for two different eye-blink feature signals were approximately 95% with an average time of 2.4 s for executing a concentration feature signal. The single-channel dry-electrode-based technique has been validated on a 6-degree-of-freedom robot arm demonstrating its significant potentials to help patients suffering severe motor dysfunctions operate a multi-motion auxiliary appliance in everyday living where the ease of use is a priority.

  8. Evaluation of bioelectrical impedance analysis for identifying overweight individuals at increased cardiometabolic risk: a cross-sectional study.

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    Maxine J E Lamb

    Full Text Available OBJECTIVE: To investigate whether bioelectrical impedance analysis could be used to identify overweight individuals at increased cardiometabolic risk, defined as the presence of metabolic syndrome and/or diabetes. DESIGN AND METHODS: Cross-sectional study of a Scottish population including 1210 women and 788 men. The diagnostic performance of thresholds of percentage body fat measured by bioelectrical impedance analysis to identify people at increased cardiometabolic risk was assessed using receiver-operating characteristic curves. Odds ratios for increased cardiometabolic risk in body mass index categories associated with values above compared to below sex-specific percentage body fat thresholds with optimal diagnostic performance were calculated using multivariable logistic regression analyses. The validity of bioelectrical impedance analysis to measure percentage body fat in this population was tested by examining agreement between bioelectrical impedance analysis and dual-energy X-ray absorptiometry in a subgroup of individuals. RESULTS: Participants were aged 16-91 years and the optimal bioelectrical impedance analysis cut-points for percentage body fat for identifying people at increased cardiometabolic risk were 25.9% for men and 37.1% for women. Stratifying by these percentage body fat cut-points, the prevalence of increased cardiometabolic risk was 48% and 38% above the threshold and 24% and 19% below these thresholds for men and women, respectively. By comparison, stratifying by percentage body fat category had little impact on identifying increased cardiometabolic risk in normal weight and obese individuals. Fully adjusted odds ratios of being at increased cardiometabolic risk among overweight people with percentage body fat ≥ 25.9/37.1% compared with percentage body fat <25.9/37.1% as a reference were 1.93 (95% confidence interval: 1.20-3.10 for men and 1.79 (1.10-2.92 for women. CONCLUSION: Percentage body fat measured using

  9. Exploring characteristics of bioelectricity generation and dye decolorization of mixed and pure bacterial cultures from wine-bearing wastewater treatment.

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    Han, Jing-Long; Liu, Ying; Chang, Chang-Tang; Chen, Bor-Yann; Chen, Wen-Ming; Xu, Hui-Zhong

    2011-04-01

    This study uncovered microbial characteristics of bioelectricity generation and dye decolorization in single-chamber microbial fuel cells (MFCs) using activated sludge for wine-containing wastewater treatment. Phylogenetic tree analysis on 16S rRNA gene fragments indicated that the predominant strains on anodic biofilm in acclimatized MFCs were Gamma-Proteobacteria Aeromonas punctata NIU-P9, Pseudomonas plecoglossicida NIU-Y3, Pseudomonas koreensis NIU-X8, Acinetobacter junii NIU-Y8, Stenotrophomonas maltophila NIU-X2. Our findings showed that the current production capabilities of these pure strains were only ca. 10% of those of their mother activated sludge, indicating that synergistic interactions among microbes might be the most influential factor to maximize power generation in MFCs. Plus, these electrochemically active strains also performed reductive decolorization of C.I. reactive blue 160, suggesting that bioelectricity generation might be directly associated to azo dye decolorization to deal with electron transfer on anodic biofilm in MFCs.

  10. Dynamic of bioelectric activity back hypothalamus changes in conditions of pyroxan application on the background of stress-reaction developmen

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    T. G. Chaus

    2005-04-01

    Full Text Available The dynamic of changes of capacity of electroencephalogram’s rhythms back hypothalamus at animals of control group and group in stress conditions in parallel with rats who on a background of stress development accepted pyroxan is analyzed. The submitted results have shown influence of a pharmacological preparation pyroxan on bioelectric activity of back hypothalamus in stress conditions that restoration of electric activity under action of this preparation was more shown at 3 weeks of its application.

  11. Bioelectrical impedance phase angle as a prognostic indicator in breast cancer

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    Dahlk Sadie L

    2008-08-01

    Full Text Available Abstract Background Bioelectrical impedance analysis (BIA is an easy-to-use, non-invasive, and reproducible technique to evaluate changes in body composition and nutritional status. Phase angle, determined by bioelectrical impedance analysis (BIA, detects changes in tissue electrical properties and has been hypothesized to be a marker of malnutrition. Since malnutrition can be found in patients with breast cancer, we investigated the prognostic role of phase angle in breast cancer. Methods We evaluated a case series of 259 histologically confirmed breast cancer patients treated at Cancer Treatment Centers of America. Kaplan Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle independent of stage at diagnosis and prior treatment history. Survival was calculated as the time interval between the date of first patient visit to the hospital and the date of death from any cause or date of last contact/last known to be alive. Results Of 259 patients, 81 were newly diagnosed at our hospital while 178 had received prior treatment elsewhere. 56 had stage I disease at diagnosis, 110 had stage II, 46 had stage III and 34 had stage IV. The median age at diagnosis was 49 years (range 25 – 74 years. The median phase angle score was 5.6 (range = 1.5 – 8.9. Patients with phase angle 5.6 had 49.9 months (95% CI: 35.6 to 77.8; n = 130; the difference being statistically significant (p = 0.031. Multivariate Cox modeling, after adjusting for stage at diagnosis and prior treatment history found that every one unit increase in phase angle score was associated with a relative risk of 0.82 (95% CI: 0.68 to 0.99, P = 0.041. Stage at diagnosis (p = 0.006 and prior treatment history (p = 0.001 were also predictive of survival independent of each other and phase angle. Conclusion This study demonstrates that BIA-derived phase angle is an independent prognostic indicator in patients

  12. Evoked bioelectrical activity of efferent fibers of the sciatic nerve of white rats in experimental menopause

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    Rodinsky A.G.

    2016-03-01

    Full Text Available The aim of our work was analysis of the bioelectrical activity of efferent fibers of the sciatic nerve in experimental menopause condition. Experiments were performed on 25 female white rats, divided into experimental and control groups. Menopause was modeled by total ovariohysterectomy. In 120 days after modeling we had recorded evoked action potentials of fibers of isolated ventral root L5 induced by stimulation of sciatic nerve with rectangular pulses. Threshold, chronaxia, latency, amplitude and duration of the action potential (AP were analysed. Refractory phenomenon was investigated by applying paired stimuli at intervals of 2 to 20 ms. In the context of long-term hypoestrogenemy threshold of AP appearance was 55,32±7,69%, chronaxy – 115,09±2,67%, latent period – 112,62±1,74% as compared with the control animals (p<0.01. In conditions of paired stimuli applying the amplitude of response to the testing stimulus in animals with ovariohysterectomy at intervals 3 and 4 ms was 61,25±36,45% and 53,48±18,64% (p<0.05 respectively.

  13. Polarization Force Microscopy of the Cell-Mineral Interface: Insights Into the Bioelectric Signature

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    Bartosik, E. M.; Kendall, T. A.

    2007-12-01

    The success of bioremediation strategies is dependent upon effective monitoring of microorganisms in the subsurface. Induced polarization (IP) may represent a cost-effective, complementary technique to existing borehole-based microbe detection schemes. Recent studies show a significant, yet poorly understood IP effect associated with the presence of bacteria in aqueous and porous media. This effect is believed to be rooted in the physicochemical surface interactions between cells and minerals which we probe using polarization and electric force microscopy. Dispersions of the local permittivity inferred from polarization force data that was collected over a hydrated mineral surface correspond to dispersions modeled for a bacterium. In each case, absolute permittivities and frequency cut-off values increase with surface potential and ion mobility, respectively. Potentially similar polarization mechanisms between the inorganic and organic condition are inferred. Further polarization force microscopy measurements of the mineral-microbe interface will provide molecular-level insight that complements column and field-scale IP observations. Anticipated is a more comprehensive mechanisitic description of the bioelectric IP response that facilitates application of IP to bioremediation.

  14. Improvement of human keratinocyte migration by a redox active bioelectric dressing.

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    Jaideep Banerjee

    Full Text Available Exogenous application of an electric field can direct cell migration and improve wound healing; however clinical application of the therapy remains elusive due to lack of a suitable device and hence, limitations in understanding the molecular mechanisms. Here we report on a novel FDA approved redox-active Ag/Zn bioelectric dressing (BED which generates electric fields. To develop a mechanistic understanding of how the BED may potentially influence wound re-epithelialization, we direct emphasis on understanding the influence of BED on human keratinocyte cell migration. Mapping of the electrical field generated by BED led to the observation that BED increases keratinocyte migration by three mechanisms: (i generating hydrogen peroxide, known to be a potent driver of redox signaling, (ii phosphorylation of redox-sensitive IGF1R directly implicated in cell migration, and (iii reduction of protein thiols and increase in integrinαv expression, both of which are known to be drivers of cell migration. BED also increased keratinocyte mitochondrial membrane potential consistent with its ability to fuel an energy demanding migration process. Electric fields generated by a Ag/Zn BED can cross-talk with keratinocytes via redox-dependent processes improving keratinocyte migration, a critical event in wound re-epithelialization.

  15. Improvement of human keratinocyte migration by a redox active bioelectric dressing.

    Science.gov (United States)

    Banerjee, Jaideep; Das Ghatak, Piya; Roy, Sashwati; Khanna, Savita; Sequin, Emily K; Bellman, Karen; Dickinson, Bryan C; Suri, Prerna; Subramaniam, Vish V; Chang, Christopher J; Sen, Chandan K

    2014-01-01

    Exogenous application of an electric field can direct cell migration and improve wound healing; however clinical application of the therapy remains elusive due to lack of a suitable device and hence, limitations in understanding the molecular mechanisms. Here we report on a novel FDA approved redox-active Ag/Zn bioelectric dressing (BED) which generates electric fields. To develop a mechanistic understanding of how the BED may potentially influence wound re-epithelialization, we direct emphasis on understanding the influence of BED on human keratinocyte cell migration. Mapping of the electrical field generated by BED led to the observation that BED increases keratinocyte migration by three mechanisms: (i) generating hydrogen peroxide, known to be a potent driver of redox signaling, (ii) phosphorylation of redox-sensitive IGF1R directly implicated in cell migration, and (iii) reduction of protein thiols and increase in integrinαv expression, both of which are known to be drivers of cell migration. BED also increased keratinocyte mitochondrial membrane potential consistent with its ability to fuel an energy demanding migration process. Electric fields generated by a Ag/Zn BED can cross-talk with keratinocytes via redox-dependent processes improving keratinocyte migration, a critical event in wound re-epithelialization.

  16. Accuracy of segmental bioelectrical impedance analysis for predicting body composition in pre- and postmenopausal women.

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    Tanaka, Noriko I; Hanawa, Satoshi; Murakami, Haruka; Cao, Zhen-Bo; Tanimoto, Michiya; Sanada, Kiyoshi; Miyachi, Motohiko

    2015-01-01

    This study aimed to compare the accuracy for predicting body composition using single-frequent segmental bioelectrical impedance analysis (BIA) between pre- and postmenopausal women. A total f 559 Japanese women aged 30-88yr were divided into 4 groups by questionnaire: natural menopause, pathological menopause, regular menstruation, or irregular menstruation. The measurement values by dual-energy X-ray absorptiometry were used as a reference of the body composition. In terms of the results, regardless of the menopausal status, BIA slightly but significantly overestimated the percentage of body fat (standard error of estimate: 5.3%-6.7%) and the leg lean soft tissue mass (LSTM; 5.1%-6.1%), and underestimated the LSTM in the whole body (6.2%-7.6%) and arm (2.8%-3.7%). The absolute values of the predictive error for leg LSTM were significantly higher in postmenopausal groups than in the premenopausal ones. The corresponding values for the whole body and arm LSTM, and the percentage of body fat were higher in premenopausal groups than in postmenopausal ones. In conclusion, the predictive accuracy of BIA for postmenopausal women is not inferior to that for premenopausal ones, unless we target the leg LSTM.

  17. [Values of the phase angle by bioelectrical impedance; nutritional status and prognostic value].

    Science.gov (United States)

    Llames, L; Baldomero, V; Iglesias, M L; Rodota, L P

    2013-01-01

    Phase angle (PA) is the most established parameter from bioelectrical impedance analysis (BIA) for diagnosis of malnutrition and clinical prognosis, both associated with changes on cellular membrane integrity and alterations on fluids balance. PA expresses changes in quantity and quality of soft tissue mass (ie, cell membrane permeability and soft tissue hydration). A large body of clinical trials propose PA as a useful prognostic marker in clinical conditions like liver cirrhosis and breast, colon, pancreatic and lung cancer; positive association between PA and survival was also observed in surgical and HIV infected patients. Several authors suggest that PA can be an important tool in the evaluation of the clinical result or of the progression of the disease, and it can even be superior to other nutritional, biochemical or anthropometric indicators. Lack of reference values has limited its use in clinical and epidemiological situations. The purpose of this review is to describe PA reference values according to different clinical conditions as proposed in published scientific works.

  18. Bioelectricity generation and dewatered sludge degradation in microbial capacitive desalination cell.

    Science.gov (United States)

    Meng, Fanyu; Zhao, Qingliang; Na, Xiaolin; Zheng, Zhen; Jiang, Junqiu; Wei, Liangliang; Zhang, Jun

    2016-05-18

    Microbial desalination cell (MDC) is a new approach for the synergy in bioelectricity generation, desalination and organic waste treatment without additional power input. However, current MDC systems cause salt accumulation in anodic wastewater and sludge. A microbial capacitive desalination cell (MCDC) with dewatered sludge as anodic substrate was developed to address the salt migration problem and improve the sludge recycling value by special designed-membrane assemblies, which consisted of cation exchange membranes (CEMs), layers of activated carbon cloth (ACC), and nickel foam. Experimental results indicated that the maximum power output of 2.06 W/m(3) with open circuit voltage (OCV) of 0.942 V was produced in 42 days. When initial NaCl concentration was 2 g/L, the desalinization rate was about 15.5 mg/(L·h) in the first 24 h, indicating that the MCDC reactor was suitable to desalinize the low concentration salt solution rapidly. The conductivity of the anodic substrate decreased during the 42-day operation; the CEM/ACC/Ni assemblies could effectively restrict the salt accumulation in MCDC anode and promote dewatered sludge effective use by optimizing the dewatered sludge properties, such as organic matter, C/N, pH value, and electric conductivity (EC).

  19. Analysis of body water compartments after a short sauna bath using bioelectric impedance analysis.

    Science.gov (United States)

    Servidio, M-F; Mohamed, E I; Maiolo, C; Hereba, A T; Perrone, F; Garofano, P; Iacopino, L

    2003-10-01

    Studies have suggested that long-term sauna bathing may lower blood pressure in persons with hypertension by causing a direct loss of extracellular water and plasma minerals. The objective of the present study was to evaluate the effect of short-term sauna bathing on body water compartments as estimated by bioelectric impedance analysis (BIA). We recruited 15 men [mean age (+/-SD) of 23.93+/-5.12 years and mean body mass index (BMI) of 23.25+/-2.84 kg/m(2)] and 10 women matched for age and BMI. Total body resistance, reactance, and impedance were measured for all participants using BIA, at baseline, after a short sauna bath, and after a rest period. Total, extracellular, and intracellular water compartments were calculated using BIA formulae. There were no significant differences for any of the body water compartments when comparing the measurements taken before and after the sauna bath and after the rest period. However, it remains to be determined whether or not BIA is sensitive to rapid changes in water volume.

  20. [Study on effects of bioelectric parameters of rats in electromagnetic radiation of HV transmission line].

    Science.gov (United States)

    Zhang, Anying; Pang, Xiaofeng; Yuan, Ping

    2007-02-01

    With the development of economy and coming of information era, the chance of exposure to electromagnetic fields with various frequencies has been increased for every human. The effects of electromagnetic radiattion on human being's health are versatile. To study the effects of bioelctronic parameters of rats in the electromagnetic radiations of HV transmission line, EEG, ECG and CMAP were measured in rats exposed to simulating high-voltage transmission line electromagnetic radiation for over one year. Brain tissues were studied by Fourier transform infrared spectroscopy. The results showed that no significant difference between exposed group and control group in EEG; however the FT-infrared spectra of brain tissues were different; the ECG of the exposed animals was considerably altered. Significant slowing of heart rate was observed in those rates exposed to EMFs; the latent period of CMAP in exposed group were not different compared with those of control group however there was a significant difference in wave amplitude of CMAP between the exposed group and control group. All results indicated that there must be some effects on bioelectric parameters of rats exposed to electromagnetic radiation of high-voltage transmission line for a long time.

  1. Bioelectrical impedance vector analysis for evaluating zinc supplementation in prepubertal and healthy children

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    Márcia Marília Gomes Dantas

    2015-09-01

    Full Text Available Background: The prevalence of abnormal nutritional status has increased in children and adolescents. Nutritional assessment is important for monitoring the health and nutritional status. Bioelectrical impedance vector analysis (BIVA combines changes in tissue hydration and structure and body composition that can be assessed. Objectives: The objective of this study was to use BIVA to evaluate nutritional status in 60 prepubertal children, aged between 8 and 9 years, supplemented with zinc, to detect possible changes in body composition. Design: We performed a randomized, controlled, triple-blind study. The children were divided into the control group (CG; sorbitol 10%, n=29 or the experimental group (EG; 10 mg Zn/day, n=31, and the duration of the experiment was 3 months. Anthropometric assessments were performed for all of the children. Results: The body mass index-for-age increased after oral zinc supplementation in the EG (p=0.005. BIVA indicated that the CG demonstrated a tendency for dehydration and decreased soft tissue and the EG demonstrated a tendency for increased soft tissue, primarily the fat-free mass. After analyses of BIVA ellipses, we observed that this method could detect improvements in body composition in healthy children supplemented with zinc. Conclusions: These results suggest that BIVA could be an auxiliary method for studying a small population undergoing zinc intervention.

  2. Bioelectricity-assisted partial degradation of linear polyacrylamide in a bioelectrochemical system.

    Science.gov (United States)

    Cui, Yu-Zhi; Zhang, Jian; Sun, Min; Zhai, Lin-Feng

    2015-01-01

    The wide application of water-soluble linear polyacrylamides (PAMs) can cause serious environmental pollution. Biological treatment of PAMs receives very limited efficiency due to their recalcitrance to the microbial degradation. Here, we show the bioelectrochemical system (BES) can be used as an effective strategy to improve the biodegradation efficiency of PAMs. A linear PAM with viscosity-average molecular weight of 5 × 10(6) was treated in the anodic chamber of BES reactor, and the change of PAM structure during the degradation process was investigated. The anodic bacteria in the BES demonstrated abilities to utilize the PAM as the sole carbon and nitrogen source to generate electricity. Both the anode-attached and planktonic bacteria contributed to the electricity generation, while the anode-attached community exhibited stronger electron transfer ability than the planktonic one. The closed-circuit and open-circuit operations of the BES reactor obtained chemical oxygen demand (COD) removal efficiencies of 32.5 and 7.4 %, respectively, implying the generation of bioelectricity could enhance the biodegradation of PAM. Structure analysis suggested the carbon chain of PAM was partially degraded in the BES, producing polymeric products with lower molecular weight. The microbial cleavage of the carbon chain was proposed to start from the "head-to-head" linkages and end with the formation of ether bonds.

  3. Enhanced bioelectricity harvesting in microbial fuel cells treating food waste leachate produced from biohydrogen fermentation.

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    Choi, Jeongdong; Ahn, Youngho

    2015-05-01

    Microbial fuel cells (MFCs) treating the food waste leachate produced from biohydrogen fermentation were examined to enhance power generation and energy recovery. In batch mode, the maximum voltage production was 0.56 V and the power density reached 1540 mW/m(2). The maximum Coulombic efficiency (CEmax) and energy efficiency (EE) in the batch mode were calculated to be 88.8% and 18.8%, respectively. When the organic loading rate in sequencing batch mode varied from 0.75 to 6.2 g COD/L-d (under CEmax), the maximum power density reached 769.2 mW/m(2) in OLR of 3.1 g COD/L-d, whereas higher energy recovery (CE=52.6%, 0.346 Wh/g CODrem) was achieved at 1.51 g COD/L-d. The results demonstrate that readily biodegradable substrates in biohydrogen fermentation can be effectively used for the enhanced bioelectricity harvesting of MFCs and a MFC coupled with biohydrogen fermentation is of great benefit on higher electricity generation and energy efficiency.

  4. Bioelectrical impedance analysis determination of water content and distribution in the horse.

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    Latman, Neal S; Keith, Natalie; Nicholson, Alan; Davis, Michael

    2011-06-01

    A horse's hydration status is critical to its health. The accurate and quantitative determination of it has been problematic because of size, length and density of hair, and uneven topography. The objective of this study was to validate a bioelectrical impedance analysis (BIA) method for objectively quantifying hydration status. Monofrequency BIA values and simple biometric measurements were used to construct predictive equations for total body water, plasma, extracellular, and intra-cellular fluid volumes. These predictive equations were correlated with standard body fluid dilution reference methods. The result was an accuracy of ±0.64% for total body water, ±0.17% for plasma volume, ±1.91% for extra-cellular fluid, and ±0.57% for intra-cellular fluid compartments. Less than 5 min was required for all of the measurements and determinations. Therefore, it appears that an accurate measurement of body fluid distribution can be performed on horses using a fast, easy, non-invasive, inexpensive BIA method.

  5. Smartphone-Based Bioelectrical Impedance Analysis Devices for Daily Obesity Management

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    Ahyoung Choi

    2015-09-01

    Full Text Available Current bioelectric impedance analysis (BIA systems are often large, cumbersome devices which require strict electrode placement on the user, thus inhibiting mobile capabilities. In this work, we developed a handheld BIA device that measures impedance from multiple frequencies (5 kHz~200 kHz with four contact electrodes and evaluated the BIA device against standard body composition analysis systems: a dual-energy X-ray absorptiometry (DXA system (GE Lunar Prodigy, GE Healthcare, Buckinghamshire, UK and a whole-body BIA system (InBody S10, InBody, Co. Ltd, Seoul, Korea. In the study, 568 healthy participants, varying widely in body mass index, age, and gender, were recruited at two research centers: the Samsung Medical Center (SMC in South Korea and the Pennington Biomedical Research Center (PBRC in the United States. From the measured impedance data, we analyzed individual body fat and skeletal muscle mass by applying linear regression analysis against target reference data. Results indicated strong correlations of impedance measurements between the prototype pathways and corresponding InBody S10 electrical pathways (R = 0.93, p < 0.0001. Additionally, body fat estimates from DXA did not yield significant differences (p > 0.728 (paired t-test, DXA mean body fat 29.45 ± 10.77 kg, estimated body fat 29.52 ± 12.53 kg. Thus, this portable BIA system shows a promising ability to estimate an individual’s body composition that is comparable to large stationary BIA systems.

  6. A Useful Tool As a Medical Checkup in a General Population—Bioelectrical Impedance Analysis

    Science.gov (United States)

    Enomoto, Mika; Adachi, Hisashi; Fukami, Ako; Kumagai, Eita; Nakamura, Sachiko; Nohara, Yume; Kono, Shoko; Nakao, Erika; Morikawa, Nagisa; Tsuru, Tomoko; Sakaue, Akiko; Fukumoto, Yoshihiro

    2017-01-01

    Accumulation of visceral fat leads to metabolic syndrome and increases risks of cerebro-cardiovascular diseases, which should be recognized and improved at the early stage in general population. Accurate measurement of visceral fat area (VFA) is commonly performed by the abdominal cross-sectional image measured by computed tomography scan, which is, however, limited due to the radiation exposure. The bioelectrical impedance analysis (OMRON, HDS-2000 DUALSCANR) has been recently developed to measure VFA, which is more easily accessible modality. In the present study, we investigated the clinical usefulness of DUALSCANR in 226 subjects who received health examination, including blood chemistries, electrocardiography, cardio, and carotid ultrasonography. VFA was measured within only just 5 min. Average of VFA was 83.5 ± 36.3 cm2 in men, and 64.8 ± 28.0 cm2 in women, which was correlated to weight (r = 0.7404, p < 0.0001), body mass index (BMI) (r = 0.7320, p < 0.0001), and waist circumstance (r = 0.7393, p < 0.0001). In multivariate analyses, VFA was significantly associated with weight (p < 0.0001), BMI (p < 0.0001), and waist circumstance (p < 0.0001). Compared to the group of smaller waist and normal BMI, VFA was significantly increased (p < 0.0001) in the group of larger waist and obese subjects. In conclusion, these results indicated that DUALSCANR is useful to measure VFA easily in general population, even in a large number of subjects. PMID:28210619

  7. Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment.

    Science.gov (United States)

    Tazegül Pekin, A; Yılmaz, S A; Kerimoğlu, Ö Seçilmiş; Çelik, G; Doğan, N U; Beyhekim, H; Çelik, Ç

    2015-01-01

    More than half of pregnant women suffer from nausea and vomiting, in 0.5-1% of the pregnant women, if nausea and vomiting are severe and persistent, condition can progress to hyperemesis. We evaluated the fluid volume parameters in pregnant women with hyperemesis gravidarum, before and after treatment using the bioelectrical impedance vectors. A total of 70 pregnant women who had weight loss exceeding 5% of pre-pregnancy body weight were recruited for the study in the first trimester. The measurement of multi-frequency bioelectrical impedance analysis parameters was performed on the day of hospitalisation before any treatment and after treatment at 24 h and 72 h with the same procedure. Total body water, extracellular water, intracellular water, and fat-free mass index increased after treatment at 24 h (P treatment (11.3 ± 2.1 at enrolment, 5.1 ± 1.4 at 24 h and 4.3 ± 1.1 at 72 h) (P hyperemesis gravidarum, significant body composition changes occur and fluid replacement therapy performed during a short period of time, such as 24 h, provides improvement in body composition.

  8. Bioelectrical impedance analysis and anthropometry for the determination of body composition in rats: effects of high-fat and high-sucrose diets

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    Larissa Rodrigues Neto Angéloco

    2012-06-01

    Full Text Available OBJECTIVE: The aim of the present study was to determine the impedance of Wistar rats treated with high-fat and high-sucrose diets and correlate their biochemical and anthropometric parameters with chemical analysis of the carcass. METHODS: Twenty-four male Wistar rats were fed a standard (AIN-93, high-fat (50% fat or high-sucrose (59% of sucrose diet for 4 weeks. Abdominal and thoracic circumference and body length were measured. Bioelectrical impedance analysis was used to determine resistance and reactance. Final body composition was determined by chemical analysis. RESULTS: Higher fat intake led to a high percentage of liver fat and cholesterol and low total body water in the High-Fat group, but these changes in the biochemical profile were not reflected by the anthropometric measurements or bioelectrical impedance analysis variables. Anthropometric and bioelectrical impedance analysis changes were not observed in the High-Sucrose group. However, a positive association was found between body fat and three anthropometric variables: body mass index, Lee index and abdominal circumference. CONCLUSION: Bioelectrical impedance analysis did not prove to be sensitive for detecting changes in body composition, but body mass index, Lee index and abdominal circumference can be used for estimating the body composition of rats.

  9. Evaluation of body composition in COPD patients using multifrequency bioelectrical impedance analysis

    Science.gov (United States)

    de Blasio, Francesca; de Blasio, Francesco; Miracco Berlingieri, Giulia; Bianco, Andrea; La Greca, Marta; Franssen, Frits M E; Scalfi, Luca

    2016-01-01

    Background Multifrequency bioelectrical impedance analysis (MF-BIA) is a technique that measures body impedance (Z) at different frequencies (5, 10, 50, 100, and 250 kHz). Body composition may be estimated using empirical equations, which include BIA variables or, alternatively, raw BIA data may provide direct information on water distribution and muscle quality. Objectives To compare raw MF-BIA data between COPD patients and controls and to study their relationship with respiratory and functional parameters in COPD patients. Methods MF-BIA was performed (Human Im-Touch analyzer) in 212 COPD patients and 115 age- and BMI-matched controls. Fat-free mass (FFM) and fat mass were estimated from BIA data, and low- to high-frequency (5 kHz/250 kHz) impedance ratio was calculated. Physical fitness, lung function and respiratory muscle strength were also assessed in COPD patients. Results After adjusting for age, weight, and body mass index, FFM and the 5/250 impedance ratio were lower in COPD patients (P<0.001) and were negatively affected by disease severity. In both male and female patients, the 5/250 impedance ratio was significantly correlated mainly with age (r=−0.316 and r=−0.346, respectively). Patients with a 5/250 impedance ratio below median value had lower handgrip strength (P<0.001), 6-minute walk distance (P<0.005), respiratory muscle strength (P<0.005), forced expiratory volume in 1 second (P<0.05) and vital capacity (P<0.005). Finally, the 5/250 impedance ratio was reduced (P<0.05) in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) III and IV (compared to those with GOLD I and II) or a BODE index between 6 and 10 points (compared to those with BODE index between 1 and 5 points). Conclusion MF-BIA may be a useful tool for assessing body composition and nutritional status in COPD patients. In particular, the impedance ratio could give valuable information on cellular integrity and muscle quality.

  10. Bioelectrical impedance analysis in clinical practice: implications for hepatitis C therapy BIA and hepatitis C

    Directory of Open Access Journals (Sweden)

    Kahraman Alisan

    2010-08-01

    Full Text Available Abstract Background Body composition analysis using phase angle (PA, determined by bioelectrical impedance analysis (BIA, reflects tissue electrical properties and has prognostic value in liver cirrhosis. Objective of this prospective study was to investigate clinical use and prognostic value of BIA-derived phase angle and alterations in body composition for hepatitis C infection (HCV following antiviral therapy. Methods 37 consecutive patients with HCV infection were enrolled, BIA was performed, and PA was calculated from each pair of measurements. 22 HCV genotype 3 patients treated for 24 weeks and 15 genotype 1 patients treated for 48 weeks, were examined before and after antiviral treatment and compared to 10 untreated HCV patients at 0, 24, and 48 weeks. Basic laboratory data were correlated to body composition alterations. Results Significant reduction in body fat (BF: 24.2 ± 6.7 kg vs. 19.9 ± 6.6 kg, genotype1; 15.4 ± 10.9 kg vs. 13.2 ± 12.1 kg, genotype 3 and body cell mass (BCM: 27.3 ± 6.8 kg vs. 24.3 ± 7.2 kg, genotype1; 27.7 ± 8.8 kg vs. 24.6 ± 7.6 kg, genotype 3 was found following treatment. PA in genotype 3 patients was significantly lowered after antiviral treatment compared to initial measurements (5.9 ± 0.7° vs. 5.4 ± 0.8°. Total body water (TBW was significantly decreased in treated patients with genotype 1 (41.4 ± 7.9 l vs. 40.8 ± 9.5 l. PA reduction was accompanied by flu-like syndromes, whereas TBW decline was more frequently associated with fatigue and cephalgia. Discussion BIA offers a sophisticated analysis of body composition including BF, BCM, and TBW for HCV patients following antiviral regimens. PA reduction was associated with increased adverse effects of the antiviral therapy allowing a more dynamic therapy application.

  11. Integrative assessment of kick boxers’ brain blood circulation and bio-electrical activity in conditions of correction technologies’ application

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    Romanov Y.N.

    2016-06-01

    Full Text Available Purpose: to scientifically substantiate the role of para-vertebral impacts on blood circulation and bio-electrical activity of kick boxers’ cortex. Material: in the research participated kick boxers (main group, n=62 and university students (control group, n=25 of 18-23 years’ age. Assessment of para-vertebral impacts with device Armos and classic massage was fulfilled with the help of the following methodic: trans-cranial dopplerography of head main arteries and cortex EEG of the tested. Results: it was found that with the help of para-vertebral impacts by device Armos linear velocity of cerebral blood flow reduces to normal limits and in- and inter-hemispheres’ interaction strength increases. Conclusions: para-vertebral impacts by device Armos activate integrative processes and inter-hemispheres’ interactions of different cortex areas of kick boxers. It can witness about better formation of functional systems, ensuring sports efficiency.

  12. 食蚊鱼的生物电场特征%THE BIOELECTRIC FIELD OF GAMBUSIA AFFINIS

    Institute of Scientific and Technical Information of China (English)

    张旭光; 宋佳坤; 张国胜; 范纯新; 郭弘艺; 王晓杰

    2011-01-01

    Sturgeon is an ancestor electrosensory fish which is able to sense the electric fields of prey animals and other sources. The character of bioelectric fields in environment is an important stimulus to investigate the electrosensory information processing in the brain. However, there were a few documents on bioelectric fields. In this study, the bioelectric fields of Gambusia affinis were measured in living fish, which was used as prey fish of Siberian Sturgeon in laboratory and the common small fish in southern China. They were measured and charactered in three experimental groups: single fish group, pair in same direction group and pair in opposite direction group. The bioelectric field of single fish showed typical features of dipole field, with relative potential up to (-24±2.4) uV on head and (21 ±1.6) uV on tail. There was (4.2±0.8) uV alternating current electric with 1-3 Hz on head which was corresponded with the respiratory rhythm of the fish. In other two experimental groups, the direct current electric fields were larger than the single fish group (P<0.05). However, the alternating current electric field of single fish group was significant bigger than pair in opposite direction group (3.8±0.7) uV but smaller than pairs in same direction group (4.5±0.8) uV (P<0.01). It suggested that the schooling fish could evade the predators by modulating the alternating current respiratory potential. It was maybe a kind of ancestral anti-predator strategy for fish to meet the passive electroreception, and further research would carry on electrophysiology.%文章采用活体记录的方法测量了食蚊鱼(Gambusia affinis)的生物电场.实验分单尾鱼、两尾鱼同向和两尾鱼反向三组测量,每组10个重复.结果表明:单尾鱼的生物电场表现为头负、尾正的偶极子直流电场,头部相对电势为(-24±2.4)μ v,尾部为(21±1 6)μ v,且头部附近产生1-3 Hz与呼吸频率对应的交流呼吸电场,大小为(4.2±0.8)μV.两尾

  13. GHG emission factors for bioelectricity, biomethane, and bioethanol quantified for 24 biomass substrates with consequential life-cycle assessment

    DEFF Research Database (Denmark)

    Tonini, Davide; Hamelin, Lorie; Alvarado-Morales, Merlin

    2016-01-01

    Greenhouse gas (GHG) emission savings from biofuels dramatically depend upon the source of energy displaced and the effects induced outside the energy sector, for instance land-use changes (LUC). Using consequential life-cycle assessment and including LUC effects, this study provides GHG emission...... factors (EFs) for bioelectricity, biomethane, and bioethanol produced from twenty-four biomasses (from dedicated crops to residues of different origin) under a fossil and a non-fossil energy system. Accounting for numerous variations in the pathways, a total of 554 GHG EFs were quantified. The results...... showed that, important GHG savings were obtained with residues and seaweed, both under fossil and non-fossil energy systems. For high-yield perennial crops (e.g. willow and Miscanthus), GHG savings were achieved only under fossil energy systems. Biofuels from annual crops and residues that are today used...

  14. Evaluation of body composition in COPD patients using multifrequency bioelectrical impedance analysis

    Directory of Open Access Journals (Sweden)

    de Blasio F

    2016-09-01

    Full Text Available Francesca de Blasio,1 Francesco de Blasio,2,3 Giulia Miracco Berlingieri,2 Andrea Bianco,3,4 Marta La Greca,1 Frits M E Franssen,5 Luca Scalfi1 1Department of Public Health, Medical School, “Federico II” University of Naples, 2Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, 3Department of Medicine and Health Sciences “V Tiberio”, University of Molise, Campobasso, 4Department of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy; 5Department of Research and Education, CIRO, Horn, the NetherlandsBackground: Multifrequency bioelectrical impedance analysis (MF-BIA is a technique that measures body impedance (Z at different frequencies (5, 10, 50, 100, and 250 kHz. Body composition may be estimated using empirical equations, which include BIA variables or, alternatively, raw BIA data may provide direct information on water distribution and muscle quality.Objectives: To compare raw MF-BIA data between COPD patients and controls and to study their relationship with respiratory and functional parameters in COPD patients.Methods: MF-BIA was performed (Human Im-Touch analyzer in 212 COPD patients and 115 age- and BMI-matched controls. Fat-free mass (FFM and fat mass were estimated from BIA data, and low- to high-frequency (5 kHz/250 kHz impedance ratio was calculated. Physical fitness, lung function and respiratory muscle strength were also assessed in COPD patients.Results: After adjusting for age, weight, and body mass index, FFM and the 5/250 impedance ratio were lower in COPD patients (P<0.001 and were negatively affected by disease severity. In both male and female patients, the 5/250 impedance ratio was significantly correlated mainly with age (r=−0.316 and r=−0.346, respectively. Patients with a 5/250 impedance ratio below median value had lower handgrip strength (P<0.001, 6-minute walk distance (P<0.005, respiratory muscle strength (P<0.005, forced

  15. Validity of segmental bioelectrical impedance analysis for estimating fat-free mass in children including overweight individuals.

    Science.gov (United States)

    Ohta, Megumi; Midorikawa, Taishi; Hikihara, Yuki; Masuo, Yoshihisa; Sakamoto, Shizuo; Torii, Suguru; Kawakami, Yasuo; Fukunaga, Tetsuo; Kanehisa, Hiroaki

    2017-02-01

    This study examined the validity of segmental bioelectrical impedance (BI) analysis for predicting the fat-free masses (FFMs) of whole-body and body segments in children including overweight individuals. The FFM and impedance (Z) values of arms, trunk, legs, and whole body were determined using a dual-energy X-ray absorptiometry and segmental BI analyses, respectively, in 149 boys and girls aged 6 to 12 years, who were divided into model-development (n = 74), cross-validation (n = 35), and overweight (n = 40) groups. Simple regression analysis was applied to (length)(2)/Z (BI index) for each of the whole-body and 3 segments to develop the prediction equations of the measured FFM of the related body part. In the model-development group, the BI index of each of the 3 segments and whole body was significantly correlated to the measured FFM (R(2) = 0.867-0.932, standard error of estimation = 0.18-1.44 kg (5.9%-8.7%)). There was no significant difference between the measured and predicted FFM values without systematic error. The application of each equation derived in the model-development group to the cross-validation and overweight groups did not produce significant differences between the measured and predicted FFM values and systematic errors, with an exception that the arm FFM in the overweight group was overestimated. Segmental bioelectrical impedance analysis is useful for predicting the FFM of each of whole-body and body segments in children including overweight individuals, although the application for estimating arm FFM in overweight individuals requires a certain modification.

  16. Inter-sport variability of muscle volume distribution identified by segmental bioelectrical impedance analysis in four ball sports

    Directory of Open Access Journals (Sweden)

    Yamada Y

    2013-04-01

    Full Text Available Yosuke Yamada,1,2 Yoshihisa Masuo,3 Eitaro Nakamura,4 Shingo Oda5 1Laboratory of Sports and Health Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Japan Society for the Promotion of Science, Tokyo, Japan; 3Waseda University Research Institute for Elderly Health, Saitama, Japan; 4Department of Sport Science, Kyoto Iken College of Medicine and Health, Kyoto, Japan; 5Faculty of Health and Well-being, Kansai University, Osaka, Japan Abstract: The aim of this study was to evaluate and quantify differences in muscle distribution in athletes of various ball sports using segmental bioelectrical impedance analysis (SBIA. Participants were 115 male collegiate athletes from four ball sports (baseball, soccer, tennis, and lacrosse. Percent body fat (%BF and lean body mass were measured, and SBIA was used to measure segmental muscle volume (MV in bilateral upper arms, forearms, thighs, and lower legs. We calculated the MV ratios of dominant to nondominant, proximal to distal, and upper to lower limbs. The measurements consisted of a total of 31 variables. Cluster and factor analyses were applied to identify redundant variables. The muscle distribution was significantly different among groups, but the %BF was not. The classification procedures of the discriminant analysis could correctly distinguish 84.3% of the athletes. These results suggest that collegiate ball game athletes have adapted their physique to their sport movements very well, and the SBIA, which is an affordable, noninvasive, easy-to-operate, and fast alternative method in the field, can distinguish ball game athletes according to their specific muscle distribution within a 5-minute measurement. The SBIA could be a useful, affordable, and fast tool for identifying talents for specific sports. Keywords: discriminant analysis, cluster and factor analysis, segmental bioelectrical impedance analysis, baseball, lacrosse

  17. Bioelectricity Generation and Bioremediation of an Azo-Dye in a Microbial Fuel Cell Coupled Activated Sludge Process.

    Science.gov (United States)

    Khan, Mohammad Danish; Abdulateif, Huda; Ismail, Iqbal M; Sabir, Suhail; Khan, Mohammad Zain

    2015-01-01

    Simultaneous bioelectricity generation and dye degradation was achieved in the present study by using a combined anaerobic-aerobic process. The anaerobic system was a typical single chambered microbial fuel cell (SMFC) which utilizes acid navy blue r (ANB) dye along with glucose as growth substrate to generate electricity. Four different concentrations of ANB (50, 100, 200 and 400 ppm) were tested in the SMFC and the degradation products were further treated in an activated sludge post treatment process. The dye decolorization followed pseudo first order kinetics while the negative values of the thermodynamic parameter ∆G (change in Gibbs free energy) shows that the reaction proceeds with a net decrease in the free energy of the system. The coulombic efficiency (CE) and power density (PD) attained peak values at 10.36% and 2,236 mW/m2 respectively for 200 ppm of ANB. A further increase in ANB concentrations results in lowering of cell potential (and PD) values owing to microbial inhibition at higher concentrations of toxic substrates. Cyclic voltammetry studies revealed a perfect redox reaction was taking place in the SMFC. The pH, temperature and conductivity remain 7.5-8.0, 27(±2°C and 10.6-18.2 mS/cm throughout the operation. The biodegradation pathway was studied by the gas chromatography coupled with mass spectroscopy technique, suggested the preferential cleavage of the azo bond as the initial step resulting in to aromatic amines. Thus, a combined anaerobic-aerobic process using SMFC coupled with activated sludge process can be a viable option for effective degradation of complex dye substrates along with energy (bioelectricity) recovery.

  18. Bioelectricity Generation and Bioremediation of an Azo-Dye in a Microbial Fuel Cell Coupled Activated Sludge Process.

    Directory of Open Access Journals (Sweden)

    Mohammad Danish Khan

    Full Text Available Simultaneous bioelectricity generation and dye degradation was achieved in the present study by using a combined anaerobic-aerobic process. The anaerobic system was a typical single chambered microbial fuel cell (SMFC which utilizes acid navy blue r (ANB dye along with glucose as growth substrate to generate electricity. Four different concentrations of ANB (50, 100, 200 and 400 ppm were tested in the SMFC and the degradation products were further treated in an activated sludge post treatment process. The dye decolorization followed pseudo first order kinetics while the negative values of the thermodynamic parameter ∆G (change in Gibbs free energy shows that the reaction proceeds with a net decrease in the free energy of the system. The coulombic efficiency (CE and power density (PD attained peak values at 10.36% and 2,236 mW/m2 respectively for 200 ppm of ANB. A further increase in ANB concentrations results in lowering of cell potential (and PD values owing to microbial inhibition at higher concentrations of toxic substrates. Cyclic voltammetry studies revealed a perfect redox reaction was taking place in the SMFC. The pH, temperature and conductivity remain 7.5-8.0, 27(±2°C and 10.6-18.2 mS/cm throughout the operation. The biodegradation pathway was studied by the gas chromatography coupled with mass spectroscopy technique, suggested the preferential cleavage of the azo bond as the initial step resulting in to aromatic amines. Thus, a combined anaerobic-aerobic process using SMFC coupled with activated sludge process can be a viable option for effective degradation of complex dye substrates along with energy (bioelectricity recovery.

  19. Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

    DEFF Research Database (Denmark)

    Palle, Stine Skov; Tang Møllehave, Line; Kadkhoda, Zahra Taheri

    2016-01-01

    Background: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients...... during the course of their treatments. Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer...

  20. Examination of the bioelectrical activity of the masticatory muscles during Angle’s Class II division 2 therapy with an activator

    Directory of Open Access Journals (Sweden)

    Petrović Đorđe

    2014-01-01

    Full Text Available Background/Aim. The muscles of the orofacial region have great influence on the development of dentition and occlusion formation. It is known that improper function of these muscles is one of the major etiological factors in malocclusion. A correlation between function disorders of orofacial muscle and occlusion disorders has been confirmed, as well as a correlation between the bioelectric activity of the masticatory muscles, recorded by electromyography, and bite force upon maximal voluntary contraction of these muscles. The aim of the study was to analyze the bioelectriacal activity of temporal and masseter muscles. Methods. The sample consisted of 100 subjects of both sexes, divided into the control group (n = 30 with neutral and complete dental arches, and the study group (n = 70 of patients with distal occlusion. Electromyographic measurement of bioelectric potentials in all the subjects was conducted for the examined muscles in the physiologic rest position, central mandible occlusion, and during maximal voluntary contraction of muscles and saliva swallowing, in Angle Class I and II/2 occlusal relation-ships, prior to treatment, after one year of the orthodontic treatment and after the treatment with an activator. Results. Comparing the values of thebioelectrical activity in the control and the study group before the treatment, a decreased muscle activity was established in all the three positions in the study group. After the first year of orthodontic treatment the results showed an elevation in the bioelectrical activity in both muscles. After treatment with an activator, the bioelectrical activity in both muscles in the study group was higher than before the treatment, as it is confirmed by a positive highly significant coefficient of correlation. Conclusion. In all the three measured positions of the mandible with Angle Class II/2 malocclusion, bioelectrical activity was lowest at baseline and increased during the first year of

  1. Simultaneous bioelectricity generation and decolorization of methyl orange in a two-chambered microbial fuel cell and bacterial diversity.

    Science.gov (United States)

    Guo, Wei; Feng, Jinglan; Song, Hong; Sun, Jianhui

    2014-10-01

    The objectives of this study were to investigate the simultaneous bioelectricity generation and decolorization of methyl orange (MO) in the anode chamber of microbial fuel cells (MFCs) in a wide concentration range (from 50 to 800 mg L(-1)) and to reveal the microbial communities on the anode after the MFC was operated continuously for more than 6 months using MO-glucose mixtures as fuel. Interestingly, the added MO played an active role in the production of electricity. The maximum voltage outputs were 565, 658, 640, 629, 617, and 605 mV for the 1 g L(-1) glucose with 0, 50, 100, 200, 300, and 500 mg L(-1) of MO, respectively. The results of three groups of comparison experiments showed that accelerated decolorization of methyl orange (MO) was achieved in the MFC as compared to MFC in open circuit mode and MFC without extra carbon sources. The decolorization efficiency decreased with an increase of MO concentration in the studied concentration range for the dye load increased. A 454 high-throughput pyrosequencing revealed the microbial communities. Geobacter genus known to generate electricity was detected. Bacteroidia class, Desulfovibrio, and Trichococcus genus, which were most likely responsible for degrading methyl orange, were also detected.

  2. Study on the mechanism of Bioelectric Recognition Assay: evidence for immobilized cell membrane interactions with viral fragments.

    Science.gov (United States)

    Kintzios, S; Bem, F; Mangana, O; Nomikou, K; Markoulatos, P; Alexandropoulos, N; Fasseas, C; Arakelyan, V; Petrou, A-L; Soukouli, K; Moschopoulou, G; Yialouris, C; Simonian, A

    2004-11-01

    The Bioelectric Recognition Assay (BERA) is a whole-cell based biosensing system that detects the electric response of cultured cells, suspended in a gel matrix, to various ligands, which bind to the cell and/or affect its physiology. Previous studies have demonstrated the potential application of this method for rapid, inexpensive detection of viruses in a crude sample. However, the understanding, so far, of the fundamental processes that take place during cell-virus interactions within the probe has been rather limited. In the present study, we combined electrophysiological and fluorescence microscopical assays, so that we can prove that animal and plant cells immobilized in BERA sensors respond to different viruses primarily by changing their membrane potential. The response of immobilized cells against different viruses did not depend on the virus ability to penetrate the cell, but was modified after binding each virus to a virus-specific antibody or removal of its coat protein after treatment with a protease. Consequently, we were able to assay the presence of a virus in its complete form or fragments thereof. Combination of immunological recognition with the electrophysiological response of immobilized cells allows for a considerable increase of the specificity of the BERA biosensory assay. In addition, rather than simply detect the presence of a protein or genomic sequence, the method can help gain information on the bioactivity of a virus.

  3. GHG emission factors for bioelectricity, biomethane, and bioethanol quantified for 24 biomass substrates with consequential life-cycle assessment.

    Science.gov (United States)

    Tonini, Davide; Hamelin, Lorie; Alvarado-Morales, Merlin; Astrup, Thomas Fruergaard

    2016-05-01

    Greenhouse gas (GHG) emission savings from biofuels dramatically depend upon the source of energy displaced and the effects induced outside the energy sector, for instance land-use changes (LUC). Using consequential life-cycle assessment and including LUC effects, this study provides GHG emission factors (EFs) for bioelectricity, biomethane, and bioethanol produced from twenty-four biomasses (from dedicated crops to residues of different origin) under a fossil and a non-fossil energy system. Accounting for numerous variations in the pathways, a total of 554 GHG EFs were quantified. The results showed that, important GHG savings were obtained with residues and seaweed, both under fossil and non-fossil energy systems. For high-yield perennial crops (e.g. willow and Miscanthus), GHG savings were achieved only under fossil energy systems. Biofuels from annual crops and residues that are today used in the feed sector should be discouraged, as LUC GHG emissions exceeded any GHG savings from displacing conventional energy sources.

  4. Optimisation of the Low-Frequency Response of a Multi-stage Bioelectric Amplifier for Electrocardiogram (ECG Recording

    Directory of Open Access Journals (Sweden)

    Burke Martin J.

    2016-01-01

    Full Text Available This paper reports the optimisation of the low-frequency response of a multi-stage bioelectric amplifier intended for use in the measurement of the human electrocardiogram (ECG using high-impedance un-gelled electrodes. The frequency response was optimised to meet international performance requirements for electrocardiographic recorders, in particular the International Electrotechnical Commission 60601 standards [1,2]. The pole and zero locations of a multi-stage amplifier configuration were optimised to meet both time and frequency domain specifications. The optimum assignment for a three stage amplifier, having two differential stages and a differential-to-single-ended conversion stage was established by evaluating the performance of a number of circuit configurations. The optimum configuration was found to be two differential stages with a gain of 20dB each and a differential-to single-ended output stage with unity gain. The -3dB pole is placed at 0.028Hz and a zero at 0.0028Hz in the first and second stages to give an overall -3dB bandwidth of 0.043Hz. In addition, the pole of the input ac coupling network was placed at 0.0028Hz in order to meet the undershoot and recovery slope requirements in the narrow pulse response.

  5. Measuring body composition in dogs using multifrequency bioelectrical impedance analysis and dual energy X-ray absorptiometry.

    Science.gov (United States)

    Rae, L S; Vankan, D M; Rand, J S; Flickinger, E A; Ward, L C

    2016-06-01

    Thirty-five healthy, neutered, mixed breed dogs were used to determine the ability of multifrequency bioelectrical impedance analysis (MFBIA) to predict accurately fat-free mass (FFM) in dogs using dual energy X-ray absorptiometry (DXA)-measured FFM as reference. A second aim was to compare MFBIA predictions with morphometric predictions. MFBIA-based predictors provided an accurate measure of FFM, within 1.5% when compared to DXA-derived FFM, in normal weight dogs. FFM estimates were most highly correlated with DXA-measured FFM when the prediction equation included resistance quotient, bodyweight, and body condition score. At the population level, the inclusion of impedance as a predictor variable did not add substantially to the predictive power achieved with morphometric variables alone; in individual dogs, impedance predictors were more valuable than morphometric predictors. These results indicate that, following further validation, MFBIA could provide a useful tool in clinical practice to objectively measure FFM in canine patients and help improve compliance with prevention and treatment programs for obesity in dogs.

  6. Extensions to a manifold learning framework for time-series analysis on dynamic manifolds in bioelectric signals

    Science.gov (United States)

    Erem, Burak; Martinez Orellana, Ramon; Hyde, Damon E.; Peters, Jurriaan M.; Duffy, Frank H.; Stovicek, Petr; Warfield, Simon K.; MacLeod, Rob S.; Tadmor, Gilead; Brooks, Dana H.

    2016-04-01

    This paper addresses the challenge of extracting meaningful information from measured bioelectric signals generated by complex, large scale physiological systems such as the brain or the heart. We focus on a combination of the well-known Laplacian eigenmaps machine learning approach with dynamical systems ideas to analyze emergent dynamic behaviors. The method reconstructs the abstract dynamical system phase-space geometry of the embedded measurements and tracks changes in physiological conditions or activities through changes in that geometry. It is geared to extract information from the joint behavior of time traces obtained from large sensor arrays, such as those used in multiple-electrode ECG and EEG, and explore the geometrical structure of the low dimensional embedding of moving time windows of those joint snapshots. Our main contribution is a method for mapping vectors from the phase space to the data domain. We present cases to evaluate the methods, including a synthetic example using the chaotic Lorenz system, several sets of cardiac measurements from both canine and human hearts, and measurements from a human brain.

  7. The accuracy of hand-to-hand bioelectrical impedance analysis in predicting body composition in college-age female athletes.

    Science.gov (United States)

    Esco, Michael R; Olson, Michele S; Williford, Henry N; Lizana, Suheil N; Russell, Angela R

    2011-04-01

    The purpose of this investigation was to determine the accuracy of hand-to-hand bioelectrical impedance analysis (BIA) for estimating body composition in college-age female athletes using dual-energy X-ray absorptiometry (DEXA) as the criterion measure. Forty National Association for Intercollegiate Athletics college female athletes volunteered to participate in this study. For each participant, total body fat percentage (BF%) and fat-free mass (FFM) were obtained via BIA and DEXA. The mean BF% and FFM values obtained by BIA were compared with the criterion DEXA measure. The DEXA strongly correlated to the BIA for BF% (r = 0.74, R2 = 0.55, SEE = 3.60, and p < 0.01) and FFM (r = 0.84, R2 = 0.71, SEE = 2.45, p < 0.01). However, when compared with the DEXA, the mean values for BIA were significantly lower for BF% (DEXA = 27.6 ± 5.3%, BIA = 22.5 ± 3.5%, p < 0.01) and higher for FFM (DEXA = 47.2 ± 4.5 kg, BIA = 50.6 ± 4.6 kg, p < 0.01). The results of this investigation indicate that hand-to-hand BIA significantly underestimates BF% and overestimated FFM in college-age female athletes when compared with the criterion DEXA. Practitioners should use caution when analyzing body composition with hand-held BIA in a population of athletic women.

  8. Modulating Endogenous Electric Currents in Human Corneal Wounds—A Novel Approach of Bioelectric Stimulation Without Electrodes

    Science.gov (United States)

    Reid, Brian; Graue-Hernandez, Enrique O.; Mannis, Mark J.; Zhao, Min

    2011-01-01

    Purpose To measure electric current in human corneal wounds and test the feasibility of pharmacologically enhancing the current to promote corneal wound healing. Methods Using a noninvasive vibrating probe, corneal electric current was measured before and after wounding of the epithelium of donated postmortem human corneas. The effects of drug aminophylline and chloride-free solution on wound current were also tested. Results Unwounded cornea had small outward currents (0.07 μA/cm2). Wounding increased the current more than 5 fold (0.41 μA/cm2). Monitoring the wound current over time showed that it seemed to be actively regulated and maintained above normal unwounded levels for at least 6 hours. The time course was similar to that previously measured in rat cornea. Drug treatment or chloride-free solution more than doubled the size of wound currents. Conclusions Electric current at human corneal wounds can be significantly increased with aminophylline or chloride-free solution. Because corneal wound current directly correlates with wound healing rate, our results suggest a role for chloride-free and/or aminophylline eyedrops to enhance healing of damaged cornea in patients with reduced wound healing such as the elderly or diabetic patient. This novel approach offers bioelectric stimulation without electrodes and can be readily tested in patients. PMID:21099404

  9. Bioelectricity production from food waste leachate using microbial fuel cells: effect of NaCl and pH.

    Science.gov (United States)

    Li, Xiao Min; Cheng, Ka Yu; Wong, Jonathan W C

    2013-12-01

    Microbial fuel cells are a promising technology for simultaneous treatment and energy recovery from food waste leachate. This study evaluates the effects of NaCl (0-150 mM) and pH on the treatment of food waste leachate using microbial fuel cells. The food waste leachate amended with 100mM NaCl enabled the highest maximum power density (1000 mW/m(3)) and lowest internal resistance (371Ω). Increasing the anodic pH gradually from acidic to alkaline conditions (pH 4-9) resulted in a gradual increase in maximum power density to 9956 mW/m(3) and decrease in internal cell resistance to 35.3Ω. The coulombic efficiency obtained under acidic conditions was only 17.8%, but increased significantly to 60.0% and 63.4% in the neutral and alkaline pH's MFCs, respectively. Maintaining a narrow pH window (6.3-7.6) was essential for efficient bioelectricity production and COD removal using microbial fuel cells for the treatment of food waste leachate.

  10. [Approaches to reduce the retroaction of long-term monitoring of bioelectric events in ergonomic field studies (author's transl)].

    Science.gov (United States)

    Zipp, P; Faber, S

    1979-10-01

    When monitoring bioelectric signals the surface electrodes can cause a retroaction on the subject thereby introducing an error of measurement. There are two types of retroaction: physical and psycho-physiological. A physical retroaction due to the hydration process of the skin occurs if 'wet' electrodes are used for the recording of the skin conductance level (SCL) causing a continuous drift of the SCL and a decrease in sensitivity to SCL changes. Therefore a dry electrode was developed with improved performance: It exhibits less sensitivity to motion, is not subject to polarization, and features better SCL long-term stability. When recording the electrocardiogram or the electromyogram a psychophysiological retroaction occurs due to the annoyance caused by the skin-irritating abrading techniques in order to decrease the skin impedance and reduce the motion artifact. In an attempt to abandon the skin preparation whenever permissible without sacrificing the measurement accuracy a performance estimation procedure was developed. Basing on the information on the signal frequency content, the electrode contact area, the required accuracy of measurement and the amplifier input impedance a decision on the necessity of skin preparation is made. Moreover, the results of a study are reported investigating the reduction of motion artifacts by means of electrode design and appropriate electrode jelly formulation.

  11. 器官形态发生探索Ⅰ:生物电与形态发生%Exploration of organ morphogenesis Ⅰ:Bioelectricity and morphogenesis

    Institute of Scientific and Technical Information of China (English)

    赵海平; 刘振; 陈广信; 李春义

    2015-01-01

    Summary Morphogenesis is a biological process that involves the shape development and pattern maintenance of an organism . Morphogenetic information is needed for morphogenetic primordial developing to construct an appropriate three‐dimension (3D) structure , which includes three aspects :positional information , prepatterning information , and epigenetic information . The essence and mechanism of morphogenetic information is the primary condition to understand morphogenesis . This paper reviews the latest research progress of morphogenetic field , bioelectricity and organ morphogenesis . Mechanism of organ morphogenesis has not been well understood in life science field . Advances in molecular biology were expected to solve this mystery , but proved to be a failure . Interestingly , recent study showed that organ morphogenesis was regulated by bioelectricity at multiple levels on lower animals , for example:1) Artificially setting the resting potential in embryonic frog cells can lead to eye formation at any part of amphibian body ;2) bioelectricity can regulate regeneration of tail and ectopic limb formation in Xenopus tadpoles ;3) bioelectricity determines regeneration pattern of amputated planaria fragments on whether head or tail . Therefore , organ fate was obviously determined by bioelectric state of morphogenetic primordia . Bioelectricity is the essence of organ morphogenetic information , which is a landmark advance in this field that the bioelectricity encodes organ morphogenesis . It is an inspiration that electric is used as a signal code in communication for understanding work mechanism of bioelectric code . For example , Morse alphabet and binary , which consist of electrical signal , are used in telegram system and computer system respectively . Nowadays , 3D structures can be made by 3D printer , and the machine can execute commands encoded by binary . The physical process of bioelectricity encoding organ morphogenesis in animal bodies is

  12. Foot-to-foot bioelectrical impedance accurately tracks direction of adiposity change in overweight and obese 7- to 13-year-old children.

    Science.gov (United States)

    Kasvis, Popi; Cohen, Tamara R; Loiselle, Sarah-Ève; Kim, Nicolas; Hazell, Tom J; Vanstone, Catherine A; Rodd, Celia; Plourde, Hugues; Weiler, Hope A

    2015-03-01

    Body composition measurements are valuable when evaluating pediatric obesity interventions. We hypothesized that foot-to-foot bioelectrical impedance analysis (BIA) will accurately track the direction of adiposity change, but not magnitude, in part due to differences in fat patterning. The purposes of this study were to examine the accuracy of body composition measurements of overweight and obese children over time using dual-energy x-ray absorptiometry (DXA) and BIA and to determine if BIA accuracy was affected by fat patterning. Eighty-nine overweight or obese children (48 girls, 41 boys, age 7-13 years) participating in a randomized controlled trial providing a family-centered, lifestyle intervention, underwent DXA and BIA measurements every 3 months. Bland-Altman plots showed a poor level of agreement between devices for baseline percent body fat (%BF; mean, 0.398%; +2SD, 8.685%; -2SD, -7.889%). There was overall agreement between DXA and BIA in the direction of change over time for %BF (difference between visits 3 and 1: DXA -0.8 ± 0.5%, BIA -0.7 ± 0.5%; P = 1.000) and fat mass (FM; difference between visits 3 and 1: DXA 0.7 ± 0.5 kg, BIA 0.6 ± 0.5 kg; P = 1.000). Bioelectrical impedance analysis measurements of %BF and FM at baseline were significantly different in those with android and gynoid fat (%BF: 35.9% ± 1.4%, 32.2% ± 1.4%, P < .003; FM: 20.1 ± 0.8 kg, 18.4 ± 0.8, P < .013). Bioelectrical impedance analysis accurately reports the direction of change in FM and FFM in overweight and obese children; inaccuracy in the magnitude of BIA measurements may be a result of fat patterning differences.

  13. Effects of interleukin-18 on bioelectric activity of rat atrial cardiomyocytes under normal conditions and during gradual stretching of the tissue.

    Science.gov (United States)

    Mitrokhin, V M; Makarenko, E Yu; Abramochkin, D V; Sutyagin, P V; Kamkin, A G

    2014-08-01

    Effects of IL-18 (50 ng/ml) on bioelectric activity of rat atrial cardiomyocytes under normal conditions and after gradual stretching of the tissue was studied using microelectrode technique. It was shown that in 85% experiments, IL-18 increased the duration of action potential at the level of 25, 50, and 90% repolarization without changing the magnitude of the resting potential, amplitude and repetition rate of action potentials, and cardiomyocyte contraction force. In addition, IL-18 abolished mechanically induced changes in the shape of action potentials during stretching.

  14. Comparison of Standing Posture Bioelectrical Impedance Analysis with DXA for Body Composition in a Large, Healthy Chinese Population

    Science.gov (United States)

    Chen, Kuen-Tsann; Chen, Yu-Yawn; Wang, Chia-Wei; Chuang, Chih-Lin; Chiang, Li-Ming; Lai, Chung-Liang; Lu, Hsueh-Kuan; Dwyer, Gregory B.; Chao, Shu-Ping; Shih, Ming-Kuei; Hsieh, Kuen-Chang

    2016-01-01

    Bioelectrical impedance analysis (BIA) is a common method for assessing body composition in research and clinical trials. BIA is convenient but when compared with other reference methods, the results have been inconclusive. The level of obesity degree in subjects is considered to be an important factor affecting the accuracy of the measurements. A total of 711 participants were recruited in Taiwan and were sub-grouped by gender and levels of adiposity. Regression analysis and Bland-Altman analysis were used to evaluate the agreement of the measured body fat percentage (BF%) between BIA and DXA. The BF% measured by the DXA and BIA methods (Tanita BC-418) were expressed as BF%DXA and BF%BIA8, respectively. A one-way ANOVA was used to test the differences in BF% measurements by gender and levels of adiposity. The estimated BF%BIA8 and BF%DXA in the all subjects, male and female groups were all highly correlated (r = 0.934, 0.901, 0.916, all P< 0.001). The average estimated BF%BIA8 (22.54 ± 9.48%) was significantly lower than the average BF%DXA (26.26 ± 11.18%). The BF%BIA8 was overestimated in the male subgroup (BF%DXA< 15%), compared to BF%DXA by 0.45%, respectively. In the other subgroups, the BF%BIA8 values were all underestimated. Standing BIA estimating body fat percentage in Chinese participants have a high correlation, but underestimated on normal and high obesity degree in both male and female subjects. PMID:27467065

  15. Reliability of Calf Bioelectrical Impedance Spectroscopy and Magnetic-Resonance-Imaging-Acquired Skeletal Muscle Hydration Measures in Healthy People

    Directory of Open Access Journals (Sweden)

    Anuradha Sawant

    2013-01-01

    Full Text Available Purpose. The purpose of this study was to investigate the test-retest reliability, relative variability, and agreement between calf bioelectrical impedance-spectroscopy (cBIS acquired extracellular fluid (ECF, intracellular fluid (ICF, total water and the ratio of ECF : ICF, magnetic-resonance-imaging (MRI acquired transverse relaxation times (T2, and apparent diffusion coefficient (ADC of calf muscles of the same segment in healthy individuals. Methods. Muscle hydration measures were collected in 32 healthy individuals on two occasions and analyzed by a single rater. On both occasions, MRI measures were collected from tibialis anterior (TA, medial (MG, and lateral gastrocnemius (LG and soleus muscles following the cBIS data acquired using XiTRON Hydra 4200 BIS device. The intraclass correlation coefficients (ICC2,1, coefficient of variation (CV, and agreement between MRI and cBIS data were also calculated. Results. ICC2,1 values for cBIS, T2, and ADC ranged from 0.56 to 0.92, 0.96 to 0.99, and 0.05 to 0.56, respectively. Relative variability between measures (CV ranged from 14.6 to 25.6% for the cBIS data and 4.2 to 10.0% for the MRI-acquired data. The ratio of ECF : ICF could significantly predict T2 of TA and soleus muscles. Conclusion. MRI-acquired measures of T2 had the highest test-retest reliability of muscle hydration with the least error and variation on repeated testing. Hence, T2 of a muscle is the most reliable and stable outcome measure for evaluating individual muscle hydration.

  16. The investigation of the some body parameters of obese and (obese+diabetes) patients with using bioelectrical impedance analysis techniques

    Science.gov (United States)

    Yerlikaya, Emrah; Karageçili, Hasan; Aydin, Ruken Zeynep

    2016-04-01

    Obesity is a key risk for the development of hyperglycemia, hypertension, hyperlipidemia, insulin resistance and is totally referred to as the metabolic disorders. Diabetes mellitus, a metabolic disorder, is related with hyperglycemia, altered metabolism of lipids, carbohydrates and proteins. The minimum defining characteristic feature to identify diabetes mellitus is chronic and substantiated elevation of circulating glucose concentration. In this study, it is aimed to determine the body composition analyze of obese and (obese+diabetes) patients.We studied the datas taken from three independent groups with the body composition analyzer instrument. The body composition analyzer calculates body parameters, such as body fat ratio, body fat mass, fat free mass, estimated muscle mass, and base metabolic rate on the basis of data obtained by Dual Energy X-ray Absorptiometry using Bioelectrical Impedance Analysis. All patients and healthy subjects applied to Siirt University Medico and their datas were taken. The Statistical Package for Social Sciences version 21 was used for descriptive data analysis. When we compared and analyzed three groups datas, we found statistically significant difference between obese, (obese+diabetes) and control groups values. Anova test and tukey test are used to analyze the difference between groups and to do multiple comparisons. T test is also used to analyze the difference between genders. We observed the statistically significant difference in age and mineral amount peducation level among the illiterate and university graduates; fat mass kg, fat percentage, internal lubrication, body mass index, water percentage, protein mass percentage, mineral percentage p<0.05, significant statistically difference were observed. This difference especially may result of a sedentary lifestyle.

  17. Effects of various organic carbon sources on simultaneous V(V) reduction and bioelectricity generation in single chamber microbial fuel cells.

    Science.gov (United States)

    Hao, Liting; Zhang, Baogang; Cheng, Ming; Feng, Chuanping

    2016-02-01

    Four ordinary carbon sources affecting V(V) reduction and bioelectricity generation in single chamber microbial fuel cells (MFCs) were investigated. Acetate supported highest maximum power density of 589.1mW/m(2), with highest V(V) removal efficiency of 77.6% during 12h operation, compared with glucose, citrate and soluble starch. Exorbitant initial V(V) concentration led to lower V(V) removal efficiencies and power outputs. Extra addition of organics had little effect on the improvement of MFCs performance. V(V) reduction and bioelectricity generation were enhanced and then suppressed by the increase of conductivity. The larger the external resistance, the higher the V(V) removal efficiencies and voltage outputs. High-throughput 16S rRNA gene pyrosequencing analysis implied the accumulation of Enterobacter which had the capabilities of V(V) reduction, electrochemical activity and fermentation, accompanied with other functional species as Pseudomonas, Spirochaeta, Sedimentibacter and Dysgonomonas. This study steps forward to remediate V(V) contaminated environment based on MFC technology.

  18. Hand-to-Hand Model for Bioelectrical Impedance Analysis to Estimate Fat Free Mass in a Healthy Population

    Directory of Open Access Journals (Sweden)

    Hsueh-Kuan Lu

    2016-10-01

    Full Text Available This study aimed to establish a hand-to-hand (HH model for bioelectrical impedance analysis (BIA fat free mass (FFM estimation by comparing with a standing position hand-to-foot (HF BIA model and dual energy X-ray absorptiometry (DXA; we also verified the reliability of the newly developed model. A total of 704 healthy Chinese individuals (403 men and 301 women participated. FFM (FFMDXA reference variables were measured using DXA and segmental BIA. Further, regression analysis, Bland–Altman plots, and cross-validation (2/3 participants as the modeling group, 1/3 as the validation group; three turns were repeated for validation grouping were conducted to compare tests of agreement with FFMDXA reference variables. In male participants, the hand-to-hand BIA model estimation equation was calculated as follows: FFMmHH = 0.537 h2/ZHH − 0.126 year + 0.217 weight + 18.235 (r2 = 0.919, standard estimate of error (SEE = 2.164 kg, n = 269. The mean validated correlation coefficients and limits of agreement (LOAs of the Bland–Altman analysis of the calculated values for FFMmHH and FFMDXA were 0.958 and −4.369–4.343 kg, respectively, for hand-to-foot BIA model measurements for men; the FFM (FFMmHF and FFMDXA were 0.958 and −4.356–4.375 kg, respectively. The hand-to-hand BIA model estimating equation for female participants was FFMFHH = 0.615 h2/ZHH − 0.144 year + 0.132 weight + 16.507 (r2 = 0.870, SEE = 1.884 kg, n = 201; the three mean validated correlation coefficient and LOA for the hand-to-foot BIA model measurements for female participants (FFMFHH and FFMDXA were 0.929 and −3.880–3.886 kg, respectively. The FFMHF and FFMDXA were 0.942 and −3.511–3.489 kg, respectively. The results of both hand-to-hand and hand-to-foot BIA models demonstrated similar reliability, and the hand-to-hand BIA models are practical for assessing FFM.

  19. Performance of Two Bioelectrical Impedance Analyses in the Diagnosis of Overweight and Obesity in Children and Adolescents: The FUPRECOL Study

    Science.gov (United States)

    Ramírez-Vélez, Robinson; Correa-Bautista, Jorge Enrique; Martínez-Torres, Javier; González-Ruíz, Katherine; González-Jiménez, Emilio; Schmidt-RioValle, Jacqueline; Garcia-Hermoso, Antonio

    2016-01-01

    This study aimed to determine thresholds for percentage of body fat (BF%) corresponding to the cut-off values for overweight/obesity as recommended by the International Obesity Task Force (IOTF), using two bioelectrical impedance analyzers (BIA), and described the likelihood of increased cardiometabolic risk in our cohort defined by the IOTF and BF% status. Participants included 1165 children and adolescents (54.9% girls) from Bogotá (Colombia). Body mass index (BMI) was calculated from height and weight. BF% of each youth was assessed first using the Tanita BC-418® followed by a Tanita BF-689®. The sensitivity and specificity of both devices and their ability to correctly classify children as overweight/obesity (≥2 standard deviation), as defined by IOTF, was investigated using receiver operating characteristic (ROC) by sex and age groups (9–11, 12–14, and 13–17 years old); Area under curve (AUC) values were also reported. For girls, the optimal BF% threshold for classifying into overweight/obesity was found to be between 25.2 and 28.5 (AUC = 0.91–0.97) and 23.9 to 26.6 (AUC = 0.90–0.99) for Tanita BC-418® and Tanita BF-689®, respectively. For boys, the optimal threshold was between 16.5 and 21.1 (AUC = 0.93–0.96) and 15.8 to 20.6 (AUC = 0.92–0.94) by Tanita BC-418® and Tanita BF-689®, respectively. All AUC values for ROC curves were statistically significant and there were no differences between AUC values measured by both BIA devices. The BF% values associated with the IOTF-recommended BMI cut-off for overweight/obesity may require age- and sex-specific threshold values in Colombian children and adolescents aged 9–17 years and could be used as a surrogate method to identify individuals at risk of excess adiposity. PMID:27782039

  20. Performance of Two Bioelectrical Impedance Analyses in the Diagnosis of Overweight and Obesity in Children and Adolescents: The FUPRECOL Study

    Directory of Open Access Journals (Sweden)

    Robinson Ramírez-Vélez

    2016-10-01

    Full Text Available This study aimed to determine thresholds for percentage of body fat (BF% corresponding to the cut-off values for overweight/obesity as recommended by the International Obesity Task Force (IOTF, using two bioelectrical impedance analyzers (BIA, and described the likelihood of increased cardiometabolic risk in our cohort defined by the IOTF and BF% status. Participants included 1165 children and adolescents (54.9% girls from Bogotá (Colombia. Body mass index (BMI was calculated from height and weight. BF% of each youth was assessed first using the Tanita BC-418® followed by a Tanita BF-689®. The sensitivity and specificity of both devices and their ability to correctly classify children as overweight/obesity (≥2 standard deviation, as defined by IOTF, was investigated using receiver operating characteristic (ROC by sex and age groups (9–11, 12–14, and 13–17 years old; Area under curve (AUC values were also reported. For girls, the optimal BF% threshold for classifying into overweight/obesity was found to be between 25.2 and 28.5 (AUC = 0.91–0.97 and 23.9 to 26.6 (AUC = 0.90–0.99 for Tanita BC-418® and Tanita BF-689®, respectively. For boys, the optimal threshold was between 16.5 and 21.1 (AUC = 0.93–0.96 and 15.8 to 20.6 (AUC = 0.92–0.94 by Tanita BC-418® and Tanita BF-689®, respectively. All AUC values for ROC curves were statistically significant and there were no differences between AUC values measured by both BIA devices. The BF% values associated with the IOTF-recommended BMI cut-off for overweight/obesity may require age- and sex-specific threshold values in Colombian children and adolescents aged 9–17 years and could be used as a surrogate method to identify individuals at risk of excess adiposity.

  1. Assessment of bioelectrical activity of synergistic muscles during pelvic floor muscles activation in postmenopausal women with and without stress urinary incontinence: a preliminary observational study

    Directory of Open Access Journals (Sweden)

    Ptaszkowski K

    2015-09-01

    Full Text Available Kuba Ptaszkowski,1 Małgorzata Paprocka-Borowicz,2 Lucyna Słupska,2 Janusz Bartnicki,1,3 Robert Dymarek,4 Joanna Rosińczuk,4 Jerzy Heimrath,5 Janusz Dembowski,6 Romuald Zdrojowy6 1Department of Obstetrics, 2Department of Clinical Biomechanics and Physiotherapy in Motor System Disorders, Wroclaw Medical University, Wroclaw, Poland; 3Department of Obstetrics and Gynecology, Health Center Bitterfeld/Wolfen gGmbH, Bitterfeld-Wolfen, Germany; 4Department of Nervous System Diseases, 5Department of Gynaecology and Obstetrics, Faculty of Health Science, 6Department and Clinic of Urology, Faculty of Postgraduate Medical Training, Wroclaw Medical University, Wroclaw, Poland Objective: Muscles such as adductor magnus (AM, gluteus maximus (GM, rectus abdominis (RA, and abdominal external and internal oblique muscles are considered to play an important role in the treatment of stress urinary incontinence (SUI, and the relationship between contraction of these muscles and pelvic floor muscles (PFM has been established in previous studies. Synergistic muscle activation intensifies a woman’s ability to contract the PFM. In some cases, even for continent women, it is not possible to fully contract their PFM without involving the synergistic muscles. The primary aim of this study was to assess the surface electromyographic activity of synergistic muscles to PFM (SPFM during resting and functional PFM activation in postmenopausal women with and without SUI.Materials and methods: This study was a preliminary, prospective, cross-sectional observational study and included volunteers and patients who visited the Department and Clinic of Urology, University Hospital in Wroclaw, Poland. Forty-two patients participated in the study and were screened for eligibility criteria. Thirty participants satisfied the criteria and were categorized into two groups: women with SUI (n=16 and continent women (n=14. The bioelectrical activity of PFM and SPFM (AM, RA, GM was

  2. Nutritional status and body composition by bioelectrical impedance vector analysis: A cross sectional study in mild cognitive impairment and Alzheimer’s disease

    Science.gov (United States)

    Pomati, Simone; Maggiore, Laura; Forcella, Marica; Cucumo, Valentina; Ghiretti, Roberta; Grande, Giulia; Muzio, Fulvio; Mariani, Claudio

    2017-01-01

    Aims Analysis of nutritional status and body composition in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). Methods A cross-sectional study was performed in a University-Hospital setting, recruiting 59 patients with AD, 34 subjects with MCI and 58 elderly healthy controls (HC). Nutritional status was assessed by anthropometric parameters (body mass index; calf, upper arm and waist circumferences), Mini Nutritional Assessment (MNA) and body composition by bioelectrical impedance vector analysis (BIVA). Variables were analyzed by analysis of variance and subjects were grouped by cognitive status and gender. Results Sociodemographic variables did not differ among the three groups (AD, MCI and HC), except for females’ age, which was therefore used as covariate in a general linear multivariate model. MNA score was significantly lower in AD patients than in HC; MCI subjects achieved intermediate scores. AD patients (both sexes) had significantly (p<0.05) higher height-normalized impedance values and lower phase angles (body cell mass) compared with HC; a higher ratio of impedance to height was found in men with MCI with respect to HC. With BIVA method, MCI subjects showed a significant displacement on the RXc graph on the right side indicating lower soft tissues (Hotelling’s T2 test: men = 10.6; women = 7.9;p < 0,05) just like AD patients (Hotelling’s T2 test: men = 18.2; women = 16.9; p<0,001). Conclusion Bioelectrical parameters significantly differ from MCI and AD to HC; MCI showed an intermediate pattern between AD and HC. Longitudinal studies are required to investigate if BIVA could reflect early AD-changes in body composition in subjects with MCI. PMID:28187148

  3. Bioelectrical Impedance法による体組成の推定 : インピーダンス−体水分量(BI-TBW)法と皮下脂肪厚法から推定された日本人女性の%Fatの比較

    OpenAIRE

    小宮, 秀一; 今井, 克巳; 増田, 卓二; 赤崎, 房生

    1990-01-01

    This article reports a study in which the percent of fat estimated from bioelectrical impedance-total body water measurement and skinfold-body density method in Japanese women were compared. The bioelectrical impedance measurement provides a new approach to assessment of human body composition that is based on the principle that the electrical conductivity of lean body mass, which includes the protein matrix of adipose tissue, contains virtually all the water and conducting electrolytes in th...

  4. Recording of cochlear bioelectricities from facial nerve canal in rats%经大鼠面神经管引导耳蜗生物电反应

    Institute of Scientific and Technical Information of China (English)

    于进涛; 丁大连; 孙虹; Richard Salvi

    2014-01-01

    耳蜗生物电包括耳蜗内淋巴直流电位(EP),耳蜗微音器电位(CM),总和电位(SP),及听神经复合动作电位(CAP),这些不同的电位成份分别起源于耳蜗内不同的组织器官。除了EP是反映血管纹功能状态的静息电位之外,其它耳蜗生物电位都是声刺激诱发的耳蜗内不同组织细胞的电反应。因此,记录耳蜗生物电是直接反映耳蜗功能的最佳观察指标。许多传统的耳蜗生物电引导方法由于把电极置放到中耳腔内难免损伤中耳组织和结构而大都仅适用于急性或亚急性动物实验却不利于开展慢性实验的长期记录和观察。尤其在大鼠目前还缺少一种稳定可靠的长时期观察耳蜗生物电的引导方法。本实验将银丝电极经大鼠茎乳孔插入到面神经管水平段,由于面神经管水平段与耳蜗仅以很薄的骨壁相隔,因此可以从近距离引导出良好的耳蜗生物电反应。同时,由于电极埋藏在面神经管内而无需打开中耳腔,因此也避免了中耳粘膜或听骨链损伤以及因此而可能发生的术后中耳感染。我们在电极植入到同一动物测试耳面神经管水平段后不同时间测试的CAP和CM以及SP波形清晰并具有可靠的重复性,但是在不同动物之间的耳蜗生物电振幅却存在一定的差异,提示本方法引导的耳蜗生物电更适合于对同一测试耳进行实验前后的比较和观察。经面神经管这一天然骨性管道把引导耳蜗生物电的电极巧妙地植入到耳蜗隔壁,为更有效直接观察耳蜗各个组织器官对声刺激的反应提供了有益的参考经验。本文还就各种耳蜗生物电反应的特点及其相互内在联系以及与ABR之间的关系展开了讨论。%Cochlear bioelectric activities, including endocochlear potential (EP), cochlear microphonics (CM), summat-ing potential (SP) and compound action potential (CAP) originate from

  5. Self-sustaining, solar-driven bioelectricity generation in micro-sized microbial fuel cell using co-culture of heterotrophic and photosynthetic bacteria

    Science.gov (United States)

    Liu, Lin; Choi, Seokheun

    2017-04-01

    Among many energy harvesting techniques with great potential, microbial fuel cell (MFC) technology is arguably the most underdeveloped. Even so, excitement is building, as microorganisms can harvest electrical power from any biodegradable organic source (e.g. wastewater) that is readily available in resource-limited settings. Nevertheless, the requirement for endless introduction of organic matter imposes a limiting factor to this technology, demanding an active feeding system and additional power. Here, we demonstrated self-sustaining bioelectricity generation from a microliter-scale microbial fuel cell (MFC) by using the syntrophic interaction between heterotrophic exoelectrogenic bacteria and phototrophs. The MFC continuously generated light-responsive electricity from the heterotrophic bacterial metabolic respiration with the organic substrates produced by photosynthetic bacteria. Without additional organic fuel, the mixed culture in a 90-μL-chamber MFC generated self-sustained current for more than 13 days, while the heterotrophic culture produced current that decreased dramatically within a few hours. The current from the mixed culture was about 70 times greater than that of the device with only photosynthetic bacteria. The miniaturization provided a short start-up time, a well-controlled environment, and small internal resistance. Those advantages will become the general design platform for micropower generation.

  6. Developing a quantitative measurement system for assessing heterotopic ossification and monitoring the bioelectric metrics from electrically induced osseointegration in the residual limb of service members.

    Science.gov (United States)

    Isaacson, Brad M; Stinstra, Jeroen G; MacLeod, Rob S; Pasquina, Paul F; Bloebaum, Roy D

    2010-09-01

    Poor prosthetic fit is often the result of heterotopic ossification (HO), a frequent problem following blast injuries for returning service members. Osseointegration technology offers an advantage for individuals with significant HO and poor socket tolerance by using direct skeletal attachment of a prosthesis to the distal residual limb, but remains limited due to prolonged post-operative rehabilitation regimens. Therefore, electrical stimulation has been proposed as a catalyst for expediting skeletal attachment and the bioelectric effects of HO were evaluated using finite element analysis in 11 servicemen with transfemoral amputations. Retrospective computed tomography (CT) scans provided accurate reconstructions, and volume conductor models demonstrated the variability in residual limb anatomy and necessity for patient-specific modeling to characterize electrical field variance if patients were to undergo a theoretical osseointegration of a prosthesis. In this investigation, the volume of HO was statistically significant when selecting the optimal potential difference for enhanced skeletal fixation, since higher HO volumes required increased voltages at the periprosthetic bone (p = 0.024, r = 0.670). Results from Spearman's rho correlations also indicated that the age of the subject and volume of HO were statistically significant and inversely proportional, in which younger service members had a higher frequency of HO (p = 0.041, r = -0.622). This study demonstrates that the volume of HO and age may affect the voltage threshold necessary to improve current osseointegration procedures.

  7. A STUDY ON BIOELECTRICITY PRODUCTION BY THE SYNERGISTIC ACTION OF BACILLUS TEQUILENSIS DMR-5 AND PSEUDOMONAS AERUGINOSA DMR-3 ISOLATED FROM RUMEN FLUID

    Directory of Open Access Journals (Sweden)

    Jothinathan Deepika

    2013-01-01

    Full Text Available The present study focuses on the bioelectricity production from pure culture of Bacillus tequilensis DMR-5 and Pseudomonas aeruginosa DMR-3. Both the cultures were isolated from the anodic biofilm of pre-run MFC’s with rumen fluid as anodic substance. They were checked for the power production for 10 days both as pure isolates and co-culture. Bacillus tequilensis and Pseudomonas aeruginosa produced 250 mV and 20 mA, 310 mV and 10 mA respectively. Both these bacteria when used as mixed culture (110×105CFU/mL produced 450 mV and 40 mA. The biofilm of the anode was taken for cyclic voltammetry study and the oxidation and reduction peaks observed in both forward and reverse scan confirmed the electrochemical nature of the bacteria. Based on the power readings measured and cyclic voltammograms obtained, it has been found that the co-culture produced more power than the pure cultures when used individually in the Microbial fuel cell.

  8. Treatment of colour industry wastewaters with concomitant bioelectricity production in a sequential stacked mono-chamber microbial fuel cells-aerobic system.

    Science.gov (United States)

    Fernando, Eustace; Keshavarz, Taj; Kyazze, Godfrey; Fonseka, Keerthi

    2016-01-01

    The scalability of any microbial fuel cell (MFC)-based system is of vital importance if it is to be utilized for potential field applications. In this study, an integrated MFC-aerobic bioreactor system was investigated for its scalability with the purpose of treating a simulated dye wastewater and industrial wastewaters originated from textile dyebaths and leather tanning. The influent containing real wastewater was fed into the reactor in continuous mode at ambient temperature. Three MFC units were integrated to act in unison as a single module for wastewater treatment and a continuously stirred aerobic bioreactor operating downstream to the MFC module was installed in order to ensure more complete degradation of colouring agents found in the wastewater. Total colour removal in the final effluent exceeded 90% in all experiments where both synthetic (AO-7 containing) and real wastewater were used as the influent feed. The chemical oxygen demand reduction also exceeded 80% in all experiments under the same conditions. The MFC modules connected in parallel configuration allowed obtaining higher current densities than that can be obtained from a single MFC unit. The maximum current density of the MFC stack reached 1150 mA m(-2) when connected in a parallel configuration. The outcome of this work implies that suitably up-scaled MFC-aerobic integrated bioprocesses could be used for colour industry wastewater treatment under industrially relevant conditions with possible prospects of bioelectricity generation.

  9. Single chamber microbial fuel cell (SCMFC) with a cathodic microalgal biofilm: A preliminary assessment of the generation of bioelectricity and biodegradation of real dye textile wastewater.

    Science.gov (United States)

    Logroño, Washington; Pérez, Mario; Urquizo, Gladys; Kadier, Abudukeremu; Echeverría, Magdy; Recalde, Celso; Rákhely, Gábor

    2017-06-01

    An air exposed single-chamber microbial fuel cell (SCMFC) using microalgal biocathodes was designed. The reactors were tested for the simultaneous biodegradation of real dye textile wastewater (RTW) and the generation of bioelectricity. The results of digital image processing revealed a maximum coverage area on the biocathodes by microalgal cells of 42%. The atmospheric and diffused CO2 could enable good algal growth and its immobilized operation on the cathode electrode. The biocathode-SCMFCs outperformed an open circuit voltage (OCV), which was 18%-43% higher than the control. Furthermore, the maximum volumetric power density achieved was 123.2 ± 27.5 mW m(-3). The system was suitable for the treatment of RTW and the removal/decrease of COD, colour and heavy metals. High removal efficiencies were observed in the SCMFCs for Zn (98%) and COD (92-98%), but the removal efficiencies were considerably lower for Cr (54-80%). We observed that this single chamber MFC simplifies a double chamber system. The bioelectrochemical performance was relatively low, but the treatment capacity of the system seems encouraging in contrast to previous studies. A proof-of-concept experiment demonstrated that the microalgal biocathode could operate in air exposed conditions, seems to be a promising alternative to a Pt cathode and is an efficient and cost-effective approach to improve the performance of single chamber MFCs.

  10. BODY COMPOSITION OF YOUNG PEOPLE AGED 17-18 YEARS, PRACTICING AND NOT PRACTICING SWIMMING, WITH THE USE OF THE BIOELECTRICAL IMPEDANCE METHOD

    Directory of Open Access Journals (Sweden)

    Jendrysek Marek

    2015-11-01

    Full Text Available Purpose: Body composition evaluation of youth aged 17-18 of a different physical activity with the help of bioelectric impedance method. Material and Methods: 18 boys practicing swimming and 19 boys not practicing it took part in the study, making up a control group. Height, weight, BMI, lean body mass, the content of fat and water, Rohr factor were evaluated. Non-parametric Mann-Whitney test has been used to evaluate the differences in the range of the tissue components between the two groups. Results: Statistically significant differences were found on the p<0,05 level in % fat content. Mean body weight in experimental group was 71.5 kg, while in control group it was 69.4 kg. Minimum and maximum weight in group of swimming-practicing persons was: 56.6-92.2 kg. Increased body weight in the group of swimmers can result from greater amount of active tissue in this group compared with persons of low physical activity. Proportionally, it amounted to 64.3 kg and 61.3 kg. In the tested groups, minimal and maximal values of amount of active tissue proportionately amounted to: 54.1-78 and 49.5-72,3 kg. Conclusions: Physical activity modifies body composition. Active lifestyle is one of the methods for prevention of overweight and obesity.

  11. 基于FPGA的生物电阻抗成像系统设计%Design of bioelectrical electrical impedance tomography system based on FPGA

    Institute of Scientific and Technical Information of China (English)

    丁忠林; 陈晓艳; 吴佳妮

    2012-01-01

    According to requirements of electrical impedance tomography, the 16 electrode bioelectrical electrical impedance system was designed in this paper, which embedded 8 bits microprocessor PicoBlaze to realize logic control for generating excitation signals and high-speed A/D acquisition, realization of digital demodulation and the data was be transferred to PC through RS232, redraw the human body resistivity distribution or change images .The system provides a very good hardware design scheme for widely research of electrical impedance tomography.%根据电阻抗断层成像技术要求,设计了以Spartan3E系列XC3S500E FPGA为核心的16电极生物电阻抗成像系统,系统嵌入8 bit微处理器PicoBlaze实现逻辑控制并产生激励信号实现高速A/D采集及实现数字解调,通过RS232将采集数据传输到PC机,重建人体内部的电阻率分布或其变化图像.为广泛应用研究电阻抗断层成像技术提供一种硬件设计方案.

  12. The effect of algae species on the bioelectricity and biodiesel generation through open-air cathode microbial fuel cell with kitchen waste anaerobically digested effluent as substrate.

    Science.gov (United States)

    Hou, Qingjie; Nie, Changliang; Pei, Haiyan; Hu, Wenrong; Jiang, Liqun; Yang, Zhigang

    2016-10-01

    Five strains algae (Golenkinia sp. SDEC-16, Chlorella vulgaris, Selenastrum capricornutum, Scenedesmus SDEC-8 and Scenedesmus SDEC-13) were screened as an effective way to promote recover electricity from MFC for kitchen waste anaerobically digested effluent (KWADE) treatment. The highest OCV, power density, biomass concentration and total lipid content were obtained with Golenkinia sp. SDEC-16 as the co-inoculum, which were 170mV, 6255mWm(-3), 325mgL(-1) and 38%, respectively. Characteristics of the organics in KWADE were analyzed, and the result showed that the hydrophilic and acidic fractions were more readily degraded, compared to the neutral fractions during the operation. Maximum COD and TN removal efficiency were 43.59% and 37.39% when inoculated with Golenkinia sp. SDEC-16, which were roughly 3.22 and 3.04 times higher than that of S. capricornutum. This study demonstrated that Golenkinia sp. SDEC-16 was a promising species for bioelectricity generation, lipid production and KWADE treatment.

  13. Wearable Multi-Frequency and Multi-Segment Bioelectrical Impedance Spectroscopy for Unobtrusively Tracking Body Fluid Shifts during Physical Activity in Real-Field Applications: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Federica Villa

    2016-05-01

    Full Text Available Bioelectrical Impedance Spectroscopy (BIS allows assessing the composition of body districts noninvasively and quickly, potentially providing important physiological/clinical information. However, neither portable commercial instruments nor more advanced wearable prototypes simultaneously satisfy the demanding needs of unobtrusively tracking body fluid shifts in different segments simultaneously, over a broad frequency range, for long periods and with high measurements rate. These needs are often required to evaluate exercise tests in sports or rehabilitation medicine, or to assess gravitational stresses in aerospace medicine. Therefore, the aim of this work is to present a new wearable prototype for monitoring multi-segment and multi-frequency BIS unobtrusively over long periods. Our prototype guarantees low weight, small size and low power consumption. An analog board with current-injecting and voltage-sensing electrodes across three body segments interfaces a digital board that generates square-wave current stimuli and computes impedance at 10 frequencies from 1 to 796 kHz. To evaluate the information derivable from our device, we monitored the BIS of three body segments in a volunteer before, during and after physical exercise and postural shift. We show that it can describe the dynamics of exercise-induced changes and the effect of a sit-to-stand maneuver in active and inactive muscular districts separately and simultaneously.

  14. 多频多段人体生物电阻抗测量系统%A Bioelectrical Impedance Measurement System Based on Multi-Frequency and Multi-Segment Technology

    Institute of Scientific and Technical Information of China (English)

    高秀娥; 唐佳; 陈波

    2012-01-01

    Bioelectrical impedance is an important composition of human body, and reflects the physical conditions of human tissues to some extent. Based on this, a multi-frequency and multi-segment bioelectrical impedance measurement system is designed on the principle of eight electrodes. In fact, the system, which consists of MCU system, sinusoidal excitation current source, RMS-to-DC circuit and etc, has achieved the impedance measurement of the extremities as well as the trunk under the frequency ranged from 5 ~ 500 kHz. Experiment results show that the system finally realizes high-accuracy measurements of amplitude and phase of bioelectrical impedance with the result of a relative error of magnitude which is less than 0. 7% and an absolute error of phase which is less than 0.8°.%人体生物电阻抗是人体体成分的重要组成部分,在一定程度上反映了人体组织的生理状况.基于此,设计了一套基于八电极的多频多段人体生物电阻抗测量系统.测量系统由单片机系统、正弦交流激励电流源、有效值检测电路等组成,实现了5 ~ 500 kHz频率范围的左右上下肢及躯干的5段测量.测试结果表明,测量系统实现了人体生物电阻抗的幅值和相位的高精度测量,幅值相对误差小于0.7%,相位绝对误差小于0.8°.

  15. A STUDY ON BIOELECTRICITY PRODUCTION BY THE SYNERGISTIC ACTION OF BACILLUS TEQUILENSIS DMR-5 AND PSEUDOMONAS AERUGINOSA DMR-3 ISOLATED FROM RUMEN FLUID

    OpenAIRE

    Jothinathan Deepika; Sundaram Meignanalakshmi; Wilson Richard Thilagaraj

    2013-01-01

    The present study focuses on the bioelectricity production from pure culture of Bacillus tequilensis DMR-5 and Pseudomonas aeruginosa DMR-3. Both the cultures were isolated from the anodic biofilm of pre-run MFCâs with rumen fluid as anodic substance. They were checked for the power production for 10 days both as pure isolates and co-culture. Bacillus tequilensis and Pseudomonas aeruginosa produced 250 mV and 20 mA, 310 mV and 10 mA respectively. Both these bacteria when used as mixed culture...

  16. Bioelectrical impedance phase angle in clinical practice: implications for prognosis in stage IIIB and IV non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Grutsch James F

    2009-01-01

    Full Text Available Abstract Background A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient outcomes. Bioelectrical impedance analysis (BIA is an easy-to-use and non-invasive technique to evaluate changes in body composition and nutritional status. We investigated the prognostic role of BIA-derived phase angle in advanced non-small cell lung cancer (NSCLC. Methods A case series of 165 stages IIIB and IV NSCLC patients treated at our center. The Kaplan Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle, independent of stage at diagnosis and prior treatment history. Results 93 were males and 72 females. 61 had stage IIIB disease at diagnosis while 104 had stage IV. The median phase angle was 5.3 degrees (range = 2.9 – 8. Patients with phase angle 5.3 had 12.4 months (95% CI: 10.5 to 18.7; n = 84; (p = 0.02. After adjusting for age, stage at diagnosis and prior treatment history we found that every one degree increase in phase angle was associated with a relative risk of 0.79 (95% CI: 0.64 to 0.97, P = 0.02. Conclusion We found BIA-derived phase angle to be an independent prognostic indicator in patients with stage IIIB and IV NSCLC. Nutritional interventions targeted at improving phase angle could potentially lead to an improved survival in patients with advanced NSCLC.

  17. EFFECT OF INTERMITTENT SUB-MAXIMAL EXERCISE ON PERCENT BODY FAT USING LEG-TO-LEG BIOELECTRICAL IMPEDANCE ANALYSIS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Joseph L. Andreacci

    2006-09-01

    Full Text Available The purpose of this investigation was to determine the effect of intermittent sub-maximal exercise on percent body fat (%BF estimated by leg-to-leg bioelectrical impedance analysis (LBIA in children. Fifty-nine children (29 girls; 30 boys mean age 9.0 ± 1.3 years participated in this study. LBIA measured %BF values were obtained immediately before and within five minutes after completing an intermittent exercise protocol consisting of three 8-minute sub-maximal exercise bouts (2.74 km·hr-1, 0% grade; 4.03 km·hr-1, 0% grade; and 5.47 km·hr-1, 0% grade each separated by a 5-min seated rest period. The three exercise bouts corresponded to 56%, 61% and 71% of maximal heart rate. Significant differences (p < 0.001 were observed for fat mass, fat free mass, total body water, and body weight, post-exercise in both groups. Significant reductions (p < 0.001 in %BF were observed post-exercise in the female (23.1 ± 9.9 vs. 21.8 ± 9. 9 % and male (23.3 ± 10.5 vs. 21.8 ± 10.2 % children when compared to pre-exercise values. However, for the majority of the subjects (females = 86%; males = 73% the decrease in %BF post- exercise was less than 2.0 %BF. These data indicate that sub-maximal intermittent exercise, that may be representative of daily free-form activities in children, will most likely have a limited impact on %BF estimates when the assessment is performed immediately post-exercise

  18. A Comparison Study of Portable Foot-to-Foot Bioelectrical Impedance Scale to Measure Body Fat Percentage in Asian Adults and Children

    Directory of Open Access Journals (Sweden)

    Pei Ying Sim

    2014-01-01

    Full Text Available Objective. To compare the measurements of body fat percentage (BF% using the foot-to-foot bioelectrical impedance analysis (FTF-BIA with the direct segmental multifrequency BIA (DSM-BIA. Methods. There were 36 men and 52 women (37.1±14.3 years with 57% Malays, 30% Chinese, and 13% Indian. For children, there were 45 boys and 26 girls (11.5±2.5 years with 52% Malay, 15% Chinese, and 33% Indian. Results. Mean height for men was 168.4 cm, 11 cm taller than women. Men were 10 kg heavier than women at 70 kg. BF% in women was 32% and 33% whereas BF% in men was 23% and 25% when measured using FTF-BIA and DSM-BIA, respectively. In children, BF% measured with FTF-BIA and DSM-BIA was 49% and 46%, respectively. The correlations were significant for men (r=0.92, SEE = 2.80, women (r=0.91, SEE = 3.31, boys (r=0.95, SEE = 5.44, and girls (r=0.96, SEE = 5.27. The BF% in underweight/normal (r=0.92, SEE = 2.47 and that in overweight/obese adults (r=0.89, SEE = 3.61 were strongly correlated. The correlations were significant in normal/underweight (r=0.94, SEE = 3.78 and obese/overweight children (r=0.83, SEE = 6.49. All ethnic groups showed significant correlation with BF%. Malay adults (r=0.92, SEE = 3.27 and children (r=0.94, SEE = 0.88 showed significant mean differences in BF%. Conclusion. The FTF-BIA showed higher accuracy for all normal/underweight and Chinese group with acceptable overestimation in children and underestimation in adults. Caution should be taken when interpreting BF% depending on gender, BMI, and ethnicity.

  19. Prediction of fat-free mass and percentage of body fat in neonates using bioelectrical impedance analysis and anthropometric measures: validation against the PEA POD.

    Science.gov (United States)

    Lingwood, Barbara E; Storm van Leeuwen, Anne-Martine; Carberry, Angela E; Fitzgerald, Erin C; Callaway, Leonie K; Colditz, Paul B; Ward, Leigh C

    2012-05-01

    Accurate assessment of neonatal body composition is essential to studies investigating neonatal nutrition or developmental origins of obesity. Bioelectrical impedance analysis or bioimpedance analysis is inexpensive, non-invasive and portable, and is widely used in adults for the assessment of body composition. There are currently no prediction algorithms using bioimpedance analysis in neonates that have been directly validated against measurements of fat-free mass (FFM). The aim of the study was to evaluate the use of bioimpedance analysis for the estimation of FFM and percentage of body fat over the first 4 months of life in healthy infants born at term, and to compare these with estimations based on anthropometric measurements (weight and length) and with skinfolds. The present study was an observational study in seventy-seven infants. Body fat content of infants was assessed at birth, 6 weeks, 3 and 4·5 months of age by air displacement plethysmography, using the PEA POD body composition system. Bioimpedance analysis was performed at the same time and the data were used to develop and test prediction equations for FFM. The combination of weight+sex+length predicted FFM, with a bias of < 100 g and limits of agreement of 6-13 %. Before 3 months of age, bioimpedance analysis did not improve the prediction of FFM or body fat. At 3 and 4·5 months, the inclusion of impedance in prediction algorithms resulted in small improvements in prediction of FFM, reducing the bias to < 50 g and limits of agreement to < 9 %. Skinfold measurements performed poorly at all ages.

  20. Evaluation of the BOD POD and leg-to-leg bioelectrical impedance analysis for estimating percent body fat in National Collegiate Athletic Association Division III collegiate wrestlers.

    Science.gov (United States)

    Dixon, Curt B; Deitrick, Ronald W; Pierce, Joseph R; Cutrufello, Paul T; Drapeau, Linda L

    2005-02-01

    The purpose of this study was to compare percent body fat (%BF) estimated by air displacement plethysmography (ADP) and leg-to-leg bioelectrical impedance analysis (LBIA) with hydrostatic weighing (HW) in a group (n = 25) of NCAA Division III collegiate wrestlers. Body composition was assessed during the preseason wrestling weight certification program (WCP) using the NCAA approved methods (HW, 3-site skinfold [SF], and ADP) and LBIA, which is currently an unaccepted method of assessment. A urine specific gravity less than 1.020, measured by refractometry, was required before all testing. Each subject had all of the assessments performed on the same day. LBIA measurements (Athletic mode) were determined using a Tanita body fat analyzer (model TBF-300A). Hydrostatic weighing, corrected for residual lung volume, was used as the criterion measurement. The %BF data (mean +/- SD) were LBIA (12.3 +/- 4.6), ADP (13.8 +/- 6.3), SF (14.2 +/- 5.3), and HW (14.5 +/- 6.0). %BF estimated by LBIA was significantly (p < 0.01) smaller than HW and SF. There were no significant differences in body density or %BF estimated by ADP, SF, and HW. All methods showed significant correlations (r = 0.80-0.96; p < 0.01) with HW. The standard errors of estimate (SEE) for %BF were 1.68, 1.87, and 3.60%; pure errors (PE) were 1.88, 1.94, and 4.16% (ADP, SF, and LBIA, respectively). Bland-Atman plots for %BF demonstrated no systematic bias for ADP, SF, and LBIA when compared with HW. These preliminary findings support the use of ADP and SF for estimating %BF during the NCAA WCP in Division III wrestlers. LBIA, which consistently underestimated %BF, is not supported by these data as a valid assessment method for this athletic group.

  1. Indicaxanthin from Opuntia ficus-indica Crosses the Blood-Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts.

    Science.gov (United States)

    Allegra, Mario; Carletti, Fabio; Gambino, Giuditta; Tutone, Marco; Attanzio, Alessandro; Tesoriere, Luisa; Ferraro, Giuseppe; Sardo, Pierangelo; Almerico, Anna Maria; Livrea, Maria Antonia

    2015-08-26

    Indicaxanthin is a bioactive and bioavailable betalain pigment from the Opuntia ficus-indica fruits. In this in vivo study, kinetic measurements showed that indicaxanthin is revealed in the rat brain within 1 h from oral administration of 2 μmol/kg, an amount compatible with a dietary consumption of cactus pear fruits in humans. A peak (20 ± 2.4 ng of indicaxanthin per whole brain) was measured after 2.5 h; thereafter the molecule disappeared with first order kinetics within 4 h. The potential of indicaxanthin to affect neural activities was in vivo investigated by a microiontophoretic approach. Indicaxanthin, administered in a range between 0.085 ng and 0.34 ng per neuron, dose-dependently modulated the rate of discharge of spontaneously active neurons of the hippocampus, with reduction of the discharge and related changes of latency and duration of the effect. Indicaxanthin (0.34 ng/neuron) showed inhibitory effects on glutamate-induced excitation, indicating activity at the level of glutamatergic synapses. A molecular target of indicaxanthin is suggested by in silico molecular modeling of indicaxanthin with N-methyl-D-aspartate receptor (NMDAR), the most represented of the glutamate receptor family in hippocampus. Therefore, at nutritionally compatible amounts indicaxanthin (i) crosses the rat BBB and accumulates in brain; (ii) can affect the bioelectric activity of hippocampal neurons locally treated with amounts comparable with those measured in the brain; and (iii) modulates glutamate-induced neuronal excitation. The potential of dietary indicaxanthin as a natural neuromodulatory agent deserves further mechanistic and neurophysiologic investigation.

  2. Percentage of body fat assessment using bioelectrical impedance analysis and dual-energy X-ray absorptiometry in a weight loss program for obese or overweight Chinese adults.

    Directory of Open Access Journals (Sweden)

    Yi-Chun Li

    Full Text Available The current study aimed to compare the estimates of body fat percentage (%BF by performing bioelectrical impedance analysis (BIA and dual energy X-ray absorptiometry (DXA in a sample of obese or overweight Chinese adults who participated in a weight-loss randomized control trial stratified by gender to determine whether or not BIA is a valid measurement tool. Among 189 adults [73 males, 116 females; age = 41 to 74 years; mean body mass index (BMI = 27.3 kg/m(2], assessments of %BF at the baseline and six months from the baseline were conducted by performing BIA and DXA. Bland-Altman analyses and multiple regression analyses were used to assess the relationships between %BFBIA and %BFDXA. Compared with DXA, BIA underestimated %BF [in males: 4.6, -2.4 to 11.7 (mean biases, 95% limit of agreement at the baseline, 1.4, -7.4 to 10.2 at the endpoint, and 3.2, -4.8 to 11.3 in changes; in females: 5.1, -2.4 to 12.7; 2.2, -6.1 to 10.4; and 3.0, -4.8 to 10.7, respectively]. For males and females, %BFDXA proved to be a significant predictor of the difference between DXA and BIA at the baseline, the endpoint, and in changes when BMI and age were considered (in males: p<0.01 and R (2 = 23.1%, 24.1%, 20.7%, respectively; for females: p<0.001 and R (2 = 40.4%, 48.8%, 25.4%, respectively. The current study suggests that BIA provides a relatively accurate prediction of %BF in individuals with normal weight, overweight, or obesity after the end of weight-loss program, but less accurate prediction of %BF in obese individuals at baseline or weight change during the weight-loss intervention program.

  3. Effect of the ethinylestradiol/norelgestromin contraceptive patch on body composition. Results of bioelectrical impedance analysis in a population of Italian women

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    Bruni Vincenzina

    2008-08-01

    Full Text Available Abstract Background As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag International, Belgium on body composition using bioelectrical impedance analysis (BIA. Methods Body weight and impedance vector components (resistance (R and reactance (Xc, at 50 kHz frequency, Akern-RJL Systems analyzer were recorded before entry, after 1, 3 and 6 months in 182 Italian healthy women aged 29 yr (18 to 45, and with BMI 21.8 kg/m2 (16 to 31. Total body water (TBW was estimated with a BIA regression equation. Vector BIA was performed with the RXc mean graph method and the Hotelling's T2 test for paired and unpaired data. Results After 6 months body weight increased by 0.64 kg (1.1% and TBW increased by 0.51 L (1.7%. The pattern of impedance vector displacement indicated a small increase in soft tissue hydration (interstitial gel fluid. Body composition changes did not significantly differ among groups of previous contraceptive methods. Arterial blood pressure did not significantly change over time. Conclusion After 6 months of treatment with the ethinylestradiol/norelgestromin contraceptive patch we found a minimal, clinically not relevant, increase in body weight less than 1 kg that could be attributed to an adaptive interstitial gel hydration. This fluctuation is physiological as confirmed by the lack of any effect on blood pressure. This could be useful in increasing women's choice, acceptability and compliance of the ethinylestradiol/norelgestromin contraceptive patch.

  4. Effect of intermittent sub-maximal exercise on percent body fat using leg-to-leg bioelectrical impedance analysis in children.

    Science.gov (United States)

    L Andreacci, Joseph; B Dixon, Curt; Ledezma, Christina; L Goss, Fredric

    2006-01-01

    The purpose of this investigation was to determine the effect of intermittent sub-maximal exercise on percent body fat (%BF) estimated by leg-to-leg bioelectrical impedance analysis (LBIA) in children. Fifty-nine children (29 girls; 30 boys) mean age 9.0 ± 1.3 years participated in this study. LBIA measured %BF values were obtained immediately before and within five minutes after completing an intermittent exercise protocol consisting of three 8-minute sub-maximal exercise bouts (2.74 km·hr(-1), 0% grade; 4.03 km·hr(-1), 0% grade; and 5.47 km·hr(-1), 0% grade) each separated by a 5-min seated rest period. The three exercise bouts corresponded to 56%, 61% and 71% of maximal heart rate. Significant differences (p < 0.001) were observed for fat mass, fat free mass, total body water, and body weight, post-exercise in both groups. Significant reductions (p < 0.001) in %BF were observed post-exercise in the female (23.1 ± 9.9 vs. 21.8 ± 9. 9 %) and male (23.3 ± 10.5 vs. 21.8 ± 10.2 %) children when compared to pre-exercise values. However, for the majority of the subjects (females = 86%; males = 73%) the decrease in %BF post- exercise was less than 2.0 %BF. These data indicate that sub-maximal intermittent exercise, that may be representative of daily free-form activities in children, will most likely have a limited impact on %BF estimates when the assessment is performed immediately post-exercise. Key PointsLBIA measures of body weight, percent body fat, fat mass, fat free mass and total body water were significantly lower after the intermittent sub-maximal exercise.The reductions in percent body fat for girls (1.4%) and boys (1.5%) compare favorably to previous investigations.Intermittent exercise, that may be representative of daily free-form activities in children, will most likely have a limited impact on LBIA percent body fat estimates.

  5. Assessment of body fat proportion by means of bioelectrical impedance in athletic boys aged 7 to 18 years with respect to specific types of instruments

    Directory of Open Access Journals (Sweden)

    Sigmund Martin

    2015-07-01

    Full Text Available BACKGROUND: Bioelectrical impedance (BIA seems an appropriate method for basic diagnostics of body composition in a practical environment. This is a non-time consuming non-invasive method that provides a high degree of response relevance. However, the values identifi ed by the BIA method are susceptible to a number of factors, which need to be taken into account during the investigation stage and interpretation of the results. One of the signifi cant factors infl uencing the outcomes of measurement is the instrument factor.OBJECTIVE: The objective of the present comparative survey was to analyse the proportions of body fat by means of the BIA hand-to-leg method and BIA leg-to-leg method in a sample of athletic individuals aged 7 to 18 years.METHODS: The survey included a total of 178 ice-hockey players aged 7 to 18 years. The proportion of body fat analysed by means of the BIA hand-to-leg method was measured by the Tanita BC-418 MA instrument. For the purposes of the BIA leg-to-leg method the Tanita BF-350 instrument was used (Tanita, Japan. Both instruments work at a frequency of 50 kHz.RESULTS: The percentage of body fat established by the BIA leg-to-leg method (M = 13.5%; SD = 4.8 indicated signifi cantly lower values of fat percentage than the values measured by the BIA hand-to-leg method (M = 17.1%; SD = 4.3. The overall diff erence represents an average value of 3.6% (standard mode; p < .001; d = 0.8. Regarding the monitored age categories the observed diff erences are in the range of 3.1–4.7% (p < .001; d = 0.7–1.2.CONCLUSION: The present study compares the proportions of body fat by means of the BIA leg-to-leg method and BIA hand-to-leg method in athletic boys aged 7 to 18 years. The results measured by the BIA leg-to-leg method signifi cantly undervalue the proportion of body fat in comparison with the BIA hand-to-leg method. The instrument factor and age factor represented signifi - cant variables infl uencing the results of the

  6. 生物电阻抗铜片电极的化学刻蚀工艺%Chemical etching process of copper electrode for bioelectrical impedance technology

    Institute of Scientific and Technical Information of China (English)

    周伟; 宋嵘; 蒋乐伦; 许文平; 梁国开; 程德才; 刘灵蛟

    2012-01-01

    为获得具有强稳定性能的生物电阻抗电极,采用化学刻蚀加工方法,制造出表面具有一系列微结构的金属铜片电极.通过改变加工工艺参数的方法,着重分析刻蚀时间、刻蚀温度、刻蚀液体浓度、样品尺寸等刻蚀工艺参数对铜片电极的蚀刻速率和表面微结构的影响.结果表明:刻蚀速率将随着刻蚀时间的延长而逐渐降低,随着刻蚀温度的升高而逐渐升高,而刻蚀样本尺寸对刻蚀速率的影响不大.选用合适的刻蚀液体浓度(组分3),在室温条件下刻蚀20 min,可以获得具有丰富表面微结构的铜片电极.另外,进行24 h电极对接的连续性交流阻抗测试,与心电电极相比,利用化学刻蚀加工的铜片电极,由于表面具有丰富的表面微结构,可以形成可靠的表面接触,从而具有稳定的交流阻抗值.%In order to obtain bioelectrical impedance electrodes with high stability,the chemical etching process was used to fabricate the copper electrode with a series of surface microstructures.By changing the etching processing parameters,some comparison experiments were performed to reveal the influence of etching time,etching temperature,etching liquid concentration,and sample sizes on the etching rate and surface microstructures of copper electrode.The result shows that the etching rate is decreased with increasing etching time,and is increased with increasing etching temperature.Moreover,it is found that the sample size has little influence on the etching rate.After choosing the reasonable etching liquid composition (formulation 3),the copper electrode with many surface microstructures can be obtained by chemical etching process at room temperature for 20 min.In addition,using the alternating current impedance test of electrode-electrode for 24 h,the copper electrode with a series of surface microstructures fabricated by the etching process presents a more stable impedance value compared with the

  7. [Saarland Growth Study: analyses of body composition of children, aged 3 to 11 years. Measurement of height, weight, girth (abdomen, upper arm, calf) and skinfolds (triceps, biceps, subscapular,suprailiacal, abdominal) and bioelectric impedance (BIA)].

    Science.gov (United States)

    Weinand, C; Müller, S; Zabransky, S; Danker-Hopfe, H

    2000-01-01

    This study aimed to set up current reference charts of anthropometric data in the Saarland. Only national and international data were available to be compared but no former Saarland charts could be found. In the period between 1994 and 1995 we investigated children of 3 to 11 years in a cross-sectional study. Therefore we measured body height, weight, circumferences, skinfolds and bioelectrical impedance (BIA). No significant gender differences were found for body height and weight. Boys of all groups of age showed bigger abdominal circumferences than girls of the same age. On the other hand upper-arm and calf-girth of younger girls were larger than that from boys. In higher age groups circumferences become rather equal. The skinfolds of Saarland girls are thicker than those of boys. The urban rural comparison indicated no significant differences. Nor was any social divergence found among the aforementioned parameters. Regarding height Saarland children are seen to be similar or somewhat shorter than those examined in national or international studies. By the way, in higher percentiles the children in our study were heavier. Thus high BMI values of our study are bigger compared with former studies. According to the definition of obesity by the ECOG almost 20 to 30% of our children are obese. The older children become the higher is the percentage of obesity. Comparing girls and boys, bioelectrical impedance shows higher values for girls. In higher age classes resistance levels gets smaller, in boys more so than in girls. Body fat estimated by a formula based on BIA test parameters yielded negative values. So we propose the use of sex- and age-specific raw charts of BIA test parameters.

  8. Study of cystatin C (Cys C in relation to the calculation of the glomerular filtration rate and bioelectrical impedance analysis parameters in obese patients with and without type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Mario Liani

    2012-01-01

    Full Text Available IntroductionAssessment of renal function based on quantification of the glomerular filtration rate (GFR is essential for early detection of damage and progression of renal diseases. The purpose of our study was to determine the value of cystatin C (Cys C assays in the calculation of the GFR and bioelectrical impedance analysis parameters in obese subjects aged 30-70 years with moderately damaged renal function.Materials and methodsCys C levels were measured with a new immunoturbidimetric kit (Roche Diagnostics and an automated Cobas c6000 analyzer. In the GFR calculation, creatinine and Cys C levels were included. The GFR calculated with the equation that included Cys C in obese and normal-weight patients is not affected by changes in the lean body mass.ResultsObese patients (N = 70 had a mean (± SD serum creatinine level of 1.52 ± 1.0 mg/dL and a mean Cys C level of 1.28 ± 0.59 mg/L. In this group, the GFR calculated on the basis of MDRD, Cys C, and creatinine clearance values showed similar filtered values between MDRD and Cys C and a DS value smaller in the case of Cys C. The correlation (R2 between GFR and its metabolite is higher in the case of Cys C when somatotype parameters (measured with bioelectrical impedance analysis were introduced into the equation.ConclusionsWhen Cys C is included in calculations of GFR, the result shows a higher correlation degree compared to the MDRD system. Given that Cys C shows less intra-individual variability than creatinine, it can be applied in routine diagnostics in a larger number of patients.

  9. 航行及服药前后胃肠电变化分析%Changes of gastrointestinal bioelectricity after taken the medicine in sailing state

    Institute of Scientific and Technical Information of China (English)

    吕礁; 李永平; 施云星; 王石; 周国中; 曾晓虹; 刘长云; 覃林花; 季兴英; 郝杰

    2008-01-01

    目的 观察运动前后及服药后消化道症状及胃肠电各参数变化情况,为寻找相应的防治措施提供理论依据.方法 健康志愿者22名(男21名,女1名),测试前3 d停服各种胃肠动力药.将烧心、反酸、反食及胸骨后疼痛等症状程度和频度的积分(Sc)作为症状指标,同时用WCDF-4b胃肠电分析记录仪,测定航行前、航行中及口服西沙比利2 h后的Sc积分(最高24分),以及主频率(Fp)、频率不稳定系数(FIC)、主功率不稳定系数(DPIC)、主频率不稳定系数(DFIC)、幅度不稳定系数(VIC)等的变化.结果 (1)航行前与航行中相比、航行中与服药后相比,Sc差异均有统计学意义(分别为t=7.8636、3.0849,均为P<0.05).(2)航行中,DPIC、DFIC、VIC均高于航行前(分别为t=3.2424、2.5325、2.4743,均为P<0.05),服药后DFIC则低于航行中(t=2.3930,P<0.05).结论 人体处于大风浪中航行时,消化道症状不仅明显多于航行前,而且其胃肠电分析中各不稳定系数明显升高,胃肠节律出现紊乱,胃食管运动功能发生障碍,出现较多的消化道症状,故有必要用药物加以干预.根据这些参数的变化有助于寻找到更加理想的抗运动病药物.%Objective To observe the changes of alimentary tract symptom and gastrointestinal bioelectricity before and after motion as well as after taken the medicine in sailing state to provide theory bases on prevention and cure measure for motion sickness. Methods Healthy volunteer was 22 cases, among whom there was one female. They stopped taking gastrointestinal dynamia drug three days before test. The integration (Sc) of degree and frequency of some symptoms including heartburn, acid reflux, food reflux and abdominal discomfort was regarded as test index. The following indexes were examined by WCDF-4b electrogastroentero analysis instrument : the Sc of before sailing, during sailing and two hour after taken the medicine as. well as master frequency ( Fp

  10. Are ethnic and gender specific equations needed to derive fat free mass from bioelectrical impedance in children of South asian, black african-Caribbean and white European origin? Results of the assessment of body composition in children study.

    Directory of Open Access Journals (Sweden)

    Claire M Nightingale

    Full Text Available BACKGROUND: Bioelectrical impedance analysis (BIA is a potentially valuable method for assessing lean mass and body fat levels in children from different ethnic groups. We examined the need for ethnic- and gender-specific equations for estimating fat free mass (FFM from BIA in children from different ethnic groups and examined their effects on the assessment of ethnic differences in body fat. METHODS: Cross-sectional study of children aged 8-10 years in London Primary schools including 325 South Asians, 250 black African-Caribbeans and 289 white Europeans with measurements of height, weight and arm-leg impedance (Z; Bodystat 1500. Total body water was estimated from deuterium dilution and converted to FFM. Multilevel models were used to derive three types of equation {A: FFM = linear combination(height+weight+Z; B: FFM = linear combination(height(2/Z; C: FFM = linear combination(height(2/Z+weight}. RESULTS: Ethnicity and gender were important predictors of FFM and improved model fit in all equations. The models of best fit were ethnicity and gender specific versions of equation A, followed by equation C; these provided accurate assessments of ethnic differences in FFM and FM. In contrast, the use of generic equations led to underestimation of both the negative South Asian-white European FFM difference and the positive black African-Caribbean-white European FFM difference (by 0.53 kg and by 0.73 kg respectively for equation A. The use of generic equations underestimated the positive South Asian-white European difference in fat mass (FM and overestimated the positive black African-Caribbean-white European difference in FM (by 4.7% and 10.1% respectively for equation A. Consistent results were observed when the equations were applied to a large external data set. CONCLUSIONS: Ethnic- and gender-specific equations for predicting FFM from BIA provide better estimates of ethnic differences in FFM and FM in children, while generic equations

  11. Association of nutrition parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study.

    Science.gov (United States)

    Sánchez-Lara, Karla; Turcott, Jenny G; Juárez, Eva; Guevara, Patricia; Núñez-Valencia, Carolina; Oñate-Ocaña, Luis F; Flores, Diana; Arrieta, Oscar

    2012-01-01

    Early identification and treatment of nutritional deficiencies can lead to improved outcomes in the quality of life (QoL) and survival of patients with nonsmall cell lung cancer (NSCLC). Noninvasive techniques are needed to evaluate changes in body composition as part of determining nutritional status. The aim of the study was to evaluate the association of nutritional parameters in health-related quality of life (HRQL) and survival in patients with advanced NSCLC. Chemotherapy-naïve patients with advanced NSCLC with good performance status Eastern Cooperative Oncology Group (ECOG) 0-2 were included prospectively in the study. We evaluated inflammatory parameters such as C-reactive protein, platelet/lymphocyte index, neutrophil/lymphocyte index, serum interleukin (IL)-6, and tumor necrosis factor-α, and nutritional variables such as body mass index (BMI) and serum albumin levels. Bioelectrical impedance analysis including phase angle was obtained before cisplatin-based chemotherapy was started. HRQL was assessed by application of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ)-C30 and QLQ-LC13 instruments at baseline. Overall survival (OS) was calculated with the Kaplan-Meier method and analyzed with log-rank and Cox proportional hazard models. One hundred nineteen patients were included. Mean BMI was 24.8 ± 4.5 kg/m(2), average weight loss of patients was 8.4%, and median phase angle was 5.8°. Malnutrition measured by subjective global assessment (SGA), weight loss >10%, BMI >20 was associated with lower HRQL scales. Patients with ECOG 2, high content serum IL-6, lower phase angle, and malnutrition parameters showed lower OS; however, after multivariate analysis, only ECOG 2 [Hazard ratio (HR), 2.7; 95% confidence interval (95% CI), 1.5-4.7; P = 0.001], phase angle ≤5.8° (HR = 3.02; 95% CI: 1.2-7.11; P = 0.011), and SGA (HR = 2.7; 95% CI, 1.31-5.5; P = 0.005) were associated with poor survival. Patients

  12. A histochemical study of promoting peripheral nerve regeneration with simulated bioelectrical impulse of phrenic nerve%模拟膈神经生物电刺激促进周围神经再生的实验研究

    Institute of Scientific and Technical Information of China (English)

    夏奕俊; 徐向阳; 崔茂龙; 王成

    2004-01-01

    目的研究膈神经生物电脉冲(bioelectrical impulse of phrenic nerve,BIPN)在周围神经再生过程中的作用.方法取家兔18只,共36根坐骨神经,平均分为3组.A组为模拟膈神经生物电脉冲(BIPN)组.B组为连续方波脉冲刺激组.C组为不作任何刺激对照组.术后4周,取材检测.神经标本比较神经纤维计数、截面积及远端有髓纤维通过率.取胫前肌标本检测肌纤维截面积.结果 A、B、C 3组的神经缝合口远端有髓神经纤维计数分别为1236.9+202、1082.5+214.6和840.6+174.4根.A、B 2组比较,差异有统计学意义(t值3.323、P值<0.01).A、B、C 3组的神经纤维通过率分别为58.5+7.01、53.2+10.4和35.2+7.3%.A、B 2组比较,差异有统计学意义(t值2.221、P值<0.05).A、B、C 3组的神经纤维截面积分别为127.4+7.2、119.1+5.2和118.8+5.5μm2. A、B 2组比较,差异有统计学意义(t值4.398、P值<0.01).A、B、C 3组的肌纤维截面积分别为704.8+108.5、623.3+189.1和580.5+108.3 μm2 .A、B 2组比较,差异有统计学意义(t值2.308、P值<0.05).结论模拟膈神经电脉冲能有效促进周围神经损伤后的神经纤维再生.

  13. Estimativa da gordura corporal através de equipamentos de bioimpedância, dobras cutâneas e pesagem hidrostática Comparison of body fat estimation by bioelectric impedance, skinfold thickness, and underwater weighing

    Directory of Open Access Journals (Sweden)

    Maurício Nunes Rodrigues

    2001-08-01

    Full Text Available A estimativa do percentual de gordura (%G pela bioimpedância (BIA tem como vantagem a simplicidade da medida. Contudo, a confiabilidade da BIA tem sofrido críticas. O objetivo deste estudo foi comparar a estimativa do %G através das técnicas de bioimpedância (RJL-101; Byodinamics A-310, Maltron BF-900 e BF-906, de dobras cutâneas (DC e da pesagem hidrostática (PH. Observaram-se 25 indivíduos, homogeneizados segundo raça (branca, gênero (masculino e idade (18 a 36 anos. Para a medida de BIA foi utilizada a padronização proposta por Lukaski et al. (1985, 1986. Para as DC foram utilizadas as equações de å 3 DC e å 7 DC (Jackson, Pollock, 1978. Os valores de %G e de volume residual para PH foram preditos, respectivamente, pelas equações de Siri (1961 e Goldman e Becklake (1959. A análise estatística compreendeu: a comparação entre os métodos através da ANOVA com medidas repetidas seguida de testes post-hoc de Tukey; b correlação de Pearson (r; e c cálculo do erro padrão de estimativa (SEE das técnicas em relação à PH. Os resultados indicaram que: a as medidas de BIA não diferiram significativamente, entre si, para o %G estimado; b As medidas dos aparelhos A-310 e BF-906 não coincidiram com a PH (p The main advantage of the bioelectric impedance method (BIA in the determination of body fat (%BF is the simplicity of the procedure. However, its accuracy and reliability have been criticized. The purpose of this study was to compare the %BF obtained by BIA (RJL-101; Biodynamics A-310, Maltron BF-900 e BF-906, by skinfold thickness (ST, and by underwater weighing (UW. Twenty-five subjects, divided in homogenous groups according to age (18 to 36 years, sex (men, and race (white participated in the study. BIA measures were taken using the Lukaski et al. standardization (1985,1986. ST was taken by using the equation of 3 and 7 skinfolds (Jackson, Pollock, 1978. The values of %BF and residual volume for the UW were estimated

  14. Estimativa da massa muscular esquelética em mulheres idosas: validade da impedância bioelétrica Validity of bioelectrical impedance analysis for the estimation of skeletal muscle mass in elderly women

    Directory of Open Access Journals (Sweden)

    Cassiano Ricardo Rech

    2010-04-01

    Full Text Available O presente estudo tem como objetivos: a verificar a concordância entre os métodos da impedância bioelétrica (BIA e da absortometria radiológica de dupla energia (DXA para a estimativa da massa muscular esquelética (MME; e b analisar o poder preditivo de variáveis antropométricas e da BIA para a predição da MME em idosas. Foram avaliadas 120 mulheres (60 a 81 anos, residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa corporal e estatura; a resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310, e pela DXA de corpo inteiro (Lunar Prodigy DF + 14319 Radiation e software 7.52.002 DPX-L. A diferença entre os métodos foi verificada pelo teste t pareado, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão linear múltipla, adotando nível de significância de p 0,01. Observou-se que a BIA subestimou em média 0,8kg (IC95%: -3,7; 2,0kg a MME, quando comparada com a DXA. Foi observada alta correlação entre os métodos (r² = 0,75; p The objectives of the present study were: a to determine the agreement between bioelectrical impedance analysis (BIA and dual-energy X-ray absorptiometry (DXA for the estimation of skeletal muscle mass (SMM, and b to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in elderly women. A total of 120 women (60 to 81 years, living in the southern region of Brazil, were studied. Anthropometric variables (body weight and height were measured. Resistance and hydration of fat-free tissues were measured by tetrapolar BIA (Biodynamics, BF-310 and by whole-body DXA (Lunar Prodigy DF + 14319 Radiation and DPX-L software, version 7.52.002. Differences between methods were determined using the paired t-test, analysis of residuals and correlation coefficient. The predictive value of the

  15. 应用生物电阻抗预测方程评价维持性血液透析患者干体质量%Assessment of dry weight among maintenance hemodialysis patients with the application of bioelectrical impedance prediction equation

    Institute of Scientific and Technical Information of China (English)

    杜静; 隋小妮; 赵战云; 邹作君

    2012-01-01

    Object To explore the accuracy of bioelectrical impedance prediction equation in the evaluation of dry weight among maintenance hemodialysis (MHD) patients. Methods Dry weight of 60 MHD patients was estimated using electrical impedance value of 50 KHz frequency measured by bioelectrical impedance analyzer, combined with slope method and new 3-compartment model. Dry weight of these participants was the post-dialysis weight, measured by inferior vena cava diameter (IVCD) method which was deemed as golden standard. Another 90 individuals with matched gender, age, height, body weight and BMI were selected to construct coefficient and compare the human body parameters with MHD patient. Results Pearson correlation coefficient between the evaluated dry weight by slope method and true dry weight was 0.991. Bland-Altman plot showed these two approaches bore poor consistency and the difference between them was far from zero. Pearson correlation coefficient between assessed dry weight by new 3-compartmental model and true dry weight was 0.993. Bland- Airman plot revealed good consistency between the two methods with stable and minor diffidence as their differences fluctuated near zero. Conclusion Different bioelectrical impedance measuring instrument gives rise to the impact on measured data. In this study, the new 3-compartment model predicts the dry weight of MHD patients more accurately.%目的 探讨运用生物电阻抗预测方程评价维持性血液透析(maintenance hemodialysis,MHD)患者干体质量的准确性. 方法 使用多频生物电阻抗分析仪测定60例MHD患者50千赫下电阻抗值,结合斜率法、新三室模型预测MHD患者干体质量.经下腔静脉直径(inferior vena cava diameter,IVCD)等综合评价,认为患者的干体质量即入选患者本次透析后体质量,可用于干体质量准确性评价.另选择性别、年龄、身高,体质量和体质量指数(BMI)相匹配个体87例,用于构建方程系数及与MHD患

  16. Study on the characteristics of simultaneous enhanced decolorization of azo dye and the prospect of bioelectricity generation by using the microbial fuel cells via AQDS%基于AQDS增强的微生物燃料电池同步降解刚果红染料和产电特性研究

    Institute of Scientific and Technical Information of China (English)

    刘铁梅; 王宝娥

    2013-01-01

    通过在微生物燃料电池(MFC)系统中添加氧化还原介体AQDS,探讨了AQDS对MFC同步降解刚果红染料和产电的影响.结果表明,与空白相比,添加0.005 mmol/L AQDS后,MFC最大功率密度从53.1 mW/m2增大至67 mW/m2,增大了26%;脱色速率从3.3mg/(L·h)增大至16.3 mg/(L·h),增大了400%.AQDS浓度增大至0.05 mmol/L时,MFC功率密度增大至100 mW/m2,进一步增大了49%;脱色速率增大至21.5 mg/(L·),进一步增大了32%.AQDS同时加速了电子由共基质(葡萄糖)到阳极和刚果红染料分子的传递,在减小阳极极化的同时加速了刚果红染料的还原脱色.%This paper intends to bring about our study of the characteristic features of simultaneous enhanced decolorization of azo dye and bioelectricity generation in the microbial fuel cell (MFC) by AQDS.As is known,MFC is a kind of promising biotechnology by using the microorganisms as catalysts to decompose organic substances for simultaneously generation of electric power.During simultaneous decolorization of azo dye and bioelectricity generation,the electron recovered from co-substrate,such as glucose,is divided into two sections:one portion is transferred to die azo dye molecule for reductive decolorization,whereas the other portion is transferred to the anodic electrode for electricity generation.Thus,the electronic transfer from thebacteria to azo dye and to anodic electrode is a technical procedure of rate-limitation as well as a promotion.In this paper,we have managed to enhance the decolorized azo dye and bioelectricity generation in the air-cathode single chambered MFC by adding 9,10-anthraquinone-2,6-disulfonic acid disodium salt (AQDS).Controlling the MFC (without addition of AQDS),we can add 0.005 mmol/L AQDS to enhancing the power density from 53.1 mW/m2 to 67 mW/m2 and 400% to raise the decolorization rate of Congo red to 37% from 3.3 mg/(L·h) to 16.3 mg/(L·h).And,in turn,the concentration of AQDS can be pushed up to

  17. INFLUÊNCIA DE DIFERENTES TIPOS DE ELETRODOS SOBRE OS VALORES DA BIOIMPEDÂNCIA CORPORAL E NA ESTIMATIVA DE MASSA MAGRA (MM EM GATOS ADULTOS INFLUENCE OF DIFFERENT TYPES OF ELECTRODES ON THE BIOELECTRICAL IMPEDANCE VALUES AND IN THE ESTIMATION OF LEAN BODY MASS (LBM IN ADULT CATS

    Directory of Open Access Journals (Sweden)

    Thassila Caccia Feragi Cintra

    2010-04-01

    Full Text Available A bioimpedância (BIC é um método que aplica à tecnologia da impedância no estudo da composição corporal pela avaliação da diferença da condutividade elétrica dos tecidos. Os resultados da BIC são expressos pelas medidas primárias de resistência (R e reatância (Xc. Neste experimento, o método foi desenvolvido para verificar a viabilidade do uso de três diferentes tipos de eletrodos sobre a reprodutibilidade dos valores de R e Xc em gatos adultos. As médias de R e Xc com adesivos e agulhas de acupuntura não diferiram entre si (p?0,05, e os menores valores dos coeficientes de variação obtidos com estes eletrodos sinalizaram para uma melhor reprodutibilidade dos resultados quando comparados com os da agulha hipodérmica. Os diferentes tipos de eletrodos não interferiram nos valores da massa magra (MM estimada por equação específica, porém a agulha de acupuntura mostrou ser o eletrodo mais estável e de melhor aplicabilidade. A MM determinada com os diferentes tipos de eletrodos foi superior (p?0,05 à obtida com a absorciometria de raios-x de dupla energia (DEXA, provavelmente decorrente da equação utilizada na sua estimativa.

    PALAVRAS-CHAVES: Composição corporal, felinos, impedância, massa magra.
    The bioelectrical impedance is a method that applies impedance technology in the study of physical composition by evaluation of electrical conductivity difference on each organism tissue. The results of bioelectrical impedance (BIC are expressed by the resistance (R and reactance (Xc primary measures. This study was carried out to verify the viability of the use of three different electrodes on the repeatability of R and Xc values in adult cats. The averages of R and Xc estimated by adhesive and acupuncture needles did not differ from each other (p?0.05 and the smaller values of the variation coefficient acquired with these electrodes signaled for a better reproducibility of the results when compared with

  18. The Clinical Research on Prevention Effects of Uterine Cavity Absorbed Biological Antiblocking Membrane Implantation plus Large Dose Estrogenic Administration plus Imitable Bioelectricity Stimulation Therapy for Uterine CavityAdhesion after TCRA%宫腔粘连分离术后宫腔放置可吸生物防粘连膜+大剂量雌激素+仿生物电疗预防再次粘连的临床研究

    Institute of Scientific and Technical Information of China (English)

    李艳虹; 梁晓斯; 林东红

    2016-01-01

    目的:探讨生物防粘连膜宫腔放置联合大剂量雌激素治疗,再给予仿生物电刺激治疗对宫腔粘连分离术后的再粘连防治的临床疗效。方法:选取2014年2月-2016年2月本院收治的经TCRA成功分离的中、重度宫腔粘连患者48例作为研究对象,随机分为观察组25例和对照组23例。观察组给予防粘连膜宫腔放置联合大剂量雌激素治疗,再给予仿生物电治疗,对照组则给予防粘连膜宫腔放置联合大剂量雌激素治疗,两组均以30 d为1个疗程,共进行3个疗程,B超检查子宫内膜修复程度。结果:治疗2个疗程后,两组子宫内膜均较治疗前增厚,且观察组优于对照组,比较差异均有统计学意义(P<0.05);观察组治疗总有效率为92.00%,明显高于对照组的56.52%,比较差异有统计学意义(P<0.05)。结论:防粘连膜宫腔放置联合大剂量雌激素治疗,再给予仿生物电刺激疗法能够有效防治宫腔粘连分离术后的再粘连。%Objective:To discuss the clinical effects of uterine cavity absorbed biological antiblocking membrane implantation plus large dose estrogenic administration plus imitable bioelectricity stimulation therapy for uterine cavity adhesion after TCRA.Method:From February 2014 to February 2016,48 cases of successfully separated by TCRA middle and severe uterine cavity adhesion in our hospital were selected as the research objects, they were randomly divided into the observation group of 25 cases and the control group of 23 cases.The observation group was given absorbed biological antiblocking membrane implantation plus large dose estrogenic administration plus imitable bioelectricity stimulation therapy,the control group was given absorbed biological antiblocking membrane implantation plus large dose estrogenic administration,two groups were treated with 30 d for 1 treatment course,a total of 3 courses,the degree of endometrial repair was inspected

  19. Grado de acuerdo entre los índices adiposo-musculares obtenidos a partir de medidas antropométricas del brazo, pliegues cutáneos e impedancia bioeléctrica Interchangeability of the fat-to-fat-free mass ratios obtained by arm anthropometric measures, skinfold thickness and bioelectrical impedance

    Directory of Open Access Journals (Sweden)

    V. Martín Moreno

    2003-04-01

    agreement among the fat-to-fat-free mass ratios obtained by arm anthropometric measures (fat-muscle index, FMI, Siri equation for the sum of four skinfold thickness (body fat-muscle index, BFMI Siri and triceps skinfold (BFMItriceps and bioelectrical impedance (BFMI Omron methods. Methods: This is a cross-sectional study. A total of 145 patients were evaluated by anthropometry and bioelectrical impedance (Omron BF 300(, being estimated the agreement through the Intraclass Correlation Coefficient (ICC and Bland-Altman method. The reference method was BFMI Siri. Results: The ICC between BFMI Siri - BFMItriceps were 0,9304 (0,9035; 0,9498, between BFMI Siri - FMI of 0,7726 (0,6846; 0,8361 and between BFMI Siri - BFMI Omron of 0,9114 (0,8771; 0,9361. BFMItriceps (limits of agreement -0,171 to 0,117 show the best agreement according to Bland-Altman analysis with BFMI Siri, followed by BMFI Siri - BFMI Omron (-0,186; 0,178. The agreement limits between FMI and BFMI Siri (-0,2; 0,42, BFMItriceps (-0,26; 0,42 or BFMI Omron (-0,292; 0,504 were beyond of the established cut-off points (-0,2; 0,2. Conclusions: Due to the nature of the statistical agreement BFMItriceps and BFMI Omron are methods interchangeable methods between them and with BFMI Siri. FMI is not interchangeable with BFMI Siri, BFMI Omron or BFMItriceps. These results suggest that FMI cannot estimate properly the body composition. BFMItriceps and BFMI Omron are valid alternative methods to be used instead BFMI Siri in the fat-to-fat-free mass ratio assessment.

  20. 多频生物电阻抗技术评价 COPD 患者营养状况及其与血气分析指标的相关性%Evaluation of Nutritional Status in COPD Patients by Multi - frequency Bioelectrical Impedance and Its Correlation With Blood Gas Indicators

    Institute of Scientific and Technical Information of China (English)

    黄陈; 朱文艺; 徐静; 李利; 樊荣; 李琦; 王建

    2015-01-01

    Objective To examine the body composition of COPD patients by multi - frequency bioelectrical impedance and investigate the relationship between body composition and blood gas indicators in order to provide clinical references for nutritional support for COPD patients. Methods We enrolled 62 patients who was hospitalized and diagnosed with COPD in the Department of Respiratory Medicine of Xinqiao Hospital from January to June in 2011. Multi - frequency bioelectrical impedance was used to detect the patients' physical composition. We collected data of serum total protein,albumin, prealbumin,hemoglobin,lymph cell count,blood gas( PaCO2 ,PaO2 and SpO2 ),HCO -3 ,Cl - ,K + ,Na + ,pH of the subjects at admission. Statistical analysis was conducted on the above indicators. Results The malnutrition rates assessed by ribosomal protein content,body fat content,BMI and MAC were 41. 9% ,17. 7% ,19. 4% and 16. 1% , respectively. According the BMI,the patients with inadequate,normal and excess nutrition were significantly different( P < 0. 05 )in ribosomal TBW,BFM,PBF,FFM,PBFF,protein content and PBP;the subjects with inadequate nutrition were higher(P <0. 05)than those with normal and high nutrition in PBP;the subjects with inadequate nutrition were lower( P < 0. 05)than those with normal and high nutrition in PBF and FFM. TBW,FFM,ribosomal protein,and SMM were negatively correlated with PaO2 ( r = - 0. 311, - 0. 306, - 0. 308, - 0. 306;P < 0. 05),and BMI was negatively correlated with SpO2 ( r =- 0. 304,P < 0. 05). Conclusion COPD patients have high malnutrition rate when assessed by ribosomal protein. FFM is more sensitive than BMI in nutritional evaluation of COPD patients. The increase of FFM in COPD patients may improve hypoxia tolerance.%目的:应用多频生物电阻抗技术分析 COPD 患者人体成分及其与血气分析指标的关系,为 COPD 患者的营养支持提供依据。方法选择2011年1—6月在新桥医院呼吸科住院并诊断为 COPD

  1. A comparison of fat mass and skeletal muscle mass estimation in male ultra-endurance athletes using bioelectrical impedance analysis and different anthropometric methods Comparación de la masa grasa y muscular estimada en atletas varones de ultra-resistencia utilizando la bioimpedancia eléctrica y diferentes métodos antropométricos

    Directory of Open Access Journals (Sweden)

    B. Knechtle

    2011-12-01

    Full Text Available Two hundred and fifty seven male Caucasian ultraendurance athletes were recruited, pre-race, before different swimming, cycling, running and triathlon races. Fat mass and skeletal muscle mass were estimated using bioelectrical impedance analysis (BIA and anthropometric methods in order to investigate whether the use of BIA or anthropometry would be useful under field conditions. Total body fat estimated using BIA was significantly high (P Se reclutaron a 257 hombres caucasianos que eran atletas de alto rendimiento, antes de competir en diferentes pruebas triatlón de natación, ciclismo y carrera. Se estimaron la masa grasa y la masa de músculo esquelético utilizando un análisis de impedancia bioeléctrica (BIA y métodos antropométricos con el fin de investigar si el uso de BIA o de la antropometría sería útil en tales condiciones de campo. La grasa corporal total estimada por BIA fue significativamente mayor en comparación con la antropometría (P < 0,001. Cuando se compararon los resultados entre BIA y antropometría, se encontraron niveles de concordancia bajos a moderados. Estos resultados concuerdan con las diferencias halladas con el análisis Bland-Altman, lo que indica que la ecuación antropométrica de Ball et al. posee el mayor grado de concordancia (desviación = -3,0 ± 5,8 kg con BIA, con Stewart et al. (desviación = -6,4 ± 6,3 kg, Faulkner (desviación = -4,7 ± 5,8 kg y Wilmore-Siri (desviación = -4,8 ± 6,2 kg. La estimación de la masa de músculo esquelético fue significativamente superior con BIAS que con antropometría (P < 0,001. Los resultados de la ICC y del método Bland-Altman muestran que la ecuación antropométrica de Lee et al. (desviación = -5,4 ± 5,3 kg produjo el mayor grado de concordancia. El método combinado de Janssen et al. entre antropometría y BIA mostró el menor grado de concordancia (desviación = -12,5 ± 5,7 kg. Hubo una diferencia estadísticamente significativa entre los resultados

  2. Comparison of bioelectrical impedance with skinfold thickness and X-ray absorptiometry to measure body composition in HIV-infected with lipodistrophy Comparación de impendancia bioeléctrica con grosor de pliegues cutáneos y absorciometría de rayos X para mensurar la composición corporal de personas con VIH con lipodistrofia

    Directory of Open Access Journals (Sweden)

    H. Siqueira Vassimon

    2011-06-01

    Full Text Available Introduction: Human immunodeficiency vírus (HIV-associated lipodystrophy syndrome (LS includes body composition and metabolic alterations. Lack of validated criteria and tools make difficult to evaluate body composition in this group. Objective: The aim of the study was to compare different methods to evaluate body composition between Brazilians HIV subjects with (HIV+LIPO+ or without LS (HIV+LIPO- and healthy subjects (Control. Methods: in a cross-sectional analyses, body composition was measured by bioelectrical impedance analysis (BIA, skinfold thickness (SF and dual-energy x-ray absorptiometry (DXA in 10 subjects from HIV+LIPO+ group; 22 subjects from HIV+LIPO- group and 12 from Control group. Results: There were no differences in age and body mass index (BMI between groups. The fat mass (FM (% estimated by SF did not correlate with DXA in HIV+LIPO+ group (r = 0,46/ p > 0,05 and had fair agreement in both HIV groups (HIV+LIPO+ =0,35/ HIV+ LIPO- = 0,40. BIA had significant correlation in all groups (p Introducción: El síndrome de lipodistrofia (SL asociado al virus de inmunodeficiencia humana (HIV incluye alteraciones en la composición corporal y metabólica. La falta de herramientas adecuadas y criterios válidos dificultan la evaluación de la composición corporal en este grupo. Objetivo: El objetivo del estudio fue comparar distintos métodos para evaluar la composición corporal entre individuos brasileños con HIV que teniam (HIV+LIPO+ o no LS (HIV+LIPO- e individuos sanos (control. Métodos: Estudio transversal en el que fue evaluada la composición corporal por análisis de impedancia bioeléctrica (BIA, pliegues cutáneos (SF y absorciometría de rayos X de doble energía (DXA en un grupo de 10 individuos con HIV+LIPO+, 22 individuos del grupo HIV+ LIPO- y 12 individuos del grupo control. Resultados: No hubo diferencias en la edad e índice de masa corporal (IMC entre grupos. La masa grasa (MG (% estimada por SF no se correlacion

  3. Bioelectric potentials in the soil-plant system

    Science.gov (United States)

    Pozdnyakov, A. I.

    2013-07-01

    A detailed study of the electric potentials in the soil-plant system was performed. It was found that the electric potential depends on the plant species and the soil properties. A theoretical interpretation of the obtained data was given. All the plants, independently from their species and their state, always had a negative electric potential relative to the soil. The electric potential of the herbaceous plants largely depended on the leaf area. In some plants, such as burdock ( Arctium lappa) and hogweed ( Heracleum sosnowskyi), the absolute values of the negative electric potential exceeded 100 mV. The electric potential was clearly differentiated by the plant organs: in the flowers, it was lower than in the leaves; in the leaves, it was usually lower than in the leaf rosettes and stems. The electric potentials displayed seasonal dynamics. As a rule, the higher the soil water content, the lower the electric potential of the plants. However, an inverse relationship was observed for dandelions ( Taraxacum officinale). It can be supposed that the electric potential between the soil and the plant characterizes the vital energy of the plant.

  4. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets

    NARCIS (Netherlands)

    J.T. Fisher (John); S.R. Tyler (Scott); Y. Zhang (Yulong); B.J. Lee (Ben); X. Liu (Xiaoming); X. Sun (Xinying); H. Sui (Hongshu); B. Liang (Bo); M. Luo (Ma); W. Xie (Weiliang); I. Yi (Iasson); W. Zhou (Weili); Y. Song (Yiqing); N. Keiser (Nicholas); K. Wang (Kai); H.R. de Jonge (Hugo); J.F. Engelhardt (John)

    2013-01-01

    textabstractCystic fibrosis (CF) is a life-shortening, recessive, multiorgan genetic disorder caused by the loss of CF transmembrane conductance regulator (CFTR) chloride channel function found in many types of epithelia. Animal models that recapitulate the human disease phenotype are critical to un

  5. Modeling & imaging of bioelectrical activity principles and applications

    CERN Document Server

    He, Bin

    2010-01-01

    Over the past several decades, much progress has been made in understanding the mechanisms of electrical activity in biological tissues and systems, and for developing non-invasive functional imaging technologies to aid clinical diagnosis of dysfunction in the human body. The book will provide full basic coverage of the fundamentals of modeling of electrical activity in various human organs, such as heart and brain. It will include details of bioelectromagnetic measurements and source imaging technologies, as well as biomedical applications. The book will review the latest trends in

  6. Conductive polymer combined silk fiber bundle for bioelectrical signal recording.

    Directory of Open Access Journals (Sweden)

    Shingo Tsukada

    Full Text Available Electrode materials for recording biomedical signals, such as electrocardiography (ECG, electroencephalography (EEG and evoked potentials data, are expected to be soft, hydrophilic and electroconductive to minimize the stress imposed on living tissue, especially during long-term monitoring. We have developed and characterized string-shaped electrodes made from conductive polymer with silk fiber bundles (thread, which offer a new biocompatible stress free interface with living tissue in both wet and dry conditions.An electroconductive polyelectrolyte, poly(3,4-ethylenedioxythiophene-poly(styrenesulfonate (PEDOT-PSS was electrochemically combined with silk thread made from natural Bombyx mori. The polymer composite 280 µm thread exhibited a conductivity of 0.00117 S/cm (which corresponds to a DC resistance of 2.62 Mohm/cm. The addition of glycerol to the PEDOT-PSS silk thread improved the conductivity to 0.102 S/cm (20.6 kohm/cm. The wettability of PEDOT-PSS was controlled with glycerol, which improved its durability in water and washing cycles. The glycerol treated PEDOT-PSS silk thread showed a tensile strength of 1000 cN in both wet and dry states. Without using any electrolytes, pastes or solutions, the thread directly collects electrical signals from living tissue and transmits them through metal cables. ECG, EEG, and sensory evoked potential (SEP signals were recorded from experimental animals by using this thread placed on the skin. PEDOT-PSS silk glycerol composite thread offers a new class of biocompatible electrodes in the field of biomedical and health promotion that does not induce stress in the subjects.

  7. Establishment of muscle mass diagnostic standard of sarcopenia using a bioelectrical impedance analysis and epidemiological investigation of the elderly in Shanghai%上海地区老年人肌少症骨骼肌质量诊断标准建立和流行病学调查

    Institute of Scientific and Technical Information of China (English)

    陈敏; 白慧婧; 王纯; 王彦; 徐丹凤; 谢华; 易青; 李臻; 李茹

    2015-01-01

    目的 应用生物电阻抗法(BIA)建立上海地区老年人肌少症骨骼肌质量诊断标准并开展上海地区老年人肌少症患病率的调查.方法 对40例志愿者(年龄20~77岁)进行BIA和双能X线吸收仪(DEXA)检测,验证BIA测定瘦体组织的可靠性.对219例(年龄20~40岁)健康青年人(男∶女为100∶119)进行BIA检测,获得峰值肌量和老年人肌少症诊断切点.对657例≥60岁医院体检和社区老年人(男∶女为318∶339)进行BIA检测,了解上海地区老年人肌少症患病率.结果 BIA和DEXA检测瘦体组织差异无统计学意义(P=0.307).健康青年人四肢肌肉组织和身高平方的比值(ASM/身高2)男性和女性分别为(7.90±0.62)kg/m2和(6.12±0.44)kg/m2,老年人肌少症诊断标准男性和女性分别为≤6.66 kg/m2和≤5.24 kg/m2.将老年人分为3个年龄段,60~岁、70~岁和≥80岁3个年龄段男性肌少症的患病率分别为14.6%、25.0%和36.0%,女性分别为6.8%、12.6%和27.9%.老年男性整体患病率为23.6%,女性为11.8%.结论 BIA检测人体肌肉组织是可靠的,且随增龄肌少症患病率明显上升,男性高于女性.%Objective To establish diagnostic standard of sarcopenia using bioelectrical impedance analysis (BIA) and to obtain the prevalence of sarcopenia in the elderly in Shanghai.Methods 40 volunteers aged 20-77 years were enrolled and received BIA and dual-energy X-ray absorptiometry (DEXA) measurements in order to verify the reliability of BIA for measuring lean mass.219 healthy young volunteers aged 20 to 40 years with ratio of gender men:women 100:119 had BIA measurements to obtain peak muscle mass and sarcopenia diagnostic cut-off point of the elderly.657 elderly aged ≥ 60 years with ratio of gendermen:women 318:339 took BIA measurements to obtain the prevalence of sarcopenia in the elderly in Shanghai.Results No statistical difference between BIA-measured and DEXA-measured LM was observed (P =0.307).The

  8. Simultaneous production of bioelectricity and treatment of membrane concentrate in multitube microbial fuel cell.

    Science.gov (United States)

    Koroglu, Emre Oguz; Cetinkaya, Afsin Y; Ozkaya, Bestami; Demir, Ahmet

    2016-11-01

    The performance of upflow multitube microbial fuel cell (UM(2)FC) from membrane concentrate of domestic wastewater (50% concentrate or a volume to concentration ratio of 2) has been investigated in a laboratory test. The test found that the UM(2)FC with the tin-coated copper mesh and coil spring under different hydraulic retention times (HRTs) produced maximum electricity of 916 ± 200 mW/m(3) (61 mW/m(2)) at an HRT of 0.75 day with a 78% soluble chemical oxygen demand (sCOD) removal efficiency and 3% and 20% Coulombic efficiencies (CEs). The whole-cell resistance as calculated from the Nyquist plot and equivalent circuit were approximately 134 and 255 Ω for HRTs of 0.5 and 0.75 days, respectively. Considering HRT, the current increase with longer HRT could be due to longer contact time between organic material and biofilm, which results in a higher electrical efficiency. The results showed that UM(2)FC could represent an effective system for simultaneous membrane concentrate treatment and electricity production after further improvements on MFC and operating conditions.

  9. Location of Bioelectricity Plants in the Madrid Community Based on Triticale Crop: A Multicriteria Methodology

    Directory of Open Access Journals (Sweden)

    L. Romero

    2015-01-01

    Full Text Available This paper presents a work whose objective is, first, to quantify the potential of the triticale biomass existing in each of the agricultural regions in the Madrid Community through a crop simulation model based on regression techniques and multiple correlation. Second, a methodology for defining which area has the best conditions for the installation of electricity plants from biomass has been described and applied. The study used a methodology based on compromise programming in a discrete multicriteria decision method (MDM context. To make a ranking, the following criteria were taken into account: biomass potential, electric power infrastructure, road networks, protected spaces, and urban nuclei surfaces. The results indicate that, in the case of the Madrid Community, the Campiña region is the most suitable for setting up plants powered by biomass. A minimum of 17,339.9 tons of triticale will be needed to satisfy the requirements of a 2.2 MW power plant. The minimum range of action for obtaining the biomass necessary in Campiña region would be 6.6 km around the municipality of Algete, based on Geographic Information Systems. The total biomass which could be made available in considering this range in this region would be 18,430.68 t.

  10. Conversion of Wastes into Bioelectricity and Chemicals by Using Microbial Electrochemical Technologies

    KAUST Repository

    Logan, B. E.

    2012-08-09

    Waste biomass is a cheap and relatively abundant source of electrons for microbes capable of producing electrical current outside the cell. Rapidly developing microbial electrochemical technologies, such as microbial fuel cells, are part of a diverse platform of future sustainable energy and chemical production technologies. We review the key advances that will enable the use of exoelectrogenic microorganisms to generate biofuels, hydrogen gas, methane, and other valuable inorganic and organic chemicals. Moreover, we examine the key challenges for implementing these systems and compare them to similar renewable energy technologies. Although commercial development is already underway in several different applications, ranging from wastewater treatment to industrial chemical production, further research is needed regarding efficiency, scalability, system lifetimes, and reliability.

  11. Bioelectric signal classification using a recurrent probabilistic neural network with time-series discriminant component analysis.

    Science.gov (United States)

    Hayashi, Hideaki; Shima, Keisuke; Shibanoki, Taro; Kurita, Yuichi; Tsuji, Toshio

    2013-01-01

    This paper outlines a probabilistic neural network developed on the basis of time-series discriminant component analysis (TSDCA) that can be used to classify high-dimensional time-series patterns. TSDCA involves the compression of high-dimensional time series into a lower-dimensional space using a set of orthogonal transformations and the calculation of posterior probabilities based on a continuous-density hidden Markov model that incorporates a Gaussian mixture model expressed in the reduced-dimensional space. The analysis can be incorporated into a neural network so that parameters can be obtained appropriately as network coefficients according to backpropagation-through-time-based training algorithm. The network is considered to enable high-accuracy classification of high-dimensional time-series patterns and to reduce the computation time taken for network training. In the experiments conducted during the study, the validity of the proposed network was demonstrated for EEG signals.

  12. Tracking of anthropometric parameters and bioelectrical impedance in pubertal boys and girls.

    Science.gov (United States)

    Leppik, Aire; Jürimäe, Toivo; Jürimäe, Jaak

    2006-12-01

    The aim of this study was to investigate the anthropometric parameters and body impedance once per year during four years of the pubertal period in Estonian children. In total, 81 boys and 86 girls aged 10-11 years at the beginning of the study were investigated. Pubertal status was self-assessed by sexual maturation stages according to Tanner and physical activity index (PAI) according to Telama et al.. Body height and weight were measured and body mass index (BMI) calculated. In total, 9 skinfolds, 13 girths, 8 lengths and 8 breadths/lengths were measured according to the protocol of the International Society for the Advancement of Kinanthropometry. Somatotype components were estimated according to the method of Carter and Heath. Body impedance was measured using Multiscan 5000 (Bodystat, UK) and the impedance index (height/impedance) was calculated. The tracking of body height, weight, BMI, skinfolds, girths, lengths, breadth/lengths and body impedance was high (as a rule r> or =0.9). By increasing the time period, the correlation slightly decreased. In contrast, tracking correlations for PAI and Tanner stages were significant but quite low. Increase in mean body height was highest between 12-13 years of age (6.9 cm per year) in boys and in girls between 11-12 years of age (6.3 cm per year). In boys and girls, the peak increase in body weight was between 11 and 12 years of age, 5.7 kg and 5.2 kg, respectively. With the increasing age, body impedance decreased and impedance index increased. In conclusion, our results indicate that during puberty the detailed anthropometric parameters and body impedance tracked highly. However, the tracking of PAI and Tanner stages was significant but relatively low.

  13. A stable synergistic microbial consortium for simultaneous azo dye removal and bioelectricity generation.

    Science.gov (United States)

    Wang, Victor Bochuan; Chua, Song-Lin; Cai, Zhao; Sivakumar, Krishnakumar; Zhang, Qichun; Kjelleberg, Staffan; Cao, Bin; Loo, Say Chye Joachim; Yang, Liang

    2014-03-01

    Microbial species coexist in natural or engineered settings, where they encounter extensive competition and cooperation. Interactions occurring through metabolite exchange or direct contact might be important in establishment of functional biodegradation consortium. Understanding these interactions can facilitate manipulation of selected communities and exploitation of their capacity for specific industrial applications. Here, a simple dual-species consortium (Pseudomonas putida and Shewanella oneidensis) was established for examining simultaneous Congo red bioremediation in planktonic culture and power generation in anode biofilms. Compared to mono-species cultures, co-cultures generated higher current densities and could concurrently degrade Congo red over 72h. Disabling the large secreted adhesion protein, LapA, of P. putida greatly enhanced S. oneidensis biofilm formation on the anode, which increased power generation in co-cultures. This demonstrates simultaneous control of specific planktonic and biofilm communities could be effective in manipulating microbial communities for targeted applications.

  14. Application of body mass index adjusted for fat mass (BMIfat obtained by bioelectrical impedance in adults

    Directory of Open Access Journals (Sweden)

    Mírele Savegnago Mialich

    2014-08-01

    Full Text Available Introduction: Body mass index (BMI has been one of the methods most frequently used for diagnose obesity, but it isn't consider body composition. Objective: This study intends to apply one new adiposity index, the BMI adjusted for fat mass (BMIfat developed by Mialich, et al. (2011, in a adult Brazilian sample. Methods: A cross-sectional study with 501 individuals of both genders (366 women, 135 men aged 17 to 38 years and mean age was 20.4 ± 2.8 years, mean weight 63.0 ± 13.5 kg, mean height 166.9 ± 9.0 cm, and BMI 22.4 ± 3.4 kg/m². Results and discussion: High and satisfactory R2 values were obtained, i.e., 91.1%, 91.9% and 88.8% for the sample as a whole and for men and women, respectively. Considering this BMIfat were developed new ranges, as follows: 1.35 to 1.65 (nutritional risk for malnutrition, > 1.65 and ≤ 2.0 (normal weight and > 2.0 (obesity. The BMIfat had a more accurate capacity of detecting obese individuals (0.980. 0.993, 0.974 considering the sample as a whole and women and men, respectively, compared to the traditional BMI (0.932, 0.956, 0.95. Were also defined new cut-off points for the traditional BMI for the classification of obesity, i.e.: 25.24 kg/m² and 28.38 kg/m² for men and women, respectively. Conclusion: The BMIfat was applied for the present population and can be adopted in clinical practice. Further studies are needed to determine its application to different ethnic groups and to compare this index to others previously described in the scientific literature.

  15. Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in pseudomonas aeruginosa microbial fuel cells.

    Directory of Open Access Journals (Sweden)

    Victor Bochuan Wang

    Full Text Available The biosynthesis of the redox shuttle, phenazines, in Pseudomonas aeruginosa, an ubiquitous microorganism in wastewater microflora, is regulated by the 2-heptyl-3,4-dihydroxyquinoline (PQS quorum-sensing system. However, PQS inhibits anaerobic growth of P. aeruginosa. We constructed a P. aeruginosa strain that produces higher concentrations of phenazines under anaerobic conditions by over-expressing the PqsE effector in a PQS negative ΔpqsC mutant. The engineered strain exhibited an improved electrical performance in microbial fuel cells (MFCs and potentiostat-controlled electrochemical cells with an approximate five-fold increase of maximum current density relative to the parent strain. Electrochemical analysis showed that the current increase correlates with an over-synthesis of phenazines. These results therefore demonstrate that targeting microbial cell-to-cell communication by genetic engineering is a suitable technique to improve power output of bioelectrochemical systems.

  16. The use of bioelectrical impedance analysis for body composition in epidemiological studies

    DEFF Research Database (Denmark)

    Böhm, A; Heitmann, B L

    2013-01-01

    with increased risk of developing chronic diseases. Studies, among others using BIA, suggest that low BMI may reflect low muscle and high BMI fat mass (FM). BIA-derived lean and FM is directly associated with morbidity and mortality. To the contrary, BMI is rather of limited use for measuring BF...

  17. Development of NPP control room operators`s mental workload measurement system using bioelectric signals

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Bong Sik; Oh, In Seok; Lee, Hyun Cheol; Cha, Kyung Ho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Lee, Dong Ha [Suwon Univ., Suwon (Korea, Republic of)

    1996-09-01

    This study developed mentalload measurement system based on the relations between mentalload and physiological responses of the human operators. The measurement system was composed of the telemetry system for EEG, EOG, ECG and respiration pattern of the subjects, A/D converter, the physiological signal processing programs (compiled by the Labview). The signal processing programs transformed the physiological signal into the scores indicating mentalload status of the subjects and recorded the mentalload scores in the form of the table of a database. The acqknowledge and the labview programs additionally transformed the mentalload score database and the operator behavior database so that both database were consolidated into one. 94 figs., 57 refs. (Author).

  18. Malnutrition in remission of childhood cancers as assessed by bioelectric impedance analysis

    Directory of Open Access Journals (Sweden)

    M. V. Konovalova

    2014-07-01

    Full Text Available The results of our cross-sectional bioimpedance study of children aged 7–17 years cured of cancer during follow-up (patients’ group, n = 552, remission time range 0–15 years and of age-matched healthy controls (n = 1,500 show significant intergroup differences in body height and body composition parameters. The most pronounced alterations in the patients’ group were observed in standardized values of phase angle reflecting a sharp decrease in the percentage of metabolically active body cell mass in fat-free mass. Malnutrition, judged from the prevalence of obesity and low phase angle, was observed in 52.7 % of our patients reaching a maximum of 76.8 % in a subgroup of children with CNS tumors. In view of known association that exists between malnutrition and reduced tolerance to chemotherapy, increased susceptibility to infections and adverse outcomes rate, we recommend using bioimpedance analysis in remission of childhood cancers in order to monitoring and timely correction of nutritional state as well as for prevention of delayed cardiovascular risks.

  19. Malnutrition in remission of childhood cancers as assessed by bioelectric impedance analysis

    Directory of Open Access Journals (Sweden)

    M. V. Konovalova

    2012-01-01

    Full Text Available The results of our cross-sectional bioimpedance study of children aged 7–17 years cured of cancer during follow-up (patients’ group, n = 552, remission time range 0–15 years and of age-matched healthy controls (n = 1,500 show significant intergroup differences in body height and body composition parameters. The most pronounced alterations in the patients’ group were observed in standardized values of phase angle reflecting a sharp decrease in the percentage of metabolically active body cell mass in fat-free mass. Malnutrition, judged from the prevalence of obesity and low phase angle, was observed in 52.7 % of our patients reaching a maximum of 76.8 % in a subgroup of children with CNS tumors. In view of known association that exists between malnutrition and reduced tolerance to chemotherapy, increased susceptibility to infections and adverse outcomes rate, we recommend using bioimpedance analysis in remission of childhood cancers in order to monitoring and timely correction of nutritional state as well as for prevention of delayed cardiovascular risks.

  20. Sensitivity field distributions for segmental bioelectrical impedance analysis based on real human anatomy

    Science.gov (United States)

    Danilov, A. A.; Kramarenko, V. K.; Nikolaev, D. V.; Rudnev, S. G.; Salamatova, V. Yu; Smirnov, A. V.; Vassilevski, Yu V.

    2013-04-01

    In this work, an adaptive unstructured tetrahedral mesh generation technology is applied for simulation of segmental bioimpedance measurements using high-resolution whole-body model of the Visible Human Project man. Sensitivity field distributions for a conventional tetrapolar, as well as eight- and ten-electrode measurement configurations are obtained. Based on the ten-electrode configuration, we suggest an algorithm for monitoring changes in the upper lung area.

  1. Bioelectricity inhibits back diffusion from the anolyte into the desalinated stream in microbial desalination cells.

    Science.gov (United States)

    Ping, Qingyun; Porat, Oded; Dosoretz, Carlos G; He, Zhen

    2016-01-01

    Microbial desalination cells (MDCs) taking advantage of energy in wastewater to drive desalination represent a promising approach for energy-efficient desalination, but concerns arise whether contaminants in wastewater could enter the desalinated stream across ion exchange membranes. Such back diffusion of contaminants from the anolyte into the desalinated stream could be controlled by two mechanisms, Donnan effect and molecule transport. This study attempted to understand those mechanisms for inorganic and organic compounds in MDCs through two independently conducted experiments. Donnan effect was found to be the dominant mechanism under the condition without current generation. Under open circuit condition, the MDC fed with 5 g L(-1) salt solution exhibited 1.9 ± 0.7%, 10.3 ± 1.3%, and 1.8 ± 1.2% back diffusion of acetic, phosphate, and sulfate ions, respectively. Current generation effectively suppressed Donnan effect from 68.2% to 7.2%, and then molecule transport became more responsible for back diffusion. A higher initial salt concentration (35 g L(-1)) and a shorter HRT (1.0 d) led to the highest concentration gradient, resulting in the most back diffusion of 7.1 ± 1.2% and 6.8 ± 3.1% of phosphate and sulfate ions, respectively. Three representative organic compounds were selected for test, and it was found that organic back diffusion was intensified with a higher salt concentration gradient and molecular weight played an important role in compound movement. Principal component analysis confirmed the negative correlation between Donnan effect and current, and the positive correlation between molecule transport and concentration gradient related conditions.

  2. [Mechanisms of bioelectricity generation in Enterobacter aerogenes-based microbial fuel cells].

    Science.gov (United States)

    Zhang, Jin-Tao; Zhou, Shun-Gui; Zhang, Li-Xia; Lu, Na; Deng, Li-Fang; Ni, Jin-Ren

    2009-04-15

    Microbial fuel cells (MFCs) using hydrogen-producing bacteria (HPB) could utilize a large number of substrates to generate power. However, the coulombic efficiency is limited by the fact that only suspended cells are used as biocatalyst in anodic medium. MFCs using Fe (III)-reducing bacteria have high energy recovery efficiency, but can only utilize some simple organic matters. In this study, Enterobacter aerogenes XM02, a hydrogen-producing strain with Fe(III)-reducing activity, was selected as biocatalyst for MFCs, which could produce electricity by digesting lots of carbohydrates even starch. Graphite felt, a material with high specific surface area and hydrogen catalysis, instead of carbon paper supported platinum, was used as anode material. The coulombic efficiency had been substantially improved from 1.68% to 42.49%, higher than other HPB-based MFCs previously reported. The SEM image proved the ability of XM02 strain to colonize on the anode surface. Power generation of MFCs could restore quickly when anodic medium was completely replaced with non-growth medium containing glucose. This suggested that the attached cells contributed to electricity production because planktonic cells had been removed during the medium replacement. This study proposed the mechanism of power generated from in situ oxidation of hydrogen produced by the XM02 strain biofilm.

  3. Bioelectricity production from microbial fuel cell using mixed bacterial culture isolated from distillery wastewater.

    Science.gov (United States)

    Samsudeen, N; Radhakrishnan, T K; Matheswaran, Manickam

    2015-11-01

    The effect of various system parameters such as wastewater Chemical Oxygen Demand (COD) concentration, pH, conductivity, membrane size and thickness on efficient energy production using mixed isolated culture from the distillery wastewater in the MFC was studied. The power density increased with increase in the anolyte pH from 6 to 8. The peak power density and COD removal efficiency was observed as 63.8±0.65 mW/m(2) and 63.5±1.5% at pH 8, respectively. The MFC performance increased with increasing COD concentration (800-3200 mg/l), conductivity (1.1-9.7 mS/cm) and membrane area (8-24 cm(2)). The MFC operating with wastewater COD concentration of 3200 mg/l and its conductivity of 9.7 mS/cm produced the highest power density of 202±6 mW/m(2) with a corresponding current density of 412±12 mA/m(2). The results showed that the efficient electricity generation and simultaneous treatment of distillery wastewater can be attained in the MFC.

  4. Prediction of percentage body fat from anthropometry and bioelectrical impedance in Singaporean and Beijing Chinese

    NARCIS (Netherlands)

    Deurenberg, P.; Deurenberg-Yap, M.; Jingzhong Wang,; Fu Po Lin,; Schmidt, G.

    2000-01-01

    Body composition was measured in 205 male and female Beijing Chinese and in 148 male and female Singaporean Chinese, age 34 (mean) (range 18-68) years and body mass index (BMI) 22.3 (15.9-38.5) kg/m 2. In Beijing Siri's two-compartment model based on densitometry was used as a reference technique an

  5. Bioelectricity generation using two chamber microbial fuel cell treating wastewater from food processing.

    Science.gov (United States)

    Mansoorian, Hossein Jafari; Mahvi, Amir Hossein; Jafari, Ahmad Jonidi; Amin, Mohammad Mehdi; Rajabizadeh, Ahmad; Khanjani, Narges

    2013-05-10

    Electricity generation from microbial fuel cells which treat food processing wastewater was investigated in this study. Anaerobic anode and aerobic cathode chambers were separated by a proton exchange membrane in a two-compartment MFC reactor. Buffer solutions and food industry wastewater were used as electrolytes in the anode and cathode chambers, respectively. The produced voltage and current intensity were measured using a digital multimeter. Effluents from the anode compartment were tested for COD, BOD5, NH3, P, TSS, VSS, SO4 and alkalinity. The maximum current density and power production were measured 527mA/m(2) and 230mW/m(2) in the anode area, respectively, at operation organic loading (OLR) of 0.364g COD/l.d. At OLR of 0.182g COD/l.d, maximum voltage and columbic efficiency production were recorded 0.475V and 21%, respectively. Maximum removal efficiency of COD, BOD5, NH3, P, TSS, VSS, SO4 and alkalinity were 86, 79, 73, 18, 68, 62, 30 and 58%, respectively. The results indicated that catalysts and mediator-less microbial fuel cells (CAML-MFC) can be considered as a better choice for simple and complete energy conversion from the wastewater of such industries and also this could be considered as a new method to offset wastewater treatment plant operating costs.

  6. The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG).

    Science.gov (United States)

    Itil, T M

    1983-01-01

    Antidepressant properties of six compounds were predicted based on their computer-analyzed human electroencephalographical (CEEG) profiles. The clinical investigations with mianserin (GB-94) confirmed the CEEG prediction. This compound has now been marketed as the first antidepressant of which the clinical effects were discovered solely by the quantitative pharmaco-EEG method. As predicted by the CEEG, clinical antidepressant properties of GC-46, mesterolone, and estradiol valerate were observed in preliminary investigations. No extensive studies with definite statistical results were yet carried out with these compounds. No systematic large studies could be conducted with cyclozocine and cyproterone acetate because of the intolerable side effects with these compounds. The optical isomers of mianserin, GF-59 and GF-60, both predicted as antidepressant by the computer EEG data base, have not yet been tested in depressive patients. None of these compounds possess the "typical" pharmacological and/or biochemical profiles of marketed antidepressants. Thus, the discovery of the established antidepressant properties of mianserin (GB-94) by computer analyzed EEG method challenges the well-known biochemical hypotheses of depression and the "classical" development of antidepressant drugs.

  7. ACETONE REMOVAL AND BIOELECTRICITY GENERATION IN DUAL CHAMBER MICROBIAL FUEL CELL

    Directory of Open Access Journals (Sweden)

    Mostafa Rahimnejad

    2012-01-01

    Full Text Available Synthetic waste water contain organic compound can be oxidized in an anaerobic conditions in microbial fuel cell while biodegradation of Chemical Oxygen Demand (COD takes place under anaerobic condition in anode compartment. The microorganisms for biological treatment of the organic matter were obtained from a UASFB bioreactor. In the treatment of waste water, ones COD was removed the current and power was generated and record. Also polarization curve was obtained. In cathode compartment ferocynide and potassium permanganate with several concentration were add for enhancement of proton oxidation. The performance of MFC for maximum current and power generation were obtained with 300 µM L-1 potassium permanganate as oxidizers agent. Maximum generated power and current densities were 22 mW/m2 and 70 mA/m2, respectively. Active microorganisms used acetone as electron donors and COD removal was 69% at the end of process.

  8. Feasibility of bioelectrical impedance analysis in children with a severe generalized cerebral palsy

    NARCIS (Netherlands)

    R. Veugelers (Rebekka); C. Penning (Corine); L. van Gulik (Laura); D. Tibboel (Dick); H.M. Evenhuis (Heleen)

    2006-01-01

    textabstractObjective: The need is strong for an accurate and easy-to-perform test to evaluate the nutritional state of children who have a severe generalized cerebral palsy, defined as a severe motor handicap and an intellectual disability. For that purpose, we determined the feasibility of bioelec

  9. Pengembangan Bioelectrical Impedance Sebagai Control Commands Pengaturan Kecepatan Gerak Kursi Roda Dengan Metoda PID Controller

    Directory of Open Access Journals (Sweden)

    Juli Sardi

    2014-09-01

    Full Text Available In the present study, bioimpedance signals of human body was utilized to control speed of a wheelchair movement. A bioimpedance is electrically passive part contained the body tissues. The research is one of alternative solutions for patients with paralysis of the upper and lower limb. Firstly, design of system of the research consisted of bioimpedance measuring instruments and a mechanical design of the wheelchair. Bioimpedance measurement was performed by injecting a sinusoidal current source of 0.5 mArms with a frequency of 50 kHz to muscle tissue (shoulder to obtain the output voltage in the range of 0-5 Vdc. With impulse and manual thresholding methods, the voltage signal was classified into several controls command to adjust the speed and direction of the wheelchair control based on PID Controller. The experimental result of the research was realization of bioimpedance signal that used as a reference to control the direction and speed of the wheelchair with a success rate of 86.7 %. A wheelchair velocity was classified into three types of motion, namely slow, medium and fast. Slow speed has a rated speed of 30 Cm/s, medium speed value speed of 40 Cm/s and fast speed value of 50 Cm/s. The wheelchair can also turn to the left and the right in accordance with the wishes of wheelchair user beside to moving forward.

  10. Bioelectricity Generation in a Microbial Fuel Cell with a Self-Sustainable Photocathode

    Directory of Open Access Journals (Sweden)

    Ting Liu

    2015-01-01

    Full Text Available This study aims to construct an MFC with a photosynthetic algae cathode, which is maintained by self-capturing CO2 released from the anode and utilizing solar energy as energy input. With this system, a maximum power density of 187 mW/m2 is generated when the anode off gas is piped into the catholyte under light illumination, which is higher than that of 21 mW/m2 in the dark, demonstrating the vital contribution of the algal photosynthesis. However, an unexpected maximum power density of 146 mW/m2 is achieved when the anode off gas is not piped into the catholyte. Measurements of cathodic microenvironments reveal that algal photosynthesis still takes place for oxygen production under this condition, suggesting the occurrence of CO2 crossover from anode to cathode through the Nafion membrane. The results of this study provide further understanding of the algae-based microbial carbon capture cell (MCC and are helpful in improving MCC performance.

  11. Comparison of body fat in Brazilian adult females by bioelectrical impedance analysis

    Science.gov (United States)

    Altamir, Vaz; Frère, Slaets Annie France; Ramírez Leonardo, López

    2012-12-01

    Body-fat is essential for human body, provided that its amount is at healthy levels. If in-excess body-fat is deleterious, its lack is otherwise also harmful. Estimated percent body-fat performed with commercially available devices measuring bioimpedance have many advantages, such as easy measurement and low cost. However, these measurements are based on standard models and equations that are not disclosed by manufacturers, and this leads to questioning the validity of these estimates for Brazilian females. The aim of this study was to compare electrical tetrapolar and octapolar impedance results obtained with commercially available equipment: Maltron BF-906 and OMRON 510-W. Data analysis involved descriptive and inferential statistics. Devices used in this study to estimate body fat quantity have not shown any significant differences in results; this is a major issue when selecting equipment based on three factors: study focus, available financial resources, and target population. Results obtained from the two devices have not shown any significant differences, which lead to the conclusion that either device may be reliably used.

  12. Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs

    Energy Technology Data Exchange (ETDEWEB)

    Song, B.; Wang, B.N.; Chen, D.N.; Luo, Z.G. [Department of Cardiovascular Medicine, The First Affiliated Hospital, Anhui Medical University, HeFei, Anhui Province (China)

    2013-09-06

    In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.

  13. The influence of the run intensity on bioelectrical activity of selected human leg muscles.

    Science.gov (United States)

    Mastalerz, Andrzej; Gwarek, Lucyna; Sadowski, Jerzy; Szczepański, Tadeusz

    2012-01-01

    The purpose of this work was to investigate the electromyographic (EMG) fatigue representations in muscles of male runners during run at different level of intensity. In this study, the EMG signals for the rectus femoris and biceps femoris (long head) were collected by bipolar electrodes from the left and right lower extremities. EMG measurements were recorded during the run on tartan athletic track. Four professional athletes had to run a 400 m distance with a different intensity. The first distance of 400 m took 90 s; the second, 70 s; the third, 60 s; and the last one was covered with a maximal velocity until exhaustion. Power spectral analysis of EMG signals was carried out to calculate MPF. The results of our study revealed the efforts of different intensity for each muscle individually. The effect of fatigue was observed only in the case of running with the highest velocity. The biggest changes in MPF were observed for BF (23.6%) and RF (19.5%) muscles of the left leg and then for BF (17.5%) and RF (12.5%) ones of the right leg. We supposed that those differences between the right and left legs were mainly due to the curve of the track where those muscles are differently loaded.

  14. Body composition of Bangladeshi children: comparison and development of leg-to-leg bioelectrical impedance equation.

    Science.gov (United States)

    Khan, Ashraful I; Hawkesworth, Sophie; Hawlader, Mohammad Delwer Hossain; El Arifeen, Shams; Moore, Sophie; Hills, Andrew P; Wells, Jonathan C; Persson, Lars-Åke; Kabir, Iqbal

    2012-09-01

    The aim of this study was to investigate the validity of the Tanita TBF 300A leg-to-leg bioimpedance analyzer for estimating fat-free mass (FFM) in Bangladeshi children aged 4-10 years and to develop novel prediction equations for use in this population, using deuterium dilution as the reference method. Two hundred Bangladeshi children were enrolled. The isotope dilution technique with deuterium oxide was used for estimation of total body water (TBW). FFM estimated by Tanita was compared with results of deuterium oxide dilution technique. Novel prediction equations were created for estimating FFM, using linear regression models, fitting child's height and impedance as predictors. There was a significant difference in FFM and percentage of body fat (BF%) between methods (pmodel with height and impedance explained 83% of the variance in FFM estimated by deuterium oxide dilution technique. The best-fit equation to predict FFM from linear regression modelling was achieved by adding weight, sex, and age to the basic model, bringing the adjusted R² to 89% (standard error=0.90, p<0.001). These data suggest Tanita analyzer may be a valid field-assessment technique in Bangladeshi children when using population-specific prediction equations, such as the ones developed here.

  15. [ABDOMINAL BIOELECTRICAL IMPEDANCE ANALYSIS AND ANTHROPOMETRY FOR PREDICTING METABOLIC SYNDROME IN MIDDLE AGED MEN].

    Science.gov (United States)

    Fernández-Vázquez, Rosalía; Millán Romero, Ángel; Barbancho, Miguel Ángel; Alvero-Cruz, José Ramón

    2015-09-01

    Objetivo: la obesidad central tiene una gran relación con el síndrome metabólico. Estudiar la relación de la grasa del tronco, el índice de grasa visceral y las medidas antropométricas con el síndrome metabólico. Métodos: diseño: transversal descriptivo y correlacional. Participaron 75 varones, voluntarios, de distintas profesiones, que accedieron a un reconocimiento médico- laboral, con un rango de edad de 21 a 59 años. Mediciones de peso, talla, índice de masa corporal, perímetro abdominal, perímetro glúteo, índice cintura-cadera y grasa de tronco y nivel de grasa visceral mediante bioimpedanciometría (Tanita AB-140-ViScan) y parámetros bioquímicos: glucosa, colesterol total y triglicéridos. Así mismo, se midió la presión arterial sistólica y diastólica. Se comparan los estados de síndrome metabólico, sobrepeso y obesidad. Resultados: existen correlaciones de las medidas antropométricas con la de grasa de tronco y el nivel de grasa visceral, así como con los parámetros bioquímicos (p obesidad y síndrome metabólico. Conclusiones: la grasa de tronco y los niveles de grasa visceral son muy sensibles y específicos para la detección del síndrome metabólico y la obesidad, aunque no superan a las variables e índices antropométricos. En la condición de sobrepeso, la grasa de tronco y visceral son medidas algo más predictivas que las variables antropométricas.

  16. Mutual facilitations of food waste treatment, microbial fuel cell bioelectricity generation and Chlorella vulgaris lipid production.

    Science.gov (United States)

    Hou, Qingjie; Pei, Haiyan; Hu, Wenrong; Jiang, Liqun; Yu, Ze

    2016-03-01

    Food waste contains large amount of organic matter that may be troublesome for handing, storage and transportation. A microbial fuel cell (MFC) was successfully constructed with different inoculum densities of Chlorella vulgaris for promoting food waste treatment. Maximum COD removal efficiency was registered with 44% and 25 g CODL(-1)d(-1) of substrate degradation rate when inoculated with the optimal initial density (150 mg L(-1)) of C. vulgaris, which were 2.9 times and 3.1 times higher than that of the abiotic cathode. With the optimum inoculum density of C. vulgaris, the highest open circuit voltage, working voltage and power density of MFC were 260 mV, 170 mV and 19151 mW m(-3), respectively. Besides the high biodiesel quality, promoted by MFC stimulation the biomass productivity and highest total lipid content of C. vulgaris were 207 mg L(-1)d(-1) and 31%, which were roughly 2.7 times and 1.2 times higher than the control group.

  17. Spatial dynamics of bioelectrical processes of brain during prolonged contact with physical factors

    Energy Technology Data Exchange (ETDEWEB)

    Suvorov, N.B.; Kukhtina, G.V.

    Study of the spatial organization of the EEG activity of the brain of man under normal circumstances and under prolonged effect of superhigh frequency electromagnetic fields involved examination of 155 workers ranging in age from 20 up to 39 years and working while exposed to electromagnetic fields for periods ranging from 2 up to 20 years and selection, from these, of 34 persons with no cerebral-cranial trauma, neuroinfection, psychotrauma, somatic or other diseases in their anamnesis for neurophysiological study. Monopolar EEG and EKG were registered during work and at psychosensory rest. Plasticity of the subjects' neurodynamic processes was assessed during voluntary regulation of the alpha-rhythm. Graphs of spatial-discrete interaction of isoelectric states of the EEG of the various zones of the brain were recorded by a digital computer. Prolonged periods of work while exposed to superhigh frequency electromagnetic fields produces phase changes of the spatial-discrete organization of neurorhythms of the brain. Working under these conditions for periods from 7 up to 14 years produces stress on the adaptational potentials of the organism and causes asthenization of mechanisms of self-regulation of the brain, which disturbs other functions of the organism. The maximum permissible period of work under these conditions is 7-14 years. 22 references, 4 figures.

  18. Bioelectrical impedance spectroscopy as a fluid management system in heart failure.

    Science.gov (United States)

    Weyer, Sören; Zink, Matthias Daniel; Wartzek, Tobias; Leicht, Lennart; Mischke, Karl; Vollmer, Thomas; Leonhardt, Steffen

    2014-06-01

    Episodes of hospitalization for heart failure patients are frequent and are often accompanied by fluid accumulations. The change of the body impedance, measured by bioimpendace spectroscopy, is an indicator of the water content. The hypothesis was that it is possible to detect edema from the impedance data. First, a finite integration technique was applied to test the feasibility and allowed a theoretical analysis of current flows through the body. Based on the results of the simulations, a clinical study was designed and conducted. The segmental impedances of 25 patients suffering from heart failure were monitored over their recompensation process. The mean age of the patients was 73.8 and their mean body mass index was 28.6. From these raw data the model parameters from the Cole model were deduced by an automatic fitting algorithm. These model data were used to classify the edema status of the patient. The baseline values of the regression lines of the extra- and intracellular resistance from the transthoracic measurement and the baseline value of the regression line of the extracellular resistance from the foot-to-foot measurement were identified as important parameters for the detection of peripheral edema. The rate of change of the imaginary impedance at the characteristic frequency and the mean intracellular resistance from the foot-to-foot measurement were identified as important parameters for the detection of pulmonary edema. To classify the data, two decision trees were considered: One should detect pulmonary edema (n(pulmonary) = 13, n(none) = 12) and the other peripheral edema (n(peripheral) = 12, n(none) = 13). Peripheral edema could be detected with a sensitivity of 100% and a specificity of 90%. The detection of pulmonary edema showed a sensitivity of 92.31% and a specificity of 100%. The leave-one-out cross-validation-error for the peripheral edema detection was 12% and 8% for the detection of pulmonary edema. This enables the application of BIS as an early warning system for cardiac decompensation with the potential to optimize patient care.

  19. Bioelectrical impedance analysis (BIA) for sarcopenic obesity (SO) diagnosis in young female subjects

    Science.gov (United States)

    González-Correa, C. H.; Caicedo-Eraso, J. C.; S, Villada-Gomez J.

    2013-04-01

    Sarcopenia is defined as a loss of muscle mass depending of ageing and affecting physical function (definition A). A new definition considers excluding mass reduction criterion (definition B). Obesity is pandemic and occurs at all ages. Sarcopenic obesity (SO) implies both processes. The purpose of this study was to compare the results obtained after applying these 2 definitions in 66 aged 22 ± 2.8 years overweight or obese young college women. Percentage body fat (%BF) and skeletal mass index (SMI) were estimated by BIA, muscle function by handgrip strength test (HGS) and physical performance by Harvard step test (HST). There were 9.1% and 90.9% overweight or obese subjects. Twenty nine subjects (43.9%) had decreased HGS and 22 (33.3%) had impaired physical performance. One obese subject (1.5%) met the criteria for sarcopenic obesity by definition A and 9 (13.6%) by definition B. Although a linear regression (α obese, the problematic of SO will be found earlier in life.

  20. Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells

    DEFF Research Database (Denmark)

    Wang, Victor Bochuan; Chua, Song-Lin; Cao, Bin;

    2013-01-01

    . aeruginosa strain that produces higher concentrations of phenazines under anaerobic conditions by over-expressing the PqsE effector in a PQS negative ΔpqsC mutant. The engineered strain exhibited an improved electrical performance in microbial fuel cells (MFCs) and potentiostat-controlled electrochemical...... cells with an approximate five-fold increase of maximum current density relative to the parent strain. Electrochemical analysis showed that the current increase correlates with an over-synthesis of phenazines. These results therefore demonstrate that targeting microbial cell-to-cell communication...... by genetic engineering is a suitable technique to improve power output of bioelectrochemical systems....

  1. Production of bioelectricity, bio-hydrogen, high value chemicals and bioinspired nanomaterials by electrochemically active biofilms.

    Science.gov (United States)

    Kalathil, Shafeer; Khan, Mohammad Mansoob; Lee, Jintae; Cho, Moo Hwan

    2013-11-01

    Microorganisms naturally form biofilms on solid surfaces for their mutual benefits including protection from environmental stresses caused by contaminants, nutritional depletion or imbalances. The biofilms are normally dangerous to human health due to their inherited robustness. On the other hand, a recent study suggested that electrochemically active biofilms (EABs) generated by electrically active microorganisms have properties that can be used to catalyze or control the electrochemical reactions in a range of fields, such as bioenergy production, bioremediation, chemical/biological synthesis, bio-corrosion mitigation and biosensor development. EABs have attracted considerable attraction in bioelectrochemical systems (BESs), such as microbial fuel cells and microbial electrolysis cells, where they act as living bioanode or biocathode catalysts. Recently, it was reported that EABs can be used to synthesize metal nanoparticles and metal nanocomposites. The EAB-mediated synthesis of metal and metal-semiconductor nanocomposites is expected to provide a new avenue for the greener synthesis of nanomaterials with high efficiency and speed than other synthetic methods. This review covers the general introduction of EABs, as well as the applications of EABs in BESs, and the production of bio-hydrogen, high value chemicals and bio-inspired nanomaterials.

  2. EFFECTS OF FOOD AND DRINK INGESTION ON BODY COMPOSITION VARIABLES OF ABDOMINAL BIOELECTRICAL IMPEDANCE.

    Science.gov (United States)

    Fernández Vázquez, Rosalía; Martínez Blanco, Javier; García Vega, María del Mar; Barbancho, Miguel Ángel; Alvero-Cruz, José Ramón

    2015-11-01

    Objetivo: conocer los cambios en la grasa del tronco y el nivel de grasa visceral determinado por BIA abdominal, así como otras medidas antropométricas relacionadas con la grasa abdominal o central después de la ingestión de una comida. Métodos: se realizó un protocolo experimental para evaluar un estudio descriptivo de intervención longitudinal. Los participantes fueron 21 sujetos (10 hombres y 11 mujeres), voluntarios que tuvieron acceso a una evaluación médica, con una edad de 74 años ± 13,43. Las mediciones antropométricas fueron: circunferencia de la cintura máxima en posición de pie, circunferencia de la cintura a nivel del ombligo en posición de decúbito supino y diámetro sagital abdominal (SAD). Además se obtuvo la grasa del tronco y el nivel de grasa visceral, por análisis de impedancia bioeléctrica abdominal, con un dispositivo Tanita AB-140 (ViScan), todo ello antes y después de una ración de comida. Resultados: las medidas antropométricas, como la circunferencia de la cintura en posición supina y SAD, no mostraron diferencias significativas (P > 0,05), después de la ingestión de alimentos, a excepción de un aumento significativo de la circunferencia de la cintura máxima en posición de pie (P 0,05). Los cambios porcentuales de las medidas fueron menores del 2% para la circunferencia de la cintura en posición de pie, para la circunferencia de cintura por Viscan, para el diámetro sagital abdominal y la grasa del tronco, y un 5,9% para el nivel de grasa visceral. Conclusiones: los efectos de una comida y bebida sobre la grasa del tronco y el nivel de grasa visceral, medidas por impedancia bioeléctrica abdominal, son mínimas, aunque siempre es recomendable hacerlo en condiciones de ayuno.

  3. Neurone bioelectric activity under magnetic fields of variable frequency in the range of 0.1-80 Hz

    Energy Technology Data Exchange (ETDEWEB)

    Perez Bruzon, R.N.; Azanza, M.J. E-mail: mjazanza@posta.unizar.es; Calvo, Ana C.; Moral, A. del

    2004-05-01

    Intracellular recordings from single unit molluscan neurones under exposure to ELF-MF (1 mT, 0.1-80 Hz), show that neurone frequency activity, f, decreases with the applied magnetic field frequency, f{sub M}, a phenomenon which indicates a frequency-window effect for the neurone membrane response. The HMHW of the window amounts between 2-10 Hz. An explanation of this phenomenon is proposed.

  4. Neurone bioelectric activity under magnetic fields of variable frequency in the range of 0.1-80 Hz

    Science.gov (United States)

    Pérez Bruzón, R. N.; Azanza, María. J.; Calvo, Ana C.; del Moral, A.

    2004-05-01

    Intracellular recordings from single unit molluscan neurones under exposure to ELF-MF (1 mT, 0.1-80 Hz), show that neurone frequency activity, f, decreases with the applied magnetic field frequency, fM, a phenomenon which indicates a frequency-window effect for the neurone membrane response. The HMHW of the window amounts between 2-10 Hz. An explanation of this phenomenon is proposed.

  5. [Effect of refeeding on the body composition of females with restrictive anorexia nervosa; anthropometry versus bioelectrical impedance].

    Science.gov (United States)

    de Mateo Silleras, Beatriz; Redondo del Río, Paz; Camina Martín, Alicia; Soto Célix, María; Alonso Torre, Sara R; Miján de la Torre, Alberto

    2013-01-01

    Objetivo: Evaluar la composición corporal en un grupo de pacientes desnutridas con anorexia nerviosa, respecto de controles sanas, antes y después del soporte nutricional, mediante antropometría y bioimpedancia. Métodos: Estudio observacional prospectivo. Se realizó una antropometría completa y un análisis de bioimpedancia a 12 mujeres con anorexia nerviosa restrictiva (24,5 años) al ingreso hospitalario y semanalmente durante la realimentación. El grupo control estuvo formado por 24 mujeres sanas (21 años). Se aplicaron los test t-Student, U-Mann-Whitney, t-Student para medidas repetidas o Wilcoxon. La concordancia entre antropometría y BIA se analizó mediante el coeficiente de correlación intraclase y Bland-Altman. Resultados: Las pacientes mejoraron significativamente todos los índices de composición corporal a lo largo de la estancia hospitalaria, aunque sus valores al alta siguieron siendo menores que los de las controles. La media de peso ganado fue 5,22 kg (DE: 1,42), de los que el 51,4% fueron masa grasa, con distribución central preferentemente. En las controles la ecuación de BIA que mejor concuerda con antropometría es la de Sun (CCI = 0,896); en las pacientes la concordancia fue más débil, al ingreso y al alta. Conclusiones: La realimentación produce una ganancia ponderal, fundamentalmente a expensas de masa grasa, con distribución central; no se consigue restablecer el estado nutricional. La concordancia entre antropometría y bioimpedancia para el estudio de la composición corporal es aceptable, especialmente en sujetos sanos. Se recomienda emplear antropometría, si no se dispone de BIA vectorial o algún método gold estandard para el análisis de la composición corporal, en casos de alteraciones importantes en la composición corporal y/o el balance hídrico.

  6. Diadenosine tetra- and pentaphosphates affect contractility and bioelectrical activity in the rat heart via P2 purinergic receptors.

    Science.gov (United States)

    Pustovit, Ksenia B; Kuzmin, Vladislav S; Abramochkin, Denis V

    2016-03-01

    Diadenosine polyphosphates (Ap(n)As) are endogenously produced molecules which have been identified in various tissues of mammalian organism, including myocardium. Ap(n)As contribute to the blood clotting and are also widely accepted as regulators of blood vascular tone. Physiological role of Ap(n)As in cardiac muscle has not been completely elucidated. The present study aimed to investigate the effects of diadenosine tetra- (Ap4A) and penta- (Ap5A) polyphosphates on contractile function and action potential (AP) waveform in rat supraventricular and ventricular myocardium. We have also demonstrated the effects of A4pA and Ap5A in myocardial sleeves of pulmonary veins (PVs), which play a crucial role in genesis of atrial fibrillation. APs were recorded with glass microelectrodes in multicellular myocardial preparations. Contractile activity was measured in isolated Langendorff-perfused rat hearts. Both Ap4A and Ap5A significantly reduced contractility of isolated Langendorff-perfused heart and produced significant reduction of AP duration in left and right auricle, interatrial septum, and especially in right ventricular wall myocardium. Ap(n)As also shortened APs in rat pulmonary veins and therefore may be considered as potential proarrhythmic factors. Cardiotropic effects of Ap4A and Ap5A were strongly antagonized by selective blockers of P2 purine receptors suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS), while P1 blocker DPCPX was not effective. We conclude that Ap(n)As may be considered as new class of endogenous cardioinhibitory compounds. P2 purine receptors play the central role in mediation of Ap4A and Ap5A inhibitory effects on electrical and contractile activity in different regions of the rat heart.

  7. Impact of Different Body Positions on Bioelectrical Activity of the Pelvic Floor Muscles in Nulliparous Continent Women

    Directory of Open Access Journals (Sweden)

    Daria Chmielewska

    2015-01-01

    Full Text Available We examined pelvic floor muscles (PFM activity (%MVC in twenty nulliparous women by body position during exercise as well as the activation of abdominal muscles and the gluteus maximus during voluntary contractions of the PFMs. Pelvic floor muscle activity was recorded using a vaginal probe during five experimental trials. Activation of transversus abdominis, rectus abdominis, and gluteus maximus during voluntary PFM contractions was also assessed. Significant differences in mean normalized amplitudes of baseline PFM activity were revealed between standing and lying (P<0.00024 and lying and ball-sitting positions (P<0.0053. Average peak, average time before peak, and average time after peak did not differ significantly during the voluntary contractions of the PFMs. Baseline PFM activity seemed to depend on the body position and was the highest in standing. Pelvic floor muscles activity during voluntary contractions did not differ by position in continent women. Statistically significant differences between the supine lying and sitting positions were only observed during a sustained 60-second contraction of the PFMs.

  8. Interference of heart and transcutaneous oxygen monitoring in the measurement of bioelectrical impedance analysis in preterm newborns

    Directory of Open Access Journals (Sweden)

    Viviane C. Comym

    Full Text Available Abstract Objective: To verify if the connection of electrodes for heart and transcutaneous oxygen monitoring interfere with the measurement of electrical bioimpedance in preterm newborns. Methods: This was a prospective, blinded, controlled, cross-sectional, crossover study that assessed and compared paired measures of resistance (R and reactance (Xc by BIA, obtained with and without monitoring wires attached to the preterm newborn. The measurements were performed in immediate sequence, after randomization to the presence or absence of electrodes. The sample size calculated was 114 measurements or tests with monitoring wires and 114 without monitoring wires, considering for a difference between the averages of 0.1 ohms, with an alpha error of 10% and beta error of 20%, with significance <0.05. Results: No differences were observed between the R (677.37 ± 196.07 vs. 677.46 ± 194.86 and Xc (31.15 ± 9.36 vs. 31.01 ± 9.56 values obtained with and without monitoring wires, respectively, with good correlation between them (R: 0.997 and Xc: 0.968. Conclusion: The presence of heart and/or transcutaneous oxygen monitoring wires connected to the preterm newborn did not affect the values of R or Xc measured by BIA, allowing them to be carried out in this population without risks.

  9. 生物电阻抗技术研究进展%The Development of the Bioelectric Impedance Technologies

    Institute of Scientific and Technical Information of China (English)

    董秀珍

    2004-01-01

    本文从生物电阻抗血流图(bioimpedance rheohepatogram)、生物电阻抗测量(bioimpedance measurement)、生物组织阻抗频谱特性(bioimpedance spextroscopy)、生物电阻抗成像(electrical impedance imaging)等方面结合自己的研究工作,较全面地介绍并讨论了生物电阻抗技术的研究进展情况.

  10. Bioelectric impedance overestimates the body fat in overweight and underestimates in Brazilian obese women: a comparation with Segal equation 1

    OpenAIRE

    Pimentel, G. D.; Bernhard, A. B. [UNESP; M. R. P. Frezza; Rinaldi, A. E. M. [UNESP; Roberto Carlos BURINI

    2010-01-01

    Introduction: Overweight and obesity are risk factors to appearance of cardiovascular diseases and anthropometry is important as clinical tool for planning and health policymaking at population level. Thus, aim of this work was to compare the simple body fat percentage (%BF) obtained straight by bioeletric impedance (BIA) to the one obtained by the equation of Segal et al (1988), which uses the BIA resistance value, overweight among adult women.Methods: This study conducted with 86 adult wome...

  11. The comparative evaluation of patients′ body dry weight under hemodialysis using two methods: Bioelectrical impedance analysis and conventional method

    Directory of Open Access Journals (Sweden)

    Neda Alijanian

    2012-01-01

    Full Text Available Background: Dry weight (DW is an important concept related to patients undergoing hemodialysis. Conventional method seems to be time consuming and operator dependent. Bio impedance analysis (BIA is a new and simple method reported to be an accurate way for estimating DW. In this study, we aimed to compare the conventional estimation of DW with measuring DW by BIA. Materials and Methods: This study involved 130 uremic patients, performed in Isfahan, Iran. DW was calculated by both conventional (CDW and BIA (BIADW method and results were compared based on different grouping factors including sex, underlying cause of renal failure (RF (diabetic RF and non-diabetic RF, body mass index (BMI status, and sessions of hemodialysis. We also calculated the difference between DWs of 2 methods (DW diff = CDW-BIADW. Results: The mean of BIADW was significantly lower than CDW (57.20 ± 1.82 vs 59.36 ± 1.77, P value < 0.001. After grouping cases according to the underlying cause, BMI, sex, and dialysis sessions BIADW was significantly lower than CDW. Conclusion: Based on the combination of problems with CDW measurement which are corrected by BIA, and more clinical reliability of CDW, we concluded that although conventional method is a time-consuming and operator-dependent way to assess DW, DW could be estimated by combining both of these methods by finding the mathematic correlation between these methods.

  12. DXA, bioelectrical impedance, ultrasonography and biometry for the estimation of fat and lean mass in cats during weight loss

    Directory of Open Access Journals (Sweden)

    Borges Naida C

    2012-07-01

    Full Text Available Abstract Background Few equations have been developed in veterinary medicine compared to human medicine to predict body composition. The present study was done to evaluate the influence of weight loss on biometry (BIO, bioimpedance analysis (BIA and ultrasonography (US in cats, proposing equations to estimate fat (FM and lean (LM body mass, as compared to dual energy x-ray absorptiometry (DXA as the referenced method. For this were used 16 gonadectomized obese cats (8 males and 8 females in a weight loss program. DXA, BIO, BIA and US were performed in the obese state (T0; obese animals, after 10% of weight loss (T1 and after 20% of weight loss (T2. Stepwise regression was used to analyze the relationship between the dependent variables (FM, LM determined by DXA and the independent variables obtained by BIO, BIA and US. The better models chosen were evaluated by a simple regression analysis and means predicted vs. determined by DXA were compared to verify the accuracy of the equations. Results The independent variables determined by BIO, BIA and US that best correlated (p r2, 19 equations were selected (12 for FM, 7 for LM; however, only 7 equations accurately predicted FM and one LM of cats. Conclusions The equations with two variables are better to use because they are effective and will be an alternative method to estimate body composition in the clinical routine. For estimated lean mass the equations using body weight associated with biometrics measures can be proposed. For estimated fat mass the equations using body weight associated with bioimpedance analysis can be proposed.

  13. Prediction of fat-free body mass from bioelectrical impedance and anthropometry among 3-year-old children using DXA

    DEFF Research Database (Denmark)

    Ejlerskov, Katrine Tschentscher; Jensen, Signe Marie; Christensen, Line B

    2014-01-01

    -validation approach. Prediction error of FFM was 3.0% for both equations (root mean square error: 360 and 356 g, respectively). The derived equations produced BIA-based prediction of FFM and FM near DXA scan results. We suggest that the predictive equations can be applied in similar population samples aged 2-4 years...

  14. Calibration of bioelectrical impedance analysis for body composition assessment in Ethiopian infants using air-displacement plethysmography

    DEFF Research Database (Denmark)

    Christensen, Rasmus Wibæk; Kæstel, Pernille; Skov, R.

    2015-01-01

    on BIA in 0- to 6-month-old Ethiopian infants. SUBJECTS/METHODS: The study comprised a total of 186 BC assessments performed in 101 healthy infants, delivered at Jimma University Specialized Hospital. Infant air-displacement plethysmography (IADP) was the criterion method, whereas weight, length, sex...... by IADP, with an adjusted R(2) and root mean square error (RMSE) of 0.94 and 200 g, respectively. Adding impedance index to the model resulted in a significantly improved model fit (R(2)=0.95; RMSE=181 g). For infants below 3 months of age, inclusion of impedance index did not contribute to an improved...... model fit for predicting FFM compared with a model already comprising weight, sex and age. CONCLUSIONS: The derived equations predicted FFM with acceptable accuracy and may be used in future field surveys, epidemiological studies and clinical trials conducted in similar sub-Saharan African population...

  15. Effectiveness of thigh-to-thigh current path for the measurement of abdominal fat in bioelectrical impedance analysis.

    Science.gov (United States)

    Hong, Ki Hwan; Lim, Yong Gyu; Park, Kwang Suk

    2009-12-01

    We present a new method measuring body impedance using a thigh-to-thigh current path, which can reflect the abdominal fat portion more sensitively and can be conveniently applied during the daily use on a toilet seat. Two pairs of electrodes were installed on a toilet seat to provide current and to permit voltage measurement through a thigh-to-thigh current path. The effectiveness of the method was compared with conventional foot-to-foot and hand-to-foot current paths by simulation and by experiments referenced to computed tomography (CT) image analysis. Body impedance using three different current paths was measured, and abdominal CT images were acquired for eight subjects. Measured body impedances were compared with the visceral to subcutaneous fat ratio (VF/SF) calculated from the CT-determined abdominal fat volume. The thigh-to-thigh current path was about 75% more sensitive in abdominal fat measurement than the conventional current paths in simulation experiments and displayed a higher VF/SF correlation (r = 0.768) than the foot-to-foot (r = 0.425) and hand-to-foot (r = 0.497) current paths.

  16. Application of bioelectrical impedance vector analysis (BIVA in dogs: a preliminary study on gender-related differences

    Directory of Open Access Journals (Sweden)

    Rebecca Ricci

    2010-01-01

    Full Text Available In this preliminary study, BIVA has been performed on 17 healthy Italian Hound dogs, 10 males (M and 7 females (F, in order to verify if gender-related differences can be detected. Only in F higher reactance (Xc values (F: 46.4 vs M: 37.7, P<0.05 and a significant negative correlation (-0.80, P<0.05 between BCS and resistance (R values were detected. 50%, 75% and 95% tolerance ellipses were calculated both in M and F using average Xc and R values standardized for withers height. Probably due to the low number of subjects used in the present study, the variability of the individual vector distribution (F: 79.6 vs M: 53.0Ohm/m, as well as the mean impedance vector lengtht (F: 548.2 vs M: 498.9Ohm/m, were similar in F and M. The gender-related difference in phase angle values was not significant (F: 0.168 vs M: 0.157, P=ns. In conclusion, the use of BIVA in dogs indicated differences between males and females which should be confirmed by a larger number of subjects.

  17. Endogenous bioelectric ifelds:a putative regulator of wound repair and regeneration in the central nervous system

    Institute of Scientific and Technical Information of China (English)

    Matthew L.Baer; Raymond J.Colello

    2016-01-01

    Studies on a variety of highly regenerative tissues, including the central nervous system (CNS) in non-mammalian vertebrates, have consistently demonstrated that tissue damage induces the formation of an ionic current at the site of injury. These injury currents generate electric ifelds (EF) that are 100-fold increased in intensity over that measured for uninjured tissue.In vitro and in vivo experiments have con-vincingly demonstrated that these electric ifelds (by their orientation, intensity and duration) can drive the migration, proliferation and differentiation of a host of cell types. These cellular behaviors are all necessary to facilitate regeneration as blocking these EFs at the site of injury inhibits tissue repair while enhancing their intensity promotes repair. Consequently, injury-induced currents, and the EFs they produce, represent a potent and crucial signal to drive tissue regeneration and repair. In this review, we will discuss how injury currents are generated, how cells detect these currents and what cellular responses they can induce. Addi-tionally, we will describe the growing evidence suggesting that EFs play a key role in regulating the cellular response to injury and may be a therapeutic target for inducing regeneration in the mammalian CNS.

  18. Mechanisms of Bioelectricity Generation in Enterobacter Aerogenes-Based Microbial Fuel Cells%产气肠杆菌燃料电池产电机制研究

    Institute of Scientific and Technical Information of China (English)

    张锦涛; 周顺桂; 张礼霞; 卢娜; 邓丽芳; 倪晋仁

    2009-01-01

    基于铁还原菌的微生物燃料电池(MFCs)与基于产氢细菌的MFCs各有优劣,前者能量利用效率高,但底物利用范围有限;后者底物利用广泛,但其依靠悬浮细胞产电,电子回收率较低.本研究以1株具有铁还原活性的产氢菌Enterobacter aerogenes XM02为产电微生物,构建了3种不同阳极材料的空气阴极MFCs,通过输出电压和库仑效率的比较以及扫描电镜观察阳极形貌等方法对此菌的产电机制进行探讨.结果发现,采用比表面积大且具有氢催化活性的碳毡作为阳极材料时,可显著改善MFCs性能,库仑效率由载铂碳纸阳极MFC的1.68% 提高至42.49%,远高于已报道的其它产氢菌燃料电池.扫描电镜证实大量细菌细胞附着在阳极表面,形成阳极生物膜.采用非生长基质实验排除悬浮细胞的产电作用,证明附着在阳极的生物膜对产电起主导作用,认为生物膜原位产氢-氧化是此菌的主要产电机制.

  19. Electrochemical characteriztion of the bioanode during simultaneous azo dye decolorization and bioelectricity generation in an air-cathode single chambered microbial fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Sun Jian, E-mail: sunjian472@163.com [Ministry of Education Key Laboratory of Pollution Control and Ecological Remediation for Industrial Agglomeration Area, College of Environmental Science and Engineering, South China University of Technology, Guangzhou 510006 (China) and State Key Lab of Pulp and Paper Engineering, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640 (China); Hu Yongyou, E-mail: ppyyhu@scut.edu.cn [Ministry of Education Key Laboratory of Pollution Control and Ecological Remediation for Industrial Agglomeration Area, College of Environmental Science and Engineering, South China University of Technology, Guangzhou 510006 (China); State Key Lab of Pulp and Paper Engineering, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640 (China); Hou Bin, E-mail: houbin566@163.com [Ministry of Education Key Laboratory of Pollution Control and Ecological Remediation for Industrial Agglomeration Area, College of Environmental Science and Engineering, South China University of Technology, Guangzhou 510006 (China)

    2011-07-30

    To achieve high power output based on simultaneously azo dye decolorization using microbial fuel cell (MFC), the bioanode responses during decolorization of a representative azo dye, Congo red, were investigated in an air-cathode single chambered MFC using representative electrochemical techniques. It has been found that the maximum stable voltage output was delayed due to slowly developed anode potential during Congo red decolorization, indicating that the electrons recovered from co-substrate are preferentially transferred to Congo red rather than the bioanode of the MFC and Congo red decolorization is prior to electricity generation. Addition of Congo red had a negligible effect on the Ohmic resistance (R{sub ohm}) of the bioanode, but the charge-transfer resistance (R{sub c}) and the diffusion resistance (R{sub d}) were significantly influenced. The R{sub c} and R{sub d} firstly decreased then increased with increase of Congo red concentration, probably due to the fact that the Congo red and its decolorization products can act as electron shuttle for conveniently electrons transfer from bacteria to the anode at low concentration, but result in accelerated consumption of electrons at high concentration. Cyclic voltammetry results suggested that Congo red was a more favorable electron acceptor than the bioanode of the MFC. Congo red decolorization did not result in a noticeable decrease in peak catalytic current until Congo red concentration up to 900 mg l{sup -1}. Long-term decolorization of Congo red resulted in change in catalytic active site of anode biofilm.

  20. Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss

    DEFF Research Database (Denmark)

    Hendel, H W; Gotfredsen, A; Højgaard, L

    1996-01-01

    A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK). These measu......A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK...

  1. Multi-frequency bioelectrical impedance: a comparison between the Cole-Cole modelling and Hanai equations with the classical impedance index approach.

    Science.gov (United States)

    Deurenberg, P; Andreoli, A; de Lorenzo, A

    1996-01-01

    Total body water and extracellular water were measured by deuterium oxide and bromide dilution respectively in 23 healthy males and 25 healthy females. In addition, total body impedance was measured at 17 frequencies, ranging from 1 kHz to 1350 kHz. Modelling programs were used to extrapolate impedance values to frequency zero (extracellular resistance) and frequency infinity (total body water resistance). Impedance indexes (height2/Zf) were computed at all 17 frequencies. The estimation errors of extracellular resistance and total body water resistance were 1% and 3%, respectively. Impedance and impedance index at low frequency were correlated with extracellular water, independent of the amount of total body water. Total body water showed the greatest correlation with impedance and impedance index at high frequencies. Extrapolated impedance values did not show a higher correlation compared to measured values. Prediction formulas from the literature applied to fixed frequencies showed the best mean and individual predictions for both extracellular water and total body water. It is concluded that, at least in healthy individuals with normal body water distribution, modelling impedance data has no advantage over impedance values measured at fixed frequencies, probably due to estimation errors in the modelled data.

  2. Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss

    DEFF Research Database (Denmark)

    Hendel, H W; Gotfredsen, A; Højgaard, L;

    1996-01-01

    ). These measurements were compared with bioimpedance analysis (BIA) by applying 11 predictive BIA equations published in the literature. Predictive equations for the present study population were developed, with the use of fat-free mass (FFM) as assessed by TBK and DXA as references in multiple regression analysis...

  3. Bioelectrical impedance for detecting and monitoring lymphedema in patients with breast cancer. Preliminary results of the florence nightingale breast study group.

    Science.gov (United States)

    Erdogan Iyigun, Zeynep; Selamoglu, Derya; Alco, Gul; Pilancı, Kezban Nur; Ordu, Cetin; Agacayak, Filiz; Elbüken, Filiz; Bozdogan, Atilla; Ilgun, Serkan; Guler Uysal, Fusun; Ozmen, Vahit

    2015-03-01

    The aim of this study was to evaluate the efficacy of bioimpedance spectroscopy for the follow-up of patients with lymphedema in Turkey and its benefits in the diagnosis of stage 0, 1, and 2 lymphedema in patients who are under treatment for breast cancer. Thirty-seven female patients with breast cancer who underwent surgical procedures in our Breast Health Centre were followed up for lymphedema using bioimpedance, and clinical measurements were taken for a minimum period of 1 year at 3-month intervals. Patients who had been monitored regularly between November, 2011, and September, 2013, were enrolled to the study. In total, 8 patients developed lymphedema with an overall rate of 21.6%. Among the 8 patients who developed lymphedema, 4 had Stage 2, 1 had Stage 1, and 3 had Stage 0 lymphedema. Stage 0 lymphedema could not be detected with clinical measurements. During the patients' 1-year follow-up period using measurements of bioimpedance, a statistically significant relationship was observed between the occurrence of lymphedema and the disease characteristics. including the number of the extracted and remaining lymph nodes and the region of radiotherapy (p=0.042, p=0.024, p=0.040). Bioimpedance analysis seems to be a practical and reliable method for the early diagnosis of lymphedema. It is believed that regular monitoring of patients in the high-risk group using bioimpedance analyses increases the ability to treat lymphedema.

  4. A comparison between handgrip strength, upper limb fat free mass by segmental bioelectrical impedance analysis (SBIA) and anthropometric measurements in young males

    Science.gov (United States)

    Gonzalez-Correa, C. H.; Caicedo-Eraso, J. C.; Varon-Serna, D. R.

    2013-04-01

    The mechanical function and size of a muscle may be closely linked. Handgrip strength (HGS) has been used as a predictor of functional performing. Anthropometric measurements have been made to estimate arm muscle area (AMA) and physical muscle mass volume of upper limb (ULMMV). Electrical volume estimation is possible by segmental BIA measurements of fat free mass (SBIA-FFM), mainly muscle-mass. Relationship among these variables is not well established. We aimed to determine if physical and electrical muscle mass estimations relate to each other and to what extent HGS is to be related to its size measured by both methods in normal or overweight young males. Regression analysis was used to determine association between these variables. Subjects showed a decreased HGS (65.5%), FFM, (85.5%) and AMA (74.5%). It was found an acceptable association between SBIA-FFM and AMA (r2 = 0.60) and poorer between physical and electrical volume (r2 = 0.55). However, a paired Student t-test and Bland and Altman plot showed that physical and electrical models were not interchangeable (ptanthropometric (r2 = 0.07) and electrical (r2 = 0.192) ULMMV showing that muscle mass quantity does not mean muscle strength. Other factors influencing HGS like physical training or nutrition require more research.

  5. Bioelectrical Impedance Frequency Spectrum Measurement System Based on Single Chip Computer%基于单片机的生物电阻抗频谱测量系统

    Institute of Scientific and Technical Information of China (English)

    罗仕强; 田华; 黄华

    2009-01-01

    测量生物材料幅频和相频特性是研究生物组织电性质的重要方法,同时测量系统的精度决定研究结果的准确性.针对此项研究,测量系统以C8051F340单片机为MCU;AD9852为信号源,产生频率、幅度可调的正弦信号.采用AD8302测量组织与标准电阻两端的幅度比和相位差,实现1 Hz~10 MHz频率范围内测量生物组织的频谱特性.实验结果表明,该系统实时性和精确度较好.

  6. Bioelectrical impedance and visceral fat: a comparison with computed tomography in adults and elderly; Bioimpedancia eletrica e gordura visceral: uma comparacao com a tomografia computadorizada em adultos e idosos

    Energy Technology Data Exchange (ETDEWEB)

    Eickemberg, Michaela [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil); Roriz, Anna Karla Carneiro [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil); Fontes, Gardenia Abreu Vieira [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil); Sampaio, Lilian Ramos [Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP (Brazil)

    2013-05-01

    Objective: To evaluate the association between electrical bioimpedance analysis (BIA) and visceral fat (VF) in adult and elderly patients. Subjects and methods: This was a cross-sectional study, with a sample of 191 subjects (52% women, 49% elderly) stratified by sex, age and body mass. Computerized tomography (VF area) and BIA (percentage of total body fat (%TBF-BIA), phase angle, reactance and resistance) data were generated. Statistical analysis was based on Pearson's Correlation Coefficient, Anova, Pearson's Chi-square, and ROC curves. Results: VF areas {>=} 130 cm{sup 2} were more prevalent among the elderly and among men. Adult females showed a stronger correlation between GV and %TBF-BIA. The other groups showed similar results and statistically significant correlations. Correlations between GV and phase angle were weak and not statistically significant. ROC Curves analyzes showed the following %TBF-BIA, which identified excess VF: for male subjects: 21.5% (adults) and 24.25% (elderly); for female subjects: 35.05% (adults) and 38.45% (elderly) with sensitivity of 78.6%, 82.1%, 83.3%, and 66.7%, and specificity of 70.6%, 62.5%, 79.1%, and 69%, respectively. Conclusion: BIA was found to have satisfactory sensitivity and specificity to predict VF; however, other devices and other techniques should be investigated to improve VF prediction. (author)

  7. A study of promoting regeneration of peripheral nerve with simulated bioelectrical impulse of phrenic nerve%模拟膈神经脉冲电刺激促进周围神经再生的研究

    Institute of Scientific and Technical Information of China (English)

    夏奕俊; 徐向阳; 崔茂龙; 王成

    2004-01-01

    目的研究膈神经生物电脉冲(BIPN)对周围神经再生的促进作用.方法新西兰家兔18只平均分为3组,切断双侧坐骨神经后端端缝合予以电刺激.A组以BIPN刺激与无刺激对照;B组以BIPN刺激与方波脉冲刺激对照;C组以方波脉冲刺激与无刺激对照.刺激4周后行足底溃疡直径、神经电生理、胫前肌肌湿重、组织学和电镜超微结构检测.结果A、B组BIPN侧足底溃疡直径分别为(16.33±17.17) mm和(22.33±7.50) mm,均优于对照侧(P<0.01,P<0.05);复合肌肉诱发电位(CMAP)潜伏期分别为(1.98±0.20) ms和(1.92±0.16) ms,均优于对照侧(P<0.05);A组CMAP波幅为(0.18±0.07) mV,优于对照侧(P<0.05);远端有髓纤维通过率分别为(62.44±6.68)%和(54.48±5.05)%,均优于对照侧(P<0.01);胫前肌肌湿重分别为(1.67±0.24)g和(1.71±0.25)g,均优于对照侧(P<0.01);超微结构观察示BIPN侧再生髓鞘成熟度优于方波脉冲侧,更优于无刺激侧.结论膈神经电脉冲能较明显地促进周围神经再生.

  8. A comparison of dual energy x-ray absorptiometry and two bioelectrical impedance analyzers to measure body fat percentage and fat-free mass index in a group of Mexican young women.

    Science.gov (United States)

    Velazquez-Alva, Maria Del Consuelo; Irigoyen-Camacho, Maria Esther; Huerta-Huerta, Raquel; Delgadillo-Velazquez, Jaime

    2014-05-01

    Introducción: Los estudios de obesidad requieren estimación de masa grasa (FM) y masa libre de grasa (FFM). Objetivo: Comparar dos equipos de impedancia bioeléctrica (BIA) para estimar FM y FFM usando absorciometría de rayos X de energía dual (DXA) como referencia. Métodos: Estudio transversal. FM y FFM fueron evaluados por DXA y BIA: sistema pie-pie (FFS) y sistema mano-pie (HFS). Se realizaron pruebas t pareadas, coeficientes de correlación y análisis de Bland y Altman. Limites de acuerdo fueron calculados (CL). Resultados: Fueron estudiadas 175 mujeres (22,9 ± 2,2 años). Hubo diferencias significativas entre el promedio del porcentaje de grasa estimado por los equipos de BIA en comparación con DXA (FFS = 28,7%, HFS = 34,4% y DXA = 35,3%). La diferencia de medias del porcentaje de grasa entre HFS y DXA fue -0.96, (CL -5,29, 7,21). La diferencia de medias para FFS fue de -6,69,(CL -0,29, - 13.09) Hubo diferencias significativas entre las estimaciones de FFMI por BIA y DXA (FFS = 16,29, HFS = 14,95, DXA = 14,18). La diferencia de medias entre HFS y DXA fue = 0,78, (CL -2,27, 0,72) y la diferencia de medias de FFS fue -2,11: (CL -3,73 , -0,49). Conclusiones: Niveles diferentes de sesgo se observaron entre los equipos de BIA. El HFS parece ser más confiable que el FFS, sobre todo en la obtención de FFMI en mujeres jóvenes.

  9. From Neural Plate to Cortical Arousal—A Neuronal Network Theory of Sleep Derived from in Vitro “Model” Systems for Primordial Patterns of Spontaneous Bioelectric Activity in the Vertebrate Central Nervous System

    Directory of Open Access Journals (Sweden)

    Michael A. Corner

    2013-05-01

    Full Text Available In the early 1960s intrinsically generated widespread neuronal discharges were discovered to be the basis for the earliest motor behavior throughout the animal kingdom. The pattern generating system is in fact programmed into the developing nervous system, in a regionally specific manner, already at the early neural plate stage. Such rhythmically modulated phasic bursts were next discovered to be a general feature of developing neural networks and, largely on the basis of experimental interventions in cultured neural tissues, to contribute significantly to their morpho-physiological maturation. In particular, the level of spontaneous synchronized bursting is homeostatically regulated, and has the effect of constraining the development of excessive network excitability. After birth or hatching, this “slow-wave” activity pattern becomes sporadically suppressed in favor of sensory oriented “waking” behaviors better adapted to dealing with environmental contingencies. It nevertheless reappears periodically as “sleep” at several species-specific points in the diurnal/nocturnal cycle. Although this “default” behavior pattern evolves with development, its essential features are preserved throughout the life cycle, and are based upon a few simple mechanisms which can be both experimentally demonstrated and simulated by computer modeling. In contrast, a late onto- and phylogenetic aspect of sleep, viz., the intermittent “paradoxical” activation of the forebrain so as to mimic waking activity, is much less well understood as regards its contribution to brain development. Some recent findings dealing with this question by means of cholinergically induced “aroused” firing patterns in developing neocortical cell cultures, followed by quantitative electrophysiological assays of immediate and longterm sequelae, will be discussed in connection with their putative implications for sleep ontogeny.

  10. From neural plate to cortical arousal-a neuronal network theory of sleep derived from in vitro "model" systems for primordial patterns of spontaneous bioelectric activity in the vertebrate central nervous system.

    Science.gov (United States)

    Corner, Michael A

    2013-05-22

    In the early 1960s intrinsically generated widespread neuronal discharges were discovered to be the basis for the earliest motor behavior throughout the animal kingdom. The pattern generating system is in fact programmed into the developing nervous system, in a regionally specific manner, already at the early neural plate stage. Such rhythmically modulated phasic bursts were next discovered to be a general feature of developing neural networks and, largely on the basis of experimental interventions in cultured neural tissues, to contribute significantly to their morpho-physiological maturation. In particular, the level of spontaneous synchronized bursting is homeostatically regulated, and has the effect of constraining the development of excessive network excitability. After birth or hatching, this "slow-wave" activity pattern becomes sporadically suppressed in favor of sensory oriented "waking" behaviors better adapted to dealing with environmental contingencies. It nevertheless reappears periodically as "sleep" at several species-specific points in the diurnal/nocturnal cycle. Although this "default" behavior pattern evolves with development, its essential features are preserved throughout the life cycle, and are based upon a few simple mechanisms which can be both experimentally demonstrated and simulated by computer modeling. In contrast, a late onto- and phylogenetic aspect of sleep, viz., the intermittent "paradoxical" activation of the forebrain so as to mimic waking activity, is much less well understood as regards its contribution to brain development. Some recent findings dealing with this question by means of cholinergically induced "aroused" firing patterns in developing neocortical cell cultures, followed by quantitative electrophysiological assays of immediate and longterm sequelae, will be discussed in connection with their putative implications for sleep ontogeny.

  11. Research of CMOS Integrated Biosensor for Extracellular Bioelectrical Signal Recording%用于细胞外电信号测量的CMOS集成生物传感芯片的研究

    Institute of Scientific and Technical Information of China (English)

    朱婷; 朱大中

    2006-01-01

    新型的细胞外电信号传感芯片是采用0.6 μm标准CMOS工艺设计制造,片上集成了6×6单元有源传感阵列、模拟多路选择器、输出缓冲器、参考源和数字控制电路.有源传感单元面积为60μm×60μm,包含15μm×15μm的传感电极和预处理电路,能够线性放大幅值范围100μV~25 mV的微小信号,电压增益为40dB.并采用相关二次采样工作模式降低固定模式噪声,提高传感器的精度.在标准CMOS工艺基础上,应用无电浸镀金改进传感电极的生物兼容性,并采用特殊封装技术提高芯片在溶液环境中的稳定性.溶液中模拟生物信号测量验证了该芯片的功能.%A new CMOS (complementary metal oxide silicon) biosensor chip designed for recording electrophysiological activities of in-vitro cultured cells is reported. It is designed and fabricated in a standard 0.6μm CMOS process, consisting of 6×6 active sensor array, analog multiplexer, output buffers, reference sources and digital controlling circuit. Each sensor cell is 60μm× 60μm in the dimension, including a 15μm×15μm electrode and a pre-processing circuit which could linearly amplify signals with peak-to-peak values from 100μV to 25 mV. The correlated double sampling circuit is utilized to remove the common-mode noise. Post-CMOS processes including electroless gold plating and special package technique are implemented to enhance the biocompatibility and stability of the biosensor. The tests carried out in the solution have verified the electrical functionality of the biosensor chip.

  12. Bioelectric and Morphological Response of Liquid-Covered Human Airway Epithelial Calu-3 Cell Monolayer to Periodic Deposition of Colloidal 3-Mercaptopropionic-Acid Coated CdSe-CdS/ZnS Core-Multishell Quantum Dots.

    Directory of Open Access Journals (Sweden)

    Aizat Turdalieva

    Full Text Available Lung epithelial cells are extensively exposed to nanoparticles present in the modern urban environment. Nanoparticles, including colloidal quantum dots (QDs, are also considered to be potentially useful carriers for the delivery of drugs into the body. It is therefore important to understand the ways of distribution and the effects of the various types of nanoparticles in the lung epithelium. We use a model system of liquid-covered human airway epithelial Calu-3 cell cultures to study the immediate and long-term effects of repeated deposition of colloidal 3-mercaptopropionic-acid coated CdSe-CdS/ZnS core-multishell QDs on the lung epithelial cell surface. By live confocal microscope imaging and by QD fluorescence measurements we show that the QD permeation through the mature epithelial monolayers is very limited. At the time of QD deposition, the transepithelial electrical resistance (TEER of the epithelial monolayers transiently decreased, with the decrement being proportional to the QD dose. Repeated QD deposition, once every six days for two months, lead to accumulation of only small amounts of the QDs in the cell monolayer. However, it did not induce any noticeable changes in the long-term TEER and the molecular morphology of the cells. The colloidal 3-mercaptopropionic-acid coated CdSe-CdS/ZnS core-multishell QDs could therefore be potentially used for the delivery of drugs intended for the surface of the lung epithelia during limited treatment periods.

  13. 基于生物电阻抗的血型检测新方法及系统实现%New Method for Blood Type Detection Based on Bioelectrical lmpedance Analysis Technology and its System lmplementation

    Institute of Scientific and Technical Information of China (English)

    陈里里; 廖强; 胡雪; 张国珍

    2014-01-01

    A new method for blood type detection and a new automated blood typing system are developed. In the system,the combined use of the AD9850 chip and MCU are employed to realize the DDS technique and produce excitation signal. Then an elliptic filter is designed to eliminate the signal interference,and an amplitude stabilized circuit is designed to stabilize the amplitude of the signal output by using an AD8370 chip,which is a low-cost variable gain amplifier. The amplitude and phase measurement chip AD8302 is adopted to extract the impedance information. Based on neural network recognition model,a new method is designed to determine the degree of agglutination in red blood cell suspension. The use of this method combined with the discriminant rule could successfully identify the blood type. Contrastive test is carried out and the new system showed high measurement accuracy and good stability,could better distinguish the different intensity of agglutination in red blood cell,and identified ABO and Rh blood type correctly in normal samples. The self-developed new automated blood typing system is in better agreement with clinical requirements.%提出了基于生物电阻抗测量技术的血型检测新方法并研制了检测系统。该系统采用单片机结合AD9850芯片实现 DDS 技术产生激励信号,设计椭圆滤波器消除信号干扰;运用低成本放大器 AD8370设计稳幅电路,确保信号输出幅度不变;系统采用 AD8302幅相检测芯片实现阻抗信息提取;基于人工神经网络判别红细胞悬浮液凝集强度,并结合判别规则得到血型结果。测试结果表明该系统精度高,稳定性好;临床实验表明,该系统能正确识别红细胞6种不同凝集程度,能100%正确地检测出正常标本的 ABO 和 Rh 血型,可更好地满足临床需求。

  14. Energy balance, bioelectricity and emission of greenhouse gases from power plants in Mato Grosso do Sul; Balanco energetico, bioeletricidade e emissao de gases estufa das usinas de Mato Grosso do Sul

    Energy Technology Data Exchange (ETDEWEB)

    Turdera, Eduardo Mirko Valenzuela [Universidade Federal da Grande Dourados (UFGD), MS (Brazil)], email: eduardoturdera@ufgd.edu.br

    2010-07-01

    First we present in this paper the most important greenhouse gases emitted by sugar cane crops. The principal reference of the energy balance methodology and its theory are described. Furthermore, we show the yields of the unique energy balance applied to the sugar cane mills of Mato Grosso do Sul. The yields brings information about land use of the sugar cane crops, efficiency of technologies and process to produce ethanol and inputs about how the companies could improve its competitive position which involves, to care of environment impacts. Finally, we present the yield of CO{sub 2} emissions of the five mills evaluated. (author)

  15. Correlation between birth weight and maternal body composition.

    LENUS (Irish Health Repository)

    Kent, Etaoin

    2013-01-01

    To estimate which maternal body composition parameters measured using multifrequency segmental bioelectric impedance analysis in the first trimester of pregnancy are predictors of increased birth weight.

  16. Flora Luma

    DEFF Research Database (Denmark)

    Frankjær, Raune; Kitel, Maggie

    2016-01-01

    Flora Luma is a plant controlled installation which detects the bioelectrical signals emitted from plants and displays them as animated light on freestanding amorphous objects.......Flora Luma is a plant controlled installation which detects the bioelectrical signals emitted from plants and displays them as animated light on freestanding amorphous objects....

  17. Economic impacts of bio-refinery and resource cascading systems: an applied general equilibrium analysis for Poland.

    Science.gov (United States)

    Ignaciuk, Adriana M; Sanders, Johan

    2007-12-01

    Due to more stringent energy and climate policies, it is expected that many traditional chemicals will be replaced by their biomass-based substitutes, bio-chemicals. These innovations, however, can influence land allocation since the demand for land dedicated to specific crops might increase. Moreover, it can have an influence on traditional agricultural production. In this paper, we use an applied general equilibrium framework, in which we include two different bio-refinery processes and incorporate so-called cascading mechanisms. The bio-refinery processes use grass, as one of the major inputs, to produce bio-nylon and propane-diol (1,3PDO) to substitute currently produced fossil fuel-based nylon and ethane-diol. We examine the impact of specific climate policies on the bioelectricity share in total electricity production, land allocation, and production quantities and prices of selected commodities. The novel technologies become competitive, with an increased stringency of climate policies. This switch, however, does not induce a higher share of bioelectricity. The cascade does stimulate the production of bioelectricity, but it induces more of a shift in inputs in the bioelectricity sector (from biomass to the cascaded bio-nylon and 1, 3PDO) than an increase in production level of bioelectricity. We conclude that dedicated biomass crops will remain the main option for bioelectricity production: the contribution of the biomass systems remains limited. Moreover, the bioelectricity sector looses a competition for land for biomass production with bio-refineries.

  18. Investigation of the Surrounding Environment's Influence on Gait Sensing Using a Plant as a Sensor

    Directory of Open Access Journals (Sweden)

    Shigeki Hirobayashi

    2009-01-01

    In addition, we monitored the effect of a person walking on the spot near the plant on the bioelectric potential of the plant. Six subjects stepped on the spot 50 cm from a rubber tree and we measured the variation in the bioelectric potential of the tree produced by this stepping motion. The results confirmed that stepping motion produces a measurable response in the bioelectric potential of a plant and that this response varies in synchrony with the subject's stepping rate. Moreover, by conducting principal component analysis using the peak value of the spectrum characteristics of the measured bioelectric potential, cumulative proportion was found to reach nearly 97% at low-frequency components up to the fifth peak.

  19. Medicinsk Elektronik

    DEFF Research Database (Denmark)

    Andersen, Ole Trier

    1998-01-01

    Lecture noter for the course in Medical Electronics covering the following topics: Nerve and muscle physiology; bioelectrical signal amplification and recording; blood pressure and flow measurements; cardiology; medical applications of ultrasound; medical imaging methods: CT, MR, SPECT, and PET...

  20. Analysis of the sodium recirculation theory of solute-coupled water transport in small intestine

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Sørensen, Jakob Balslev; Sørensen, Jens Nørkaer

    2002-01-01

    permeabilities and pump constants of fluxes of water and electrolytes, volumes and ion concentrations of cell and lateral intercellular space (lis), and membrane potentials and conductances. Simulating physiological bioelectrical features together with cellular and paracellular fluxes of the sodium ion...

  1. Finite element simulations of magnetomyograms of rat skeletal muscle

    NARCIS (Netherlands)

    Rutten, W.L.C.; Wildeman, A.; Rozijn, T.H.

    1990-01-01

    The following topics are dealt with: biosensors; cardiology; processing of bioelectric signals; biomedical application of automatic control; lasers and electrooptics; computers in medicine; expert systems in medicine; fractals in biomedical engineering; neural networks; biophysical and biochemical m

  2. 空气置换法、生物电阻抗法与皮褶厚度法测试身体成分的比较研究%Comparative Study of Air Displacement Plethysmography, Bioelectrical Impedance Analysis and Skinfold Thickness in the Determination of Adult Body Fat Percentage

    Institute of Scientific and Technical Information of China (English)

    金晶; 庄洁; 陈佩杰; 王人卫

    2008-01-01

    目的:探讨生物电阻抗法与皮褶厚度法测定身体成分的结果与空气置换法(BOD-POD)结果的相关性.方法:随机选取20~59岁上海市居民697名(男471名,女226名),以空气置换法测定的身体成分值作为标准,将生物电阻抗法(OMRON与TANITA)和皮褶厚度法(测量部位为上臂部和肩胛部)的结果与之进行单因素方差分析和相关性分析.结果:皮褶厚度法测试结果与空气置换法结果相关性最低;生物电阻抗法中,TANITA测试结果与空气置换法结果相关性最高,OMRON相关性较低.结果提示:生物电阻抗法中TANI-TA测量的可靠性相对较高,皮褶厚度法(测量部位为上臂部和肩胛部)测量的可靠性相对较低.

  3. Comparison of bioelectrical impedance with skinfold thickness and X-ray absorptiometry to measure body composition in HIV-infected with lipodistrophy Comparación de impendancia bioeléctrica con grosor de pliegues cutáneos y absorciometría de rayos X para mensurar la composición corporal de personas con VIH con lipodistrofia

    OpenAIRE

    H. Siqueira Vassimon; JORDAO, A. A.; F. J. Albuquerque de Paula; A. Artioli Machado; J. Pontes Monteiro

    2011-01-01

    Introduction: Human immunodeficiency vírus (HIV)-associated lipodystrophy syndrome (LS) includes body composition and metabolic alterations. Lack of validated criteria and tools make difficult to evaluate body composition in this group. Objective: The aim of the study was to compare different methods to evaluate body composition between Brazilians HIV subjects with (HIV+LIPO+) or without LS (HIV+LIPO-) and healthy subjects (Control). Methods: in a cross-sectional analyses, body composition wa...

  4. Reactivity of the EEG characteristics in teenagers with varying degrees of HRV biofeedback training success

    Directory of Open Access Journals (Sweden)

    D. B. Dyomin

    2012-01-01

    Full Text Available We consider the nature of the brain bioelectric activity changes in the dynamics of heart rate variability parameters biofeedback sessions in teenagers. There was revealed increase in predominance of the brain functional activity and increase in the stability of the subcortical brain structures. The biggest bioelectric reorganizations are revealed in the right brain hemisphere, often involving the frontal brain lobes. These changes were more pronounced in adolescents with successful completion of training.

  5. Putting it all on pigmentation: Heuristics of a bold and stochastic cell fate decision.

    Science.gov (United States)

    Xing, Jianhua; Lee, Robin E C

    2015-10-06

    Gradients of transmembrane potential coordinate cell-fate decisions and patterning during embryogenesis and wound-healing. Bioelectrical signaling may also be more important for adult pathologies than currently recognized. In this issue of Science Signaling, Lobikin et al. describe a role for bioelectric signals during the development of Xenopus leavis embryos to instruct an organism-level response reminiscent of neoplastic progression in melanoma.

  6. Anthropometric methods for obesity screening in schoolchildren; the Ouro Preto Study.

    OpenAIRE

    Cândido, Ana Paula Carlos; J. P. S. Alosta; C.T. Oliveira; Freitas, Renata Nascimento de; Freitas, Silvia Nascimento de; Coelho, George Luiz Lins Machado

    2012-01-01

    Background and aims: Childhood obesity is increasing dramatically in last decades. To evaluate the usefulness of body mass index (BMI), skinfold thickness (ST), waist circumference (WC), and foot-to-foot bioelectrical impe - dance (BIA-FF) for screening for obesity in mixed-race population, using the tetrapolar bioelectrical impedance (BIA-T) technique as reference method. Methods and results: A cross-sectional-based population study was performed in the city of Ouro Preto, Brazil, in 2006. S...

  7. Diseño e implementación de un sistema modular y configurable para la captación de distintas señales bioeléctricas

    OpenAIRE

    TERRES HARO, JOSE MANUEL

    2016-01-01

    Nowadays the study and acquisition of bioelectric signalshas wide applicability in the field of medical diagnosis. In the course of Bioelectronic of the Degree in Electronic and Automation Engineering, the students design and develop in a PC board conditioning systems for different bioelectric signals, such as electrocardiogram, electromyogram, electrooculogram and electrogastrogram. It has identified the need for a modular and configurable system that allows students to check their designs...

  8. EEG CHARACTERISTICS AND THYROID PROFILE RATIO IN ADOLESCENTS OF SUBPOLAR AND POLAR EUROPEAN NORTH AREAS

    Directory of Open Access Journals (Sweden)

    D. B. Demin

    2013-01-01

    Full Text Available Features of brain bioelectric activity and thyroid system in adolescents living in Subpolar andPolar regionsof the North are considered. Hyperactivity of subcortical diencephalic brain structures in adolescents of the Polar region is revealed. Adolescents of Subpolar region have more intensive age optimization of neurodynamic processes. There are noted latitude distinctions of thyroid hormones role for age formation of brain bioelectric activity in adolescents.

  9. Barrier Functionality of Porcine and Bovine Brain Capillary Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Ailar Nakhlband

    2011-09-01

    Full Text Available Introduction: To date, isolated cell based blood-brain barrier (BBB models have been widely used for brain drug delivery and targeting, due to their relatively proper bioelectrical and permeability properties. However, primary cultures of brain capillary endothelial cells (BCECs isolated from different species vary in terms of bioelectrical and permeability properties. Methods: To pursue this, in the current investigation, primary porcine and bovine BCECs (PBCECs and BBCECs, respectively were isolated and used as an in vitro BBB model. The bioelectrical and permeability properties were assessed in BCECs co-cultured with C6 cells with/without hydrocortisone (550 nM. The bioelectrical properties were further validated by means of the permeability coefficients of transcellular and paracellular markers. Results: The primary PBCECs displayed significantly higher trans-endothelial electrical resistance (~900 W.cm2 than BBCECs (~700 W.cm2 - both co-cultured with C6 cells in presence of hydrocortisone. Permeability coefficients of propranolol/diazepam and mannitol/sucrose in PBCECs were ~21 and ~2 (×10-6 cm.sec-1, where these values for BBCECs were ~25 and ~5 (×10-6 cm.sec-1. Conclusion: Upon our bioelectrical and permeability findings, both models display discriminative barrier functionality but porcine BCECs seem to provide a better platform than bovine BCECs for drug screening and brain targeting.

  10. A Radio Frequency Electric Current Enhances Antibiotic Efficacy against Bacterial Biofilms

    Science.gov (United States)

    Caubet, R.; Pedarros-Caubet, F.; Chu, M.; Freye, E.; de Belém Rodrigues, M.; Moreau, J. M.; Ellison, W. J.

    2004-01-01

    Bacterial biofilms are notably resistant to antibiotic prophylaxis. The concentration of antibiotic necessary to significantly reduce the number of bacteria in the biofilm matrix can be several hundred times the MIC for the same bacteria in a planktonic phase. It has been observed that the addition of a weak continuous direct electric current to the liquid surrounding the biofilm can dramatically increase the efficacy of the antibiotic. This phenomenon, known as the bioelectric effect, has only been partially elucidated, and it is not certain that the electrical parameters are optimal. We confirm here the bioelectric effect for Escherichia coli biofilms treated with gentamicin and with oxytetracycline, and we report a new bioelectric effect with a radio frequency alternating electric current (10 MHz) instead of the usual direct current. None of the proposed explanations (transport of ions within the biofilm, production of additional biocides by electrolysis, etc.) of the direct current bioelectric effect are applicable to the radio frequency bioelectric effect. We suggest that this new phenomenon may be due to a specific action of the radio frequency electromagnetic field upon the polar parts of the molecules forming the biofilm matrix. PMID:15561841

  11. Validation and aplication of Bioelectrical Impedance (BIA) method to determine body and carcass composition and nutrient retention of growing rabbits = Validación y aplicación de la técnica de la Impedancia Bioeléctrica (BIA) para determinar la composición corporal, de la canal y la retención de nutrientes de conejos en crecimiento

    OpenAIRE

    Saiz del Barrio, Alejandro

    2016-01-01

    Los objetivos de esta tesis fueron 1) obtener y validar ecuaciones de predicción para determinar in vivo la composición corporal y de la canal de conejos en crecimiento de 25 a 77 días de vida utilizando la técnica de la Impedancia Bioeléctrica (BIA), y 2) evaluar su aplicación para determinar diferencias en la composición corporal y de la canal, así como la retención de nutrientes de animales alimentados con diferentes fuentes y niveles de grasa. El primer estudio se realizó para determinar...

  12. VALIDITY OF BODY DENSITY WITH METHODS OF BODY MASS INDEX, SKIN FOLD, BIO- ELECTRICAL IMPEDANCE & CRITERION METHOD OF HYDROSTATIC IN MEN ATHLETES OF SWIMMING

    Directory of Open Access Journals (Sweden)

    M Bayat KASHKOLİ

    2011-12-01

    Full Text Available The goal of present research is estimating and validity of body density with methods of Body Mass Index, Skin Fold, Bio-Electrical Impedance and Criterion Method of Hydrostatic in men athletes of swimming. The present research has been conducted with semi-experimental and functional method. For doing so 25 men swimming athletes were randomly selected (N= 120. Statistical analysis was conducted with Pearson coefficient, correlated T-test, TE & SEE. The results of statistical analysis show that the method of Skin Fold Stat with hydrostatic criterion method has meaningful difference in society of swimmers. Also there is meaningful difference between body mass index and criterion method. There was not any meaningful difference between bio-electrical impedance and criterion method in swimmers. (TE=3.01, SEE=2.91, R=0.924, P=0.064. The findings show that that bio-electrical impedance in swimmer athletes is more suitable method.

  13. Analysis and application of analog electronic circuits to biomedical instrumentation

    CERN Document Server

    Northrop, Robert B

    2012-01-01

    All chapters include an introduction and chapter summary.Sources and Properties of Biomedical SignalsSources of Endogenous Bioelectric SignalsNerve Action PotentialsMuscle Action PotentialsThe ElectrocardiogramOther BiopotentialsElectrical Properties of BioelectrodesExogenous Bioelectric SignalsProperties and Models of Semiconductor Devices Used in Analog Electronic Systemspn Junction DiodesMidfrequency Models for BJT BehaviorMidfrequency Models for Field-Effect TransistorsHigh-Frequency Models for Transistors and Simple Transistor AmplifiersPhotons, Photodiodes, Photoconductors, LEDs, and Las

  14. The Application of Biomedical Engineering Techniques to the Diagnosis and Management of Tropical Diseases: A Review

    Directory of Open Access Journals (Sweden)

    Fatimah Ibrahim

    2015-03-01

    Full Text Available This paper reviews a number of biomedical engineering approaches to help aid in the detection and treatment of tropical diseases such as dengue, malaria, cholera, schistosomiasis, lymphatic filariasis, ebola, leprosy, leishmaniasis, and American trypanosomiasis (Chagas. Many different forms of non-invasive approaches such as ultrasound, echocardiography and electrocardiography, bioelectrical impedance, optical detection, simplified and rapid serological tests such as lab-on-chip and micro-/nano-fluidic platforms and medical support systems such as artificial intelligence clinical support systems are discussed. The paper also reviewed the novel clinical diagnosis and management systems using artificial intelligence and bioelectrical impedance techniques for dengue clinical applications.

  15. The application of biomedical engineering techniques to the diagnosis and management of tropical diseases: a review.

    Science.gov (United States)

    Ibrahim, Fatimah; Thio, Tzer Hwai Gilbert; Faisal, Tarig; Neuman, Michael

    2015-03-23

    This paper reviews a number of biomedical engineering approaches to help aid in the detection and treatment of tropical diseases such as dengue, malaria, cholera, schistosomiasis, lymphatic filariasis, ebola, leprosy, leishmaniasis, and American trypanosomiasis (Chagas). Many different forms of non-invasive approaches such as ultrasound, echocardiography and electrocardiography, bioelectrical impedance, optical detection, simplified and rapid serological tests such as lab-on-chip and micro-/nano-fluidic platforms and medical support systems such as artificial intelligence clinical support systems are discussed. The paper also reviewed the novel clinical diagnosis and management systems using artificial intelligence and bioelectrical impedance techniques for dengue clinical applications.

  16. Wireless ultrasound-powered biotelemetry for implants.

    Science.gov (United States)

    Towe, Bruce C; Larson, Patrick J; Gulick, Daniel W

    2009-01-01

    A miniature piezoelectric receiver coupled to a diode is evaluated as a simple device for wireless transmission of bioelectric events to the body surface. The device converts the energy of a surface-applied ultrasound beam to a high frequency carrier current in solution. Bioelectrical currents near the implant modulate the carrier amplitude, and this signal is remotely detected and demodulated to recover the biopotential waveform. This technique achieves millivolt sensitivity in saline tank tests, and further attention to system design is expected to improve sensitivity.

  17. Mathematical modelling of light-induced electric reaction of Cucurbita pepo L. leaves

    Directory of Open Access Journals (Sweden)

    Jan Stolarek

    2014-01-01

    Full Text Available The bioelectRIc reactions of 14-16 day old plants of pumpkin (Cucurbita pepo L. and internodal cells of Nitellopsis obtusa to the action of visible and ultraviolet light (UV-C were studied. The possibility of analyzing the bioelectric reaction of pumpkin plants induced by visible light by means of mathematical modelling using a linear differential equation of the second order was considered. The solution of this equation (positive and negative functions can, in a sufficient way, reflect the participation of H+ and CI- ions in the generation of the photoelectric response in green plant cells.

  18. Adaptación de la tecnología de optimización del pH, potencial redox (rH2) y resistividad (r) de los fluidos corporales en tecnología de los alimentos

    OpenAIRE

    Cidón Madrigal, José Luis

    2005-01-01

    La alimentación es un factor esencial que compensa el esfuerzo del organismo por no desviarse de la normalidad en sus valores bioelectrónicos. Los datos objetivos indican que los alimentos en su estado original, muestran valores ácidos y reducidos; necesarios para contrarrestar los desequilibrios del terreno del cuerpo hacia la alcalosis y la oxidación, donde se desarrollan las enfermedades de la civilización. Con la bioelectrónica aplicada a los alimentos obtenemos valores reales del único m...

  19. On The Construction of Models for Electrical Conduction in Biological Tissues

    Science.gov (United States)

    Gómez-Aguilar, F.; Bernal-Alvarado, J.; Cordova-Fraga, T.; Rosales-García, J.; Guía-Calderón, M.

    2010-12-01

    Applying RC circuit theory, a theoretical representation for the electrical conduction in a biological multilayer system was developed. In particular an equivalent circuit for the epidermis, dermis and the subcutaneous tissue was constructed. This model includes an equivalent circuit, inside the dermis, in order to model a small formation like tumor. This work shows the feasibility to apply superficial electrodes to detect subcutaneous abnormalities. The behavior of the model is shown in the form of a frequency response chart. The Bode and Nyquist plots are also obtained. This theoretical frame is proposed to be a general treatment to describe the bioelectrical transport in a three layer bioelectrical system.

  20. The water footprint of biofuel-based transport

    NARCIS (Netherlands)

    Gerbens-Leenes, P.W.; Hoekstra, A.Y.

    2011-01-01

    The EU target to replace 10 percent of transport fuels by renewables by 2020 requires additional water. This study calculates water footprints (WFs) of transport modes using first generation bio-ethanol, biodiesel or bio-electricity and of European transport if 10 percent of transport fuels is bio-e

  1. Effect of influenza-induced fever on human bioimpedance values.

    Directory of Open Access Journals (Sweden)

    Elisabetta Marini

    Full Text Available Bioelectrical impedance analysis (BIA is a widely used technique to assess body composition and nutritional status. While bioelectrical values are affected by diverse variables, there has been little research on validation of BIA in acute illness, especially to understand prognostic significance. Here we report the use of BIA in acute febrile states induced by influenza.Bioimpedance studies were conducted during an H1N1 influenza A outbreak in Venezuelan Amerindian villages from the Amazonas. Measurements were performed on 52 subjects between 1 and 40 years of age, and 7 children were re-examined after starting Oseltamivir treatment. Bioelectrical Impedance Vector Analysis (BIVA and permutation tests were applied.For the entire sample, febrile individuals showed a tendency toward greater reactance (p=0.058 and phase angle (p=0.037 than afebrile individuals, while resistance and impedance were similar in the two groups. Individuals with repeated measurements showed significant differences in bioimpedance values associated with fever, including increased reactance (p<0.001 and phase angle (p=0.007, and decreased resistance (p=0.007 and impedance (p<0.001.There are bioelectrical variations induced by influenza that can be related to dehydration, with lower extracellular to intracellular water ratio in febrile individuals, or a direct thermal effect. Caution is recommended when interpreting bioimpedance results in febrile states.

  2. Reliability of non-lethal assessment methods of body composition and energetic status exemplified by applications to eel (Anguilla anguilla) and carp (Cyprinus carpio)

    DEFF Research Database (Denmark)

    Klefoth, Thomas; Skov, Christian; Aarestrup, Kim;

    2013-01-01

    ),bioelectric impedance-based assessments of body composition (BIA), and microwave-based “fat” meters(FM). Previous studies have revealed mixed findings as to the reliability of each of these. We compared theperformance of Kn, BIA and FM at different temperatures to predict energetic status of the whole bodiesof live eel...

  3. Obesity and Motor Coordination Ability in Taiwanese Children with and without Developmental Coordination Disorder

    Science.gov (United States)

    Zhu, Yi-Ching; Wu, Sheng K.; Cairney, John

    2011-01-01

    The purpose of this study was to investigate the associations between obesity and motor coordination ability in Taiwanese children with and without developmental coordination disorder (DCD). 2029 children (1078 boys, 951 girls) aged nine to ten years were chosen randomly from 14 elementary schools across Taiwan. We used bioelectrical impedance…

  4. Silver-Coated Nylon Dressing Plus Active DC Microcurrent for Healing of Autogenous Skin Donor Sites

    Science.gov (United States)

    2013-08-01

    requiring preoper- ative ventilator support; (d) diabetes , peripheral vascular disease, cirrhosis, or renal failure; (e) patient received medications that...of a silver dressing alone has a local electrical effect is unknown. However, a novel bioelectric dressing, incorporating zinc and silver microcells

  5. Modern bioenergy from agricultural and forestry residues in Cameroon: Potential, challenges and the way forward

    DEFF Research Database (Denmark)

    Ackom, Emmanuel; Alemagi, Dieudonne; Ackom, Nana B.;

    2013-01-01

    liters of ethanol annually to displace 18–48% of the national consumption of gasoline. Alternatively, the residues could provide 0.08–0.22 billion liters of biomass to Fischer Tropsch diesel annually to offset 17–45% of diesel fuel use. For the generation of bioelectricity, the residues could supply 0...

  6. BIOSENSING TECHNICS FOR HUMAN DETECTION. 1. THE FROG SKIN TRANSDUCER: PRELIMINARY EXPERIMENT

    Science.gov (United States)

    Isolated frog skin used as a transducer whose bioelectrical potential is measured as a function of chemical species and concentration, is shown to...log units. A high degree of variability of response between frog skins, and a lack of data on ultimate sensitivities at usefully low levels for selected substances, are major problems that remain to be examined.

  7. Land-use and alternative bioenergy pathways for waste biomass.

    Science.gov (United States)

    Campbell, J E; Block, E

    2010-11-15

    Rapid escalation in biofuels consumption may lead to a trade regime that favors exports of food-based biofuels from tropical developing countries to developed countries. There is growing interest in mitigating the land-use impacts of these potential biofuels exports by converting biorefinery waste streams into cellulosic ethanol, potentially reducing the amount of land needed to meet production goals. This increased land-use efficiency for ethanol production may lower the land-use greenhouse gas emissions of ethanol but would come at the expense of converting the wastes into bioelectricity which may offset fossil fuel-based electricity and could provide a vital source of domestic electricity in developing countries. Here we compare these alternative uses of wastes with respect to environmental and energy security outcomes considering a range of electricity production efficiencies, ethanol yields, land-use scenarios, and energy offset assumptions. For a given amount of waste biomass, we found that using bioelectricity production to offset natural gas achieves 58% greater greenhouse gas reductions than using cellulosic ethanol to offset gasoline but similar emissions when cellulosic ethanol is used to offset the need for more sugar cane ethanol. If bioelectricity offsets low-carbon energy sources such as nuclear power then the liquid fuels pathway is preferred. Exports of cellulosic ethanol may have a small impact on the energy security of importing nations while bioelectricity production may have relatively large impacts on the energy security in developing countries.

  8. Adhesion and growth of electrically-active cortical neurons on polyethyleimine patterns microprinted on PEO-PPO-PEO triblockcopolymer-coated hydrophobic surfaces

    NARCIS (Netherlands)

    Ruardij, T.G.; Boogaart, van den M.A.F.; Rutten, W.L.C.

    2002-01-01

    This paper describes the adhesion and growth of dissociated cortical neurons on chemically patterned surfaces over a time period of 30 days. The presence of neurons was demonstrated by measurement of spontaneous bioelectrical activity on a micropatterned multielectrode array. Chemical patterns were

  9. Dietary protein and urinary nitrogen in relation to 6-year changes in fat mass and fat-free mass

    DEFF Research Database (Denmark)

    Ankarfeldt, Mikkel Zøllner; Gottliebsen, K; Ängquist, L

    2015-01-01

    protein intake and subsequent changes in fat mass (FM) and FFM in longitudinal, observational data.Design:A health examination, including measures of FM and FFM by bioelectrical impedance at baseline and follow-up six years later, was conducted. Diet history interviews (DHI) were performed, and 24-hour...

  10. Intake of ruminant trans-fatty acids, assessed by diet history interview, and changes in measured body size, shape and composition

    DEFF Research Database (Denmark)

    Hansen, Camilla P; Heitmann, Berit L; Sørensen, Thorkild IA

    2016-01-01

    composition (body fat percentage). DESIGN: A 6-year follow-up study. Information on dietary intake was collected through diet history interviews, and anthropometric and bioelectrical impedance measurements were obtained by trained technicians at baseline (1987-1988) and at follow-up (1993-1994). Multiple...

  11. Body composition and energy metabolism in elderly people.

    NARCIS (Netherlands)

    Visser, M.

    1995-01-01

    This thesis describes several studies related to the three components of energy balance in elderly people: body composition, energy expenditure, and energy intake.Body composition. The applicability of the body mass index, skinfold thickness method, and multi-frequency bioelectrical impedance was te

  12. Short-Term Effects of Kinesio Taping and Cross Taping Application in the Treatment of Latent Upper Trapezius Trigger Points: A Prospective, Single-Blind, Randomized, Sham-Controlled Trial

    Science.gov (United States)

    Halski, Tomasz; Ptaszkowski, Kuba; Słupska, Lucyna; Paprocka-Borowicz, Małgorzata; Dymarek, Robert; Taradaj, Jakub; Bidzińska, Gabriela; Marczyński, Daniel; Cynarska, Aleksandra; Rosińczuk, Joanna

    2015-01-01

    Kinesio taping (KT) may be a new treatment in patients with myofascial trigger points (MTrPs). A new method available for taping practitioners is cross taping (CT). The main objective was to determine how CT, KT, and medical adhesive tape (sham group) affect the subjective assessment of resting bioelectrical activity and pain of the upper trapezius muscle (UT) in patients with MTrPs. 105 volunteers were recruited to participate. The primary outcome was resting bioelectrical activity of UT muscle as assessed by surface electromyography (sEMG) in each group and pain intensity on a visual analog scale (VAS). Assessments were collected before and after intervention and after the 24-hours follow-up. No significant differences were observed in bioelectrical activity of UT between pre-, post-, and follow-up results. In three groups patients had significantly lower pain VAS score after the intervention (CT—p tapes does not influence the resting bioelectrical activity of UT muscle and may not lead to a reduction in muscle tone in the case of MTrPs. PMID:26491458

  13. Short-Term Effects of Kinesio Taping and Cross Taping Application in the Treatment of Latent Upper Trapezius Trigger Points: A Prospective, Single-Blind, Randomized, Sham-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Tomasz Halski

    2015-01-01

    Full Text Available Kinesio taping (KT may be a new treatment in patients with myofascial trigger points (MTrPs. A new method available for taping practitioners is cross taping (CT. The main objective was to determine how CT, KT, and medical adhesive tape (sham group affect the subjective assessment of resting bioelectrical activity and pain of the upper trapezius muscle (UT in patients with MTrPs. 105 volunteers were recruited to participate. The primary outcome was resting bioelectrical activity of UT muscle as assessed by surface electromyography (sEMG in each group and pain intensity on a visual analog scale (VAS. Assessments were collected before and after intervention and after the 24-hours follow-up. No significant differences were observed in bioelectrical activity of UT between pre-, post-, and follow-up results. In three groups patients had significantly lower pain VAS score after the intervention (CT—p<0.001, KT—p<0.001, and sham—p<0.01. The Kruskal-Wallis ANOVA showed no significant differences in almost all measurements between groups. The application of all three types of tapes does not influence the resting bioelectrical activity of UT muscle and may not lead to a reduction in muscle tone in the case of MTrPs.

  14. Comparison of the Short-Term Outcomes after Postisometric Muscle Relaxation or Kinesio Taping Application for Normalization of the Upper Trapezius Muscle Tone and the Pain Relief: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Kuba Ptaszkowski

    2015-01-01

    Full Text Available The main purpose of the study was to evaluate the resting bioelectrical activity of the upper trapezius muscle (the UT muscle before and after one of the two interventions: postisometric muscle relaxation (PIR and Kinesio Taping (KT. Moreover a comparison between group results was conducted. From the initial 61 volunteers, 52 were selected after exclusion criteria and were allocated randomly to 2 groups: PIR group and KT group. Outcome measures were assessed at baseline and completion of the intervention. The primary outcome measure was change in bioelectrical activity of UT muscle evaluated by surface electromyography (sEMG. Secondary outcomes included subjective assessment of pain using visual analogue scale (VAS. Significant differences were found only in KT group: the average resting bioelectrical activity decreased by 0.8 μV (p=0.0237 and the average VAS result reduced by 2.0 points (p=0.0001. Greater decrease of VAS results was recorded in KT group compared to PIR group (p=0.0010. Both PIR and KT intervention did not influence significantly the resting bioelectrical activity of UT muscle. KT application was better for pain relief in the studied sample compared with PIR intervention.

  15. Nerve Regeneration in Vitro: Comparative Effects of Direct and Induced Current and NGF. Appendix.

    Science.gov (United States)

    1985-11-26

    that the proton economy of the cell surface may play an extremely important role in regulating many aspects of membrane functionality because most...Bioelectric. Repair and Growth Soc. 4: 24. DuBois-Reymond, E. (1843). Vorlaufiger abrifs einer untersuchung uber den sogenannten froschstrom und uber die

  16. The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research

    NARCIS (Netherlands)

    Simanov, Daniil; Mellaart-Straver, Imre; Sormacheva, Irina; Berezikov, Eugene

    2012-01-01

    Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH,

  17. [Endurance and Fatigue Caused by Local Muscular Performance in Skilled Athletes].

    Science.gov (United States)

    Popova, T V; Koryukalov, Y I; Kourova, O G

    2015-01-01

    It was the objective of this research to study the functional parameters of endurance and performance and the brain electrobiological activity during local antebrachial muscle work performance among skilled athletes and unfit people aged 18-23. We examined performance and the brain bioelectrical activity changes at local muscle work by means of an ergograph until fatigue. Our results suggested that local performance increased the spectral power of slow alpha- and theta waves as the fatigue set in, but these changes developed slower and were manifested later in the athletes than in the unfit people. Besides, tired athletes' EEGs showed alpha waves synchronization and only demonstrated a decrease in low- and high frequency beta waves indexes. Athletes show higher performance and lower fatigability if compared to unfit people during local performance, also proved by the EEG bioelectrical changes.

  18. Energy, water and climate nexus: A case study of Cameroon

    DEFF Research Database (Denmark)

    Ackom, Emmanuel

    2014-01-01

    Cameroon is a country that is well endowed with natural resources including fertile arable lands, freshwater bodies, crude oil and other energy sources. The country's oil exploitation however results in significant pollution of Cameroon's land, water and air. Modern bioenergy is seen as having good...... potential to offset the reliance on crude oil. This study investigated the biomass resource availability from agricultural residues for liquid biofuel (as transportation fuel) and bioelectricity. Our findings indicate that sustainably extracted agricultural re sidues could yield 1.11 million bone dry tons......-38% of Cameroon's current electricity consumption. The potential water savings and avoided greenhouse gas missions from the use of agricultural residues for liquid biofuels and bioelectricity relative to crude oil have also been estimated. Modern bioenergy from agricultural residues does not pose concern to food...

  19. [A layer-by-layer analysis of the components of the thalamocortical responses of the rabbit sensorimotor cortex in ontogeny].

    Science.gov (United States)

    Shimko, I A

    1991-01-01

    The data obtained in the paper showed that complex dynamics of changes of spatial-temporary situation of heterocomponent thalamocortical responses (TCR) at passing the sensorimotor cortex (SMC) was conditioned by the properties of electrogenesis of each TCR component, age and frequency of stimulation of ventroposterolateral (VPL) thalamus nucleus transformation of electric profile of the second positive component (PC-2) of the TCR at passing SMC might testify to algebraic summation in this component of bioelectric processes of several generation sources (invertible and non-invertible PC-2). The revealed properties of ontogenetic dynamics of the bioelectric fields profiles of the third negative component (NC-3) of the TCR might be the consequence of the age stages of the development and change of embryonal mechanisms of electrogenesis of the definitive ones in extremely similar negativities.

  20. Mechanism of anterior-posterior polarity control in planarians

    Energy Technology Data Exchange (ETDEWEB)

    Lange, C.S.; Steele, V.E.

    1978-01-01

    The substance which inhibits brain formation in the regenerating planarian Dugesia etrusca was found to be a large molecule, at least in part protein, which electrophoreses as an electronegative moiety in pH 6.8 buffer. A model is presented, based on this finding and previous studies, which proposes an electrochemical mechanism for the control of polarity and possibly for the maintenance of tissue organization in planarians. It is proposed that a bioelectric field exists and moves the electronegative brain-inhibiting substance in a posterior direction, establishing polarity. This model explains the polarity reversal experiments using external fields and many of the previously unexplained classical planarian experiments. Data are presented demonstrating the existence, magnitude, and polarity of this bioelectric field, which is not greatly altered upon decapitation, all in accord with predictions of the model.

  1. Primary report of noninvasive impedance monitoring of cerebral hematoma and edema in patients with intracerebral hemorrhage

    Institute of Scientific and Technical Information of China (English)

    Xia Yi Lu; Dong Wei-Wei; Yang Hao; Long Men; Yang Hua

    2000-01-01

    Background and Objective Brain edema is one of the most important clinical process in many diseases. Tissue impedance monitoring offers a non-invasive, bedside, rapid, and reliable technique for the monitoring of the brain edema. Methods We use a bioelectrical impedance(BEI) monitoring unit to record the brain impedance in the healthy volunteer and the patients with intracerebral hemorrhage. Percent of BEI variations were calculation. Results and Conclusions Brain BEI haven f any difference between both hemispheres in normal ones. In 48hrs, BEI value at hematoma-side was obviously decreased; after 48hrs, BEI value was obviously increased and continue to tenth day. Brain bioelectrical impedance monitoring, particularly noninvasively, is a first time in this field. The primary results show brain BEI could reflect the evolution of cerebral hematoma and edema.

  2. Neotropical electric fishes (Gymnotiformes as model organisms for bioassays

    Directory of Open Access Journals (Sweden)

    Milena Ferreira

    2015-04-01

    Full Text Available Electric fishes (Gymnotiformes inhabit Central and South America and form a relatively large group with more than 200 species. Besides a taxonomic challenge due to their still unresolved systematic, wide distribution and the variety of habitats they occupy, these fishes have been intensively studied due to their peculiar use of bioelectricity for electrolocation and communication. Conventional analysis of cells, tissues and organs have been complemented with the studies on the electric organ discharges of these fishes. This review compiles the results of 13 bioassays developed during the last 50 years, which used the quickness, low costs and functionality of the bioelectric data collection of Gymnotiformes to evaluate the effects of environmental contaminants and neuroactive drugs.

  3. Imaging electric field dynamics with graphene optoelectronics

    Science.gov (United States)

    Horng, Jason; Balch, Halleh B.; McGuire, Allister F.; Tsai, Hsin-Zon; Forrester, Patrick R.; Crommie, Michael F.; Cui, Bianxiao; Wang, Feng

    2016-12-01

    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.

  4. Exploring redox-mediating characteristics of textile dye-bearing microbial fuel cells: thionin and malachite green.

    Science.gov (United States)

    Chen, Bor-Yann; Xu, Bin; Qin, Lian-Jie; Lan, John Chi-Wei; Hsueh, Chung-Chuan

    2014-10-01

    Prior studies indicated that biodecolorized intermediates of azo dyes could act as electron shuttles to stimulate wastewater decolorization and bioelectricity generation (WD&BG) in microbial fuel cells (MFCs). This study tended to explore whether non-azo textile dyes (i.e., thionin and malachite green) could also own such redox-mediating capabilities for WD&BG. Prior findings mentioned that OH and/or NH2 substitute-containing auxochrome compounds (e.g., 2-aminophenol and 1,2-dihydroxybenzene) could effectively mediate electron transport in MFCs for simultaneous WD&BG. This work clearly suggested that the presence of electron-mediating textile dyes (e.g., thionin and malachite green (MG)) in MFCs is promising to stimulate color removal and bioelectricity generation. That is, using MFCs as operation strategy for wastewater biodecolorization is economically promising in industrial applications due to autocatalytic acceleration of electron-flux for WD&BG in MFCs.

  5. Neotropical electric fishes (Gymnotiformes) as model organisms for bioassays

    Institute of Scientific and Technical Information of China (English)

    Milena Ferreira; Isac Silva de Jesus; Eliana Feldberg; JoséAntônioAlves-Gomes

    2015-01-01

    Electric fishes (Gymnotiformes) inhabit Central and South America and form a relatively large group with more than 200 species. Besides a taxonomic challenge due to their still unresolved systematic, wide distribution and the variety of habitats they occupy, these fishes have been intensively studied due to their peculiar use of bioelectricity for electrolocation and communication. Conventional analysis of cells, tissues and organs have been complemented with the studies on the electric organ discharges of these fishes. This review compiles the results of 13 bioassays developed during the last 50 years, which used the quickness, low costs and functionality of the bioelectric data collection of Gymnotiformes to evaluate the effects of environmental contaminants and neuroactive drugs.

  6. Microbial fuel cell as new technol

    Directory of Open Access Journals (Sweden)

    Mostafa Rahimnejad

    2015-09-01

    Full Text Available Recently, great attentions have been paid to microbial fuel cells (MFCs due to their mild operating conditions and using variety of biodegradable substrates as fuel. The traditional MFC consisted of anode and cathode compartments but there are single chamber MFCs. Microorganisms actively catabolize substrate, and bioelectricities are generated. MFCs could be utilized as power generator in small devices such as biosensor. Besides the advantages of this technology, it still faces practical barriers such as low power and current density. In the present article different parts of MFC such as anode, cathode and membrane have been reviewed and to overcome the practical challenges in this field some practical options have been suggested. Also, this research review demonstrates the improvement of MFCs with summarization of their advantageous and possible applications in future application. Also, Different key factors affecting bioelectricity generation on MFCs were investigated and these key parameters are fully discussed.

  7. [Diagnostic significance of the spinal-brain stem polysynaptic reflex and the period of inhibition].

    Science.gov (United States)

    Ivanichev, G A

    1985-01-01

    Electrical stimulation of the radial nerve associated with voluntary contraction of the shoulder girdle inhibited bioelectrical activity not only in the muscles of the hypothenar but also in the proximal muscles. In resting muscles, such stimulation elicited a reflex response with a large latent period. With weak voluntary tension stimulation elicited a reflex response while in the presence of considerable contraction the reflex response merged with bioelectrical activity, with a clearly demonstrable subsequent period of inhibition. The current viewpoint about the antidromal blockade of the segmental motoneurons is debated. It is suggested that the polysynaptic reflex and the inhibition period are connected with the same level of realization -- the oral portions of the brain stem.

  8. Merging metabolism and power: development of a novel photobioelectric device driven by photosynthesis and respiration.

    Directory of Open Access Journals (Sweden)

    Ryan J Powell

    Full Text Available Generation of renewable energy is one of the grand challenges facing our society. We present a new bio-electric technology driven by chemical gradients generated by photosynthesis and respiration. The system does not require pure cultures nor particular species as it works with the core metabolic principles that define phototrophs and heterotrophs. The biology is interfaced with electrochemistry with an alkaline aluminum oxide cell design. In field trials we show the system is robust and can work with an undefined natural microbial community. Power generated is light and photosynthesis dependent. It achieved a peak power output of 33 watts/m(2 electrode. The design is simple, low cost and works with the biological processes driving the system by removing waste products that can impede growth. This system is a new class of bio-electric device and may have practical implications for algal biofuel production and powering remote sensing devices.

  9. Bioenergy in Brazil and Europe: a comparative analysis; Bioenergia no Brasil e na Europa: uma analise comparativa

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Nivalde Jose de [Universidade Federal do Rio de Janeiro (IE/UFRJ), RJ (Brazil). Inst. de Economia], e-mail: nivalde@ie.ufrj.br; Dantas, Guilherme de Azevedo [Universidade Federal do Rio de Janeiro (GESEL/UFRJ), RJ (Brazil). Grupo de Estudos do Setor Eletrico], e-mail: guilhermecrvg@yahoo.com.br

    2008-07-01

    A higher application of bioenergy is one of the existing ways to adequate the necessity of an expansion in the energy supply with the mitigation of global warming. The consumption of biofuel in the transport sector is the most usual and important use of biomass, however, bioenergy may also have a relevant contribution to the world electrical matrix. A comparative analysis shows that Brazil has consolidate the usage of biofuel while Europe is having problems to accomplish the biofuels levels established in the European Union guidelines. However, some european countries are developing their bioelectrical generation potential in a much more efficient way than Brazil. Therefore , brazilian policies to support bioelectricity should observe the successful instruments applied in Europe. (author)

  10. Cells and Yin-Yang polarity- (Towards greater similarity between the animate and the inanimate

    Directory of Open Access Journals (Sweden)

    Kothari M

    1978-01-01

    Full Text Available A cell-plant or animal-is proving a bioelectric wonder al-ready boasting of pyro-, piezo-, ferroelectricity, solid state and electretism as eminent exhibits and probable functional mechan-isms. A cell, its parts, and its products owe the bioelectric boon to inherent and universal polarity pregnant with dipolar electro-magnetic moment. The cytologic bipolarity prompts a hypothesis that the cell and its world may be no exception to the working of Yin-Yang, the Taoistic concept o f all-pervading reality. Nuclear, cytoplasmic, gametic and zygotic considerations compellingly suggest that Yin-Yang does prevail, making us and′ our cells basically field-effects, thus erasing further the distinction between male and female, animate and inanimate, biomass and bioenergy.

  11. Biophysical aspects of the influence of electromagnetic fields (EMF) on the human body Influencia de los campos electromagnéticos en el organismo humano: aspectos biofísicos

    OpenAIRE

    Napaleon Hernández

    1993-01-01

     

    Some historical aspects of biomagnetism and of the various steps that led to the development of bioelectricity and electro technique are summarized. Alterations observed in individuals working for long periods of time in contact with artificial EMF are described as well as the correlation between natural EMF and accidentality. The utilization of EMF for therapeutic purposes ...

  12. Extracellular electron transfer mechanism in Shewanella loihica PV- 4 biofilms formed at indium tin oxide and graphite electrodes

    OpenAIRE

    2013-01-01

    Electroactive biofilms are capable of extracellular electron transfer to insoluble metal oxides and electrodes; such biofilms are relevant to biogeochemistry, bioremediation, and bioelectricity production. We investigated the extracellular electron transfer mechanisms in Shewanella loihica PV-4 viable biofilms grown at indium tin oxide (ITO) and graphite electrodes in potentiostat-controlled electrochemical cells poised at 0.2 V vs. Ag/AgCl. Chronoamperometry and confocal microscopy showed hi...

  13. Interface entre neurones et puces structurées électroniques pour la détection de potentiels d'action

    OpenAIRE

    Larramendy, Florian

    2013-01-01

    The interface man / machine had followed of many researches in biotechnology. A part of these researches concern the interconnections brain / machine. Indeed, the brain arranges numerous intellectual connections thanks to neurons. These neurons communicate between them and propagate information thanks to a "bio-electric" signal called action potential. The objective of my doctoral thesis is to measure this signal thanks to ion sensitive field effect transistor (ISFET). The ISFET process was m...

  14. Corrosion Protection of Al/Au/ZnO Anode for Hybrid Cell Application

    OpenAIRE

    2015-01-01

    Effective protection of power sources from corrosion is critical in the development of abiotic fuel cells, biofuel cells, hybrid cells and biobateries for implantable bioelectronics. Corrosion of these bioelectronic devices result in device inability to generate bioelectricity. In this paper Al/Au/ZnO was considered as a possible anodic substrate for the development of a hybrid cell. The protective abilities of corrosive resistant aluminum hydroxide and zinc phosphite composite films formed o...

  15. Differential Effect of Isooctane Doses on HaCaT and HeLa: A Multimodal Analysis

    OpenAIRE

    Lopamudra Das; Sanmitra Basu; Sanghamitra Sengupta; Soumen Das; Jyotirmoy Chatterjee

    2014-01-01

    A multimodal approach is effective in analyzing biological problems critically and thus also useful in assessing cytotoxicity under chemicals assaults. In this study effects of isooctane, an organic solvent and component of gasoline produced in petroleum industries, have been explored on normal (HaCaT) and cancerous (HeLa) epithelial cells. Besides morphological alterations, impacts on viability, prime molecular expressions, and bioelectrical properties on exposure to different doses of isooc...

  16. THE ALTERATION OF VISUAL PERCEPTUAL MECHANISMS BY CHEMICAL AGENTS.

    Science.gov (United States)

    positive reinforcement . The visual conditioned stimulus (CS) was presented at 10 cps in three paradigms: (1) selection of the single lighted panel (light-dark discrimination); (2) discrimination between similar patterns presented at differing intensities (total luminous flux discrimination); and (3) discrimination between two differing geometric patterns of similar intensity. The CS figures were pulsed to allow frequency labeling of brain bioelectric activity. This activity was collected during habituation to the conditioning stimulus, during training and during stabilized

  17. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardia

  18. Fast-Food Restaurant Advertising on Television and Its Influence on Youth Body Composition

    OpenAIRE

    Grossman, Michael; Tekin, Erdal; Wada, Roy

    2012-01-01

    We examine the effects of fast-food restaurant advertising on television on the body composition of adolescents as measured by percentage body fat (PBF) and to assess the sensitivity of these effects to using conventional measures of youth obesity based on body-mass index (BMI). We merge measures of body composition from bioelectrical-impedance analysis (BIA) and dual-energy x-ray absorptiometry (DXA) from the National Health and Nutrition Examination Survey with individual level data from th...

  19. H,K-ATPase Protein Localization and Kir4.1 Function Reveal Concordance of 3 Axes During Early Determination of Left-Right Asymmetry

    OpenAIRE

    Aw, Sherry; Adams, Dany S.; Qiu, Dayong; Levin, Michael

    2007-01-01

    Consistent laterality is a fascinating problem, and study of the Xenopus embryo has led to molecular characterization of extremely early steps in left-right patterning: bioelectrical signals produced by ion pumps functioning upstream of asymmetric gene expression. Here, we reveal a number of novel aspects of the H+/K+-ATPase module in chick and frog embryos. Maternal H+/K+-ATPase subunits are asymmetrically localized along the left-right, dorso-ventral, and animal-vegetal axes during the firs...

  20. Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study

    OpenAIRE

    Riess Hanno; Doerken Bernd; Stieler Jens; Gövercin Mehmet; Arnold Dirk; Pelzer Uwe; Oettle Helmut

    2010-01-01

    Abstract Background Cachexia is a common problem in patients (pts) suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to their illness. Various methods of supplementary nutrition (enteral, parenteral) are practised. In patients with advanced pancreatic cancer (APC), phase angle, determined by bio-electrical impedance analysis (BIA), seems to be a survival predictor. The positive influence o...

  1. An Implementation of Remote Monitoring Standing Tree Diameter at Breast Height

    OpenAIRE

    Liyuan Jiang; Wenbin Li; Jiangming Kan; Zhibin Hao; Qing Xu

    2013-01-01

    Studies show that there is electric potential difference between the internal part of tree and the soil, but the mechanism is not clear, possibly associated with tree species, environmental factors and DBH (diameter at breast height) of tree. In order to research the mechanism and change rules, it is necessary to measure bioelectricity, environmental factors and DBH of tree, among which the DBH and its growth is an important indicator. A kind of DBH of tree and its growth automatic measuring ...

  2. Observational study of maternal anthropometry and fetal insulin

    OpenAIRE

    Soltani-K, H; Bruce, C; Fraser, R

    1999-01-01

    AIMS—To examine the relation between maternal body fat and fetal metabolism.
METHODS—In this observational study, cord blood samples were collected from 60 infants of healthy women for the measurement of insulin and C peptide concentrations. Maternal weight, height, body mass index (BMI) and body composition (skinfold thickness measurements and bioelectrical impedance) were assessed at 13-15 weeks of gestation. Twenty five of the volunteers agreed to have a 75 g oral gluc...

  3. Energy expenditure in caving.

    Science.gov (United States)

    Antoni, Giorgia; Marini, Elisabetta; Curreli, Nicoletta; Tuveri, Valerio; Comandini, Ornella; Cabras, Stefano; Gabba, Silvia; Madeddu, Clelia; Crisafulli, Antonio; Rinaldi, Andrea C

    2017-01-01

    The aim of this study was to determine the energy expenditure of a group of cavers of both genders and different ages and experience during a 10 hour subterranean exploration, using portable metabolimeters. The impact of caving activity on body composition and hydration were also assessed through bioelectrical impedance, and nutritional habits of cavers surveyed. During cave activity, measured total energy expenditure (TEE) was in the range 225-287 kcal/h for women-men (MET = 4.1), respectively; subjects had an energy intake from food in the range 1000-1200 kcal, thus inadequate to restore lost calories. Bayesian statistical analysis estimated the effect of predictive variables on TEE, revealing that experienced subjects had a 5% lower TEE than the less skilled ones and that women required a comparatively larger energy expenditure than men to perform the same task. BIVA (bioelectrical impedance vector analysis) showed that subjects were within the range of normal hydration before and after cave activity, but bioelectrical changes indicated a reduction of extracellular water in men, which might result in hypo-osmolal dehydration in the case of prolonged underground exercise. All these facts should be considered when planning cave explorations, preparing training programs for subjects practising caving, and optimizing a diet for cavers. Further, information gathered through this study could be of value to reduce accidents in caves related to increase in fatigue.

  4. Effect of artificial electric fields on plants grown under microgravity conditions.

    Science.gov (United States)

    Nechitailo, G; Gordeev, A

    2001-01-01

    Ionic and structural hetorogeneity of cells, tissues, and organs of plants are associated with a spectrum of electric characteristics such as bioelectric potentials, electrical conductance, and bioelectric permeability. An important determinant for the plant function is electric properties of the cell membranes and organelles which maintain energy and substance exchange with the environment. Enzymes and other biologically active substances have a powerful charge at the molecular level. Finally, all molecules, including those of water, represent dipoles, and this determines their reactive capacity. A major determinant is the bioelectric polarity of a plant is genetically predetermined and cannot be modified. It is an intrinsic structural feature of the organism whose evolution advent was mediated by gravity. An illustrative presentation of polarity is the downward growth of the roots and upward growth of stems in the Earth's gravitation field. However, gravity is a critical, but not the sole determinant of the plant organism polarization. Potent polarizing effects are exerted by light, the electromagnetic field, moisture, and other factors. It is known that plant cultivation in an upturned position is associated with impairment of water and nutrient uptake, resulting in dyscoordination of physiological processes, growth and developmental retardation. These abnormalities were characteristic when early attempts were made to grow plants in weightlessness conditions.

  5. An optical microfluidic platform for spatiotemporal biofilm treatment monitoring

    Science.gov (United States)

    Kim, Young Wook; Mosteller, Matthew P.; Subramanian, Sowmya; Meyer, Mariana T.; Bentley, William E.; Ghodssi, Reza

    2016-01-01

    Bacterial biofilms constitute in excess of 65% of clinical microbial infections, with the antibiotic treatment of biofilm infections posing a unique challenge due to their high antibiotic tolerance. Recent studies performed in our group have demonstrated that a bioelectric effect featuring low-intensity electric signals combined with antibiotics can significantly improve the efficacy of biofilm treatment. In this work, we demonstrate the bioelectric effect using sub-micron thick planar electrodes in a microfluidic device. This is critical in efforts to develop microsystems for clinical biofilm infection management, including both in vivo and in vitro applications. Adaptation of the method to the microscale, for example, can enable the development of localized biofilm infection treatment using microfabricated medical devices, while augmenting existing capabilities to perform biofilm management beyond the clinical realm. Furthermore, due to scale-down of the system, the voltage requirement for inducing the electric field is reduced further below the media electrolysis threshold. Enhanced biofilm treatment using the bioelectric effect in the developed microfluidic device elicited a 56% greater reduction in viable cell density and 26% further decrease in biomass growth compared to traditional antibiotic therapy. This biofilm treatment efficacy, demonstrated in a micro-scale device and utilizing biocompatible voltage ranges, encourages the use of this method for future clinical biofilm treatment applications.

  6. Effect of artificial electric fields on plants grown under microgravity conditions

    Science.gov (United States)

    Nechitailo, G.; Gordeev, A.

    2001-01-01

    Ionic and structural hetorogeneity of cells, tissues, and organs of plants are associated with a spectrum of electric characteristics such as bioelectric potentials, electrical conductance, and bioelectric permeability. An important determinant for the plant function is electric properties of the cell membranes and organelles which maintain energy and substance exchange with the environment. Enzymes and other biologically active substances have a powerful charge at the molecular level. Finally, all molecules, including those of water, represent dipoles, and this determines their reactive capacity. A major determinant is the bioelectric polarity of a plant is genetically predetermined and cannot be modified. It is an intrinsic structural feature of the organism whose evolution advent was mediated by gravity. An illustrative presentation of polarity is the downward growth of the roots and upward growth of stems in the Earth's gravitation field. However, gravity is a critical, but not the sole determinant of the plant organism polarization. Potent polarizing effects are exerted by light, the electromagnetic field, moisture, and other factors. It is known that plant cultivation in an upturned position is associated with impairment of water and nutrient uptake, resulting in dyscoordination of physiological processes, growth and developmental retardation. These abnormalities were characteristic when early attempts were made to grow plants in weightlessness conditions.

  7. CONSTRUCTION OF DOUBLE CHAMBERED MICROBIAL FUEL CELL (MFC USING HOUSEHOLD MATERIALS AND BACILLUS MEGATERIUM ISOLATE FROM TEA GARDEN SOIL

    Directory of Open Access Journals (Sweden)

    Debajit Borah

    2013-08-01

    Full Text Available The current study was carried out for the isolation and screening of potential bioelectricity generating bacteria from tea garden soil samples and also to construct an indigenous microbial fuel cell (MFC using house hold materials. Bacillus megaterium was found to the best isolate for the production of bioelectricity, out of a total of 25 bacterial isolates from soil samples of Lepetkata Tea Estate of Dibrugarh district of Assam. The isolate was identified on the basis of staining techniques and biochemical characteristics. Double chambered MFC was constructed by using two poly acrylic containers of 500 ml volume each. The two chambers were connected using an agar salt bridge and carbon rods were used as electrodes. The electricity generated by the isolate was compared using glucose and fructose as sole carbon source in minimal media. The maximum voltage was found to be 440 mV in presence of glucose as sole carbon source after 84 hrs of incubation at room temperature. The voltage was further increased up to 698 mV after the media was supplemented with 1.5 % (w/v yeast extract, which would have served as additional source of vitamin to the bacteria to proliferate. During the entire study, the experimental set up was allowed to incubate at room temperature and occasional shaking was done manually, hence no external electricity was required. With all the above features the isolate Bacillus megaterium was found to be a good source of bioelectricity.

  8. Anditalea andensis ANESC-ST--An Alkaliphilic Halotolerant Bacterium Capable of Electricity Generation under Alkaline-Saline Conditions.

    Directory of Open Access Journals (Sweden)

    Wei Shi

    Full Text Available A great challenge in wastewater bioremediation is the sustained activity of viable microorganisms, which can contribute to the breakdown of waste contaminants, especially in alkaline pH conditions. Identification of extremophiles with bioremediation capability can improve the efficiency of wastewater treatment. Here, we report the discovery of an electrochemically active alkaliphilic halotolerant bacterium, Anditalea andensis ANESC-ST (=CICC10485T=NCCB 100412T, which is capable of generating bioelectricity in alkaline-saline conditions. A. andensis ANESC-ST was shown to grow in alkaline conditions between pH 7.0-11.0 and also under high salt condition (up to 4 wt% NaCl. Electrical output was further demonstrated in microbial fuel cells (MFCs with an average current density of ~0.5 µA/cm2, even under the harsh condition of 4 wt% NaCl and pH 9.0. Subsequent introduction of secreted extracellular metabolites into MFCs inoculated with Escherichia coli or Pseudomonas aeruginosa yielded enhanced electrical output. The ability of A. andensis ANESC-ST to generate energy under alkaline-saline conditions points towards a solution for bioelectricity recovery from alkaline-saline wastewater. This is the first report of A.andensis ANESC-ST producing bioelectricity at high salt concentration and pH.

  9. Nutritional assessment in patients with cirrhosis

    Directory of Open Access Journals (Sweden)

    Sabrina Alves Fernandes

    2012-03-01

    Full Text Available CONTEXT: Malnutrition in cirrhotic patients with end-stage disease is common, and the degree of nutritional debilitation can play an important role in the pathogenesis of complications and cause a negative impact on prognosis. However, it involves difficulties and controversies regarding the identification of the best nutritional assessment method. OBJECTIVE: To identify a method that provides a safe and effective nutritional diagnosis. METHODS: Cross-sectional study with 129 cirrhotic patients. Anthropometric measurements, subjective global assessment, hand grip strength and bioelectrical impedance. RESULTS: Through phase angle of bioelectrical impedance analysis (BIA method, significant associations with Child-Pugh (P = 0.008, age group and gender were observed. The ROC (receiver operator characteristic curve was generated to determine the best cutoff point of the phase angle of cirrhotic patients, serving as one of the reference parameters for the nutritional assessment with bioimpedance in this study, considering the classification through Child-Pugh score as the reference standard for the clinical conditions of patients with cirrhosis. CONCLUSIONS: The assessment through bioelectrical impedance presented a statistically significant correlation with Child-Pugh score. The identification of phase angle of 5.44º is the new parameter suggested for the classification of the nutritional conditions of cirrhotic patients.

  10. Mechanism of low-level microwave radiation effect on nervous system.

    Science.gov (United States)

    Hinrikus, Hiie; Bachmann, Maie; Karai, Denis; Lass, Jaanus

    2017-01-01

    The aim of this study is to explain the mechanism of the effect of low-level modulated microwave radiation on brain bioelectrical oscillations. The proposed model of excitation by low-level microwave radiation bases on the influence of water polarization on hydrogen bonding forces between water molecules, caused by this the enhancement of diffusion and consequences on neurotransmitters transit time and neuron resting potential. Modulated microwave radiation causes periodic alteration of the neurophysiologic parameters and parametric excitation of brain bioelectric oscillations. The experiments to detect logical outcome of the mechanism on physiological level were carried out on 15 human volunteers. The 450-MHz microwave radiation modulated at 7, 40 and 1000 Hz frequencies was applied at the field power density of 0.16 mW/cm(2). A relative change in the EEG power with and without radiation during 10 cycles was used as a quantitative measure. Experimental data demonstrated that modulated at 40 Hz microwave radiation enhanced EEG power in EEG alpha and beta frequency bands. No significant alterations were detected at 7 and 1000 Hz modulation frequencies. These results are in good agreement with the theory of parametric excitation of the brain bioelectric oscillations caused by the periodic alteration of neurophysiologic parameters and support the proposed mechanism. The proposed theoretical framework has been shown to predict the results of experimental study. The suggested mechanism, free of the restrictions related to field strength or time constant, is the first one providing explanation of low-level microwave radiation effects.

  11. DC feedback for wide band frequency fixed current source

    Directory of Open Access Journals (Sweden)

    Aoday Hashim Mohamad Al-Rawi

    2013-03-01

    Full Text Available Alternating current sources are mainly used in bioelectrical impedance devices. Nowadays 50 – 100 kHz bioelectrical impedance devices are commonly used for body composition analysis. High frequency bioelectrical impedance analysis devices are mostly used in bioimpedance tomography and blood analysis. High speed op-amps and voltage comparators are used in this circuit. Direct current feedback is used to prevent delay. An N-Channel J-FET transistor was used to establish the voltage controlled gain amplifier (VCG. A sine wave signal has been applied as input voltage. The value of this signal should be constant in 170 mV rms to keep the output current in about 1 mA rms. Four frequencies; 100 kHz, 1 MHz, 2 MHz and 3.2 MHz were applied to the circuit and the current was measured for different load resistances. The results showed that the current was stable for changes in the resistor load, bouncing around an average point as a result of bouncing DC feedback.

  12. Optogenetics in Developmental Biology: using light to control ion flux-dependent signals in Xenopus embryos.

    Science.gov (United States)

    Spencer Adams, Dany; Lemire, Joan M; Kramer, Richard H; Levin, Michael

    2014-01-01

    Developmental bioelectricity, electrical signaling among non-excitable cells, is now known to regulate proliferation, apoptosis, gene expression, and patterning during development. The extraordinary temporal and spatial resolution offered by optogenetics could revolutionize the study of bioelectricity the same way it has revolutionized neuroscience. There is, however, no guide to adapting optogenetics to patterning systems. To fill this gap, we used optogenetic reagents, both proteins and photochemical switches, to vary steady-state bioelectrical properties of non-spiking embryonic cells in Xenopus laevis. We injected mRNA for various proteins, including Channelrhodopsins and Archaerhodopsin, into 1-8 cell embryos, or soaked embryos in media containing photochemical switches, then examined the effect of light and dark on membrane voltage (Vmem) using both electrodes and fluorescent membrane voltage reporters. We also scored tadpoles for known effects of varying Vmem, including left-right asymmetry disruption, hyperpigmentation, and craniofacial phenotypes. The majority of reagents we tested caused a significant increase in the percentage of light-exposed tadpoles showing relevant phenotypes; however, the majority of reagents also induced phenotypes in controls kept in the dark. Experiments on this "dark phenotype" yielded evidence that the direction of ion flux via common optogenetic reagents may be reversed, or unpredictable in non-neural cells. When used in combination with rigorous controls, optogenetics can be a powerful tool for investigating ion-flux based signaling in non-excitable systems. Nonetheless, it is crucial that new reagents be designed with these non-neural cell types in mind.

  13. Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms.

    Science.gov (United States)

    Emmons-Bell, Maya; Durant, Fallon; Hammelman, Jennifer; Bessonov, Nicholas; Volpert, Vitaly; Morokuma, Junji; Pinet, Kaylinnette; Adams, Dany S; Pietak, Alexis; Lobo, Daniel; Levin, Michael

    2015-11-24

    The shape of an animal body plan is constructed from protein components encoded by the genome. However, bioelectric networks composed of many cell types have their own intrinsic dynamics, and can drive distinct morphological outcomes during embryogenesis and regeneration. Planarian flatworms are a popular system for exploring body plan patterning due to their regenerative capacity, but despite considerable molecular information regarding stem cell differentiation and basic axial patterning, very little is known about how distinct head shapes are produced. Here, we show that after decapitation in G. dorotocephala, a transient perturbation of physiological connectivity among cells (using the gap junction blocker octanol) can result in regenerated heads with quite different shapes, stochastically matching other known species of planaria (S. mediterranea, D. japonica, and P. felina). We use morphometric analysis to quantify the ability of physiological network perturbations to induce different species-specific head shapes from the same genome. Moreover, we present a computational agent-based model of cell and physical dynamics during regeneration that quantitatively reproduces the observed shape changes. Morphological alterations induced in a genomically wild-type G. dorotocephala during regeneration include not only the shape of the head but also the morphology of the brain, the characteristic distribution of adult stem cells (neoblasts), and the bioelectric gradients of resting potential within the anterior tissues. Interestingly, the shape change is not permanent; after regeneration is complete, intact animals remodel back to G. dorotocephala-appropriate head shape within several weeks in a secondary phase of remodeling following initial complete regeneration. We present a conceptual model to guide future work to delineate the molecular mechanisms by which bioelectric networks stochastically select among a small set of discrete head morphologies. Taken together

  14. Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms

    Directory of Open Access Journals (Sweden)

    Maya Emmons-Bell

    2015-11-01

    Full Text Available The shape of an animal body plan is constructed from protein components encoded by the genome. However, bioelectric networks composed of many cell types have their own intrinsic dynamics, and can drive distinct morphological outcomes during embryogenesis and regeneration. Planarian flatworms are a popular system for exploring body plan patterning due to their regenerative capacity, but despite considerable molecular information regarding stem cell differentiation and basic axial patterning, very little is known about how distinct head shapes are produced. Here, we show that after decapitation in G. dorotocephala, a transient perturbation of physiological connectivity among cells (using the gap junction blocker octanol can result in regenerated heads with quite different shapes, stochastically matching other known species of planaria (S. mediterranea, D. japonica, and P. felina. We use morphometric analysis to quantify the ability of physiological network perturbations to induce different species-specific head shapes from the same genome. Moreover, we present a computational agent-based model of cell and physical dynamics during regeneration that quantitatively reproduces the observed shape changes. Morphological alterations induced in a genomically wild-type G. dorotocephala during regeneration include not only the shape of the head but also the morphology of the brain, the characteristic distribution of adult stem cells (neoblasts, and the bioelectric gradients of resting potential within the anterior tissues. Interestingly, the shape change is not permanent; after regeneration is complete, intact animals remodel back to G. dorotocephala-appropriate head shape within several weeks in a secondary phase of remodeling following initial complete regeneration. We present a conceptual model to guide future work to delineate the molecular mechanisms by which bioelectric networks stochastically select among a small set of discrete head morphologies

  15. Changes in body composition during weight loss in obese subjects in the NUGENOB study

    DEFF Research Database (Denmark)

    Verdich, C.; Barbe, P.; Petersen, Martin

    2011-01-01

    AIM: We studied the accuracy of bioelectrical impedance analysis (BIA) to assess changes in body composition during moderate weight loss in obese subjects. METHODS: Estimates of changes in fat mass (FM) and fat-free mass (FFM) by BIA were compared with those by dual-energy X-ray absorptiometry (DXA......) as the reference method during a 10-week standardized weight-loss intervention. In obese women (age: 20-50years, mean BMI: 33.8kg/m(2)) participating in a European multicentre trial (nutrient-gene interactions in human obesity [NUGENOB]), body composition was assessed by BIA (Bodystat QuadScan 4000) and DXA (Lunar...

  16. [Cardioprotective effect of drugs with antioxidant activity in acute cerebral ischemia].

    Science.gov (United States)

    Stoliarova, V V

    2001-01-01

    The bioelectric cardiac activity was studied in the experiments on white mice with an acute cerebral blood circulation disorder. It was found that he resulting EEG changes possess a specific character, with the sympathoadrenal system stimulation playing an important role in the acute cerebrocardiac syndrome development. The antioxidant-type agents such as emoxypine (50 mg/kg), mexidol (50 mg/kg), and cytochrome C (10 mg/kg) produce a significant cardioprotective effect in the test animals with experimental cerebral ischemia, which was comparable with the effect of propranolol (obsidane) (0.1 mg/kg).

  17. Cross MFF—analysis in studying the obsessive-compulsive disorder

    Science.gov (United States)

    Demin, S. A.; Panischev, O. Yu; Demina, N. Yu

    2016-08-01

    There were demonstrated capabilities of the Memory Function Formalism (MFF) in analyzing cross correlations in human brain bioelectric activity at obsessive-compulsive disorder (OCD). To extract the information about collective phenomena in (electroencephalogram) EEG brain activity we use the power spectra of memory functions and the memory quantifiers. We discover the pairs of the electrodes with the greatest differences in dynamic and stochastic parameters for patients with the different condition. The high OCD condition is characterized by the influence of the memory effects. The MFF cross correlation analysis allow to describe the collective phenomena in EEG dynamics at OCD including the dynamic, spectral and stochastic behavior.

  18. [Benzodiazepines and limbic system. Anxiety and vigilance (author's transl)].

    Science.gov (United States)

    Gekiere, F; Allegre, G; Brindeau, F; Borenstein, P

    1980-01-01

    A neurophysiological study of 4 benzodiazepines in the free implanted cat serves as basis to a discussion concerning tranquilizers, anxiety and vigilance. The electrophysiological and behavioural effects of diazepam, nitrazepam, lorazepam and of clorazepate dipotassique are analysed and compared between them and other psychotropic drugs. Their mode of action on the behaviour, on the bioelectric cortical and hippocampal rhythms, is explained according to recent biochemical data. The relations with anxiety, vigilance and neuro-psycho-physiologic mechanisms which subtend them are discussed at the light of clinical effects provoked by substances called tranquillizers.

  19. A system for automated quantification of cutaneous electrogastrograms

    DEFF Research Database (Denmark)

    Paskaranandavadivel, Niranchan; Bull, Simon Henry; Parsell, Doug;

    2015-01-01

    recordings from the gastric mucosa and serosa in a reliable and efficient manner. In particular, the frequency and amplitude of the gastric slow waves were computed, after which signal integrity checks were performed to assess if the signals are valid. For validation, manual estimates of the frequency...... and amplitude were compared to automated estimates. The methods were packaged into a software executable which processes the data and presents the results in an intuitive graphical and a spreadsheet formats. Automated EGG analysis allows for clinical translation of bio-electrical analysis for potential...

  20. Principles of Biomedical Engineering

    CERN Document Server

    Madihally, Sundararajan V

    2010-01-01

    Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Supported with over 145 illustrations, the book discusses bioelectrical systems, mechanical analysis of biological tissues and organs, biomaterial selection, compartmental modeling, and biomedical instrumentation. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics.Structured as a complete text for students with some engineering background, the book also makes a valuable refere

  1. Effects of antiepileptic drugs in electrophysiological tests.

    Science.gov (United States)

    Rump, S; Kowalczyk, M

    1987-01-01

    Methods of the study of antiepileptic drugs activity by means of analysis of their effects on bioelectrical ictal phenomena in the animal brain are described. The paper deals especially with EEG signal processing methods. Application of various nonparametric models (e.g. interval-amplitude scatter plots, power spectra analysis) as well as parametric models (e.g. autoregressive model, segmentation analysis) is discussed. A discriminative approach to some of these methods (especially to autoregressive model) is also presented. Special attention is stressed on the value of these methods for the study of anticonvulsant drugs activity.

  2. MANIFOLD LEARNING FOR ANALYSIS OF LOW-ORDER NONLINEAR DYNAMICS IN HIGH-DIMENSIONAL ELECTROCARDIOGRAPHIC SIGNALS.

    Science.gov (United States)

    Erem, B; Stovicek, P; Brooks, D H

    2012-07-12

    The dynamical structure of electrical recordings from the heart or torso surface is a valuable source of information about cardiac physiological behavior. In this paper, we use an existing data-driven technique for manifold identification to reveal electrophysiologically significant changes in the underlying dynamical structure of these signals. Our results suggest that this analysis tool characterizes and differentiates important parameters of cardiac bioelectric activity through their dynamic behavior, suggesting the potential to serve as an effective dynamic constraint in the context of inverse solutions.

  3. Body water distribution and risk of cardiovascular morbidity and mortality in a healthy population: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Nikoline Nygård Knudsen

    Full Text Available BACKGROUND: Early alterations in the cardiovascular structure and function may change normal body water distribution. The resulting fluid shifts may thus serve as an early marker for cardiovascular disease. However, studies examining this in healthy populations are absent. OBJECTIVE: This study examined the association between the proportion of total body water that is extracellular water and subsequent development of non-fatal or fatal cardiovascular disease in a healthy population. METHOD: Bioelectrical impedance spectroscopy is an easy-to-use, non-invasive and relatively inexpensive technique to evaluate changes in body water distribution. A random subset (n = 2120 of Danes aged 41-71 years, examined in 1993-1994 for body water distribution by bioelectrical impedance spectroscopy was included. Cox-proportional hazard models and linear splines were performed. The ratio between resistance estimates from an infinite-frequency and from no-frequency (R∞/R0 was used as a surrogate measure of ratio between extracellular water and total body water. The outcome was 13.5 years of follow-up for cardiovascular morbidity and mortality. RESULTS: A high proportion of total body water that is extracellular water was associated with increased risk of incident cardiovascular disease. A threshold effect was evident, with greatly increased risk of cardiovascular morbidity and mortality above R∞/R0 = 0.68. Below the threshold there seemed to be no additional benefit of having a low ratio. CONCLUSION: Our findings suggest that non-clinically evident oedema, measured as an increased proportion of total body water that is extracellular, above a threshold of 0.68, may be an early marker of pre-clinical cardiovascular disease. This simple, safe, cheap and easily obtainable measure of R∞/R0 from bioelectrical impedance may help the early identification of these otherwise clinically healthy individuals who are at an increased risk of future cardiovascular disease

  4. Recording of electrical-evoked responses from a remote field in the vestibular part of the eighth nerve. A preliminary technical report.

    Science.gov (United States)

    Latkowski, B; Puzio, J

    1989-01-01

    The paper discusses the results of the author's own studies concerning the recording of electrical responses evoked from a remote field in the vestibular part of the eighth nerve. The studies are of experimental nature and they were carried out repetitively in guinea pigs. Particular attention is paid to an apparatus specially designed and constructed, permitting to obtain stimulation of adequate quality of vestibular organs, and to receive and average short (up to 10 ms) evoked vestibular potentials. Different variants of elimination of bioelectrical muscular disturbances and of the auditory pathway are proposed.

  5. Treatment of congenital pseudarthrosis of the tibia with direct current.

    Science.gov (United States)

    Lavine, L S; Lustrin, I; Shamos, M H

    1977-05-01

    Bone possesses a bioelectric property that is important in maintaining its structural and architectural integrity. In vivo experiments demonstrate that bone formation can be accelerated by the application of direct current. We hypothesize that bone formation occurs through an electrochemical rather than an electromechanical effect. Two cases of congenital pseudarthrosis of the tibia treated by direct current stimulation are presented. A bone graft may be added to enhance bony union in conjunction with direct current. The implications of this work are that there is need for further fundamental studies including ultrastructural observations.

  6. Validity of dual X-ray absorptiometry scanning for determination of body composition in IDDM patients

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Almdal, T; Gotfredsen, A;

    1995-01-01

    Data on body composition in patients with insulin-dependent diabetes mellitus (IDDM) are scarce. Dual X-ray absorptiometry (DXA) scanning has proved useful for this purpose in other groups of patients. We tested the validity of the DXA scanner for the determination of fat-free mass (FFM) and fat...... mass in IDDM patients and control subjects, as compared to other reference methods, i.e. total body potassium by 40K whole body counting (TBK), total body water by tritiated water (TBW), bioelectrical impedance analysis (BIA) and 24-h urinary creatinine excretion (Ucrea). A total of 13 healthy controls...

  7. Línies de recerca SIC: UB Electrònica

    OpenAIRE

    Cornet i Calveras, Albert; Miribel-Català, Pere Ll.; Rubiralta Casanova, Joan

    2009-01-01

    El departament d'Electrònica té dos grups de RECERCA consolidats, un és el SIC, Sistemes d' Instrumentació i Comunicacions: sensors, micronanosistemes, bioelectrònica i circuits integrats, liderat per en Prof. Josep Samitier i Martí. La seva recerca s'engloba dins el camp de la Mesura i la Instrumentació, amb atenció preferent cap al desenvolupament de MicroNanosistemes. Aquest és un camp de recerca interdisciplinari, que combina tecnologies, estructures, dispositius i algorismes per obtenir ...

  8. Exemples de recerca: UB Electrònica

    OpenAIRE

    Cornet i Calveras, Albert; Miribel-Català, Pere Ll.; Rubiralta Casanova, Joan

    2009-01-01

    El departament d'Electrònica té dos grups de RECERCA consolidats, un és el SIC, Sistemes d' Instrumentació i Comunicacions: sensors, micro@nanosistemes, bioelectrònica i circuits integrats, liderat per en Prof. Josep Samitier i Martí. La seva recerca s'engloba dins el camp de la Mesura i la Instrumentació, amb atenció preferent cap al desenvolupament de Micro@Nanosistemes. Aquest és un camp de recerca interdisciplinari, que combina tecnologies, estructures, dispositius i algorismes per obteni...

  9. Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD

    DEFF Research Database (Denmark)

    Al-shair, Khaled; Dockry, Rachel; Mallia-Milanes, Brendan

    2009-01-01

    BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle...... affect some of the characteristics of depressed patients rather than the prevalence rate of depression. Depression was associated with poor exercise performance and BODE index in COPD....... wasting in clinically stable COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, bioelectrical impedance analysis, 6-minute...

  10. [Nervous system disorders induced by occupational exposure to aluminium compounds: a literature review].

    Science.gov (United States)

    Sińczuk-Walczak, H

    2001-01-01

    This is a review of the literature on the effect of aluminum (Al) and its compounds on the nervous system. The role of aluminum in etiology of some degenerative diseases of the nervous system, e.g. Alzheimer disease, amyotrophic lateral sclerosis or dementia, is presented. The special attention was turned to the effects of aluminum on the nervous system functions in persons occupationally exposed to metal-containing dusts and fumes, manifested mostly by neurobehavioral disorders and changes in the brain bioelectric functions and less frequently pronounced by clinical neurological symptoms.

  11. CHANGES OF SELECTED PHYSIOLOGICAL INDICES IN MEN UNDER THE INFLUENCE OF THERMAL HEATING AND COOLING

    Directory of Open Access Journals (Sweden)

    Prystupa Tetyana

    2010-01-01

    Full Text Available The research objective is defining the influence of exposure to heat during the Finnish sauna treatment in the morning hours on selected physiological indices in men, who were monitored during a series of three sauna treatments in a row. 74 healthy men took part in the studies. Body weight and its composition was diagnosed with the help of TANITA BODY COMPOSITION ANALYZER TBF-300 based on bioelectrical impedance analysis. The conducted research confirm the hypothesis about the positive effect of the Finnish sauna on the body mass components, such as body mass, BMI, TBW (kg and % body fat.

  12. Global power production scenarios to 2100 and the dual role of forests: accelerated climate damage or regulating and provisioning ecosystem services?

    DEFF Research Database (Denmark)

    Callesen, Ingeborg

    on bioelectricity from forest biomass and the associated environmental impacts are outlined using LCA unit process data. The power production is used as a simplified proxy for the global energy supply. It is assumed that the most suitable land under each scenario is reserved for food production, and that changes......, including non-renewable and renewable energy sources, the potential role of forest biomass is investigated. The demands for forest ecosystem services imposed by the global power production are assessed in the present study. Three global power supply scenarios to 2050 with different emphasis...

  13. Acupuncture needles and the Seebeck effect: do temperature gradients produce electrostimulation?

    Science.gov (United States)

    Cohen, M; Kwok, G; Cosic, I

    1997-01-01

    Acupuncture may act through modifying bioelectric events and this may occur through different mechanisms including the application of external currents. According to the Seebeck effect which produces a potential difference when a temperature gradient is placed across a conductor, the physical properties of acupuncture needles may produce internal currents due to the temperature gradient across the needle when placed insitu. Such currents were detected when needles were differentially heated and these currents were found to be in the range capable of producing biological effects. The traditional design of acupuncture needles and traditional needle manipulations seem to maintain a temperature gradient across the needle and thus enhance the Seebeck effect.

  14. Preliminary statistical assessment towards characterization of biobotic control.

    Science.gov (United States)

    Latif, Tahmid; Meng Yang; Lobaton, Edgar; Bozkurt, Alper

    2016-08-01

    Biobotic research involving neurostimulation of instrumented insects to control their locomotion is finding potential as an alternative solution towards development of centimeter-scale distributed swarm robotics. To improve the reliability of biobotic agents, their control mechanism needs to be precisely characterized. To achieve this goal, this paper presents our initial efforts for statistical assessment of the angular response of roach biobots to the applied bioelectrical stimulus. Subsequent findings can help to understand the effect of each stimulation parameter individually or collectively and eventually reach reliable and consistent biobotic control suitable for real life scenarios.

  15. Constitutional and Anatomical Characteristics of Mature Women

    Institute of Scientific and Technical Information of China (English)

    Vladimir NNikolenko; DmitryBNikityuk; SvetlanaVKlochkova; AnastasiaABahmet

    2015-01-01

    Objective To identify the constitutional and anatomical peculiarities of constitution of women of mature age.Methods There was completed comprehensive anthropometric and bio-electrical survey of 651 mature women ( relative norm) living in the Moscow region .Results The quantitative distribution of women by somatotypological affiliation was revealed;anthropometric and body component composition in representatives of different somatotypes were defined .Conclusion Thus, the performed study revealed and quantiely character-ised the distribution of women according to their constitutional types in the studied population of mature age women living in Moscow region under the relative norm conditions .

  16. Molecular ferroelectrics: where electronics meet biology.

    Science.gov (United States)

    Li, Jiangyu; Liu, Yuanming; Zhang, Yanhang; Cai, Hong-Ling; Xiong, Ren-Gen

    2013-12-28

    In the last several years, we have witnessed significant advances in molecular ferroelectrics, with the ferroelectric properties of molecular crystals approaching those of barium titanate. In addition, ferroelectricity has been observed in biological systems, filling an important missing link in bioelectric phenomena. In this perspective, we will present short historical notes on ferroelectrics, followed by an overview of the fundamentals of ferroelectricity. The latest developments in molecular ferroelectrics and biological ferroelectricity will then be highlighted, and their implications and potential applications will be discussed. We close by noting molecular ferroelectric as an exciting frontier between electronics and biology, and a number of challenges ahead are also described.

  17. Experimental study of effectiveness of local application of electroneurostimulation, cortexin and methylprednisolone in acute spinal cord injury

    Directory of Open Access Journals (Sweden)

    Tsymbaliuk V.I.

    2014-09-01

    Full Text Available The tasks were to investigate the effect of topical electroneurostimulation, cortexin and methy¬lprednisolone in acute spinal cord injury in electrophysiological experiments on laboratory rats. The animals un¬derwent half transection of the spinal cord in the lower-thoracic area to simulate Brown-Sequard’s syndrome. Drugs were administered subdurally once daily in the dose of 0.03 mg for cortexin and 0.7 mg for methylprednisolone during 72 hours. Electrophysiological studies were carried out using standard electrophysiological apparatus. Reliable changes of bioelectric indicators in neuromuscular complex during topical application of electrical stimulation, as well as in administered methylprednisolone, failed to be found. However, local application of cortexin in terms of traumatic spinal cord injury due the antioxidant and neurotrophic effect results in improvement of bioelectrical indicators; this is manifested in reliable (p<0.05 increase of amplitude of the background electromyogram impulses at rest by 33% and increase of spontaneous oscillations frequency by 29.82%.

  18. Newton-Krylov-BDDC solvers for nonlinear cardiac mechanics

    KAUST Repository

    Pavarino, L.F.

    2015-07-18

    The aim of this work is to design and study a Balancing Domain Decomposition by Constraints (BDDC) solver for the nonlinear elasticity system modeling the mechanical deformation of cardiac tissue. The contraction–relaxation process in the myocardium is induced by the generation and spread of the bioelectrical excitation throughout the tissue and it is mathematically described by the coupling of cardiac electro-mechanical models consisting of systems of partial and ordinary differential equations. In this study, the discretization of the electro-mechanical models is performed by Q1 finite elements in space and semi-implicit finite difference schemes in time, leading to the solution of a large-scale linear system for the bioelectrical potentials and a nonlinear system for the mechanical deformation at each time step of the simulation. The parallel mechanical solver proposed in this paper consists in solving the nonlinear system with a Newton-Krylov-BDDC method, based on the parallel solution of local mechanical problems and a coarse problem for the so-called primal unknowns. Three-dimensional parallel numerical tests on different machines show that the proposed parallel solver is scalable in the number of subdomains, quasi-optimal in the ratio of subdomain to mesh sizes, and robust with respect to tissue anisotropy.

  19. Role of macrophyte and effect of supplementary aeration in up-flow constructed wetland-microbial fuel cell for simultaneous wastewater treatment and energy recovery.

    Science.gov (United States)

    Oon, Yoong-Ling; Ong, Soon-An; Ho, Li-Ngee; Wong, Yee-Shian; Dahalan, Farrah Aini; Oon, Yoong-Sin; Lehl, Harvinder Kaur; Thung, Wei-Eng; Nordin, Noradiba

    2017-01-01

    This study investigates the role of plant (Elodea nuttallii) and effect of supplementary aeration on wastewater treatment and bioelectricity generation in an up-flow constructed wetland-microbial fuel cell (UFCW-MFC). Aeration rates were varied from 1900 to 0mL/min and a control reactor was operated without supplementary aeration. 600mL/min was the optimum aeration flow rate to achieve highest energy recovery as the oxygen was sufficient to use as terminal electron acceptor for electrical current generation. The maximum voltage output, power density, normalized energy recovery and Coulombic efficiency were 545.77±25mV, 184.75±7.50mW/m(3), 204.49W/kg COD, 1.29W/m(3) and 10.28%, respectively. The variation of aeration flow rates influenced the NO3(-) and NH4(+) removal differently as nitrification and denitrification involved conflicting requirement. In terms of wastewater treatment performance, at 60mL/min aeration rate, UFCW-MFC achieved 50 and 81% of NO3(-) and NH4(+) removal, respectively. E. nuttallii enhanced nitrification by 17% and significantly contributed to bioelectricity generation.

  20. Comparative efficiency and driving range of light- and heavy-duty vehicles powered with biomass energy stored in liquid fuels or batteries.

    Science.gov (United States)

    Laser, Mark; Lynd, Lee R

    2014-03-04

    This study addresses the question, "When using cellulosic biomass for vehicular transportation, which field-to-wheels pathway is more efficient: that using biofuels or that using bioelectricity?" In considering the question, the level of assumed technological maturity significantly affects the comparison, as does the intended transportation application. Results from the analysis indicate that for light-duty vehicles, over ranges typical in the United States today (e.g., 560-820 miles), field-to-wheels performance is similar, with some scenarios showing biofuel to be more efficient, and others indicating the two pathways to be essentially the same. Over the current range of heavy-duty vehicles, the field-to-wheels efficiency is higher for biofuels than for electrically powered vehicles. Accounting for technological advances and range, there is little basis to expect mature bioelectricity-powered vehicles to have greater field-to-wheels efficiency (e.g., kilometers per gigajoule biomass or per hectare) compared with mature biofuel-powered vehicles.

  1. Dark fermentation, anaerobic digestion and microbial fuel cells: An integrated system to valorize swine manure and rice bran.

    Science.gov (United States)

    Schievano, Andrea; Sciarria, Tommy Pepè; Gao, Yong Chang; Scaglia, Barbara; Salati, Silvia; Zanardo, Marina; Quiao, Wei; Dong, Renjie; Adani, Fabrizio

    2016-10-01

    This work describes how dark fermentation (DF), anaerobic digestion (AD) and microbial fuel cells (MFC) and solid-liquid separation can be integrated to co-produce valuable biochemicals (hydrogen and methane), bioelectricity and biofertilizers. Two integrated systems (System 1: AD+MFC, and System 2: DF+AD+MFC) are described and compared to a traditional one-stage AD system in converting a mixture (COD=124±8.1gO2kg(-1)Fresh Matter) of swine manure and rice bran. System 1 gave a biomethane yield of 182 LCH4kg(-1)COD-added, while System 2 gave L yields of bio-hydrogen and bio-methane of 27.3±7.2LH2kg(-1)COD-added and 154±14LCH4kg(-1)COD-added, respectively. A solid-liquid separation (SLS) step was applied to the digested slurry, giving solid and liquid fractions. The liquid fraction was treated via the MFC-steps, showing power densities of 12-13Wm(-3) (500Ω) and average bioelectricity yields of 39.8Whkg(-1)COD to 54.2Whkg(-1)COD.

  2. Solution space reduction in the peripheral nerve source localization problem using forward field similarities

    Science.gov (United States)

    Zariffa, José; Popovic, Milos R.

    2008-06-01

    Improving our ability to localize bioelectric sources within a peripheral nerve would help us to monitor the control signals flowing to and from any limb or organ. This technology would provide a useful neuroscience tool, and could perhaps be incorporated into a neuroprosthesis interface. We propose to use measurements from a multi-contact nerve cuff to solve an inverse problem of bioelectric source localization within the peripheral nerve. Before the inverse problem can be addressed, the forward problem is solved using finite element modeling. A fine mesh improves the accuracy of the forward problem solution, but increases the number of variables to be solved for in the inverse problem. To alleviate this problem, variables corresponding to mesh elements that are not distinguishable by the measurement setup are grouped together, thus reducing the dimension of the inverse problem without impacting on the forward problem accuracy. A quantitative criterion for element distinguishability is derived using the columns of the leadfield matrix and information about the uncertainty in the measurements. Our results indicate that the number of variables in the inverse problem can be reduced by more than half using the proposed method, without having a detrimental impact on the quality of the localization.

  3. Nitrate removal and bioenergy production in constructed wetland coupled with microbial fuel cell: Establishment of electrochemically active bacteria community on anode.

    Science.gov (United States)

    Wang, Junfeng; Song, Xinshan; Wang, Yuhui; Abayneh, Befkadu; Li, Yihao; Yan, Denghua; Bai, Junhong

    2016-12-01

    The constructed wetland coupled with microbial fuel cell (CW-MFC) systems operated at different substrate concentration and pH influents were evaluated for bioelectricity generation, contaminant removal and microbial community structure. Performance of CW-MFC was evaluated at organic loading rate of 75.3gCODm(-3)d(-1) and pH gradients of (5.18±0.14, 7.31±0.13, and 8.75±0.12) using carbon fiber felt as electrodes. Peak power density was observed at slightly neutral influent condition. Compared with the open circuit CW-MFC, average COD and NO3-N removal efficiency in CW-MFC increased by 8.3% and 40.2% respectively under slightly neutral pH of influents. However, the removal efficiency and bioenergy production have been inhibited with acidic influents. The relative abundance of beta-Proteobacteria, nitrobacteria and denitrifying bacteria was significantly promoted in closed-circuit CW-MFC. Using of CW-MFC as a biochemical method for nitrate removal and bioelectricity generation under slightly neutral and alkaline influent conditions was a promising technology.

  4. Nutritional status using multidimensional assessment in Iranian elderly

    Directory of Open Access Journals (Sweden)

    Yahya Pasdar

    2011-07-01

    Full Text Available Background: Nutrition is an important determinant of health in elderly and nutritional assessment is necessary for development of treatment protocols. The study aimed to evaluate nutritional status using multidimensional assessment in elderly.Methods: One hundred fourteen subjects (76 men and 64 women from elderly residence house in Kermanshah, Western Iran were studied. Data was collected using Mini-Nutritional Assessment (MNA, FFQ, anthropometry, bioelectric impedance, biochemistry tools. Hematologic and biochemistry markers were assessed in 5 ml fasting blood sample. Results: 46.4% showed normal nutritional status while 38.7% have been classified as mild to moderate malnutrition and 14.9% suffered from severe malnutrition based on MNA scores. Malnutrition using different cut-offs were; body mass index 16.4%, haemoglobin 19%, albumin (with normal CRP level 9.8%, ferritin 9.4% (<20 µg/l. Lean body mass and percent of body fat was lower than normal in 23% and 21% respectively. There was significant correlation between lean body mass, total body water and MNA score (p<0.05. A strong positive correlation was found between; BMI, percent of body fat, Mid arm circumference and MNA total score (p<0.001. Conclusion: The study confirmed that MNA score was significantly associated with anthropometric, bioelectric and biochemical findings. It is concluded that an appropriate nutrition intervention program need to introduce to improve nutritional status in older people living in elderly homes.

  5. Learning to modulate the partial powers of a single sEMG power spectrum through a novel human-computer interface.

    Science.gov (United States)

    Skavhaug, Ida-Maria; Lyons, Kenneth R; Nemchuk, Anna; Muroff, Shira D; Joshi, Sanjay S

    2016-06-01

    New human-computer interfaces that use bioelectrical signals as input are allowing study of the flexibility of the human neuromuscular system. We have developed a myoelectric human-computer interface which enables users to navigate a cursor to targets through manipulations of partial powers within a single surface electromyography (sEMG) signal. Users obtain two-dimensional control through simultaneous adjustments of powers in two frequency bands within the sEMG spectrum, creating power profiles corresponding to cursor positions. It is unlikely that these types of bioelectrical manipulations are required during routine muscle contractions. Here, we formally establish the neuromuscular ability to voluntarily modulate single-site sEMG power profiles in a group of naïve subjects under restricted and controlled conditions using a wrist muscle. All subjects used the same pre-selected frequency bands for control and underwent the same training, allowing a description of the average learning progress throughout eight sessions. We show that subjects steadily increased target hit rates from 48% to 71% and exhibited greater control of the cursor's trajectories following practice. Our results point towards an adaptable neuromuscular skill, which may allow humans to utilize single muscle sites as limited general-purpose signal generators. Ultimately, the goal is to translate this neuromuscular ability to practical interfaces for the disabled by using a spared muscle to control external machines.

  6. Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Renne, Walter George; Mennito, Anthony Samuel; Schmidt, Michael Gerard; Vuthiganon, Jompobe; Chumanov, George

    2015-05-19

    Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu.sup.0, Cu.sup.1+, Cu.sup.2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria. The presence of CuQ results in inhibiting or delaying bacterial destruction and endogenous enzymatic breakdown of the zone of resin inter-diffusion, the integrity of which is essential for dental restoration longevity.

  7. Sustainable power generation from floating macrophytes based ecological microenvironment through embedded fuel cells along with simultaneous wastewater treatment.

    Science.gov (United States)

    Venkata Mohan, S; Mohanakrishna, G; Chiranjeevi, P

    2011-07-01

    Miniatured floating macrophyte based ecosystem (FME) designed with Eichornia as the major biota was evaluated for bioelectricity generation and wastewater treatment. Three fuel cell assemblies (non-catalyzed electrodes) embedded in FME were evaluated with domestic sewage and fermented distillery wastewater in continuous mode for 210 days. Fermented distillery effluents from biohydrogen production (dark-fermentation) process exhibited effective power generation with simultaneous waste remediation. Two fuel cell assemblies (A1 and A2) showed effective bioelectricity generation. Increasing the organic load of wastewater showed good correlation with both power generation (A1, 211.14 mA/m(2); A2, 224.93 mA/m(2)) and wastewater treatment (COD removal, 86.67% and VFA removal 72.32%). Combining A1 and A2 assemblies depicted stabilized performance with respect to current and voltage along with significant decrease in ohmic and activation losses. FME also exhibited effective removal of nitrates, colour and turbidity from wastewater. The studied miniatured ecological system facilitates both energy generation and wastewater treatment with a sustainable perspective.

  8. Differential Effect of Isooctane Doses on HaCaT and HeLa: A Multimodal Analysis

    Directory of Open Access Journals (Sweden)

    Lopamudra Das

    2014-01-01

    Full Text Available A multimodal approach is effective in analyzing biological problems critically and thus also useful in assessing cytotoxicity under chemicals assaults. In this study effects of isooctane, an organic solvent and component of gasoline produced in petroleum industries, have been explored on normal (HaCaT and cancerous (HeLa epithelial cells. Besides morphological alterations, impacts on viability, prime molecular expressions, and bioelectrical properties on exposure to different doses of isooctane were noted. Scanning electron microscopy and viability assay demonstrated remarkable structural alterations and cell death, respectively, in HaCaT but not in HeLa. Transcriptomic and immunocytochemical studies on E-cadherin expression also elucidated pronounced toxic effects on HaCaT. Remarkable changes on the bioelectrical properties (e.g., impedance and phase angle of the HaCaT, in contrast to HeLa, at different temporal points on isooctane exposure also indicated cytotoxic effects in the former. Hence this study illustrated cytotoxicity of isooctane on HaCaT multidimensionally which was evaded by HeLa.

  9. Perioperative nutritional therapy in liver transplantation.

    Science.gov (United States)

    Hammad, Ahmed; Kaido, Toshimi; Uemoto, Shinji

    2015-03-01

    Protein-energy malnutrition is frequently seen in patients with end-stage liver disease who undergo liver transplantation. This causes a deterioration of the patients' clinical condition and affects their post-transplantation survival. Accurate assessment of the nutritional status and adequate intervention are prerequisites for perioperative nutritional treatment. However, the metabolic abnormalities induced by liver failure make the traditional assessment of the nutritional status difficult. The methods that were recently developed for accurately assessing the nutritional status by body bioelectrical impedance may be implemented in pre-transplant management. Because preoperative malnutrition and the loss of skeletal muscle mass, called sarcopenia, have a significant negative impact on the post-transplantation outcome, it is essential to provide adequate nutritional support during all phases of liver transplantation. Oral nutrition is preferred, but tube enteral nutrition may be required to provide the necessary caloric intake. We herein discuss both bioelectrical impedance and the latest findings in the current perioperative nutritional interventions in liver transplant patients regarding synbiotics, micronutrients, branched-chain amino acid supplementation, the use of immune system modulating formulas, the fluid balance and the offering of nocturnal meals.

  10. Lower lean mass and higher percent fat mass in patients with Alzheimer's disease.

    Science.gov (United States)

    Buffa, R; Mereu, E; Putzu, P; Mereu, R M; Marini, E

    2014-10-01

    In this study we analyzed body composition in relation to cognitive and functional status, in a cross-sectional sample of patients with Alzheimer's disease (AD). Seventy individuals (27 men, 78.1±6.5years; 43 women, 80.4±5.6years) with mild-moderate stages of AD (clinical dementia ratings 1 and 2) were selected from the Alzheimer Center, SS. Trinità Hospital, ASL 8 of Cagliari (Italy). Cognitive and psycho-functional status was evaluated using mini-mental state examination (MMSE), activities of daily living (ADL) scale, and geriatric depression scale (GDS). Mini-nutritional assessment (MNA) was applied. Anthropometric measurements were taken and body mass index (BMI) was calculated. Body composition was assessed by means of specific bioelectrical impedance vector analysis (BIVA), using the references for the elderly. In comparison with the reference group, patients with AD showed similar BMI and MNA, but peculiar bioelectrical characteristics: lower phase angles and longer vectors (pnutritional status.

  11. Nutritional assessment methods for zinc supplementation in prepubertal non-zinc-deficient children

    Directory of Open Access Journals (Sweden)

    Márcia Marília Gomes Dantas Lopes

    2015-10-01

    Full Text Available Background: Zinc is an essential nutrient that is required for numerous metabolic functions, and zinc deficiency results in growth retardation, cell-mediated immune dysfunction, and cognitive impairment. Objective: This study evaluated nutritional assessment methods for zinc supplementation in prepubertal non-zinc-deficient children. Design: We performed a randomised, controlled, triple-blind study. The children were divided into a control group (10% sorbitol, n=31 and an experimental group (10 mg Zn/day, n=31 for 3 months. Anthropometric and dietary assessments as well as bioelectrical measurements were performed in all children. Results: Our study showed (1 an increased body mass index for age and an increased phase angle in the experimental group; (2 a positive correlation between nutritional assessment parameters in both groups; (3 increased soft tissue, and mainly fat-free mass, in the body composition of the experimental group, as determined using bioelectrical impedance vector analysis; (4 increased consumption of all nutrients, including zinc, in the experimental group; and (5 an increased serum zinc concentration in both groups (p<0.0001. Conclusions: Given that a reference for body composition analysis does not exist for intervention studies, longitudinal studies are needed to investigate vector migration during zinc supplementation. These results reinforce the importance of employing multiple techniques to assess the nutritional status of populations.

  12. TrkB-Mediated Neuroprotective and Antihypoxic Properties of Brain-Derived Neurotrophic Factor.

    Science.gov (United States)

    Vedunova, Maria V; Mishchenko, Tatiana A; Mitroshina, Elena V; Mukhina, Irina V

    2015-01-01

    The neuroprotective and antihypoxic effects of brain-derived neurotrophic factor (BDNF) on dissociated hippocampal cultures in a hypoxia model were investigated. These experiments demonstrate that 10 minutes of normobaric hypoxia increased the number of dead cells in primary culture, whereas a preventive application of BDNF increased the number of viable cells. Spontaneous bioelectrical and calcium activity in neural networks was analyzed using multielectrode arrays and functional intravital calcium imaging. The results indicate that BDNF affects the functional parameters of neuronal networks in dissociated hippocampal cultures over the 7-day posthypoxic period. In addition, the effects of k252a, an antagonist of tropomyosin-related kinase B (TrkB), on functional bioelectrical activity during and after acute hypoxia were investigated. It was shown that the protective effects of BDNF are associated with binding to the TrkB receptor. Finally, intravital fluorescent mRNA probes were used to study the role of NF-κB1 in the protective effects of BDNF. Our experiments revealed that BDNF application stimulates NF-κB1 mRNA synthesis in primary dissociated hippocampal cells under normal conditions but not in hypoxic state.

  13. A Fast Framework for Abrupt Change Detection Based on Binary Search Trees and Kolmogorov Statistic.

    Science.gov (United States)

    Qi, Jin-Peng; Qi, Jie; Zhang, Qing

    2016-01-01

    Change-Point (CP) detection has attracted considerable attention in the fields of data mining and statistics; it is very meaningful to discuss how to quickly and efficiently detect abrupt change from large-scale bioelectric signals. Currently, most of the existing methods, like Kolmogorov-Smirnov (KS) statistic and so forth, are time-consuming, especially for large-scale datasets. In this paper, we propose a fast framework for abrupt change detection based on binary search trees (BSTs) and a modified KS statistic, named BSTKS (binary search trees and Kolmogorov statistic). In this method, first, two binary search trees, termed as BSTcA and BSTcD, are constructed by multilevel Haar Wavelet Transform (HWT); second, three search criteria are introduced in terms of the statistic and variance fluctuations in the diagnosed time series; last, an optimal search path is detected from the root to leaf nodes of two BSTs. The studies on both the synthetic time series samples and the real electroencephalograph (EEG) recordings indicate that the proposed BSTKS can detect abrupt change more quickly and efficiently than KS, t-statistic (t), and Singular-Spectrum Analyses (SSA) methods, with the shortest computation time, the highest hit rate, the smallest error, and the highest accuracy out of four methods. This study suggests that the proposed BSTKS is very helpful for useful information inspection on all kinds of bioelectric time series signals.

  14. [Transcranial magnetic electro-stimulation with alternate action on brain hemispheres in the correction of cerebral disturbances in children with diabetes mellitus type 1].

    Science.gov (United States)

    Filina, N Iu; Bolotova, N V; Raĭgorodskiĭ, Iu M; Nikolaeva, N V

    2012-01-01

    Correction of psychoemotional and autonomic disturbances in children 7-17 years old with diabetes mellitus type 1 was conducted using transcranial magnetic electro-stimulation with alternate action on brain hemispheres (main group, 42 patients). The method includes the combined action of magnetic field pulses and series of electric impulses; magnetic and electric stimulation were performed synchronously - at first, on one brain hemisphere, then on another hemisphere with alternation frequency 9.5-10.5 Hz. A comparison group consisted of 44 patients with diabetes mellitus type 1 who received physiotherapeutic treatment as a combination of transcranial magnetic therapy and electro-stimulation with simultaneous action on both brain hemispheres. Treatment duration was 10 sessions. Treatment efficacy was assessed by the decrease in frequency and intensity of complaints, improvement of patient's health status measured (a scale for assessment of activity, health perception and mood) and improvement of the status of the autonomic nervous system (Vein's questionnaire), mental sphere (the Luscher color test) and cognitive traits (The Concentrated Attention Test of the Toulouse-Pierron Factorial Battery). The status of the autonomic nervous system was evaluated before and after the treatment using cardiointervalography. Brain bioelectrical activity was assessed using encephalography. Significant reduction of autonomic, psychoemotional and cognitive disturbances, normalization of brain bioelectrical activity due to the α-rhythm organization and arrhythmia removal were identified in the main group after the treatment. No adverse effects of this physiotherapeutic treatment was found.

  15. Nanodevices based on Membrane-Carbon Nanotube Hybrid Structures

    Science.gov (United States)

    Jin, Hye Jun; Kim, Tae Hyun; Namgung, Seon; Hong, Seunghun; Lee, Sang Hun; Park, Tai Hyun

    2010-03-01

    Proteins in cell membrane have been drawing attention due to their versatile functionalities such as ion transfer for neuronal activity and selective binding for sensory systems. However, it is still very difficult to manipulate and study those proteins because they easily lose their functionalities without lipid membranes. We developed a method to coat lipid membranes containing various functional membrane proteins on single-walled carbon nanotube (swCNT)-based field effect transistors (FETs). In this hybrid structure, the activity of membrane proteins can be monitored by underlying swCNT-FETs, allowing us to easily study the functionalities of membrane proteins. Furthermore, we built advanced devices based on these hybrid structures. For an example, we coated lipid membrane containing `olfactory receptors' on swCNT-FETs, resulting in `bioelectric nose' systems. The bioelectric nose system had high sensitivity and human nose-like selectivity to odorant molecules. This talk will also discuss about the future prospect of these membrane-CNT hybrid structures.

  16. Large naturally-produced electric currents and voltage traverse damaged mammalian spinal cord

    Directory of Open Access Journals (Sweden)

    Borgens Richard B

    2008-12-01

    Full Text Available Abstract Background Immediately after damage to the nervous system, a cascade of physical, physiological, and anatomical events lead to the collapse of neuronal function and often death. This progression of injury processes is called "secondary injury." In the spinal cord and brain, this loss in function and anatomy is largely irreversible, except at the earliest stages. We investigated the most ignored and earliest component of secondary injury. Large bioelectric currents immediately enter damaged cells and tissues of guinea pig spinal cords. The driving force behind these currents is the potential difference of adjacent intact cell membranes. For perhaps days, it is the biophysical events caused by trauma that predominate in the early biology of neurotrauma. Results An enormous (≤ mA/cm2 bioelectric current transverses the site of injury to the mammalian spinal cord. This endogenous current declines with time and with distance from the local site of injury but eventually maintains a much lower but stable value (2. The calcium component of this net current, about 2.0 pmoles/cm2/sec entering the site of damage for a minimum of an hour, is significant. Curiously, injury currents entering the ventral portion of the spinal cord may be as high as 10 fold greater than those entering the dorsal surface, and there is little difference in the magnitude of currents associated with crush injuries compared to cord transection. Physiological measurements were performed with non-invasive sensors: one and two-dimensional extracellular vibrating electrodes in real time. The calcium measurement was performed with a self-referencing calcium selective electrode. Conclusion The enormous bioelectric current, carried in part by free calcium, is the major initiator of secondary injury processes and causes significant damage after breach of the membranes of vulnerable cells adjacent to the injury site. The large intra-cellular voltages, polarized along the length of

  17. Chronic depression treated successfully with novel taping therapy: a new approach to the treatment of depression

    Directory of Open Access Journals (Sweden)

    Han CH

    2016-06-01

    sense of calmness following the first treatment and recovered from her symptoms after 2 weeks.Conclusion: These results suggest the following key points: examination of acupoints and trigger points of chest, sides, and upper back is useful in the assessment of depression; regulating bioelectric currents on these points is helpful in the treatment of depression; and depression can be treated successfully with taping therapy. Keywords: fatigue, insomnia, bioelectricity, bioelectric current, acupoint, trigger point

  18. Experience with a Fourier method for determining the extracellular potential fields of excitable cells with cylindrical geometry.

    Science.gov (United States)

    Clark, J W; Greco, E C; Harman, T L

    1978-11-01

    In this chapter, well-known solutions that utilize a Fourier transform method for determining the extracellular, volume-conductor potential distribution surrounding elongated excitable cells of cylindrical geometry are reformulated as a discrete Fourier transform (DFT) problem, which subsequently permits the volume-conductor problem to be viewed as an equivalent linear-filtering problem. This DFT formulation is fast and computationally efficient. In addition, it lends itself to the application of some rather well-known techniques in linear systems theory (e.g., the DFT for convolution and least mean-square (Wiener) filtering for optimal prediction of a signal in random noise). Two specific examples are employed to demonstrate the utility of this discrete Fourier method: (1) the single, isolated, active nerve fiber in an essentially infinite volume conductor and (2) the isolated, active nerve trunk in a similar type of extracellular medium. In each of these, our DFT method is employed to obtain both the classical "forward" and "inverse" potential solutions for each volume conductor problem. In the case where the single, active nerve fiber is the bioelectric source in the volume conductor, simulated action-potential data from an invertebrate giant axon is utilized, and potentials at various points in the extracellular medium are calculated. The calculated potential distributions in axial distance z, at various radial distances r, are consistent with well-known experimental fact. When the active nerve trunk acts as the bioelectric source, the DFT method provides calculated potential distributions that are fairly consistent with experimental data under a variety of experimental conditions. For example, in these experiments, a special, isolated frog spinal cord preparation is used that permits separate or combined stimulation of the motor and sensory nerve fiber components of the attached sciatic nerve trunk. By manipulating the stimulus intensity applied to the motor

  19. Relationship between lower limb position and pelvic floor muscle surface electromyography activity in menopausal women: a prospective observational study

    Science.gov (United States)

    Halski, Tomasz; Ptaszkowski, Kuba; Słupska, Lucyna; Dymarek, Robert; Paprocka-Borowicz, Małgorzata

    2017-01-01

    Objectives In physiotherapeutic practice, special attention is being given to the reciprocal anatomical, physiological, and biomechanical relationship of the pelvis and the structures connected to it. However, the scientific literature shows mainly the theoretical information about their mutual connections. The lack of information about these relations from a practical aspect coupled with the paucity of scientific papers on the impact of posture changes on the pelvic floor led the authors to conduct this study. The primary aim of this study was to compare the resting and functional bioelectrical activities of pelvic floor muscles (PFMs) depending on three different positions of the lower limbs (positions A, B, and C) in the supine position. Materials and methods This was a prospective observational study evaluating resting and functional activities of the PFM depending on the position of the lower limbs. The study was carried out at the Department and Clinic of Urology, University Hospital in Wroclaw, Poland and the target group were women in the menopausal period. Bioelectrical activity of PFM was recorded using a surface electromyographic instrument in the supine position. Results of the values obtained in A, B, and C positions were compared using a one-way analysis of variance. Results In position A, the average resting surface electromyography (sEMG) activity of PFM was 6.9±2.6 µV; in position B, the result was 6.9±2.5 µV and in position C, the resting sEMG activity was 5.7±1.8 µV (P=0.0102). The results of the functional bioelectrical activity of PFM were as follows: position A – 20.3±11.8 µV, position B – 19.9±10.6 µV, and position C – 25.3±10.9 µV (P=0.0104). Conclusion The results showed that in the supine position, the PFM achieved the lowest resting activity and the highest functional activity. Therefore, the supine position can be recommended for the diagnosis and therapy of weakened PFM. PMID:28115836

  20. Relationship between lower limb position and pelvic floor muscle surface electromyography activity in menopausal women: a prospective observational study

    Directory of Open Access Journals (Sweden)

    Halski T

    2017-01-01

    Full Text Available Tomasz Halski,1 Kuba Ptaszkowski,2 Lucyna Słupska,1 Robert Dymarek,3 Małgorzata Paprocka-Borowicz2 1Department of Physiotherapy, Opole Medical School, Opole, 2Department of Clinical Biomechanics and Physiotherapy in Motor System Disorders, 3Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland Objectives: In physiotherapeutic practice, special attention is being given to the reciprocal anatomical, physiological, and biomechanical relationship of the pelvis and the structures connected to it. However, the scientific literature shows mainly the theoretical information about their mutual connections. The lack of information about these relations from a practical aspect coupled with the paucity of scientific papers on the impact of posture changes on the pelvic floor led the authors to conduct this study. The primary aim of this study was to compare the resting and functional bioelectrical activities of pelvic floor muscles (PFMs depending on three different positions of the lower limbs (positions A, B, and C in the supine position.Materials and methods: This was a prospective observational study evaluating resting and functional activities of the PFM depending on the position of the lower limbs. The study was carried out at the Department and Clinic of Urology, University Hospital in Wroclaw, Poland and the target group were women in the menopausal period. Bioelectrical activity of PFM was recorded using a surface electromyographic instrument in the supine position. Results of the values obtained in A, B, and C positions were compared using a one-way analysis of variance.Results: In position A, the average resting surface electromyography (sEMG activity of PFM was 6.9±2.6 µV; in position B, the result was 6.9±2.5 µV and in position C, the resting sEMG activity was 5.7±1.8 µV (P=0.0102. The results of the functional bioelectrical activity of PFM were as follows: position A – 20.3

  1. Body Composition Changes Associated With Methadone Treatment

    Directory of Open Access Journals (Sweden)

    Sadek

    2016-02-01

    Full Text Available Background Methadone is associated with a statistically significant increase in BMI in the first 2 years of treatment. Objectives To evaluate the changes of body composition (bone mass, % fat, % muscle mass, % water, and basal metabolic rate related to this increase. Patients and Methods Changes in body composition were monitored, via bioelectrical impedance, in 29 patients in methadone treatment for opiate dependency (age 18 to 44, mean = 29.3, SD = 7.0, 13 men, 16 women. Results Within one year from admission to treatment, a statistically significant (t-tests, P < 0.05 increase was noted in their body mass index (BMI, % of body fat, average body mass, and average basal metabolic rate, and relative decrease in their % of muscle mass and % of bone mass. Neither absolute bone mass nor muscle mass changed significantly. Conclusions Physicians involved in care of methadone patients should recommend dietary and lifestyle changes to improve their overall health.

  2. A Nanosecond Pulsed Plasma Brush for Surface Decontamination

    Science.gov (United States)

    Neuber, Johanna; Malik, Muhammad; Song, Shutong; Jiang, Chunqi

    2015-11-01

    This work optimizes a non-thermal, atmospheric pressure plasma brush for surface decontamination. The generated plasma plumes with a maximum length of 2 cm are arranged in a 5 cm long, brush-like array. The plasma was generated in ambient air with plasma chamber at a rate varying between 1 to 7 SLPM. Optimization of the cold plasma brush for surface decontamination was tested in a study of the plasma inactivation of two common pathogens, Staphylococcus aureus and Acinetobacter baumannii. Laminate surfaces inoculated with over-night cultured bacteria were subject to the plasma treatment for varying water concentrations in He, flow rates and discharge voltages. It was found that increasing the water content of the feed gas greatly enhanced the bactericidal effect. Emission spectroscopy was performed to identify the reactive plasma species that contribute to this variation. Additional affiliation: Frank Reidy Research Center for Bioelectrics

  3. Microbial community structure of different electrode materials in constructed wetland incorporating microbial fuel cell.

    Science.gov (United States)

    Wang, Junfeng; Song, Xinshan; Wang, Yuhui; Abayneh, Befkadu; Ding, Yi; Yan, Denghua; Bai, Junhong

    2016-12-01

    The microbial fuel cell coupled with constructed wetland (CW-MFC) microcosms were operated under fed-batch mode for evaluating the effect of electrode materials on bioelectricity generation and microbial community composition. Experimental results indicated that the bioenergy output in CW-MFC increased with the substrate concentration; maximum average voltage (177mV) was observed in CW-MFC with carbon fiber felt (CFF). In addition, the four different materials resulted in the formation of significantly different microbial community distribution around the anode electrode. The relative abundance of Proteobacteria in CFF and foamed nickel (FN) was significantly higher than that in stainless steel mesh (SSM) and graphite rod (GR) samples. Notably, the findings indicate that CW-MFC utilizing FN anode electrode could apparently improve relative abundance of Dechloromonas, which has been regarded as a denitrifying and phosphate accumulating microorganism.

  4. Two stage bioethanol refining with multi litre stacked microbial fuel cell and microbial electrolysis cell.

    Science.gov (United States)

    Sugnaux, Marc; Happe, Manuel; Cachelin, Christian Pierre; Gloriod, Olivier; Huguenin, Gérald; Blatter, Maxime; Fischer, Fabian

    2016-12-01

    Ethanol, electricity, hydrogen and methane were produced in a two stage bioethanol refinery setup based on a 10L microbial fuel cell (MFC) and a 33L microbial electrolysis cell (MEC). The MFC was a triple stack for ethanol and electricity co-generation. The stack configuration produced more ethanol with faster glucose consumption the higher the stack potential. Under electrolytic conditions ethanol productivity outperformed standard conditions and reached 96.3% of the theoretically best case. At lower external loads currents and working potentials oscillated in a self-synchronized manner over all three MFC units in the stack. In the second refining stage, fermentation waste was converted into methane, using the scale up MEC stack. The bioelectric methanisation reached 91% efficiency at room temperature with an applied voltage of 1.5V using nickel cathodes. The two stage bioethanol refining process employing bioelectrochemical reactors produces more energy vectors than is possible with today's ethanol distilleries.

  5. Road Traffic and Railway Noise Exposures and Adiposity in Adults

    DEFF Research Database (Denmark)

    Christensen, Jeppe Schultz; Raaschou-Nielsen, Ole; Tjønneland, Anne

    2016-01-01

    BACKGROUND: Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES: We aimed to investigate the relationship between residential traffic...... and railway noise and adiposity. METHODS: In this cross-sectional study of 57,053 middle-aged people, height, weight, waist circumference, and bioelectrical impedance were measured at enrollment (1993-1997). Body mass index (BMI), body fat mass index (BFMI), and lean body mass index (LBMI) were calculated....... Residential exposure to road and railway traffic noise exposure was calculated using the Nordic prediction method. Associations between traffic noise and anthropometric measures at enrollment were analyzed using general linear models and logistic regression adjusted for demographic and lifestyle factors...

  6. Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study

    DEFF Research Database (Denmark)

    Stegger, J G; Schmidt, E B; Obel, T

    2011-01-01

    distribution.Methods and results:From 1993 to 1997, 27¿148 men and 29¿863 women, aged 50 to 64 year, were recruited into the Danish prospective study Diet, Cancer and Health. During 11.9 years of follow-up we identified 2028 cases of incident MI (1487 men and 541 women). BMI, waist circumference (WC), hip......Introduction:Obesity is a modifiable risk factor for acute myocardial infarction (MI), but lean body mass (LBM) may also be an important factor. Low LBM may increase the risk of MI and LBM may modify the effect of obesity on MI. Thus, the inability of the classical anthropometric measures...... to evaluate LBM may lead to misclassification of MI risk in both lean and obese persons. We investigated the associations between incident MI and bioelectrical impedance analyses (BIA) derived measures of body composition in combination with body mass index (BMI) and anthropometric measures of body fat...

  7. Changes in body water distribution during treatment with inhaled steroid in pre-school children

    DEFF Research Database (Denmark)

    Heitmann, B L; Anhøj, Jacob; Bisgaard, A M;

    2004-01-01

    .i.d. delivered via Babyhaler, budesonide pressurized metered dose inhaler (pMDI) 200 microg b.i.d. delivered via Nebuchamber and placebo. Spacers were primed before use. In total, 40 children aged 1-3 years, with mild intermittent asthma were included. Twenty-five of the children completed all three treatments....... At the end of each treatment period body impedance and skin ultrasonography were measured. METHODS AND PROCEDURES: We measured changes in water content of the soft tissues by two methods. Skin ultrasonography was used to detect small changes in dermal water content, and bioelectrical impedance was used...... to assess body water content and distribution. MAIN OUTCOMES AND RESULTS: We found an increase in skin density of the shin from fluticasone as measured by ultrasonography (p = 0.01). There was a tendency for a consistent elevation of impedance parameters from active treatments compared to placebo although...

  8. Body fluid volumes measurements by impedance: A review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods.

    Science.gov (United States)

    Jaffrin, Michel Y; Morel, Hélène

    2008-12-01

    This paper reviews various bioimpedance methods permitting to measure non-invasively, extracellular, intracellular and total body water (TBW) and compares BIA methods based on empirical equations of the wrist-ankle resistance or impedance at 50 kHz, height and weight with BIS methods which rely on an electrical model of tissues and resistances measured at zero and infinite frequencies. In order to compare these methods, impedance measurements were made with a multifrequency Xitron 4200 impedance meter on 57 healthy subjects which had undergone simultaneously a Dual X-ray absorptiometry examination (DXA), in order to estimate their TBW from their fat-free-mass. Extracellular (ECW) and TBW volumes were calculated for these subjects using the original BIS method and modifications of Matthie[Matthie JR. Second generation mixture theory equation for estimating intracellular water using bioimpedance spectroscopy. J Appl Physiol 2005;99:780-1], Jaffrin et al. [Jaffrin MY, Fenech M, Moreno MV, Kieffer R. Total body water measurement by a modification of the bioimpédance spectroscopy method. Med Bio Eng Comput 2006;44:873-82], Moissl et al. [Moissl UM, Wabel P, Chamney PW, Bosaeus I, Levin NW, et al. Body fluid volume determination via body composition spectroscopy in health and disease. Physiol Meas 2006;27:921-33] and their TBW resistivities were compared and discussed. ECW volumes were calculated by BIA methods of Sergi et al. [Sergi G, Bussolotto M, Perini P, Calliari I, et al. Accuracy of bioelectrical bioimpedance analysis for the assessment of extracellular space in healthy subjects and in fluid retention states. Ann Nutr Metab 1994;38(3):158-65] and Hannan et al. [Hannan WJ, Cowen SJ, Fearon KC, Plester CE, Falconer JS, Richardson RA. Evaluation of multi-frequency bio-impedance analysis for the assessment of extracellular and total body water in surgical patients. Clin Sci 1994;86:479-85] and TBW volumes by BIA methods of Kushner and Schoeller [Kushner RF

  9. Percentile curves for body fatness and cut-offs to define malnutrition in Russians

    Science.gov (United States)

    Nikolaev, D. V.; Rudnev, S. G.; Starunova, O. A.; Eryukova, T. A.; Kolesnikov, V. A.; Ponomareva, E. G.; Soboleva, N. P.; Sterlikov, S. A.

    2013-04-01

    Here, we report first results of the large-scale ongoing bioelectrical impedance body composition study in Russians. By the end of 2012, 216 out of 800 Russian Health Centres submitted raw bioimpedance data on 844,221 adults and children aged 5-80 years, representing nearly 0.6% of the Russian population, who were accessed cross-sectionally using the same type of bioimpedance meter, ABC-01 Medas. Estimates of overweight, obesity, and normal weight obesity prevalence in the general population, as well as characteristics of diagnostic sensitivity and specificity of the conventional WHO BMI-based criteria of obesity depending on age are obtained. The smoothed reference centile curves for percentage fat mass are constructed, and localized cut-offs for fatness and thinness are provided that can be used both at the individual and epidemiological levels.

  10. Design of efficient and safe neural stimulators a multidisciplinary approach

    CERN Document Server

    van Dongen, Marijn

    2016-01-01

    This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson’s, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples. Provides a single-source, multidisciplinary reference to the field of neural stimulation, bridging an important knowledge gap among the fields of bioelectricity, neuroscience, neuroengineering and microelectronics;Uses a top-down approach to understanding the neural activation proc...

  11. Using of the interictal EEGs for epilepsy diagnosing

    Science.gov (United States)

    Panischev, O. Yu; Demin, S. A.; Zinatullin, E. M.

    2015-12-01

    In this work we apply a new method to determine the differences in characteristics of the cortical electroencephalographic (EEG) activity, measured during interictal stage (i.e., period between seizures), between healthy subjects and patients with epilepsy. To analyze the dynamical and spectral properties of bioelectric activity we use power spectra and phase portraits which are introduced on the basis of the Memory Function Formalism (MFF). We discover the significant differences in the types of power spectra of the EEG for healthy subjects and patients. We reveal the cerebral cortex areas for which the EEG activity of considered groups of subjects has a different structure of the phase portraits. The proposed approach can be used as an additional method for diagnosis of epilepsy during interictal stage.

  12. See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort?

    Science.gov (United States)

    Boyle, Patrick M; Entcheva, Emilia; Trayanova, Natalia A

    2014-01-01

    Cardiac optogenetics is an exciting new methodology in which light-sensitive ion channels are expressed in heart tissue to enable optical control of bioelectricity. This technology has the potential to open new avenues for safely and effectively treating rhythm disorders in the heart with gentle beams of light. Recently, we developed a comprehensive framework for modeling cardiac optogenetics. Simulations conducted in this platform will provide insights to guide in vitro investigation and steer the development of therapeutic applications - these are the first steps toward clinical translation. In this editorial, we review literature relevant to light-sensitive protein delivery and intracardiac illumination to provide a holistic feasibility assessment for optogenetics-based arrhythmia termination therapy. We then draw on examples from computational work to show that the optical control paradigm has undeniable advantages that cannot be attained with conventional electrotherapy. Hence, we argue that cardiac optogenetics is more than a flashy substitute for current approaches.

  13. EMG parameters and EEG α Index change at fatigue period during different types of muscle contraction

    Science.gov (United States)

    Zhang, Li; Zhou, Bin; Song, Gaoqing

    2011-03-01

    The purpose of this study is to measure and analyze the characteristics in change of EMG and EEG parameters at muscle fatigue period in participants with different exercise capacity. Twenty participants took part in the tests. They were divided into two groups, Group A (constant exerciser) and Group B (seldom-exerciser). MVC dynamic and 1/3 isometric exercises were performed; EMG and EEG signals were recorded synchronously during different type of muscle contraction. Results indicated that values of MVC, RMS and IEMG in Group A were greater than Group B, but isometric exercise time was shorter than the time of dynamic exercise although its intensity was light. Turning point of IEMG and α Index occurred synchronously during constant muscle contraction of isometric or dynamic exercise. It is concluded that IEMG turning point may be an indication to justify muscle fatigue. Synchronization of EEG and EMG reflects its common characteristics on its bio-electric change.

  14. Associations between Ultrasound Measures of Abdominal Fat Distribution and Indices of Glucose Metabolism in a Population at High Risk of Type 2 Diabetes: The ADDITION-PRO Study

    DEFF Research Database (Denmark)

    Philipsen, Annelotte; Jørgensen, Marit E; Vistisen, Dorte

    2015-01-01

    metabolism in a population at high risk of type 2 diabetes. METHODS: A cross-sectional analysis of 1342 participants of the ADDITION-PRO study. We measured visceral adipose tissue and subcutaneous adipose tissue with ultrasonography, anthropometrics and body fat percentage by bioelectrical impedance. Indices...... standard deviation difference in BMI, visceral adipose tissue, waist circumference, waist/height ratio and body fat percentage corresponded approximately to 0.2mmol/l higher fasting glucose, 0.7mmol/l higher 2-hr glucose, 0.06-0.1% higher HbA1c, 30 % lower HOMA index of insulin sensitivity, 20% lower Gutt......AIMS: Visceral adipose tissue measured by CT or MRI is strongly associated with an adverse metabolic risk profile. We assessed whether similar associations can be found with ultrasonography, by quantifying the strength of the relationship between different measures of obesity and indices of glucose...

  15. Body fat and fat-free mass and all-cause mortality

    DEFF Research Database (Denmark)

    Bigaard, Janne; Frederiksen, Kirsten; Tjønneland, Anne

    2004-01-01

    OBJECTIVE: To investigate whether the association between BMI and all-cause mortality could be disentangled into opposite effects of body fat and fat-free mass (FFM). RESEARCH METHODS AND PROCEDURES: All-cause mortality was studied in the Danish follow-up study "Diet, Cancer and Health" with 27......,178 men and 29,875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow-up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body...... fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits. RESULTS: Men and women showed similar associations. J-shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking...

  16. Bioelectronic DNA detection of human papillomaviruses using eSensor™: a model system for detection of multiple pathogens

    Directory of Open Access Journals (Sweden)

    Miller Donna L

    2003-06-01

    Full Text Available Abstract Background We used human papillomaviruses (HPV as a model system to evaluate the utility of a nucleic acid, hybridization-based bioelectronic DNA detection platform (eSensor™ in identifying multiple pathogens. Methods Two chips were spotted with capture probes consisting of DNA oligonucleotide sequences specific for HPV types. Electrically conductive signal probes were synthesized to be complementary to a distinct region of the amplified HPV target DNA. A portion of the HPV L1 region that was amplified by using consensus primers served as target DNA. The amplified target was mixed with a cocktail of signal probes and added to a cartridge containing a DNA chip to allow for hybridization with complementary capture probes. Results Two bioelectric chips were designed and successfully detected 86% of the HPV types contained in clinical samples. Conclusions This model system demonstrates the potential of the eSensor platform for rapid and integrated detection of multiple pathogens.

  17. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Prescott, Eva; Almdal, Thomas Peter

    2006-01-01

    Rationale: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population the harmful effect of low BMI is due to the deleterious effects of a low fat free mass index (FFMI, fat free mass/weight(2)). Objectives: We explored...... distribution of low FFMI and its association with prognosis in a population based cohort of COPD patients. Methods: We used data on 1,898 COPD patients identified in a population-based epidemiological study in Copenhagen. Fat free mass was measured using bioelectrical impedance analysis. Patients were followed...... the lowest FFMI 10(th) percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest FFMI 10(th) percentile of the general population was associated with a hazard ratio of 1.5 (95% confidence interval 1.2-1.8) for overall...

  18. Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

    Directory of Open Access Journals (Sweden)

    Renu Tyagi

    2015-03-01

    Full Text Available In the present study, the contribution of various biological and lifestyle factors toward progression to hypertension are examined among menopausal and postmenopausal women. A cross-sectional study among 245 women of 20 to 65 years was conducted. Besides blood pressure, fat percentage using bio-electric impedance analyzer and adiposity indices such as body mass index (BMI, waist–hip ratio (WHR, and waist–height ratio (WHtR were taken. Mean, standard deviation, ANOVA, and multinomial logistic were used to analyze the data. Statistically significant differences (p< .001 for blood pressure among postmenopausal and premenopausal women were found. Among both premenopausal and postmenopausal women, the prehypertensive and hypertensive group showed significant differences with the normotensive women for body weight (p< .005, regional obesity, and general obesity. Low educational level, working status of women, socioeconomic status, nuclear family setup, postmenopausal status, and obesity were found to be the likely risk factors for prehypertension or hypertension among women.

  19. Electrophysiological effects of dopamine receptor stimulation in the hippocampus of Acomys cahirinus.

    Science.gov (United States)

    Bijak, M; Danek, L; Smiałowski, A

    1988-01-01

    The effect of dopamine receptor agonists on the spontaneous bioelectrical activity of CA1 layer neurons in the hippocampal slice preparation from the Acomys and rat has been studied. The selective D1 receptor agonist SKF 38393 diminished the neuronal firing rate while the selective D2 receptor agonist LY 171555 (quinpirole) evoked an excitatory reaction, however, a great proportion of hippocampal neurons remained unresponsive to SKF 38393 and LY 171555. Both dopamine and apomorphine elicited mainly an increase in the neuronal discharge rate, the effect of the former having been antagonized by sulpiride. The present data reveal that the action of dopamine agonists on the hippocampal neurons of the Acomys generally resembles their activity on the rat hippocampal cells, however, the potency of dopamine and apomorphine in evoking the excitatory reaction is higher in the Acomys.

  20. Bioelectrochemical systems-driven directional ion transport enables low-energy water desalination, pollutant removal, and resource recovery.

    Science.gov (United States)

    Chen, Xi; Liang, Peng; Zhang, Xiaoyuan; Huang, Xia

    2016-09-01

    Bioelectrochemical systems (BESs) are integrated water treatment technologies that generate electricity using organic matter in wastewater. In situ use of bioelectricity can direct the migration of ionic substances in a BES, thereby enabling water desalination, resource recovery, and valuable substance production. Recently, much attention has been placed on the microbial desalination cells in BESs to drive water desalination, and various configurations have optimized electricity generation and desalination performance and also coupled hydrogen production, heavy metal reduction, and other reactions. In addition, directional transport of other types of charged ions can remediate polluted groundwater, recover nutrient, and produce valuable substances. To better promote the practical application, the use of BESs as directional drivers of ionic substances requires further optimization to improve energy use efficiency and treatment efficacy. This article reviews existing researches on BES-driven directional ion transport to treat wastewater and identifies a few key factors involved in efficiency optimization.

  1. Obesity and the obesity paradox in heart failure.

    Science.gov (United States)

    Gupta, Pritha P; Fonarow, Gregg C; Horwich, Tamara B

    2015-02-01

    Obesity has reached epidemic proportions in the general population and is associated with an increased risk for the development of new-onset heart failure (HF). However, in acute and chronic HF, overweight and mild to moderate obesity is associated with substantially improved survival compared with normal weight. This phenomenon has been termed the "obesity paradox" in HF. The majority of data pertaining to the obesity paradox identifies obesity with body mass index; however, the reliability of this method has been questioned. Newer studies have explored the use of other measures of body fat and body composition, including waist circumference, waist-to-hip ratio, skinfold thickness, and bioelectrical impedance analysis of body composition. The relationship between the obesity paradox and cardiorespiratory fitness in HF is also discussed in this review, and we explore the various potential explanations for the obesity paradox and summarize the current evidence and guidelines for intentional weight loss treatments for HF in the obese population.

  2. Neural signal registration and analysis of axons grown in microchannels

    Science.gov (United States)

    Pigareva, Y.; Malishev, E.; Gladkov, A.; Kolpakov, V.; Bukatin, A.; Mukhina, I.; Kazantsev, V.; Pimashkin, A.

    2016-08-01

    Registration of neuronal bioelectrical signals remains one of the main physical tools to study fundamental mechanisms of signal processing in the brain. Neurons generate spiking patterns which propagate through complex map of neural network connectivity. Extracellular recording of isolated axons grown in microchannels provides amplification of the signal for detailed study of spike propagation. In this study we used neuronal hippocampal cultures grown in microfluidic devices combined with microelectrode arrays to investigate a changes of electrical activity during neural network development. We found that after 5 days in vitro after culture plating the spiking activity appears first in microchannels and on the next 2-3 days appears on the electrodes of overall neural network. We conclude that such approach provides a convenient method to study neural signal processing and functional structure development on a single cell and network level of the neuronal culture.

  3. The N2-P3 complex of the evoked potential and human performance

    Science.gov (United States)

    Odonnell, Brian F.; Cohen, Ronald A.

    1988-01-01

    The N2-P3 complex and other endogenous components of human evoked potential provide a set of tools for the investigation of human perceptual and cognitive processes. These multidimensional measures of central nervous system bioelectrical activity respond to a variety of environmental and internal factors which have been experimentally characterized. Their application to the analysis of human performance in naturalistic task environments is just beginning. Converging evidence suggests that the N2-P3 complex reflects processes of stimulus evaluation, perceptual resource allocation, and decision making that proceed in parallel, rather than in series, with response generation. Utilization of these EP components may provide insights into the central nervous system mechanisms modulating task performance unavailable from behavioral measures alone. The sensitivity of the N2-P3 complex to neuropathology, psychopathology, and pharmacological manipulation suggests that these components might provide sensitive markers for the effects of environmental stressors on the human central nervous system.

  4. Application of acoustic-electric interaction for neuro-muscular activity mapping: A review

    Directory of Open Access Journals (Sweden)

    Thordur Helgason

    2014-11-01

    Full Text Available Acousto-electric interaction signal (AEI signal resulting from interaction of acoustic pressure wave and electrical current field has received recent attention in biomedical field for detection and registration of bioelectrical current. The signal is very of small value and brings about several challenges when detecting it. Several observations has been done in saline solution and on nerves and tissues under controlled condition that give optimistic indication about its utilization. Ultrasound Current Source Density Imaging (UCSDI has been introduced, that uses the AEI signal to image the current distribution. This review provides an overview of the investigations on the AEI signal and USCDI imaging that has been made, their results and several considerations on the limitations and future possibilities on using the acousto-electric interaction signal.

  5. Seven-channel digital telemetry system for monitoring and direct computer capturing of biological data.

    Science.gov (United States)

    Drewes, A M; Andreasen, A; Assentoft, J E; Nagel, O

    1993-09-01

    A seven-channel telemetry system for collection and display of biological data is presented. The system can amplify bioelectrical signals in the range of 2 microV to 200 mV and has a bandwidth of 0.1-80 Hz. After multiplexing, the signals are digitized with a resolution of 8 bits. The data are frequency modulated directly on a VHF transmitter. After receiving the data on a VHF receiver, they are routed directly to the RS232 input connector on the PC. Thereby the advantage of direct communication between the transmitter and the PC can be utilized. Expensive analog equipment is avoided and display of the signals on the PC screen as well as signal analysis can be performed. The system has been tested and was found to be stable and highly reliable.

  6. Controlling a virtual forehand prosthesis using an adaptive and affective Human-Machine Interface.

    Science.gov (United States)

    Rezazadeh, I Mohammad; Firoozabadi, S M P; Golpayegani, S M R Hashemi; Hu, H

    2011-01-01

    This paper presents the design of an adaptable Human-Machine Interface (HMI) for controlling virtual forearm prosthesis. Direct physical performance measures (obtained score and completion time) for the requested tasks were calculated. Furthermore, bioelectric signals from the forehead were recorded using one pair of electrodes placed on the frontal region of the subject head to extract the mental (affective) measures while performing the tasks. By employing the proposed algorithm and above measures, the proposed HMI can adapt itself to the subject's mental states, thus improving the usability of the interface. The quantitative results from 15 subjects show that the proposed HMI achieved better physical performance measures in comparison to a conventional non-adaptive myoelectric controller (p < 0.001).

  7. REMOVAL OF 50HZ POWERLINE INTERFERENCE FOR QUALITY DIAGNOSIS OF ECG SIGNAL

    Directory of Open Access Journals (Sweden)

    SIGMA BARICK

    2013-05-01

    Full Text Available The power line interference (50/60 Hz is the main source of noise in most of bio-electric signal. In this paper second order infinite impulse response (IIR notch filter, adaptive notch filtering technique with LMS (least mean square algorithm and Discrete Wavelet transform method has been proposed for the removal of power line interference from ECG signal. Different ECG signals from MIT/BIH arrhythmia database are used with added power-line interference noise which is common in ECG signal. The result is analyzed using MATLABsoftware. Basically two synthesis parameters MSE and SNR have been used. The prime aim of this paper is to adapt the discrete wavelet transform (DWT to improve the ECG signal quality for better clinical diagnosis. The proposed method shows improvement in output SNR is 97.60%.

  8. Does Inflammation Mediate the Obesity and BPH Relationship?

    DEFF Research Database (Denmark)

    Fowke, Jay H; Koyama, Tatsuki; Fadare, Oluwole;

    2016-01-01

    BACKGROUND: BPH is a common disease associated with age and obesity. However, the biological pathways between obesity and BPH are unknown. Our objective was to investigate biomarkers of systemic and prostate tissue inflammation as potential mediators of the obesity and BPH association. METHODS......: Participants included 191 men without prostate cancer at prostate biopsy. Trained staff measured weight, height, waist and hip circumferences, and body composition by bioelectric impedance analysis. Systemic inflammation was estimated by serum IL-6, IL-1β, IL-8, and TNF-α; and by urinary prostaglandin E2...... composition scales, systemic inflammation, and prostate tissue inflammation against BPH outcomes, including prostate size at ultrasound and LUTS severity by the AUA-symptom index (AUA-SI). RESULTS: Prostate size was significantly associated with all obesity measures. For example, prostate volume was 5.5 to 9...

  9. BMI or BIA: Is Body Mass Index or Body Fat Mass a Better Predictor of Cardiovascular Risk in Overweight or Obese Children and Adolescents?

    Directory of Open Access Journals (Sweden)

    Barbara Bohn

    2015-04-01

    Full Text Available Background: Body fat (BF percentiles for German children and adolescents have recently been published. This study aims to evaluate the association between bioelectrical impedance analysis(BIA-derived BF and cardiovascular risk factors and to investigate whether BF is better suited than BMI in children and adolescents. Methods: Data of 3,327 children and adolescents (BMI > 90th percentile were included. Spearman's correlation and receiver operating characteristics (ROCs were applied determining the associations between BMI or BF and cardiovascular risk factors (hypertension, dyslipidemia, elevated liver enzymes, abnormal carbohydrate metabolism. Area under the curve (AUC was calculated to predict cardiovascular risk factors. Results: A significant association between both obesity indices and hypertension was present (all p Conclusion: BIA-derived BF was not superior to BMI to predict cardiovascular risk factors in overweight or obese children and adolescents.

  10. Obesity and the obesity paradox in heart failure.

    Science.gov (United States)

    Clark, Adrienne L; Fonarow, Gregg C; Horwich, Tamara B

    2014-01-01

    Obesity is a growing public health problem in the general population, and significantly increases the risk for the development of new-onset heart failure (HF). However, in the setting of chronic HF, overweight and mild to moderate obesity is associated with substantially improved survival compared to normal-weight patients. Evidence exists for an "obesity paradox" in HF, with the majority of data measuring obesity by body mass index, but also across various less-frequently used measures of body fat (BF) and body composition including waist circumference, waist-hip ratio, skinfold estimates of percent BF, and bioelectrical impedance analysis of body composition. Other emerging areas of investigation such as the relationship of the obesity paradox to cardiorespiratory fitness are also discussed. Finally, this review explores various explanations for the obesity paradox, and summarizes the current evidence for intentional weight loss treatments for HF in context.

  11. Modeling of microfluidic microbial fuel cells using quantitative bacterial transport parameters

    Science.gov (United States)

    Mardanpour, Mohammad Mahdi; Yaghmaei, Soheila; Kalantar, Mohammad

    2017-02-01

    The objective of present study is to analyze the dynamic modeling of bioelectrochemical processes and improvement of the performance of previous models using quantitative data of bacterial transport parameters. The main deficiency of previous MFC models concerning spatial distribution of biocatalysts is an assumption of initial distribution of attached/suspended bacteria on electrode or in anolyte bulk which is the foundation for biofilm formation. In order to modify this imperfection, the quantification of chemotactic motility to understand the mechanisms of the suspended microorganisms' distribution in anolyte and/or their attachment to anode surface to extend the biofilm is implemented numerically. The spatial and temporal distributions of the bacteria, as well as the dynamic behavior of the anolyte and biofilm are simulated. The performance of the microfluidic MFC as a chemotaxis assay is assessed by analyzing the bacteria activity, substrate variation, bioelectricity production rate and the influences of external resistance on the biofilm and anolyte's features.

  12. Biological Fuel Cells and Membranes.

    Science.gov (United States)

    Ghassemi, Zahra; Slaughter, Gymama

    2017-01-17

    Biofuel cells have been widely used to generate bioelectricity. Early biofuel cells employ a semi-permeable membrane to separate the anodic and cathodic compartments. The impact of different membrane materials and compositions has also been explored. Some membrane materials are employed strictly as membrane separators, while some have gained significant attention in the immobilization of enzymes or microorganisms within or behind the membrane at the electrode surface. The membrane material affects the transfer rate of the chemical species (e.g., fuel, oxygen molecules, and products) involved in the chemical reaction, which in turn has an impact on the performance of the biofuel cell. For enzymatic biofuel cells, Nafion, modified Nafion, and chitosan membranes have been used widely and continue to hold great promise in the long-term stability of enzymes and microorganisms encapsulated within them. This article provides a review of the most widely used membrane materials in the development of enzymatic and microbial biofuel cells.

  13. Graft function and nutritional parameters in stable postrenal transplant patients.

    Science.gov (United States)

    Saxena, Anita; Sharma, R K; Gupta, Amit

    2016-03-01

    Bioelectrical impedance analysis (BIA) is a method for the assessment of nutritional status. We studied the effect of graft function on nutritional status in postrenal 45 transplant patients with borderline to good allograft function using BIA. The patients had a mean serum creatinine of 1.42 ± 0.42 mg% and mean glomerular filtration rate (GFR) of 45.1 ± 14.1 mL/min. Based on BIA-derived GFR, the patients were divided into two groups; group 1: borderline graft function GFR nutritional status compared with those in group 2. Based on phase angle, there were significant differences between group A (phase angle 4.0) in extracellular water (P nutritional status, but when compared with healthy individuals as assessed by BIA, there were significant differences in FM, FFM, and body cell mass. In conclusion, BIA was more sensitive to evaluate nutritional depletion than SGA in transplant patients with borderline.

  14. Optimized construction of biogas plants; Optimierte Bauweise fuer Biogasanlagen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-09-19

    Within the conference of the International Trade Fair for Biogas Plant Technology at 21st February, 2012 in Berlin, the following lectures were held: (1) Optimized dimensions of containers for small systems of liquid manure (Manfred Thalmann); (2) Microferm mini biogas plants (Bart Brouwer); (3) Fermentation of stackable biomass in rural biogas plant - The DeNaBa system (Christian Deterding); (4) The Sauter Biogas System for the fermentation of liquid manure, solid dung, and other residual materials (Stefan Sauter); (5) Bio-electricity: Controllable power generation by means of biogas plants (Matthias Sonnleitner); (6) Reduction of the effort and increase of the yield using UDR fixed bed technology (Alfred van den Berg); (7) Prestressed concrete container for biogas plants: Area of application - quality - options (Harald Feldmann); (8) Corrosion protection of agricultural and communal biogas plants (Michael Normann); (9) Fundamentals of efficient and effective flow generation in biogas plants (Kay Rotalski); (10) Rotary piston screw pistons and eccentric screw pumps (Thorsten Gilles).

  15. Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease.

    Science.gov (United States)

    Atmanli, Ayhan; Domian, Ibrahim John

    2016-12-19

    The advent of human pluripotent stem cell (hPSC) biology has opened unprecedented opportunities for the use of tissue engineering to generate human cardiac tissue for in vitro study. Engineering cardiac constructs that recapitulate human development and disease requires faithful recreation of the cardiac niche in vitro. Here we discuss recent progress in translating the in vivo cardiac microenvironment into PSC models of the human heart. We review three key physiologic features required to recreate the cardiac niche and facilitate normal cardiac differentiation and maturation: the biochemical, biophysical, and bioelectrical signaling cues. Finally, we discuss key barriers that must be overcome to fulfill the promise of stem cell biology in preclinical applications and ultimately in clinical practice.

  16. Transparent and Flexible Self-Charging Power Film and Its Application in a Sliding Unlock System in Touchpad Technology.

    Science.gov (United States)

    Luo, Jianjun; Tang, Wei; Fan, Feng Ru; Liu, Chaofeng; Pang, Yaokun; Cao, Guozhong; Wang, Zhong Lin

    2016-08-23

    Portable and wearable personal electronics and smart security systems are accelerating the development of transparent, flexible, and thin-film electronic devices. Here, we report a transparent and flexible self-charging power film (SCPF) that functions either as a power generator integrated with an energy storage unit or as a self-powered information input matrix. The SCPF possesses the capability of harvesting mechanical energy from finger motions, based on the coupling between the contact electrification and electrostatic induction effects, and meanwhile storing the generated energy. Under the fast finger sliding, the film can be charged from 0 to 2.5 V within 2094 s and discharge at 1 μA for approximately 1630 s. Furthermore, the film is able to identify personal characteristics during a sliding motion by recording the electric signals related to the person's individual bioelectricity, applied pressing force, sliding speed, and so on, which shows its potential applications in security systems in touchpad technology.

  17. Development of a Zigbee platform for bioinstrumentation.

    Science.gov (United States)

    Cifuentes, Carlos A; Gentiletti, Gabriel G; Suarez, Marco J; Rodriguez, Luis E

    2010-01-01

    This paper presents the development of a network platform which allows connecting multiple individual wireless devices for transmitting bioelectrics and biomechanics signals for application in a hospital network, or continuous monitoring in a patient's diary life. The Zigbee platform development proposal was made in three stages: 1) Hardware development, including the construction of a prototype network node and the integration of sensors, (2) Evaluation, in order to define the specifications of each node and scope of communication and (3) The Zigbee Network Implementation for bioinstrumentation based on ZigBee Health Care public application profile (ZHC). Finally, this work presents the experimental results based on measurements of Lost Packets and LQI (Link Quality Indicator), and the Zigbee Platform configuration for Bioinstrumentation in operation.

  18. Design and development of specific nanostructured systems based on biocompatible materials

    OpenAIRE

    Hassan López, Natalia

    2012-01-01

    Las diferentes aplicaciones y usos de las proteínas han crecido durante los últimos 50 años de forma continua. Sin embargo, en los últimos años hemos sido testigos de una irrefrenable aparición de aplicaciones más vanguardistas: materiales biomiméticos, ingeniería para tejidos, liberación de fármacos, bioelectrónica o modelos para nanopartículas. En este sentido, las interacciones entre moléculas pequeñas en solución de proteínas afectan su respectiva función bilógica y determina la estabilid...

  19. Development of a portable multi-channel system for plant physiological signal recording

    Directory of Open Access Journals (Sweden)

    Ting Li

    2016-06-01

    Full Text Available Bioelectrical signals can reflect physiological state of organs or tissues in plants and have a significant potential value in research of plant stress tolerance. In order to study the relationship between environment factors and electrical signals in plant, a portable multi-channel physiological signal acquisition system which relevant in plant physiology research was developed. Environment parameters and electrical signals can be measured in different channels by the acquisition system simultaneously and the measurement data will be displayed in an embedded integrated touch screen which is the system processing core. The system was validated to be stable and reliable after the calibration and repeated experiments of recording electrical signals in Helianthus annuus L.

  20. RELATIONSHIP OF CHARACTERISTICS OF MUSCULAR COORDINATION, BALANCE AND THE OF THE VEGETATIVE-VASCULAR DEPENDENTS ON DANCERS

    Directory of Open Access Journals (Sweden)

    Yu. P. Bredikhina

    2013-01-01

    Full Text Available Study the relation between the characteristics of muscle coordination, balance, and - vegetative-vascular balance on dancers. The dependence of balance and coordination abilities of the nature of the muscle and, in turn, from the vegetative-vascular support activities. The method of correlation analysis were confirmed by the relationship of coordination abilities with the characteristics of the bioelectrical activity of the muscles and vegetative-vascular support. All the above allows us to consider the formation of skills in ballroom dancing as a single functional system, in which the sense of balance and coordination abilities that determine the skill level of athletes associated with the information field of visual and vestibular reception, to the organization of the contractile activity of muscles and vegetative-vascular maintenance activities.

  1. Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium.

    Science.gov (United States)

    Ferrari, S; Kitson, C; Farley, R; Steel, R; Marriott, C; Parkins, D A; Scarpa, M; Wainwright, B; Evans, M J; Colledge, W H; Geddes, D M; Alton, E W

    2001-09-01

    Nonviral vectors have been shown to be a safe and valid alternative to recombinant viruses for gene therapy of cystic fibrosis (CF). Nevertheless, gene transfer efficiency needs to be increased before clinical efficacy is likely in man. One barrier to increased efficacy is normal airway mucus. Using an ex vivo model of sheep tracheal epithelium, we show that this barrier can, in part, be overcome by treatment with the mucolytic agents, Nacystelyn or N-acetylcysteine using either a cationic lipid or a cationic polymer as the gene transfer agent. Further, in vivo application of either Nacystelyn or the anticholinergic glycopyrrolate, both clinically used agents, resulted in increased reporter gene expression in the mouse lung, but no significant correction of the bioelectric defect in CF null mice. These results, whilst unlikely to be sufficient in themselves to achieve clinically relevant gene therapy, may be a further useful step in the attainment of this goal.

  2. Development of new muscle contraction sensor to replace sEMG for using in muscles analysis fields.

    Science.gov (United States)

    Zhang, D; Matsuoka, Y; Kong, W; Imtiaz, U; Bartolomeo, L; Cosentino, S; Zecca, M; Sessa, S; Ishii, H; Takanishi, A

    2014-01-01

    Nowadays, the technologies for detecting, processing and interpreting bioelectrical signals have improved tremendously. In particular, surface electromyography (sEMG) has gained momentum in a wide range of applications in various fields. However, sEMG sensing has several shortcomings, the most important being: measurements are heavily sensible to individual differences, sensors are difficult to position and very expensive. In this paper, the authors will present an innovative muscle contraction sensing device (MC sensor), aiming to replace sEMG sensing in the field of muscle movement analysis. Compared with sEMG, this sensor is easier to position, setup and use, less dependent from individual differences, and less expensive. Preliminary experiments, described in this paper, confirm that MC sensing is suitable for muscle contraction analysis, and compare the results of sEMG and MC sensor for the measurement of forearm muscle contraction.

  3. Comparison of methods for assessing nutritional status in HIV-infected adults.

    Science.gov (United States)

    Niyongabo, T; Melchior, J C; Henzel, D; Bouchaud, O; Larouzé, B

    1999-10-01

    Malnutrition is a frequent complication of human immunodeficiency virus (HIV) infection and is associated with a poor prognosis. To compare different measures of nutritional status in HIV-infected patients, we prospectively studied 88 outpatients seen at a Paris AIDS outpatient clinic for routine follow-up examinations. Nutritional status was assessed according to body weight loss (BWL, 4 classes), anthropometry, bioelectric impedance analysis (BIA), and subjective global assessment of nutritional status (SGA). Malnutrition was diagnosed in 22.4% of subjects using SGA, and 37.1% by BWL. SGA rapidly detected a worsening of nutritional status, while BWL detected malnutrition at an earlier stage. A good correlation was found between SGA class and body composition assessed by anthropometry and BIA. Deteriorating nutritional status diagnosed by SGA correlated with the CDC HIV disease class. SGA, a simple nutritional assessment, can serve as a basis for prescribing artificial nutrition, while BWL detects malnutrition at an earlier stage.

  4. [Dynamics of morphofunctional state of central nervous system in white rates exposed to vibration].

    Science.gov (United States)

    Pankov, V A; Katamanova, E V; Kuleshova, M V; Titov, E A; Kartapol'tseva, N V; Iakimova, N L; Lizarev, A V

    2014-01-01

    The authors presented results of experimental studies assessing influence of vibration on white rats. Dynamics of morphologic changes development in brain of experimental animals exposed to vibration were shown. Exposure to vibration in white rats daily during 4 hours over 15 days causes astrogliosis--compensation process in response to brain injury; over 1 month--causes morphologic brain changes (vacuoles formation in neuropile, decrease in astroglia cells number); over 2 months--causes lower plasticity of brain neurons, preserved astrogliosis; over 4 months--causes perivascular edema. Changes in brain bioelectric activity indicate stages of pathologic process in central nervous system. Increase in vibration exposure duration leads to more severe diffuse pathologic changes in brain and local cortical and diencephalic disorders. Exposure to vibration in white rats causes increase in general mobility, nonspecific activation of behaviour, intense emotional exertion, negative emotional state, but less severe effects of vibration were seen in orientative-trying reactions that are inborn, inherited forms of behaviour.

  5. Transformerless High-Quality Electrocardiogram and Body Impedance Recording by an Amplifier with Current-Driven Inputs

    Directory of Open Access Journals (Sweden)

    Dobrev D.

    2009-12-01

    Full Text Available Measurement and recording of changes in bioelectrical impedance in vivo has become a widely used method with various clinical applications. It includes basal impedance Zo, relative changes ΔZ or its derivative dZ. Many applications related to cardiac and respiratory function require simultaneous electrocardiogram, impedance cardiogram and/or respiration signals recording and analysis. Accurate recording of body impedance is limited by high common mode voltages at the amplifier inputs combined with the influence of the output impedance of the used current source. A circuit concept for a simultaneous high-quality electrocardiogram and bioimpedance acquisition is proposed, profiting from advantages offered by a previously specially designed amplifier with current-driven inputs, yielding to low common mode and high differential mode input impedances.

  6. Does bioimpedance analysis or measurement of natriuretic peptides aid volume assessment in peritoneal dialysis patients?

    Science.gov (United States)

    Davenport, Andrew

    2013-01-01

    Cardiovascular mortality remains the commonest cause of death for peritoneal dialysis patients. As such, preventing persistent hypervolemia is important. On the other hand, hypovolemia may potentially risk episodes of acute kidney injury and loss of residual renal function, a major determinant of peritoneal dialysis technique survival. Bioimpedance has developed from a single-frequency research tool to a multi-frequency bioelectrical impedance analysis readily available in the clinic and capable of measuring extracellular, intracellular, and total body water. Similarly, natriuretic peptides released from the heart because of myocardial stretch and increased intracardiac volume have also been variously reported to be helpful in assessing volume status in peritoneal dialysis patients. The question then arises whether these newer technologies and biomarkers have supplanted the time-honored clinical assessment of hydration status or whether they are merely adjuncts that aid the experienced clinician.

  7. Performance Evaluation of Zigbee Transceiver for Wireless Body Sensor System

    Directory of Open Access Journals (Sweden)

    Ruchita Pandey

    2014-06-01

    Full Text Available A cost effective impedance measurement system and a low costtransceiver device has been presented for wireless body sensor systems.The proposed device has an analog front end to measure bioimpedance and ZigBee device which provides reliable wireless communication.Bioelectric Impedance measurement enables to characterize the state of tissues.Tetrapolar method is an advance method for measuring impedance since it is a very easy and simple method for practical implementation.The principle of modified tetrapolar method and its wireless transimission through zigbee has been investigated here.Different modulation technique has been applied and it has been found that MSK based transceiver is an efficient one since it has low bit error rate and it produce constant envelope carrier signals which have no amplitude and phase varations,hence it will be a more power saving technique.

  8. Measurement of localized tissue water - clinical application of bioimpedance spectroscopy in wound management

    Science.gov (United States)

    Ward, L. C.; Sharpe, K.; Edgar, D.; Finlay, V.; Wood, F.

    2013-04-01

    Wound healing is a complex process which can be impeded by the presence of accumulated cell fluid or oedema. A simple and convenient method for the assessment of wound oedema would aid improvement in patient care. In this proof of concept study we investigated whether bioelectrical impedance spectroscopy has the potential to provide such a tool. A number of important observations were made. Firstly, the method was highly reproducible and data can be obtained from electrodes located at different positions around the region of interest; important given the highly variable topography of surface wounds, e.g. burns. Secondly, the method was highly sensitive with the potential to detect changes of as little as 20 μl in extracellular fluid. Thirdly the relative changes in R0, R∞ and Ri following sub-cutaneous injections of saline were consistent with redistribution of water from the extracellular to intracellular space and /or removal from the local area as may occur during wound healing.

  9. Novel monitoring method for the management of heart failure: combined measurement of body weight and bioimpedance index of body fat percentage.

    Science.gov (United States)

    Kataoka, Hajime

    2009-11-01

    Although body weight scales are most commonly used to evaluate body fluid status during follow-up of definite heart failure (HF) patients, bioimpedance measurement methods have become increasingly available in the clinical setting. These monitoring methods, however, are typically used separately to evaluate body fluid status in HF patients. Kataoka developed a novel method for monitoring HF patients using a digital weight scale that incorporated a bioelectrical impedance analyzer. This method combines the well-known advantages of body weighing with a refined bioimpedance technique to monitor HF status and provides valid information regarding a change in a patient's body fluid status during follow-up for HF, such as predominant fluid versus fat weight gain or loss. This special report describes examples of the practical use of this method for monitoring and treating definite HF patients.

  10. A Planar Interdigital Sensor for Bio-impedance Measurement: Theoretical analysis, Optimization and Simulation

    Directory of Open Access Journals (Sweden)

    Thanh-Tuan Ngo

    2014-04-01

    Full Text Available This paper proposes the design of a biosensor to characterize the dielectric and conductive properties of biological materials (for example blood or water by impedance spectroscopy. Particularly, its design optimized the geometric structure interdigitated electrodes. This optimization allows extending the frequency range of measurement by reducing the polarization effect. Polarization effect is manifested by an interface capability (or double layer from interaction between ions and molecules in the boundary between the surface of the electrolyte and the electrodes, it increases the measurement error at low frequencies. This paper recommends also a novel method to determine the parameters (relative permittivity, thickness and capacitance per unit area of the double layer (DL at the contact surface of the electrode with the solution. CoventorWare software was utilized to modelize of interdigital sensor structure in three dimensions (3D to verify the analytical results and evaluate the influence of geometrical parameters and the dielectric properties of the medium on bioelectrical impedance.

  11. Estimation of limb adiposity by bioimpedance spectroscopy in lymphoedema

    Science.gov (United States)

    Ward, L. C.; Essex, T.; Gaw, R.; Czerniec, S.; Dylke, E.; Abell, B.; Kilbreath, S. L.

    2013-04-01

    Lymphoedema is a chronic debilitating condition that may occur in approximately 25% of women treated for breast cancer. As the condition progresses, accumulated lymph fluid becomes fibrotic with infiltration of adipose tissue. Bioelectrical impedance spectroscopy is the preferred method for early detection of lymphoedema based on the measurement of impedance of extracellular fluid. The present study assessed whether these impedance measurements could also be used to estimate the adipose tissue content of the arm based on a model previously used to predict whole body composition. Estimates of arm adipose tissue in a cohort of women with lymphoedema were found to be highly correlated (r > 0.82) with measurements of adipose tissue obtained using the reference method of dual energy X-ray absorptiometry. Paired t-tests confirmed that there was no significant difference between the adipose tissue volumes obtained by the two methods. These results support the view that the method shows promise for the estimation of arm adiposity in lymphoedema.

  12. Determining conduction patterns on a sparse electrode grid: Implications for the analysis of clinical arrhythmias

    Science.gov (United States)

    Vidmar, David; Narayan, Sanjiv M.; Krummen, David E.; Rappel, Wouter-Jan

    2016-11-01

    We present a general method of utilizing bioelectric recordings from a spatially sparse electrode grid to compute a dynamic vector field describing the underlying propagation of electrical activity. This vector field, termed the wave-front flow field, permits quantitative analysis of the magnitude of rotational activity (vorticity) and focal activity (divergence) at each spatial point. We apply this method to signals recorded during arrhythmias in human atria and ventricles using a multipolar contact catheter and show that the flow fields correlate with corresponding activation maps. Further, regions of elevated vorticity and divergence correspond to sites identified as clinically significant rotors and focal sources where therapeutic intervention can be effective. These flow fields can provide quantitative insights into the dynamics of normal and abnormal conduction in humans and could potentially be used to enhance therapies for cardiac arrhythmias.

  13. Electronic Interfacing with Living Cells

    Science.gov (United States)

    Fleming, James T.

    The direct interfacing of living cells with inorganic electronic materials, components or systems has led to the development of two broad categories of devices that can (1) transduce biochemical signals generated by biological components into electrical signals and (2) transduce electronically generated signals into biochemical signals. The first category of devices permits the monitoring of living cells, the second, enables control of cellular processes. This review will survey this exciting area with emphasis on the fundamental issues and obstacles faced by researchers. Devices and applications that use both prokaryotic (microbial) and eukaryotic (mammalian) cells will be covered. Individual devices described include microbial biofuel cells that produce electricity, bioelectrical reactors that enable electronic control of cellular metabolism, living cell biosensors for the detection of chemicals and devices that permit monitoring and control of mammalian physiology.

  14. Performance analysis of adjustable window based FIR filter for noisy ECG Signal Filtering

    Directory of Open Access Journals (Sweden)

    N. Mahawar

    2013-09-01

    Full Text Available Recording of the electrical activity associated to heart functioning is known as Electrocardiogram (ECG. ECG is a quasi-periodical, rhythmically signal synchronized by the function of the heart, which acts as a generator of bioelectric events. ECG signals are low level signals and sensitive to external contaminations. Electrocardiogram signals are often corrupted by noise which may have electrical or electrophysiological origin. The noise signal tends to alter the signal morphology, thereby hindering the correct diagnosis. In order to remove the unwanted noise, a digital filtering technique based on adjustable windows is proposed in this paper. Finite Impulse Response (FIR low pass is designed using windowing method for the ECG signal. The results obtained from different techniques are compared on the basis of popularly used signal error measures like SNR, PRD, PRD1, and MSE.

  15. Noncontact ECG system for unobtrusive long-term monitoring.

    Science.gov (United States)

    McDonald, Neil J; Anumula, Harini A; Duff, Eric; Soussou, Walid

    2012-01-01

    This paper describes measurements made using an ECG system with QUASAR's capacitive bioelectrodes integrated into a pad system that is placed over a chair. QUASAR's capacitive bioelectrode has the property of measuring bioelectric potentials at a small separation from the body. This enables the measurement of ECG signals through fabric, without the removal of clothing or preparation of skin. The ECG was measured through the subject's clothing while the subject sat in the chair without any supporting action from the subject. The ECG pad system is an example of a high compliance system that places minimal requirements upon the subject and, consequently, can be used to generate a long-term record from ECG segments collected on a daily basis, providing valuable information on long-term trends in cardiac health.

  16. In vivo evaluation of an episcleral multielectrode array for stimulation of the retina with reduced retinal ganglion cell mass.

    Science.gov (United States)

    Siu, Timothy L; Morley, John W

    2008-05-01

    A visual prosthesis is an experimental device designed to activate residual functional neurons in the visual pathway to generate artificial vision for blind patients. Specifically, for photoreceptor disease, a microelectrode array applied to the surface of the sclera could potentially serve to stimulate the remaining interneurons in the retina to produce topographically mapped visual percepts. However, of those neurons spared in the disease process, the retinal ganglion cells (RGC), which represent the final output neurons of the retina, can be markedly reduced in number. Using an albino rabbit model with RGC deficits, acute recording of cortical electrical evoked potential was performed to ascertain whether such a stimulation strategy is feasible. By analyzing the strength-duration curve (current threshold vs. pulse duration) and cortical activation profiles, our results prove that bioelectrically safe and spatially differentiated stimulation of the retina is feasible notwithstanding the condition of markedly reduced RGC counts.

  17. [The study of sleep in full term and preterm neonates with EEG polygraphy].

    Science.gov (United States)

    Borsini, W; Lambruschini, P; Marcacci, G

    1990-01-01

    We accomplished polygraphies in two groups of infants: 1) preterm infants born before 33 weeks CA, and recorded between 33 and 48 weeks CA; 2) full term infants, recorded between 39 and 48 weeks CA. We compared in each group of infants: 1) the development of behavioral states organization; 2) the maturation of cortical bioelectric activities; 3) the development of concordance between behavioral states and EEG pattern; 4) sequences of behavioral states and EEG pattern when the babies fall asleep. In all the aspects considered, we describe some developmental changes, to understand how, through these changes, the newborn sleep-wake ultradian cycle is replaced by 24 hr-cycle, typical of the infantile period. This basic process is expression of maturation of the central nervous system because it is related to CA and not to extrauterine experience. The EEG-polygraph usually used in clinical practice allow us to follow these extraordinary transformations very closely.

  18. Synergistic effect of exogeneous and endogeneous electrostimulation on osteogenic differentiation of human mesenchymal stem cells seeded on silk scaffolds.

    Science.gov (United States)

    Çakmak, Anıl S; Çakmak, Soner; White, James D; Raja, Waseem K; Kim, Kyungsook; Yiğit, Sezin; Kaplan, David L; Gümüşderelioğlu, Menemşe

    2016-04-01

    Bioelectrical regulation of bone fracture healing is important for many cellular events such as proliferation, migration, and differentiation. The aim of this study was to investigate the osteogenic differentiation potential of human mesenchymal stem cells (hMSCs) cultivated on silk scaffolds in response to different modes of electrostimulation (e.g., exogeneous and/or endogeneous). Endogeneous electrophysiology was altered through the use of monensin (10 nM) and glibenclamide (10 μM), along with external electrostimulation (60 kHz; 100-500 mV). Monensin enhanced the expression of early osteogenic markers such as alkaline phosphatase (ALP) and runt-related transcription factor 2 (RUNX-2). When exogeneous electrostimulation was combined with glibenclamide, more mature osteogenic marker upregulation based on bone sialoprotein expression (BSP) and mineralization was found. These results suggest the potential to exploit both exogeneous and endogeneous biophysical control of cell functions towards tissue-specific goals.

  19. [Neurotoxic effect of toluene on background of prenatal hypoxic brain damage to white rats].

    Science.gov (United States)

    Vokina, V A; Sosedova, L M; Rukavishnikov, V S; Iakimova, N L; Lizarev, A V

    2014-01-01

    Comparative study covered influence of toluene on behavioral parameters, cognitive abilities and brain bioelectric activity in white rats with normal embryonic development or with prenatal hypoxia. Prenatal hypoxia was simulated by subcutaneous injection of 50 mg/kg sodium nitrite into female white rats on day 13-14 of gestation. The offspring at the age of 2, 5-3 months was exposed to toluene (concentration of 560 mg/m3, 4 hours per day, 5 days per week, over 4 weeks). After the exposure, the animals were estimated for individual and intraspecific behaviour in "open fields and "resident-intruder" tests, for cognitive abilities in "radial maze" training, EEG with visual and auditory evoked potentials. Acute hypoxia at early stages of organogenesis appeared to be burdening factor and to influence consequences of toluene intoxication.

  20. Magnetoencephalography in the study of epilepsy and consciousness.

    Science.gov (United States)

    Foley, Elaine; Cerquiglini, Antonella; Cavanna, Andrea; Nakubulwa, Mable Angela; Furlong, Paul Lawrence; Witton, Caroline; Seri, Stefano

    2014-01-01

    The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges.

  1. Comparison in maternal body composition between Caucasian Irish and Indian women.

    LENUS (Irish Health Repository)

    Farah, N

    2012-02-01

    The use of body mass index (BMI) for the diagnosis of obesity has limitations, especially when comparing ethnic groups with different body proportions. The aim of this prospective study was to compare maternal body composition in early pregnancy between Caucasian Irish and Indian women. A total of 81 Indian women and 81 Irish Caucasian women were matched for age, parity and BMI. Maternal weight and height were measured, and body composition analysed using bioelectrical impedance. The Irish women were taller and weighed more than the Indian women (p<0.001). At any given BMI, the Indian women had a higher total body fat percentage, visceral fat level and high fat percentage than the Irish women (p=0.024, 0.001 and 0.001, respectively). Our findings suggest that lower BMI cut-offs should be used for screening for gestational diabetes mellitus in Indian women attending our antenatal services.

  2. Comparison of ion transport by cultured secretory and absorptive canine airway epithelia

    DEFF Research Database (Denmark)

    Boucher, R C; Larsen, Erik Hviid

    1988-01-01

    The use of primary cell culture techniques to predict the function of native respiratory epithelia was tested in studies of dog airway epithelia. Epithelial cells from Cl- secretory (tracheal) and Na+ absorptive (bronchial) airway regions were isolated by enzymatic digestion, plated on collagen...... sensitive to amiloride but insensitive to bumetanide. As compared with the trachea, the bronchial (absorptive) epithelium is characterized by 1) a large amiloride-sensitive cellular conductance and 2) a relatively depolarized basolateral membrane. We conclude that this primary cell culture technique...... matrices, and maintained in serum-free, hormone-supplemented media. Transepithelial and intracellular studies showed that both the tracheal and bronchial culture preparations exhibited bioelectric parameters quantitatively similar to those of intact tissues. Similar to the native tissue, the tracheal...

  3. Modification effects of physical activity and protein intake on heritability of body size and composition

    DEFF Research Database (Denmark)

    Silventoinen, Karri; Hasselbalch, Ann Louise; Lallukka, Tea

    2009-01-01

    BACKGROUND: The development of obesity is still a poorly understood process that is dependent on both genetic and environmental factors. OBJECTIVE: The objective was to examine how physical activity and the proportion of energy as protein in the diet modify the genetic variation of body mass index....... The participants reported the frequency and intensity of their leisure time physical activity. Waist circumference and BMI were measured. Percentage body fat was assessed in Denmark by using a bioelectrical impedance method. The data were analyzed by using gene-environment interaction models for twin data...... with the Mx statistical package (Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA). RESULTS: High physical activity was associated with lower mean values, and a high proportion of protein in the diet was associated with higher mean BMI, waist...

  4. COPD, Body Mass, Fat Free Body Mass and prognosis in Patients from a Random Population Sample

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Prescott, E; Almdal, Thomas Peter;

    2006-01-01

    RATIONALE: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population, the harmful effect of low BMI is due to the deleterious effects of a low fat-free mass index (FFMI; fat-free mass/weight(2)). OBJECTIVES: We explored...... distribution of low FFMI and its association with prognosis in a population-based cohort of patients with COPD. METHODS: We used data on 1,898 patients with COPD identified in a population-based epidemiologic study in Copenhagen. FFM was measured using bioelectrical impedance analysis. Patients were followed...... 10th percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest 10th percentile of the general population for FFMI was associated with a hazard ratio of 1.5 (95% confidence interval, 1.2-1.8) for overall...

  5. Biomaterials-based electronics: polymers and interfaces for biology and medicine.

    Science.gov (United States)

    Muskovich, Meredith; Bettinger, Christopher J

    2012-05-01

    Advanced polymeric biomaterials continue to serve as a cornerstone for new medical technologies and therapies. The vast majority of these materials, both natural and synthetic, interact with biological matter in the absence of direct electronic communication. However, biological systems have evolved to synthesize and utilize naturally-derived materials for the generation and modulation of electrical potentials, voltage gradients, and ion flows. Bioelectric phenomena can be translated into potent signaling cues for intra- and inter-cellular communication. These cues can serve as a gateway to link synthetic devices with biological systems. This progress report will provide an update on advances in the application of electronically active biomaterials for use in organic electronics and bio-interfaces. Specific focus will be granted to covering technologies where natural and synthetic biological materials serve as integral components such as thin film electronics, in vitro cell culture models, and implantable medical devices. Future perspectives and emerging challenges will also be highlighted.

  6. Resistivity and phase in localized BIA

    Science.gov (United States)

    Shiffman, C. A.; Aaron, R.; Amoss, V.; Therrien, J.; Coomler, K.

    1999-10-01

    We describe a system for highly reproducible non-invasive rf impedance measurements as a function of position along body segments such as the thigh. Results are reported for mainly healthy male and female subjects ranging in age from 19 to 65 and in body-mass index from 15 to 40. A principal conclusion is that the phase of the impedance falls monotonically with increasing distance from the knee, with average values substantially above what is found using standard, whole-body bioelectrical impedance analysis (BIA). To compensate for thigh shape, the data are further analysed using an anatomical model based on reasonable approximations for the distributions of muscle, fat and bone, yielding values of the effective resistivity for current flow parallel to the muscle fibres. The phase and resistivity results are discussed with reference to the whole-body BIA study of maintenance haemodialysis patients by Chertow et al, and in regard to possible physiological correlations observed in this work.

  7. Mathematical cardiac electrophysiology

    CERN Document Server

    Colli Franzone, Piero; Scacchi, Simone

    2014-01-01

    This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematica...

  8. Electrical dimensions in cell science.

    Science.gov (United States)

    McCaig, Colin D; Song, Bing; Rajnicek, Ann M

    2009-12-01

    Cells undergo a variety of physiological processes, including division, migration and differentiation, under the influence of endogenous electrical cues, which are generated physiologically and pathologically in the extracellular and sometimes intracellular spaces. These signals are transduced to regulate cell behaviours profoundly, both in vitro and in vivo. Bioelectricity influences cellular processes as fundamental as control of the cell cycle, cell proliferation, cancer-cell migration, electrical signalling in the adult brain, embryonic neuronal cell migration, axon outgrowth, spinal-cord repair, epithelial wound repair, tissue regeneration and establishment of left-right body asymmetry. In addition to direct effects on cells, electrical gradients interact with coexisting extracellular chemical gradients. Indeed, cells can integrate and respond to electrical and chemical cues in combination. This Commentary details how electrical signals control multiple cell behaviours and argues that study of the interplay between combined electrical and chemical gradients is underdeveloped yet necessary.

  9. Use of low-frequency electrical impedance measurements to determine phospholipid content in amniotic fluid

    Science.gov (United States)

    DeLuca, F.; Cametti, C.; Zimatore, G.; Maraviglia, B.; Pachi', A.

    1996-09-01

    In this report we propose a new method for an in vitro test of the foetal lung maturity based on the measurement of the electrical conductivity of the overall amniotic fluid obtained from transabdominal amniocentesis, since this quantity can be linked to a first approximation in a very simple way to the phospholipid content. We have carried out measurements of 85 different samples of amniotic fluid as a function of gestation weeks and we have observed a pronounced change of the electrical conductivity that reflects the increase in the phospholipid concentration occurring at the end of normal pregnancies. The method could be further developed to obtain similar information on in vivo experiments by means of bioelectric impedance tomography, taking advantage of the frequency dependence of the tissue electrical impedance.

  10. Height Growth and Percentage of Body Fat in Relation to Early Menarche in Girls from Merida, Yucatan, Mexico.

    Science.gov (United States)

    Datta Banik, Sudip; Mendez, Nina; Dickinson, Federico

    2015-01-01

    Early menarche (EM) (i.e., age at menarche [AAM] Yucatan, height, body mass index (BMI), and percentage of body fat (BF%) were recorded at a one-year interval among 258 postmenarcheal (EM = 94) girls. Anthropometric measurements were recorded of the age cohorts in 2008-09 when participants were 13-17 years of age (baseline), and in the one-year follow-up study (± 6 days) the girls were 14-18 years of age. The BF% was estimated through bioelectrical impedance analysis. Mean AAM was 10.59 years in EM girls and 12.54 years in not early menarche (NEM) girls. Height growth (cm/year) was greater in NEM girls. Mean values of BMI, BF%, and frequencies of stunting (low height-for-age) and excess weight (overweight + obesity) were higher in EM girls than in their NEM age peers.

  11. Pattern Recognition of EEG Signals and Applications in Robotics

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-dong; CHENG Zhi-qiang; LI De-jun

    2006-01-01

    With the rapid development of brain computer interface (simply called BCI),electroencephalography (EEG) will be another interesting bio-electrical signal applied in robotics after EMG.In order to realize it finally,the accurate measurement and pattern recognition of EEG signal must be a very important and elementary research objective.Based on our current researches and some reports from the other international colleagues in the field,we deeply discuss the basic characteristics of EEG signal,the development and selection of EEG measurement system,feature extraction and recognition methods of EEG signal,and then review EEG's applications in robotics as well as the future research trends in this paper.

  12. Influence of bee pollen on the central nervous system of animals

    Directory of Open Access Journals (Sweden)

    O. V. Severynovs’ka

    2007-02-01

    Full Text Available Influence of bee pollen on the state of the central nervous system of white laboratory rats is studied. The behavioural reactions were estimated in „an opened field”. The bioelectric activity recording was conducted on frontoparietal cortex, dorsal hippocampus and hypothalamus with the standard electro-physiology equipment. It is shown that bee pollen results in the increase of absolute indices of constituents of brain electric activity, in the reduction of the part of slow low-frequency and in the increase of power of fast high-frequency components. It becomes apparent as a rise in the spontaneous motive activity and development of orientative-trying strategy of behaviour, which specifies on favourable influence of this preparation on CNS.

  13. Musical expertise affects neural bases of letter recognition.

    Science.gov (United States)

    Proverbio, Alice Mado; Manfredi, Mirella; Zani, Alberto; Adorni, Roberta

    2013-02-01

    It is known that early music learning (playing of an instrument) modifies functional brain structure (both white and gray matter) and connectivity, especially callosal transfer, motor control/coordination and auditory processing. We compared visual processing of notes and words in 15 professional musicians and 15 controls by recording their synchronized bioelectrical activity (ERPs) in response to words and notes. We found that musical training in childhood (from age ~8 years) modifies neural mechanisms of word reading, whatever the genetic predisposition, which was unknown. While letter processing was strongly left-lateralized in controls, the fusiform (BA37) and inferior occipital gyri (BA18) were activated in both hemispheres in musicians for both word and music processing. The evidence that the neural mechanism of letter processing differed in musicians and controls (being absolutely bilateral in musicians) suggests that musical expertise modifies the neural mechanisms of letter reading.

  14. Canceling Interference in Acupuncture Points Signal

    Directory of Open Access Journals (Sweden)

    Yanexy San Martín Reyes

    2012-07-01

    Full Text Available The present paper propose the cancellation of interference or artifacts by the method of Allen in signals captured in different acupuncture points (Small Intestine Meridian, points ID1-ID2 and ID1-ID19. It is considered that the biosignal under study should be able to be characterized after its acquisition by subtracting the different interference variables that may coexist in the measurement zone, as it is in the case of ECG or any other artifact. The biosignal obtained as a result of the cancellation will be the acupuncture signal or from its imperfection another wave can be obtained as from a bioelectrical point of view such imperfection can be characterized and at the same time can bb useful to establish a long-term correspondence between the behavior of the signals on various acupuncture points and different diseases.

  15. Behaviour of the electrical impedance myography in isometric contraction of biceps brachii at different elbow joint angles

    Science.gov (United States)

    Coutinho, A. B. B.; Jotta, B.; Pino, A. V.; Souza, M. N.

    2012-12-01

    Electrical impedance myography (EIM) can be understood as an experimental technique applied to evaluate bioelectrical impedance associated to the muscular activity. With the development of technique, some studies are trying to associate the EIM parameters with the morphological and physiological changes that occur in the muscle during contraction. In this context this work sought to associate EIM parameters observed during isometric contractions of the biceps brachii muscle at different elbow joint angles with the correspondent muscular force. Differently from previous works that did not observe significant correlation between those data, our findings point to high correlations between the some EIM resistive parameters and the muscle force. Despite the need of further investigation, our results indicated that EIM technique can be used to estimate muscle force in a noninvasive way.

  16. Dynamics of the component of body composition in athletes playing sports with damage to the medial meniscus of the knee

    Directory of Open Access Journals (Sweden)

    Moh'd Khalil Moh'd Abdel Kader

    2012-11-01

    Full Text Available The question of the influence of the developed program of physical rehabilitation with the use of modern means and methods of recovery on the performance component of body composition in athletes playing sports after arthroscopic stapling the medial meniscus was considered. The analysis and synthesis of scientific and methodological data on the determination of body composition analysis techniques using bioelectrical resistance was shown. Found that long-term immobilization that accompanies the process of rehabilitation, reduced physical activity, vascular and other changes lead to muscle atrophy, restriction of mobility in the knee joint, trophic changes of the injured limb. The use of the physical rehabilitation programs allowed to state its high efficiency.

  17. Enhancement of bacterial denitrification for nitrate removal in groundwater with electrical stimulation from microbial fuel cells

    Science.gov (United States)

    Zhang, Baogang; Liu, Ye; Tong, Shuang; Zheng, Maosheng; Zhao, Yinxin; Tian, Caixing; Liu, Hengyuan; Feng, Chuanping

    2014-12-01

    Electricity generated from the microbial fuel cell (MFC) is applied to the bioelectrical reactor (BER) directly as electrical stimulation means for enhancement of bacterial denitrification to remove nitrate effectively from groundwater. With maximum power density of 502.5 mW m-2 and voltage outputs ranging from 500 mV to 700 mV, the nitrate removal is accelerated, with less intermediates accumulation, compared with control sets without electrical stimulation. Denitrification bacteria proliferations and activities are promoted as its number and Adenosine-5'-triphosphate (ATP) concentration increased one order of magnitude (3.5 × 107 in per milliliter biofilm solution) and about 1.5 folds, respectively. Effects of electricity from MFCs on enhancement of bacterial behaviors are demonstrated for the first time. These results indicate that MFCs can be applied in the in-situ bioremediation of nitrate polluted groundwater for efficiency improvement.

  18. Non-polarisable dry electrode based on NASICON ceramic.

    Science.gov (United States)

    Gondran, C; Siebert, E; Fabry, P; Novakov, E; Gumery, P Y

    1995-05-01

    A NASICON-type ceramic (high sodium ion conductor) is proposed to record bioelectric signals. The electrode does not need gel before its application. The principle of the measurements is based on a sodium ion exchange between the skin and the material. Electrical measurements performed in saline solutions show that the electrode is slightly polarisable. The skin-electrode impedance was investigated. The impedance decreases as a function of the time of application. The resistive component is the major source of the impedance change. This can be explained by the perspiration process which occurs immediately with time after the application of the NASICON-based electrode on the skin. The skin condition is also an important parameter. NaCl saline solution or abrasion causes the resistance to decrease markedly.

  19. Accuracy of Specific BIVA for the Assessment of Body Composition in the United States Population

    Science.gov (United States)

    Buffa, Roberto; Saragat, Bruno; Cabras, Stefano; Rinaldi, Andrea C.; Marini, Elisabetta

    2013-01-01

    Background Bioelectrical impedance vector analysis (BIVA) is a technique for the assessment of hydration and nutritional status, used in the clinical practice. Specific BIVA is an analytical variant, recently proposed for the Italian elderly population, that adjusts bioelectrical values for body geometry. Objective Evaluating the accuracy of specific BIVA in the adult U.S. population, compared to the ‘classic’ BIVA procedure, using DXA as the reference technique, in order to obtain an interpretative model of body composition. Design A cross-sectional sample of 1590 adult individuals (836 men and 754 women, 21–49 years old) derived from the NHANES 2003–2004 was considered. Classic and specific BIVA were applied. The sensitivity and specificity in recognizing individuals below the 5th and above the 95th percentiles of percent fat (FMDXA%) and extracellular/intracellular water (ECW/ICW) ratio were evaluated by receiver operating characteristic (ROC) curves. Classic and specific BIVA results were compared by a probit multiple-regression. Results Specific BIVA was significantly more accurate than classic BIVA in evaluating FMDXA% (ROC areas: 0.84–0.92 and 0.49–0.61 respectively; p = 0.002). The evaluation of ECW/ICW was accurate (ROC areas between 0.83 and 0.96) and similarly performed by the two procedures (p = 0.829). The accuracy of specific BIVA was similar in the two sexes (p = 0.144) and in FMDXA% and ECW/ICW (p = 0.869). Conclusions Specific BIVA showed to be an accurate technique. The tolerance ellipses of specific BIVA can be used for evaluating FM% and ECW/ICW in the U.S. adult population. PMID:23484033

  20. Prediction of insulin resistance with anthropometric measures: lessons from a large adolescent population

    Directory of Open Access Journals (Sweden)

    Wedin WK

    2012-07-01

    Full Text Available William K Wedin,1 Lizmer Diaz-Gimenez,1 Antonio J Convit1,21Department of Psychiatry, NYU School of Medicine, New York, NY, USA; 2Nathan Kline Institute, Orangeburg, NY, USAObjective: The aim of this study was to describe the minimum number of anthropometric measures that will optimally predict insulin resistance (IR and to characterize the utility of these measures among obese and nonobese adolescents.Research design and methods: Six anthropometric measures (selected from three categories: central adiposity, weight, and body composition were measured from 1298 adolescents attending two New York City public high schools. Body composition was determined by bioelectric impedance analysis (BIA. The homeostatic model assessment of IR (HOMA-IR, based on fasting glucose and insulin concentrations, was used to estimate IR. Stepwise linear regression analyses were performed to predict HOMA-IR based on the six selected measures, while controlling for age.Results: The stepwise regression retained both waist circumference (WC and percentage of body fat (BF%. Notably, BMI was not retained. WC was a stronger predictor of HOMA-IR than BMI was. A regression model using solely WC performed best among the obese II group, while a model using solely BF% performed best among the lean group. Receiver operator characteristic curves showed the WC and BF% model to be more sensitive in detecting IR than BMI, but with less specificity.Conclusion: WC combined with BF% was the best predictor of HOMA-IR. This finding can be attributed partly to the ability of BF% to model HOMA-IR among leaner participants and to the ability of WC to model HOMA-IR among participants who are more obese. BMI was comparatively weak in predicting IR, suggesting that assessments that are more comprehensive and include body composition analysis could increase detection of IR during adolescence, especially among those who are lean, yet insulin-resistant.Keywords: BMI, bioelectrical impedance

  1. Multifunctional Silk Nerve Guides for Axon Outgrowth

    Science.gov (United States)

    Tupaj, Marie C.

    Peripheral nerve regeneration is a critical issue as 2.8% of trauma patients present with this type of injury, estimating a total of 200,000 nerve repair procedures yearly in the United States. While the peripheral nervous system exhibits slow regeneration, at a rate of 0.5 mm -- 9 mm/day following trauma, this regenerative ability is only possible under certain conditions. Clinical repairs have changed slightly in the last 30 years and standard methods of treatment include suturing damaged nerve ends, allografting, and autografting, with the autograft the gold standard of these approaches. Unfortunately, the use of autografts requires a second surgery and there is a shortage of nerves available for grafting. Allografts are a second option however allografts have lower success rates and are accompanied by the need of immunosuppressant drugs. Recently there has been a focus on developing nerve guides as an "off the shelf" approach. Although some natural and synthetic guidance channels have been approved by the FDA, these nerve guides are unfunctionalized and repair only short gaps, less than 3 cm in length. The goal of this project was to identify strategies for functionalizing peripheral nerve conduits for the outgrowth of neuron axons in vitro . To accomplish this, two strategies (bioelectrical and biophysical) were indentified for increasing axon outgrowth and promoting axon guidance. Bioelectrical strategies exploited electrical stimulation for increasing neurite outgrowth. Biophysical strategies tested a range of surface topographies for axon guidance. Novel methods were developed for integrating electrical and biophysical strategies into silk films in 2D. Finally, a functionalized nerve conduit system was developed that integrated all strategies for the purpose of attaching, elongating, and guiding nervous tissue in vitro. Future directions of this work include silk conduit translation into a rat sciatic nerve model in vivo for the purpose of repairing long

  2. Change with age in regression construction of fat percentage for BMI in school-age children.

    Science.gov (United States)

    Fujii, Katsunori; Mishima, Takaaki; Watanabe, Eiji; Seki, Kazuyoshi

    2011-01-01

    In this study, curvilinear regression was applied to the relationship between BMI and body fat percentage, and an analysis was done to see whether there are characteristic changes in that curvilinear regression from elementary to middle school. Then, by simultaneously investigating the changes with age in BMI and body fat percentage, the essential differences in BMI and body fat percentage were demonstrated. The subjects were 789 boys and girls (469 boys, 320 girls) aged 7.5 to 14.5 years from all parts of Japan who participated in regular sports activities. Body weight, total body water (TBW), soft lean mass (SLM), body fat percentage, and fat mass were measured with a body composition analyzer (Tanita BC-521 Inner Scan), using segmental bioelectrical impedance analysis & multi-frequency bioelectrical impedance analysis. Height was measured with a digital height measurer. Body mass index (BMI) was calculated as body weight (km) divided by the square of height (m). The results for the validity of regression polynomials of body fat percentage against BMI showed that, for both boys and girls, first-order polynomials were valid in all school years. With regard to changes with age in BMI and body fat percentage, the results showed a temporary drop at 9 years in the aging distance curve in boys, followed by an increasing trend. Peaks were seen in the velocity curve at 9.7 and 11.9 years, but the MPV was presumed to be at 11.9 years. Among girls, a decreasing trend was seen in the aging distance curve, which was opposite to the changes in the aging distance curve for body fat percentage.

  3. Carbon emission reduction potentials through thinned wood in Japan

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    Ninomiya H

    2011-06-01

    Full Text Available Substituting fossil fuel with woody biomass for bioelectricity production has great potentials for carbon emission reductions while increasing forest productivity to increase carbon sequestration and improve ecological functionalities. Until recently, study on such potentials was very limited. Beginning in 2007, Japan’s special budgets were allocated for a 6-year intensive thinning on about 3.3 million ha of young stands for increasing carbon sinks in Japanese forests to meet the capped amount of 47.7 Tg CO2 year-1 allowed under the Marrakesh Accord. Because of only 30% of the thinned wood were used for sawntimber, CO2 and CH4 must have been emitted from the disposed thinned wood and wood waste. Such emissions and reduction potentials need to be assessed to provide future alternatives for climate change mitigation. We assessed carbon emission reduction potentials when woody biomass from thinned wood is fully utilized for bioelectricity production as compared with the generation of the same amount of energy produced under coal, oil, and natural gas scenarios. Our analytical results show that if all disposed thinned wood and wood waste are utilized to generate energy, about 62.6, 58.3, and 37.8 Tg CO2 year-1 could be prevented from emitting depending on emission scenarios or about 33.2, 30.9, and 20.0% of Japan’s reduction commitment to the Kyoto Protocol. On the other hand, if thinned wood and wood waste are not utilized, about 13.4 Tg CO2 year-1 would be released due to thinning. Our results suggest that incentives to reducing emission reductions in forest sector in the future climate change mitigation agreements will likely lead to large emission reductions, otherwise leakages due to thinning are unavoidable.

  4. Comparison of two field methods for estimating body fat in different Spanish Dance disciplines

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    José Ramón Alvero-Cruz

    Full Text Available The purpose of the present study was to investigate percentage body fat (%BF differences in three Spanish dance disciplines and to compare skinfold and bioelectrical impedance predictions of body fat percentage in the same sample. Seventy-six female dancers, divided into three groups, Classical (n=23, Spanish (n=29 and Flamenco (n=24, were measured using skinfold measurements at four sites: triceps, subscapular, biceps and iliac crest, and whole body multi-frequency bioelectrical impedance (BIA. The skin-fold measures were used to predict body fat percentage via Durnin and Womersley's and Segal, Sun and Yannakoulia equations by BIA. Differences in percent fat mass between groups (Classical, Spanish and Flamenco were tested by using repeated measures analysis (ANOVA. Also, Pearson's product-moment correlations were performed on the body fat percentage values obtained using both methods. In addition, Bland-Altman plots were used to assess agreement, between anthropometric and BIA methods. Repeated measures analysis of variance did not found differences in %BF between modalities (p<0.05. Fat percentage correlations ranged from r= 0.57 to r=0.97 (all, p<0.001. Bland-Altman analysis revealed differences between BIA Yannakoulia as a reference method with BIA Segal (-0.35 ± 2.32%, 95%CI: -0.89to 0.18, p=0.38, with BIA Sun (-0.73 ± 2.3%, 95%CI: -1.27 to -0.20, p=0.014 and Durnin-Womersley (-2.65 ± 2,48%, 95%CI: -3.22 to -2.07, p<0.0001. It was concluded that body fat percentage estimates by BIA compared with skinfold method were systematically different in young adult female ballet dancers, having a tendency to produce underestimations as %BF increased with Segal and Durnin-Womersley equations compared to Yannakoulia, concluding that these methods are not interchangeable.

  5. Assessment of volume depletion in children with malaria.

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    Timothy Planche

    2004-10-01

    Full Text Available BACKGROUND: The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartments reflect disease severity, we measured body compartment volumes in Gabonese children with malaria. METHODS AND FINDINGS: Total body water volume (TBW and extracellular water volume (ECW were estimated in children with severe or moderate malaria and in convalescence by tracer dilution with heavy water and bromide, respectively. Intracellular water volume (ICW was derived from these parameters. Bioelectrical impedance analysis estimates of TBW and ECW were calibrated against dilution methods, and bioelectrical impedance analysis measurements were taken daily until discharge. Sixteen children had severe and 19 moderate malaria. Severe childhood malaria was associated with depletion of TBW (mean [SD] of 37 [33] ml/kg, or 6.7% [6.0%] relative to measurement at discharge. This is defined as mild dehydration in other conditions. ECW measurements were normal on admission in children with severe malaria and did not rise in the first few days of admission. Volumes in different compartments (TBW, ECW, and ICW were not related to hyperlactataemia or other clinical and laboratory markers of disease severity. Moderate malaria was not associated with a depletion of TBW. CONCLUSIONS: Significant hypovolaemia does not exacerbate complications of severe or moderate malaria. As rapid rehydration of children with malaria may have risks, we suggest that fluid replacement regimens should aim to correct fluid losses over 12-24 h.

  6. Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.

    Science.gov (United States)

    Pezzulo, G; Levin, M

    2015-12-01

    A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configurations, rules, and patterns) and coordinate their activity towards proximal and distant goals. In this Perspective, we propose that programming large-scale morphogenesis requires exploiting the information processing by which cellular structures work toward specific shapes. In non-neural cells, as in the brain, bioelectric signaling implements information processing, decision-making, and memory in regulating pattern and its remodeling. Thus, approaches used in computational neuroscience to understand goal-seeking neural systems offer a toolbox of techniques to model and control regenerative pattern formation. Here, we review recent data on developmental bioelectricity as a regulator of patterning, and propose that target morphology could be encoded within tissues as a kind of memory, using the same molecular mechanisms and algorithms so successfully exploited by the brain. We highlight the next steps of an unconventional research program, which may allow top-down control of growth and form for numerous applications in regenerative medicine and synthetic bioengineering.

  7. System for measuring electric resistance skin

    Directory of Open Access Journals (Sweden)

    V. P. Kutsenko

    2015-09-01

    Full Text Available Introduction. To measure the electrical resistance of leather frequently used system for applying testing signals from external current sources or voltage. Power testing signals the maximum limit, when they Electro studies still have a negative impact on the human body. Formulation of the problem. To achieve this task the authors conducted research and developed a system, which is based to measure electrical skin resistance (ESR responsible allocation and measurement noise variance bioelectric signal is proportional to the resistance area of research. Main body. The paper studied and developed a system, based on measuring electrical skin resistance on the identification and measurement of the noise variance from the BAP bioelectric signal that is proportional to the resistance of the investigation. A functional block diagram of an automated algorithm for converting the useful and noise signal BAP, whose range does not differ fundamentally from those of the intrinsic noise of the input elements in ESR. The proposed method will improve the accuracy of the measurements ESR without the use of test pacing signal. The simulation results and experimental studies correlate that confirms the adequacy of this method the results of experimental measurements. Conclusions. For noise voltage BAT can measure their electrical resistance without signals tested, external sources of electric current or voltage and thereby completely eliminate the harmful effect of probing. Thanks to one of the Inverting periodic noise voltages multiplied and simultaneous detection variable component switching frequency, provided the allocation and measurement noise voltage acupuncture points, which is proportional to the resistance, and the intensity of the same order or less than the intrinsic noise of the measuring system. Use as medical acupuncture needle electrodes allows to measure not only the skin but also deep resistivity, which reflects the physiological state of internal

  8. 肿瘤患者机体组成及肌肉减少症的调查%Observational research on body composition and sarcopenia in patients with tumor

    Institute of Scientific and Technical Information of China (English)

    吴焱; 凌轶群; 丁慧萍; 钱泳; 汪琼

    2016-01-01

    Objective:To observe body composition and the occurrence of sarcopenia in tumor patients so as to provide evidence for the early monitoring of their nutritional status .Methods:Bioelectrical impedance analysis(BIA) was adopted to analyze the body composition and appendicular skeletal muscle mass index (ASMI) was used to observe the occurrence of sarcopenia to explore the relationship between BMI and sarcopenia in 224 patients with tumor .The body composition of 224 cases of tumor patients was analyzed by bioelectrical impedance analysis(BIA) .The occurrence of sarcopenia was observed with appendicular skeletal mass index (ASMI) ,and the relationship between body mass index (BMI) and sarcopenia was also explored .Results:In 224 tumor patients ,13 .4% (30/224) were underweight ,60 .7% (136/224) were normal weight and 25 .9% (58/224) were overweight or obese .The incidence of sarcopenia was 58 .04% (130/224) ,and 77 .7% (101/130) of the patients with sarcopenia were normal ,overweight or obese .Conclusions:The change of the muscle and its function in cancer patients is as noteworthy as weight loss .Body composition of cancer patients should be timely monitored in order to optimize nutritional risk screening , establish individualized nutritional support , and develop the treatment plan with best tolerance .%目的:观察肿瘤患者的机体组成和肌肉减少症(sarcopenia)的发生情况,为尽早监测肿瘤患者的营养状况提供依据。方法:采用生物电阻抗法(bioelectrical impedance analysis ,BIA )分析224例肿瘤患者的机体组成,利用四肢骨骼肌指数(appendicular skeletal mass index ,ASMI)观察肌肉减少症的发生情况,并探究肿瘤患者体质指数(BMI)与肌肉减少症的关系。结果:224例肿瘤患者中13.4%(30/224)为消瘦,60.7%(136/224)为正常体质量,25.9%(58/224)为超重或肥胖。肌肉减少症发生率为58.04%(130/224) ,77.7

  9. Nutritional parameters are associated with mortality in acute kidney injury

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    Marina Nogueira Berbel

    2014-07-01

    Full Text Available OBJECTIVE:The objective of this study was to perform a nutritional assessment of acute kidney injury patients and to identify the relationship between nutritional markers and outcomes.METHOD:This was a prospective and observational study. Patients who were hospitalized at the Hospital of Botucatu School of Medicine were evaluated between January 2009 and December 2011. We evaluated a total of 133 patients with a clinical diagnosis of acute kidney injury and a clinical presentation suggestive of acute tubular necrosis. We explored the associations between clinical, laboratory and nutritional markers and in-hospital mortality. Multivariable logistic regression was used to adjust for confounding and selection bias.RESULTS:Non-survivor patients were older (67±14 vs. 59±16 years and exhibited a higher prevalence of sepsis (57.1 vs. 21.4% and higher Acute Tubular Necrosis-Individual Severity Scores (0.60±0.22 vs. 0.41±0.21 than did survivor patients. Based on the multivariable analysis, laboratorial parameters such as blood urea nitrogen and C-reactive protein were associated with a higher risk of death (OR: 1.013, p= 0.0052; OR: 1.050, p= 0.01, respectively, and nutritional parameters such as low calorie intake, higher levels of edema, lower resistance based on bioelectrical impedance analysis and a more negative nitrogen balance were significantly associated with a higher risk of death (OR: 0.950, p= 0.01; OR: 1.138, p= 0.03; OR: 0.995, p= 0.03; OR: 0.934, p= 0.04, respectively.CONCLUSIONS:In acute kidney injury patients, a nutritional assessment seems to identify nutritional markers that are associated with outcome. In this study, a low caloric intake, higher C-reactive protein levels, the presence of edema, a lower resistance measured during a bioelectrical impedance analysis and a lower nitrogen balance were significantly associated with risk of death in acute kidney injury patients.

  10. Phasic oscillations of extracellular potassium (K(o in pregnant rat myometrium.

    Directory of Open Access Journals (Sweden)

    Roger C Young

    Full Text Available K-sensitive microelectrodes were used to measure K(+ within the extracellular space (K(o of pregnant rat myometrium. Contractile activity was monitored by measuring either force or bioelectrical signals. Single and double-barreled electrodes were used. Double-barreled electrodes allowed monitoring of electrical activity 15 microns from the site of K(o measurement. From double-barreled electrode experiments, the bioelectrical burst started first, and then K(o began to rise 0.6 ± 0.1 seconds later. This delay indicates that K(+ leaves the cells in response to local electrical activity rather than vice versa. Four control experiments were performed to assess the influence of electrical artifacts caused by tissue motion on K(o values. When observed, artifacts were negative and transient, and hence would result in an underestimation of K(o rises. Artifacts were minimized when tissue motion was minimized by fixing the tissue at both ends. At 37°C, 7 single barreled experiments and 45 contractions were analyzed. Resting K(o was within 1 mM of bath K(+ (5 mM at the beginning and end of the experiments. K(o rose during the contraction, fell after the completion of the contraction, and normalized before the next contraction began. Peak K(o values observed during force production were 18.8 ± 5.9 mM, a value high enough to modulate tissue-level electrical activity. K(o required 15.7 ± 2.8 seconds to normalize halfway (t50. Six experiments expressing 38 contractions were performed at 24°C. The contraction period was longer at 24°C. Values for peak K(o (26.2 ± 9.9 mM and t50 (29.8±16.2 sec were both larger than at 37°C (p<0.0003 for both. The direct relationships between peak K(o, t50 and the contraction period, suggest elevations in K(o may modulate contraction frequency. The myometrial interstitial space appears to be functionally important, and K(o metabolism may participate in cell-cell interactions.

  11. Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium.

    Science.gov (United States)

    Mistry, Alpesh; Stolnik, Snjezana; Illum, Lisbeth

    2015-08-03

    The ability to deliver therapeutically relevant amounts of drugs directly from the nasal cavity to the central nervous system to treat neurological diseases is dependent on the availability of efficient drug delivery systems. Increased delivery and/or therapeutic effect has been shown for drugs encapsulated in nanoparticles; however, the factors governing the transport of the drugs and/or the nanoparticles from the nasal cavity to the brain are not clear. The present study evaluates the potential transport of nanoparticles across the olfactory epithelium in relation to nanoparticle characteristics. Model systems, 20, 100, and 200 nm fluorescent carboxylated polystyrene (PS) nanoparticles that were nonmodified or surface modified with polysorbate 80 (P80-PS) or chitosan (C-PS), were assessed for transport across excised porcine olfactory epithelium mounted in a vertical Franz diffusion cell. Assessment of the nanoparticle content in the donor chamber of the diffusion cell, accompanied by fluorescence microscopy of dismounted tissues, revealed a loss of nanoparticle content from the donor suspension and their association with the excised tissue, depending on the surface properties and particle size. Chitosan surface modification of PS nanoparticles resulted in the highest tissue association among the tested systems, with the associated nanoparticles primarily located in the mucus, whereas the polysorbate 80-modified nanoparticles showed some penetration into the epithelial cell layer. Assessment of the bioelectrical properties, metabolic activity, and histology of the excised olfactory epithelium showed that C-PS nanoparticles applied in pH 6.0 buffer produced a damaging effect on the epithelial cell layer in a size-dependent manner, with fine 20 nm sized nanoparticles causing substantial tissue damage relative to that with the 100 and 200 nm counterparts. Although histology showed that the olfactory tissue was affected by the application of citrate buffer that was

  12. Methods in Analyzing Abdominal Fat of Obese Children and Adolescents%肥胖儿童青少年腹部脂肪不同评价方法比较

    Institute of Scientific and Technical Information of China (English)

    郑小斐; 汤庆娅; 陶晔璇

    2009-01-01

    Objectives To assess the clinical value of ultrasonography (US) and bioelectrical impedance analysis (BIA) in analyzing abdominal fat contents of obese children and adolescents through comparison with MRI. A correlation with other obese related metabolic parameters was conducted. Methods Ninety 7-17-y-old obese children and adolescents (60 boys and 30 girls with mean age of 9.6 ± 2.9 y and mean BMI of 24.5 ± 4.5 kg/m2) were recruited. Metabolic parameters were measured, and insulin resistance was estimated according to homeostasis model assess-ment (HOMA-IR). On the same day abdomen subcutaneous fat thickness (SFTUS) was measured by US. Body fat mass (FMBIA) and abdominal visceral fat area (VFABIA) were analyzed by bioelectrical impedance analysis (BIA). After obtaining informed consent, abdominal MRI was performed in 20 subjects. Each section of umbilicus level was analyzed by image threshold value segmentation using SigmaScan Pro 5 and abdominal subcutaneous fat area (SFAMRI) and visceral fat area (VFAMRI) were calculated. Results (1) A strong positive association was found between SFTUS and SFAMRI (P< 0.05), VFABIA and VFAMRI (P < 0.01) respectively. (2) FMBIA and SFAMRI, VFAMRI, SFTUS also showed significant correlations (P < 0.05). (3) VFAMRI showed extremely significant positive correlations with TG, Insulin,C-peptide and HOMA-IR (P < 0.01 ) ; SFAMRI was also correlated positively with them (P < 0.05). (4) SFTUS was correlated positively with UA (uric acid), Insulin, 2HIns (insulin measured at 2 hours after meal), C-peptide,2HC-peptide (C-peptide measured at 2 hours after meal) and HOMA-IR (P < 0.01). (5) VFABIA was correlated significant positively with UA, insulin, TG, 2HIns and HOMA-IR. FMBIA showed positive correlation with UA, Insulin,2HIns, C-peptide, 2HC-peptide and HOMA-IR. Conclusions abdominal subcutaneous and visceral fat of obese children and adolescents evaluated by US and BIA are correlated well with those assessed by MRI, and also correlated

  13. Prediction of RBC aggregability and deformability by whole body bioimpedance measurements analyzed according to Hanai's mixture conductivity theory.

    Science.gov (United States)

    Varlet-Marie, Emmanuelle; Brun, Jean-Frédéric

    2011-01-01

    Bioelectrical impedancemetry (BIA) has been used to evaluate hemorheological parameters in vitro, and whole body impedance measurements are also correlated to some hemorheologic factors, due to their close relationship with determinants of electric properties of blood. In previous studies, we have determined a set of predictive equations for hematocrit, whole blood viscosity and plasma viscosity in both sedentary and trained individuals. Recent developments of the interpretation of BIA analysis based on Hanai's mixture conductivity theory allows a more interpretative analysis of the relationships between these electric measurements and body composition. Impedance can be analyzed in terms of resistance and resistivity of the whole body and even more, assuming some simplifications, resistance R and resistivity ρ of total body water (TBW), extracellular water (ECW) and intracellular water (ICW). In this study we thus investigated relationships between blood rheology and these calculations of R and ρ in a sample of 83 subjects (age: 9-64 yr; BMI: 17-44 kg/m(2)). BIA was performed with a multifrequency bioelectrical impedancemeter using low intensity at the following frequencies: 1, 5, 10, 50 and 100 kHz. Viscometric measurements were done with a falling ball viscometer. Hematocrit was measured with microcentrifuge. We found a new prediction of Quemada's viscometric index of RBC rigidity "k" which was positively correlated to the resistance of ECW (R(e)) and even more if it was related to this volume: k = 0.005809 R(e)/ECW + 1.1784 (r = 0.487; Bland-Altman mean difference: 0.0124; range: -0.00481 to 0.00296). A new finding was that red blood cells (RBC) aggregability, that in the previous studies was not related to whole body impedance, despite its in vitro measurability with such measurements, was correlated to extracellular resistance and resistivity. The Myrenne index "M" was negatively correlated to the resistivity of the extracellular fluid ρe and is predicted

  14. Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

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    Baeg MK

    2015-10-01

    Full Text Available Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of KoreaBackground: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM, which is an integral component of sarcopenia.Materials and methods: Healthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002. Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013 was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051 had a preventive tendency.Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.Keywords: sarcopenia, Helicobacter

  15. Comparison of Two Different Modes of Active Recovery on Muscles Performance after Fatiguing Exercise in Mountain Canoeist and Football Players

    Science.gov (United States)

    Mika, Anna; Oleksy, Łukasz; Kielnar, Renata; Wodka-Natkaniec, Ewa; Twardowska, Magdalena; Kamiński, Kamil; Małek, Zbigniew

    2016-01-01

    Background The aim of this study is to assess if the application of different methods of active recovery (working the same or different muscle groups from those which were active during fatiguing exercise) results in significant differences in muscle performance and if the efficiency of the active recovery method is dependent upon the specific sport activity (training loads). Design A parallel group non-blinded trial with repeated measurements. Methods Thirteen mountain canoeists and twelve football players participated in this study. Measurements of the bioelectrical activity, torque, work and power of the vastus lateralis oblique, vastus medialis oblique, and rectus femoris muscles were performed during isokinetic tests at a velocity of 90°/s. Results Active legs recovery in both groups was effective in reducing fatigue from evaluated muscles, where a significant decrease in fatigue index was observed. The muscles peak torque, work and power parameters did not change significantly after both modes of active recovery, but in both groups significant decrease was seen after passive recovery. Conclusions We suggest that 20 minutes of post-exercise active recovery involving the same muscles that were active during the fatiguing exercise is more effective in fatigue recovery than active exercise using the muscles that were not involved in the exercise. Active arm exercises were less effective in both groups which indicates a lack of a relationship between the different training regimens and the part of the body which is principally used during training. PMID:27706260

  16. Standardized surgical approaches to ear surgery in rats

    Institute of Scientific and Technical Information of China (English)

    Peng Li; Dalian Ding; Kelei Gao; Richard Salvi

    2015-01-01

    Objective:To describe several approaches of ear surgeries for experimental studies in rats. Methods:Anesthetized rats were prepared for demonstration of various ear surgery approaches designed to optimize experimental outcomes in studies with specific goals and exposure requirements. The surgical approaches included the posterior tympanum, superior tympanum, inferior tympanum and occipital approaches. Results: The middle ear cavity and inner ear were successfully exposed from different angles via the mentioned surgical approaches. For example, electrode placement for recording of cochlear bioelectric responses was easily achieved through the posterior tympanum or inferior tympanum approach. Alternatively, drug delivery or gene transfection via round window membrane was most easily accomplished using the posterior tympanum approach. Cochlear perfusion of protective or ototoxic drugs was best performed using the inferior tympanum approach. Ossicular chain interruption to induce a prolonged conductive hearing loss was readily achieved using a superior tympanum approach. Lastly, surgical destruction of the endolymphatic sac to induce experimental endolymphatic hydrops was readily performed via an occipital surgical approach. Conclusion: These standardized surgical approaches can be applied in scientific studies of the ear with different purposes covering electro-physiology, conductive hearing loss, intra-cochlear drug perfusion and experimental studies relevant to Meniere's disease.

  17. Infrared thermography for indirect assessment of activation of brown adipose tissue in lean and obese male subjects.

    Science.gov (United States)

    El Hadi, Hamza; Frascati, Andrea; Granzotto, Marnie; Silvestrin, Valentina; Ferlini, Elisabetta; Vettor, Roberto; Rossato, Marco

    2016-12-01

    Brown adipose tissue (BAT) plays a key role in adaptive thermogenesis in mammals, and it has recently been considered as an attractive therapeutic target for tackling human obesity by increasing energy expenditure. Thermal imaging using infrared thermography (IRT) has emerged as a potential safe, rapid and inexpensive technique for detecting BAT in humans. However, little attention has been given to the reliability of this method in obese subjects. To this end, we evaluated the capacity of IRT to detect activated supraclavicular (SCV) BAT in 14 lean and 16 mildly obese young adults after acute cold exposure. Using IRT we measured the temperature of the skin overlying the SCV and sternal areas at baseline and after acute cold stimulation. Additionally, energy expenditure was measured by indirect calorimetry and body composition was estimated using bioelectrical impedance analysis. Energy expenditure and SCV skin temperature significantly increased in lean subjects upon cold exposure, while no significant changes were detected in the obese group. Furthermore, cold-induced variations in SCV skin temperature of obese subjects showed a negative correlation with body mass index. This study suggests that in lean individuals BAT is a rapidly activated thermogenic tissue possibly involved in the regulation of energy balance, and can be indirectly assessed using IRT. In obese subjects, BAT seems less prone to be activated by cold exposure, with the degree of adiposity representing a limiting factor for the indirect detection of BAT activation by measuring the skin temperature overlying BAT.

  18. Do patients with mild to moderate psoriasis really have a sedentary lifestyle?

    Science.gov (United States)

    Demirel, Reha; Genc, Abdurrahman; Ucok, Kagan; Kacar, Seval Dogruk; Ozuguz, Pinar; Toktas, Muhsin; Sener, Umit; Karabacak, Hatice; Karaca, Semsettin

    2013-09-01

    The aim of this study was to compare aerobic exercise capacity, daily physical activity, pulmonary functions, resting metabolic rate, and body composition parameters in patients with psoriasis and healthy controls. A total of 60 participants (30 [15 men, 15 women] patients with psoriasis, and 30 [15 men, 15 women] healthy controls) ranging in age from 22-57 were included in the study. Maximal aerobic capacity was determined by Astrand exercise protocol. Daily physical activity was measured with an accelerometer. Resting metabolic rate was determined with an indirect calorimeter. Pulmonary function tests were performed with a portable spirometer. Body composition was established with a bioelectric impedance analysis system. Skinfold thicknesses and body circumference measurements were carried out. Short Form 36 quality of life questionnaire was applied to all participants. In both genders, daily physical activity parameters were found to be higher in the psoriasis group compared to the control. Maximal aerobic capacity, resting metabolic rate, pulmonary function tests, body fatness, body fat distributions, and quality of life were not statistically different between patients with psoriasis and controls in males and females. We suggest that patients with psoriasis who do not have psoriatic arthritis or severe psoriasis are well in performing daily physical activities. In addition, we suggest that this lifestyle helped to prevent impairments of body fatness, body fat distributions, resting metabolic rate, pulmonary functions, and quality of life in patients with mild to moderate psoriasis.

  19. MHG bioenergy ERP - enterprise resource planning service entity for bioenergy operators

    Energy Technology Data Exchange (ETDEWEB)

    Huurinainen, S. (MHG Systems Oy Ltd, Mikkeli (Finland)), Email: seppo.huurinainen@mhgsystems.com

    2009-07-01

    MHG Systems provides ERP systems specifically geared for the bioenergy and energy field. MHG ERP synthesizes mobile communications, the Internet, real-time maps, and satellite-based location information into one business-enhancing service and allows the use of new and especially contract-based and empowering operational models. The company's services bring significant cost savings to all operators in the bioheat, bioelectricity, and biofuel production chain. The MHG platform service allows development of new, empowering operational models resulting in paperfree office and field work. Customer solutions are created from MHG ERP's building blocks and delivered as turnkey solutions - or the service can be used an ASP basis. MHG customer solutions are created from MHG ERP's independent building blocks and delivered as turnkey solutions, or the service can be used on an ASP basis. MHG-ERP-based customer solutions can be used practically anywhere in the world, since they can be set to utilize national raster maps. professional vector-based Google Maps products, or remote sensing maps and are used via a Web browser or online or offline mobile devices such as smartphones, automatic navigators, PDAs, Toughbooks, and PCs. The superior features of the MGH Bioenergy ERP service include transparency throughout the delivery chain, management of the moisture content of bioenergy masses, reporting features focused on the amount of energy (i.e., the number of megawatt hours), and accounts and invoicing. (orig.)

  20. Association of Body Composition with Curve Severity in Children and Adolescents with Idiopathic Scoliosis (IS).

    Science.gov (United States)

    Matusik, Edyta; Durmala, Jacek; Matusik, Pawel

    2016-01-28

    The link between scoliotic deformity and body composition assessed with bioimpedance (BIA) has not been well researched. The objective of this study was to correlate the extent of scoliotic-curve severity with the anthropometrical status of patients with idiopathic scoliosis (IS) based on standard anthropometric measurements and BIA. The study encompassed 279 IS patients (224 girls/55 boys), aged 14.21 ± 2.75 years. Scoliotic curve severity assessed by Cobb's angle was categorized as moderate (10°-39°) or severe (≥40°). Corrected height, weight, waist and hip circumferences were measured and body mass index (BMI), corrected height z-score, BMI Z-score, waist/height ratio (WHtR) and waist/hip ratio (WHR) were calculated for the entire group. Body composition parameters: fat mass (FAT), fat-free mass (FFM) and predicted muscle mass (PMM) were determined using a bioelectrical impedance analyzer. The mean Cobb angle was 19.96° ± 7.92° in the moderate group and 52.36° ± 12.54° in the severe group. The corrected body heights, body weights and BMIs were significantly higher in the severe IS group than in the moderate group (p children.

  1. Finite-element-based discretization and regularization strategies for 3-D inverse electrocardiography.

    Science.gov (United States)

    Wang, Dafang; Kirby, Robert M; Johnson, Chris R

    2011-06-01

    We consider the inverse electrocardiographic problem of computing epicardial potentials from a body-surface potential map. We study how to improve numerical approximation of the inverse problem when the finite-element method is used. Being ill-posed, the inverse problem requires different discretization strategies from its corresponding forward problem. We propose refinement guidelines that specifically address the ill-posedness of the problem. The resulting guidelines necessitate the use of hybrid finite elements composed of tetrahedra and prism elements. Also, in order to maintain consistent numerical quality when the inverse problem is discretized into different scales, we propose a new family of regularizers using the variational principle underlying finite-element methods. These variational-formed regularizers serve as an alternative to the traditional Tikhonov regularizers, but preserves the L(2) norm and thereby achieves consistent regularization in multiscale simulations. The variational formulation also enables a simple construction of the discrete gradient operator over irregular meshes, which is difficult to define in traditional discretization schemes. We validated our hybrid element technique and the variational regularizers by simulations on a realistic 3-D torso/heart model with empirical heart data. Results show that discretization based on our proposed strategies mitigates the ill-conditioning and improves the inverse solution, and that the variational formulation may benefit a broader range of potential-based bioelectric problems.

  2. Glucose homeostasis can be differentially modulated by varying individual components of a western diet.

    Science.gov (United States)

    Forbes, Josephine M; Cowan, Samantha P; Andrikopoulos, Sofianos; Morley, Amy L; Ward, Leigh C; Walker, Karen Z; Cooper, Mark E; Coughlan, Melinda T

    2013-07-01

    Chronic overconsumption of a Western diet has been identified as a major risk factor for diabetes, yet precisely how each individual component contributes to defects in glucose homeostasis independent of consumption of other macronutrients remains unclear. Eight-week-old male Sprague Dawley rats were randomized to feeding with one of six semi-pure diets: control, processed (high advanced glycation end products/AGE), high protein, high dextrose (glucose polymer), high in saturated fat (plant origin), or high in saturated fat (animal origin). After chronic feeding for 24 weeks, body composition was determined by bioelectrical impedance spectroscopy and glucose homeostasis was assessed. When compared to the control and high AGE diets, excess consumption of the diet high in saturated fat (animal source) increased body weight and adiposity, and decreased insulin sensitivity, as defined by HOMA IR, impaired skeletal muscle insulin signaling and insulin hypersecretion in the context of increased circulating glucagon-like peptide (GLP-1). Compared to the control diet, chronic consumption of the high AGE, protein or dextrose diet increased fasting plasma glucose, decreased fasting plasma insulin and insulin secretion. These diets also reduced circulating GLP-1 concentrations. These data suggest that individual components of a western diet have differential effects in modulating glucose homeostasis and adiposity. These data provide clear evidence of a link between over-consumption of a western diet and the development of diabetes.

  3. Development of a high-resolution apparatus to monitor physiological state of a person undergoing extreme conditions

    Directory of Open Access Journals (Sweden)

    Kodermyatov Radik

    2016-01-01

    Full Text Available The present research has shown that ECG recordings and parameters of the body functional state are crucial for all kinds of the astronaut pre-flight preparations (centrifuge, thermal chamber, pressure chamber, pressure chamber with special equipment. It is, therefore, important to develop methods and tools for early detection of the preclinical forms of the functional state disorders in patients undergoing high-intensity loads of mixed character. The method based on the hardware-software compleх (HSC with nanosensors of high resolution has been proposed to measure the electrophysiological characteristics and bioelectrical impedance of the body tissues directly exposed to loading. The hardware-software compleх is subjected to clinical trials in Tomsk Research Institute for Cardiology. The obtained results show that the use of nanosensors of high resolution in the HSC without standard filters allows elimination of the power-line interference in ECG recordings. Monitoring of the tissue bioimpedance parameters under test loads enables the detection of preclinical (latent forms of various diseases. After clinical trials in Tomsk Institute for Cardiology the developed apparatus will be proposed for in-depth study of the cardiovascular system and the functional state of the body of astronauts and other persons exposed to extreme loads.

  4. The Effects of Compliance with Nutritional Counselling on Body Composition Parameters in Head and Neck Cancer Patients under Radiotherapy

    Science.gov (United States)

    Ozkaya Akagunduz, O.; Meseri Dalak, R.; Esassolak, M.; Uyar, M.

    2017-01-01

    Background. Radiotherapy (RT) has been associated with increased risk of malnutrition in cancer patients, particularly in those with head and neck cancer (HNC). The aim of this prospective study was to evaluate the effects of compliance of patients with individual dietary counselling on body composition parameters in HNC patients under RT. Material and Methods. Sixty-nine consecutive patients (mean age: 61.0 ± 13.8) were prospectively followed. Bioelectrical impedance analysis (BIA) was performed to determine body composition parameters before, in the middle of, and at the end of RT. All patients received nutritional counselling and majority of them (94.6%) received oral nutritional supplement (ONS) during RT or chemoradiotherapy. If a patient consumed ≥75% of the recommended energy and protein intake via ONS and regular food, he/she was considered to be “compliant” (n = 18), while those who failed to meet this criteria were considered to be “noncompliant” (n = 30). Results. Body mass index, weight, fat percentage, fat mass, fat free mass, and muscle mass did not decrease significantly over time in compliant patients, but in noncompliant patients, all of these indices decreased significantly from baseline compared to the end of treatment (p patients (11.1% versus 88.9%, resp.) (p patients considered as compliant with nutritional counselling than noncompliant ones during RT period. PMID:28116152

  5. Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (parenteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting

    Directory of Open Access Journals (Sweden)

    Cocchieri Riccardo

    2011-03-01

    Full Text Available Abstract Background Malnutrition is very common in patients undergoing cardiac surgery. Malnutrition can change myocardial substrate utilization which can induce adverse effects on myocardial metabolism and function. We aim to investigate the hypothesis that there is a disturbed amino acids profile in the cardiac surgical patient which can be normalized by (parenteral nutrition before, during and after surgery, subsequently improving cardiomyocyte structure, cardiac perfusion and glucose metabolism. Methods/Design This randomized controlled intervention study investigates the effect of uninterrupted perioperative (parenteral nutrition on cardiac function in 48 patients undergoing coronary artery bypass grafting. Patients are given enteral nutrition (n = 16 or parenteral nutrition (n = 16, at least two days before, during, and two days after coronary artery bypass grafting, or are treated according to the standard guidelines (control (n = 16. We will illustrate the effect of (parenteral nutrition on differences in concentrations of amino acids and asymmetric dimethylarginine and in activity of dimethylarginine dimethylaminohydrolase and arginase in cardiac tissue and blood plasma. In addition, cardiomyocyte structure by histological, immuno-histochemical and ultrastructural analysis will be compared between the (parenteral and control group. Furthermore, differences in cardiac perfusion and global left ventricular function and glucose metabolism, and their changes after coronary artery bypass grafting are evaluated by electrocardiography-gated myocardial perfusion scintigraphy and 18F-fluorodeoxy-glucose positron emission tomography respectively. Finally, fat free mass is measured before and after intervention with bioelectrical impedance spectrometry in order to evaluate nutritional status. Trial registration Netherlands Trial Register (NTR: NTR2183

  6. Comparison of Balance, Proprioception and Skeletal Muscle Mass in Total Hip Replacement Patients With and Without Fracture: A Pilot Study

    Science.gov (United States)

    2016-01-01

    Objective To determine whether there was a difference in balance, proprioception, and skeletal muscle mass among patients who undergo hip fracture surgery relative to and elective total hip replacement (THR). Methods Thirty-one THR patients were enrolled. The patients were categorized into two groups: fracture group (n=15) and non-fracture group (n=16). Berg Balance Scale (BBS) was used to balance the proprioception of the hip joint while a joint position sense (JPS) test was used to evaluate it. Skeletal muscle mass was measured by bioelectrical impedance analysis and expressed as a skeletal muscle mass index (SMI). Quality of life (QOL) was also assessed using a 36-item short form health survey (SF-36). All tests were assessed at 3 months after the surgery. An independent t-test was used to compare the fracture group and non-fracture group. Spearman correlation was used to identify the correlation of each variable. Results In an independent t-test, the BBS score of patients undergoing elective surgery was higher than the BBS score of patients undergoing hip fracture surgery. There was a significant correlation between the BBS and JPS score after a THR. SMI also correlated with the score of BBS. Conclusion It seems that THR patients undergoing surgery for a hip fracture might have more trouble balancing than elective THR patients. Therefore THR patients undergoing hip fracture surgery might need more care during rehabilitation. PMID:28119837

  7. Cajal bodies in neurons.

    Science.gov (United States)

    Lafarga, Miguel; Tapia, Olga; Romero, Ana M; Berciano, Maria T

    2016-09-14

    Cajal is commonly regarded as the father of modern neuroscience in recognition of his fundamental work on the structure of the nervous system. But Cajal also made seminal contributions to the knowledge of nuclear structure in the early 1900s, including the discovery of the "accessory body" later renamed "Cajal body" (CB). This important nuclear structure has emerged as a center for the assembly of ribonucleoproteins (RNPs) required for splicing, ribosome biogenesis and telomere maintenance. The modern era of CB research started in the 1990s with the discovery of coilin, now known as a scaffold protein of CBs, and specific probes for small nuclear RNAs (snRNAs). In this review, we summarize what we have learned in the recent decades concerning CBs in post-mitotic neurons, thereby ruling out dynamic changes in CB functions during the cell cycle. We show that CBs are particularly prominent in neurons, where they frequently associate with the nucleolus. Neuronal CBs are transcription-dependent nuclear organelles. Indeed, their number dynamically accommodates to support the high neuronal demand for splicing and ribosome biogenesis required for sustaining metabolic and bioelectrical activity. Mature neurons have canonical CBs enriched in coilin, survival motor neuron protein and snRNPs. Disruption and loss of neuronal CBs associate with severe neuronal dysfunctions in several neurological disorders such as motor neuron diseases. In particular, CB depletion in motor neurons seems to reflect a perturbation of transcription and splicing in spinal muscular atrophy, the most common genetic cause of infant mortality.

  8. EFFECTS OF BODY MASS-BASED SQUAT TRAINING IN ADOLESCENT BOYS

    Directory of Open Access Journals (Sweden)

    Yohei Takai

    2013-03-01

    Full Text Available The purpose of this study was to determine the effects of body mass-based squat training on body composition, muscular strength and motor fitness in adolescent boys. Ninety-four boys (13.7 ± 0.6 yrs, 1.60 ± 0.09 m, 50.2 ± 9.6 kg participated in this study and were randomly assigned to training (n = 36 or control (n = 58 groups. The training group completed body mass-based squat exercise training (100 reps/day, 45 sessions for 8 weeks. Body composition and muscle thickness at the thigh anterior were determined by a bioelectrical impedance analyzer and ultrasound apparatus, respectively. Maximal voluntary knee extension strength and sprint velocity were measured using static myometer and non-motorized treadmill, respectively. Jump height was calculated using flight time during jumping, which was measured by a matswitch system. The 8-wk body mass-based squat training significantly decreased percent body fat (4.2% and significantly increased the lean body mass (2.7%, muscle thickness (3.2% and strength of the knee extensors (16.0%, compared to control group. The vertical jump height was also significantly improved by 3.4% through the intervention. The current results indicate that body mass-based squat training for 8 weeks is a feasible and effective method for improving body composition and muscular strength of the knee extensors, and jump performance in adolescent boys.

  9. Clinically relevant determinants of body composition, function and nutritional status as mortality predictors in lung cancer patients.

    Science.gov (United States)

    Kovarik, Miroslav; Hronek, Miloslav; Zadak, Zdenek

    2014-04-01

    Lung cancer belongs to the type of tumors with a relatively high frequency of malnutrition, sarcopenia and cachexia, severe metabolic syndromes related to impairment of physical function and quality of life, resistance to therapy and short survival. Inexpensive and accessible methods of evaluating changes in body composition, physical function and nutrition status are for this reason of great importance for clinical practice to enable the early identification, monitoring, preventing and treatment of these nutritional deficiencies. This could lead to improved outcomes in the quality of life, physical performance and survival of patients with lung cancer. The aim of this article is to summarize the recent knowledge for the use of such methods, their predictability for patient outcomes and an association with other clinically relevant parameters, specifically with lung cancer patients, because such an article collectively describing their practical application in clinical practice is lacking. The interest of this article is in the use of anthropometry, handgrip dynamometry, bioelectrical impedance analysis derived phase angle and nutritional screening questionnaires in lung cancer patients.

  10. Synchronization dynamics induced on pairs of neurons under applied weak alternating magnetic fields.

    Science.gov (United States)

    Azanza, María J; del Moral, A; Calvo, A C; Pérez-Bruzón, R N; Junquera, C

    2013-12-01

    Pairs of Helix aspersa neurons show an alternating magnetic field dependent frequency synchronization (AMFS) when exposed to a weak (amplitude B0 between 0.2 and 150 Gauss (G)) alternating magnetic field (AMF) of extremely low frequency (ELF, fM = 50 Hz). We have compared the AMFS patterns of discharge with: i) the synaptic activity promoted by glutamate and acetylcholine; ii) the activity induced by caffeine; iii) the bioelectric activity induced on neurons interconnected by electric synapses. AMFS activity reveals several specific features: i) a tight coincidence in time of the pattern and frequency, f, of discharge; ii) it is induced in the time interval of field application; iii) it is dependent on the intensity of the sinusoidal applied magnetic field; iv) elicited biphasic responses (excitation followed by inhibition) run in parallel for the pair of neurons; and v) some neuron pairs either spontaneously or AMF synchronized can be desynchronized under applied higher AMF. Our electron microscopy studies reveal gap-like junctions confirming our immunocytochemistry results about expression of connexin 26 (Cx26) in 4.7% of Helix neurons. AMF and carbenoxolone did not induce any significant effect on spontaneous synchronization through electric synapses.

  11. Sarcopenia Is Associated with High Pulse Pressure in Older Women

    Directory of Open Access Journals (Sweden)

    Hélio José Coelho Júnior

    2015-01-01

    Full Text Available Introduction. Sarcopenia is a geriatric syndrome associated with impairment of muscle function, metabolism, and cognition in older women. Recent studies have shown a relationship between changes in muscle mass and the cardiovascular system. However, this relationship has not been fully elucidated. Methods. One hundred and thirty community-dwelling Brazilian older women (65.4 ± 6.3 years were recruited to participate in this study. Data on body composition (via bioelectrical impedance measurements, cardiovascular parameters (using an automatic and noninvasive monitor, and muscle function (using a 3-meter gait speed test were measured. Results. Sarcopenic older women (n=43 presented higher levels of pulse pressure (PP (60.3 ± 2.6 mmHg and lower muscle function (0.5 ± 0.0 m/s compared with nonsarcopenic subjects (n=87 (53.7 ± 1.5 mmHg; 0.9 ± 0.0 m/s (P<0.05. Linear regression analysis demonstrated a significantly negative association between skeletal muscle index (SMI and PP levels (β=−226, P<0.05. Furthermore, sarcopenic older women showed a 3.1-fold increased risk of having higher PP levels compared with nonsarcopenic women (IC = 1.323–7.506 (P<0.05. Conclusion. Sarcopenic older women showed lower muscle function and higher cardiovascular risk due to increased PP levels compared with nonsarcopenic subjects.

  12. Silicon nanowire based biosensing platform for electrochemical sensing of Mebendazole drug activity on breast cancer cells.

    Science.gov (United States)

    Shashaani, Hani; Faramarzpour, Mahsa; Hassanpour, Morteza; Namdar, Nasser; Alikhani, Alireza; Abdolahad, Mohammad

    2016-11-15

    Electrochemical approaches have played crucial roles in bio sensing because of their Potential in achieving sensitive, specific and low-cost detection of biomolecules and other bio evidences. Engineering the electrochemical sensing interface with nanomaterials tends to new generations of label-free biosensors with improved performances in terms of sensitive area and response signals. Here we applied Silicon Nanowire (SiNW) array electrodes (in an integrated architecture of working, counter and reference electrodes) grown by low pressure chemical vapor deposition (LPCVD) system with VLS procedure to electrochemically diagnose the presence of breast cancer cells as well as their response to anticancer drugs. Mebendazole (MBZ), has been used as antitubulin drug. It perturbs the anodic/cathodic response of the cell covered biosensor by releasing Cytochrome C in cytoplasm. Reduction of cytochrome C would change the ionic state of the cells monitored by SiNW biosensor. By applying well direct bioelectrical contacts with cancer cells, SiNWs can detect minor signal transduction and bio recognition events, resulting in precise biosensing. Our device detected the trace of MBZ drugs (with the concentration of 2nM) on electrochemical activity MCF-7 cells. Also, experimented biological analysis such as confocal and Flowcytometry assays confirmed the electrochemical results.

  13. A glucose sensor fabricated by piezoelectric inkjet printing of conducting polymers and bienzymes.

    Science.gov (United States)

    Yun, Yeon Hee; Lee, Byung Kook; Choi, Ji Suk; Kim, Sungwon; Yoo, Bongyoung; Kim, Yong Shin; Park, Kinam; Cho, Yong Woo

    2011-01-01

    Piezoelectric inkjet printing of polymers and proteins holds great promise for fabrication of miniaturized bioelectronic devices, such as biochips and biosensors. In this study, a bienzymatic glucose biosensor prototype based on poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonic acid) (PEDOT-PSS), glucose oxidase (GOD), and horseradish peroxidase (HRP) was fabricated by a piezoelectric inkjet printer. An aqueous bioelectrical ink containing PEDOT-PSS, GOD, and HRP was prepared and printed on an indium-tin-oxide (ITO)-coated poly(ethylene terephthalate) (PET) film. The PEDOT-PSS/GOD/HRP sensor was covered with a cellulose acetate membrane. The use of bienzymatic sensing combined with conducting polymers via piezoelectric inkjet printing showed a synergistic effect resulting in significant amplification of the response signal. The glucose sensor reached steady-state current density within 3 s, indicating a fast response time, and exhibited a linear dose-dependent electrochemical response with high sensitivity. The overall result demonstrates that a glucose sensor with high sensitivity could be readily fabricated by a piezoelectric inkjet printing system.

  14. Ethnic differences in lipid metabolism in two groups of obese South African women.

    Science.gov (United States)

    Punyadeera, C; van der Merwe, M T; Crowther, N J; Toman, M; Schlaphoff, G P; Gray, I P

    2001-05-01

    There is a higher prevalence of ischemic heart disease (IHD) in South African white than black women. The objective of this study was to determine biochemical explanations for this prevalence. The study group contained 15 obese black women (OBW) and 14 obese white women (OWW), all premenopausal, who were examined after an overnight fast. Anthropometric measurements and blood concentrations of glucose, non-esterified fatty acids (NEFAs), catecholamines, plasminogen activator inhibitor-1, C-peptide, proinsulin, lipograms, cortisol, growth hormone, and post-heparin lipoprotein lipase activity were measured during an oral glucose tolerance test (OGTT). Body composition was measured using bioelectrical impedance analysis, and subcutaneous and visceral fat mass were assessed with CT-scans. Visceral fat area was higher in OWW (139.7 +/- 10.7 cm(2)) than in OBW (72.3 +/- 3.9 cm(2)) (P Fasting cortisol (266 +/- 24 vs. 197 +/- 19 nmol/l; P < 0.05) was higher in OWW than in OBW. These data demonstrate that OWW have higher visceral fat mass than OBW, which may lead to a more atherogenic fasting and postprandial lipid profile. The higher cortisol levels of the OWW may promote visceral fat deposition.

  15. Maternal nutritional status in early pregnancy is associated with body water and plasma volume changes in a pregnancy cohort in rural Bangladesh.

    Science.gov (United States)

    Gernand, Alison D; Christian, Parul; Schulze, Kerry J; Shaikh, Saijuddin; Labrique, Alain B; Shamim, Abu Ahmed; West, Keith P

    2012-06-01

    Plasma volume expansion has been associated with fetal growth. Our objective was to examine the associations between maternal nutritional status in early pregnancy and extracellular water (ECW), total body water (TBW), and percentage plasma volume change across pregnancy. In a subsample of 377 pregnant women participating in a cluster-randomized trial of micronutrient supplementation, hemoglobin, hematocrit, and multi-frequency bioelectrical impedance were measured at ~10, 20, and 32 wk of gestation. In early pregnancy, women were short (mean ± SD, 148.9 ± 5.3 cm) and thin (19.5 ± 2.5 kg/m(2)). In mixed-effects multiple regression models, a 1-unit higher BMI at ~10 wk was associated with higher ECW and TBW (0.27 and 0.66 kg per kg/m(2), respectively; P pregnancy BMI was negatively associated with gains in ECW and TBW (-0.06 and -0.14 kg per kg/m(2), respectively; P pregnancy have lower ECW and TBW in early, mid, and late pregnancy and lower late pregnancy plasma volume expansion, potentially increasing risk of fetal growth restriction.

  16. The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women

    Institute of Scientific and Technical Information of China (English)

    XU Qing; YANG Yong Tao; LIU Xiao Jun; LYU Chun Jian; MAO Lun; YU Xiao Ming; LIU Ying Hua; KONG Ai Jing; YANG Xue Yan; LIU Zhao; ZHANG Yong; GAO Zhi Ying; WANG Jin; ZHANG Xin Sheng; XUE Chang Yong; LU Yan Ping; LI Li Ming; WANG Lu; ZHANG Qian; TENG Yue; ZHAO Xia; GE Sheng; JING Hong Jiang

    2016-01-01

    Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus (GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks’ gestation (WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight (BW), and body mass index (BMI) were associated with increased risk of GDM. Fat mass (FM), fat mass percentage (FMP), extracellular water (ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass (FFM), muscular mass (MM), and intracellular water (ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity.

  17. Effects of geomagnetic activity variations on the physiological and psychological state of functionally healthy humans: Some results of Azerbaijani studies

    Science.gov (United States)

    Babayev, Elchin S.; Allahverdiyeva, Aysel A.

    There are collaborative and cross-disciplinary space weather studies in the Azerbaijan National Academy of Sciences conducted with purposes of revealing possible effects of solar, geomagnetic and cosmic ray variability on certain technological, biological and ecological systems. This paper describes some results of the experimental studies of influence of the periodical and aperiodical changes of geomagnetic activity upon human brain, human health and psycho-emotional state. It also covers the conclusions of studies on influence of violent solar events and severe geomagnetic storms of the solar cycle 23 on the mentioned systems in middle-latitude location. It is experimentally established that weak and moderate geomagnetic storms do not cause significant changes in the brain's bioelectrical activity and exert only stimulating influence while severe disturbances of geomagnetic conditions cause negative influence, seriously disintegrate brain's functionality, activate braking processes and amplify the negative emotional background of an individual. It is concluded that geomagnetic disturbances affect mainly emotional and vegetative spheres of human beings while characteristics reflecting personality properties do not undergo significant changes.

  18. Relationship between Soft Drink Consumption and Obesity in 9–11 Years Old Children in a Multi-National Study

    Directory of Open Access Journals (Sweden)

    Peter T. Katzmarzyk

    2016-11-01

    Full Text Available The purpose of this study was to determine the association between regular (sugar containing and diet (artificially sweetened soft drink consumption and obesity in children from 12 countries ranging in levels of economic and human development. The sample included 6162 children aged 9–11 years. Information on soft drink consumption was obtained using a food frequency questionnaire. Percentage body fat (%BF was estimated by bio-electrical impedance analysis, body mass index (BMI z-scores were computed using World Health Organization reference data, and obesity was defined as a BMI > +2 standard deviations (SD. Multi-level models were used to investigate trends in BMI z-scores, %BF and obesity across categories of soft drink consumption. Age, sex, study site, parental education and physical activity were included as covariates. There was a significant linear trend in BMI z-scores across categories of consumption of regular soft drinks in boys (p = 0.049, but not in girls; there were no significant trends in %BF or obesity observed in either boys or girls. There was no significant linear trend across categories of diet soft drink consumption in boys, but there was a graded, positive association in girls for BMI z-score (p = 0.0002 and %BF (p = 0.0001. Further research is required to explore these associations using longitudinal research designs.

  19. Effects of ginkgo biloba extract on an experimental model of epilepsy

    Directory of Open Access Journals (Sweden)

    Pilija Vladimir I.

    2004-01-01

    Full Text Available INTRODUCTION The active ingredients of ginkgo biloba extracts were determined by biochemical analyses in the last ten years and they are widely used in classical medicine. The active substances of ginkgo biloba extract, mostly affect muscarinic receptors and adrenergic receptors to a lesser degree. Recently, potential effects of ginkgo biloba on NMDA receptors and on epileptogenic seizures have been considered. The main goal of this research was to investigate effects of ginkgo biloba extracts on the experimantal model of epilepsy. Material and methODS The research was carried out on chinchilla rabbits. GINGIUM solution was used with 40 mg in 1 ml of dry extract of ginkgo biloba leaves. The epileptogenic area was formed by stimulating hippocampus. Bioelectrical activity was registered 60 minutes before the epileptogenic area was formed as well as 90 minutes later. Ginkgo biloba extract was given via IM, in a single daily dose of 1ml/kg/BW. RESULTS A statistically significantly higher frequency of paroxysmal seizures was established after usage of ginkgo biloba. CONCLUSION According to the results obtained in this research, we can conclude that ginkgo biloba extracts have a proconvulsive activity.

  20. Impact of crystalline quality on neuronal affinity of pristine graphene.

    Science.gov (United States)

    Veliev, Farida; Briançon-Marjollet, Anne; Bouchiat, Vincent; Delacour, Cécile

    2016-04-01

    Due to its outstanding mechanical and electrical properties as well as chemical inertness, graphene has attracted a growing interest in the field of bioelectric interfacing. Herein, we investigate the suitability of pristine, i.e. without a cell adhesive coating, chemical vapor deposition (CVD) grown monolayer graphene to act as a platform for neuronal growth. We study the development of primary hippocampal neurons grown on bare graphene (transferred on glass coverslip) for up to 5 days and show that pristine graphene significantly improves the neurons adhesion and outgrowth at the early stage of culture (1-2 days in vitro). At the later development stage, neurons grown on coating free graphene (untreated with poly-L-lysine) show remarkably well developed neuritic architecture similar to those cultured on conventional poly-L-lysine coated glass coverslips. This exceptional possibility to bypass the adhesive coating allows a direct electrical contact of graphene to the cells and reveals its great potential for chronic medical implants and tissue engineering. Moreover, regarding the controversial results obtained on the neuronal affinity of pristine graphene and its ability to support neuronal growth without the need of polymer or protein coating, we found that the crystallinity of CVD grown graphene plays an important role in neuronal attachment, outgrowth and axonal specification. In particular, we show that the decreasing crystalline quality of graphene tunes the neuronal affinity from highly adhesive to fully repellent.