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Sample records for biodynamics

  1. An overview of the biodynamic wine sector

    Directory of Open Access Journals (Sweden)

    Castellini A

    2017-02-01

    Full Text Available Alessandra Castellini,1 Christine Mauracher,2 Stefania Troiano3 1Department of Agricultural Sciences, Alma Mater Studiorum, University of Bologna, Bologna, 2Department of Management, University Ca’ Foscari of Venice, Venice, 3Department of Economics and Statistics, University of Udine, Udine, Italy Abstract: The wine industry is currently shifting toward more sustainable production practices. Due to the growing globalized wine market and the increasing environmental impacts, producers have begun to pay more attention to organic and biodynamic products. Using a systematic literature review, this review aims to investigate the biodynamic production system in the viticulture and winemaking process. In particular, the review examines, 1 the biodynamic practice and its main characteristics including the certification system; 2 the biodynamic market characteristics and the recent trends, the production costs and the marketing strategies adopted by wineries; 3 the demand attributes and wine consumers’ perception on sustainable practices and “green products” such as biodynamic products; and 4 the association between the biodynamic wine chain and the environment. The review highlights the research progress in this field and reflects on the potentiality and needs of the biodynamic viticulture and wine sector. The literature clearly indicates the lack of knowledge regarding, mainly, the biodynamic farming concept and the label. Moreover, while it is clear that consumers are willing to spend more for an organic wine than for a conventional one, there are no data about the willingness to pay for biodynamic wines. Finally, the review concludes with implications and suggestions for further research. Keywords: biodynamic, viticulture, wine, environment, market analysis, consumer

  2. Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers

    Science.gov (United States)

    2017-01-01

    Conspectus Constitutional dynamic chemistry (CDC) features the use of reversible linkages at both molecular and supramolecular levels, including reversible covalent bonds (dynamic covalent chemistry, DCC) and noncovalent interactions (dynamic noncovalent chemistry, DNCC). Due to its inherent reversibility and stimuli-responsiveness, CDC has been widely utilized as a powerful tool for the screening of bioactive compounds, the exploitation of receptors or substrates driven by molecular recognition, and the fabrication of constitutionally dynamic materials. Implementation of CDC in biopolymer science leads to the generation of constitutionally dynamic analogues of biopolymers, biodynamers, at the molecular level (molecular biodynamers) through DCC or at the supramolecular level (supramolecular biodynamers) via DNCC. Therefore, biodynamers are prepared by reversible covalent polymerization or noncovalent polyassociation of biorelevant monomers. In particular, molecular biodynamers, biodynamers of the covalent type whose monomeric units are connected by reversible covalent bonds, are generated by reversible polymerization of bio-based monomers and can be seen as a combination of biopolymers with DCC. Owing to the reversible covalent bonds used in DCC, molecular biodynamers can undergo continuous and spontaneous constitutional modifications via incorporation/decorporation and exchange of biorelevant monomers in response to internal or external stimuli. As a result, they behave as adaptive materials with novel properties, such as self-healing, stimuli-responsiveness, and tunable mechanical and optical character. More specifically, molecular biodynamers combine the biorelevant characters (e.g., biocompatibility, biodegradability, biofunctionality) of bioactive monomers with the dynamic features of reversible covalent bonds (e.g., changeable, tunable, controllable, self-healing, and stimuli-responsive capacities), to realize synergistic properties in one system. In addition

  3. biodynamics

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    Vladimir Ivancevic

    2005-01-01

    oscillatory, neurodynamical system, resembling the associative interaction of excitatory granule cells and inhibitory Purkinje cells. On the cortical level, a topological “hyper-joystick” command space is formulated with a fuzzy-logic feedback-control map defined on it, resembling the regulation of locomotor conditioned reflexes. Finally, both the cerebellar and the cortical control systems are extended to provide translational force control for moving 6-degree-of-freedom chains of inverse kinematics.

  4. Chemical Biodynamics Division. Annual report 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The Chemical Biodynamics Division of LBL continues to conduct basic research on the dynamics of living cells and on the interaction of radiant energy with organic matter. Many aspects of this basic research are related to problems of environmental and health effects of fossil fuel combustion, solar energy conversion and chemical/ viral carcinogenesis.

  5. An Experimental Test of a Biodynamic Method of Weed Suppression: The Biodynamic Seed Peppers

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    Bruce Kenneth Kirchoff

    2016-04-01

    Full Text Available An experimental test of a biodynamic agriculture method of weed suppression was carried out in growth chambers to establish the feasibility of the method as a preliminary to field trials. Four generations of Brassica rapa plants were used in a randomized block design. Treated flats received ashed seeds prepared according to biodynamic indications. Seed weight and counts were measured at the end of each generation, and germination of the control and experimental seed was investigated at the end of generation four. The biodynamic seed peppers, created and applied as described here, had no effect on seed production or viability, and did not effectively inhibit reproduction of the targeted species over the course of four consecutive treatments.

  6. BIODYNAMIC AGRICULTURE - ECO-FRIENDLY AGRICULTURAL PRACTICE

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    Veselka Vlahova

    2015-06-01

    Full Text Available Biodynamic agriculture is undoubtedly the oldest organized agricultural movement in the world. It is considered as an organic agricultural farming approach and determined as the oldest organized alternative agricultural movement in the world. In 1924 Rudolf Steiner – an Austrian natural scientist and philosopher, carried out a series of eight lectures in Koberwitz, currently Kobierzyce- Poland, where he formulated his visions on changes in agriculture and revealed his spiritual and scientific concepts about the connection between nature and agriculture by determining the important role of agriculture for the future of humanity and thus he became known as “the father of anthroposophy”. The great ecological effect of the application of the biodynamic agriculture is expressed in soil preservation and preservation of the living organisms in the soil, as well as maintenance of the natural balance in the vegetable and animal kingdom.

  7. Biodynamics of deformable human body motion

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    Strauss, A. M.; Huston, R. L.

    1976-01-01

    The objective is to construct a framework wherein the various models of human biomaterials fit in order to describe the biodynamic response of the human body. The behavior of the human body in various situations, from low frequency, low amplitude vibrations to impact loadings in automobile and aircraft crashes, is very complicated with respect to all aspects of the problem: materials, geometry and dynamics. The materials problem is the primary concern, but the materials problem is intimately connected with geometry and dynamics.

  8. Impact of pilots' biodynamic feedthrough on rotorcraft by robust stability

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    Quaranta, Giuseppe; Masarati, Pierangelo; Venrooij, Joost

    2013-09-01

    The coupling of rotorcraft dynamics with the dynamics of one of the main systems devoted to its control, the pilot, may lead to several peculiar phenomena, known as Rotorcraft-Pilot Couplings (RPCs), all characterized by an abnormal behavior that may jeopardize flight safety. Among these phenomena, there is a special class of couplings which is dominated by the biodynamic behavior of the pilot's limbs that close the loop between the vibrations and the control inceptors in the cockpit. Leveraging robust stability analysis, the inherently uncertain pilot biodynamics can be treated as the uncertain portion of a feedback system, making analytical, numerical or graphical determination of proneness to RPC possible by comparing robust stability margins of helicopter models with experimental Biodynamic Feedthrough (BDFT) data. The application of the proposed approach to collective bounce is exemplified using simple analytical helicopter and pilot models. The approach is also applied to detailed helicopter models and experimental BDFT measurement data.

  9. Biodynamic Agriculture: Self-Maintenance on Rural Properties

    OpenAIRE

    Pfitscher, Elisete Dahmer; Universidade Federal de Santa Catarina; Pfitscher, Paulo Cesar; Caixa Econômica Federal - CEF; Soares, Sandro Vieira; Universidade Federal de Santa Catarina

    2010-01-01

    Maintainable development privileges life quality coupled to the environment. A new trend has developed through the implementation of self-maintenance of the small rural properties, or rather, working participatively in productive chains inserted into the performance of agro-poles. Current research, which analyzes the perspectives of bio-dynamic rice culture as an alternative for survival within the context of small farms, has three different phases: first, semi-structured interviews with prof...

  10. Naval Biodynamics Laboratory: 1989 and 1990 Command History

    Science.gov (United States)

    1991-07-01

    Washington, DC Dr. Charles McLeod Maryland Medical Laboratory Baltimore, MD CDR Kenneth Meyer Naval Medical Center Corpus Christi , TX 62 1989 and 1990...Padro, Madrid , Spain, 24-26 April 1990. Call, D. W., "Mission and Capabilities of the Naval Biodynamics Laboratory." Three separate presentations and...Seminar, Baton Rouge, LA, 15 February 1990. Call, D. W., attended the NATO IEG/6 Ship Design SG/5 Seakeeping Conference, Madrid , Spain, 22-28 April

  11. Plant growth promoting bacteria from cow dung based biodynamic preparations.

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    Radha, T K; Rao, D L N

    2014-12-01

    Indigenous formulations based on cow dung fermentation are commonly used in organic farming. Three biodynamic preparations viz., Panchagavya (PG), BD500 and 'Cow pat pit' (CPP) showed high counts of lactobacilli (10(9) ml(-1)) and yeasts (10(4) ml(-1)). Actinomycetes were present only in CPP (10(4) ml(-1)) and absent in the other two. Seven bacterial isolates from these ferments were identified by a polyphasic approach: Bacillus safensis (PG1), Bacillus cereus (PG2, PG4 PG5), Bacillus subtilis (BD2) Lysinibacillus xylanilyticus (BD3) and Bacillus licheniformis (CPP1). This is the first report of L. xylanilyticus and B. licheniformis in biodynamic preparations. Only three carbon sources-dextrose, sucrose and trehalose out of 21 tested were utilized by all the bacteria. None could utilize arabinose, dulcitol, galactose, inositol, inulin, melibiose, raffinose, rhamnose and sorbitol. All the strains produced indole acetic acid (1.8-3.7 μg ml(-1) culture filtrate) and ammonia. None could fix nitrogen; but all except B. safensis and B. licheniformis could solubilize phosphorous from insoluble tri-calcium phosphate. All the strains except L. xylaniliticus exhibited antagonism to the plant pathogen Rhizoctonia bataticola whereas none could inhibit Sclerotium rolfsi. In green house experiment in soil microcosms, bacterial inoculation significantly promoted growth of maize; plant dry weight increased by ~21 % due to inoculation with B. cereus (PG2). Results provide a basis for understanding the beneficial effects of biodynamic preparations and industrial deployment of the strains.

  12. Biodynamic Doppler imaging of subcellular motion inside 3D living tissue culture and biopsies (Conference Presentation)

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    Nolte, David D.

    2016-03-01

    Biodynamic imaging is an emerging 3D optical imaging technology that probes up to 1 mm deep inside three-dimensional living tissue using short-coherence dynamic light scattering to measure the intracellular motions of cells inside their natural microenvironments. Biodynamic imaging is label-free and non-invasive. The information content of biodynamic imaging is captured through tissue dynamics spectroscopy that displays the changes in the Doppler signatures from intracellular constituents in response to applied compounds. The affected dynamic intracellular mechanisms include organelle transport, membrane undulations, cytoskeletal restructuring, strain at cellular adhesions, cytokinesis, mitosis, exo- and endo-cytosis among others. The development of 3D high-content assays such as biodynamic profiling can become a critical new tool for assessing efficacy of drugs and the suitability of specific types of tissue growth for drug discovery and development. The use of biodynamic profiling to predict clinical outcome of living biopsies to cancer therapeutics can be developed into a phenotypic companion diagnostic, as well as a new tool for therapy selection in personalized medicine. This invited talk will present an overview of the optical, physical and physiological processes involved in biodynamic imaging. Several different biodynamic imaging modalities include motility contrast imaging (MCI), tissue-dynamics spectroscopy (TDS) and tissue-dynamics imaging (TDI). A wide range of potential applications will be described that include process monitoring for 3D tissue culture, drug discovery and development, cancer therapy selection, embryo assessment for in-vitro fertilization and artificial reproductive technologies, among others.

  13. Plant Growth Promoting Bacteria from Cow Dung Based Biodynamic Preparations

    OpenAIRE

    Radha, T. K.; RAO, D. L. N.

    2014-01-01

    Indigenous formulations based on cow dung fermentation are commonly used in organic farming. Three biodynamic preparations viz., Panchagavya (PG), BD500 and ‘Cow pat pit’ (CPP) showed high counts of lactobacilli (109 ml−1) and yeasts (104 ml−1). Actinomycetes were present only in CPP (104 ml−1) and absent in the other two. Seven bacterial isolates from these ferments were identified by a polyphasic approach: Bacillus safensis (PG1), Bacillus cereus (PG2, PG4 PG5), Bacillus subtilis (BD2) Lysi...

  14. Growth, Yield and Fruit Quality of Grapevines under Organic and Biodynamic Management.

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    Döring, Johanna; Frisch, Matthias; Tittmann, Susanne; Stoll, Manfred; Kauer, Randolf

    2015-01-01

    The main objective of this study was to determine growth, yield and fruit quality of grapevines under organic and biodynamic management in relation to integrated viticultural practices. Furthermore, the mechanisms for the observed changes in growth, yield and fruit quality were investigated by determining nutrient status, physiological performance of the plants and disease incidence on bunches in three consecutive growing seasons. A field trial (Vitis vinifera L. cv. Riesling) was set up at Hochschule Geisenheim University, Germany. The integrated treatment was managed according to the code of good practice. Organic and biodynamic plots were managed according to Regulation (EC) No 834/2007 and Regulation (EC) No 889/2008 and according to ECOVIN- and Demeter-Standards, respectively. The growth and yield of the grapevines differed strongly among the different management systems, whereas fruit quality was not affected by the management system. The organic and the biodynamic treatments showed significantly lower growth and yield in comparison to the integrated treatment. The physiological performance was significantly lower in the organic and the biodynamic systems, which may account for differences in growth and cluster weight and might therefore induce lower yields of the respective treatments. Soil management and fertilization strategy could be responsible factors for these changes. Yields of the organic and the biodynamic treatments partially decreased due to higher disease incidence of downy mildew. The organic and the biodynamic plant protection strategies that exclude the use of synthetic fungicides are likely to induce higher disease incidence and might partially account for differences in the nutrient status of vines under organic and biodynamic management. Use of the biodynamic preparations had little influence on vine growth and yield. Due to the investigation of important parameters that induce changes especially in growth and yield of grapevines under

  15. Biodynamic profiling of three-dimensional tissue growth techniques

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    Sun, Hao; Merrill, Dan; Turek, John; Nolte, David

    2016-03-01

    Three-dimensional tissue culture presents a more biologically relevant environment in which to perform drug development than conventional two-dimensional cell culture. However, obtaining high-content information from inside three dimensional tissue has presented an obstacle to rapid adoption of 3D tissue culture for pharmaceutical applications. Biodynamic imaging is a high-content three-dimensional optical imaging technology based on low-coherence interferometry and digital holography that uses intracellular dynamics as high-content image contrast. In this paper, we use biodynamic imaging to compare pharmaceutical responses to Taxol of three-dimensional multicellular spheroids grown by three different growth techniques: rotating bioreactor, hanging-drop and plate-grown spheroids. The three growth techniques have systematic variations among tissue cohesiveness and intracellular activity and consequently display different pharmacodynamics under identical drug dose conditions. The in vitro tissue cultures are also compared to ex vivo living biopsies. These results demonstrate that three-dimensional tissue cultures are not equivalent, and that drug-response studies must take into account the growth method.

  16. Differences in the Financial Management of Conventional, Organic, and Biodynamic Farms

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    Vlašicová Eliška

    2015-09-01

    Full Text Available The financial management of conventional, organic, and biodynamic farms was evaluated and compared. It is a highly specific issue filling in the gap namely in the area of economic research of biodynamic agriculture. Biodynamic agriculture is a less widespread concept of agriculture, the management of which meets the requirements of organic agriculture. Organic agriculture has still been gaining in importance in the Czech Republic, the number of organic farms has been growing, and availability of organic products has increased, too. Of the Czech farms receiving subsidies from the EU or state subsidies in 2007-2012, a total of 389 were selected for analysis (273 of which were conventional farms, 112 organic farms, and 4 farms were engaged in biodynamic agriculture. Subsidies, Total Costs, Operating Revenue, Profit and Gross Value Added indicators were selected for evaluation. The individual indicators within groups of companies were compared by means of a t-test. The analysis revealed significant differences in the economic indicators of individual types of farms. It was observed that organic enterprises have better economic results than conventional and biodynamic businesses. Subsidies help all types of farms achieve better results. We may hence assume dependence of these farms on subsidies.

  17. Identification of organic and biodynamic grape and wine producers in southern Brazil

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    Medeiros Narjara

    2014-01-01

    Full Text Available The concern about health and environmental aspects are increasingly present in our society. In 1976 José Lutzemberger publishes the first Brazilian ecological manifesto. In 2003 the Law 10.831 is approved, which conceptualizes and defines organic agriculture. In 1982, the first Biodynamic Agriculture meeting in Brazil happens, where the construction of the basis for the implementation of biodynamic in Brazilian agriculture started. In 1995 the Brazilian Association of Biodynamic Agriculture is created. The search for organic products – that doesn't use artificial mineral and chemical fertilizers and exploits fertility as a way of fighting diseases and pests – and biodynamic products in the agricultural production unit is understood as a kind of organism also take place in the wine industry. But knowing which producers are involved in this type of activity is still a difficult task for the community, especially due to the informality of some agents. Thus, this paper proposes to identify organic and biodynamic wine producers in southern Brazil; as well as the tools and policies which have encouraged farmers to adopt these practices. Finally, understanding the main obstacles producers find dealing with certifications mechanisms. This region was chosen for being the largest grape and wine producing in the country.

  18. Ernst Haeckel's biodynamics 1866 and the occult basis of organic farming.

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    Kutschera, Ulrich

    2016-07-02

    One hundred and 50 years ago (Sept. 1866), Ernst Haeckel published a monograph entitled General Morphology of Organisms, wherein key terms, such as Protista, Monera, ontogeny, phylogeny, ecology and the 'biogenetic law' where introduced. In addition, Haeckel coined the word "biodynamics" as a synonym for "general physiology." In contrast, Rudolf Steiner's "biodynamic agriculture," which originated in 1924, and was promoted via Ehrenfried Pfeiffer's book of 1938 with the same title, is an occult pseudoscience still popular today. The misuse of Haeckel's term to legitimize disproven homeopathic principles and esoteric rules within the context of applied plant research is unacceptable.

  19. Application of biodynamic imaging for personalized chemotherapy in canine lymphoma

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    Custead, Michelle R.

    Biodynamic imaging (BDI) is a novel phenotypic cancer profiling technology which characterizes changes in cellular and subcellular motion in living tumor tissue samples following in vitro or ex vivo treatment with chemotherapeutics. The ability of BDI to predict clinical response to single-agent doxorubicin chemotherapy was tested in ten dogs with naturally-occurring non-Hodgkin's lymphomas (NHL). Pre-treatment tumor biopsy samples were obtained from all dogs and treated with doxorubicin (10 muM) ex vivo. BDI captured cellular and subcellular motility measures on all biopsy samples at baseline and at regular intervals for 9 hours following drug application. All dogs subsequently received treatment with a standard single-agent doxorubicin protocol. Objective response (OR) to doxorubicin and progression-free survival time (PFST) following chemotherapy were recorded for all dogs. The dynamic biomarkers measured by BDI were entered into a multivariate logistic model to determine the extent to which BDI predicted OR and PFST following doxorubicin therapy. The model showed that the sensitivity, specificity, and accuracy of BDI for predicting treatment outcome were 95%, 91%, and 93%, respectively. To account for possible over-fitting of data to the predictive model, cross-validation with a one-left-out analysis was performed, and the adjusted sensitivity, specificity, and accuracy following this analysis were 93%, 87%, and 91%, respectively. These findings suggest that BDI can predict, with high accuracy, treatment outcome following single-agent doxorubicin chemotherapy in a relevant spontaneous canine cancer model, and is a promising novel technology for advancing personalized cancer medicine.

  20. Biodynamic modelling and the prediction of accumulated trace metal concentrations in the polychaete Arenicola marina

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    Casado-Martinez, M. Carmen, E-mail: c.casado-martinez@nhm.ac.u [Department of Zoology, The Natural History Museum, Cromwell Rd, London SW7 5BD (United Kingdom); Smith, Brian D. [Department of Zoology, The Natural History Museum, Cromwell Rd, London SW7 5BD (United Kingdom); DelValls, T. Angel [Unesco UNITWIN Wicop Chair, Department of Physical-Chemistry, University of Cadiz, Poligono Industrial Rio San Pedro s/n, C.P. 11510 Puerto Real (Cadiz) (Spain); Luoma, Samuel N. [John Muir Institute of the Environment, University of California at Davis, Davis, CA 95616 (United States); Rainbow, Philip S. [Department of Zoology, The Natural History Museum, Cromwell Rd, London SW7 5BD (United Kingdom)

    2009-10-15

    The use of biodynamic models to understand metal uptake directly from sediments by deposit-feeding organisms still represents a special challenge. In this study, accumulated concentrations of Cd, Zn and Ag predicted by biodynamic modelling in the lugworm Arenicola marina have been compared to measured concentrations in field populations in several UK estuaries. The biodynamic model predicted accumulated field Cd concentrations remarkably accurately, and predicted bioaccumulated Ag concentrations were in the range of those measured in lugworms collected from the field. For Zn the model showed less but still good comparability, accurately predicting Zn bioaccumulation in A. marina at high sediment concentrations but underestimating accumulated Zn in the worms from sites with low and intermediate levels of Zn sediment contamination. Therefore, it appears that the physiological parameters experimentally derived for A. marina are applicable to the conditions encountered in these environments and that the assumptions made in the model are plausible. - Biodynamic modelling predicts accumulated field concentrations of Ag, Cd and Zn in the deposit-feeding polychaete Arenicola marina.

  1. Soil response to biodynamic farming practices in estevia -Stevia Rebaudiana- (Extremadura, Spain)

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    Labrador, Juana; Colmenares, Ricardo; Sánchez, Eduardo; Creus, Juan; García, Nieves; Blázquez, Jaime; Moreno, Marta M.

    2014-05-01

    The first results of the evolution of an organic-biodynamic cultivation of stevia (Stevia rebaudiana) in Extremadura (Spain) are shown here. The organic-biodynamic approach permits experimentally for a more holistic view of the crop development process what means the understanding and quantification of its evolution at different scales. The research methodology applied includes not only quantitative individual parameters of the crop development but also global parameters which make a contribution of very relevant information concerning unbalances between growth and differentiation processes, as well as other aspects linked to the product intrinsic quality. The crop cultivation has been done over a plot of 2.5 has, on acid soils (pH 5.18) and very poor organic matter content (0.5 %). On this first year of cultivation two cuts were given to the plant with an average total yield of 4,500 kg/ha without any supply of solid organic matter, only with the application of the biodynamic preparations. So far results regarding soil improvement and crop productivity, taking into consideration the practices used, let us introduce this pioneer crop in Extremadura, not only as an alternative crop to the current tobacco crop in this area, but also as a development resource for the rural environment of this region. Key words: Agroecology, Organic Biodynamic Agriculture, Stevia Rebaudiana

  2. Expectation or Sensorial Reality? An Empirical Investigation of the Biodynamic Calendar for Wine Drinkers.

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    Parr, Wendy V; Valentin, Dominique; Reedman, Phil; Grose, Claire; Green, James A

    2017-01-01

    The study's aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors. Wine descriptors spanned a range of varietal-relevant aroma, taste, and mouthfeel characteristics, and were selected with the aim of elucidating both qualitative and quantitative aspects of each wine's perceived aromatic, taste, and structural aspects including overall wine quality and liking. A post-experimental questionnaire was completed by each participant to determine their degree of knowledge about the purpose of the study, and their awareness of the existence of the biodynamic wine drinkers' calendar. Basic wine physico-chemical parameters were determined for the wines tasted on each of a Fruit day and a Root day. Results demonstrated that the wines were judged differentially on all attributes measured although type of day as determined by the biodynamic calendar for wine drinkers did not influence systematically any of the wine characteristics evaluated. The findings highlight the importance of testing experimentally practices that are based on anecdotal evidence but that lend themselves to empirical investigation.

  3. SU-E-J-31: Biodynamic Imaging of Cancer Tissue and Response to Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Nolte, D; Turek, J; Childress, M; An, R; Merrill, D [Purdue University, West Lafayette, IN (United States); Matei, D [Indiana University School of Medicine, Indianapolis, IN (United States)

    2014-06-01

    Purpose: To measure intracellular motions inside three-dimensional living cancer tissue samples to establish a novel set of biodynamic biomarkers that assess tissue proliferative activity and sensitivity or resistance to chemotherapy. Methods: Biodynamic imaging (BDI) uses digital holography with low-coherence low-intensity light illumination to construct 3D holograms from depths up to a millimeter deep inside cancer tissue models that include multicellular tumor spheroids and ex vivo cancer biopsies from canine non-Hodgkins lymphoma and epithelial ovarian cancer (EOC) mouse explants. Intracellular motions modulate the holographic intensity with frequencies related to the Doppler effect caused by the motions of a wide variety of intracellular components. These motions are affected by applied therapeutic agents, and BDI produces unique fingerprints of the action of specific drugs on the motions in specific cell types. In this study, chemotherapeutic agents (doxorubicin for canine lymphoma and oxoplatin for ovarian) are applied to the living tissue models and monitored over 10 hours by BDI. Results: Multicellular spheroids and patient biopsies are categorized as either sensitive or insensitive to applied therapeutics depending on the intracellular Doppler signatures of chemotherapy response. For both lymphoma and EOC there is strong specificity to the two types of sensitivities, with sensitive cell lines and biopsies exhibiting a global cessation of proliferation and strong suppression of metabolic activity, while insensitive cell lines and biopsies show moderate activation of Doppler frequencies associated with membrane processes and possible membrane trafficking. Conclusion: This work supports the hypothesis that biodynamic biomarkers from three-dimensional living tumor tissue, that includes tissue heterogeneity and measured within 24 hours of surgery, is predictive of near-term patient response to therapy. Future work will correlate biodynamic biomarkers with

  4. A framework for biodynamic feedthrough analysis--part I: theoretical foundations.

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    Venrooij, Joost; van Paassen, Marinus M; Mulder, Mark; Abbink, David A; Mulder, Max; van der Helm, Frans C T; Bulthoff, Heinrich H

    2014-09-01

    Biodynamic feedthrough (BDFT) is a complex phenomenon, which has been studied for several decades. However, there is little consensus on how to approach the BDFT problem in terms of definitions, nomenclature, and mathematical descriptions. In this paper, a framework for biodynamic feedthrough analysis is presented. The goal of this framework is two-fold. First, it provides some common ground between the seemingly large range of different approaches existing in the BDFT literature. Second, the framework itself allows for gaining new insights into BDFT phenomena. It will be shown how relevant signals can be obtained from measurement, how different BDFT dynamics can be derived from them, and how these different dynamics are related. Using the framework, BDFT can be dissected into several dynamical relationships, each relevant in understanding BDFT phenomena in more detail. The presentation of the BDFT framework is divided into two parts. This paper, Part I, addresses the theoretical foundations of the framework. Part II, which is also published in this issue, addresses the validation of the framework. The work is presented in two separate papers to allow for a detailed discussion of both the framework's theoretical background and its validation.

  5. Limiting Performance Analysis of Underwater Shock Isolation of a System with Biodynamic Response Using Genetic Algorithm

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    Z. Zong

    2000-01-01

    Full Text Available Biodynamic response of shipboard crew to underwater shock is of a major concern to navies. An underwater shock can produce very high accelerations, resulting in severe human injuries aboard a battleship. Protection of human bodies from underwater shock is implemented by installing onboard isolators. In this paper, the optimal underwater shock isolation to protect human bodies is studied. A simple shock-structure-isolator-human interaction model is first constructed. The model incorporates the effect of fluid-structure interaction, biodynamic response of human body, isolator influence. Based on this model, the optimum shock isolation is then formulated. The performance index and restriction are defined. Thirdly, GA (genetic algorithm is employed to solve the formulated optimization problem. GA is a powerful evolutionary optimization scheme suitable for large-scale and multi-variable optimization problems that are otherwise hard to be solved by conventional methods. A brief introduction to GA is given in the paper. Finally, the method is applied to an example problem and the limiting performance characteristic is obtained.

  6. Comparative Biodynamics; The Form and Function of Two Living Stromatolite Assemblages.

    Science.gov (United States)

    Paterson, D. M.; Gleeson, D.; Burns, B.; Collins, L.

    2014-12-01

    Life arose very rapidly on the surface of the Earth after the conditions on the early planet stabilized. The first visible record of life is now represented by the fossilized signature of microbial communities on the surface of ancient sediments. Even at this early stage, at the onset of ecology, it is clear that the development of biofilms at the sediment-water interface would have affected the response of the surface to erosive force. The close interaction between biology and physical dynamics started early. The stabilization of the sediment will have been important in promoting the development of biogeochemical gradients, and promoting the niche segregation that drives evolution. As these microbial mat systems evolved is likely that their binding capacity changed as form and function developed. The onset of photosynthesis was a step change in this process. Studies on the biodynamics of modern Bahamian stromatolites demonstrated the importance of photosynthesis in promoting the biogenic stabilization of the carbonate (ooid) sediments by microbial assemblages derived from living stromatolites. The present study presents a comparative assessment of this work using new material from living stromatolitic assemblages from Shark Bay, Australia. Samples of stromatolites were taken and the natural microbial assemblages extracted and characterized. Microbial assemblages were incubated on the surface of clean sediment and the relative stabilization of the surface measured using the cohesive strength meter system to determine surface stability against time. Magnetic particle induction was also used to determine the relative adhesive capacity of the surfaces as assemblages developed. The results are presented and examined in contrast to the previous work on the biodynamics of modern Bahamian stromatolitic systems showing significant variation in form and function between the two different stromatolitic assemblages. The reasons for this variation are discussed.

  7. Experimentally fitted biodynamic models for pedestrian-structure interaction in walking situations

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    Toso, Marcelo André; Gomes, Herbert Martins; da Silva, Felipe Tavares; Pimentel, Roberto Leal

    2016-05-01

    The interaction between moving humans and structures usually occurs in slender structures in which the level of vibration is potentially high. Furthermore, there is the addition of mass to the structural system due to the presence of people and an increase in damping due to the human body´s ability to absorb vibrational energy. In this paper, a test campaign is presented to obtain parameters for a single degree of freedom (SDOF) biodynamic model that represents the action of a walking pedestrian in the vertical direction. The parameters of this model are the mass (m), damping (c) and stiffness (k). The measurements were performed on a force platform, and the inputs were the spectral acceleration amplitudes of the first three harmonics at the waist level of the test subjects and the corresponding amplitudes of the first three harmonics of the vertical ground reaction force. This leads to a system of nonlinear equations that is solved using a gradient-based optimization algorithm. A set of individuals took part in the tests to ensure inter-subject variability, and, regression expressions and an artificial neural network (ANN) were used to relate the biodynamic parameters to the pacing rate and the body mass of the pedestrians. The results showed some scatter in damping and stiffness that could not be precisely correlated with the masses and pacing rates of the subjects. The use of the ANN resulted in significant improvements in the parameter expressions with a low uncertainty. Finally, the measured vertical accelerations on a prototype footbridge show the adequacy of the numerical model for the representation of the effects of walking pedestrians on a structure. The results are consistent for many crowd densities.

  8. Biodynamics circulation

    CERN Document Server

    Fung, Y C

    1984-01-01

    This book is a continuation of my Biomechanics.The first volume deals with the mechanical properties of living tissues. The present volume deals with the mechanics ofcirculation. A third volume willdeal with respiration, fluid balance, locomotion, growth, and strength. This volume is called Bio­ dynamics in order to distinguish it from the first volume. The same style is followed. My objective is to present the mechanical aspects ofphysiology in precise terms ofmechanics so that the subject can become as lucid as physics. The motivation of writing this series of books is, as I have said in the preface to the first volume, to bring biomechanics to students ofbioengineer­ ing, physiology, medicine, and mechanics. I have long felt a need for a set of books that willinform the students ofthe physiological and medical applica­ tions ofbiomechanics,and at the same time develop their training in mechan­ ics. In writing these books I have assumed that the reader already has some basic training in mechanics, to a ...

  9. Chemical Biodynamics Division: Annual report, October 1, 1985-September 30, 1986

    Energy Technology Data Exchange (ETDEWEB)

    1986-10-01

    The research in the Laboratory of Chemical Biodynamics is almost entirely fundamental research. The biological research component is strongly dominated by a long term interest in two main themes which make up our Structural Biology Program. The first interest has to do with understanding the molecular dynamics of photosynthesis. The Laboratory's investigators are studying the various components that make up the photosynthetic reaction center complexes in many different organisms. This work not only involves understanding the kinetics of energy transfer and storage in plants, but also includes studies to work out how photosynthetic cells regulate the expression of genes encoding the photosynthetic apparatus. The second biological theme is a series of investigations into the relationship between structure and function in nucleic acids. Our basic mission in this program is to couple our chemical and biophysical expertise to understand how not only the primary structure of nucleic acids, but also higher levels of structure including interactions with proteins and other nucleic acids regulate the functional activity of genes. In the chemical sciences work in the Laboratory, our investigators are increasing our understanding of the fundamental chemistry of electronically excited molecules, a critical dimension of every photosynthetic energy storage process. We are developing approaches not only toward the utilization of sophisticated chemistry to store photon energy, but also to develop systems that can emulate the photosynthetic apparatus in the trapping and transfer of photosynthetic energy.

  10. 4-DOF biodynamic lumped-parameter models for a seated occupant

    Science.gov (United States)

    Cheng, Wei; Xu, Shi-Xu; Qian, Li-Jun; Bai, Xian-Xu

    2016-04-01

    In order to study how vibrations from ground vehicles/aircraft will impact on the seated occupants, it is of significance to develop an effective biodynamic model for the seated occupants. In this paper, a wide variety of 4-degree-of-freedom (4- DOF) lumped-parameter models for a seated occupant is investigated. A linear 4-DOF model with 18 parameters is deduced and employed as an example. The parameters of the 4-DOF model are identified based on the Pareto optimization principle. The goodness of fit (ɛ) is established and employed to evaluate the effectiveness of the models. Then, all possible linear 4-DOF models are analyzed and discussed with the same parameters identification and effectiveness evaluation. The most-effective two models are obtained and compared with two other existing models. The research results show that: (i) The total types of linear 4-DOF models is limited and all the parameters of models are identifiable; (ii) The number of parameters of the 4-DOF models affects little on the goodness of fit (ɛ); and (iii) The presented models are more effective than the two existing models.

  11. Microbiological features and bioactivity of a fermented manure product (preparation 500) used in biodynamic agriculture.

    Science.gov (United States)

    Giannattasio, Matteo; Vendramin, Elena; Fornasier, Flavio; Alberghini, Sara; Zanardo, Marina; Stellin, Fabio; Concheri, Giuseppe; Stevanato, Piergiorgio; Ertani, Andrea; Nardi, Serenella; Rizzi, Valeria; Piffanelli, Pietro; Spaccini, Riccardo; Mazzei, Pierluigi; Piccolo, Alessandro; Squartini, Andrea

    2013-05-01

    The fermented manure derivative known as Preparation 500 is traditionally used as a field spray in biodynamic agriculture for maintaining and increasing soil fertility. This work aimed at characterizing the product from a microbiological standpoint and at assaying its bioactive properties. The approach involved molecular taxonomical characterization of the culturable microbial community; ARISA fingerprints of the total bacteria and fungal communities; chemical elemental macronutrient analysis via a combustion analyzer; activity assays for six key enzymes; bioassays for bacterial quorum sensing and chitolipooligosaccharide production; and plant hormonelike activity. The material was found to harbor a bacterial community of 2.38 × 10(8) CFU/g dw dominated by Grampositives with minor instances of Actinobacteria and Gammaproteobacteria. ARISA showed a coherence of bacterial assemblages in different preparation lots of the same year in spite of geographic origin. Enzymatic activities showed elevated values of beta-glucosidase, alkaline phosphatase, chitinase, and esterase. The preparation had no quorum sensing-detectable signal, and no rhizobial nod gene-inducing properties, but displayed a strong auxin-like effect on plants. Enzymatic analyses indicated a bioactive potential in the fertility and nutrient cycling contexts. The IAA activity and microbial degradation products qualify for a possible activity as soil biostimulants. Quantitative details and possible modes of action are discussed.

  12. Bioaccumulation of arsenic and silver by the caddisfly larvae Hydropsyche siltalai and H. pellucidula: A biodynamic modeling approach

    Energy Technology Data Exchange (ETDEWEB)

    Awrahman, Zmnako A., E-mail: zmnako.awrahman@uj.edu.pl [Institute of Environmental Science, Jagiellonian University, Krakow 30-348 (Poland); Rainbow, Philip S.; Smith, Brian D. [Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Khan, Farhan R. [Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Department of Environmental, Social and Spatial Change (ENSPAC), Roskilde University, Universitetsvej 1, PO Box 260, Roskilde DK-4000 (Denmark); Bury, Nicolas R. [Nutritional Sciences Division, King’s College London, Franklin–Wilkins Building, 150 Stamford Street, London SE1 9NH (United Kingdom); Fialkowski, Wojciech [Institute of Environmental Science, Jagiellonian University, Krakow 30-348 (Poland)

    2015-04-15

    Highlights: • Biodynamic models were used to predict steady state As and Ag concentrations. • Uptake and efflux rate constants for As and Ag were measured in caddisfly species. • Dietborne As was the predominant exposure route in two caddisfly species. • Diet was the only exposure route of bioaccumulated Ag in the investigated caddisflies. - Abstract: Biodynamic modeling was used to investigate the uptake and bioaccumulation of arsenic and silver from water and food by two Hydropsychid caddisfly larvae: Hydropsyche siltalai and Hydropsyche pellucidula. Radiotracer techniques determined the uptake rate constants of arsenic and silver from water, and assimilation efficiencies from food, and their subsequent loss rate constants after accumulation from either route. The uptake rate constants (±SE) of As and Ag from solution were 0.021 ± 0.005 and 0.350 ± 0.049 L g{sup −1} day{sup −1}, respectively, for H. siltalai, and 0.435 ± 0.054 and 0.277 ± 0.021 L g{sup −1} day{sup −1}, respectively, for H. pellucidula in moderately hard synthetic water at 10 °C. The assimilation efficiencies (±SE) of As and Ag from radiolabeled ingested food were 46.0 ± 7.7% and 75.7 ± 3.6%, respectively, for H. siltalai, and 61.0 ± 4.2% and 52.6 ± 8.6%, respectively, for H. pellucidula. Ag, but not As, AEs were significantly different between species. The AE of Ag differed from the AE of As in H. siltalai, but not in H. pellucidula. Mean efflux rate constants after accumulation of metals from solution or food ranged from 0.039 to 0.190 day{sup −1}. The efflux rate constants of As and Ag accumulated from solution were significantly lower than those of As and Ag assimilated from ingested food in both species. Experimentally derived k{sub u} and k{sub e} values were then used to predict As and Ag tissue concentrations in hydropsychids collected from 13 UK sites, including metal-contaminated streams in Cornwall. Arsenic and silver concentrations in environmental water

  13. Influence of Biodynamic Preparations on the Quality Indices and Antioxidant Compounds Content in the Tubers of Coloured Potatoes (Solanum tuberosum L.

    Directory of Open Access Journals (Sweden)

    Elvyra JARIENĖ

    2015-12-01

    Full Text Available Biodynamic preparations 500 and 501 are plant strengthening agents of biodynamic agriculture method, prepared of manure and powdered quartz. The objective of the present study was to determine effects of biodynamic (BD preparations 500 and 501 on the quality indices and antioxidant compounds content in the tubers of coloured flesh potatoes. The experiment included two factors: potato cultivar and treatment with BD preparations as field sprays. The experiment was carried out in four replications, in a randomly design. Results showed that application of BD preparations did not influence significantly the contents of dry matter, crude fibre and crude ash in all tested cultivars. Separately used BD preparation 500 increased content of total anthocyanins in tubers of ‘Vitelotte’ and ‘Red Emmalie’ and leucoanthocyanins content in ‘Blue Congo’, but decreased the content of total phenolics in all cultivars. Treatment with BD preparation 501 had significant effect on the contents of total phenolics and total anthocyanins in all cultivars. However, treatment with BD preparation 500 in combination with BD preparation 501 substantially increased the contents of total phenolics and total anthocyanins in all cultivars. Tubers of ‘Vitelotte’ with dark-purple flesh contained significantly more antioxidant compounds than the light-purple and red.

  14. The Secrets of Koberwitz: The Diffusion of Rudolf Steiner’s Agriculture Course and the Founding of Biodynamic Agriculture

    Directory of Open Access Journals (Sweden)

    John Paull

    2011-07-01

    Full Text Available Rudolf Steiner presented his Agriculture Course to a group of 111, farmers and others, at Koberwitz (Kobierzyce, Poland in 1924. Steiner spoke of an agriculture to ‘heal the earth’ and he laid the philosophical and practical underpinnings for such a differentiated agriculture. Biodynamic agriculture is now practiced internationally as a specialist form of organic agriculture. The path from proposal to experimentation, to formalization, to implementation and promulgation played out over a decade and a half following the Course and in the absence of its progenitor. Archival material pertaining to the dissemination of the early printed editions of ‘The Agriculture Course’ reveals that within six years of the Course there was a team of more than 400 individuals of the Agricultural Experimental Circle (AEC, each signed a confidentiality agreement, and located throughout continental Europe, and also in Australia, Britain, Canada, New Zealand, South Africa, and USA. Membership expanded to over 1000 AEC members (with a lower bound estimate of 1144 members who were committed to working collectively towards an evidence based, new and alternative agriculture, ‘for all farmers’, which was to be developed into a ‘suitable for publication’ form. That publication milestone was realized in 1938 with the release of Ehrenfried Pfeiffer’s ‘Bio-Dynamic Farming and Gardening’ which was published simultaneously in at least five languages: Dutch, English, French, German and Italian

  15. Are Epiphytic Microbial Communities in the Carposphere of Ripening Grape Clusters (Vitis vinifera L.) Different between Conventional, Organic, and Biodynamic Grapes?

    Science.gov (United States)

    Kecskeméti, Elizabeth; Berkelmann-Löhnertz, Beate; Reineke, Annette

    2016-01-01

    Using barcoded pyrosequencing fungal and bacterial communities associated with grape berry clusters (Vitis vinifera L.) obtained from conventional, organic and biodynamic vineyard plots were investigated in two subsequent years at different stages during berry ripening. The four most abundant operational taxonomic units (OTUs) based on fungal ITS data were Botrytis cinerea, Cladosporium spp., Aureobasidium pullulans and Alternaria alternata which represented 57% and 47% of the total reads in 2010 and 2011, respectively. Members of the genera Sphingomonas, Gluconobacter, Pseudomonas, Erwinia, and Massilia constituted 67% of the total number of bacterial 16S DNA reads in 2010 samples and 78% in 2011 samples. Viticultural management system had no significant effect on abundance of fungi or bacteria in both years and at all three sampling dates. Exceptions were A. alternata and Pseudomonas spp. which were more abundant in the carposphere of conventional compared to biodynamic berries, as well as Sphingomonas spp. which was significantly less abundant on conventional compared to organic berries at an early ripening stage in 2011. In general, there were no significant differences in fungal and bacterial diversity indices or richness evident between management systems. No distinct fungal or bacterial communities were associated with the different maturation stages or management systems, respectively. An exception was the last stage of berry maturation in 2011, where the Simpson diversity index was significantly higher for fungal communities on biodynamic compared to conventional grapes. Our study highlights the existence of complex and dynamic microbial communities in the grape cluster carposphere including both phytopathogenic and potentially antagonistic microorganisms that can have a significant impact on grape production. Such knowledge is particularly relevant for development, selection and application of effective control measures against economically important

  16. Biodynamic modelling of the bioaccumulation of trace metals (Ag, As and Zn) by an infaunal estuarine invertebrate, the clam Scrobicularia plana

    Energy Technology Data Exchange (ETDEWEB)

    Kalman, J., E-mail: judit.kalman@uca.es [Department of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Smith, B.D. [Department of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Bury, N.R. [Division of Diabetes and Nutritional Science, King' s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH (United Kingdom); Rainbow, P.S. [Department of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom)

    2014-09-15

    Highlights: • Biodynamic modelling is used to predict accumulation of Ag, As and Zn in S. plana. • Dissolved and sediment-associated metals contribute to total metal bioaccumulation. • Relative importance varies with water and sediment concentrations and geochemistries. - Abstract: Biodynamic modelling was used to investigate the uptake and accumulation of three trace metals (Ag, As, Zn) by the deposit feeding estuarine bivalve mollusc Scrobicularia plana. Radioactive labelling techniques were used to quantify the rates of trace metal uptake (and subsequent elimination) from water and sediment diet. The uptake rate constant from solution (±SE) was greatest for Ag (3.954 ± 0.375 l g{sup −1} d{sup −1}) followed by As (0.807 ± 0.129 l g{sup −1} d{sup −1}) and Zn (0.103 ± 0.016 l g{sup −1} d{sup −1}). Assimilation efficiencies from ingested sediment were 40.2 ± 1.3% (Ag), 31.7 ± 1.0% (Zn) and 25.3 ± 0.9% (As). Efflux rate constants after exposure to metals in the solution or sediment fell in the range of 0.014–0.060 d{sup −1}. By incorporating these physiological parameters into biodynamic models, our results showed that dissolved metal is the predominant source of accumulated Ag, As and Zn in S. plana, accounting for 66–99%, 50–97% and 52–98% of total accumulation of Ag, As and Zn, respectively, under different field exposure conditions. In general, model-predicted steady state concentrations of Ag, As and Zn matched well with those observed in clams collected in SW England estuaries. Our findings highlight the potential of biodynamic modelling to predict Ag, As and Zn accumulation in S. plana, taking into account specific dissolved and sediment concentrations of the metals at a particular field site, together with local water and sediment geochemistries.

  17. Biodynamic modeling of PCB uptake by Macoma balthica and Corbicula fluminea from sediment amended with activated carbon

    Science.gov (United States)

    McLeod, Pamela B.; Luoma, S.N.; Luthy, R.G.

    2008-01-01

    Activated carbon amendment was assessed in the laboratory as a remediation strategy for freshwater sediment contaminated with polychlorinated biphenyls (PCBs) from the Grasse River (near Massena, NY). Three end points were evaluated: aqueous equilibrium PCB concentration, uptake into semipermeable membrane devices (SPMDs), and 28-day bioaccumulation in the clam Corbicula fluminea. PCB uptake by water, SPMDs, and clams followed similar trends, with reductions increasing as a function of carbon dose. Average percent reductions in clam tissue PCBs were 67, 86, and 95% for activated carbon doses of 0.7, 1.3, and 2.5% dry wt, respectively. A biodynamic model that incorporates sediment geochemistry and dietary and aqueous uptake routes was found to agree well with observed uptake by C. fluminea in our laboratory test systems. Results from this study were compared to 28-day bioaccumulation experiments involving PCB-contaminated sediment from Hunters Point Naval Shipyard (San Francisco Bay, CA) and the clam Macoma balthica. Due to differences in feeding strategy, M. balthica deposit-feeds whereas C. fluminea filter-feeds, the relative importance of the aqueous uptake route is predicted to be much higher for C. fluminea than for M. balthica. Whereas M. balthica takes up approximately 90% of its body burden through sediment ingestion, C. fluminea only accumulates approximately 45% via this route. In both cases, results strongly suggest that it is the mass transfer of PCBs from native sediment to added carbon particles, not merely reductions in aqueous PCB concentrations, that effectively reduces PCB bioavailability and uptake by sediment-dwelling organisms. ?? 2008 American Chemical Society.

  18. In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.

    Science.gov (United States)

    Paini, Alicia; Punt, Ans; Scholz, Gabriele; Gremaud, Eric; Spenkelink, Bert; Alink, Gerrit; Schilter, Benoît; van Bladeren, Peter J; Rietjens, Ivonne M C M

    2012-11-01

    Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure to estragole via the regular diet. The objective of this study was to quantify the dose-dependent estragole-DNA adduct formation in rat liver and the urinary excretion of 1'-hydroxyestragole glucuronide in order to validate our recently developed physiologically based biodynamic (PBBD) model. Groups of male outbred Sprague Dawley rats (n = 10, per group) were administered estragole once by oral gavage at dose levels of 0 (vehicle control), 5, 30, 75, 150, and 300mg estragole/kg bw and sacrificed after 48h. Liver, kidney and lungs were analysed for DNA adducts by LC-MS/MS. Results obtained revealed a dose-dependent increase in DNA adduct formation in the liver. In lungs and kidneys DNA adducts were detected at lower levels than in the liver confirming the occurrence of DNA adducts preferably in the target organ, the liver. The results obtained showed that the PBBD model predictions for both urinary excretion of 1'-hydroxyestragole glucuronide and the guanosine adduct formation in the liver were comparable within less than an order of magnitude to the values actually observed in vivo. The PBBD model was refined using liver zonation to investigate whether its predictive potential could be further improved. The results obtained provide the first data set available on estragole-DNA adduct formation in rats and confirm their occurrence in metabolically active tissues, i.e. liver, lung and kidney, while the significantly higher levels found in liver are in accordance with the liver as the target organ for carcinogenicity. This opens the way towards future modelling of dose-dependent estragole liver DNA adduct formation in human.

  19. Analyses of biodynamic responses of seated occupants to uncorrelated fore-aft and vertical whole-body vibration

    Science.gov (United States)

    Mandapuram, Santosh; Rakheja, Subhash; Marcotte, Pierre; Boileau, Paul-Émile

    2011-08-01

    The apparent mass and seat-to-head-transmissibility response functions of the seated human body were investigated under exposures to fore-aft ( x), vertical ( z), and combined fore-aft and vertical ( x and z) axis whole-body vibration. The coupling effects of dual-axis vibration were investigated using two different frequency response function estimators based upon the cross- and auto-spectral densities of the response and excitation signals, denoted as H1 and Hv estimators, respectively. The experiments were performed to measure the biodynamic responses to single and uncorrelated dual-axis vibration, and to study the effects of hands support, back support and vibration magnitude on the body interactions with the seatpan and the backrest, characterized in terms of apparent masses and the vibration transmitted to the head. The data were acquired with 9 subjects exposed to two different magnitudes of vibration applied along the individual x- and z-axis (0.25 and 0.4 m/s 2 rms), and along both the axis (0.28 and 0.4 m/s 2 rms along each axis) in the 0.5-20 Hz frequency range. The two methods resulted in identical single-axis responses but considerably different dual-axis responses. The dual-axis responses derived from the Hv estimator revealed notable effects of dual-axis vibration, as they comprised both the direct and cross-axis responses observed under single axis vibration. Such effect, termed as the coupling effect, was not evident in the dual-axis responses derived using the commonly used H1 estimator. The results also revealed significant effects of hands and back support conditions on the coupling effects and the measured responses. The back support constrained the upper body movements and thus showed relatively weaker coupling compared to that observed in the responses without the back support. The effect of hand support was also pronounced under the fore-aft vibration. The results suggest that a better understanding of the seated human body responses to

  20. Animating the biodynamics of soil thickness using process vector analysis: A dynamic denudation approach to soil formation

    Science.gov (United States)

    Johnson, D.L.; Domier, J.E.J.; Johnson, D.N.

    2005-01-01

    This paper expands the dynamic denudation framework of landscape evolution by providing new process insights and details on how soil and its signature morphological feature, the biomantle, form and function in the environment. We examine soils and their biomantles from disparate parts of the world, from the tropics through midlatitudes and hyperarid through perhumid, a range that exhibits varying environments for, and of, life. We then explicate the process pathways that cause soils to thicken and thin, and to even disappear, then reform. We do this by examining thickness relationships, where soil thickness stand biomantle thickness bt are functions of upbuilding u and deepening d minus removal r processes, hence st/bt=f(u+d-r). Upbuilding has two subsets, u1, which includes all exogenous (allochthonous-outside) mineral and/or organic inputs to the soil system, and u2, which includes all endogenous (autochthonous-in situ) processes and productions, including weathering. Exogenous u1 inputs include eolian and slopewash inputs (sedimentations) of mineral and organic materials, mass wasting accumulations and the like. Endogenous u2 processes and productions include the sum of in situ bioturbations, biosynthetic productions, organic accumulations, biovoid productions, weathering and volume increases caused by their sum. Endogenous upbuildings, which dominantly occur in the biomantle, are basically biodynamic bd processes and productions, hence u2=bd. Therefore, if exogenous upbuildings u1 are minimal or zero, then biomantle thickness bt is expressed by bt=f(u2-r) or bt=f(bd-r). Drawing on these relationships, we employ a graphic-conceptual device called process vector analysis in a digital animation (see supplementary materials or cf. https://netfiles.uiuc.edu/jdomier/www/temp/ biomantle.html) that illustrates the main pathways that form both Earth's soil and its unique epidermis, the biomantle. We then discuss the main elements of the animation using still frames that

  1. Biodynamic Response to Windblast.

    Science.gov (United States)

    1975-07-01

    interiour. Liamplitude do ce wouvement do Ia jambe vors Il’xtnieiur a At& rondu possible par Is dislocation lombu- sacro -iliaque ot Ia jambe gaucho qui...applied to the diver’s body art distributed to iji ne citenilt, and atter 40 ft./sec. (0 ft. immession) they appear more all, a suction dittribulion

  2. Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete – Part I: Relative importance of water and sediment as exposure routes

    Energy Technology Data Exchange (ETDEWEB)

    Ramskov, Tina, E-mail: tramskov@hotmail.com [Department of Environmental, Social and Spatial Change, Roskilde University, PO Box 260, Universitetsvej 1, DK-4000 Roskilde (Denmark); US Geological Survey, 345 Middlefield Road, Menlo Park, CA 94025 (United States); Thit, Amalie, E-mail: athitj@ruc.dk [Department of Environmental, Social and Spatial Change, Roskilde University, PO Box 260, Universitetsvej 1, DK-4000 Roskilde (Denmark); Croteau, Marie-Noële, E-mail: mcroteau@usgs.gov [US Geological Survey, 345 Middlefield Road, Menlo Park, CA 94025 (United States); Selck, Henriette, E-mail: selck@ruc.dk [Department of Environmental, Social and Spatial Change, Roskilde University, PO Box 260, Universitetsvej 1, DK-4000 Roskilde (Denmark); US Geological Survey, 345 Middlefield Road, Menlo Park, CA 94025 (United States)

    2015-07-15

    Highlights: • Both aqueous and nanoparticulate Cu forms are available for uptake by L. variegatus. • Cu accumulation is driven by both water and sediment uptake. • Cu form weakly influences Cu biodynamics in L. variegatus. • Food ingestion rate is a sensitive endpoint for dietborne Cu exposure. • Stable isotope tracers allow detecting accumulation after environmentally relevant exposures. - Abstract: Copper oxide (CuO) nanoparticles (NPs) are widely used, and likely released into the aquatic environment. Both aqueous (i.e., dissolved Cu) and particulate Cu can be taken up by organisms. However, how exposure routes influence the bioavailability and subsequent toxicity of Cu remains largely unknown. Here, we assess the importance of exposure routes (water and sediment) and Cu forms (aqueous and nanoparticulate) on Cu bioavailability and toxicity to the freshwater oligochaete, Lumbriculus variegatus, a head-down deposit-feeder. We characterize the bioaccumulation dynamics of Cu in L. variegatus across a range of exposure concentrations, covering both realistic and worst-case levels of Cu contamination in the environment. Both aqueous Cu (Cu-Aq; administered as Cu(NO{sub 3}){sub 2}) and nanoparticulate Cu (CuO NPs), whether dispersed in artificial moderately hard freshwater or mixed into sediment, were weakly accumulated by L. variegatus. Once incorporated into tissues, Cu elimination was negligible, i.e., elimination rate constants were in general not different from zero for either exposure route or either Cu form. Toxicity was only observed after waterborne exposure to Cu-Aq at very high concentration (305 μg L{sup −1}), where all worms died. There was no relationship between exposure route, Cu form or Cu exposure concentration on either worm survival or growth. Slow feeding rates and low Cu assimilation efficiency (approximately 30%) characterized the uptake of Cu from the sediment for both Cu forms. In nature, L. variegatus is potentially exposed to Cu

  3. Biodynamic analysis of basketball shooting skills based on 3-D view analysis%基于三维图像解析的篮球投篮技术生物力学分析

    Institute of Scientific and Technical Information of China (English)

    徐艳; 袁同春; 柴业宏

    2012-01-01

    By utilizing the literature method, observation method and biodynamic analysis, the shooting skills of basketball athletes are analyzed based on the 3-D videos, and the characteristics of the movements of athletes' knee joints, hands and the motion of the ball are investigated. It is demonstrated that as long as the relationship among the coordination of the exerting of upper and lower limbs, the height and angel of shooting hands and the movements of shooting the ball is well balanced, the hit rate of shooting will be greatly improved. The conclusions obtained from this study will provide the theoretical instruction for the coaches and athletes in the basketball teaching and training.%文章采用文献资料法、观察法以及运动生物力学分析法,对篮球运动员的投篮技术进行三维录像及解析,分析了运动员的各主要运动关节运动特征、投篮手动作以及球的运动特征.研究表明运动员只有在投篮时处理好上下肢的协调用力、出手点高度和角度以及球出手瞬间动作的关系,才能真正提高投篮的命中率.研究结果将为提高广大教练员、运动员的篮球教学、训练水平提供有益的理论依据.

  4. Molecular Biodynamers : Dynamic Covalent Analogues of Biopolymers

    NARCIS (Netherlands)

    Liu, Yun; Lehn, Jean-Marie; Hirsch, Anna K H

    2017-01-01

    Constitutional dynamic chemistry (CDC) features the use of reversible linkages at both molecular and supramolecular levels, including reversible covalent bonds (dynamic covalent chemistry, DCC) and noncovalent interactions (dynamic noncovalent chemistry, DNCC). Due to its inherent reversibility and

  5. Niche farm fresh products: organic and biodynamic

    DEFF Research Database (Denmark)

    Jensen, Annette Nygaard; Baggesen, Dorte Lau

    2013-01-01

    There has been a general increase in demand for ‘organic’ or ‘biodynamic’ produce. As mineral nitrogen fertilizers are prohibited in organic farming, livestock manure often becomes the central fertilizer. Livestock manure is a known potential source of human pathogens, so it can be speculated...... that the observed increase in vegetable-associated foodborne outbreaks of pathogens is linked to its use. Legislation and guidelines vary regarding minimization of contamination risk in relation to use of livestock manure. An assessment of the effect of differences in management between organic and conventional...

  6. Biokinetics and Biodynamics of Nanomaterial Interactions

    Science.gov (United States)

    2009-09-30

    al., 2003), multi- walled carbon nanotubes (Monteiro-Riviere et al., 2005), 6-aminohexanoic acid- functionalized single-walled carbon nanotubes (Zhang...fullerene-based amino acid (Rouse et al., 2006), functionalized single-wall carbon nanotubes (SWCNT) (Zhang et al., 2007), QD (Ryman-Rasmussen et al...Wang, X., Pei , R., Yan, T., Zhoa, Y., Guo, X. 2005. Cytotoxicity of carbon nanomaterials: single-wall nanotube , multi-wall nanotube , and fullerene

  7. Pós-graduação na educação física brasileira: a atração (fatal para a biodinâmica Graduate studies in Brazilian physical education: the (fatal attraction to biodynamics

    Directory of Open Access Journals (Sweden)

    Edison de Jesus Manoel

    2011-08-01

    of physical education in North America and in Brazil. Next, the analysis of the areas comprehended by graduate study programs was carried out in the field around Brazil. A survey was done considering the field of concentration and its interface and links with the size of faculty, with research lines and with research projects. Physical education is the most preferred term to name the majority of the Brazilian graduate programs in contrast with the United States where Kinesiology is preferred. The analysis of the field of concentration yields three main subfields: biodynamics, sociocultural and pedagogical. Biodynamics takes precedence as one considers the size of the faculty and the number of research lines and projects always greater than the same variables in comparison with sociocultural and pedagogical subfields. This hegemony reflects a trend in which natural sciences-oriented research is privileged over human and social sciences-oriented research and difficulty in valuing the intervention, especially in schooling. This portrait resembles what happens in the US as some North American scholars from the sociocultural and pedagogical subfields have also identified difficulties in making their theoretical and methodological conceptions compatible with the hegemonic modes of thinking and investigation in kinesiology.

  8. Biodynamic Assessment of the THOR-K Manikin

    Science.gov (United States)

    2013-09-01

    With shutter speeds as low as 2 microseconds, TDAS PRO G5 DAS 13 Distribution A: Approved for public release; distribution unlimited. 88 ABW...Manikin Type No. of Impacts Helmet A1 +Z Spinal 10 30 10 THOR-K 2 No A2 +Z Spinal 10 30 10 THOR-K 1 HGU-55/P A3 +Z Spinal 10 30 10 H-III AERO 1 HGU-55...P B1 Y Lateral 10 30 10 THOR-K 2 No B2 Y Lateral 10 30 10 H-III AERO 1 No C1 Y Lateral 10 70 11 H-III AERO 1 No C2 Y Lateral 10 70 11 THOR-K 2 No

  9. An ultrasonic--EMG transducer for biodynamic research.

    Science.gov (United States)

    Watkin, K L; Minifie, F D; Kennedy, J G

    1978-03-01

    This note describes a newly developed single-element muscle action potential/motion transducer. The transcuer was specially designed for speech research. Techniques for use of the transducer are described. Sample data are presented illustrating the capability of the transducer, and applications of the device are discussed.

  10. Design and Development of an Enhanced Biodynamic Manikin. Phase 1

    Science.gov (United States)

    1994-08-01

    AR 2.10.3 System Monitor JuSto -,; 2.10.4 Acquisition . . ......................... 2.10.5 Data Transfer By 2.10.6 Calibration . . .... 2.10.7...design is probably the rugged ejection seat dummy built by Sierra Engineering Company for the Air Force about 1949. Although it had limited...standardization. Alderson upgraded their designs to meet J963 in 1968 and 1971, while the Sierra counterpart appeared in 1970. Todays most commonly

  11. Remote monitoring of biodynamic activity using electric potential sensors

    Energy Technology Data Exchange (ETDEWEB)

    Harl, C J; Prance, R J; Prance, H [Centre for Physical Electronics and Quantum Technology, Department of Engineering and Design, School of Science and Technology, University of Sussex, Brighton, BN1 9QT (United Kingdom)], E-mail: c.j.harland@sussex.ac.uk

    2008-12-01

    Previous work in applying the electric potential sensor to the monitoring of body electrophysiological signals has shown that it is now possible to monitor these signals without needing to make any electrical contact with the body. Conventional electrophysiology makes use of electrodes which are placed in direct electrical contact with the skin. The electric potential sensor requires no cutaneous electrical contact, it operates by sensing the displacement current using a capacitive coupling. When high resolution body electrophysiology is required a strong (capacitive) coupling is used to maximise the collected signal. However, in remote applications where there is typically an air-gap between the body and the sensor only a weak coupling can be achieved. In this paper we demonstrate that the electric potential sensor can be successfully used for the remote sensing and monitoring of bioelectric activity. We show examples of heart-rate measurements taken from a seated subject using sensors mounted in the chair. We also show that it is possible to monitor body movements on the opposite side of a wall to the sensor. These sensing techniques have biomedical applications for non-contact monitoring of electrophysiological conditions and can be applied to passive through-the-wall surveillance systems for security applications.

  12. Comparison of Biodynamic Responses in Standing and Seated Human Bodies

    Science.gov (United States)

    MATSUMOTO, Y.; GRIFFIN, M. J.

    2000-12-01

    The dynamic responses of the human body in a standing position and in a sitting position have been compared. The apparent mass and transmissibilities to the head, six locations along the spine, and the pelvis were measured with eight male subjects exposed to vertical whole-body vibration. In both postures, the principal resonance in the apparent mass occurred in the range 5-6 Hz, with slightly higher frequencies and lower apparent mass in the standing posture. There was greater transmission of vertical vibration to the pelvis and the lower spine and greater relative motion within the lower spine in the standing posture than in the sitting posture at the principal resonance and at higher frequencies. Transmissibilities from the supporting surface (floor or seat) to the thoracic region had similar magnitudes for both standing and sitting subjects. The lumbar spine has less lordosis and may be more compressed and less flexible in the sitting posture than in the standing posture. This may have reduced the relative motions between lumbar vertebrae and both the supporting vibrating surface and the other vertebrae in the sitting posture. The characteristics of the vibration transmitted to the pelvis may have differed in the two postures due to different transmission paths. Increased forward rotation of the pelvis in the standing posture may have caused the differences in responses of the pelvis and the lower spine that were observed between the two postures.

  13. Impedance spectroscopy in biodynamics: Detection of specific cells (pathogens using immune coated electrodes

    Directory of Open Access Journals (Sweden)

    Eugen Gheorghiu

    2002-11-01

    Full Text Available We describe the theoretical and experimental approaches for monitoring the interfacial biomolecular reaction between immobilized antibody and the antigen binding partner (the analyte, or the targeted cell using Impedance Spectroscopy, IS. The key idea is to reveal the presence of the analyte by investigating the dynamics of the impedance changes at the interface between transducer and bulk during the process of antibody-antigen binding (coupling of specific compounds to sensor surface. In this work, antibody-antigen (Ab-Ag reaction was directly monitored using an impedance analyzer capable of ~ 1 measurement/second and covalent immobilization chemistry and modified electrodes in the absence of a redox probe. The proposed approach may be applicable to monitoring other surface interfacial reactions such as protein-protein interactions, DNA-DNA interactions, DNA-protein interactions and DNA-small molecule interactions.

  14. Modeling the Biodynamical Response of the Human Thorax with Body Armor from a Bullet Impact

    Science.gov (United States)

    2001-03-01

    are continuous with the osseous tissue of the rib that it belongs to. The inner extremity of the coastal cartilage for the first rib pair is... accidents , led to additional developments of the finite element model of the thorax. Chen [Ref. 61 developed a finite element model of the human thorax... accident . Their model assumed linear elastic material properties except for the internal organs that were modeled as a viscoelastic material. Their

  15. Establishing the Biodynamics Data Resource (BDR): Human Volunteer Impact Acceleration Research Data in the BDR

    Science.gov (United States)

    2009-10-01

    experienced pain , the acceleration level was either repeated for reliability or was increased by 1 to 2 Gs. Thus the volunteers stationed at NBDL...Neck Ht Axilla Ht Suprasternale Ht Substernale Ht 10th Rib Ht Waist Ht (Omph) Iliocristale Ht ASIS Ht Trochanterion Ht Gluteal Furrow Ht Tibiale

  16. A New Skin Tensiometer Device: Computational Analyses To Understand Biodynamic Excisional Skin Tension Lines.

    Science.gov (United States)

    Paul, Sharad P; Matulich, Justin; Charlton, Nick

    2016-07-25

    One of the problems in planning cutaneous surgery is that human skin is anisotropic, or directionally dependent. Indeed, skin tension varies between individuals and at different body sites. Many a surgeon has tried to design different devices to measure skin tension to help plan excisional surgery, or to understand wound healing. However, many of the devices have been beset with problems due to many confounding variables - differences in technical ability, material (sutures) used and variability between different users. We describe the development of a new skin tensiometer that overcomes many historical technical issues. A new skin tension measuring device is presented here. It was designed to be less user-dependent, more reliable and usable on different bodily sites. The design and computational optimizations are discussed. Our skin tensiometer has helped understand the differences between incisional and excisional skin lines. Langer, who pioneered the concept of skin tension lines, created incisional lines that differ from lines caused by forces that need to be overcome when large wounds are closed surgically (excisional tension). The use of this innovative device has led to understanding of skin biomechanics and best excisional skin tension (BEST) lines.

  17. A New Skin Tensiometer Device: Computational Analyses To Understand Biodynamic Excisional Skin Tension Lines

    OpenAIRE

    Paul, Sharad P.; Justin Matulich; Nick Charlton

    2016-01-01

    One of the problems in planning cutaneous surgery is that human skin is anisotropic, or directionally dependent. Indeed, skin tension varies between individuals and at different body sites. Many a surgeon has tried to design different devices to measure skin tension to help plan excisional surgery, or to understand wound healing. However, many of the devices have been beset with problems due to many confounding variables - differences in technical ability, material (sutures) used and variabil...

  18. Bibliography of Research Reports and Publications Issued by the Biodynamics and Bioengineering Division, 1944-1984.

    Science.gov (United States)

    1985-04-01

    Report 65-133, (AD 670161) L-62 R.E. Van Patten, R. Gaudio, "Application of the Ranque Hilsch Vortex Tube to Air Crew Cooling Problems", June 1968...Patten, R. Gaudio, " Vortex Tube as a Thermal Protective Device", Aerospace Medicine, Vol. 40, No. 3, March 1969 Section L- Page 158 Miscellaneous L-68 G.C...at Hill Air Force Base" WADC Technical Note 56-58, August 1956, (AD 110645) B-29 K.W. Goff, D.M.A. Mercer, "Probe Tube Microphone for Use in High

  19. Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete, Part I

    DEFF Research Database (Denmark)

    Ramskov, Tina; Thit, Amalie; Croteau, Marie-Noelle

    2015-01-01

    Copper oxide (CuO) nanoparticles (NPs) are widely used, and likely released into the aquatic environment. Both aqueous (i.e., dissolved Cu) and particulate Cu can be taken up by organisms. However, how exposure routes influence the bioavailability and subsequent toxicity of Cu remains largely...

  20. Chemical Biodynamics Division: Annual report, October 1, 1986-September 30, 1987

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    Investigators are studying the various components that make up the photosynthetic reaction center complexes in many different organisms. This work not only involves understanding the kinetics of energy transfer and storage in plants, but also includes studies to work out how photosynthetic cells regulate the expression of genes encoding the photosynthetic apparatus. The second biological theme is a series of investigations into the relationship between structure and function in nucleic acids. Our basic mission in this program is to couple our chemical and biophysical expertise to understand how not only the primary structure of nucleic acids, but also higher levels of structure including interactions with proteins and other nucleic acids regulate the functional activity of genes. In the chemical sciences investigators are increasing our understanding of the fundamental chemistry of electronically excited molecules, a critical dimension of every photosynthetic energy storage process. We are developing approaches not only toward the utilization of sophisticated chemistry to store photon energy, but also to develop systems that can emulate the photosynthetic apparatus in the trapping and transfer of photosynthetic energy. Individual projects are processed separately for the data base.

  1. Models and Analogues for the Evaluation of Human Biodynamic Response, Performance and Protection

    Science.gov (United States)

    1979-06-01

    was used fot initial condition -X experiments. Figure 2 presents the average sled eccele asian profiles for 7G, *Y experlments. Again, HOLD profile...0039 47 AT TI UNITS OF COEFFICIENTS CONSISTENT WITH: ANGLE RADIANS LENGTH METERS TIME - SEC. Table I - Reriesolon Coff ;clnts for the Effect of HOLD

  2. Bionics and Biocybernetics Bibliography, Biodynamics and Bioengineering Division 1959-1980.

    Science.gov (United States)

    1986-09-01

    W.S. McCulloch , W.H. Pitts , "A Theory of Passive Ion Flux Through Axon Membranes", Nature, Vol. 202, pp 1138-1139, 1964 4-. M-67 W.S. McCulloch ...December 1960 M-9 W.S. McCulloch , "Symbolic Representation of the Neuron as an Unreliable Function", Principles of Self Organization, Pergamon Press...Vol. 55, pp 505-515, 1962 M-18 W.S. McCulloch , M.A. Arbib, J.D. Cowan, "Neurological Models and Integrative Processes", Self-Organizing Systems

  3. Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete - Part II: Subcellular distribution following sediment exposure

    Science.gov (United States)

    Thit, Amalie; Ramskov, Tina; Croteau, Marie-Noele; Selck, Henriette

    2016-01-01

    The use and likely incidental release of metal nanoparticles (NPs) is steadily increasing. Despite the increasing amount of published literature on metal NP toxicity in the aquatic environment, very little is known about the biological fate of NPs after sediment exposures. Here, we compare the bioavailability and subcellular distribution of copper oxide (CuO) NPs and aqueous Cu (Cu-Aq) in the sediment-dwelling worm Lumbriculus variegatus. Ten days (d) sediment exposure resulted in marginal Cu bioaccumulation in L. variegatus for both forms of Cu. Bioaccumulation was detected because isotopically enriched 65Cu was used as a tracer. Neither burrowing behavior or survival was affected by the exposure. Once incorporated into tissue, Cu loss was negligible over 10 d of elimination in clean sediment (Cu elimination rate constants were not different from zero). With the exception of day 10, differences in bioaccumulation and subcellular distribution between Cu forms were either not detectable or marginal. After 10 d of exposure to Cu-Aq, the accumulated Cu was primarily partitioned in the subcellular fraction containing metallothionein-like proteins (MTLP, ≈40%) and cellular debris (CD, ≈30%). Cu concentrations in these fractions were significantly higher than in controls. For worms exposed to CuO NPs for 10 d, most of the accumulated Cu was partitioned in the CD fraction (≈40%), which was the only subcellular fraction where the Cu concentration was significantly higher than for the control group. Our results indicate that L. variegatus handle the two Cu forms differently. However, longer-term exposures are suggested in order to clearly highlight differences in the subcellular distribution of these two Cu forms.

  4. Biodynamics helps wine find its innger grape%"生物动力学"葡萄生产正兴起

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ 目前,越来越多的葡萄酒厂正在用"生物动力学"这个术语,它是上世纪20年代由奥地利人Rudolf Steiner 提出的.Steiner指出农业耕作应该在没有额外增加的自我循环系统下进行,也就说"生物动力学"是一个生物耕作类型,提倡减少化学农药和肥料的使用.

  5. Analysis of a bio-dynamic model via Lyapunov principle and small-world network for tuberculosis.

    Science.gov (United States)

    Chung, H-Y; Chung, C-Y; Ou, S-C

    2012-10-01

    The study will apply Lyapunov principle to construct a dynamic model for tuberculosis (TB). The Lyapunov principle is commonly used to examine and determine the stability of a dynamic system. To simulate the transmissions of vector-borne diseases and discuss the related health policies effects on vector-borne diseases, the authors combine the multi-agent-based system, social network and compartmental model to develop an epidemic simulation model. In the identity level, the authors use the multi-agent-based system and the mirror identity concept to describe identities with social network features such as daily visits, long-distance movement, high degree of clustering, low degree of separation and local clustering. The research will analyse the complex dynamic mathematic model of TB epidemic and determine its stability property by using the popular Matlab/Simulink software and relative software packages. Facing the current TB epidemic situation, the development of TB and its developing trend through constructing a dynamic bio-mathematical system model of TB is investigated. After simulating the development of epidemic situation with the solution of the SMIR epidemic model, the authors will come up with a good scheme to control epidemic situation to analyse the parameter values of a model that influence epidemic situation evolved. The authors will try to find the quarantining parameters that are the most important factors to control epidemic situation. The SMIR epidemic model and the results via numerical analysis may offer effective prevention with reference to controlling epidemic situation of TB.

  6. A Study of the Biodynamic Changes in Perthes' Disease%Perthes病生物力学变化的初步探讨

    Institute of Scientific and Technical Information of China (English)

    许加铭; 章锦

    1991-01-01

    取本院治疗的Perthes病40例的双髋正位X线片作观察.测量其颈干角、HE角、CE角,大粗隆高及头-臼关系变化等,并从髋关节扭矩力、髋周肌力平衡及股骨上端骨骺生长应力等方面探讨本病生物力学变化.%X-ray films of both hip joints of 41 patients with Perthe' disease were studied. There were 11 cases of Catterall stage Ⅱ.5 stage Ⅲ and 24 stage Ⅳ.Results of measurement:the cervicodiaphyseal angle<135°11 cases,>135°25 cases and=135°4 cases.Changes of the CD angle were correlated to the site of damage of the epiphyseal plate of the femur.HE angle varied Wom 14°to 30°,everage 20°,in normal but from 8°to 18°,average 14.8°,in Perthes' disease(P<0.05).In 35 cases,the greater trochanter of the affected side measured 7.8 mm on average higher than the other side,varied from 3 to 24mm as the stage of the disease.CE angle ranged from 12°to 40°:32 cases<30°and 8 cases>30° also varied as the stage of the disease.There were 28 hip subluxations in this series.The acetabulum appeared enlarged and shallower than normal.All the alove mentioned changes are suppored due to the imhalance of the periarticulas muscler of the hip.

  7. Effect of fresh grass feeding, pasture grazing and organic/biodynamic farming on bovine milk triglyceride profile and implications for authentication

    NARCIS (Netherlands)

    Capuano, E.; Boerrigter-Eenling, G.R.; Eigersma, A.; Ruth, van S.M.

    2014-01-01

    In the present study, 113 tank milk samples were collected from 30 farms located in the Netherlands and analyzed for their triacylglycerol (TAG) and cholesterol profiles. Significant differences in the TAG profile between winter and spring–early summer milk were observed. The differences between mil

  8. Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete: Part I: relative importance of water and sediment as exposure routes

    Science.gov (United States)

    Ramskov, Tina; Thit, Amalie; Croteau, Marie-Noele; Selck, Henriette

    2015-01-01

    Copper oxide (CuO) nanoparticles (NPs) are widely used, and likely released into the aquatic environment. Both aqueous (i.e., dissolved Cu) and particulate Cu can be taken up by organisms. However, how exposure routes influence the bioavailability and subsequent toxicity of Cu remains largely unknown. Here, we assess the importance of exposure routes (water and sediment) and Cu forms (aqueous and nanoparticulate) on Cu bioavailability and toxicity to the freshwater oligochaete, Lumbriculus variegatus, a head-down deposit-feeder. We characterize the bioaccumulation dynamics of Cu in L. variegatus across a range of exposure concentrations, covering both realistic and worst-case levels of Cu contamination in the environment. Both aqueous Cu (Cu-Aq; administered as Cu(NO3)2) and nanoparticulate Cu (CuO NPs), whether dispersed in artificial moderately hard freshwater or mixed into sediment, were weakly accumulated by L. variegatus. Once incorporated into tissues, Cu elimination was negligible, i.e., elimination rate constants were in general not different from zero for either exposure route or either Cu form. Toxicity was only observed after waterborne exposure to Cu-Aq at very high concentration (305 µgL-1), where all worms died. There was no relationship between exposure route, Cu form or Cu exposure concentration on either worm survival or growth. Slow feeding rates and low Cu assimilation efficiency (approximately 30%) characterized the uptake of Cu from the sediment for both Cu forms. In nature, L. variegatus is potentially exposed to Cu via both water and sediment. However, sediment progressively becomes the predominant exposure route for Cu in L. variegatus as Cu partitioning to sediment increases.

  9. Biodynamic and kinematic characteristics of hemiplegic gait following stroke%中风偏瘫步态的生物力学及其运动学特征分析

    Institute of Scientific and Technical Information of China (English)

    王桂茂; 齐瑞; 严隽陶

    2007-01-01

    目的:偏瘫步态是脑卒中引起的常见后遗症之一,分析偏瘫步态的运动学规律,可以加深对偏瘫步态病理特点的认识,从生物力学的角度有效指导患者的运动训练.方法:应用计算机检索中国期刊全文数据库1995-01/2006-12的相关文章,检索词"偏瘫步态,运动解析",限定文章语言种类为中文.获得文章51篇.同时计算机检索PubMed Central 1990-01/2006-12的相关文章,检索词"hemiplegic gait,gait analysis",限定文章语言种类为Erlglish,获得文章32篇.对资料进行初审.纳入标准:关于中风偏瘫步态运动学基础研究方面的文章.排除标准:重复性研究.对所得文献进行提炼,获得符合要求的文章29篇.其中RCT文章6篇,经验交流4篇.属于运动学或生物力学基础研究的文章19篇.结果:偏瘫步态是脑卒中引起的常见后遗症之一,也是全身功能异常的一种表现,具有显著地运动变化特征.可从其与正常步态的对比、基本的时一空参数分析、步态的对称性、重心的变化、躯体和骨盆的运动、下肢关节运动、健侧下肢与正常下肢的运动比较等几个方面对其进行运动学分析,从而加深对偏瘫步态的认识.本文主要阐述了偏瘫步态的运动学分析,临床康复治疗中,常通过骨盆控制训练与下肢协调性训练等以达到改善偏瘫步态,提高生活质量的目的,因而分析并明确骨盆与下肢关节运动中何者为影响步行能力的关键因素,将有助于明确训练中的侧重点.结论:分析偏瘫步态的运动规律,从生物力学的角度优化康复治疗方案,可对功能恢复产生重要的作用.

  10. Community Noise Exposure Resulting from Aircraft Operations: Technical Review

    Science.gov (United States)

    1974-11-01

    approved for publication. FOR THE COMMANDER HENHllGiJE. VOM GIERKE Director Biodynamics and Bionics Division Aerospace Medical Research...content, critical review, and suggestions by Jerry D. Speakman and John N. Cole of the Biodynamics and Bionics Division, Aerospace Medical Research...reasons for some of the basic decisions in the architecture of the computer program. We are basically accumulating NEF(ij) at our grid points. It is

  11. Design and Evaluation Methods for Optimizing Ejection Seat Cushions for Comfort and Safety

    Science.gov (United States)

    1977-02-01

    THE COMMANDER HENNI VON GIERKE Director Biodynamics and Bionics Division Aerospace Medical Research Laboratory LIMd SUMMARY [ A method for...investigation was initiated by the Vibration and Impact Branch, Biodynamics and Bionics Division, Aerospace Medical Research Laboratory, Wright-Patterson...subject’s eyes were aligned with a present mark on the head rest. The foot rests were also checked to insure that the subject’s knees were slightly

  12. 32nd IMAC Conference and Exposition on Structural Dynamics

    CERN Document Server

    Mayes, Randy; Rixen, Daniel; Catbas, Fikret; Atamturktur, H; Moaveni, Babak; Papadimitriou, Costas; Schoenherr, Tyler; Foss, Gary; Niezrecki, Christopher; Allemang, Randall; Kerschen, Gaetan

    2014-01-01

    This critical collection examines a range of topics in modal analysis, from experimental techniques to acoustics to biodynamics,  as presented in early findings and case studies from the Proceedings of the 32nd IMAC, A Conference and Exposition on Structural Dynamics, 2014. The collection includes papers in the following general technical research areas: Experimental Techniques, Processing Modal Data, Rotating Machinery, Acoustics, Adaptive Structures, Biodynamics, Damping

  13. Pós-graduação na educação física brasileira: a atração (fatal) para a biodinâmica Graduate studies in Brazilian physical education: the (fatal) attraction to biodynamics

    OpenAIRE

    2011-01-01

    O objetivo do trabalho foi caracterizar academicamente a educação física no Brasil. Primeiro, fez-se um paralelo entre os eventos desse processo ocorridos nos Estados Unidos e no Brasil. A seguir, os programas de pós-graduação brasileiros foram analisados do ponto de vista de suas áreas de concentração e de sua vinculação com o corpo docente, as linhas e os projetos de pesquisa. Educação física é o termo predominante na denominação da maioria dos programas brasileiros, diferentemente dos Esta...

  14. DETERMINATION OF THE GLYCOALKALOIDS CONTENT FROM POTATO TUBERCULES (SOLANUM TUBEROSUM

    Directory of Open Access Journals (Sweden)

    NORGIA WIDMANN

    2013-12-01

    Full Text Available Determinations concerning the glycoalkaloids content were made over four potato varieties (Hansa, Sieglinde, Nicola and Linda obtained from a private German source, country in which potatoes are cultivated and consumed frequently. Potatoes have been cultivated in classic conditions, as well as in biodynamic conditions.The glycoalkaloids complex and their aglycones had been obtained through a sequence of operations, like extractions with several specific solvents at reflux and in backward flow, hydrolysis, lyophilisation etc.The determinations concerning the glycoalcaloids content of the four studied potato varieties were accomplished comparatively for both culture modes, in classic and biodynamic conditions.

  15. Study on Virtual Human Skeleton System

    Institute of Scientific and Technical Information of China (English)

    郭巧; 李亦

    2004-01-01

    A solution of virtual human skeleton system is proposed. Some issues on integration of anatomical geometry, biodynamics and computer animation are studied. The detailed skeleton system model that incorporates the biodynamic and geometric characteristics of a human skeleton system allows some performance studies in greater detail than that performed before. It may provide an effective and convenient way to analyze and evaluate the movement performance of a human body when the personalized anatomical data are used in the models. An example shows that the proposed solution is effective for the stated problems.

  16. Comparison of landscape features in organic and conventional farming systems.

    NARCIS (Netherlands)

    Mansvelt, van J.D.; Stobbelaar, D.J.; Hendriks, K.

    1998-01-01

    Four organic (biodynamic) farms coupled with conventional farms from their neighbourhood in The Netherlands, Germany and Sweden, and 3 organic farms and 4 conventional farms from the West Friesean region in The Netherlands were evaluated to compare their impact on landscape diversity. Materials used

  17. Life sciences

    Energy Technology Data Exchange (ETDEWEB)

    Day, L. (ed.)

    1991-04-01

    This document is the 1989--1990 Annual Report for the Life Sciences Divisions of the University of California/Lawrence Berkeley Laboratory. Specific progress reports are included for the Cell and Molecular Biology Division, the Research Medicine and Radiation Biophysics Division (including the Advanced Light Source Life Sciences Center), and the Chemical Biodynamics Division. 450 refs., 46 figs. (MHB)

  18. Geographical provenancing of purple grape juices from different farming systems by proton transfer reaction mass spectrometry using supervised statistical techniques

    NARCIS (Netherlands)

    Granato, Daniel; Koot, Alex; Ruth, van S.M.

    2015-01-01

    BACKGROUND: Organic, biodynamic and conventional purple grape juices (PGJ; n = 79) produced in Brazil and Europe were characterized by volatile organic compounds (m/z 20-160) measured by proton transfer reaction mass spectrometry (PTR-MS), and classification models were built using supervised sta

  19. Produktie en afzet van BD- en EKO - produkten

    NARCIS (Netherlands)

    Kleijn, de E.H.J.M.; Groenwold, J.G.; Hack, M.D.

    1990-01-01

    This is the report of a research on the structure and general results of biodynamic and ecological agriculture in The Netherlands. Questionnaires and interviews are used to gather data on the primary production, marketing and processing. The demand and consumer aspects are analysed with the help of

  20. Verification of fresh grass feeding, pasture grazing and organic farming by cows farm milk fatty acid profile

    NARCIS (Netherlands)

    Capuano, E.; Veer, van der G.; Boerrigter-Eenling, G.R.; Elgersma, A.; Rademaker, J.; Sterian, A.; Ruth, van S.M.

    2014-01-01

    The present study investigated the use of fatty acid (FA) profiling in combination with chemometric modelling to verify claims for cow milk in terms of fresh grass feeding, pasture grazing and organic/biodynamic farming. The FA profile was determined for 113 tank milk samples collected in the Nether

  1. Educational and Training Opportunities in Sustainable Agriculture. 5th Edition.

    Science.gov (United States)

    Gates, Jane Potter

    This directory lists 151 programs in alternative farming systems (systems that aim at maintaining agricultural productivity and profitability, while protecting natural resources, especially sustainable, low-input, regenerative, biodynamic or organic farming and gardening). It includes programs conducted by colleges and universities, research…

  2. Sustainable Agriculture in Print: Current Books. Special Reference Briefs: SRB 95-02.

    Science.gov (United States)

    National Agricultural Library, Beltsville, MD.

    Prepared by the Alternative Farming Systems Information Center (AFSIC) staff and volunteers, this annotated bibliography provides a list of 85 recently published books pertaining to sustainable agriculture. AFSIC focuses on alternative farming systems (e.g., sustainable, low-input, regenerative, biodynamic, and organic) that maintain agricultural…

  3. Scaling head-neck response data and derivation of 5th percentile female side-impact dummy head-neck response requirements in NBDL test conditions

    NARCIS (Netherlands)

    Meijer, R.; Wisgerhof, R.P.; Wismans, J.S.H.M.; Been, B.W.

    2009-01-01

    The head-neck biofidelity of side-impact dummies can be assessed according to the response requirements for the head-neck system based on mid-size male human subjects as published in ISO TR9790. These criteria are largely based on volunteer tests performed at the Naval Biodynamics Laboratory (NBDL)

  4. Lessons learned from a qualitative sustainability assessment method “Farm Talks”

    NARCIS (Netherlands)

    Olde, de E.M.; Derkzen, P.H.M.; Oudshoorn, Frank W.; Sorensen, C.A.G.

    2016-01-01

    This paper presents a qualitative peer review “Farm Talks” method which stimulates farmers’ learning beyond existing quantitative sustainability assessment tools. Farm Talks were started in 2008 by the biodynamic farming association and the Demeter organization in the Netherlands as a qualitative al

  5. Authentication of Geographical Origin and Crop System of Grape Juices by Phenolic Compounds and Antioxidant Activity Using Chemometrics

    NARCIS (Netherlands)

    Granato, D.; Koot, A.H.; Schnitzler, E.; Ruth, van S.M.

    2015-01-01

    The main goal of this work was to propose an authentication model based on the phenolic composition and antioxidant and metal chelating capacities of purple grape juices produced in Brazil and Europe in order to assess their typicality. For this purpose, organic, conventional, and biodynamic grape j

  6. De detailhandel in biologische produkten : de mogelijkheden voor supermarkten en speciaalzaken naast de natuurvoedingswinkels

    NARCIS (Netherlands)

    Borgstein, M.H.; Zimmermann, K.L.

    1993-01-01

    Qualitative research on the sale of biological products (biodynamic and ecological) in the supermarkets, specialist shops and natural food stores in The Netherlands and inventarisation of bottle-necks which prohibit this sale. Conditions are formulated for promoting the introduction of organic produ

  7. Verification of fresh grass feeding, pasture grazing and organic farming by cows farm milk fatty acid profile.

    Science.gov (United States)

    Capuano, Edoardo; van der Veer, Grishja; Boerrigter-Eenling, Rita; Elgersma, Anjo; Rademaker, Jan; Sterian, Adriana; van Ruth, Saskia M

    2014-12-01

    The present study investigated the use of fatty acid (FA) profiling in combination with chemometric modelling to verify claims for cow milk in terms of fresh grass feeding, pasture grazing and organic/biodynamic farming. The FA profile was determined for 113 tank milk samples collected in the Netherlands from 30 farms over four different months, and used to develop classification models based on the PLS-DA algorithm. Milk from cows with daily rations of fresh grass could be successfully distinguished from milk from cows with no fresh grass in their diet. Milk from cows at pasture could easily be distinguished from milk from stabled cows without fresh grass in the diet, but the correct prediction of milk from stabled cows fed fresh grass indoors proved difficult. The FA profile of organic/biodynamic milk was different compared to conventional milk but an unequivocal discrimination was not possible either in summer or in winter.

  8. Catalog of research projects at Lawrence Berkeley Laboratory, 1985

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This Catalog has been created to aid in the transfer of technology from the Lawrence Berkeley Laboratory to potential users in industry, government, universities, and the public. The projects are listed for the following LBL groups: Accelerator and Fusion Research Division, Applied Science Division, Biology and Medicine Division, Center for Advanced Materials, Chemical Biodynamics Division, Computing Division, Earth Sciences Division, Engineering and Technical Services Division, Materials and Molecular Research Division, Nuclear Science Division, and Physics Division.

  9. A Spine Loading Model of Women in the Military

    Science.gov (United States)

    1996-10-01

    all 11 scan levels. The quantified muscles include the right and left pairs of the erector spinae group, quadratus lumborum , latissimus dorsi...Biodynamics Laboratory at The Ohio State University Table 14. Trunk muscle cross sectional area and standard deviations 0 of the Right Quadratus Lumborum ...are also described. Right Quadratus Lumborum - Cross-Sectional Area Level OSU Male McGill et DifferenceA OSU Chaffin et DifferenceA Male vs meanA al

  10. Minimum Points and Views for the Recovery of Three-Dimensional Structure.

    Science.gov (United States)

    1986-06-20

    Leonesio, Arthur P. Shimamura, Robert F. Landwehr and Louis Narens, "Overlearning and the Feeling of Knowing" (July 1981). 5. Myron L. Braunstein...Biodynamics Laboratory Defense Intelligence College Michoud Station Washington, D.C. 20374 Box 29407 New Orleans, LA 70189 CDR C. Hutchins Code 55 Dr. Arthur ...Carnegie-Mellon University Computer Science Dept. Pittsburgh, PA 15213 Dr. David L. Kleinman Electrical Engineering & Computer Science Dept. University of Connecticut Storrs, CT 06268 9 4 I - i - - ,- U- ~

  11. Proceedings of the Combined Effects of Multiple Stressors on Operational Performance Held in San Diego, California on 4-5 April 1989

    Science.gov (United States)

    1989-04-05

    Submarine Medical Laboratory in Groton, an Aerospace Laboratory in Pensacola, a Naval Biodynamics Lab in New Orleans, and a Naval Dental Research Lab. We have...representatives here from all the labs, I think, except the dental lab, and you may hear from each of them This is our mission. It is a long...showed that roughly 50% of the incidents were related to human factor issues. We talked about Chernobyl ; we talked about Three Mile Island, and we

  12. Finite Element Analysis of the Effects of Head-Supported Mass on Neck Responses

    Science.gov (United States)

    2006-09-01

    head supported mass (HSM) increases the mass of the helmets worn by soldiers. Complaints of neck pain during and after flight have increased amongst...impact (AFRL Biodynamics Data Bank 199405-VDT3292) and lateral impact (Ewing et al. 1976). After tuning the activation of the neck musculature the KTH...the Cervical Intervertebral Disc During Simulated Whiplash , Spine, Vol. 29, Nr. 11, pp 1217-1225, 2004. Shanahan DF and Shanahan MO. Injury in US

  13. CHALCONE AS A VERSATILE MOIETY FOR DIVERSE PHARMACOLOGICAL ACTIVITIES

    OpenAIRE

    2012-01-01

    Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim of this review is to summarize chalcones and their diverse pharmacological activities like antican...

  14. Overviews of Emerging Research Techniques in Hearing, Bioacoustics, and Biomechanics: Proceedings of the 1981 Meeting

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    These proceedings of the 1981 annual meeting of the Committee on Hearing, Bioacoustics, and Biomechanics cover topics of emerging research in several areas of interest to the Committee. Topics covered include: hair cell function; transduction process of hair cells; speech synthesis; machine recognition of words; neuromagnetic analysis of sensory systems; tinnitus; tactile communication of speech; and biodynamic research at the Air Force Aerospace Medical Research Laboratory.

  15. Department of the Navy Supporting Data for Fiscal Year 1983 Budget Estimates Descriptive Summaries Submitted to Congress February 1982. Research, Development, Test & Evaluation, Navy. Book 1 of 3. Technology Base, Advanced Technology Development, Strategic Programs.

    Science.gov (United States)

    1982-02-01

    8217 fooring which has 200 sensors, is usable for one year, and has a satellite relay data line; transitioned to Advanced Development; * completed research...assessment of head, neck and pelvic effects of vertical impact acceleration and biodynamic effects of parachute-opening shock. Continue determination...dimensional head and neck prototype manikin. Begin comparison of head, neck, and pelvic effects of linear acceleration in the back-to-front vector on

  16. Research in psychopathology: epistemologic issues

    DEFF Research Database (Denmark)

    Parnas, Josef; Bovet, P

    1995-01-01

    (connectionism), and developmental psychology (developmental biodynamics) converge in viewing living organisms as self-organizing systems. In this perspective, the organism is not specified by the outer world, but enacts its environment by selecting relevant domains of significance that constitute its world....... The distinction between mind and body or organism and environment is a matter of observational perspective. These models from empirical sciences are compatible with fundamental tenets of philosophical phenomenology and hermeneutics. They imply consequences for research in psychopathology: symptoms cannot...

  17. Influences of sediment geochemistry on metal accumulation rates and toxicity in the aquatic oligochaete Tubifex tubifex

    OpenAIRE

    Mendez-Fernandez, L; M. de Jonge; Bervoets, L.

    2014-01-01

    Metal bioaccumulation and toxicity in the aquatic oligochaete Tubifex tubifex exposed to three metal-contaminated field-sediments was studied in order to assess whether sediment-geochemistry (AVS, TOC) plays a major role in influencing these parameters, and to assess if the biodynamic concept can be used to explain observed effects in T. tubifex tissue residues and/or toxicity. An active autotomy promotion was observed in three studied sediments at different time points and reproduction impai...

  18. Response of the seated human body to whole-body vertical vibration: discomfort caused by sinusoidal vibration.

    Science.gov (United States)

    Zhou, Zhen; Griffin, Michael J

    2014-01-01

    Frequency weightings for predicting vibration discomfort assume the same frequency-dependence at all magnitudes of vibration, whereas biodynamic studies show that the frequency-dependence of the human body depends on the magnitude of vibration. This study investigated how the frequency-dependence of vibration discomfort depends on the acceleration and the force at the subject-seat interface. Using magnitude estimation, 20 males and 20 females judged their discomfort caused by sinusoidal vertical acceleration at 13 frequencies (1-16 Hz) at magnitudes from 0.1 to 4.0 ms(-2) r.m.s. The frequency-dependence of their equivalent comfort contours depended on the magnitude of vibration, but was less dependent on the magnitude of dynamic force than the magnitude of acceleration, consistent with the biodynamic non-linearity of the body causing some of the magnitude-dependence of equivalent comfort contours. There were significant associations between the biodynamic responses and subjective responses at all frequencies in the range 1-16 Hz. Practitioner Summary: Vertical seat vibration causes discomfort in many forms of transport. This study provides the frequency-dependence of vibration discomfort over a range of vibration magnitudes and shows how the frequency weightings in the current standards can be improved.

  19. The Rachel Carson Letters and the Making of Silent Spring

    Directory of Open Access Journals (Sweden)

    John Paull

    2013-06-01

    Full Text Available Environment, conservation, green, and kindred movements look back to Rachel Carson’s 1962 book Silent Spring as a milestone. The impact of the book, including on government, industry, and civil society, was immediate and substantial, and has been extensively described; however, the provenance of the book has been less thoroughly examined. Using Carson’s personal correspondence, this paper reveals that the primary source for Carson’s book was the extensive evidence and contacts compiled by two biodynamic farmers, Marjorie Spock and Mary T. Richards, of Long Island, New York. Their evidence was compiled for a suite of legal actions (1957-1960 against the U.S. Government and that contested the aerial spraying of dichlorodiphenyltrichloroethane (DDT. During Rudolf Steiner’s lifetime, Spock and Richards both studied at Steiner’s Goetheanum, the headquarters of Anthroposophy, located in Dornach, Switzerland. Spock and Richards were prominent U.S. anthroposophists, and established a biodynamic farm under the tutelage of the leading biodynamics exponent of the time, Dr. Ehrenfried Pfeiffer. When their property was under threat from a government program of DDT spraying, they brought their case, eventually lost it, in the process spent US$100,000, and compiled the evidence that they then shared with Carson, who used it, and their extensive contacts and the trial transcripts, as the primary input for Silent Spring. Carson attributed to Spock, Richards, and Pfeiffer, no credit whatsoever in her book. As a consequence, the organics movement has not received the recognition, that is its due, as the primary impulse for Silent Spring, and it is, itself, unaware of this provenance.

  20. Landschaftsentwicklung auf den Bauckhöfen (Niedersachsen)

    OpenAIRE

    Elsen, Thomas van; Franz, Gregor

    2007-01-01

    The study deals with the historical development and today’s appearance of landscape on the three bio-dynamic Bauck-Farms in the Lüneburger Heide-region. In the past 50 years responsible people in charge on the farms conducted a determined rural devel-opment on the farmland. The results of these efforts and the motives of six persons in charge were investigated. In a territory where hedgerows are not very common, 49 hedges where planted within arable fields and the forests were changed from pi...

  1. Osteobiology: newest bone organ topics and the platelet-rich plasma treatment.

    Directory of Open Access Journals (Sweden)

    Ananias García Cardona

    2007-11-01

    Full Text Available The bone is a dynamic tissue taht provides mechanical support, physical protection, storage site for minerals, and enables genesis movement. The bone biology (osteobiology is regulated by the balance betqeen osteoblastic formation and osteoclatic resorption. the skeletal bone homeostasis is influenced by components of the bone marrow organ, neuroendocrine system and hemato-inmmune system. The purpose of this review is to describe the biodynamic of the bone organ, and actual terapeutics with platelet-rich plasma in guide bone regeneration, a co-surgical method employed to increase the quantity and quality of the bone.

  2. Exploratory Research and Development Fund, FY 1990. Report on Lawrence Berkeley Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R&D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R&D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiation biophysics.

  3. Exploratory Research and Development Fund, FY 1990

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiation biophysics.

  4. Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity

    Directory of Open Access Journals (Sweden)

    Tasneem Taj

    2014-12-01

    Full Text Available In the present investigation we have utilized the 3-arylsydnones 1a–c to couple two biodynamic moieties in amide derivatives 7–10. The 3-arylsydnones were brominated to 4-bromo-3-arylsydnones 2a–c which further were reacted with benzotriazole/benzothiazolin-2-thione/morpholine/diphenylamine to the corresponding final compounds. The structures of the amide derivatives were confirmed by the spectral (IR, 1H NMR and Mass and analytical data. Further, these were subjected to the antitubercular activity against Mycobacterium tuberculae (H37Rv. The morpholine 7a–c and benzotriazole 8a–c derivatives have exhibited good inhibition.

  5. The Trofobiose Theory and organic agriculture: the active mobilization of nutrients and the use of rock powder as a tool for sustainability

    OpenAIRE

    POLITO, Wagner L.

    2006-01-01

    The primary objective of the present paper is to link some relevant concepts on the use of ecological agricultural practices to the production of food crops. In a special topic the Trofobiose Theory, as well as the principle of Active Dissolution of Rocks are considered as important tools in improving the sustainability of Organic, Biodynamic and Process Agricultures.O objetivo principal deste trabalho é estabelecer relação entre alguns conceitos relevantes sobre o uso de práticas agro-ecológ...

  6. CHALCONE AS A VERSATILE MOIETY FOR DIVERSE PHARMACOLOGICAL ACTIVITIES

    Directory of Open Access Journals (Sweden)

    Hatish Prashar*, Anshul Chawla, Anil Kumar Sharma and Rajeev Kharb

    2012-07-01

    Full Text Available Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim of this review is to summarize chalcones and their diverse pharmacological activities like anticancer, antimicrobial, analgesic and antiviral activities etc.

  7. Rehabilitation treatment after operation for lower back interveterbral disc protrusion%腰椎间盘突出症术后的康复治疗

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Background: Most operation treating the lower back interveterbral disc protrusion apply posterior vertebral lamina fenestration an half vertebral lamina removing or vertebral lamina removing, the vertebral tube was opened and the nucleus pulposus was removed, while all these methods caused weakened spinal column stability. Satisfactory treating results may be gained with the horizontal and vertical chiseling and reserved replanting of vertebral lamina designed according to biodynamic principles. Objective: To discuss the treating effects of reserved replanting of vertebral lamina and rehabilitation treatment after operation in lower back intervertebral disc protrusion. Unit:Second People's Hospital of Ningxia.

  8. Organic Farming in Austria

    OpenAIRE

    Vogl, C.R.; Heß, J

    1999-01-01

    During the present decade, Austria has experienced a dramatic increase in organic farming among those countries that comprise the European Union (EU). For example, in 1992, approximately 2,000 farms were practicing organic, ecological, or biodynamic farming methodes. By 1997 the number of certified organic farms plus those in transition from conventional farming had increased 10-fold to some 20,000 farms. This represents almost 9% of the total farms in Austria and an area of 345,375 ha, or 10...

  9. Bioaccumulation of arsenic and silver by the caddisfly larvae Hydropsyche siltalai and H. pellucidula

    DEFF Research Database (Denmark)

    Awrahman, Zmnako; Rainbow, Philip S; Smith, Brian D

    2015-01-01

    Biodynamic modeling was used to investigate the uptake and bioaccumulation of arsenic and silver from water and food by two Hydropsychid caddisfly larvae: Hydropsyche siltalai and Hydropsyche pellucidula. Radiotracer techniques determined the uptake rate constants of arsenic and silver from water...... solution were significantly lower than those of As and Ag assimilated from ingested food in both species. Experimentally derived ku and ke values were then used to predict As and Ag tissue concentrations in hydropsychids collected from 13 UK sites, including metal-contaminated streams in Cornwall. Arsenic...

  10. Efficiency of Reflex Therapy in Complex Treatment of Circulatory Disturbances in Vertebrobasilar System

    Directory of Open Access Journals (Sweden)

    Goydenko V. S.

    2016-12-01

    Full Text Available The article deals with a complex examination and treatment of 198 patients (142 women and 56 men with circulatory disturbances in vertebrobasilar. Mean age of patients was 53.8±7.1 years. Reflex therapy including reflex therapy and biodynamic backbone correction was shown to increase the efficiency of complex therapy, allows to effect different chains of the developed pathological system, the fact confirmed by the dynamics of neurologic syndromes and dynamics of cerebrovascular reactivity at transcranial Doppler sonography.

  11. 生物动力学:一篇精短的面向实践的介绍

    Institute of Scientific and Technical Information of China (English)

    艾伦弗里德·法伊; 尚洁澄

    2009-01-01

    @@ 生物动力农耕与园艺倡导代表了什么 生物动力农耕及园艺方法(Biodynamic Farming and Gardening Method)是在晚年的鲁道夫·斯坦纳(Rudolf Steiner)--一位因其称为人智学(Anthriposophy),即人类的智慧(wisdom of man)的世界观而闻名的哲学家--所给出的建议和传授的基础之上,自1922年起产生和发展而来的.

  12. Bone and muscle structure and quality preserved by active versus passive muscle exercise on a new stepper device in 21 days tail-suspended rats.

    Science.gov (United States)

    Sun, L W; Blottner, D; Luan, H Q; Salanova, M; Wang, C; Niu, H J; Felsenberg, D; Fan, Y B

    2013-06-01

    Human performance in microgravity is characterized by reversed skeletal muscle actions in terms of active vs. passive mode contractions of agonist/antagonist groups that may challenge principal biodynamics (biomechanical forces translated from muscle to bone) of the skeletal muscle-bone unit. We investigated active vs. passive muscle motions of the unloaded hindlimb skeletal muscle-bone unit in the 21 days tail-suspended (TS) rat using a newly designed stepper exercise device. The regimen included both active mode motions (TSA) and passive mode motions (TSP). A TS-only group and a normal cage group (CON) served as positive or negative controls. The muscle and bone decrements observed in TS-only group were not seen in the other groups except TSP. Active mode motions supported femur and tibia bone quality (5% BMD, 10% microtrabecular BV/TV, Tb.Th., Tb.N. parameters), whole soleus muscle/myofiber size and type II distribution, 20% increased sarcolemma NOS1 immunosignals vs. CON, with 25% more hybrid fiber formation (remodeling sign) for all TS groups. We propose a new custom-made stepper device to be used in the TS rat model that allows for detailed investigations of the unique biodynamic properties of the muscle-bone unit during resistive-load exercise countermeasure trials on the ground or in microgravity.

  13. Vibration Analysis and Human Comfort Evaluation of Steel-Concrete Composite Footbridges Based on the Modelling of the PedestrianStructure Dynamic Interaction Effect

    Directory of Open Access Journals (Sweden)

    J.G. Santos da Silva

    2016-11-01

    Full Text Available This work aims the development of an analysis methodology to investigate the dynamic behaviour of steelconcrete composite footbridges. The composite footbridge dynamic response is analysed based on two different strategies. Firstly, the traditional simulation of human walking, without consideration of the pedestrianfootbridge dynamic interaction effect is considered. On the other hand, the effect of the dynamics of the pedestrians while crossing footbridges in crowd situations is analysed and the pedestrian-footbridge dynamic interaction, based on the use of biodynamic models is investigated using a second strategy. The investigated structural system corresponds to an existing pedestrian footbridge built on Ayrton Senna Av. in the city of Rio de Janeiro/RJ, Brazil, with a central span of 68.6m. The footbridge dynamic response was obtained and compared to the limiting values proposed by several authors and design standards. The results indicate that the biodynamic loading models lead to peak accelerations values lower than those produced by the traditional methods. These results provided evidence that the pedestrian-structure dynamic interaction effect should be considered when composite footbridges are subjected to flow of pedestrians.

  14. Contribution of aqueous and dietary uptakes to lead (Pb) bioaccumulation in Gammarus pulex: From multipathway modeling to in situ validation.

    Science.gov (United States)

    Hadji, Rym; Urien, Nastassia; Uher, Emmanuelle; Fechner, Lise C; Lebrun, Jérémie D

    2016-07-01

    Although dynamic approaches are nowadays used increasingly to describe metal bioaccumulation in aquatic organisms, the validation of such laboratory-derived modeling is rarely assessed under environmental conditions. Furthermore, information on bioaccumulation kinetics of Pb and the significance of its uptake by dietary route is scarce in freshwater species. This study aims at modeling aqueous and dietary uptakes of Pb in the litter-degrader Gammarus pulex and assessing the predictive quality of multipathway modeling from in situ bioaccumulation data. In microcosms, G. pulex were exposed to environmentally realistic concentrations of Pb (from 0.1 to 10µg/L) in the presence of Pb-contaminated poplar leaves, which were enclosed or not in a net to distinguish aqueous and dietary uptakes. Results show that water and food both constitute contamination sources for gammarids. Establishing biodynamic parameters involved in Pb aqueous and dietary uptake and elimination rates enabled to construct a multipathway model to describe Pb bioaccumulation in gammarids. This laboratory-derived model successfully predicted bioaccumulation measured in native populations of G. pulex collected in situ when local litter was used as dietary exposure source. This study demonstrates not only the suitable applicability of biodynamic parameters for predicting Pb bioaccumulation but also the necessity of taking dietary uptake into account for a better interpretation of the gammarids' contamination in natural conditions.

  15. Occupant Protection during Orion Crew Exploration Vehicle Landings

    Science.gov (United States)

    Gernhardt, Michael L.; Jones, J. A.; Granderson, B. K.; Somers, J. T.

    2009-01-01

    The constellation program is evaluating current vehicle design capabilities for nominal water landings and contingency land landings of the Orion Crew Exploration vehicle. The Orion Landing Strategy tiger team was formed to lead the technical effort for which associated activities include the current vehicle design, susceptibility to roll control and tip over, reviewing methods for assessing occupant injury during ascent / aborts /landings, developing an alternate seat/attenuation design solution which improves occupant protection and operability, and testing the seat/attenuation system designs to ensure valid results. The EVA physiology, systems and Performance (EPSP) project is leading the effort under the authority of the Tiger Team Steering committee to develop, verify, validate and accredit biodynamics models using a variety of crash and injury databases including NASCAR, Indy Car and military aircraft. The validated biodynamics models will be used by the Constellation program to evaluate a variety of vehicle, seat and restraint designs in the context of multiple nominal and off-nominal landing scenarios. The models will be used in conjunction with Acceptable Injury Risk definitions to provide new occupant protection requirements for the Constellation Program.

  16. ECOLOGICAL APPROACHES IN THE ORGANIC AGRICULTURAL SYSTEM

    Directory of Open Access Journals (Sweden)

    Veselka Vlahova

    2015-09-01

    Full Text Available The permaculture includes landscape shaping, terrace formation, establishment of raised planes and hilly beds. Sepp Holzer’s permaculture has been practices since 1962, having its followers in Columbia, Thailand, Brazil, the USA and Scotland, etc. Important specifics of the Fukuoka method consists of the requirement that the agricultural farm is close to nature, without any attempts to conquer or improve it, whence the method’s name “natural”, i.e. real or natural. In his book entitled “The One-Straw Revolution” the author examines the issues of natural agriculture. The Biodynamic French Intensive method of vegetable gardening combines two gardening traditions: biodynamics, created in the 1920s by Rudolph Steiner, and French intensive gardening, a method practiced by 19th century farmers on the outskirts of Paris. British horticulturist Alan Chadwick bought these methods to the United States in the 1960s and coined the term biointensive. This style of organic gardening focuses on sustainable, high productivity using minimal space.

  17. Practices to identify and preclude adverse Aircraft-and-Rotorcraft-Pilot Couplings - A design perspective

    Science.gov (United States)

    Pavel, Marilena D.; Masarati, Pierangelo; Gennaretti, Massimo; Jump, Michael; Zaichik, Larisa; Dang-Vu, Binh; Lu, Linghai; Yilmaz, Deniz; Quaranta, Giuseppe; Ionita, Achim; Serafini, Jacopo

    2015-07-01

    Understanding, predicting and supressing the inadvertent aircraft oscillations caused by Aircraft/Rotorcraft Pilot Couplings (A/RPC) is a challenging problem for designers. These are potential instabilities that arise from the effort of controlling aircraft with high response actuation systems. The present paper reviews, updates and discusses desirable practices to be used during the design process for unmasking A/RPC phenomena. These practices are stemming from the European Commission project ARISTOTEL Aircraft and Rotorcraft Pilot Couplings - Tools and Techniques for Alleviation and Detection (2010-2013) and are mainly related to aerodynamic and structural modelling of the aircraft/rotorcraft, pilot modelling and A/RPC prediction criteria. The paper proposes new methodologies for precluding adverse A/RPCs events taking into account the aeroelasticity of the structure and pilot biodynamic interaction. It is demonstrated that high-frequency accelerations due to structural elasticity cause negative effects on pilot control, since they lead to involuntary body and limb-manipulator system displacements and interfere with pilot's deliberate control activity (biodynamic interaction) and, finally, worsen handling quality ratings.

  18. Operator health risk evaluation of off-highway dump truck under shovel loading condition

    Institute of Scientific and Technical Information of China (English)

    申焱华; 许敏; 金纯; 高玉; 魏福林

    2015-01-01

    To evaluate the operator health risk exposed to whole-body vibration (WBV) while the electric-shovel loads the ore on the truck body, the semi-truck mathematical model and 3-D virtual prototype were built to simulate the high shockwave of truck cab under the shovel loading. Discrete element method was utilized to accurately estimate the impacting force on the truck body. Based on the ISO 2631-5 criteria, theSed is about 0.56 MPa in both models, which means that the dump operators have a high probability of adverse health effects over long-term exposure to these vibrations. The 4-DOF operator model was built to investigate the biodynamic response of seated-human body exposed to WBV in terms of the transmission of vibrations through the body. The results show that the response peak is in the frequency range of 4−6 Hz corresponding to the primary body resonant frequency.

  19. “Don Juan-Fracture” as a Hint to Aortic Isthmus Rupture

    Directory of Open Access Journals (Sweden)

    Sirilak Suksompong

    2014-01-01

    Full Text Available We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called “Don-Juan fracture,” and aortic rupture at the site of ligamentum arteriosum are discussed.

  20. Modeling of movements in sports training

    Directory of Open Access Journals (Sweden)

    Kashuba V.A.

    2010-08-01

    Full Text Available Aggregate data are expounded about methodical approaches at the modeling of technique of motor actions in sport. Practical material is presented on questions of design and perfection of technique of motor actions on the example of different types of sport. The model of technique of running step is offered on a line in short-track. A cross-correlation analysis between resulting speed of general centre-of-mass body of sportsmen and biomechanics descriptions exposed six important indexes. These indexes are plugged in a statistical model at run on a line. It is set that on the initial stages of preparation of sportsmen it is necessary to take into account the biokinematics and biodynamic structure of technique of motive actions.

  1. The Mathematical Model of the Interaction among Raw Milk Bacteria%原料奶中细菌间相互作用的数学模型

    Institute of Scientific and Technical Information of China (English)

    李冬梅; 赵兵; 王树忠

    2012-01-01

    利用微分生物动力学理论分析原料奶中细菌生态演变的过程,建立了在温度影响下原料奶中乳酸菌和酵母菌相互作用的数学模型,并给出模型的平衡点稳定性充分条件,从而确定了牛奶变质的临界条件.%This paper analyzes the ecological evolution of bacteria in raw milk by the differential biodynamic theory. It estabilishes the model of the interaction between the lactobacillus and yeast in raw milk under the influence of temperature. The sufficient conditions for stability of the model equilibrium is put out, and the critical conditions of milk deterioration has been identified.

  2. Evaluation of vermicompost maturity using scanning electron microscopy and paper chromatography analysis.

    Science.gov (United States)

    Senthil Kumar, D; Satheesh Kumar, P; Rajendran, N M; Uthaya Kumar, V; Anbuganapathi, G

    2014-04-02

    Vermicompost was produced from flower waste inoculated with biofertilizers using the earthworm Eisenia fetida. Principal component analysis (PCA) and cluster analysis (CA) were carried out on the basis of physicochemical parameters of vermicomposted samples. From the results of the PCA and CA, it was possible to classify two different groups of vermicompost samples in the following categories: E2 and E5; and E1, E3, E4, and control. Scanning electron microscopy and biodynamic circular paper chromatography analysis were used to investigate the changes in surface morphology and functional groups in the control and vermicompost products. SEM analysis of E1-E5 shows more fragment and pores than the control. Chromatographic analysis of vermicompost indicated the mature condition of the compost materials.

  3. "Don juan-fracture" as a hint to aortic isthmus rupture.

    Science.gov (United States)

    Suksompong, Sirilak; von Bormann, Benno

    2014-01-01

    We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called "Don-Juan fracture," and aortic rupture at the site of ligamentum arteriosum are discussed.

  4. “Don Juan-Fracture” as a Hint to Aortic Isthmus Rupture

    Science.gov (United States)

    Suksompong, Sirilak; von Bormann, Benno

    2014-01-01

    We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called “Don-Juan fracture,” and aortic rupture at the site of ligamentum arteriosum are discussed. PMID:25478249

  5. Prosthesis-user-in-the-loop: user-centered design parameters and visual simulation.

    Science.gov (United States)

    Christ, O; Wojtusch, J; Beckerle, P; Wolff, K; Vogt, J; von Stryk, O; Rinderknecht, S

    2012-01-01

    After an amputation, processes of change in the body image as well as a change in body scheme have direct influences on the quality of living in every patient. Within this paper, a paradigm of experimental induced body illusion (the Rubber Hand Illusion, RHI) is integrated in a prosthetic hardware simulator concept. This concept combines biodynamical and visual feedback to enhance the quality of rehabilitation and to integrate patients' needs into the development of prostheses aiming on user-centered solutions. Therefore, user-centered design parameters are deducted. Furthermore, the basic concept of the visual simulation is presented and a possibility for its implementation is given. Finally, issues and conclusions for future work are described.

  6. Motility Contrast Imaging and Tissue Dynamics Spectroscopy

    Science.gov (United States)

    Nolte, David D.; An, Ran; Turek, John

    Motion is the defining physiological characteristic of living matter. If we are interested in how things function, then the way they move is most informative. Motion provides an endogenous and functional suite of biomarkers that are sensitive to subtle changes that occur under applied pharmacological doses or cellular stresses. This chapter reviews the application of biodynamic imaging to measure cellular dynamics in three-dimensional tissue culture for drug screening applications. Nanoscale and microscale motions are detected through statistical fluctuations in dynamic speckle across an ensemble of cells within each resolution voxel. Tissue dynamics spectroscopy generates drug-response spectrograms that serve as phenotypic fingerprints of drug action and can differentiate responses from heterogeneous regions of tumor tissue.

  7. Dynamics and Control of Humanoid Robots: A Geometrical Approach

    CERN Document Server

    Ivancevic, Vladimir G

    2011-01-01

    his paper reviews modern geometrical dynamics and control of humanoid robots. This general Lagrangian and Hamiltonian formalism starts with a proper definition of humanoid's configuration manifold, which is a set of all robot's active joint angles. Based on the `covariant force law', the general humanoid's dynamics and control are developed. Autonomous Lagrangian dynamics is formulated on the associated `humanoid velocity phase space', while autonomous Hamiltonian dynamics is formulated on the associated `humanoid momentum phase space'. Neural-like hierarchical humanoid control naturally follows this geometrical prescription. This purely rotational and autonomous dynamics and control is then generalized into the framework of modern non-autonomous biomechanics, defining the Hamiltonian fitness function. The paper concludes with several simulation examples. Keywords: Humanoid robots, Lagrangian and Hamiltonian formalisms, neural-like humanoid control, time-dependent biodynamics

  8. Unobtrusive behavioral and activity-related multimodal biometrics: The ACTIBIO Authentication concept.

    Science.gov (United States)

    Drosou, A; Ioannidis, D; Moustakas, K; Tzovaras, D

    2011-03-01

    Unobtrusive Authentication Using ACTIvity-Related and Soft BIOmetrics (ACTIBIO) is an EU Specific Targeted Research Project (STREP) where new types of biometrics are combined with state-of-the-art unobtrusive technologies in order to enhance security in a wide spectrum of applications. The project aims to develop a modular, robust, multimodal biometrics security authentication and monitoring system, which uses a biodynamic physiological profile, unique for each individual, and advancements of the state of the art in unobtrusive behavioral and other biometrics, such as face, gait recognition, and seat-based anthropometrics. Several shortcomings of existing biometric recognition systems are addressed within this project, which have helped in improving existing sensors, in developing new algorithms, and in designing applications, towards creating new, unobtrusive, biometric authentication procedures in security-sensitive, Ambient Intelligence environments. This paper presents the concept of the ACTIBIO project and describes its unobtrusive authentication demonstrator in a real scenario by focusing on the vision-based biometric recognition modalities.

  9. Molecular analysis of red wine yeast diversity in the Ribera del Duero D.O. (Spain) area.

    Science.gov (United States)

    Muñoz-Bernal, Eugenia; Rodríguez, María Esther; Benítez, Patricia; Fernández-Acero, Francisco Javier; Rebordinos, Laureana; Cantoral, Jesús Manuel

    2013-05-01

    Molecular characterization of wine yeast population during spontaneous fermentation in biodynamic wines from Ribera del Duero D.O. located at northern plateau of Spain has been carried out during two consecutive years. A total of 829 yeast strains were isolated from the samples and characterized by electrophoretic karyotype. The results show the presence of three population of yeast differentiated by their electrophoretic karyotypes, (1) non-Saccharomyces yeast dominant in the initial phase of the fermentations (NS); (2) Saccharomyces bayanus var uvarum detected mainly mid-way through the fermentation process at 20-25 °C; and (3) Saccharomyces cerevisiae which remained dominant until the end of the fermentation. This is the first study showing the population dynamic of S. bayanus var. uvarum in red wines produced in Ribera del Duero that could represent an important source of autochthonous wine yeasts with novel oenological properties.

  10. Simulation of Adaptive Seat Energy Absorber for Military Rotorcraft Crash Safety Enhancement

    Science.gov (United States)

    2014-04-01

    body biodynamic response. The stiffness and damping properties of the cervical spine are represented by k1 and c1, those of the thoracic spine by k2 and...the human body segments. Stiffness Damping Source Cervical spine (k1, c1) 310.0(kN/m) 400.0(N·s/m) (4) Thoracic spine (k2, c2) 183.0(kN/m... Flexion (N·m/rad): 53.2·Exp(0.98×θ2)-53.2 100.0 (N·m·s/rad) (6) Knee joint (k6, c6) Extension (N·m/rad): 90.5·Exp(2.0×θ3)−90.5 Flexion (N·m/rad

  11. 股骨近端骨折应用髁动力加压板在术后早期非负重功能训练中的作用%The function of the dynamic condylar screw in the early post operational non loading functional exercises for the proximal fracture of femur

    Institute of Scientific and Technical Information of China (English)

    茅治湘; 王鸥; 王全明

    2002-01-01

    @@ Background: Recently, more and more high energy injuries appeared, the proximal fracture of femur was no longer the simple fracture of btween femur tuberosity or below femur tuberosity.It is often accompanied with fracture of the upper femur.For biodynamic and anatomical reasons, such fractures are difficult to deal with,there is often great pressing stress in the inner corner of the neck of the femur, which caused great extending stress in the outer surface.Such fractures are unsteady for any of such stresses would cause the inner immobilization to fail,while to apply the dynamic condylar screw(DCS) on such fractures may got satisfactory results and it provided favorable conditions for the early post operational non loading walking exercises. Objective: To discuss the treating value of DCS in the proximal fracture of the femur.

  12. 抗冲地砖对立姿舰员的冲击防护效能分析%Performance of an Elastic Polymer Foam Cushion in Attenuating Responses of Shipboard Standing-men to Vertical Ship Shock

    Institute of Scientific and Technical Information of China (English)

    吴静波; 谌勇; 李兆俊; 黄建松; 华宏星

    2011-01-01

    Protection of shipboard personnel from shock events induced by underwater explosion is very interesting to ship designers. In this study, the potential attenuation performance of an elastic polymer foam cushion inserted between standing-man and ship deck is investigated theoretically. An 8-DOF nonlinear lumped-parameter model is used to predict the standing-man's biodynam-ic responses and injury potential. The cushion is modeled by a chain of masses separated by nonlinear springs and dampers in parallel to simulate the micro inertia, stiffness and rate-dependent effects exhibited by common polymer cellular materials. Two variables, kickoff speed (KS) ratio and deck reaction force (DRF) ratio corresponding to two types of typical injury potential of standing-men, are defined as evaluation parameters. The influence of critical buckling force level, material rate dependent effect as well as other design factors on the attenuation performance of the foam cushion is discussed in detail. Some general design rules are also presented.%利用八自由度集总参数模型描述立姿舰员的生物动力学响应并预测其受损趋势,应用非线性质量-弹簧及阻尼模型模拟多孔结构的微惯性、刚度及粘性效应.定义最大抛离速度比及最大甲板反力比评价抗冲地砖的防护效果,讨论了抗冲地砖的无量纲临界屈曲力水平、粘性效应对其人员防护效果的影响,给出了人员抗冲用抗冲地砖应遵循的一般设计原则.

  13. Application of Anaerobic Digestion Model No .1 combining hydrodynamics in UASB reactor%结合水动力学的厌氧消化1号模型在UASB反应器中的应用

    Institute of Scientific and Technical Information of China (English)

    何佳; 霍颖超; 张泽; 穆杨; 曾建雄

    2014-01-01

    建立了新型的以厌氧消化1号模型为基础的对流扩散模型来模拟升流式厌氧污泥床反应器,在此模型中同时考虑了水动力学及生化动力学。模型涉及的偏微分方程借助中心有限差分法在M atlab中编程进行求解。示踪剂实验与两组有机负荷冲击实验分别用于验证对流扩散模型的水动力学及生化动力学,结果显示模拟数据与实验数据能很好地吻合。此外,所建立的模型还能反映不同高度处的反应器状态,借助这个优势可以在反应器遭受异常情况时进行预警。%A novel Anaerobic Digestion Model No .1 based dispersive model was developed to simulate the upflow anaerobic sludge blanket reactor (UASB) ,in which both hydrodynamics and bio-dynamics were taken into account .The partial differential equations in the model was solved by finite difference method in Matlab . A tracer study and two loading-shock experiments were used to validate the reactor's hydrodynamics and bio-dynamics ,respectively .The simulated data match the experimental data very well . Besides ,the developed model can reflect the reactor's status at different heights ,w hich makes it possible to give early warnings in abnormal situations .

  14. Apparent mass of the human body in the vertical direction: Effect of a footrest and a steering wheel

    Science.gov (United States)

    Toward, M. G. R.; Griffin, M. J.

    2010-04-01

    The apparent mass of the seated human body influences the vibration transmitted through a car seat. The apparent mass of the body is known to be influenced by sitting posture but the influence of the position of the hands and the feet is not well understood. This study was designed to quantify the influence of steering wheel location and the position of a footrest on the vertical apparent mass of the human body. The influences of the forces applied by the hands to a steering wheel and by the feet to a footrest were also investigated. Twelve subjects were exposed to whole-body vertical random vibration (1.0 m s -2 rms over the frequency range 0.13-40.0 Hz) while supported by a rigid seat with a backrest reclined to 15°. The apparent mass of the body was measured with five horizontal positions and three vertical positions of a steering wheel and also with hands in the lap, and with five horizontal positions of a footrest. The influence of five forward forces (0, 50, 100, 150, 200 N) applied separately to the 'steering wheel' and the footrest were also investigated as well as a 'no backrest' condition. With their hands in their laps, subjects exhibited a resonance around 6.7 Hz, compared to 4.8 Hz when sitting upright with no backrest. In the same posture holding a steering wheel, the mass supported on the seat surface decreased and there was an additional resonance at 4 Hz. Moving the steering wheel away from the body reduced the apparent mass at the primary resonance frequency and increased the apparent mass around the 4 Hz resonance. As the feet moved forward, the mass supported on the seat surface decreased, indicating that the backrest and footrest supported a greater proportion of the subject weight. Applying force to either the steering wheel or the footrest reduced the apparent mass at resonance and decreased the mass supported on the seat surface. It is concluded that the positions and contact conditions of the hands and the feet affect the biodynamic

  15. Bioturbation delays attenuation of DDT by clean sediment cap but promotes sequestration by thin-layered activated carbon.

    Science.gov (United States)

    Lin, Diana; Cho, Yeo-Myoung; Werner, David; Luthy, Richard G

    2014-01-21

    The effects of bioturbation on the performance of attenuation by sediment deposition and activated carbon to reduce risks from DDT-contaminated sediment were assessed for DDT sediment-water flux, biouptake, and passive sampler (PE) uptake in microcosm experiments with a freshwater worm, Lumbriculus variegatus. A thin-layer of clean sediment (0.5 cm) did not reduce the DDT flux when bioturbation was present, while a thin (0.3 cm) AC cap was still capable of reducing the DDT flux by 94%. Bioturbation promoted AC sequestration by reducing the 28-day DDT biouptake (66%) and DDT uptake into PE (>99%) compared to controls. Bioturbation further promoted AC-sediment contact by mixing AC particles into underlying sediment layers, reducing PE uptake (55%) in sediment compared to the AC cap without bioturbation. To account for the observed effects from bioturbation, a mass transfer model together with a biodynamic model were developed to simulate DDT flux and biouptake, respectively, and models confirmed experimental results. Both experimental measurements and modeling predictions imply that thin-layer activated carbon placement on sediment is effective in reducing the risks from contaminated sediments in the presence of bioturbation, while natural attenuation process by clean sediment deposition may be delayed by bioturbation.

  16. Silica nanoparticle is a possible safe carrier for gene therapy

    Institute of Scientific and Technical Information of China (English)

    XUE Zhigang; DAI Heping; TANG Baisha; XIA Kun; XIA Jiahui; LIANG Desheng; LI Yumei; LONG Zhigao; PAN Qian; LIU Xionghao; WU Lingqian; ZHU Shaihong; CAI Fang

    2005-01-01

    In order to develop a safe and effective gene therapy carrier, some toxicological and biodynamical experiments were carried out on silica nanoparticles (SiNPs). First we prepared SiNPs with appropriate portions of cyclohexane, deionized water and ethyl silicate, and then transfected the modified SiNPs and GFP plasmid DNA complex into the HT1080 cells to test the effectiveness of transfection for gene therapy. At the same time, we injected the SiNPs into a number of mice through tail vein. Then we made the mice crossed to evaluate the acute, long-term and reproductive toxicity. In vivo distribution analysis and pathological examination were made on both adult mice and their offspring. SiNPs were uniform and had an average diameter of 40 nm, and the modified SiNPs carried exogenous DNA molecules into target cells and the transferred GFP fusion gene was effectively expressed in the cells. The SiNPs injected via tail vein were widely distributed in almost all of tissues, and the injected mice had the ability to reproduce normally. The in vivo and in vitro results of this study clearly show that SiNPs can be used as a safe and effective carrier for gene transfection and gene therapy.

  17. Unobtrusive Behavioral and Activity-Related Multimodal Biometrics: The ACTIBIO Authentication Concept

    Directory of Open Access Journals (Sweden)

    A. Drosou

    2011-01-01

    Full Text Available Unobtrusive Authentication Using ACTIvity-Related and Soft BIOmetrics (ACTIBIO is an EU Specific Targeted Research Project (STREP where new types of biometrics are combined with state-of-the-art unobtrusive technologies in order to enhance security in a wide spectrum of applications. The project aims to develop a modular, robust, multimodal biometrics security authentication and monitoring system, which uses a biodynamic physiological profile, unique for each individual, and advancements of the state of the art in unobtrusive behavioral and other biometrics, such as face, gait recognition, and seat-based anthropometrics. Several shortcomings of existing biometric recognition systems are addressed within this project, which have helped in improving existing sensors, in developing new algorithms, and in designing applications, towards creating new, unobtrusive, biometric authentication procedures in security-sensitive, Ambient Intelligence environments. This paper presents the concept of the ACTIBIO project and describes its unobtrusive authentication demonstrator in a real scenario by focusing on the vision-based biometric recognition modalities.

  18. Influence of industrial and alternative farming systems on contents of sugars, organic acids, total phenolic content, and the antioxidant activity of red beet (Beta vulgaris L. ssp. vulgaris Rote Kugel).

    Science.gov (United States)

    Bavec, Martina; Turinek, Matjaz; Grobelnik-Mlakar, Silva; Slatnar, Ana; Bavec, Franc

    2010-11-24

    The contents of sugars, organic acids, total phenolic content, and the antioxidant activity were quantified in the flesh of red beet from conventional (CON), integrated (INT), organic (ORG), biodynamic (BD), and control farming systems using established methods. Significant differences were measured for malic acid, total phenolic content (TPC), and total antioxidant activity, where malic acid content ranged from 2.39 g kg(-1) FW (control) to 1.63 g kg(-1) FW (CON, ORG, and INT). The highest TPC was measured in BD and control samples (0.677 and 0.672 mg GAE g(-1), respectively), and the lowest in CON samples (0.511 mg GAE g(-1)). Antioxidant activity was positively correlated with TPC (r2=0.6187) and ranged from 0.823 μM TE g(-1) FW to 1.270 μM TE g(-1) FW in CON and BD samples, respectively, whereas total sugar content ranged from 21.03 g kg(-1) FW (CON) to 31.58 g kg(-1) FW (BD). The importance of sugars, organic acids, phenols, and antioxidants for human health, as well as for plant resilience and health, gained from this explorative study, is discussed and put into perspective.

  19. Uptake dynamics of inorganic mercury and methylmercury by the earthworm Pheretima guillemi.

    Science.gov (United States)

    Dang, Fei; Zhao, Jie; Zhou, Dongmei

    2016-02-01

    Mercury uptake dynamics in the earthworm Pheretima guillemi, including the dissolved uptake rate constant (ku) from pore-water and assimilation efficiencies (AEs) from mercury-contaminated soil, was quantified in this study. Dissolved uptake rate constants were 0.087 and 0.553 L g(-1) d(-1) for inorganic mercury (IHg) and methylmercury (MeHg), respectively. Assimilation efficiency of IHg in field-contaminated soil was 7.2%, lower than 15.4% of spiked soil. In contrast, MeHg exhibited comparable AEs for both field-contaminated and spiked soil (82.4-87.2%). Within the framework of biodynamic model, we further modelled the exposure pathways (dissolved exposure vs soil ingestion) to source the accumulated mercury in Pheretima guillemi. The model showed that the relative importance of soil ingestion to mercury bioaccumulation depended largely on mercury partitioning coefficients (K(d)), and was also influenced by soil ingestion rate of earthworms. In the examined field-contaminated soil, almost (>99%) accumulated IHg and MeHg was predicted to derive from soil ingestion. Therefore, soil ingestion should be carefully considered when assessing mercury exposure risk to earthworms.

  20. Observations from a 4-year contamination study of a sample depth profile through Martian meteorite Nakhla.

    Science.gov (United States)

    Toporski, Jan; Steele, Andrew

    2007-04-01

    Morphological, compositional, and biological evidence indicates the presence of numerous well-developed microbial hyphae structures distributed within four different sample splits of the Nakhla meteorite obtained from the British Museum (allocation BM1913,25). By examining depth profiles of the sample splits over time, morphological changes displayed by the structures were documented, as well as changes in their distribution on the samples, observations that indicate growth, decay, and reproduction of individual microorganisms. Biological staining with DNA-specific molecular dyes followed by epifluorescence microscopy showed that the hyphae structures contain DNA. Our observations demonstrate the potential of microbial interaction with extraterrestrial materials, emphasize the need for rapid investigation of Mars return samples as well as any other returned or impactor-delivered extraterrestrial materials, and suggest the identification of appropriate storage conditions that should be followed immediately after samples retrieved from the field are received by a handling/curation facility. The observations are further relevant in planetary protection considerations as they demonstrate that microorganisms may endure and reproduce in extraterrestrial materials over long (at least 4 years) time spans. The combination of microscopy images coupled with compositional and molecular staining techniques is proposed as a valid method for detection of life forms in martian materials as a first-order assessment. Time-resolved in situ observations further allow observation of possible (bio)dynamics within the system.

  1. The Golden Spiral Flap: A New Flap Design that allows for Closure of Larger Wounds under Reduced Tension --How Studying Nature’ s Own Design Led to the Development of a New Surgical Technique

    Directory of Open Access Journals (Sweden)

    Sharad P. Paul

    2016-11-01

    Full Text Available This paper details the study of biodynamic excisional skin tension lines on the scalp, and the development of a new flap technique for closure of scalp wounds. Recently, a study by this author, on pigskin, replicated whorls by placing tissue under rapid stretch using saline tissue expanders, by re-creating rapid dermo-epidermal shear of skin – thereby concluding that the golden spiral pattern is nature’s own pattern for rapid expansion. Given the relationship between tissue expansion and stretch have been shown to cause deformation gradients that have both elastic and growth factors, the author set out to test the hypothesis that a golden spiral pattern therefore would be more efficient at closing wounds under less tension when compared to standard semicircular rotational flap patterns. The author conducted a series of experiments, both on pigskin (to first confirm the hypothesis, using a recently developed computerized tensiometer and later a clinical study. This paper presents a new random pivotal flap technique for skin closures on the head and neck: The Golden Spiral Flap. Biomechanics, planning and advantages of this new flap are described in this paper.

  2. Life sciences: Lawrence Berkeley Laboratory, 1988

    Energy Technology Data Exchange (ETDEWEB)

    1989-07-01

    Life Sciences Research at LBL has both a long history and a new visibility. The physics technologies pioneered in the days of Ernest O. Lawrence found almost immediate application in the medical research conducted by Ernest's brother, John Lawrence. And the tradition of nuclear medicine continues today, largely uninterrupted for more than 50 years. Until recently, though, life sciences research has been a secondary force at the Lawrence Berkeley Laboratory (LBL). Today, a true multi-program laboratory has emerged, in which the life sciences participate as a full partner. The LBL Human Genome Center is a contribution to the growing international effort to map the human genome. Its achievements represent LBL divisions, including Engineering, Materials and Chemical Sciences, and Information and Computing Sciences, along with Cell and Molecular Biology and Chemical Biodynamics. The Advanced Light Source Life Sciences Center will comprise not only beamlines and experimental end stations, but also supporting laboratories and office space for scientists from across the US. This effort reflects a confluence of scientific disciplines --- this time represented by individuals from the life sciences divisions and by engineers and physicists associated with the Advanced Light Source project. And finally, this report itself, the first summarizing the efforts of all four life sciences divisions, suggests a new spirit of cooperation. 30 figs.

  3. Human response to vibration stress in Japanese workers: lessons from our 35-year studies A narrative review.

    Science.gov (United States)

    Matoba, Tsunetaka

    2015-01-01

    The occupational uses with vibratory tools or vehicles provoked health disorders of users. We reviewed narratively our articles of 35 yr studies and their related literatures, and considered the pathophysiology of the hand-arm vibration disorders. Concerning the risk factors of health impairments in workers with vibratory tools, there are two conflicting schools of the researchers: The peripheral school emphasizes that vibration only makes predominant impairments on hands and arms, showing typically Raynaud's phenomenon in the fingers. In the systemic school, the health disorders are produced by combination with vibration, noise and working environment, namely vibratory work itself, leading to diversified symptoms and signs in relation to systemic impairments. Our 35 yr studies have evidently supported the systemic school, including disorders of the central and autonomic nervous systems. The genesis is vibratory work itself, including vibration, noise, cold working environment, ergonomic and biodynamic conditions, and emotional stress in work. Because the health disorders yield in the whole body, the following measures would contribute to the prevention of health impairments: the attenuation of vibration and noise generated form vibratory machines and the regulations on operating tool hours. In conclusion, this occupational disease results from systemic impairments due to long-term occupational work with vibratory tools.

  4. Bone structure and quality preserved by active versus passive muscle exercise in 21 days tail-suspended rats

    Science.gov (United States)

    Luan, Huiqin; Sun, Lian-wen; Fan, Yu-bo

    2012-07-01

    Humans in Space suffer from microgravity-induced attenuated bone strength that needs to be addressed by on-orbit exercise countermeasures. However, exercise prescriptions so far did not adequately counteract the bone loss of astronauts in spaceflight because even active muscle contractions were converted to passive mode during voluntary bouts. We tested our hypothesis in unloaded rat hind limb following twenty-one days of tail-suspension (TS) combined with exercise using a hind limb stepper device designed by our group. Female Sprague Dawley rats (250g b.wt.) were divided into four groups (n=5, each): TS-only (hind limb unloading), TS plus passive mode exercise (TSP) induced by mechanically-forced passive hind limb lifting, TS plus active mode exercise (TSA) entrained by plantar electrostimulation, and control (CON) group. Standard measures of bone (e.g., mineral density, trabecular microstructure, biomechanics and ash weight) were monitored. Results provided that the attenuated properties of unloaded hind limb bone in TS-rats were more effectively supported by active mode than by passive mode motions. We here propose a modified exercise regimen combined with spontaneous muscle contractions thereby considering the biodynamic demands of both muscle and bone during resistive-load exercise in microgravity. Keywords: rat, BMD, DXA, passive exercise, active exercise, bone loss, tail suspension, spaceflight analogue, exercise countermeasure.

  5. Biological uptake of polychlorinated biphenyls by Macoma balthica from sediment amended with activated carbon

    Science.gov (United States)

    McLeod, Pamela B.; van den Heuvel-Greve, Martine J.; Luoma, S.N.; Luthy, R.G.

    2007-01-01

    This work characterizes the efficacy of activated carbon amendment in reducing polychlorinated biphenyl (PCB) bioavailability to clams (Macoma balthica) from field-contaminated sediment (Hunters Point Naval Shipyard, San Francisco Bay, CA, USA) Test methods were developed for the use of clams to investigate the effects of sediment amendment on biological uptake. Sediment was mixed with activated carbon for one month. Bioaccumulation tests (28 d) were employed to assess the relationships between carbon dose and carbon particle size on observed reductions in clam biological uptake of PCBs. Extraction and cleanup protocols were developed for the clam tissue. Efficacy of activated carbon treatment was found to increase with both increasing carbon dose and decreasing carbon particle size. Average reductions in bioaccumulation of 22, 64, and 84% relative to untreated Hunters Point sediment were observed for carbon amendments of 0.34, 1.7, and 3.4%, respectively. Average bioaccumulation reductions of 41, 73, and 89% were observed for amendments (dose = 1.7% dry wt) with carbon particles of 180 to 250, 75 to 180, and 25 to 75 ??m, respectively, in diameter, indicating kinetic phenomena in these tests. Additionally, a biodynamic model quantifying clam PCB uptake from water and sediment as well as loss through elimination provided a good fit of experimental data. Model predictions suggest that the sediment ingestion route contributed 80 to 95% of the PCB burdens in the clams. ?? 2007 SETAC.

  6. The Role of Field Margins in Agro-biodiversity Management at the Farm Level

    Directory of Open Access Journals (Sweden)

    Concetta Vazzana

    2007-06-01

    Full Text Available The agroecosystem could be considered as a mosaic so large to involve fields with annual and perennial crops, pastures, spots of wildwood, semi-natural habitats, vegetation in the edges of fields. In the agroecosystem these ecological infrastructures have a positive effects on the crops because of the exchange among community of organisms, materials and energy. The aim of this research is to evaluate the effects of field margins on some biodiversity components (plant species and carabid beetles of four farms located in Val d’Orcia (Tuscany. We compared three types of field margins: 1. Cultivated margin strips; 2. Sown grass margin strips; 3. Wild margin strips with hedgerow. In a very simplified typology of farming system, like the one studied (Val d’Orcia, the presence of field margins (hedges, margin strips and semi-natural habitats associated with the boundary is very important for its ecological effects: it improves the planned biodiversity, gives habitat, refuge, food and corridors for the movement to the different species of organisms in the area. Applying the multivariate analysis to the experimental data, we can notice a positive effect of the presence of field margins on the trend of both components of biodiversity. This positive effect, which support the mechanisms of autoregulation of the agroecosystems, is very important especially for organic and biodynamic agriculture, where the use of pesticides is not allowed.

  7. Modeling of a seated human body exposed to vertical vibrations in various automotive postures.

    Science.gov (United States)

    Liang, Cho-Chung; Chiang, Chi-Feng

    2008-04-01

    Although much research has been devoted to constructing specific models or to measuring the response characteristics of seated subjects, investigations on a mathematical human model on a seat with a backrest to evaluate vehicular riding comfort have not yet attracted the same level of attention. For the responses of a seated body to vertical vibrations, mathematical models of the mechanisms must be at least two-dimensional in the sagittal plane. In describing the motions of a seated body, two multibody models representative of the automotive postures found in the literature were investigated, one with and the other without a backrest support. Both models were modified to suitably represent the different automotive postures with and without backrest supports, and validated by various experimental data from the published literature pertaining to the same postural conditions. On the basis of the analytical study and the experimental validation, the fourteen-degrees-of-freedom model proposed in this research was found to be best fitted to the test results; therefore, this model is recommended for studying the biodynamic responses of a seated human body exposed to vertical vibrations in various automotive postures.

  8. Predicting Partitioning and Diffusion Properties of Nonpolar Chemicals in Biotic Media and Passive Sampler Phases by GC × GC.

    Science.gov (United States)

    Nabi, Deedar; Arey, J Samuel

    2017-02-14

    The chemical parameters needed to explain and predict bioavailability, biodynamics, and baseline toxicity are not readily available for most nonpolar chemicals detected in the environment. Here, we demonstrate that comprehensive two-dimensional gas chromatography (GC × GC) retention times can be used to predict 26 relevant properties for nonpolar chemicals, specifically: partition coefficients for diverse biotic media and passive sampler phases; aquatic baseline toxicity; and relevant diffusion coefficients. The considered biotic and passive sampler phases include membrane and storage lipids, serum and muscle proteins, carbohydrates, algae, mussels, polydimethylsiloxane, polyethylene, polyoxymethylene, polyacrylate, polyurethane, and semipermeable membrane devices. GC × GC-based chemical property predictions are validated with a compilation of 1038 experimental property data collected from the literature. As an example application, we overlay a map of baseline toxicity to fathead minnows onto the separated analyte signal of a polychlorinated alkanes (chlorinated paraffins) technical mixture that contains 7820 congeners. In a second application, GC × GC-estimated properties are used to parametrize multiphase partitioning models for mammalian tissues and organs. In a third example, we estimate chemical depuration kinetics for mussels. Finally, we illustrate an approach to screen the GC × GC chromatogram for nonpolar chemicals of potentially high concern, defined based on their GC × GC-estimated biopartitioning properties, diffusion properties, and baseline toxicity.

  9. Assessment of field-related influences on polychlorinated biphenyl exposures and sorbent amendment using polychaete bioassays and passive sampler measurements

    Science.gov (United States)

    Janssen, E.M.; Oen, A.M.; Luoma, S.N.; Luthy, R.G.

    2011-01-01

    Field-related influences on polychlorinated biphenyl (PCB) exposure were evaluated by employing caged deposit-feeders, Neanthes arenaceodentata, along with polyoxymethylene (POM) samplers using parallel in situ and ex situ bioassays with homogenized untreated or activated carbon (AC) amended sediment. The AC amendment achieved a remedial efficiency in reducing bioaccumulation by 90% in the laboratory and by 44% in the field transplants. In situ measurements showed that PCB uptake by POM samplers was greater for POM placed in the surface sediment compared with the underlying AC amendment, suggesting that tidal exchange of surrounding material with similar PCB availability as untreated sediment was redeposited in the cages. Polychlorinated biphenyls bioaccumulation with caged polychaetes from untreated sediment was half as large under field conditions compared with laboratory conditions. A biodynamic model was used to confirm and quantify the different processes that could have influenced these results. Three factors appeared most influential in the bioassays: AC amendment significantly reduces bioavailability under laboratory and field conditions; sediment deposition within test cages in the field partially masks the remedial benefit of underlying AC-amended sediment; and deposit-feeders exhibit less PCB uptake from untreated sediment when feeding is reduced. Ex situ and in situ experiments inevitably show some differences that are associated with measurement methods and effects of the environment. Parallel ex situ and in situ bioassays, passive sampler measurements, and quantifying important processes with a model can tease apart these field influences. ?? 2010 SETAC.

  10. Tremor Reduction at the Palm of a Parkinson’s Patient Using Dynamic Vibration Absorber

    Directory of Open Access Journals (Sweden)

    Sarah Gebai

    2016-07-01

    Full Text Available Parkinson’s patients suffer from severe tremor due to an abnormality in their central oscillator. Medications used to decrease involuntary antagonistic muscles contraction can threaten their life. However, mechanical vibration absorbers can be used as an alternative treatment. The objective of this study is to provide a dynamic modeling of the human hand that describes the biodynamic response of Parkinson’s patients and to design an effective tuned vibration absorber able to suppress their pathological tremor. The hand is modeled as a three degrees-of-freedom (DOF system describing the flexion motion at the proximal joints on the horizontal plane. Resting tremor is modeled as dual harmonic excitation due to shoulder and elbow muscle activation operating at resonance frequencies. The performance of the single dynamic vibration absorber (DVA is studied when attached to the forearm and compared with the dual DVA tuned at both excitation frequencies. Equations of motion are derived and solved using the complex transfer function of the non-Lagrangian system. The absorber’s systems are designed as a stainless steel alloy cantilevered beam with an attached copper mass. The dual DVA was the most efficient absorber which reduces 98.3%–99.5%, 97.0%–97.3% and 97.4%–97.5% of the Parkinson’s tremor amplitude at the shoulder, elbow and wrist joint.

  11. The "Basqueness" of the Basques of Alava: a reappraisal from a multidisciplinary perspective.

    Science.gov (United States)

    Manzano, C; Orue, J M; de la Rúa, C

    1996-02-01

    The genetic and linguistic peculiarity of the Basque population is well known. Analysis of the studies published to date on the Basque population reveals that these studies refer basically to the provinces of Vizcaya and Labourd, both in the Northern part of the Basque Country. Multidisciplinary information indicates that the landscape differences of the Basque Country could have conditioned differential population biodynamics in the Atlantic and Mediterranean parts of the Basque area. In order to evaluate this possibility, this study focuses on the genetic constitution of the Basque population of Alava (in the South of the Basque Country) through the analysis of several red-cell systems. The data obtained in this genetic study and those from archaeology, linguistics, ethnography, and skeletal biology suggest that within the "Basque population" there may be at least two distinct groups: an "Atlantic" group and a "Mediterranean" one, divided mainly by the watershed. This geographical feature could have led to a greater genetic isolation of the Northern slopes, with the South more open to population contact. This is reflected nowadays in the different cline distribution detected for most systems in the Alava Basques in comparison with other Basque and Iberian Peninsula series studied to date.

  12. Evaluación de la composición corporal en pacientes con insuficiencia renal crónica Body composition assessment in patients with chronic renal failure

    Directory of Open Access Journals (Sweden)

    M. Cano

    2010-08-01

    Full Text Available Introducción: La evaluación de la composición corporal es de gran importancia en la pesquisa temprana de alteraciones en el estado nutricional por déficit o por exceso, sin embargo existen pocos métodos de campo confiables para este objetivo en pacientes con insuficiencia renal crónica (IRC. Objetivo: Evaluar la confiabilidad de estimaciones de composición corporal con distintos métodos en comparación con absorciometría de rayos X de doble energía (DEXA como método de referencia, en pacientes portadores de IRC sometidos a hemodiálisis crónica periódica. Pacientes y métodos: Se evaluó la composición corporal en 30 pacientes en hemodiálisis (46,9 ± 15,1 años (18-76; IMC 25,9 ± 5,7 kg/m² (18,1-41,5, observando la concordancia en el porcentaje de masa grasa (%MG entre sumatoria de 4 pliegues (SP; calibrador Lange® y bioimpedanciometría usando distintas ecuaciones (BIA; Biodynamics® 450 contra DEXA (Lunar DPX-L. Resultados: (X ± DE Según IMC, 3 individuos tenían bajo peso (10%, 14 normopeso (46,7%, 7 sobrepeso (23,3% y 6 obesidad (20%. El %MG con SP (30,7 ± 7,1% difirió significativamente de DEXA (27,3 ± 10,3%; p Introduction: Assessment of body composition is paramount in early assessment of nutritional status impairments due to excess or deficit. There are, however, few field reliable methods for this objective for patients with chronic renal failure (CRF.. Objective: To assess the reliability of the estimations of body composition by different methods as compared to dual energy X-ray absorptiometry (DEXA as the gold standard method in patients with CRF and on regular chronic haemodialysis. Patients and methods: We assessed body composition in 30 haemodialysis patients (46.9 ± 15.1 years (18-76; BMI 25.9 ± 5.7 kg/m² (18.1-41.5, observing agreement in the percentage of fat mass (%FM between the sum of the 4 folds (SP; calibrator Lange® and bioimpedantiometry by using different equations (BIA; Biodynamics® 450

  13. Effect of cysteine and humic acids on bioavailability of Ag from Ag nanoparticles to a freshwater snail

    Science.gov (United States)

    Luoma, Samuel N.; Tasha Stoiber,; Croteau, Marie-Noele; Isabelle Romer,; Ruth Merrifeild,; Lead, Jamie

    2016-01-01

    Metal-based engineered nanoparticles (NPs) will undergo transformations that will affect their bioavailability, toxicity and ecological risk when released to the environment, including interactions with dissolved organic material. The purpose of this paper is to determine how interactions with two different types of organic material affect the bioavailability of silver nanoparticles (AgNPs). Silver uptake rates by the pond snail Lymnaea stagnalis were determined after exposure to 25 nmol l-1 of Ag as PVP AgNPs, PEG AgNPs or AgNO3, in the presence of either Suwannee River humic acid or cysteine, a high-affinity thiol-rich organic ligand. Total uptake rate of Ag from the two NPs was either increased or not strongly affected in the presence of 1 – 10 mg 1-1 humic acid. Humic substances contain relatively few strong ligands for Ag explaining their limited effects on Ag uptake rate. In contrast, Ag uptake rate was substantially reduced by cysteine. Three components of uptake from the AgNPs were quantified in the presence of cysteine using a biodynamic modeling approach: uptake of dissolved Ag released by the AgNPs, uptake of a polymer or large (>3kD) Ag-cysteine complex and uptake of the nanoparticle itself. Addition of 1:1 Ag:cysteine reduced concentrations of dissolved Ag, which contributed to, but did not fully explain the reductions in uptake. A bioavailable Ag-cysteine complex (> 3kD) appeared to be the dominant avenue of uptake from both PVP AgNPs and PEG AgNPs in the presence of cysteine. Quantifying the different avenues of uptake sets the stage for studies to assess toxicity unique to NPs.

  14. Yield and economic performance of organic and conventional cotton-based farming systems--results from a field trial in India.

    Directory of Open Access Journals (Sweden)

    Dionys Forster

    Full Text Available The debate on the relative benefits of conventional and organic farming systems has in recent time gained significant interest. So far, global agricultural development has focused on increased productivity rather than on a holistic natural resource management for food security. Thus, developing more sustainable farming practices on a large scale is of utmost importance. However, information concerning the performance of farming systems under organic and conventional management in tropical and subtropical regions is scarce. This study presents agronomic and economic data from the conversion phase (2007-2010 of a farming systems comparison trial on a Vertisol soil in Madhya Pradesh, central India. A cotton-soybean-wheat crop rotation under biodynamic, organic and conventional (with and without Bt cotton management was investigated. We observed a significant yield gap between organic and conventional farming systems in the 1(st crop cycle (cycle 1: 2007-2008 for cotton (-29% and wheat (-27%, whereas in the 2(nd crop cycle (cycle 2: 2009-2010 cotton and wheat yields were similar in all farming systems due to lower yields in the conventional systems. In contrast, organic soybean (a nitrogen fixing leguminous plant yields were marginally lower than conventional yields (-1% in cycle 1, -11% in cycle 2. Averaged across all crops, conventional farming systems achieved significantly higher gross margins in cycle 1 (+29%, whereas in cycle 2 gross margins in organic farming systems were significantly higher (+25% due to lower variable production costs but similar yields. Soybean gross margin was significantly higher in the organic system (+11% across the four harvest years compared to the conventional systems. Our results suggest that organic soybean production is a viable option for smallholder farmers under the prevailing semi-arid conditions in India. Future research needs to elucidate the long-term productivity and profitability, particularly of cotton

  15. Vibration energy absorption in the whole-body system of a tractor operator

    Directory of Open Access Journals (Sweden)

    Jan Szczepaniak

    2014-06-01

    Full Text Available Many people are exposed to whole-body vibration (WBV in their occupational lives, especially drivers of vehicles such as tractor and trucks. The main categories of effects from WBV are perception degraded comfort interference with activities-impaired health and occurrence of motion sickness. Absorbed power is defined as the power dissipated in a mechanical system as a result of an applied force. The vibration-induced injuries or disorders in a substructure of the human system are primarily associated with the vibration power absorption distributed in that substructure. The vibration power absorbed by the exposed body is a measure that combines both the vibration hazard and the biodynamic response of the body. The article presents measurement method for determining vibration power dissipated in the human whole body system called Vibration Energy Absorption (VEA. The vibration power is calculated from the real part of the force-velocity cross-spectrum. The absorbed power in the frequency domain can be obtained from the cross-spectrum of the force and velocity. In the context of the vibration energy transferred to a seated human body, the real component reflects the energy dissipated in the biological structure per unit of time, whereas the imaginary component reflects the energy stored/released by the system. The seated human is modeled as a series/parallel 4-DOF dynamic models. After introduction of the excitation, the response in particular segments of the model can be analyzed. As an example, the vibration power dissipated in an operator has been determined as a function of the agricultural combination operating speed 1.39 – 4.16 ms[sup] -1 [/sup].

  16. Expression of the endocannabinoid system in fibroblasts and myofascial tissues.

    Science.gov (United States)

    McPartland, John M

    2008-04-01

    The endocannabinoid (eCB) system, like the better-known endorphin system, consists of cell membrane receptors, endogenous ligands and ligand-metabolizing enzymes. Two cannabinoid receptors are known: CB(1) is principally located in the nervous system, whereas CB(2) is primarily associated with the immune system. Two eCB ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are mimicked by cannabis plant compounds. The first purpose of this paper was to review the eCB system in detail, highlighting aspects of interest to bodyworkers, especially eCB modulation of pain and inflammation. Evidence suggests the eCB system may help resolve myofascial trigger points and relieve symptoms of fibromyalgia. However, expression of the eCB system in myofascial tissues has not been established. The second purpose of this paper was to investigate the eCB system in fibroblasts and other fascia-related cells. The investigation used a bioinformatics approach, obtaining microarray data via the GEO database (www.ncbi.nlm.nih.gov/geo/). GEO data mining revealed that fibroblasts, myofibroblasts, chondrocytes and synoviocytes expressed CB(1), CB(2) and eCB ligand-metabolizing enzymes. Fibroblast CB(1) levels nearly equalled levels expressed by adipocytes. CB(1) levels upregulated after exposure to inflammatory cytokines and equiaxial stretching of fibroblasts. The eCB system affects fibroblast remodeling through lipid rafts associated with focal adhesions and dampens cartilage destruction by decreasing fibroblast-secreted metalloproteinase enzymes. In conclusion, the eCB system helps shape biodynamic embryological development, diminishes nociception and pain, reduces inflammation in myofascial tissues and plays a role in fascial reorganization. Practitioners wield several tools that upregulate eCB activity, including myofascial manipulation, diet and lifestyle modifications, and pharmaceutical approaches.

  17. Yield and economic performance of organic and conventional cotton-based farming systems--results from a field trial in India.

    Science.gov (United States)

    Forster, Dionys; Andres, Christian; Verma, Rajeev; Zundel, Christine; Messmer, Monika M; Mäder, Paul

    2013-01-01

    The debate on the relative benefits of conventional and organic farming systems has in recent time gained significant interest. So far, global agricultural development has focused on increased productivity rather than on a holistic natural resource management for food security. Thus, developing more sustainable farming practices on a large scale is of utmost importance. However, information concerning the performance of farming systems under organic and conventional management in tropical and subtropical regions is scarce. This study presents agronomic and economic data from the conversion phase (2007-2010) of a farming systems comparison trial on a Vertisol soil in Madhya Pradesh, central India. A cotton-soybean-wheat crop rotation under biodynamic, organic and conventional (with and without Bt cotton) management was investigated. We observed a significant yield gap between organic and conventional farming systems in the 1(st) crop cycle (cycle 1: 2007-2008) for cotton (-29%) and wheat (-27%), whereas in the 2(nd) crop cycle (cycle 2: 2009-2010) cotton and wheat yields were similar in all farming systems due to lower yields in the conventional systems. In contrast, organic soybean (a nitrogen fixing leguminous plant) yields were marginally lower than conventional yields (-1% in cycle 1, -11% in cycle 2). Averaged across all crops, conventional farming systems achieved significantly higher gross margins in cycle 1 (+29%), whereas in cycle 2 gross margins in organic farming systems were significantly higher (+25%) due to lower variable production costs but similar yields. Soybean gross margin was significantly higher in the organic system (+11%) across the four harvest years compared to the conventional systems. Our results suggest that organic soybean production is a viable option for smallholder farmers under the prevailing semi-arid conditions in India. Future research needs to elucidate the long-term productivity and profitability, particularly of cotton and

  18. American palm ethnomedicine: A meta-analysis

    Directory of Open Access Journals (Sweden)

    Balslev Henrik

    2009-12-01

    Full Text Available Abstract Background Many recent papers have documented the phytochemical and pharmacological bases for the use of palms (Arecaceae in ethnomedicine. Early publications were based almost entirely on interviews that solicited local knowledge. More recently, ethnobotanically guided searches for new medicinal plants have proven more successful than random sampling for identifying plants that contain biodynamic ingredients. However, limited laboratory time and the high cost of clinical trials make it difficult to test all potential medicinal plants in the search for new drug candidates. The purpose of this study was to summarize and analyze previous studies on the medicinal uses of American palms in order to narrow down the search for new palm-derived medicines. Methods Relevant literature was surveyed and data was extracted and organized into medicinal use categories. We focused on more recent literature than that considered in a review published 25 years ago. We included phytochemical and pharmacological research that explored the importance of American palms in ethnomedicine. Results Of 730 species of American palms, we found evidence that 106 species had known medicinal uses, ranging from treatments for diabetes and leishmaniasis to prostatic hyperplasia. Thus, the number of American palm species with known uses had increased from 48 to 106 over the last quarter of a century. Furthermore, the pharmacological bases for many of the effects are now understood. Conclusions Palms are important in American ethnomedicine. Some, like Serenoa repens and Roystonea regia, are the sources of drugs that have been approved for medicinal uses. In contrast, recent ethnopharmacological studies suggested that many of the reported uses of several other palms do not appear to have a strong physiological basis. This study has provided a useful assessment of the ethnobotanical and pharmacological data available on palms.

  19. Development of a Dynamic Barrier Island (Sylt, Eastern North Sea) Based on High-Resolution Aerial Photographs and GIS

    Science.gov (United States)

    Dolch, T.; Hass, H. C.

    2004-12-01

    Wind and currents are the driving forces for the morphological development of coastlines and islands by giving them their shape, run and structure. This is especially true in highly dynamic areas such as the Wadden Sea in North-Western Europe. In this unique environment changes are continuous and distinct developments can be noticed within decades. The Island of Sylt, located in the Wadden Sea near the German-Danish border, is a sandy barrier island that protects the mainland against storm floods and waves. Thus, it experiences strong erosion (about 1 m coastal retreat per year). The North Atlantic Oscillation (NAO), that controls the atmospheric circulation over the North Sea, and northerly currents are the driving forces for the morphological development. Rising sea-level due to global change amplifies the erosion processes and forces people to protect the coastline (in this case beach nourishment). The Koenigshafen, a protected, semi-enclosed bay in the north of the Island of Sylt, can be regarded as representative for the study of many coastal processes that affect the island. In this case study, a long-term series of high resolution aerial photographs of the Koenigshafen (starting in 1936) shows the development of the survey area. Wind and currents affect not only the run of the coastline but also sediment composition and biodynamics in the bay. Looking at the hydrodynamics governing the bay, it should have mostly muddy sediments. Strong westerly winds, however, supply the bay with large amounts of sand from inland dunes and create sandy tidal flats. The long-term development of seagrass and mussel beds can also be retrieved from aerial photographs. In both cases a distinct decline in size can be noticed. Remote sensing and GIS techniques allow monitoring the conditions as well as to reconstruct the past development and to predict future developments.

  20. Agroforestry systems, nutrients in litter and microbial activity in soils cultivated with coffee at high altitude

    Directory of Open Access Journals (Sweden)

    Krystal de Alcantara Notaro

    2014-04-01

    Full Text Available Agroforestry systems are an alternative option for sustainable production management. These systems contain trees that absorb nutrients from deeper layers of the soil and leaf litter that help improve the soil quality of the rough terrain in high altitude areas, which are areas extremely susceptible to environmental degradation. The aim of this study was to characterize the stock and nutrients in litter, soil activity and the population of microorganisms in coffee (Coffea arabica L. plantations under high altitude agroforestry systems in the semi-arid region of the state of Pernambuco, Brazil. Samples were collected from the surface litter together with soil samples taken at two depths (0-10 and 10-20 cm from areas each subject to one of the following four treatments: agroforestry system (AS, native forest (NF, biodynamic system (BS and coffee control (CT.The coffee plantation had been abandoned for nearly 15 years and, although there had been no management or harvesting, still contained productive coffee plants. The accumulation of litter and mean nutrient content of the litter, the soil nutrient content, microbial biomass carbon, total carbon, total nitrogen, C/N ratio, basal respiration, microbial quotient, metabolic quotient and microbial populations (total bacteria, fluorescent bacteria group, total fungi and Trichoderma spp. were all analyzed. The systems thatwere exposed to human intervention (A and BS differed in their chemical attributes and contained higher levels of nutrients when compared to NF and CT. BS for coffee production at high altitude can be used as a sustainable alternative in the high altitude zones of the semi-arid region in Brazil, which is an area that is highly susceptible to environmental degradation.

  1. A SEASONAL INFLUENZA THEORY AND MATHEMATICAL MODEL INCORPORATING METEOROLOGICAL AND SOCIO- BEHAVIORAL FACTORS

    Institute of Scientific and Technical Information of China (English)

    Zhixiang ZHOU

    2009-01-01

    On the basis of a comprehensive literature review and data analysis of global influenza surveillance,a transmission theory based numerical model is developed to understand the causative factors of influenza seasonality and the biodynamical mechanisms of seasonal flu. The model is applied to simulate the seasonality and weekly activity of influenza in different areas across all continents and climate zones around the world. Model solution and the good matches between model output and actual influenza indexes affirm that influenza activity is highly auto-correlative and relies on determinants of a broad spectrum. Internal dynamic resonance; variations of meteorological elements (solar radiation,precipitation and dewpoint); socio-behavioral influences and herd immunity to circulating strains prove to be the critical explanatory thctors of the seasonality and weekly activity of influenza. In all climate regions,influenza activity is proportional to the exponential of the number of days with precipitation and to the negative exponential of quarter power of sunny hours. Influenza activity is a negative exponential function of dewpoint in temperate and arctic regions and an exponential function of the absolute deviation of dewpoint from its annual mean in the tropics. Epidemics of seasonal influenza could be deemed as the consequence of the dynamic resonance and interactions of determinants. Early interventions (such as opportune vaccination,prompt social distancing,and maintaining incidence well below a baseline) are key to the control and prevention of seasonal influenza. Moderate amount of sunlight exposure or Vitamin D supplementation during rainy and short-day photoperiod seasons,more outdoor activities,and appropriate indoor dewpoint deserve great attention in influenza prevention. To a considerable degree,the study reveals the mechanism of inlluenza seasonality,demonstrating a potential for influenza activity projection. The concept and algorithm can be explored

  2. Mechanisms of cell protection by adaptation to chronic and acute hypoxia: molecular biology and clinical practice.

    Science.gov (United States)

    Corbucci, G G; Marchi, A; Lettieri, B; Luongo, C

    2005-11-01

    , some specific aspects of the therapeutic management of critically ill patients are taken into consideration and discussed in relation to the cellular biodynamics.

  3. On the Health Risk of the Lumbar Spine due to Whole-Body VIBRATION—THEORETICAL Approach, Experimental Data and Evaluation of Whole-Body Vibration

    Science.gov (United States)

    Seidel, H.; Blüthner, R.; Hinz, B.; Schust, M.

    1998-08-01

    The guidance on the effects of vibration on health in standards for whole-body vibration (WBV) does not provide quantitative relationships between WBV and health risk. The paper aims at the elucidation of exposure-response relationships. An analysis of published data on the static and dynamic strength of vertebrae and bone, loaded with various frequencies under different conditions, provided the basis for a theoretical approach to evaluate repetitive loads on the lumbar spine (“internal loads”). The approach enabled the calculation of “equivalent”—with respect to cumulative fatigue failure—combinations of amplitudes and numbers of internal cyclic stress. In order to discover the relation between external peak accelerations at the seat and internal peak loads, biodynamic data of experiments (36 subjects, three somatotypes, two different postures—relaxed and bent forward; random WBV,aw, r.m.s. 1·4 ms-2, containing high transients) were used as input to a biomechanical model. Internal pressure changes were calculated using individual areas of vertebral endplates. The assessment of WBV was based on the quantitative relations between peak accelerations at the seat and pressures predicted for the disk L5/S1. For identical exposures clearly higher rates of pressure rise in the bent forward compared to the relaxed posture were predicted. The risk assessment for internal forces considered the combined internal static and dynamic loads, in relation to the predicted individual strength, and Miner's hypothesis. For exposure durations between 1 min and 8 h, energy equivalent vibration magnitudes (formula B.1, ISO 2631-1, 1997) and equivalent vibration magnitudes according to formula B.2 (time dependence over-energetic) were compared with equivalent combinations of upward peak accelerations and exposure durations according to predicted cumulative fatigue failures of lumbar vertebrae. Formula B.1 seems to underestimate the health risk caused by high magnitudes

  4. PCB-induced changes of a benthic community and expected ecosystem recovery following in situ sorbent amendment

    Science.gov (United States)

    Janssen, Elisabeth M.-L.; Thompson, Janet K.; Luoma, Samuel N.; Luthy, Richard G.

    2011-01-01

    The benthic community was analyzed to evaluate pollution-induced changes for the polychlorinated biphenyl (PCB)-contaminated site at Hunters Point (HP) relative to 30 reference sites in San Francisco Bay, California, USA. An analysis based on functional traits of feeding, reproduction, and position in the sediment shows that HP is depauperate in deposit feeders, subsurface carnivores, and species with no protective barrier. Sediment chemistry analysis shows that PCBs are the major risk drivers at HP (1,570 ppb) and that the reference sites contain very low levels of PCB contamination (9 ppb). Different feeding traits support the existence of direct pathways of exposure, which can be mechanistically linked to PCB bioaccumulation by biodynamic modeling. The model shows that the deposit feeder Neanthes arenaceodentata accumulates approximately 20 times more PCBs in its lipids than the facultative deposit feeder Macoma balthica and up to 130 times more than the filter feeder Mytilus edulis. The comparison of different exposure scenarios suggests that PCB tissue concentrations at HP are two orders of magnitude higher than at the reference sites. At full scale, in situ sorbent amendment with activated carbon may reduce PCB bioaccumulation at HP by up to 85 to 90% under favorable field and treatment conditions. The modeling framework further demonstrates that such expected remedial success corresponds to exposure conditions suggested as the cleanup goal for HP. However, concentrations remain slightly higher than at the reference sites. The present study demonstrates how the remedial success of a sorbent amendment, which lowers the PCB availability, can be compared to reference conditions and traditional cleanup goals, which are commonly based on bulk sediment concentrations.

  5. Segmental Dynamics of Forward Fall Arrests: System Identification Approach

    Science.gov (United States)

    Kim, Kyu-Jung; Ashton-Miller, James A.

    2009-01-01

    Background Fall-related injuries are multifaceted problems, necessitating thorough biodynamic simulation to identify critical biomechanical factors. Methods A 2-degree-of-freedom discrete impact model was constructed through system identification and validation processes using the experimental data to understand dynamic interactions of various biomechanical parameters in bimanual forward fall arrests. Findings The bimodal reaction force response from the identified models had small identification errors for the first and second force peaks less than 3.5% and high coherence between the measured and identified model responses (R2=0.95). Model validation with separate experimental data also demonstrated excellent validation accuracy and coherence, less than 7% errors and R2=0.87, respectively. The first force peak was usually greater than the second force peak and strongly correlated with the impact velocity of the upper extremity, while the second force peak was associated with the impact velocity of the body. The impact velocity of the upper extremity relative to the body could be a major risk factor to fall-related injuries as observed from model simulations that a 75% faster arm movement relative to the falling speed of the body alone could double the first force peak from soft landing, thereby readily exceeding the fracture strength of the distal radius. Interpretation Considering that the time-critical nature of falling often calls for a fast arm movement, the use of the upper extremity in forward fall arrests is not biomechanically justified unless sufficient reaction time and coordinated protective motion of the upper extremity are available. PMID:19250726

  6. Reconstruction the Function of Gluteus with Combined Latissimus Dorsal and Sacrospinalis Muscles and Artificial Tendon%背阔肌、骶棘肌和人工腱联合重建臀肌功能(附30例临床分析)

    Institute of Scientific and Technical Information of China (English)

    曾宪民; 左小宇; 陈建中; 陈永森

    1989-01-01

    This report describes a new method to reconstruct the function of gluteus with combined latissimus dorsal and sacrospinalis muscles and artificial tendon.Since 1985,30 cases aged 4-14 years have been operated on and all got satisfactory results except 3.The latissimus dorsal and sacrospinalis muscles were joined with the artificial tendon and fixed in a drilled hole located 2 cm below the greater trochanter and 5 cm below and on the back of the greater trochanter as a substitution for gluteal medium muscle and gluteal maximum muscle respectively.In comparison with the transferring of the abdominal external oblique muscle and musculus tensor fasciae latae,this procedure is more conformable to the biodynamic principles.After operation the stability of the hip can be improved.The authors consider this method is simple,safe with less trauma and less complications.%本文报告采用背闭肌、骶棘肌和人工腱联合重建臀肌功能30例,术后随访6个月~3年,其优良率达90%.介绍了此术的方法,并将其符合生物力学要求的几点因素与既往采用的腹外斜肌、骶棘肌与阔筋膜张肌及髂腰肌等代臀肌术式,在手术方法、疗效及并发症等方面作了比较.

  7. Optimal Control of Active Suspension in Consideration of Human Body Sitting Posture Model%考虑人体坐姿模型的汽车主动悬架最优控制

    Institute of Scientific and Technical Information of China (English)

    叶光湖; 盛云; 吴光强

    2013-01-01

    根据IS05982:2001 (E)推荐使用的人体坐姿低频振动模型,基于1/4汽车垂向振动模型,建立了车辆-人体振动系统的力学与数学模型.采用最优控制理论,设计了汽车主动悬架线性二次型调节控制器.在Matlab/Simulink环境下分别对被动悬架与主动悬架的性能进行仿真,时域和频域仿真结果对比表明,所建立的车辆-人体振动系统动力学模型能很好地反映人体振动特性,设计的主动悬架线性二次型调节控制器使汽车平顺性得到明显改善.%Based on the biodynamic model of the seated human body recommended by ISO 5982: 2001 (E) in low frequency vibration, and combined with the quarter automotive vertical vibration model, the mechanical and mathematical models of vehicle-human vibration system are established. Then, an active suspension with Linear Quadratic Regulator (LQR) controller is designed by applying the optimal control theory. The performance of the passive and active suspension systems is simulated in Matlab/Simulink and compared on frequency and time domain. The simulation results show that the vibration property of the human body can be well reflected by vehicle-human dynamics model, and the ride comfort of automobile with the active suspension with LQR is improved obviously.

  8. Sequence-based Analysis of the Vitis vinifera L. cv Cabernet Sauvignon Grape Must Mycobiome in Three South African Vineyards Employing Distinct Agronomic Systems

    Science.gov (United States)

    Setati, Mathabatha E.; Jacobson, Daniel; Bauer, Florian F.

    2015-01-01

    Recent microbiomic research of agricultural habitats has highlighted tremendous microbial biodiversity associated with such ecosystems. Data generated in vineyards have furthermore highlighted significant regional differences in vineyard biodiversity, hinting at the possibility that such differences might be responsible for regional differences in wine style and character, a hypothesis referred to as “microbial terroir.” The current study further contributes to this body of work by comparing the mycobiome associated with South African (SA) Cabernet Sauvignon grapes in three neighboring vineyards that employ different agronomic approaches, and comparing the outcome with similar data sets from Californian vineyards. The aim of this study was to fully characterize the mycobiomes associated with the grapes from these vineyards. The data revealed approximately 10 times more fungal diversity than what is typically retrieved from culture-based studies. The Biodynamic vineyard was found to harbor a more diverse fungal community (H = 2.6) than the conventional (H = 2.1) and integrated (H = 1.8) vineyards. The data show that ascomycota are the most abundant phylum in the three vineyards, with Aureobasidium pullulans and its close relative Kabatiella microsticta being the most dominant fungi. This is the first report to reveal a high incidence of K. microsticta in the grape/wine ecosystem. Different common wine yeast species, such as Metschnikowia pulcherrima and Starmerella bacillaris dominated the mycobiome in the three vineyards. The data show that the filamentous fungi are the most abundant community in grape must although they are not regarded as relevant during wine fermentation. Comparison of metagenomic datasets from the three SA vineyards and previously published data from Californian vineyards revealed only 25% of the fungi in the SA dataset was also present in the Californian dataset, with greater variation evident amongst ubiquitous epiphytic fungi. PMID

  9. The Smell of Selfless Love: Sharing Vulnerability with Bees in Alternative Apiculture

    Directory of Open Access Journals (Sweden)

    Green, Kelsey

    2014-05-01

    Full Text Available The sudden decline of bee pollinator populations worldwide has caused significant alarm, not least because Apis mellifera, the European honeybee, is thought to be responsible for pollination of 71 of the 100 crop species which provide 90% of the world’s food supply. Here we investigate the response to colony collapse disorder of a committed group of beekeepers who live in southern England, UK. These beekeepers are inspired by the writings of Rudolf Steiner and the principles of biodynamic agriculture, and they care deeply about bees. Drawing on Judith Butler’s work on vulnerability as a shared condition of living, we examine the philosophies and practices of alternative apiculture along two axes: the gifts of honey and poison; longing, connection and bee-worship. The first emphasizes how poison and honey draw bee and beekeeper together in uneven gift relations; the second axis emphasizes how beekeepers make their bodies and their selves vulnerable to bees. We show how these beekeepers want us to do more than reshape bees’ vulnerability to colony collapse disorder; they want to recognize, and reconstitute, their own vulnerability to the bee. The lessons to be drawn are less about solving bee decline and more about how becoming less uncomfortable with vulnerability and seeking to put ourselves at risk to others becomes an ethical practice. The example of these alternative beekeepers suggests that we might learn to accept more generously the risks of cohabiting with awkward nonhumans, so as to loosen the hegemonic grip of a self-certain subject that is disrupted by an outsider.

  10. Sequence-based analysis of the Vitis vinifera L. cv Cabernet Sauvignon grape must mycobiome in three South African vineyards employing distinct agronomic systems

    Directory of Open Access Journals (Sweden)

    MATHABATHA EVODIA SETATI

    2015-11-01

    Full Text Available Recent microbiomic research of agricultural habitats has highlighted tremendous microbial biodiversity associated with such ecosystems. Data generated in vineyards have furthermore highlighted significant regional differences in vineyard biodiversity, hinting at the possibility that such differences might be responsible for regional differences in wine style and character, a hypothesis referred to as microbial terroir. The current study further contributes to this body of work by comparing the mycobiome associated with South African (SA Cabernet Sauvignon grapes in three neighboring vineyards that employ different agronomic approaches, and comparing the outcome with similar data sets from Californian vineyards. The aim of this study was to fully characterize the mycobiomes associated with the grapes from these vineyards. The data revealed approximately 10 times more fungal diversity than what is typically retrieved from culture-based studies. The Biodynamic vineyard was found to harbor a more diverse fungal community (H = 2.6 than the conventional (H = 2.1 and integrated (H = 1.8 vineyards. The data show that ascomycota are the most abundant phylum in the three vineyards, with Aureobasidium pullulans and its close relative Kabatiella microsticta being the most dominant fungi. This is the first report to reveal a high incidence of K. microsticta in the grape/wine ecosystem. Different common wine yeast species, such as Metschnikowia pulcherrima and Starmerella bacillaris dominated the mycobiome in the three vineyards. The data show that the filamentous fungi are the most abundant community in grape must although they are not regarded as relevant during wine fermentation. Comparison of metagenomic datasets from the three SA vineyards and previously published data from Californian vineyards revealed only 25% of the fungi in the SA dataset was also present in the Californian dataset, with greater variation evident amongst ubiquitous epiphytic fungi.

  11. Lawrence Berkeley Laboratory Institutional Plan FY 1987-1992

    Energy Technology Data Exchange (ETDEWEB)

    Various

    1986-12-01

    The Lawrence Berkeley Laboratory, operated by the University of California for the Department of Energy, provides national scientific leadership and supports technological innovation through its mission to: (1) Perform leading multidisciplinary research in general sciences and energy sciences; (2) Develop and operate unique national experimental facilities for use by qualified investigators; (3) Educate and train future generations of scientists and engineers; and (4) Foster productive relationships between LBL research programs and industry. The following areas of research excellence implement this mission and provide current focus for achieving DOE goals. GENERAL SCIENCES--(1) Accelerator and Fusion Research--accelerator design and operation, advanced accelerator technology development, accelerator and ion source research for heavy-ion fusion and magnetic fusion, and x-ray optics; (2) Nuclear Science--relativistic heavy-ion physics, medium- and low-energy nuclear physics, nuclear theory, nuclear astrophysics, nuclear chemistry, transuranium elements studies, nuclear data evaluation, and detector development; (3) Physics--experimental and theoretical particle physics, detector development, astrophysics, and applied mathematics. ENERGY SCIENCES--(1) Applied Science--building energy efficiency, solar for building systems, fossil energy conversion, energy storage, and atmospheric effects of combustion; (2) Biology and Medicine--molecular and cellular biology, diagnostic imaging, radiation biophysics, therapy and radiosurgery, mutagenesis and carcinogenesis, lipoproteins, cardiovascular disease, and hemopoiesis research; (3) Center for Advanced Materials--catalysts, electronic materials, ceramic and metal interfaces, polymer research, instrumentation, and metallic alloys; (4) Chemical Biodynamics--molecular biology of nucleic acids and proteins, genetics of photosynthesis, and photochemistry; (5) Earth Sciences--continental lithosphere properties, structures and

  12. Large uncertainty in soil carbon modelling related to carbon input calculation method

    Science.gov (United States)

    Keel, Sonja G.; Leifeld, Jens; Taghizadeh-Toosi, Arezoo; Oleson, Jørgen E.

    2016-04-01

    A model-based inventory for carbon (C) sinks and sources in agricultural soils is being established for Switzerland. As part of this project, five frequently used allometric equations that estimate soil C inputs based on measured yields are compared. To evaluate the different methods, we calculate soil C inputs for a long-term field trial in Switzerland. This DOK experiment (bio-Dynamic, bio-Organic, and conventional (German: Konventionell)) compares five different management systems, that are applied to identical crop rotations. Average calculated soil C inputs vary largely between allometric equations and range from 1.6 t C ha-1 yr-1 to 2.6 t C ha-1 yr-1. Among the most important crops in Switzerland, the uncertainty is largest for barley (difference between highest and lowest estimate: 3.0 t C ha-1 yr-1). For the unfertilized control treatment, the estimated soil C inputs vary less between allometric equations than for the treatment that received mineral fertilizer and farmyard manure. Most likely, this is due to the higher yields in the latter treatment, i.e. the difference between methods might be amplified because yields differ more. To evaluate the influence of these allometric equations on soil C dynamics we simulate the DOK trial for the years 1977-2004 using the model C-TOOL (Taghizadeh-Toosi et al. 2014) and the five different soil C input calculation methods. Across all treatments, C-TOOL simulates a decrease in soil C in line with the experimental data. This decline, however, varies between allometric equations (-2.4 t C ha-1 to -6.3 t C ha-1 for the years 1977-2004) and has the same order of magnitude as the difference between treatments. In summary, the method to estimate soil C inputs is identified as a significant source of uncertainty in soil C modelling. Choosing an appropriate allometric equation to derive the input data is thus a critical step when setting up a model-based national soil C inventory. References Taghizadeh-Toosi A et al. (2014) C

  13. Distribution of β-carotene-encapsulated polysorbate 80-coated poly(D, L-lactide-co-glycolide nanoparticles in rodent tissues following intravenous administration

    Directory of Open Access Journals (Sweden)

    Miyazawa T

    2015-11-01

    Full Text Available Taiki Miyazawa,1,2 Kiyotaka Nakagawa,1,2 Takahiro Harigae,2 Ryo Onuma,2 Fumiko Kimura,2 Tomoyuki Fujii,3 Teruo Miyazawa4,5 1Vascular Biology Laboratory, Jean Mayer USDA (United States Department of Agriculture-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 2Food and Biodynamic Chemistry Laboratory, 3Terahertz Optical & Food Engineering Laboratory, Graduate School of Agricultural Science, 4Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe, 5Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan Purpose: Biodegradable nanoparticles (NPs composed of poly(D, L-lactide-co-glycolide (PLGA have attracted considerable attention as delivery systems of drugs and antioxidative compounds, such as β-carotene (BC. Intravenous (IV administration of BC-containing PLGA-NPs (BC-PLGA-NPs coated with polysorbate 80 (PS80 has been shown to effectively deliver BC to the brain. However, the whole-body distribution profile of BC is still not clear. Therefore, we investigated the accumulation of BC in various organs, including the brain, following IV administration of PS80-coated BC-PLGA-NPs in rats.Methods: PS80-coated and uncoated BC-PLGA-NPs were prepared by solvent evaporation, and administered intravenously to Sprague Dawley rats at a BC dose of 8.5 mg/rat. Accumulation of BC in various organs (brain, heart, liver, lungs, and spleen and blood plasma was evaluated by high performance liquid chromatography with ultraviolet (UV detection, 1 hour after administration.Results: We prepared PS80-coated BC-PLGA-NPs with an entrapment efficiency of 14%, a particle size of 260 nm, and a zeta potential of -26 mV. Coating with PS80 was found to result in significant accumulation of BC in the lungs, rather than in the brain and other tissues. Further, plasma levels of BC in the PS80-coated BC-PLGA-NP group were much lower than those of the uncoated

  14. Self-Organized Biological Dynamics and Nonlinear Control

    Science.gov (United States)

    Walleczek, Jan

    2006-04-01

    The frontiers and challenges of biodynamics research Jan Walleczek; Part I. Nonlinear Dynamics in Biology and Response to Stimuli: 1. External signals and internal oscillation dynamics - principal aspects and response of stimulated rhythmic processes Friedemann Kaiser; 2. Nonlinear dynamics in biochemical and biophysical systems: from enzyme kinetics to epilepsy Raima Larter, Robert Worth and Brent Speelman; 3. Fractal mechanisms in neural control: human heartbeat and gait dynamics in health and disease Chung-Kang Peng, Jeffrey M. Hausdorff and Ary L. Goldberger; 4. Self-organising dynamics in human coordination and perception Mingzhou Ding, Yanqing Chen, J. A. Scott Kelso and Betty Tuller; 5. Signal processing in biochemical reaction networks Adam P. Arkin; Part II. Nonlinear Sensitivity of Biological Systems to Electromagnetic Stimuli: 6. Electrical signal detection and noise in systems with long-range coherence Paul C. Gailey; 7. Oscillatory signals in migrating neutrophils: effects of time-varying chemical and electrical fields Howard R. Petty; 8. Enzyme kinetics and nonlinear biochemical amplification in response to static and oscillating magnetic fields Jan Walleczek and Clemens F. Eichwald; 9. Magnetic field sensitivity in the hippocampus Stefan Engström, Suzanne Bawin and W. Ross Adey; Part III. Stochastic Noise-Induced Dynamics and Transport in Biological Systems: 10. Stochastic resonance: looking forward Frank Moss; 11. Stochastic resonance and small-amplitude signal transduction in voltage-gated ion channels Sergey M. Bezrukov and Igor Vodyanoy; 12. Ratchets, rectifiers and demons: the constructive role of noise in free energy and signal transduction R. Dean Astumian; 13. Cellular transduction of periodic and stochastic energy signals by electroconformational coupling Tian Y. Tsong; Part IV. Nonlinear Control of Biological and Other Excitable Systems: 14. Controlling chaos in dynamical systems Kenneth Showalter; 15. Electromagnetic fields and biological

  15. Three-dimensional modeling of supine human and transport system under whole-body vibration.

    Science.gov (United States)

    Wang, Yang; Rahmatalla, Salam

    2013-06-01

    The development of predictive computer human models in whole-body vibration has shown some success in predicting simple types of motion, mostly for seated positions and in the uniaxial vertical direction. The literature revealed only a handful of papers that tackled supine human modeling in response to vertical vibration. The objective of this work is to develop a predictive, multibody, three-dimensional human model to simulate the supine human and underlying transport system in response to multidirectional whole-body vibration. A three-dimensional dynamic model of a supine human and its underlying transport system is presented in this work to predict supine-human biodynamic response under three-dimensional input random whole-body vibration. The proposed supine-human model consists of three interconnected segments representing the head, torso-arms, and pelvis-legs. The segments are connected via rotational and translational joints that have spring-damper components simulating the three-dimensional muscles and tissuelike connecting elements in the three x, y, and z directions. Two types of transport systems are considered in this work, a rigid support and a long spinal board attached to a standard military litter. The contact surfaces between the supine human and the underlying transport system are modeled using spring-damper components. Eight healthy supine human subjects were tested under combined-axis vibration files with a magnitude of 0.5 m/s2 (rms) and a frequency content of 0.5-16 Hz. The data from seven subjects were used in parameter identification for the dynamic model using optimization schemes in the frequency domain that minimize the differences between the magnitude and phase of the predicted and experimental transmissibility. The predicted accelerations in the time and frequency domains were comparable to those gathered from experiments under different anthropometric, input vibration, and transport conditions under investigation. Based on the

  16. Body composition as a frailty marker for the elderly community

    Directory of Open Access Journals (Sweden)

    Falsarella GR

    2015-10-01

    Full Text Available Gláucia Regina Falsarella,1 Lívia Pimenta Renó Gasparotto,1 Caroline Coutinho Barcelos,2 Ibsen Bellini Coimbra,1,2 Maria Clara Moretto,1 Mauro Alexandre Pascoa,3 Talita C B Rezende Ferreira,1 Arlete Maria Valente Coimbra1,41Gerontology Program, Faculty of Medical Sciences, 2Department of Medical Clinics, Faculty of Medical Sciences, 3Department Biodynamics of Movement, Faculty of Physical Education, 4Family Health Program, Gerontology Program, Faculty of Medical Sciences, State University of Campinas (Unicamp, Campinas, São Paulo, BrazilBackground: Body composition (BC in the elderly has been associated with diseases and mortality; however, there is a shortage of data on frailty in the elderly.Objective: To investigate the association between BC and frailty, and identify BC profiles in nonfrail, prefrail, and frail elderly people.Methods: A cross-sectional study comprising 235 elderly (142 females and 93 males aged ≥65 years, from the city of Amparo, State of São Paulo, Brazil, was undertaken. Sociodemographic and cognitive features, comorbidities, medication, frailty, body mass index (BMI, muscle mass, fat mass, bone mass, and fat percent (% data were evaluated. Aiming to examine the relationship between BC and frailty, the Mann–Whitney and Kruskal–Wallis nonparametric tests were applied. The statistical significance level was P<0.05.Results: The nonfrail elderly showed greater muscle mass and greater bone mass compared with the prefrail and frail ones. The frail elderly had greater fat % than the nonfrail elderly. There was a positive association between grip strength and muscle mass with bone mass (P<0.001, and a negative association between grip strength and fat % (P<0.001. Gait speed was positively associated with fat mass (P=0.038 and fat % (P=0.002. The physical activity level was negatively associated with fat % (P=0.022. The weight loss criterion was positively related to muscle mass (P<0.001, bone mass (P=0.009, fat mass

  17. Metabolic fate of poly-(lactic-co-glycolic acid-based curcumin nanoparticles following oral administration

    Directory of Open Access Journals (Sweden)

    Harigae T

    2016-06-01

    Full Text Available Takahiro Harigae,1 Kiyotaka Nakagawa,1 Taiki Miyazawa,2 Nao Inoue,3 Fumiko Kimura,1 Ikuo Ikeda,3 Teruo Miyazawa4,5 1Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan; 2Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 3Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, 4Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center, 5Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan Purpose: Curcumin (CUR, the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. Poly-(lactic-co-glycolic acid-based CUR nanoparticles (CUR-NP have recently been suggested to improve CUR bioavailability, but this has not been fully verified. Specifically, no data are available about curcumin glucuronide (CURG, the major metabolite of CUR found in the plasma following oral administration of CUR-NP. Herein, we investigated the absorption and metabolism of CUR-NP and evaluated whether CUR-NP improves CUR bioavailability.Methods: Following oral administration of CUR-NP in rats, we analyzed the plasma and organ distribution of CUR and its metabolites using high-performance liquid chromatography-tandem mass spectrometry. To elucidate the mechanism of increased intestinal absorption of CUR-NP, we prepared mixed micelles comprised of phosphatidylcholine and bile salts and examined the micellar solubility of CUR-NP. Additionally, we investigated the cellular incorporation of the resultant micelles into differentiated Caco-2 human intestinal cells.Results: Following in vivo administration of CUR-NP, CUR was effectively absorbed and present mainly as CURG in the plasma which contained significant amounts of the metabolite compared with

  18. Effects of +G_z exposure on gallbladder emptying function,cholecystokinin,and somatostatin in rabbits with high cholesterol diets

    Directory of Open Access Journals (Sweden)

    Guo-feng XIAO

    2011-12-01

    Full Text Available Objective The present study explores the effects of +Gz exposure on the gallbladder emptying function,cholecystokinin(CCK,and somatostatin(SS in rabbits with high cholesterol diets and investigates its mechanism in the occurrence of cholecystolithiasis.Methods Twenty-four male New Zealand rabbits were randomly divided into the high cholesterol diet(control group,n=8 and high cholesterol diet plus +Gz exposure groups.The latter was divided into the four-and six-week +Gz exposure groups(n=8 based on the exposure time.Radioimmunoassay was used to determine the CCK and SS contents of the gallbladder at the end of the experiment in the fourth and sixth weeks and to calculate the gallbladder volume and maximum emptying ratio.A microcomputer biodynamic pressure monitor was used to record the hydrostatic pressure in the gallbladder to measure its capacity.Moreover,the bile properties and formation of concretion were observed with the naked eye,and polarized light microscopy was used to observe cholesterin crystallization on the gallbladder wall.Results The gallbladder capacity increased upon +Gz exposure for four and six weeks,indicating that the maximum emptying ratio(E% decreased,the empty and residual volumes improved,and the pressure increased(P < 0.05.After +Gz exposure for four and six weeks,the CCK contents in the experimental groups were evidently lower than that in the control group and gradually decreased(P < 0.05 as the +Gz exposure time increased.On the other hand,after +Gz exposure for four and six weeks,the SS contents in the experimental groups were higher than that in the control group and gradually improved(P < 0.05 as the +Gz exposure time increased.After +Gz exposure for four and six weeks,bile was turbid and sticky with cholesterol crystals and without visible concretion.Conclusions Therefore,+Gz exposure may cause abnormal gallbladder emptying functions,decrease CCK content,increase SS content,and thus cause bile stasis

  19. DayCent modelling of Swiss cropping systems

    Science.gov (United States)

    Necpalova, Magdalena; Lee, Juhwan; Büchi, Lucie; Mäder, Paul; Mayer, Jochen; Charles, Raphael; van der Heijden, Marcel; Six, Johan

    2016-04-01

    There is a growing need to identify and evaluate sustainable greenhouse gas (GHG) mitigation options, their bio-economic feasibility in the agricultural sector, and support implementation of agricultural GHG mitigation activities that are an integral part of climate change strategies. In recent years, several ecosystem biogeochemical process-based models and comprehensive decision making tools integrated with these models have been developed. The DayCent model simulates all major ecosystem processes that affect soil C and N dynamics, including plant production, water flow, heat transport, SOC decomposition, N mineralization and immobilization, nitrification, denitrification, and methane oxidation. However, if the model is to be reliably used for identification of GHG mitigation options and climate change strategies across the EU agricultural regions, it requires site- and region-specific calibration and evaluation. Here, we calibrated and validated the model to Swiss climate and soil conditions and management options using available long-term experimental data. Data on crop productivity, soil organic carbon and N2O emissions were derived from four field sites located in Thervil (1977-2013), Frick (2003-2013), Changins (1971-2013), and Reckenholz (2009-2013) that have evaluated the effects of agricultural input systems (specifically, organic, biodynamic, and conventional with and without manure additions) and soil management options (various tillage practices and cover cropping). The preliminary results show that the DayCent model was able to reproduce 76% of variability in the crop productivity (n = 1 316) and 75% variability in measured soil organic carbon (n = 402) across all long-term trials. Model calibration was evaluated against independent proportions of the data. The uncertainty in model predictions induced by model structure and uncertainty in the measured data still needs to be further evaluated using the Monte Carlo approach. The calibrated model will be

  20. The experiment in rat model with alendronate inhibiting abnormal alve olar bone resorption%Alendronate阻止牙槽骨骨吸收的实验研究

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 杨宗萍; 于世凤

    2001-01-01

    Objective.Osteoporosis and periodontal disease animal models were used to evaluate the anti-resorption effect of alendr onate on bone.Methods.To establish osteoporosis and alveo lar bone resorption animal models.The experimental groups (ovariectomized dental ligature group and simple dental ligature group) were given alendronate in 0. 5mg/kg BW by subcutaneous injection after six weeks of ovariectomy and dental ligature,three times a week for 6 weeks.All the animals were sacrifised 12 weeks after the operation.The blood samples were collected for determination of bioch emical indexes.The left femora and jaw bone were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics.Results.As compared with the control groups (without alendronate),the values of experimental groups (with alendronate ) were all significantly improved on bone density and bone anti-curve power.The alkaline phosphatase,calcium in serum of ovariectomy groups (without alendronate ) were obviously increased.In the alendronate group,however,these indexes werec lose to normal levels.In histomorphometry,there were little inflammation in gingiva and less level alveolar bone resorption in the experimental groups;but there was obvious gingivitis and level alveolar bone resorption in the control groups .Conclusion.Alendronate can effectively treat osteoporosis,increase bone volume and prevent bone lose in ovariectomized female rats and inhibit pathological alveolar bone resorption.%目的 评价双膦酸盐Alendronate抑制牙槽骨骨吸收的作用。方法 建立骨质疏松及牙槽骨吸收动物模型,建模术后六周,给实验组皮下注射Alendronate每周3次,共6周;用血生化指标骨生物力学、骨密度测量、组织形态学等方法进行药效评价。结果 股骨骨密度对照 组与用药组相比明显降低(P<0.01);血清碱性磷酸酶对照组与用药组相比明显升

  1. Soil properties and not inputs control carbon : nitrogen : phosphorus ratios in cropped soils in the long term

    Science.gov (United States)

    Frossard, Emmanuel; Buchmann, Nina; Bünemann, Else K.; Kiba, Delwende I.; Lompo, François; Oberson, Astrid; Tamburini, Federica; Traoré, Ouakoltio Y. A.

    2016-02-01

    Stoichiometric approaches have been applied to understand the relationship between soil organic matter dynamics and biological nutrient transformations. However, very few studies have explicitly considered the effects of agricultural management practices on the soil C : N : P ratio. The aim of this study was to assess how different input types and rates would affect the C : N : P molar ratios of bulk soil, organic matter and microbial biomass in cropped soils in the long term. Thus, we analysed the C, N, and P inputs and budgets as well as soil properties in three long-term experiments established on different soil types: the Saria soil fertility trial (Burkina Faso), the Wagga Wagga rotation/stubble management/soil preparation trial (Australia), and the DOK (bio-Dynamic, bio-Organic, and "Konventionell") cropping system trial (Switzerland). In each of these trials, there was a large range of C, N, and P inputs which had a strong impact on element concentrations in soils. However, although C : N : P ratios of the inputs were highly variable, they had only weak effects on soil C : N : P ratios. At Saria, a positive correlation was found between the N : P ratio of inputs and microbial biomass, while no relation was observed between the nutrient ratios of inputs and soil organic matter. At Wagga Wagga, the C : P ratio of inputs was significantly correlated to total soil C : P, N : P, and C : N ratios, but had no impact on the elemental composition of microbial biomass. In the DOK trial, a positive correlation was found between the C budget and the C to organic P ratio in soils, while the nutrient ratios of inputs were not related to those in the microbial biomass. We argue that these responses are due to differences in soil properties among sites. At Saria, the soil is dominated by quartz and some kaolinite, has a coarse texture, a fragile structure, and a low nutrient content. Thus, microorganisms feed on inputs (plant residues, manure). In contrast, the soil at

  2. Pathways of trace metal uptake in the lugworm Arenicola marina

    Energy Technology Data Exchange (ETDEWEB)

    Casado-Martinez, M.C. [Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom)], E-mail: c.casado-martinez@nhm.ac.uk; Smith, B.D. [Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Valls, T.A. del [Unesco UNITWIN Wicop Chair, Department of Physical-Chemistry, University of Cadiz, Poligono Industrial Rio San Pedro s/n, C.P. 11510 Puerto Real, Cadiz (Spain); Rainbow, P.S. [Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom)

    2009-04-02

    fast-exchanging compartment after the water-only exposure (0.025 {+-} 0.012 and 0.020 {+-} 0.004 d{sup -1} for the Northumberland and Thames populations, respectively). A biodynamic model was used to estimate the relative importance of the dissolved phase versus ingested sediment as source of metal for the worms, showing that more than 90% of the Zn and Cd and more than 70% of Ag in lugworms is accumulated from sediment ingestion at realistic environmental concentrations. The model also shows that metal accumulation is highly dependent on the ingestion rate and assimilation efficiency.

  3. Estimativa da gordura corporal através de equipamentos de bioimpedância, dobras cutâneas e pesagem hidrostática Comparison of body fat estimation by bioelectric impedance, skinfold thickness, and underwater weighing

    Directory of Open Access Journals (Sweden)

    Maurício Nunes Rodrigues

    2001-08-01

    Full Text Available A estimativa do percentual de gordura (%G pela bioimpedância (BIA tem como vantagem a simplicidade da medida. Contudo, a confiabilidade da BIA tem sofrido críticas. O objetivo deste estudo foi comparar a estimativa do %G através das técnicas de bioimpedância (RJL-101; Byodinamics A-310, Maltron BF-900 e BF-906, de dobras cutâneas (DC e da pesagem hidrostática (PH. Observaram-se 25 indivíduos, homogeneizados segundo raça (branca, gênero (masculino e idade (18 a 36 anos. Para a medida de BIA foi utilizada a padronização proposta por Lukaski et al. (1985, 1986. Para as DC foram utilizadas as equações de å 3 DC e å 7 DC (Jackson, Pollock, 1978. Os valores de %G e de volume residual para PH foram preditos, respectivamente, pelas equações de Siri (1961 e Goldman e Becklake (1959. A análise estatística compreendeu: a comparação entre os métodos através da ANOVA com medidas repetidas seguida de testes post-hoc de Tukey; b correlação de Pearson (r; e c cálculo do erro padrão de estimativa (SEE das técnicas em relação à PH. Os resultados indicaram que: a as medidas de BIA não diferiram significativamente, entre si, para o %G estimado; b As medidas dos aparelhos A-310 e BF-906 não coincidiram com a PH (p The main advantage of the bioelectric impedance method (BIA in the determination of body fat (%BF is the simplicity of the procedure. However, its accuracy and reliability have been criticized. The purpose of this study was to compare the %BF obtained by BIA (RJL-101; Biodynamics A-310, Maltron BF-900 e BF-906, by skinfold thickness (ST, and by underwater weighing (UW. Twenty-five subjects, divided in homogenous groups according to age (18 to 36 years, sex (men, and race (white participated in the study. BIA measures were taken using the Lukaski et al. standardization (1985,1986. ST was taken by using the equation of 3 and 7 skinfolds (Jackson, Pollock, 1978. The values of %BF and residual volume for the UW were estimated

  4. Estimativa da massa muscular esquelética em mulheres idosas: validade da impedância bioelétrica Validity of bioelectrical impedance analysis for the estimation of skeletal muscle mass in elderly women

    Directory of Open Access Journals (Sweden)

    Cassiano Ricardo Rech

    2010-04-01

    Full Text Available O presente estudo tem como objetivos: a verificar a concordância entre os métodos da impedância bioelétrica (BIA e da absortometria radiológica de dupla energia (DXA para a estimativa da massa muscular esquelética (MME; e b analisar o poder preditivo de variáveis antropométricas e da BIA para a predição da MME em idosas. Foram avaliadas 120 mulheres (60 a 81 anos, residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa corporal e estatura; a resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310, e pela DXA de corpo inteiro (Lunar Prodigy DF + 14319 Radiation e software 7.52.002 DPX-L. A diferença entre os métodos foi verificada pelo teste t pareado, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão linear múltipla, adotando nível de significância de p 0,01. Observou-se que a BIA subestimou em média 0,8kg (IC95%: -3,7; 2,0kg a MME, quando comparada com a DXA. Foi observada alta correlação entre os métodos (r² = 0,75; p The objectives of the present study were: a to determine the agreement between bioelectrical impedance analysis (BIA and dual-energy X-ray absorptiometry (DXA for the estimation of skeletal muscle mass (SMM, and b to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in elderly women. A total of 120 women (60 to 81 years, living in the southern region of Brazil, were studied. Anthropometric variables (body weight and height were measured. Resistance and hydration of fat-free tissues were measured by tetrapolar BIA (Biodynamics, BF-310 and by whole-body DXA (Lunar Prodigy DF + 14319 Radiation and DPX-L software, version 7.52.002. Differences between methods were determined using the paired t-test, analysis of residuals and correlation coefficient. The predictive value of the

  5. Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs.

    Science.gov (United States)

    Kumar, Rajnish; Nordberg, Agneta; Darreh-Shori, Taher

    2016-01-01

    -β interacts readily in an apolipoprotein-facilitated manner with butyrylcholinesterase, forming highly stable and soluble complexes, BAβACs, which can be separated in their native states by sucrose density gradient technique. Enzymological analyses further evinced that amyloid-β concentration dependently increased the acetylcholine-hydrolyzing capacity of cholinesterases. In silico biomolecular analysis further deciphered the allosteric amino acid fingerprint of the amyloid-β-cholinesterase molecular interaction in formation of BAβACs. In the case of butyrylcholinesterase, the results indicated that amyloid-β interacts with a putative activation site at the mouth of its catalytic tunnel, most likely leading to increased acetylcholine influx into the catalytic site, and thereby increasing the intrinsic catalytic rate of butyrylcholinesterase. In conclusion, at least one of the native physiological functions of amyloid-β is allosteric modulation of the intrinsic catalytic efficiency of cholinesterases, and thereby regulation of synaptic and extrasynaptic cholinergic signalling. High apolipoprotein-E may pathologically alter the biodynamics of this amyloid-β function.

  6. [The Omega "Omega" pulley plasty: a new technique for the surgical management of the De Quervain's disease].

    Science.gov (United States)

    Bakhach, J; Sentucq-Rigal, J; Mouton, P; Boileau, R; Panconi, B; Guimberteau, J-C

    2006-02-01

    the pulley and to reconstruct it suturing the different flaps. It can generate adherences between the extensor tendons, the overlying skin and the collateral branches of the radial nerve. The authors present a new and original plasty procedure of the first extensor compartment pulley, the "Omega" Omega plasty. It consists to liberate the anterior attachment of the pulley over the anterior lip of the styloïd process respecting its continuity with the periosteum flap. This conservative procedure is very interesting; it permits enough expansion of the tunnel volume decompressing the extensor tendons as a treatment of the De Quervain disease and respecting the anatomy and the continuity of the osteo-fibrous tunnel. This technique is simple, reliable and respects the first ray extensor tendons gliding physiology and biodynamic. In spite of our short clinical experience with only ten cases, all the patients retrieve a normal function of the thumb with complete disappearance of the first ray tenderness and pain without any complications. These preliminary results are encouraging and push us to consider the "Omega" plasty as a first choice for the surgical treatment of the De Quervain tenosynovitis.

  7. Biological degradation of chernozems under irrigation

    Directory of Open Access Journals (Sweden)

    Oksana Naydyonova

    2014-12-01

    reduction the number of microorganisms and the diversity of fungi species, repression of cellulose destroying capacity, decrease invertase activity and the rate of humification, intensifying mineralization processes and soil toxicity increasing. Long-term irrigation of ordinary chernozem (Kharkiv Region with fresh water in moderate regime under 7-field crop rotation including alfalfa caused no disturbances of microbial cenosis. In this case parameters of biological indices did not deviate from the level of its non-irrigated analogue. Irrigation with saline water causes more profound negative changes of microbial cenosis of chernozem, which not always can be corrected using agroameliorative techniques. Intensive irrigation with saline water with total mineralization from 1.2 to 2.2 g/l of ordinary chernozem (Odesa Region for 13 years has led to a significant degradation changes in the structure and functioning of its microbial cenosis, its radical alteration such as oppression of microflora, decrease in the number of its main groups by 30 – 40 %, intensification of its mineralization function. Application of agroameliorative techniques (such as annually use of phosphogypsum 3 t/ha or /and complex measures (phosphogypsum 3 t/ha annually + N150P90K60 + manure 18 t/ha of crop rotation enable to regulate of soil biodynamic processes and partially or completely eliminate the phenomena of biological degradation. It was stated that after the cessation of irrigation the degradation changes of ordinary chernozem’s biological properties caused by irrigation with saline water were gradually restored.

  8. 阿仑膦酸钠防治牙槽骨吸收的实验研究%The treatment of osteoporosis and bone resorption of alveoli with alendronate in rat model

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 杨宗萍; 于世凤

    2001-01-01

    目的用骨质疏松及牙槽骨吸收动物模型评价阿仑膦酸盐对骨吸收的防治作用。方法建立骨质疏松及牙槽骨吸收的动物模型,建模手术次日,给实验组皮下注射阿仑膦酸钠液,每周3次,共6周。用血生化指标、骨生物力学、骨密度测量及组织形态学方法进行药效评价。结果股骨密度:对照组(0.123 g/cm2)与实验组(0.151 g/cm2)相比明显降低(P<0.01);血清碱性磷酸酶:对照组(259.63 U/L)与实验组(151.13 U/L)相比明显升高(P<0.01);骨生物力学各项指标,实验组与对照组也有明显差异。组织形态学:实验组牙龈轻度炎症,牙槽嵴顶未见明显吸收;对照组牙龈乳突炎症明显,上皮钉突增生,炎细胞浸润,牙槽嵴顶明显吸收。结论阿仑膦酸钠能减少骨质丢失从而可以防止骨质疏松及病理性牙槽骨骨吸收。%Objective To evaluate the anti-osteoporosis effect of alendronate on bone in rat model. Methods The osteoporosis and alveolar bone resorption animal model were established in rats. The experimental groups were given alendronate in 5 mg/kg BW by subcutaneous injection after first day of ovariectomy and dental ligature, three times a week for 6 weeks. All the animals were sacrifised 12 weeks after the operation. The blood samples were collected for determination of biochemical indices. The left femora and jaw bones were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics. Results As compared with the control groups(without alendronate), the values of experimental groups (with alendronate) were all significantly improved on bone density, bone anti-flexure ability and body weight. The alkaline phosphatase, calcium in serum of ovariectomy groups(without alendronate) were obviously increased. In the experimental group, however, these indices were close to normal levels. In

  9. Ocular higher-order aberrations features analysis after corneal refractive surgery

    Institute of Scientific and Technical Information of China (English)

    WANG Yan; ZHAO Kan-xing; HE Ji-chang; JIN Ying; ZUO Tong

    2007-01-01

    -3 in LASIK was higher and C5+1 and C5+3 were lower than those in the PRK group. C40 (spherical aberration) values were similar between PRK and LASIK, however, C3-1 and C31 (coma) in LASIK were higher than those in PRK, but these differences are of no statistical significance.Conclusions PRK and LASIK may increase ocular higher-order aberrations, but they both have their own features.The difference between the two types of surgery may be correlated with the change of the corneal shape, the conversion of biodynamics, the healing of the corneal cut, and re-structured corneal epithelium and/or the stroma.

  10. Selenium in ecosystems within the mountaintop coal mining and valley-fill region of southern West Virginia-assessment and ecosystem-scale modeling

    Science.gov (United States)

    Presser, Theresa S.

    2013-01-01

    different regulatory pathways and guidelines. The range of model outcomes accounts for critical sources of variability and establishes whether site and food-web characterization were adequate to represent the dynamics of the system with certainty. This is especially true in terms of particulate-material phases at the base of the food web and utilization of Kd in different hydrologic settings. For streams, a range of field-derived Kdds were applied to food-web exposure scenarios within a framework of locational and hydrologic variables (area of stream basin; stream gradient and discharge) that may affect the magnitude of Kd. Overlaying even a coarse temporal scale that acknowledges variability in stream dissolved Se and Se speciation, such as through seasonal derivation of Kd, can substantially narrow model uncertainty. Modeling that constrains the place and time of greatest ecosystem Se sensitivity within a specified food web gives insight into Se risk and identifies controlling management alternatives within a watershed or stream basin. If there is a range of hydrologic settings, specificity is needed to establish a hierarchy of in-stream and off-stream habitats for a watershed approach that takes into account Se-enriched water moving through different Kd and food web environments. If there is a range of predator vulnerabilities (measured as a combination of food-web Se biodynamics and response in Se toxicity tests) within the site-specific community of fish species to be protected, then choice of fish species is critical to protection because it determines the food web and, hence, the magnitude of biotransfer through which Se is modeled. Whether creek chub is representative of the vulnerability to Se of all fish species encountered within the study-site ecosystems will require additional species-specific data and analysis. A range of site-specific scenarios illustrated here set model outcomes, but the final quantitative evaluation of alternatives and their implications

  11. 大鼠颈椎间盘退行性变后软骨细胞凋亡及形态学改变%Chondrocyte apoptosis and morphological changes of degenerated cervical intervertebral disc in rats

    Institute of Scientific and Technical Information of China (English)

    王拥军; 施杞; 李家顺; 贾连顺; 周重建; 刘梅; 周泉

    2004-01-01

    背景:椎间盘软骨终板是椎间盘营养渗透的主要途径,又是维持脊柱生物力学的重要结构之一.对其重要性的认识及相关研究日益深入,但对椎间盘退行性变的确切原因仍不清楚.目的:动态观察大鼠颈部动静力失去平衡后颈椎间盘软骨细胞凋亡的形态学改变以及凋亡率.设计:采用完全随机对照设计.地点和对象:实验在上海中医药大学脊柱病研究所完成,对象为8月龄清洁级SD大鼠60只,雌雄各30只.干预:将雌雄大鼠分别按随机数字表法分为3,5,7月对照组与模型组,每组10只,雌雄各5只.取大鼠颈背部正中纵向切口,切开皮肤后,充分游离各层肌肉,横向切断深群颈夹肌和头、颈、寰最长肌,完全切除颈髂肋肌与头半棘肌,然后再依次切断C2~C7棘上和棘间韧带,建立的动静力失衡性颈椎间盘退行性变模型.主要观察指标:3,5,7月后椎间盘软骨细胞凋亡程度.结果:退行性变椎间盘内有典型凋亡的软骨细胞.与对照组比较,各个模型组软骨细胞凋亡指数明显升高(P<0.01);模型组间比较,TUNEL法5,7月软骨细胞凋亡指数分别为36.59±5.93和36 36±5.13较3月(27.73±4.12)明显升高(P<0.01),流式细胞仪PI法5,7月细胞凋亡指数分别为37.56±3.82和28.02±3.48较3月(21.45±2.23)明显升高(P<0.01).结论:退行性变椎间盘软骨终板内软骨细胞凋亡数目增多,这可能是椎间盘退行性变的重要机制之一.%BACKGROUND: The cartilage endplate of intervertebral disc, the main way of the nutrition pervasion in intervertebral disc, is also one of the important structures in maintaining the biodynamics of spine. Though its importance and related researches were recognized further, the actual reasons for degeneration of intervertebral disc still remains unclear.OBJECTIVE: To dynamically observe the morphological changes of the chondyrocyte apoptosis and the apoptotic rate of chondyrocytes in the degenerated

  12. 激光针刀联合微创介入治疗LDH的CT定量IPP图像变化比较%Comparison of CT Quantitative IPP Images in the Treatment of Laser Nee-dle Knife and Minimally Invasive Intervention for Lumbar Disc Herniation

    Institute of Scientific and Technical Information of China (English)

    汤勇; 陈雄; 徐应乐; 汤治中; 张晓明

    2016-01-01

    Objective To have the quantitative study on CT imaging changes in the treatment of la-ser needle knife and minimally invasive intervention for lumbar disc herniation( LDH)so as to evaluate the biodynamic impact of this therapy for degenerative LDH and explore its effect mechanism and open a new ap-proach to the treatment of this disease. Methods The enrolled 180 cases according to the inclusive criteria were randomized into a laser needle knife group,a minimally invasive intervention group and a combined therapy group,60 cases in each one. In the laser needle knife group,the laser needle knife therapy was used. In the minimally invasive intervention group,the minimally invasive intervention of plasma radiofrequency and collagenase chemonucleolysis( CCNL)were adopted. In the combined therapy group,the therapeutic methods in the previous two groups were used in combination. At the end of treatment,IPP image software was used to measure and compare CT image protrusion area,protrusion degree,gap distance and vertebral shifting degree of the intervertebral disc among the three groups. SPSS19. 0 was used for statistical analysis on all of the da-ta. Results After treatment,in comparison of CT quantitative image characteristic changes,the protrusion ar-ea and degree in the combined therapy group and minimally invasive intervention group were reduced appar-ently as compared with those before treatment,indicating the significant difference(P﹤0. 05). The changes were not obvious in the laser needle knife group. The lumbar vertebral shifting degree was reduced in the combined therapy group and minimally invasive intervention group,in which the reducing amplitude in the combined therapy group was much more apparent. The changes were not obvious in the laser needle knife group. The change in gap distance was not apparent in the three groups(P﹥0. 05). Conclusion The com-bined therapy of laser needle knife and minimally invasive intervention effectively shortens protrusion

  13. 股骨柄假体的二维生物力学评价与优化选择%Two-dimensional biomechanics evaluation and the optimal selection of a femoral stem prosthesis

    Institute of Scientific and Technical Information of China (English)

    陆晴友; 曲爱丽; 王芳; 吴岳嵩; 王成焘

    2008-01-01

    背景:人工髋关节置换术前选择假体时,不仅要考虑在几何学上达到与患者股骨髓腔的匹配,而且还要在生物力学性能上达到最优,这对提高全髋关节置换术后疗效,具有较现实的意义.目的:对4组与股骨匹配的股骨柄假体进行生物力学的评价,寻找与正常股骨力学分布最为接近的股骨柄假体.设计:对比观察.单位:同济大学附属东方医院骨科、解放军第二军医大学长海医院骨科、上海交通大学机械与动力工程学院.材料:实验于2004-12/2005-10 在上海交通大学机械与动力工程学院生命质量与机械工程实验室完成.选用无髋部疾患、股骨近端形态正常志愿者(男性,40岁,身高175 cm,体质量78 kg)的股骨拍摄标准正位X射线片,并以DICOM格式存入存贮器中.志愿者签署知情同意书,同时报医学伦理委员会审批.模板:Ⅰ号假体:Zimmer versys Fiber Metal Taper11#;Ⅱ号假体:Plus APL 2#;Ⅲ号假体:Welink Ribbed system cementless11#:Ⅳ号假体:Lima F2L 1#.方法:在Matlab中导入股骨近端X射线正位片及4组股骨-股骨柄假体模板的bmp格式的图像文件,分别提取股骨、带假体模板的股骨二维轮廓数据,利用ANSYS软件建立股骨、股骨-股骨柄几何模型及二维非线性有限元模型,负荷加载后对股骨近端的应力分布进行分析、比较.主要观察指标:股骨近端的应力分布.结果:Ⅰ,Ⅳ号假体对所研究的股骨而言其应力大小及分布与正常股骨相近,但两者相比Ⅰ号更为接近,应为最佳选择.结论:通过基于X射线片与模板的股骨柄假体二维生物力学的分析比较,可对股骨柄假体的生物力学性能作出评价,为假体的优化选择提供依据.%BACKGROUND:Prosthesis selection for total hip replacement is determined by geometrical matching with femoral medullary cavity of patients and the optimal biodynamics.It is of great significance for elevating outcomes of total hip