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Sample records for biochemical systems theory

  1. The application of information theory to biochemical signaling systems.

    Science.gov (United States)

    Rhee, Alex; Cheong, Raymond; Levchenko, Andre

    2012-08-01

    Cell signaling can be thought of fundamentally as an information transmission problem in which chemical messengers relay information about the external environment to the decision centers within a cell. Due to the biochemical nature of cellular signal transduction networks, molecular noise will inevitably limit the fidelity of any messages received and processed by a cell's signal transduction networks, leaving it with an imperfect impression of its environment. Fortunately, Shannon's information theory provides a mathematical framework independent of network complexity that can quantify the amount of information that can be transmitted despite biochemical noise. In particular, the channel capacity can be used to measure the maximum number of stimuli a cell can distinguish based upon the noisy responses of its signaling systems. Here, we provide a primer for quantitative biologists that covers fundamental concepts of information theory, highlights several key considerations when experimentally measuring channel capacity, and describes successful examples of the application of information theoretic analysis to biological signaling.

  2. Chemical reaction network approaches to Biochemical Systems Theory.

    Science.gov (United States)

    Arceo, Carlene Perpetua P; Jose, Editha C; Marin-Sanguino, Alberto; Mendoza, Eduardo R

    2015-11-01

    This paper provides a framework to represent a Biochemical Systems Theory (BST) model (in either GMA or S-system form) as a chemical reaction network with power law kinetics. Using this representation, some basic properties and the application of recent results of Chemical Reaction Network Theory regarding steady states of such systems are shown. In particular, Injectivity Theory, including network concordance [36] and the Jacobian Determinant Criterion [43], a "Lifting Theorem" for steady states [26] and the comprehensive results of Müller and Regensburger [31] on complex balanced equilibria are discussed. A partial extension of a recent Emulation Theorem of Cardelli for mass action systems [3] is derived for a subclass of power law kinetic systems. However, it is also shown that the GMA and S-system models of human purine metabolism [10] do not display the reactant-determined kinetics assumed by Müller and Regensburger and hence only a subset of BST models can be handled with their approach. Moreover, since the reaction networks underlying many BST models are not weakly reversible, results for non-complex balanced equilibria are also needed. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Subcellular metabolic organization in the context of dynamic energy budget and biochemical systems theories

    NARCIS (Netherlands)

    Vinga, S.; Neves, A.S.; Santos, H.; Brandt, B.W.; Kooijman, S.A.L.M.

    2010-01-01

    The dynamic modelling of metabolic networks aims to describe the temporal evolution of metabolite concentrations in cells. This area has attracted increasing attention in recent years owing to the availability of high-throughput data and the general development of systems biology as a promising

  4. Thermodynamic analysis of biochemical systems

    International Nuclear Information System (INIS)

    Yuan, Y.; Fan, L.T.; Shieh, J.H.

    1989-01-01

    Introduction of the concepts of the availability (or exergy), datum level materials, and the dead state has been regarded as some of the most significant recent developments in classical thermodynamics. Not only the available energy balance but also the material and energy balances of a biological system may be established in reference to the datum level materials in the dead state or environment. In this paper these concepts are illustrated with two examples of fermentation and are shown to be useful in identifying sources of thermodynamic inefficiency, thereby leading naturally to the rational definition of thermodynamic efficiency of a biochemical process

  5. Probabilistic sensitivity analysis of biochemical reaction systems.

    Science.gov (United States)

    Zhang, Hong-Xuan; Dempsey, William P; Goutsias, John

    2009-09-07

    Sensitivity analysis is an indispensable tool for studying the robustness and fragility properties of biochemical reaction systems as well as for designing optimal approaches for selective perturbation and intervention. Deterministic sensitivity analysis techniques, using derivatives of the system response, have been extensively used in the literature. However, these techniques suffer from several drawbacks, which must be carefully considered before using them in problems of systems biology. We develop here a probabilistic approach to sensitivity analysis of biochemical reaction systems. The proposed technique employs a biophysically derived model for parameter fluctuations and, by using a recently suggested variance-based approach to sensitivity analysis [Saltelli et al., Chem. Rev. (Washington, D.C.) 105, 2811 (2005)], it leads to a powerful sensitivity analysis methodology for biochemical reaction systems. The approach presented in this paper addresses many problems associated with derivative-based sensitivity analysis techniques. Most importantly, it produces thermodynamically consistent sensitivity analysis results, can easily accommodate appreciable parameter variations, and allows for systematic investigation of high-order interaction effects. By employing a computational model of the mitogen-activated protein kinase signaling cascade, we demonstrate that our approach is well suited for sensitivity analysis of biochemical reaction systems and can produce a wealth of information about the sensitivity properties of such systems. The price to be paid, however, is a substantial increase in computational complexity over derivative-based techniques, which must be effectively addressed in order to make the proposed approach to sensitivity analysis more practical.

  6. Stochastic analysis of biochemical systems

    CERN Document Server

    Anderson, David F

    2015-01-01

    This book focuses on counting processes and continuous-time Markov chains motivated by examples and applications drawn from chemical networks in systems biology.  The book should serve well as a supplement for courses in probability and stochastic processes.  While the material is presented in a manner most suitable for students who have studied stochastic processes up to and including martingales in continuous time, much of the necessary background material is summarized in the Appendix. Students and Researchers with a solid understanding of calculus, differential equations, and elementary probability and who are well-motivated by the applications will find this book of interest.    David F. Anderson is Associate Professor in the Department of Mathematics at the University of Wisconsin and Thomas G. Kurtz is Emeritus Professor in the Departments of Mathematics and Statistics at that university. Their research is focused on probability and stochastic processes with applications in biology and other ar...

  7. Soft Measurement Modeling Based on Chaos Theory for Biochemical Oxygen Demand (BOD

    Directory of Open Access Journals (Sweden)

    Junfei Qiao

    2016-12-01

    Full Text Available The precision of soft measurement for biochemical oxygen demand (BOD is always restricted due to various factors in the wastewater treatment plant (WWTP. To solve this problem, a new soft measurement modeling method based on chaos theory is proposed and is applied to BOD measurement in this paper. Phase space reconstruction (PSR based on Takens embedding theorem is used to extract more information from the limited datasets of the chaotic system. The WWTP is first testified as a chaotic system by the correlation dimension (D, the largest Lyapunov exponents (λ1, the Kolmogorov entropy (K of the BOD and other water quality parameters time series. Multivariate chaotic time series modeling method with principal component analysis (PCA and artificial neural network (ANN is then adopted to estimate the value of the effluent BOD. Simulation results show that the proposed approach has higher accuracy and better prediction ability than the corresponding modeling approaches not based on chaos theory.

  8. Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory

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    Qian Hong

    2008-05-01

    Full Text Available Abstract Background: Several approaches, including metabolic control analysis (MCA, flux balance analysis (FBA, correlation metric construction (CMC, and biochemical circuit theory (BCT, have been developed for the quantitative analysis of complex biochemical networks. Here, we present a comprehensive theory of linear analysis for nonequilibrium steady-state (NESS biochemical reaction networks that unites these disparate approaches in a common mathematical framework and thermodynamic basis. Results: In this theory a number of relationships between key matrices are introduced: the matrix A obtained in the standard, linear-dynamic-stability analysis of the steady-state can be decomposed as A = SRT where R and S are directly related to the elasticity-coefficient matrix for the fluxes and chemical potentials in MCA, respectively; the control-coefficients for the fluxes and chemical potentials can be written in terms of RT BS and ST BS respectively where matrix B is the inverse of A; the matrix S is precisely the stoichiometric matrix in FBA; and the matrix eAt plays a central role in CMC. Conclusion: One key finding that emerges from this analysis is that the well-known summation theorems in MCA take different forms depending on whether metabolic steady-state is maintained by flux injection or concentration clamping. We demonstrate that if rate-limiting steps exist in a biochemical pathway, they are the steps with smallest biochemical conductances and largest flux control-coefficients. We hypothesize that biochemical networks for cellular signaling have a different strategy for minimizing energy waste and being efficient than do biochemical networks for biosynthesis. We also discuss the intimate relationship between MCA and biochemical systems analysis (BSA.

  9. Final Technical Report "Multiscale Simulation Algorithms for Biochemical Systems"

    Energy Technology Data Exchange (ETDEWEB)

    Petzold, Linda R.

    2012-10-25

    Biochemical systems are inherently multiscale and stochastic. In microscopic systems formed by living cells, the small numbers of reactant molecules can result in dynamical behavior that is discrete and stochastic rather than continuous and deterministic. An analysis tool that respects these dynamical characteristics is the stochastic simulation algorithm (SSA, Gillespie, 1976), a numerical simulation procedure that is essentially exact for chemical systems that are spatially homogeneous or well stirred. Despite recent improvements, as a procedure that simulates every reaction event, the SSA is necessarily inefficient for most realistic problems. There are two main reasons for this, both arising from the multiscale nature of the underlying problem: (1) stiffness, i.e. the presence of multiple timescales, the fastest of which are stable; and (2) the need to include in the simulation both species that are present in relatively small quantities and should be modeled by a discrete stochastic process, and species that are present in larger quantities and are more efficiently modeled by a deterministic differential equation (or at some scale in between). This project has focused on the development of fast and adaptive algorithms, and the fun- damental theory upon which they must be based, for the multiscale simulation of biochemical systems. Areas addressed by this project include: (1) Theoretical and practical foundations for ac- celerated discrete stochastic simulation (tau-leaping); (2) Dealing with stiffness (fast reactions) in an efficient and well-justified manner in discrete stochastic simulation; (3) Development of adaptive multiscale algorithms for spatially homogeneous discrete stochastic simulation; (4) Development of high-performance SSA algorithms.

  10. Systems Theory in Immunology

    CERN Document Server

    Doria, Gino; Koch, Giorgio; Strom, Roberto

    1979-01-01

    This volume collects the contributions presented at the "Working Conference on System Theory in Immunology", held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied mathematics on the other, in order to identify problems of common interest and to establish a network of joint effort toward their solution. The methodologies of system theory for processing experimental data and for describing dynamical phenomena could indeed contribute significantly to the under­ standing of basic immunological facts. Conversely, the complexity of experimental results and of interpretative models should stimulate mathematicians to formulate new problems and to design appropriate procedures of analysis. The multitude of scientific publications in theoretical biology, appeared in recent years, confirms this trend and calls for extensive interaction between mat- matics and immunology. The material of this volume is divided into five sections, along ...

  11. Predictive hypotheses are ineffectual in resolving complex biochemical systems.

    Science.gov (United States)

    Fry, Michael

    2018-03-20

    Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical basis was unclear, hypotheses were only partially effective and supplementary experimentation was required for its conclusive definition. Markedly, hypotheses were entirely inept in predicting workings of complex systems that included unknown elements. Thus, hypotheses did not predict the existence and function of mRNA, the multiple unidentified components of the protein biosynthesis machinery, or the manifold unknown constituents of the ubiquitin-proteasome system of protein breakdown. Consequently, because of their inability to envision unknown entities, predictive hypotheses did not contribute to the elucidation of cation theories remained the sole instrument to explain complex bio-molecular systems, the philosophical question of alleged advantage of predictive over accommodative hypotheses became inconsequential.

  12. Nonlinear stochastic dynamics of mesoscopic homogeneous biochemical reaction systems—an analytical theory

    Science.gov (United States)

    Qian, Hong

    2011-06-01

    The nonlinear dynamics of biochemical reactions in a small-sized system on the order of a cell are stochastic. Assuming spatial homogeneity, the populations of n molecular species follow a multi-dimensional birth-and-death process on {Z}^n . We introduce the Delbrück-Gillespie process, a continuous-time Markov jump process, whose Kolmogorov forward equation has been known as the chemical master equation, and whose stochastic trajectories can be computed via the Gillespie algorithm. Using simple models, we illustrate that a system of nonlinear ordinary differential equations on {R}^n emerges in the infinite system size limit. For finite system size, transitions among multiple attractors of the nonlinear dynamical system are rare events with exponentially long transit times. There is a separation of time scales between the deterministic ODEs and the stochastic Markov jumps between attractors. No diffusion process can provide a global representation that is accurate on both short and long time scales for the nonlinear, stochastic population dynamics. On the short time scale and near deterministic stable fixed points, Ornstein-Uhlenbeck Gaussian processes give linear stochastic dynamics that exhibit time-irreversible circular motion for open, driven chemical systems. Extending this individual stochastic behaviour-based nonlinear population theory of molecular species to other biological systems is discussed.

  13. Applied multidimensional systems theory

    CERN Document Server

    Bose, Nirmal K

    2017-01-01

    Revised and updated, this concise new edition of the pioneering book on multidimensional signal processing is ideal for a new generation of students. Multidimensional systems or m-D systems are the necessary mathematical background for modern digital image processing with applications in biomedicine, X-ray technology and satellite communications. Serving as a firm basis for graduate engineering students and researchers seeking applications in mathematical theories, this edition eschews detailed mathematical theory not useful to students. Presentation of the theory has been revised to make it more readable for students, and introduce some new topics that are emerging as multidimensional DSP topics in the interdisciplinary fields of image processing. New topics include Groebner bases, wavelets, and filter banks.

  14. Design Theory in Information Systems

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    Shirley Gregor

    2002-11-01

    Full Text Available The aim of this paper is to explore an important category of information systems knowledge that is termed “design theory”. This knowledge is distinguished as the fifth of five types of theory: (i theory for analysing and describing, (ii theory for understanding, (iii theory for predicting, (iv theory for explaining and predicting, and (v theory for design and action. Examples of design theory in information systems are provided, with associated research methods. The limited understanding and recognition of this type of theory in information systems indicates that further debate concerning its nature and role in our discipline is needed.

  15. Applied systems theory

    CERN Document Server

    Dekkers, Rob

    2017-01-01

    Offering an up-to-date account of systems theories and its applications, this book provides a different way of resolving problems and addressing challenges in a swift and practical way, without losing overview and grip on the details. From this perspective, it offers a different way of thinking in order to incorporate different perspectives and to consider multiple aspects of any given problem. Drawing examples from a wide range of disciplines, it also presents worked cases to illustrate the principles. The multidisciplinary perspective and the formal approach to modelling of systems and processes of ‘Applied Systems Theory’ makes it suitable for managers, engineers, students, researchers, academics and professionals from a wide range of disciplines; they can use this ‘toolbox’ for describing, analysing and designing biological, engineering and organisational systems as well as getting a better understanding of societal problems. This revised, updated and expanded second edition includes coverage of a...

  16. Biochemical markers predictive for bone marrow involvement in systemic mastocytosis

    NARCIS (Netherlands)

    Donker, Marjolein L.; van Doormaal, Jasper J.; van Doormaal, Frederiek F.; Kluin, Philip M.; van der Veer, Eveline; de Monchy, Jan G. R.; Kema, Ido P.; Kluin-Nelemans, Hanneke C.

    2008-01-01

    Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic

  17. Biochemical markers predictive for bone marrow involvement in systemic mastocytosis

    NARCIS (Netherlands)

    Donker, Marjolein L.; van Doormaal, Jasper J.; van Doormaal, Frederiek F.; Kluin, Philip M.; van der Veer, Eveline; de Monchy, Jan G. R.; Kema, Ido P.; Kluin-Nelemans, Hanneke C.

    Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic

  18. Applied systems theory

    CERN Document Server

    Dekkers, Rob

    2014-01-01

    Offering an up-to-date account of systems theories and its applications, this book provides a different way of resolving problems and addressing challenges in a swift and practical way, without losing overview and not having a grip on the details. From this perspective, it offers a different way of thinking in order to incorporate different perspectives and to consider multiple aspects of any given problem. Drawing examples from a wide range of disciplines, it also presents worked cases to illustrate the principles. The multidisciplinary perspective and the formal approach to modelling of syst

  19. Automated optical sensing system for biochemical assays

    Science.gov (United States)

    Oroszlan, Peter; Duveneck, Gert L.; Ehrat, Markus; Widmer, H. M.

    1994-03-01

    In this paper, we present a new system called FOBIA that was developed and optimized with respect to automated operation of repetitive assay cycles with regenerable bioaffinity sensors. The reliability and precision of the new system is demonstrated by an application in a competitive assay for the detection of the triazine herbicide Atrazine. Using one sensor in more than 300 repetitive cycles, a signal precision better than 5% was achieved.

  20. Systems biology solutions for biochemical production challenges

    DEFF Research Database (Denmark)

    Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus

    2017-01-01

    characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity......There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics...

  1. Thermodynamically consistent Bayesian analysis of closed biochemical reaction systems

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    Goutsias John

    2010-11-01

    Full Text Available Abstract Background Estimating the rate constants of a biochemical reaction system with known stoichiometry from noisy time series measurements of molecular concentrations is an important step for building predictive models of cellular function. Inference techniques currently available in the literature may produce rate constant values that defy necessary constraints imposed by the fundamental laws of thermodynamics. As a result, these techniques may lead to biochemical reaction systems whose concentration dynamics could not possibly occur in nature. Therefore, development of a thermodynamically consistent approach for estimating the rate constants of a biochemical reaction system is highly desirable. Results We introduce a Bayesian analysis approach for computing thermodynamically consistent estimates of the rate constants of a closed biochemical reaction system with known stoichiometry given experimental data. Our method employs an appropriately designed prior probability density function that effectively integrates fundamental biophysical and thermodynamic knowledge into the inference problem. Moreover, it takes into account experimental strategies for collecting informative observations of molecular concentrations through perturbations. The proposed method employs a maximization-expectation-maximization algorithm that provides thermodynamically feasible estimates of the rate constant values and computes appropriate measures of estimation accuracy. We demonstrate various aspects of the proposed method on synthetic data obtained by simulating a subset of a well-known model of the EGF/ERK signaling pathway, and examine its robustness under conditions that violate key assumptions. Software, coded in MATLAB®, which implements all Bayesian analysis techniques discussed in this paper, is available free of charge at http://www.cis.jhu.edu/~goutsias/CSS%20lab/software.html. Conclusions Our approach provides an attractive statistical methodology for

  2. Parametric sensitivity analysis for biochemical reaction networks based on pathwise information theory.

    Science.gov (United States)

    Pantazis, Yannis; Katsoulakis, Markos A; Vlachos, Dionisios G

    2013-10-22

    Stochastic modeling and simulation provide powerful predictive methods for the intrinsic understanding of fundamental mechanisms in complex biochemical networks. Typically, such mathematical models involve networks of coupled jump stochastic processes with a large number of parameters that need to be suitably calibrated against experimental data. In this direction, the parameter sensitivity analysis of reaction networks is an essential mathematical and computational tool, yielding information regarding the robustness and the identifiability of model parameters. However, existing sensitivity analysis approaches such as variants of the finite difference method can have an overwhelming computational cost in models with a high-dimensional parameter space. We develop a sensitivity analysis methodology suitable for complex stochastic reaction networks with a large number of parameters. The proposed approach is based on Information Theory methods and relies on the quantification of information loss due to parameter perturbations between time-series distributions. For this reason, we need to work on path-space, i.e., the set consisting of all stochastic trajectories, hence the proposed approach is referred to as "pathwise". The pathwise sensitivity analysis method is realized by employing the rigorously-derived Relative Entropy Rate, which is directly computable from the propensity functions. A key aspect of the method is that an associated pathwise Fisher Information Matrix (FIM) is defined, which in turn constitutes a gradient-free approach to quantifying parameter sensitivities. The structure of the FIM turns out to be block-diagonal, revealing hidden parameter dependencies and sensitivities in reaction networks. As a gradient-free method, the proposed sensitivity analysis provides a significant advantage when dealing with complex stochastic systems with a large number of parameters. In addition, the knowledge of the structure of the FIM can allow to efficiently address

  3. Intermittency route to chaos in a biochemical system.

    Science.gov (United States)

    De la Fuente, I M; Martinez, L; Veguillas, J

    1996-01-01

    The numerical analysis of a glycolytic model performed through the construction of a system of three differential-delay equations reveals a phenomenon of intermittency route to chaos. In our biochemical system, the consideration of delay time variations under constant input flux as well as frequency variations of the periodic substrate input flux allows us, in both cases, to observe a type of transition to chaos different from the 'Feigenbaum route'.

  4. Information systems theory

    CERN Document Server

    Dwivedi, Yogesh K; Schneberger, Scott L

    2011-01-01

    The overall mission of this book is to provide a comprehensive understanding and coverage of the various theories and models used in IS research. Specifically, it aims to focus on the following key objectives: To describe the various theories and models applicable to studying IS/IT management issues. To outline and describe, for each of the various theories and models, independent and dependent constructs, reference discipline/originating area, originating author(s), seminal articles, level of analysis (i.e. firm, individual, industry) and links with other theories. To provide a critical revie

  5. Accelerated maximum likelihood parameter estimation for stochastic biochemical systems

    Directory of Open Access Journals (Sweden)

    Daigle Bernie J

    2012-05-01

    Full Text Available Abstract Background A prerequisite for the mechanistic simulation of a biochemical system is detailed knowledge of its kinetic parameters. Despite recent experimental advances, the estimation of unknown parameter values from observed data is still a bottleneck for obtaining accurate simulation results. Many methods exist for parameter estimation in deterministic biochemical systems; methods for discrete stochastic systems are less well developed. Given the probabilistic nature of stochastic biochemical models, a natural approach is to choose parameter values that maximize the probability of the observed data with respect to the unknown parameters, a.k.a. the maximum likelihood parameter estimates (MLEs. MLE computation for all but the simplest models requires the simulation of many system trajectories that are consistent with experimental data. For models with unknown parameters, this presents a computational challenge, as the generation of consistent trajectories can be an extremely rare occurrence. Results We have developed Monte Carlo Expectation-Maximization with Modified Cross-Entropy Method (MCEM2: an accelerated method for calculating MLEs that combines advances in rare event simulation with a computationally efficient version of the Monte Carlo expectation-maximization (MCEM algorithm. Our method requires no prior knowledge regarding parameter values, and it automatically provides a multivariate parameter uncertainty estimate. We applied the method to five stochastic systems of increasing complexity, progressing from an analytically tractable pure-birth model to a computationally demanding model of yeast-polarization. Our results demonstrate that MCEM2 substantially accelerates MLE computation on all tested models when compared to a stand-alone version of MCEM. Additionally, we show how our method identifies parameter values for certain classes of models more accurately than two recently proposed computationally efficient methods

  6. Stochastic chemical kinetics theory and (mostly) systems biological applications

    CERN Document Server

    Érdi, Péter; Lente, Gabor

    2014-01-01

    This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.

  7. Modelling biochemical reaction systems by stochastic differential equations with reflection.

    Science.gov (United States)

    Niu, Yuanling; Burrage, Kevin; Chen, Luonan

    2016-05-07

    In this paper, we gave a new framework for modelling and simulating biochemical reaction systems by stochastic differential equations with reflection not in a heuristic way but in a mathematical way. The model is computationally efficient compared with the discrete-state Markov chain approach, and it ensures that both analytic and numerical solutions remain in a biologically plausible region. Specifically, our model mathematically ensures that species numbers lie in the domain D, which is a physical constraint for biochemical reactions, in contrast to the previous models. The domain D is actually obtained according to the structure of the corresponding chemical Langevin equations, i.e., the boundary is inherent in the biochemical reaction system. A variant of projection method was employed to solve the reflected stochastic differential equation model, and it includes three simple steps, i.e., Euler-Maruyama method was applied to the equations first, and then check whether or not the point lies within the domain D, and if not perform an orthogonal projection. It is found that the projection onto the closure D¯ is the solution to a convex quadratic programming problem. Thus, existing methods for the convex quadratic programming problem can be employed for the orthogonal projection map. Numerical tests on several important problems in biological systems confirmed the efficiency and accuracy of this approach. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Information theory of molecular systems

    CERN Document Server

    Nalewajski, Roman F

    2006-01-01

    As well as providing a unified outlook on physics, Information Theory (IT) has numerous applications in chemistry and biology owing to its ability to provide a measure of the entropy/information contained within probability distributions and criteria of their information ""distance"" (similarity) and independence. Information Theory of Molecular Systems applies standard IT to classical problems in the theory of electronic structure and chemical reactivity. The book starts by introducing the basic concepts of modern electronic structure/reactivity theory based upon the Density Functional Theory

  9. BIOCHEMICAL PROCESSES IN CHERNOZEM SOIL UNDER DIFFERENT FERTILIZATION SYSTEMS

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    Ecaterina Emnova

    2012-06-01

    Full Text Available The paper deals with the evaluation of the intensity of certain soil biochemical processes (e.g. soil organic C mineralization at Organic and mixed Mineral+Organic fertilization of typical chernozem in crop rotation dynamics (for 6 years by use of eco-physiological indicators of biological soil quality: microbial biomass carbon, basal soil respiration, as well as, microbial and metabolic quotients. Soil sampling was performed from a long-term field crop experiment, which has been established in 1971 at the Balti steppe (Northern Moldova. The crop types had a more considerable impact on the soil microbial biomass accumulation and community biochemical activity compared to long-term Organic or mixed Mineral + Organic fertilizers amendments. The Org fertilization system doesn’t make it possible to avoid the loss of organic C in arable typical chernozem. The organic fertilizer (cattle manure is able to mitigate the negative consequences of long-term mineral fertilization.

  10. Ergodic theory and dynamical systems

    CERN Document Server

    Coudène, Yves

    2016-01-01

    This textbook is a self-contained and easy-to-read introduction to ergodic theory and the theory of dynamical systems, with a particular emphasis on chaotic dynamics. This book contains a broad selection of topics and explores the fundamental ideas of the subject. Starting with basic notions such as ergodicity, mixing, and isomorphisms of dynamical systems, the book then focuses on several chaotic transformations with hyperbolic dynamics, before moving on to topics such as entropy, information theory, ergodic decomposition and measurable partitions. Detailed explanations are accompanied by numerous examples, including interval maps, Bernoulli shifts, toral endomorphisms, geodesic flow on negatively curved manifolds, Morse-Smale systems, rational maps on the Riemann sphere and strange attractors. Ergodic Theory and Dynamical Systems will appeal to graduate students as well as researchers looking for an introduction to the subject. While gentle on the beginning student, the book also contains a number of commen...

  11. Estimating rare events in biochemical systems using conditional sampling

    Science.gov (United States)

    Sundar, V. S.

    2017-01-01

    The paper focuses on development of variance reduction strategies to estimate rare events in biochemical systems. Obtaining this probability using brute force Monte Carlo simulations in conjunction with the stochastic simulation algorithm (Gillespie's method) is computationally prohibitive. To circumvent this, important sampling tools such as the weighted stochastic simulation algorithm and the doubly weighted stochastic simulation algorithm have been proposed. However, these strategies require an additional step of determining the important region to sample from, which is not straightforward for most of the problems. In this paper, we apply the subset simulation method, developed as a variance reduction tool in the context of structural engineering, to the problem of rare event estimation in biochemical systems. The main idea is that the rare event probability is expressed as a product of more frequent conditional probabilities. These conditional probabilities are estimated with high accuracy using Monte Carlo simulations, specifically the Markov chain Monte Carlo method with the modified Metropolis-Hastings algorithm. Generating sample realizations of the state vector using the stochastic simulation algorithm is viewed as mapping the discrete-state continuous-time random process to the standard normal random variable vector. This viewpoint opens up the possibility of applying more sophisticated and efficient sampling schemes developed elsewhere to problems in stochastic chemical kinetics. The results obtained using the subset simulation method are compared with existing variance reduction strategies for a few benchmark problems, and a satisfactory improvement in computational time is demonstrated.

  12. Improved methods for the mathematically controlled comparison of biochemical systems

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    Schwacke John H

    2004-06-01

    Full Text Available Abstract The method of mathematically controlled comparison provides a structured approach for the comparison of alternative biochemical pathways with respect to selected functional effectiveness measures. Under this approach, alternative implementations of a biochemical pathway are modeled mathematically, forced to be equivalent through the application of selected constraints, and compared with respect to selected functional effectiveness measures. While the method has been applied successfully in a variety of studies, we offer recommendations for improvements to the method that (1 relax requirements for definition of constraints sufficient to remove all degrees of freedom in forming the equivalent alternative, (2 facilitate generalization of the results thus avoiding the need to condition those findings on the selected constraints, and (3 provide additional insights into the effect of selected constraints on the functional effectiveness measures. We present improvements to the method and related statistical models, apply the method to a previously conducted comparison of network regulation in the immune system, and compare our results to those previously reported.

  13. Decision Support Systems: Theory.

    Science.gov (United States)

    1976-01-01

    What situations make a DSS comfortable or uncomfort- able? These are improtant research areas, even though they are often over- looked. For example...Fall Conferences, American Marketing Association, pp. 163-167 , 1971. Boshell, E. 0., "Operations Research , Top Management Tool, " Dun’s Review and...Conference Sponsored by the Center for Information Systems Research , M. I. T., April 3-5, 1975. Kegerreis, Robert, " Marketing Management and the Computer

  14. General Systems Theory and Instructional Systems Design.

    Science.gov (United States)

    Salisbury, David F.

    1990-01-01

    Describes basic concepts in the field of general systems theory (GST) and identifies commonalities that exist between GST and instructional systems design (ISD). Models and diagrams that depict system elements in ISD are presented, and two matrices that show how GST has been used in ISD literature are included. (11 references) (LRW)

  15. Kinetic Theory of Dynamical Systems

    NARCIS (Netherlands)

    Zon, R. van; Beijeren, H. van; Dorfman, J.R.

    1999-01-01

    It is generally believed that the dynamics of simple fluids can be considered to be chaotic, at least to the extent that they can be modeled as classical systems of particles interacting with short range, repulsive forces. Here we give a brief introduction to those parts of chaos theory that are

  16. Gestalt Therapy and General System Theory.

    Science.gov (United States)

    Whitner, Phillip A.

    While General Systems Theory (GST) concepts appear to be applicable in explaining some of the phenomena that occur in a Gestalt Therapy group, research is needed to support this assumption. General Systems Theory may not be a group theory per se. Instead, GST may be a theory about groups. A meta-theory exists where its value and usefulness is…

  17. Biochemical oxygen demand measurement by mediator method in flow system.

    Science.gov (United States)

    Liu, Ling; Bai, Lu; Yu, Dengbin; Zhai, Junfeng; Dong, Shaojun

    2015-06-01

    Using mediator as electron acceptor for biochemical oxygen demand (BOD) measurement was developed in the last decade (BODMed). However, until now, no BOD(Med) in a flow system has been reported. This work for the first time describes a flow system of BOD(Med) method (BOD(Med)-FS) by using potassium ferricyanide as mediator and carbon fiber felt as substrate material for microbial immobilization. The system can determine the BOD value within 30 min and possesses a wider analytical linear range for measuring glucose-glutamic acid (GGA) standard solution from 2 up to 200 mg L(-1) without the need of dilution. The analytical performance of the BOD(Med)-FS is comparable or better than that of the previously reported BOD(Med) method, especially its superior long-term stability up to 2 months under continuous operation. Moreover, the BOD(Med)-FS has same determination accuracy with the conventional BOD5 method by measuring real samples from a local wastewater treatment plant (WWTP). Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Systems Theory and Systems Approach to Leadership

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Berim Ramosaj

    2014-06-01

    Full Text Available Systems theory is product of the efforts of many researchers to create an intermediate field of coexistence of all sciences. If not for anything else, because of the magnitude that the use of systemic thinking and systemic approach has taken, it has become undisputed among the theories. Systems theory not only provides a glossary of terms with which researchers from different fields can be understood, but provides a framework for the presentation and interpretation of phenomena and realities. This paper addresses a systematic approach to leadership, as an attempt to dredge leadership and systems theory literature to find the meeting point. Systems approach is not an approach to leadership in terms of a manner of leader’s work, but it’s the leader's determination to factorize in his leadership the external environment and relationships with and among elements. Leader without followers is unable to exercise his leadership and to ensure their conviction he should provide a system, a structure, a purpose, despite the alternative chaos. Systems approach clarifies the thought on the complexity and dynamism of the environment and provides a framework for building ideas. If the general system theory is the skeleton of science (Boulding: 1956, this article aims to replenish it with leadership muscles by prominent authors who have written on systems theory and leadership, as well as through original ideas. In this work analytical methods were used (by analyzing approaches individually as well as synthetic methods (by assaying individual approaches in context of entirety. The work is a critical review of literature as well as a deductive analysis mingled with models proposed by authors through inductive analysis. Meta-analysis has been used to dissect the interaction and interdependence between leadership approaches.

  19. Trends in modern system theory

    Science.gov (United States)

    Athans, M.

    1976-01-01

    The topics considered are related to linear control system design, adaptive control, failure detection, control under failure, system reliability, and large-scale systems and decentralized control. It is pointed out that the design of a linear feedback control system which regulates a process about a desirable set point or steady-state condition in the presence of disturbances is a very important problem. The linearized dynamics of the process are used for design purposes. The typical linear-quadratic design involving the solution of the optimal control problem of a linear time-invariant system with respect to a quadratic performance criterion is considered along with gain reduction theorems and the multivariable phase margin theorem. The stumbling block in many adaptive design methodologies is associated with the amount of real time computation which is necessary. Attention is also given to the desperate need to develop good theories for large-scale systems, the beginning of a microprocessor revolution, the translation of the Wiener-Hopf theory into the time domain, and advances made in dynamic team theory, dynamic stochastic games, and finite memory stochastic control.

  20. A second-order, unconditionally positive, mass-conserving integration scheme for biochemical systems.

    NARCIS (Netherlands)

    F.J. Bruggeman (Frank); H. Burchard; B. Kooi; B.P. Sommeijer (Ben)

    2006-01-01

    textabstractBiochemical systems are bound by two mathematically-relevant restrictions. First, state variables in such systems represent non-negative quantities, such as concentrations of chemical compounds. Second, biochemical systems conserve mass and energy. Both properties must be reflected in

  1. Systemic Thinking in Career Development Theory: Contributions of the Systems Theory Framework

    Science.gov (United States)

    McMahon, Mary; Patton, Wendy

    2018-01-01

    This article considers systemic thinking in relation to the Systems Theory Framework (STF) and to career theory. An overview of systems theory and its applications is followed by a discussion of career theory to provide a context for the subsequent description of STF. The contributions of STF to career theory and to theory integration are…

  2. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems.

    Science.gov (United States)

    Lomnitz, Jason G; Savageau, Michael A

    2016-08-31

    An overarching goal in molecular biology is to gain an understanding of the mechanistic basis underlying biochemical systems. Success is critical if we are to predict effectively the outcome of drug treatments and the development of abnormal phenotypes. However, data from most experimental studies is typically noisy and sparse. This allows multiple potential mechanisms to account for experimental observations, and often devising experiments to test each is not feasible. Here, we introduce a novel strategy that discriminates among putative models based on their repertoire of qualitatively distinct phenotypes, without relying on knowledge of specific values for rate constants and binding constants. As an illustration, we apply this strategy to two synthetic gene circuits exhibiting anomalous behaviors. Our results show that the conventional models, based on their well-characterized components, cannot account for the experimental observations. We examine a total of 40 alternative hypotheses and show that only 5 have the potential to reproduce the experimental data, and one can do so with biologically relevant parameter values.

  3. Dynamical systems V bifurcation theory and catastrophe theory

    CERN Document Server

    1994-01-01

    Bifurcation theory and catastrophe theory are two of the best known areas within the field of dynamical systems. Both are studies of smooth systems, focusing on properties that seem to be manifestly non-smooth. Bifurcation theory is concerned with the sudden changes that occur in a system when one or more parameters are varied. Examples of such are familiar to students of differential equations, from phase portraits. Moreover, understanding the bifurcations of the differential equations that describe real physical systems provides important information about the behavior of the systems. Catastrophe theory became quite famous during the 1970's, mostly because of the sensation caused by the usually less than rigorous applications of its principal ideas to "hot topics", such as the characterization of personalities and the difference between a "genius" and a "maniac". Catastrophe theory is accurately described as singularity theory and its (genuine) applications. The authors of this book, the first printing of w...

  4. Hierarchical graphs for rule-based modeling of biochemical systems

    Directory of Open Access Journals (Sweden)

    Hu Bin

    2011-02-01

    Full Text Available Abstract Background In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state of a component, and an edge represents a bond between components. Components of a molecule share the same color. Furthermore, graph-rewriting rules are used to represent molecular interactions. A rule that specifies addition (removal of an edge represents a class of association (dissociation reactions, and a rule that specifies a change of a vertex attribute represents a class of reactions that affect the internal state of a molecular component. A set of rules comprises an executable model that can be used to determine, through various means, the system-level dynamics of molecular interactions in a biochemical system. Results For purposes of model annotation, we propose the use of hierarchical graphs to represent structural relationships among components and subcomponents of molecules. We illustrate how hierarchical graphs can be used to naturally document the structural organization of the functional components and subcomponents of two proteins: the protein tyrosine kinase Lck and the T cell receptor (TCR complex. We also show that computational methods developed for regular graphs can be applied to hierarchical graphs. In particular, we describe a generalization of Nauty, a graph isomorphism and canonical labeling algorithm. The generalized version of the Nauty procedure, which we call HNauty, can be used to assign canonical labels to hierarchical graphs or more generally to graphs with multiple edge types. The difference between the Nauty and HNauty procedures is minor, but for completeness, we provide an explanation of the entire HNauty algorithm. Conclusions Hierarchical graphs provide more intuitive formal representations of proteins and other structured molecules with multiple functional components than do the regular graphs of current languages for

  5. Hierarchical graphs for rule-based modeling of biochemical systems.

    Science.gov (United States)

    Lemons, Nathan W; Hu, Bin; Hlavacek, William S

    2011-02-02

    In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state of a component, and an edge represents a bond between components. Components of a molecule share the same color. Furthermore, graph-rewriting rules are used to represent molecular interactions. A rule that specifies addition (removal) of an edge represents a class of association (dissociation) reactions, and a rule that specifies a change of a vertex attribute represents a class of reactions that affect the internal state of a molecular component. A set of rules comprises an executable model that can be used to determine, through various means, the system-level dynamics of molecular interactions in a biochemical system. For purposes of model annotation, we propose the use of hierarchical graphs to represent structural relationships among components and subcomponents of molecules. We illustrate how hierarchical graphs can be used to naturally document the structural organization of the functional components and subcomponents of two proteins: the protein tyrosine kinase Lck and the T cell receptor (TCR) complex. We also show that computational methods developed for regular graphs can be applied to hierarchical graphs. In particular, we describe a generalization of Nauty, a graph isomorphism and canonical labeling algorithm. The generalized version of the Nauty procedure, which we call HNauty, can be used to assign canonical labels to hierarchical graphs or more generally to graphs with multiple edge types. The difference between the Nauty and HNauty procedures is minor, but for completeness, we provide an explanation of the entire HNauty algorithm. Hierarchical graphs provide more intuitive formal representations of proteins and other structured molecules with multiple functional components than do the regular graphs of current languages for specifying rule-based models, such as the BioNetGen language

  6. Language theory and expert systems

    Directory of Open Access Journals (Sweden)

    Attilio Agodi

    1988-11-01

    Full Text Available Some remarks on the problem of knowledge representation and processing, as recognized in connection with the use of computers in the scientific research work, emphasizes the relevance of these problems for the studies on both the theory of languages and the expert system. A consideration of the common traits in the recent history of these studies, with reference to the use of computers on texts in natural language motivates the introduction of set theoretic and algebraic methods, suitable for applications in the analysis and in the automatic treatment of languages, based on the concept of model sets and on relational structures suggested from the connections between syntax and semantics evidenced in some example of sub-languages corresponding to theories of different classes of physical phenomena. Some details of these methods are evidenced, which have already successfully used or whose applications appears suggestive of interesting development.

  7. Biochemical System Analysis of Lutein Production by Heterotrophic Chlorella pyrenoidosa in a Fermentor

    Directory of Open Access Journals (Sweden)

    Zheng-Yun Wu

    2009-01-01

    Full Text Available Chlorella is a promising alternative source of lutein, as it can be cultivated heterotrophically with high efficiency. In this study, the carotenoids in Chlorella pyrenoidosa heterotrophically cultivated in a 19-litre fermentor have been analyzed and determined by using HPLC and HPLC-MS. A biochemical system theory (BST model was developed for understanding the regulatory features of carotenoid metabolism during the batch cultivation. Factors that influence lutein production by C. pyrenoidosa were discussed based on the model. It shows that low flux for lycopene formation is the major bottleneck for lutein production, while by-product syntheses and inhibitions affect the cellular lutein content much less. However, with further increase of the cellular lutein content, the inhibition on lycopene formation by lutein may become a limiting factor. Although speculative, these results may provide useful information for further elucidation of the regulatory mechanisms of carotenoid biosynthesis in Chlorella and modifying its metabolic network to enhance lutein production.

  8. Scheduling theory, algorithms, and systems

    CERN Document Server

    Pinedo, Michael L

    2016-01-01

    This new edition of the well-established text Scheduling: Theory, Algorithms, and Systems provides an up-to-date coverage of important theoretical models in the scheduling literature as well as important scheduling problems that appear in the real world. The accompanying website includes supplementary material in the form of slide-shows from industry as well as movies that show actual implementations of scheduling systems. The main structure of the book, as per previous editions, consists of three parts. The first part focuses on deterministic scheduling and the related combinatorial problems. The second part covers probabilistic scheduling models; in this part it is assumed that processing times and other problem data are random and not known in advance. The third part deals with scheduling in practice; it covers heuristics that are popular with practitioners and discusses system design and implementation issues. All three parts of this new edition have been revamped, streamlined, and extended. The reference...

  9. Physical Theory of the Immune System

    Science.gov (United States)

    Deem, Michael

    2012-10-01

    I will discuss to theories of the immune system and describe a theory of the immune response to vaccines. I will illustrate this theory by application to design of the annual influenza vaccine. I will use this theory to explain limitations in the vaccine for dengue fever and to suggest a transport-inspired amelioration of these limitations.

  10. The Systems Theory of Autistogenesis

    Directory of Open Access Journals (Sweden)

    J. Patrick Malone

    2012-04-01

    Full Text Available The systems theory of autistogenesis accounts for genetic and environmental predisposing factors for pervasive developmental disorders. During development, regions of the brain myelinate differentially, even while neuroinflammatory events induce neurological damage. Incorrect dietary ratios of docosahexaenoic acid (DHA to arachidonic acid (AA promote developmental aberration characteristic of autism spectrum disorders (ASD, and commercial infant formulae possesses DHA/AA ratios unsuitable for normal brain development in those predisposed. The aromatase gene regulates DHA/AA metabolism and represents a potential biomarker for ASD. Aromatase converts testosterone to estradiol. Estradiol is neuroprotective and a modulator of oxytocin receptors deficient in autism. Neuroprotective DHA is not well synthesized in males and is regulated by estradiol. Therefore, converging evidence indicates that any disturbance to the autistogenic system linking environment to neurobiology and genetics is capable of inducing developmental disorders with gender disparity.

  11. Linear response theory for quantum open systems

    OpenAIRE

    Wei, J. H.; Yan, YiJing

    2011-01-01

    Basing on the theory of Feynman's influence functional and its hierarchical equations of motion, we develop a linear response theory for quantum open systems. Our theory provides an effective way to calculate dynamical observables of a quantum open system at its steady-state, which can be applied to various fields of non-equilibrium condensed matter physics.

  12. Developing Systemic Theories Requires Formal Methods

    Science.gov (United States)

    Gobet, Fernand

    2012-01-01

    Ziegler and Phillipson (Z&P) advance an interesting and ambitious proposal, whereby current analytical/mechanistic theories of gifted education are replaced by systemic theories. In this commentary, the author focuses on the pros and cons of using systemic theories. He argues that Z&P's proposal both goes too far and not far enough. The future of…

  13. Medium Theory and Social Systems

    DEFF Research Database (Denmark)

    Tække, Jesper

    The  paper  first  gives  a  tentative  theoretical  explanation  of  the  concept  of media,  based  on  the  dichotomies  of  actual/potential  (meaning),  form/medium  (appearance),  and  substratum/material  content  (extension  in  time  and  space).  This  theoretical  explanation  presents......  seen as medium  for  formation. Finally  the  paper  takes  the micro  level  perspective  by  applying  the  theory  to  newsgroups,  interpreting  them as self-organizing interactive systems giving a differentiated and diversified scope for social  inclusion.  ......The  paper  first  gives  a  tentative  theoretical  explanation  of  the  concept  of media,  based  on  the  dichotomies  of  actual/potential  (meaning),  form/medium  (appearance),  and  substratum/material  content  (extension  in  time  and  space).  This  theoretical  explanation  presents......  the  possibility  for  observation both of a social micro and a social macro level from a medium perspective. In the next  section  the paper  frames  the macro  level by  a  tentative  synthesis of  the medium  theory  and  the  sociological systems theory briefly describing a socio...

  14. Fibre optic system for biochemical and microbiological sensing

    International Nuclear Information System (INIS)

    Penwill, L A; Slater, J H; Hayes, N W; Tremlett, C J

    2007-01-01

    This poster will discuss state-of-the-art fibre optic sensors based on evanescent wave technology emphasising chemophotonic sensors for biochemical reactions and microbe detection. Devices based on antibody specificity and unique DNA sequences will be described. The development of simple sensor devices with disposable single use sensor probes will be illustrated with a view to providing cost effective field based or point of care analysis of major themes such as hospital acquired infections or bioterrorism events. This presentation will discuss the nature and detection thresholds required, the optical detection techniques investigated, results of sensor trials and the potential for wider commercial application

  15. General Systems Theory and Instructional Design.

    Science.gov (United States)

    Salisbury, David F.

    The use of general systems theory in the field of instructional systems design (ISD) is explored in this paper. Drawing on work by Young, the writings of 12 representative ISD writers and researchers were surveyed to determine the use of 60 general systems theory concepts by the individual authors. The average number of concepts used by these…

  16. Perturbation theory of large quantum systems

    NARCIS (Netherlands)

    Hugenholtz, N.M.

    1957-01-01

    The time-independent perturbation theory of quantum mechanics is studied for the case of very large systems, i.e. systems with large spatial dimensions (large volume Ω), and a large number of degrees of freedom. Examples of such systems are met with in the quantum theory of fields, solid state

  17. Reachability in Biochemical Dynamical Systems by Quantitative Discrete Approximation (extended abstract

    Directory of Open Access Journals (Sweden)

    L. Brim

    2011-09-01

    Full Text Available In this paper, a novel computational technique for finite discrete approximation of continuous dynamical systems suitable for a significant class of biochemical dynamical systems is introduced. The method is parameterized in order to affect the imposed level of approximation provided that with increasing parameter value the approximation converges to the original continuous system. By employing this approximation technique, we present algorithms solving the reachability problem for biochemical dynamical systems. The presented method and algorithms are evaluated on several exemplary biological models and on a real case study.

  18. The kinetic theory of open systems

    International Nuclear Information System (INIS)

    Klimontovich, Yu.L.

    2001-01-01

    This paper begins with a survey of recently obtained results in the statistical theory of open systems, including quantum open systems. Then the definition of the thermal flux in the kinetic theory is considered, further the collision nature of the Landau damping. Finally the Lamb shift and Bethe's formula are analyzed. (orig.)

  19. Titchmarsh-Weyl theory for canonical systems

    Directory of Open Access Journals (Sweden)

    Keshav Raj Acharya

    2014-11-01

    Full Text Available The main purpose of this paper is to develop Titchmarsh- Weyl theory of canonical systems. To this end, we first observe the fact that Schrodinger and Jacobi equations can be written into canonical systems. We then discuss the theory of Weyl m-function for canonical systems and establish the relation between the Weyl m-functions of Schrodinger equations and that of canonical systems which involve Schrodinger equations.

  20. Control Systems and Number Theory

    Directory of Open Access Journals (Sweden)

    Fuhuo Li

    2012-01-01

    and PID-controllers are applied successfully in the EV control by J.-Y. Cao and B.-G. Cao 2006 and Cao et al. 2007, which we may unify in our framework. Finally, we mention some similarities between control theory and zeta-functions.

  1. CADLIVE toolbox for MATLAB: automatic dynamic modeling of biochemical networks with comprehensive system analysis.

    Science.gov (United States)

    Inoue, Kentaro; Maeda, Kazuhiro; Miyabe, Takaaki; Matsuoka, Yu; Kurata, Hiroyuki

    2014-09-01

    Mathematical modeling has become a standard technique to understand the dynamics of complex biochemical systems. To promote the modeling, we had developed the CADLIVE dynamic simulator that automatically converted a biochemical map into its associated mathematical model, simulated its dynamic behaviors and analyzed its robustness. To enhance the feasibility by CADLIVE and extend its functions, we propose the CADLIVE toolbox available for MATLAB, which implements not only the existing functions of the CADLIVE dynamic simulator, but also the latest tools including global parameter search methods with robustness analysis. The seamless, bottom-up processes consisting of biochemical network construction, automatic construction of its dynamic model, simulation, optimization, and S-system analysis greatly facilitate dynamic modeling, contributing to the research of systems biology and synthetic biology. This application can be freely downloaded from http://www.cadlive.jp/CADLIVE_MATLAB/ together with an instruction.

  2. Importance theory for lumped-parameter systems

    International Nuclear Information System (INIS)

    Cady, K.B.; Kenton, M.A.; Ward, J.C.; Piepho, M.G.

    1981-01-01

    A general sensitivity theory has been developed for nonlinear lumped parameter system simulations. The point of departure is general perturbation theory for nonlinear systems. Importance theory as developed here allows the calculation of the sensitivity of a response function to any physical or design parameter; importance of any equation or term or physical effect in the system model on the response function; variance of the response function caused by the variances and covariances of all physical parameters; and approximate effect on the response function of missing physical phenomena or incorrect parameters

  3. Using institutional theory in enterprise systems research

    DEFF Research Database (Denmark)

    Svejvig, Per

    2013-01-01

    This paper sets out to examine the use of institutional theory as a conceptually rich lens to study social issues of enterprise systems (ES) research. More precisely, the purpose is to categorize current ES research using institutional theory to develop a conceptual model that advances ES research...

  4. A simplified representation of biochemical principles based on the dynamics of chemical flow systems.

    Science.gov (United States)

    Tienari, J

    1995-06-01

    This work suggests that the amount of information included in biochemistry texts is artificially increased, because the knowledge presented contains tautologies that are obscured by the use of inappropriate methods of representation. The work then proposes alternative methods of representation for describing biochemical systems that are based on the dynamics of an idealized chemical open-flow system. They would clarify the fact, in an open system, the concentrations of the reactants and reaction products depend not only on the equilibrium constants but on the absolute velocities of the reactions as well. Similar rules apply to phenomena involving other processes, such as diffusion of ions. Biochemical systems are considered as a set of chemical flow systems in which individual processes have the potential for interactions if their end products influence the rate of other processes. These interactions are used to explain how biochemical systems maintain themselves in states of high order. By use of these formulations, some of the logical sequences by which biochemical principles can be deduced from the principles of chemistry can be given simple and illustrative expression.

  5. Applications of the Theory of Technical Systems

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup; McAloone, Timothy Charles

    2008-01-01

    This paper uses the development and applications of Hubka’s Theory of Technical Systems (TTS) at DTU as an example of the power of the theory, the necessity of detailing and fitting the theory, and the role of a theory as a basis for research.At the same time the paper is a balance of the influence......-product development. Across all these areas we have created a version of TTS with substantial applicability and coherence. This article does not show details on all of the research projects (which may be found in the literature), but it shows directions taken from Hubka’s TTS and the contributions made in academia...

  6. Biochemical Space: A Framework for Systemic Annotation of Biological Models

    Czech Academy of Sciences Publication Activity Database

    Klement, M.; Děd, T.; Šafránek, D.; Červený, Jan; Müller, Stefan; Steuer, Ralf

    2014-01-01

    Roč. 306, JUL (2014), s. 31-44 ISSN 1571-0661 R&D Projects: GA MŠk(CZ) EE2.3.20.0256 Institutional support: RVO:67179843 Keywords : biological models * model annotation * systems biology * cyanobacteria Subject RIV: EH - Ecology, Behaviour

  7. Nonequilibrium Enhances Adaptation Efficiency of Stochastic Biochemical Systems.

    Directory of Open Access Journals (Sweden)

    Chen Jia

    Full Text Available Adaptation is a crucial biological function possessed by many sensory systems. Early work has shown that some influential equilibrium models can achieve accurate adaptation. However, recent studies indicate that there are close relationships between adaptation and nonequilibrium. In this paper, we provide an explanation of these two seemingly contradictory results based on Markov models with relatively simple networks. We show that as the nonequilibrium driving becomes stronger, the system under consideration will undergo a phase transition along a fixed direction: from non-adaptation to simple adaptation then to oscillatory adaptation, while the transition in the opposite direction is forbidden. This indicates that although adaptation may be observed in equilibrium systems, it tends to occur in systems far away from equilibrium. In addition, we find that nonequilibrium will improve the performance of adaptation by enhancing the adaptation efficiency. All these results provide a deeper insight into the connection between adaptation and nonequilibrium. Finally, we use a more complicated network model of bacterial chemotaxis to validate the main results of this paper.

  8. AN EDUCATIONAL THEORY MODEL--(SIGGS), AN INTEGRATION OF SET THEORY, INFORMATION THEORY, AND GRAPH THEORY WITH GENERAL SYSTEMS THEORY.

    Science.gov (United States)

    MACCIA, ELIZABETH S.; AND OTHERS

    AN ANNOTATED BIBLIOGRAPHY OF 20 ITEMS AND A DISCUSSION OF ITS SIGNIFICANCE WAS PRESENTED TO DESCRIBE CURRENT UTILIZATION OF SUBJECT THEORIES IN THE CONSTRUCTION OF AN EDUCATIONAL THEORY. ALSO, A THEORY MODEL WAS USED TO DEMONSTRATE CONSTRUCTION OF A SCIENTIFIC EDUCATIONAL THEORY. THE THEORY MODEL INCORPORATED SET THEORY (S), INFORMATION THEORY…

  9. Clinical and biochemical landmarks in systemic autoinflammatory diseases.

    Science.gov (United States)

    Cantarini, Luca; Rigante, Donato; Brizi, Maria Giuseppina; Lucherini, Orso Maria; Sebastiani, Gian Domenico; Vitale, Antonio; Gianneramo, Valentina; Galeazzi, Mauro

    2012-11-01

    Systemic autoinflammatory diseases are a group of inherited disorders of the innate immune system characterized by seemingly unprovoked inflammation recurring at variable intervals and involving skin, serosal membranes, joints, and gastrointestinal apparatus, with reactive amyloidosis as a possible severe long-term complication. Recent advances in genetics and molecular biology have improved our understanding of the pathogenesis of these diseases, including familial Mediterranean fever, mevalonate kinase deficiency syndrome, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndromes, and hereditary pyogenic and granulomatous disorders: the vast majority of these conditions are related to the activation of the interleukin-1 pathway, which results in (or from?) a common unifying pathogenetic mechanism. Their diagnostic identification derives from the combination of clinical data, evaluation of acute phase reactants, clinical efficacy in response to specific drugs, and recognition of specific mutations in the relevant genes, although genetic tests may be unconstructive in some cases. This review will discuss clinical and laboratory clues useful for a diagnostic approach to systemic autoinflammatory diseases.

  10. Neurosemantics, neurons and system theory.

    Science.gov (United States)

    Breidbach, Olaf

    2007-08-01

    Following the concept of internal representations, signal processing in a neuronal system has to be evaluated exclusively based on internal system characteristics. Thus, this approach omits the external observer as a control function for sensory integration. Instead, the configuration of the system and its computational performance are the effects of endogenous factors. Such self-referential operation is due to a strictly local computation in a network and, thereby, computations follow a set of rules that constitute the emergent behaviour of the system. These rules can be shown to correspond to a "logic" that is intrinsic to the system, an idea which provides the basis for neurosemantics.

  11. [Design of high-efficiency double compound parabolic concentrator system in near infrared noninvasive biochemical analysis].

    Science.gov (United States)

    Gao, Jing; Lu, Qi-Peng; Peng, Zhong-Qi; Ding, Hai-Quan; Gao, Hong-Zhi

    2013-05-01

    High signal-to-noise ratio (SNR) of system is necessary to obtain accurate blood components in near infrared noninvasive biochemical analysis. In order to improve SNR of analytical system, high-efficiency double compound parabolic concentrator (DCPC) system was researched, which was aimed at increasing light utilization efficiency. Firstly, with the request of collection efficiency in near infrared noninvasive biochemical analysis, the characteristic of emergent rays through compound parabolic concentrator (CPC) was analyzed. Then the maximum focusing angle range of the first stage CPC was determined. Secondly, the light utilization efficiency of truncated type was compared with standard DCPC, thus the best structure parameters of DCPC system were optimized. Lastly, combined with optical parameters of skin tissue, calculations were operated when incident wavelength is 1 000 nm. The light utilization efficiency of DCPC system, CPC-focusing mirror system, and non-optical collecting system was calculated. The results show that the light utilization efficiency of the three optical systems is 1.46%, 0.84% and 0.26% respectively. So DCPC system enhances collecting ability for human diffuse reflection light, and helps improve SNR of noninvasive biochemical analysis system and overall analysis accuracy effectively.

  12. Global parameter estimation methods for stochastic biochemical systems

    Directory of Open Access Journals (Sweden)

    Poovathingal Suresh

    2010-08-01

    Full Text Available Abstract Background The importance of stochasticity in cellular processes having low number of molecules has resulted in the development of stochastic models such as chemical master equation. As in other modelling frameworks, the accompanying rate constants are important for the end-applications like analyzing system properties (e.g. robustness or predicting the effects of genetic perturbations. Prior knowledge of kinetic constants is usually limited and the model identification routine typically includes parameter estimation from experimental data. Although the subject of parameter estimation is well-established for deterministic models, it is not yet routine for the chemical master equation. In addition, recent advances in measurement technology have made the quantification of genetic substrates possible to single molecular levels. Thus, the purpose of this work is to develop practical and effective methods for estimating kinetic model parameters in the chemical master equation and other stochastic models from single cell and cell population experimental data. Results Three parameter estimation methods are proposed based on the maximum likelihood and density function distance, including probability and cumulative density functions. Since stochastic models such as chemical master equations are typically solved using a Monte Carlo approach in which only a finite number of Monte Carlo realizations are computationally practical, specific considerations are given to account for the effect of finite sampling in the histogram binning of the state density functions. Applications to three practical case studies showed that while maximum likelihood method can effectively handle low replicate measurements, the density function distance methods, particularly the cumulative density function distance estimation, are more robust in estimating the parameters with consistently higher accuracy, even for systems showing multimodality. Conclusions The parameter

  13. Hybrid deterministic/stochastic simulation of complex biochemical systems.

    Science.gov (United States)

    Lecca, Paola; Bagagiolo, Fabio; Scarpa, Marina

    2017-11-21

    In a biological cell, cellular functions and the genetic regulatory apparatus are implemented and controlled by complex networks of chemical reactions involving genes, proteins, and enzymes. Accurate computational models are indispensable means for understanding the mechanisms behind the evolution of a complex system, not always explored with wet lab experiments. To serve their purpose, computational models, however, should be able to describe and simulate the complexity of a biological system in many of its aspects. Moreover, it should be implemented by efficient algorithms requiring the shortest possible execution time, to avoid enlarging excessively the time elapsing between data analysis and any subsequent experiment. Besides the features of their topological structure, the complexity of biological networks also refers to their dynamics, that is often non-linear and stiff. The stiffness is due to the presence of molecular species whose abundance fluctuates by many orders of magnitude. A fully stochastic simulation of a stiff system is computationally time-expensive. On the other hand, continuous models are less costly, but they fail to capture the stochastic behaviour of small populations of molecular species. We introduce a new efficient hybrid stochastic-deterministic computational model and the software tool MoBioS (MOlecular Biology Simulator) implementing it. The mathematical model of MoBioS uses continuous differential equations to describe the deterministic reactions and a Gillespie-like algorithm to describe the stochastic ones. Unlike the majority of current hybrid methods, the MoBioS algorithm divides the reactions' set into fast reactions, moderate reactions, and slow reactions and implements a hysteresis switching between the stochastic model and the deterministic model. Fast reactions are approximated as continuous-deterministic processes and modelled by deterministic rate equations. Moderate reactions are those whose reaction waiting time is

  14. Educational Interpretations of General Systems Theory.

    Science.gov (United States)

    Hug, William E.; King, James E.

    This chapter discusses General Systems Theory as it applies to education, classrooms, innovations, and instructional design. The principles of equifinality, open and closed systems, the individual as the key system, hierarchical structures, optimization, stability, cooperation, and competition are discussed, and their relationship to instructional…

  15. Dynamic analysis of biochemical network using complex network method

    Directory of Open Access Journals (Sweden)

    Wang Shuqiang

    2015-01-01

    Full Text Available In this study, the stochastic biochemical reaction model is proposed based on the law of mass action and complex network theory. The dynamics of biochemical reaction system is presented as a set of non-linear differential equations and analyzed at the molecular-scale. Given the initial state and the evolution rules of the biochemical reaction system, the system can achieve homeostasis. Compared with random graph, the biochemical reaction network has larger information capacity and is more efficient in information transmission. This is consistent with theory of evolution.

  16. Get with the System: General Systems Theory for Business Officials.

    Science.gov (United States)

    Graczyk, Sandra L.

    1993-01-01

    An introduction to general systems theory and an overview of vocabulary and concepts are presented to introduce school business officials to systems thinking and to foster its use as an analytical tool. The theory is then used to analyze a sample problem: planning changes to a district's administrative computer system. (eight references) (MLF)

  17. General systems theory mathematical foundations

    CERN Document Server

    Mesarovic, Mihajlo D

    1975-01-01

    In this book, we study theoretical and practical aspects of computing methods for mathematical modelling of nonlinear systems. A number of computing techniques are considered, such as methods of operator approximation with any given accuracy; operator interpolation techniques including a non-Lagrange interpolation; methods of system representation subject to constraints associated with concepts of causality, memory and stationarity; methods of system representation with an accuracy that is the best within a given class of models; methods of covariance matrix estimation;methods for low-rank mat

  18. Distributed computer systems theory and practice

    CERN Document Server

    Zedan, H S M

    2014-01-01

    Distributed Computer Systems: Theory and Practice is a collection of papers dealing with the design and implementation of operating systems, including distributed systems, such as the amoeba system, argus, Andrew, and grapevine. One paper discusses the concepts and notations for concurrent programming, particularly language notation used in computer programming, synchronization methods, and also compares three classes of languages. Another paper explains load balancing or load redistribution to improve system performance, namely, static balancing and adaptive load balancing. For program effici

  19. The Theory of Random Laser Systems

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Xunya [Iowa State Univ., Ames, IA (United States)

    2001-01-01

    Studies of random laser systems are a new direction with promising potential applications and theoretical interest. The research is based on the theories of localization and laser physics. So far, the research shows that there are random lasing modes inside the systems which is quite different from the common laser systems. From the properties of the random lasing modes, they can understand the phenomena observed in the experiments, such as multi-peak and anisotropic spectrum, lasing mode number saturation, mode competition and dynamic processes, etc. To summarize, this dissertation has contributed the following in the study of random laser systems: (1) by comparing the Lamb theory with the Letokhov theory, the general formulas of the threshold length or gain of random laser systems were obtained; (2) they pointed out the vital weakness of previous time-independent methods in random laser research; (3) a new model which includes the FDTD method and the semi-classical laser theory. The solutions of this model provided an explanation of the experimental results of multi-peak and anisotropic emission spectra, predicted the saturation of lasing modes number and the length of localized lasing modes; (4) theoretical (Lamb theory) and numerical (FDTD and transfer-matrix calculation) studies of the origin of localized lasing modes in the random laser systems; and (5) proposal of using random lasing modes as a new path to study wave localization in random systems and prediction of the lasing threshold discontinuity at mobility edge.

  20. The Theory of Random Laser Systems

    International Nuclear Information System (INIS)

    Xunya Jiang

    2002-01-01

    Studies of random laser systems are a new direction with promising potential applications and theoretical interest. The research is based on the theories of localization and laser physics. So far, the research shows that there are random lasing modes inside the systems which is quite different from the common laser systems. From the properties of the random lasing modes, they can understand the phenomena observed in the experiments, such as multi-peak and anisotropic spectrum, lasing mode number saturation, mode competition and dynamic processes, etc. To summarize, this dissertation has contributed the following in the study of random laser systems: (1) by comparing the Lamb theory with the Letokhov theory, the general formulas of the threshold length or gain of random laser systems were obtained; (2) they pointed out the vital weakness of previous time-independent methods in random laser research; (3) a new model which includes the FDTD method and the semi-classical laser theory. The solutions of this model provided an explanation of the experimental results of multi-peak and anisotropic emission spectra, predicted the saturation of lasing modes number and the length of localized lasing modes; (4) theoretical (Lamb theory) and numerical (FDTD and transfer-matrix calculation) studies of the origin of localized lasing modes in the random laser systems; and (5) proposal of using random lasing modes as a new path to study wave localization in random systems and prediction of the lasing threshold discontinuity at mobility edge

  1. A novel classification system for aging theories

    Directory of Open Access Journals (Sweden)

    Lucas Siqueira Trindade

    2013-03-01

    Full Text Available Theories of lifespan evolution are a source of confusion amongst aging researchers. After a century of aging research the dispute over whether the aging process is active or passive persists and a comprehensive and universally accepted theoretical model remains elusive. Evolutionary aging theories primarily dispute whether the aging process is exclusively adapted to favor the kin or exclusively non-adapted to favor the individual. Interestingly, contradictory data and theories supporting both exclusively programmed and exclusively non-programmed theories continue to grow. However, this is a false dichotomy; natural selection favors traits resulting in efficient reproduction whether they benefit the individual or the kin. Thus, to understand the evolution of aging, first we must understand the environment-dependent balance between the advantages and disadvantages of extended lifespan in the process of spreading genes. As described by distinct theories, different niches and environmental conditions confer on extended lifespan a range of fitness values varying from highly beneficial to highly detrimental. Here, we considered the range of fitness values for extended lifespan and develop a fitness-based framework for categorizing existing theories. We show that all theories can be classified into four basic types: secondary (beneficial, maladaptive (neutral, assisted death (detrimental and senemorphic aging (varying between beneficial to detrimental. We anticipate that this classification system will assist with understanding and interpreting aging/death by providing a way of considering theories as members of one of these classes rather than consideration of their individual details.

  2. Acoustic array systems theory, implementation, and application

    CERN Document Server

    Bai, Mingsian R; Benesty, Jacob

    2013-01-01

    Presents a unified framework of far-field and near-field array techniques for noise source identification and sound field visualization, from theory to application. Acoustic Array Systems: Theory, Implementation, and Application provides an overview of microphone array technology with applications in noise source identification and sound field visualization. In the comprehensive treatment of microphone arrays, the topics covered include an introduction to the theory, far-field and near-field array signal processing algorithms, practical implementations, and common applic

  3. Anomalous gauge theories as constrained Hamiltonian systems

    International Nuclear Information System (INIS)

    Fujiwara, T.

    1989-01-01

    Anomalous gauge theories considered as constrained systems are investigated. The effects of chiral anomaly on the canonical structure are examined first for nonlinear σ-model and later for fermionic theory. The breakdown of the Gauss law constraints and the anomalous commutators among them are studied in a systematic way. An intrinsic mass term for gauge fields makes it possible to solve the Gauss law relations as second class constraints. Dirac brackets between the time components of gauge fields are shown to involve anomalous terms. Based upon the Ward-Takahashi identities for gauge symmetry, we investigate anomalous fermionic theory within the framework of path integral approach. (orig.)

  4. Optimization theory for large systems

    CERN Document Server

    Lasdon, Leon S

    2002-01-01

    Important text examines most significant algorithms for optimizing large systems and clarifying relations between optimization procedures. Much data appear as charts and graphs and will be highly valuable to readers in selecting a method and estimating computer time and cost in problem-solving. Initial chapter on linear and nonlinear programming presents all necessary background for subjects covered in rest of book. Second chapter illustrates how large-scale mathematical programs arise from real-world problems. Appendixes. List of Symbols.

  5. Telecommunications system reliability engineering theory and practice

    CERN Document Server

    Ayers, Mark L

    2012-01-01

    "Increasing system complexity require new, more sophisticated tools for system modeling and metric calculation. Bringing the field up to date, this book provides telecommunications engineers with practical tools for analyzing, calculating, and reporting availability, reliability, and maintainability metrics. It gives the background in system reliability theory and covers in-depth applications in fiber optic networks, microwave networks, satellite networks, power systems, and facilities management. Computer programming tools for simulating the approaches presented, using the Matlab software suite, are also provided"

  6. Dynamic Systems Theory and Team Sport Coaching

    Science.gov (United States)

    Gréhaigne, Jean-Francis; Godbout, Paul

    2014-01-01

    This article examines the theory of dynamic systems and its use in the domains of the study and coaching of team sports. The two teams involved in a match are looked at as two interacting systems in movement, where opposition is paramount. A key element for the observation of game play is the notion of configuration of play and its ever-changing…

  7. Correlation control theory of chaotic laser systems

    International Nuclear Information System (INIS)

    Li Fuli.

    1986-04-01

    A novel control theory of chaotic systems is studied. The correlation functions are calculated and used as feedback signals of the chaotic lasers. Computer experiments have shown that in this way the chaotic systems can be controlled to have time-independent output when the external control parameters are in chaotic domain. (author)

  8. Rube Goldberg Salad System: Teaching Systems Theory in Communication

    Science.gov (United States)

    Linabary, Jasmine R.; Long, Ziyu; Mouton, Ashton; Rao, Ranjani L.; Buzzanell, Patrice M.

    2016-01-01

    Systems theory has been a staple in organizational communication textbooks since the field's inception (Miller, 2015; Poole, 2014). Nevertheless, the authors' classroom experiences have revealed that systems theory may not seem applicable to students due to its complicated nature. While examples and cases can help students make sense of the…

  9. Sampling systems theory and its application

    CERN Document Server

    Tsypkin, Ya Z; Higinbotham, W

    1964-01-01

    Sampling Systems Theory and its Application, Volume 2 is a two-chapter text that focuses on closed pulse systems.The first chapter highlights the fundamentals of closed pulse systems. This chapter particularly tackles the equations, transfer functions, stability, frequency, characteristics, processes, and synthesis of these systems. The second chapter discusses the automatic temperature, ranging, and frequency control system and non-contact servo-system of closed pulse systems. This chapter also looks into the smoothing and prediction of discrete data in digital computers.This book will prove

  10. Dynamical Systems Theory: Application to Pedagogy

    Science.gov (United States)

    Abraham, Jane L.

    Theories of learning affect how cognition is viewed, and this subsequently leads to the style of pedagogical practice that is used in education. Traditionally, educators have relied on a variety of theories on which to base pedagogy. Behavioral learning theories influenced the teaching/learning process for over 50 years. In the 1960s, the information processing approach brought the mind back into the learning process. The current emphasis on constructivism integrates the views of Piaget, Vygotsky, and cognitive psychology. Additionally, recent scientific advances have allowed researchers to shift attention to biological processes in cognition. The problem is that these theories do not provide an integrated approach to understanding principles responsible for differences among students in cognitive development and learning ability. Dynamical systems theory offers a unifying theoretical framework to explain the wider context in which learning takes place and the processes involved in individual learning. This paper describes how principles of Dynamic Systems Theory can be applied to cognitive processes of students, the classroom community, motivation to learn, and the teaching/learning dynamic giving educational psychologists a framework for research and pedagogy.

  11. ENVIRONMENTAL SYSTEMS MANAGEMENT AND SUSTAINABLE SYSTEMS THEORY

    Science.gov (United States)

    Environmental Systems Management is the management of environmental problems at the systems level fully accounting for the multi-dimensional nature of the environment. This includes socio-economic dimensions as well as the usual physical and life science aspects. This is importa...

  12. Topological theory of dynamical systems recent advances

    CERN Document Server

    Aoki, N

    1994-01-01

    This monograph aims to provide an advanced account of some aspects of dynamical systems in the framework of general topology, and is intended for use by interested graduate students and working mathematicians. Although some of the topics discussed are relatively new, others are not: this book is not a collection of research papers, but a textbook to present recent developments of the theory that could be the foundations for future developments. This book contains a new theory developed by the authors to deal with problems occurring in diffentiable dynamics that are within the scope of general topology. To follow it, the book provides an adequate foundation for topological theory of dynamical systems, and contains tools which are sufficiently powerful throughout the book. Graduate students (and some undergraduates) with sufficient knowledge of basic general topology, basic topological dynamics, and basic algebraic topology will find little difficulty in reading this book.

  13. Inference of Biochemical S-Systems via Mixed-Variable Multiobjective Evolutionary Optimization

    Directory of Open Access Journals (Sweden)

    Yu Chen

    2017-01-01

    Full Text Available Inference of the biochemical systems (BSs via experimental data is important for understanding how biochemical components in vivo interact with each other. However, it is not a trivial task because BSs usually function with complex and nonlinear dynamics. As a popular ordinary equation (ODE model, the S-System describes the dynamical properties of BSs by incorporating the power rule of biochemical reactions but behaves as a challenge because it has a lot of parameters to be confirmed. This work is dedicated to proposing a general method for inference of S-Systems by experimental data, using a biobjective optimization (BOO model and a specially mixed-variable multiobjective evolutionary algorithm (mv-MOEA. Regarding that BSs are sparse in common sense, we introduce binary variables indicating network connections to eliminate the difficulty of threshold presetting and take data fitting error and the L0-norm as two objectives to be minimized in the BOO model. Then, a selection procedure that automatically runs tradeoff between two objectives is employed to choose final inference results from the obtained nondominated solutions of the mv-MOEA. Inference results of the investigated networks demonstrate that our method can identify their dynamical properties well, although the automatic selection procedure sometimes ignores some weak connections in BSs.

  14. A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems

    Directory of Open Access Journals (Sweden)

    Goutsias John

    2010-05-01

    Full Text Available Abstract Background Sensitivity analysis is an indispensable tool for the analysis of complex systems. In a recent paper, we have introduced a thermodynamically consistent variance-based sensitivity analysis approach for studying the robustness and fragility properties of biochemical reaction systems under uncertainty in the standard chemical potentials of the activated complexes of the reactions and the standard chemical potentials of the molecular species. In that approach, key sensitivity indices were estimated by Monte Carlo sampling, which is computationally very demanding and impractical for large biochemical reaction systems. Computationally efficient algorithms are needed to make variance-based sensitivity analysis applicable to realistic cellular networks, modeled by biochemical reaction systems that consist of a large number of reactions and molecular species. Results We present four techniques, derivative approximation (DA, polynomial approximation (PA, Gauss-Hermite integration (GHI, and orthonormal Hermite approximation (OHA, for analytically approximating the variance-based sensitivity indices associated with a biochemical reaction system. By using a well-known model of the mitogen-activated protein kinase signaling cascade as a case study, we numerically compare the approximation quality of these techniques against traditional Monte Carlo sampling. Our results indicate that, although DA is computationally the most attractive technique, special care should be exercised when using it for sensitivity analysis, since it may only be accurate at low levels of uncertainty. On the other hand, PA, GHI, and OHA are computationally more demanding than DA but can work well at high levels of uncertainty. GHI results in a slightly better accuracy than PA, but it is more difficult to implement. OHA produces the most accurate approximation results and can be implemented in a straightforward manner. It turns out that the computational cost of the

  15. Intersubjective systems theory: a fallibilist's journey.

    Science.gov (United States)

    Orange, Donna M

    2009-04-01

    Intersubjective systems theory is the view that personal experience always emerges, maintains itself, and transforms in relational contexts. It is held for reasons of personal inclinations, philosophical belief, and clinical conviction. As a clinical sensibility, it primarily includes an emphasis on the emotional convictions or organizing principles that systematize experience, the personal engagement of the analyst, and the refusal to argue about reality.

  16. Pathways, Networks, and Systems: Theory and Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Joseph H. Nadeau; John D. Lambris

    2004-10-30

    The international conference provided a unique opportunity for theoreticians and experimenters to exchange ideas, strategies, problems, challenges, language and opportunities in both formal and informal settings. This dialog is an important step towards developing a deep and effective integration of theory and experiments in studies of systems biology in humans and model organisms.

  17. General Systems Theory and Counterplan Competition.

    Science.gov (United States)

    Madsen, Arnie

    1989-01-01

    Discusses the trend in academic debate on policy questions toward a wide acceptance of counterplans, encouraging combinations of proposals which appear at face value able to coexist but upon deeper analysis are incompatible. Argues in opposition to this trend by applying concepts from general systems theory to competition. (KEH)

  18. Possibilistic systems within a general information theory

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, C.

    1999-06-01

    The author surveys possibilistic systems theory and place it in the context of Imprecise Probabilities and General Information Theory (GIT). In particular, he argues that possibilistic systems hold a distinct position within a broadly conceived, synthetic GIT. The focus is on systems and applications which are semantically grounded by empirical measurement methods (statistical counting), rather than epistemic or subjective knowledge elicitation or assessment methods. Regarding fuzzy measures as special provisions, and evidence measures (belief and plausibility measures) as special fuzzy measures, thereby he can measure imprecise probabilities directly and empirically from set-valued frequencies (random set measurement). More specifically, measurements of random intervals yield empirical fuzzy intervals. In the random set (Dempster-Shafer) context, probability and possibility measures stand as special plausibility measures in that their distributionality (decomposability) maps directly to an aggregable structure of the focal classes of their random sets. Further, possibility measures share with imprecise probabilities the ability to better handle open world problems where the universe of discourse is not specified in advance. In addition to empirically grounded measurement methods, possibility theory also provides another crucial component of a full systems theory, namely prediction methods in the form of finite (Markov) processes which are also strictly analogous to the probabilistic forms.

  19. Ecological Systems Theory in "School Psychology Review"

    Science.gov (United States)

    Burns, Matthew K.; Warmbold-Brann, Kristy; Zaslofsky, Anne F.

    2015-01-01

    Ecological systems theory (EST) has been suggested as a framework to provide effective school psychology services, but previous reviews of research found questionable consistency between methods and the principles of EST. The current article reviewed 349 articles published in "School Psychology Review" (SPR) between 2006 and 2015 and…

  20. Theory and Simulation of Multicomponent Osmotic Systems.

    Science.gov (United States)

    Karunaweera, Sadish; Gee, Moon Bae; Weerasinghe, Samantha; Smith, Paul E

    2012-05-28

    Most cellular processes occur in systems containing a variety of components many of which are open to material exchange. However, computer simulations of biological systems are almost exclusively performed in systems closed to material exchange. In principle, the behavior of biomolecules in open and closed systems will be different. Here, we provide a rigorous framework for the analysis of experimental and simulation data concerning open and closed multicomponent systems using the Kirkwood-Buff (KB) theory of solutions. The results are illustrated using computer simulations for various concentrations of the solutes Gly, Gly(2) and Gly(3) in both open and closed systems, and in the absence or presence of NaCl as a cosolvent. In addition, KB theory is used to help rationalize the aggregation properties of the solutes. Here one observes that the picture of solute association described by the KB integrals, which are directly related to the solution thermodynamics, and that provided by more physical clustering approaches are different. It is argued that the combination of KB theory and simulation data provides a simple and powerful tool for the analysis of complex multicomponent open and closed systems.

  1. A theory of desynchronisable closed loop system

    Directory of Open Access Journals (Sweden)

    Harsh Beohar

    2010-10-01

    Full Text Available The task of implementing a supervisory controller is non-trivial, even though different theories exist that allow automatic synthesis of these controllers in the form of automata. One of the reasons for this discord is due to the asynchronous interaction between a plant and its controller in implementations, whereas the existing supervisory control theories assume synchronous interaction. As a consequence the implementation suffer from the so-called inexact synchronisation problem. In this paper we address the issue of inexact synchronisation in a process algebraic setting, by solving a more general problem of refinement. We construct an asynchronous closed loop system by introducing a communication medium in a given synchronous closed loop system. Our goal is to find sufficient conditions under which a synchronous closed loop system is branching bisimilar to its corresponding asynchronous closed loop system.

  2. Propositional systems in local field theories

    International Nuclear Information System (INIS)

    Banai, M.

    1980-07-01

    The authors investigate propositional systems for local field theories, which reflect intrinsically the uncertainties of measurements made on the physical system, and satisfy the isotony and local commutativity postulates of Haag and Kastler. The spacetime covariance can be implemented in natural way in these propositional systems. New techniques are introduced to obtain these propositional systems: the lattice-valued logics. The decomposition of the complete orthomodular lattice-valued logics shows that these logics are more general than the usual two-valued ones and that in these logics there is enough structure to characterize the classical and quantum, non relativistic and relativistic local field theories in a natural way. The Hilbert modules give the natural inner product ''spaces'' (modules) for the realization of the lattice-valued logics. (author)

  3. Propositional systems in local field theories

    Energy Technology Data Exchange (ETDEWEB)

    Banai, M.

    1981-03-01

    We investigate propositional systems for local field theories, which reflect intrinsically the uncertainties of measurements made on the physical system, and satisfy the isotony and local commutativity postulates of Haag and Kastler. The space-time covariance can be implemented in a natural way in these propositional systems. New techniques are introduced to obtain these propositional systems: the lattice-valued logics. The decomposition of the complete orthomodular lattice-valued logics shows that these logics are more general than the usual two-valued ones and that in these there is enough structure to characterize the classical and quantum, nonrelativistic and relativistic local field theories in a natural way. The Hilbert modules give the natural inner product ''spaces'' (modules) for the realization of the lattice-valued logics.

  4. Meta-stochastic simulation of biochemical models for systems and synthetic biology.

    Science.gov (United States)

    Sanassy, Daven; Widera, Paweł; Krasnogor, Natalio

    2015-01-16

    Stochastic simulation algorithms (SSAs) are used to trace realistic trajectories of biochemical systems at low species concentrations. As the complexity of modeled biosystems increases, it is important to select the best performing SSA. Numerous improvements to SSAs have been introduced but they each only tend to apply to a certain class of models. This makes it difficult for a systems or synthetic biologist to decide which algorithm to employ when confronted with a new model that requires simulation. In this paper, we demonstrate that it is possible to determine which algorithm is best suited to simulate a particular model and that this can be predicted a priori to algorithm execution. We present a Web based tool ssapredict that allows scientists to upload a biochemical model and obtain a prediction of the best performing SSA. Furthermore, ssapredict gives the user the option to download our high performance simulator ngss preconfigured to perform the simulation of the queried biochemical model with the predicted fastest algorithm as the simulation engine. The ssapredict Web application is available at http://ssapredict.ico2s.org. It is free software and its source code is distributed under the terms of the GNU Affero General Public License.

  5. Solar-System Tests of Gravitational Theories

    Science.gov (United States)

    Shapiro, Irwin I.

    2002-01-01

    We are engaged in testing gravitational theory by means of observations of objects in the solar system. This work tests the equivalence principle (EP), the Shapiro time delay, the advances of planetary perihelion, the possibility of a secular variation G(dot) in the 'gravitational constant' G, and the rate of the de Sitter (geodetic) precession of the Earth-Moon system. We describe here the results under this contract.

  6. Geometric theory of discrete nonautonomous dynamical systems

    CERN Document Server

    Pötzsche, Christian

    2010-01-01

    Nonautonomous dynamical systems provide a mathematical framework for temporally changing phenomena, where the law of evolution varies in time due to seasonal, modulation, controlling or even random effects. Our goal is to provide an approach to the corresponding geometric theory of nonautonomous discrete dynamical systems in infinite-dimensional spaces by virtue of 2-parameter semigroups (processes). These dynamical systems are generated by implicit difference equations, which explicitly depend on time. Compactness and dissipativity conditions are provided for such problems in order to have attractors using the natural concept of pullback convergence. Concerning a necessary linear theory, our hyperbolicity concept is based on exponential dichotomies and splittings. This concept is in turn used to construct nonautonomous invariant manifolds, so-called fiber bundles, and deduce linearization theorems. The results are illustrated using temporal and full discretizations of evolutionary differential equations.

  7. Specification, construction, and exact reduction of state transition system models of biochemical processes.

    Science.gov (United States)

    Bugenhagen, Scott M; Beard, Daniel A

    2012-10-21

    Biochemical reaction systems may be viewed as discrete event processes characterized by a number of states and state transitions. These systems may be modeled as state transition systems with transitions representing individual reaction events. Since they often involve a large number of interactions, it can be difficult to construct such a model for a system, and since the resulting state-level model can involve a huge number of states, model analysis can be difficult or impossible. Here, we describe methods for the high-level specification of a system using hypergraphs, for the automated generation of a state-level model from a high-level model, and for the exact reduction of a state-level model using information from the high-level model. Exact reduction is achieved through the automated application to the high-level model of the symmetry reduction technique and reduction by decomposition by independent subsystems, allowing potentially significant reductions without the need to generate a full model. The application of the method to biochemical reaction systems is illustrated by models describing a hypothetical ion-channel at several levels of complexity. The method allows for the reduction of the otherwise intractable example models to a manageable size.

  8. Synthesizing Configurable Biochemical Implementation of Linear Systems from Their Transfer Function Specifications.

    Directory of Open Access Journals (Sweden)

    Tai-Yin Chiu

    Full Text Available The ability to engineer synthetic systems in the biochemical context is constantly being improved and has a profound societal impact. Linear system design is one of the most pervasive methods applied in control tasks, and its biochemical realization has been proposed by Oishi and Klavins and advanced further in recent years. However, several technical issues remain unsolved. Specifically, the design process is not fully automated from specification at the transfer function level, systems once designed often lack dynamic adaptivity to environmental changes, matching rate constants of reactions is not always possible, and implementation may be approximative and greatly deviate from the specifications. Building upon the work of Oishi and Klavins, this paper overcomes these issues by introducing a design flow that transforms a transfer-function specification of a linear system into a set of chemical reactions, whose input-output response precisely conforms to the specification. This system is implementable using the DNA strand displacement technique. The underlying configurability is embedded into primitive components and template modules, and thus the entire system is adaptive. Simulation of DNA strand displacement implementation confirmed the feasibility and superiority of the proposed synthesis flow.

  9. Symmetric linear systems - An application of algebraic systems theory

    Science.gov (United States)

    Hazewinkel, M.; Martin, C.

    1983-01-01

    Dynamical systems which contain several identical subsystems occur in a variety of applications ranging from command and control systems and discretization of partial differential equations, to the stability augmentation of pairs of helicopters lifting a large mass. Linear models for such systems display certain obvious symmetries. In this paper, we discuss how these symmetries can be incorporated into a mathematical model that utilizes the modern theory of algebraic systems. Such systems are inherently related to the representation theory of algebras over fields. We will show that any control scheme which respects the dynamical structure either implicitly or explicitly uses the underlying algebra.

  10. Efficient simulation of intrinsic, extrinsic and external noise in biochemical systems.

    Science.gov (United States)

    Pischel, Dennis; Sundmacher, Kai; Flassig, Robert J

    2017-07-15

    Biological cells operate in a noisy regime influenced by intrinsic, extrinsic and external noise, which leads to large differences of individual cell states. Stochastic effects must be taken into account to characterize biochemical kinetics accurately. Since the exact solution of the chemical master equation, which governs the underlying stochastic process, cannot be derived for most biochemical systems, approximate methods are used to obtain a solution. In this study, a method to efficiently simulate the various sources of noise simultaneously is proposed and benchmarked on several examples. The method relies on the combination of the sigma point approach to describe extrinsic and external variability and the τ -leaping algorithm to account for the stochasticity due to probabilistic reactions. The comparison of our method to extensive Monte Carlo calculations demonstrates an immense computational advantage while losing an acceptable amount of accuracy. Additionally, the application to parameter optimization problems in stochastic biochemical reaction networks is shown, which is rarely applied due to its huge computational burden. To give further insight, a MATLAB script is provided including the proposed method applied to a simple toy example of gene expression. MATLAB code is available at Bioinformatics online. flassig@mpi-magdeburg.mpg.de. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  11. Robust control systems theory and case studies

    CERN Document Server

    Mackenroth, Uwe

    2004-01-01

    "Robust Control Systems" gives a self-contained introduction to modern Control Theory. It thus adds a textbook to the existing research-oriented literature on Robust Control. The author lays emphasis on the modern aspects of the design of controllers with prescribed performance and robustness properties. Different to the classical engineering approach, a rigorous mathematical treatment is essential for the full understanding and applicability of the modern methods such as H2 or H8 control or methods based on the structured singular value µ. Nevertheless, no prior knowledge of Control Theory is required as the classical fundamentals are introduced within the first few chapters. Subsequently a large part of the text provides elementary examples and industrial case studies, which are developed in full detail to show how modern methods can be applied to advanced problems. They make intensive use of MATLAB, especially the Control Systems Toolbox and the µ-Analysis and Synthesis Toolbox.

  12. Theory and design of CNC systems

    CERN Document Server

    Suh, Suk-Hwan; Chung, Dae-Hyuk; Stroud, Ian

    2008-01-01

    Computer Numerical Control (CNC) controllers are high value-added products counting for over 30% of the price of machine tools. The development of CNC technology depends on the integration of technologies from many different industries, and requires strategic long-term support. a oeTheory and Design of CNC Systemsa covers the elements of control, the design of control systems, and modern open-architecture control systems. Topics covered include Numerical Control Kernel (NCK) design of CNC, Programmable Logic Control (PLC), and the Man-Machine Interface (MMI), as well as the major modules for t

  13. IDEA: A Unifying Theory for Evaluation Systems

    DEFF Research Database (Denmark)

    Bella, Giampaolo; Giustolisi, Rosario

    2017-01-01

    and the type of evaluation. The uniformity of the security requirements across all groups offers additional validation, and this is an innovative finding in the direction, currently unexplored, of a common system design. Still, the requirements may variously shape up. For example, while voter privacy......Secure systems for voting, exams, auctions and conference paper management are theorised to address the same problem, that of secure evaluations. In support of such a unifying theory comes a model for Secure Evaluation Systems (SES), which offers innovative common grounds to understand all four...... groups. For example, all rest on submissions, respectively votes, test answers, bids and papers, which are to be evaluated and ultimately ranked. A taxonomy for all groups is advanced to provide a comparative understanding of the various systems. The taxonomy is built according to the type of submissions...

  14. Scattering theory for open quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Behrndt, Jussi [Technische Univ. Berlin (Germany). Inst. fuer Mathematik; Malamud, Mark M. [Donetsk National University (Ukraine). Dept. of Mathematics; Neidhardt, Hagen [Weierstrass-Institut fuer Angewandte Analysis und Stochastik (WIAS) im Forschungsverbund Berlin e.V. (Germany)

    2006-07-01

    Quantum systems which interact with their environment are often modeled by maximal dissipative operators or so-called Pseudo-Hamiltonians. In this paper the scattering theory for such open systems is considered. First it is assumed that a single maximal dissipative operator A{sub D} in a Hilbert space H is used to describe an open quantum system. In this case the minimal self-adjoint dilation K of A{sub D} can be regarded as the Hamiltonian of a closed system which contains the open system {l_brace}A{sub D},h{r_brace}, but since K is necessarily not semibounded from below, this model is difficult to interpret from a physical point of view. In the second part of the paper an open quantum system is modeled with a family {l_brace}A({mu}){r_brace} of maximal dissipative operators depending on energy {mu}, and it is shown that the open system can be embedded into a closed system where the Hamiltonian is semibounded. Surprisingly it turns out that the corresponding scattering matrix can be completely recovered from scattering matrices of single Pseudo-Hamiltonians as in the first part of the paper. The general results are applied to a class of Sturm-Liouville operators arising in dissipative and quantum transmitting Schroedinger-Poisson systems. (orig.)

  15. Influence of Fasciola Hepatica on Serum Biochemical Parameters and Vascular and Biliary System of Sheep Liver

    Directory of Open Access Journals (Sweden)

    A Hodžić

    2013-03-01

    Full Text Available Background: The aim of this study was to evaluate the functional capacity of the liver based on the activity of specific enzymes and bilirubin in serum and also to investigate the influence of mechanical and toxic effects of Fasciola hepatica on the structures of the blood vessels and biliary tract in the sheep liver.Methods: Blood samples and liver of 63 indigenous sheep of Pramenka breed, slaughtered in the period from March to December 2009 were used. Based on parasitological findings in the liver, all animals were divided into two groups: control (n=34 and infected group (n=29. For investigation and description of pathological changes in sheep liver, naturally infected with F. hepatica, corrosion cast technique was used.Results: Biochemical analysis of tested parameters showed a significant elevation (P≤0.05 of serum gamma-glutamyl transferase (GGT, total bilirubin (TBIL and direct bilirubin (DBIL in infected sheep group comparing with the control group. No significant differences were observed for activity of aspartate aminotranferase (AST between groups. Vascular and biliary systems of the liver were found to be affected.Conclusion: Results of biochemical analysis are consistent with pathological findings and measuring of tested parameters could be used in early diagnosis of sheep fasciolosis and to test the effectiveness of anthelmintic therapy. Corrosion cast technique is very useful for investigation of pathological changes and neoangiogenesis of vascular and biliary system in sheep liver, caused by mechanical and toxic effects of F. hepatica.

  16. Influence of Fasciola hepatica on Serum Biochemical Parameters and Vascular and Biliary System of Sheep Liver

    Science.gov (United States)

    Hodžić, A; Zuko, A; Avdić, R; Alić, A; Omeragić, J; Jažić, A

    2013-01-01

    Background The aim of this study was to evaluate the functional capacity of the liver based on the activity of specific enzymes and bilirubin in serum and also to investigate the influence of mechanical and toxic effects of Fasciola hepatica on the structures of the blood vessels and biliary tract in the sheep liver. Methods Blood samples and liver of 63 indigenous sheep of Pramenka breed, slaughtered in the period from March to December 2009 were used. Based on parasitological findings in the liver, all animals were divided into two groups: control (n = 34) and infected group (n = 29). For investigation and description of pathological changes in sheep liver, naturally infected with F. hepatica, corrosion cast technique was used. Results Biochemical analysis of tested parameters showed a significant elevation (P≤0.05) of serum gamma-glutamyl transferase (GGT), total bilirubin (TBIL) and direct bilirubin (DBIL) in infected sheep group comparing with the control group. No significant differences were observed for activity of aspartate aminotranferase (AST) between groups. Vascular and biliary systems of the liver were found to be affected. Conclusion Results of biochemical analysis are consistent with pathological findings and measuring of tested parameters could be used in early diagnosis of sheep fasciolosis and to test the effectiveness of anthelmintic therapy. Corrosion cast technique is very useful for investigation of pathological changes and neoangiogenesis of vascular and biliary system in sheep liver, caused by mechanical and toxic effects of F. hepatica. PMID:23682266

  17. Applied optimal control theory of distributed systems

    CERN Document Server

    Lurie, K A

    1993-01-01

    This book represents an extended and substantially revised version of my earlierbook, Optimal Control in Problems ofMathematical Physics,originally published in Russian in 1975. About 60% of the text has been completely revised and major additions have been included which have produced a practically new text. My aim was to modernize the presentation but also to preserve the original results, some of which are little known to a Western reader. The idea of composites, which is the core of the modern theory of optimization, was initiated in the early seventies. The reader will find here its implementation in the problem of optimal conductivity distribution in an MHD-generatorchannel flow.Sincethen it has emergedinto an extensive theory which is undergoing a continuous development. The book does not pretend to be a textbook, neither does it offer a systematic presentation of the theory. Rather, it reflects a concept which I consider as fundamental in the modern approach to optimization of dis­ tributed systems. ...

  18. Rate-independent systems theory and application

    CERN Document Server

    Mielke, Alexander

    2015-01-01

    This monograph provides both an introduction to and a thorough exposition of the theory of rate-independent systems, which the authors have worked on with a number of collaborators over many years. The focus is mostly on fully rate-independent systems, first on an abstract level with or without a linear structure, discussing various concepts of solutions with full mathematical rigor. The usefulness of the abstract concepts is then demonstrated on the level of various applications primarily in continuum mechanics of solids, including suitable approximation strategies with guaranteed numerical stability and convergence. Particular applications concern inelastic processes such as plasticity, damage, phase transformations, or adhesive-type contacts both at small strains and at finite strains. Other physical systems such as magnetic or ferroelectric materials, and couplings to rate-dependent thermodynamic models are also considered. Selected applications are accompanied by numerical simulations illustrating both t...

  19. Systems biology: the reincarnation of systems theory applied in biology?

    Science.gov (United States)

    Wolkenhauer, O

    2001-09-01

    With the availability of quantitative data on the transcriptome and proteome level, there is an increasing interest in formal mathematical models of gene expression and regulation. International conferences, research institutes and research groups concerned with systems biology have appeared in recent years and systems theory, the study of organisation and behaviour per se, is indeed a natural conceptual framework for such a task. This is, however, not the first time that systems theory has been applied in modelling cellular processes. Notably in the 1960s systems theory and biology enjoyed considerable interest among eminent scientists, mathematicians and engineers. Why did these early attempts vanish from research agendas? Here we shall review the domain of systems theory, its application to biology and the lessons that can be learned from the work of Robert Rosen. Rosen emerged from the early developments in the 1960s as a main critic but also developed a new alternative perspective to living systems, a concept that deserves a fresh look in the post-genome era of bioinformatics.

  20. Inelastic transport theory for nanoscale systems

    DEFF Research Database (Denmark)

    Frederiksen, Thomas

    2007-01-01

    This thesis describes theoretical and numerical investigations of inelastic scat- tering and energy dissipation in electron transport through nanoscale sys- tems. A computational scheme, based on a combination of density functional theory (DFT) and nonequilibrium Green’s functions (NEGF), has been...... the conductance. The methods have been applied to a number of specific systems, includ- ing monatomic gold chains, atomic point contacts, and metal-molecule-metal configurations. These studies have clarified the inelastic effects in the elec- tron transport and characterized the vibrational modes that couple...

  1. Kinetic theory for strongly coupled Coulomb systems

    Science.gov (United States)

    Dufty, James; Wrighton, Jeffrey

    2018-01-01

    The calculation of dynamical properties for matter under extreme conditions is a challenging task. The popular Kubo-Greenwood model exploits elements from equilibrium density-functional theory (DFT) that allow a detailed treatment of electron correlations, but its origin is largely phenomenological; traditional kinetic theories have a more secure foundation but are limited to weak ion-electron interactions. The objective here is to show how a combination of the two evolves naturally from the short-time limit for the generator of the effective single-electron dynamics governing time correlation functions without such limitations. This provides a theoretical context for the current DFT-related approach, the Kubo-Greenwood model, while showing the nature of its corrections. The method is to calculate the short-time dynamics in the single-electron subspace for a given configuration of the ions. This differs from the usual kinetic theory approach in which an average over the ions is performed as well. In this way the effective ion-electron interaction includes strong Coulomb coupling and is shown to be determined from DFT. The correlation functions have the form of the random-phase approximation for an inhomogeneous system but with renormalized ion-electron and electron-electron potentials. The dynamic structure function, density response function, and electrical conductivity are calculated as examples. The static local field corrections in the dielectric function are identified in this way. The current analysis is limited to semiclassical electrons (quantum statistical potentials), so important quantum conditions are excluded. However, a quantization of the kinetic theory is identified for broader application while awaiting its detailed derivation.

  2. Rethinking World System Theory: A Historical and Conceptual Analysis

    OpenAIRE

    Agussalim, Burhanuddin

    2015-01-01

    - This article is a historical and conceptual analysis of World Systems Theory which proposed by Immanuel Wallerstein. This paper aims to explore historical framework of world system theory, explain the unit of analysis, and describe its relationship with other social science theories. Historical exploration of Wallerstein and this theory show a strong influence of historical study were obtained from Wallerstein background and people around him. Conceptual analysis to this theory shows tha...

  3. A review on bio-electrochemical systems (BESs) for the syngas and value added biochemicals production.

    Science.gov (United States)

    Kumar, Gopalakrishnan; Saratale, Rijuta Ganesh; Kadier, Abudukeremu; Sivagurunathan, Periyasamy; Zhen, Guangyin; Kim, Sang-Hyoun; Saratale, Ganesh Dattatraya

    2017-06-01

    Bio-electrochemical systems (BESs) are the microbial systems which are employed to produce electricity directly from organic wastes along with some valuable chemicals production such as medium chain fatty acids; acetate, butyrate and alcohols. In this review, recent updates about value-added chemicals production concomitantly with the production of gaseous fuels like hydrogen and methane which are considered as cleaner for the environment have been addressed. Additionally, the bottlenecks associated with the conversion rates, lower yields and other aspects have been mentioned. In spite of its infant stage development, this would be the future trend of energy, biochemicals and electricity production in greener and cleaner pathway with the win-win situation of organic waste remediation. Henceforth, this review intends to summarise and foster the progress made in the BESs and discusses its challenges and outlook on future research advances. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Ion-optics calculations of the LLNL AMS system for biochemical 14C measurements

    Science.gov (United States)

    Ognibene, T. J.; Brown, T. A.; Knezovich, J. P.; Roberts, M. L.; Southon, J. R.; Vogel, J. S.

    2000-10-01

    A dedicated AMS system for biochemical 14C measurements is being built at the Center for Accelerator Mass Spectrometry. The system is centered around a National Electrostatics Corporation Model 3SDH-1 1-MV Pelletron accelerator and is designed to accept two ion sources. The LLNL 64-sample Cs-sputter ion source with its zoom lens beam line is attached to one port of the electrostatic switching element. To insure efficient coupling of the source to the acceptance of the accelerator, ion-optics calculations of the low-energy injection beam line have been conducted; the results of which were used to determine the layout of the ion-optical components of the beam line. Beam tests of the low-energy injection line show that beam behavior was accurately predicted by the calculations.

  5. Theories and simulations of complex social systems

    CERN Document Server

    Mago, Vijay

    2014-01-01

    Research into social systems is challenging due to their complex nature. Traditional methods of analysis are often difficult to apply effectively as theories evolve over time. This can be due to a lack of appropriate data, or too much uncertainty. It can also be the result of problems which are not yet understood well enough in the general sense so that they can be classified, and an appropriate solution quickly identified. Simulation is one tool that deals well with these challenges, fits in well with the deductive process, and is useful for testing theory. This field is still relatively new, and much of the work is necessarily innovative, although it builds upon a rich and varied foundation. There are a number of existing modelling paradigms being applied to complex social systems research. Additionally, new methods and measures are being devised through the process of conducting research. We expect that readers will enjoy the collection of high quality research works from new and accomplished researchers. ...

  6. Theory and Simulations of Solar System Plasmas

    Science.gov (United States)

    Goldstein, Melvyn L.

    2011-01-01

    "Theory and simulations of solar system plasmas" aims to highlight results from microscopic to global scales, achieved by theoretical investigations and numerical simulations of the plasma dynamics in the solar system. The theoretical approach must allow evidencing the universality of the phenomena being considered, whatever the region is where their role is studied; at the Sun, in the solar corona, in the interplanetary space or in planetary magnetospheres. All possible theoretical issues concerning plasma dynamics are welcome, especially those using numerical models and simulations, since these tools are mandatory whenever analytical treatments fail, in particular when complex nonlinear phenomena are at work. Comparative studies for ongoing missions like Cassini, Cluster, Demeter, Stereo, Wind, SDO, Hinode, as well as those preparing future missions and proposals, like, e.g., MMS and Solar Orbiter, are especially encouraged.

  7. Selective evolutionary generation systems: Theory and applications

    Science.gov (United States)

    Menezes, Amor A.

    This dissertation is devoted to the problem of behavior design, which is a generalization of the standard global optimization problem: instead of generating the optimizer, the generalization produces, on the space of candidate optimizers, a probability density function referred to as the behavior. The generalization depends on a parameter, the level of selectivity, such that as this parameter tends to infinity, the behavior becomes a delta function at the location of the global optimizer. The motivation for this generalization is that traditional off-line global optimization is non-resilient and non-opportunistic. That is, traditional global optimization is unresponsive to perturbations of the objective function. On-line optimization methods that are more resilient and opportunistic than their off-line counterparts typically consist of the computationally expensive sequential repetition of off-line techniques. A novel approach to inexpensive resilience and opportunism is to utilize the theory of Selective Evolutionary Generation Systems (SECS), which sequentially and probabilistically selects a candidate optimizer based on the ratio of the fitness values of two candidates and the level of selectivity. Using time-homogeneous, irreducible, ergodic Markov chains to model a sequence of local, and hence inexpensive, dynamic transitions, this dissertation proves that such transitions result in behavior that is called rational; such behavior is desirable because it can lead to both efficient search for an optimizer as well as resilient and opportunistic behavior. The dissertation also identifies system-theoretic properties of the proposed scheme, including equilibria, their stability and their optimality. Moreover, this dissertation demonstrates that the canonical genetic algorithm with fitness proportional selection and the (1+1) evolutionary strategy are particular cases of the scheme. Applications in three areas illustrate the versatility of the SECS theory: flight

  8. An effective rate equation approach to reaction kinetics in small volumes: theory and application to biochemical reactions in nonequilibrium steady-state conditions.

    Science.gov (United States)

    Grima, R

    2010-07-21

    Chemical master equations provide a mathematical description of stochastic reaction kinetics in well-mixed conditions. They are a valid description over length scales that are larger than the reactive mean free path and thus describe kinetics in compartments of mesoscopic and macroscopic dimensions. The trajectories of the stochastic chemical processes described by the master equation can be ensemble-averaged to obtain the average number density of chemical species, i.e., the true concentration, at any spatial scale of interest. For macroscopic volumes, the true concentration is very well approximated by the solution of the corresponding deterministic and macroscopic rate equations, i.e., the macroscopic concentration. However, this equivalence breaks down for mesoscopic volumes. These deviations are particularly significant for open systems and cannot be calculated via the Fokker-Planck or linear-noise approximations of the master equation. We utilize the system-size expansion including terms of the order of Omega(-1/2) to derive a set of differential equations whose solution approximates the true concentration as given by the master equation. These equations are valid in any open or closed chemical reaction network and at both the mesoscopic and macroscopic scales. In the limit of large volumes, the effective mesoscopic rate equations become precisely equal to the conventional macroscopic rate equations. We compare the three formalisms of effective mesoscopic rate equations, conventional rate equations, and chemical master equations by applying them to several biochemical reaction systems (homodimeric and heterodimeric protein-protein interactions, series of sequential enzyme reactions, and positive feedback loops) in nonequilibrium steady-state conditions. In all cases, we find that the effective mesoscopic rate equations can predict very well the true concentration of a chemical species. This provides a useful method by which one can quickly determine the

  9. Global positioning system theory and practice

    CERN Document Server

    Hofmann-Wellenhof, Bernhard; Collins, James

    2001-01-01

    This book is dedicated to Dr. Benjamin William Remondi for many reasons. The project of writing a Global Positioning System (GPS) book was con­ ceived in April 1988 at a GPS meeting in Darmstadt, Germany. Dr. Remondi discussed with me the need for an additional GPS textbook and suggested a possible joint effort. In 1989, I was willing to commit myself to such a project. Unfortunately, the timing was less than ideal for Dr. Remondi. Therefore, I decided to start the project with other coauthors. Dr. Remondi agreed and indicated his willingness to be a reviewer. I selected Dr. Herbert Lichtenegger, my colleague from the Technical University Graz, Austria, and Dr. James Collins from Rockville, Maryland, U.S.A. In my opinion, the knowledge ofthe three authors should cover the wide spectrum of GPS. Dr. Lichtenegger is a geodesist with broad experience in both theory and practice. He has specialized his research to geodetic astron­ omy including orbital theory and geodynamical phenomena. Since 1986, Dr. Lichteneg...

  10. Genetic and biochemical changes of the serotonergic system in migraine pathobiology.

    Science.gov (United States)

    Gasparini, Claudia Francesca; Smith, Robert Anthony; Griffiths, Lyn Robyn

    2017-12-01

    Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the family in addition to the sufferer, particularly as it affects three times more women than men and is most prevalent between the ages of 25 and 45, the years of child rearing. Migraine typically occurs in individuals with a genetic predisposition and is aggravated by specific environmental triggers. Attempts to study the biochemistry of migraine began as early as the 1960s and were primarily directed at serotonin metabolism after an increase of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin was observed in urine of migraineurs. Genetic and biochemical studies have primarily focused on the neurotransmitter serotonin, considering receptor binding, transport and synthesis of serotonin and have investigated serotonergic mediators including enzymes, receptors as well as intermediary metabolites. These studies have been mainly assayed in blood, CSF and urine as the most accessible fluids. More recently PET imaging technology integrated with a metabolomics and a systems biology platform are being applied to study serotonergic biology. The general trend observed is that migraine patients have alterations of neurotransmitter metabolism detected in biological fluids with different biochemistry from controls, however the interpretation of the biological significance of these peripheral changes is unresolved. In this review we present the biology of the serotonergic system and metabolic routes for serotonin and discuss results of biochemical studies with regard to alterations in serotonin in brain, cerebrospinal fluid, saliva, platelets, plasma and urine of migraine patients.

  11. The scope and limitations of Von Bertalanffy's systems theory ...

    African Journals Online (AJOL)

    The Systems Theory is a complex theory (yet it is not identical to recent theories of complexity). The intention of this qualification is to demonstrate that the concept of a system is a complex basic concept of scientific thinking. This means that it is defined in terms of various elementary basic concepts brought together in its ...

  12. Collaborative Control Theory and Decision Support Systems

    Directory of Open Access Journals (Sweden)

    Shimon Y. Nof

    2017-08-01

    Full Text Available Collaborative Decision Support Systems, CDSS, depend on cost-effective collaboration among the decision participants. Those may include, in addition to human decision makers, non-human entities such as robots, software and hardware agents, sensors, and autonomous instruments. The purpose of this article is to explore the impact that CCT, the Collaborative Control Theory, has on cyber supported augmentation of collaboration in general, and its proven and potential impacts on CDSS in particular. Three recent case studies are discussed. The correlation between CDSS decision process and quality; and the level of CCT-based collaboration augmentation and the resulting level of Collaborative Intelligence, CI, is presented. It is concluded that while there are clear positive impacts of CCT based augmentation and level of CI, they need to be measured and optimized, not maximized. Further research in this area is also described.

  13. General Open Systems Theory and the Substrata-Factor Theory of Reading.

    Science.gov (United States)

    Kling, Martin

    This study was designed to extend the generality of the Substrata-Factor Theory by two methods of investigation: (1) theoretically, to est"blish the validity of the hypothesis that an isomorphic relationship exists between the Substrata-Factor Theory and the General Open Systems Theory, and (2) experimentally, to disc"ver through a…

  14. Complex Systems: An Introduction-Information Theory, Chaos ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 8. Complex Systems: An Introduction - Information Theory, Chaos Theory and Computational Complexity. V K Wadhawan. General Article Volume 14 Issue 8 August 2009 pp 761-781 ...

  15. System Dynamics as Model-Based Theory Building

    OpenAIRE

    Schwaninger, Markus; Grösser, Stefan N.

    2008-01-01

    This paper introduces model-based theory building as a feature of system dynamics (SD) with large potential. It presents a systemic approach to actualizing that potential, thereby opening up a new perspective on theory building in the social sciences. The question addressed is if and how SD enables the construction of high-quality theories. This contribution is based on field experiment type projects which have been focused on model-based theory building, specifically the construction of a mi...

  16. Theory of Neural Information Processing Systems

    International Nuclear Information System (INIS)

    Galla, Tobias

    2006-01-01

    It is difficult not to be amazed by the ability of the human brain to process, to structure and to memorize information. Even by the toughest standards the behaviour of this network of about 10 11 neurons qualifies as complex, and both the scientific community and the public take great interest in the growing field of neuroscience. The scientific endeavour to learn more about the function of the brain as an information processing system is here a truly interdisciplinary one, with important contributions from biology, computer science, physics, engineering and mathematics as the authors quite rightly point out in the introduction of their book. The role of the theoretical disciplines here is to provide mathematical models of information processing systems and the tools to study them. These models and tools are at the centre of the material covered in the book by Coolen, Kuehn and Sollich. The book is divided into five parts, providing basic introductory material on neural network models as well as the details of advanced techniques to study them. A mathematical appendix complements the main text. The range of topics is extremely broad, still the presentation is concise and the book well arranged. To stress the breadth of the book let me just mention a few keywords here: the material ranges from the basics of perceptrons and recurrent network architectures to more advanced aspects such as Bayesian learning and support vector machines; Shannon's theory of information and the definition of entropy are discussed, and a chapter on Amari's information geometry is not missing either. Finally the statistical mechanics chapters cover Gardner theory and the replica analysis of the Hopfield model, not without being preceded by a brief introduction of the basic concepts of equilibrium statistical physics. The book also contains a part on effective theories of the macroscopic dynamics of neural networks. Many dynamical aspects of neural networks are usually hard to find in the

  17. The S-Lagrangian and a theory of homeostasis in living systems

    Science.gov (United States)

    Sandler, U.; Tsitolovsky, L.

    2017-04-01

    A major paradox of living things is their ability to actively counteract degradation in a continuously changing environment or being injured through homeostatic protection. In this study, we propose a dynamic theory of homeostasis based on a generalized Lagrangian approach (S-Lagrangian), which can be equally applied to physical and nonphysical systems. Following discoverer of homeostasis Cannon (1935), we assume that homeostasis results from tendency of the organisms to decrease of the stress and avoid of death. We show that the universality of homeostasis is a consequence of analytical properties of the S-Lagrangian, while peculiarities of the biochemical and physiological mechanisms of homeostasis determine phenomenological parameters of the S-Lagrangian. Additionally, we reveal that plausible assumptions about S-Lagrangian features lead to good agreement between theoretical descriptions and observed homeostatic behavior. Here, we have focused on homeostasis of living systems, however, the proposed theory is also capable of being extended to social systems.

  18. Biochemical Contributions to Corrosion of Carbon Steel and Alloy 22 in a Continual Flow System

    International Nuclear Information System (INIS)

    Horn, J.; Martin, S.; Masterson, B.; Lian, T.

    1998-01-01

    Microbiologically influenced corrosion (MIC) may decrease the functional lifetime of nuclear waste packaging materials in the potential geologic repository at Yucca Mountain (YM), Nevada. Biochemical contributions to corrosion of package materials are being determined in reactors containing crushed repository-site rock with the endogenous microbial community, and candidate waste package materials. These systems are being continually supplied with simulated ground water. Periodically, bulk chemistries are analyzed on the system outflow, and surfacial chemistries are assessed on withdrawn material coupons. Both Fe and Mn dissolved from C1020 coupons under conditions that included the presence of YM microorganisms. Insoluble corrosion products remained in a reduced state at the coupon surface, indicating at least a localized anoxic condition; soluble reduced Mn and Fe were also detected in solution, while precipitated and spalled products were oxidized. Alloy 22 surfaces showed a layer of chrome oxide, almost certainly in the Cr(III) oxidation state, on microcosm-exposed coupons, while no soluble chrome was detected in solution. The results of these studies will be compared to identical testing on systems containing sterilized rock to generate, and ultimately predict, microbial contributions to waste package corrosion chemistries

  19. Development of a system for characterizing biomass quality of lignocellulosic feedstocks for biochemical conversion

    Science.gov (United States)

    Murphy, Patrick Thomas

    The purpose of this research was twofold: (i) to develop a system for screening lignocellulosic biomass feedstocks for biochemical conversion to biofuels and (ii) to evaluate brown midrib corn stover as feedstock for ethanol production. In the first study (Chapter 2), we investigated the potential of corn stover from bm1-4 hybrids for increased ethanol production and reduced pretreatment intensity compared to corn stover from the isogenic normal hybrid. Corn stover from hybrid W64A X A619 and respective isogenic bm hybrids was pretreated by aqueous ammonia steeping using ammonium hydroxide concentrations from 0 to 30%, by weight, and the resulting residues underwent simultaneous saccharification and cofermentation (SSCF) to ethanol. Dry matter (DM) digested by SSCF increased with increasing ammonium hydroxide concentration across all genotypes (P>0.0001) from 277 g kg-1 DM in the control to 439 g kg-1 DM in the 30% ammonium hydroxide pretreatment. The bm corn stover materials averaged 373 g kg-1 DM of DM digested by SSCF compared with 335 g kg-1 DM for the normal corn stover (PHTP) modifications to the original assay methods, including (i) using filter bags with batch sample processing, (ii) replacement of AIR with neutral detergent fiber (NDF) as a cell-wall isolation procedure, and (iii) elimination of the fermentation organism in the SSCF procedures used to determine biochemically available carbohydrates. The original and the HTP assay methods were compared using corn cobs, hybrid poplar, kenaf, and switchgrass. Biochemically available carbohydrates increased with the HTP methods in the corn cobs, hybrid poplar, and switchgrass, but remained the same in the kenaf. Total available carbohydrates increased and unavailable carbohydrates decreased with the HTP methods in the corn cobs and switchgrass and remained the same in the hybrid poplar and kenaf. There were no differences in total carbohydrates (CT) between the two methods. The final study evaluated the

  20. Dynamical systems theory for the Gardner equation

    Science.gov (United States)

    Saha, Aparna; Talukdar, B.; Chatterjee, Supriya

    2014-02-01

    The Gardner equation ut+auux+bu2ux+μuxxx=0 is a generic mathematical model for weakly nonlinear and weakly dispersive wave propagation when the effects of higher-order nonlinearity become significant. Using the so-called traveling wave ansatz u (x,t)=φ(ξ), ξ =x-vt (where v is the velocity of the wave) we convert the (1+1)-dimensional partial differential equation to a second-order ordinary differential equation in ϕ with an arbitrary constant and treat the latter equation by the methods of the dynamical systems theory. With some special attention on the equilibrium points of the equation, we derive an analytical constraint for admissible values of the parameters a, b, and μ. From the Hamiltonian form of the system we confirm that, in addition to the usual bright soliton solution, the equation can be used to generate three different varieties of internal waves of which one is a dark soliton recently observed in water [A. Chabchoub et al., Phys. Rev. Lett. 110, 124101 (2013), 10.1103/PhysRevLett.110.124101].

  1. Solar-System Tests of Gravitational Theories

    Science.gov (United States)

    Shapiro, Irwin

    1997-01-01

    We are engaged in testing gravitational theory by means of observations of objects in the solar system. These tests include an examination of the Principle Of Equivalence (POE), the Shapiro delay, the advances of planetary perihelia, the possibility of a secular variation G in the "gravitational constant" G, and the rate of the de Sitter (geodetic) precession of the Earth-Moon system. These results are consistent with our preliminary results focusing on the contribution of Lunar Laser Ranging (LLR), which were presented at the seventh Marcel Grossmann meeting on general relativity. The largest improvement over previous results comes in the uncertainty for (eta): a factor of five better than our previous value. This improvement reflects the increasing strength of the LLR data. A similar analysis presented at the same meeting by a group at the Jet Propulsion Laboratory gave a similar result for (eta). Our value for (beta) represents our first such result determined simultaneously with the solar quadrupole moment from the dynamical data set. These results are being prepared for publication. We have shown how positions determined from different planetary ephemerides can be compared and how the combination of VLBI and pulse timing information can yield a direct tie between planetary and radio frames. We have continued to include new data in our analysis as they became available. Finally, we have made improvement in our analysis software (PEP) and ported it to a network of modern workstations from its former home on a "mainframe" computer.

  2. Life history constrains biochemical development in the highly specialized odontocete echolocation system.

    Science.gov (United States)

    Koopman, Heather N; Zahorodny, Zoey P

    2008-10-22

    The vertebrate head has undergone enormous modification from the features borne by early ancestors. The growth of skull bones has been well studied in many species, yet little is known about corresponding soft tissue development. Among mammals, some of the most unusual examples of cranial evolution exist in the toothed whales (odontocetes). Specialized fat bodies in toothed whale heads play important roles in sound transmission and reception. These fat bodies contain unique endogenous lipids, with favourable acoustic properties, arranged in highly organized, three-dimensional patterns. We link variation in developmental rates of acoustic fats with life-history strategy, using bottlenose dolphins and harbour porpoises. Porpoise acoustic fats attain adult configurations earlier (less than 1 year) and at a faster pace than dolphins. The accelerated lipid accumulation in porpoises reflects the earlier need for fully functional echolocation systems. Dolphins enjoy 3-6 years of maternal care; porpoises must achieve total independence by approximately nine months. Further, a stereotypic 'blueprint' for the spatial distribution of lipids is established prior to birth, demonstrating the highly conserved nature of the intricate biochemical arrangement in acoustic tissues. This system illustrates an unusual case of soft tissue development being constrained by life history, rather than the more commonly observed mechanistic or phyletic constraints.

  3. A critical appraisal of the phene-plate biochemical fingerprinting system for epidemiological subtyping of Salmonella typhimurium

    DEFF Research Database (Denmark)

    On, S.L.W.; Baggesen, Dorte Lau

    1996-01-01

    The efficacy and reproducibility of the Phene-Plate (PhP) system (Biosys Inova, Stockholm, Sweden) for biochemical fingerprinting of Salmonella typhimurium was investigated. Duplicate and replicate assays on 40 epidemiologically related and unrelated strains were performed in two batches of PhP-48...

  4. Parallel Evolution in Science: The Historical Roots and Central Concepts of General Systems Theory; and "General Systems Theory,""Modern Organizational Theory," and Organizational Communication.

    Science.gov (United States)

    Lederman, Linda Costigan; Rogers, Don

    The two papers in this document focus on general systems theory. In her paper, Linda Lederman discusses the emergence and evolution of general systems theory, defines its central concepts, and draws some conclusions regarding the nature of the theory and its value as an epistemology. Don Rogers, in his paper, relates some of the important features…

  5. Incorporating learning theory into existing systems engineering models

    OpenAIRE

    Leo, Valentine

    2013-01-01

    Approved for public release; distribution is unlimited Systems engineering and learning theories are two major disciplines that involve preparing people to solve problems. While learning theories and their elements are apparent in the field of systems engineering, limited work has been performed on the interactions and relationship between these two disciplines. This thesis aims to establish and discuss a relationship between systems engineering and learning theories over the key phases of...

  6. Some open problems in random matrix theory and the theory of integrable systems

    OpenAIRE

    Deift, Percy

    2007-01-01

    We describe a list of open problems in random matrix theory and integrable systems which was presented at the conference ``Integrable Systems, Random Matrices, and Applications'' at the Courant Institute in May 2006.

  7. Postmodern Fuzzy System Theory: A Deconstruction Approach Based on Kabbalah

    Directory of Open Access Journals (Sweden)

    Gabriel Burstein

    2014-11-01

    Full Text Available Modern general system theory proposed a holistic integrative approach based on input-state-output dynamics as opposed to the traditional reductionist detail based approach. Information complexity and uncertainty required a fuzzy system theory, based on fuzzy sets and fuzzy logic. While successful in dealing with analysis, synthesis and control of technical engineering systems, general system theory and fuzzy system theory could not fully deal with humanistic and human-like intelligent systems which combine technical engineering components with human or human-like components characterized by their cognitive, emotional/motivational and behavioral/action levels of operation. Such humanistic systems are essential in artificial intelligence, cognitive and behavioral science applications, organization management and social systems, man-machine systems or human factor systems, behavioral knowledge based economics and finance applications. We are introducing here a “postmodern fuzzy system theory” for controlled state dynamics and output fuzzy systems and fuzzy rule based systems using our earlier postmodern fuzzy set theory and a Kabbalah possible worlds model of modal logic and semantics type. In order to create a postmodern fuzzy system theory, we “deconstruct” a fuzzy system in order to incorporate in it the cognitive, emotional and behavioral actions and expressions levels characteristic for humanistic systems. Kabbalah offers a structural, fractal and hierarchic model for integrating cognition, emotions and behavior. We obtain a canonic deconstruction for a fuzzy system into its cognitive, emotional and behavioral fuzzy subsystems.

  8. Mathematical Systems Theory : from Behaviors to Nonlinear Control

    CERN Document Server

    Julius, A; Pasumarthy, Ramkrishna; Rapisarda, Paolo; Scherpen, Jacquelien

    2015-01-01

    This treatment of modern topics related to mathematical systems theory forms the proceedings of a workshop, Mathematical Systems Theory: From Behaviors to Nonlinear Control, held at the University of Groningen in July 2015. The workshop celebrated the work of Professors Arjan van der Schaft and Harry Trentelman, honouring their 60th Birthdays. The first volume of this two-volume work covers a variety of topics related to nonlinear and hybrid control systems. After giving a detailed account of the state of the art in the related topic, each chapter presents new results and discusses new directions. As such, this volume provides a broad picture of the theory of nonlinear and hybrid control systems for scientists and engineers with an interest in the interdisciplinary field of systems and control theory. The reader will benefit from the expert participants’ ideas on exciting new approaches to control and system theory and their predictions of future directions for the subject that were discussed at the worksho...

  9. Hierarchical graphs for better annotations of rule-based models of biochemical systems

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Bin [Los Alamos National Laboratory; Hlavacek, William [Los Alamos National Laboratory

    2009-01-01

    In the graph-based formalism of the BioNetGen language (BNGL), graphs are used to represent molecules, with a colored vertex representing a component of a molecule, a vertex label representing the internal state of a component, and an edge representing a bond between components. Components of a molecule share the same color. Furthermore, graph-rewriting rules are used to represent molecular interactions, with a rule that specifies addition (removal) of an edge representing a class of association (dissociation) reactions and with a rule that specifies a change of vertex label representing a class of reactions that affect the internal state of a molecular component. A set of rules comprises a mathematical/computational model that can be used to determine, through various means, the system-level dynamics of molecular interactions in a biochemical system. Here, for purposes of model annotation, we propose an extension of BNGL that involves the use of hierarchical graphs to represent (1) relationships among components and subcomponents of molecules and (2) relationships among classes of reactions defined by rules. We illustrate how hierarchical graphs can be used to naturally document the structural organization of the functional components and subcomponents of two proteins: the protein tyrosine kinase Lck and the T cell receptor (TCR)/CD3 complex. Likewise, we illustrate how hierarchical graphs can be used to document the similarity of two related rules for kinase-catalyzed phosphorylation of a protein substrate. We also demonstrate how a hierarchical graph representing a protein can be encoded in an XML-based format.

  10. A general sensitivity theory for simulations of nonlinear systems

    International Nuclear Information System (INIS)

    Kenton, M.A.

    1981-01-01

    A general sensitivity theory is developed for nonlinear lumped-parameter system simulations. The point-of-departure is general perturbation theory, which has long been used for linear systems in nuclear engineering and reactor physics. The theory allows the sensitivity of particular figures-of-merit of the system behavior to be calculated with respect to any parameter.An explicit procedure is derived for applying the theory to physical systems undergoing sudden events (e.g., reactor scrams, tank ruptures). A related problem, treating figures-of-merit defined as functions of extremal values of system variables occurring at sudden events, is handled by the same procedure. The general calculational scheme for applying the theory to numerical codes is discussed. It is shown that codes which use pre-packaged implicit integration subroutines can be augmented to include sensitivity theory: a companion set of subroutines to solve the sensitivity problem is listed. This combined system analysis code is applied to a simple model for loss of post-accident heat removal in a liquid metal-cooled fast breeder reactor. The uses of the theory for answering more general sensitivity questions are discussed. One application of the theory is to systematically determine whether specific physical processes in a model contribute significantly to the figures-of-merit. Another application of the theory is for selecting parameter values which enable a model to match experimentally observed behavior

  11. Systems Theory, Unity of Effort, and Military Leadership

    Science.gov (United States)

    2012-12-14

    TITLE AND SUBTITLE Systems Theory , Unity of Effort, and Military Leadership 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...PAGE Name of Candidate: Major Lisa Livingood Thesis Title: Systems Theory , Unity of Effort and Military Leadership Approved by

  12. Theory of Technical Systems--Educational Tool for Engineering

    Science.gov (United States)

    Eder, Wolfgang Ernst

    2016-01-01

    Hubka's theory of technical systems (TTS) is briefly outlined. It describes commonalities in all engineering devices, whatever their physical principles of action. This theory is based on a general transformation system (TrfS), which can be used to show engineering in the contexts of society, economics and historic developments. The life cycle of…

  13. What can systems and control theory do for agricultural science?

    NARCIS (Netherlands)

    Straten, van G.

    2008-01-01

    Abstract: While many professionals with a background in agricultural and bio-resource sciences work with models, only few have been exposed to systems and control theory. The purpose of this paper is to elucidate a selection of methods from systems theory that can be beneficial to quantitative

  14. General Systems Theory Approaches to Organizations: Some Problems in Application

    Science.gov (United States)

    Peery, Newman S., Jr.

    1975-01-01

    Considers the limitations of General Systems Theory (GST) as a major paradigm within administrative theory and concludes that most systems formulations overemphasize growth and show little appreciation for intraorganizational conflict, diversity of values, and political action within organizations. Suggests that these limitations are mainly due to…

  15. Client-Controlled Case Information: A General System Theory Perspective

    Science.gov (United States)

    Fitch, Dale

    2004-01-01

    The author proposes a model for client control of case information via the World Wide Web built on principles of general system theory. It incorporates the client into the design, resulting in an information structure that differs from traditional human services information-sharing practices. Referencing general system theory, the concepts of…

  16. Theory of functional systems and human general pathology.

    Science.gov (United States)

    Khitrov, N K; Saltykov, A B

    2003-07-01

    We analyze the role of the theory of functional systems for human general pathology and the necessity of integration of this theory with the concepts of pathological and ambivalent systems. Multiple (qualitatively heterogeneous) nature of system-forming factors and principle possibility of the formation of physiological, pathological, and ambivalent systems by the same factors are discussed. These theses broaden the application of the theory of functional systems as the fundamental basis for studies of informational mechanisms of vital activity under normal and pathological conditions.

  17. Continuous and distributed systems theory and applications

    CERN Document Server

    Sadovnichiy, Victor

    2014-01-01

    In this volume, the authors close the gap between abstract mathematical approaches, such as abstract algebra, number theory, nonlinear functional analysis, partial differential equations, methods of nonlinear and multi-valued analysis, on the one hand, and practical applications in nonlinear mechanics, decision making theory and control theory on the other. Readers will also benefit from the presentation of modern mathematical modeling methods for the numerical solution of complicated engineering problems in hydromechanics, geophysics and mechanics of continua. This compilation will be of interest to mathematicians and engineers working at the interface of these field. It presents selected works of the open seminar series of Lomonosov Moscow State University and the National Technical University of Ukraine “Kyiv Polytechnic Institute”. The authors come from Germany, Italy, Spain, Russia, Ukraine, and the USA.

  18. The influence of different stocking densities on biochemical composition of rainbow trout meat reared in a recirculating aquaculture system

    Directory of Open Access Journals (Sweden)

    Mirela Cretu

    2014-10-01

    Full Text Available The aim of this study is to evaluate the biochemical composition of rainbow trout meat, reared in a recirculating aquaculture system, at different stocking densities (DS1-2,64 kg/m3, DS2-5,16 kg/m3, DS3-7,12 kg/m3, DS4-9,42 kg/m3. The analyses were performed in the research laboratory of Aquaculture, Environmental Science and Cadastre Department – Faculty of Food Science and Engineering, from ,,Dunarea de Jos’’University of Galati. The content of meat proteins, fats, dry substance and ash was determined. After a 33 days experimental trial, the biochemical analysis of meat from all four experimental variants shows that protein content was higher in DS1 and DS4 variants, while the smallest amount of fats was quantified at DS1 and DS2 variants, without significant differences (p >0.05 for none of the biochemical compounds analyzed, at the mean comparison on experimental variants. Thus, it can be concluded that biochemical composition of rainbow trout meat was not influenced by the tested stocking densities.

  19. Cu and Zn tolerance and responses of the Biochemical and Physiochemical system of Wheat

    Directory of Open Access Journals (Sweden)

    Kumar Vinod

    2012-08-01

    Full Text Available The concentrations of heavy metals such as Zinc and copper in the environment are currently increasing, due mainly to human activities. Zinc and copper are essential elements for several biochemical processes in plants. Any of these metals, at high concentrations in soil, can cause severe damage to physiological and biochemical activities of plants. Plant growth, pigment concentration, biochemical parameters, uptake of heavy metals were investigated in 30-days old wheat (Triticum aestivum L. in response to Cu and Zn stress. The plant exhibited a decline in growth, chlorophyll content, protein and DNA, RNA content carbohydrate, but proline, total phenol and H2O2 content increased at high concentration of Cu and Zn.

  20. Perturbation Theory for Open Two-Level Nonlinear Quantum Systems

    International Nuclear Information System (INIS)

    Zhang Zhijie; Jiang Dongguang; Wang Wei

    2011-01-01

    Perturbation theory is an important tool in quantum mechanics. In this paper, we extend the traditional perturbation theory to open nonlinear two-level systems, treating decoherence parameter γ as a perturbation. By this virtue, we give a perturbative solution to the master equation, which describes a nonlinear open quantum system. The results show that for small decoherence rate γ, the ratio of the nonlinear rate C to the tunneling coefficient V (i.e., r = C/V) determines the validity of the perturbation theory. For small ratio r, the perturbation theory is valid, otherwise it yields wrong results. (general)

  1. Growth of Lactobacillus paracasei ATCC 334 in a cheese model system: a biochemical approach.

    Science.gov (United States)

    Budinich, M F; Perez-Díaz, I; Cai, H; Rankin, S A; Broadbent, J R; Steele, J L

    2011-11-01

    Growth of Lactobacillus paracasei ATCC 334, in a cheese-ripening model system based upon a medium prepared from ripening Cheddar cheese extract (CCE) was evaluated. Lactobacillus paracasei ATCC 334 grows in CCE made from cheese ripened for 2 (2mCCE), 6 (6mCCE), and 8 (8mCCE) mo, to final cell densities of 5.9×10(8), 1.2×10(8), and 2.1×10(7)cfu/mL, respectively. Biochemical analysis and mass balance equations were used to determine substrate consumption patterns and products formed in 2mCCE. The products formed included formate, acetate, and D-lactate. These data allowed us to identify the pathways likely used and to initiate metabolic flux analysis. The production of volatiles during growth of Lb. paracasei ATCC 334 in 8mCCE was monitored to evaluate the metabolic pathways utilized by Lb. paracasei during the later stages of ripening Cheddar cheese. The 2 volatiles detected at high levels were ethanol and acetate. The remaining detected volatiles are present in significantly lower amounts and likely result from amino acid, pyruvate, and acetyl-coenzyme A metabolism. Carbon balance of galactose, lactose, citrate, and phosphoserine/phosphoserine-containing peptides in terms of D-lactate, acetate, and formate are in agreement with the amounts of substrates observed in 2mCCE; however, this was not the case for 6mCCE and 8mCCE, suggesting that additional energy sources are utilized during growth of Lb. paracasei ATCC 334 in these CCE. This study provides valuable information on the biochemistry and physiology of Lb. paracasei ATCC 334 in ripening cheese. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  2. Theories are knowledge organizing systems (KOS)

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2015-01-01

    The notion “theory” is a neglected concept in the field of information science and knowledge organization (KO) as well as generally in philosophy and in many other fields, although there are exceptions from this general neglect (e.g., the so-called “theory theory” in cognitive psychology...

  3. On activity theory in cognitive systems

    DEFF Research Database (Denmark)

    Abolfazlian, Ali Reza Kian

    Theory' (Virksomhedsteori). Virksomhedsteori er den dominante teori i den sovjetiske tradition af social psykologi. Virksomhedsteori startede med Vygotskys arbejde og fortsatte sin vækst under vejledningen af forskere som Leontiev og Luria. Med sit erkendelsesteoretiske program baseret på interaktion med...

  4. Personal Construct Theory and Systemic Therapies: Parallel or Convergent Trends?

    Science.gov (United States)

    Feixas, Guillem

    1990-01-01

    Explores similarities between Kelly's Personal Construct Theory (PCT) and systemic therapies. Asserts that (1) PCT and systemic therapies share common epistemological stance, constructivism; (2) personal construct systems possess properties of open systems; and (3) PCT and systemic therapies hold similar positions on relevant theoretical and…

  5. An Activity Systems Theory Approach to Agent Technology

    OpenAIRE

    Zhang, Peng; Bai, Guohua

    2005-01-01

    In the last decade, Activity Theory has been discussed a lot in Human-Computer Interaction (HCI) and Computer Supported Cooperative Work (CSCW). Activity Theory was used both theoretically as an analytical method and practically as a development framework for Information Systems. Meanwhile, there is a new trench from Artificial Intelligence. Artificial Intelligence researchers find that the fruit from Activity Theory study may contribute, especially to Agent Technology, with socio-psychologic...

  6. The Einstein-Vlasov System/Kinetic Theory.

    Science.gov (United States)

    Andréasson, Håkan

    2011-01-01

    The main purpose of this article is to provide a guide to theorems on global properties of solutions to the Einstein-Vlasov system. This system couples Einstein's equations to a kinetic matter model. Kinetic theory has been an important field of research during several decades in which the main focus has been on non-relativistic and special relativistic physics, i.e., to model the dynamics of neutral gases, plasmas, and Newtonian self-gravitating systems. In 1990, Rendall and Rein initiated a mathematical study of the Einstein-Vlasov system. Since then many theorems on global properties of solutions to this system have been established. This paper gives introductions to kinetic theory in non-curved spacetimes and then the Einstein-Vlasov system is introduced. We believe that a good understanding of kinetic theory in non-curved spacetimes is fundamental to a good comprehension of kinetic theory in general relativity.

  7. The Einstein-Vlasov System/Kinetic Theory

    Directory of Open Access Journals (Sweden)

    Håkan Andréasson

    2011-05-01

    Full Text Available The main purpose of this article is to provide a guide to theorems on global properties of solutions to the Einstein-Vlasov system. This system couples Einstein’s equations to a kinetic matter model. Kinetic theory has been an important field of research during several decades in which the main focus has been on non-relativistic and special relativistic physics, i.e., to model the dynamics of neutral gases, plasmas, and Newtonian self-gravitating systems. In 1990, Rendall and Rein initiated a mathematical study of the Einstein-Vlasov system. Since then many theorems on global properties of solutions to this system have been established. This paper gives introductions to kinetic theory in non-curved spacetimes and then the Einstein–Vlasov system is introduced. We believe that a good understanding of kinetic theory in non-curved spacetimes is fundamental to a good comprehension of kinetic theory in general relativity.

  8. A master equation and moment approach for biochemical systems with creation-time-dependent bimolecular rate functions

    Energy Technology Data Exchange (ETDEWEB)

    Chevalier, Michael W., E-mail: Michael.Chevalier@ucsf.edu; El-Samad, Hana, E-mail: Hana.El-Samad@ucsf.edu [Department of Biochemistry and Biophysics, California Institute for Quantitative Biosciences, University of California San Francisco, 1700 4th Street, San Francisco, California 94143-2542 (United States)

    2014-12-07

    Noise and stochasticity are fundamental to biology and derive from the very nature of biochemical reactions where thermal motion of molecules translates into randomness in the sequence and timing of reactions. This randomness leads to cell-to-cell variability even in clonal populations. Stochastic biochemical networks have been traditionally modeled as continuous-time discrete-state Markov processes whose probability density functions evolve according to a chemical master equation (CME). In diffusion reaction systems on membranes, the Markov formalism, which assumes constant reaction propensities is not directly appropriate. This is because the instantaneous propensity for a diffusion reaction to occur depends on the creation times of the molecules involved. In this work, we develop a chemical master equation for systems of this type. While this new CME is computationally intractable, we make rational dimensional reductions to form an approximate equation, whose moments are also derived and are shown to yield efficient, accurate results. This new framework forms a more general approach than the Markov CME and expands upon the realm of possible stochastic biochemical systems that can be efficiently modeled.

  9. Clinical Implications of Dynamic Systems Theory for Phonological Development

    Science.gov (United States)

    Rvachew, Susan; Bernhardt, Barbara May

    2010-01-01

    Purpose: To examine treatment outcomes in relation to the complexity of treatment goals for children with speech sound disorders. Method: The clinical implications of dynamic systems theory in contrast with learnability theory are discussed, especially in the context of target selection decisions for children with speech sound disorders. Detailed…

  10. Time-dependent density functional theory for periodic systems

    NARCIS (Netherlands)

    Kootstra, Freddie

    2001-01-01

    In this thesis the time-dependent version of density functional theory is described, which has been developed for crystalline non-metallic systems with periodicity in one to three dimensions. The application of this theory to the calculation of the optical reponse properties of a wide range of

  11. The sensitivity theory for inertial confinement pellet fusion system

    International Nuclear Information System (INIS)

    Cai, Shaohui; Zhang, Yuquan.

    1986-01-01

    A sensitivity theory for inertial confinement pellet fusion system is developed based on a physical model similar to that embodied in the laser fusion code MEDUSA. The theory presented here can be an efficient tool for estimating the effects of many alternations in the data field. Our result is different from Greenspan's work in 1980. (author)

  12. A denotational theory of synchronous reactive systems

    OpenAIRE

    Benveniste , Albert; Le Guernic , Paul; Sorel , Yves; Sorine , Michel

    1992-01-01

    International audience; In this paper, systems which interact permanently with their environments are considered. Such systems are encountered, for instance, in real-time control or signal processing systems, C3-systems, and man-machine interfaces, to mention just a few cases. The design and implementation of such systems require a concurrent programming language which can be used to verify and synthesize the synchronization mechanisms, and to perform transformations of the concurrent source ...

  13. Integrable Hamiltonian systems and spectral theory

    CERN Document Server

    Moser, J

    1981-01-01

    Classical integrable Hamiltonian systems and isospectral deformations ; geodesics on an ellipsoid and the mechanical system of C. Neumann ; the Schrödinger equation for almost periodic potentials ; finite band potentials ; limit cases, Bargmann potentials.

  14. Organizational and Systems Theory: An Integrated Review

    Science.gov (United States)

    1980-09-30

    symbiosis and the relatively isolated system. Symbiosis is the mutually bevieficial living together of two systems, neither of which is a subsystem of...economic trade-off for some reward or service which constitutes a cost for the first system, symbiosis exists. The relatively isolated system is a set...morale (Berrien,, 1976; DeGreene, 1974; Foster and Davis, "Le 1980; Ruben and Kim, 1975). Clark (1972) cautions that the planned change (OD

  15. Implicit Sociology, Interdisciplinarity and Systems Theories in Agricultural Science

    NARCIS (Netherlands)

    Jansen, K.

    2009-01-01

    Recurring political and economic crises in agriculture lie behind policymakers' demands for more interdisciplinary, problem-solving approaches. This article examines different systems theories in agricultural sciences that claim to adopt interdisciplinarity and to bridge a supposed gap between the

  16. Using institutional theory with sensemaking theory: a case study of information system implementation in healthcare

    DEFF Research Database (Denmark)

    Jensen, Tina Blegind; Kjærgaard, Annemette; Svejvig, Per

    2009-01-01

    Institutional theory has proven to be a central analytical perspective for investigating the role of social and historical structures of information systems (IS) implementation. However, it does not explicitly account for how organisational actors make sense of and enact technologies in their local...... context. We address this limitation by exploring the potential of using institutional theory with sensemaking theory to study IS implementation in organisations. We argue that each theoretical perspective has its own explanatory power and that a combination of the two facilitates a much richer...... interpretation of IS implementation by linking macro- and micro-levels of analysis. To illustrate this, we report from an empirical study of the implementation of an Electronic Patient Record (EPR) system in a clinical setting. Using key constructs from the two theories, our findings address the phenomenon...

  17. Modeling transonic aerodynamic response using nonlinear systems theory for use with modern control theory

    Science.gov (United States)

    Silva, Walter A.

    1993-01-01

    The presentation begins with a brief description of the motivation and approach that has been taken for this research. This will be followed by a description of the Volterra Theory of Nonlinear Systems and the CAP-TSD code which is an aeroelastic, transonic CFD (Computational Fluid Dynamics) code. The application of the Volterra theory to a CFD model and, more specifically, to a CAP-TSD model of a rectangular wing with a NACA 0012 airfoil section will be presented.

  18. Theory and practice in machining systems

    CERN Document Server

    Ito, Yoshimi

    2017-01-01

    This book describes machining technology from a wider perspective by considering it within the machining space. Machining technology is one of the metal removal activities that occur at the machining point within the machining space. The machining space consists of structural configuration entities, e.g., the main spindle, the turret head and attachments such the chuck and mandrel, and also the form-generating movement of the machine tool itself. The book describes fundamental topics, including the form-generating movement of the machine tool and the important roles of the attachments, before moving on to consider the supply of raw materials into the machining space, and the discharge of swarf from it, and then machining technology itself. Building on the latest research findings “Theory and Practice in Machining System” discusses current challenges in machining. Thus, with the inclusion of introductory and advanced topics, the book can be used as a guide and survey of machining technology for students an...

  19. Contraction theory based adaptive synchronization of chaotic systems

    International Nuclear Information System (INIS)

    Sharma, B.B.; Kar, I.N.

    2009-01-01

    Contraction theory based stability analysis exploits the incremental behavior of trajectories of a system with respect to each other. Application of contraction theory provides an alternative way for stability analysis of nonlinear systems. This paper considers the design of a control law for synchronization of certain class of chaotic systems based on backstepping technique. The controller is selected so as to make the error dynamics between the two systems contracting. Synchronization problem with and without uncertainty in system parameters is discussed and necessary stability proofs are worked out using contraction theory. Suitable adaptation laws for unknown parameters are proposed based on the contraction principle. The numerical simulations verify the synchronization of the chaotic systems. Also parameter estimates converge to their true values with the proposed adaptation laws.

  20. Hamilton-Jacobi theory of continuos systems

    International Nuclear Information System (INIS)

    Guler, Y.

    1987-01-01

    The Hamilton-Jacobi partial differential equation for classical field systems is obtained in a 5n-dimensional phase space and it is integrated by the method of characteristics. Space-time partial derivatives of Hamilton's principal functions S μ (Φ i , x v ) (μ, v = 1, 2, 3, 4) are identified as the energy-momentum tensor of the system

  1. Nonlinear dynamical systems for theory and research in ergonomics.

    Science.gov (United States)

    Guastello, Stephen J

    2017-02-01

    Nonlinear dynamical systems (NDS) theory offers new constructs, methods and explanations for phenomena that have in turn produced new paradigms of thinking within several disciplines of the behavioural sciences. This article explores the recent developments of NDS as a paradigm in ergonomics. The exposition includes its basic axioms, the primary constructs from elementary dynamics and so-called complexity theory, an overview of its methods, and growing areas of application within ergonomics. The applications considered here include: psychophysics, iconic displays, control theory, cognitive workload and fatigue, occupational accidents, resilience of systems, team coordination and synchronisation in systems. Although these applications make use of different subsets of NDS constructs, several of them share the general principles of the complex adaptive system. Practitioner Summary: Nonlinear dynamical systems theory reframes problems in ergonomics that involve complex systems as they change over time. The leading applications to date include psychophysics, control theory, cognitive workload and fatigue, biomechanics, occupational accidents, resilience of systems, team coordination and synchronisation of system components.

  2. A quest towards a mathematical theory of living systems

    CERN Document Server

    Bellomo, Nicola; Gibelli, Livio; Outada, Nisrine

    2017-01-01

    This monograph aims to lay the groundwork for the design of a unified mathematical approach to the modeling and analysis of large, complex systems composed of interacting living things. Drawing on twenty years of research in various scientific fields, it explores how mathematical kinetic theory and evolutionary game theory can be used to understand the complex interplay between mathematical sciences and the dynamics of living systems. The authors hope this will contribute to the development of new tools and strategies, if not a new mathematical theory. The first chapter discusses the main features of living systems and outlines a strategy for their modeling. The following chapters then explore some of the methods needed to potentially achieve this in practice. Chapter Two provides a brief introduction to the mathematical kinetic theory of classical particles, with special emphasis on the Boltzmann equation; the Enskog equation, mean field models, and Monte Carlo methods are also briefly covered. Chapter Three...

  3. Control theory of digitally networked dynamic systems

    CERN Document Server

    Lunze, Jan

    2013-01-01

    The book gives an introduction to networked control systems and describes new modeling paradigms, analysis methods for event-driven, digitally networked systems, and design methods for distributed estimation and control. Networked model predictive control is developed as a means to tolerate time delays and packet loss brought about by the communication network. In event-based control the traditional periodic sampling is replaced by state-dependent triggering schemes. Novel methods for multi-agent systems ensure complete or clustered synchrony of agents with identical or with individual dynamic

  4. Theory of control systems described by differential inclusions

    CERN Document Server

    Han, Zhengzhi; Huang, Jun

    2016-01-01

    This book provides a brief introduction to the theory of finite dimensional differential inclusions, and deals in depth with control of three kinds of differential inclusion systems. The authors introduce the algebraic decomposition of convex processes, the stabilization of polytopic systems, and observations of Luré systems. They also introduce the elemental theory of finite dimensional differential inclusions, and the properties and designs of the control systems described by differential inclusions. Addressing the material with clarity and simplicity, the book includes recent research achievements and spans all concepts, concluding with a critical mathematical framework. This book is intended for researchers, teachers and postgraduate students in the area of automatic control engineering.

  5. Mirror theory applied to toroidal systems

    International Nuclear Information System (INIS)

    Cohen, R.H.

    1987-01-01

    Central features of a mirror plasma are strong departures from Maxwellian distribution functions, ambipolar potentials and densities which vary along a field line, end losses, and the mirror field itself. To examine these features, mirror theorists have developed analytical and numerical techniques to solve the Fokker-Planck equation, evaluate the potentials consistent with the resulting distribution functions, and assess the microstability of these distributions. Various combinations of mirror-plasma features are present and important in toroidal plasmas as well, particularly in the edge region and in plasmas with strong rf heating. In this paper we survey problems in toroidal plasmas where mirror theory and computational techniques are applicable, and discuss in more detail three specific examples: calculation of the toroidal generalization of the Spitzer-Haerm distribution function (from which trapped-particle effects on current drive can be calculated), evaluation of the nonuniform potential and density set up by pulsed electron-cyclotron heating, and calculation of steady-state distribution functions in the presence of strong rf heating and collisions. 37 refs

  6. Cable system transients theory, modeling and simulation

    CERN Document Server

    Ametani, Akihiro; Nagaoka, Naoto

    2015-01-01

    A systematic and comprehensive introduction to electromagnetic transient in cable systems, written by the internationally renowned pioneer in this field Presents a systematic and comprehensive introduction to electromagnetic transient in cable systems Written by the internationally renowned pioneer in the field Thorough coverage of the state of the art on the topic, presented in a well-organized, logical style, from fundamentals and practical applications A companion website is available

  7. Theory of uniqueness of Indian Caste System

    OpenAIRE

    Ashwin Kumar

    2006-01-01

    Classical studies on pre-modern Indian social structure have suggested apparent differences between the Indian caste system and social stratification as one can discern in other parts of the world. However, one needs to question such dogmatic assertions that such vast differences really existed. An endeavor is made in this research paper to reflect on the nature of caste hierarchy in pre-modern India. The caste system forms the significant basis of pre-modern Indian social structure. Early wr...

  8. Biochemical markers of the functional disorders of the liver in patients with systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    L.F. Bogmat

    2017-05-01

    Full Text Available Background. Systemic lupus erythematosus (SLE in the basis of the pathogenesis has generalized autoimmune inflammation, which leads to the development of a wide range of immune-inflammatory organ disorders. Among them, the liver deserves special attention, since its functional state can reflect not only the severity of the pathological process, but also the response on aggressive treatment. The purpose of the work was studying the biochemical markers of the functional state of the liver in children with initial stages of SLE. Materials and methods. Features of the lipid, carbohydrate spectrum of the blood, indicators of pigment exchange, markers of cytolysis, cholestasis, fibrosis and protein-synthetic function of the liver were studied in children and adolescents with SLE. Twenty six patients aged 7–18 years were examined. Two groups were formed: 10 patients (38.4 % with the duration of the disease of 1–3 years and 16 people (61.5 % with duration of more than 3 years. Results. The average blood lipids levels did not exceed the reference values and did not have statistical differences among the patients of the selected groups. The levels of total cholesterol and triglycerides in both groups of patients significantly exceeded the control values (p < 0.05. Indicators of low density lipoprotein cholesterol increased already in the early stages of the disease (p < 0.05 and reached the maximum values in individuals with a course of SLE over 3 years (p < 0.05. Concentration of high density lipoprotein cholesterol in patients of the second group decreased somewhat (p < 0.1. There was an increase in the average values of atherogenic index by 1.7 times among patients in the first group (p < 0.05 and 2.25 times in persons from the second group (p < 0.05. Studies of other metabolic links showed that the average values of glycaemia and immunoreactive insulin (IRI were consistent with the physiological norm. However, half of patients with SLE had

  9. Residue number systems theory and applications

    CERN Document Server

    Mohan, P V Ananda

    2016-01-01

    This new and expanded monograph improves upon Mohan's earlier book, Residue Number Systems (Springer, 2002) with a state of the art treatment of the subject. Replete with detailed illustrations and helpful examples, this book covers a host of cutting edge topics such as the core function, the quotient function, new Chinese Remainder theorems, and large integer operations. It also features many significant applications to practical communication systems and cryptography such as FIR filters and elliptic curve cryptography. Starting with a comprehensive introduction to the basics and leading up to current research trends that are not yet widely distributed in other publications, this book will be of interest to both researchers and students alike.

  10. A novel classification system for evolutionary aging theories.

    Science.gov (United States)

    Trindade, Lucas S; Aigaki, Toshiro; Peixoto, Alexandre A; Balduino, Alex; Mânica da Cruz, Ivana B; Heddle, Jonathan G

    2013-01-01

    Theories of lifespan evolution are a source of confusion amongst aging researchers. After a century of aging research the dispute over whether the aging process is active or passive persists and a comprehensive and universally accepted theoretical model remains elusive. Evolutionary aging theories primarily dispute whether the aging process is exclusively adapted to favor the kin or exclusively non-adapted to favor the individual. Interestingly, contradictory data and theories supporting both exclusively programmed and exclusively non-programmed theories continue to grow. However, this is a false dichotomy; natural selection favors traits resulting in efficient reproduction whether they benefit the individual or the kin. Thus, to understand the evolution of aging, first we must understand the environment-dependent balance between the advantages and disadvantages of extended lifespan in the process of spreading genes. As described by distinct theories, different niches and environmental conditions confer on extended lifespan a range of fitness values varying from highly beneficial to highly detrimental. Here, we considered the range of fitness values for extended lifespan and develop a fitness-based framework for categorizing existing theories. We show that all theories can be classified into four basic types: secondary (beneficial), maladaptive (neutral), assisted death (detrimental), and senemorphic aging (varying between beneficial to detrimental). We anticipate that this classification system will assist with understanding and interpreting aging/death by providing a way of considering theories as members of one of these classes rather than consideration of their individual details.

  11. Towards a Systemic Theory of Gifted Education

    Science.gov (United States)

    Ziegler, Albert; Phillipson, Shane N.

    2012-01-01

    In this target article, we argue that current approaches to gifted education are based on the erroneous view that to understand the development of exceptionality we need to understand firstly the components of giftedness, including cognitive such as intelligence and non-cognitive factors such as motivation. In contrast, systemic approaches to…

  12. Bisimulation theory for switching linear systems

    NARCIS (Netherlands)

    Pola, G.; van der Schaft, Arjan; Di Benedetto, Maria D.

    2004-01-01

    A general notion of hybrid bisimulation is proposed and related to the notions of algebraic, state-space and input-output equivalences for the class of switching linear systems. An algebraic characterization of hybrid bisimulations and a procedure converging in a finite number of steps to the

  13. Distribution system reliability evaluation using credibility theory

    African Journals Online (AJOL)

    Xufeng Xu, Joydeep Mitra

    switches, the distribution system can be divided into multiple SPSS, which are connected with tie switches. For example, SPSS corresponding to feeder F1 in Figure 2 is composed of {1, 2,…, 12}. Secondly, based on the definition of SPSS, the power supply area of each feeder is analyzed by depth-first search strategy. The.

  14. Introduction to a systemic theory of meaning

    OpenAIRE

    Menant, Mr Christophe

    2001-01-01

    Information and meanings are present everywhere around us and within ourselves. Specific studies have been implemented in order to link information and meaning: - Semiotics/Biosemiotics - Phenomenology - Analytic Philosophy, linguistics - Psychology No general coverage is available for the notion of meaning. We propose to complement this lack by a systemic approach to meaning generation

  15. [Development of delusion in view of Luhmann's systems theory].

    Science.gov (United States)

    Maier, T

    2003-01-01

    The systems theory of Niklas Luhmann declares itself as a universal theory and therefore claims applicability to any social and psychic phenomenon.In spite of its high complexity, to many it seems too vague and nonspecific. The possible usefulness of this theory should be demonstrated on the example of the development of delusion, still a mysterious and unexplained phenomenon. Within the framework of Luhmann's systems theory, delusion can be considered a communication disorder and therefore a phenomenon within the social system. Both the autopoietic systems society and psyche are based on and processed by meaning but cannot communicate directly, and they are mutually nontransparent and unpredictable. Due to this fact, the interface between the two systems is a potential source of disturbances. Luhmann defines the distinction of information, message, and understanding as the crucial element to connect the social system with the psychic one. If the psychic system fails to recognize the message of an information correctly or is unable to negotiate between understanding and misunderstanding messages, it detaches itself from the social system to which it is normally closely connected. This detachment releases the possibility of unhindered autistic fulfillment of desires and uncontrolled fear. Due to the meaning-based autopoiesis of the psychic system,these released thoughts and emotions still appear in meaningfully condensed form as delusions.

  16. Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions.

    Science.gov (United States)

    Alarcon, R A

    2012-10-01

    A hypothesis suggesting the existence of a ubiquitous physiological anticancer system created by two highly reactive oxidative stress inducers with anticancer properties, acrolein and hydroxyl radical, is reported in this communication. Both components can originate separately or together in several biochemical interactions, among them, the enzymatic oxidation of the polyamine spermine, which appear to be their main source. The foundations of this hypothesis encompass our initial search for growth-inhibitors or anticancer compounds in biological material leading to the isolation of spermine, a polyamine that became highly cytotoxic through the generation of acrolein, when enzymatically oxidized. Findings complemented with pertinent literature data by other workers and observed anticancer activities by sources capable of producing acrolein and hydroxyl radical. This hypothesis obvious implication: spermine enzymatic oxidations or other biochemical interactions that would co-generate acrolein and hydroxyl radical, the anticancer system components, should be tried as treatments for any given cancer. The biochemical generation of acrolein observed was totally unexpected, since this aldehyde was known; as a very toxic and highly reactive xenobiotic chemical produced in the pyrolysis of fats and other organic material, found as an atmospheric pollutant, in tobacco smoke and car emissions, and mainly used as a pesticide or aquatic herbicide. Numerous studies on acrolein, considered after our work a biological product, as well, followed. In them, acrolein widespread presence, its effects on diverse cellular proteins, such as, growth factors, and its anticancer activities, were additionally reported. Regarding hydroxyl radical, the second component of the proposed anticancer system, and another cytotoxic product in normal cell metabolism, it co-generates with acrolein in several biochemical interactions, occurrences suggesting that these products might jointly fulfill some

  17. A critical appraisal of the phene-plate biochemical fingerprinting system for epidemiological subtyping of Salmonella typhimurium

    DEFF Research Database (Denmark)

    On, S.L.W.; Baggesen, Dorte Lau

    1996-01-01

    The efficacy and reproducibility of the Phene-Plate (PhP) system (Biosys Inova, Stockholm, Sweden) for biochemical fingerprinting of Salmonella typhimurium was investigated. Duplicate and replicate assays on 40 epidemiologically related and unrelated strains were performed in two batches of PhP-48......P-types which are epidemiologically unjustified, (ii) tests currently recommended for PhP-typing S. typhimurium may be somewhat unstable and not satisfactory for fingerprinting purposes, (iii) caution must be exercised when comparing data from different batches of PhP-48 plates, and (iv) best results...

  18. On nonequilibrium many-body systems III: nonlinear transport theory

    International Nuclear Information System (INIS)

    Luzzi, R.; Vasconcellos, A.R.; Algarte, A.C.S.

    1986-01-01

    A nonlinear transport theory for many-body systems arbitrarily away from equilibrium, based on the nonequilibrium statistical operator (NSO) method, is presented. Nonlinear transport equations for a basis set of dynamical quantities are derived using two equivalent treatments that may be considered far reaching generalizations of the Hilbert-Chapman-Enskog method and Mori's generalized Langevin equations method. The first case is considered in some detail and the general characteristics of the theory are discussed. (Author) [pt

  19. A monequillibrium mary-body systems IV: Respouse function theory

    International Nuclear Information System (INIS)

    Luzzi, R.; Vasconcellos, A.R.; Algarte, A.C.S.

    1987-01-01

    A response function theory for many-body systems arbitrarily away from equilibrium is presented. It is based on the nonequilibrium statistical operator method fully described in a previous article. A formal theory is presented evaluation of transition probabilties and the average values of dynamical quantities in far-from-equilibrium many-body systems under the action of external perturbations. A nonequilibrium thermodynamic Green's function algorithn appropriate for the calculation of response functions and scattering cross sections in terms of a generalized fluctuation-dissipation theorem for far-from-equilibrium systems is also derived. (author) [pt

  20. On nonlinear inner systems and connections with control theory

    NARCIS (Netherlands)

    Petersen, Mark A.; van der Schaft, Arjan

    2002-01-01

    This paper extends some results involving linear inner systems to the nonlinear case. In thsi regard, the arithmetic of nonlinear inner systems is developed further and some new connections with nonlinear spectral and all-pass factorization and control theory are discussed. In particular, explicit

  1. Theories about architecture and performance of multi-agent systems

    NARCIS (Netherlands)

    Gazendam, H.W.M.; Jorna, René J.

    1998-01-01

    Multi-agent systems are promising as models of organization because they are based on the idea that most work in human organizations is done based on intelligence, communication, cooperation, and massive parallel processing. They offer an alternative for system theories of organization, which are

  2. What Should Instructional Designers Know about General Systems Theory?

    Science.gov (United States)

    Salisbury, David F.

    1989-01-01

    Describes basic concepts in the field of general systems theory (GST) and explains the relationship between instructional systems design (ISD) and GST. Benefits of integrating GST into the curriculum of ISD graduate programs are discussed, and a short bibliography on GST is included. (LRW)

  3. Quantum theory of many-particle systems

    CERN Document Server

    Fetter, Alexander L

    2003-01-01

    ""Singlemindedly devoted to its job of educating potential many-particle theorists…deserves to become the standard text in the field."" - Physics Today""The most comprehensive textbook yet published in its field and every postgraduate student or teacher in this field should own or have access to a copy."" - EndeavorA self-contained, unified treatment of nonrelativistic many-particle systems, this text offers a solid introduction to procedures in a manner that enables students to adopt techniques for their own use. Its discussions of formalism and applications move easily between general theo

  4. Systems theory and cascades in developmental psychopathology.

    Science.gov (United States)

    Cox, Martha J; Mills-Koonce, Roger; Propper, Cathi; Gariépy, Jean-Louis

    2010-08-01

    In the wake of prominent theoreticians in developmental science, whose contributions we review in this article, many developmental psychologists came to endorse a systems approach to understanding how the individual, as it develops, establishes functional relationships to social ecological contexts that from birth to school entry rapidly increase in complexity. The concept of developmental cascade has been introduced in this context to describe lawful processes by which antecedent conditions may be related with varying probabilities to specified outcomes. These are understood as processes by which function at one level or in one domain of behavior affect the organization of competency in later developing domains of general adaptation. Here we propose a developmental sequence by which the developing child acquires regulative capacities that are key to adjustment to a society that demands considerable control of emotional and cognitive functions early in life. We report empirical evidence showing that the acquisition of regulative capacities may be understood as a cascade of shifts in control parameters induced by the progressive integration of biological, transactional, and socioaffective systems over development. We conclude by suggesting how the developmental process may be accessed for effective intervention in populations deemed "at risk" for later problems of psychosocial adjustment.

  5. Anthropocentric language theory and Serbian case systems

    Directory of Open Access Journals (Sweden)

    Topolinjska Zuzana

    2002-01-01

    Full Text Available The author understands case as a relationship of syntactic dependence between a subordinated noun phrase and the governing syntactic construction (predicative expression and/or another noun phrase. The above definition construes case as a universal category characteristics of all the languages sharing the nomen vs verbum opposition. Particular cases are conceived as primarily semantically motivated. The two relevant semantic parameters are /+/ -human / (or /+/ -animated/ and /+/ -localized/, i. e. - in other words - the so-called hierarchy of animateness and the spatial location of the objects that the corresponding noun phrases refer to. N and D are being characterized as /+ hum/, A and I as /-hum/ and L as belonging to another semantic paradigm is defined simply as /+ loc/. Results of the analyses of morphological syncretism's and of syntactic exponents of the NPs-dependence found in Serbian case systems support the above tentative interpretation of the case as a (semantic and syntactic category.

  6. Open-system Kohn-Sham density functional theory.

    Science.gov (United States)

    Zhou, Yongxi; Ernzerhof, Matthias

    2012-03-07

    A simple model for electron transport through molecules is provided by the source-sink potential (SSP) method [F. Goyer, M. Ernzerhof, and M. Zhuang, J. Chem. Phys. 126, 144104 (2007)]. In SSP, the boundary conditions of having an incoming and outgoing electron current are enforced through complex potentials that are added to the Hamiltonian. Depending on the sign of the imaginary part of the potentials, current density is generated or absorbed. In this way, a finite system can be used to model infinite molecular electronic devices. The SSP has originally been developed for the Hückel method and subsequently it has been extended [F. Goyer and M. Ernzerhof, J. Chem. Phys. 134, 174101 (2011)] to the Hubbard model. Here we present a step towards its generalization for first-principles electronic structure theory methods. In particular, drawing on our earlier work, we discuss a new generalized density functional theory for complex non-Hermitian Hamiltonians. This theory enables us to combine SSP and Kohn-Sham theory to obtain a method for the description of open systems that exchange current density with their environment. Similarly, the Hartree-Fock method is extended to the realm of non-Hermitian, SSP containing Hamiltonians. As a proof of principle, we present the first applications of complex-density functional theory (CODFT) as well as non-Hermitian Hartree-Fock theory to electron transport through molecules. © 2012 American Institute of Physics

  7. Extending density functional embedding theory for covalently bonded systems.

    Science.gov (United States)

    Yu, Kuang; Carter, Emily A

    2017-12-19

    Quantum embedding theory aims to provide an efficient solution to obtain accurate electronic energies for systems too large for full-scale, high-level quantum calculations. It adopts a hierarchical approach that divides the total system into a small embedded region and a larger environment, using different levels of theory to describe each part. Previously, we developed a density-based quantum embedding theory called density functional embedding theory (DFET), which achieved considerable success in metals and semiconductors. In this work, we extend DFET into a density-matrix-based nonlocal form, enabling DFET to study the stronger quantum couplings between covalently bonded subsystems. We name this theory density-matrix functional embedding theory (DMFET), and we demonstrate its performance in several test examples that resemble various real applications in both chemistry and biochemistry. DMFET gives excellent results in all cases tested thus far, including predicting isomerization energies, proton transfer energies, and highest occupied molecular orbital-lowest unoccupied molecular orbital gaps for local chromophores. Here, we show that DMFET systematically improves the quality of the results compared with the widely used state-of-the-art methods, such as the simple capped cluster model or the widely used ONIOM method.

  8. Product Distribution Theory for Control of Multi-Agent Systems

    Science.gov (United States)

    Lee, Chia Fan; Wolpert, David H.

    2004-01-01

    Product Distribution (PD) theory is a new framework for controlling Multi-Agent Systems (MAS's). First we review one motivation of PD theory, as the information-theoretic extension of conventional full-rationality game theory to the case of bounded rational agents. In this extension the equilibrium of the game is the optimizer of a Lagrangian of the (probability distribution of) the joint stare of the agents. Accordingly we can consider a team game in which the shared utility is a performance measure of the behavior of the MAS. For such a scenario the game is at equilibrium - the Lagrangian is optimized - when the joint distribution of the agents optimizes the system's expected performance. One common way to find that equilibrium is to have each agent run a reinforcement learning algorithm. Here we investigate the alternative of exploiting PD theory to run gradient descent on the Lagrangian. We present computer experiments validating some of the predictions of PD theory for how best to do that gradient descent. We also demonstrate how PD theory can improve performance even when we are not allowed to rerun the MAS from different initial conditions, a requirement implicit in some previous work.

  9. Gauge theory for finite-dimensional dynamical systems

    International Nuclear Information System (INIS)

    Gurfil, Pini

    2007-01-01

    Gauge theory is a well-established concept in quantum physics, electrodynamics, and cosmology. This concept has recently proliferated into new areas, such as mechanics and astrodynamics. In this paper, we discuss a few applications of gauge theory in finite-dimensional dynamical systems. We focus on the concept of rescriptive gauge symmetry, which is, in essence, rescaling of an independent variable. We show that a simple gauge transformation of multiple harmonic oscillators driven by chaotic processes can render an apparently ''disordered'' flow into a regular dynamical process, and that there exists a strong connection between gauge transformations and reduction theory of ordinary differential equations. Throughout the discussion, we demonstrate the main ideas by considering examples from diverse fields, including quantum mechanics, chemistry, rigid-body dynamics, and information theory

  10. Systemic Functional Theory: A Pickax of Textual Investigation

    Directory of Open Access Journals (Sweden)

    Taofeek Dalamu

    2017-03-01

    Full Text Available The study examines Systemic Functional Theory (SFT as a tool of examining text, and perhaps, text of any dimension as long as it falls within the grammatical organs of the clause. The author provides explanations for the theory from its relevant source(s. The chronological appreciation involves the efforts of Saussure, Firth, Malinowski, Hjelmslev, etc. However, Halliday’s insight seems prominent and upon which Systemic Functional Theory receives a global status that it has assumed today. Halliday constructs numerous concepts e.g. lexicogrammar, processes, cohesion, coherence, system, system network with background from traditional grammar and sociological tokens. In addition to that, the three metafunctions are characterized as its core operational concepts. Out of these, the mood system serves as the instrument of analysis of Psalm one utilized in this endeavor as a case study. Although the clauses fall within the profile of the indicative and imperative, the study reveals that some of the structures are inverted in order to propagate the intended messages. To that end, there are inverted indicative clauses expressed as inverted declarative statements, inverted imperative questions and inverted negativized polarity. In sum, Systemic Functional Theory is a facility for explaining different shapes of texts.

  11. The Einstein-Vlasov System/Kinetic Theory

    Directory of Open Access Journals (Sweden)

    Håkan Andréasson

    2002-12-01

    Full Text Available The main purpose of this article is to provide a guide to theorems on global properties of solutions to the Einstein-Vlasov system. This system couples Einstein's equations to a kinetic matter model. Kinetic theory has been an important field of research during several decades in which the main focus has been on nonrelativistic and special relativistic physics, i.e., to model the dynamics of neutral gases, plasmas, and Newtonian self-gravitating systems. In 1990, Rendall and Rein initiated a mathematical study of the Einstein-Vlasov system. Since then many theorems on global properties of solutions to this system have been established. The Vlasov equation describes matter phenomenologically, and it should be stressed that most of the theorems presented in this article are not presently known for other such matter models (i.e., fluid models. This paper gives introductions to kinetic theory in non-curved spacetimes and then the Einstein-Vlasov system is introduced. We believe that a good understanding of kinetic theory in non-curved spacetimes is fundamental to good comprehension of kinetic theory in general relativity.

  12. The Einstein-Vlasov System/Kinetic Theory

    Directory of Open Access Journals (Sweden)

    Andréasson Håkan

    2005-01-01

    Full Text Available The main purpose of this article is to provide a guide to theorems on global properties of solutions to the Einstein-Vlasov system. This system couples Einstein’s equations to a kinetic matter model. Kinetic theory has been an important field of research during several decades in which the main focus has been on nonrelativistic and special relativistic physics, i.e. to model the dynamics of neutral gases, plasmas, and Newtonian self-gravitating systems. In 1990, Rendall and Rein initiated a mathematical study of the Einstein-Vlasov system. Since then many theorems on global properties of solutions to this system have been established. The Vlasov equation describes matter phenomenologically, and it should be stressed that most of the theorems presented in this article are not presently known for other such matter models (i.e. fluid models. This paper gives introductions to kinetic theory in non-curved spacetimes and then the Einstein-Vlasov system is introduced. We believe that a good understanding of kinetic theory in non-curved spacetimes is fundamental to good comprehension of kinetic theory in general relativity.

  13. Lie theory and control systems defined on spheres

    Science.gov (United States)

    Brockett, R. W.

    1972-01-01

    It is shown that in constructing a theory for the most elementary class of control problems defined on spheres, some results from the Lie theory play a natural role. To understand controllability, optimal control, and certain properties of stochastic equations, Lie theoretic ideas are needed. The framework considered here is the most natural departure from the usual linear system/vector space problems which have dominated control systems literature. For this reason results are compared with those previously available for the finite dimensional vector space case.

  14. Network analysis and synthesis a modern systems theory approach

    CERN Document Server

    Anderson, Brian D O

    2006-01-01

    Geared toward upper-level undergraduates and graduate students, this book offers a comprehensive look at linear network analysis and synthesis. It explores state-space synthesis as well as analysis, employing modern systems theory to unite the classical concepts of network theory. The authors stress passive networks but include material on active networks. They avoid topology in dealing with analysis problems and discuss computational techniques. The concepts of controllability, observability, and degree are emphasized in reviewing the state-variable description of linear systems. Explorations

  15. Time delay systems theory, numerics, applications, and experiments

    CERN Document Server

    Ersal, Tulga; Orosz, Gábor

    2017-01-01

    This volume collects contributions related to selected presentations from the 12th IFAC Workshop on Time Delay Systems, Ann Arbor, June 28-30, 2015. The included papers present novel techniques and new results of delayed dynamical systems. The topical spectrum covers control theory, numerical analysis, engineering and biological applications as well as experiments and case studies. The target audience primarily comprises research experts in the field of time delay systems, but the book may also be beneficial for graduate students alike. .

  16. The Nature of Living Systems: An Exposition of the Basic Concepts in General Systems Theory.

    Science.gov (United States)

    Miller, James G.

    General systems theory is a set of related definitions, assumptions, and propositions which deal with reality as an integrated hierarchy of organizations of matter and energy. In this paper, the author defines the concepts of space, time, matter, energy, and information in terms of their meaning in general systems theory. He defines a system as a…

  17. Lectures on algebraic system theory: Linear systems over rings

    Science.gov (United States)

    Kamen, E. W.

    1978-01-01

    The presentation centers on four classes of systems that can be treated as linear systems over a ring. These are: (1) discrete-time systems over a ring of scalars such as the integers; (2) continuous-time systems containing time delays; (3) large-scale discrete-time systems; and (4) time-varying discrete-time systems.

  18. International Summer School on Mathematical Systems Theory and Economics

    CERN Document Server

    Szegö, G

    1969-01-01

    The International Summer School on Mathematical Systems Theory and Economics was held at the Villa Monastero in Varenna, Italy, from June 1 through June 12, 1967. The objective of this Summer School was to review the state of the art and the prospects for the application of the mathematical theory of systems to the study and the solution of economic problems. Particular emphasis was given to the use of the mathematical theory of control for the solution of problems in economics. It was felt that the publication of a volume collecting most of the lectures given at the school would show the current status of the application of these methods. The papers are organized into four sections arranged into two volumes: basic theories and optimal control of economic systems which appear in the first volume, and special mathematical problems and special applications which are contained in the second volume. Within each section the papers follow in alphabetical order by author. The seven papers on basic theories are a rat...

  19. Nonautonomous linear Hamiltonian systems oscillation, spectral theory and control

    CERN Document Server

    Johnson, Russell; Novo, Sylvia; Núñez, Carmen; Fabbri, Roberta

    2016-01-01

    This monograph contains an in-depth analysis of the dynamics given by a linear Hamiltonian system of general dimension with nonautonomous bounded and uniformly continuous coefficients, without other initial assumptions on time-recurrence. Particular attention is given to the oscillation properties of the solutions as well as to a spectral theory appropriate for such systems. The book contains extensions of results which are well known when the coefficients are autonomous or periodic, as well as in the nonautonomous two-dimensional case. However, a substantial part of the theory presented here is new even in those much simpler situations. The authors make systematic use of basic facts concerning Lagrange planes and symplectic matrices, and apply some fundamental methods of topological dynamics and ergodic theory. Among the tools used in the analysis, which include Lyapunov exponents, Weyl matrices, exponential dichotomy, and weak disconjugacy, a fundamental role is played by the rotation number for linear Hami...

  20. A Theory of the Origin of the Solar System

    Directory of Open Access Journals (Sweden)

    V. MITRA

    1969-06-01

    Full Text Available theory of tlie origin of the solar system is propounded.
    The approach belongs to the dualistic class of theories but still retains all
    the essential features of a monistic theory. It emphasizes the need of a
    foreign body approaching the solar nebula for the occurrence of an instability
    in the boundary layer of the nebular disc. This foreign body is postulated
    to be a brother star of the Sun in the sense that both belong to a common
    central parent body such as any two successive planets belong to
    the Sun. The analysis gives a law of distance of the planets from tlie Sun.
    This law is obeyed separately by both the groups of the planets more closely
    than the existing Titius - Bode's law. The law is also found to be applicable
    in the various satellite systems.

  1. System, subsystem, hive: boundary problems in computational theories of consciousness

    Directory of Open Access Journals (Sweden)

    Tomer Fekete

    2016-07-01

    Full Text Available A computational theory of consciousness should include a quantitative measure of consciousness, or MoC, that (i would reveal to what extent a given system is conscious, (ii would make it possible to compare not only different systems, but also the same system at different times, and (iii would be graded, because so is consciousness. However, unless its design is properly constrained, such an MoC gives rise to what we call the boundary problem: an MoC that labels a system as conscious will do so for some – perhaps most – of its subsystems, as well as for irrelevantly extended systems (e.g., the original system augmented with physical appendages that contribute nothing to the properties supposedly supporting consciousness, and for aggregates of individually conscious systems (e.g., groups of people. This problem suggests that the properties that are being measured are epiphenomenal to consciousness, or else it implies a bizarre proliferation of minds. We propose that a solution to the boundary problem can be found by identifying properties that are intrinsic or systemic: properties that clearly differentiate between systems whose existence is a matter of fact, as opposed to those whose existence is a matter of interpretation (in the eye of the beholder. We argue that if a putative MoC can be shown to be systemic, this ipso facto resolves any associated boundary issues. As test cases, we analyze two recent theories of consciousness in light of our definitions: the Integrated Information Theory and the Geometric Theory of consciousness.

  2. Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta

    Directory of Open Access Journals (Sweden)

    V. V. Hryhorovskyi

    2015-04-01

    Full Text Available Actuality. The correlation analysis between various indices of bone tissue condition was not previously carried out in patients with osteogenesis imperfecta. Aim. On purpose to determine differences and index correlations before and after intake of pamidronate systemic therapy in 13 patients with osteogenesis imperfecta indices of some methods including histomorphometric were studied. Results. We found correlation parametres of biochemical indices, on one side and histomorphometric – on the other. Conclusion. After systemic therapy mean parametres of «bone volume» in iliobiopsies increase, and «osteoid surface» and «osteoclast index per surface unit» in patients with osteogenesis imperfecta of I type – decrease, that one can regard as a tendency to improvement of the bone tissue structural-functional condition.

  3. Communication and Language in Niklas Luhmann's Systems-Theory

    Directory of Open Access Journals (Sweden)

    Kathrin Maurer

    2010-01-01

    Full Text Available This article investigates the function and reality of language in Niklas Luhmann's systems theory. How can one interpret the systems-theoretical assumption that language is based on communication? Luhmann describes language as a dynamic media/form relationship, which is able to couple the social and psychological system. This structural coupling, which constructs consciousness and language as two autonomous systems, raises problems if one defines language from a cognitive point of view. This article discusses these problems and aims to develop assumptions and questions within the systems-theoretical approach.

  4. The Genetic Determinism of Biochemical Systems Polymorphous From the Blood Serum in Pigs

    Directory of Open Access Journals (Sweden)

    Nicoleta Işfan

    2010-05-01

    Full Text Available The study of genetic markers and identification of new markers make the subject of an increasing number of research projects in various fields such as genetics of immunology, biochemical genetics, molecular genetics, quantitative genetics and the genetic amelioration of animals. The information provided by electrophoresis graphs has been used to determine the frequency of various categories of alleles (for the loci of pre-albumin, transferines and serum amylases, the frequency of various phenotypes and the genetic structure for each and every locus and, simultaneously, for the loci being studied. The discussion over the varieties of serum proteins was carried on for the purpose of using them as genetic markers, in order to appreciate the levels of genetic unity or diversity within the stock of swine that has been studied. A pair of simple alleles has been determined for each of the three loci. When the three loci were studied simultaneously, out of the 27 possible combinations, only 15 have been found. The sample studied has found to be genetically balanced for every of the three loci. However, when the simultaneous study has been applied, the same sample has not been found genetically balanced.

  5. The biochemical characterization of two phosphate transport systems in Phytomonas serpens.

    Science.gov (United States)

    Vieira-Bernardo, Rodrigo; Gomes-Vieira, André Luiz; Carvalho-Kelly, Luiz Fernando; Russo-Abrahão, Thais; Meyer-Fernandes, José Roberto

    2017-02-01

    Inorganic phosphate (P i ) is an essential nutrient for all organisms because it is required for a variety of biochemical processes, such as signal transduction and the synthesis of phosphate-containing biomolecules. Assays of 32 P i uptake performed in the absence or in the presence of Na + indicated the existence of a Na + -dependent and a Na + -independent P i transporter in Phytomonas serpens. Phylogenetic analysis of two hypothetical protein sequences of Phytomonas (EM1) showed similarities to the high-affinity P i transporters of Saccharomyces cerevisiae: Pho84, a Na + -independent P i transporter, and Pho89, a Na + -dependent P i transporter. Plasma membrane depolarization by FCCP, an H + ionophore, strongly decreased P i uptake via both Na + -independent and Na + -dependent carriers, indicating that a membrane potential is essential for P i influx. In addition, the furosemide-sensitive Na + -pump activity in the cells grown in low P i conditions was found to be higher than the activity detected in the plasma membrane of cells cultivated at high P i concentration, suggesting that the up-regulation of the Na + -ATPase pump could be related to the increase of P i uptake by the Pho89p Na + :P i symporter. Here we characterize for the first time two inorganic phosphate transporters powered by Na + and H + gradients and activated by low P i availability in the phytopathogen P. serpens. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Ecological theories of systems and contextual change in medical education.

    Science.gov (United States)

    Ellaway, Rachel H; Bates, Joanna; Teunissen, Pim W

    2017-12-01

    Contemporary medical practice is subject to many kinds of change, to which both individuals and systems have to respond and adapt. Many medical education programmes have their learners rotating through different training contexts, which means that they too must learn to adapt to contextual change. Contextual change presents many challenges to medical education scholars and practitioners, not least because of a somewhat fractured and contested theoretical basis for responding to these challenges. There is a need for robust concepts to articulate and connect the various debates on contextual change in medical education. Ecological theories of systems encompass a range of concepts of how and why systems change and how and why they respond to change. The use of these concepts has the potential to help medical education scholars explore the nature of change and understand the role it plays in affording as well as limiting teaching and learning. This paper, aimed at health professional education scholars and policy makers, explores a number of key concepts from ecological theories of systems to present a comprehensive model of contextual change in medical education to inform theory and practice in all areas of medical education. The paper considers a range of concepts drawn from ecological theories of systems, including biotic and abiotic factors, panarchy, attractors and repellers, basins of attraction, homeostasis, resilience, adaptability, transformability and hysteresis. Each concept is grounded in practical examples from medical education. Ecological theories of systems consider change and response in terms of adaptive cycles functioning at different scales and speeds. This can afford opportunities for systematic consideration of responses to contextual change in medical education, which in turn can inform the design of education programmes, activities, evaluations, assessments and research that accommodates the dynamics and consequences of contextual change.

  7. The Formation of the Solar System: Theories Old and New

    Science.gov (United States)

    Woolfson, Michael

    ch. 1. Theories come and theories go -- ch. 2. Measuring atoms and the universe -- ch. 3. Greek offerings -- ch. 4. The shoulders of giants -- ch. 5. A voyage of discovery to the solar system -- ch. 6. The problem to be solved -- ch. 7. The French connection -- ch. 8. American Catherine-Wheels -- ch. 9. British big tides -- ch. 10. Russian could capture-with British help -- ch. 11. German vortices-with a little French help -- ch. 12. McCrea's floccules -- ch. 13. What earlier theories indicate -- ch. 14. Disks around new stars -- ch. 15. Planets around other stars -- ch. 16. Disks around older stars -- ch. 17. What a theory should explain now -- ch. 18. The new Solar Nebula theory: the angular momentum problem -- ch. 19. Making planets top-down -- ch. 20. A bottom-up alternative -- ch. 21. Making planets faster -- ch. 22. Wandering planets -- ch. 23. Back to top-down -- ch. 24. This is the stuff that stars are made of -- ch. 25. Making dense cool clouds -- ch. 26. A star is born -- ch. 27. Close to the maddening crowd -- ch. 28. Close encounters of the stellar kind -- ch. 29. Ever decreasing circles -- ch. 30. How many planetary systems? -- ch. 31. Starting a family -- ch. 32. Tilting-but not as windmills -- ch. 33. The terrestrial planets raise problems! -- ch. 34. A British Bang theory: the earth and Venus -- ch. 35. Behold the wandering moon -- ch. 36. Fleet Mercury and warlike Mars -- ch. 37. Gods of the sea and the nether regions -- ch. 38. Bits and pieces -- ch. 39. Comets-the harbingers of doom! -- ch. 40. Making atoms with a biggish bang -- ch. 41. Is the capture theory valid?

  8. A Postcolonial Perspective on the Systemic Theory of Gifted Education

    Science.gov (United States)

    Christie, Michael

    2012-01-01

    A systemic theory of gifted education, and in particular the notion of the actiotope receives surprising support from an epistemology until recently largely unrecognized and undervalued--that of Australian Aborigines. As part of an ongoing transdisciplinary collaborative research practice, a group Yolngu (north east Arnhem Land Aboriginal) elders…

  9. Distribution system reliability evaluation using credibility theory | Xu ...

    African Journals Online (AJOL)

    This paper describes a new method of using credibility theory to evaluate distribution system reliability. The advantage of this method lies in its ability to account for both objective and subjective uncertainty by integrating stochastic and fuzzy approaches. Equipment failures are modeled as random events, while the ...

  10. A Dynamic Systems Theory Model of Visual Perception Development

    Science.gov (United States)

    Coté, Carol A.

    2015-01-01

    This article presents a model for understanding the development of visual perception from a dynamic systems theory perspective. It contrasts to a hierarchical or reductionist model that is often found in the occupational therapy literature. In this proposed model vision and ocular motor abilities are not foundational to perception, they are seen…

  11. Applications of Bayesian decision theory to intelligent tutoring systems

    NARCIS (Netherlands)

    Vos, Hendrik J.

    1994-01-01

    Some applications of Bayesian decision theory to intelligent tutoring systems are considered. How the problem of adapting the appropriate amount of instruction to the changing nature of a student's capabilities during the learning process can be situated in the general framework of Bayesian decision

  12. Random matrix theory for pseudo-Hermitian systems: Cyclic blocks

    Indian Academy of Sciences (India)

    We discuss the relevance of random matrix theory for pseudo-Hermitian systems, and, for Hamiltonians that break parity and time-reversal invariance . In an attempt to understand the random Ising model, we present the treatment of cyclic asymmetric matrices with blocks and show that the nearest-neighbour spacing ...

  13. An Application of General System Theory (GST) to Group Therapy.

    Science.gov (United States)

    Matthews, Charles O.

    1992-01-01

    Demonstrates the compatibility of General System Theory (GST) with the traditional counseling literature in explicating a therapy group's progression through Tuckman's (1965, 1977) developmental stages (forming, storming, norming, performing, and adjourning). Description uses both traditional group literature and GST concepts. (Author/NB)

  14. Solution of quantum integrable systems from quiver gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Dorey, Nick [Department of Applied Mathematics and Theoretical Physics, University of Cambridge,Cambridge (United Kingdom); Zhao, Peng [Simons Center for Geometry and Physics, Stony Brook University,Stony Brook (United States)

    2017-02-23

    We construct new integrable systems describing particles with internal spin from four-dimensional N = 2 quiver gauge theories. The models can be quantized and solved exactly using the quantum inverse scattering method and also using the Bethe/Gauge correspondence.

  15. Complex Time-Delay Systems Theory and Applications

    CERN Document Server

    Atay, Fatihcan M

    2010-01-01

    Time delays in dynamical systems arise as an inevitable consequence of finite speeds of information transmission. Realistic models increasingly demand the inclusion of delays in order to properly understand, analyze, design, and control real-life systems. The goal of this book is to present the state-of-the-art in research on time-delay dynamics in the framework of complex systems and networks. While the mathematical theory of delay equations is quite mature, its application to the particular problems of complex systems and complexity is a newly emerging field, and the present volume aims to play a pioneering role in this perspective. The chapters in this volume are authored by renowned experts and cover both theory and applications in a wide range of fields, with examples extending from neuroscience and biology to laser physics and vehicle traffic. Furthermore, all chapters include sufficient introductory material and extensive bibliographies, making the book a self-contained reference for both students and ...

  16. Theory of heavy-fermion compounds theory of strongly correlated Fermi-systems

    CERN Document Server

    Amusia, Miron Ya; Shaginyan, Vasily R; Stephanovich, Vladimir A

    2015-01-01

    This book explains modern and interesting physics in heavy-fermion (HF) compounds to graduate students and researchers in condensed matter physics. It presents a theory of heavy-fermion (HF) compounds such as HF metals, quantum spin liquids, quasicrystals and two-dimensional Fermi systems. The basic low-temperature properties and the scaling behavior of the compounds are described within the framework of the theory of fermion condensation quantum phase transition (FCQPT). Upon reading the book, the reader finds that HF compounds with quite different microscopic nature exhibit the same non-Fermi liquid behavior, while the data collected on very different HF systems have a universal scaling behavior, and these compounds are unexpectedly uniform despite their diversity. For the reader's convenience, the analysis of compounds is carried out in the context of salient experimental results. The numerous calculations of the non-Fermi liquid behavior, thermodynamic, relaxation and transport properties, being in good...

  17. International Conference on Dynamical Systems : Theory and Applications

    CERN Document Server

    2016-01-01

    The book is a collection of contributions devoted to analytical, numerical and experimental techniques of dynamical systems, presented at the international conference "Dynamical Systems: Theory and Applications," held in Lódz, Poland on December 7-10, 2015. The studies give deep insight into new perspectives in analysis, simulation, and optimization of dynamical systems, emphasizing directions for future research. Broadly outlined topics covered include: bifurcation and chaos in dynamical systems, asymptotic methods in nonlinear dynamics, dynamics in life sciences and bioengineering, original numerical methods of vibration analysis, control in dynamical systems, stability of dynamical systems, vibrations of lumped and continuous sytems, non-smooth systems, engineering systems and differential equations, mathematical approaches to dynamical systems, and mechatronics.

  18. International Conference on Dynamical Systems : Theory and Applications

    CERN Document Server

    2016-01-01

    The book is the second volume of a collection of contributions devoted to analytical, numerical and experimental techniques of dynamical systems, presented at the international conference "Dynamical Systems: Theory and Applications," held in Lódz, Poland on December 7-10, 2015. The studies give deep insight into new perspectives in analysis, simulation, and optimization of dynamical systems, emphasizing directions for future research. Broadly outlined topics covered include: bifurcation and chaos in dynamical systems, asymptotic methods in nonlinear dynamics, dynamics in life sciences and bioengineering, original numerical methods of vibration analysis, control in dynamical systems, stability of dynamical systems, vibrations of lumped and continuous sytems, non-smooth systems, engineering systems and differential equations, mathematical approaches to dynamical systems, and mechatronics.

  19. Fast stochastic simulation of biochemical reaction systems by alternative formulations of the chemical Langevin equation

    KAUST Repository

    Mélykúti, Bence

    2010-01-01

    The Chemical Langevin Equation (CLE), which is a stochastic differential equation driven by a multidimensional Wiener process, acts as a bridge between the discrete stochastic simulation algorithm and the deterministic reaction rate equation when simulating (bio)chemical kinetics. The CLE model is valid in the regime where molecular populations are abundant enough to assume their concentrations change continuously, but stochastic fluctuations still play a major role. The contribution of this work is that we observe and explore that the CLE is not a single equation, but a parametric family of equations, all of which give the same finite-dimensional distribution of the variables. On the theoretical side, we prove that as many Wiener processes are sufficient to formulate the CLE as there are independent variables in the equation, which is just the rank of the stoichiometric matrix. On the practical side, we show that in the case where there are m1 pairs of reversible reactions and m2 irreversible reactions there is another, simple formulation of the CLE with only m1 + m2 Wiener processes, whereas the standard approach uses 2 m1 + m2. We demonstrate that there are considerable computational savings when using this latter formulation. Such transformations of the CLE do not cause a loss of accuracy and are therefore distinct from model reduction techniques. We illustrate our findings by considering alternative formulations of the CLE for a human ether a-go-go related gene ion channel model and the Goldbeter-Koshland switch. © 2010 American Institute of Physics.

  20. Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms

    Directory of Open Access Journals (Sweden)

    Sudesh Vasdev

    2006-09-01

    Full Text Available Sudesh Vasdev1, Vicki Gill1, Pawan K Singal21Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada; 2Institute of Cardiovascular Sciences, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, CanadaAbstract: Low ethanol intake is known to have a beneficial effect on cardiovascular disease. In cardiovascular disease, insulin resistance leads to altered glucose and lipid metabolism resulting in an increased production of aldehydes, including methylglyoxal. Aldehydes react non-enzymatically with sulfhydryl and amino groups of proteins forming advanced glycation end products (AGEs, altering protein structure and function. These alterations cause endothelial dysfunction with increased cytosolic free calcium, peripheral vascular resistance, and blood pressure. AGEs produce atherogenic effects including oxidative stress, platelet adhesion, inflammation, smooth muscle cell proliferation and modification of lipoproteins. Low ethanol intake attenuates hypertension and atherosclerosis but the mechanism of this effect is not clear. Ethanol at low concentrations is metabolized by low Km alcohol dehydrogenase and aldehyde dehydrogenase, both reactions resulting in the production of reduced nicotinamide adenine dinucleotide (NADH. This creates a reductive environment, decreasing oxidative stress and secondary production of aldehydes through lipid peroxidation. NADH may also increase the tissue levels of the antioxidants cysteine and glutathione, which bind aldehydes and stimulate methylglyoxal catabolism. Low ethanol improves insulin resistance, increases high-density lipoprotein and stimulates activity of the antioxidant enzyme, paraoxonase. In conclusion, we suggest that chronic low ethanol intake confers its beneficial effect mainly through its ability to increase antioxidant capacity and lower AGEs.Keywords: low ethanol, hypertension, cardiovascular disease, biochemical

  1. Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms

    Directory of Open Access Journals (Sweden)

    Sudesh Vasdev

    2006-05-01

    Full Text Available Sudesh Vasdev1, Vicki Gill1, Pawan K Singal21Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada; 2Institute of Cardiovascular Sciences, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, CanadaAbstract: Low ethanol intake is known to have a beneficial effect on cardiovascular disease. In cardiovascular disease, insulin resistance leads to altered glucose and lipid metabolism resulting in an increased production of aldehydes, including methylglyoxal. Aldehydes react non-enzymatically with sulfhydryl and amino groups of proteins forming advanced glycation end products (AGEs, altering protein structure and function. These alterations cause endothelial dysfunction with increased cytosolic free calcium, peripheral vascular resistance, and blood pressure. AGEs produce atherogenic effects including oxidative stress, platelet adhesion, inflammation, smooth muscle cell proliferation and modification of lipoproteins. Low ethanol intake attenuates hypertension and atherosclerosis but the mechanism of this effect is not clear. Ethanol at low concentrations is metabolized by low Km alcohol dehydrogenase and aldehyde dehydrogenase, both reactions resulting in the production of reduced nicotinamide adenine dinucleotide (NADH. This creates a reductive environment, decreasing oxidative stress and secondary production of aldehydes through lipid peroxidation. NADH may also increase the tissue levels of the antioxidants cysteine and glutathione, which bind aldehydes and stimulate methylglyoxal catabolism. Low ethanol improves insulin resistance, increases high-density lipoprotein and stimulates activity of the antioxidant enzyme, paraoxonase. In conclusion, we suggest that chronic low ethanol intake confers its beneficial effect mainly through its ability to increase antioxidant capacity and lower AGEs.Keywords: low ethanol, hypertension, cardiovascular disease, biochemical

  2. Yang-Baxter algebra - Integrable systems - Conformal quantum field theories

    International Nuclear Information System (INIS)

    Karowski, M.

    1989-01-01

    This series of lectures is based on investigations [1,2] of finite-size corrections for the six-vertex model by means of Bethe ansatz methods. In addition a review on applications of Yang-Baxter algebras and an introduction to the theory of integrable systems and the algebraic Bethe ansatz is presented. A Θ-vacuum like angle appearing in the RSOS-models is discussed. The continuum limit in the critical case of these statistical models is performed to obtain the minimal models of conformal quantum field theory. (author)

  3. Elements of a compatible optimization theory for coupled systems

    International Nuclear Information System (INIS)

    Bonnemay, A.

    1969-01-01

    The first theory deals with the compatible optimization in coupled systems. A game theory for two players and with a non-zero sum is first developed. The conclusions are then extended to the case of a game with any finite number of players. After this essentially static study, the dynamic aspect of the problem is applied to the case of games which evolve. By applying PONTRYAGIN maximum principle it is possible to derive a compatible optimisation theorem which constitutes a necessary condition. (author) [fr

  4. Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system.

    Science.gov (United States)

    Ge, Hao; Qian, Hong

    2009-10-02

    We show that the thermodynamic limit of a bistable phosphorylation-dephosphorylation cycle has a selection rule for the "more stable" macroscopic steady state. The analysis is akin to the Maxwell construction. Based on the chemical master equation approach, it is shown that, except at a critical point, bistability disappears in the stochastic model when fluctuation is sufficiently low but unneglectable. Onsager's Gaussian fluctuation theory applies to the unique macroscopic steady state. With an initial state in the basin of attraction of the "less stable" steady state, the deterministic dynamics obtained by the law of mass action is a metastable phenomenon. Stability and robustness in cell biology are emergent stochastic concepts.

  5. Linear circuits, systems and signal processing: theory and application

    International Nuclear Information System (INIS)

    Byrnes, C.I.; Saeks, R.E.; Martin, C.F.

    1988-01-01

    In part because of its universal role as a first approximation of more complicated behaviour and in part because of the depth and breadth of its principle paradigms, the study of linear systems continues to play a central role in control theory and its applications. Enhancing more traditional applications to aerospace and electronics, application areas such as econometrics, finance, and speech and signal processing have contributed to a renaissance in areas such as realization theory and classical automatic feedback control. Thus, the last few years have witnessed a remarkable research effort expended in understanding both new algorithms and new paradigms for modeling and realization of linear processes and in the analysis and design of robust control strategies. The papers in this volume reflect these trends in both the theory and applications of linear systems and were selected from the invited and contributed papers presented at the 8th International Symposium on the Mathematical Theory of Networks and Systems held in Phoenix on June 15-19, 1987

  6. Theory of linear physical systems theory of physical systems from the viewpoint of classical dynamics, including Fourier methods

    CERN Document Server

    Guillemin, Ernst A

    2013-01-01

    An eminent electrical engineer and authority on linear system theory presents this advanced treatise, which approaches the subject from the viewpoint of classical dynamics and covers Fourier methods. This volume will assist upper-level undergraduates and graduate students in moving from introductory courses toward an understanding of advanced network synthesis. 1963 edition.

  7. Comparison of measured concentration values of biochemical serum markers with two immunoassay systems in first trimester screening for fetal aneuploidy.

    Science.gov (United States)

    Hörmansdörfer, Cindy; Soergel, Philipp; Hillemanns, Peter; Schmidt, Peter

    2012-02-01

    Non-invasive first trimester screening for fetal aneuploidy is based on the consideration of fetal nuchal translucency, biochemical serum markers 'pregnancy associated plasma protein A' (PAPP-A), and 'free beta-humane chorionic gonadotropin' (fβ-hCG). The blood sera of 168 pregnant women in 11 + 0 to 13 + 6 weeks of gestation were examined by both the COBAS (Roche Holding GmbH, Germany) and KRYPTOR (Brahms GmbH, Germany) immunoassay systems in two quality controlled laboratories. The concentration values were converted into multiple of median (MoM) values and compared through a two-tailed t test. The concentration values of PAPP-A differed significantly from each other (p pregnancy outcomes.

  8. Energy flow theory of nonlinear dynamical systems with applications

    CERN Document Server

    Xing, Jing Tang

    2015-01-01

    This monograph develops a generalised energy flow theory to investigate non-linear dynamical systems governed by ordinary differential equations in phase space and often met in various science and engineering fields. Important nonlinear phenomena such as, stabilities, periodical orbits, bifurcations and chaos are tack-led and the corresponding energy flow behaviors are revealed using the proposed energy flow approach. As examples, the common interested nonlinear dynamical systems, such as, Duffing’s oscillator, Van der Pol’s equation, Lorenz attractor, Rössler one and SD oscillator, etc, are discussed. This monograph lights a new energy flow research direction for nonlinear dynamics. A generalised Matlab code with User Manuel is provided for readers to conduct the energy flow analysis of their nonlinear dynamical systems. Throughout the monograph the author continuously returns to some examples in each chapter to illustrate the applications of the discussed theory and approaches. The book can be used as ...

  9. Mode 3 knowledge production: Systems and systems theory, clusters and networks

    OpenAIRE

    Carayannis, Elias G.; Campbell, David F. J.; Rehman, Scheherazade S.

    2016-01-01

    With the comprehensive term of "Mode 3," we want to draw a conceptual link between systems and systems theory and want to demonstrate further how this can be applied to knowledge in the next steps. Systems can be understood as being composed of "elements", which are tied together by a "self-rationale". For innovation, often innovation clusters and innovation networks are being regarded as important. By leveraging systems theory for innovation concepts, one can implement references between the...

  10. Effects of Antifouling Biocides on Molecular and Biochemical Defense System in the Gill of the Pacific Oyster Crassostrea gigas

    Science.gov (United States)

    Park, Mi Seon; Kim, Young Dae; Kim, Bo-Mi; Kim, Youn-Jung; Kim, Jang Kyun; Rhee, Jae-Sung

    2016-01-01

    Antifouling biocides such as organotin compounds and their alternatives are potent toxicants in marine ecosystems. In this study, we employed several molecular and biochemical response systems of the Pacific oyster Crassostrea gigas to understand a potential mode of action of antifouling biocides (i.e. tributyltin (TBT), diuron and irgarol) after exposure to different concentrations (0.01, 0.1, and 1 μg L-1) for 96 h. As a result, all the three antifouling biocides strongly induced the antioxidant defense system. TBT reduced both enzymatic activity and mRNA expression of Na+/K+-ATPase and acetylcholinesterase (AChE). Lower levels of both Na+/K+-ATPase activity and AChE mRNA expression were observed in the diuron-exposed oysters compared to the control, while the irgarol treatment reduced only the transcriptional expression of AChE gene. We also analyzed transcript profile of heat shock protein (Hsp) superfamily in same experimental conditions. All antifouling biocides tested in this study significantly modulated mRNA expression of Hsp superfamily with strong induction of Hsp70 family. Taken together, overall results indicate that representative organotin TBT and alternatives have potential hazardous effects on the gill of C. gigas within relatively short time period. Our results also suggest that analyzing a series of molecular and biochemical parameters can be a way of understanding and uncovering the mode of action of emerging antifouling biocides. In particular, it was revealed that Pacific oysters have different sensitivities depend on the antifouling biocides. PMID:28006823

  11. Vladimir Lefebvre's Theory of Two Systems of Ethical Cognition

    Directory of Open Access Journals (Sweden)

    Stuart A. Umpleby

    2016-10-01

    Full Text Available In his 1982 book Algebra of Conscience Vladimir Lefebvre contended that the dominant ethical systems in the West and the Soviet Union were fundamentally different [1]. However, people on each side usually assume that there is only one type of ethical reasoning. The result is that each side takes actions that are misunderstood by the other side. With the guidance of Lefebvre's theory it became possible for both sides to take actions which, although counterintuitive in their own thinking, could lead to more success in negotiations and a reduction in armaments. Luckily, Lefebvre's theory was used at the highest levels of the governments of the US and the Soviet Union during the break-up of the Soviet Union. Lefebvre's theory can be used in negotiations between governments, between businesses, and between individuals. The theory explains some of the difficulties encountered in the transitions in the post-communist countries. It may also prove helpful in negotiating with extremist groups. [1] V. Lefebvre, Algebra of Conscience: A Comparative Analysis of Western and Soviet Ethical Systems, With a forword by Anatol Rapoport, Dordrecht, Holland: D. Reidel Publishing, 1982.

  12. Realistic theory of electronic correlations in nanoscopic systems

    Science.gov (United States)

    Schüler, Malte; Barthel, Stefan; Wehling, Tim; Karolak, Michael; Valli, Angelo; Sangiovanni, Giorgio

    2017-07-01

    Nanostructures with open shell transition metal or molecular constituents host often strong electronic correlations and are highly sensitive to atomistic material details. This tutorial review discusses method developments and applications of theoretical approaches for the realistic description of the electronic and magnetic properties of nanostructures with correlated electrons. First, the implementation of a flexible interface between density functional theory and a variant of dynamical mean field theory (DMFT) highly suitable for the simulation of complex correlated structures is explained and illustrated. On the DMFT side, this interface is largely based on recent developments of quantum Monte Carlo and exact diagonalization techniques allowing for efficient descriptions of general four fermion Coulomb interactions, reduced symmetries and spin-orbit coupling, which are explained here. With the examples of the Cr (001) surfaces, magnetic adatoms, and molecular systems it is shown how the interplay of Hubbard U and Hund's J determines charge and spin fluctuations and how these interactions drive different sorts of correlation effects in nanosystems. Non-local interactions and correlations present a particular challenge for the theory of low dimensional systems. We present our method developments addressing these two challenges, i.e., advancements of the dynamical vertex approximation and a combination of the constrained random phase approximation with continuum medium theories. We demonstrate how non-local interaction and correlation phenomena are controlled not only by dimensionality but also by coupling to the environment which is typically important for determining the physics of nanosystems.

  13. Theory of constraints for publicly funded health systems.

    Science.gov (United States)

    Sadat, Somayeh; Carter, Michael W; Golden, Brian

    2013-03-01

    Originally developed in the context of publicly traded for-profit companies, theory of constraints (TOC) improves system performance through leveraging the constraint(s). While the theory seems to be a natural fit for resource-constrained publicly funded health systems, there is a lack of literature addressing the modifications required to adopt TOC and define the goal and performance measures. This paper develops a system dynamics representation of the classical TOC's system-wide goal and performance measures for publicly traded for-profit companies, which forms the basis for developing a similar model for publicly funded health systems. The model is then expanded to include some of the factors that affect system performance, providing a framework to apply TOC's process of ongoing improvement in publicly funded health systems. Future research is required to more accurately define the factors affecting system performance and populate the model with evidence-based estimates for various parameters in order to use the model to guide TOC's process of ongoing improvement.

  14. Theory and simulation of strong correlations in quantum Coulomb systems

    Science.gov (United States)

    Bonitz, M.; Semkat, D.; Filinov, A.; Golubnychyi, V.; Kremp, D.; Gericke, D. O.; Murillo, M. S.; Filinov, V.; Fortov, V.; Hoyer, W.; Koch, S. W.

    2003-06-01

    Strong correlations in quantum Coulomb systems (QCS) are attracting increasing interest in many fields ranging from dense plasmas and semiconductors to metal clusters and ultracold trapped ions. Examples are bound states in dense plasmas (atoms, molecules, clusters) and semiconductors (excitons, trions, biexcitons) or Coulomb crystals. We present first-principle simulation results of these systems including path integral Monte Carlo simulations of the equilibrium behaviour of dense hydrogen and electron-hole plasmas and molecular dynamics and quantum kinetic theory simulations of the nonequilibrium properties of QCS. Finally, we critically assess potential and limitations of the various methods in their application to Coulomb systems.

  15. The theory and practice of the Dewey Decimal Classification system

    CERN Document Server

    Satija, M P

    2013-01-01

    The Dewey Decimal Classification system (DDC) is the world's most popular library classification system. The 23rd edition of the DDC was published in 2011. This second edition of The Theory and Practice of the Dewey Decimal Classification System examines the history, management and technical aspects of the DDC up to its latest edition. The book places emphasis on explaining the structure and number building techniques in the DDC and reviews all aspects of subject analysis and number building by the most recent version of the DDC. A history of, and introduction to, the DDC is followed by subjec

  16. Transition Theory – Sustainable Transition of Socio-Technical Systems

    DEFF Research Database (Denmark)

    Søndergård, Bent; Holm, Jesper; Stauning, Inger

    2015-01-01

    Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction......Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction...

  17. Affordances in activity theory and cognitive systems engineering

    DEFF Research Database (Denmark)

    Albrechtsen, H.; Andersen, H.H.K.; Bødker, S.

    2001-01-01

    is supplemented by careful analyses of other human modalities and activities than visual perception. Within HMI two well established perspectives on HMI,Activity Theory (AT) and Cognitive Systems Engineering (CSE), have discussed such analyses and design of action possibilities focusing on providing computer...... in purposeful activity. AT and CSE follow the original notion by Gibson on the actor's dynamic shifting between foreground and background of the environment. Furthermore, their work- and actor-centred approach to analysis and designof information systems opens up to an extension of Gibson's original ideas...... on design for low level interaction modalities. To incorporate the concept of affordances in the design of human computer interaction it is necessary to systematically unravel affordances that supporthuman action possibilities. Furthermore, it is a necessity that Gibson's theory of affordances...

  18. Perturbation theory calculations of model pair potential systems

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Jianwu [Iowa State Univ., Ames, IA (United States)

    2016-01-01

    Helmholtz free energy is one of the most important thermodynamic properties for condensed matter systems. It is closely related to other thermodynamic properties such as chemical potential and compressibility. It is also the starting point for studies of interfacial properties and phase coexistence if free energies of different phases can be obtained. In this thesis, we will use an approach based on the Weeks-Chandler-Anderson (WCA) perturbation theory to calculate the free energy of both solid and liquid phases of Lennard-Jones pair potential systems and the free energy of liquid states of Yukawa pair potentials. Our results indicate that the perturbation theory provides an accurate approach to the free energy calculations of liquid and solid phases based upon comparisons with results from molecular dynamics (MD) and Monte Carlo (MC) simulations.

  19. A Systematic Review of Literature Using Business Systems Theory

    DEFF Research Database (Denmark)

    Rana, Mohammad Bakhtiar; Morgan, Glenn

    2015-01-01

    Business system theory (BST) lies at the intersection of organization theory, political economy and sociology. It is gaining incremental attention in the field of management, particularly in cross-border and comparative studies of the structure, strategy and management of multinationals. Yet......, international business (IB) studies do not tend to borrow much from this sub-field. This paper reviews BST literature from 1992 to 2015 and seeks to identify its contributions and gaps, in ways that can be helpful for future research in IB. Trend analysis of BST literature and mapping this sub-field suggests...... that the BST research stream can be identified in relation to four ‘broad themes’ which we describe as junctures- i.e. comparative business systems, internationalisation and MNC management, organizational capability and innovation, and transnational communities. Mapping and pattern recognition of the ‘themes...

  20. Continuous and distributed systems II theory and applications

    CERN Document Server

    Zgurovsky, Mikhail

    2015-01-01

    As in the previous volume on the topic, the authors close the gap between abstract mathematical approaches, such as applied methods of modern algebra and analysis, fundamental and computational mechanics, nonautonomous and stochastic dynamical systems, on the one hand, and practical applications in nonlinear mechanics, optimization, decision making theory and control theory on the other. Readers will also benefit from the presentation of modern mathematical modeling methods for the numerical solution of complicated engineering problems in biochemistry, geophysics, biology and climatology. This compilation will be of interest to mathematicians and engineers working at the interface of these fields. It presents selected works of the joint seminar series of Lomonosov Moscow State University and the Institute for Applied System Analysis at National Technical University of Ukraine “Kyiv Polytechnic Institute”. The authors come from Brazil, Germany, France, Mexico, Spain, Poland, Russia, Ukraine, and the USA. ...

  1. Information theory and stochastics for multiscale nonlinear systems

    CERN Document Server

    Majda, Andrew J; Grote, Marcus J

    2005-01-01

    This book introduces mathematicians to the fascinating emerging mathematical interplay between ideas from stochastics and information theory and important practical issues in studying complex multiscale nonlinear systems. It emphasizes the serendipity between modern applied mathematics and applications where rigorous analysis, the development of qualitative and/or asymptotic models, and numerical modeling all interact to explain complex phenomena. After a brief introduction to the emerging issues in multiscale modeling, the book has three main chapters. The first chapter is an introduction to information theory with novel applications to statistical mechanics, predictability, and Jupiter's Red Spot for geophysical flows. The second chapter discusses new mathematical issues regarding fluctuation-dissipation theorems for complex nonlinear systems including information flow, various approximations, and illustrates applications to various mathematical models. The third chapter discusses stochastic modeling of com...

  2. Effect of humic-plant feed preparations on biochemical blood parameters of laying hens in deep litter housing system.

    Science.gov (United States)

    Bubel, F; Dobrzański, Z; Gaweł, A; Pogoda-Sewerniak, K; Grela, E R

    2015-01-01

    An influence of various humic-plant feed additives based on some herbs (nettle, chamomile, yarrow, perforatum), lucerne and humic materials on biochemical indices of Lohmann Brown (LB) layers blood plasma was estimated. Hens were housed in deep litter system, 20 birds in a group. Four groups were formed: control (C - standard feeding), and experimental, supplemented with prepara- tions: E-1 herbal-humic, E-2 humic-herbal and E-3--humic-lucerne. Hens were placed in the pens on the 16th week of life, addition of preparations with standard food mixture started at the 22nd wk and lasted until 66th wk of life. Blood for analyses was collected four times in the following periods: 27, 37, 54 and 65th wk of life. The applied humic-plant preparations to a limited degree affected the values of examined biochemical parameters in serum: total protein (TP), albumins (Albs), glucose (Glu), urea, triacylglycerols (TAG), total cholesterol (TCh), alanine aminotransferase (ALT), aspartate aminot- ransferase (AST) and alkaline phosphatase (ALP). It is difficult to determine based on these study, which preparation is one the most active biologically, however is seems that humic-lucerne prepara- tion affected the examined blood parameters to the highest degree. The reference values ranges in hens blood serum LB hens were proposed for: TP (43-65 g/l), Albs (15-22 g/l), urea (0.5-1.2 mmol/l), Glu 10-15 mmol/l), TCh (2.2-4.5 mmol/l), TAG (10-24 mmol/l), AST (4-12 U/l), ALT (150-280 mmol/l) and ALP (190-350 U/l).

  3. Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study

    Directory of Open Access Journals (Sweden)

    Mariane Curado Borges

    Full Text Available Abstract Background: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP and other inflammatory mediators. Objective: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE. Methods: Experimental clinical study (clinical trial: NCT02524795; 49 women with SLE (ACR1982/1997 were randomized: 22 to the omega-3 group (daily intake of 1080 mg EPA + 200 mg DHA, for 12 weeks and 27 to the control group. The inflammatory mediators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann-Whitney test was used to compare variations of measured variables [ΔV = pre-treatment (T0 − post-treatment (T1 concentrations] between groups. p < 0.05 was considered significant. Results: The median (interquartile range - IQR of age was 37 (29-48 years old, of disease duration was 7 (4-13 years, and of SLEDAI-2K was 1 (0-2. The median (IQR of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p = 0.008. The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Conclusions: Supplementation with omega-3 had no impact on serum concentrations of IL-6, IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol.

  4. Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study.

    Science.gov (United States)

    Curado Borges, Mariane; de Miranda Moura Dos Santos, Fabiana; Weiss Telles, Rosa; Melo de Andrade, Marcus Vinícius; Toulson Davisson Correia, Maria Isabel; Lanna, Cristina Costa Duarte

    Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory mediators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann-Whitney test was used to compare variations of measured variables [ΔV=pre-treatment (T0)-post-treatment (T1) concentrations] between groups. p<0.05 was considered significant. The median (interquartile range - IQR) of age was 37 (29-48) years old, of disease duration was 7 (4-13) years, and of SLEDAI-2K was 1 (0-2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p=0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Supplementation with omega-3 had no impact on serum concentrations of IL-6, IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol. Copyright © 2016. Published by Elsevier Editora Ltda.

  5. Characterizing multistationarity regimes in biochemical reaction networks.

    Directory of Open Access Journals (Sweden)

    Irene Otero-Muras

    Full Text Available Switch like responses appear as common strategies in the regulation of cellular systems. Here we present a method to characterize bistable regimes in biochemical reaction networks that can be of use to both direct and reverse engineering of biological switches. In the design of a synthetic biological switch, it is important to study the capability for bistability of the underlying biochemical network structure. Chemical Reaction Network Theory (CRNT may help at this level to decide whether a given network has the capacity for multiple positive equilibria, based on their structural properties. However, in order to build a working switch, we also need to ensure that the bistability property is robust, by studying the conditions leading to the existence of two different steady states. In the reverse engineering of biological switches, knowledge collected about the bistable regimes of the underlying potential model structures can contribute at the model identification stage to a drastic reduction of the feasible region in the parameter space of search. In this work, we make use and extend previous results of the CRNT, aiming not only to discriminate whether a biochemical reaction network can exhibit multiple steady states, but also to determine the regions within the whole space of parameters capable of producing multistationarity. To that purpose we present and justify a condition on the parameters of biochemical networks for the appearance of multistationarity, and propose an efficient and reliable computational method to check its satisfaction through the parameter space.

  6. System Identification Theory Approach to Cohesive Sediment Transport Modelling

    OpenAIRE

    CHEN, HUIXIN

    1997-01-01

    Two aspects of the modelling sediment transport are investigated. One is the univariate time series modelling the current velocity dynamics. The other is the multivariate time series modelling the suspended sediment concentration dynamics. Cohesive sediment dynamics and numerical sediment transport model are reviewed and investigated. The system identification theory and time series analysis method are developed and applied to set up the time series model for current velocity a...

  7. Y-system for γ-deformed ABJM theory

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hui-Huang; Liu, Peng [Institute of High Energy Physics, and Theoretical Physics Center for Science Facilities,Chinese Academy of Sciences,19B Yuquan Road, Beijing 100049 (China); University of Chinese Academy of Sciences,19A Yuquan Road, Beijing 100049 (China); Wu, Jun-Bao [School of Science, University of Tianjin,92 Weijin Road, Tianjin 300072 (China); School of Physics and Nuclear Energy Engineering, Beihang University,37 Xueyuan Road, Beijing 100191 (China); Institute of High Energy Physics, and Theoretical Physics Center for Science Facilities,Chinese Academy of Sciences,19B Yuquan Road, Beijing 100049 (China); University of Chinese Academy of Sciences,19A Yuquan Road, Beijing 100049 (China); Center for High Energy Physics, Peking University,5 Yiheyuan Road, Beijing 100871 (China)

    2017-03-27

    We investigate the integrable aspects of the planar γ-deformed ABJM theory and propose the twisted asymptotic Bethe ansatz equations. A more general method through a twisted generating functional is discussed, based on which, the asymptotic large L solution of Y-system is modified in order to match the asymptotic Bethe ansatz equations. Several applications of our method in the sl(2)-like sector and some important examples in β-deformed ABJM are presented as well.

  8. Scale relativity theory and integrative systems biology: 2. Macroscopic quantum-type mechanics.

    Science.gov (United States)

    Nottale, Laurent; Auffray, Charles

    2008-05-01

    In these two companion papers, we provide an overview and a brief history of the multiple roots, current developments and recent advances of integrative systems biology and identify multiscale integration as its grand challenge. Then we introduce the fundamental principles and the successive steps that have been followed in the construction of the scale relativity theory, which aims at describing the effects of a non-differentiable and fractal (i.e., explicitly scale dependent) geometry of space-time. The first paper of this series was devoted, in this new framework, to the construction from first principles of scale laws of increasing complexity, and to the discussion of some tentative applications of these laws to biological systems. In this second review and perspective paper, we describe the effects induced by the internal fractal structures of trajectories on motion in standard space. Their main consequence is the transformation of classical dynamics into a generalized, quantum-like self-organized dynamics. A Schrödinger-type equation is derived as an integral of the geodesic equation in a fractal space. We then indicate how gauge fields can be constructed from a geometric re-interpretation of gauge transformations as scale transformations in fractal space-time. Finally, we introduce a new tentative development of the theory, in which quantum laws would hold also in scale space, introducing complexergy as a measure of organizational complexity. Initial possible applications of this extended framework to the processes of morphogenesis and the emergence of prokaryotic and eukaryotic cellular structures are discussed. Having founded elements of the evolutionary, developmental, biochemical and cellular theories on the first principles of scale relativity theory, we introduce proposals for the construction of an integrative theory of life and for the design and implementation of novel macroscopic quantum-type experiments and devices, and discuss their potential

  9. The theory of critical phenomena in two-dimensional systems

    International Nuclear Information System (INIS)

    Olvera de la C, M.

    1981-01-01

    An exposition of the theory of critical phenomena in two-dimensional physical systems is presented. The first six chapters deal with the mean field theory of critical phenomena, scale invariance of the thermodynamic functions, Kadanoff's spin block construction, Wilson's renormalization group treatment of critical phenomena in configuration space, and the two-dimensional Ising model on a triangular lattice. The second part of this work is made of four chapters devoted to the application of the ideas expounded in the first part to the discussion of critical phenomena in superfluid films, two-dimensional crystals and the two-dimensional XY model of magnetic systems. Chapters seven to ten are devoted to the following subjects: analysis of long range order in one, two, and three-dimensional physical systems. Topological defects in the XY model, in superfluid films and in two-dimensional crystals. The Thouless-Kosterlitz iterated mean field theory of the dipole gas. The renormalization group treatment of the XY model, superfluid films and two-dimensional crystal. (author)

  10. Stochastic systems with delay: Perturbation theory for second order statistics

    Energy Technology Data Exchange (ETDEWEB)

    Frank, T.D., E-mail: till.frank@uconn.edu

    2016-03-24

    Within the framework of delay Fokker–Planck equations, a perturbation theoretical method is developed to determine second-order statistical quantities such as autocorrelation functions for stochastic systems with delay. Two variants of the perturbation theoretical approach are presented. The first variant is based on a non-local Fokker–Planck operator. The second variant requires to solve a Fokker–Planck equation with source term. It is shown that the two variants yield consistent results. The perturbation theoretical approaches are applied to study negative autocorrelations that are induced by feedback delays and mediated by the strength of the fluctuating forces that act on the feedback systems. - Highlights: • A perturbation theory for stochastic delay systems is presented. • The perturbation theory yields second order statistical quantities. • The theory is developed within the framework of delay Fokker–Planck equations. • The effective Fokker–Planck operator is a non-local operator in space. • Negative autocorrelations can be induced by time-delayed feedback.

  11. Developing interprofessional education online: An ecological systems theory analysis.

    Science.gov (United States)

    Bluteau, Patricia; Clouder, Lynn; Cureton, Debra

    2017-07-01

    This article relates the findings of a discourse analysis of an online asynchronous interprofessional learning initiative involving two UK universities. The impact of the initiative is traced over three intensive periods of online interaction, each of several-weeks duration occurring over a three-year period, through an analysis of a random sample of discussion forum threads. The corpus of rich data drawn from the forums is interpreted using ecological systems theory, which highlights the complexity of interaction of individual, social and cultural elements. Ecological systems theory adopts a life course approach to understand how development occurs through processes of progressively more complex reciprocal interaction between people and their environment. This lens provides a novel approach for analysis and interpretation of findings with respect to the impact of pre-registration interprofessional education and the interaction between the individual and their social and cultural contexts as they progress through 3/4 years of their programmes. Development is mapped over time (the chronosystem) to highlight the complexity of interaction across microsystems (individual), mesosystems (curriculum and institutional/care settings), exosystems (community/wider local context), and macrosystems (national context and culture). This article illustrates the intricacies of students' interprofessional development over time and the interactive effects of social ecological components in terms of professional knowledge and understanding, wider appreciation of health and social care culture and identity work. The implications for contemporary pre-registration interprofessional education and the usefulness and applicability of ecological systems theory for future research and development are considered.

  12. The Systemic Theory of Living Systems. Part IV: Systemic Medicine—The Praxis

    Directory of Open Access Journals (Sweden)

    José A. Olalde Rangel

    2005-01-01

    Full Text Available This fourth lecture illustrates the praxis and results of Systemic Medicine (SM in various therapeutic applications. SM's success has made it popular throughout Venezuela and Puerto Rico. The treatment of over 300 000 patients by 150 orthodox MD's, trained and qualified in SM, in 35 medical establishments with above average results corroborate its effectiveness as an eCAM in chronic degenerative diseases. Herein we provide a synopsis of results obtained in four such pathologies—the journal's necessary space restrictions somewhat limiting content—as well as clinical and photographic evidence. The validity of any medical theory is substantiated by its degree of effectivity and success. The workability of evidence-based SM corroborates Systemic Theory's transcendence.

  13. Intrinsic Noise Analyzer: A Software Package for the Exploration of Stochastic Biochemical Kinetics Using the System Size Expansion

    Science.gov (United States)

    Grima, Ramon

    2012-01-01

    The accepted stochastic descriptions of biochemical dynamics under well-mixed conditions are given by the Chemical Master Equation and the Stochastic Simulation Algorithm, which are equivalent. The latter is a Monte-Carlo method, which, despite enjoying broad availability in a large number of existing software packages, is computationally expensive due to the huge amounts of ensemble averaging required for obtaining accurate statistical information. The former is a set of coupled differential-difference equations for the probability of the system being in any one of the possible mesoscopic states; these equations are typically computationally intractable because of the inherently large state space. Here we introduce the software package intrinsic Noise Analyzer (iNA), which allows for systematic analysis of stochastic biochemical kinetics by means of van Kampen’s system size expansion of the Chemical Master Equation. iNA is platform independent and supports the popular SBML format natively. The present implementation is the first to adopt a complementary approach that combines state-of-the-art analysis tools using the computer algebra system Ginac with traditional methods of stochastic simulation. iNA integrates two approximation methods based on the system size expansion, the Linear Noise Approximation and effective mesoscopic rate equations, which to-date have not been available to non-expert users, into an easy-to-use graphical user interface. In particular, the present methods allow for quick approximate analysis of time-dependent mean concentrations, variances, covariances and correlations coefficients, which typically outperforms stochastic simulations. These analytical tools are complemented by automated multi-core stochastic simulations with direct statistical evaluation and visualization. We showcase iNA’s performance by using it to explore the stochastic properties of cooperative and non-cooperative enzyme kinetics and a gene network associated with

  14. Stopped-flow system with ozonizer for the estimation of low biochemical oxygen demand in environmental samples.

    Science.gov (United States)

    Chee, Gab-Joo; Nomura, Yoko; Ikebukuro, Kazunori; Karube, Isao

    2007-06-15

    The stopped-flow system with an ozonizer was developed to estimate low biochemical oxygen demand (BOD) in rivers. Rivers contain many biopersistent organic compounds such as humic acid, lignin, and gum arabic. Free radicals generated by self-decomposition of ozone were used as powerful oxidants to split organic compounds. Ozonysis of the samples was carried out by 42.4 gN(-1)m(-3) ozone for 3 min at pH 7.0. Artificial wastewater (AWW) solutions were employed as standard solutions for the calibrations of the BOD sensor. At a BOD of 1 mgl(-1), the sensor response after ozonation was 1.6-fold higher than that before ozonation. The response time of the BOD sensor was only 5min, being independent of the concentrations, and the lower detection limit was 0.5 mgl(-1) BOD. The degradations of lignin and tannic acid by ozonation were 54.1 and 42.3%, respectively. In the biosensor responses by ozonation, lignin, gum arabic, and surfactant increased by double or more compared with previous responses. BOD in rivers was estimated using the stopped-flow system. Environmental samples pretreated with ozone gave high responses to the biosensor that were similar to those of the conventional BOD(5) method. Accordingly, a good correlation between the sensor and the conventional BOD(5) was obtained (r=0.989). The system has to evolve the highly sensitive BOD determination.

  15. Fabrication of a pen-shaped portable biochemical reaction system based on magnetic bead manipulation

    International Nuclear Information System (INIS)

    Shikida, Mitsuhiro; Inagaki, Noriyuki; Okochi, Mina; Honda, Hiroyuki; Sato, Kazuo

    2011-01-01

    A pen-shaped platform that is similar to a mechanical pencil is proposed for producing a portable reaction system. A reaction unit, as the key component in the system, was produced by using a heat shrinkable tube. A mechanical pencil supplied by Mitsubishi Pencil Co. Ltd was used as the pen-shaped platform for driving the reaction cylinder. It was actuated using an inchworm motion. We confirmed that the magnetic beads were successfully manipulated in the droplet in the cylinder-shaped reaction units. (technical note)

  16. Fundamental link between system theory and statistical mechanics

    International Nuclear Information System (INIS)

    Atmanspacher, H.; Scheingraber, H.

    1987-01-01

    A fundamental link between system theory and statistical mechanics has been found to be established by the Kolmogorov entropy. By this quantity the temporal evolution of dynamical systems can be classified into regular, chaotic, and stochastic processes. Since K represents a measure for the internal information creation rate of dynamical systems, it provides an approach to irreversibility. The formal relationship to statistical mechanics is derived by means of an operator formalism originally introduced by Prigogine. For a Liouville operator L and an information operator M tilde acting on a distribution in phase space, it is shown that i[L, M tilde] = KI (I = identity operator). As a first consequence of this equivalence, a relation is obtained between the chaotic correlation time of a system and Prigogine's concept of a finite duration of presence. Finally, the existence of chaos in quantum systems is discussed with respect to the existence of a quantum mechanical time operator

  17. Inter Annual Variability of the California Current System and Associated Biochemical Characteristics from Prolonged Data Series

    Science.gov (United States)

    2016-06-01

    47 Table 6. Variances of the First Six Leading EOFs of Synoptic Monthly Anomaly...59 Table 7. Variances of the First Six Leading EOF’s of Synoptic Monthly Anomaly ( Ĉ...CODE 13. ABSTRACT (maximum 200 words) This research investigates the California Current System (CCS) utilizing Synoptic Monthly Gridded World

  18. Unstable Systems and Quantum Zeno Phenomena in Quantum Field Theory

    Science.gov (United States)

    Facchi, P.; Pascazio, S.

    2003-02-01

    We analyze the Zeno phenomenon in quantum field theory. The decay of an unstable system can be modified by changing the time interval between successive measurements (or by varying the coupling to an external system that plays the role of measuring apparatus). We speak of quantum Zeno effect if the decay is slowed and of inverse quantum Zeno (or Heraclitus) effect if it is accelerated. The analysis of the transition between these two regimes requires close scrutiny of the features of the interaction Hamiltonian. We look in detail at quantum field theoretical models of the Lee type.

  19. A Hamilton-Jacobi theory for implicit differential systems

    Science.gov (United States)

    Esen, Oǧul; de León, Manuel; Sardón, Cristina

    2018-02-01

    In this paper, we propose a geometric Hamilton-Jacobi theory for systems of implicit differential equations. In particular, we are interested in implicit Hamiltonian systems, described in terms of Lagrangian submanifolds of TT*Q generated by Morse families. The implicit character implies the nonexistence of a Hamiltonian function describing the dynamics. This fact is here amended by a generating family of Morse functions which plays the role of a Hamiltonian. A Hamilton-Jacobi equation is obtained with the aid of this generating family of functions. To conclude, we apply our results to singular Lagrangians by employing the construction of special symplectic structures.

  20. Game Theory and Risk-Based Levee System Design

    Science.gov (United States)

    Hui, R.; Lund, J. R.; Madani, K.

    2014-12-01

    Risk-based analysis has been developed for optimal levee design for economic efficiency. Along many rivers, two levees on opposite riverbanks act as a simple levee system. Being rational and self-interested, land owners on each river bank would tend to independently optimize their levees with risk-based analysis, resulting in a Pareto-inefficient levee system design from the social planner's perspective. Game theory is applied in this study to analyze decision making process in a simple levee system in which the land owners on each river bank develop their design strategies using risk-based economic optimization. For each land owner, the annual expected total cost includes expected annual damage cost and annualized construction cost. The non-cooperative Nash equilibrium is identified and compared to the social planner's optimal distribution of flood risk and damage cost throughout the system which results in the minimum total flood cost for the system. The social planner's optimal solution is not feasible without appropriate level of compensation for the transferred flood risk to guarantee and improve conditions for all parties. Therefore, cooperative game theory is then employed to develop an economically optimal design that can be implemented in practice. By examining the game in the reversible and irreversible decision making modes, the cost of decision making myopia is calculated to underline the significance of considering the externalities and evolution path of dynamic water resource problems for optimal decision making.

  1. Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory.

    Directory of Open Access Journals (Sweden)

    Evgeni V Nikolaev

    2016-04-01

    , performed for a biochemically-detailed and biologically-relevant model that we developed. Another novel feature of our approach is that our theorems on exponential stability of steady states for homogeneous or mixed populations are valid independently of the number N of cells in the population, which is usually very large (N ≫ 1 and unknown. We prove that the exponential stability depends on relative proportions of each type of state only. While monotone systems theory has been used previously for systems biology analysis, the current work illustrates its power for synthetic biology design, and thus has wider significance well beyond the application to the important problem of coordination of toggle switches.

  2. Review and application of group theory to molecular systems biology

    Directory of Open Access Journals (Sweden)

    Rietman Edward A

    2011-06-01

    Full Text Available Abstract In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to molecular systems biology. Throughout this paper we briefly describe possible open problems. In connection with the genetic code we propose that it may be possible to use perturbation theory to explore the adjacent possibilities in the 64-dimensional space-time manifold of the evolving genome. With regards to algebraic graph theory, there are several minor open problems we discuss. In relation to network dynamics and groupoid formalism we suggest that the network graph might not be the main focus for understanding the phenotype but rather the phase space of the network dynamics. We show a simple case of a C6 network and its phase space network. We envision that the molecular network of a cell is actually a complex network of hypercycles and feedback circuits that could be better represented in a higher-dimensional space. We conjecture that targeting nodes in the molecular network that have key roles in the phase space, as revealed by analysis of the automorphism decomposition, might be a better way to drug discovery and treatment of cancer.

  3. Review and application of group theory to molecular systems biology.

    Science.gov (United States)

    Rietman, Edward A; Karp, Robert L; Tuszynski, Jack A

    2011-06-22

    In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to molecular systems biology. Throughout this paper we briefly describe possible open problems. In connection with the genetic code we propose that it may be possible to use perturbation theory to explore the adjacent possibilities in the 64-dimensional space-time manifold of the evolving genome. With regards to algebraic graph theory, there are several minor open problems we discuss. In relation to network dynamics and groupoid formalism we suggest that the network graph might not be the main focus for understanding the phenotype but rather the phase space of the network dynamics. We show a simple case of a C6 network and its phase space network. We envision that the molecular network of a cell is actually a complex network of hypercycles and feedback circuits that could be better represented in a higher-dimensional space. We conjecture that targeting nodes in the molecular network that have key roles in the phase space, as revealed by analysis of the automorphism decomposition, might be a better way to drug discovery and treatment of cancer.

  4. Disformal theories of gravity: from the solar system to cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Sakstein, Jeremy, E-mail: j.a.sakstein@damtp.cam.ac.uk [DAMTP, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2014-12-01

    This paper is concerned with theories of gravity that contain a scalar coupled both conformally and disformally to matter through the metric. By systematically deriving the non-relativistic limit, it is shown that no new non-linear screening mechanisms are present beyond the Vainshtein mechanism and chameleon-like screening. If one includes the cosmological expansion of the universe, disformal effects that are usually taken to be absent can be present in the solar system. When the conformal factor is absent, fifth-forces can be screened on all scales when the cosmological field is slowly-rolling. We investigate the cosmology of these models and use local tests of gravity to place new constraints on the disformal coupling and find M ∼> O(eV), which is not competitive with laboratory tests. Finally, we discuss the future prospects for testing these theories and the implications for other theories of modified gravity. In particular, the Vainshtein radius of solar system objects can be altered from the static prediction when cosmological time-derivatives are non-negligible.

  5. Applications of fuzzy theories to multi-objective system optimization

    Science.gov (United States)

    Rao, S. S.; Dhingra, A. K.

    1991-01-01

    Most of the computer aided design techniques developed so far deal with the optimization of a single objective function over the feasible design space. However, there often exist several engineering design problems which require a simultaneous consideration of several objective functions. This work presents several techniques of multiobjective optimization. In addition, a new formulation, based on fuzzy theories, is also introduced for the solution of multiobjective system optimization problems. The fuzzy formulation is useful in dealing with systems which are described imprecisely using fuzzy terms such as, 'sufficiently large', 'very strong', or 'satisfactory'. The proposed theory translates the imprecise linguistic statements and multiple objectives into equivalent crisp mathematical statements using fuzzy logic. The effectiveness of all the methodologies and theories presented is illustrated by formulating and solving two different engineering design problems. The first one involves the flight trajectory optimization and the main rotor design of helicopters. The second one is concerned with the integrated kinematic-dynamic synthesis of planar mechanisms. The use and effectiveness of nonlinear membership functions in fuzzy formulation is also demonstrated. The numerical results indicate that the fuzzy formulation could yield results which are qualitatively different from those provided by the crisp formulation. It is felt that the fuzzy formulation will handle real life design problems on a more rational basis.

  6. BIOCHEM-ORCHESTRA: A tool for evaluating chemical speciation and ecotoxicological impacts of heavy metals on river flood plain systems

    International Nuclear Information System (INIS)

    Vink, J.P.M.; Meeussen, J.C.L.

    2007-01-01

    The chemical speciation model BIOCHEM was extended with ecotoxicological transfer functions for uptake of metals (As, Cd, Cu, Ni, Pb, and Zn) by plants and soil invertebrates. It was coupled to the object-oriented framework ORCHESTRA to achieve a flexible and dynamic decision support system (DSS) to analyse natural or anthropogenic changes that occur in river systems. The DSS uses the chemical characteristics of soils and sediments as input, and calculates speciation and subsequent uptake by biota at various scenarios. Biotic transfer functions were field-validated, and actual hydrological conditions were derived from long-term monitoring data. The DSS was tested for several scenarios that occur in the Meuse catchment areas, such as flooding and sedimentation of riverine sediments on flood plains. Risks are expressed in terms of changes in chemical mobility, and uptake by flood plain key species (flora and fauna). - A diagnostic risk-assessment tool for heavy metals, based on biotic and abiotic interactions, compares risks under different environmental scenarios

  7. Prediction of biochemical oxygen demand at the upstream catchment of a reservoir using adaptive neuro fuzzy inference system.

    Science.gov (United States)

    Chiu, Yung-Chia; Chiang, Chih-Wei; Lee, Tsung-Yu

    2017-10-01

    The aim of this study is to examine the potential of adaptive neuro fuzzy inference system (ANFIS) to estimate biochemical oxygen demand (BOD). To illustrate the applicability of ANFIS method, the upstream catchment of Feitsui Reservoir in Taiwan is chosen as the case study area. The appropriate input variables used to develop the ANFIS models are determined based on the t-test. The results obtained by ANFIS are compared with those by multiple linear regression (MLR) and artificial neural networks (ANNs). Simulated results show that the identified ANFIS model is superior to the traditional MLR and nonlinear ANNs models in terms of the performance evaluated by the Pearson coefficient of correlation, the root mean square error, the mean absolute percentage, and the mean absolute error. These results indicate that ANFIS models are more suitable than ANNs or MLR models to predict the nonlinear relationship within the variables caused by the complexity of aquatic systems and to produce the best fit of the measured BOD concentrations. ANFIS can be seen as a powerful predictive alternative to traditional water quality modeling techniques and extended to other areas to improve the understanding of river pollution trends.

  8. [Clinical, biochemical and allergological indices characterizing occupational diseases of the bronchial and pulmonary system in employees at aluminium production].

    Science.gov (United States)

    Kudaeva, I V; Dyakovich, O A; Beygel, E A; Masnavieva, L B; Naumova, O V; Budarina, L A

    There are many harmful factors that possess a damaging impact on the body of employees at aluminum production. It leads to the development of bronchial asthma (BA), chronic nonobstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD). The pathogenesis of these disorders, as well as sensitizing effect offluorine in the aluminum production is not fully understood. The purpose of this work was to study the characteristics of laboratory indices in patients with occupational diseases of the respiratory system. In workers of aluminum production with the diagnosis of occupational diseases of respiratory system (15 patients with a diagnosis of asthma, 30 CNB cases, 20 COPD patients) we evaluated the content of total protein, total cholesterol, high density lipoprotein cholesterol (HDLC), total calcium, phosphorus, ceruloplasmin, hematological indices and performed emigration of leukocytes braking test (TTEEL). Clinical and biochemical profile ofpersons with occupational asthma was characterized by a low level of total calcium and ceruloplasmin, a high concentration of phosphorus in the blood serum and inhibition of leukocyte emigration in the test with sodium fluoride. For aluminum production CNB workers characteristic active proatherogenic process was pronounced by a decrease in the HDLC level and an increase in atherogenic index; higher hematocrit value and concentration of erythrocytes, and more than 50% of cases of sensitization to the presence of sodium fluoride. COPD cases had occupational lower average concentration of hemoglobin in the erythrocyte, total protein in serum, as well as polymorphic variant response to sodium fluoride in the form of a depression and activation of leucocytes emigration.

  9. A Comparison of Deterministic and Stochastic Modeling Approaches for Biochemical Reaction Systems: On Fixed Points, Means, and Modes

    Science.gov (United States)

    Hahl, Sayuri K.; Kremling, Andreas

    2016-01-01

    In the mathematical modeling of biochemical reactions, a convenient standard approach is to use ordinary differential equations (ODEs) that follow the law of mass action. However, this deterministic ansatz is based on simplifications; in particular, it neglects noise, which is inherent to biological processes. In contrast, the stochasticity of reactions is captured in detail by the discrete chemical master equation (CME). Therefore, the CME is frequently applied to mesoscopic systems, where copy numbers of involved components are small and random fluctuations are thus significant. Here, we compare those two common modeling approaches, aiming at identifying parallels and discrepancies between deterministic variables and possible stochastic counterparts like the mean or modes of the state space probability distribution. To that end, a mathematically flexible reaction scheme of autoregulatory gene expression is translated into the corresponding ODE and CME formulations. We show that in the thermodynamic limit, deterministic stable fixed points usually correspond well to the modes in the stationary probability distribution. However, this connection might be disrupted in small systems. The discrepancies are characterized and systematically traced back to the magnitude of the stoichiometric coefficients and to the presence of nonlinear reactions. These factors are found to synergistically promote large and highly asymmetric fluctuations. As a consequence, bistable but unimodal, and monostable but bimodal systems can emerge. This clearly challenges the role of ODE modeling in the description of cellular signaling and regulation, where some of the involved components usually occur in low copy numbers. Nevertheless, systems whose bimodality originates from deterministic bistability are found to sustain a more robust separation of the two states compared to bimodal, but monostable systems. In regulatory circuits that require precise coordination, ODE modeling is thus still

  10. Regularity Theory for Mean-Field Game Systems

    KAUST Repository

    Gomes, Diogo A.

    2016-09-14

    Beginning with a concise introduction to the theory of mean-field games (MFGs), this book presents the key elements of the regularity theory for MFGs. It then introduces a series of techniques for well-posedness in the context of mean-field problems, including stationary and time-dependent MFGs, subquadratic and superquadratic MFG formulations, and distinct classes of mean-field couplings. It also explores stationary and time-dependent MFGs through a series of a-priori estimates for solutions of the Hamilton-Jacobi and Fokker-Planck equation. It shows sophisticated a-priori systems derived using a range of analytical techniques, and builds on previous results to explain classical solutions. The final chapter discusses the potential applications, models and natural extensions of MFGs. As MFGs connect common problems in pure mathematics, engineering, economics and data management, this book is a valuable resource for researchers and graduate students in these fields.

  11. Regularity theory for mean-field game systems

    CERN Document Server

    Gomes, Diogo A; Voskanyan, Vardan

    2016-01-01

    Beginning with a concise introduction to the theory of mean-field games (MFGs), this book presents the key elements of the regularity theory for MFGs. It then introduces a series of techniques for well-posedness in the context of mean-field problems, including stationary and time-dependent MFGs, subquadratic and superquadratic MFG formulations, and distinct classes of mean-field couplings. It also explores stationary and time-dependent MFGs through a series of a-priori estimates for solutions of the Hamilton-Jacobi and Fokker-Planck equation. It shows sophisticated a-priori systems derived using a range of analytical techniques, and builds on previous results to explain classical solutions. The final chapter discusses the potential applications, models and natural extensions of MFGs. As MFGs connect common problems in pure mathematics, engineering, economics and data management, this book is a valuable resource for researchers and graduate students in these fields.

  12. LASSIE: simulating large-scale models of biochemical systems on GPUs.

    Science.gov (United States)

    Tangherloni, Andrea; Nobile, Marco S; Besozzi, Daniela; Mauri, Giancarlo; Cazzaniga, Paolo

    2017-05-10

    Mathematical modeling and in silico analysis are widely acknowledged as complementary tools to biological laboratory methods, to achieve a thorough understanding of emergent behaviors of cellular processes in both physiological and perturbed conditions. Though, the simulation of large-scale models-consisting in hundreds or thousands of reactions and molecular species-can rapidly overtake the capabilities of Central Processing Units (CPUs). The purpose of this work is to exploit alternative high-performance computing solutions, such as Graphics Processing Units (GPUs), to allow the investigation of these models at reduced computational costs. LASSIE is a "black-box" GPU-accelerated deterministic simulator, specifically designed for large-scale models and not requiring any expertise in mathematical modeling, simulation algorithms or GPU programming. Given a reaction-based model of a cellular process, LASSIE automatically generates the corresponding system of Ordinary Differential Equations (ODEs), assuming mass-action kinetics. The numerical solution of the ODEs is obtained by automatically switching between the Runge-Kutta-Fehlberg method in the absence of stiffness, and the Backward Differentiation Formulae of first order in presence of stiffness. The computational performance of LASSIE are assessed using a set of randomly generated synthetic reaction-based models of increasing size, ranging from 64 to 8192 reactions and species, and compared to a CPU-implementation of the LSODA numerical integration algorithm. LASSIE adopts a novel fine-grained parallelization strategy to distribute on the GPU cores all the calculations required to solve the system of ODEs. By virtue of this implementation, LASSIE achieves up to 92× speed-up with respect to LSODA, therefore reducing the running time from approximately 1 month down to 8 h to simulate models consisting in, for instance, four thousands of reactions and species. Notably, thanks to its smaller memory footprint, LASSIE

  13. Designing a reusable system based on nanodiamonds for biochemical determination of urea.

    Science.gov (United States)

    Ronzhin, N O; Baron, A V; Bondar, V S; Gitelson, I I

    2015-01-01

    A reusable system including urease covalently bound to the surface of modified nanodiamonds (MNDs) has been developed for the multiple determination of urea. The immobilized enzyme exhibits functional activity and catalyzes the hydrolysis of urea to yield ammonia. The presence of ammonia is confirmed by the formation of a colored product after the addition of chemical reagents. It was shown that the MNDs-urease complex can function in a wide range of temperatures and pH as well as in deionized water. The complex provides a linear yield of the product at low analyte concentrations and allows the multiple determination of urea in vitro.

  14. Classical and Quantum Nonlinear Integrable Systems: Theory and Application

    International Nuclear Information System (INIS)

    Brzezinski, Tomasz

    2003-01-01

    This is a very interesting collection of introductory and review articles on the theory and applications of classical and quantum integrable systems. The book reviews several integrable systems such as the KdV equation, vertex models, RSOS and IRF models, spin chains, integrable differential equations, discrete systems, Ising, Potts and other lattice models and reaction--diffusion processes, as well as outlining major methods of solving integrable systems. These include Lax pairs, Baecklund and Miura transformations, the inverse scattering method, various types of the Bethe Ansatz, Painleve methods, the dbar method and fusion methods to mention just a few. The book is divided into two parts, each containing five chapters. The first part is devoted to classical integrable systems and introduces the subject through the KdV equation, and then proceeds through Painleve analysis, discrete systems and two-dimensional integrable partial differential equations, to culminate in the review of solvable lattice models in statistical physics, solved through the coordinate and algebraic Bethe Ansatz methods. The second part deals with quantum integrable systems, and begins with an outline of unifying approaches to quantum, statistical, ultralocal and non-ultralocal systems. The theory and methods of solving quantum integrable spin chains are then described. Recent developments in applying Bethe Ansatz methods in condensed matter physics, including superconductivity and nanoscale physics, are reviewed. The book concludes with an introduction to diffusion-reaction processes. Every chapter is devoted to a different subject and is self-contained, and thus can be read separately. A reader interesting in classical methods of solitons, such as the methods of solving the KdV equation, can start from Chapter 1, while a reader interested in the Bethe Ansatz method can immediately proceed to Chapter 5, and so on. Thus the book should appeal and be useful to a wide range of theoretical

  15. Power System Transient Stability Based on Data Mining Theory

    Science.gov (United States)

    Cui, Zhen; Shi, Jia; Wu, Runsheng; Lu, Dan; Cui, Mingde

    2018-01-01

    In order to study the stability of power system, a power system transient stability based on data mining theory is designed. By introducing association rules analysis in data mining theory, an association classification method for transient stability assessment is presented. A mathematical model of transient stability assessment based on data mining technology is established. Meanwhile, combining rule reasoning with classification prediction, the method of association classification is proposed to perform transient stability assessment. The transient stability index is used to identify the samples that cannot be correctly classified in association classification. Then, according to the critical stability of each sample, the time domain simulation method is used to determine the state, so as to ensure the accuracy of the final results. The results show that this stability assessment system can improve the speed of operation under the premise that the analysis result is completely correct, and the improved algorithm can find out the inherent relation between the change of power system operation mode and the change of transient stability degree.

  16. Modelling of Mass Transfer Phenomena in Chemical and Biochemical Reactor Systems using Computational Fluid Dynamics

    DEFF Research Database (Denmark)

    Larsson, Hilde Kristina

    Computational fluid dynamics (CFD) is the application of numerical methods to solve systems of partial differential equations related to fluid dynamics. The continuity and the momentum equations are the most commonly applied equations within CFD, and together they can be used to calculate...... the velocity and pressure distributions in a fluid. CFD also enables the modelling of several fluids simultaneously, e.g. gas bubbles in a liquid, as well as the presence of turbulence and dissolved chemicals in a fluid, and many other phenomena. This makes CFD an appreciated tool for studying flow structures...... and an ion-exchange reaction are also modelled and compared to experimental data. The thesis includes a comprehensive overview of the fundamentals behind a CFD software, as well as a more detailed review of the fluid dynamic phenomena investigated in this project. The momentum and continuity equations...

  17. Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis

    Science.gov (United States)

    Jensen, Erik C.; Zeng, Yong; Kim, Jungkyu; Mathies, Richard A.

    2010-01-01

    Microfluidic devices offer unparalleled capability for digital microfluidic automation of sample processing and complex assay protocols in medical diagnostic and research applications. In our own work, monolithic membrane valves have enabled the creation of two platforms that precisely manipulate discrete, nanoliter-scale volumes of sample. The digital microfluidic Automaton uses two-dimensional microvalve arrays to combinatorially process nanoliter-scale sample volumes. This programmable system enables rapid integration of diverse assay protocols using a universal processing architecture. Microfabricated emulsion generator array (MEGA) devices integrate actively controlled 3-microvalve pumps to enable on-demand generation of uniform droplets for statistical encapsulation of microbeads and cells. A MEGA device containing 96 channels confers the capability of generating up to 3.4 × 106 nanoliter-volume droplets per hour for ultrahigh-throughput detection of rare mutations in a vast background of normal genotypes. These novel digital microfluidic platforms offer significant enhancements in throughput, sensitivity, and programmability for automated sample processing and analysis. PMID:21218162

  18. Biologically inspired information theory: Adaptation through construction of external reality models by living systems.

    Science.gov (United States)

    Nakajima, Toshiyuki

    2015-12-01

    Higher animals act in the world using their external reality models to cope with the uncertain environment. Organisms that have not developed such information-processing organs may also have external reality models built in the form of their biochemical, physiological, and behavioral structures, acquired by natural selection through successful models constructed internally. Organisms subject to illusions would fail to survive in the material universe. How can organisms, or living systems in general, determine the external reality from within? This paper starts with a phenomenological model, in which the self constitutes a reality model developed through the mental processing of phenomena. Then, the it-from-bit concept is formalized using a simple mathematical model. For this formalization, my previous work on an algorithmic process is employed to constitute symbols referring to the external reality, called the inverse causality, with additional improvements to the previous work. Finally, as an extension of this model, the cognizers system model is employed to describe the self as one of many material entities in a world, each of which acts as a subject by responding to the surrounding entities. This model is used to propose a conceptual framework of information theory that can deal with both the qualitative (semantic) and quantitative aspects of the information involved in biological processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Theory of hybrid dynamical systems and its applications to biological and medical systems.

    Science.gov (United States)

    Aihara, Kazuyuki; Suzuki, Hideyuki

    2010-11-13

    In this introductory article, we survey the contents of this Theme Issue. This Theme Issue deals with a fertile region of hybrid dynamical systems that are characterized by the coexistence of continuous and discrete dynamics. It is now well known that there exist many hybrid dynamical systems with discontinuities such as impact, switching, friction and sliding. The first aim of this Issue is to discuss recent developments in understanding nonlinear dynamics of hybrid dynamical systems in the two main theoretical fields of dynamical systems theory and control systems theory. A combined study of the hybrid systems dynamics in the two theoretical fields might contribute to a more comprehensive understanding of hybrid dynamical systems. In addition, mathematical modelling by hybrid dynamical systems is particularly important for understanding the nonlinear dynamics of biological and medical systems as they have many discontinuities such as threshold-triggered firing in neurons, on-off switching of gene expression by a transcription factor, division in cells and certain types of chronotherapy for prostate cancer. Hence, the second aim is to discuss recent applications of hybrid dynamical systems in biology and medicine. Thus, this Issue is not only general to serve as a survey of recent progress in hybrid systems theory but also specific to introduce interesting and stimulating applications of hybrid systems in biology and medicine. As the introduction to the topics in this Theme Issue, we provide a brief history of nonlinear dynamics and mathematical modelling, different mathematical models of hybrid dynamical systems, the relationship between dynamical systems theory and control systems theory, examples of complex behaviour in a simple neuron model and its variants, applications of hybrid dynamical systems in biology and medicine as a road map of articles in this Theme Issue and future directions of hybrid systems modelling.

  20. Weird astronomical theories of the solar system and beyond

    CERN Document Server

    Seargent, David

    2016-01-01

    After addressing strange cosmological hypotheses in Weird Universe, David Seargent tackles the no-less bizarre theories closer to home. Alternate views on the Solar System's formation, comet composition, and the evolution of life on Earth are only some of the topics he addresses in this new work. Although these ideas exist on the fringe of mainstream astronomy, they can still shed light on the origins of life and the evolution of the planets. Continuing the author's series of books popularizing strange astronomy facts and knowledge, Weird Astronomical Theories presents an approachable exploration of the still mysterious questions about the origin of comets, the pattern of mass extinctions on Earth, and more. The alternative theories discussed here do not come from untrained amateurs. The scientists whose work is covered includes the mid-20th century Russian S. K. Vsekhsvyatskii, cosmologist Max Tegmark, British astronomers Victor Clube and William Napier, and American Tom Van Flandern, a special...

  1. General Systems Theory: Application To The Design Of Speech Communication Courses

    Science.gov (United States)

    Tucker, Raymond K.

    1971-01-01

    General systems theory can be applied to problems in the teaching of speech communication courses. The author describes general systems theory as it is applied to the designing, conducting and evaluation of speech communication courses. (Author/MS)

  2. Using Ontological Engineering to Organize Learning/Instructional Theories and Build a Theory-Aware Authoring System

    Science.gov (United States)

    Hayashi, Yusuke; Bourdeau, Jacqueline; Mizoguchi, Riichiro

    2009-01-01

    This paper describes the achievements of an innovative eight-year research program first introduced in Mizoguchi and Bourdeau (2000), which was aimed at building a theory-aware authoring system by using ontological engineering. To date, we have proposed OMNIBUS, an ontology that comprehensively covers different learning/instructional theories and…

  3. Kinetic theory of the quantum field system with unstable vacuum

    International Nuclear Information System (INIS)

    Smolyanskij, S.A.; Prozorkevich, A.V.; Skokov, V.V.

    2005-01-01

    The description of quantum field systems with meta-stable vacuum is motivated by studies of many physical problems (η-meson sector of the Witten-Di Vecchia-Veneziano model, disoriented chiral condensate, false vacuum decay in inflation cosmological models, etc.). A nonperturbative approach based on the kinetic description within the framework of the quasiparticle representation is proposed. We restrict ourselves to scalar field theory with self-interaction potential having a nontrivial set of vacuum states. If the vacuum state is not uniquely defined, the quasiparticle definition is introduced by some physical reason. As a result, we obtain the self-consistent system of the kinetic equation for quasiparticle distribution function and the equation of motion for the background field. Two examples - the quantum field system with φ 4 and double-well type potential - are considered

  4. The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis.

    Science.gov (United States)

    Chiefari, Eusebio; Paonessa, Francesco; Iiritano, Stefania; Le Pera, Ilaria; Palmieri, Dario; Brunetti, Giuseppe; Lupo, Angelo; Colantuoni, Vittorio; Foti, Daniela; Gulletta, Elio; De Sarro, Giovambattista; Fusco, Alfredo; Brunetti, Antonio

    2009-05-21

    simultaneously increased. These results indicate that HMGA1 is an important modulator of RBP4 gene expression in vivo. Further, they provide evidence for the identification of a novel biochemical pathway involving the cAMP-HMGA1-RBP4 system, whose activation may play a role in glucose homeostasis in both rodents and humans. Elucidating these mechanisms has importance for both fundamental biology and therapeutic implications.

  5. Keldysh field theory for driven open quantum systems.

    Science.gov (United States)

    Sieberer, L M; Buchhold, M; Diehl, S

    2016-09-01

    Recent experimental developments in diverse areas-ranging from cold atomic gases to light-driven semiconductors to microcavity arrays-move systems into the focus which are located on the interface of quantum optics, many-body physics and statistical mechanics. They share in common that coherent and driven-dissipative quantum dynamics occur on an equal footing, creating genuine non-equilibrium scenarios without immediate counterpart in equilibrium condensed matter physics. This concerns both their non-thermal stationary states and their many-body time evolution. It is a challenge to theory to identify novel instances of universal emergent macroscopic phenomena, which are tied unambiguously and in an observable way to the microscopic drive conditions. In this review, we discuss some recent results in this direction. Moreover, we provide a systematic introduction to the open system Keldysh functional integral approach, which is the proper technical tool to accomplish a merger of quantum optics and many-body physics, and leverages the power of modern quantum field theory to driven open quantum systems.

  6. The dispersion-focalization theory of sound systems

    Science.gov (United States)

    Schwartz, Jean-Luc; Abry, Christian; Boë, Louis-Jean; Vallée, Nathalie; Ménard, Lucie

    2005-04-01

    The Dispersion-Focalization Theory states that sound systems in human languages are shaped by two major perceptual constraints: dispersion driving auditory contrast towards maximal or sufficient values [B. Lindblom, J. Phonetics 18, 135-152 (1990)] and focalization driving auditory spectra towards patterns with close neighboring formants. Dispersion is computed from the sum of the inverse squared inter-spectra distances in the (F1, F2, F3, F4) space, using a non-linear process based on the 3.5 Bark critical distance to estimate F2'. Focalization is based on the idea that close neighboring formants produce vowel spectra with marked peaks, easier to process and memorize in the auditory system. Evidence for increased stability of focal vowels in short-term memory was provided in a discrimination experiment on adult French subjects [J. L. Schwartz and P. Escudier, Speech Comm. 8, 235-259 (1989)]. A reanalysis of infant discrimination data shows that focalization could well be the responsible for recurrent discrimination asymmetries [J. L. Schwartz et al., Speech Comm. (in press)]. Recent data about children vowel production indicate that focalization seems to be part of the perceptual templates driving speech development. The Dispersion-Focalization Theory produces valid predictions for both vowel and consonant systems, in relation with available databases of human languages inventories.

  7. An evaluation of the Oxoid Biochemical Identification System Campy rapid screening test for Campylobacteraceae and Helicobacter spp.

    Science.gov (United States)

    Hoosain, N; Lastovica, A J

    2009-06-01

    To evaluate the Oxoid Biochemical Identification System (OBIS) Campy test (ID0800M) against Campylobacter; Arcobacter; and other micro-organisms, with similar colonial morphology, for the detection of l-alanine aminopeptidase (l-ALA). The KOH and l-ALA (OBIS and Fluka) tests were carried out on every isolate. The procedures were followed as indicated in the OBIS and Fluka kit instructions. A total of 146 strains of 19 species of Campylobacter, seven strains of Arcobacter butzleri, four Arcobacter butzleri-like strains, 42 strains of 10 species of Helicobacter, 96 Gram-negative and 49 Gram-positive clinical isolates were tested. As expected, Campylobacter and Arcobacter strains were negative, while other Gram-negative bacteria were positive for the l-ALA test. An unexpected finding was that Helicobacter strains, although Gram-negative, were all negative for the l-ALA tests suggesting the absence of l-ALA within this genus. This is a novel finding. The absence of l-ALA was confirmed upon comparison with the available full genomic sequences of Helicobacter on the NCBI database. The OBIS Campy (ID0800M) test kit proved to be rapid and accurate for the presumptive characterization of Campylobacter and Arcobacter. A novel finding was that Helicobacter species also did not have the l-ALA enzyme. The OBIS kit will be useful in diagnostic laboratories for the presumptive diagnosis of Campylobacter, Arcobacter and Helicobacter strains.

  8. An optical biosensing film for biochemical oxygen demand determination in seawater with an automatic flow sampling system

    Science.gov (United States)

    Xin, Lingling; Wang, Xudong; Guo, Guangmei; Wang, Xiaoru; Chen, Xi

    2007-09-01

    An on-line roboticized apparatus, including an optical biosensing film with an automatic flow sampling system, has been developed for biochemical oxygen demand (BOD) determination of seawater. The sensing film employed in the apparatus consisted of an organically modified silicate (ORMOSIL) film embedded with tri(4,7-diphenyl-1,10-phenanthroline) ruthenium(II) perchlorate. Three species of microorganism cultivated from seawater were immobilized in an ORMOSIL-polyvinyl alcohol matrix. Possible factors affecting BOD determination were studied, including sampling frequency, temperature, pH and sodium chloride concentration. Based on measurements of the linear fluctuant coefficients and the reproducibility of its response to seawater, the BOD apparatus showed the advantages of high veracity and short response time. Generally, the linear fluctuant coefficient (R2) in the BOD range 0.2-40 mg l-1 was 0.9945 when using a glucose/glutamate (GGA) BOD standard solution. A reproducible response for the BOD sensing film of within ±2.8% could be obtained in the 2 mg l-1 GGA solution. The BOD apparatus was applied to the BOD determination of seawater, and the values estimated by this biosensing apparatus correlated well with those determined by the conventional 5 day BOD (BOD5) test.

  9. Development theory and changes in the international system

    Directory of Open Access Journals (Sweden)

    José Antonio Alonso

    2012-12-01

    Full Text Available Development theory has undergone several changes over the last two decades. However, the international reality has changed more profoundly. The increased heterogeneity of the developing world, the diverse experience of economic success among some developing countries, the new geography of global poverty, the increased multipolarity of the international system and the wider spheres of international public assets are just some of these changes. Thus, it is necessary to think again about the development process and the strategies that are required to promote economic and social change. This article represents an attempt to contribute to that reflection.

  10. Application of Density Functional Theory to Systems Containing Metal Atoms

    Science.gov (United States)

    Bauschlicher, Charles W., Jr.

    2006-01-01

    The accuracy of density functional theory (DFT) for problems involving metal atoms is considered. The DFT results are compared with experiment as well as results obtained using the coupled cluster approach. The comparisons include geometries, frequencies, and bond energies. The systems considered include MO2, M(OH)+n, MNO+, and MCO+2. The DFT works well for frequencies and geometries, even in case with symmetry breaking; however, some examples have been found where the symmetry breaking is quite severe and the DFT methods do not work well. The calculation of bond energies is more difficult and examples of successes as well as failures of DFT will be given.

  11. International conference on dynamical systems and game theory

    CERN Document Server

    Peixoto, Mauricio Matos; Rand, David A J; Dynamics, Games and Science II

    2011-01-01

    "Dynamics, Games and Science I and II" are a selection of surveys and research articles written by leading researchers in mathematics and its applications to the sciences. The majority of the contributions are on dynamical systems and game theory, focusing either on some of their most fundamental and theoretical developments or on their applications to modeling in biology, economics, engineering, finances and psychology. The aim of these books is to present cutting-edge research in these areas that can encourage graduate students and researchers in mathematics to develop them further

  12. Renormalized perturbation theory: Vlasov-Poisson System, weak turbulence limit and gyrokinetics

    International Nuclear Information System (INIS)

    Zhang, Y.Z.; Mahajan, S.M.

    1987-10-01

    The Self-consistency of the renormalized perturbation theory is demonstrated by applying it to the Vlasov-Poisson System and showing that the theory has the correct weak turbulence limit. Energy conservation is proved to arbitrary high order for the electrostatic drift waves. The theory is applied to derive renormalized equations for a low-β gyrokinetic system. Comparison of our theory with other current theories is presented. 22 refs

  13. Embedding research in health systems: lessons from complexity theory.

    Science.gov (United States)

    Caffrey, Louise; Wolfe, Charles; McKevitt, Christopher

    2016-07-22

    Internationally, there has been increasing focus on creating health research systems. This article aims to investigate the challenges of implementing apparently simple strategies to support the development of a health research system. We focus on a case study of an English National Health Service Hospital Trust that sought to implement the national recommendation that health organisations should introduce a statement about research on all patient admission letters. We apply core concepts from complexity theory to the case study and undertake a documentary analysis of the email dialogue between staff involved in implementing this initiative. The process of implementing a research statement in patient admission letters in one clinical service took 1 year and 21 days. The length of time needed was influenced firstly by adaptive self-organisation, underpinned by competing interests. Secondly, it was influenced by the relationship between systems, rather than simply being a product of issues within those systems. The relationship between the health system and the research system was weaker than might have been expected. Responsibilities were unclear, leading to confusion and delayed action. Conventional ways of thinking about organisations suggest that change happens when leaders and managers change the strategic vision, structure or procedures in an organisation and then persuade others to rationally implement the strategy. However, health research systems are complex adaptive systems characterised by high levels of unpredictability due to self-organisation and systemic interactions, which give rise to 'emergent' properties. We argue for the need to study how micro-processes of organisational dynamics may give rise to macro patterns of behaviour and strategic organisational direction and for the use of systems approaches to investigate the emergent properties of health research systems.

  14. Translationally invariant coupled cluster theory for simple finite systems

    Energy Technology Data Exchange (ETDEWEB)

    Bishop, R.F.; Flynn, M.F. (Department of Mathematics, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester M60 1QD (United Kingdom)); Bosca, M.C.; Buendriaaa, E.; Guardiola, R. (Departamento de Fisica Moderna, Universidad de Granada, Facultad de Ciencias, 18071 Granada (Spain))

    1990-10-01

    The widely used coupled cluster method (CCM) in quantum many-body theory has recently provided very accurate descriptions of a large number of extended systems. Although its earlier applications to closed-shell and neighboring finite nuclei were also very successful, they have been shrouded in algebraic and technical complexity. Furthermore, they are difficult to compare with more traditional calculations of generalized shell-model theory since, at least at the important level of two-body correlations, they have been largely implemented in relative-coordinate space rather than the more usual oscillator configuration space. The CCM is reviewed here in the precise context of applications to simple finite systems. Special attention is paid to formulate it in such a way that comparison may be made with generalized shell-model or configuration-interaction (CI) theories. Particular regard is paid to an exact incorporation of translational invariance, so that any spuriosity associated with the center-of-mass motion is always avoided. An important side benefit is that the number of many-body configurations in the usual oscillator basis is dramatically reduced. We are thereby able to present both CI and CCM calculations on {sup 4}He up to the essentially unprecedented level of 60{h bar}{omega} in oscillator excitation energy, for two popular and quasirealistic choices of the nucleon-nucleon interaction for which exact Monte Carlo results are available for this nucleus. Although even our simplest approximations attain about 95% of the total binding energy, the convergence in the oscillator configuration space is shown to be both very slow and of a complicated nonuniform nature. Strong implications are drawn for standard implementations of generalized shell-model techniques for heavier nuclei.

  15. Effect of contrasting crop rotation systems on soil chemical and biochemical properties and plant root growth in organic farming: First results

    OpenAIRE

    Elga Monaci; Serena Polverigiani; Davide Neri; Michele Bianchelli; Rodolfo Santilocchi; Marco Toderi; Paride D'Ottavio; Costantino Vischetti

    2017-01-01

    Organic farming is claimed to improve soil fertility. Nonetheless, among organic practices, net C-inputs may largely vary in amount and composition and produce different soil conditions for microbial activity and plant-root system adaptation and development. In this study, we hypothesised that, in the regime of organic agriculture, soil chemical and biochemical properties can substantially differ under contrasting crop rotation systems and produce conditions of soil fertility to which the pla...

  16. Developmental Systems of Students' Personal Theories about Education

    Science.gov (United States)

    Barger, Michael M.; Linnenbrink-Garcia, Lisa

    2017-01-01

    Children hold many personal theories about education: theories about themselves, knowledge, and the learning process. Personal theories help children predict what their actions will cause, and therefore relate to motivation, self-regulation, and achievement. Researchers typically examine how specific types of personal theories develop…

  17. A New Data Analysis System to Quantify Associations between Biochemical Parameters of Chronic Kidney Disease-Mineral Bone Disease.

    Directory of Open Access Journals (Sweden)

    Mariano Rodriguez

    Full Text Available In hemodialysis patients, deviations from KDIGO recommended values of individual parameters, phosphate, calcium or parathyroid hormone (PTH, are associated with increased mortality. However, it is widely accepted that these parameters are not regulated independently of each other and that therapy aimed to correct one parameter often modifies the others. The aim of the present study is to quantify the degree of association between parameters of chronic kidney disease and mineral bone disease (CKD-MBD.Data was extracted from a cohort of 1758 adult HD patients between January 2000 and June 2013 obtaining a total of 46.141 records (10 year follow-up. We used an advanced data analysis system called Random Forest (RF which is based on self-learning procedure with similar axioms to those utilized for the development of artificial intelligence. This new approach is particularly useful when the variables analyzed are closely dependent to each other.The analysis revealed a strong association between PTH and phosphate that was superior to that of PTH and Calcium. The classical linear regression analysis between PTH and phosphate shows a correlation coefficient is 0.27, p<0.001, the possibility to predict PTH changes from phosphate modification is marginal. Alternatively, RF assumes that changes in phosphate will cause modifications in other associated variables (calcium and others that may also affect PTH values. Using RF the correlation coefficient between changes in serum PTH and phosphate is 0.77, p<0.001; thus, the power of prediction is markedly increased. The effect of therapy on biochemical variables was also analyzed using this RF.Our results suggest that the analysis of the complex interactions between mineral metabolism parameters in CKD-MBD may demand a more advanced data analysis system such as RF.

  18. A flow injection analysis system with encapsulated high-density Saccharomyces cerevisiae cells for rapid determination of biochemical oxygen demand.

    Science.gov (United States)

    Seo, Kyo Seong; Choo, Kwang Ho; Chang, Ho Nam; Park, Joong Kon

    2009-05-01

    The biochemical oxygen demand (BOD) determination was studied using a novel flow injection analysis (FIA) system with encapsulated Saccharomyces cerevisiae cells and an oxygen electrode and was compared with conventional 5-day BOD tests. S. cerevisiae cells were packed in a calcium alginate capsule at a dry cell weight of 250 g/l of capsule core. The level of dissolved oxygen (DO) was reduced due to the enhanced respiratory activity of the microbial cells when the injected nutrient passed through the bioreactor. The decrease in DO (DeltaDO) was intensified with the amount of microbial cells packed in the bioreactor. However, the specific DeltaDO decreased as the amount of cells loaded in the bioreactor increased. The DeltaDO value was dependent on the pH and temperature of the mobile phase and reached its maximum value at 35 degrees C and pH 7-8. Also, DeltaDO became larger at longer response times as the flow rate of the mobile phase decreased. The measurement of DeltaDO was repeated more than six times consecutively using a 20-ppm standard glucose and glutamic acid solution, which confirmed the reproducibility with a standard deviation of 0.95%. A strong linear correlation between DeltaDO and BOD was also observed. The 5-day BOD values of actual water and wastewater samples were in accordance with the BOD values obtained by this FIA method using encapsulated S. cerevisiae cells. Unlike the cell-immobilized bead system, there was no contamination of the bioreactor resulting from any leak of yeast cells from the sensor capsules during BOD measurements.

  19. Complex adaptive systems and game theory: An unlikely union

    Science.gov (United States)

    Hadzikadic, M.; Carmichael, T.; Curtin, C.

    2010-01-01

    A Complex Adaptive System is a collection of autonomous, heterogeneous agents, whose behavior is defined with a limited number of rules. A Game Theory is a mathematical construct that assumes a small number of rational players who have a limited number of actions or strategies available to them. The CAS method has the potential to alleviate some of the shortcomings of GT. On the other hand, CAS researchers are always looking for a realistic way to define interactions among agents. GT offers an attractive option for defining the rules of such interactions in a way that is both potentially consistent with observed real-world behavior and subject to mathematical interpretation. This article reports on the results of an effort to build a CAS system that utilizes GT for determining the actions of individual agents. ?? 2009 Wiley Periodicals, Inc. Complexity, 16,24-42, 2010.

  20. Extending Molecular Theory to Steady-State Diffusing Systems

    Energy Technology Data Exchange (ETDEWEB)

    FRINK,LAURA J. D.; SALINGER,ANDREW G.; THOMPSON,AIDAN P.

    1999-10-22

    Predicting the properties of nonequilibrium systems from molecular simulations is a growing area of interest. One important class of problems involves steady state diffusion. To study these cases, a grand canonical molecular dynamics approach has been developed by Heffelfinger and van Swol [J. Chem. Phys., 101, 5274 (1994)]. With this method, the flux of particles, the chemical potential gradients, and density gradients can all be measured in the simulation. In this paper, we present a complementary approach that couples a nonlocal density functional theory (DFT) with a transport equation describing steady-state flux of the particles. We compare transport-DFT predictions to GCMD results for a variety of ideal (color diffusion), and nonideal (uphill diffusion and convective transport) systems. In all cases excellent agreement between transport-DFT and GCMD calculations is obtained with diffusion coefficients that are invariant with respect to density and external fields.

  1. What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated.

    Science.gov (United States)

    Kumaran, Dharshan; Hassabis, Demis; McClelland, James L

    2016-07-01

    We update complementary learning systems (CLS) theory, which holds that intelligent agents must possess two learning systems, instantiated in mammalians in neocortex and hippocampus. The first gradually acquires structured knowledge representations while the second quickly learns the specifics of individual experiences. We broaden the role of replay of hippocampal memories in the theory, noting that replay allows goal-dependent weighting of experience statistics. We also address recent challenges to the theory and extend it by showing that recurrent activation of hippocampal traces can support some forms of generalization and that neocortical learning can be rapid for information that is consistent with known structure. Finally, we note the relevance of the theory to the design of artificial intelligent agents, highlighting connections between neuroscience and machine learning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. An enactive and dynamical systems theory account of dyadic relationships.

    Science.gov (United States)

    Kyselo, Miriam; Tschacher, Wolfgang

    2014-01-01

    Many social relationships are a locus of struggle and suffering, either at the individual or interactional level. In this paper we explore why this is the case and suggest a modeling approach for dyadic interactions and the well-being of the participants. To this end we bring together an enactive approach to self with dynamical systems theory. Our basic assumption is that the quality of any social interaction or relationship fundamentally depends on the nature and constitution of the individuals engaged in these interactions. From an enactive perspective the self is conceived as an embodied and socially enacted autonomous system striving to maintain an identity. This striving involves a basic two-fold goal: the ability to exist as an individual in one's own right, while also being open to and affected by others. In terms of dynamical systems theory one can thus consider the individual self as a self-other organized system represented by a phase space spanned by the dimensions of distinction and participation, where attractors can be defined. Based on two everyday examples of dyadic relationship we propose a simple model of relationship dynamics, in which struggle or well-being in the dyad is analyzed in terms of movements of dyadic states that are in tension or in harmony with individually developed attractors. Our model predicts that relationships can be sustained when the dyad develops a new joint attractor toward which dyadic states tend to move, and well-being when this attractor is in balance with the individuals' attractors. We outline how this can inspire research on psychotherapy. The psychotherapy process itself provides a setting that supports clients to become aware how they fare with regards to the two-fold norm of distinction and participation and develop, through active engagement between client (or couple) and therapist, strategies to co-negotiate their self-organization.

  3. The health information system security threat lifecycle: an informatics theory.

    Science.gov (United States)

    Fernando, Juanita I; Dawson, Linda L

    2009-12-01

    This manuscript describes the health information system security threat lifecycle (HISSTL) theory. The theory is grounded in case study data analyzing clinicians' health information system (HIS) privacy and security (P&S) experiences in the practice context. The 'questerview' technique was applied to this study of 26 clinicians situated in 3 large Australian (across Victoria) teaching hospitals. Questerviews rely on data collection that apply standardized questions and questionnaires during recorded interviews. Analysis (using Nvivo) involved the iterative scrutiny of interview transcripts to identify emergent themes. Issues including poor training, ambiguous legal frameworks containing punitive threats, productivity challenges, usability errors and the limitations of the natural hospital environment emerged from empirical data about the clinicians' HIS P&S practices. The natural hospital environment is defined by the permanence of electronic HISs (e-HISs), shared workspaces, outdated HIT infrastructure, constant interruption, a P&S regulatory environment that is not conducive to optimal training outcomes and budgetary constraints. The evidence also indicated the obtrusiveness, timeliness, and reliability of P&S implementations for clinical work affected participant attitudes to, and use of, e-HISs. The HISSTL emerged from the analysis of study evidence. The theory embodies elements such as the fiscal, regulatory and natural hospital environments which impede P&S implementations in practice settings. These elements conflict with improved patient care outcomes. Efforts by clinicians to avoid conflict and emphasize patient care above P&S tended to manifest as security breaches. These breaches entrench factors beyond clinician control and perpetuate those within clinician control. Security breaches of health information can progress through the HISSTL. Some preliminary suggestions for addressing these issues are proposed. Legislative frameworks that are not related to

  4. Elements of social representation theory incollaborative tagging systems

    Directory of Open Access Journals (Sweden)

    Patricia Zeni Marchiori

    Full Text Available This article discusses the information representation process based on the Moscovici's Social Representation Theory and domain analysis in Information Science. The aim was to identify mechanisms and constituent dimensions of social representation in collaborative tagging systems/social bookmarking systems. Scientific knowledge was defined as the object/phenomenon of representation in these systems; and the tag as the shareable structure of meaning that connects participants and resources. The empirical research involved descriptive statistical techniques applied to a corpora of tags available in CiteULike, which is a social tagging system developed for the academic community. The data analysis, performed in a sample of groups derived from the dataset, showed that the users' reuse of their own tags resembles the anchorage mechanism. The reuse of tags by other participants - in the same group - reveals some evidence of the objectification mechanism. Some speculation arose about the cognitive effort made by the individual, under group influence, with regard to the tagging activity, user's choice of resources, and sharing styles. Further studies on social bookmarking systems depend both on a "gain scale" of users and items tagged, requiring techniques and procedures redesigned by Information Science, Statistics, Network Analysis, Linguistics/Sociolinguistics and Social Psychology.

  5. Evaluating accounting information systems that support multiple GAAP reporting using Normalized Systems Theory

    NARCIS (Netherlands)

    Vanhoof, E.; Huysmans, P.; Aerts, Walter; Verelst, J.; Aveiro, D.; Tribolet, J.; Gouveia, D.

    2014-01-01

    This paper uses a mixed methods approach of design science and case study research to evaluate structures of Accounting Information Systems (AIS) that report in multiple Generally Accepted Accounting Principles (GAAP), using Normalized Systems Theory (NST). To comply with regulation, many companies

  6. A non-extensive thermodynamic theory of ecological systems

    Science.gov (United States)

    Van Xuan, Le; Khac Ngoc, Nguyen; Lan, Nguyen Tri; Viet, Nguyen Ai

    2017-06-01

    After almost 30 years of development, it is not controversial issue that the so-called Tsallis entropy provides a useful approach to studying the complexity where the non-additivity of the systems under consideration is frequently met. Also, in the ecological research, Tsallis entropy, or in other words, q-entropy has been found itself as a generalized approach to define a range of diversity indices including Shannon-Wiener and Simpson indices. As a further stage of development in theoretical research, a thermodynamic theory based on Tsallis entropy or diversity indices in ecology has to be constructed for ecological systems to provide knowledge of ecological macroscopic behaviors. The standard method of theoretical physics is used in the manipulation and the equivalence between phenomenological thermodynamics and ecological aspects is the purpose of the ongoing research. The present work is in the line of the authors research to implement Tsallis non-extensivity approach to obtain the most important thermodynamic quantities of ecological systems such as internal energy Uq and temperature Tq based on a given modeled truncated Boltzmann distribution of the Whittaker plot for a dataset. These quantities have their own ecological meaning, especially the temperature Tq provides the insight of equilibrium condition among ecological systems as it is well-known in 0th law of thermodynamics.

  7. CALIBRATION OF EQUILIBRIUM TIDE THEORY FOR EXTRASOLAR PLANET SYSTEMS

    International Nuclear Information System (INIS)

    Hansen, Brad M. S.

    2010-01-01

    We provide an 'effective theory' of tidal dissipation in extrasolar planet systems by empirically calibrating a model for the equilibrium tide. The model is valid to high order in eccentricity and parameterized by two constants of bulk dissipation-one for dissipation in the planet and one for dissipation in the host star. We are able to consistently describe the distribution of extrasolar planetary systems in terms of period, eccentricity, and mass (with a lower limit of a Saturn mass) with this simple model. Our model is consistent with the survival of short-period exoplanet systems, but not with the circularization period of equal mass stellar binaries, suggesting that the latter systems experience a higher level of dissipation than exoplanet host stars. Our model is also not consistent with the explanation of inflated planetary radii as resulting from tidal dissipation. The paucity of short-period planets around evolved A stars is explained as the result of enhanced tidal inspiral resulting from the increase in stellar radius with evolution.

  8. Coarsening in Solid Liquid Systems: A Verification of Fundamental Theory

    Science.gov (United States)

    Thompson, John D.

    Coarsening is a process that occurs in nearly all multi-phase materials in which the total energy of a system is reduced through the reduction of total interfacial energy. The theoretical description of this process is of central importance to materials design, yet remains controversial. In order to directly compare experiment to theoretical predictions, low solid volume fraction PbSn alloys were coarsened in a microgravity environment aboard the International Space Station (ISS) as part of the Coarsening in Solid Liquid Mixtures (CSLM) project. PbSn samples with solid volume fractions of 15%, 20% and 30% were characterized in 2D and 3D using mechanical serial sectioning. The systems were observed in the self-similar regime predicted by theory and the particle size and particle density obeyed the temporal power laws predicted by theory. However, the magnitudes of the rate constants governing those temporal laws as well as the forms of the particle size distributions were not described well by theoretical predictions. Additionally, in the 30% solid volume fraction system, the higher volume fraction results in a non-spherical particle shape and a more closely packed spatial distribution. The presence of slow particle motion induced by vibrations on the ISS is presented as an explanation for this discrepancy. To model the effect of this particle motion, the Akaiwa-Voorhees multiparticle diffusion simulations are modified to treat coarsening in the presence of a small convection term, such as that of sedimentation, corresponding to low Peclet numbers. The simulations indicate that the particle size dependent velocity of the sedimentation increases the rate at which the system coarsens. This is due to the larger particles traveling farther than normal, resulting in them encountering more small particles, which favors their growth. Additionally, sedimentation resulted in broader PSDs with a peak located at the average particle size. When the simulations are modified to

  9. Multidimensional biochemical information processing of dynamical patterns.

    Science.gov (United States)

    Hasegawa, Yoshihiko

    2018-02-01

    Cells receive signaling molecules by receptors and relay information via sensory networks so that they can respond properly depending on the type of signal. Recent studies have shown that cells can extract multidimensional information from dynamical concentration patterns of signaling molecules. We herein study how biochemical systems can process multidimensional information embedded in dynamical patterns. We model the decoding networks by linear response functions, and optimize the functions with the calculus of variations to maximize the mutual information between patterns and output. We find that, when the noise intensity is lower, decoders with different linear response functions, i.e., distinct decoders, can extract much information. However, when the noise intensity is higher, distinct decoders do not provide the maximum amount of information. This indicates that, when transmitting information by dynamical patterns, embedding information in multiple patterns is not optimal when the noise intensity is very large. Furthermore, we explore the biochemical implementations of these decoders using control theory and demonstrate that these decoders can be implemented biochemically through the modification of cascade-type networks, which are prevalent in actual signaling pathways.

  10. Multidimensional biochemical information processing of dynamical patterns

    Science.gov (United States)

    Hasegawa, Yoshihiko

    2018-02-01

    Cells receive signaling molecules by receptors and relay information via sensory networks so that they can respond properly depending on the type of signal. Recent studies have shown that cells can extract multidimensional information from dynamical concentration patterns of signaling molecules. We herein study how biochemical systems can process multidimensional information embedded in dynamical patterns. We model the decoding networks by linear response functions, and optimize the functions with the calculus of variations to maximize the mutual information between patterns and output. We find that, when the noise intensity is lower, decoders with different linear response functions, i.e., distinct decoders, can extract much information. However, when the noise intensity is higher, distinct decoders do not provide the maximum amount of information. This indicates that, when transmitting information by dynamical patterns, embedding information in multiple patterns is not optimal when the noise intensity is very large. Furthermore, we explore the biochemical implementations of these decoders using control theory and demonstrate that these decoders can be implemented biochemically through the modification of cascade-type networks, which are prevalent in actual signaling pathways.

  11. Density functional theory and dynamical mean-field theory. A way to model strongly correlated systems

    International Nuclear Information System (INIS)

    Backes, Steffen

    2017-04-01

    The study of the electronic properties of correlated systems is a very diverse field and has lead to valuable insight into the physics of real materials. In these systems, the decisive factor that governs the physical properties is the ratio between the electronic kinetic energy, which promotes delocalization over the lattice, and the Coulomb interaction, which instead favours localized electronic states. Due to this competition, correlated electronic systems can show unique and interesting properties like the Metal-Insulator transition, diverse phase diagrams, strong temperature dependence and in general a high sensitivity to the environmental conditions. A theoretical description of these systems is not an easy task, since perturbative approaches that do not preserve the competition between the kinetic and interaction terms can only be applied in special limiting cases. One of the most famous approaches to obtain the electronic properties of a real material is the ab initio density functional theory (DFT) method. It allows one to obtain the ground state density of the system under investigation by mapping onto an effective non-interacting system that has to be found self-consistently. While being an exact theory, in practical implementations certain approximations have to be made to the exchange-correlation potential. The local density approximation (LDA), which approximates the exchange-correlation contribution to the total energy by that of a homogeneous electron gas with the corresponding density, has proven quite successful in many cases. Though, this approximation in general leads to an underestimation of electronic correlations and is not able to describe a metal-insulator transition due to electronic localization in the presence of strong Coulomb interaction. A different approach to the interacting electronic problem is the dynamical mean-field theory (DMFT), which is non-perturbative in the kinetic and interaction term but neglects all non

  12. Density functional theory and dynamical mean-field theory. A way to model strongly correlated systems

    Energy Technology Data Exchange (ETDEWEB)

    Backes, Steffen

    2017-04-15

    The study of the electronic properties of correlated systems is a very diverse field and has lead to valuable insight into the physics of real materials. In these systems, the decisive factor that governs the physical properties is the ratio between the electronic kinetic energy, which promotes delocalization over the lattice, and the Coulomb interaction, which instead favours localized electronic states. Due to this competition, correlated electronic systems can show unique and interesting properties like the Metal-Insulator transition, diverse phase diagrams, strong temperature dependence and in general a high sensitivity to the environmental conditions. A theoretical description of these systems is not an easy task, since perturbative approaches that do not preserve the competition between the kinetic and interaction terms can only be applied in special limiting cases. One of the most famous approaches to obtain the electronic properties of a real material is the ab initio density functional theory (DFT) method. It allows one to obtain the ground state density of the system under investigation by mapping onto an effective non-interacting system that has to be found self-consistently. While being an exact theory, in practical implementations certain approximations have to be made to the exchange-correlation potential. The local density approximation (LDA), which approximates the exchange-correlation contribution to the total energy by that of a homogeneous electron gas with the corresponding density, has proven quite successful in many cases. Though, this approximation in general leads to an underestimation of electronic correlations and is not able to describe a metal-insulator transition due to electronic localization in the presence of strong Coulomb interaction. A different approach to the interacting electronic problem is the dynamical mean-field theory (DMFT), which is non-perturbative in the kinetic and interaction term but neglects all non

  13. Current status of temporomandibular joint disorders and the therapeutic system derived from a series of biomechanical, histological, and biochemical studies

    Directory of Open Access Journals (Sweden)

    Kazuo Tanne

    2015-01-01

    Full Text Available This article was designed to report the current status of temporomandibular joint disorders (TMDs and the therapeutic system on the basis of a series of clinical, biomechanical, histological and biochemical studies in our research groups. In particular, we have focused on the association of degenerative changes of articular cartilage in the mandibular condyle and the resultant progressive condylar resorption with mechanical stimuli acting on the condyle during the stomatognathic function. In a clinical aspect, the nature and prevalence of TMDs, association of malocclusion with TMDs, association of condylar position with TMDs, association of craniofacial morphology with TMDs, and influences of TMDs, TMJ-osteoarthritis (TMJ-OA in particular, were examined. In a biomechanical aspect, the nature of stress distribution in the TMJ from maximum clenching was analyzed with finite element method. In addition, the pattern of stress distribution was examined in association with varying vertical discrepancies of the craniofacial skeleton and friction between the articular disk and condyle. The results demonstrated an induction of large compressive stresses in the anterior and lateral areas on the condyle by the maximum clenching and the subsequent prominent increases in the same areas of the mandibular condyle as the vertical skeletal discrepancy became more prominent. Increase of friction at the articular surface was also indicated as a cause of larger stresses and the relevant disk displacement, which further induced an increase in stresses in the tissues posterior to the disks, indicating an important role of TMJ disks as a stress absorber. In a histological or biological aspect, increase in TMJ loading simulated by vertical skeletal discrepancy, which has already been revealed by the preceding finite element analysis or represented by excessive mouth opening, produced a decrease in the thickness of cartilage layers, an increase in the numbers of

  14. Communication theory of quantum systems. Ph.D. Thesis, 1970

    Science.gov (United States)

    Yuen, H. P. H.

    1971-01-01

    Communication theory problems incorporating quantum effects for optical-frequency applications are discussed. Under suitable conditions, a unique quantum channel model corresponding to a given classical space-time varying linear random channel is established. A procedure is described by which a proper density-operator representation applicable to any receiver configuration can be constructed directly from the channel output field. Some examples illustrating the application of our methods to the development of optical quantum channel representations are given. Optimizations of communication system performance under different criteria are considered. In particular, certain necessary and sufficient conditions on the optimal detector in M-ary quantum signal detection are derived. Some examples are presented. Parameter estimation and channel capacity are discussed briefly.

  15. Constructal theory and flow architectures in living systems

    Directory of Open Access Journals (Sweden)

    Reis Antonio Heitor

    2006-01-01

    Full Text Available We apply Constructal theory to the study of the flow structure of the human respiratory tree. We show that the flow architecture that would per form oxygenation of the blood and removal of carbon dioxide best, i. e. with lowest resistance, would be composed of a channel system with 23 bifurcation with a diffusive zone (alveolus at the end. As this tree matches the human respiratory tree we conclude that nature has optimized it in time. Two constructal relation ships also emerge: (1 the length l, de fined by the ratio of the square of the airway diameter to its length, is constant for all individuals of the same species, and (2 the length γ is related to the volume of the space al located to the respiratory process, to the length of the respiratory tree and to the area of the alveoli, and determines univocally the branching level of the respiratory tree.

  16. The Power and Promise of Developmental Systems Theory

    Directory of Open Access Journals (Sweden)

    Letitia Meynell

    2008-09-01

    Full Text Available I argue that it is time for many feminists to rethink their attitudes towards evolutionary biology, not because feminists have been wrong to be deeply sceptical about many of its claims, both explicit and implicit, but because biology itself has changed. A new appreciation for the importance of development in biology has become mainstream and a new ontology, associated with developmental systems theory (DST, has been introduced over the last two decades. This turn challenges some of the features of evolutionary biology that have most troubled feminists. DST undermines the idea of biologicales sence and challenges both nature /nurture and nature/culture distinctions. Freed from these conceptual constraints, evolutionary biology no longer poses the problems that have justified feminist scepticism. Indeed, feminists have already found useful applications for DST and I argue that they should expand their use of DST to support more radical and wide-ranging political theories.Si les féministes n’ont pas eu tort d’être profondément sceptiques face aux nombreuses revendications de la biologie, leur attitude face à cette science doit être remise en question car la biologie s’est transformée au courant des dernières décennies. La «théorie des systèmes de développement» (developmental systems theory-TDS est une théorie qui s’est considérablement développée et qui a pris beaucoup d’ampleur. Cette théorie n’accepte pas le concept d’essence biologique ce qui pose un défi important à la distinction nature/culture. Une des conséquences de cet apport théorique est que le scepticisme des féministes face à la biologie de l’évolution n’est plus justifié car la biologie ne comporte plus les contraintes essentialistes qui s’avéraient contentieuses. En effet, certaines féministes ont déjà trouvé des applications utiles pour la TDS et nous avançons que les féministes doivent maintenant élargir l’utilisation de la

  17. The role of bioenergy and biochemicals in CO2 mitigation through the energy system - a scenario analysis for the Netherlands

    NARCIS (Netherlands)

    Tsiropoulos, Ioannis; Hoefnagels, Ric; van den Broek, Machteld; Patel, Martin K.; Faaij, Andre P.C.

    2017-01-01

    Bioenergy as well as bioenergy with carbon capture and storage are key options to embark on cost-efficient trajectories that realize climate targets. Most studies have not yet assessed the influence on these trajectories of emerging bioeconomy sectors such as biochemicals and renewable jet fuels

  18. Inverse problem studies of biochemical systems with structure identification of S-systems by embedding training functions in a genetic algorithm.

    Science.gov (United States)

    Sarode, Ketan Dinkar; Kumar, V Ravi; Kulkarni, B D

    2016-05-01

    An efficient inverse problem approach for parameter estimation, state and structure identification from dynamic data by embedding training functions in a genetic algorithm methodology (ETFGA) is proposed for nonlinear dynamical biosystems using S-system canonical models. Use of multiple shooting and decomposition approach as training functions has been shown for handling of noisy datasets and computational efficiency in studying the inverse problem. The advantages of the methodology are brought out systematically by studying it for three biochemical model systems of interest. By studying a small-scale gene regulatory system described by a S-system model, the first example demonstrates the use of ETFGA for the multifold aims of the inverse problem. The estimation of a large number of parameters with simultaneous state and network identification is shown by training a generalized S-system canonical model with noisy datasets. The results of this study bring out the superior performance of ETFGA on comparison with other metaheuristic approaches. The second example studies the regulation of cAMP oscillations in Dictyostelium cells now assuming limited availability of noisy data. Here, flexibility of the approach to incorporate partial system information in the identification process is shown and its effect on accuracy and predictive ability of the estimated model are studied. The third example studies the phenomenological toy model of the regulation of circadian oscillations in Drosophila that follows rate laws different from S-system power-law. For the limited noisy data, using a priori information about properties of the system, we could estimate an alternate S-system model that showed robust oscillatory behavior with predictive abilities. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Numerical perturbative methods in the quantum theory of physical systems

    International Nuclear Information System (INIS)

    Adam, G.

    1980-01-01

    During the last two decades, development of digital electronic computers has led to the deployment of new, distinct methods in theoretical physics. These methods, based on the advances of modern numerical analysis as well as on specific equations describing physical processes, enabled to perform precise calculations of high complexity which have completed and sometimes changed our image of many physical phenomena. Our efforts have concentrated on the development of numerical methods with such intrinsic performances as to allow a successful approach of some Key issues in present theoretical physics on smaller computation systems. The basic principle of such methods is to translate, in numerical analysis language, the theory of perturbations which is suited to numerical rather than to analytical computation. This idea has been illustrated by working out two problems which arise from the time independent Schroedinger equation in the non-relativistic approximation, within both quantum systems with a small number of particles and systems with a large number of particles, respectively. In the first case, we are led to the numerical solution of some quadratic ordinary differential equations (first section of the thesis) and in the second case, to the solution of some secular equations in the Brillouin area (second section). (author)

  20. Artificial Intelligence and Systems Theory: Applied to Cooperative Robots

    Directory of Open Access Journals (Sweden)

    Pedro U. Lima

    2004-09-01

    Full Text Available This paper describes an approach to the design of a population of cooperative robots based on concepts borrowed from Systems Theory and Artificial Intelligence. The research has been developed under the SocRob project, carried out by the Intelligent Systems Laboratory at the Institute for Systems and Robotics - Instituto Superior Técnico (ISR/IST in Lisbon. The acronym of the project stands both for “Society of Robots” and “Soccer Robots”, the case study where we are testing our population of robots. Designing soccer robots is a very challenging problem, where the robots must act not only to shoot a ball towards the goal, but also to detect and avoid static (walls, stopped robots and dynamic (moving robots obstacles. Furthermore, they must cooperate to defeat an opposing team. Our past and current research in soccer robotics includes cooperative sensor fusion for world modeling, object recognition and tracking, robot navigation, multi-robot distributed task planning and coordination, including cooperative reinforcement learning in cooperative and adversarial environments, and behavior-based architectures for real time task execution of cooperating robot teams.

  1. Artificial Intelligence and Systems Theory: Applied to Cooperative Robots

    Directory of Open Access Journals (Sweden)

    Pedro U. Lima

    2008-11-01

    Full Text Available This paper describes an approach to the design of a population of cooperative robots based on concepts borrowed from Systems Theory and Artificial Intelligence. The research has been developed under the SocRob project, carried out by the Intelligent Systems Laboratory at the Institute for Systems and Robotics - Instituto Superior T?cnico (ISR/IST in Lisbon. The acronym of the project stands both for "Society of Robots" and "Soccer Robots", the case study where we are testing our population of robots. Designing soccer robots is a very challenging problem, where the robots must act not only to shoot a ball towards the goal, but also to detect and avoid static (walls, stopped robots and dynamic (moving robots obstacles. Furthermore, they must cooperate to defeat an opposing team. Our past and current research in soccer robotics includes cooperative sensor fusion for world modeling, object recognition and tracking, robot navigation, multi-robot distributed task planning and coordination, including cooperative reinforcement learning in cooperative and adversarial environments, and behavior-based architectures for real time task execution of cooperating robot teams.

  2. Cognitive performance modeling based on general systems performance theory.

    Science.gov (United States)

    Kondraske, George V

    2010-01-01

    General Systems Performance Theory (GSPT) was initially motivated by problems associated with quantifying different aspects of human performance. It has proved to be invaluable for measurement development and understanding quantitative relationships between human subsystem capacities and performance in complex tasks. It is now desired to bring focus to the application of GSPT to modeling of cognitive system performance. Previous studies involving two complex tasks (i.e., driving and performing laparoscopic surgery) and incorporating measures that are clearly related to cognitive performance (information processing speed and short-term memory capacity) were revisited. A GSPT-derived method of task analysis and performance prediction termed Nonlinear Causal Resource Analysis (NCRA) was employed to determine the demand on basic cognitive performance resources required to support different levels of complex task performance. This approach is presented as a means to determine a cognitive workload profile and the subsequent computation of a single number measure of cognitive workload (CW). Computation of CW may be a viable alternative to measuring it. Various possible "more basic" performance resources that contribute to cognitive system performance are discussed. It is concluded from this preliminary exploration that a GSPT-based approach can contribute to defining cognitive performance models that are useful for both individual subjects and specific groups (e.g., military pilots).

  3. Using Organizational Systems Theory to Improve Defense Acquisition and Warfighter Requirements

    National Research Council Canada - National Science Library

    Alexander, Michael J

    2007-01-01

    .... Hence, this MBA study employed a systems approach to more credibly pinpoint improvement areas in the Defense Acquisition System through the use of systems theory and an organizational systems model...

  4. Lyapunov analysis: from dynamical systems theory to applications

    Science.gov (United States)

    Cencini, Massimo; Ginelli, Francesco

    2013-06-01

    [17], von Neumann [18], Krylov [19]3 and Asonov and Sinai [20] on ergodic theory. Lyapunov exponents quantify exponential sensitivity to initial conditions and provide direct access to the entropy production in ergodic systems via the Pesin theory [21]. Further advances have been made possible by the introduction of proper physical invariant measures for certain dissipative systems due to Sinai [22], Ruelle [23] and Bowen [24, 25]. However, it was necessary to wait until the end of the 1970s before the independent works of Shimada and Nagashima [26] and Benettin et al [27] introduced the numerical algorithms required to compute Lyapunov exponents beyond the largest one. The availability of such algorithms and also, at about the same time, of those necessary for the computation of fractal dimensions and entropies by Grassberger and Procaccia [28], made possible the study of chaotic behavior in physically relevant models. Lyapunov analysis, applied to experimental systems [29], was also made possible by a combination of these numerical methods with ideas from nonlinear time series analysis [30]. As a result, it is nowadays widely recognized that Lyapunov exponents are a central tool of chaos theory, crucial for characterizing a number of interesting physical properties including dynamical entropies and fractal dimensions [31]. Their pivotal role in modern dynamical systems theory has been established by a fruitful exchange between a rigorous (and beautiful) mathematical theory and the algorithmic approaches essential for understanding many physical phenomena. From the 1990s to the present, with the concomitant progress in both theoretical understanding and computer capabilities, there has been a progressive shift of interest from low dimensional towards high dimensional systems. This shift towards dynamics characterized by many degrees of freedom, possibly spatially organized and/or with several characteristic temporal scales, has been accompanied by the need for

  5. Principles of General Systems Theory: Some Implications for Higher Education Administration

    Science.gov (United States)

    Gilliland, Martha W.; Gilliland, J. Richard

    1978-01-01

    Three principles of general systems theory are presented and systems theory is distinguished from systems analysis. The principles state that all systems tend to become more disorderly, that they must be diverse in order to be stable, and that only those maximizing their resource utilization for doing useful work will survive. (Author/LBH)

  6. BOOK REVIEW: Theory of Neural Information Processing Systems

    Science.gov (United States)

    Galla, Tobias

    2006-04-01

    It is difficult not to be amazed by the ability of the human brain to process, to structure and to memorize information. Even by the toughest standards the behaviour of this network of about 1011 neurons qualifies as complex, and both the scientific community and the public take great interest in the growing field of neuroscience. The scientific endeavour to learn more about the function of the brain as an information processing system is here a truly interdisciplinary one, with important contributions from biology, computer science, physics, engineering and mathematics as the authors quite rightly point out in the introduction of their book. The role of the theoretical disciplines here is to provide mathematical models of information processing systems and the tools to study them. These models and tools are at the centre of the material covered in the book by Coolen, Kühn and Sollich. The book is divided into five parts, providing basic introductory material on neural network models as well as the details of advanced techniques to study them. A mathematical appendix complements the main text. The range of topics is extremely broad, still the presentation is concise and the book well arranged. To stress the breadth of the book let me just mention a few keywords here: the material ranges from the basics of perceptrons and recurrent network architectures to more advanced aspects such as Bayesian learning and support vector machines; Shannon's theory of information and the definition of entropy are discussed, and a chapter on Amari's information geometry is not missing either. Finally the statistical mechanics chapters cover Gardner theory and the replica analysis of the Hopfield model, not without being preceded by a brief introduction of the basic concepts of equilibrium statistical physics. The book also contains a part on effective theories of the macroscopic dynamics of neural networks. Many dynamical aspects of neural networks are usually hard to find in the

  7. Emergent nested systems a theory of understanding and influencing complex systems as well as case studies in urban systems

    CERN Document Server

    Walloth, Christian

    2016-01-01

    This book presents a theory as well as methods to understand and to purposively influence complex systems. It suggests a theory of complex systems as nested systems, i. e. systems that enclose other systems and that are simultaneously enclosed by even other systems. According to the theory presented, each enclosing system emerges through time from the generative activities of the systems they enclose. Systems are nested and often emerge unplanned, and every system of high dynamics is enclosed by a system of slower dynamics. An understanding of systems with faster dynamics, which are always guided by systems of slower dynamics, opens up not only new ways to understanding systems, but also to effectively influence them. The aim and subject of this book is to lay out these thoughts and explain their relevance to the purposive development of complex systems, which are exemplified in case studies from an urban system. The interested reader, who is not required to be familiar with system-theoretical concepts or wit...

  8. A theory of nonequilibrium steady states in quantum chaotic systems

    Science.gov (United States)

    Wang, Pei

    2017-09-01

    Nonequilibrium steady state (NESS) is a quasistationary state, in which exist currents that continuously produce entropy, but the local observables are stationary everywhere. We propose a theory of NESS under the framework of quantum chaos. In an isolated quantum system whose density matrix follows a unitary evolution, there exist initial states for which the thermodynamic limit and the long-time limit are noncommutative. The density matrix \\hat ρ of these states displays a universal structure. Suppose that \\renewcommand{\\ket}[1]{{\\vert #1 >}} \\ketα and \\renewcommand{\\ket}[1]{{\\vert #1 >}} \\ketβ are different eigenstates of the Hamiltonian with energies E_α and E_β , respectively. \\renewcommand{\\bra}[1]{} \\braα\\hat ρ \\ketβ behaves as a random number which has zero mean. In thermodynamic limit, the variance of \\renewcommand{\\bra}[1]{} \\braα\\hat ρ \\ketβ is a smooth function of ≤ft\\vert E_α-E_β\\right\\vert , scaling as 1/≤ft\\vert E_α-E_β\\right\\vert 2 in the limit ≤ft\\vert E_α-E_β\\right\\vert \\to 0 . If and only if this scaling law is obeyed, the initial state evolves into NESS in the long time limit. We present numerical evidence of our hypothesis in a few chaotic models. Furthermore, we find that our hypothesis indicates the eigenstate thermalization hypothesis (ETH) for current operators in a bipartite system.

  9. Switching theory-based steganographic system for JPEG images

    Science.gov (United States)

    Cherukuri, Ravindranath C.; Agaian, Sos S.

    2007-04-01

    Cellular communications constitute a significant portion of the global telecommunications market. Therefore, the need for secured communication over a mobile platform has increased exponentially. Steganography is an art of hiding critical data into an innocuous signal, which provide answers to the above needs. The JPEG is one of commonly used format for storing and transmitting images on the web. In addition, the pictures captured using mobile cameras are in mostly in JPEG format. In this article, we introduce a switching theory based steganographic system for JPEG images which is applicable for mobile and computer platforms. The proposed algorithm uses the fact that energy distribution among the quantized AC coefficients varies from block to block and coefficient to coefficient. Existing approaches are effective with a part of these coefficients but when employed over all the coefficients they show there ineffectiveness. Therefore, we propose an approach that works each set of AC coefficients with different frame work thus enhancing the performance of the approach. The proposed system offers a high capacity and embedding efficiency simultaneously withstanding to simple statistical attacks. In addition, the embedded information could be retrieved without prior knowledge of the cover image. Based on simulation results, the proposed method demonstrates an improved embedding capacity over existing algorithms while maintaining a high embedding efficiency and preserving the statistics of the JPEG image after hiding information.

  10. System of marketing deciding support based on game theory

    Directory of Open Access Journals (Sweden)

    Gordana Dukić

    2008-12-01

    Full Text Available Quantitative methods and models can be applied in numerous spheres of marketing deciding. The choice of optimal strategy in product advertising is one of the problems that the marketing-management often meets. The use of models developed within the framework of game theory makes significantly easier to find out the solutions of conflict situations that appear herewith. The system of deciding support presented in this work is based on the supposition that two opposed sides take part in the game. With the aim of deciding process promotion, the starting model incorporates computer simulation of percentile changes in the market share that represent elements of payment matrix. The supposition is that the random variables that represent them follow the normal division. It is necessary to carry out the evaluation of their parameters because of relevant data. Information techniques, computer and the adequate program applications take the special position in solving and analysis of the suggested model. This kind of their application represents the basic characteristic of the deciding support system.

  11. Recent trends in social systems quantitative theories and quantitative models

    CERN Document Server

    Hošková-Mayerová, Šárka; Soitu, Daniela-Tatiana; Kacprzyk, Janusz

    2017-01-01

    The papers collected in this volume focus on new perspectives on individuals, society, and science, specifically in the field of socio-economic systems. The book is the result of a scientific collaboration among experts from “Alexandru Ioan Cuza” University of Iaşi (Romania), “G. d’Annunzio” University of Chieti-Pescara (Italy), "University of Defence" of Brno (Czech Republic), and "Pablo de Olavide" University of Sevilla (Spain). The heterogeneity of the contributions presented in this volume reflects the variety and complexity of social phenomena. The book is divided in four Sections as follows. The first Section deals with recent trends in social decisions. Specifically, it aims to understand which are the driving forces of social decisions. The second Section focuses on the social and public sphere. Indeed, it is oriented on recent developments in social systems and control. Trends in quantitative theories and models are described in Section 3, where many new formal, mathematical-statistical to...

  12. Systems of Conditional Beliefs in Dempster-Shafer Theory and Expert Systems

    Czech Academy of Sciences Publication Activity Database

    Hájek, Petr

    1993-01-01

    Roč. 22, č. 2 (1993), s. 113-124 ISSN 0308-1079 R&D Projects: GA AV ČR IAA130108 Keywords : expert systems * Dempster-Shafer theory * conditioning * belief functions Impact factor: 0.293, year: 1993

  13. Density functional theory for polymeric systems in 2D.

    Science.gov (United States)

    Słyk, Edyta; Roth, Roland; Bryk, Paweł

    2016-06-22

    We propose density functional theory for polymeric fluids in two dimensions. The approach is based on Wertheim's first order thermodynamic perturbation theory (TPT) and closely follows density functional theory for polymers proposed by Yu and Wu (2002 J. Chem. Phys. 117 2368). As a simple application we evaluate the density profiles of tangent hard-disk polymers at hard walls. The theoretical predictions are compared against the results of the Monte Carlo simulations. We find that for short chain lengths the theoretical density profiles are in an excellent agreement with the Monte Carlo data. The agreement is less satisfactory for longer chains. The performance of the theory can be improved by recasting the approach using the self-consistent field theory formalism. When the self-avoiding chain statistics is used, the theory yields a marked improvement in the low density limit. Further improvements for long chains could be reached by going beyond the first order of TPT.

  14. Hitchin systems, N=2 gauge theories and W-gravity

    Energy Technology Data Exchange (ETDEWEB)

    Bonelli, Giulio, E-mail: bonelli@sissa.i [SISSA via Bonomea, 365 - 34136 Trieste, and INFN, Sezione di Trieste (Italy); Tanzini, Alessandro [SISSA via Bonomea, 365 - 34136 Trieste, and INFN, Sezione di Trieste (Italy)

    2010-07-19

    We propose some arguments supporting an M-theory derivation of the duality recently discovered by Alday, Gaiotto and Tachikawa between two-dimensional conformal field theories and N=2 superconformal gauge theories in four dimensions. We find that A{sub N-1} Toda field theory is the simplest two-dimensional conformal field theory quantizing the moduli of N M5-branes wrapped on a Riemann surface. This leads us to identify chiral operators of the N=2 gauge theories with integrated W-algebra currents. As a check of this correspondence we study some relevant OPE's obtaining that Nekrasov's partition function satisfies W-geometry constraints.

  15. Gravitation theory - Empirical status from solar system experiments.

    Science.gov (United States)

    Nordtvedt, K. L., Jr.

    1972-01-01

    Review of historical and recent experiments which speak in favor of a post-Newtonian relativistic gravitational theory. The topics include the foundational experiments, metric theories of gravity, experiments designed to differentiate among the metric theories, and tests of Machian concepts of gravity. It is shown that the metric field for any metric theory can be specified by a series of potential terms with several parameters. It is pointed out that empirical results available up to date yield values of the parameters which are consistent with the prediction of Einstein's general relativity.

  16. Developing Dynamic Field Theory Architectures for Embodied Cognitive Systems withcedar.

    Science.gov (United States)

    Lomp, Oliver; Richter, Mathis; Zibner, Stephan K U; Schöner, Gregor

    2016-01-01

    Embodied artificial cognitive systems, such as autonomous robots or intelligent observers, connect cognitive processes to sensory and effector systems in real time. Prime candidates for such embodied intelligence are neurally inspired architectures. While components such as forward neural networks are well established, designing pervasively autonomous neural architectures remains a challenge. This includes the problem of tuning the parameters of such architectures so that they deliver specified functionality under variable environmental conditions and retain these functions as the architectures are expanded. The scaling and autonomy problems are solved, in part, by dynamic field theory (DFT), a theoretical framework for the neural grounding of sensorimotor and cognitive processes. In this paper, we address how to efficiently build DFT architectures that control embodied agents and how to tune their parameters so that the desired cognitive functions emerge while such agents are situated in real environments. In DFT architectures, dynamic neural fields or nodes are assigned dynamic regimes, that is, attractor states and their instabilities, from which cognitive function emerges. Tuning thus amounts to determining values of the dynamic parameters for which the components of a DFT architecture are in the specified dynamic regime under the appropriate environmental conditions. The process of tuning is facilitated by the software framework cedar , which provides a graphical interface to build and execute DFT architectures. It enables to change dynamic parameters online and visualize the activation states of any component while the agent is receiving sensory inputs in real time. Using a simple example, we take the reader through the workflow of conceiving of DFT architectures, implementing them on embodied agents, tuning their parameters, and assessing performance while the system is coupled to real sensory inputs.

  17. Information theory as a general language for functional systems

    Science.gov (United States)

    Collier, John

    2000-05-01

    Function refers to a broad family of concepts of varying abstractness and range of application, from a many-one mathematical relation of great generality to, for example, highly specialized roles of designed elements in complex machines such as degaussing in a television set, or contributory processes to control mechanisms in complex metabolic pathways, such as the inhibitory function of the appropriate part of the lac-operon on the production of lactase through its action on the genome in the absence of lactose. We would like a language broad enough, neutral enough, but yet powerful enough to cover all such cases, and at the same time to give a framework form explanation both of the family resemblances and differences. General logic and mathematics are too abstract, but more importantly, too broad, whereas other discourses of function, such as the biological and teleological contexts, are too narrow. Information is especially suited since it is mathematically grounded, but also has a well-known physical interpretation through the Schrodinger/Brillouin Negentropy. Principle of Information, and an engineering or design interpretation through Shannon's communication theory. My main focus will be on the functions of autonomous anticipatory systems, but I will try to demonstrate both the connections between this notion of function and the others, especially to dynamical systems with a physical interpretation on the one side and intentional systems on the other. The former are based in concepts like force, energy and work, while the latter involve notions like representation, control and purpose, traditionally, at least in Modern times, on opposite sides of the Cartesian divide. In principle, information can be reduced to energy, but it has the advantage of being more flexible, and easier to apply to higher level phenomena.

  18. String Theory, Strongly Correlated Systems, and Duality Twists

    Science.gov (United States)

    Torres Chicon, Nesty Ray

    In the first part of this dissertation (Chapter 1), I present a construction of a six dimensional (2,0)-theory model that describes the dynamics of the Fractional Quantum Hall Effect (FQHE). The FQHE appears as part of the low energy description of the Coulomb branch of the A1 (2,0)-theory formulated on a geometry (S 1 x R2)/Zk. At low-energy, the configuration is described in terms of a 4+1D supersymmetric Yang-Mills (SYM) theory on a cone (R2/Z k) with additional 2+1D degrees of freedom at the tip of the cone that include fractionally charged particles. These fractionally charged "quasi-particles" are BPS strings of the (2,0)-theory wrapped on short cycles. In this framework, a W-boson can be modeled as a bound state of k quasi-particles, which can be used to understand the dynamics of the FQHE. In the second part of this dissertation (Chapters 2-3), I investigate the N=4 SYM theory compactified on a circle, with a varying coupling constant (Janus configuration) and an S-duality twist. I relate this setup to a three dimensional topological theory and to a dual string theory. The equality of these descriptions is exhibited by matching the operator algebra, and the dimensions of the Hilbert space. Additionally, this dissertation addresses a classic result in number theory, called quadratic reciprocity, using string theory language. I present a proof that quadratic reciprocity is a direct consequence of T-duality of Type-II string theory. This is demonstrated by analyzing a partition function of abelian N=4 SYM theory on a certain supersymmetry-preserving four-manifold with variable coupling constant and a SL(2,Z)-duality twist.

  19. Causal Fermion Systems as a Candidate for a Unified Physical Theory

    OpenAIRE

    Finster, Felix; Kleiner, Johannes

    2015-01-01

    The theory of causal fermion systems is an approach to describe fundamental physics. Giving quantum mechanics, general relativity and quantum field theory as limiting cases, it is a candidate for a unified physical theory. We here give a non-technical introduction.

  20. Untangling the drivers of nonlinear systems with information theory

    Science.gov (United States)

    Wing, S.; Johnson, J.

    2017-12-01

    Many systems found in nature are nonlinear. The drivers of the system are often nonlinearly correlated with one another, which makes it a challenge to understand the effects of an individual driver. For example, solar wind velocity (Vsw) and density (nsw) are both found to correlate well with radiation belt fluxes and are thought to be drivers of the magnetospheric dynamics; however, the Vsw is anti-correlated with nsw, which can potentially confuse interpretation of these relationships as causal or coincidental. Information theory can untangle the drivers of these systems, describe the underlying dynamics, and offer constraints to modelers and theorists, leading to better understanding of the systems. Two examples are presented. In the first example, the solar wind drivers of geosynchronous electrons with energy range of 1.8-3.5 MeV are investigated using mutual information (MI), conditional mutual information (CMI), and transfer entropy (TE). The information transfer from Vsw to geosynchronous MeV electron flux (Je) peaks with a lag time (t) of 2 days. As previously reported, Je is anticorrelated with nsw with a lag of 1 day. However, this lag time and anticorrelation can be attributed mainly to the Je(t + 2 days) correlation with Vsw(t) and nsw(t + 1 day) anticorrelation with Vsw(t). Analyses of solar wind driving of the magnetosphere need to consider the large lag times, up to 3 days, in the (Vsw, nsw) anticorrelation. Using CMI to remove the effects of Vsw, the response of Je to nsw is 30% smaller and has a lag time operating in system dynamics are investigated using windowed TE. When the data is ordered according to high or low transfer entropy it is possible to understand details of the triangle distribution that has been identified between Je(t + 2 days) vs. Vsw(t). In the second example, the previously identified causal parameters of the solar cycle such as the solar polar field, meridional flow, polar faculae (proxy for polar field), dipole axis strength

  1. Solar system constraints on multifield theories of modified dynamics

    NARCIS (Netherlands)

    Sanders, R. H.

    2006-01-01

    Any viable theory of modified Newtonian dynamics (MOND) as modified gravity is likely to require fields in addition to the usual tensor field of General Relativity. For these theories, the MOND phenomenology emerges as an effective fifth force probably associated with a scalar field. Here, I

  2. Dissipative open systems theory as a foundation for the thermodynamics of linear systems.

    Science.gov (United States)

    Delvenne, Jean-Charles; Sandberg, Henrik

    2017-03-06

    In this paper, we advocate the use of open dynamical systems, i.e. systems sharing input and output variables with their environment, and the dissipativity theory initiated by Jan Willems as models of thermodynamical systems, at the microscopic and macroscopic level alike. We take linear systems as a study case, where we show how to derive a global Lyapunov function to analyse networks of interconnected systems. We define a suitable notion of dynamic non-equilibrium temperature that allows us to derive a discrete Fourier law ruling the exchange of heat between lumped, discrete-space systems, enriched with the Maxwell-Cattaneo correction. We complete these results by a brief recall of the steps that allow complete derivation of the dissipation and fluctuation in macroscopic systems (i.e. at the level of probability distributions) from lossless and deterministic systems.This article is part of the themed issue 'Horizons of cybernetical physics'. © 2017 The Author(s).

  3. Applied Systemic Theory and Educational Psychology: Can the Twain Ever Meet?

    Science.gov (United States)

    Pellegrini, Dario W.

    2009-01-01

    This article reflects on the potential benefits of applying systemic theory to the work of educational psychologists (EPs). It reviews developments in systemic thinking over time, and discusses the differences between more directive "first order" versus collaborative "second order" approaches. It considers systemic theories and…

  4. General System Theory: Toward a Conceptual Framework for Science and Technology Education for All.

    Science.gov (United States)

    Chen, David; Stroup, Walter

    1993-01-01

    Suggests using general system theory as a unifying theoretical framework for science and technology education for all. Five reasons are articulated: the multidisciplinary nature of systems theory, the ability to engage complexity, the capacity to describe system dynamics, the ability to represent the relationship between microlevel and…

  5. Designing sociotechnical systems with cognitive work analysis: putting theory back into practice.

    Science.gov (United States)

    Read, Gemma J M; Salmon, Paul M; Lenné, Michael G; Stanton, Neville A

    2015-01-01

    Cognitive work analysis (CWA) is a framework of methods for analysing complex sociotechnical systems. However, the translation from the outputs of CWA to design is not straightforward. Sociotechnical systems theory provides values and principles for the design of sociotechnical systems which may offer a theoretically consistent basis for a design approach for use with CWA. This article explores the extent to which CWA and sociotechnical systems theory offer complementary perspectives and presents an abstraction hierarchy (AH), based on a review of literature, that describes an 'optimal' CWA and sociotechnical systems theory design system. The optimal AH is used to assess the extent to which current CWA-based design practices, uncovered through a survey of CWA practitioners, aligns with sociotechnical systems theory. Recommendations for a design approach that would support the integration of CWA and sociotechnical systems theory design values and principles are also derived.

  6. New Concepts and Theories For Intelligent Control of Cellular Manufacturing Systems

    DEFF Research Database (Denmark)

    Langer, Gilad

    1996-01-01

    This paper will present some new theories such as biological manufacturing system, the fractal factory theory, holonic manufacturing systems, agile manufacturing, object orientation, multi-agent theory, artificial intelligence, and artificial life in the context of manufacturing systems....... The objective of the paper is to show how these theories can contribute to develop the new concepts that are required for controlling the manufacturing systems of the future. Thereafter it will present the potential for improvement of the manufacturing system by introduction and implementation of these theories....... The paper tries to encapsulate the main area of my Ph.D. thesis research which will evolve around the idea of integrating intelligent elements into the control systems of the manufacturing systems. Furthermore it intends to show how the curriculum and discussions of the IPS Ph.D. course will and have...

  7. Calculation of local excitations in large systems by embedding wave-function theory in density-functional theory

    NARCIS (Netherlands)

    Gomes, A.S.P.; Jacob, C.R.; Visscher, L.

    2008-01-01

    We present a simple and efficient embedding scheme for the wave-function based calculation of the energies of local excitations in large systems. By introducing an embedding potential obtained from density-functional theory (DFT) it is possible to describe the effect of an environment on local

  8. The Construction of Higher Education Entrepreneur Services Network System a Research Based on Ecological Systems Theory

    Science.gov (United States)

    Xue, Jingxin

    The article aims to completely, systematically and objectively analyze the current situation of Entrepreneurship Education in China with Ecological Systems Theory. From this perspective, the author discusses the structure, function and its basic features of higher education entrepreneur services network system, and puts forward the opinion that every entrepreneurship organization in higher education institution does not limited to only one platform. Different functional supporting platforms should be combined closed through composite functional organization to form an integrated network system, in which each unit would impels others' development.

  9. Cancer Theory from Systems Biology Point of View

    Science.gov (United States)

    Wang, Gaowei; Tang, Ying; Yuan, Ruoshi; Ao, Ping

    In our previous work, we have proposed a novel cancer theory, endogenous network theory, to understand mechanism underlying cancer genesis and development. Recently, we apply this theory to hepatocellular carcinoma (HCC). A core endogenous network of hepatocyte was established by integrating the current understanding of hepatocyte at molecular level. Quantitative description of the endogenous network consisted of a set of stochastic differential equations which could generate many local attractors with obvious or non-obvious biological functions. By comparing with clinical observation and experimental data, the results showed that two robust attractors from the model reproduced the main known features of normal hepatocyte and cancerous hepatocyte respectively at both modular and molecular level. In light of our theory, the genesis and progression of cancer is viewed as transition from normal attractor to HCC attractor. A set of new insights on understanding cancer genesis and progression, and on strategies for cancer prevention, cure, and care were provided.

  10. Modeling Reusable and Interoperable Faceted Browsing Systems with Category Theory

    OpenAIRE

    Harris, Daniel R.

    2015-01-01

    Faceted browsing has become ubiquitous with modern digital libraries and online search engines, yet the process is still difficult to abstractly model in a manner that supports the development of interoperable and reusable interfaces. We propose category theory as a theoretical foundation for faceted browsing and demonstrate how the interactive process can be mathematically abstracted. Existing efforts in facet modeling are based upon set theory, formal concept analysis, and lightweight ontol...

  11. Transport through correlated systems with density functional theory.

    Science.gov (United States)

    Kurth, S; Stefanucci, G

    2017-10-18

    We present recent advances in density functional theory (DFT) for applications in the field of quantum transport, with particular emphasis on transport through strongly correlated systems. We review the foundations of the popular Landauer-Büttiker(LB)  +  DFT approach. This formalism, when using approximations to the exchange-correlation (xc) potential with steps at integer occupation, correctly captures the Kondo plateau in the zero bias conductance at zero temperature but completely fails to capture the transition to the Coulomb blockade (CB) regime as the temperature increases. To overcome the limitations of LB  +  DFT, the quantum transport problem is treated from a time-dependent (TD) perspective using TDDFT, an exact framework to deal with nonequilibrium situations. The steady-state limit of TDDFT shows that in addition to an xc potential in the junction, there also exists an xc correction to the applied bias. Open shell molecules in the CB regime provide the most striking examples of the importance of the xc bias correction. Using the Anderson model as guidance we estimate these corrections in the limit of zero bias. For the general case we put forward a steady-state DFT which is based on one-to-one correspondence between the pair of basic variables, steady density on and steady current across the junction and the pair local potential on and bias across the junction. Like TDDFT, this framework also leads to both an xc potential in the junction and an xc correction to the bias. Unlike TDDFT, these potentials are independent of history. We highlight the universal features of both xc potential and xc bias corrections for junctions in the CB regime and provide an accurate parametrization for the Anderson model at arbitrary temperatures and interaction strengths, thus providing a unified DFT description for both Kondo and CB regimes and the transition between them.

  12. A stochastic perturbation theory for non-autonomous systems

    Energy Technology Data Exchange (ETDEWEB)

    Moon, W., E-mail: wm275@damtp.cam.ac.uk [Yale University, New Haven, Connecticut 06520-8109 (United States); Wettlaufer, J. S., E-mail: wettlaufer@maths.ox.ac.uk [Yale University, New Haven, Connecticut 06520-8109 (United States); Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom)

    2013-12-15

    We develop a perturbation theory for a class of first order nonlinear non-autonomous stochastic ordinary differential equations that arise in climate physics. The perturbative procedure produces moments in terms of integral delay equations, whose order by order decay is characterized in a Floquet-like sense. Both additive and multiplicative sources of noise are discussed and the question of how the nature of the noise influences the results is addressed theoretically and numerically. By invoking the Martingale property, we rationalize the transformation of the underlying Stratonovich form of the model to an Ito form, independent of whether the noise is additive or multiplicative. The generality of the analysis is demonstrated by developing it both for a Brownian particle moving in a periodically forced quartic potential, which acts as a simple model of stochastic resonance, as well as for our more complex climate physics model. The validity of the approach is shown by comparison with numerical solutions. The particular climate dynamics problem upon which we focus involves a low-order model for the evolution of Arctic sea ice under the influence of increasing greenhouse gas forcing ΔF{sub 0}. The deterministic model, developed by Eisenman and Wettlaufer [“Nonlinear threshold behavior during the loss of Arctic sea ice,” Proc. Natl. Acad. Sci. U.S.A. 106(1), 28–32 (2009)] exhibits several transitions as ΔF{sub 0} increases and the stochastic analysis is used to understand the manner in which noise influences these transitions and the stability of the system.

  13. Transport through correlated systems with density functional theory

    Science.gov (United States)

    Kurth, S.; Stefanucci, G.

    2017-10-01

    We present recent advances in density functional theory (DFT) for applications in the field of quantum transport, with particular emphasis on transport through strongly correlated systems. We review the foundations of the popular Landauer–Büttiker(LB)  +  DFT approach. This formalism, when using approximations to the exchange-correlation (xc) potential with steps at integer occupation, correctly captures the Kondo plateau in the zero bias conductance at zero temperature but completely fails to capture the transition to the Coulomb blockade (CB) regime as the temperature increases. To overcome the limitations of LB  +  DFT, the quantum transport problem is treated from a time-dependent (TD) perspective using TDDFT, an exact framework to deal with nonequilibrium situations. The steady-state limit of TDDFT shows that in addition to an xc potential in the junction, there also exists an xc correction to the applied bias. Open shell molecules in the CB regime provide the most striking examples of the importance of the xc bias correction. Using the Anderson model as guidance we estimate these corrections in the limit of zero bias. For the general case we put forward a steady-state DFT which is based on one-to-one correspondence between the pair of basic variables, steady density on and steady current across the junction and the pair local potential on and bias across the junction. Like TDDFT, this framework also leads to both an xc potential in the junction and an xc correction to the bias. Unlike TDDFT, these potentials are independent of history. We highlight the universal features of both xc potential and xc bias corrections for junctions in the CB regime and provide an accurate parametrization for the Anderson model at arbitrary temperatures and interaction strengths, thus providing a unified DFT description for both Kondo and CB regimes and the transition between them.

  14. Dynamical systems with constraints: applications to the non-holonomical systems and the string theory

    International Nuclear Information System (INIS)

    Negri, L.J.

    1982-01-01

    A tecnique permiting the construction of a lagrangian function for nao-holononic systems is established. The classical formalism of the relativistic strings is discussed in the point of view of the Dirac theory for singular systems and in the context of a problem of two-dimensional surface immersion in space-time. It is shown how to solve the problem corresponding to the immersion in the case of free-finite and open strings by the specification of a non-conventional gauge. The relation between the string theory and Maxwell fields of place 2 is analyzed and the properties of string 'current density' to obtain new information about the model is explored. (L.C.) [pt

  15. Hildegard Peplau meets family systems nursing: innovation in theory-based practice.

    Science.gov (United States)

    Forchuk, C; Dorsay, J P

    1995-01-01

    Nursing theories which have evolved from mental health--psychiatric nursing have focused on the individual nurse-client relationship. Other nursing theories generally focus on the individual as client. Therefore, nurses working with families may have difficulty in applying these frameworks to their practice. Nursing theories need to be expanded to include families, groups and communities more explicitly. The well established theory of Hildegard Peplau, which previous studies have found to be the theory most frequently used by psychiatric nurses, and the family systems nursing theory of Wright and Leahey share a complementary focus. Both theories form part of the interpersonal paradigm of nursing; both view nursing from an interactional perspective, rather than focusing on individuals. Use of a combined theoretical approach offers several advantages. The approach explicitly considers both the individual and the family. The combination provides grounding for family work in an articulated nursing theory.

  16. Integrating Social Capital Theory, Social Cognitive Theory, and the Technology Acceptance Model to Explore a Behavioral Model of Telehealth Systems

    Directory of Open Access Journals (Sweden)

    Chung-Hung Tsai

    2014-05-01

    Full Text Available Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory, technological factors (TAM, and system self-efficacy (social cognitive theory in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively, which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities.

  17. Integrating Social Capital Theory, Social Cognitive Theory, and the Technology Acceptance Model to Explore a Behavioral Model of Telehealth Systems

    Science.gov (United States)

    Tsai, Chung-Hung

    2014-01-01

    Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM) to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory), technological factors (TAM), and system self-efficacy (social cognitive theory) in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM) was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation) significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively), which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities. PMID:24810577

  18. Integrating social capital theory, social cognitive theory, and the technology acceptance model to explore a behavioral model of telehealth systems.

    Science.gov (United States)

    Tsai, Chung-Hung

    2014-05-07

    Telehealth has become an increasingly applied solution to delivering health care to rural and underserved areas by remote health care professionals. This study integrated social capital theory, social cognitive theory, and the technology acceptance model (TAM) to develop a comprehensive behavioral model for analyzing the relationships among social capital factors (social capital theory), technological factors (TAM), and system self-efficacy (social cognitive theory) in telehealth. The proposed framework was validated with 365 respondents from Nantou County, located in Central Taiwan. Structural equation modeling (SEM) was used to assess the causal relationships that were hypothesized in the proposed model. The finding indicates that elderly residents generally reported positive perceptions toward the telehealth system. Generally, the findings show that social capital factors (social trust, institutional trust, and social participation) significantly positively affect the technological factors (perceived ease of use and perceived usefulness respectively), which influenced usage intention. This study also confirmed that system self-efficacy was the salient antecedent of perceived ease of use. In addition, regarding the samples, the proposed model fitted considerably well. The proposed integrative psychosocial-technological model may serve as a theoretical basis for future research and can also offer empirical foresight to practitioners and researchers in the health departments of governments, hospitals, and rural communities.

  19. Revisiting Bourdieu: Alternative Educational Systems in the Light of the Theory of Social and Cultural Reproduction

    Science.gov (United States)

    Azaola, Marta Cristina

    2012-01-01

    The paper reflects upon the principles and practice of an alternative educational system operating in rural Mexico in the light of Bourdieu's theory of cultural and social reproduction. Bourdieu's theory seeks to explain processes of reproduction of power relations within schools and society; whereas alternative educational systems seek to expand…

  20. Set Theory Applied to Uniquely Define the Inputs to Territorial Systems in Emergy Analyses

    Science.gov (United States)

    The language of set theory can be utilized to represent the emergy involved in all processes. In this paper we use set theory in an emergy evaluation to ensure an accurate representation of the inputs to territorial systems. We consider a generic territorial system and we describ...

  1. A novel embryological theory of autism causation involving endogenous biochemicals capable of initiating cellular gene transcription: a possible link between twelve autism risk factors and the autism 'epidemic'.

    Science.gov (United States)

    King, Chiara R

    2011-05-01

    post-1980 increase in US autism diagnoses. In addition to explaining the epidemic within the wider retinoic acid/estradiol model of causation, this theory leads to potential explanations for certain genetic findings in autism, autistic regression, and changing trends in autism symptomatology with regard to mental retardation, wheat allergy, and gastrointestinal problems. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. The Conceptual Mechanism for Viable Organizational Learning Based on Complex System Theory and the Viable System Model

    Science.gov (United States)

    Sung, Dia; You, Yeongmahn; Song, Ji Hoon

    2008-01-01

    The purpose of this research is to explore the possibility of viable learning organizations based on identifying viable organizational learning mechanisms. Two theoretical foundations, complex system theory and viable system theory, have been integrated to provide the rationale for building the sustainable organizational learning mechanism. The…

  3. Solvable Relativistic Hydrogenlike System in Supersymmetric Yang-Mills Theory

    DEFF Research Database (Denmark)

    Caron-Huot, Simon; Henn, Johannes M.

    2014-01-01

    this symmetry? In this Letter we show that the answer is positive: in the nonrelativistic limit, we identify the dual conformal symmetry of planar N=4 super Yang-Mills theory with the well-known symmetries of the hydrogen atom. We point out that the dual conformal symmetry offers a novel way to compute......he classical Kepler problem, as well as its quantum mechanical version, the hydrogen atom, enjoys a well-known hidden symmetry, the conservation of the Laplace-Runge-Lenz vector, which makes these problems superintegrable. Is there a relativistic quantum field theory extension that preserves...... the spectrum of bound states of massive W bosons in the theory. We perform nontrivial tests of this setup at weak and strong coupling and comment on the possible extension to arbitrary values of the coupling....

  4. Solvable relativistic hydrogenlike system in supersymmetric Yang-Mills theory.

    Science.gov (United States)

    Caron-Huot, Simon; Henn, Johannes M

    2014-10-17

    The classical Kepler problem, as well as its quantum mechanical version, the hydrogen atom, enjoys a well-known hidden symmetry, the conservation of the Laplace-Runge-Lenz vector, which makes these problems superintegrable. Is there a relativistic quantum field theory extension that preserves this symmetry? In this Letter we show that the answer is positive: in the nonrelativistic limit, we identify the dual conformal symmetry of planar N = 4 super Yang-Mills theory with the well-known symmetries of the hydrogen atom. We point out that the dual conformal symmetry offers a novel way to compute the spectrum of bound states of massive W bosons in the theory. We perform nontrivial tests of this setup at weak and strong coupling and comment on the possible extension to arbitrary values of the coupling.

  5. Affect Theory and Autoethnography in Ordinary Information Systems

    DEFF Research Database (Denmark)

    Bødker, Mads; Chamberlain, Alan

    2016-01-01

    This paper uses philosophical theories of affect as a lens for exploring autoethnographic renderings of everyday experience with information technology. Affect theories, in the paper, denote a broad trend in post-humanistic philosophy that explores sensation and feeling as emergent and relational...... precognitive forces that impinge on a body and its capacity to act. A necessarily truncated account of affect theory, and three autoethnographic vignettes are presented to complement the philosophical exposition and to provide reflections on possible empirical tactics for affective research in IS. Inspired...... by the challenges to IS reflected in Yoo’s notion of Experiential Computing, the paper contributes with examples of how everyday attentiveness to the senses can unveil new forms of embodiment related to ‘living with technology’. It suggests that feelings (both sensory visceral as well as more generalized moods...

  6. Quantization of dynamical systems and stochastic control theory

    International Nuclear Information System (INIS)

    Guerra, F.; Morato, L.M.

    1982-09-01

    In the general framework of stochastic control theory we introduce a suitable form of stochastic action associated to the controlled process. Then a variational principle gives all main features of Nelson's stochastic mechanics. In particular we derive the expression of the current velocity field as the gradient of the phase action. Moreover the stochastic corrections to the Hamilton-Jacobi equation are in agreement with the quantum mechanical form of the Madelung fluid (equivalent to the Schroedinger equation). Therefore stochastic control theory can provide a very simple model simulating quantum mechanical behavior

  7. The Theory and Implementation of Electronic Voting Systems

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Groth, Jens; Salomonsen, Gorm

    2002-01-01

    We describe the theory behind a practical voting scheme based on homomorphic encryption. We give an example of an ElGamal-style encryption scheme, which can be used as the underlying cryptosystem. Then, we present efficient honest verifier zero-knowledge proofs that make the messages in the voting...

  8. BMN gauge theory as a quantum mechanical system

    DEFF Research Database (Denmark)

    Beisert, N.; Kristjansen, C.; Plefka, J.

    2003-01-01

    We rigorously derive an effective quantum mechanical Hamiltonian from N = 4 gauge theory in the BMN limit. Its eigenvalues yield the exact one-loop anomalous dimensions of scalar two-impurity BMN operators for all genera. It is demonstrated that this reformulation vastly simplifies computations. ...

  9. Random matrix theory for pseudo-Hermitian systems: Cyclic blocks

    Indian Academy of Sciences (India)

    Abstract. We discuss the relevance of random matrix theory for pseudo-Hermitian sys- tems, and, for Hamiltonians that break parity P and time-reversal invariance T. In an attempt to understand the random Ising model, we present the treatment of cyclic asym- metric matrices with blocks and show that the nearest-neighbour ...

  10. Comment on the three-body theory for period changes in RS CVn systems

    Science.gov (United States)

    Van Buren, D.

    1986-01-01

    In the three-body theory for period variations in RS CVn systems, the timing residuals are interpreted as light-travel time differences as the eclipsing system moves about the barycenter of the triple. These residuals can require a larger orbit than Kepler's law allows, given the time scale of the period variations. For only two of eight systems investigated, SV Cam and V471 Tau, is the theory plausible in that the inferred barycentric motion of the binary is smaller than the orbit of the third body, and the inferred properties of the third body are both reasonable and consistent with its remaining hidden. The theory is thus not a general theory for period changes. Observational testing of the theory is straightforward and may lead to the detection of 'brown dwarfs' associated with eclipsing systems through their kinematic effects.

  11. Information theory in systems biology. Part I: Gene regulatory and metabolic networks.

    Science.gov (United States)

    Mousavian, Zaynab; Kavousi, Kaveh; Masoudi-Nejad, Ali

    2016-03-01

    "A Mathematical Theory of Communication", was published in 1948 by Claude Shannon to establish a framework that is now known as information theory. In recent decades, information theory has gained much attention in the area of systems biology. The aim of this paper is to provide a systematic review of those contributions that have applied information theory in inferring or understanding of biological systems. Based on the type of system components and the interactions between them, we classify the biological systems into 4 main classes: gene regulatory, metabolic, protein-protein interaction and signaling networks. In the first part of this review, we attempt to introduce most of the existing studies on two types of biological networks, including gene regulatory and metabolic networks, which are founded on the concepts of information theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Robust simplifications of multiscale biochemical networks

    Directory of Open Access Journals (Sweden)

    Zinovyev Andrei

    2008-10-01

    Full Text Available Abstract Background Cellular processes such as metabolism, decision making in development and differentiation, signalling, etc., can be modeled as large networks of biochemical reactions. In order to understand the functioning of these systems, there is a strong need for general model reduction techniques allowing to simplify models without loosing their main properties. In systems biology we also need to compare models or to couple them as parts of larger models. In these situations reduction to a common level of complexity is needed. Results We propose a systematic treatment of model reduction of multiscale biochemical networks. First, we consider linear kinetic models, which appear as "pseudo-monomolecular" subsystems of multiscale nonlinear reaction networks. For such linear models, we propose a reduction algorithm which is based on a generalized theory of the limiting step that we have developed in 1. Second, for non-linear systems we develop an algorithm based on dominant solutions of quasi-stationarity equations. For oscillating systems, quasi-stationarity and averaging are combined to eliminate time scales much faster and much slower than the period of the oscillations. In all cases, we obtain robust simplifications and also identify the critical parameters of the model. The methods are demonstrated for simple examples and for a more complex model of NF-κB pathway. Conclusion Our approach allows critical parameter identification and produces hierarchies of models. Hierarchical modeling is important in "middle-out" approaches when there is need to zoom in and out several levels of complexity. Critical parameter identification is an important issue in systems biology with potential applications to biological control and therapeutics. Our approach also deals naturally with the presence of multiple time scales, which is a general property of systems biology models.

  13. Backup computer theory for process control computer systems

    International Nuclear Information System (INIS)

    Davidson, K.E.

    1977-01-01

    Process control computer systems should have some type of back-up system which could automatically assume control of a process if the main computer system should fail. This subject is discussed in general and as relates to a specific process. This process is the computer control system for the Almarez Nuclear Power Plant installation at Almarez in Spain. The system configuration includes two main computer control systems, with one backup system which can replace either of the main systems. Criteria for determining an adequate backup system will be discussed including cost, reliability, and criticality of the computer system and process

  14. Reconceptualizing children's complex discharge with health systems theory: novel integrative review with embedded expert consultation and theory development.

    Science.gov (United States)

    Noyes, Jane; Brenner, Maria; Fox, Patricia; Guerin, Ashleigh

    2014-05-01

    To report a novel review to develop a health systems model of successful transition of children with complex healthcare needs from hospital to home. Children with complex healthcare needs commonly experience an expensive, ineffectual and prolonged nurse-led discharge process. Children gain no benefit from prolonged hospitalization and are exposed to significant harm. Research to enable intervention development and process evaluation across the entire health system is lacking. Novel mixed-method integrative review informed by health systems theory. DATA  CINAHL, PsychInfo, EMBASE, PubMed, citation searching, personal contact. REVIEW  Informed by consultation with experts. English language studies, opinion/discussion papers reporting research, best practice and experiences of children, parents and healthcare professionals and purposively selected policies/guidelines from 2002-December 2012 were abstracted using Framework synthesis, followed by iterative theory development. Seven critical factors derived from thirty-four sources across five health system levels explained successful discharge (new programme theory). All seven factors are required in an integrated care pathway, with a dynamic communication loop to facilitate effective discharge (new programme logic). Current health system responses were frequently static and critical success factors were commonly absent, thereby explaining ineffectual discharge. The novel evidence-based model, which reconceptualizes 'discharge' as a highly complex longitudinal health system intervention, makes a significant contribution to global knowledge to drive practice development. Research is required to develop process and outcome measures at different time points in the discharge process and future trials are needed to determine the effectiveness of integrated health system discharge models. © 2013 John Wiley & Sons Ltd.

  15. Effect of contrasting crop rotation systems on soil chemical and biochemical properties and plant root growth in organic farming: First results

    Directory of Open Access Journals (Sweden)

    Elga Monaci

    2017-12-01

    Full Text Available Organic farming is claimed to improve soil fertility. Nonetheless, among organic practices, net C-inputs may largely vary in amount and composition and produce different soil conditions for microbial activity and plant-root system adaptation and development. In this study, we hypothesised that, in the regime of organic agriculture, soil chemical and biochemical properties can substantially differ under contrasting crop rotation systems and produce conditions of soil fertility to which the plant responds through diverse growth and production. The impact of 13 years of alfalfa-crop rotation (P-C and annual crop rotation (A-C was evaluated on the build up of soil organic carbon (SOC, active (light fraction organic matter, LFOM; water soluble organic carbon, WSOC and humic fraction [fulvic acids carbon (FAC, humic acids carbon (HAC], soil biochemical properties [microbial biomass carbon (MBC, basal respiration (dBR, alkaline phosphatase (AmP, arylsulfatase (ArS, orto-diphenoloxidase (o- DPO] and the amount of available macro-nutrients (N, P, and S at two different soil depths (0-10 cm and 10-30 cm before and after cultivation of wheat. We also studied the response of root morphology, physiology and yield of the plant-root system of wheat. Results showed that the level of soil fertility and plant-root system behaviour substantially differed under the two crop rotation systems investigated here. We observed high efficiency of the P-C soil in the build up of soil organic carbon, as it was 2.9 times higher than that measured in the A-C soil. With the exception of o-DPO, P-C soil always showed a higher level of AmP and ArS activity and an initial lower amount of available P and S. The P-C soil showed higher rootability and promoted thinner roots and higher root density. In the P-C soil conditions, the photosynthesis and yield of durum wheat were also favoured. Finally, cultivation of wheat caused an overall depletion of the accrued fertility of soil

  16. An Abstraction Theory for Qualitative Models of Biological Systems

    Directory of Open Access Journals (Sweden)

    Richard Banks

    2010-10-01

    Full Text Available Multi-valued network models are an important qualitative modelling approach used widely by the biological community. In this paper we consider developing an abstraction theory for multi-valued network models that allows the state space of a model to be reduced while preserving key properties of the model. This is important as it aids the analysis and comparison of multi-valued networks and in particular, helps address the well-known problem of state space explosion associated with such analysis. We also consider developing techniques for efficiently identifying abstractions and so provide a basis for the automation of this task. We illustrate the theory and techniques developed by investigating the identification of abstractions for two published MVN models of the lysis-lysogeny switch in the bacteriophage lambda.

  17. Incorporating Behavioral Trust Theory Into System Development for Ubiquitous Applications

    OpenAIRE

    Hoffmann, Holger; Söllner, Matthias

    2014-01-01

    Trust has been shown to be a key factor for technology adoption by users, that is, users prefer to use applications they trust. While existing literature on trust originating in computer science mostly revolves around aspects of information security, authentication, etc., research on trust in automation-originating from behavioral sciences-almost exclusively focuses on the sociotechnical context in which applications are embedded. The behavioral theory of trust in automation aims at explainin...

  18. Quantum dissipative systems from theory of continuous measurements

    International Nuclear Information System (INIS)

    Mensky, Michael B.; Stenholm, Stig

    2003-01-01

    We apply the restricted-path-integral (RPI) theory of non-minimally disturbing continuous measurements for correct description of frictional Brownian motion. The resulting master equation is automatically of the Lindblad form, so that the difficulties typical of other approaches do not exist. In the special case of harmonic oscillator the known familiar master equation describing its frictionally driven Brownian motion is obtained. A thermal reservoir as a measuring environment is considered

  19. Scaling theory of quantum resistance distributions in disordered systems

    International Nuclear Information System (INIS)

    Jayannavar, A.M.

    1991-01-01

    The large scale distribution of quantum Ohmic resistance of a disorderd one-dimensional conductor is derived explicitly. It is shown that in the thermodynamic limit this distribution is characterized by two independent parameters for strong disorder, leading to a two-parameter scaling theory of localization. Only in the limit of weak disorder single parameter scaling consistent with existing theoretical treatments is recovered. (author). 33 refs., 4 figs

  20. Biochemical composition of seston in two upwelling sites within the Humboldt Current System (21°S to 23°S): Summer conditions

    Science.gov (United States)

    Isla, Enrique; Homs, Patricia; Sañé, Elisabet; Escribano, Rubén; Claramunt, Gabriel; Teixidó, Nuria

    2010-07-01

    The biochemical composition of seston within the Humboldt Current System (HCS) in two bays off northern Chile (21°S-23°S) was assessed to estimate its chemical quality as potential food supply for benthic communities, large zooplankton and fish larvae. As part of the CENSOR project, in the summer of 2006 physical and biochemical variables were analyzed in Chipana and Mejillones Bays during one week at four depths determined by the occurrence of the upper boundary of the oxygen minimum zone and fluorescence peaks. The depth of the oxy- and pycnoclines controlled the distribution of biochemical variables in both bays. There were significant differences in the concentration of protein (PRT), lipid (LPD) and carbohydrates (CHO) among depths in both bays. The differences were also found in the PRT and LPD contribution to the biopolymeric carbon (BPC) among bays and among depths in the case of CHO. However, the concentration of suspended particulate matter and biogenic silica (bSi) were similar in both bays. PRT, LPD and CHO showed the highest concentrations in the upper meters of the water column and small peaks close to the seabed related to sediment resuspension and/or lateral transport. In Chipana Bay, the high nutritive quality of seston occurring near the seabed suggests a rapid sinking of diatom aggregates and a reduced respiration of the particulate organic matter. PRT, LPD and CHO varied between 0.05 and 0.47 mg l - 1 , 0.06 and 0.39 mg l - 1 and 0.07 and 0.51 mg l - 1 , respectively. LPD were the most important contributors to the BPC in both bays. The seston in these bays presented a high PRT and LPD content in comparison to a number of settings of different latitudes and oceanographic characteristics. The high quantity and biochemical quality of the particulate matter in both bays may reflect the high productivity of this zone and partially explain their condition as spawning areas within the HCS.

  1. Planets and planetarians. A history of theories of the origin of planetary systems

    International Nuclear Information System (INIS)

    Jaki, S.L.

    1978-01-01

    A critical review is presented of theories of the origin of planetary systems. The book deals chronologically with the subject from Greek times to the present. The last of the eight chapters covers the post-war period. Particular attention is paid to theories of the origin of our own planetary system and to the degree of frequency of planetary systems (in particular, the frequency of planets carrying life in some form) in the universe. (U.K.)

  2. Irregular blocks, N = 2 gauge theory and Mathieu system

    Science.gov (United States)

    Piatek, M. R.; Pietrykowski, A. R.

    2016-01-01

    The Alday-Gayotto-Tachikawa (AGT) conjecture relates 4d N = 2, SU(2) SYM theories with Nf matter hypermultiplets to 2d CFT. In case of pure 4d N = 2, SU(2) SYM there is a corresponding irregular conformal block in 2d CFT. The AGT correspondence may be extended within a certain limit (the Nekrasov-Shataschvili limit) to the correspondence between an effective twisted superpotentials of 2d N = 2 SUSY and the Zamolodchikov's “classical” conformal blocks. When narrowed to the pure 4d N = 2 SYM case its limit is related to an irregular classical conformal block. It will be shown that according to the triple correspondence (2dCFT/Gauge/Bethe - c.f. Piatek's talk) the irregular classical conformal block yields spectrum of Mathieu operator. The latter can be obtained as a “classical” limit of the null vector decoupling equation for three-point degenerate irregular block. It will also be shown that the Mathieu spectrum can be also obtained from the limit of the pure gauge theory as a solution of the saddle point equation as well as from the Bohr-Sommerfeld quantization of the Seiberg-Witten theory.

  3. Analyzing Real-Time Systems: Theory and Tools

    DEFF Research Database (Denmark)

    Hune, Thomas Seidelin

    The main topic of this dissertation is the development and use of methods for formal reasoning about the correctness of real-time systems, in particular methods and tools to handle new classes of problems. In real-time systems the correctness of the system does not only depend on the order in which...... actions take place, but also the timing of the actions. The formal reasoning presented here is based on (extensions of) the model of timed automata and tools supporting this model, mainly UPPAAL. Real-time systems are often part of safety critical systems e.g. control systems for planes, trains......, or factories, though also everyday electronics as audio/video equipment and (mobile) phones are considered real-time systems. Often these systems are concurrent systems with a number of components interacting, and reasoning about such systems is notoriously difficult. However, since most of the systems...

  4. Coenzyme Q10 treatments influence the lifespan and key biochemical resistance systems in the honeybee, Apis mellifera.

    Science.gov (United States)

    Strachecka, Aneta; Olszewski, Krzysztof; Paleolog, Jerzy; Borsuk, Grzegorz; Bajda, Milena; Krauze, Magdalena; Merska, Malwina; Chobotow, Jacek

    2014-07-01

    Natural bioactive preparations that will boost apian resistance, aid body detoxification, or fight crucial bee diseases are in demand. Therefore, we examined the influence of coenzyme Q10 (CoQ10, 2,3-dimethoxy, 5-methyl, 6-decaprenyl benzoquinone) treatment on honeybee lifespan, Nosema resistance, the activity/concentration of antioxidants, proteases and protease inhibitors, and biomarkers. CoQ10 slows age-related metabolic processes. Workers that consumed CoQ10 lived longer than untreated controls and were less infested with Nosema spp. Relative to controls, the CoQ10-treated workers had higher protein concentrations that increased with age but then they decreased in older bees. CoQ10 treatments increased the activities of antioxidant enzymes (superoxide dismutase, GPx, catalase, glutathione S-transferase), protease inhibitors, biomarkers (aspartate aminotransferase, alkaline phosphatase, alanine aminotransferase), the total antioxidant potential level, and concentrations of uric acid and creatinine. The activities of acidic, neutral, and alkaline proteases, and concentrations of albumin and urea were lower in the bees that were administered CoQ10. CoQ10 could be taken into consideration as a natural diet supplement in early spring before pollen sources become available in the temperate Central European climate. A response to CoQ10 administration that is similar to mammals supports our view that Apis mellifera is a model organism for biochemical gerontology. © 2014 Wiley Periodicals, Inc.

  5. Generalized Floquet theory: application to dynamical systems with memory and Bloch's theorem for nonlocal potentials.

    Science.gov (United States)

    Traversa, Fabio L; Di Ventra, Massimiliano; Bonani, Fabrizio

    2013-04-26

    Floquet theory is a powerful tool in the analysis of many physical phenomena, and extended to spatial coordinates provides the basis for Bloch's theorem. However, in its original formulation it is limited to linear systems with periodic coefficients. Here, we extend the theory by proving a theorem for the general class of systems including linear operators commuting with the period-shift operator. The present theorem greatly expands the range of applicability of Floquet theory to a multitude of phenomena that were previously inaccessible with this type of analysis, such as dynamical systems with memory. As an important extension, we also prove Bloch's theorem for nonlocal potentials.

  6. Prediction on corrosion rate of pipe in nuclear power system based on optimized grey theory

    International Nuclear Information System (INIS)

    Chen Yonghong; Zhang Dafa; Chen Dengke; Jiang Wei

    2007-01-01

    For the prediction of corrosion rate of pipe in nuclear power system, the pre- diction error from the grey theory is greater, so a new method, optimized grey theory was presented in the paper. A comparison among predicted results from present and other methods was carried out, and it is seem that optimized grey theory is correct and effective for the prediction of corrosion rate of pipe in nuclear power system, and it provides a fundamental basis for the maintenance of pipe in nuclear power system. (authors)

  7. The Marriage of Science and Spirit: Dynamic Systems Theory and the Development of Spirituality

    Science.gov (United States)

    Cupit, C. Glenn

    2007-01-01

    The adherence of traditional developmental theories to a linear paradigm is incompatible with the nature of "spirit". Dynamic Systems Theory (DST), a recent contributor to understanding child development, offers an alternative which avoids these paradigmatic limitations. Concepts of agency, "top-down" causality, emergence and…

  8. Cybernetically sound organizational structures II: Relating de Sitter's design theory to Beer's viable system model

    NARCIS (Netherlands)

    Achterbergh, J.M.I.M.; Vriens, D.J.

    2011-01-01

    - Purpose – The purpose of this paper is to show how the viable system model (VSM) and de Sitter's design theory can complement each other in the context of the diagnosis and design of viable organizations. - Design/methodology/approach – Key concepts from Beer's model and de Sitter's design theory

  9. Internally directed cognition and mindfulness: An integrative perspective derived from predictive and reactive control systems theory

    NARCIS (Netherlands)

    M. Tops (Mattie); M.A.S. Boksem (Maarten); M. Quirin (Markus); H. IJzerman (Hans); S.L. Koole (Sander)

    2014-01-01

    textabstractIn the present paper, we will apply the predictive and reactive control systems (PARCS) theory as a framework that integrates competing theories of neural substrates of awareness by describing the "default mode network" (DMN) and anterior insula (AI) as parts of two different behavioral

  10. Autonomy and the Ambiguity of Biological Rationalities: Systems Theory, ADHD and Kant

    Science.gov (United States)

    Haye, Andrés; Matus, Claudia; Cottet, Pablo; Niño, Sebastián

    2018-01-01

    We present a theoretical review of notions of autonomy to show how they organize discourses within social sciences around the biological reality of ideal self-regulating individuals. First, we reconstruct key meanings of autonomy in biological theory, focusing on theories of autopoietic systems and their connections to constructivist…

  11. Deterministic Local Sensitivity Analysis of Augmented Systems - I: Theory

    International Nuclear Information System (INIS)

    Cacuci, Dan G.; Ionescu-Bujor, Mihaela

    2005-01-01

    This work provides the theoretical foundation for the modular implementation of the Adjoint Sensitivity Analysis Procedure (ASAP) for large-scale simulation systems. The implementation of the ASAP commences with a selected code module and then proceeds by augmenting the size of the adjoint sensitivity system, module by module, until the entire system is completed. Notably, the adjoint sensitivity system for the augmented system can often be solved by using the same numerical methods used for solving the original, nonaugmented adjoint system, particularly when the matrix representation of the adjoint operator for the augmented system can be inverted by partitioning

  12. An Annotated Bibliography of Literature Integrating Organizational and Systems Theory

    Science.gov (United States)

    1985-09-01

    effort. Four themes characterize this volume: (1) Laboratory Approach as a Genus - a way of learning which is at once convenient and potent. -154- The...Nydegger, R. V. & Owen, G. The norm of equity in a three-person majority game. BehavioraZ7 Science, 1977, 22, 32-37. The study of n-person game theory...psychological considerations to arrive at solutions. Since the norm of equity is widely held, it was predicted that the A.B coalition would result most

  13. Ab initio theory of perpendicular transport in layered magnetic systems

    Czech Academy of Sciences Publication Activity Database

    Kudrnovský, Josef; Drchal, Václav; Turek, Ilja; Dederichs, P. H.; Weinberger, P.; Bruno, P.

    2002-01-01

    Roč. 240, - (2002), s. 177-179 ISSN 0304-8853 R&D Projects: GA AV ČR IAA1010829; GA ČR GA202/00/0122; GA MŠk OC P5.30; GA MŠk OC P3.40; GA MŠk OC P3.70 Institutional research plan: CEZ:AV0Z1010914 Keywords : magnetoresistance -theory * ferromagnetic multilayers * disorder-alloys * electronic structure Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.046, year: 2002

  14. Application of linear systems theory to characterize coherence scanning interferometry

    Science.gov (United States)

    Mandal, Rahul; Palodhi, Kanik; Coupland, Jeremy; Leach, Richard; Mansfield, Daniel

    2012-04-01

    This paper considers coherence scanning interferometry as a linear filtering operation that is characterised by a point spread function in the space domain or equivalently a transfer function in the frequency domain. The applicability of the theory is discussed and the effects of these functions on the measured interferograms, and their influence on the resulting surface measurements, are described. The practical characterisation of coherence scanning interferometers using a spherical reference artefact is then considered and a new method to compensate measurement errors, based on a modified inverse filter, is demonstrated.

  15. The Foundation Role for Theories of Agency in Understanding Information Systems Design

    Directory of Open Access Journals (Sweden)

    Robert Johnston

    2002-11-01

    Full Text Available In this paper we argue that theories of agency form a foundation upon which we can build a deeper understanding of information systems design. We do so by firstly recognising that information systems are part of purposeful sociotechnical systems and that consequently theories of agency may help in understanding them. We then present two alternative theories of agency (deliberative and situational, mainly drawn from the robotics and artificial intelligence disciplines, and in doing so, we note that existing information system design methods and ontological studies of those methods implicitly adhere to the deliberative theory of agency. We also note that while there are advantages in specific circumstances from utilising the situated theory of agency in designing complex systems, because of their differing ontological commitments, such systems would be difficult to analyse and evaluate using ontologies currently used in information systems. We then provide evidence that such situational information systems can indeed exist, by giving a specific example (the Kanban system, which has emerged from manufacturing practice. We conclude that information systems are likely to benefit from creating design approaches supporting the production of situational systems.

  16. Regularity theory for quasilinear elliptic systems and Monge—Ampère equations in two dimensions

    CERN Document Server

    Schulz, Friedmar

    1990-01-01

    These lecture notes have been written as an introduction to the characteristic theory for two-dimensional Monge-Ampère equations, a theory largely developed by H. Lewy and E. Heinz which has never been presented in book form. An exposition of the Heinz-Lewy theory requires auxiliary material which can be found in various monographs, but which is presented here, in part because the focus is different, and also because these notes have an introductory character. Self-contained introductions to the regularity theory of elliptic systems, the theory of pseudoanalytic functions and the theory of conformal mappings are included. These notes grew out of a seminar given at the University of Kentucky in the fall of 1988 and are intended for graduate students and researchers interested in this area.

  17. Smart modeling and simulation for complex systems practice and theory

    CERN Document Server

    Ren, Fenghui; Zhang, Minjie; Ito, Takayuki; Tang, Xijin

    2015-01-01

    This book aims to provide a description of these new Artificial Intelligence technologies and approaches to the modeling and simulation of complex systems, as well as an overview of the latest scientific efforts in this field such as the platforms and/or the software tools for smart modeling and simulating complex systems. These tasks are difficult to accomplish using traditional computational approaches due to the complex relationships of components and distributed features of resources, as well as the dynamic work environments. In order to effectively model the complex systems, intelligent technologies such as multi-agent systems and smart grids are employed to model and simulate the complex systems in the areas of ecosystem, social and economic organization, web-based grid service, transportation systems, power systems and evacuation systems.

  18. Renormalization group theory for Kondo breakdown in Kondo lattice systems

    International Nuclear Information System (INIS)

    Ballmann, K; Nejati, A; Kroha, J

    2015-01-01

    We present a renormalization group (RG) theory for the breakdown of Kondo screening in the Kondo lattice model (KLM) without pre-assumptions about the competition between Kondo effect and magnetic ordering or Fermi surface criticality. We show that the vertex between a single, local Kondo spin and the extended conduction electrons obtains RKKY- induced, non-local contributions in the in-and out-going coordinates of scattering electrons due to scattering at surrounding Kondo sites, but it remains local in the Kondo spin position. This enables the existence of a local Kondo screening scale T K (y) in the KLM, controlled by the effective RKKY coupling parameter y. T K (y) is determined by the RG flow of the local spin exchange coupling in the presence of the self-consistent spin response on surrounding Kondo sites. We show that T K (y) exhibits universal behavior and is suppressed by the antiferromagnetic RKKY coupling. Beyond a maximal RKKY parameter value y max Kondo screening ceases to exist even without magnetic ordering. The theory opens up the possibility of describing quantum critical scenarios involving spin wave instabilities or local Kondo breakdown on the same footing

  19. Robust power system stabilizer design with H∞ theory

    OpenAIRE

    Marjaneh Farhoodi; MohammadTaghi HamidiBeheshti; Ali Nejati

    2007-01-01

    In this paper, the H∞ robust control technique is presented to design a power system stabilizer. First, the H∞ standard problem is expressed and then, the modeling and stability analysis of power systems are studied. Finally, a H∞ power system stabilizer is designed and the simulation results are discussed.

  20. Developing open systems using theories and models of the world

    Energy Technology Data Exchange (ETDEWEB)

    Kokar, M.M.; Korona, Z. [Northeastern Univ., Boston, MA (United States)

    1996-12-31

    This paper considers an open system as such that can deal with inputs that were not anticipated by the designer. Using an ATR system as an example, we show how the combination of logic with software engineering techniques allowed us to improve the performance of the system.

  1. Introduction to Mathematical Systems Theory: A Behavioral Approach

    NARCIS (Netherlands)

    Polderman, Jan W.; Willems, J.C.

    1998-01-01

    This is a book about modelling, analysis, and control of linear time-invariant systems. The book uses what is called the behavioral approach towards mathematical modelling. Thus a system is viewed as a dynamical relation between manifest and latent variables. The emphasis is on dynamical systems

  2. A Formal Approach to User Interface Design using Hybrid System Theory Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Optimal Synthesis Inc.(OSI) proposes to develop an aiding tool for user interface design that is based on mathematical formalism of hybrid system theory. The...

  3. Time-dependent density functional theory for multi-component systems

    International Nuclear Information System (INIS)

    Tiecheng Li; Peiqing Tong

    1985-10-01

    The Runge-Gross version of Hohenberg-Kohn-Sham's density functional theory is generalized to multi-component systems, both for arbitrary time-dependent pure states and for arbitrary time-dependent ensembles. (author)

  4. Inventory management in the environment and the theory of constraints management accounting system throughput accounting

    OpenAIRE

    Elsukova Tatiana Vasilevna

    2014-01-01

    This article analyzes the techniques and methods of inventory management company with the information of a management accounting system based on the principles of the theory of constraints, both financial and non-financial.

  5. A Formal Approach to User Interface Design using Hybrid System Theory, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Optimal Synthesis Inc.(OSI) proposes to develop an aiding tool for user interface design that is based on mathematical formalism of hybrid system theory. The...

  6. Solar System constraints on a cosmologically viable f(R) theory

    International Nuclear Information System (INIS)

    Bisabr, Yousef

    2010-01-01

    Recently, a model f(R) theory is proposed (Miranda et al. (2009)) which is cosmologically viable and distinguishable from ΛCDM. We use chameleon mechanism to investigate viability of the model in terms of Solar System experiments.

  7. Inventory management in the environment and the theory of constraints management accounting system throughput accounting

    Directory of Open Access Journals (Sweden)

    Elsukova Tatiana Vasilevna

    2014-02-01

    Full Text Available This article analyzes the techniques and methods of inventory management company with the information of a management accounting system based on the principles of the theory of constraints, both financial and non-financial.

  8. A Theory of Transformative Agency in Linked Social-Ecological Systems

    Directory of Open Access Journals (Sweden)

    Frances R. Westley

    2013-09-01

    Full Text Available We reviewed the literature on leadership in linked social-ecological systems and combined it with the literature on institutional entrepreneurship in complex adaptive systems to develop a new theory of transformative agency in linked social-ecological systems. Although there is evidence of the importance of strategic agency in introducing innovation and transforming approaches to management and governance of such systems, there is no coherent theory to explain the wide diversity of strategies identified. Using Holling's adaptive cycle as a model of phases present in innovation and transformation of resilient social-ecological systems, overlaid by Dorado's model of opportunity context (opaque, hazy, transparent in complex adaptive systems, we propose a more coherent theory of strategic agency, which links particular strategies, on the part of transformative agents, to phases of system change.

  9. Applications of decision theory to computer-based adaptive instructional systems

    OpenAIRE

    Vos, Hendrik J.

    1988-01-01

    This paper considers applications of decision theory to the problem of instructional decision-making in computer-based adaptive instructional systems, using the Minnesota Adaptive Instructional System (MAIS) as an example. The first section indicates how the problem of selecting the appropriate amount of instruction in MAIS can be situated within the general framework of empirical Bayesian decision theory. The linear loss model and the classical test model are discussed in this context. The s...

  10. Living systems theory as a paradigm for organizational behavior: understanding humans, organizations, and social processes.

    Science.gov (United States)

    Vancouver, J B

    1996-07-01

    Living systems theories have been used to model human, organization, and communication processes. This paper attempts to describe these models and to highlight the isomorphisms among the models. Particular emphasis is given to self-regulating properties of humans as a subsystem of social systems. Attention is given to the advantages of generalizing across levels and phenomena and integrating the middle-range theories that dominate the field of organizational behavior. Three broad recommendations for future research are discussed.

  11. Learning control system design based on 2-D theory - An application to parallel link manipulator

    Science.gov (United States)

    Geng, Z.; Carroll, R. L.; Lee, J. D.; Haynes, L. H.

    1990-01-01

    An approach to iterative learning control system design based on two-dimensional system theory is presented. A two-dimensional model for the iterative learning control system which reveals the connections between learning control systems and two-dimensional system theory is established. A learning control algorithm is proposed, and the convergence of learning using this algorithm is guaranteed by two-dimensional stability. The learning algorithm is applied successfully to the trajectory tracking control problem for a parallel link robot manipulator. The excellent performance of this learning algorithm is demonstrated by the computer simulation results.

  12. Exploring a Theory Describing the Physics of Information Systems, a Physical Model of the Behavior of Information Systems

    National Research Council Canada - National Science Library

    Harmon, Scott

    2001-01-01

    .... The forces driving information flows arise from the existence of goal content. The workshop participants discussed various theories and considered experiments that characterize the macroscopic phenomena underlying complex information system behavior...

  13. Flame-Oxidized Stainless-Steel Anode as a Probe in Bioelectrochemical System-Based Biosensors to Monitor the Biochemical Oxygen Demand of Wastewater.

    Science.gov (United States)

    Liang, Qiaochu; Yamashita, Takahiro; Yamamoto-Ikemoto, Ryoko; Yokoyama, Hiroshi

    2018-02-16

    Biochemical oxygen demand (BOD) is a widely used index of water quality in wastewater treatment; however, conventional measurement methods are time-consuming. In this study, we analyzed a novel flame-oxidized stainless steel anode (FO-SSA) for use as the probe of bioelectrochemical system (BES)-based biosensors to monitor the BOD of treated swine wastewater. A thinner biofilm formed on the FO-SSA compared with that on a common carbon-cloth anode (CCA). The FO-SSA was superior to the CCA in terms of rapid sensing; the response time of the FO-SSA to obtain the value of R2 > 0.8 was 1 h, whereas the CCA required 4 h. These results indicate that the FO-SSA offers better performance than traditional CCAs in BES biosensors and can be used to improve biomonitoring of wastewater.

  14. Flame-Oxidized Stainless-Steel Anode as a Probe in Bioelectrochemical System-Based Biosensors to Monitor the Biochemical Oxygen Demand of Wastewater

    Directory of Open Access Journals (Sweden)

    Qiaochu Liang

    2018-02-01

    Full Text Available Biochemical oxygen demand (BOD is a widely used index of water quality in wastewater treatment; however, conventional measurement methods are time-consuming. In this study, we analyzed a novel flame-oxidized stainless steel anode (FO-SSA for use as the probe of bioelectrochemical system (BES-based biosensors to monitor the BOD of treated swine wastewater. A thinner biofilm formed on the FO-SSA compared with that on a common carbon-cloth anode (CCA. The FO-SSA was superior to the CCA in terms of rapid sensing; the response time of the FO-SSA to obtain the value of R2 > 0.8 was 1 h, whereas the CCA required 4 h. These results indicate that the FO-SSA offers better performance than traditional CCAs in BES biosensors and can be used to improve biomonitoring of wastewater.

  15. Development of 77Ge/77As parent-daughter system for periodic removal of 77As for environmental sanitation and biochemical purposes

    International Nuclear Information System (INIS)

    Olah, Zita; Doczi, Rita; Szuecs, Zoltan; Varga, Zoltan

    2015-01-01

    A simple method was developed for the separation of radioactive 77 As from neutron irradiated natural GeO 2 samples for environmental and biochemical studies. The method is based on the volatility of GeCl 4 . The GeCl 4 was co-evaporated from the reaction mixture with an azeotropic mixture of HCl and water, and immediately condensed into a separate finger part of the special glass apparatus which was cooled by liquid nitrogen. By inverting the room temperature and the deep frozen parts of the glass equipment after three half-lives of the 77 Ge the separation process can be repetitive, getting a special type of 77 Ge/ 77 As parent-daughter system. The radionuclidic purity of the remaining As fraction was found to be 99.95%. Its yield, however, drastically decreased in the second and subsequent separations.

  16. Theory of critical phenomena in finite-size systems scaling and quantum effects

    CERN Document Server

    Brankov, Jordan G; Tonchev, Nicholai S

    2000-01-01

    The aim of this book is to familiarise the reader with the rich collection of ideas, methods and results available in the theory of critical phenomena in systems with confined geometry. The existence of universal features of the finite-size effects arising due to highly correlated classical or quantum fluctuations is explained by the finite-size scaling theory. This theory (1) offers an interpretation of experimental results on finite-size effects in real systems; (2) gives the most reliable tool for extrapolation to the thermodynamic limit of data obtained by computer simulations; (3) reveals

  17. Modern theory of dynamical systems a tribute to Dmitry Victorovich Anosov

    CERN Document Server

    Katok, Anatole; Hertz, Federico Rodriguez

    2017-01-01

    This volume is a tribute to one of the founders of modern theory of dynamical systems, the late Dmitry Victorovich Anosov. It contains both original papers and surveys, written by some distinguished experts in dynamics, which are related to important themes of Anosov's work, as well as broadly interpreted further crucial developments in the theory of dynamical systems that followed Anosov's original work. Also included is an article by A. Katok that presents Anosov's scientific biography and a picture of the early development of hyperbolicity theory in its various incarnations, complete and partial, uniform and nonuniform.

  18. Employing Interpretive Research to Build Theory of Information Systems Practice

    Directory of Open Access Journals (Sweden)

    Bruce Rowlands

    2003-05-01

    Full Text Available This paper provides guidance and an example for carrying out research using an interpretive framework. Until quite recently, there has been little available in the IS literature to guide the interpretive researcher to build theory of IS practice. While structured as a typical research paper, this paper is different in that the focus is on conceptual issues and the research methods rather than the findings. Unlike positivist research, there is no accepted general model for communicating interpretive research. Similarly, few guidelines exist for conducting the inductive process central to interpretive research. Throughout the paper, issues relating to the choice and application of the methods in terms of conducting inductive research are discussed. Overall, the focus provides an in-depth discussion of the particular interpretive research that I undertook so that other researchers can read of an example that may be similar to their own and therefore guide their work.

  19. MpTheory Java library: a multi-platform Java library for systems biology based on the Metabolic P theory.

    Science.gov (United States)

    Marchetti, Luca; Manca, Vincenzo

    2015-04-15

    MpTheory Java library is an open-source project collecting a set of objects and algorithms for modeling observed dynamics by means of the Metabolic P (MP) theory, that is, a mathematical theory introduced in 2004 for modeling biological dynamics. By means of the library, it is possible to model biological systems both at continuous and at discrete time. Moreover, the library comprises a set of regression algorithms for inferring MP models starting from time series of observations. To enhance the modeling experience, beside a pure Java usage, the library can be directly used within the most popular computing environments, such as MATLAB, GNU Octave, Mathematica and R. The library is open-source and licensed under the GNU Lesser General Public License (LGPL) Version 3.0. Source code, binaries and complete documentation are available at http://mptheory.scienze.univr.it. luca.marchetti@univr.it, marchetti@cosbi.eu Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  20. Consolidity: Stack-based systems change pathway theory elaborated

    OpenAIRE

    Dorrah, Hassen Taher

    2014-01-01

    This paper presents an elaborated analysis for investigating the stack-based layering processes during the systems change pathway. The system change pathway is defined as the path resulting from the combinations of all successive changes induced on the system when subjected to varying environments, activities, events, or any excessive internal or external influences and happenings “on and above” its normal stands, situations or set-points during its course of life. The analysis is essentially...

  1. Advances in Statistical Control, Algebraic Systems Theory, and Dynamic Systems Characteristics A Tribute to Michael K Sain

    CERN Document Server

    Won, Chang-Hee; Michel, Anthony N

    2008-01-01

    This volume - dedicated to Michael K. Sain on the occasion of his seventieth birthday - is a collection of chapters covering recent advances in stochastic optimal control theory and algebraic systems theory. Written by experts in their respective fields, the chapters are thematically organized into four parts: Part I focuses on statistical control theory, where the cost function is viewed as a random variable and performance is shaped through cost cumulants. In this respect, statistical control generalizes linear-quadratic-Gaussian and H-infinity control. Part II addresses algebraic systems th

  2. How Decision Support Systems Can Benefit from a Theory of Change Approach

    Science.gov (United States)

    Allen, Will; Cruz, Jennyffer; Warburton, Bruce

    2017-06-01

    Decision support systems are now mostly computer and internet-based information systems designed to support land managers with complex decision-making. However, there is concern that many environmental and agricultural decision support systems remain underutilized and ineffective. Recent efforts to improve decision support systems use have focused on enhancing stakeholder participation in their development, but a mismatch between stakeholders' expectations and the reality of decision support systems outputs continues to limit uptake. Additional challenges remain in problem-framing and evaluation. We propose using an outcomes-based approach called theory of change in conjunction with decision support systems development to support both wider problem-framing and outcomes-based monitoring and evaluation. The theory of change helps framing by placing the decision support systems within a wider context. It highlights how decision support systems use can "contribute" to long-term outcomes, and helps align decision support systems outputs with these larger goals. We illustrate the benefits of linking decision support systems development and application with a theory of change approach using an example of pest rabbit management in Australia. We develop a theory of change that outlines the activities required to achieve the outcomes desired from an effective rabbit management program, and two decision support systems that contribute to specific aspects of decision making in this wider problem context. Using a theory of change in this way should increase acceptance of the role of decision support systems by end-users, clarify their limitations and, importantly, increase effectiveness of rabbit management. The use of a theory of change should benefit those seeking to improve decision support systems design, use and, evaluation.

  3. How Decision Support Systems Can Benefit from a Theory of Change Approach.

    Science.gov (United States)

    Allen, Will; Cruz, Jennyffer; Warburton, Bruce

    2017-06-01

    Decision support systems are now mostly computer and internet-based information systems designed to support land managers with complex decision-making. However, there is concern that many environmental and agricultural decision support systems remain underutilized and ineffective. Recent efforts to improve decision support systems use have focused on enhancing stakeholder participation in their development, but a mismatch between stakeholders' expectations and the reality of decision support systems outputs continues to limit uptake. Additional challenges remain in problem-framing and evaluation. We propose using an outcomes-based approach called theory of change in conjunction with decision support systems development to support both wider problem-framing and outcomes-based monitoring and evaluation. The theory of change helps framing by placing the decision support systems within a wider context. It highlights how decision support systems use can "contribute" to long-term outcomes, and helps align decision support systems outputs with these larger goals. We illustrate the benefits of linking decision support systems development and application with a theory of change approach using an example of pest rabbit management in Australia. We develop a theory of change that outlines the activities required to achieve the outcomes desired from an effective rabbit management program, and two decision support systems that contribute to specific aspects of decision making in this wider problem context. Using a theory of change in this way should increase acceptance of the role of decision support systems by end-users, clarify their limitations and, importantly, increase effectiveness of rabbit management. The use of a theory of change should benefit those seeking to improve decision support systems design, use and, evaluation.

  4. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    Science.gov (United States)

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-02

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure.

  5. Mechanical system reliability analysis using a combination of graph theory and Boolean function

    International Nuclear Information System (INIS)

    Tang, J.

    2001-01-01

    A new method based on graph theory and Boolean function for assessing reliability of mechanical systems is proposed. The procedure for this approach consists of two parts. By using the graph theory, the formula for the reliability of a mechanical system that considers the interrelations of subsystems or components is generated. Use of the Boolean function to examine the failure interactions of two particular elements of the system, followed with demonstrations of how to incorporate such failure dependencies into the analysis of larger systems, a constructive algorithm for quantifying the genuine interconnections between the subsystems or components is provided. The combination of graph theory and Boolean function provides an effective way to evaluate the reliability of a large, complex mechanical system. A numerical example demonstrates that this method an effective approaches in system reliability analysis

  6. Analysis of the Educational Personnel System: II. A Theory of Labor Mobility with Applications to the Teacher Market.

    Science.gov (United States)

    Greenberg, David; McCall, John

    This report, the second in a series of eight which analyzes the educational personnel system, applies three theories of labor mobility to primary and secondary school teachers. These theories are the economic theory of the human capital model, the institutional theory of internal labor markets, and a probabilistic Markov model. The literature on…

  7. Information Theory for Risk-based Water System Operation

    NARCIS (Netherlands)

    Weijs, S.V.

    2011-01-01

    Operational management of water resources needs predictions of future behavior of water systems, to anticipate shortage or excess of water in a timely manner. Because the natural systems that are part of the hydrological cycle are complex, the predictions inevitably are subject to considerable

  8. A Dynamic Systems Theory approach to second language acquisition

    NARCIS (Netherlands)

    de Bot, K.; Lowie, W.M.; Verspoor, M.H.

    In this article it is argued that language can be seen as a dynamic system, i.e. a set of variables that interact over time, and that language development can be seen as a dynamic process. Language development shows some of the core characteristics of dynamic systems: sensitive dependence on initial

  9. Positive dynamical systems in discrete time theory, models, and applications

    CERN Document Server

    Krause, Ulrich

    2015-01-01

    This book provides a systematic, rigorous and self-contained treatment of positive dynamical systems. A dynamical system is positive when all relevant variables of a systemare nonnegative in a natural way. This is in biology, demography or economics, where the levels of populations or prices of goods are positive. The principle also finds application in electrical engineering, physics and computer sciences.

  10. Designing modular manufacturing systems using mass customisation theories and methods

    DEFF Research Database (Denmark)

    Jørgensen, Steffen Nordahl; Hvilshøj, Mads; Madsen, Ole

    2012-01-01

    Today, manufacturing systems are developed as engineered to order (ETO) solutions tailored to produce a specific product or a limited product mix. However, such dedicated systems are not consistent with the current market demands for rapid product changes, high product variety, and customisation...

  11. Systems of innovation theory and the European Union

    DEFF Research Database (Denmark)

    Borras, Susana

    2004-01-01

    This article asks whether it is possible to conceptualise the European Union (EU) as a system of innovation in accordance with the rich literature of institutional economics on these matters. By developing four further theoretical nodal points of the system of innovation concept, an analytical...

  12. A Novel Theory for Sample Data System Passivity

    NARCIS (Netherlands)

    Stramigioli, S.; Secchi, C.; Schaft, A.J. van der; Fantuzzi, C.

    2002-01-01

    This paper presents a novel way to approach the interconnection of a continuous time and a discrete time physical system. This is done in a way which preserve passivity of the coupled system independently of the sampling time T. A direct application is in the field of haptic displays where virtual

  13. ENVIRONMENTAL SYSTEMS MANAGEMENT, SUSTAINABILITY THEORY, AND THE CHALLENGE OF UNCERTAINTY

    Science.gov (United States)

    Environmental Systems Management is the management of environmental problems at the systems level fully accounting fo rthe multi-dimensional nature of the environment. This includes socio-economic dimensions as well s the usual physical and life science aspects. This is important...

  14. Coherent versus Measurement Feedback: Linear Systems Theory for Quantum Information

    Directory of Open Access Journals (Sweden)

    Naoki Yamamoto

    2014-11-01

    Full Text Available To control a quantum system via feedback, we generally have two options in choosing a control scheme. One is the coherent feedback, which feeds the output field of the system, through a fully quantum device, back to manipulate the system without involving any measurement process. The other one is measurement-based feedback, which measures the output field and performs a real-time manipulation on the system based on the measurement results. Both schemes have advantages and disadvantages, depending on the system and the control goal; hence, their comparison in several situations is important. This paper considers a general open linear quantum system with the following specific control goals: backaction evasion, generation of a quantum nondemolished variable, and generation of a decoherence-free subsystem, all of which have important roles in quantum information science. Some no-go theorems are proven, clarifying that those goals cannot be achieved by any measurement-based feedback control. On the other hand, it is shown that, for each control goal there exists a coherent feedback controller accomplishing the task. The key idea to obtain all the results is system theoretic characterizations of the above three notions in terms of controllability and observability properties or transfer functions of linear systems, which are consistent with their standard definitions.

  15. Applications of General Systems Theory to the Development of an Adjustable Tutorial Software Machine.

    Science.gov (United States)

    Vos, Hans J.

    1994-01-01

    Describes the construction of a model of computer-assisted instruction using a qualitative block diagram based on general systems theory (GST) as a framework. Subject matter representation is discussed, and appendices include system variables and system equations of the GST model, as well as an example of developing flexible courseware. (Contains…

  16. Predictive modeling of coupled multi-physics systems: I. Theory

    International Nuclear Information System (INIS)

    Cacuci, Dan Gabriel

    2014-01-01

    Highlights: • We developed “predictive modeling of coupled multi-physics systems (PMCMPS)”. • PMCMPS reduces predicted uncertainties in predicted model responses and parameters. • PMCMPS treats efficiently very large coupled systems. - Abstract: This work presents an innovative mathematical methodology for “predictive modeling of coupled multi-physics systems (PMCMPS).” This methodology takes into account fully the coupling terms between the systems but requires only the computational resources that would be needed to perform predictive modeling on each system separately. The PMCMPS methodology uses the maximum entropy principle to construct an optimal approximation of the unknown a priori distribution based on a priori known mean values and uncertainties characterizing the parameters and responses for both multi-physics models. This “maximum entropy”-approximate a priori distribution is combined, using Bayes’ theorem, with the “likelihood” provided by the multi-physics simulation models. Subsequently, the posterior distribution thus obtained is evaluated using the saddle-point method to obtain analytical expressions for the optimally predicted values for the multi-physics models parameters and responses along with corresponding reduced uncertainties. Noteworthy, the predictive modeling methodology for the coupled systems is constructed such that the systems can be considered sequentially rather than simultaneously, while preserving exactly the same results as if the systems were treated simultaneously. Consequently, very large coupled systems, which could perhaps exceed available computational resources if treated simultaneously, can be treated with the PMCMPS methodology presented in this work sequentially and without any loss of generality or information, requiring just the resources that would be needed if the systems were treated sequentially

  17. Risk Modeling of Interdependent Complex Systems of Systems: Theory and Practice.

    Science.gov (United States)

    Haimes, Yacov Y

    2018-01-01

    The emergence of the complexity characterizing our systems of systems (SoS) requires a reevaluation of the way we model, assess, manage, communicate, and analyze the risk thereto. Current models for risk analysis of emergent complex SoS are insufficient because too often they rely on the same risk functions and models used for single systems. These models commonly fail to incorporate the complexity derived from the networks of interdependencies and interconnectedness (I-I) characterizing SoS. There is a need to reevaluate currently practiced risk analysis to respond to this reality by examining, and thus comprehending, what makes emergent SoS complex. The key to evaluating the risk to SoS lies in understanding the genesis of characterizing I-I of systems manifested through shared states and other essential entities within and among the systems that constitute SoS. The term "essential entities" includes shared decisions, resources, functions, policies, decisionmakers, stakeholders, organizational setups, and others. This undertaking can be accomplished by building on state-space theory, which is fundamental to systems engineering and process control. This article presents a theoretical and analytical framework for modeling the risk to SoS with two case studies performed with the MITRE Corporation and demonstrates the pivotal contributions made by shared states and other essential entities to modeling and analysis of the risk to complex SoS. A third case study highlights the multifarious representations of SoS, which require harmonizing the risk analysis process currently applied to single systems when applied to complex SoS. © 2017 Society for Risk Analysis.

  18. Utilizing the language of Jean Watson's caring theory within a computerized clinical documentation system.

    Science.gov (United States)

    Rosenberg, Susan

    2006-01-01

    The healthcare facility described in the following article is part of an eight-hospital organization that adopted Watson's Theory of Caring as part of their nursing philosophy. According to Watson, this theory is an attempt to find and deepen the language specific to nurse caring relations and its many meanings. Yet during the implementation of the theory within the setting described, it was noted that there was no mechanism in the current documentation system for clinical nursing staff to document the patient experience using any language specific to the theory. Nursing members recognized an opportunity to develop a new context in charting during an extensive clinical documentation system upgrade. A discussion of the steps taken and the results within the clinical documentation system supporting the newly adopted caring philosophy are summarized here.

  19. Theory of optical transitions in conjugated polymers. I. Ideal systems.

    Science.gov (United States)

    Barford, William; Marcus, Max

    2014-10-28

    We describe a theory of linear optical transitions in conjugated polymers. The theory is based on three assumptions. The first is that the low-lying excited states of conjugated polymers are Frenkel excitons coupled to local normal modes, described by the Frenkel-Holstein model. Second, we assume that the relevant parameter regime is ℏω ≪ J, i.e., the adiabatic regime, and thus the Born-Oppenheimer factorization of the electronic and nuclear degrees of freedom is generally applicable. Finally, we assume that the Condon approximation is valid, i.e., the exciton-polaron wavefunction is essentially independent of the normal modes. Using these assumptions we derive an expression for an effective Huang-Rhys parameter for a chain (or chromophore) of N monomers, given by S(N) = S(1)/IPR, where S(1) is the Huang-Rhys parameter for an isolated monomer. IPR is the inverse participation ratio, defined by IPR = (∑(n)|Ψ(n)|(4))(-1), where Ψ(n) is the exciton center-of-mass wavefunction. Since the IPR is proportional to the spread of the exciton center-of-mass wavefunction, this is a key result, as it shows that S(N) decreases with chain length. As in molecules, in a polymer S(N) has two interpretations. First, ℏωS(N) is the relaxation energy of an excited state caused by its coupling to the normal modes. Second, S(N) appears in the definition of an effective Franck-Condon factor, F(0v)(N) = S(N)(v)exp ( - S(N))/v! for the vth vibronic manifold. We show that the 0 - 0 and 0 - 1 optical intensities are proportional to F00(N) and F01(N), respectively, and thus the ratio of the 0 - 1 to 0 - 0 absorption and emission intensities are proportional to S(N). These analytical results are checked by extensive DMRG calculations and found to be generally valid, particularly for emission. However, for large chain lengths higher-lying quasimomentum exciton states become degenerate with the lowest vibrational excitation of the lowest exciton state. When this happens there is

  20. Monte Carlo Techniques for Nuclear Systems - Theory Lectures

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Forrest B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Monte Carlo Methods, Codes, and Applications Group; Univ. of New Mexico, Albuquerque, NM (United States). Nuclear Engineering Dept.

    2016-11-29

    These are lecture notes for a Monte Carlo class given at the University of New Mexico. The following topics are covered: course information; nuclear eng. review & MC; random numbers and sampling; computational geometry; collision physics; tallies and statistics; eigenvalue calculations I; eigenvalue calculations II; eigenvalue calculations III; variance reduction; parallel Monte Carlo; parameter studies; fission matrix and higher eigenmodes; doppler broadening; Monte Carlo depletion; HTGR modeling; coupled MC and T/H calculations; fission energy deposition. Solving particle transport problems with the Monte Carlo method is simple - just simulate the particle behavior. The devil is in the details, however. These lectures provide a balanced approach to the theory and practice of Monte Carlo simulation codes. The first lectures provide an overview of Monte Carlo simulation methods, covering the transport equation, random sampling, computational geometry, collision physics, and statistics. The next lectures focus on the state-of-the-art in Monte Carlo criticality simulations, covering the theory of eigenvalue calculations, convergence analysis, dominance ratio calculations, bias in Keff and tallies, bias in uncertainties, a case study of a realistic calculation, and Wielandt acceleration techniques. The remaining lectures cover advanced topics, including HTGR modeling and stochastic geometry, temperature dependence, fission energy deposition, depletion calculations, parallel calculations, and parameter studies. This portion of the class focuses on using MCNP to perform criticality calculations for reactor physics and criticality safety applications. It is an intermediate level class, intended for those with at least some familiarity with MCNP. Class examples provide hands-on experience at running the code, plotting both geometry and results, and understanding the code output. The class includes lectures & hands-on computer use for a variety of Monte Carlo calculations

  1. Impact of Child Maltreatment on Attachment and Social Rank Systems: Introducing an Integrated Theory.

    Science.gov (United States)

    Sloman, Leon; Taylor, Peter

    2016-04-01

    Child maltreatment is a prevalent societal problem that has been linked to a wide range of social, psychological, and emotional difficulties. Maltreatment impacts on two putative evolved psychobiological systems in particular, the attachment system and the social rank system. The maltreatment may disrupt the child's ability to form trusting and reassuring relationships and also creates a power imbalance where the child may feel powerless and ashamed. The aim of the current article is to outline an evolutionary theory for understanding the impact of child maltreatment, focusing on the interaction between the attachment and the social rank system. We provide a narrative review of the relevant literature relating to child maltreatment and these two theories. This research highlights how, in instances of maltreatment, these ordinarily adaptive systems may become maladaptive and contribute to psychopathology. We identify a number of novel hypotheses that can be drawn from this theory, providing a guide for future research. We finally explore how this theory provides a guide for the treatment of victims of child maltreatment. In conclusion, the integrated theory provides a framework for understanding and predicting the consequences of maltreatment, but further research is required to test several hypotheses made by this theory. © The Author(s) 2015.

  2. Bridging developmental systems theory and evolutionary psychology using dynamic optimization.

    Science.gov (United States)

    Frankenhuis, Willem E; Panchanathan, Karthik; Clark Barrett, H

    2013-07-01

    Interactions between evolutionary psychologists and developmental systems theorists have been largely antagonistic. This is unfortunate because potential synergies between the two approaches remain unexplored. This article presents a method that may help to bridge the divide, and that has proven fruitful in biology: dynamic optimization. Dynamic optimization integrates developmental systems theorists' focus on dynamics and contingency with the 'design stance' of evolutionary psychology. It provides a theoretical framework as well as a set of tools for exploring the properties of developmental systems that natural selection might favor, given particular evolutionary ecologies. We also discuss limitations of the approach. © 2013 Blackwell Publishing Ltd.

  3. Small collision systems: Theory overview on cold nuclear matter effects

    Directory of Open Access Journals (Sweden)

    Armesto Néstor

    2018-01-01

    Full Text Available Many observables measured at the Relativistic Heavy Ion Collider and the Large Hadron Collider show a smooth transition between proton-proton and protonnucleus collisions (small systems, and nucleus-nucleus collisions (large systems, when represented versus some variable like the multiplicity in the event. In this contribution I review some of the physics mechanisms, named cold nuclear matter effects, that may lead to a collective-like behaviour in small systems beyond the macroscopic description provided by relativistic hydrodynamics. I focus on the nuclear modification of parton densities, single inclusive particle production and correlations.

  4. Small collision systems: Theory overview on cold nuclear matter effects

    Science.gov (United States)

    Armesto, Néstor

    2018-02-01

    Many observables measured at the Relativistic Heavy Ion Collider and the Large Hadron Collider show a smooth transition between proton-proton and protonnucleus collisions (small systems), and nucleus-nucleus collisions (large systems), when represented versus some variable like the multiplicity in the event. In this contribution I review some of the physics mechanisms, named cold nuclear matter effects, that may lead to a collective-like behaviour in small systems beyond the macroscopic description provided by relativistic hydrodynamics. I focus on the nuclear modification of parton densities, single inclusive particle production and correlations.

  5. Bridging developmental systems theory and evolutionary psychology using dynamic optimization

    NARCIS (Netherlands)

    Frankenhuis, W.E.; Panchanathan, K.; Barrett, H.C.

    2013-01-01

    Interactions between evolutionary psychologists and developmental systems theorists have been largely antagonistic. This is unfortunate because potential synergies between the two approaches remain unexplored. This article presents a method that may help to bridge the divide, and that has proven

  6. THEORY METODOLOGICAL BASIS OF LOCAL SYSTEMS OF CORPORATIVE ENTERPRISE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    N.A. Pytkin

    2007-03-01

    Full Text Available The urgency of corporate governance systems research is caused by apparently not complete realization of these systems in the modern practice as only in an insignificant degree considers peculiarities of each single company and relies, first of all, on the experience of base systems of corporate governance in general. Such approach results in a bunch of negative effects, including formal realization of requirements of "corporate governance codes" and other similar documents. In this connection we offer the approach to designing effective local systems of corporate governance (LSCG which would consider not only the existing recommendations on corporate governance, but also the greatest possible set of external and internal factors for every separate company. This article is devoted to theoretical bases of LSCG.

  7. Innovations in pricing of transportation systems : theory and practice.

    Science.gov (United States)

    2011-08-15

    This report summarizes results from the conference titled Innovations in Pricing of : Transportation Systems on May 12 14, 2010 at the Royal Plaza Hotel in Orlando, Florida. : The primary objective of the conference is to bring together pra...

  8. Category Theory as a Formal Mathematical Foundation for Model-Based Systems Engineering

    KAUST Repository

    Mabrok, Mohamed

    2017-01-09

    In this paper, we introduce Category Theory as a formal foundation for model-based systems engineering. A generalised view of the system based on category theory is presented, where any system can be considered as a category. The objects of the category represent all the elements and components of the system and the arrows represent the relations between these components (objects). The relationship between these objects are the arrows or the morphisms in the category. The Olog is introduced as a formal language to describe a given real-world situation description and requirement writing. A simple example is provided.

  9. Towards a large deviation theory for strongly correlated systems

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, Guiomar, E-mail: guiomar.ruiz@upm.es [Centro Brasileiro de Pesquisas Fisicas and National Institute of Science and Technology for Complex Systems, Rua Xavier Sigaud 150, 22290-180 Rio de Janeiro, RJ (Brazil); Departamento de Matemática Aplicada y Estadística, Universidad Politécnica de Madrid, Pza. Cardenal Cisneros s.n., 28040 Madrid (Spain); Tsallis, Constantino, E-mail: tsallis@cbpf.br [Centro Brasileiro de Pesquisas Fisicas and National Institute of Science and Technology for Complex Systems, Rua Xavier Sigaud 150, 22290-180 Rio de Janeiro, RJ (Brazil); Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501 (United States)

    2012-07-23

    A large-deviation connection of statistical mechanics is provided by N independent binary variables, the (N→∞) limit yielding Gaussian distributions. The probability of n≠N/2 out of N throws is governed by e{sup −Nr}, r related to the entropy. Large deviations for a strong correlated model characterized by indices (Q,γ) are studied, the (N→∞) limit yielding Q-Gaussians (Q→1 recovers a Gaussian). Its large deviations are governed by e{sub q}{sup −Nr{sub q}} (∝1/N{sup 1/(q−1)}, q>1), q=(Q−1)/(γ[3−Q])+1. This illustration opens the door towards a large-deviation foundation of nonextensive statistical mechanics. -- Highlights: ► We introduce the formalism of relative entropy for a single random binary variable and its q-generalization. ► We study a model of N strongly correlated binary random variables and their large-deviation probabilities. ► Large-deviation probability of strongly correlated model exhibits a q-exponential decay whose argument is proportional to N, as extensivity requires. ► Our results point to a q-generalized large deviation theory and suggest a large-deviation foundation of nonextensive statistical mechanics.

  10. Biomimetic model systems of rigid hair beds: Part I - Theory

    Science.gov (United States)

    Hood, Kaitlyn; Jammalamadaka, Mani S. S.; Hosoi, Anette

    2017-11-01

    Crustaceans - such as lobsters, crabs, and stomapods - have hairy appendages that they use to recognize and track odorants in the surrounding fluid. An array of rigid hairs impedes flow at different rates depending on the spacing between hairs and the Reynolds number, Re. At larger Reynolds numbers (Re >1), fluid travels through the hairs rather than around them, a phenomenon called leakiness. Crustaceans flick their appendages at different speeds in order to manipulate the leakiness between the hairs, allowing the hairs to either detect odors in a sample of fluid or collect a new sample. A single hair can be represented as a slender body attached at one end to a wall. Using both slender body theory and numerical methods, we observe that there is a region of flow around the hair that speeds up relative to the unobstructed flow. As the Reynolds number increases, this fast flow region moves closer to the hair. Using this model, we predict that an array of hairs can be engineered to have a desired leakiness profile.

  11. Consolidity: Stack-based systems change pathway theory elaborated

    Directory of Open Access Journals (Sweden)

    Hassen Taher Dorrah

    2014-06-01

    Full Text Available This paper presents an elaborated analysis for investigating the stack-based layering processes during the systems change pathway. The system change pathway is defined as the path resulting from the combinations of all successive changes induced on the system when subjected to varying environments, activities, events, or any excessive internal or external influences and happenings “on and above” its normal stands, situations or set-points during its course of life. The analysis is essentially based on the important overall system paradigm of “Time driven-event driven-parameters change”. Based on this paradigm, it is considered that any affected activity, event or varying environment is intelligently self-recorded inside the system through an incremental consolidity-scaled change in system parameters of the stack-based layering types. Various joint stack-based mathematical and graphical approaches supported by representable case studies are suggested for the identification, extraction, and processing of various stack-based systems changes layering of different classifications and categorizations. Moreover, some selected real life illustrative applications are provided to demonstrate the (infinite stack-based identification and recognition of the change pathway process in the areas of geology, archeology, life sciences, ecology, environmental science, engineering, materials, medicine, biology, sociology, humanities, and other important fields. These case studies and selected applications revealed that there are general similarities of the stack-based layering structures and formations among all the various research fields. Such general similarities clearly demonstrate the global concept of the “fractals-general stacking behavior” of real life systems during their change pathways. Therefore, it is recommended that concentrated efforts should be expedited toward building generic modular stack-based systems or blocks for the mathematical

  12. Neural multigrid for gauge theories and other disordered systems

    International Nuclear Information System (INIS)

    Baeker, M.; Kalkreuter, T.; Mack, G.; Speh, M.

    1992-09-01

    We present evidence that multigrid works for wave equations in disordered systems, e.g. in the presence of gauge fields, no matter how strong the disorder, but one needs to introduce a 'neural computations' point of view into large scale simulations: First, the system must learn how to do the simulations efficiently, then do the simulation (fast). The method can also be used to provide smooth interpolation kernels which are needed in multigrid Monte Carlo updates. (orig.)

  13. Application of Hybrid Dynamical Theory to the Cardiovascular System

    KAUST Repository

    Laleg-Kirati, Taous-Meriem

    2014-10-14

    In hybrid dynamical systems, the state evolves in continuous time as well as in discrete modes activated by internal conditions or by external events. In the recent years, hybrid systems modeling has been used to represent the dynamics of biological systems. In such systems, discrete behaviors might originate from unexpected changes in normal performance, e.g., a transition from a healthy to an abnormal condition. Simplifications, model assumptions, and/or modeled (and ignored) nonlinearities can be represented by sudden changes in the state. Modeling cardiovascular system (CVS), one of the most fascinating but most complex human physiological systems, with a hybrid approach, is the focus of this chapter. The hybrid property appears naturally in the CVS thanks to the presence of valves which, depending on their state (closed or open), divide the cardiac cycle into four phases. This chapter shows how hybrid models can be used for modeling the CVS. In addition, it describes a preliminary study on the detection of some cardiac anomalies based on the hybrid model and using the standard observer-based approach.

  14. [Social institutions and tempering of affects as "contraints" of social change. Norbert Elias' theory on the civilization theory in light of the biologic system theory of evolution].

    Science.gov (United States)

    Weinich, Detlef

    2005-01-01

    This study is to be regarded as a contribution to interdisciplinary research and represents an attempt to clarify the question of whether and to what extent concepts that have been developed in the field of theoretical biology and which have a high degree of importance here can also be applied to sociological phenomena. In particular it is intended to examine the question of whether the civilizing process can be adequately treated using the evolutionary concept of "Constraints". This term, which has only recently been introduced into the discussion by PERE ALBERCH as an evolutionary factor, comprises all of the internal factors which influence the further course of the evolution of a system by ruling out certain possibilities, thus showing a limiting effect. Although "Constraints" go beyond the scope of Darwinian teachings about selection by the environment, they are increasingly accepted today as evolution factors by well-known exponents of Darwinian theory (cf. MAYNARD-SMITH 1985). The increase in popularity of "constraints" is also an expression of the rediscovery of a phenomenon which was originally expressed by RUPERT RIEDL and was introduced by him into German literature in the seventies. In the clarification of this question, special reference is made to the "theory of the civilizing process" by NORBERT ELIAS, since here a highly respected scholar has presented an important sociological theory. Moreover, there is such good scientific access to ELIAS because this author exemplifies his theses in historical terms and thus to a certain extent makes his explanations verifiable in scientific terms. In the treatment of this topic, the central terms and theses of ELIAS will be presented from the considerable scope of his work, and then illustrated with the help of several selected historical case studies. Furthermore, reference will be made at the relevant points to parallels and analogies which the works of ELIAS have to other, predominantly system

  15. Nobel Prize 1992: Rudolph A. Marcus: theory of electron transfer reactions in chemical systems

    International Nuclear Information System (INIS)

    Ulate Segura, Diego Guillermo

    2011-01-01

    A review of the theory developed by Rudolph A. Marcus is presented, who for his rating to the theory of electron transfer in chemical systems was awarded the Nobel Prize in Chemistry in 1992. Marcus theory has constituted not only a good extension of the use of a spectroscopic principle, but also has provided an energy balance and the application of energy conservation for electron transfer reactions. A better understanding of the reaction coordinate is exposed in terms energetic and establishing the principles that govern the transfer of electrons, protons and some labile small molecular groups as studied at present. Also, the postulates and equations described have established predictive models of reaction time, very useful for industrial environments, biological, metabolic, and others that involve redox processes. Marcus theory itself has also constituted a large contribution to the theory of complex transition [es

  16. Linear systems formulation of scattering theory for rough surfaces with arbitrary incident and scattering angles.

    Science.gov (United States)

    Krywonos, Andrey; Harvey, James E; Choi, Narak

    2011-06-01

    Scattering effects from microtopographic surface roughness are merely nonparaxial diffraction phenomena resulting from random phase variations in the reflected or transmitted wavefront. Rayleigh-Rice, Beckmann-Kirchhoff. or Harvey-Shack surface scatter theories are commonly used to predict surface scatter effects. Smooth-surface and/or paraxial approximations have severely limited the range of applicability of each of the above theoretical treatments. A recent linear systems formulation of nonparaxial scalar diffraction theory applied to surface scatter phenomena resulted first in an empirically modified Beckmann-Kirchhoff surface scatter model, then a generalized Harvey-Shack theory that produces accurate results for rougher surfaces than the Rayleigh-Rice theory and for larger incident and scattered angles than the classical Beckmann-Kirchhoff and the original Harvey-Shack theories. These new developments simplify the analysis and understanding of nonintuitive scattering behavior from rough surfaces illuminated at arbitrary incident angles.

  17. Serum Biochemical Phenotypes in the Domestic Dog.

    Directory of Open Access Journals (Sweden)

    Yu-Mei Chang

    Full Text Available The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phenotypes have been documented in the domestic dog, but little has been published on serum biochemical phenotypes in this species. Serum biochemical profiles of dogs in which all measurements fell within the existing reference intervals were retrieved from a large veterinary database. Serum biochemical profiles from 3045 dogs were retrieved, of which 1495 had an accompanying normal glucose concentration. Sixty pure breeds plus a mixed breed control group were represented by at least 10 individuals. All analytes, except for sodium, chloride and glucose, showed variation with age. Total protein, globulin, potassium, chloride, creatinine, cholesterol, total bilirubin, ALT, CK, amylase, and lipase varied between sexes. Neutering status significantly impacted all analytes except albumin, sodium, calcium, urea, and glucose. Principal component analysis of serum biochemical data revealed 36 pure breeds with distinctive phenotypes. Furthermore, comparative analysis identified 23 breeds with significant differences from the mixed breed group in all biochemical analytes except urea and glucose. Eighteen breeds were identified by both principal component and comparative analysis. Tentative reference intervals were generated for breeds with a distinctive phenotype identified by comparative analysis and represented by at least 120 individuals. This is the first large-scale analysis of breed-specific serum biochemical phenotypes in the domestic dog and highlights potential genetic components of biochemical traits in this species.

  18. Calculation of local excitations in large systems by embedding wave-function theory in density-functional theory.

    Science.gov (United States)

    Gomes, André Severo Pereira; Jacob, Christoph R; Visscher, Lucas

    2008-09-21

    We present a simple and efficient embedding scheme for the wave-function based calculation of the energies of local excitations in large systems. By introducing an embedding potential obtained from density-functional theory (DFT) it is possible to describe the effect of an environment on local excitations of an embedded system in wave-function theory (WFT) calculations of the excitation energies. We outline the implementation of such a WFT-in-DFT embedding procedure employing the ADF, Dalton and DIRAC codes, where the embedded subsystem is treated with coupled cluster methods. We then evaluate this procedure in the calculation of the solvatochromic shift of acetone in water and of the f-f spectrum of NpO22+ embedded in a Cs2UO2Cl4 crystal and find that our scheme does effectively incorporate the environment effect in both cases. A particularly interesting finding is that with our embedding scheme we can model the equatorial Cl- ligands in NpO2Cl42- quite accurately, compared to a fully wavefunction-based calculation, and this opens up the possibility of modeling the interaction of different ligands to actinyl species with relatively high accuracy but at a much reduced computational cost.

  19. New Concepts and Theories For Intelligent Control of Cellular Manufacturing Systems

    DEFF Research Database (Denmark)

    Langer, Gilad

    1996-01-01

    This paper will present some new theories such as biological manufacturing system, the fractal factory theory, holonic manufacturing systems, agile manufacturing, object orientation, multi-agent theory, artificial intelligence, and artificial life in the context of manufacturing systems....... The paper tries to encapsulate the main area of my Ph.D. thesis research which will evolve around the idea of integrating intelligent elements into the control systems of the manufacturing systems. Furthermore it intends to show how the curriculum and discussions of the IPS Ph.D. course will and have...... contributed to my research. The research will concentrate on integration of manufacturing units by use of intelligent control mechanisms, information technology and the material handling as the key integrators....

  20. Stochastic Neural Field Theory and the System-Size Expansion

    KAUST Repository

    Bressloff, Paul C.

    2010-01-01

    We analyze a master equation formulation of stochastic neurodynamics for a network of synaptically coupled homogeneous neuronal populations each consisting of N identical neurons. The state of the network is specified by the fraction of active or spiking neurons in each population, and transition rates are chosen so that in the thermodynamic or deterministic limit (N → ∞) we recover standard activity-based or voltage-based rate models. We derive the lowest order corrections to these rate equations for large but finite N using two different approximation schemes, one based on the Van Kampen system-size expansion and the other based on path integral methods. Both methods yield the same series expansion of the moment equations, which at O(1/N) can be truncated to form a closed system of equations for the first-and second-order moments. Taking a continuum limit of the moment equations while keeping the system size N fixed generates a system of integrodifferential equations for the mean and covariance of the corresponding stochastic neural field model. We also show how the path integral approach can be used to study large deviation or rare event statistics underlying escape from the basin of attraction of a stable fixed point of the mean-field dynamics; such an analysis is not possible using the system-size expansion since the latter cannot accurately determine exponentially small transitions. © by SIAM.

  1. Dose dependency and individual variability in selected clinical, haematological and blood biochemical responses after systemic lipopolysaccharide challenge in cattle

    DEFF Research Database (Denmark)

    Jacobsen, Stine; Tølbøll, Trine; Andersen, Pia Haubro Fischer

    2005-01-01

    Previous studies have notede that susceptibility to systemic lipopolysaccharide (LPS) exposure seems to differ between individual cows. However, to date inter-individual variation in the existence or extent has never been backed up by statistical analyses.......Previous studies have notede that susceptibility to systemic lipopolysaccharide (LPS) exposure seems to differ between individual cows. However, to date inter-individual variation in the existence or extent has never been backed up by statistical analyses....

  2. Topics in the theory of heavy-quark systems

    International Nuclear Information System (INIS)

    Flory, C.A.

    1981-04-01

    Due to the kinematic and dynamic simplifications possible because of the large mass of heavy quark bound states, certain properties of these systems can be quantitatively analyzed within the framework of quantum chromodynamics. It is clear that dimensionally the size of the bound state is proportional to the inverse quark mass, and for very heavy quarkonia the radius of the system should become smaller than that of normal hadrons. When this small system interacts with external long wavelength field quanta, the natural expansion that results is of a multipole type, analogous to the familiar multipole expansion in electrodynamics. This multipole expansion has better convergence properties than the standard perturbative treatment in certain kinematic regimes, which opens up a new area for strong interaction physics calculations. More specifically, it is ideally suited to investigate soft non-perturbative effects in QCD which appear to be so crucial to present day phenomenology and the conjectured confinement mechanism

  3. Complex fluids in biological systems experiment, theory, and computation

    CERN Document Server

    2015-01-01

    This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solut...

  4. Rabi resonance in spin systems: theory and experiment.

    Science.gov (United States)

    Layton, Kelvin J; Tahayori, Bahman; Mareels, Iven M Y; Farrell, Peter M; Johnston, Leigh A

    2014-05-01

    The response of a magnetic resonance spin system is predicted and experimentally verified for the particular case of a continuous wave amplitude modulated radiofrequency excitation. The experimental results demonstrate phenomena not previously observed in magnetic resonance systems, including a secondary resonance condition when the amplitude of the excitation equals the modulation frequency. This secondary resonance produces a relatively large steady state magnetisation with Fourier components at harmonics of the modulation frequency. Experiments are in excellent agreement with the theoretical prediction derived from the Bloch equations, which provides a sound theoretical framework for future developments in NMR spectroscopy and imaging. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Towards a theory of integrity systems: a configurational approach

    NARCIS (Netherlands)

    Six, F.E.; Lawton, A.

    2013-01-01

    The integrity of public officials is considered a key determinant of public trust in government and a central concept in good governance. An integrity system consists of all components, such as policies, practices, institutions and integrity guardians meant to contribute to the integrity of the

  6. Leadership Theory for School Psychologists: Leading for Systems Change

    Science.gov (United States)

    Burns, Matthew K.; Preast, June L.; Kilpatrick, Kayla D.; Taylor, Crystal N.; Young, Helen; Aguilar, Lisa; Allen, Amanda; Copeland, Christa; Haider, Aqdas; Henry, Lauren

    2017-01-01

    School psychologists are often seen as leaders in schools. They lead data teams, problem-solving teams, multidisciplinary evaluation teams, and crisis response teams. They are also perceived as leaders regarding intervention, multitiered systems of support, behavior support, collaboration, consultation, special education, assessment, and…

  7. Towards a General Theory of Stochastic Hybrid Systems

    NARCIS (Netherlands)

    Bujorianu, L.M.; Lygeros, J.; Bujorianu, M.C.

    2008-01-01

    In this paper we set up a mathematical structure, called Markov string, to obtaining a very general class of models for stochastic hybrid systems. Markov Strings are, in fact, a class of Markov processes, obtained by a mixing mechanism of stochastic processes, introduced by Meyer. We prove that

  8. World system theory and keynesian macroeconomics: towards an ...

    African Journals Online (AJOL)

    Such a mobilisation will not, however, threaten the income and employment position of workers in the North, via the demands and higher competitiveness of workers from the South, as differences in labour costs are mediated through the exchange rate. Keywords : Capitalist world system, grouwth, less developped countries ...

  9. Control Engineering, System Theory and Mathematics: The Teacher's Challenge

    Science.gov (United States)

    Zenger, K.

    2007-01-01

    The principles, difficulties and challenges in control education are discussed and compared to the similar problems in the teaching of mathematics and systems science in general. The difficulties of today's students to appreciate the classical teaching of engineering disciplines, which are based on rigorous and scientifically sound grounds, are…

  10. Quadratic theory and feedback controllers for linear time delay systems

    International Nuclear Information System (INIS)

    Lee, E.B.

    1976-01-01

    Recent research on the design of controllers for systems having time delays is discussed. Results for the ''open loop'' and ''closed loop'' designs will be presented. In both cases results for minimizing a quadratic cost functional are given. The usefulness of these results is not known, but similar results for the non-delay case are being routinely applied. (author)

  11. Bridging Developmental Systems Theory and Evolutionary Psychology Using Dynamic Optimization

    Science.gov (United States)

    Frankenhuis, Willem E.; Panchanathan, Karthik; Clark Barrett, H.

    2013-01-01

    Interactions between evolutionary psychologists and developmental systems theorists have been largely antagonistic. This is unfortunate because potential synergies between the two approaches remain unexplored. This article presents a method that may help to bridge the divide, and that has proven fruitful in biology: dynamic optimization. Dynamic…

  12. Toward a General Theory of Stochastic Hybrid Systems

    NARCIS (Netherlands)

    Bujorianu, L.M.; Lygeros, J.; Blom, H.A.P.; Lygeros, J.

    In this chapter we set up a mathematical structure, called Markov string, to obtaining a very general class of models for stochastic hybrid systems. Markov Strings are, in fact, a class of Markov processes, obtained by a mixing mechanism of stochastic processes, introduced by Meyer. We prove that

  13. Economic Decision Making: Application of the Theory of Complex Systems

    Science.gov (United States)

    Kitt, Robert

    In this chapter the complex systems are discussed in the context of economic and business policy and decision making. It will be showed and motivated that social systems are typically chaotic, non-linear and/or non-equilibrium and therefore complex systems. It is discussed that the rapid change in global consumer behaviour is underway, that further increases the complexity in business and management. For policy making under complexity, following principles are offered: openness and international competition, tolerance and variety of ideas, self-reliability and low dependence on external help. The chapter contains four applications that build on the theoretical motivation of complexity in social systems. The first application demonstrates that small economies have good prospects to gain from the global processes underway, if they can demonstrate production flexibility, reliable business ethics and good risk management. The second application elaborates on and discusses the opportunities and challenges in decision making under complexity from macro and micro economic perspective. In this environment, the challenges for corporate management are being also permanently changed: the balance between short term noise and long term chaos whose attractor includes customers, shareholders and employees must be found. The emergence of chaos in economic relationships is demonstrated by a simple system of differential equations that relate the stakeholders described above. The chapter concludes with two financial applications: about debt and risk management. The non-equilibrium economic establishment leads to additional problems by using excessive borrowing; unexpected downturns in economy can more easily kill companies. Finally, the demand for quantitative improvements in risk management is postulated. Development of the financial markets has triggered non-linearity to spike in prices of various production articles such as agricultural and other commodities that has added market

  14. Cancer-affine radiopharmaceuticals for the study of biochemical nature of cancer and in the early diagnosis and follow-up of cancer and its systemic therapy

    International Nuclear Information System (INIS)

    Shukla, S.K.; Cipriani, C.; Atzei, G.

    1998-01-01

    Cancer patient needs less diagnosis but an effective therapy. The systemic nature of cancer, often right from its inception, requires systemic therapy with cancer-affine radiopharmaceuticals which contain radionuclide species recognizing both the primary and secondary cancers which have generally different biochemical properties. Cancers may be classified into two groups: I. CATIONIC COMPLEX-AFFINE TUMOURS; Lung cancer, thyroid cancer, primary breast cancer, renal cell carcinoma, bone metastases from anionic complex-affine cancers, ...; II. ANIONIC COMPLEX-AFFINE TUMOURS; Primary prostate cancer, melanoma, hepatocellular carcinoma, osteosarcoma, Ewing's sarcoma, bone metastases from cationic complex-affine cancer. With cancer-affine citratogallate-67 complexes we have diagnosed and followed up, and with citratoyttrate-90 complexes we have treated advanced breast, prostate, renal cell cancer patients. The patient preparation by advising to avoid cancer risk factors and to take cancer preventing and radiopharmaceutical stabilizing diets during diagnosis and therapy have given better results. Friendliness, caring visits and telephone calls from the therapist group help to obtain better outcomes of the diagnosis, and mainly of the therapy. The complexes of these radionuclides with other chelating agents EDTA and DPTA are expected to give better images and cure of advanced cancer patients. Cancer-affine formulations of Tc-99m(V), Re-186(V) and Re-188(V)-DMSA are being studied for their future use in early diagnosis and follow-up, and for the systemic therapy of cancer which will show affinity for them. (author)

  15. A microcomputer controlled snow ski binding system--II. Release decision theories.

    Science.gov (United States)

    MacGregor, D; Hull, M L

    1985-01-01

    A hierarchy of release decision theories for both tibia fracture and knee ligamentous injury are defined and simulated on a computer. Moment loading data, recorded during actual skiing by the microcomputer-based ski binding system described in Part I, are processed by the various release decision theories. At the bottom of the hierarchy is the simplest theory which treats boot loading as quasi-static and compares moment components to threshold levels. Another stage of the hierarchy defines an analytic expression for a combined loading failure locus. Note that this is the first formulation of a combined loading release decision theory. Yet another stage of the hierarchy computes bone moments via dynamic system leg models. The various release decision theories are evaluated by comparing processed results to both pain and bone failure limits. For the data generated by the field tests conducted to date, the simplest release decision theory satisfied the retention requirement for pain limits in the presence of muscle activity for both torsion and forward bending. For pain limits in the absence of muscle activity the retention requirement was not satisfied however. Another result is that leg dynamics are significant. A final result is that combined loading considerations lead to a more conservative theory.

  16. Automating the First-Order Theory of Rewriting for Left-Linear Right-Ground Rewrite Systems

    OpenAIRE

    Rapp, Franziska; Middeldorp, Aart

    2016-01-01

    The first-order theory of rewriting is decidable for finite left-linear right-ground rewrite systems. We present a new tool that implements the decision procedure for this theory. It is based on tree automata techniques. The tool offers the possibility to synthesize rewrite systems that satisfy properties that are expressible in the first-order theory of rewriting.

  17. Foundations of Feedback Theory for Nonlinear Dynamical Systems

    Science.gov (United States)

    1979-08-31

    particular, if for T EV sufficiently large, ([ FCK ) -1 ] << 1 (11.10) and I F- 1 r(0T I(FGK)- rT << -- , Vr ,1.d T 1(F-) d,e then asymptotically, ! l~-yr...evaluated at (I+FGK) (r+0ar) with Ar = F[G(u+d )-C(u)], u := K([+ FCK )-1 r, and a G [0,1. ~, g . Proof of Proposition 111.6: see Appendix. Proosition...plant G with u - 1.2sInt and the closed- loop system GK(I+ FCK ) with r = 0.92 sinwt. The corresponding (open-loop system) output yo and the (cl.osed

  18. Interacting systems far from equilibrium quantum kinetic theory

    CERN Document Server

    Morawetz, Klaus

    2018-01-01

    This book presents an up-to-date formalism of non-equilibrium Green's functions covering different applications ranging from solid state physics, plasma physics, cold atoms in optical lattices up to relativistic transport and heavy ion collisions. Within the Green's function formalism, the basic sets of equations for these diverse systems are similar, and approximations developed in one field can be adapted to another field. The central object is the self-energy which includes all non-trivial aspects of the system dynamics. The focus is therefore on microscopic processes starting from elementary principles for classical gases and the complementary picture of a single quantum particle in a random potential. This provides an intuitive picture of the interaction of a particle with the medium formed by other particles, on which the Green's function is built on.

  19. Kinetic theory of a longitudinally expanding system of scalar particles

    International Nuclear Information System (INIS)

    Epelbaum, Thomas; Gelis, François; Jeon, Sangyong; Moore, Guy; Wu, Bin

    2015-01-01

    A simple kinematical argument suggests that the classical approximation may be inadequate to describe the evolution of a system with an anisotropic particle distribution. In order to verify this quantitatively, we study the Boltzmann equation for a longitudinally expanding system of scalar particles interacting with a ϕ 4 coupling, that mimics the kinematics of a heavy ion collision at very high energy. We consider only elastic 2→2 scatterings, and we allow the formation of a Bose-Einstein condensate in overpopulated situations by solving the coupled equations for the particle distribution and the particle density in the zero mode. For generic CGC-like initial conditions with a large occupation number, the solutions of the full Boltzmann equation cease to display the classical attractor behavior sooner than expected; for moderate coupling, the solutions appear never to follow a classical attractor solution.

  20. General laser interaction theory in atom-diatom systems for both adiabatic and nonadiabatic cases.

    Science.gov (United States)

    Li, Xuan; Brue, Daniel A; Parker, Gregory A; Chang, Sin-Tarng

    2006-04-27

    This paper develops the general theory for laser fields interacting with bimolecular systems. In this study, we choose to use the multipolar gauge on the basis of gauge invariance. We consider both the adiabatic and nonadiabatic cases and find they produce similar interaction pictures. As an application of this theory, we present the study of rovibrational energy transfer in Ar + CO collisions in the presence of an intense laser field.