WorldWideScience

Sample records for binding-mechanism concerned models

  1. DNA-binding residues and binding mode prediction with binding-mechanism concerned models

    OpenAIRE

    Oyang Yen-Jen; Liu Yu-Cheng; Huang Chun-Chin; Huang Yu-Feng; Huang Chien-Kang

    2009-01-01

    Abstract Background Protein-DNA interactions are essential for fundamental biological activities including DNA transcription, replication, packaging, repair and rearrangement. Proteins interacting with DNA can be classified into two categories of binding mechanisms - sequence-specific and non-specific binding. Protein-DNA specific binding provides a mechanism to recognize correct nucleotide base pairs for sequence-specific identification. Protein-DNA non-specific binding shows sequence indepe...

  2. Spectroscopic and molecular modelling studies of binding mechanism of metformin with bovine serum albumin

    Science.gov (United States)

    Sharma, Deepti; Ojha, Himanshu; Pathak, Mallika; Singh, Bhawna; Sharma, Navneet; Singh, Anju; Kakkar, Rita; Sharma, Rakesh K.

    2016-08-01

    Metformin is a biguanide class of drug used for the treatment of diabetes mellitus. It is well known that serum protein-ligand binding interaction significantly influence the biodistribution of a drug. Current study was performed to characterize the binding mechanism of metformin with serum albumin. The binding interaction of the metformin with bovine serum albumin (BSA) was examined using UV-Vis absorption spectroscopy, fluorescence, circular dichroism, density functional theory and molecular docking studies. Absorption spectra and fluorescence emission spectra pointed out the weak binding of metformin with BSA as was apparent from the slight change in absorbance and fluorescence intensity of BSA in presence of metformin. Circular dichroism study implied the significant change in the conformation of BSA upon binding with metformin. Density functional theory calculations showed that metformin has non-planar geometry and has two energy states. The docking studies evidently signified that metformin could bind significantly to the three binding sites in BSA via hydrophobic, hydrogen bonding and electrostatic interactions. The data suggested the existence of non-covalent specific binding interaction in the complexation of metformin with BSA. The present study will certainly contribute to the development of metformin as a therapeutic molecule.

  3. Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model

    Energy Technology Data Exchange (ETDEWEB)

    Knott, Michael [Department of Chemistry, Cambridge University, Lensfield Road, Cambridge CB2 1EW (United Kingdom); Best, Robert B., E-mail: robertbe@helix.nih.gov [Department of Chemistry, Cambridge University, Lensfield Road, Cambridge CB2 1EW (United Kingdom); Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520 (United States)

    2014-05-07

    Many proteins undergo a conformational transition upon binding to their cognate binding partner, with intrinsically disordered proteins (IDPs) providing an extreme example in which a folding transition occurs. However, it is often not clear whether this occurs via an “induced fit” or “conformational selection” mechanism, or via some intermediate scenario. In the first case, transient encounters with the binding partner favour transitions to the bound structure before the two proteins dissociate, while in the second the bound structure must be selected from a subset of unbound structures which are in the correct state for binding, because transient encounters of the incorrect conformation with the binding partner are most likely to result in dissociation. A particularly interesting situation involves those intrinsically disordered proteins which can bind to different binding partners in different conformations. We have devised a multi-state coarse-grained simulation model which is able to capture the binding of IDPs in alternate conformations, and by applying it to the binding of nuclear coactivator binding domain (NCBD) to either ACTR or IRF-3 we are able to determine the binding mechanism. By all measures, the binding of NCBD to either binding partner appears to occur via an induced fit mechanism. Nonetheless, we also show how a scenario closer to conformational selection could arise by choosing an alternative non-binding structure for NCBD.

  4. Integration of in vitro binding mechanism into the semiphysiologically based pharmacokinetic interaction model between ketoconazole and midazolam.

    Science.gov (United States)

    Quinney, Sara K; Knopp, Shawn; Chang, Chien; Hall, Stephen D; Li, Lang

    2013-01-01

    In vitro screening for drug-drug interactions is an integral component of drug development, with larger emphasis now placed on the use of in vitro parameters to predict clinical inhibition. However, large variability exists in Ki reported for ketoconazole with midazolam, a model inhibitor-substrate pair for CYP3A. We reviewed the literature and extracted Ki for ketoconazole as measured by the inhibition of hydroxymidazolam formation in human liver microsomes. The superset of data collected was analyzed for the impact of microsomal binding, using Langmuir and phase equilibrium binding models, and fitted to various inhibition models: competitive, noncompetitive, and mixed. A mixed inhibition model with binding corrected by an independent binding model was best able to fit the data (Kic = 19.2 nmol/l and Kin = 39.8 nmol/l) and to predict clinical effect of ketoconazole on midazolam area under the concentration-time curve. The variability of reported Ki may partially be explained by microsomal binding and choice of inhibition model. PMID:24448021

  5. Integration of In Vitro Binding Mechanism Into the Semiphysiologically Based Pharmacokinetic Interaction Model Between Ketoconazole and Midazolam

    OpenAIRE

    Quinney, Sara K.; Knopp, Shawn; Chang, Chien; Hall, Stephen D.; Li, Lang

    2013-01-01

    In vitro screening for drug–drug interactions is an integral component of drug development, with larger emphasis now placed on the use of in vitro parameters to predict clinical inhibition. However, large variability exists in K i reported for ketoconazole with midazolam, a model inhibitor–substrate pair for CYP3A. We reviewed the literature and extracted K i for ketoconazole as measured by the inhibition of hydroxymidazolam formation in human liver microsomes. The superset of data collected ...

  6. Binding mechanism of the tyrosine-kinase inhibitor nilotinib to human serum albumin determined by (1)H STD NMR, (19)F NMR, and molecular modeling.

    Science.gov (United States)

    Yan, Jin; Wu, Di; Sun, Pingchuan; Ma, Xiaoli; Wang, Lili; Li, Shanshan; Xu, Kailin; Li, Hui

    2016-05-30

    Drug interaction with albumins significantly affects in vivo drug transport and biological metabolism. To gain insight into the binding mechanisms of tyrosine-kinase inhibitor nilotinib (NIL) to human serum albumin (HSA), an approach combining (1)H saturation-transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy, (19)F NMR spectroscopy, steady-state fluorescence quenching, and molecular modeling was adopted. (19)F NMR was used to determine the binding constant, and a value of 4.12×10(3)M(-1) was obtained. Fluorescence spectroscopy was also used to determine the binding constant, and the value obtained was within the same order of magnitude. The binding process was mainly driven by hydrogen bonds and van der Waals forces. Displacement experiments further showed that NIL mainly bound to the hydrophobic cavity of HSA's subdomain IIA, also called Sudlow's site I. Molecular docking simulation was also used to establish a molecular binding model, and findings were consistent with those of displacement and the (1)H STD NMR experiments. PMID:26922576

  7. Plato's Protagoras: Professional Models, Ethical Concerns.

    Science.gov (United States)

    Gregory, Marshall W.

    1983-01-01

    In Plato's model his clear criticism of Protagorean careerism and his negotiation with Socratic radicalism shows he is a centrist cultivating criticism and open discourse. In an age when academe seems to have lost a sense of its identify and function in society, its most enduring contributions are criticism and discourse. (MLW)

  8. Fairness concerns in digital right management models

    OpenAIRE

    Bouganim, Luc; Pucheral, Philippe

    2007-01-01

    Digital piracy is threatening the global multimedia content industry and blindly applied coercive Digital Right Management (DRM) policies do nothing but legitimise this piracy. This paper presents new software and hardware infrastructure aimed at reconciling the content providers' and consumers' points of view by giving the ability to develop fair business models (i.e., that preserve the interest of both parties). The solution is based on the use of tamper-resistant devices (smart cards) to s...

  9. Model conception concerning rewetting by flooding

    International Nuclear Information System (INIS)

    Thermohydraulics essentially influences the wetting temperature, which may be assumed for the flooding phase to be a function of pressure and subcooling of the fluid. A one-dimensional heat transfer model was shown to describe the phenomena in the pipe wall to be wetted in a sufficiently correct manner, if the dependence on fluid subcooling is considered for the wetting temperature. The influence of the parameters mass flow, subcooling of the flooding water, system pressure, heat production, channel cross-section, and steam content near the wetting front on the speed of the wetting front were shown. (GL)

  10. Supporting crosscutting concern modelling in software architecture design

    Institute of Scientific and Technical Information of China (English)

    CAO Donggang; MEI Hong; ZHOU Minghui

    2007-01-01

    Crosscutting concerns such as logging,security,and transaction,are well supported in the programming level by aspect-oriented programming technologies.However,addressing these issues in the high-level architecture design still remains open.This paper presents a novel approach to supporting crosscutting concern modelling in the software architecture design of component-based systems.We introduce a new element named "Aspect"into our architecture description language,ABC/ADL,to clearly model the behavior of crosscutting concerns.Aspect is the first class entity as Component and Connector in ABC/ADL.ABC/ADL Connectors provide the weaving points where the component and aspect crosscut.This approach effectively enables "separation of concerns" in high-level architecture design,and facilitates black-box reuse of COTS components.

  11. The Statistical Modeling of the Trends Concerning the Romanian Population

    Directory of Open Access Journals (Sweden)

    Gabriela OPAIT

    2014-11-01

    Full Text Available This paper reflects the statistical modeling concerning the resident population in Romania, respectively the total of the romanian population, through by means of the „Least Squares Method”. Any country it develops by increasing of the population, respectively of the workforce, which is a factor of influence for the growth of the Gross Domestic Product (G.D.P.. The „Least Squares Method” represents a statistical technique for to determine the trend line of the best fit concerning a model.

  12. Binding Mechanisms in Selective Laser Sintering and Selective Laser Melting

    NARCIS (Netherlands)

    Kruth, J.-P.; Mercelis, P.; Van Vaerenbergh, J.; Froyen, L.; Rombouts, M.

    2005-01-01

    Purpose – This paper provides an overview of the different binding mechanisms in selective laser sintering (SLS) and selective laser melting (SLM), thus improving the understanding of these processes. Design/methodology/approach – A classification of SLS/SLM processes was developed, based on the bin

  13. Defining Scenarios: Linking Integrated Models, Regional Concerns, and Stakeholders

    Science.gov (United States)

    Hartmann, H. C.; Stewart, S.; Liu, Y.; Mahmoud, M.

    2007-05-01

    Scenarios are important tools for long-term planning, and there is great interest in using integrated models in scenario studies. However, scenario definition and assessment are creative, as well as scientific, efforts. Using facilitated creative processes, we have worked with stakeholders to define regionally significant scenarios that encompass a broad range of hydroclimatic, socioeconomic, and institutional dimensions. The regional scenarios subsequently inform the definition of local scenarios that work with context-specific integrated models that, individually, can address only a subset of overall regional complexity. Based on concerns of stakeholders in the semi-arid US Southwest, we prioritized three dimensions that are especially important, yet highly uncertain, for long-term planning: hydroclimatic conditions (increased variability, persistent drought), development patterns (urban consolidation, distributed rural development), and the nature of public institutions (stressed, proactive). Linking across real-world decision contexts and integrated modeling efforts poses challenges of creatively connecting the conceptual models held by both the research and stakeholder communities.

  14. A mineralogical study of the binding mechanisms in chromite briquettes

    International Nuclear Information System (INIS)

    Briquettes are made of chromite fines and a suitable binding material which are fed into a pillow-shaped mould, and pressure is applied to compact the material. The Council for Mineral Technology and Middelburg Steel and Alloys have taken out a provisional patent for the manufacturing of composite briquettes containing not only reducing agents but also fluxes, which will improve the efficiency of the reduction process. Briquettes were examined and the results were correlated with the strengths of the briquettes, which were measured in drop tests, compressive strength and abrasive resistance. The mineralogical procedures included differential thermal analysis, x-ray diffraction, infrared spectroscopy, scanning electron microscope, energy-dispersive spectroscopy and the use of the electron microprobe. The information obtained by these procedures enabled the determination of the nature of the binding mechanisms. Six different types of briquettes, with their respective binding mechanisms were studied

  15. Concerning the Feasibility of Example-driven Modelling Techniques

    CERN Document Server

    Thorne, Simon R; Lawson, Z

    2008-01-01

    We report on a series of experiments concerning the feasibility of example driven modelling. The main aim was to establish experimentally within an academic environment: the relationship between error and task complexity using a) Traditional spreadsheet modelling; b) example driven techniques. We report on the experimental design, sampling, research methods and the tasks set for both control and treatment groups. Analysis of the completed tasks allows comparison of several different variables. The experimental results compare the performance indicators for the treatment and control groups by comparing accuracy, experience, training, confidence measures, perceived difficulty and perceived completeness. The various results are thoroughly tested for statistical significance using: the Chi squared test, Fisher's exact test for significance, Cochran's Q test and McNemar's test on difficulty.

  16. Modelling information dissemination under privacy concerns in social media

    Science.gov (United States)

    Zhu, Hui; Huang, Cheng; Lu, Rongxing; Li, Hui

    2016-05-01

    Social media has recently become an important platform for users to share news, express views, and post messages. However, due to user privacy preservation in social media, many privacy setting tools are employed, which inevitably change the patterns and dynamics of information dissemination. In this study, a general stochastic model using dynamic evolution equations was introduced to illustrate how privacy concerns impact the process of information dissemination. Extensive simulations and analyzes involving the privacy settings of general users, privileged users, and pure observers were conducted on real-world networks, and the results demonstrated that user privacy settings affect information differently. Finally, we also studied the process of information diffusion analytically and numerically with different privacy settings using two classic networks.

  17. Composing Software from Multiple Concerns: A Model and Composition Anomalies

    NARCIS (Netherlands)

    Bergmans, Lodewijk M.J.; Aksit, Mehmet

    2000-01-01

    Constructing software from components is considered to be a key requirement for managing the complexity of software. Separation of concerns makes only sense if the realizations of these concerns can be composed together effectively into a working program. Various publications have shown that composa

  18. A sequential binding mechanism in a PDZ domain

    DEFF Research Database (Denmark)

    Chi, Celestine N; Bach, Anders; Engström, Åke; Wang, Huiqun; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per

    2009-01-01

    Conformational selection and induced fit are two well-known mechanisms of allosteric protein-ligand interaction. Some proteins, like ubiquitin, have recently been found to exist in multiple conformations at equilibrium, suggesting that the conformational selection may be a general mechanism of...... interaction, in particular for single-domain proteins. Here, we found that the PDZ2 domain of SAP97 binds its ligand via a sequential (induced fit) mechanism. We performed binding experiments using SAP97 PDZ2 and peptide ligands and observed biphasic kinetics with the stopped-flow technique, indicating that...... ligand binding involves at least a two-step process. By using an ultrarapid continuous-flow mixer, we then detected a hyperbolic dependence of binding rate constants on peptide concentration, corroborating the two-step binding mechanism. Furthermore, we found a similar dependence of the rate constants on...

  19. Online Grocery Shopping: Consumer Motives, Concerns, and Business Models

    OpenAIRE

    Kempiak, Mike; Fox, Mark

    2002-01-01

    Dot.com entrepreneurs failed spectacularly in their attempts to create e-grocery companies. This paper examines consumer motives and concerns with regard to online grocery shopping. The reasons for the success experienced by traditional bricks-and-mortar companies that have expanded into this market are also examined.

  20. An Examination of Interactive Whiteboard Perceptions using the Concerns-Based Adoption Model Stages of Concern and the Apple Classrooms of Tomorrow Model of Instructional Evolution

    Science.gov (United States)

    Hall, Jeffrey; Chamblee, Gregory; Slough, Scott

    2013-01-01

    Two high school mathematics teachers who use Interactive Whiteboards (IWBs) in the classroom were interviewed annually over the course of three years regarding their perceptions of the technology. During the third year, the two teachers were asked to complete the Concerns-Based Adoption Model Stages of Concern Questionnaire. The data obtained from…

  1. Applications of covariance structure modeling in psychology: cause for concern?

    Science.gov (United States)

    Breckler, S J

    1990-03-01

    Methods of covariance structure modeling are frequently applied in psychological research. These methods merge the logic of confirmatory factor analysis, multiple regression, and path analysis within a single data analytic framework. Among the many applications are estimation of disattenuated correlation and regression coefficients, evaluation of multitrait-multimethod matrices, and assessment of hypothesized causal structures. Shortcomings of these methods are commonly acknowledged in the mathematical literature and in textbooks. Nevertheless, serious flaws remain in many published applications. For example, it is rarely noted that the fit of a favored model is identical for a potentially large number of equivalent models. A review of the personality and social psychology literature illustrates the nature of this and other problems in reported applications of covariance structure models. PMID:2320704

  2. Modelling and analysis of multiagent systems concerning cooperation problems

    OpenAIRE

    Reinhold, Thomas

    2005-01-01

    The subject of this diploma thesis is the modelling and the analysis of mechanisms that enable multiagentsystems to establish communication relations and using them to control the interaction. With regards to the emergence of such symbol systems one groundwork of this paper is the realization that coordination problems aren't applicative to advance to evolution of "higher communication capabilities". With this in mind, this analysis uses a class of problems with explicit conflicts of inte...

  3. A model problem concerning ionic transport in microstructured solid electrolytes

    Science.gov (United States)

    Curto Sillamoni, Ignacio J.; Idiart, Martín I.

    2015-11-01

    We consider ionic transport by diffusion and migration through microstructured solid electrolytes. The assumed constitutive relations for the constituent phases follow from convex energy and dissipation potentials which guarantee thermodynamic consistency. The effective response is determined by homogenizing the relevant field equations via the notion ofmulti-scale convergence. The resulting homogenized response involves several effective tensors, but they all require the solution of just one standard conductivity problem over the representative volume element. A multi-scale model for semicrystalline polymer electrolytes with spherulitic morphologies is derived by applying the theory to a specific class of two-dimensional microgeometries for which the effective response can be computed exactly. An enriched model accounting for a random dispersion of filler particles with interphases is also derived. In both cases, explicit expressions for the effective material parameters are provided. The models are used to explore the effect of crystallinity and filler content on the overall response. Predictions support recent experimental observations on doped poly-ethylene-oxide systems which suggest that the anisotropic crystalline phase can actually support faster ion transport than the amorphous phase along certain directions dictated by the morphology of the polymeric chains. Predictions also support the viewpoint that ceramic fillers improve ionic conductivity and cation transport number via interphasial effects.

  4. An illustration of the Arena model: Conflicts concerning nuclear energy

    International Nuclear Information System (INIS)

    The author examines the current relevance of the debate on risk and presents a systematic survey of theoretical concepts of risk: Technical foundations, economic and psychological perspectives, sociological and cultural-anthropological perspectives as well as social mobilization and the arena model, arenas for settling conflicts being parliament, administrative institutions, the legal realm, the humanities and sciences, mass media etc. The arena model is illustrated using atomic energy as an example, whereby the following factors are taken into account: The political arena, the function of the normal authority, agents, the media as a medium for action and public opinion. Conclusion: Three elements are necessary for a rational and democratic policy for dealing with risks: Experts on the theoretical aspects of the issue must be consulted, the legitimate interests of those persons in the arena who are affected by the decision must be taken into acoount and a representative public opinion poll which determines whether the public is in favour of possible political options must be carried out, thus giving them the opportunity to participate in the decision-making procedure. The better a process is prestructured before such a participatory procedure is initiated, the more likely it is that acceptance and acceptability can be obtained. (orig./HSCH)

  5. Binding models concerning natural organic substances in performance assessment

    International Nuclear Information System (INIS)

    Natural organic substances (i.e., humic and fulvic acids) are important in radioactive waste disposal programmes for predicting the fate of radionuclides migration in the environment. A recent workshop organised by the OECD Nuclear Energy Agency, in co-operation with the Paul Scherrer Institute (Switzerland), brought together experts from various Nea Member countries to discuss and review the current evaluation of natural organic substances, their characterisation and isolation, documentation on existing mathematical models, competition with inorganic ligands in forming radionuclide complexes, and their influence in performance assessment for a variety of geologic media. These proceedings present the papers submitted at the workshop and a summary of the discussions on the role of organic substances in performance assessment. (authors). 432 refs., 119 figs., 53 tabs

  6. Models of Students' Thinking Concerning the Greenhouse Effect and Teaching Implications.

    Science.gov (United States)

    Koulaidis, Vasilis; Christidou, Vasilia

    1999-01-01

    Primary school students (n=40) ages 11 and 12 years were interviewed concerning their conceptions of the greenhouse effect. Analysis of the data led to the formation of seven distinct models of thinking regarding this phenomenon. (Author/CCM)

  7. Results of a modeling workshop concerning development of the Beluga coal resource in Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of a modeling workshop concerning development of the Beluga coal resource in Alaska. The workshop was facilitated by the AEA...

  8. Recommendations concerning models and parameters best suited to breeder reactor environmental radiological assessments

    International Nuclear Information System (INIS)

    Recommendations are presented concerning the models and parameters best suited for assessing the impact of radionuclide releases to the environment by breeder reactor facilities. These recommendations are based on the model and parameter evaluations performed during this project to date. Seven different areas are covered in separate sections

  9. Recommendations concerning models and parameters best suited to breeder reactor environmental radiological assessments

    Energy Technology Data Exchange (ETDEWEB)

    Miller, C.W.; Baes, C.F. III; Dunning, D.E. Jr.

    1980-05-01

    Recommendations are presented concerning the models and parameters best suited for assessing the impact of radionuclide releases to the environment by breeder reactor facilities. These recommendations are based on the model and parameter evaluations performed during this project to date. Seven different areas are covered in separate sections.

  10. Computational Study of the Binding Mechanism of Actin-Depolymerizing Factor 1 with Actin in Arabidopsis thaliana.

    Science.gov (United States)

    Du, Juan; Wang, Xue; Dong, Chun-Hai; Yang, Jian Ming; Yao, Xiao Jun

    2016-01-01

    Actin is a highly conserved protein. It plays important roles in cellular function and exists either in the monomeric (G-actin) or polymeric form (F-actin). Members of the actin-depolymerizing factor (ADF)/cofilin protein family bind to both G-actin and F-actin and play vital roles in actin dynamics by manipulating the rates of filament polymerization and depolymerization. It has been reported that the S6D and R98A/K100A mutants of actin-depolymerizing factor 1 (ADF1) in Arabidopsis thaliana decreased the binding affinity of ADF for the actin monomer. To investigate the binding mechanism and dynamic behavior of the ADF1-actin complex, we constructed a homology model of the AtADF1-actin complex based on the crystal structure of AtADF1 and the twinfilin C-terminal ADF-H domain in a complex with a mouse actin monomer. The model was then refined for subsequent molecular dynamics simulations. Increased binding energy of the mutated system was observed using the Molecular Mechanics Generalized Born Surface Area and Poisson-Boltzmann Surface Area (MM-GB/PBSA) methods. To determine the residues that make decisive contributions to the ADF1 actin-binding affinity, per-residue decomposition and computational alanine scanning analyses were performed, which provided more detailed information on the binding mechanism. Root-mean-square fluctuation and principal component analyses confirmed that the S6D and R98A/K100A mutants induced an increased conformational flexibility. The comprehensive molecular insight gained from this study is of great importance for understanding the binding mechanism of ADF1 and G-actin. PMID:27414648

  11. The binding mechanism of a peptidic cyclic serine protease inhibitor

    DEFF Research Database (Denmark)

    Jiang, Longguang; Svane, Anna S P; Sørensen, Hans Peter; Jensen, Jan K; Hosseini, Masood; Chen, Zhuo; Weydert, Caroline; Nielsen, Jakob T; Christensen, Anni; Yuan, Cai; Jensen, Knud Jørgen; Nielsen, Niels Chr; Malmendal, Anders; Huang, Mingdong; Andreasen, Peter

    2011-01-01

    Serine proteases are classical objects for studies of catalytic and inhibitory mechanisms as well as interesting as therapeutic targets. Since small-molecule serine protease inhibitors generally suffer from specificity problems, peptidic inhibitors, isolated from phage-displayed peptide libraries......, have attracted considerable attention. Here, we have investigated the mechanism of binding of peptidic inhibitors to serine protease targets. Our model is upain-1 (CSWRGLENHRMC), a disulfide-bond-constrained competitive inhibitor of human urokinase-type plasminogen activator with a noncanonical...... inhibitory mechanism and an unusually high specificity. Using a number of modified variants of upain-1, we characterised the upain-1-urokinase-type plasminogen activator complex using X-ray crystal structure analysis, determined a model of the peptide in solution by NMR spectroscopy, and analysed binding...

  12. Impact of Evolution of Concerns in the Model-Driven Architecture Design Approach

    NARCIS (Netherlands)

    Tekinerdogan, Bedir; Aksit, Mehmet; Henninger, Francis

    2007-01-01

    Separation of concerns is an important principle for designing high quality software systems and is both applied in the Model-Driven Architecture (MDA) and Aspect-Oriented Software Development (AOSD). The AOSD and MDA techniques seem to be complementary to each other; historically AOSD has focused o

  13. Consideration of a Model: Toward Possible Resolution of Some Professional Concerns.

    Science.gov (United States)

    Brumbaugh, Robert B.

    This paper describes and illustrates the use of a recently developed management simulation-information model, suggesting it as one possible step toward partial solution of two longstanding concerns in educational administration. These problems are (1) the myopic and parochial "problems" view of education and (2) the schism between professor and…

  14. Exploring the binding mechanisms of MIF to CXCR2 using theoretical approaches.

    Science.gov (United States)

    Xu, Lei; Li, Youyong; Li, Dan; Xu, Peng; Tian, Sheng; Sun, Huiyong; Liu, Hui; Hou, Tingjun

    2015-02-01

    Macrophage migration inhibitory factor (MIF) is a multi-functional protein that acts as a cytokine and as an enzyme. Recently, MIF was identified as a non-canonical ligand of G protein-coupled chemokine receptor CXCR2 with low nanomolar affinity in leukocyte arrest and chemotaxis, but the precise knowledge of the molecular determinants of the MIF-CXCR2 interface has remained unknown. Therefore, we employed homology modeling, protein-protein docking, molecular dynamics (MD) simulations, Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) binding free energy calculations and MM/GBSA binding free energy decomposition to obtain insights into the molecular recognition of MIF with CXCR2. The predicted binding pattern of MIF-CXCR2 is in good agreement with the experimental data and sheds light on the functional role of important MIF-CXCR2 interface residues in association with binding and signaling. According to our predictions, the R11A/D44A double mutations of MIF exhibit a pronounced defect in the binding affinity of MIF to CXCR2, resulting in large conformational changes. The potential two-site binding model for the MIF-CXCR2 recognition was proposed: initialized primarily by the non-polar interactions including the van der Waals and hydrophobic interactions, the N-terminal region of CXCR2 contacts the N-like loop and β-sheet of MIF (site 1), and then the ECL2 and ECL3 regions of CXCR2 form strong interactions with the pseudo-(E)LR motif and C-terminus of MIF, which induces the molecular thermodynamic motion of TMs for signal transduction (site 2). This study will extend our understanding to the binding mechanisms of MIF to CXCR2 and provide useful information for the rational design of potent inhibitors selectively targeting the MIF-CXCR2 interactions. PMID:25526079

  15. Improving the reliability modeling concerning the emergency core cooling system at Gentilly-2 Nuclear Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Komljenovic, D.; Vaillancourt, R.; Croteau, M. [Hydro Quebec, Gentilly-2, Nuclear Generating Station, Quebec (Canada); Abdul-Nour, G.; Darragi, M. [Univ. du Quebec a Trois Rivieres, Trois Rivieres, Quebec (Canada)

    2003-07-01

    This technical paper presents an approach to improving the reliability modeling concerning the performance of the Emergency Core Cooling (ECC) System at Gentilly-2 Nuclear Generating Station following a loss of coolant accident (LOCA). It includes a quantitative unavailability analysis based on the current system design and operation. The study is performed as a part of a project with regard to an extension of the plant planned outage period. (author)

  16. Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

    Directory of Open Access Journals (Sweden)

    Yan Li

    2015-04-01

    Full Text Available Cyclin-dependent kinase 2 (CDK2 is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, these activation steps bring some dynamic changes on the 3D-structure of the kinase, especially the activation segment. Until now, in the monomeric CDK2 structure, three binding sites have been reported, including the adenosine triphosphate (ATP binding site (Site I and two non-competitive binding sites (Site II and III. In addition, when the kinase is subjected to the cyclin binding process, the resulting structural changes give rise to a variation of the ATP binding site, thus generating an allosteric binding site (Site IV. All the four sites are demonstrated as being targeted by corresponding inhibitors, as is illustrated by the allosteric binding one which is targeted by inhibitor ANS (fluorophore 8-anilino-1-naphthalene sulfonate. In the present work, the binding mechanisms and their fluctuations during the activation process attract our attention. Therefore, we carry out corresponding studies on the structural characterization of CDK2, which are expected to facilitate the understanding of the molecular mechanisms of kinase proteins. Besides, the binding mechanisms of CDK2 with its relevant inhibitors, as well as the changes of binding mechanisms following conformational variations of CDK2, are summarized and compared. The summary of the conformational characteristics and ligand binding mechanisms of CDK2 in the present work will improve our understanding of the molecular mechanisms regulating the bioactivities of CDK2.

  17. A Study on Efficient Mobile IPv6 Fast Handover Scheme Using Reverse Binding Mechanism

    Science.gov (United States)

    Tolentino, Randy S.; Lee, Kijeong; Kim, Sung-Gyu; Kim, Miso; Park, Byungjoo

    This paper proposes a solution for solving the packet handover issues of MIPv6. We propose an efficient scheme that can support fast handover effectively in standard Mobile IPv6 (MIPv6) by optimizing the associated data and the flow of signal during handover. A new signaling message Reverse Packet Binding Mechanism is defined and utilized to hasten the handover procedure by adding a buffer in access point (AP) and home agent (HA).

  18. Sensitivity analysis of a forest gap model concerning current and future climate variability

    Energy Technology Data Exchange (ETDEWEB)

    Lasch, P.; Suckow, F.; Buerger, G.; Lindner, M.

    1998-07-01

    The ability of a forest gap model to simulate the effects of climate variability and extreme events depends on the temporal resolution of the weather data that are used and the internal processing of these data for growth, regeneration and mortality. The climatological driving forces of most current gap models are based on monthly means of weather data and their standard deviations, and long-term monthly means are used for calculating yearly aggregated response functions for ecological processes. In this study, the results of sensitivity analyses using the forest gap model FORSKA{sub -}P and involving climate data of different resolutions, from long-term monthly means to daily time series, including extreme events, are presented for the current climate and for a climate change scenario. The model was applied at two sites with differing soil conditions in the federal state of Brandenburg, Germany. The sensitivity of the model concerning climate variations and different climate input resolutions is analysed and evaluated. The climate variability used for the model investigations affected the behaviour of the model substantially. (orig.)

  19. Recommendations for SZ/TSPA Model Uncertainty Analysis Concerning the Yucca Mountain Project

    Energy Technology Data Exchange (ETDEWEB)

    Bogen, K T

    2003-11-05

    This report considers the problem of how best to evaluate the stability (i.e., sampling reliability) of Monte Carlo outputs obtained for two Yucca Mountain Project (YMP) modeling components, namely, outputs for the Saturated Zone (SZ) model, and for the Total System Performance Assessment (TSPA) model. One approach considered is the one that has been employed to date, namely, the application of Monte Carlo methods. Also considered in this context are potential improvements that might be obtained by the additional use of a Monte Carlo ''quitting rule'', such as that defined by Woo (1991), to select the number of Monte Carlo sample runs to perform. By the Monte Carlo approach, each output-value sample (realization) is calculated as a function of a sample-value vector of stochastic realizations, each of which in turn corresponds to a value of a corresponding distributed input variable. Abstractions from the SZ model and the Biosphere model are both used as input to the TSPA model. Sets of stochastic realizations required for SZ and TSPA abstractions ''expensive'' to generate, so the practical issue addressed by a ''quitting rule'' is how to determine what number of realizations is ''enough'' for the purpose of characterizing sampling error in the Monte Carlo estimate obtained for a specified model output of concern. In the TSPA context, the model output of concern is generally considered the time evolution of the arithmetic mean value, an estimator of the expected value, of TSPA-generated annual dose D(t) to the defined receptor within 10,000 y after waste-repository closure. Recommendations below specifically address: (1) whether or not a Monte Carlo approach (such as one employing the Woo quitting rule) is an appropriate basis for undertaking SZ- or TSPA-related uncertainty analysis, and (2) what other method might be more appropriate. While the following discussion and recommendations

  20. Some subtleties concerning fluid flow and turbulence modeling in 4.-valve engines

    Directory of Open Access Journals (Sweden)

    Jovanovic Zoran S.

    2011-01-01

    Full Text Available In this paper some results concerning the structure and evolution of fluid flow pattern during induction and compression in 4.- valve engines with tilted valves were presented. Results were obtained by dint of multidimensional modeling of non-reactive flows in arbitrary geometry with moving boundaries. During induction fluid flow pattern was characterized with organized tumble motion followed by small but clearly legible deterioration in the vicinity of BDC. During compression the fluid flow pattern is entirely three-dimensional and fully controlled by vortex motion located in the central part of the chamber. In order to annihilate negative effects of tumble deterioration and to enhance swirling motion one of the intake valves was deactivated. Some positive and negative effects of such attempt were elucidated. The effect of turbulence model alteration in the case of excessive macro flows was tackled as well. Namely, some results obtained with eddy-viscosity model i.e. standard k-ε model were compared with results obtained with k-ξ-f model of turbulence in domain of 4.-valve engine in-cylinder flow. Some interesting results emerged rendering impetus for further quest in the near future.

  1. Waterfowl populations of conservation concern: learning from diverse challenges, models, and conservation strategies

    Science.gov (United States)

    Austin, Jane E.; Slattery, Stuart; Clark, Robert G.

    2014-01-01

    There are 30 threatened or endangered species of waterfowl worldwide, and several sub-populations are also threatened. Some of these species occur in North America, and others there are also of conservation concern due to declining population trends and their importance to hunters. Here we review conservation initiatives being undertaken for several of these latter species, along with conservation measures in place in Europe, to seek common themes and approaches that could be useful in developing broad conservation guidelines. While focal species may vary in their life histories, population threats and geopolitical context, most conservation efforts have used a systematic approach to understand factors limiting populations and o identify possible management or policy actions. This approach generally includes a priori identification of plausible hypotheses about population declines or status, incorporation of hypotheses into conceptual or quantitative planning models, and the use of some form of structured decision making and adaptive management to develop and implement conservation actions in the face of many uncertainties. A climate of collaboration among jurisdictions sharing these birds is important to the success of a conservation or management programme. The structured conservation approach exemplified herein provides an opportunity to involve stakeholders at all planning stages, allows for all views to be examined and incorporated into model structures, and yields a format for improved communication, cooperation and learning, which may ultimately be one of the greatest benefits of this strategy.

  2. A theory and dynamic model of dyadic interaction : Concerns, appraisals, and contagiousness in a developmental context

    NARCIS (Netherlands)

    Steenbeek, Henderien W.; van Geert, Paul L. C.

    2007-01-01

    A theory of the dynamics of dyadic interaction is presented, based on the concepts of "concern" (i.e., intentions, goals, and interests), "appraisal" and "contagiousness". Differences between children who participate in a specific interaction are linked to differences in social competence and social

  3. Online Grocery Shopping: Consumer Motives, Concerns, and Business Models (originally published in August 2002)

    OpenAIRE

    Kempiak, Mike; Fox, Mark A

    2006-01-01

    Dot.com entrepreneurs failed spectacularly in their attempts to create e-grocery companies. This paper examines consumer motives and concerns with regard to online grocery shopping. The reasons for the success experienced by traditional bricks-and-mortar companies that have expanded into this market are also examined.

  4. The depression distress amplification model in adolescents: A longitudinal examination of anxiety sensitivity cognitive concerns, depression and suicidal ideation.

    Science.gov (United States)

    Capron, Daniel W; Allan, Nicholas P; Ialongo, Nicholas S; Leen-Feldner, Ellen; Schmidt, Norman B

    2015-06-01

    Adolescents with comorbid anxiety and depression are at significantly increased risk of suicide. The recently proposed depression distress amplification model appears to have promise for explaining the relations between anxiety, depression, and suicidality, but it has not been tested in adolescents. Participants were 524 adolescents followed over two years. Baseline data for the current report were collected by trained interviewers while the adolescents were in eighth grade. Data were obtained in the same manner when the adolescents were in tenth grade. Baseline anxiety sensitivity cognitive concerns significantly predicted suicidal ideation two years later, above and beyond baseline suicidal ideation and depression. Further, consistent with the depression distress amplification model, anxiety sensitivity cognitive concerns interacted with depressive symptoms to predict suicidal ideation. This report extends the empirical and theoretical support for a relationship between anxiety sensitivity cognitive concerns and suicidality. PMID:25754194

  5. Structural insights into the substrate-binding mechanism for a novel chitosanase.

    Science.gov (United States)

    Lyu, Qianqian; Wang, Song; Xu, Wenhua; Han, Baoqin; Liu, Wanshun; Jones, David N M; Liu, Weizhi

    2014-07-15

    Chitosanase is able to specifically cleave β-1,4-glycosidic bond linkages in chitosan to produce a chito-oligomer product, which has found a variety of applications in many areas, including functional food and cancer therapy. Although several structures for chitosanase have been determined, the substrate-binding mechanism for this enzyme has not been fully elucidated because of the lack of a high-resolution structure of the chitosanase-substrate complex. In the present study we show the crystal structure of a novel chitosanase OU01 from Microbacterium sp. in complex with its substrate hexa-glucosamine (GlcN)6, which belongs to the GH46 (glycoside hydrolyase 46) family in the Carbohydrate Active Enzymes database (http://www.cazy.org/). This structure allows precise determination of the substrate-binding mechanism for the first time. The chitosanase-(GlcN)6 complex structure demonstrates that, from the -2 to +1 position of the (GlcN)6 substrate, the pyranose rings form extensive interactions with the chitosanase-binding cleft. Several residues (Ser27, Tyr37, Arg45, Thr58, Asp60, His203 and Asp235) in the binding cleft are found to form important interactions required to bind the substrate. Site-directed mutagenesis of these residues showed that mutations of Y37F and H203A abolish catalytic activity. In contrast, the mutations T58A and D235A only lead to a moderate loss of catalytic activity, whereas the S27A mutation retains ~80% of the enzymatic activity. In combination with previous mutagenesis studies, these results suggest that the -2, -1 and +1 subsites play a dominant role in substrate binding and catalysis. DSF (differential scanning fluorimetry) assays confirmed that these mutations had no significant effect on protein stability. Taken together, we present the first mechanistic interpretation for the substrate (GlcN)6 binding to chitosanase, which is critical for the design of novel chitosanase used for biomass conversion. PMID:24766439

  6. A Longitudinal Study of Preservice Music Teacher Development: Application and Advancement of the Fuller and Bown Teacher-Concerns Model

    Science.gov (United States)

    Miksza, Peter; Berg, Margaret H.

    2013-01-01

    The purpose of this study was to investigate the development of preservice music teachers' concerns using Fuller and Bown's model. Participants were 8 instrumental teachers who participated in the previous Berg and Miksza (2010) study. Data sources included goals essays, journals, a midterm growth plan, and teaching observation reports with…

  7. Thinness and Obesity: A Model of Food Consumption, Health Concerns, and Social Pressure

    OpenAIRE

    Dragone, Davide; Savorelli, Luca

    2010-01-01

    The increasing concern of the policy maker about eating behavior has focused on the spread of obesity and on the evidence of a consistent number of individuals dieting despite being underweight. As the latter behavior is often attributed to the social pressure to be thin, some governments have already taken actions to ban ultra-thin ideals and testimonials. Assuming that people are heterogeneous in their healthy weights, but are exposed to the same ideal body weight, this paper proposes a the...

  8. STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism

    Science.gov (United States)

    Létourneau, Danny; Bédard, Mikaël; Cabana, Jérôme; Lefebvre, Andrée; LeHoux, Jean-Guy; Lavigne, Pierre

    2016-01-01

    START domain proteins are conserved α/β helix-grip fold that play a role in the non-vesicular and intracellular transport of lipids and sterols. The mechanism and conformational changes permitting the entry of the ligand into their buried binding sites is not well understood. Moreover, their functions and the identification of cognate ligands is still an active area of research. Here, we report the solution structure of STARD6 and the characterization of its backbone dynamics on multiple time-scales through 15N spin-relaxation and amide exchange studies. We reveal for the first time the presence of concerted fluctuations in the Ω1 loop and the C-terminal helix on the microsecond-millisecond time-scale that allows for the opening of the binding site and ligand entry. We also report that STARD6 binds specifically testosterone. Our work represents a milestone for the study of ligand binding mechanism by other START domains and the elucidation of the biological function of STARD6. PMID:27340016

  9. Hormone- and DNA-binding mechanisms of the recombinant human estrogen receptor.

    Science.gov (United States)

    Obourn, J D; Koszewski, N J; Notides, A C

    1993-06-22

    We have investigated the hormone- and DNA-binding mechanisms of the wild-type human estrogen receptor (hER) overproduced in insect cells using a baculovirus expression system. The recombinant hER was indistinguishable in size (67 kDa) and immunogenically from the native human estrogen receptor in MCF-7 breast carcinoma cells. The recombinant hER was purified to 70-80% homogeneity with a two-step procedure that included ammonium sulfate precipitation and oligonucleotide affinity chromatography using a unique Teflon affinity matrix. The recombinant hER bound estradiol with a positively cooperative mechanism. At hER concentrations in excess of 13 nM the Hill coefficient reached a maximal value of 1.6, whereas, at lower hER concentrations, the Hill coefficient approached 1.0, suggesting that the hER was dissociated to the monomeric species and site-site interactions were diminished. The hER specifically bound an estrogen responsive element (ERE) from chicken vitellogenin II gene as measured by the gel mobility assay, ethylation, and thymine interference footprinting. Specific interference patterns suggest a two-fold symmetry of the hER binding to the ERE with each monomer of the hER bound in the major groove of the DNA. These data indicate that the recombinant hER is valuable to define the biochemical and structural properties of the native estrogen receptor. PMID:8512933

  10. Secure State UML: Modeling and Testing Security Concerns of Software Systems Using UML State Machines

    Directory of Open Access Journals (Sweden)

    S. Batool

    2014-05-01

    Full Text Available In this research we present a technique by using which, extended UML models can be converted to standard UML models so that existing MBT techniques can be applied directly on these models. Existing Model Based Testing (MBT Techniques cannot be directly applied to extended UML models due to the difference of modeling notation and new model elements. Verification of these models is also very important. Realizing and testing non functional requirements such as efficiency, portability and security, at model level strengthens the ability of model to turn down risk, cost and probability of system failure in cost effective way. Access control is most widely used technique for implementing security in software systems. Existing approaches for security modeling focus on representation of access control policies such as authentication, role based access control by introducing security oriented model elements through extension in Unified Modelling Language (UML. But doing so hinders the potential and application of MBT techniques to verify these models and test access control policies. In this research we introduce a technique secure State UML to formally design security models with secure UML and then transform it to UML state machine diagrams so that it can be tested, verified by existing MBT techniques. By applying proposed technique on case studies, we found the results that MBT techniques can be applied on resulting state machine diagrams and generated test paths have potential to identify the risks associated with security constraints violation.

  11. Nonlinear incidence rate of a Pest management SI model with biological and chemical control concern

    Institute of Scientific and Technical Information of China (English)

    JIAO Jian-jun; CHEN Lan-sun

    2007-01-01

    A pest management SI model with impulsive releases of infective pests and spraying pesticides is proposed and investigated. We prove that all solutions of the model are uniformly ultimately bounded. We also obtain the sufficient conditions of globally asymptotic stability periodic solution of pest-extinction and permanence of the model.The approach of combining impulsive releasing infective pests with impulsive spraying pesticides provides reliable tactical basis for the practical pest management.

  12. Outline for an integrated modelling approach concerning risks and economic consequences of contagious animal diseases.

    NARCIS (Netherlands)

    Horst, H.S.; Dijkhuizen, A.A.; Huirne, R.B.M.

    1996-01-01

    Management decisions on control of major infectious animal diseases may have a large impact, but are usually based on scarce and unreliable information. An integrated model which combines the various aspects of outbreaks and risks with economic consequences has yet to be developed. A flexible model

  13. Going Concern eller Concerned Going

    DEFF Research Database (Denmark)

    Haraszuk, Anni; Hartmann, Stig

    2012-01-01

    Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?......Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?...

  14. A model proposal concerning balance scorecard application integrated with resource consumption accounting in enterprise performance management

    Directory of Open Access Journals (Sweden)

    ORHAN ELMACI

    2014-06-01

    Full Text Available The present study intended to investigate the “Balance Scorecard (BSC model integrated with Resource Consumption Accounting (RCA” which helps to evaluate the enterprise as matrix structure in its all parts. It aims to measure how much tangible and intangible values (assets of enterprises contribute to the enterprises. In other words, it measures how effectively, actively, and efficiently these values (assets are used. In short, it aims to measure sustainable competency of enterprises. As expressing the effect of tangible and intangible values (assets of the enterprise on the performance in mathematical and statistical methods is insufficient, it is targeted that RCA Method integrated with BSC model is based on matrix structure and control models. The effects of all complex factors in the enterprise on the performance (productivity and efficiency estimated algorithmically with cause and effect diagram. The contributions of matrix structures for reaching the management functional targets of the enterprises that operate in market competitive environment increasing day to day, is discussed. So in the context of modern management theories, as a contribution to BSC approach which is in the foreground in today’s administrative science of enterprises in matrix organizational structures, multidimensional performance evaluation model -RCA integrated with BSC Model proposal- is presented as strategic planning and strategic evaluation instrument.

  15. Advanced Modeling and Experimental Validation of Complex Nuclear Material Forms of Potential Transportation Concern

    International Nuclear Information System (INIS)

    We present here computer modeling efforts to describe the time-dependent pressurization and gas-phase mole fractions inside sealed canisters containing actinide materials packaged with small (0.12 - 0.5 wt. %) amounts of water. The model is run using Chemkin software, and the chemical reaction mechanism includes gas generation due to radiolysis of adsorbed water, interfacial chemical reactions, and adsorption/desorption kinetics of water on PuO2 materials. The ultimate goal is to provide a verifiable computer model that can be used to predict problematic gas generation in storage forms and assure design criteria for short-term storage and transportation of less than well-characterized (with respect to gas generation) material classes. Our initial efforts are intended to assess pressurization and gas-phase mole fractions using well-defined 3013 container test cases. We have modeled gas generation on PuO2 with water loading up to 0.5 wt. %, at 300 and 525 K, for time frames of 3 years. Estimates of the initial H2 generation rates were determined using RadCalc and employed in the Chemkin model to assess time- and coverage-dependent system behavior. Results indicate that canister pressurization due to radiolysis is a relatively slow process, with pressure increases at 300 K of approximately 1.5 atm. for 5000 g of PuO2 packaged with 0.5 wt. % water. At higher temperatures (> 400 K), desorption of water into the gas phase largely dictates pressurization and the gas-phase mole fractions. These modeling efforts provide a predictive capability for potential gas generation behavior that when augmented and validated by surveillance information will provide a technical basis for safe storage and transportation

  16. Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns

    Science.gov (United States)

    Zhang, Weiwei; Jiao, Bin; Zhou, Miaojin; Zhou, Tao; Shen, Lu

    2016-01-01

    Alzheimer's disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss. While only a few familial AD cases are due to mutations in three causative genes (APP, PSEN1, and PSEN2), the ultimate cause behind the rest of the cases, called sporadic AD, remains unknown. Current animal and cellular models of human AD, which are based on the Aβ and tau hypotheses only, partially resemble the familial AD. As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. Indeed, human induced pluripotent stem cells can be differentiated into disease-relevant cell types that recapitulate the unique genome of a sporadic AD patient or family member. In this review, we will first summarize the current research findings on the genetic and pathological mechanisms of AD. We will then highlight the existing induced pluripotent stem cell models of AD and, lastly, discuss the potential clinical applications in this field. PMID:27313629

  17. Parametric sensitivity of a CFD model concerning the hydrodynamics of trickle-bed reactor (TBR

    Directory of Open Access Journals (Sweden)

    Janecki Daniel

    2016-03-01

    Full Text Available The aim of the present study was to investigate the sensitivity of a multiphase Eulerian CFD model with respect to relations defining drag forces between phases. The mean relative error as well as standard deviation of experimental and computed values of pressure gradient and average liquid holdup were used as validation criteria of the model. Comparative basis for simulations was our own data-base obtained in experiments carried out in a TBR operating at a co-current downward gas and liquid flow. Estimated errors showed that the classical equations of Attou et al. (1999 defining the friction factors Fjk approximate experimental values of hydrodynamic parameters with the best agreement. Taking this into account one can recommend to apply chosen equations in the momentum balances of TBR.

  18. Considerations Concerning Matrix Diagram Transformations Associated with Mathematical Model Study of a Three-phase Transformer

    Directory of Open Access Journals (Sweden)

    Mihaela Poienar

    2014-09-01

    Full Text Available The clock hour figure mathematical model of a threephase transformer can be expressed, in the most plain form, through a 3X3 square matrix, called code matrix. The lines position reflect the modification in the high voltage windings terminal and the columns position reflect the modification in the low voltage winding terminal. The main changes on the transformer winding terminal are: the circular permutation of connection between windings; terminal supply reversal; reverse direction for the phase winding wrapping; reversal the beginning with the end for a phase winding; the connection conversion from N in Z between phase winding or inverse. The analytical form of these changes actually affect the configuration of the mathematical model expressed through a transformations diagram proposed and analyzed in two ways: bipolar version and unipolar version (fanwise. In the end of the paper are presented about the practical exploitation of the transformations diagram.

  19. The Influence of Green Restaurant Decision Formation Using the VAB Model: The Effect of Environmental Concerns upon Intent to Visit

    Directory of Open Access Journals (Sweden)

    Yi-Man Teng

    2014-12-01

    Full Text Available The study investigates consumers’ intent to patron green restaurants by application of the Value-Attitude-Behavior model. The present study examines the interrelationships among consumers’ values, attitudes, and environmental concerns, and explores how they relate to their intentions to visit green restaurants in Taiwan. Data were gathered by face-to-face surveys, conducted by trained interviewers in a variety of locations, including at train stations, supermarkets, department stores, shopping malls, and adult education classes to obtain data from a representative demographic profile. The findings of this study suggest that the personal values and general attitudes positively affect consumers’ intentions to visit a green restaurant. Additionally, the results found personal values and environmental concern have significant influence on the attitude toward green restaurants. Managerial implications and future directions of these findings were also discussed.

  20. A model proposal concerning balance scorecard application integrated with resource consumption accounting in enterprise performance management

    OpenAIRE

    ORHAN ELMACI

    2014-01-01

    The present study intended to investigate the “Balance Scorecard (BSC) model integrated with Resource Consumption Accounting (RCA)” which helps to evaluate the enterprise as matrix structure in its all parts. It aims to measure how much tangible and intangible values (assets) of enterprises contribute to the enterprises. In other words, it measures how effectively, actively, and efficiently these values (assets) are used. In short, it aims to measure sustainable competency of enterprises. ...

  1. Perfectionism, weight and shape concerns, and low self-esteem: Testing a model to predict bulimic symptoms.

    Science.gov (United States)

    La Mela, Carmelo; Maglietta, Marzio; Caini, Saverio; Casu, Giuliano P; Lucarelli, Stefano; Mori, Sara; Ruggiero, Giovanni Maria

    2015-12-01

    Previous studies have tested multivariate models of bulimia pathology development, documenting that a confluence of perfectionism, body dissatisfaction, and low self-esteem is predictive of disordered eating. However, attempts to replicate these results have yielded controversial findings. The objective of the present study was to test an interactive model of perfectionism, weight and shape concerns, and self-esteem in a sample of patients affected by Eating Disorder (ED). One-hundred-sixty-seven ED patients received the Structured Clinical Interview for DSM-IV Axis I (SCID-I), and they completed the Eating Disorder Examination Questionnaire (EDE-Q), the Rosenberg Self-Esteem Scale (RSES), and the Multidimensional Perfectionism Scale (MPS-F). Several mediation analysis models were fit to test whether causal effects of concern over weight and shape on the frequency of bulimic episodes were mediated by perfectionism and moderated by low levels of self-esteem. Contrary to our hypotheses, we found no evidence that the causal relationship investigated was mediated by any of the dimensions of perfectionism. As a secondary finding, the dimensions of perfectionism, perceived criticism and parental expectations, were significantly correlated with the presence of bulimic symptoms. The validity of the interactive model remains controversial, and may be limited by an inadequate conceptualization of the perfectionism construct. PMID:26406884

  2. New results concerning the stability of equilibria of a delay differential equation modeling leukemia

    CERN Document Server

    Ion, Anca Veronica

    2010-01-01

    The paper is devoted to the study of stability of equilibrium solutions of a delay differential equation that models leukemia. The equation was previously studied in [5] and [6], where the emphasis is put on the numerical study of periodic solutions. Some stability results for the equilibria are also presented in these works, but they are incomplete and contain some errors. Our work aims to complete and to bring corrections to those results. Both Lyapunov first order approximation method and second Lyapunov method are used.

  3. Bridgman's concern

    International Nuclear Information System (INIS)

    In 1956 P.W. Bridgman published a letter to the editor in the Journal of Applied Physics reporting results of electrical resistance measurements on iron under static high pressure. The work was undertaken to verify the existence of a polymorphic phase transition at 130 kbar (13 GPa) reported in the same journal and year by the Los Alamos authors, Bancroft, Peterson and Minshall for high pressure, shock-compression loading. In his letter, Bridgman reported that he failed to find any evidence for the transition. Further, he raised some fundamental concerns as to the state of knowledge of shock-compression processes in solids. Later it was determined that Bridgman's static pressure scale was in error, and the shock observations became the basis for calibration of pressure values in static high pressure apparatuses. In spite of the error in pressure scales, Bridgman's concerns on descriptions of shock-compression processes were perceptive and have provided the basis for subsequent fundamental studies of shock-compressed solids. The present paper, written in response to receipt of the 1993 American Physical Society Shock-Compression Science Award, provides a brief contemporary assessment of those shock-compression issues which were the basis of Bridgman's 1956 concerns

  4. Flawed Assumptions, Models and Decision Making: Misconceptions Concerning Human Elements in Complex System

    Energy Technology Data Exchange (ETDEWEB)

    FORSYTHE,JAMES C.; WENNER,CAREN A.

    1999-11-03

    The history of high consequence accidents is rich with events wherein the actions, or inaction, of humans was critical to the sequence of events preceding the accident. Moreover, it has been reported that human error may contribute to 80% of accidents, if not more (dougherty and Fragola, 1988). Within the safety community, this reality is widely recognized and there is a substantially greater awareness of the human contribution to system safety today than has ever existed in the past. Despite these facts, and some measurable reduction in accident rates, when accidents do occur, there is a common lament. No matter how hard we try, we continue to have accidents. Accompanying this lament, there is often bewilderment expressed in statements such as, ''There's no explanation for why he/she did what they did''. It is believed that these statements are a symptom of inadequacies in how they think about humans and their role within technological systems. In particular, while there has never been a greater awareness of human factors, conceptual models of human involvement in engineered systems are often incomplete and in some cases, inaccurate.

  5. Issues for Achieving an Experimental Model Concerning Bubble Deck Concrete Slab with Spherical Gaps

    Directory of Open Access Journals (Sweden)

    Sergiu Călin

    2010-01-01

    Full Text Available After realizing numerous constructions in the world, which use Bubble Deck concrete slabs with spherical gaps, valuable information were gathered, allowing a rigorous processing and systematization, with the purpose of realizing an experimental and documentary study. The paper presents some experimental programs which refer to concrete slabs with spherical gaps, existing in similar execution and loading conditions as those from a real construction; this implies the realization of a monolithic slab element at a scale of 1:1, which will be subjected to static gravitational loadings in order to determine the deformation (deflection, cracking and failing characteristics. The resultant conclusions will be used in defining the failing mechanisms, very useful in the formulation of an adequate mathematical model. The research proposed in the project offers an answer to the major objectives of the development of calculus methods and existent prescriptions of the concrete slabs with spherical gaps. The realization of the proposed objectives involves documentation activities, theoretical study, collaboration with different other partners, gathering and processing of the results obtained in laboratory and even in situ.

  6. Model calculations concerning rotation at high solar latitudes and the depth of the solar convection zone

    International Nuclear Information System (INIS)

    The author has previously carried out extensive nonlinear numerical simulations of convection in a rotating spherical shell, motivated by the problem of understanding the Sun's differential rotation. The polar vortex found in earlier calculations, but not observed on the Sun, disappears when shell depths as large as 40% of the radius are assumed. The equatorial acceleration is also enhanced, producing a closer fit to solar observations than previous calculations for depths of 20%. The reasons for the disappearance of the polar vortex are that in deeper layers the Reynolds stresses, which transport angular momentum toward the equator to form the equatorial acceleration, reach to higher latitudes, and the moment of inertia of the polar cap region is a smaller fraction of the total for the shell. Although the model used is for a stratified liquid (the Boussinesq approximation), we argue that deep layers are less likely to have a polar vortex than shallow ones in the compressible case too. This result favors a solar convection zone substantially deeper than previously inferred from stellar structure calculations applied to the Sun, but is consistent with recent inferences of a deep convection zone made from measurements of solar oscillations

  7. The Buffalo Model: Shifting the Focus of Clinical Licensure Exams in Dentistry to Address Ethical Concerns Regarding Patient Care.

    Science.gov (United States)

    Gambacorta, Joseph E; Glick, Michael; Anker, Ashley E; Shampaine, Guy S

    2016-06-01

    Most jurisdictions grant dental licensure to graduating students following successful completion of a clinical exam. Testing agencies, which are independent of dental schools, nevertheless conduct their exams at school facilities. Patient participation in these exams raises ethical concerns regarding such issues as unlicensed providers' performing irreversible procedures with minimal supervision and graduates' limited accessibility to provide follow-up treatment. To address these concerns, a collaborative effort between University at Buffalo School of Dental Medicine faculty and testing agency personnel was launched. The aims of this article are to describe the development and implementation of the resulting Buffalo Model, to highlight ethical advantages in its application, and to identify areas of improvement to be addressed in future iterations. With the Buffalo Model, modifications were made to the traditional exam format in order to integrate the exam into the school curriculum, enabling candidates to take it at various points during their fourth year. In addition, after calibration of school faculty members, 98.5% of cases verified by faculty were accepted by the Commission on Dental Competency Assessments for use in the exam. In two cases, restorative treatment completed during the exam did not meet the school's competency standard. This new approach ameliorates ethical concerns associated with clinical licensure exams because treatment is provided only to patients of record within a sequenced treatment plan and timely and appropriate treatment is provided to all patients. The results of this first year of implementation also suggest that calibrated faculty members will not show bias in the selection of lesions or competency evaluations of candidates. PMID:27251344

  8. STUDENT'S SCIENCE MISCONCEPTIONS CONCERNING THE STATE CHANGES OF WATER AND THEIR REMEDIATION USING THREE DIFFERENT LEARNING MODELS IN ELEMENTARY SCHOOL

    Directory of Open Access Journals (Sweden)

    M. Taufiq

    2012-05-01

    Full Text Available Secara umum, kesalahpahaman yang dialami oleh mahasiswa dapat menyebabkan kesulitan dalam penelitian, sementara anakanakmemiliki kesadaran mereka sendiri. Tingkat kesalahpahaman yang dialami oleh siswa juga tidak sama, dalam kasus inisesuatu mengalami kesalahpahaman pengalaman tingkat tinggi, menengah, dan rendah. Untuk alasan itu, siswa memerlukanmodel pembelajaran yang tepat untuk masing-masing tingkat kesalahpahaman yang dialami untuk membuat studi menjadibermakna. Dalam makalah ini, peneliti mengeksplorasi informasi tentang; (1 tingkat kesalahpahaman ilmu siswa tentangperubahan wujud dari air, dan (2 model pembelajaran yang paling efektif untuk mengatasi kesalahpahaman siswa mengenaiperubahan wujud air. Model pembelajaran tiga dalam penelitian ini adalah: siklus belajar, penyelidikan dipandu, dan model konseppemetaan. Metode yang diterapkan dalam penelitian ini adalah wawancara klinis dan pretest-posttest. Informasi yangdikumpulkan dianalisis secara kuantitatif dengan percobaan uji ANOVA dan keuntungan rata-rata normal dihitung untuk setiapkelompok percobaan. In general, misconceptions experienced by student could cause difficulties in study, meanwhile children have their own sense.Level of misconceptions experienced by student also unequal, in this case something experiences high level misconceptions,medium, and low. For that reason, student requires correct learning model for each level of misconception experienced to make thestudy become meaningful. In this paper, the researcher explored information about; (1 the level of science misconceptions of thestudent concerning the state changes of water, and (2 the most effective learning model to remedy student's misconceptionsconcerning the state changes of water. The three learning models in this research are: learning cycle, guided inquiry, and conceptmapping model. The method applied in this research is the clinical interview and pretest-posttest. The information collected wasanalyzed in

  9. Modeling transport and deposition of contaminants to ecosystems of concern: a case study for the Laurentian Great Lakes

    International Nuclear Information System (INIS)

    Transfer efficiency (TE) is introduced as a model output that can be used to characterize the relative ability of chemicals to be transported in the environment and deposited to specific target ecosystems. We illustrate this concept by applying the Berkeley-Trent North American contaminant fate model (BETR North America) to identify organic chemicals with properties that result in efficient atmospheric transport and deposition to the Laurentian Great Lakes. By systematically applying the model to hypothetical organic chemicals that span a wide range of environmental partitioning properties, we identify combinations of properties that favor efficient transport and deposition to the Lakes. Five classes of chemicals are identified based on dominant transport and deposition pathways, and specific examples of chemicals in each class are identified and discussed. The role of vegetation in scavenging chemicals from the atmosphere is assessed, and found to have a negligible influence on transfer efficiency to the Great Lakes. Results indicate chemicals with octanol-water (Kow) and air-water (Kaw) partition coefficients in the range of 105-107 and 10-4-10-1 combine efficient transport and deposition to the Great Lakes with potential for biaccumulation in the aquatic food web once they are deposited. A method of estimating the time scale for atmospheric transport and deposition process is suggested, and the effects of degrading reactions in the atmosphere and meteorological conditions on transport efficiency of different classes of chemicals are discussed. In total, this approach provides a method of identifying chemicals that are subject to long-range transport and deposition to specific target ecosystems as a result of their partitioning and persistence characteristics. Supported by an appropriate contaminant fate model, the approach can be applied to any target ecosystem of concern. - Transfer Efficiency is defined as a model-based measure of sources of POPs to the North

  10. Modelling compressible multiphase flows Quelques résultats concernant la modélisation des écoulements multiphasiques

    Directory of Open Access Journals (Sweden)

    Coquel Frédéric

    2013-07-01

    Full Text Available We give in this paper a short review of some recent achievements within the framework of multiphase flow modeling. We focus first on a class of compressible two-phase flow models, detailing closure laws and their main properties. Next we briefly summarize some attempts to model two-phase flows in a porous region, and also a class of compressible three-phase flow models. Some of the main difficulties arising in the numerical simulation of solutions of these complex and highly non-linear systems of PDEs are then discussed, and we eventually show some numerical results when tackling two-phase flows with mass transfer. Nous présentons dans cet article quelques résultats récents concernant la modélisation et la simulation numérique des écoulements multiphasiques. Nous nous concentrons tout d’abord sur une classe de modèles diphasiques compressibles, en détaillant les lois de fermeture et les principales propriétés du sytème. Nous résumons ensuite brièvement les propositions de modélisation d’écoulements diphasiques en milieu poreux et d’écoulements triphasiques. Quelques difficultés apparaissant dans la simulation numérique de ces modèles sont présentées, et des résultats récents comportant un transfert de masse entre phases sont finalement décrits.

  11. Results of a modeling workshop concerning economic and environmental trends and concomitant resource management issues in the Mobile Bay area

    Science.gov (United States)

    Hamilton, David B.; Andrews, Austin K.; Auble, Gregor T.; Ellison, Richard A.; Johnson, Richard A.; Roelle, James E.; Staley, Michael J.

    1982-01-01

    During the past decade, the southern regions of the U.S. have experienced rapid change which is expected to continue into the foreseeable future. Growth in population, industry, and resource development has been attributed to a variety of advantages such as an abundant and inexpensive labor force, a mild climate, and the availability of energy, water, land, and other natural resources. While this growth has many benefits for the region, it also creates the potential for increased air, water, and solid waste pollution, and modification of natural habitats. A workshop was convened to consider the Mobile Bay area as a site-specific case of growth and its environmental consequences in the southern region. The objectives of the modeling workshop were to: (1) identify major factors of economic development as they relate to growth in the area over the immediate and longer term; (2) identify major environmental and resource management issues associated with this expected growth; and (3) identify and characterize the complex interrelationships among economic and environmental factors. This report summarizes the activities and results of a modeling workshop concerning economic growth and concomitant resource management issues in the Mobile Bay area. The workshop was organized around construction of a simulation model representing the relationships between a series of actions and indicators identified by participants. The workshop model had five major components. An Industry Submodel generated scenarios of growth in several industrial and transportation sectors. A Human Population/Economy Submodel calculated human population and economic variables in response to employment opportunities. A Land Use/Air Quality Submodel tabulated changes in land use, shoreline use, and air quality. A Water Submodel calculated indicators of water quality and quantity for fresh surface water, ground water, and Mobile Bay based on discharge information provided by the Industry and Human

  12. A Directed Binding Mechanism of Processive Motion for the Kinesin Motor Protein Families

    International Nuclear Information System (INIS)

    A novel physical mechanism is discussed for the processive propagation of two-headed motor proteins such as kinesin along protein filaments. Our model uses the fact that the binding of each head must be directionality oriented to the protein filament. The binding sites are realized by a 2D periodic potential due to the filament's surface. The deviation of the geometry of the kinesin from the relaxed state to the state where both motor domains are simultaneously bound to the filament results in an internal stress of the molecule. Un-binding of one of the motor domains from the filament, which is due to the release of chemical energy from ATP hydrolysis, results in a mechanical movement until the relaxed state is reached again. We develop a simple mathematical and mechanical model in which directed binding of the heads to the filament results in a directed twist away from its relaxed state of the molecule, occurring probably in the neck linker region. Un-binding of the head from the filament relaxes the twist and defines the propagation direction. We show that there must be at least one torsional spring for every head to store elastic energy. It is the internal structure both of the relaxed and tensed-up state that defines the walking direction of kinesin. Calculations based on the model are in good quantitative agreement with experimental observations. (author)

  13. A Directed Binding Mechanism of Processive Motion for the Kinesin Motor Protein Families

    Science.gov (United States)

    Bolterauer, H.; Tuszynski, J. A.; Unger, E.

    2006-05-01

    A novel physical mechanism is discussed for the processive propagation of two-headed motor proteins such as kinesin along protein filaments. Our model uses the fact that the binding of each head must be directionality oriented to the protein filament. The binding sites are realized by a 2D periodic potential due to the filament's surface. The deviation of the geometry of the kinesin from the relaxed state to the state where both motor domains are simultaneously bound to the filament results in an internal stress of the molecule. Un-binding of one of the motor domains from the filament, which is due to the release of chemical energy from ATP hydrolysis, results in a mechanical movement until the relaxed state is reached again. We develop a simple mathematical and mechanical model in which directed binding of the heads to the filament results in a directed twist away from its relaxed state of the molecule, occurring probably in the neck linker region. Un-binding of the head from the filament relaxes the twist and defines the propagation direction. We show that there must be at least one torsional spring for every head to store elastic energy. It is the internal structure both of the relaxed and tensed-up state that defines the walking direction of kinesin. Calculations based on the model are in good quantitative agreement with experimental observations.

  14. The Architecture of the Statistical Modeling Concerning the Consumer Prices Indexes for Food Goods, Non-Food Goods and Services, in Romania

    OpenAIRE

    Gabriela OPAIT

    2014-01-01

    This paper reflects the econometric modeling between 2000-2013, in Romania, concerning the Consumer Prices Index for food goods, the Consumer Prices Index for non-food goods and the Consumer Prices Index for services, through by means of the „Least Squares Method”. The Consumer Prices Index (CPI) reflects the change of price concerning the basket of goods that it is supposed to be purchased by a urban consumers in terms of the expenses incurred by a typical household.

  15. Biosorption behaviors of uranium (VI) from aqueous solution by sunflower straw and insights of binding mechanism

    International Nuclear Information System (INIS)

    Uranium (VI)-containing water has been recognized as a potential longer-term radiological health hazard. In this work, the sorptive potential of sunflower straw for U (VI) from aqueous solution was investigated in detail, including the effect of initial solution pH, adsorbent dosage, temperature, contact time and initial U (VI) concentration. A dose of 2.0 g L-1 of sunflower straw in an initial U (VI) concentration of 20 mg L-1 with an initial pH of 5.0 and a contact time of 10 h resulted in the maximum U (VI) uptake (about 6.96 mg g-1) at 298 K. The isotherm adsorption data was modeled best by the nonlinear Langmuir-Freundlich equation. The equilibrium sorption capacity of sunflower straw was observed to be approximately seven times higher than that of coconut-shell activated carbon as 251.52 and 32.37 mg g-1 under optimal conditions, respectively. The positive enthalpy and negative free energy suggested the endothermic and spontaneous nature of sorption, respectively. The kinetic data conformed successfully to the pseudo-second-order equation. Furthermore, energy dispersive X-ray, fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy demonstrated that U (VI) adsorption onto sunflower straw was predominantly controlled by ion exchange as well as complexation mechanism. The study revealed that sunflower straw could be exploited for uranium remediation of aqueous streams as a promising adsorbent. (author)

  16. Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.

    Science.gov (United States)

    Liu, Weidong; Guo, Rey-Ting; Chen, Xi; Li, Zhe; Gao, Xiuzhen; Huang, Chun-Hsiang; Wu, Qiaqing; Feng, Jinhui; Zhu, Dunming

    2015-04-13

    A meso-diaminopimelate dehydrogenase (DAPDH) from Clostridium tetani E88 (CtDAPDH) was found to have low activity toward the D-amino acids other than its native substrate. Site-directed mutagenesis similar to that carried out on the residues mutated by Vedha-Peters et al. resulted in a mutant enzyme with highly improved catalytic ability for the synthesis of D-amino acids. The crystal structures of the CtDAPDH mutant in apo form and in complex with meso-diaminopimelate (meso-DAP), D-leucine (D-leu), and 4-methyl-2-oxopentanoic acid (MOPA) were solved. meso-DAP was found in an area outside the catalytic cavity; this suggested a possible two-step substrate-binding mechanism for meso-DAP. D-leu and MOPA each bound both to Leu154 and to Gly155 in the open form of CtDAPDH, and structural analysis revealed the molecular basis for the expanded substrate specificity of the mutant meso-diaminopimelate dehydrogenases. PMID:25754803

  17. Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays.

    Science.gov (United States)

    Tzoupis, Haralambos; Leonis, Georgios; Avramopoulos, Aggelos; Reis, Heribert; Czyżnikowska, Żaneta; Zerva, Sofia; Vergadou, Niki; Peristeras, Loukas D; Papavasileiou, Konstantinos D; Alexis, Michael N; Mavromoustakos, Thomas; Papadopoulos, Manthos G

    2015-11-01

    We investigate the binding mechanism in renin complexes, involving three drugs (remikiren, zankiren and enalkiren) and one lead compound, which was selected after screening the ZINC database. For this purpose, we used ab initio methods (the effective fragment potential, the variational perturbation theory, the energy decomposition analysis, the atoms-in-molecules), docking, molecular dynamics, and the MM-PBSA method. A biological assay for the lead compound has been performed to validate the theoretical findings. Importantly, binding free energy calculations for the three drug complexes are within 3 kcal/mol of the experimental values, thus further justifying our computational protocol, which has been validated through previous studies on 11 drug-protein systems. The main elements of the discovered mechanism are: (i) minor changes are induced to renin upon drug binding, (ii) the three drugs form an extensive network of hydrogen bonds with renin, whilst the lead compound presented diminished interactions, (iii) ligand binding in all complexes is driven by favorable van der Waals interactions and the nonpolar contribution to solvation, while the lead compound is associated with diminished van der Waals interactions compared to the drug-bound forms of renin, and (iv) the environment (H2O/Na(+)) has a small effect on the renin-remikiren interaction. PMID:26421414

  18. Altruism and Career Concerns

    OpenAIRE

    Shchetinin, Oleg

    2009-01-01

    The paper studies the impact of altruism on Agent’s motivation in the career concerns model. The paper shows the new channel of interaction between intrinsic and extrinsic motivation. The common point in the literature is that intrinsic motivation can be crowded out by the extrinsic incentives. My paper shows that crowding effect can go in the opposite direction: extrinsic incentives can be lessened for the intrinsically motivated agent. The analysis shows that altruism can decrease effort, t...

  19. Analisis Respon Auditor Terhadap Asumsi Going Concern Akibat Krisis Moneter Dan Financial Distres Model (Study Kasus Pada Perusahaan Di BEI Yang Mengalami Kerugian

    Directory of Open Access Journals (Sweden)

    Abby Seno Higar

    2014-03-01

    Full Text Available Penelitian ini menguji tentang respon auditor terhadap askumsi going concern pada saat krisis moneter dan financial distress model. Tujuan dari penelitian ini adalah untuk menguji apakah respon dari kedua situasi diatas berbeda atau sama. Sampel dari penelitian ini adalah perusahaan yang terdaftar di Bursa Efek Indonesia (BEI pada tahun 2007-2009 yang mengalami penurunan laba selama 2 tahun berturut-turut. Hasil dari penelitian ini pada pengujian di tahun 2008 menghasilkan kesimpulan bahwa semua kelompok berbeda, namun pada tahun 2009 ada kelompok yang sama. Dan pada tahun 2008 dan 2009 hasilnya berbeda juga respon yang diberikan.JEL Classification : M0, M42Keywords : Respon Auditor, Asumsi Going Concern, krisis moneter, Financial Distress Model.

  20. Nearest-neighbor non-additivity versus long-range non-additivity in TATA-box structure and its implications for TBP-binding mechanism

    OpenAIRE

    Faiger, Hana; Ivanchenko, Marina; Haran, Tali E.

    2007-01-01

    TBP recognizes its target sites, TATA boxes, by recognizing their sequence-dependent structure and flexibility. Studying this mode of TATA-box recognition, termed ‘indirect readout’, is important for elucidating the binding mechanism in this system, as well as for developing methods to locate new binding sites in genomic DNA. We determined the binding stability and TBP-induced TATA-box bending for consensus-like TATA boxes. In addition, we calculated the individual information score of all st...

  1. Using the Deficit Model, Public Debate Model and Co-Production of Knowledge Models to Interpret Points of View of Students Concerning Citizens' Participation in Socioscientific Issues

    Science.gov (United States)

    Pouliot, Chantal

    2009-01-01

    In the first part of this article I propose a conceptual framework--based on the deficit, public debate and co-production of knowledge models articulated by (Callon, 1999)--with which to examine students' appropriation of de socioscientific issues (SSI). The second part of this article presents the way a group of three…

  2. A mathematical model concerned in self-absorption correction to calibrate detection efficiency of the Ge gamma-ray spectrometer

    International Nuclear Information System (INIS)

    A self-absorption correction function used for cylindrical samples with different density in the Gamma-ray spectrum analysis is reported. The effects of the Gamma-ray energy and sample density on the self-absorption are unitized in the function model, and so a shortcut for detection efficiency calibration in the Gamma-ray spectrum analysis is found

  3. On merging business process management and geographic information systems: modeling and execution of ecological concerns in processes

    OpenAIRE

    Zhu, X.; Zhu, G; vanden Broucke, Seppe; Recker, J.

    2014-01-01

    Business Process Management describes a holistic management approach for the systematic design, modeling, execution, validation, monitoring and improvement of organizational business processes. Traditionally, most attention within this community has been given to control-flow aspects, i.e., the ordering and sequencing of business activities, oftentimes in isolation with regards to the context in which these activities occur. In this paper, we propose an approach that allows executable process...

  4. Periodicity and Permanence of a Discrete Impulsive Lotka-Volterra Predator-Prey Model Concerning Integrated Pest Management

    Directory of Open Access Journals (Sweden)

    Chang Tan

    2013-01-01

    Full Text Available By piecewise Euler method, a discrete Lotka-Volterra predator-prey model with impulsive effect at fixed moment is proposed and investigated. By using Floquets theorem, we show that a globally asymptotically stable pest-eradication periodic solution exists when the impulsive period is less than some critical value. Further, we prove that the discrete system is permanence if the impulsive period is larger than some critical value. Finally, some numerical experiments are given.

  5. Periodicity and Permanence of a Discrete Impulsive Lotka-Volterra Predator-Prey Model Concerning Integrated Pest Management

    OpenAIRE

    Chang Tan; Jun Cao

    2013-01-01

    By piecewise Euler method, a discrete Lotka-Volterra predator-prey model with impulsive effect at fixed moment is proposed and investigated. By using Floquets theorem, we show that a globally asymptotically stable pest-eradication periodic solution exists when the impulsive period is less than some critical value. Further, we prove that the discrete system is permanence if the impulsive period is larger than some critical value. Finally, some numerical experiments are given.

  6. Application of model-driven techniques to the design of non-functional concerns of service-oriented software systems

    OpenAIRE

    Silva Gallino, Juan Pedro

    2012-01-01

    Internet se ha convertido en la herramienta por excelencia para el intercambio de servicios de negocio e información entre empresas. En este contexto, las arquitecturas orientadas a servicios (SOA) y los servicios web (WS) han surgido como la plataforma más apropiada para las interacciones aplicación-aplicación. Por otra parte, el desarrollo guiado por modelos (MDD), y Model-Driven Architecture (MDA) en particular, son nuevos paradigmas que promueven el uso de modelos del sistema como element...

  7. The Six concerns for Separation of Concerns

    OpenAIRE

    Aksit, Mehmet; Tekinerdogan, Bedir; Bergmans, Lodewijk

    2001-01-01

    Despite a common agreement on the necessity of the application of the separation of concerns (SOC) principle, there is not yet a consensus for its key issues. The separation of the concerns is usually based on the adopted programming paradigm, the applied method or even the programming language. This paper presents the so-called six ‘C’ properties that can be applied as a guideline for defining and evaluating the approaches that adopt the SOC principle.

  8. Interrelationships between densitometric, geometric, and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling.

    Science.gov (United States)

    Ferretti, J L; Capozza, R F; Mondelo, N; Zanchetta, J R

    1993-11-01

    A compensation for differences in bone material quality by bone geometric properties in femora from two different strains of rats was previously shown by us. A feedback mechanism controlling the mechanical properties of the integrated bones was then proposed, in accordance with Frost's mechanostat theory. Evidence of such a system is now offered by the finding of a negative correlation between the modeling-dependent cross-sectional architecture (moment of inertia) and the mineral-dependent stiffness (elastic modulus) of bone material in the femoral diaphyses of 45 normal Wistar rats of different sexes, ages, and sizes. The strength and stiffness of the integrated diaphyses were found to depend on both cross-sectional inertia and body weight, not on bone mineral density. These findings are interpreted as supporting the hypothesis that the architectural efficiency of diaphyseal cross-sectional design resulting from the spatial orientation of bone modeling during growth is optimized as a function of the body weight-dependent bone strain history, within the constraints imposed by bone stiffness. Results suggest a modulating role of biomass, related to the system set point determination, and explain the usually observed lack of a direct correlation between mineral density and strength or stiffness of long bones in studies of geometrically inhomogeneous populations. PMID:8266830

  9. Application of chemometric methods for assessment and modelling of microbiological quality data concerning coastal bathing water in Greece

    Directory of Open Access Journals (Sweden)

    Agelos Papaioannou

    2014-12-01

    Full Text Available Background. Worldwide, the aim of managing water is to safeguard human health whilst maintaining sustainable aquatic and associated terrestrial, ecosystems. Because human enteric viruses are the most likely pathogens responsible for waterborne diseases from recreational water use, but detection methods are complex and costly for routine monitoring, it is of great interest to determine the quality of coastal bathing water with a minimum cost and maximum safety. Design and methods. This study handles the assessment and modelling of the microbiological quality data of 2149 seawater bathing areas in Greece over 10-year period (1997-2006 by chemometric methods. Results. Cluster analysis results indicated that the studied bathing beaches are classified in accordance with the seasonality in three groups. Factor analysis was applied to investigate possible determining factors in the groups resulted from the cluster analysis, and also two new parameters were created in each group; VF1 includes E. coli, faecal coliforms and total coliforms and VF2 includes faecal streptococci/enterococci. By applying the cluster analysis in each seasonal group, three new groups of coasts were generated, group A (ultraclean, group B (clean and group C (contaminated. Conclusions. The above analysis is confirmed by the application of discriminant analysis, and proves that chemometric methods are useful tools for assessment and modeling microbiological quality data of coastal bathing water on a large scale, and thus could attribute to effective and economical monitoring of the quality of coastal bathing water in a country with a big number of bathing coasts, like Greece.

  10. A Non-Linear Digital Computer Model Requiring Short Computation Time for Studies Concerning the Hydrodynamics of the BWR

    International Nuclear Information System (INIS)

    This non-linear model serves as one of the blocks in a series of codes to study the transient behaviour of BWR or PWR type reactors. This program is intended to be the hydrodynamic part of the BWR core representation or the hydrodynamic part of the PWR heat exchanger secondary side representation. The equations have been prepared for the CSMP digital simulation language. By using the most suitable integration routine available, the ratio of simulation time to real time is about one on an IBM 360/75 digital computer. Use of the slightly different language DSL/40 on an IBM 7044 computer takes about four times longer. The code has been tested against the Eindhoven loop with satisfactory agreement

  11. A model for organizing and analyzing integration of environmental concerns in product design and re-design

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard

    2014-01-01

    problems addressed by the product and the solution it is offering. 2) A system’s perspective which implies a focus on the system, which a product is part of, including the need for supporting infrastructures like stakeholder training, waste management etc. 3) A lifecycle perspective to environmental......Based on examples from research and innovation within nanotechnology, housing, bioenergy, and clothing the complexity of environmental innovation is discussed. A model for a more holistic approach to environmental innovation, which can be used both as part of innovation processes and for analyses...... of previous innovation processes, is developed. The approach is based on: 1) A scenario perspective on environmental aspects and impacts which implies a focus on the future roles of a product, its users and the surrounding society as imagined by the designers in their considerations about the...

  12. Experience in biosphere modelling and definition of exposed groups. Concerns on consideration of the long-term

    International Nuclear Information System (INIS)

    The long life of high level waste and their 'possible' releases, from the repository, in the far future during wide time frames, introduce difficulties on the ability of forecasting actual doses. Similar difficulties were found when trying to establish or recommend protection criteria for the environment and human health. The stochastic nature of the whole problem, from the causes that initiate radionuclides releases to the nature of the environmental conditions where impact is evaluated, made more complex the treatment of the radionuclide transport models and the analysis of radiological impact. The application of radiological protection principles to this management option, was also seen as different from other present-day practices. All this gave rise to the diversification of the research lines towards new areas that allow for the analysis of radionuclide transport, dose calculations and, criteria, in this new situation. The approach for the biosphere system based on the 'reference' concept, in essence the same idea as the one for the 'Reference man' concept, was promoted internationally, first within the BIOMOVS II Project and, afterwards, in the BIOMASS IAEA Programme. In parallel to the participation in these Projects and based on their conclusions, CIEMAT has been developing for ENRESA a methodology, which has to be updated and completed with recent developments from BIOMASS-Theme1. Notably, for the Justification and Identification step, the Description of Critical Groups and the use of the Data protocol. An application of this methodology was performed and published in 1998 and, its results and conclusions are summarised in the paper. Also, the paper includes main conclusions from the biosphere modelling applied in the last ENRESA2000 Spanish PA exercise and, difficulties found in the consistency between the scenario generation procedure, the treatment of the interface and the source term and, the use of the reference biosphere concept. (author)

  13. Suitable Assimilation Model of Culture, Beliefs and Rites Concerning Deities of Buddhism and Hindu-Brahmanism for Peace of Thai Society in Bangkok and Circumferences

    Directory of Open Access Journals (Sweden)

    Phra M.K. Kaewchaiya

    2011-01-01

    Full Text Available Problem statement: At present, Thai society widely assimilates culture, beliefs and rites concerning deities of Buddhism and Hindu-Brahmanism by worshipping the deity images at the temples or the abodes of gods in Bangkok and circumferences. A typical worship is to pray the deity for help. As a matter of fact, people should help themselves first and use a prayer as willpower. The purpose of this research were these; (1 to investigate the background of culture, belief and rites concerning deities of Buddhism and Hindu-Brahmanism in Bangkok and circumferences, (2 to investigate the current situations of the assimilation of culture, beliefs and rites concerning deities of Buddhism and Hindu-Brahmanism in Bangkok and circumferences and (3 to determine a suitable assimilation model of culture beliefs and rite concerning deities of Buddhism and Hindu-Brahmanism for peace of Thai society in Bangkok and circumferences. Approach: A qualitative research was used for this research. Research areas were these: (1 Yannawa Temple, Yannawa sub district, Sathon district, Bangkok, (2 Lum Charoen Satta Temple, Yannawa sub district, Sathon district, Bangkok, (3 Brahma House at the Erawan Hotel, Lum Phini sub district, Pathumwan district , Bangkok, (4 Phai Lom Temple, Phra Pathom Chedi, Muang district, Nakhon Pathom Province, (5 Sisa Thong Temple, Sisa Thong sub district, Nakhon Chaisi, Nakhon Pathom Province, (6 Phra Sri Maha Uma Thewi Temple, Silom sub district, Bangkok district, Bangkok, (7 Visanu temple, Thung Wat Don sub district, Sathon district, Bangkok, (8 Thep Nimit Temple, Khok Phaed sub district, Nong Chok district, Bangkok, (9 Brahman Temple, Sao Chingcha sub district, Phra Nakhon district, Bangkok and (10 Ganesha House at Ratchada crossroads, Huay Khwang district, Bangkok. Deity worships have been held at these areas for a long time and a lot of people have participated in these worships. A population was the people who lived in 9 districts. A sample

  14. Empathic concern drives costly altruism

    OpenAIRE

    FeldmanHall, Oriel; Dalgleish, Tim; Evans, Davy; Mobbs, Dean

    2015-01-01

    Why do we self-sacrifice to help others in distress? Two competing theories have emerged, one suggesting that prosocial behavior is primarily motivated by feelings of empathic other-oriented concern, the other that we help mainly because we are egoistically focused on reducing our own discomfort. Here we explore the relationship between costly altruism and these two sub-processes of empathy, specifically drawing on the caregiving model to test the theory that trait empathic concern (e.g. gene...

  15. Elucidating the structures and cooperative binding mechanism of cesium salts to the multitopic ion-pair receptor through density functional theory calculations.

    Science.gov (United States)

    Sadhu, Biswajit; Sundararajan, Mahesh; Velmurugan, Gunasekaran; Venuvanalingam, Ponnambalam

    2015-09-21

    Designing new and innovative receptors for the selective binding of radionuclides is central to nuclear waste management processes. Recently, a new multi-topic ion-pair receptor was reported which binds a variety of cesium salts. Due to the large size of the receptor, quantum chemical calculations on the full ion-pair receptors are restricted, thus the binding mechanisms are not well understood at the molecular level. We have assessed the binding strengths of various cesium salts to the recently synthesized multi-topic ion-pair receptor molecule using density functional theory based calculations. Our calculations predict that the binding of cesium salts to the receptor predominantly occurs via the cooperative binding mechanism. Cesium and the anion synergistically assist each other to bind favorably inside the receptor. Energy decomposition analysis on the ion-pair complexes shows that the Cs salts are bound to the receptor mainly through electrostatic interactions with small contribution from covalent interactions for large ionic radius anions. Further, QTAIM analysis characterizes the importance of different inter-molecular interactions between the ions and the receptor inside the ion-pair complexes. The role of the crystallographic solvent molecule contributes significantly by ~10 kcal mol(-1) to the overall binding affinities which is quite significant. Further, unlike the recent molecular mechanics (MM) calculations, our calculated binding affinity trends for various Cs ion-pair complexes (CsF, CsCl and CsNO3) are now in excellent agreement with the experimental binding affinity trends. PMID:26227949

  16. Food Concerns. Research Notes.

    Science.gov (United States)

    Jordan, Debra J.

    1998-01-01

    Adolescent vegetarianism is most frequent among females, and involves meat avoidance, concern for the environment and animal welfare, gender equality, weight loss behaviors, and a concern with body appearance. It can be a precursor to eating disorders. Training and ongoing follow-up are necessary to instill proper food handling procedures in…

  17. Do Privacy Concerns Matter for Millennials?

    DEFF Research Database (Denmark)

    Fodor, Mark; Brem, Alexander

    2015-01-01

    data have raised the question, if location data are considered as sensitive data by users. Thus, we use two privacy concern models, namely Concern for Information Privacy (CFIP) and Internet Users’ Information Privacy Concerns (IUIPC) to find out. Our sample comprises of 235 individuals between 18 and...... dimensions may play a role in determining usage intention, which should be analyzed by further research....

  18. DYNAMICAL ANALYSIS OF BANDA SEA CONCERNING WITH EL NINO, INDONESIAN THROUGH FLOW AND MONSOON BY USING SATELLITE DATA AND NUMERICAL MODEL

    Directory of Open Access Journals (Sweden)

    Bambang Sukresno

    2012-11-01

    Full Text Available Banda sea is subjected to external force such as El Nino South Oscillation (ENSO, Indonesian Through Flow (ITF andMonsoon. All of these component Combined with Current System, caused sea dynamic. This study aimed to get further knowledge aboutBanda sea dynamic. Based on this phenomenon , this study was conducted with an hypothesis that sea level anomaly (SLA and seasufrace temperature (SST will decrease during ENSO event. Also that SLA and SST will seasonally change concerning with Monsoon.The pattern of current in eastern of Banda sea will be seasonally different concerning with monsoon while in western of Banda sea isalmost constant according to ITFThis research carried out in Banda Sea within the rectangular region from 122.42 E to 131.47 E , Latitude 03.47 S to 07.65 S.in period of 1996 to 2006 consist of northwest monsoon, southeast monsoon, 1st transitional month in April and 2nd transitional monthin October. Spatial analysis used to analyze annual and seasonal distribution of SST and SLA from satellite dataset, also by comparisonbetween wind data, ITF pathway and numerical model. SST derived from NOAA / AVHRR satellite data by applying MCSST algorithm,SLA derived from Topex/ Poseidon and Jason-1 Satellite data by applying Inverse distance weighted interpolation, while numerical modelderived from barothropic model using Princeton ocean model.Sea level anomaly and sea surface temperature is decrease according to ENSO event, such as descrease of SLA and SST duringENSO event in 1997 , 2002 and 2004. Sea level anomaly and sea surface temperature is change according to Monsoon that reverse every6 (six month. SST and SLA get maximum level during northwest monsoon in November to March and get Minimum during Southeastmonsoon in May to September. There are strong correlation coefficient between annual Sea level anomaly and annual Sea SurfaceTemperature with index value up to 0.817104. on the other side correlation coefficient between seasonal Sea

  19. Positional Concerns and Institutions

    DEFF Research Database (Denmark)

    Landes, Xavier

    2013-01-01

    their implications for economics, positional concerns imply important normative dimensions. There have been presumed to be a symptom of envy, reduce people’s happiness, and create problems of social interaction or economic inefficiencies. Individuals are, for instance, prone to pick states of the world...... than others, namely that invoking envy or subjective well-being is not fully satisfying for regulating positional concerns. More compelling reasons seem, in complement with efficiency, to be related to considerations for equality. In other words, if institutions could have strong reasons to pay...... attention to and regulate positional concerns, it would be in virtue of their impact on the social product and individuals’ conditions of living....

  20. Shifts in Privacy Concerns

    OpenAIRE

    Avi Goldfarb; Catherine Tucker

    2012-01-01

    This paper explores how digitization and the associated use of customer data have affected the evolution of consumer privacy concerns. We measure privacy concerns by reluctance to disclose income in an online marketing research survey. Using over three million responses over eight years, our data show: (1) Refusals to reveal information have risen over time, (2) Older people are less likely to reveal information, and (3) The difference between older and younger people has increased over time....

  1. The Evolutive Law concerning Relationship between Economic Growth and Farmers’ Income Increase in Xinjiang since the Reform and Opening-up: An Empirical Analysis of the VEC Model

    Institute of Scientific and Technical Information of China (English)

    Xiaojun; LIU; Junsheng; DAI

    2013-01-01

    We select the per capita gross domestic product and rural residents’ per capita net income in Xinjiang as the indicator variables to measure economic growth and farmers’ income increase in Xinjiang, respectively. We establish the cointegration equation, the vector error correction (VEC) model, and use the impulse response function to conduct empirical analysis of the evolutive law concerning relationship between economic growth and farmers’ income increase in Xinjiang during the period 1978-2010. The results show that there is a cointegration relationship between economic growth in Xinjiang and farmers’ income increase; the former plays an important role in promoting the latter, following the evolutive law "first intensify, then abate, intensify again, and finally become stable". We put the following policy recommendations: providing preferential policies for farmers, scientifically and rationally guiding the transfer of rural labor; improving the function of agriculture, increasing the proportion of non-farm income; gradually bridging the widening income gap between urban and rural areas, coordinating urban and rural development.

  2. 考虑相关失效的备件优化配置模型%Allocation optimization model for spare parts concerned with dependent failures

    Institute of Scientific and Technical Information of China (English)

    周伟; 王东锋; 刘亚杰; 谭云涛; 刘晗

    2011-01-01

    相关失效普遍存在于各类系统,以传统计算独立部件的备件配置量的方法来确定相关失效部件的备件配置量,往往导致较大的误差.分析了故障源部件的备件保障水平与相关失效部件的故障率的关系,给出了考虑相关失效情况下各类部侔的备件期望短缺量与保障费用的计算方法,并以保障费用为目标,备件期望短缺量为约束提出备件优化配置模型,给出了求解该模型的算法.最后通过案例分析,验证了该模型的合理性与工程适用性.%Dependent failures exist commonly in all kinds of systems. The traditional way of independent spare parts allocation is expected to cause great errors when it is applied to the spare parts allocation with dependent failures concerned. This paper analyzes the relation between the spare parts support level of fault source parts and the failure rate of the dependent parts. Computing methods for expected backorder and support cost of various parts are put forward. Furthermore, an optimal allocation model for spare parts including its solution is proposed with cost as its object and within constraints of expected backorder quantity. Eventually, the rationality and the project applicability of this model are proved through a case study.

  3. Binding mechanism of trans-N-caffeoyltyramine and human serum albumin: Investigation by multi-spectroscopy and docking simulation.

    Science.gov (United States)

    Ma, Xiaoli; Yan, Jin; Xu, Kailin; Guo, Luiqi; Li, Hui

    2016-06-01

    trans-N-Caffeoyltyramine (TNC), which was isolated from the Cortex Lycii in our laboratory, is a phenolic amide compound with multiple pharmacological activities. The interaction between TNC and human serum albumin (HSA) was studied by Nuclear magnetic resonance (NMR) relaxation experiment, fluorescence spectroscopy, and docking simulation. NMR methodology is based on the analysis of selective and non-selective spin-lattice relaxation rate enhancements of TNC protons in the presence of the HSA. Result indicated that the interaction occurred between HSA and TNC, and changed the proton magnetic environment of TNC. Fluorescence spectroscopy confirmed that TNC displayed a strong capability to quench the fluorescence of HSA, and the acting forces for binding were hydrogen bonds and van der Waals forces. Furthermore, the circular dichroism, synchronous, and three-dimensional fluorescence spectra, which were employed to determine the conformation of protein, revealed that binding of TNC with HSA could induce conformational changes in HSA. In addition, the molecular modeling results exhibited that TNC mainly bonded to site I in sub-domain IIA of HSA. PMID:27131098

  4. Docking based 3d-QSAR studies applied at the BRAF inhibitors to understand the binding mechanism

    International Nuclear Information System (INIS)

    BRAF is a great therapeutic target in a wide variety of human cancers. It is the member of Ras Activating Factor (RAF) family of serine/throenine kinase. The mutated form of the BRAF has diverted all the attention towards itself because of increase severity and elevated kinase activity. The RAF signal transduction cascade is a conserved protein pathway that is involved in cell cycle progression and apoptosis. The ERK regulates phosphorylation of different proteins either in cytosol or in nucleus but disorders in ERK signaling pathway cause mutation in BRAF. This cascade in these cells may provide selection of mutated BRAF in which valine is substituted with glutamatic acid at position 600. This mutation occurs in activation loop. A number of inhibitors reported to target different members of RAF, some of them have potential to target the BRAF as well. Major reason for failure of previously reported inhibitors was due to the highly conserved sequence and confirmation of catalytic cleft which is always a center of consideration for binding of inhibitors to suppress the kinase activity. This is the first attempt to study and understand the BARF inhibitors - protein interactions in detail by utilizing 3D-QSAR and molecular docking techniques. Most reliable techniques of 3D QSAR i.e Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were applied for three different data sets. The data sets selected for better evaluation of BRAF inhibitors belongs to 2, 6-Disubstituted Pyrazine, Pyridoimidazolones and its derivatives. Our models would offer help to better understand the structure-activity relationships that exist for these classes of compounds and also facilitate the design of novel inhibitors with good chemical diversity. (Author)

  5. Separation of Concerns

    DEFF Research Database (Denmark)

    Ernst, Erik

    2003-01-01

    Separation of concerns is a crucial concept in discussions about software engineering consequences of programming language design decisions, especially in AOSD. This paper proposes a way to formalize this concept, and argues that the given formalization is useful even if it is used primarily in an...

  6. Quebec's Toxic Pollution Concern.

    Science.gov (United States)

    Mingie, Walter

    The best solution to the problems of increased pollution of Quebec lakes and rivers with toxic wastes and increased incidence of pollution related diseases is to educate children, to make them aware of the environment and man's interrelationship with it. Attitudes of concern, based on knowledge, must be developed so that as adults, they will take…

  7. Comment concerning Leonardo's rule

    CERN Document Server

    Sotolongo-Costa, O; Oseguera-Manzanilla, T; Díaz-Guerrero, D S

    2016-01-01

    In this comment we propose a novel explanation for the Leonardo's rule concerning the tree branching. According to Leonardo's notebooks he observed that if one observes the branches of a tree, the squared radius of the principal branch is equal to the sum of the squared radius of the branch daughters.

  8. Expression of Concern

    Science.gov (United States)

    Delvaux, Damien

    2016-08-01

    This is a note of a temporary expression of concern related to the publication titled, "Sapphirine and fluid inclusions in Tel Thanoun mantle xenoliths, Syria" by Ahmad Bilal, which appeared in Journal of African Earth Sciences, 116 (2016) 105-113.

  9. Subtleties Concerning Conformal Tractor Bundles

    CERN Document Server

    Graham, C Robin

    2012-01-01

    The realization of tractor bundles as associated bundles in conformal geometry is studied. It is shown that different natural choices of principal bundle with normal Cartan connection corresponding to a given conformal manifold can give rise to topologically distinct associated tractor bundles for the same inducing representation. Consequences for homogeneous models and conformal holonomy are described. A careful presentation is made of background material concerning standard tractor bundles and equivalence between parabolic geometries and underlying structures.

  10. Terrorism risk concern in Europe

    OpenAIRE

    Drakos, Konstantinos; Müller, Cathérine

    2011-01-01

    We explore whether differences of terrorism risk perception across all European countries reflect their underlying differences in terrorism risk, which we decompose into a long term and innovation component. We employ longitudinal country-level data on terrorism risk concern and our modeling approach is motivated by the Bayesian framework. We conclude that the observed risk perception variation is significantly explained by the long term terrorism countries face, while the cyclical part of te...

  11. Empathic concern drives costly altruism.

    Science.gov (United States)

    FeldmanHall, Oriel; Dalgleish, Tim; Evans, Davy; Mobbs, Dean

    2015-01-15

    Why do we self-sacrifice to help others in distress? Two competing theories have emerged, one suggesting that prosocial behavior is primarily motivated by feelings of empathic other-oriented concern, the other that we help mainly because we are egoistically focused on reducing our own discomfort. Here we explore the relationship between costly altruism and these two sub-processes of empathy, specifically drawing on the caregiving model to test the theory that trait empathic concern (e.g. general tendency to have sympathy for another) and trait personal distress (e.g. predisposition to experiencing aversive arousal states) may differentially drive altruistic behavior. We find that trait empathic concern--and not trait personal distress--motivates costly altruism, and this relationship is supported by activity in the ventral tegmental area, caudate and subgenual anterior cingulate, key regions for promoting social attachment and caregiving. Together, this data helps identify the behavioral and neural mechanisms motivating costly altruism, while demonstrating that individual differences in empathic concern-related brain responses can predict real prosocial choice. PMID:25462694

  12. Existential Concerns About Death

    DEFF Research Database (Denmark)

    Moestrup, Lene; Hansen, Helle Ploug

    2014-01-01

    psychology or Kübler-Ross’ theory about death stages. The complex concerns might be explained using Martin Heidegger’s phenomenological thinking. We aimed to illuminate dying patients´ existential concerns about the impending death through a descriptive analysis of semi-structured interviews with 17 cancer...... patients in Danish hospices. The main findings demonstrated how the patients faced the forthcoming death without being anxious of death but sorrowful about leaving life. Furthermore, patients expressed that they avoided thinking about death. However, some had reconstructed specific and positive ideas about...... afterlife and made accurate decisions for practical aspects of their death. The patients wished to focus on positive aspects in their daily life at hospice. It hereby seems important to have ongoing reflections and to include different theoretical perspectives when providing existential support to dying...

  13. Existential Concerns About Death

    DEFF Research Database (Denmark)

    Moestrup, Lene; Hansen, Helle Ploug

    2015-01-01

    psychology or Kübler-Ross’ theory about death stages. The complex concerns might be explained using Martin Heidegger’s phenomenological thinking. We aimed to illuminate dying patients´ existential concerns about the impending death through a descriptive analysis of semi-structured interviews with 17 cancer...... patients in Danish hospices. The main findings demonstrated how the patients faced the forthcoming death without being anxious of death but sorrowful about leaving life. Furthermore, patients expressed that they avoided thinking about death. However, some had reconstructed specific and positive ideas about...... afterlife and made accurate decisions for practical aspects of their death. The patients wished to focus on positive aspects in their daily life at hospice. It hereby seems important to have ongoing reflections and to include different theoretical perspectives when providing existential support to dying...

  14. Concern for older parts

    International Nuclear Information System (INIS)

    For the last half decade, regulatory expectations of the procurement process for nuclear commercial-grade safety-related materials have increase. The changes have been driven by concern for fraudulent or misrepresented parts and the loss of original equipment manufacturers. The industry responded to these concerns by developing improved procurement programs that changed how parts were specified and received and provided for verification of attributes that were critical to the successful performance of safety functions(s). Like its counterparts, Duquesne Light Company (DLCo), Beaver Valley power station began applying these enhanced requirements to procurements initiated after January 1, 1990, in response to the Nuclear Management and Resources Council initiative on dedication. Procurements prior to this data were not subject to the new requirements

  15. Body Image Concerns

    DEFF Research Database (Denmark)

    El Ansari, Walid; Dibba, Emily; Stock, Christiane

    2014-01-01

    AIMS: This cross-sectional study aimed to determine the socio-demographic, lifestyle and well-being variables that are associated with body image concerns (BIC) and whether these associations differed between female and male students. METHODS: A cross-sectional survey; 3,706 undergraduate students......, perceived health, depressive symptoms) on the other. RESULTS: More females (35%) than males (8%) reported being moderately or markedly concerned with their body image. For both genders, BIC was associated with a higher level of depressive symptoms and to variable extents, with nutrition and year...... (2,699 females, 765 males) from seven universities in the UK completed a self-administered questionnaire that assessed socio-demographic, lifestyle, well-being and BIC based on the Body Shape Questionnaire developed by Cooper et al. Multifactorial logistic regression analysis examined the odds ratios...

  16. The Question Concerning Thinking

    DEFF Research Database (Denmark)

    Riis, Søren

    2008-01-01

    Martin Heidegger's thought-provoking essay "The Question Concerning Technology" (1977a) placed technology at the heart of philosophy. Heidegger tried to show that the essence of technology provokes humans to think about the world in a very dangerous way. Yet if we follow Heidegger's analysis of...... technology, what role does that ascribe to philosophy? To be able to understand the programmatic scope of Heidegger's question ‘concerning' technology, we need to see it as inseparable from his famous thesis about the end of philosophy (1977c) and what he considers to be the ideal kind of thinking. However......, by doing so, we will in the end realize two important things. First, that Heidegger's declaration of the end of philosophy in fact also means the end of anything we can meaningfully call thinking. Second, that Heidegger's own thinking is completely different from his own ideal of thinking. Our...

  17. IMPORTANT CONCERN INVESTMENT MANAGEMENT

    OpenAIRE

    SINTEA (ANGHEL) LUCICA

    2014-01-01

    The issue of probabilities, uncertainties and risks has concerned society since ancient times. By probability we can see the possible realization of an act or event under certain conditions. Uncertainty is caused by emotional status of the decision maker due to more subjective factors or to the knowledge to achieve an objective. Risk is a combination of the two elements characterized by a possible description of probabilities under insecurity uncertainty conditions.

  18. IMPORTANT CONCERN INVESTMENT MANAGEMENT

    Directory of Open Access Journals (Sweden)

    SINTEA (ANGHEL LUCICA

    2014-06-01

    Full Text Available The issue of probabilities, uncertainties and risks has concerned society since ancient times. By probability we can see the possible realization of an act or event under certain conditions. Uncertainty is caused by emotional status of the decision maker due to more subjective factors or to the knowledge to achieve an objective. Risk is a combination of the two elements characterized by a possible description of probabilities under insecurity uncertainty conditions.

  19. Financial equilibrium with career concerns

    Directory of Open Access Journals (Sweden)

    Amil Dasgupta

    2006-03-01

    Full Text Available What are the equilibrium features of a financial market where a sizeable proportion of traders face reputational concerns? This question is central to our understanding of financial markets, which are increasingly dominated by institutional investors. We construct a model of delegated portfolio management that captures key features of the US mutual fund industry and embed it in an asset pricing framework. We thus provide a formal model of financial equilibrium with career concerned agents. Fund managers differ in their ability to understand market fundamentals, and in every period investors choose a fund. In equilibrium, the presence of career concerns induces uninformed fund managers to churn, i.e., to engage in trading even when they face a negative expected return. Churners act as noise traders and enhance the level of trading volume. The equilibrium relationship between fund return and net fund flows displays a skewed shape that is consistent with stylized facts. The robustness of our core results is probed from several angles.

  20. Food Safety Concerns

    Institute of Scientific and Technical Information of China (English)

    HUYONG

    2004-01-01

    In China, there is an old saying:food is the first necessity of humans. The main concern of the Chinese used to be the security of the food supply rather than the safety of the food itself. However,after a long time fighting food shortages,China became self-sufficient in food in 1995. At this time, the country began for the first time to regulate food safety. Yet China has still not established a legal systern efficient in ensuring this safety. Many problems are rooted in the administration regime and China's priority of economic development.

  1. Alignment of concerns

    DEFF Research Database (Denmark)

    Andersen, Tariq Osman; Bansler, Jørgen P.; Kensing, Finn; Moll, Jonas; Nielsen, Karen Dam

    The emergence of patient-centered eHealth systems introduces new challenges, where patients come to play an increasingly important role. Realizing the promises requires an in-depth understanding of not only the technology, but also the needs of both clinicians and patients. However, insights from...... medical phenomenology bring forth how physicians and patients focus on different aspects of illness and that they often have starkly divergent concerns. This has important implications for the design of eHealth systems that seek to engage patients as active participants. We emphasize the crucial...

  2. Concerned for Humanity club

    CERN Document Server

    Concerned for humanity club

    2010-01-01

    Join the Comité International de Soutien à Adlène Hicheur Since October 8, 2009 our colleague Adlène Hicheur, a French-Algerian physicist working in LHCb has been arrested and then held in a French prison under suspicion of terrorism linked with AQMI. No material proof has been presented, only exchanges of messages on some forum sites suspected of Islamism have been mentioned. Adlène has continuously denied any link with AQMI and lives in a Kafkaesque situation since 14 mois. His lawyer has several times asked for his release and these requests have been turned down. As Adlène’s colleagues, we have been chocked by his arrest and are deeply concerned by the prolongation of his detention for his future in particle physics, even if he will be recognized innocent. Few Concerned-club members and colleagues have created an International committee to support Adlène in his defense presently having 65 members. We invite you t...

  3. Inference Concerning Physical Systems

    Science.gov (United States)

    Wolpert, David H.

    The question of whether the universe "is" just an information- processing system has been extensively studied in physics. To address this issue, the canonical forms of information processing in physical systems - observation, prediction, control and memory - were analyzed in [24]. Those forms of information processing are all inherently epistemological; they transfer information concerning the universe as a whole into a scientist's mind. Accordingly, [24] formalized the logical relationship that must hold between the state of a scientist's mind and the state of the universe containing the scientist whenever one of those processes is successful. This formalization has close analogs in the analysis of Turing machines. In particular, it can be used to define an "informational analog" of algorithmic information complexity. In addition, this formalization allows us to establish existence and impossibility results concerning observation, prediction, control and memory. The impossibility results establish that Laplace was wrong to claim that even in a classical, non-chaotic universe the future can be unerringly predicted, given sufficient knowledge of the present. Alternatively, the impossibility results can be viewed as a non-quantum mechanical "uncertainty principle". Here I present a novel motivation of the formalization introduced in [24] and extend some of the associated impossibility results.

  4. Aesthetics of Concern

    DEFF Research Database (Denmark)

    Thorsen, Line Marie

    2013-01-01

    In the wake of Hurricane Katrina in 2005 and the tsunami that hit Japan in 2011, several artists turned  their  practices  towards  the  subject  of  disaster  support.  Drawing on the philosophy of Bruno Latour, I argue that these artistic practices come  to articulate and  represent the multitude of concerns interwoven with disaster.  ...

  5. Influence of Consumer Demographics on the Demand for Locally Grown Ethnic Greens and Herbs Because of Food Miles Concerns: A Logit Model Analysis

    OpenAIRE

    Govindasamy, Ramu; Purduri, Venkata; Kelley, Kathleen; James E. Simon

    2012-01-01

    This project was supported by the Specialty Crop Research Initiative of the National Institute of Food and Agriculture, USDA, Grant # 2009-51181-06035. Trade in fresh fruits and vegetables has raised concerns about the distance food travels, food cost, freshness, and climate change associated with the transport. The term food mile refers to the distance or the number of miles that food travels from producer to consumer through its supply chain. Purchasing directly from local farmers may reduc...

  6. Exploring the binding mechanism of 5-hydroxy-3‧,4‧,7-trimethoxyflavone with bovine serum albumin: Spectroscopic and computational approach

    Science.gov (United States)

    Sudha, A.; Srinivasan, P.; Thamilarasan, V.; Sengottuvelan, N.

    2016-03-01

    The current study was carried out to investigate the binding mechanism of a potential flavonoid compound 5-hydroxy-3‧,4‧,7-trimethoxyflavone (HTMF) with bovine serum albumin (BSA) using ultraviolet-visible, fluorescence, circular dichroism (CD) spectral measurements along with molecular docking and molecular dynamics (MD) simulation. It was confirmed from fluorescence spectra that the intrinsic fluorescence of BSA was robustly quenched by HTMF through a static quenching mechanism. The number of binding sites (n) for HTMF binding on BSA was found to be about one. The thermodynamic parameters estimated from the van't Hoff plot specified that hydrophobic force was the predominant force in the HTMF-BSA complex and there also exist hydrogen bonds and electrostatic interactions. The effect of HTMF on the BSA conformation examined using CD studies revealed that there is a decrease in the helical content of BSA upon HTMF interaction. The results of molecular docking study shed light on the binding mode which exposed that HTMF bind within the hydrophobic pocket of the subdomain IIIA of BSA. The stability of HTMF-BSA complex with respect to free protein was analyzed from the molecular dynamic studies. The electronic structure analysis of HTMF was achieved by using density functional theory (DFT) calculations at B3LYP/6-31G** level to support its antioxidant role. The results of computational analysis are in good consistence with the experimental data and the present findings suggested that HTMF exhibits a good binding propensity to BSA protein which will be helpful for the drug design.

  7. Concerning ethical risk assessment

    International Nuclear Information System (INIS)

    After a fundamental consideration of the concept of responsibility and 'long-term responsibility' for late sequelae, the problems of an ehtical assessment of risks were illustrated: The concept of risk itself poses three problems - predicting the probability of occurrence, assessing the damage = subjective classification of the degree of damage, determining whether the advantages outweigh the risks. It is not possible to weigh the advantages and risks against each other without assessing the goals and the priorities which have been set. Here ethics is called for, because it concerns itself with the reasonableness of evaluative decisions. Its task is to enable us to become aware of and comprehend our system of values in all of its complexity in reference to real life. Ethics can only fulfill its task if it helps us to adopt an integral perspective, i.e. if it centers on the human being. 'One must assess all technical and economic innovations in terms of whether they are beneficial to the development of mankind on a long-term basis. They are only to be legitimized insofar as they prove themselves to be a means of liberating mankind and contributing to his sense of dignity and identity, as a means of bringing human beings together and encouraging them to care for one another, and as a means of protecting the natural basis of our existence. (orig./HSCH)

  8. Adolescent fertility: worldwide concerns.

    Science.gov (United States)

    Senderowitz, J; Paxman, J M

    1985-04-01

    There is growing concern over the adverse health, social, economic, and demographic effects of adolescent fertility. Morbidity and mortality rates ar significantly higher for teenage mothers and their infants, and early initiation of childbearing generally means truncated education, lower future family income, and larger completed family size. Adolescent fertility rates, which largely reflect marriage patterns, range from 4/1000 in Mauritania; in sub-Saharan Africa, virtually all rates are over 100. In most countries, adolescent fertility rates are declining due to rising age at marriage, increased educational and economic opportunities for young women, changes in social customs, increased use of contraception, and access to abortion. However, even if fertility rates were to decline dramatically among adolescent women in developing countries, their sheer numbers imply that their fertility will have a major impact on world population growth in the years ahead. The number of women in the world ages 15-19 years is expected to increase from 245 million in 1985 to over 320 million in the years 2020; 82% of these women live in developing countries. As a result of more and earlier premarital sexual activity, fostered by the lengthening gap between puberty and marriage, diminished parental and social controls, and increasing peer and media pressure to be sexually active, abortion and out-of-wedlock childbearing are increasing among teenagers in many developed and rapidly urbanizing developing countries. Laws and policies regarding sex education in the schools and access to family planning services by adolescents can either inhibit or support efforts to reduce adolescent fertility. Since contraceptive use is often sporadic and ineffective among adolescents, family planning services are crucial. Such programs should aim to reduce adolescents' dependence on abortion through preventive measures and increase awareness of the benefits of delayed sexual activity. Similarly, sex

  9. Biosimilars: Hope and concern.

    Science.gov (United States)

    Emmanouilides, Christos E; Karampola, Maria I; Beredima, Maria

    2016-08-01

    As patents of the first introduced biologic therapeutics in oncology have begun to expire, competing pharmaceutical companies are allowed to produce and market the same protein as the original agent. These products are called biosimilars. Upon patent expiration, biosimilars would hopefully be a cheaper alternative to the original agent and that is the main reason for their existence. Although the financial aspect is similar to generics, the complex nature of these products generates the need for a distinct regulatory environment. Biosimilars are produced by DNA technology in bacteria, plant cells, or animal cells, while generics are produced by chemical synthesis. Details in the process of synthesis, selection of the microorganism, protein extraction, purification and manufacturing, affect the precise nature of the end product. Monoclonal antibodies are large proteins with four polypeptide chains and interact variably with each other and with the environment. It is important for payors to realize that biosimilars are different from generics; therefore, they need to develop different set of rules for approving, registering, and dispensing biosimilars. Regulators ought to respect the physicians' request for non-interchangeability and facilitate in any possible way of traceability. Such regulations along with a rigorous pharmacovigilance program will satisfy the concerns for true equivalence in activity and long-term safety. This is the only way to accumulate over time reliable safety information for new biosimilars. In conclusion, the wish born by the medical community and the society for a more affordable health system triggers the emergence of biosimilars, which could meet that goal if properly regulated. PMID:26391898

  10. Producer’s Responsibility Concerning the Assurance and Statement of Quality for Foods with “Organic Image” based on the Model of a Romanian Company

    Directory of Open Access Journals (Sweden)

    Magdalena Bobe

    2014-02-01

    Full Text Available The responsibility of organizations to the consumer has now become a permanent concern, the principles of ethics in their activities result in attracting new customers and thus in their remaining within competition. The present study aims to highlight the importance of producers’ accountability in ensuring the quality of foodstuffs obtained through sustainable methods of production and to correctly and completely inform the consumers. The research follows the quality analysis of a product with an “organic image” addressed to the market/consumers, by testing the physicochemical and microbiological characteristics in the laboratory of the National Research and Development Institute for Food Bio- Resources in Bucharest, as well as comparing the obtained results with the values stated in the producer’s specifications; the main purpose is checking the conformity and establishing the validity of the published nutritional information and the statements regarding the product’s quality made on the printed label.

  11. Common menstrual concerns of adolescents

    OpenAIRE

    Sacks, Diane

    1998-01-01

    Symptoms associated with menstruation are among the most common concerns of adolescent women. However, the factual information that adolescent women need is not always available to them. Physicians can do much to correct the myths and misinformation that the teenager may have concerning her menstrual cycle. This paper addresses clinical office concerns about normal menstruation, dysmenorrhea, amenorrhea and dysfunctional uterine bleeding.

  12. Addressing Public Concerns about GMOs

    Science.gov (United States)

    The introduction of genetic engineering technology to agriculture has raised concerns in the public sector regarding the safety of applying this technology to the food supply. Concerns focus on two major issues: human/animal health and environmental risks. Such concerns have arisen in part because...

  13. Addressing Thermal Model Run Time Concerns of the Wide Field Infrared Survey Telescope using Astrophysics Focused Telescope Assets (WFIRST-AFTA)

    Science.gov (United States)

    Peabody, Hume; Guerrero, Sergio; Hawk, John; Rodriguez, Juan; McDonald, Carson; Jackson, Cliff

    2016-01-01

    The Wide Field Infrared Survey Telescope using Astrophysics Focused Telescope Assets (WFIRST-AFTA) utilizes an existing 2.4 m diameter Hubble sized telescope donated from elsewhere in the federal government for near-infrared sky surveys and Exoplanet searches to answer crucial questions about the universe and dark energy. The WFIRST design continues to increase in maturity, detail, and complexity with each design cycle leading to a Mission Concept Review and entrance to the Mission Formulation Phase. Each cycle has required a Structural-Thermal-Optical-Performance (STOP) analysis to ensure the design can meet the stringent pointing and stability requirements. As such, the models have also grown in size and complexity leading to increased model run time. This paper addresses efforts to reduce the run time while still maintaining sufficient accuracy for STOP analyses. A technique was developed to identify slews between observing orientations that were sufficiently different to warrant recalculation of the environmental fluxes to reduce the total number of radiation calculation points. The inclusion of a cryocooler fluid loop in the model also forced smaller time-steps than desired, which greatly increases the overall run time. The analysis of this fluid model required mitigation to drive the run time down by solving portions of the model at different time scales. Lastly, investigations were made into the impact of the removal of small radiation couplings on run time and accuracy. Use of these techniques allowed the models to produce meaningful results within reasonable run times to meet project schedule deadlines.

  14. SewageLCI 1.0 - A first generation inventory model for quantification of chemical emissions via sewage systems. Application on chemicals of concern

    DEFF Research Database (Denmark)

    Gallice, Aurélie; Birkved, Morten; Kech, Sébastien

    Lack of inventory data on chemical emissions often forces life cycle assessors to rely on crude emissions estimates (e.g. 100 % of the applied chemical mass is assumed emitted) or in the worst case to omit chemical emissions due to lack of emission data. The inventory model SewageLCI 1.0, provides...... a mean for assessors to obtain fractions of chemicals emitted to the environment via waste water collection and treatment systems. SewageLCI 1.0 is based on existing models capable of estimating chemical degradation in waste water collection and treatment systems and also on national European...

  15. A spatio-temporal simulation model of the response of solid tumours to radiotherapy in vivo: parametric validation concerning oxygen enhancement ratio and cell cycle duration

    International Nuclear Information System (INIS)

    Advanced bio-simulation methods are expected to substantially improve radiotherapy treatment planning. To this end a novel spatio-temporal patient-specific simulation model of the in vivo response of malignant tumours to radiotherapy schemes has been recently developed by our group. This paper discusses recent improvements to the model: an optimized algorithm leading to conformal shrinkage of the tumour as a response to radiotherapy, the introduction of the oxygen enhancement ratio (OER), a realistic initial cell phase distribution and finally an advanced imaging-based algorithm simulating the neovascularization field. A parametric study of the influence of the cell cycle duration Tc, OER, OERβ for the beta LQ parameter on tumour growth, shrinkage and response to irradiation under two different fractionation schemes has been made. The model has been applied to two glioblastoma multiforme (GBM) cases, one with wild type (wt) and another one with mutated (mt) p53 gene. Furthermore, the model has been applied to a hypothetical GBM tumour with α and β values corresponding to those of generic radiosensitive tumours. According to the model predictions, a whole tumour with shorter Tc tends to repopulate faster, as is to be expected. Furthermore, a higher OER value for the dormant cells leads to a more radioresistant whole tumour. A small variation of the OERβ value does not seem to play a major role in the tumour response. Accelerated fractionation proved to be superior to the standard scheme for the whole range of the OER values considered. Finally, the tumour with mt p53 was shown to be more radioresistant compared to the tumour with wt p53. Although all simulation predictions agree at least qualitatively with the clinical experience and literature, a long-term clinical adaptation and quantitative validation procedure is in progress

  16. Some observations concerning blade-element-momentum (BEM) methods and vortex wake methods, including numerical experiments with a simple vortex model

    Energy Technology Data Exchange (ETDEWEB)

    Snel, H. [Netherlands Energy Research Foundation ECN, Renewable Energy, Wind Energy (Netherlands)

    1997-08-01

    Recently the Blade Element Momentum (BEM) method has been made more versatile. Inclusion of rotational effects on time averaged profile coefficients have improved its achievements for performance calculations in stalled flow. Time dependence as a result of turbulent inflow, pitching actions and yawed operation is now treated more correctly (although more improvement is needed) than before. It is of interest to note that adaptations in modelling of unsteady or periodic induction stem from qualitative and quantitative insights obtained from free vortex models. Free vortex methods and further into the future Navier Stokes (NS) calculations, together with wind tunnel and field experiments, can be very useful in enhancing the potential of BEM for aero-elastic response calculations. It must be kept in mind however that extreme caution must be used with free vortex methods, as will be discussed in the following chapters. A discussion of the shortcomings and the strength of BEM and of vortex wake models is given. Some ideas are presented on how BEM might be improved without too much loss of efficiency. (EG)

  17. Model for the accumulation of solar wind radiation damage effects in lunar dust grains, based on recent results concerning implantation and erosion effects

    Energy Technology Data Exchange (ETDEWEB)

    Borg, J.; Bibring, J.P.; Cowsik, G.; Langevin, Y.; Maurette, M.

    1983-02-15

    In this paper we present our most recent results on ion implantation and erosion effects, intended to reproduce the superficial amorphous layers of radiation damage observed with a high voltage electron microscope on ..mu..m-sized grains extracted from the lunar regolith and which result from the exposure of the grains to the solar wind. We next outline theoretical computations which yield the thickness distribution of such amorphous layers as a function of the exposure time of the grains at the surface of the moon, the He/H ratio, and the speed distribution in the solar wind. From this model, the position of the peak in the solar wind speed distribution is the major parameter controlling the thickness of the amorphous layer.

  18. Concerns Girls Have about Puberty

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... Content Article Body Girls have pubertal concerns and worries, too, including: Breast Development Some girls also have anxieties about breast development. ...

  19. Issues concerning the light-duty diesel

    Energy Technology Data Exchange (ETDEWEB)

    Clusen, Ruth C.

    1979-09-01

    The current reasons for concern about the diesel engine for light-duty vehicles are explained, and an overview of the major issues impacting upon future diesel-related policy considerations is presented. Light-duty diesels are of immediate concern because proposed environmental legislation could impact upon their market future as early as model year 1981. The environmental issues affecting these vehicles also have implications for other categories of diesels (heavy-duty mobile and stationary application). Part I presents background and overview information on the reasons for the diesel's emergence as a major concern in the regulatory area and Part II summarizes the issues surrounding the diesel in three major areas: protecting health and the environment; fuel conservation; and broad economic and programmaic trade-offs arising from the previous two areas.

  20. Globalization and new policy concerns

    DEFF Research Database (Denmark)

    Daugbjerg, Carsten; Swinbank, Alan

    2015-01-01

    The transfer of some decision-making authority from the domestic to the supranational arena as a result of the establishment of the World Trade Organization (WTO) in 1995 potentially changed domestic policy dynamics. The WTO agreements reflect the trade policy concerns addressed in the Uruguay...... Round in the late 1980s and early 1990s. This article applies and adapts historical institutionalism to explain how international organizations may constrain and facilitate certain domestic policy options. It demonstrates that, while the WTO legal framework has become more receptive of environmental...... sustainability concerns, the social sustainability concerns that were increasingly entering the debate over biofuel policies were not easily accommodated, and this was seen as a constraint on the content of the European Union's (EU) policy adopted in 2009. Only the environmental dimension of a broader concept...

  1. Legal issues concerning heat pumps

    Energy Technology Data Exchange (ETDEWEB)

    Gersemann, D.

    Heat pumps are considered suitable to contribute to an improvement of the total energy balance. As a rule, they are divided into the following categories of utilizable auxiliary energies: ground water, surface waters, soil, absorbers, air. They are also distinguished according to driving systems: electric, gas, or Diesel heat pumps. Considering forecasts concerning the utilization potential of heat pumps it seems easy to see that the legal assessment of heat pumps shall obtain considerable practical importance for the authorities as well as for private managers. The article gives a survey of the most important legal issues concerning heat pumps.

  2. Parental concerns about complementary feeding

    DEFF Research Database (Denmark)

    Nielsen, Annemette; Michaelsen, Kim F.; Holm, Lotte

    2013-01-01

    Background/objectives:To investigate and analyze differences in parental concerns during earlier and later phases of complementary feeding.Subject/methods:Eight focus group interviews were conducted with 45 mothers of children aged 7 or 13 months. Deductive and inductive coding procedures were...

  3. Licensing concerns in SSI methodology

    International Nuclear Information System (INIS)

    This paper addresses some of the more immediate Nuclear Regulatory concerns in the controversial subject of soil-structure interactions in US nuclear power plant design practice. Topics covered include: choice of solution method, the need for sophisticated analyses, frequency variation, ground motion reduction with depth, and buried structures. Recommendations under consideration by NRC staff are presented

  4. AIDS: Dynamics and Rehabilitation Concerns.

    Science.gov (United States)

    Wong, Henry; And Others

    1988-01-01

    The epidemic of Acquired Immune Deficiency Syndrome (AIDS) confronts the rehabilitation professional with a number of concerns. This paper reviews literature on the diagnosis, epidemiological factors, psychosocial elements, medical intervention of AIDS, and rehabilitation issues involved in serving AIDS patients. (JDD)

  5. Career Concern and Tax Preparer Fraud

    OpenAIRE

    Chao Yang; Liansheng Wu; Xianhui Bo

    2010-01-01

    This paper focuses on the effects of career concern on fraud among tax return preparers. A two-stage model is built to ascertain whether the propensity of tax preparers to cooperate with taxpayers in underpaying tax can be decreased if the revealed fraud behavior increases the probability of being audited by the tax agency in the following period. After solving the unique SPNE, this effect is shown to exist.

  6. Normal Functions Concerning Shared Values

    Institute of Scientific and Technical Information of China (English)

    WANG XIAO-JING

    2009-01-01

    In this paper we discuss normal functions concerning shared values. We obtain the follow result. Let F be a family of meromorphic functions in the unit disc △, and a be a nonzero finite complex number. If for any f ∈ F, the zeros of f are of multiplicity, f and f' share a, then there exists a positive number M such that for any f ∈ F, (1 -|z|~2)(|f'(z)|)/(1+|f(z)|~2)≤ M.

  7. Career Concerns of Banking Analysts

    OpenAIRE

    Horton, Joanne; Serafeim, Georgios; Wu, Shan

    2015-01-01

    We study how career concerns influence banking analysts’ forecasts and how their forecasting behavior benefits both them and bank managers. We show that banking analysts issue early in the year relatively more optimistic and later in the year more pessimistic forecasts for banks that could be their future employers. This pattern is not observed when the same analysts forecast earnings of companies that are not likely to be their future employers. Moreover, we use the Global Settlement as an e...

  8. Effciency Concern under Asymmetric Information

    OpenAIRE

    Winschel, Evguenia; Zahn, Philipp

    2012-01-01

    Experimental evidence from simple distribution games supports the view that some individuals have a concern for the effciency of allocations. This motive could be important for the implementation of economic policy proposals. In a typical lab experiment, however, individuals have much more information available than outside the lab. We conduct a lab experiment to test whether asymmetric information influences prosocial behavior in a simple non-strategic interaction. In our setting, a dictator...

  9. Secondary Teachers' Concerns in Adopting Learning Management Systems: A U.S. Perspective

    Science.gov (United States)

    Lochner, Bianca; Conrad, Rita-Marie; Graham, Edward

    2015-01-01

    This study examined the concerns of U.S. secondary teachers regarding the adoption of learning management systems (LMSs) utilizing the concerns-based adoption model (CBAM). The stages of concern questionnaire used enabled the strength of teacher concerns to be measured for seven distinct stages of concerns: awareness, informational, personal,…

  10. Researches with the 'Fertexpert' model concerning the relationships between the efficiency indexes of the fertilizers usage in optimal economic rates and the agrochemical indexes of the soil and expected yields

    International Nuclear Information System (INIS)

    The 'Fertexpert' model allows undertaking researches concerning the variation of efficiency indexes for fertilizers usage in the case of many crops depending on the content of available soil nutrients (the values of soil agrochemical indexes - IA) and on the expected yield, Rs, when fertilization are applied in optimal economic rates, DOE. The physical efficiency indexes calculated and researched are the following: the total physical yield increase, SFR (kg/ha), the specific average yield increase, SSp (kg/kg N, P2O5 or K2O), the specific consumption of active substance (a.s.) from fertilizer, CSp (kg a.s./1 kg average yield increase). The economic efficiency indexes computed are: the total profit, in monetary units/ha, the specific profit, in monetary units/l monetary unit spent with fertilization, PSp, and in monetary units/kg a.s., PSpsa. The model also allows the study of DOE variation depending on Rs and IA. Starting from the made calculations, there can be drown up specific graphics that can then be used in practice and for research purposes to. Refs. 6 (author)

  11. SOME QUESTIONS CONCERNING PSYCHOANALYTICAL FORMATION

    Directory of Open Access Journals (Sweden)

    Orlando Soeiro Cruxên

    2009-12-01

    Full Text Available The psychoanalytical formation is a question without a definitive answer. The development of its study requests treatment of the evolution of the clinical theory. This work begins with a distinction between analytical and academic formation. It includes Jacques Lacan’s approach concerning the question of psychoanalytical formation. It discusses the relationship between the named intentional and extensional psychoanalysis. This article resumes some theoretical aspects of a post-doctoral investigation developed in the clinical-school of Psychology (Universidade Federal do Ceará e SAP ( Pontifícia Universidade Católica do Rio Grande doSul.

  12. Sillamaee - a common Baltic concern

    International Nuclear Information System (INIS)

    The problems of uranium mining and milling are related to the huge amount of waste containing radioactive as well as chemical pollutants. Tailings can be satisfactorly protected so that the environmental impact is minor in the short term. The methods to reduce the risks are many. The actual releases today in the Sillamaee region of the Baltic Sea from the tailings pond are relatively small and should not give rise to concern. However, the situation is unstable, which is why efforts to find remediation methods are justified

  13. α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF.

    Science.gov (United States)

    Guo, Ming; Wang, Xiaomeng; Lu, Xiaowang; Wang, Hongzheng; Brodelius, Peter E

    2016-01-01

    In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction method for industrial application was explored. A high yield of α-mangostin (5.2%) was obtained by extraction from dried mangosteen pericarps with subsequent purification on macroporous resin HPD-400. The chemical structure of α-mangostin was verified mass spectrometry (MS), nuclear magnetic resonance (1H NMR and 13C NMR), infrared spectroscopy (IR) and UV-Vis spectroscopy. The purity of the obtained α-mangostin was 95.6% as determined by HPLC analysis. The binding of native α-mangostin to human serum albumin (HSA) or transferrin (TRF) was explored by combining spectral experiments with molecular modeling. The results showed that α-mangostin binds to HSA or TRF as static complexes but the binding affinities were different in different systems. The binding constants and thermodynamic parameters were measured by fluorescence spectroscopy and absorbance spectra. The association constant of HSA or TRF binding to α-mangostin is 6.4832×105 L/mol and 1.4652×105 L/mol at 298 K and 7.8619×105 L/mol and 1.1582×105 L/mol at 310 K, respectively. The binding distance, the energy transfer efficiency between α-mangostin and HSA or TRF were also obtained by virtue of the Förster theory of non-radiation energy transfer. The effect of α-mangostin on the HSA or TRF conformation was analyzed by synchronous spectrometry and fluorescence polarization studies. Molecular docking results reveal that the main interaction between α-mangostin and HSA is hydrophobic interactions, while the main interaction between α-mangostin and TRF is hydrogen bonding and Van der Waals forces. These results are consistent with spectral results. PMID:27584012

  14. Concerned Journals, Editors And ICMJE

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    Full Text Available This section will detail some important initiatives taken by journal editors in writing about industry influence on academia in particular and medicine in general. It will also look into the Revised Guidelines of the ICMJE vis-à-vis issues related to industry-sponsored research. Journals And Editors In the last chapter, we saw how conflict of interest related to individuals and institutions are discussed and resolved by AAMC. Conflict of interest because of industry's increasing clout has also engaged the attention of editors of important journals and some significant editorials in this connection are worth a close study by all concerned researchers and institutions, for they reflect reasoned responses to disturbing developments. The titles themselves reflect their concern:Is academic medicine for sale? (Angell, N Engl J Med , 2000Angell asks a piquant question of academic medical institutions:'Academic medical institutions are themselves growing increasingly beholden to industry. How can they justify rigorous conflict-of-interest policies for individual researchers when their own ties are so extensive?' Answering as to why Academia-industry connect flourishes, she says: 'Some academic institutions have entered into partnerships with drug companies to set up research centers and teaching programs in which students and faculty members essentially carry out industry research. Both sides see great benefit in this arrangement. For financially struggling medical centers, it means cash. For the companies that make the drugs and devices, it means access to research talent, as well as affiliation with a prestigious "brand." Asking herself the question: 'Why shouldn't clinical researchers have close ties to industry?' she answers it decisively tilts academia's inclinations to serve industry interests in various ways, rather than that of biomedical advance:'One obvious concern is that these ties will bias research, both the kind of work that is done and

  15. The Mighty Morphin Power Rangers: Teachers Voice Concern.

    Science.gov (United States)

    Levin, Diane E.; Carlsson-Paige, Nancy

    1995-01-01

    Presents the results of a study exploring teachers' concerns and observations of how the "Power Rangers" television series affects children in their classrooms. Teachers' concerns focus on violence, aggressive play, confusion about fantasy and reality, obsessive involvement with the Power Rangers, and use of them as role models for social…

  16. Students' Concern about Indebtedness: A Rank Based Social Norms Account

    Science.gov (United States)

    Aldrovandi, Silvio; Wood, Alex M.; Maltby, John; Brown, Gordon D. A.

    2015-01-01

    This paper describes a new model of students' concern about indebtedness within a rank-based social norms framework. Study 1 found that students hold highly variable beliefs about how much other students will owe at the end of their degree. Students' concern about their own anticipated debt--and their intention of taking on a part-time job during…

  17. Career concerns incentives: An experimental test

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht; Raab, Philippe

    Holmström's (1982/99) career concerns model has become a workhorse for analyzing agency issues in many fields. The underlying signal jamming argument requires players to use information in a Bayesian way, which is difficult to directly test with field data: typically little is known about the...... information that individuals base their decisions on. Our laboratory experiment provides prima facie evidence: i) the signal jamming mechanism successfully creates incentives on the labor supply side; ii) decision errors take time to decrease; iii) while subjects' average beliefs are remarkably consistent...

  18. Career concerns incentives: An experimental test

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht; Raab, Philippe

    2009-01-01

    Holmström's (1982/99) career concerns model has become a workhorse for analyzing agency issues in many elds. The underlying signal jamming argument requires players to use information in a Bayesian way, which is difficult to directly test with eld data: typically little is known about the...... information that individuals base their decisions on. Our laboratory experiment provides prima facie evidence: i) the signal jamming mechanism successfully creates incentives on the labor supply side; ii) decision errors take time to decrease; iii) while subjects’ average beliefs are remarkably consistent...

  19. Recent developments concerning the fusion

    International Nuclear Information System (INIS)

    Organized the 9 march 2000 by the SFEN, this meeting on the european program concerning the fusion, showed the utility of the exploitation and the enhancement of the actual technology (JET, Tore Supra, ASDEX) and the importance of the Europe engagement in the ITER program. The physical stakes for the magnetic fusion have been developed with a presentation of the progresses in the knowledge of the stability limits. A paper on the inertial fusion was based on the LMJ (Laser MegaJoule) project. The two blanket concepts chosen in the scope of the european program on the tritium blankets, have been discussed. These concepts will be validated by irradiation tests in the ITER-FEAT and adapted for a future reactor. (A.L.B.)

  20. HEPA filter concerns - an overview

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) recently initiated a complete review of the DOE High Efficiency Particulate Air (HEPA) Filter Program to identify areas for improvement. Although this process is currently ongoing, various issues and problems have already been identified for action that not only impacts the DOE HEPA filter program, but potentially the national and international air cleaning community as well. This paper briefly reviews a few of those concerns that may be of interest, and discusses actions initiated by the DOE to address the associated issues and problems. Issues discussed include: guidance standards, in-place testing, specifications, Test Facilities, portable units, vacuum cleaners, substitute aerosols, filter efficiencies, aging/shelf life/service life, fire suppression, handbook, Quality Products List (QPL), QA testing, and evaluations

  1. Alternative energy and environmental concerns

    International Nuclear Information System (INIS)

    The New Brunswick Market Design Committee will address environmental concerns within the context of the new energy policy and market rules for the newly restructured electric power industry. The new rules that come with power restructuring will in some ways facilitate environmental protection but they can also complicate it. With open access markets, it will be possible to coordinate evolving energy frameworks with current environmental objectives. Restructuring provides an opportunity to create incentives and guidelines to operate in an environmentally sustainable manner, as suggested in the New Brunswick Energy Policy, White Paper which outlines green pricing, the development of a provincial Climate Change Action Plan, and promotion of alternative energy. The Market Design Committee examined the environmental concerns listed within the White Paper that pertain to the generation and transmission of electricity. These include the integration of energy and environmental policy. Other issues addressed in this report were trans-boundary and global air emissions, the development of a provincial climate change action plan, and a federal-provincial climate change framework agreement. New Brunswick will encourage the development of pilot studies that demonstrate the benefits of renewable and alternative technologies and that help promote the market to manufacture, sell and maintain renewable and alternative technologies in small-scale on-site power generation. This report also discussed the 4 key air pollutants for which specific treatment has been defined, including sulphur dioxide, nitrogen oxides, mercury and carbon dioxide. Recommendations for reducing these emissions include the use of renewable energy sources, the use of lower carbon fuels, increased efficiency of power transmission/generation/distribution systems, reducing power demand by the industrial sector, and promoting energy efficient building codes. 34 refs., 1 tab

  2. Some coolness concerning global warming

    Science.gov (United States)

    Lindzen, Richard S.

    1990-01-01

    The greenhouse effect hypothesis is discussed. The effects of increasing CO2 levels in the atmosphere on global temperature changes are analyzed. The problems with models currently used to predict climatic changes are examined.

  3. Mobile phones and health concerns

    International Nuclear Information System (INIS)

    As Mobile Cellular phone ownership grows throughout the developed as well as the developing world, concerns about the health risks due to radio frequency emissions from the mobile phone base stations and due to usage of mobile handsets are slowly growing. This article has a look at the concepts used in the mobile phone technology, the power outputs from base stations and mobile handsets, the quantities Specific Energy Absorption Rate (SAR) and power density as a means to assess the effects on biological tissue. The precautionary approach to manage the health risks from mobile phones by specifying exposure guidelines is explored. Having surveyed the relevant epidemiological surveys and finding them inconclusive, NRPB, United Kingdom's national regulatory body has issued exposure guidelines based on the potential of RF radiation to cause illness or injury through heating of body tissues. USA's Federal Communications Commission (FCC) limits are also listed for comparison. ICNIRP has issued two-tier guidelines, differentiating between occupational and public exposure. The public exposure limits are kept at one-fifth of the occupational exposure limits. The evidence till date, suggests that exposure to RF radiation below NRPB and ICNIRP limits do not cause adverse effects to the general population. However, the gaps in our knowledge warrant a precautionary approach. (author)

  4. Ombuds’ corner: Confidentiality concerning boards

    CERN Multimedia

    Vincent Vuillemin

    2011-01-01

    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Phil* was a candidate for a position in a different group from the one he had been working for. After his board had taken place, Phil asked for an appointment with the Ombuds. In his opinion, the interview went reasonably well. However Phil had some concerns as he had heard that there was no point in him applying as another candidate will get the position. He had decided to apply anyway, encouraged by other people, with the hope that he would get a good rating that could help him get a position in the future, if he didn't get present one. During the interview he was asked some questions that could only have been answered by candidates with  experience related ...

  5. Food irradiation: benefits and concerns

    International Nuclear Information System (INIS)

    The benefits and concerns about treating foods with ionizing radiation are reviewed. Radioactivity cannot be induced in foods by treatment with gamma rays from 137Cs or 60Co, X-ray sources of 5 MeV or lower energy, or electrons of 10 MeV or lower energy. The evidence supports the safety and efficacy of using ionizing radiation for insect disinfestation of grains; dried spices, vegetables and fruits; and fresh fruit. Species and dose dependent phytotoxic and vitamin changes may occur in some fruits at greater doses than currently approved by the U.S. Food and Drug Administration. Irradiation can inactivate protozoan or helminth parasites and significantly decrease the probability of viable food-borne bacterial pathogens in fish, poultry, and red meats. The titers of amino acids, fatty acids, and vitamins of chicken meat sterilized by thermal, electron-beam, or gamma radiation are presented. On the whole, the data support the safely and efficacy of the process

  6. X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism

    Science.gov (United States)

    2016-01-01

    Ruthenium(III) complexes are promising candidates for anticancer drugs, especially the clinically studied indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its analogue sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (NKP-1339). Several studies have emphasized the likely role of human serum proteins in the transportation and accumulation of ruthenium(III) complexes in tumors. Therefore, the interaction between KP1019 and human serum albumin was investigated by means of X-ray crystallography and inductively coupled plasma mass spectrometry (ICP-MS). The structural data unambiguously reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located within well-known hydrophobic binding pockets of albumin. The ruthenium centers are octahedrally coordinated by solvent molecules revealing the dissociation of both indazole ligands from the ruthenium-based drug. However, a binding mechanism is proposed indicating the importance of the indazole ligands for binding site recognition and thus their indispensable role for the binding of KP1019. PMID:27196130

  7. X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism.

    Science.gov (United States)

    Bijelic, Aleksandar; Theiner, Sarah; Keppler, Bernhard K; Rompel, Annette

    2016-06-23

    Ruthenium(III) complexes are promising candidates for anticancer drugs, especially the clinically studied indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its analogue sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (NKP-1339). Several studies have emphasized the likely role of human serum proteins in the transportation and accumulation of ruthenium(III) complexes in tumors. Therefore, the interaction between KP1019 and human serum albumin was investigated by means of X-ray crystallography and inductively coupled plasma mass spectrometry (ICP-MS). The structural data unambiguously reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located within well-known hydrophobic binding pockets of albumin. The ruthenium centers are octahedrally coordinated by solvent molecules revealing the dissociation of both indazole ligands from the ruthenium-based drug. However, a binding mechanism is proposed indicating the importance of the indazole ligands for binding site recognition and thus their indispensable role for the binding of KP1019. PMID:27196130

  8. Lean Transformation of Multinational Concerns

    OpenAIRE

    Matthiesen, Rikke Vestergaard; Johansen, John

    2008-01-01

    Abstract. Competitive pressure demands that companies constantly strive to catch up to world class manufacturing performance and practice. Continuous change is a mode of competition for many companies [1]. This is a departure from the punctuated equilibrium model of change in which change is event triggered. This paper reports on exploratory studies from a multinational company adopting centrally managed pilot projects as a transformation mechanism for continuous change towards a lean busines...

  9. Issues concerning global warming today

    Institute of Scientific and Technical Information of China (English)

    Zhenqiu REN

    2008-01-01

    The global weather of today is growing significantly warmer; this is an indisputable fact.However,the scientific community has not yet reached consensus on the causes of global warming and its possible consequences.This paper introduces the causes of global warming and summarizes its results,which both involve a series of huge and complex system issues.Our top priority is to pinpoint the main reason and the interrelated links between causative factors by adopting a macro-approach,or comprehensive comparison analysis.Its physical mechanism was then determined and its digital model established after quantitative study.

  10. Sex and Prevention Concerns for Positive People

    Science.gov (United States)

    ... with any comments or concerns. February 17, 2011 Sex and prevention concerns for positive people Facebook Twitter ... partner, and vice versa. The reality of safer sex You put yourself at risk for infections through ...

  11. Identifying Concerns of Parents of Young Children

    OpenAIRE

    Mackenzie, Sandra; Evers, Susan

    1986-01-01

    A survey was conducted to ascertain parenting concerns and willingness to participate in parenting groups as a means of addressing concerns. Questionnaires were sent to 121 families with a child aged three years or under. Mothers and fathers were asked to complete separate questionnaires. Analysis of the 85 sets of questionnaires returned indicates that more mothers (51.8%) than fathers (24.9%) had at least five parental concerns. The top five concerns of mothers were “discipline”, “childhood...

  12. Treatment Concerns and Functional Impairment in Pediatric Anxiety.

    Science.gov (United States)

    Wu, Monica S; Salloum, Alison; Lewin, Adam B; Selles, Robert R; McBride, Nicole M; Crawford, Erika A; Storch, Eric A

    2016-08-01

    Although there are efficacious, evidence-based treatments for anxiety disorders, youth often experience delays in seeking therapy. Myriad reasons may contribute to this lag in treatment initiation, with some youth possessing concerns about therapy. Treatment concerns are broadly characterized by worries/ambivalence about seeking treatment, including concerns about the negative reactions, consequences, and inconvenience of treatment. As no studies exist for youth with anxiety disorders, this study examined the phenomenology of treatment concerns in 119 treatment-seeking, anxious youth and utilized a structural equation model to examine the relationship between child anxiety, depressive symptoms, treatment concerns, and anxiety-related functional impairment. Over 90 % of the children positively endorsed some type of treatment-related fear, with the most frequently expressed concern being that therapy would take too much time (50.4 %). Based on the model, both child anxiety and depressive symptoms predicted functional impairment, and treatment concerns mediated the relationship between child anxiety and functional impairment. PMID:26438217

  13. Requirements concerning integrated event analysis

    International Nuclear Information System (INIS)

    The safe operation of nuclear plants is not only guaranteed by technical systems, but is also influenced to a large extent by human input. The interaction between human action, including the administrative and organisational functions, and the operation, maintenance and monitoring of a plant are of particular importance here. Consequently, incidents and events occurring in nuclear power plants need to be systematically investigated, not only to reconstruct the sequence of events, but also to determine the factors that triggered the event in the first place and then encouraged its development. The aim is to make a structured causal analysis to facilitate an objective search for the root causes and hidden deficiencies in the interaction between technical processes, human action and administrative/organisational aspects. The evaluation of events reported by other plants to ascertain transferability to your own plant is also very important. Incorporating the information obtained from this evaluation of the experience of comparable plants and equipment in your own plant management has a positive effect on the safe operation and availability of the plant. For example, additions are made to the operating instructions, technical modifications are incorporated in the plant and measures are taken to expand and maintain expertise in order to be able to take effective precautionary measures that also prevent a repetition of incidents and events at other plants from occurring at your own plant. The principal aim of safe power plant operation is achieved if the results of basis causal analyses on the basis of recognised evaluation models are integrated in power plant organisation units as experience feedback in order to involve and increase the awareness of all employees. (author)

  14. Moral considerations concerning income inequality

    Directory of Open Access Journals (Sweden)

    Jurjen P. de Vries

    2015-03-01

    Full Text Available The income inequality evident today has reached ethically unwarranted levels. In the Old and New Testament the Bible teaches us that disparity in wealth ought to meet the norms of justice and equity. Differences in income must be proportional to differences in the workers’performance and the responsibilities they assume. Employers and trade unions have the duty to ensure that these boundaries are respected. The government’s obligation is to take measures against the abuse of power monopolies, but it does not have to pursue income equality as such. Finally, where greed still rules society, Christians have the task to model a different life.In die hedendaagse samelewing kan aansienlike inkomsteverskille nie eties verantwoordword nie. In sowel die Ou as Nuwe Testament leer die Bybel ons dat verskille in inkomste aan die norm van regverdigheid en billikheid moet voldoen. Inkomsteverskille moet in ’n sinvolle verhouding tot die verskil in prestasie en verantwoordelikheid staan. Werkgewers en vakbonde moet in hierdie opsig die nodige grense in stand hou. Die owerheid kan maatreëls instel teen die wanpraktyke van magsmonopolieë, maar nie teen inkomste-ongelykhede as sulks nie. Wanneer hebsug die botoon in ’n samelewing voer, is dit die taak van Christene om’n eie lewenstyl te handhaaf.In de hedendaagse maatschappij zijn de inkomensverschillen groter dan ethisch verantwoord is. Het Oude en Nieuwe Testament van de Bijbel leren dat financiële verhoudingen moeten voldoen aan de normen van rechtvaardigheid en billijkheid. Inkomensverschillen moeten in redelijke verhouding staan tot het verschil in prestatie en verantwoordelijkheid. Werkgevers en vakorganisaties moeten hier de verantwoorde grenzen bewaken. De overheid neemt maatregelen tegen misbruik van machtsmonopolies ten eigen bate, maar voor haar is nivellering niet een doel op zich. En als in de maatschappij de hebzucht nog de boventoon voert, is het de taak van christenen hier een eigen

  15. Identity-driven differences in stakeholder concerns about hunting wolves.

    Science.gov (United States)

    Lute, Michelle L; Bump, Adam; Gore, Meredith L

    2014-01-01

    Whereas past wolf management in the United States was restricted to recovery, managers must now contend with publicly contentious post-recovery issues including regulated hunting seasons. Understanding stakeholder concerns associated with hunting can inform stakeholder engagement, communication, and policy development and evaluation. Social identity theory (SIT) has been used to understand how groups interact, why they conflict, and how collaboration may be achieved. Applying SIT to stakeholder conflicts about wolf hunting may help delineate groups according to their concern about, support for or opposition to the policy choice of hunting wolves. Our objective was to assess concerns about hunting as a tool to resolve conflict in Michigan, using SIT as a framework. We used a mixed-modal sampling approach (e.g., paper, Internet) with wolf hunting-related public meeting participants in March 2013. Survey questions focused on 12 concerns previously identified as associated with hunting as a management tool to resolve conflict. Respondents (n  =  666) cared greatly about wolves but were divided over hunting wolves. Wolf conflicts, use of science in policy decisions, and maintaining a wolf population were the highest ranked concerns. Principle components analysis reduced concerns into three factors that explained 50.7% of total variance; concerns crystallized over justifications for hunting. General linear models revealed a lack of geographic influence on care, fear and support for hunting related to wolves. These findings challenge assumptions about regional differences and suggest a strong role for social identity in driving dichotomized public perceptions in wildlife management. PMID:25464276

  16. WORLDWIDE AND EUROPEAN POLITICS CONCERNING THECLIMATE CHANGES

    OpenAIRE

    Maria Criveanu, univ.; Baluna Radu,

    2009-01-01

    One of the major concerns of our century is represented by the climate changes, a reason for which immediate and correct measures should be taken for an efficient approach of this problem, concerning costs and respecting the principle of prudence. Studies made by experts in this field concerning the climate changes have shown that during the past years there have been recorded increases of global medium temperatures of water and ocean, an extensive melting of snow and ice, together with a glo...

  17. Relative Income Concerns and the Rise in Married Women's Employment

    OpenAIRE

    David Neumark; Andrew Postlewaite

    1995-01-01

    We ask whether women's decisions to be in the labor force may be affected by the decisions of other women in ways not captured by standard models. We develop a model that augments the simple neoclassical framework by introducing relative income concerns into women's (or families') utility functions. In this model, the entry of some women into paid employment can spur the entry of other women, independently of wage and income effects. This mechanism may help to explain why, over some periods, ...

  18. Public concerns and alternative nuclear power systems

    International Nuclear Information System (INIS)

    The basic task undertaken in this study was to assess the relative public acceptability of three general types of nuclear power systems as alternatives to the existing Light Water Reactor (LWR) system. Concerns registered toward nuclear power constituted the basic data for this assessment. The primary measure adopted for determining the significance of concerns was the degree of difficulty posed by the concern to the nuclear power decisional structure in the establishment and maintenance of norms to control risks or to advance intended energy objectives. Alleviations or exacerbations of concern resulting from particular attributes of alternative systems were measured from an LWR baseline

  19. Concerns about the implantable cardioverter defibrillator

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; van Domburg, Ron T; Theuns, Dominic A M J;

    2005-01-01

    Patients with an implantable cardioverter defibrillator (ICD) are at increased risk of anxiety disorders. In turn, anxiety has been identified as a precipitant of ventricular arrhythmias. Anxiety may in part be attributed to concerns about the ICD firing, but the relationship between ICD concerns...

  20. Composing Crosscutting Concerns Using Composition Filters

    NARCIS (Netherlands)

    Bergmans, Lodewijk; Aksit, Mehmet

    2001-01-01

    It has been demonstrated that certain design concerns, such as access control, synchronization, and object interactions cannot be expressed in current OO languages as a separate software module [4, 7]. These so-called crosscutting concerns generally result in implementations scattered over multiple

  1. Liberation Linguistics and the Quirk Concern.

    Science.gov (United States)

    Kachru, Braj B.

    This paper addresses the concerns of Sir Randolph Quirk, former President of the British Academy and founder of the Survey of English Usage, regarding current paradigms used for describing various issues related to the diffusion of English in the global context. The historical context for these concerns is provided, a discussion of these concerns…

  2. General experiments concerning particle-matter interactions

    International Nuclear Information System (INIS)

    The author gathers in this document several papers he has already published in order to shed light on different aspects concerning ion-crystal interactions. This document is divided into 3 chapters. In the first chapter the author presents results obtained from experiments dedicated to charge exchanges and energy released by heavy ions in channeling conditions. Different processes involved in ion-electron interactions are considered: The tri-electronic recombination, the electron capture through nuclear excitation (NEEC), resonant transfer and excitation (RTE), resonant transfer and double excitation (RTDE) and electron impact ionization (EII). The second chapter deals with the measurement of nuclear fission times through crystal blocking experiments. The crystal blocking technique allows the measurement in a model-independent way of the recoil distance covered by the excited nucleus during the whole fission process (starting from the initial collision and ending at the scission point). The last chapter is dedicated to the photon impact ionization through the conversion of a high-energy photon into an electron-positron pair

  3. Patient concerns regarding chronic hepatitis C infections.

    Science.gov (United States)

    Minuk, G Y; Gutkin, A; Wong, S G; Kaita, K D E

    2005-01-01

    Counselling of patients with chronic hepatitis C infections is often limited to discussions regarding how the virus is transmitted and what can be done to decrease the risk of transmission to others. The purpose of the present study was to document the principal concerns of newly diagnosed and follow-up patients with chronic hepatitis C, and thereby enhance counselling strategies and content. Seventy newly diagnosed and 115 follow-up patients with chronic hepatitis C virus (HCV) infection were initially asked in an open-ended manner (volunteered concerns) and then to prioritize from a prepared list of seven potential concerns (prioritized concerns), to identify those concerns that were of utmost importance to them. The most common volunteered concerns of newly diagnosed patients in decreasing order were: disease progression (27%), premature death (19%), infecting family members (13%), side-effects of treatment (11%) and miscellaneous others. In decreasing order, prioritized concerns included: infecting family members, development of liver cancer, infecting others, development of cirrhosis, social stigma of having liver disease, need for liver transplant and loss of employment. The principal volunteered and prioritized concerns of follow-up patients were similar to those of newly diagnosed patients. Volunteered and prioritized concerns were relatively consistent across the different genders, age groups, ethnic backgrounds, education level, marital status, employment, modes of viral acquisition and in the case of follow-up patients, duration of follow-up. These results indicate that health care providers who focus counselling efforts exclusively on viral transmission are unlikely to address other important concerns of newly diagnosed and follow-up patients with chronic HCV infection. PMID:15655048

  4. Fukushima- Ocean Impacts and Public Concerns

    Science.gov (United States)

    Buesseler, K.

    2015-12-01

    The triple disaster of the March 11, 2011 earthquake, tsunami, and subsequent radiation releases at Fukushima Dai-ichi were unprecedented events for the ocean and society. This presentation will provide an overview of studies of Fukushima radionuclides in the ocean. The radioactive releases from Fukushima will be compared to natural and prior human sources. The fate of cesium is largely determined by its soluble nature in seawater, though uptake in sediments does occur via cesium's association with both detrital particles and biological uptake and sedimentation. Cesium's continued supply from the rivers and ongoing leakages at the nuclear power plants suggests that coastal sediments may remain contaminated for decades to come. Although levels of cesium in the ocean and being released from Fukushima more than four years later are orders of magnitude lower than in 2011, other isotopes such as strontium-90 remain of interest as they are elevated relative to cesium in the groundwater and storage tanks at the reactor site. Across the Pacific, Fukushima cesium is starting to be detectable along the west coast of North America. Although models suggest cesium will be at levels well below those considered of human health concern, the public is worried about the lack of ocean monitoring of Fukushima radionuclides. We addressed these public concerns by creating "Our Radioactive Ocean" a citizen-scientist crowd-funded campaign that provides a sampling kit that can use to sample their favorite beach. Once collected, samples are returned to WHOI for analyses of the isotopes of cesium that allow us to distinguish Fukushima cesium from other sources (http://OurRadioactiveOcean.org ). However to measure the low levels of cesium already in the ocean 20 liter samples are needed. To increase public participation, we will also present results from a new wearable sample collector, the "RadBand" which contains a small amount of cesium selective resin that surfers and swimmers can wear on

  5. Towards Separation of Concerns in Flow-Based Programming

    DEFF Research Database (Denmark)

    Zarrin, Bahram; Baumeister, Hubert

    2015-01-01

    Flow-Based Programming (FBP) is a programming paradigm that models software systems as a directed graph of predefined processes which run asynchronously and exchange data through input and output ports. FBP decomposes software systems into a network of processes. However there are concerns...

  6. Recent Advances Concerning Certain Class of Geophysical Flows

    CERN Document Server

    Li, Jinkai

    2016-01-01

    This paper is devoted to reviewing several recent developments concerning certain class of geophysical models, including the primitive equations (PEs) of atmospheric and oceanic dynamics and a tropical atmosphere model. The PEs for large-scale oceanic and atmospheric dynamics are derived from the Navier-Stokes equations coupled to the heat convection by adopting the Boussinesq and hydrostatic approximations, while the tropical atmosphere model considered here is a nonlinear interaction system between the barotropic mode and the first baroclinic mode of the tropical atmosphere with moisture. We are mainly concerned with the global well-posedness of strong solutions to these systems, with full or partial viscosity, as well as certain singular perturbation small parameter limits related to these systems, including the small aspect ratio limit from the Navier-Stokes equations to the PEs, and a small relaxation-parameter in the tropical atmosphere model. These limits provide a rigorous justification to the hydrost...

  7. 基于动态频谱博弈约束机制的认知无线网络信道选择算法%Cognitive radio network channel selection algorithm based on dynamic spectrum game binding mechanism

    Institute of Scientific and Technical Information of China (English)

    王思秀; 郭文强; 阿布都热合曼·卡的尔

    2015-01-01

    For the problem that cognitive wireless network channel access,to reduce interference between the channels au-thorized by the primary user of the second user,and increase the efficiency of channel utilization,this paper proposed a cogni-tive radio network channel selection algorithm based on dynamic spectrum game binding mechanism.First of all,it proposed a game constraint mechanism to analyze secondary users in the use of spectrum resources as well as the cost to harvest the bene-fits,constraints derived function spectrum allocation game,the spectral time selected by the user can be utilized as much as possible and to produce benefits improve the utilization of spectrum resources.Secondly,in order to choose a better access channel,channel selection method based on channel utilization,packet loss rate,power situation of these three performance indicators to select authorized idle channel.Simulation and comparison of experimental results show that the algorithm based on time series prediction method compared to the competition and cooperative spectrum access based method to reduce the delay in channel access interference and improve with better results on the channel utilization.%针对认知无线网络的信道接入问题,为减少在授权信道上次用户与主用户之间的互相干扰,并提高信道利用效率,提出一种基于动态频谱博弈约束机制的认知无线网络信道选择算法。首先提出一种博弈约束机制,分析次用户在利用频谱资源时所付出的成本以及所收获的效益,得出频谱分配博弈的约束函数,使次用户所选择的频谱能够尽可能地被利用并产生效益,提高频谱资源的利用率。为了选择更好的接入信道,采用基于信道利用率、丢包率、功率情况这三种性能指标的信道选择方法来选择授权的空闲信道。实验仿真及对比结果表明,该算法相比基于时间序列预测方法和基于竞争协作频谱接入方法

  8. Tourette Syndrome (TS): Other Concerns and Conditions

    Science.gov (United States)

    ... Articles & Key Findings Free Materials Info For Families Bullying Info for Health Professionals Info for Education Professionals ... concerns can be addressed with accommodations and behavioral interventions (for example, help with social skills). Accommodations can ...

  9. Special Concerns for Seniors: Clostridium difficile

    Science.gov (United States)

    ... Room Antibiotic Resistance in the News APUA Blog: "Superbugs and Drugs" Home | Contact Us Special Concerns for ... Resources Educators PBS Program on "Rx for Survival" Superbugs Drug Resistance and Social Norms CDC Get Smart ...

  10. Overview of Chemicals of Emerging Concern

    Science.gov (United States)

    Contaminants of emerging concern or environmental emerging contaminants, are chemicals, products and materials that are detected with increasing frequency in all environmental media including surface, ground water and drinking water. Examples of these contaminants include pharmac...

  11. Mild Air Pollution of Concern in Pregnancy

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_158558.html Mild Air Pollution of Concern in Pregnancy Study found risk for ... Being exposed to just a small amount of air pollution during pregnancy ups the risk of a pregnancy ...

  12. Comprehensive Oncologic Emergencies Research Network (CONCERN)

    Science.gov (United States)

    The Comprehensive Oncologic Emergencies Research Network (CONCERN) was established in March 2015 with the goal to accelerate knowledge generation, synthesis and translation of oncologic emergency medicine research through multi-center collaborations.

  13. Concerning bodies [stream convenors and panel chairs

    OpenAIRE

    Bartram, Angela; O'Neill, Mary

    2013-01-01

    The 'Concerning Bodies' stream is a collaboration with Eric Daffron (USA) and Becky McLaughlin (USA) that is part of the London Conference of Critical Thought, Royal Holloway University of London, 6-7 June 2013. The stream has two parallel strands detailed below: Stream Title: Concerning Bodies This stream has two points of focus: firstly, the representation, and ethical implications, of bodies (both human and animal) in visual cultures and, secondly, the account of the body (and bod...

  14. EXAMINING THE AUDIT CLIENTS GOING CONCERN

    OpenAIRE

    Lect. Prof. Sorinel Domnişoru Ph. D; Assist. Sorin-Sandu Vînătoru Ph.D Student; Mariana Gîrbaci Ph.D

    2010-01-01

    The paper discusses a very topical issue, under the conditions of the economic crisis, on the going concern of an entity and the manner in which the auditor can provide reasonable assurances to that effect. The going concern assumption is a fundamental principle for drafting the financial statements, which state that an entity is generally regarded as presenting a continuation of its work in the foreseeable future, having no intention or need to be liquidated, and to suspend its activity or t...

  15. Video display terminals - should operators be concerned

    International Nuclear Information System (INIS)

    Although modern offices have traditionally been thought to be among the safest places to work, over the past few years office workers have become concerned that video display terminals could be causing a variety of health problems. Extensive testing has occurred in many countries to determine if VDTs emit hazardous levels of ionizing or non-ionizing radiation. Results of these surveys suggest that radiation emissions are not of concern but that ergonomic factors in the office environment may need to be improved

  16. Measuring Knowledge of Technology Usage and Stages of Concern about Computing: A Study of Middle School Teachers.

    Science.gov (United States)

    Atkins, Nancy Ellen; Vasu, Ellen Storey

    2000-01-01

    Examined middle school teachers' concerns, knowledge, and use of technology in teaching, and how these related to their school's level of technology integration. Discusses the Computing Concerns Questionnaire; the Teaching with Technology Instrument; the Concerns Based Adoption Model; Stages of Concern about Computing; computer confidence;…

  17. Radioactive waste shipments and tribal concerns

    International Nuclear Information System (INIS)

    Several Indian tribes have registered concerns over the potential environmental, health, and safety and risks of transporting transuranic wastes to New Mexico's Waste Isolation Pilot Plant (WIPP) site. With the scheduled beginning of the WIPP test phase near at hand, the US Department of Energy (DOE) has sought to identify and accommodate tribal concerns. Appropriate DOE response to tribal concerns depends, in part, on understanding both the general nature of tribal interests and also the specific issues that individual tribes accord the greatest priority. Described here is the approach taken in the context of WIPP program activities to identify transportation-related tribal concerns, and to create an institutional arena for addressing these concerns by establishing cooperative agreements with two tribes whose jurisdictions are crossed by WIPP test-phase shipments. Special attention is directed to support for tribal activities involving public information, accident prevention, and emergency response; these activities are designed to enhance tribal capabilities for managing potential transportation-related impacts. 5 refs

  18. A Formal Study of the Privacy Concerns in Biometric-Based Remote Authentication Schemes

    OpenAIRE

    Tang, Qiang; Bringer, Julien; Chabanne, Hervé; Pointcheval, David; Chen, L; Mu, Y.; Susilo, W.

    2008-01-01

    With their increasing popularity in cryptosystems, biometrics have attracted more and more attention from the information security community. However, how to handle the relevant privacy concerns remains to be troublesome. In this paper, we propose a novel security model to formalize the privacy concerns in biometric-based remote authentication schemes. Our security model covers a number of practical privacy concerns such as identity privacy and transaction anonymity, which have not been forma...

  19. TPP and Intellectual Property: Growing Concerns

    OpenAIRE

    Amitendu Palit

    2013-01-01

    Promoted as a high-quality twenty-first century trade agreement for the Asia-Pacific, the Trans-Pacific Partnership (TPP) has generated concerns over several WTO plus issues it is negotiating. This article examines the concerns on intellectual property rules with respect to patents and copyrights. While large emerging markets like China and India are not part of the TPP, growth of a rigid intellectual property regime as proposed by the TPP in the Asia-Pacific, will have several implications f...

  20. Nuclear education and training: cause for concern?

    International Nuclear Information System (INIS)

    Mankind now enjoys many benefits from nuclear-related technologies. There is, however, growing concern in many OECD countries that nuclear education and training is decreasing, perhaps to problematic levels. This booklet, a summary of the full report, conveys the results of a pioneering survey on nuclear education and training in almost 200 organisations in 16 countries. The current situation is presented and causes for concern are examined. Recommendations are made as to the actions governments, academia and industry must take in order to assure that crucial present requirements are met and future options are not precluded. (authors)

  1. 计算机专业毕业设计教学质量评价模型的研究及应用*%Research and Application of the Evaluation Model Concerning Teaching Quality for Graduation Design of Computer Majors

    Institute of Scientific and Technical Information of China (English)

    张丽; 崔斌; 宋国建

    2013-01-01

      为了提高计算机专业毕业设计的教学质量,对其影响因素进行探讨,从专家和学生两个层面建立评价模型,采用专家咨询法对评价模型中的指标进行筛选和修改,然后利用AHP法计算各级各项指标的权重,运用模糊综合评判法对评价数据进行处理,得出计算机专业毕业设计教学质量评价的综合结果。%To improve the teaching quality for graduation design of computer majors, discusses the affect-ing factors. The evaluation model contains 2 bodies, experts and students, the expert consulta-tion method is used to screen and modify the indexes of the evaluation model, the AHP is used to determine the weight of every evaluation index, and the fuzzy comprehensive evaluation method was used to process the evaluation data, then gives the comprehensive result.

  2. Ethnic differences in ecological concerns: Spanish-speaking Hispanics are more concerned than others

    International Nuclear Information System (INIS)

    We postulated that environmental concern encompasses a wide range of different issues, often lumping pollution with habitat loss (or land use) and ecological resources (fish and wildlife). In this paper, we compare perceptions about a range of environmental and ecological resource issues, and explore ethnic/racial differences. We surveyed 1513 residents of New Jersey about 'environmental concerns', using both general environmental questions (two questions: How serious are environmental problems in New Jersey? Are you concerned about the loss of open space?) and ecological resource questions (12 questions: e.g., how important is planting trees in your neighborhood, how concerned are you about loss of breeding and feeding habitat for fish and birds?) in New Jersey. Not all concerns were rated equally. For the ecological questions, there were no ethnic differences in concerns over preserving areas around water supplies, loss of places to hunt and fish, and loss of places for quiet walks and cycling, but there were for the other 9 ecological concerns. For eight of these nine concerns, Spanish-speaking Hispanics were more concerned than others (including English-speaking Hispanics). We divided the ecological resources into three categories: ecological services (clean water and safety), ecological resources (fish and wildlife), and recreational services. The strongest correlates of people's association with enlarging and enhancing recreational services were Spanish-speaking Hispanics, who are supportive of regulations and believe local government is not doing enough for environmental problems. People concerned about the loss of ecological resources and open space believe the federal government and the state are not doing enough for the environment, were non-Hispanic White, want continued environmental regulations, were longer-term residents, were high school graduates, and were older (45-54 years). People interested in ecological services were college-educated, non

  3. An Investigation of How Teachers' Concerns Influence Innovation Adoption. Procedures for Adopting Educational Innovations Project.

    Science.gov (United States)

    Rutherford, William L.

    An overview is presented of the Concerns-Based Adoption Model, which describes the major factors influencing the decisions and actions of individuals in the innovation adoption process. The two critical indicators hypothesized by the model, Level of Use of the Innovation, and Stages of Concern About the Innovation, are discussed. The seven stages…

  4. Ethical Concerns: Negotiating Truth and Trust

    Science.gov (United States)

    McGarvey, Lynn M.; Sterenberg, Gladys

    2009-01-01

    Few studies in mathematics education explicitly address ethical issues arising from student interactions. The ethical concerns held by students are expressed in their words, actions, and interactions. The purpose of this article is to explore the ethical nature of copying as it arises in a mathematics classroom. We investigate the basis for…

  5. Hispanic Cultural Influence on Environmental Concern.

    Science.gov (United States)

    Noe, Francis P.; Snow, Rob

    1990-01-01

    The New Environmental Paradigm scale of environmental concern was applied in two survey populations to determine whether differences in ethnic background influenced preferences toward the environment. Results indicated that Hispanic users were ecologically attuned to the environment on a par with non-Hispanics from the general population.…

  6. Linguistic Privilege: Why Educators Should Be Concerned

    Science.gov (United States)

    Gallagher-Geurtsen, Tricia

    2007-01-01

    Awareness of privilege and the unearned power that it brings those who have it is a crucial aspect of becoming a multicultural educator. For some time White and male privilege has been a topic of discussion among educators and people concerned about social justice. All aspects of privilege need to be understood and articulated in order to continue…

  7. New Developments of the Shared Concern Method.

    Science.gov (United States)

    Pikas, Anatol

    2002-01-01

    Reviews and describes new developments in the Shared Concern method (SCm), a tool for tackling group bullying amongst teenagers by individual talks. The psychological mechanisms of healing in the bully group and what hinders the bully therapist in eliciting them have become better clarified. The most important recent advancement of the SCm…

  8. Understanding Teachers' Concerns about Inclusive Education

    Science.gov (United States)

    Yadav, Monika; Das, Ajay; Sharma, Sushama; Tiwari, Ashwini

    2015-01-01

    This study examined the concerns of regular elementary school teachers in Gurgaon, India, in order to work with students with disabilities in inclusive education settings. A total of 175 teachers responded to a two-part questionnaire. Data were analyzed using descriptive and inferential statistics. The data indicated that the teachers in Gurgaon,…

  9. Asian Pacific American Women's Health Concerns.

    Science.gov (United States)

    Pian, Canta

    This paper discusses the adjustment and acculturation problems of Asian Pacific American women and how these problems relate to their health concerns. Information presented in the article is based on the observations of health service providers to the Asian community. The paper suggests that the diversity of Asian Americans (age, ethnic group, and…

  10. Ensuring protection for LGBTI Persons of Concern

    Directory of Open Access Journals (Sweden)

    Volker Türk

    2013-04-01

    Full Text Available Lesbian, gay, bisexual, transgender and intersex (LGBTI asylumseekers and refugees face a myriad of threats, risks and vulnerabilitiesthroughout all stages of the displacement cycle. There needs to begreater awareness not only of the specific protection concerns relatingto LGBTI individuals but also of related jurisprudence and guidanceavailable for UN staff, partners, state authorities and decision-makers.

  11. Counseling Concerns for the Individual with Bulimia.

    Science.gov (United States)

    Leclair, Norma J; Berkowitz, Belinda

    1983-01-01

    Presents characteristics, medical concerns, treatment alternatives, and family issues for counselors working with nonhospitalized clients. Emphasis is placed on attending the interaction of the behavioral, cognitive, and affective domains in the client. Counselors should use interventions based on theory and research. (Author/JAC)

  12. Adolescent Homosexuality and Concerns Regarding Disclosure.

    Science.gov (United States)

    Harrison, Therese W.

    2003-01-01

    With threats of being labeled abnormal or facing rejection, homosexual adolescents are pressured to hide their sexual identities. To provide optimal anticipatory guidance and support, professionals must understand the natural development of sexual attraction and the disclosure concerns and risks for developing homosexual adolescents (e.g., risk…

  13. Emergency Preparedness Concerns for Older Adults

    Centers for Disease Control (CDC) Podcasts

    2009-01-26

    This podcast discusses the special concerns many older adults face during a disaster. It is primarily targeted to public health and aging services professionals.  Created: 1/26/2009 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) and Coordinating Office for Terrorism Preparedness and Emergency Response (COTPER).   Date Released: 1/26/2009.

  14. Mountains: Geology, Topography and Environmental Concerns

    Directory of Open Access Journals (Sweden)

    Martin F. Price

    2016-05-01

    Full Text Available Reviewed: Mountains: Geology, Topography and Environmental Concerns. Edited by António José, Bento Gonçalves, and António Avelino Batista Vieria. New York, NY: Nova Science Publishers, 2014. ix + 371 pp. US$ 175.00. ISBN 978-1-63117-288-5.

  15. Bioenergy Plants: Hopes, Concerns and Prospectives

    Institute of Scientific and Technical Information of China (English)

    Martin A.J.Parry; Hai-Chun Jing

    2011-01-01

    @@ There are major concerns over both the security of energy supplies (declining supplies and political control) and the en-vironmental costs associated with energy generation and use.The global consumption of carbon-containing fossil fuels for heat, electricity, transport and the manufacture of chemicals is not sustainable.

  16. The Concerns of Beginning Nursing Students.

    Science.gov (United States)

    Williams, Rhea P.

    1993-01-01

    A descriptive correlational study looked at the concerns of nursing students (n=245) as they began their nursing education program. Among the most stressful areas cited were academic work, long hours of study, lack of sufficient clinical knowledge and experience to complete the task, and relationship with faculty. (JOW)

  17. Behavior Analytic Consultation for Academic Referral Concerns

    Science.gov (United States)

    Dufrene, Brad A.; Zoder-Martell, Kimberly A.; Dieringe, Shannon Titus; Labrot, Zachary

    2016-01-01

    Applied behavior analysis provides a technology of human behavior that demonstrates great potential for improving socially important outcomes for individuals. School-based consultation may provide a vehicle for delivering applied behavior analysis services in schools to address academic referral concerns. In this article, we propose that…

  18. Statements on questions concerning nuclear energy

    International Nuclear Information System (INIS)

    Questions and answers compiled in this publication are excerpts from correspondence with citizens during the licensing procedure for the planned nuclear power plant. Subjects: Environmental impacts, environmental monitoring, earthquake safety, aircraft crashes, disaster control, questions concerning liability, waste management, energy and economy policies, and planning procedure. (HP)

  19. Common statistical concerns in clinical trials

    OpenAIRE

    Evans, Scott R.

    2010-01-01

    Statistics are an integral part of clinical trials. Elements of statistics span clinical trial design, data monitoring, analyses, and reporting. A solid understanding of statistical concepts by clinicians improves the comprehension and the resulting quality of clinical trials. This manuscript outlines common statistical concerns in clinical trials that are important for clinicians to understand.

  20. Software Architecture : Framing Stakeholders' Concerns introduction

    NARCIS (Netherlands)

    Lago, Patricia; Avgeriou, Paris; Hilliard, Rich

    2010-01-01

    As noted earlier, some stakeholder concerns are well-served today by available architecture viewpoints, frameworks, or ADLs, while others aren't expressible with available, off-the-shelf approaches. Hence the theme of this special issue: exploring the space of architecting in the face of multiple st

  1. What factors mediate the relationship between global self-worth and weight and shape concerns?

    Science.gov (United States)

    Murphy, Edel; Dooley, Barbara; Menton, Aoife; Dolphin, Louise

    2016-04-01

    The primary aim of this study was to investigate whether the relationship between global self-worth and weight concerns and global self-worth and shape concerns was mediated by pertinent body image factors, while controlling for gender and estimated BMI. Participants were 775 adolescents (56% male) aged 12-18years (M=14.6; SD=1.50). Mediation analysis revealed a direct and a mediated effect between global self-worth and two body image models: 1) weight concerns and 2) shape concerns. The strongest mediators in both models were physical appearance, restrained eating, and depression. Partial mediation was observed for both models, indicating that body image factors which span cognitive, affective, and behavioral constructs, explain the association between global self-worth and weight and shape concerns. Implications for future research, weight and shape concern prevention and global self-worth enhancement programs are discussed. PMID:26894257

  2. Environmental Concern and Rational Production, Consumption and Rehabilitation

    OpenAIRE

    Levy, Amnon

    2008-01-01

    Utility from consumption might be spoiled by the degradation of the environment. The incorporation of a direct dependency of utility on the state of the environment through environmental concern and the incorporation of the effects of production pollution and rehabilitative investment on the environment into a lifetime utility maximization model imply that a minimal degree of impatience is necessary for an interior steady state to exist. This steady state is unique, approachable along a path ...

  3. Airline strategic alliances in overlapping Markets: Should policymakers be concerned?

    OpenAIRE

    Gayle, Philip; Brown, Dave

    2015-01-01

    When there is significant overlap in potential partner airlines' route networks, policymakers have expressed concern that an alliance between such airlines may facilitate collusion on price and/or service levels in the partners' overlapping markets. The contribution of our paper is to put together a structural econometric model that is able to explicitly disentangle the demand and supply effects associated with an alliance between such airlines. The estimates from our structural econometric...

  4. Psychological Treatment of Social Anxiety Disorder Improves Body Dysmorphic Concerns

    OpenAIRE

    Fang, Angela; Sawyer, Alice T.; Aderka, Idan M.; Hofmann, Stefan G.

    2013-01-01

    Social anxiety disorder and body dysmorphic disorder are considered nosologically distinct disorders In contrast, some cognitive models suggest that social anxiety disorder and body dysmorphic disorder share similar cognitive maintenance factors. The aim of this study was to examine the effects of psychological treatments for social anxiety disorder on body dysmorphic disorder concerns. In Study 1, we found that 12 weekly group sessions of cognitive-behavioral therapy led to significant decre...

  5. 'Mum's the word': Predictors and outcomes of weight concerns in pre-adolescent and early adolescent girls.

    Science.gov (United States)

    Thøgersen-Ntoumani, Cecilie; Ng, Johan Yau Yin; Ntoumanis, Nikos; Chatzisarantis, Nikos; Vlachopoulos, Symeon; Katartzi, Ermioni S; Nikitaras, Nikitas

    2016-03-01

    Predictors and outcomes of weight concerns in pre-adolescent and adolescent girls are well known, but few models have incorporated concerns reported directly by mothers as a predictor, and both eating and exercise outcomes. Using questionnaires, a comprehensive model of 232 pre-adolescent and early adolescent girls' weight concerns, eating restraint, and exercise behavior was tested. Structural equation modeling showed that daughters' weight concerns were predicted primarily by their perceptions of their mothers' concerns about the daughters' weight, as well as by daughters' BMI, appearance conversations with friends, and perceived media pressure. Mothers' concerns with their daughters' weight were indirectly associated with daughters' own concerns, via the daughters' perceptions of their mothers' concerns. Daughters' concerns with their weight were a strong predictor of eating restraint, but not exercise behavior. PMID:26803392

  6. The Concerns of Competent Novices during a Mentoring Year

    Directory of Open Access Journals (Sweden)

    Susan Lennox

    2012-01-01

    Full Text Available In an innovative group mentoring approach, four experienced midwives mentored four new graduates during their first year of practice. The new graduates were in practice as case-loading registered midwives having completed a three year Bachelor of Midwifery degree. Detailed data about the new graduates’ concerns were collected throughout the year of the mentoring project. A range of practice areas—administrative, working environment, professional culture, clinical issues and the mentor group itself—were prominent issues. New graduates were concerned about their own professional development and about relationships with others particularly relationships within the hospital. Technical questions focussed more on craft knowledge that develops through experience than on clinical skills or knowledge. Identifying these concerns provides a foundation for mentors, preceptors and those designing professional development support programmes for the first year of practice. It may be that new graduate midwives educated in a profession with a narrowly defined scope of practice have a different range of concerns to new graduates who have wider scopes of practice. The use of a group model of mentoring for supporting new graduate midwives proved stimulating for mentors and highly supportive of new graduates.

  7. Are British Higher Educational Concerns Different from European Higher Educational Concerns?

    Science.gov (United States)

    Mangset, Marte

    2008-01-01

    British universities are known among the other Bologna countries not to have adjusted fully to the new common three-tier degree structure. Is it the case that British higher educational concerns are different from Continental concerns? A study of recent developments in two British graduate schools of history shows that a three-tier study structure…

  8. The Hospital Building as Project and Matter of Concern

    DEFF Research Database (Denmark)

    Harty, Chris; Tryggestad, Kjell

    2015-01-01

    negotiating the building design and project, including the exposition and resolution of controversy concerning size of spaces and bodies. The paper compares the use of two different forms of representation of the same imagined space—a single-bed room in a hospital, and produced for similar purposes......Mock-ups, scale models and drawings are ubiquitous in building design processes, circulating between various stakeholders. They contribute to the gradual evolution of design, but what else can specific material forms of representations do for the building design and project? The full-scale model of...... spaces and bodies....

  9. Relative concerns associated with genetics and surrogacy.

    Science.gov (United States)

    Kirk, M

    Assisted reproductive technologies, incorporating artificial insemination and in-vitro fertilization techniques, are widely practised across Europe. Concern about surrogacy prompted the UK Government to commission a review and consultation on surrogacy arrangements. The ensuing document was concerned primarily with the questions of payment to the surrogate, and the regulation of agencies involved in surrogacy arrangements. This author feels that more fundamental issues should first be debated by both health professionals and society. Genetic aspects of surrogacy merit special attention, particularly regarding the genetic contribution to parenthood and the ownership and use of genetic information. Health professionals need to be fully aware of the ethical implications of advances in genetics and technology when they are applied to assisted reproduction. PMID:9735720

  10. Environmental concerns gaining importance in industry operations

    International Nuclear Information System (INIS)

    This paper reports that environmental concerns have leapt to the forefront of industry's concerns in operating in Latin America. The United Nations Conference on Environment and Development in Rio de Janeiro June 3-14 focused a strong world spotlight on the region's environmental and commercial resources. Protection of the region's rain forests, which accounts for a huge share of the world's total, is emerging as an especially contentious issue. Ecuador's Oriente region may well prove the litmus test of how or whether oil and gas companies are able to operate in Latin American rain forests. Controversy over industry operations in the Oriente have heated to the point that environmentalist and native groups have routinely picketed company offices in Quito and used mass fundraiser mailings in North America

  11. WMPO project issues and public concerns

    International Nuclear Information System (INIS)

    The Governor of Nevada was notified in 1983 that the Yucca Mountain site is a potentially acceptable site for a nuclear waste storage site. A series of public hearings held produced nearly 400 comments on issues concerning the site nomination. Areas of primary public concern are the impact of the proposed nuclear site on tourism, transportation, and socioeconomic impact on adjacent communities. Results of recent studies showed no impact of high-level waste transport on tourism in the Las Vegas area and on analysis of data accumulated over the 25 to 30 years that high-level radioactive wastes have been transported on Nevada highways showed that no one has been evacuated from their home as the result of an accident involving radioactive waste. A comparison of the possible effects of construction of a nuclear waste storage facility at the Yucca mountain site with the effects of Nevada Test Site indicate that the impact on communities will be minimal

  12. Body Image and Body Dysmorphic Concerns.

    Science.gov (United States)

    Tomas-Aragones, Lucia; Marron, Servando E

    2016-08-23

    Most people would like to change something about their bodies and the way that they look, but for some it becomes an obsession. A healthy skin plays an important role in a person's physical and mental wellbeing, whereas a disfiguring appearance is associated with body image concerns. Skin diseases such as acne, psoriasis and vitiligo produce cosmetic disfigurement and patients suffering these and other visible skin conditions have an increased risk of depression, anxiety, feelings of stigmatization and self-harm ideation. Body image affects our emotions, thoughts, and behaviours in everyday life, but, above all, it influences our relationships. Furthermore, it has the potential to influence our quality of life. Promotion of positive body image is highly recommended, as it is important in improving people's quality of life, physical health, and health-related behaviors. Dermatologists have a key role in identifying body image concerns and offering patients possible treatment options. PMID:27283435

  13. RESEARCH CONCERNING ECONOMIC EFFICIENCY IN MILK PROCESSING

    OpenAIRE

    AGATHA POPESCU

    2013-01-01

    The paper presents a study case concerning economic efficiency of dairy products atAgro Industrial Milk Processing Company Baneasa , Bucharest . The most effectivedairy products are pressed cheese, green cheese, superior cow cheese, sheep cottagecheese, fresh cow cheese and whip cream. Production cost varies according toprocessing technology, specific consumption, price of raw materials, auxiliarymaterials, labor, energy, water. The company registered the highest profit Euro18,421 and the hig...

  14. Career Concerns of Mutual Fund Managers

    OpenAIRE

    Judith Chevalier; Glenn Ellison

    1998-01-01

    This paper examines the labor market for mutual fund managers and managers' responses to the implicit incentives created by their career concerns. We find that managerial turnover is sensitie to a fund's recent performance. Consistent with the hypothesis that fund companies are learning about managers' abilities, managerial turnover is more performance-sensitive for younger fund managers. Interpreting the separation-performance relationship as an incentive scheme, several of our results sugge...

  15. Career concerns and optimal disclosure policy

    OpenAIRE

    Mukherjee, Arijit

    2005-01-01

    Sequential contracting with multiple employers is a common feature of modern labor markets. Employment relations often terminate due to raids. When a worker is raided, the initial employer may enjoy an informational advantage over the raiders, as she is likely to have better information on the quality of her worker. If the worker has career concerns, and matching between firms and workers is important, the initial employer can strategically disclose this information to influence the worker's ...

  16. Stereotypes concerning Greeks in Serbian language

    Directory of Open Access Journals (Sweden)

    Ristić Stana

    2006-01-01

    Full Text Available Stereotypes concerning Greeks in Serbian language are researched through the historical source (Dictionary of JAZU. The source describes a complex representation, with a truthful foundation that incorporates layers of mythological and historical memories on stereotypes in the traditional culture. This ethnic stereotype of the people associated with Serbs in one very positive experience, both in mythological and historical legacies, is freed from prejudice, thus preventing a possibility of political misuse of its ethnic symbolism.

  17. Stereotypes concerning Greeks in Serbian language

    OpenAIRE

    Ristić Stana

    2006-01-01

    Stereotypes concerning Greeks in Serbian language are researched through the historical source (Dictionary of JAZU). The source describes a complex representation, with a truthful foundation that incorporates layers of mythological and historical memories on stereotypes in the traditional culture. This ethnic stereotype of the people associated with Serbs in one very positive experience, both in mythological and historical legacies, is freed from prejudice, thus preventing a possibility of po...

  18. Chicken pox in pregnancy : An obstetric concern

    OpenAIRE

    Wiwanitkit Viroj

    2010-01-01

    Chicken pox is a common viral infection presenting with fever and discrete vesicular lesions. This infection can be widely detected in developing countries, especially for those tropical countries. The pregnant can get chicken pox, and this becomes an important obstetrical concern. In this specific paper, the author hereby details and discusses on chicken pox in pregnancy. Clinical presentation, diagnosis, treatment, and prevention are briefly summarized. In addition, the effects of chicken p...

  19. Parental concerns in children requiring palliative care

    OpenAIRE

    Manjiri Dighe; Sunita Jadhav; Mary Ann Muckaden; Anuradha Sovani

    2008-01-01

    Children with advanced, life-limiting illness have unique needs which are different from those of adults. Pediatric palliative care is an under developed specialty. Aims : To identify concerns of parents of children with advanced, incurable cancers, and to elicit their attitudes toward revealing the diagnosis and prognosis to the sick child. Method : This study was carried out in a large tertiary cancer center in India. Parents of 20 pediatric palliative care patients attending the ou...

  20. Procedural Issues Concerning Environmental Damage In Ecuador

    Directory of Open Access Journals (Sweden)

    René Bedón Garzón

    2013-01-01

    Full Text Available This paper aims to determine, through a deep analysis of different doctrines, the definition of environmental damage; it also seeks to determine the difference between damage to nature and the civil environmental damage, which is damage to individual interests or collective environmental event occasion. To this purpose, we intend to study certain procedural rules and case law concerning Ecuadorian environmental management, also in comparative law considers how countries like Chile, Spain and Argentina regulate compensation and repair environment.

  1. Finnish Consumer Attitudes Concerning Organic Foods

    OpenAIRE

    Peart, Joel

    2013-01-01

    This thesis was written as an independent study on the topic of consumer behaviour concerning organic grocery consumption. The main objective of the thesis was to find out the factors that influence attitude, belief and behaviour towards organic foods in both organic and non-organic consumer segments. The goal was to show how attitude and beliefs are affecting the overall popularity of organic food in Finland. The theoretical framework is based on consumer behaviour and to a less extent also ...

  2. REPERTORY SUGGESTIONS CONCERNING VIRTUOSITY IN KEMANCHA

    OpenAIRE

    Kaya, Filiz

    2013-01-01

    This study aims to stress the importance of the virtuosity in Turkish Music and to propose repertory suggestions concerning virtuosity in four-stringed kemancha. Research universe consists of faculties providing kemancha education in Turkey, TRT Radio, Ministry of Culture and Tourism state choirs and people working in private organizations. Sampling of this study consist of 11(eleven) people of various professions such as experts, researches, artists and scholars who participated in this...

  3. Child Homicide: A Global Public Health Concern

    OpenAIRE

    Naeemah Abrahams; Shanaaz Mathews; Martin, Lorna J.; Carl Lombard; Nadine Nannan; Rachel Jewkes

    2016-01-01

    Editors' Summary Background Child mortality (death) is a global public health concern. In 2015, 5.9 million children (43 out of every 1,000 children born alive) died before their fifth birthday. Nearly half of these deaths occurred among neonates (babies 28 days old or younger); three-quarters of them occurred among infants (children less than one year old). Most of these deaths happened in resource-limited countries following delivery complications, infections, and other natural causes. Some...

  4. Status concerns and the organization of work

    OpenAIRE

    Chaim FERSHTMAN; Hvide, Hans K.; Weiss, Yoram

    2001-01-01

    We study the effects of local status, where workers compare their wage to the wage of other workers within the same firm. We assume a competitive labor market with unobservable effort, where firms condition wages on output as incentive for effort. If workers who care about status are also more productive, such status concerns generate an equilibrium with heterogenous firms where workers who care and workers who do not care about status work together. Such firms provide workers who care about ...

  5. Contracting with Self-Esteem Concerns

    OpenAIRE

    Junichiro Ishida

    2006-01-01

    It is widely accepted in social psychology that the need to maintain and enhance self-esteem is a fundamental human motive. We incorporate this factor into an otherwise ordinary principal-agent framework and examine its impact on the optimal incentive scheme and the agent's behavior, especially focusing on a form of intrapersonal strategy known as self-handicapping. Incorporating self-esteem concerns into a contracting situation yields an implication that goes against the conventional wisdom:...

  6. Wood combustion systems: status of environmental concerns

    Energy Technology Data Exchange (ETDEWEB)

    Dunwoody, J.E.; Takach, H.; Kelley, C.S.; Opalanko, R.; High, C.; Fege, A.

    1980-01-01

    This document addresses the uncertainties about environmental aspects of Wood Combustion Systems that remain to be resolved through research and development. The resolution of these uncertainties may require adjustments in the technology program before it can be commercialized. The impacts and concerns presented in the document are treated generically without reference to specific predetermined sites unless these are known. Hence, site-specific implications are not generally included in the assessment. The report consists of two main sections which describe the energy resource base involved, characteristics of the technology, and introduce the environmental concerns of implementing the technology; and which review the concerns related to wood combustion systems which are of significance for the environment. It also examines the likelihood and consequence of findings which might impede wood commercialization such as problems and uncertainties stemming from current or anticipated environmental regulation, or costs of potential environmental controls. This document is not a formal NEPA document. Appropriate NEPA documentation will be prepared after a formal wood combustion commercialization program is approved by DOE.

  7. Relation of dreams to waking concerns.

    Science.gov (United States)

    Cartwright, Rosalind; Agargun, Mehmet Y; Kirkby, Jennifer; Friedman, Julie Kabat

    2006-03-30

    To test that dreams are influenced by the pre-sleep waking emotional concerns of the sleeper and have an effect on waking adaptation, 20 depressed and 10 control subjects, who were all going through a divorce, were enrolled in a repeated measures study lasting 5 months. A Current Concerns test was administered on three occasions before nights when every REM period was interrupted to record recalled mental content. The degree of waking concern about the ex-spouse correlated significantly with the number of dreams in which the former partner appeared as a dream character. Those who were in remission at the follow-up evaluation had a higher percentage of well-developed dreams than those who remained depressed. Dreams of the former spouse reported by those in remission differed from those who remained depressed in the expression of dream affect and in the within-dream linkage among units of associated memory material. Dreams of the former spouse that are reported by those who are not in remission lack affect and connection to other memories. PMID:16497389

  8. Optimal Managerial Contracts with Self-Esteem Concerns When Managers Can Hedge

    OpenAIRE

    Chongwoo Choe; Donald Lien; Chia-Feng Yu

    2013-01-01

    We study an optimal contracting problem when the manager has self-esteem concerns and access to a hedging market. We show that the manager's equilibrium hedging position increases when he is more risk-averse, more uncertain about his own ability, or has stronger self-esteem concerns. Each element of managerial hedging and self-esteem concerns added to an otherwise standard agency model increases the equilibrium pay-performance sensitivity. The agency cost increases as the manager's self-estee...

  9. The Usefulness of Truth : An Enquiry Concerning Economic Modelling

    OpenAIRE

    Deichsel, Simon

    2009-01-01

    This thesis attempts to justify a normative role for methodology by sketching a pragmatic way out of the dichotomy between two major strands in economic methodology: empiricism and postmodernism. I discuss several methodological approaches and assess their aptness for theory appraisal in economics. I begin with the most common views on methodology (i.e. empiricism and postmodernism) and argue why they are each ill-suited for giving methodological prescriptions to economics. Then, I consider p...

  10. Some transboundary environmental issues of public concern

    International Nuclear Information System (INIS)

    There are two complementary approaches to studying the environmental effects of fuel use and energy conversion. The first approach is to be completely systematic and to follow through each technology in great detail, and to itemize each impact, whether large or small. The second approach, followed here, is to pick out those items that dominate either the risk or impact or the public perception thereof, and try to understand them in some detail. The following items are discussed in the paper: (a) The probability and effect of a severe nuclear power accident. Experts believe that the probability of a severe accident in a pressurized water reactor is small, and the effect would be far less than the effect of the Chernobyl accident. But a large number of people believe otherwise; (b) The effect upon health of particulate air pollution at the present levels. More and more experts believe that particulates kill 70,000 people per year in the United States of America, but this has not yet been officially admitted by any Government; (c) The probability that increased carbon dioxide emissions from burning fossil fuels will cause a global climate change. There was intense Government attention at the meeting in Rio de Janeiro in 1992 and at the meeting in Berlin in 1995. But the estimates of the Intergovernmental Panel on Climate Change have decreased over the last five years; (d) Although there is public concern about nuclear waste, this is not justified by the calculations. The points discussed in the paper are: the reasons for this concern and the question why there is not comparable concern about coal waste. A final issue is very important, namely the effect of the technology on the outbreak of a catastrophic war, such as might be caused by proliferation of nuclear weapons among many States. (author). 29 refs, 1 tab

  11. Environmental concerns and diet in Singapore.

    Science.gov (United States)

    Burger, Joanna; Fleischer, Jennifer; Jeitner, Chris; Gochfeld, Michael

    2003-08-01

    Many factors affect how people perceive the world and their environment, and how such perceptions affect lifestyle decisions, yet the relationship between personal perceptions about environmental hazards and diet is rarely examined. In this study, environmental concerns on a local and global scale were examined, along with dietary patterns, to determine if there were associations and age-related differences. The hypothesis that concerns about water pollution might be reflected in choices about seafood consumption was examined. Many aspects of dietary choices varied significantly by age, including (1) younger people ate more "fast food" than others, (2) subjects aged 22-32 yr ate more meals in restaurants than older or younger people, (3) older individuals drank more tea than younger subjects, while younger people drank more soda than older people, and (4) there were few significant differences in total fish and shellfish meals, although young people ate more meals of other types of meat. Individuals who rated their health the best reported significantly fewer seafood meals than others. People who listed pollution as the major environmental problem did not consume seafood less often than others. While pollution was listed as the most important environmental problem globally, people distinguished between air and water pollution only for Singapore. Although Singapore, with its rapidly expanding economy, has reason to be concerned about both water and air pollution, only 14% of those listing pollution as the main Singapore environmental problem mentioned "water pollution." Singapore has been able to take measures to reduce water pollution from internal sources. Respondents considered air pollution a greater problem, perhaps reflecting recent haze disasters from deliberately set forest fires in Indonesia, which are beyond the direct control of Singapore or Singaporeans. PMID:12857632

  12. Fears and concerns - The public perception

    International Nuclear Information System (INIS)

    The terrorist attacks of 11 September 2001 took place more than six years ago and happened far away, but for many people, time and distance simply cannot push aside the danger they represent. A study published by one of Germany's major insurance companies shows that public fears with respect to terrorist attacks rose in 2007 compared with 2006. With respect to nuclear terrorism, the expectation is that there is no overwhelming concern since there has been no nuclear attack so far. As it turns out, however, the contrary is true. The paper discusses how to deal with the public perception of nuclear terrorism, and ponders what the best strategy would be. (author)

  13. Social Media: Challenges and Concerns for Families.

    Science.gov (United States)

    O'Keeffe, Gwenn Schurgin

    2016-10-01

    This article explores the impact of social media on child development and family health. Why do we allow our children to use social media sites before their privacy policies allow? Why do we let them lie about their ages to use these sites? What is it about technology that lets us bend these rules in a way we would never do in the unplugged world? Gaining insight into the answers to these questions and what is positive and negative about social media and the digital world allows us to talk to families about this world, allay their concerns, and keep children of all age safe when using social media. PMID:27565362

  14. Chicken pox in pregnancy : An obstetric concern

    Directory of Open Access Journals (Sweden)

    Wiwanitkit Viroj

    2010-01-01

    Full Text Available Chicken pox is a common viral infection presenting with fever and discrete vesicular lesions. This infection can be widely detected in developing countries, especially for those tropical countries. The pregnant can get chicken pox, and this becomes an important obstetrical concern. In this specific paper, the author hereby details and discusses on chicken pox in pregnancy. Clinical presentation, diagnosis, treatment, and prevention are briefly summarized. In addition, the effects of chicken pox on pregnancy as well as the vertical transmission are also documented.

  15. Post mortem examination report concerning Nadim Nuwwara

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    2014-01-01

    Post mortem examination report concerning Nadim Nuwawara, 17-years old, who was killed may 15 2014 in Beitunia near Rahmallah, Palestine. The examination was performed by an international team consisting of dr. Saber Al-Aloul, director of the Medico Legal Institute at Quds University, dr. Marc A....... Krouse, Deputy Chief Medical Examiner, Office of Chief Medical Examiner, Fort Worth, Texas, USA, dr. Chen Kugel, Chief Forensic Pathologist, Abu Kabir Institute of Forensic Medicine, Tel Aviv, dr. Ricardo Pablo Nachman, forensic expert at Abu Kabir Institute of Forensic Medicine, Tel Aviv and dr. Peter...

  16. Consumer perceptions and reactions concerning AI

    OpenAIRE

    Figuié, Muriel; Food and Agriculture Organization of the United Nations

    2007-01-01

    This paper focuses on the results of different consumer surveys conducted between 2004 and 2006 with regard to consumers’ perceptions and reactions concerning AI in Vietnam, (mainly in Hanoi). The main results observed are as follows: A high proportion of consumers consider AI to be a food-related risk. However, over time,there has been a slight shift from a fear of consuming poultry to a fear of preparing it (slaughtering it). AI has had a profound effect on poultry consumption, even outside...

  17. RESEARCH CONCERNING ECONOMIC EFFICIENCY IN MILK PROCESSING

    Directory of Open Access Journals (Sweden)

    AGATHA POPESCU

    2013-12-01

    Full Text Available The paper presents a study case concerning economic efficiency of dairy products atAgro Industrial Milk Processing Company Baneasa , Bucharest . The most effectivedairy products are pressed cheese, green cheese, superior cow cheese, sheep cottagecheese, fresh cow cheese and whip cream. Production cost varies according toprocessing technology, specific consumption, price of raw materials, auxiliarymaterials, labor, energy, water. The company registered the highest profit Euro18,421 and the highest profit rate 15.32 % in the year 2004. The continuousincrease of inputs and manufacturing costs has a deep impact on efficiency.

  18. Attitudes Concerning Wind Energy in Central Illinois

    OpenAIRE

    Theron, Sophie; Winter, J. Randy; David G. Loomis; Spaulding, Aslihan D.

    2011-01-01

    Energy consumption in the United Sates has been increasing and the cost of fossil fuels has been unstable in recent years. Expanding investment in renewable energy is one way to reduce the nation’s dependence on fossil fuels. However, the Not-In-My-Back- Yard (NIMBY) opposition and various concerns raised at public hearings may inhibit the expansion of wind energy in Illinois. This study aims to characterize the public beliefs and opinions toward wind energy in central Illinois.

  19. Equity Concerns over Climate Change Mitigation

    Institute of Scientific and Technical Information of China (English)

    Chen Ying; Pan Jiahu

    2004-01-01

    As a complicated concept with ethical implications, equity or fairness in the field of climate change mitigation concerns the relations not only between individual human beings but also between human beings and the nature. In this paper, after the review of equity between individuals, market and non-market attributes of emissions rights are distinguished and discussed. Based on the argument of equal per capita emissions rights, three types of emissions rights and the concept of minimum emissions rights as social security are proposed.

  20. Radiation safety concerns during interventional radiology

    International Nuclear Information System (INIS)

    Interventional radiological procedures are on the increase by virtue of the fact that these procedures replace highly invasive surgical and other procedures. Radiation dose to patients and hospital workers are of significance since these procedures tend to impart large dose to them. Moreover, long term risk from radiation absorbed by patients is of concern since the life expectancy of major fraction of patients is long after undergoing the procedure. This study intends to measure radiation dose imparted to patients as well as personnel- radiologists, technologists, nurses, etc. and estimate the risk factor involved

  1. Pet Food Safety A Shared Concern

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, Robert L [University of Maryland; Baker, Robert C [Mars, Inc.; Charlton, Adrian J [UK Food and Environmental Research Agency, Sand Hutton, York, UK; Riviere, Jim E [North Carolina State University; Standaert, Robert F [ORNL

    2011-01-01

    The safety of the food supply is a subject of intense interest to consumers, particularly as a result of large scale outbreaks that involve hundreds and sometimes thousands of consumers. During the last decade this concern about food safety has expanded to include the diets of companion animals as a result of several incidences of chemical toxicities and infectious disease transmission. This has led to increased research into the causes and controls for these hazards for both companion animals and their owners. The following summary provides an introduction to the issues, challenges, and new tools being developed to ensure that commercial pet foods are both nutritious and safe.

  2. Paediatric suicidal burns: A growing concern.

    Science.gov (United States)

    Segu, Smitha; Tataria, Rachana

    2016-06-01

    An alarming rise in rates of paediatric population committing self-immolation acts is a growing social and medical problem. In recent times there seems to be a rising concern in paediatric population. A study was conducted at a government tertiary care burn centre over 5 years in paediatric age group of peer pressure leaving them vulnerable. A multidisciplinary care involving medical, psychological and social support is required. Identifying children at risk and proper counselling and support can form an important strategy at prevention rather than cure. PMID:26803366

  3. How granularity issues concern biomedical ontology integration.

    Science.gov (United States)

    Schulz, Stefan; Boeker, Martin; Stenzhorn, Holger

    2008-01-01

    The application of upper ontologies has been repeatedly advocated for supporting interoperability between domain ontologies in order to facilitate shared data use both within and across disciplines. We have developed BioTop as a top-domain ontology to integrate more specialized ontologies in the biomolecular and biomedical domain. In this paper, we report on concrete integration problems of this ontology with the domain-independent Basic Formal Ontology (BFO) concerning the issue of fiat and aggregated objects in the context of different granularity levels. We conclude that the third BFO level must be ignored in order not to obviate cross-granularity integration. PMID:18487840

  4. Concerns about the future of creation order

    Directory of Open Access Journals (Sweden)

    A.H. Verhoef

    2011-09-01

    Full Text Available The theological background to the notion of the law of nature/ creation order is indispensable to the reformational tradition, which recognises that these laws are the Creator‟s will, and therefore holds a “necessity” view of these laws. There has, however, been a longstanding debate about the nature of law within the reformational tradition, where its origin and its status as boundary between God and creation have been questioned. In this article I will investigate how Trinitarian theology, specifically that of Robert W. Jenson, relates to process philosophy and theology, and how together they create some theological concerns about the future of creation order. Some of the concerns include the following: that the necessity of order is questioned (the disappearance of a Creator who wills these laws; that order is temporal and in constant change; and that the boundary between God and creation is weakened. I will raise some objections to these aspects, but will also highlight some questions the reformational tradition has to answer in terms of its understanding of the immanence of God and of the implicated theological basis for the creation order. These questions are of the utmost importance for the understanding of the future of creation order.

  5. Parental concerns in children requiring palliative care

    Directory of Open Access Journals (Sweden)

    Manjiri Dighe

    2008-01-01

    Full Text Available Children with advanced, life-limiting illness have unique needs which are different from those of adults. Pediatric palliative care is an under developed specialty. Aims : To identify concerns of parents of children with advanced, incurable cancers, and to elicit their attitudes toward revealing the diagnosis and prognosis to the sick child. Method : This study was carried out in a large tertiary cancer center in India. Parents of 20 pediatric palliative care patients attending the outpatient department were interviewed and emerging themes identified. Results : Parents showed varying degrees of anticipatory grief. Most families were financially strained. Most parents were reluctant to discuss disease and dying with the child. Siblings were rarely told or directly involved in care. There was resistance to allowing the palliative care team to communicate with the patient. Patients did not receive any formal support. Parents identified family and neighbors as the main sources of support. Conclusions : Parental attitudes hinder open communication with dying children in India. There is a need for research to explore the concerns of families of children with fatal illness. Specialist training is required for professionals working in pediatric palliative care to address this issue.

  6. The law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    This Law aims at determining the basic system concerning indemnification for nuclear damage caused by the operation of reactors, fabrication, reprocessing and use of nuclear fuel materials as well as the transportation, storing or disposal of such materials or those contaminated by such materials (including fission products) accompanying these operations in view of protecting the sufferers and contributing to the wholesome development of atomic energy enterprises. The ''nuclear damage'' referred to in this Law is the damages caused by the action during the process of fission of nuclear fuel materials or the action of radiation or the poisonous action of said nuclear fuel materials or matters contaminated by said materials (those causing poisoning or deuteropathy in human bodies by taking in or inhaling such materials). Upon giving nuclear damage by the operation of reactors and others, the atomic energy entrepreneurs concerned are responsible for indemnifying the damage. Atomic energy entrepreneurs should not operate reactors without first taking the measures for indemnifying nuclear damages. Said measures are conclusion of nuclear damage indemnification responsibility insurance contract and nuclear damage indemnification contract or deposit, by which 6,000 million yen may be earmarked for such indemnification per factory, place of business or nuclear ship

  7. Teachers' Concerns and Efficacy Beliefs about Implementing a Mathematics Curriculum Reform: Integrating Two Lines of Inquiry

    Science.gov (United States)

    Charalambous, Charalambos Y.; Philippou, George N.

    2010-01-01

    This study brings together two lines of research on teachers' affective responses toward mathematics curriculum reforms: their concerns and their efficacy beliefs. Using structural equation modeling to analyze data on 151 elementary mathematics teachers' concerns and efficacy beliefs 5 years into a mandated curriculum reform on problem solving,…

  8. Global Governance: Some concerns about authentic democracy addressed

    Directory of Open Access Journals (Sweden)

    Gillian Brock

    2011-05-01

    Full Text Available In this paper I take up a commonly voiced concern about the viability of global governance in general, and cosmopolitan democracy in particular, namely, whether genuine democracy can be achieved at the international level. Some (such as, Will Kymlicka argue that genuine democracy is only possible within nation-states, because authentic deliberation requires common nationality or identity, which generates the trust and solidarity necessary to sustain deliberation and democracy. Through analysis of the argument and consideration of the requirements of genuine democracy, we can see that these concerns can be addressed. I go on to suggest that the major challenge facing models of global governance is not one concerning lack of common identity, solidarity, or opportunities for authentic deliberation, rather, it lies elsewhere. We can assess global governance arrangements in terms of two main variables, which are sometimes in tension: effectiveness and accountability. We want systems of global governance to incorporate both considerations. Accountability can take the form of democratic procedures but alternative forms of accountability are also possible. Furthermore, a system of governance that both effectively attends to people’s interests and is suitably accountable can certainly claim to have adequate democratic credentials on the “Responsive Democracy” view I discuss. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=1837317

  9. ORAL CANCER ITS ETIOLOGY & CONCERNS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Anitha

    2015-07-01

    Full Text Available Oral cancer is the largest group of cancer that categorizes into the head and neck region and worldwide health problem. Exact cause of oral cancer is unknown. Risk factors for cancer could be varied including Iron deficiency anemi a, are alcohol, tobacco, immunologic susceptibility, gene mutations, epithelial cell growth, suppressor proteins and disease of chemotherapy, such as in cases of lymphoma and leukemia. Role of viruses have also been reported in the etiology. Dietary factor s such as high fat and low fiber may play a role in carcinogenesis in some sites. High incidence of alcoholism is relevant because alcohol intake has been related to an increase risk of developing oral cancer. Other signaling factors have also been propose d to have a role. The paper presents a review on oral cancer, its causes & concern.

  10. Some Findings Concerning Requirements in Agile Methodologies

    Science.gov (United States)

    Rodríguez, Pilar; Yagüe, Agustín; Alarcón, Pedro P.; Garbajosa, Juan

    Agile methods have appeared as an attractive alternative to conventional methodologies. These methods try to reduce the time to market and, indirectly, the cost of the product through flexible development and deep customer involvement. The processes related to requirements have been extensively studied in literature, in most cases in the frame of conventional methods. However, conclusions of conventional methodologies could not be necessarily valid for Agile; in some issues, conventional and Agile processes are radically different. As recent surveys report, inadequate project requirements is one of the most conflictive issues in agile approaches and better understanding about this is needed. This paper describes some findings concerning requirements activities in a project developed under an agile methodology. The project intended to evolve an existing product and, therefore, some background information was available. The major difficulties encountered were related to non-functional needs and management of requirements dependencies.

  11. Visually depicting cancer fears: Beyond biomedical concerns

    Directory of Open Access Journals (Sweden)

    Carolyn Brooks

    2014-07-01

    Full Text Available This manuscript is a reaction to the high prevalence of breast cancer amongst Aboriginal women. Our work calls for more attention to the effects of race, gender, and class on cancer fears and related experiences. The shock of a cancer diagnosis and fears of recurrence can leave patients feeling that their lives are out of control. Combining the visual method of photovoice with focus groups and in-depth interviews, we develop an understanding of cancer experiences that includes fears related to: socio-economic realities; supporting families both emotionally and financially; environmental concerns, especially those that arise from living on reserve; race and racism; and cultural beliefs. Breast cancer experiences are shown to be significantly linked to history and the impact of colonization, neo-colonialism and point to the importance of a postcolonial feminist framework and cancer support policies informed by a lens of cultural safety.

  12. Operational concerns in addressing insider protection

    International Nuclear Information System (INIS)

    One of the greater challenges facing today's nuclear industry is developing and implementing an insider protection system. Thorough employee background investigations alone do not suffice as the system to assure that the authorized employee does not sabotage the facility. The real difficulties arise when physical or administrative barriers are placed in the operational environment of the plant. People have to be used to control the plant, and usually production is a key priority of management responsibilities. Implementing an insider protection system that provides the least operational impacts and meets the intended safeguards objectives has to be approached with a team attitude by all of management. Operational concerns are some of the most important considerations that must be factored into the insider protection system

  13. Certain problems concerning wavelets and wavelets packets

    International Nuclear Information System (INIS)

    Wavelets is the outcome of the synthesis of ideas that have emerged in different branches of science and technology, mainly in the last decade. The concept of wavelet packets, which are superpositions of wavelets, has been introduced a couple of years ago. They form bases which retain many properties of wavelets like orthogonality, smoothness and localization. The Walsh orthornomal system is a special case of wavelet packet. The wavelet packets provide at our disposal a library of orthonormal bases, each of which can be used to analyze a given signal of finite energy. The optimal choice is decided by the entropy criterion. In the present paper we discuss results concerning convergence, coefficients, and approximation of wavelet packets series in general and wavelets series in particular. Wavelet packet techniques for solutions of differential equations are also mentioned. (author). 117 refs

  14. Three dialogues concerning robots in elder care.

    Science.gov (United States)

    Metzler, Theodore A; Barnes, Susan J

    2014-01-01

    The three dialogues in this contribution concern 21st century application of life-like robots in the care of older adults. They depict conversations set in the near future, involving a philosopher (Dr Phonius) and a nurse (Dr Myloss) who manages care at a large facility for assisted living. In their first dialogue, the speakers discover that their quite different attitudes towards human-robot interaction parallel fundamental differences separating their respective concepts of consciousness. The second dialogue similarly uncovers deeply contrasting notions of personhood that appear to be associated with respective communities of nursing and robotics. The additional key awareness that arises in their final dialogue links applications of life-like robots in the care of older adults with potential transformations in our understandings of ourselves - indeed, in our understandings of the nature of our own humanity. This series of dialogues, therefore, appears to address a topic in nursing philosophy that merits our careful attention. PMID:24320977

  15. Acoustic concerns related to multi cultural societies

    DEFF Research Database (Denmark)

    Gade, Anders Christian

    2001-01-01

    Denmark. Its purpose is to combine visual and acoustical concerns in the identification, conservation, and restoration of architectural heritage. It focuses on the famous Turkish mosques of the Osmannic architect Sinan. Some of the acoustic features of these large domed buildings and of muslim liturgy......Immigration has increased cultural diversity in western societies. The process of integrating immigrants into their host countries can be smoothed if acousticians learn to recognize (1) the acoustic traditions of immigrant cultures and (2) the specific acoustic needs of the new society members. Two...... related projects are discussed. The ``Cahrisma'' project (Conservation of Acoustical Heritage by the Revival and Identification of the Sinan's Mosque Acoustics) is sponsored by the European Commission and carried out in cooperation among researchers in Turkey, Malta, Italy, France, Switzerland, and...

  16. Sexual concerns and practices after ICD implantation

    DEFF Research Database (Denmark)

    Berg, Selina Kikkenborg; Elleman-Jensen, Line; Zwisler, Ann-Dorthe;

    2013-01-01

    Background:Studies show that patients with implantable cardioverter defibrillators (ICD) frequently experience sexual dysfunction. These experiences are often linked to exercise intolerance, side-effects of medication, and psychological problems.Objective:To describe (a) the level of information...... given about sexual activity, (b) the areas of patient concerns related to sexual function and the ICD, and (c) changes in sexual behavior.Methods:A randomized controlled trial including 196 patients (1:1) was designed, including 12 weeks of exercise training and 1 year of psycho-educational follow......-up focusing on modifiable factors associated with poor outcomes, including sexual functioning. The Sex After ICD Survey was administered 6 months after the randomization as part of the planned explorative outcomes. 141 patients responded.Results:The analyses showed that 37 of the 69 (55.2%) patients of the...

  17. Caffeinated alcohol beverages: a public health concern.

    Science.gov (United States)

    Attwood, Angela S

    2012-01-01

    Consumption of alcohol mixed with caffeinated energy drinks is becoming popular, and the number of pre-mixed caffeinated alcohol products on the worldwide market is increasing. There is public health concern and even occasional legal restriction relating to these drinks, due to associations with increased intoxication and harms. The precise nature and degree of the pharmacological relationship between caffeine and alcohol is not yet elucidated, but it is proposed that caffeine attenuates the sedative effects of alcohol intoxication while leaving motor and cognitive impairment unaffected. This creates a potentially precarious scenario for users who may underestimate their level of intoxication and impairment. While legislation in some countries has restricted production or marketing of pre-mixed products, many individuals mix their own energy drink-alcohol 'cocktails'. Wider dissemination of the risks might help balance marketing strategies that over-emphasize putative positive effects. PMID:22645036

  18. Concerning ecological reconstruction around nuclear facilities

    International Nuclear Information System (INIS)

    This paper presents briefly some aspects thought to be important in what concerns the diminution of the total impact that the realization and operation of nuclear facilities bring about. Particularly, highlighted is the reconstruction of ecological equilibrium, the change of which is induced by the whole chain of activities implied in the nuclear fuel cycle, starting with uranium extraction from uranium ores, up to its use in the nuclear power plant. Predictive estimates are attempted in connection with cessation of implied activities. As solutions for ecological reconstruction, the following are considered: land reclamation by re-shaping the slopes and by covering with fertile earth the sterile dumps resulting from exhausted uranium mines and by implanting fresh vegetation with deeply penetrating roots able to stabilize the ground; cleaning the access galleries of the access and ventilation wells; drying and draining the access water in bulk solid wastes and in the open decantation pools; slope stabilization, covering with fertile soil and grass and bush cultivation; decontamination of buildings; utilisation of inactive and isolated mines for low and intermediate activity radioactive waste disposal; closing and covering with layered structure of earth, draining materials, clay, fertile soil and grass and bush cultivation of organized containerized low and intermediate activity radioactive waste repositories; long-term monitoring of surfaces and underground waters at closed mines, decantation pools underground or overground radioactive waste repositories; storing the plutonium contaminated soil in trenches covered by a layer of non-infested earth of minimum 5 m thickness and in-situ vitrification by means of a high intensity current. These are principles set forth by IAEA concerning the radioactive waste management

  19. Regulations concerning radiation protection and survey

    International Nuclear Information System (INIS)

    The many and always increasing applications of Atomic Energy for peaceful uses set many safety and security problems relatively to the workers, populations, and locating of the sites in general. A comparative study of the radiation hazards to which the people working in the 'Commissariat a l'energie atomique' installations were exposed during 1957 and the results obtained concerning individual and collective safety and security were extremely satisfactory owing to a continuous control and supervision. 2. However a few contamination and irradiation incidents - exposed subsequently as well as the way they were dealt with - show the necessity of a circumstantial regulation inside of an atomic center to establish the responsibility of the service in charge of the control of the radiation and the responsibility of the services using radioactive products with regard to contamination by radioactive materials. 3. Abstract of the different practical safety and security regulations concerning holding, manipulation, transport and stocking of radioactive materials. Pursuant to the recommendations of the International Commission on Radiologic Protection, the radioelements are classified according to the danger that can occur from them in comparison with the Pu with regard to: - radioactive noxiousness; specific activity per unit of mass; contamination hazards. 4. The service in charge of radiation protection plays the important part of a technical adviser for the construction of specialized laboratories and sees to the keeping of protection regulations. 5. Data essential to radiation protection are given to the people using radioactive materials; particularly: - a table of the radioisotopes and the hazards occurring from them; - radiation hazards regarding γ ray emitted by irradiated Pu; - radiation hazards regarding γ ray emitted by irradiated Th. 6. As the hazards occasioned by irradiated uranium have already been studied, the case of a low and total irradiation will only

  20. HANFORD CHEMICAL VAPORS WORKER CONCERNS & EXPOSURE EVALUATION

    Energy Technology Data Exchange (ETDEWEB)

    ANDERSON, T.J.

    2006-12-20

    Chemical vapor emissions from underground hazardous waste storage tanks on the Hanford site in eastern Washington State are a potential concern because workers enter the tank farms on a regular basis for waste retrievals, equipment maintenance, and surveillance. Tank farm contractors are in the process of retrieving all remaining waste from aging single-shell tanks, some of which date to World War II, and transferring it to newer double-shell tanks. During the waste retrieval process, tank farm workers are potentially exposed to fugitive chemical vapors that can escape from tank headspaces and other emission points. The tanks are known to hold more than 1,500 different species of chemicals, in addition to radionuclides. Exposure assessments have fully characterized the hazards from chemical vapors in half of the tank farms. Extensive sampling and analysis has been done to characterize the chemical properties of hazardous waste and to evaluate potential health hazards of vapors at the ground surface, where workers perform maintenance and waste transfer activities. Worker concerns. risk communication, and exposure assessment are discussed, including evaluation of the potential hazards of complex mixtures of chemical vapors. Concentrations of vapors above occupational exposure limits-(OEL) were detected only at exhaust stacks and passive breather filter outlets. Beyond five feet from the sources, vapors disperse rapidly. No vapors have been measured above 50% of their OELs more than five feet from the source. Vapor controls are focused on limited hazard zones around sources. Further evaluations of vapors include analysis of routes of exposure and thorough analysis of nuisance odors.

  1. The Death of the Concerned Intellectual?

    Directory of Open Access Journals (Sweden)

    Chongyi Feng

    2005-08-01

    Full Text Available This paper offers a definition of the intellectual covering both professional and moral dimensions: An intellectual is a specialist who creates and communicates symbolised knowledge as means of living, and hopefully intervenes in social and political affairs in the name of universal values, truth and justice. "Symbolised knowledge" is used in the definition to avoid the confusion with other forms of knowledge derived from direct personal experience in production and life. The purpose of using "specialist" as the subject term is to exclude those categories such politicians, soldiers and business people who exercise political, military, financial and other forms of power instead of intellectual power in their social function. This paper argues that there are many roles played by intellectuals, and the social location and function of intellectuals can be fundamentally different in different societies. When production and communication of knowledge are taken as the primary concern of intellectuals, ‘the death of the concerned intellectual’ becomes an unwarranted anxiety, because there is no reason to believe that knowledge and truth will no longer be pursued and valued by humankind. Political marginalisation of critical intellectuals, where it is a reality, seems to be caused not so much by the lack of power of intellectuals as by the lack of solidarity among intellectuals to fight for a common cause. The problem lies as much in the lack of enthusiasm among intellectuals to transcend the boundaries of their professional relevance and intervene in broad social and political issues, as in institutional structures consuming too much energy and time of the intellectuals and seducing them to give up their social responsibilities for personal career.

  2. Concerns in Marine Renewable Energy Projects

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Sharon; Previsic, Mirko; Nelson, Peter; Woo, Sheri

    2010-06-17

    To accelerate the adoption of these emerging marine hydrokinetic technologies, navigational and environmental issues and concerns must be identified and addressed. As hydrokinetic projects move forward, various stakeholders will need to be engaged; one of the key issues that project proponents face as they engage stakeholders is that many conflicting uses and environmental issues are not well-understood. Much of this lack of understanding comes from a limited understanding of the technologies themselves. To address this issue, in September 2008, RE Vision consulting, LLC, was selected by the Department of Energy, under their market acceleration program, to apply a scenario-based assessment approach to the emerging hydrokinetic technology sector. The goal was to improve understanding of potential environmental and navigation impacts of these technologies and focus stakeholders on the critical issues. To meet this goal, the study established baseline scenarios for wave and tidal power conversion at potential future deployment sites. The scenarios captured variations in technical approaches and deployment scales and thus grounded the analysis in realistic constraints. The work conducted under this award provides an important foundation to other market acceleration activities carried out by the DOE and other stakeholders in this sector. The scenarios were then evaluated using a framework developed by H.T. Harvey & Associates to identify and characterize key environmental concerns and uncertainties. In collaboration with PCCI and the U.S. Coast Guard, navigation issues were assessed and guidelines developed to assure the safe operation of these systems. Finally, the work highlights “next steps” to take to continue development and adoption of marine hydrokinetic energy. Throughout the project, close collaboration with device developers, project developers and regulatory stakeholders was pursued to ensure that assumptions and constraints are realistic. Results concur

  3. Appendix: Conjectures concerning proof, design, and verification.

    Energy Technology Data Exchange (ETDEWEB)

    Wos, L.

    2000-05-31

    This article focuses on an esoteric but practical use of automated reasoning that may indeed be new to many, especially those concerned primarily with verification of both hardware and software. Specifically, featured are a discussion and some methodology for taking an existing design -- of a circuit, a chip, a program, or the like--and refining and improving it in various ways. Although the methodology is general and does not require the use of a specific program, McCune's program OTTER does offer what is needed. OTTER has played and continues to play the key role in my research, and an interested person can gain access to this program in various ways, not the least of which is through the included CD-ROM in [3]. When success occurs, the result is a new design that may require fewer components, avoid the use of certain costly components, offer more reliability and ease of verification, and, perhaps most important, be more efficient in the contexts of speed and heat generation. Although the author has minimal experience in circuit design, circuit validation, program synthesis, program verification, and similar concerns, (at the encouragement of colleagues based on successes to be cited) he presents materials that might indeed be of substantial interest to manufacturers and programmers. He writes this article in part prompted by the recent activities of chip designers that include Intel and AMD, activities heavily emphasizing the proving of theorems. As for his research that appears to the author to be relevant, he has made an intense and most profitable study of finding proofs that are shorter [2,3], some that avoid the use of various types of term, some that are far less complex than previously known, and the like. Those results suggest to me a strong possible connection between more appealing proofs (in mathematics and in logic) and enhanced and improved design of both hardware and software. Here the author explores diverse conjectures that elucidate some of

  4. Study of analytical methods concerning storage effect of underground dam

    Energy Technology Data Exchange (ETDEWEB)

    Hirama, Kunioki; Kuwahara, Toru; Kushima, Masatoshi (Obayashi Corp., Osaka, (Japan))

    1989-08-10

    Information on water balance concerning a catchment area of an underground dam is necessary for effective survey, design, construction and maintenance of the underground dam. Since the observation data of the underground water for about 5 years at some underground dam was obtained this time, they were used for evaluation of the storage effect of the underground dam by using the following four analytical methods, namely water balance equation, combination of tank model and water balance equation, numerical calculation by finite element method and hybrid model of finite element method and tank model. As a result, in case when permeable layers consist of sand and conglomerate of an alluvial system, it was found that evaluation of the storage at the underground dam and its characteristics was feasible and the following points were important for such evaluation; accumulation of observation data over a certain long period, correct information on hydrogeology, suitable composition of tank model, preparation of reasonable numerical model, and combination of analyses such as hybridization of tank models, etc.. 6 refs., 8 figs., 4 tabs.

  5. Regulations concerning liability, financial security, and the financing of decommissioning

    International Nuclear Information System (INIS)

    It is self-evident that any sensible reform in the area of liability has to work from the concern for the protection of the injured parties. After the introduction of unlimited liability in 1985 the only remaining starting point for improving the position of an assumed injured partly is that of provision of funds. In view of the responsibility of the respective consative parties for the spheres concerned it is the task of the state and the industry to raise sufficient provision funds to meet the requirements for the protection of the injured parties. Prompted by the existence of corresponding models in foreign legal systems, decommissioning provisions have been discovered as a new field of atomic energy law requiring regularization. Model considerations on how to improve decommissioning provisions show that legislative action is not required to achieve the desired aim. Financial provisions are regularizable solely on the basis of the law in force. Changes are required neither in atomic energy law nor in commercial law nor in tax law. (orig./HSCH)

  6. Energy, economy and development (EED) triangle: Concerns for India

    Energy Technology Data Exchange (ETDEWEB)

    Chaturvedi, A. [Department of Energy, Tezpur University, Tezpur 784028, Assam (India); Samdarshi, S.K., E-mail: drsksamdarshi@rediffmail.com [Department of Energy, Tezpur University, Tezpur 784028, Assam (India)

    2011-08-15

    In this paper we discuss issues involving energy security with economic growth and development that brings out (i) the dimension of physical security alternative, (ii) framework for a pan South East Asian platform to support energy security and (iii) requirement of promoting regional energy cooperation and specific energy peace initiatives. Sustaining projected economic growth rate coupled with energy security in future is a concern for all developing countries like India. The energy security of these nations is threatened by the disruption of energy supplies by ongoing energy terrorism and geopolitical conflicts in the region. India's geo-strategic position and increasing energy dependence raises concerns for its energy security. We discuss energy security, examine factors and approaches to attempt the energy security in the light of economic growth and development. - Highlights: > India's perspective on evolving energy security concepts and risks analysed. > Model in the form of EED triangle proposed. > New potential energy security alternatives proposed in the light of the model.

  7. Energy, economy and development (EED) triangle: Concerns for India

    International Nuclear Information System (INIS)

    In this paper we discuss issues involving energy security with economic growth and development that brings out (i) the dimension of physical security alternative, (ii) framework for a pan South East Asian platform to support energy security and (iii) requirement of promoting regional energy cooperation and specific energy peace initiatives. Sustaining projected economic growth rate coupled with energy security in future is a concern for all developing countries like India. The energy security of these nations is threatened by the disruption of energy supplies by ongoing energy terrorism and geopolitical conflicts in the region. India's geo-strategic position and increasing energy dependence raises concerns for its energy security. We discuss energy security, examine factors and approaches to attempt the energy security in the light of economic growth and development. - Highlights: → India's perspective on evolving energy security concepts and risks analysed. → Model in the form of EED triangle proposed. → New potential energy security alternatives proposed in the light of the model.

  8. Concerning the justiciability of demand forecasts

    International Nuclear Information System (INIS)

    This subject plays at present in particular a role in the course of judicial examinations of immediately enforceable orders for the partial construction licences of nuclear power plants. The author distinguishes beween three kinds of forecast decisions: 1. Appraising forecast decisions with standards of judgment taken mainly from the fields of the art, culture, morality, religion are, according to the author, only legally verifyable to a limited extent. 2. With regard to forecast decisions not arguable, e.g. where the future behaviour of persons is concerned, the same should be applied basically. 3. In contrast to this, the following is applicable for programmatic, proceedingslike, or creative forecast decisions, in particular in economics: 'An administrative estimation privilege in a prognostic sense with the consequence that the court has to accept the forecast decision which lies within the forecast margins and which cannot be disproved, and that the court may not replace this forecast decision by its own probability judgment. In these cases, administration has the right to create its own forecast standards.' Judicial control in these cases was limited to certain substantive and procedural mistakes made by the administration in the course of forecast decision finding. (orig./HP)

  9. Message concerning Severe Acute Respiratory Syndrome ("SARS")

    CERN Multimedia

    2003-01-01

    IMPORTANT REMINDER If you have just come back from one of the regions identified by the WHO as being infected with SARS, it is essential to monitor your state of health for ten days after your return. The syndrome manifests itself in the rapid onset of a high fever combined with respiratory problems (coughing, breathlessness, breathing difficulty). Should these signs appear, you must contact the CERN Medical Service as quickly as possible on number 73802 or 73186 during normal working hours, and the fire brigade at all other times on number 74444, indicating that you have just returned from one of the WHO-identified areas with recent local transmission.China: Beijing, Hong Kong (Special Administrative Region), Guangdong Province, Inner Mongolia, Shanxi Province, Tianjin ProvinceTaiwan:TaipeiMoreover, until further notice the CERN Management requests that all trips to these various regions of the world be reduced to a strict minimum and then only with the consent of the Division Leader concerned. Anyone comin...

  10. Leishmaniasis, a global concern for travel medicine.

    Science.gov (United States)

    Neghina, Raul; Neghina, Adriana M

    2010-08-01

    Leishmaniasis, a parasitic infection listed by the World Health Organization among the 6 most important tropical diseases, is endemic in approximately 88 countries worldwide, with a global estimate of 350 million individuals at risk. The present report aims to review the imported cases of leishmaniasis reported in retrospective studies or described as clusters or single interesting cases. It is apparent that some European countries considered as premier tourist attractions export leishmaniasis: Greece, France, Italy, Spain, Portugal, Croatia and Turkey. Travelling and exploring the New World countries, especially the Amazonian jungle and the archaeological ancient sites, is a continuous challenge, with a risk of acquiring various tropical infections. Imported leishmaniasis has occurred in individuals who have gone to work abroad in improper conditions, without being aware of the risk of severe vector-borne infections. Exported cases are carried by refugees and immigrants from endemic developing countries. Extended military operations are a further source of imported cases. In the new millennium, the import and export of leishmaniasis continue to be of major concern for public health services worldwide as a result of increased mobility. PMID:20438287

  11. Wireless Network Security Vulnerabilities and Concerns

    Science.gov (United States)

    Mushtaq, Ahmad

    The dilemma of cyber communications insecurity has existed all the times since the beginning of the network communications. The problems and concerns of unauthorized access and hacking has existed form the time of introduction of world wide web communication and Internet's expansion for popular use in 1990s, and has remained till present time as one of the most important issues. The wireless network security is no exception. Serious and continuous efforts of investigation, research and development has been going on for the last several decades to achieve the goal of provision of 100 percent or full proof security for all the protocols of networking architectures including the wireless networking. Some very reliable and robust strategies have been developed and deployed which has made network communications more and more secure. However, the most desired goal of complete security has yet to see the light of the day. The latest Cyber War scenario, reported in the media of intrusion and hacking of each other's defense and secret agencies between the two super powers USA and China has further aggravated the situation. This sort of intrusion by hackers between other countries such as India and Pakistan, Israel and Middle East countries has also been going on and reported in the media frequently. The paper reviews and critically examines the strategies already in place, for wired network. Wireless Network Security and also suggests some directions and strategies for more robust aspects to be researched and deployed.

  12. Ubiquitous Health Monitoring Systems: Addressing Security Concerns

    Directory of Open Access Journals (Sweden)

    Mahmoud Elkhodr

    2011-01-01

    Full Text Available Problem statement: It is important to secure the transmission of patient’s EHR in remote health monitoring systems. Security is among the main issues that need to be realized for the adaption of this monitoring technology. The face of healthcare is changing as ubiquitous computing technologies are being incorporated into the existing infrastructure. We specify the requirements, needed security mechanism, outstanding issues and the future challenges as well as the open problems that need to be achieved. Approach: Although there were benefits to technology, approaches that offer reliable privacy and security features must be presented to users in order to make these systems socially accepted. Results: We investigated the privacy and security implications generated from the deployment of remote health monitoring technology. To achieve these security requirements, building on the strengths of Transport Layer Security (TLS protocol, a trust negotiation approach was proposed. The application of this approach results in significant improvements in overcoming security related concerns compared to the traditional identity-based only access control techniques. Conclusion: We believe these considerations will eventually contribute toward an efficient and practical deployment of remote monitoring systems.

  13. Perspectives of a concerned developing country

    International Nuclear Information System (INIS)

    We convene today against a backdrop of disturbing developments that have taken place in the field of nuclear disarmament and non-proliferation over the past 15 years. Every nation on Earth holds high stakes in the promotion of these twin goals; however, whichever way we choose to set our sights, we find today that confidence is eroding in the process agreed upon and generally entrusted with fostering those objectives for four decades. The views I would like to convey to you are therefore not exclusively those of a developing country. For all our countries are at various stages in the development process of peaceful nuclear applications, especially as concerns the production of energy for a post-Kyoto world. On the issue relating to nuclear material reaching unauthorized actors, we should do our utmost in order to prevent theft or the unaccountability of radioactive material. Having said that, I am not convinced that non-State actors can on their own develop nuclear weapons or any other explosive nuclear device without the help of a State. The question therefore is one of ensuring that security measures are effective and implementable. I leave it to others more knowledgeable than myself to dwell on this issue during the forthcoming days of this conference

  14. Citizenship education in discussions concerning political issues

    Directory of Open Access Journals (Sweden)

    Johan Liljestrand

    2012-01-01

    Full Text Available The purpose of this article is to analyse the International Civic and Citizenship Education Study (ICCS use of discussions on social and political issues and then problematize the meaning of “discussions” – in particular, the topic of discussion – through a qualitative analysis of actual discussions in the classroom. A qualitative study of classroom discussions is used to shed light on everyday preconditions between teacher and students. The topic of discussion,is analysed as a social and discursive construction. Political matters such as institutional issues and (international affairs in the ICCS-study are also mostly the focus for the teachers in the classroom study. However, the interaction between teachers and students would seem to indicate that choice of issues for discussion always is a political choice. If students are imagined througha lens of being citizens, already in school, then choice of issues for discussion could be understood as a process of negotiation between the teacher and the students. The issues for discussion can therefore be connected to a notion of legitimate democratic participation concerning mutually recognized issues.

  15. Resolving issues concerning Eskdalemuir geomagnetic hourly values

    Directory of Open Access Journals (Sweden)

    S. Macmillan

    2011-02-01

    Full Text Available The hourly values of the geomagnetic field from 1911 to 1931 derived from measurements made at Eskdalemuir observatory in the UK, and available online from the World Data Centre for Geomagnetism at http://www.wdc.bgs.ac.uk/, have now been corrected. Previously they were 2-point averaged and transformed from the original north, east and vertical down values in the tables in the observatory yearbooks. This paper documents the course of events from discovering the post-processing done to the data to the final resolution of the problem. As it was through the development of a new index, the Inter-Hour Variability index, that this post-processing came to light, we provide a revised series of this index for Eskdalemuir and compare it with that from another European observatory. Conclusions of studies concerning long-term magnetic field variability and inferred solar variability, whilst not necessarily consistent with one another, are not obviously invalidated by the incorrect hourly values from Eskdalemuir. This series of events illustrates the challenges that lie ahead in removing any remaining errors and inconsistencies in the data holdings of different World Data Centres.

  16. Female feticide in India: Issues and concerns

    Directory of Open Access Journals (Sweden)

    Garg S

    2008-01-01

    Full Text Available The preference for a son continues to be a prevalent norm in the traditional Indian household. This is evident from the declining sex ratio which has dropped to alarming levels, especially in the northern states according to Census 2001 reports. The proliferation and abuse of advanced technologies coupled with social factors contributing to the low status of women such as dowry, concerns with family name and looking up to the son as a breadwinner has made the evil practice of female feticide to become common in the middle and higher socioeconomic households, especially in the northern states. Despite the existence of the Prenatal Diagnostic Techniques Act, there is a dire need to strengthen this law since the number of convictions is despairingly low as compared to the burden posed by this crime. Moreover, it is necessary to gear efforts against the cultural, economic and religious roots of this social malady by woman empowerment and intensive Information, Education and Communication campaigns. The medical colleges and professional bodies have a vital role to play by sensitizing medical students who are the doctors of tomorrow.

  17. [Tissue grafts: an activity concerning many patients].

    Science.gov (United States)

    Loty, B

    1997-11-15

    Tissue allografts mainly include corneas, bone (and cartilage, tendon, ligament, aponevrosis), skin, vessels and cardiac valves. All these grafts have been widely used for many years and were the subject of a large number of experimental and clinical studies. The different steps allowing the obtention of different tissue allografts have in fact a common organization through tissue procurement and banking activities. Tissue banks have a central situation ensuring security, safety, traceability and distribution of tissues. Appropriate organization of the banks, and respect of high level standards are thus mandatory. Tissue transplantation activity in France has been studied through national surveys: they concern more than 600 hospitals and clinics, and grafts procured in France (excluding imported allografts) are around 15,000 a year. Precise regulation implied by the bioethical law published in 1994 and homogeneous organization of the activity allow the use of stringent and regularly updated standards, allowing the distribution to the patients of safe grafts procured in ethical conditions. The actual shortage of tissue allografts in France implies increasing procurement through a better organization of retrieval in hospitals and clinics and donation promotion. PMID:9501596

  18. Human health concerns with GM crops.

    Science.gov (United States)

    Malarkey, Trish

    2003-11-01

    Biotechnology was used in the first generation of so-called 'GM' crops to provide growers with complimentary and sometimes alternative crop management solutions to pesticides. Selected host genes or genes identified from other plants or non-plant sources are modified or transferred to a crop plant. The new or altered protein expression resulting from these modifications confer on the plant a desired physiological trait, such as resistance to particular herbicides or insect pests. Second generation modifications provide traits such as enhanced nutritional or health-promoting characteristics that are of benefit to consumers. The commonly raised concerns about possible implications for human health are: inherent toxicity of the novel gene and their products, the potential to express novel antigenic proteins or alter levels of existing protein allergens, the potential for unintended effects resulting from alterations of host metabolic pathways or over expression of inherently toxic or pharmacologically active substances and the potential for nutrient composition in the new food occur differing significantly from a conventional counterpart. Foods produced using biotechnology are subjected to far greater levels of scrutiny than foods produced by traditional plant breeding techniques. The accepted analytical, nutritional and toxicological methods employed to support this scrutiny and to assess and assure that a 'GM' food is a safe and nutritious as its 'non-GM' counterpart are discussed. The challenges associated with identifying unintended effects in whole GM foods and the promise new (proteomics/genomic) technologies offer opposite traditional toxicity testing paradigms are appraised. PMID:14644323

  19. Benchmarketing - Fashionable Term Concerning Traditional Processes

    Directory of Open Access Journals (Sweden)

    Mircea Udrescu

    2016-06-01

    Full Text Available Marketing is a major factor to boost the competitiveness of the firm in an environment which is more and more turbulent. It centers the company’s management as being the ideal satisfaction of the current and potential consumer. This is why, in our conception, the marketing’s management represents a subsystem of the company’s’ general management by which shall be administered to specific activities, and also designed to contour the company’s’ activity object. In this article, the intent is to highlight the fact that the benchmarketing has come loose from cultivating the traditional process to the innovative organizational culture product. In this paper, the authors consider benchmarketing as a process of qualitative organizational culture adaptation to market requirements, depending on the context, so as to ensure the improvement of the economic criteria of appreciation of the business lucrative activities. Based on direct observations concerning small firms, followed by analysis, comparison and synthesis, the authors suggest taking into consideration the theoretical and practical benchmarketings’ approach, as being the current strategy of acquiring and cultivating excellence, as initiation philosophy and business development.

  20. Recent concerns about stunning and slaughter.

    Science.gov (United States)

    Gregory, N G

    2005-07-01

    This review summarises information that is relevant to concerns that have recently been expressed about stunning and slaughter. It is known that captive bolt stunning can result in brain material passing to the lungs via the jugular veins. If future studies show that BSE prions pass beyond the lungs to the edible carcass, there will be a move away from captive bolt stunning in large cattle towards electrical stunning. Greater use of electrical stunning in large cattle will increase the importance of blood splash in the beef industry. The theoretical causes of blood splash are reviewed to improve our understanding of this problem. In some situations it can be due to excessive venous pressure causing rupture of a capillary bed some distance from the source of the pressure rise, but it is not known whether this applies to electrical stunning. Gas stunning is replacing electrical stunning for poultry because it can reduce blood spots, which is a similar condition to blood splash. Several gas stunning methods are now being used, but it is not clear which of these is the most humane. Anoxic stunning leads to carcass convulsions and this causes more carcass damage. In fish, recent developments in electrical stunning are showing promise in overcoming problems with carcass damage. It is recommended that rock lobsters should be chilled or frozen before butchery, to ensure a humane death. PMID:22063747

  1. 48 CFR 752.219-8 - Utilization of small business concerns and small disadvantaged business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Utilization of small... AND CONTRACT CLAUSES Texts of Provisions and Clauses 752.219-8 Utilization of small business concerns..., provide the following information to the Office of Small and Disadvantaged Business Utilization...

  2. PENGARUH PENERBITAN OPINI GOING CONCERN PADA PERGANTIAN AUDITOR PADA PERUSAHAAN YANG TERDAFTAR PADA BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Made Wahyu Adhiputra

    2015-10-01

    Full Text Available Tujuan penelitian ini adalah untuk membuktikan secara empiris pengaruh opini going concern pada pergantian auditor, kemampuan ketepatwaktuan pelaporan keuangan dan komite audit memoderasi pengaruh opini going concern pada pergantian auditor, dan pengaruh interaksi opini going concern, ketepatwaktuan pelaporan keuangan, dan komite audit pada pergantian auditor. Populasi yang digunakan dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia tahun 2011-2013 dengan metode pemilihan sampel menggunakan purposive sampling. Pengujian hipotesis dilakukan dengan menggunakan regresi logistik binari dengan dua model penelitian. Hasil penelitian menunjukkan penerbitan opini going concern berpengaruh positif pada kemungkinan terjadinya pergantian auditor. Ketepatwaktuan pelaporan keuangan dan komite audit tidak memoderasi pengaruh penerbitan opini going concern pada kemungkinan terjadinya pergantian auditor. Hasil penelitian juga menunjukkan interaksi penerbitan opini going concern, ketepatwaktuan pelaporan keuangan dan komite audit tidak berpengaruh pada kemungkinan perusahaan melakukan pergantian auditor.The purpose of this study are to determine the effect of going concern opinion at the auditor switching, to determine the ability of timeliness of financial reporting and the audit committee to moderate the effect of going concern opinion at the auditor switching, and to determine the effect of the interaction of the going concern opinion, timeliness of financial reporting and the audit committee at the auditor switching. The population used in this study are all companies listed on the Indonesia Stock Exchange in 2011-2013 with selection method sample using purposive sampling. Hypothesis testing is performed using binary logistic regression. The results showed the issuance of going concern opinion has a positive effect on the possibility of auditor switching. Timeliness of financial reporting and the audit committee did not

  3. Cholera:a great global concern

    Institute of Scientific and Technical Information of China (English)

    Shyamapada Mandal; Manisha Deb Mandal; Nishith Kumar Pal

    2011-01-01

    Cholera, caused by the infection of toxigenicVibrio cholerae (V. cholerae)to humans, is a life threatening diarrheal disease with epidemic and pandemic potential. TheV. cholerae, both O1 and O139 serogroups, produce a potent enterotoxin (cholera toxin) responsible for the lethal symptoms of the disease. TheO1 serogroup has two biotypes (phenotypes), classical and El Tor; each of which has two major serotypes (based on antigenic responses), Ogawa and Inaba and the extremely rare Hikojima.V. choleraeO1 strains interconvert and switch between the Ogawa and Inaba serotypes. Fluid and electrolyte replacement is the mainstay of treatment of cholera patients; the severe cases require antibiotic treatment to reduce the duration of illness and replacement of fluid intake. The antibiotic therapy currently has faced difficulties due to the rapid emergence and spread of multidrug resistantV. cholerae causing several outbreaks in the globe. Currently, cholera has been becoming endemic in an increasing number of geographical areas, reflecting a failure in implementation of control measures. However, the current safe oral vaccines lower the number of resistant infections and could thus represent an effective intervention measure to control antibiotic resistance in cholera. Overall, the priorities for cholera control remain public health interventions through improved drinking water, sanitation, surveillance and access to health care facilities, and further development of safe, effective and appropriate vaccines. Thus, this review describes the facts and phenomena related to the disease cholera, which is still a great threat mainly to the developing countries, and hence a grave global concern too.

  4. Polymyxins: Antimicrobial susceptibility concerns and therapeutic options

    Directory of Open Access Journals (Sweden)

    V Balaji

    2011-01-01

    Full Text Available The increasing prevalence of multidrug-resistant nosocomial pathogens such as Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae poses a great challenge to the treating physicians. The paucity of newer effective antimicrobials has led to renewed interest in the polymyxin group of drugs, as a last resort for treatment of gram-negative bacterial infections. There is a dearth of information on the pharmacological properties of colistin, leading to difficulties in selecting the right dose, dosing interval, and route of administration for treatment, especially in critically-ill patients. The increasing use of colistin over the last few years necessitates the need for accurate and reliable in vitro susceptibility testing methods. Development of heteroresistant strains as a result of colistin monotherapy is also a growing concern. There is a compelling need from the clinicians to provide options for probable and possible colistin combination therapy for multidrug-resistant bacterial infections in the ICU setting. Newer combination drug synergy determination tests are being developed and reported. There are no standardized recommendations from antimicrobial susceptibility testing reference agencies for the testing and interpretation of these drug combinations. Comparison and analysis of these reported methodologies may help to understand and assist the microbiologist to choose the best method that produces accurate results at the earliest. This will help clinicians to select the appropriate combination therapy. In this era of multidrug resistance it is important for the microbiology laboratory to be prepared, by default, to provide timely synergistic susceptibility results in addition to routine susceptibility, if warranted. Not as a favour or at request, but as a responsibility.

  5. Nuclear education and training: cause for concern?

    International Nuclear Information System (INIS)

    Nuclear power plants have played an important role in electricity generation in the OECD member countries, contributing an average 24% over the past few years. One major criterion for the success of this technology has always been the education and training of competent personnel in all sectors of nuclear development and application. The high level of competence and know-how reached must be maintained in the future. Qualified personnel is required for running existing plants, building new nuclear power plants - at present especially in Japan and Korea - and for all activities associated with supply and waste management, decommissioning, and for all applications of nuclear technology above and beyond energy generation. The number of university graduates in the OECD countries is decreasing alarmingly, among other reasons because of the diminished attractiveness of these courses as a consequence of the reduced number of nuclear engineering courses offered in curricula. A broad-based program of disseminating basic information in nuclear technology in university curricula is urgently required. In industry, internal advanced and in-career training measures and programs are offered to ensure broad-based qualification as well as specialization in nuclear subjects of the staff, as demands are rising and flexibility is required of all staff members. This development implies that governments in particular are called upon to ensure, by long-term planning, that nuclear competence is preserved in science and research, in industry and applications, as part of their areas of responsibility and competence. Note: The full text of the study on which this contribution is based has been published under the title of 'Nuclear Education and Training: Cause for Concern?' by OECD-NEA, Paris, 2000, 124 pages. (orig.)

  6. Research and Development Concerning Coalbed Natural Gas

    Energy Technology Data Exchange (ETDEWEB)

    William Ruckelshaus

    2008-09-30

    The Powder River Basin in northeastern Wyoming is one of the most active areas of coalbed natural gas (CBNG) development in the western United States. This resource provides clean energy but raises environmental concerns. Primary among these is the disposal of water that is co-produced with the gas during depressurization of the coal seam. Beginning with a few producing wells in Wyoming's Powder River Basin (PRB) in 1987, CBNG well numbers in this area increased to over 13,600 in 2004, with projected growth to 20,900 producing wells in the PRB by 2010. CBNG development is continuing apace since 2004, and CBNG is now being produced or evaluated in four other Wyoming coal basins in addition to the PRB, with roughly 3500-4000 new CBNG wells permitted statewide each year since 2004. This is clearly a very valuable source of clean fuel for the nation, and for Wyoming the economic benefits are substantial. For instance, in 2003 alone the total value of Wyoming CBNG production was about $1.5 billion, with tax and royalty income of about $90 million to counties, $140 million to the state, and $27 million to the federal government. In Wyoming, cumulative CBNG water production from 1987 through December 2004 was just over 380,000 acre-feet (2.9 billion barrels), while producing almost 1.5 trillion cubic feet (tcf) of CBNG gas statewide. Annual Wyoming CBNG water production in 2003 was 74,457 acre-feet (577 million barrels). Total production of CBNG water across all Wyoming coal fields could total roughly 7 million acre-feet (55.5 billion barrels), if all of the recoverable CBNG in the projected reserves of 31.7 tcf were produced over the coming decades. Pumping water from coals to produce CBNG has been designated a beneficial water use by the Wyoming State Engineer's Office (SEO), though recently the SEO has limited this beneficial use designation by requiring a certain gas/water production ratio. In the eastern part of the PRB where CBNG water is generally of good

  7. On Julia sets concerning phase transitions

    Institute of Scientific and Technical Information of China (English)

    QIAO; Jianyong(乔建永)

    2003-01-01

    The sets of the points corresponding to the phase transitions of the Potts model on the diamondhierarchical lattice for antiferromagnetic coupling are studied. These sets are the Julia sets of a family ofrational mappings. It is shown that they may be disconnected sets. Furthermore, the topological structures ofthese sets are described completely.

  8. Food safety concerns of fast food consumers in urban Ghana.

    Science.gov (United States)

    Omari, Rose; Frempong, Godfred

    2016-03-01

    In Ghana, out-of-home ready-to-eat foods including fast food generally have been associated with food safety problems. Notwithstanding, fast food production and consumption are increasing in Ghana and therefore this study sought to determine the food safety issues of importance to consumers and the extent to which they worry about them. First, through three focus group discussions on consumers' personal opinions about food safety issues, some emergent themes were obtained, which were used to construct an open-ended questionnaire administered face-to-face to 425 respondents systematically sampled from 20 fast food restaurants in Accra. Findings showed that most fast food consumers were concerned about food hazards such as pesticide residue in vegetables, excessive use of artificial flavour enhancers and colouring substances, bacterial contamination, migrated harmful substances from plastic packages, and general unhygienic conditions under which food is prepared and sold. Consumers also raised concerns about foodborne diseases such as cholera, typhoid, food poisoning, diarrhoea, bird flu and swine flu. The logistic regression model showed that being male increased the likelihood of worrying about general food safety issues and excessive use of flavour enhancers than in females while being youthful increased the likelihood of being worried about typhoid fever than in older consumers. These findings imply that consumers in urban Ghana are aware and concerned about current trends of food safety and foodborne disease challenges in the country. Therefore, efforts targeted at improving food safety and reducing incidences of foodborne diseases should not only focus on public awareness creation but should also design more comprehensive programmes to ensure the making of food safety rules and guidelines and enforcing compliance to facilitate availability and consumers' choice of safe foods. PMID:26686975

  9. Malaysia's contributions towards global climate change concerns

    International Nuclear Information System (INIS)

    Concerns about Green House Gas (GHG) emissions and global climate change were voiced by the scientific community as far back as the International Geophysical year in 1957 when climate changes scenarios and impacts were analysed. More recently, the United Nations Framework Convention on climate change (UNFCCC) was adopted in 1992, renewing a global acknowledgement and commitment towards curbing GHG emissions. Little progress was made until the adoption of Kyoto Protocol in December 1997, over 5 years later. Basically, developed countries would not commit to strong measures if there were no global effort (i. e. corresponding efforts by developing countries) while developing countries are waiting for developed countries to show concrete results first. Since 1950, developed countries cumulatively produced more than 80% of worldwide GHG emissions. Between 1950 and 1990, North America alone contributed 40 billion tons of carbon while Western and Eastern Europe contributed 57 billion tons. Developing countries produced only 24 billion tons of carbon emissions during the same period. At present, per capita emission in developed countries are also about ten times higher than those of developing countries. This imbalance has caused most developing countries to adopt a wait till others do it stance and justifiably so. Nonetheless, curbing GHG emissions should be a larger community effort (which includes business and the public) and not just the efforts of Governments and officials. Thus, the deciding factors should make more business or economic sense. It is likely that business and the general public would listen and contribute positively if they are made aware of potential cost savings and international competitiveness to be derived from these efforts. During the current economic slowdown, especially in East Asia, it makes business sense to defer the capital investment in new electricity generating capacity and related energy supply infrastructure. Pusat Tenaga Malaysia

  10. Some issues concerning holographic dark energy

    International Nuclear Information System (INIS)

    We study the perturbation of holographic dark energy and find it to be stable. We study the fate of the universe when interacting holographic dark energy is present, and discuss a simple phenomenological classification of the interacting holographic dark energy models. We also discuss the cosmic coincidence problem in the context of holographic dark energy. We find that the coincidence problem cannot be completely solved by adding an interacting term. Inflation may provide a better solution of the coincidence problem

  11. Some Issues Concerning Holographic Dark Energy

    OpenAIRE

    Li, Miao; Lin, Chunshan; Wang, Yi

    2008-01-01

    We study perturbation of holographic dark energy and find it be stable. We study the fate of the universe when interacting holographic dark energy is present, and discuss a simple phenomenological classification of the interacting holographic dark energy models. We also discuss the cosmic coincidence problem in the context of holographic dark energy. We find that the coincidence problem can not be completely solved by adding an interacting term. Inflation may provide a better solution of the ...

  12. Sustainable Development as Concern for Industrial Companies

    DEFF Research Database (Denmark)

    Bundgaard, Hans

    Today, the industrial company has responsibilities towards the environment, the society, and the owners. From a theoretical base of social theory and social science, this industry research has considered the preconditions for a more proactive industrial response towards sustainability. A new...... conceptual model for management approach to the environmental dimension, and corporate environmental management initiated intervention, changing management conception and organisational capability to live up to future environment-related responsibilities and business opportunities in soiciety, is suggested....

  13. Nuisance Odors: Is there a Concern - 12340

    Energy Technology Data Exchange (ETDEWEB)

    Brounstein, Robert A. [TerranearPMC, Los Alamos New Mexico 87544 (United States)

    2012-07-01

    Nuisance odors are generally thought of as just being annoying or unpleasant and not causing any physiological harm to our internal organs or other biologic systems. Yet during an excavation of buried animal remains, field workers experienced a multitude of symptoms that are associated with exposures to toxic materials. An examination of the decomposition process revealed that there is a potential off-gassing of a number of common, yet harmful chemicals including ammonia, mercaptans, hydrogen sulfide, butyric acid and phenol. In addition, other compounds, that have limited information such as established health data and occupational exposure limits, were also potential contaminants-of-concern. While a variety of monitoring and sampling techniques were used to assess worker exposures, all results indicated non-detectable airborne concentrations. Nevertheless, workers were experiencing such symptoms as nausea and headaches. As such, protective measures were necessary for field personnel to continue work while having confidence that the project was instituting sincere steps to ensure their health and safety. Researching the possible reasons for the causes of workers exhibiting adverse health effects from nuisance odors revealed that such exposures initiate electrochemical pathways, starting from the olfactory bulb to the brain, followed by a transfer of information to such biologic systems as the hypothalamus and pituitary gland. These systems, in turn, secrete hormones that cause a number of involuntary reactions; many of which are observed as typical adverse health effects, when in fact, they are merely reactions caused by the brain's memory; most likely created from previous experiences to unpleasant odors. The concern then focuses of how the Occupational Safety and Health community shall respond to such workplace exposures. Future work in this area may need to focus on the viability of current occupational exposure limits and the possibility of revising these

  14. Nuisance Odors: Is there a Concern - 12340

    International Nuclear Information System (INIS)

    Nuisance odors are generally thought of as just being annoying or unpleasant and not causing any physiological harm to our internal organs or other biologic systems. Yet during an excavation of buried animal remains, field workers experienced a multitude of symptoms that are associated with exposures to toxic materials. An examination of the decomposition process revealed that there is a potential off-gassing of a number of common, yet harmful chemicals including ammonia, mercaptans, hydrogen sulfide, butyric acid and phenol. In addition, other compounds, that have limited information such as established health data and occupational exposure limits, were also potential contaminants-of-concern. While a variety of monitoring and sampling techniques were used to assess worker exposures, all results indicated non-detectable airborne concentrations. Nevertheless, workers were experiencing such symptoms as nausea and headaches. As such, protective measures were necessary for field personnel to continue work while having confidence that the project was instituting sincere steps to ensure their health and safety. Researching the possible reasons for the causes of workers exhibiting adverse health effects from nuisance odors revealed that such exposures initiate electrochemical pathways, starting from the olfactory bulb to the brain, followed by a transfer of information to such biologic systems as the hypothalamus and pituitary gland. These systems, in turn, secrete hormones that cause a number of involuntary reactions; many of which are observed as typical adverse health effects, when in fact, they are merely reactions caused by the brain's memory; most likely created from previous experiences to unpleasant odors. The concern then focuses of how the Occupational Safety and Health community shall respond to such workplace exposures. Future work in this area may need to focus on the viability of current occupational exposure limits and the possibility of revising these

  15. A few problems concerning population science.

    Science.gov (United States)

    Xu, D

    1981-05-27

    This paper discusses problems concerning population science in China within a Marxist perspective. In contrast to capitalism, the socialist society is built on the foundation of the socialist public ownership of the means of production. The socialist law of population, as distinct from the capitalist, means the inevitability of population planning under the socialist mode of production. If rapid population growth is allowed to continue, the yearly increment of material wealth will be conserved by the additional population which will thereby nullify the cultural and material needs of the people. Therefore, population growth planning is necessary to control reproduction and material production as well as the development of the national economy. 3 differences between Chinese population theory and that of the neoMalthusians are discussed: 1) whereas the neoMalthusians propose to safeguard the capitalist system, the Chinese theory is to consolidate the socialist system, 2) Malthusianism emphasizes population growth and ignores, unlike the Chinese system, the possibility of increasing production while achieving population control by degrees, and 3) responsibility for controlling "surplus population" is placed on the working people by neoMalthusians but on the elites in the Chinese system. Recent efforts in China are to control the population by reducing families to one child. In the past 30 years, a series of contradictions have developed in the development of the economy in relation to population growth: 1) distinct disproportion arises between the growth of the total population (66.7% between 1952-78) and that of the means of subsistence (5.4%/year between 1952-78); 2) if population growth is not controlled, a contradiction will occur between those of working ages and the growth of the means of production; and 3) the disproportion between the quality of population and the needs of the modern socialist system. Under the socialist system, population control is

  16. Overconfidence in a Career-Concerns Setting

    DEFF Research Database (Denmark)

    de la Rosa, Leonidas Enrique

    2008-01-01

    public signal. An overconfident agent believes that the principal will update her beliefs upwards more often than not. As a consequence, the agent overestimates the benefits of learning from first-period investment. This implies that agent overconfidence mitigates the agency problems arising from the......We study the effects of overconfidence in a two-period investment-decision agency setting. Under common priors, agent risk aversion implies inefficiently low first-period investment. In our model, principal and agent disagree about the profitability of the investment decision conditional on a given...

  17. Perspectives on Spatial Decision Support Concerning Location of Biogas Production

    DEFF Research Database (Denmark)

    Bojesen, Mikkel

    Biogas production is a contemporary important topic in many agri-intensive countries, among these Denmark, where biogas has received increasingly political and scholarly awareness during recent years. The Danish government has set an ambition that 50% of the livestock slurry should by 2020 by used...... in biogas production. This ambition requires that more than 20 new large scale centralised biogas plants are built. The location of these plants is associated with a number of externalities and uncertainties and the existing biogas sector struggles to establish itself as a viable energy producing...... sector. Meanwhile planners and decision makers struggle to find sustainable locations that comprehensively balance the multiple concerns the location of biogas facilities includes. This PhD project examines how spatial decision support models can be used to ensure sustainable locations of future biogas...

  18. Current Cloud Computing Security Concerns from Consumer Perspective

    Institute of Scientific and Technical Information of China (English)

    Hafiz Gulfam Ahmad; Zeeshan Ahmad

    2013-01-01

    In recent years cloud computing is the subject of extensive research in the emerging field of information technology and has become a promising business.The reason behind this widespread interest is its abilityto increase the capacity and capability of enterprises,having no investment for new infrastructure,no software license requirement and no need of any training. Security concern is the main limitation factor in the growth of this new born technology.The secur-ity responsibilities of both,the provider and the consumer greatly differ between cloud service models.In this paper we discuss a variety of security risks,authentication issues,trust,and legal regularity in cloud environment with consumer perspective.Early research focused only on techni-cal and business consequences of cloud computing and ignored consumer perspective.There-fore,this paper discusses the consumer security and privacy preferences.

  19. Behavioural controversy concerning homo economicus: a Humean perspective

    Directory of Open Access Journals (Sweden)

    Khandakar Elahi

    2014-05-01

    Full Text Available In his monumental masterpiece, A Treatise on Human Nature, which explains the methodology of human reasoning concerning matters of fact and describes the roles that passions and morals play in it, Hume arrives at an enormously interesting maxim: An academic controversy cannot continue for long unless the disputants assign different meanings to the major terms employed in the debate. This theory has been applied in this paper to examine the behavioural criticisms about Homo Economicus (HE, the pivotal perception in the neoclassical microeconomic model.To achieve this objective, the paper discusses the origin and evolution of the concept, reviews behavioural criticisms, summarises the main tenets of Hume’s philosophy of human knowledge and finally examines the behavioural opinions from Hume’s perspective. The paper concludes that Hume’s theory convincingly explains the reason why the HE controversy is continuing for over half century- a fact that both the mainstream and behavioural economists are ignoring.

  20. Helping the invisible hand: A theory of endogenous mutual concern

    OpenAIRE

    Kolmar, Martin

    2001-01-01

    This paper develops a theory of endogenous mutual concern. The mutual concern or the morality of economic agents is seen as a means to reduce the inefficiencies of markets in an environment where the enforcement of property rights is castly. We show that rational agents have an incentive to invest resources to create a mutual concern. Furthermore, the strength of the mutual concern depends on the technologies of production and appropriation and defense. People in economies with a high natural...

  1. Essays concerning the cellulosic biofuel industry

    Science.gov (United States)

    Rosburg, Alicia Sue

    Despite market-based incentives and mandated production, the U.S. cellulosic biofuel industry has been slow to develop. This dissertation explores the economic factors that have limited industry development along with important economic tradeoffs that will be encountered with commercial-scale production. The first essay provides an overview of the policies, potential, and challenges of the biofuel industry, with a focus on cellulosic biofuel. The second essay considers the economics of cellulosic biofuel production. Breakeven models of the local feedstock supply system and biofuel refining process are constructed to develop the Biofuel Breakeven (BioBreak) program, a stochastic, Excel-based program that evaluates the feasibility of local biofuel and biomass markets under various policy and market scenarios. An application of the BioBreak program is presented using expected market conditions for 14 local cellulosic biofuel markets that vary by feedstock and location. The economic costs of biofuel production identified from the BioBreak application are higher than frequently anticipated and raise questions about the potential of cellulosic ethanol as a sustainable and economical substitute for conventional fuels. Program results also are extended using life-cycle analysis to evaluate the cost of reducing GHG emissions by substituting cellulosic ethanol for conventional fuel. The third essay takes a closer look at the economic trade-offs within the biorefinery industry and feedstock production processes. A long-run biomass production through bioenergy conversion cost model is developed that incorporates heterogeneity of biomass suppliers within and between local markets. The model builds on previous literature by treating biomass as a non-commoditized feedstock and relaxes the common assumption of fixed biomass density and price within local markets. An empirical application is provided for switchgrass-based ethanol production within U.S. crop reporting districts

  2. A study on a systematic method for evaluating values of raised concerns

    International Nuclear Information System (INIS)

    The objective of this study is to develop a methodology that can externalise potential concerns and evaluate the values of the concerns raised in corporations. By implementing this methodology into corporate governance, it is expected to improve the work environment and enhance the capability for the corporate governance through supporting the internal autonomic purification. This study comprises of: case studies of past wrongdoings in corporations such as JCO and Tokyo Electric Power Company (TEPCO); identifying the viewpoints for evaluating values of raised concerns; developing a model to evaluate the values. (author)

  3. Eating Concerns in College Women across Sexual Orientation Identities

    Science.gov (United States)

    Maloch, Janelle K.; Bieschke, Kathleen J.; McAleavey, Andrew A.; Locke, Benjamin D.

    2013-01-01

    This study found that treatment-seeking sexual minority college women evidenced serious eating concerns. Regardless of sexual orientation and compared with those with low levels of eating concerns, women with high levels of eating concerns evidenced increased depression, increased generalized anxiety, and a greater likelihood of experiencing…

  4. Adolescents' Concerns as Reported by Adolescents, Teachers, and Parents.

    Science.gov (United States)

    Weiler, Robert M.; And Others

    1994-01-01

    To determine similarities and differences between concerns of adolescents and teachers' and parents' beliefs about adolescent concerns, data were collected from secondary students, teachers, and parents. Top 5 concerns of students were being successful, choosing a career, making good grades, what I'll be like in 10 years, and having friends. These…

  5. Inclusive Education: The Parents’ Concerns and Expectations

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2015-06-01

    Full Text Available The article revealed the opinions of the pupils’ parents about where should their children’s peers with minor mental disorders and/or physical disabilities learn and develop. Based uponthe results of studies conducted in 2002 and 2012 it becomes clear that the changes of education reality had impact also to the parents’ of pupils approach to integrated education: former vision of inclusive education became a reality. Respondents agree that their children may attend general education school together with their disabled peers. At the beginning of the year 2002 half of the respondents said that children with disabilities may learn in common classes. This is the model of natural integration. The study repeated after ten years revealed that the opinionsof the parents apparently had changed: 52 percent of respondents indicated that children with disabilities should learn in separate classes.

  6. CENDL-3 and the works concerned

    International Nuclear Information System (INIS)

    Chinese Evaluated Nuclear Data Library third version (CENDL-3.0) contains the nuclear data evaluated works, which were performed during the period of 1995-2000 at China Nuclear Data Center (CNDC) in cooperation with China Nuclear Data Coordination Network (CNDCN), including the neutron data for about 200 nuclides in ENDF/B-6 format in energy region of 10-5 eV-20 MeV. For most important nuclei the comparisons with other nuclear data libraries (ENDF, JENDL, BROND, JEF, et al.) have been performed, and the benchmark testing for the most important nuclei also have been done. CNDC and CNDCN also have got a lot of progress in the fields of nuclear data theory study, model and code developments, and nuclear database establishment etc. The status of CENDL-3 and some progress of the nuclear data evaluation studies in the past several years will be introduced in this presentation. (author)

  7. Conceptual issues concerning generalized parton distributions

    International Nuclear Information System (INIS)

    We review the interface between the current theoretical framework based on generalized parton distributions (GPDs) and experimental measurements of deeply virtual Compton scattering (DVCS) observables. We find that the present theoretical framework needs to be extended to cover the current and future DVCS experiments. The current formulation is based on the quantum chromodynamics factorization of the handbag diagrams, relying on handbag dominance. Our examination reveals that the handbag diagrams by themselves do not satisfy electromagnetic gauge invariance. Our numerical estimates of the DVCS amplitudes in a solvable model indicate that the handbag contribution is not sufficient to saturate the exact result. Assuming the extraction of GPDs is made, we analyzed the crossover point in GPDs, important for the single spin asymmetry seen in DVCS experiments. We found that the inclusion of the higher Fock states is essential to explain the available data of single spin asymmetry. (author)

  8. The experiences, needs and concerns of younger women with breast cancer: a meta-ethnography

    OpenAIRE

    Adams, Eike; McCann, Lisa; Armes, Jo; Richardson, Alison; Stark, Daniel; Watson, Eila; Hubbard, Gill

    2010-01-01

    Objective: This meta-ethnography synthesises the evidence on the experiences, needs and concerns of younger women with breast cancer. Methods: Using a method called reciprocal translation we developed a conceptual model to reflect the local and social contexts, issues, processes, needs and concerns of importance in this literature. Findings: Key findings relate to the particular point in the life-course at which young women with breast cancer stand. Issues for these women relate to ...

  9. Online consumer privacy concern and willingness to provide personal data on the internet

    OpenAIRE

    Lancelot Miltgen, Caroline

    2009-01-01

    Our research examines the manner in which Web users choose between participation in the Internet economy and protection of their personal data. We study the influence of various contextual elements (e.g. the privacy policies posted on sites) and individual characteristics (e.g. privacy concern) on willingness to communicate personal data online. An experimental study carried out on a sample of French students provides the framework for testing a conceptual model. The impact of privacy concern...

  10. Some open questions concerning biological growth

    Directory of Open Access Journals (Sweden)

    Escudero, Carlos

    2010-12-01

    Full Text Available We briefly review the properties of radially growing interfaces and their connection to biological growth. We focus on simplified models which result from the abstraction of only considering domain growth and not the interface curvature. Linear equations can be exactly solved and the phenomenology of growth can be inferred from the explicit solutions. Nonlinear equations pose interesting open questions that are summarized herein.

    En este trabajo revisamos brevemente las propiedades de las superficies que crecen de forma radial y su conexión con el crecimiento biológico. Nos vamos a concentrar en modelos simplificados que resultan de la abstracción de sólo considerar el crecimiento del dominio y no la curvatura de la interfaz. Las ecuaciones lineales se pueden resolver exactamente y la fenomenología del crecimiento puede ser inferida de las soluciones explítas. Las ecuaciones no lineales dan lugar a interesantes problemas abiertos que vamos a resumir aquí.

  11. Current understanding concerning intestinal stem cells

    Science.gov (United States)

    Cui, Shuang; Chang, Peng-Yu

    2016-01-01

    In mammals, the intestinal epithelium is a tissue that contains two distinct pools of stem cells: active intestinal stem cells and reserve intestinal stem cells. The former are located in the crypt basement membrane and are responsible for maintaining epithelial homeostasis under intact conditions, whereas the latter exhibit the capacity to facilitate epithelial regeneration after injury. These two pools of cells can convert into each other, maintaining their quantitative balance. In terms of the active intestinal stem cells, their development into functional epithelium is precisely controlled by the following signaling pathways: Wnt/β-catenin, Ras/Raf/Mek/Erk/MAPK, Notch and BMP/Smad. However, mutations in some of the key regulator genes associated with these signaling pathways, such as APC, Kras and Smad4, are also highly associated with gut malformations. At this point, clarifying the biological characteristics of intestinal stem cells will increase the feasibility of preventing or treating some intestinal diseases, such as colorectal cancer. Moreover, as preclinical data demonstrate the therapeutic effects of colon stem cells on murine models of experimental colitis, the prospects of stem cell-based regenerative treatments for ulcerous lesions in the gastrointestinal tract will be improved all the same. PMID:27610020

  12. PBT assessment and prioritization of contaminants of emerging concern: Pharmaceuticals.

    Science.gov (United States)

    Sangion, Alessandro; Gramatica, Paola

    2016-05-01

    The strong and widespread use of pharmaceuticals, together with incorrect disposal procedures, has recently made these products contaminants of emerging concern (CEC). Unfortunately, little is known about pharmaceuticals' environmental behaviour and ecotoxicity, so that EMEA (European Medicines Agency) released guidelines for the pharmaceuticals' environmental risk assessment. In particular, there is a severe lack of information about persistence, bioaccumulation and toxicity (PBT) of the majority of the thousands of substances on the market. Computational tools, like QSAR (Quantitative Structure Activity Relationship) models, are the only way to screen large sets of chemicals in short time, with the aim of ranking, highlighting and prioritizing the most environmentally hazardous for focusing further experimental studies. In this work we propose a screening method to assess the potential persistence, bioaccumulation and toxicity of more than 1200 pharmaceutical ingredients, based on the application of two different QSAR models. We applied the Insubria-PBT Index, a MLR (Multiple Linear Regression) QSAR model based on four simple molecular descriptors, implemented in QSARINS software, and able to synthesize the PBT potential in a unique cumulative value and the US-EPA PBT Profiler that assesses the PBT behaviour evaluating separately P, B and T. Particular attention was given to the study of Applicability Domain in order to provide reliable predictions. An agreement of 86% was found between the two models and a priority list of 35 pharmaceuticals, highlighted as potential PBTs by consensus, was proposed for further experimental validation. Moreover, the results of this computational screening are in agreement with preliminary experimental data in the literature. This study shows how in silico models can be applied in the hazard assessment to perform preliminary screening and prioritization of chemicals, and how the identification of the structural features, mainly

  13. Binding mechanisms in chromite briquettes at low and high temperatures

    International Nuclear Information System (INIS)

    A high percentage of South African chromium ore occurs as fines. One way in which these fines can be utilized in an arc furnace, which is currently the most widely used type of furnace for the reduction of chromium ore, is as briquettes. The briquettes should have reasonable green strength to facilitate handling and, after being cured, they should be strong enough to be fed to the furnace. Cohesion should also be maintained up to high temperatures, preferably close to the sintering temperature of chromite under reducing conditions, i.e. 1200 to 1300 degrees Celsius for South African chromite. With this in mind, a series of briquettes made with different binding media were subjected to mineralogical examination such as x-ray diffraction, infrared spectroscopy, differential thermal analysis and energy-dispersive spectroscopy with a scanning electron microscope, so that the reactions that take place in the binding media and the temperatures at which they take place could be established. In this report, the results are discussed and correlated with the strength of the briquettes in each case. The assumptions on which the calculations for the binding materials were based are detailed in an appendix

  14. Romanian concern for advanced fuels development

    International Nuclear Information System (INIS)

    The Institute for Nuclear Research (ICN), a subsidiary of Romanian Authority for Nuclear Activities, at Pitesti - Romania, has developed a preliminary design of a fuel bundle with 43 elements named SEU 43 for high burnup in CANDU Reactor. A very high experience in nuclear fuels manufacturing and control has also been accumulated. Additionally, on the nuclear site Pitesti there is the Nuclear Fuel Plant (NFP) qualified to manufacturing CANDU 6 type fuel, the main fuel supplier for NPP Cernavoda. A very good collaboration of ICN with NFP can lead to a low cost upgrading the facilities which ensure at present the CANDU standard fuel fabrication to be able of manufacturing also SEU 43 fuel for extended burnup. The financial founds are allocated by Romanian Authority for Nuclear Activities of the Ministry of Industry and Resources to sustain the departmental R and D program 'Nuclear Fuel'. This Program has the main objective to establish a technology for manufacturing a new CANDU fuel type destined for extended burnup. It is studied the possibility to use the Recovered Uranium (RU) resulted from LWR spent fuel reprocessing facility existing in stockpiles. The International Agency for Atomic Energy (IAEA) sustains also this program. By ROM/4/025/ Model Project, IAEA helps ICN to solve the problems regarding materials (RU, Zircaloy 4 tubes) purchasing, devices' upgrading and personnel training. The paper presents the main actions needing to be create the technical base for SEU 43 fuel bundle manufacturing. First step, the technological experiments and experimental fuel element manufacturing, will be accomplished in ICN installations. Second step, the industrial scale, need thorough studies for each installation from NFP to determine tools and technology modification imposed by the new CANDU fuel bundle manufacturing. All modifications must be done such as to the NFP, standard CANDU and SEU fuel bundles to be manufactured alternatively. (author)

  15. Symmetry Concerns as a Symptom of Body Dysmorphic Disorder.

    Science.gov (United States)

    Hart, Ashley S; Phillips, Katharine A

    2013-07-01

    Symmetry obsessions are a common symptom of obsessive-compulsive disorder (OCD) and have several demographic and clinical correlates. Appearance-related symmetry concerns appear common in body dysmorphic disorder (BDD); however, no published studies have examined this topic. This study examined the clinical features, prevalence, and correlates of symmetry concerns involving physical appearance in two BDD samples (N=160 and N=115). More than 25% of participants in each sample reported symmetry concerns for a body part with which they were preoccupied (total of 18 body parts in sample 1 and 18 in sample 2). In sample 1, BDD participants with appearance-related symmetry concerns were older than those without appearance-related symmetry concerns. In sample 2, those with appearance-related symmetry concerns reported poorer mental health-related quality of life, were more likely to have experienced lifetime suicidal ideation, had better BDD-related insight, and were less likely to have a lifetime eating disorder. In both samples, participants with appearance-related symmetry concerns were more likely to have lifetime OCD but not OCD-related symmetry obsessions. Thus, symmetry is a common appearance concern in BDD that is associated with comorbid OCD but not with OCD symmetry concerns specifically, suggesting that symmetry concerns may have a different mechanism/pathophysiology in BDD versus OCD. PMID:24058899

  16. SOCIA: Linked Open Data of Context behind Local Concerns for Supporting Public Participation

    Directory of Open Access Journals (Sweden)

    Shun Shiramatsu

    2015-02-01

    Full Text Available To address public concerns that threat the sustain-ability of local societies, supporting public participation by shar-ing the background context behind these concerns is essentially important. We designed a SOCIA ontology, which was a linked data model, for sharing context behind local concerns with two approaches: (1 structuring Web news articles and microblogs about local concerns on the basis of geographical regions and events that were referred to by content, and (2 structuring public issues and their solutions as public goals. We moreover built a SOCIA dataset, which was a linked open dataset, on the basis of the SOCIA ontology. Web news articles and microblogs related to local concerns were semi-automatically gathered and structured. Public issues and goals were manually extracted from Web content related to revitalization from the Great East Japan Earthquake. Towards more accurate extraction of public concerns, we investigated feature expressions for extracting public concerns from microblogs written in Japanese. To address a technical issue about sample selection bias in our microblog corpus, we formulated a metric in mining feature expressions, i.e., bias-penalized information gain (BPIG. Furthermore, we developed a prototype of a public debate support system that utilized the SOCIA dataset and formulated the similarity between public goals for a goal matching service to facilitate collaboration.

  17. How does market concern derived from the Internet affect oil prices?

    International Nuclear Information System (INIS)

    Highlights: • The impact of market concern derived from the Web on oil volatility is analysed. • It has an equilibrium relationship between oil prices and long-run market concern. • The short-run market concerns have an asymmetric influence on oil price volatility. • The Internet can exaggerate the impact of information shocks on oil price. - Abstract: With the acceleration of oil marketisation and the rapid development of electronic information carriers, external information shocks can be easily and quickly transmitted to the oil market through the Internet. This paper analyses the impact of short- and long-run market concerns, derived from search query volumes in Google for different domains around the oil market on oil volatility using co-integration and the modified EGARCH model. Empirical results suggest there is a long-term equilibrium relationship between oil prices and long-run market concern for oil prices and oil demand. The short-run market concerns for the 2008 financial crisis and the Libyan war convulsion have a significant and asymmetric influence on oil price volatility. This indicates that market concern transmitted through the Internet can strengthen the linkage between oil price changes and external events by influencing the expectation of market traders, and to some extent it can exaggerate the impact of nonfundamental information shocks

  18. Inflow shortages in deregulated power markets - Reasons for concern?

    International Nuclear Information System (INIS)

    In many countries hydropower constitutes a large share of the electricity producing capacity. In the earlier regulated electricity markets, production capacities exceeded demand due to security of supply concerns. The present deregulated markets base investments upon profitability alone, and security of supply issues are claimed to be less important. Market operators trust the pricing mechanism in competitive markets to clear. Then low inflow constitutes a less problem. Several markets, both under regulated and deregulated regimes, have faced serious droughts. Some of them have experienced problems with market clearance (Chile, Brazil, California) while other markets functioned well (The Nordic market). Important features to the market response are the flexibility of demand, the pattern of inflow shortage, the storage capacities, the possibility of trade between regions with different production technologies, and the market design and concentration. We apply an empirical based market model to simulate the effects under two inflow shortage scenarios in an international market with combined hydro and thermal capacities and restricted transmission capacities. We compare the scenarios with actual events and show that the model and the real market outcome are comparable. The simulations do not reveal any problems with the functioning of the market, which should calm down the anxiousness about security of supply in deregulated markets with stochastic energy supply

  19. Inflow shortages in deregulated power markets - Reasons for concern?

    International Nuclear Information System (INIS)

    In many countries hydropower constitutes a large share of the electricity producing capacity. In the earlier regulated electricity markets, production capacities exceeded demand due to security of supply concerns. The present deregulated markets base investments upon profitability alone, and security of supply issues are claimed to be less important. Market operators trust the pricing mechanism in competitive markets to clear. Then low inflow constitutes a less problem. Several markets, both under regulated and deregulated regimes, have faced serious droughts. Some of them have experienced problems with market clearance (Chile, Brazil, California) while other markets functioned well (The Nordic market). Important features to the market response are the flexibility of demand, the pattern of inflow shortage, the storage capacities, the possibility of trade between regions with different production technologies, and the market design and concentration. We apply an empirical based market model to simulate the effects under two inflow shortage scenarios in an international market with combined hydro and thermal capacities and restricted transmission capacities. We compare the scenarios with actual events and show that the model and the real market outcome are comparable. The simulations do not reveal any problems with the functioning of the market, which should calm down the anxiousness about security of supply in deregulated markets with stochastic energy supply. (author)

  20. Current concerns in involuntary and voluntary autobiographical memories

    DEFF Research Database (Denmark)

    Johannessen, Kim Berg; Berntsen, Dorthe

    2010-01-01

    Involuntary autobiographical memories are conscious memories of personal events that come to mind with no preceding attempts at retrieval. It is often assumed that such memories are closely related to current concerns - i.e., uncompleted personal goals. Here we examined involuntary versus voluntary...... (deliberately retrieved) autobiographical memories in relation to earlier registered current concerns measured by the Personal Concern Inventory (PCI; Cox & Klinger, 2000). We found no differences between involuntary and voluntary memories with regard to frequency or characteristics of current concern related...... contents. However, memories related to current concerns were rated as more central to the person's identity, life story and expectations for the future than non-concern related memories, irrespective of mode of recall. Depression and PTSD symptoms correlated positively with the proportion of current...

  1. A concern-oriented approach to software architecture

    OpenAIRE

    Kandé, Mohamed Mancona; Strohmeier, Alfred

    2005-01-01

    A major cause of many complications in the field of software architectures is the lack of appropriate abstractions for separating, combining and encapsulating concerns of various kinds in architectural descriptions. Architectures of most complex software-intensive systems involve concerns that inherently crosscut the natural boundaries of the elements composing the architecture descriptions. Crosscutting concerns intersect the common modularity of systems as prescribed by their architecture d...

  2. A concern-oriented approach to software architecture

    OpenAIRE

    Kandé, Mohamed Mancona

    2003-01-01

    A major cause of many complications in the field of software architectures is the lack of appropriate abstractions for separating, combining and encapsulating concerns of various kinds in architectural descriptions. Architectures of most complex software-intensive systems involve concerns that inherently crosscut the natural boundaries of the elements composing the architecture descriptions. Crosscutting concerns intersect the common modularity of systems as prescribed by their architecture ...

  3. POLICY CONCERNS FOR ONLINE B2B EXCHANGES

    OpenAIRE

    Hooker, Neal H.; Rha, Jong-Youn; Ernst, Stanley C.; Widdows, Richard

    2002-01-01

    Policy concerns arise as e-business activities become increasingly common. This paper discusses important elements of such concerns, particularly the pro- and anti-competitive assessment of online business-to-business (B2B) exchanges. The definition of markets, the role of quality management and communication, and join purchasing implications within such environments are related to food distribution systems. Other online business-to-consumer (B2C) and consumer-to-business (C2B) policy concern...

  4. On the Determinants of Terrorism Risk Concern in Europe

    OpenAIRE

    Drakos, Konstantinos; Müller, Cathérine

    2010-01-01

    We investigate whether differences in terrorism risk are mirrored on terrorism risk concern across European countries for the period 2003-2007. We find that the average propensity for terrorism risk concern is indeed affected by actual risk levels. Furthermore, country and individual heterogeneity contribute substantially to the variation of observed risk concern. According to our findings, males, singles and individuals with white collar jobs are less likely to mention terrorism as one of th...

  5. Ethical Concern in Joseph Heller’s Catch-22

    Institute of Scientific and Technical Information of China (English)

    XIAN Yu-jing

    2015-01-01

    In Catch-22, Joseph Heller shows his ethical concern behind absurdity, which is manifested from his attitude toward individualism and utilitarianism, religious belief, sexual promiscuity, interpersonal relationship, etc.

  6. 7 CFR 54.15 - Advance information concerning service rendered.

    Science.gov (United States)

    2010-01-01

    ... concerning the determination of class, grade, other quality, or compliance of products for such applicant may... (CONTINUED) MEATS, PREPARED MEATS, AND MEAT PRODUCTS (GRADING, CERTIFICATION, AND STANDARDS)...

  7. Concerns of stem cell transplant patients during routine ambulatory assessment

    Directory of Open Access Journals (Sweden)

    Klein C

    2013-01-01

    Full Text Available Lisa Kennedy Sheldon,1 Maryum Kazmi,1 Cynthia Klein,2 Donna L Berry31University of Massachusetts Boston, Boston, MA, 2Seattle Cancer Care Alliance, Seattle, WA, 3Phyllis Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, Boston, MA, USABackground: Stem cell transplant (SCT is a treatment choice for many hematological malignancies. There is currently a lack of evidence regarding the self-reported concerns of SCT patients before and after SCT.Aim and design: This exploratory study performed a secondary analysis of self-reported, written concerns of SCT patients before and after transplant to determine patients' concerns.Methods: Content analysis of text box entries of SCT patients collected between 2005 and 2007 at the Seattle Cancer Care Alliance. Text box entries were collected as part of symptom assessment using the Electronic Self-Report Assessment – Cancer instrument. The assessment was presented to 137 patients undergoing SCT at two time points: prior to ambulatory visits before any therapy had begun (T1 and at the first visit after hospital discharge following SCT (T2.Results: Text box entries were made before (n = 52 and after (n = 87 the transplant, resulting in 139 text box entries made by 137 patients representing 133 concerns. Using content analysis, the entries were categorized and ranked according to frequency. After symptom concerns, patients ranked work and financial issues the most frequent concerns prior to SCT. After SCT, symptoms remained the most frequently entered area of concern, followed by survival.Conclusion: Oncology providers need to assess SCT patients for work and financial concerns before and after transplant. Appropriate and timely referrals may ease the burden of these concerns for patients. Thus, assessment of financial and work concerns by the oncology team should be an integral part of quality health care for patients undergoing SCT.Keywords: self-report, electronic

  8. Environmental Concern and Involvement of Individuals in Selected Voluntary Associations

    Science.gov (United States)

    Schuett, Michael A.; Ostergren, David.

    2003-01-01

    The authors examined environmental concern and involvement of individuals in two voluntary associations, the International Mountain Bicycling Association (IMBA) and National Off-Highway Vehicle Conservation Council, Inc. (NOHVCC). Environmental concerns were assessed using the New Environmental Paradigm (NEP). When compared, results from 10 of 12…

  9. Environmental Concerns and the New Environmental Paradigm in Bulgaria

    Science.gov (United States)

    Bostrom, Ann; Barke, Richard; Turaga, Rama Mohana R.; O'Connor, Robert E.

    2006-01-01

    Little is known about environmental concerns and attitudes among people in former Soviet bloc countries in Eastern Europe despite widespread perceptions of severe environmental problems. The authors addressed this gap by examining Bulgarians' environmental concerns with a focus on whether the new environmental paradigm (NEP) scale can reliably…

  10. 32 CFR 643.51 - Additional items concerning leasing.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Additional items concerning leasing. 643.51... PROPERTY REAL ESTATE Leases § 643.51 Additional items concerning leasing. In addition to the general and... leasing of Army real estate....

  11. Managing nuclear knowledge: a SCK-CEN concern

    International Nuclear Information System (INIS)

    The abstracts describes the activities at SCK-CEN concerning knowledge management. Preserving and enhancing SCK-CEN's institutional memory is becoming vital. Accordingly, specific initiatives have been taken concerning sustaining nuclear education and training and stimulating the preservation and the sharing of nuclear knowledge. The status in these areas in 2003 is summarised

  12. 30 CFR 250.302 - Definitions concerning air quality.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions concerning air quality. 250.302... Definitions concerning air quality. For purposes of §§ 250.303 and 250.304 of this part: Air pollutant means..., pursuant to section 109 of the Clean Air Act, national primary or secondary ambient air quality...

  13. The Anticipation of Single Parenthood: A Profile of Men's Concerns.

    Science.gov (United States)

    Fox, Greer Litton; Bruce, Carol

    1999-01-01

    Explores whether fathers living apart from their children have concerns about possible disruptions in their relationships with their children. Results show: quality of the marital or partner relationship predicts fathers' concerns; fathers with a history of living apart from their child and maintaining high levels of involvement express the least…

  14. 9 CFR 11.2 - Prohibitions concerning exhibitors.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Prohibitions concerning exhibitors. 11.2 Section 11.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.2 Prohibitions concerning exhibitors. (a)...

  15. Chinese consumers concerns about food safety: Case of Tianjin

    NARCIS (Netherlands)

    Zhang XiaoYong, Xiaoyong

    2005-01-01

    The objective of this study is to gain an insight to Chinese consumers' knowledge and concerns over food safety from a case study in Tianjin city. The results indicate that Chinese consumers are very much concerned about food safety, particularly with regard to vegetables and dairy products. Chinese

  16. The Development of Human Resources: An International Concern.

    Science.gov (United States)

    Orfila, H. E. Alejandro; And Others

    1981-01-01

    This series of articles summarizes discussions from the Second World Conference on Cooperative Education. Topics include "Cooperative Education: A Powerful Instrument for Development and Peace;""Human Resources: An International Concern for Developing Countries;""Human Resources: A Continuing International Concern for Developed Countries;" and…

  17. The Impact of Adolescent Concerns on Their Academic Stress

    Science.gov (United States)

    Huan, Vivien S.; See, Yeo Lay; Ang, Rebecca P.; Har, Chong Wan

    2008-01-01

    The objective of this study was to examine the contributing role of the different aspects of adolescent concerns on the academic stress of youths in Singapore. Data was obtained using two self-report measures: the Adolescent Concerns Measure and the Academic Expectations Stress Inventory. The study examined four different aspects of adolescent…

  18. 12 CFR 202.7 - Rules concerning extensions of credit.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Rules concerning extensions of credit. 202.7... EQUAL CREDIT OPPORTUNITY ACT (REGULATION B) § 202.7 Rules concerning extensions of credit. (a) Individual accounts. A creditor shall not refuse to grant an individual account to a creditworthy...

  19. International antiterrorist conventions concerning the safety of air transport

    OpenAIRE

    Jacek BARCIK; Piotr CZECH

    2008-01-01

    In this article the international law regulations are presented concerning the civilian safety of the air transport. The history concerning air terrorism and international antiterrorist conventions was described in detail, involving The Chicago Convention, The Tokyo Convention, The Hague Convention and Montreal Convention.

  20. Occupational hazards concerning the dental surgeon: identification, prevention and legislation

    International Nuclear Information System (INIS)

    This thesis concerns the legislation about the work of dentistry and the different obligations relative to this work, patient protection and dental surgeon protection are concerned as well. A special point is developed relative to the radiation protection and the training necessary to control it and apply it

  1. An Overview Of The Security Concerns In Enterprise Cloud Computing

    OpenAIRE

    Anthony Bisong; Rahman, Syed M.

    2011-01-01

    Deploying cloud computing in an enterprise infrastructure bring significant security concerns.Successful implementation of cloud computing in an enterprise requires proper planning andunderstanding of emerging risks, threats, vulnerabilities, and possible countermeasures. We believe enterprise should analyze the company/organization security risks, threats, and available countermeasures before adopting this technology. In this paper, we have discussed security risks and concerns in cloud comp...

  2. An Overview of the Security Concerns in Enterprise Cloud Computing

    OpenAIRE

    Bisong, Anthony; Syed; Rahman, M.

    2011-01-01

    Deploying cloud computing in an enterprise infrastructure bring significant security concerns. Successful implementation of cloud computing in an enterprise requires proper planning and understanding of emerging risks, threats, vulnerabilities, and possible countermeasures. We believe enterprise should analyze the company/organization security risks, threats, and available countermeasures before adopting this technology. In this paper, we have discussed security risks and concerns in cloud co...

  3. 40 CFR 60.4114 - Objections concerning Hg designated representative.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Objections concerning Hg designated... Times for Coal-Fired Electric Steam Generating Units Hg Designated Representative for Hg Budget Sources § 60.4114 Objections concerning Hg designated representative. (a) Once a complete certificate...

  4. 48 CFR 871.211 - Information concerning correspondence courses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Information concerning... PROGRAMS Vocational Rehabilitation and Employment Service 871.211 Information concerning correspondence courses. Specific questions on correspondence courses as to the content of courses, academic credit,...

  5. Area of Concern: A new paradigm in life cycle assessment for the development of footprint metrics

    DEFF Research Database (Denmark)

    Ridoutt, Bradley G.; Pfister, Stephan; Manzardo, Alessandro;

    2016-01-01

    operating under the auspices of the UNEP/SETAC Life Cycle Initiative project on environmental life cycle impact assessment (LCIA) has been working to develop generic guidance for developers of footprint metrics. The purpose of this paper is to introduce a universal footprint definition and related...... terminology as well as to discuss modelling implications. The task force has worked from the perspective that footprints should be based on LCA methodology, underpinned by the same data systems and models as used in LCA. However, there are important differences in purpose and orientation relative to LCA...... area of concern as the basis for a universal footprint definition. In the same way that LCA uses impact category indicators to assess impacts that follow a common causeeffect pathway toward areas of protection, footprint metrics address areas of concern. The critical difference is that areas of concern...

  6. Adolescent Boys and Body Image: Weight and Muscularity Concerns as Dual Pathways to Body Dissatisfaction

    Science.gov (United States)

    Jones, Diane Carlson; Crawford, Joy K.

    2005-01-01

    This research evaluated a dual pathway model for body dissatisfaction among adolescent boys. The study provides empirical support for the importance of distinguishing between weight and muscularity concerns in understanding male body image. A total of 128 boys from grades 8 and 11 completed a self-report questionnaire. Results indicated that…

  7. Acquiring Consumer Trust: Minimizing the GAP Between Environmental Concern and Environmental Consumption

    Directory of Open Access Journals (Sweden)

    Elias Frederico

    2013-12-01

    Full Text Available Environmental management has become an important managerial tool for creating conditions for greater competitiveness of organizations. A significant portion of the population considers environmental issues while consuming. However, despite the proposed relationship between environmental concern and consumption, some studies have identified a gap between declared environmental concern and consumer behavior. One possible explanation for this gap is the lack of trust in the ethics of retailers and the perception that environmental appealing offers would be only artifices of marketing. Thus, this paper aims to analyze the moderating effect of trust in the relationship between Environmental concern and environmental purchase intention. To operationalize the study, an online survey was conducted among 696 Brazilian consumers. The sample was characterized as non-probabilistic. Validated scales were used to measure the variables and data were analyzed using structural equation modeling. The results show that there is a significant relationship between environmental concern and environmental purchase intention, however, the low explanatory power of the model points to the gap between discourse and practice. By analyzing the trust of consumers as moderating variable, it is clear that, by increasing consumers’ trust, the gap between environmental concern and consumption is diminished.

  8. Bulimic symptomatology: the role of adaptive perfectionism, shape and weight concern, and self-esteem.

    Science.gov (United States)

    Watson, Hunna J; Steele, Anna L; Bergin, Jacqueline L; Fursland, Anthea; Wade, Tracey D

    2011-09-01

    An interactive model implicating high perfectionism, high weight and shape concern, and low self-esteem in the onset and maintenance of bulimic symptoms (Bardone, Vohs, Abramson, Heatherton, & Joiner, 2000; Vohs, Bardone, Joiner, Abramson, & Heatherton, 1999) has received mixed support. This study aimed to replicate the cross-sectional model in a clinical sample of women with eating disorders, and to investigate whether the model could predict changes in binge eating and purging at the end of treatment. Eating disorder outpatients (n=353) completed measures of perfectionism, weight/shape concern, self-esteem, and bulimic symptoms at pre-treatment and discharge. Contrary to the hypotheses, the three-way interaction did not predict binge eating or purging cross-sectionally or prospectively as a moderator of psychotherapy outcome. It was concluded that the robustness of the interactive model seems questionable and may be impacted by an inadequate conceptualization of the perfectionism construct. PMID:21704980

  9. Will public environmental concern lead to action on global warming?

    International Nuclear Information System (INIS)

    This article demonstrates that public environmental concern has increased dramatically in recent years, and asks whether that increased concern will, or could be directed to, advance policies on global climate change. For comparison, public responses to several other environmental problems are reviewed, in an attempt to explain why public concerns have no effect in some cases and quite dramatic effects in others. Most of the article covers environmental issues in the US, where the greatest amount of data are available. A concluding section evaluates the extent to which the conclusions can be extended to other countries. 111 refs

  10. Ancient Maya documents concerning the movements of Mars

    OpenAIRE

    Bricker, Harvey M.; Aveni, Anthony F.; Bricker, Victoria R.

    2001-01-01

    A large part of the pre-Columbian Maya book known as the Dresden Codex is concerned with an exploration of commensurate relationships among celestial cycles and their relationship to other, nonastronomical cycles of cultural interest. As has long been known, pages 43b–45b of the Codex are concerned with the synodic cycle of Mars. New work reported here with another part of the Codex, a complex table on pages 69–74, reveals a concern on the part of the ancient Maya astr...

  11. Separating variability concerns in a product line re-engineering project

    DEFF Research Database (Denmark)

    Hubaux, Arnaud; Heymans, Patrick; Unphon, Hataichanok

    2008-01-01

    Feature diagrams have now become common variability models in software product lines engineering literature. Whereas ongoing research keeps improving their expressiveness, formalisation, and automation, open studies of their usage in real projects are still missing. This paper intends to (1......) present the process we followed to elicit the variability of PloneMeeting, an Open Source project, and (2) report on the initial results obtained when applying variability modelling techniques promoting separation of concerns between software variability and product line variability....

  12. On an Inequality Concerning the Polar Derivative of a Polynomial

    Indian Academy of Sciences (India)

    A Aziz; N A Rather

    2007-08-01

    In this paper, we present a correct proof of an -inequality concerning the polar derivative of a polynomial with restricted zeros. We also extend Zygmund’s inequality to the polar derivative of a polynomial.

  13. Serious Concerns Over Alcoholic Beverages with Added Caffeine

    Science.gov (United States)

    ... Espanol Serious Concerns Over Alcoholic Beverages with Added Caffeine Please share copies of this printer-friendly PDF ( ... beverages, or CABs, are alcoholic beverages that contain caffeine as an additive and are packaged in combined ...

  14. Identifying refuge resources of concern and management priorities : A handbook

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This handbook provides a strategy for anyone who must identify priorities (refuge resources of concern) that will guide future refuge wildlife and habitat...

  15. Concerns and coping styles in adolescents from Lima

    Directory of Open Access Journals (Sweden)

    Patricia Martínez Uribe

    2001-12-01

    Full Text Available Combining qualitative and quantitative methodology, the study describes the main concerns of a group of adolescents and the strategies they use to cope with such concerns according to socio-demographic variables (age, sex and type of school. It is a descriptive study, with a transsectional design, of 413 adolescents from 13 to 18 years. The used instrument was the specific form of the Adolescent Coping Scale (ACS (Frydenberg & Lewis, 1997 that included oneopen question regarding their main concern. It was found that their major concerns are centeredin their future and school performance and that the most used coping strategies were Concernand Work Hard. It was found that socio-demographic variables make important differences among the different groups.

  16. Safe Integration of Concerns in a Software Architecture

    DEFF Research Database (Denmark)

    Barais, Olivier; Lawall, Julia Laetitia; Le Meur, Anne-Francoise;

    2006-01-01

    Software architectures must frequently evolve to cope with changing requirements, and this evolution often implies integrating new concerns. Unfortunately, existing architecture description languages provide little or no support for this kind of evolution. The software architect must modify the...... architecture manually, which risks introducing inconsistencies. In previous work, we have proposed the TranSAT framework, which provides a pattern construct for describing new concerns and their integration into an existing architecture. As the interaction between the new concern and the existing architecture...... may be complex, it is essential that the framework ensure the coherence of the resulting architecture. In this paper, we introduce a language for specifying patterns and verifications that ensure that the concern represented by a pattern can be safely integrated into an existing architecture. The...

  17. Dynamics of the public concern and risk communication program implementation.

    Science.gov (United States)

    Zaryabova, Victoria; Israel, Michel

    2015-09-01

    The public concern about electromagnetic field (EMF) exposure varies due to different reasons. A part of them are connected with the better and higher quality of information that people receive from science, media, Internet, social networks, industry, but others are based on good communication programs performed by the responsible institutions, administration and persons. Especially, in Bulgaria, public concern follows interesting changes, some of them in correlation with the European processes of concern, but others following the economic and political processes in the country. Here, we analyze the dynamics of the public concern over the last 10 years. Our explanation of the decrease of the people's complaints against EMF exposure from base stations for mobile communication is as a result of our risk communication program that is in implementation for >10 years. PMID:26444205

  18. Moral concerns on tradable pollution permits in international environmental agreements

    Energy Technology Data Exchange (ETDEWEB)

    Eyckmans, Johan [Hogeschool-Universiteit Brussel - HUB, Stormstraat 2, B-1000 Brussels (Belgium); Katholieke Universiteit Leuven, Centrum voor Economische Studien Naamsestraat 69, 3000 Leuven (Belgium); Kverndokk, Snorre [Ragnar Frisch Centre for Economic Research, Gaustadalleen 21, 0349 Oslo (Norway)

    2010-07-15

    We investigate how moral concerns about permit trading affect an endogenous pollution permit trading equilibrium, where governments choose non-cooperatively the amount of permits they allocate to domestic industries. Politicians may feel reluctant to allow permit trading and/or may prefer that abatement is undertaken domestically because of moral concerns. This will have an effect on the initial permit allocations, and, therefore, on global emissions. The impact on global emissions depends on the precise formulation of the moral concerns, but under reasonable assumptions, we show that global emissions may increase. Thus, doing what is perceived as good does not always yield the desired outcome. However, this can be offset by restrictions on permit trading when governments have moral concerns about this trade. (author)

  19. Moral concerns on tradable pollution permits in international environmental agreements

    International Nuclear Information System (INIS)

    We investigate how moral concerns about permit trading affect an endogenous pollution permit trading equilibrium, where governments choose non-cooperatively the amount of permits they allocate to domestic industries. Politicians may feel reluctant to allow permit trading and/or may prefer that abatement is undertaken domestically because of moral concerns. This will have an effect on the initial permit allocations, and, therefore, on global emissions. The impact on global emissions depends on the precise formulation of the moral concerns, but under reasonable assumptions, we show that global emissions may increase. Thus, doing what is perceived as good does not always yield the desired outcome. However, this can be offset by restrictions on permit trading when governments have moral concerns about this trade. (author)

  20. Montana National Wildlife Refuges: Contaminant issues of concern

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to: (1) identify specific contaminant issues of concern for each Montana refuge and wetland management district; (2) summarize the...

  1. Public concerns of nuclear waste issues in Taiwan

    International Nuclear Information System (INIS)

    This paper discusses opinions and comments from randomly selected 1837 general public and 454 professionals compiled and analyzed to obtain their concerns on nuclear waste issues in Taiwan. Results are presented. A public education and promotion program is suggested

  2. Fears and concerns of Iranian diabetic women: A phenomenological study.

    Science.gov (United States)

    Aghamohammadi-Kalkhoran, Masoumeh; Valizadeh, Sousan

    2016-07-01

    This study explored the fears and concerns of 19 Iranian diabetic women using a phenomenological approach. Semistructured individual interviews were conducted; each interview was transcribed verbatim and analyzed simultaneously using Van Manen's method. Data analysis resulted in the emergence of two main themes: (1) "a vague and uncertain future" with sub-themes of "fears of dependency," "loneliness," "disease complications," and "children's future"; and (2) "changing lifestyles" with sub-themes of "dietary restrictions" and "insulin injection." Psychological concerns are common in Iranian diabetic women. These concerns can contribute to poor disease self-management. Thus, it is hoped that identifying these concerns can lead to better management of these issues and a better outcome in diabetic patients. PMID:25305192

  3. International regulations concerning radiosterilization; Aktualne przepisy miedzynarodowe dotyczace sterylizacji radiacyjnej

    Energy Technology Data Exchange (ETDEWEB)

    Kaluska, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1997-10-01

    European norms (EN 552) and international regulations (ISO 11137) concerning commercial radiosterilization have been described. Licensing of irradiation installation as well as sterilization procedure requirements, and routine control have been discussed in detail. 3 refs.

  4. Some practical issues concerning International Arbitration in Japan

    OpenAIRE

    Nagata, Mari

    2013-01-01

    This article deals with the current problems concerning international arbitration in Japan. This article overviews some of the cases since Japan's Arbitration Act came into force about a decade ago and reveals practical problems in its application.

  5. Highlighting Hospital and Patient Concerns this Election Year.

    Science.gov (United States)

    Nickels, Tom

    2016-03-01

    Campaign 2016 is in full swing, and the American Hospital Association is seizing the opportunity to make sure the concerns of patients and hospitals are heard. On the front burner: escalating drug prices. PMID:27180391

  6. ENVIRONMENTAL EDUCATION AND BIODIVERSITY CONCERN: BEYOND THE ECOLOGICAL LITERACY

    OpenAIRE

    Carlos Hiroo Saito

    2013-01-01

    This is a review article on environmental education. The focus of the discussion is the relationship between environmental education and Biodiversity concern and the emergence of the concept of Biodiversity education. The position described here configures as a disagreement of the insertion of these innovative terminology, defending the maintenance of the term environmental education and its general framework, reserving to Biodiversity concern a position of one issue to be coped by environmen...

  7. Concerns and confidence of general practitioners in providing telephone consultations.

    OpenAIRE

    Foster, J.; Jessopp, L; Dale, J

    1999-01-01

    BACKGROUND: In recent years the number of telephone consultations provided out of hours has increased. However, most general practitioners (GPs) have received little training in this area despite the specific skills needed to compensate for lack of visual information. Moreover, there has been no research exploring GPs' concerns and training needs in telephone consulting. AIM: To assess GPs' concerns and levels of confidence in providing telephone consultations in order to inform the developme...

  8. Predictors of parental perceptions and concerns about child weight

    OpenAIRE

    Keller, Kathleen L.; Olsen, Annemarie; Kuilema, Laura; Meyermann, Karol; van Belle, Christopher

    2012-01-01

    Appropriate levels of parental perception and concern about child weight are important components of successful obesity treatment, but the factors that contribute to these attitudes need clarification. The aim of this study was to identify child and parent characteristics that best predict parental perceptions and concerns about child weight. A cross-sectional design was used to assess characteristics of parents (e.g. age, income, and feeding attitudes) and children (e.g. body composition, ad...

  9. Investigation concerning geologic storage of radioactive waste in the Netherlands

    International Nuclear Information System (INIS)

    The first stage of the research program concerning geological storage of radioactive waste in the Netherlands encloses desk studies for the preparation of a selection out of a number of locations for closer field examination, and of a choice of the most proper storage technique (mines, deep boreholes, caverns). This report is the first of two intermediate reports concerning the state of affairs of this first stage. 10 refs.; 6 figs

  10. Addressing community concerns about asthma and air toxics.

    OpenAIRE

    White, Mary C.; Berger-Frank, Sherri A; Middleton, Dannie C.; Falk, Henry

    2002-01-01

    People with asthma who live near or downwind from a source of toxic emissions commonly express concerns about the possible impact of hazardous air pollution on their health, especially when these emissions are visible or odorous. Citizens frequently turn to their local and state health departments for answers, but health departments face many challenges in addressing these concerns. These challenges include a lack of asthma statistics at the local level, limited exposure information, and a pa...

  11. Gender differences in anxiety and concerns about the cardioverter defibrillator

    DEFF Research Database (Denmark)

    Spindler, Helle; Johansen, Jens B; Andersen, Kirsten Krogh;

    2009-01-01

    Little is known about gender differences in the response to implantable cardioverter defibrillator (ICD) therapy. We compared female and male ICD patients on anxiety, depression, health-related quality of life (HRQL), ICD concerns, and ICD acceptance.......Little is known about gender differences in the response to implantable cardioverter defibrillator (ICD) therapy. We compared female and male ICD patients on anxiety, depression, health-related quality of life (HRQL), ICD concerns, and ICD acceptance....

  12. Addressing Parental Vaccine Concerns: Engagement, Balance, and Timing

    OpenAIRE

    Glanz, Jason M.; Kraus, Courtney R.; Daley, Matthew F.

    2015-01-01

    The recent United States measles epidemic has sparked another contentious national discussion about childhood vaccination. A growing number of parents are expressing concerns about the safety of vaccines, often fueled by misinformation from the internet, books, and other nonmedical sources. Many of these concerned parents are choosing to refuse or delay childhood vaccines, placing their children and surrounding communities at risk for serious diseases that are nearly 100% preventable with vac...

  13. Symmetry Concerns as a Symptom of Body Dysmorphic Disorder

    OpenAIRE

    Hart, Ashley S.; Phillips, Katharine A.

    2013-01-01

    Symmetry obsessions are a common symptom of obsessive-compulsive disorder (OCD) and have several demographic and clinical correlates. Appearance-related symmetry concerns appear common in body dysmorphic disorder (BDD); however, no published studies have examined this topic. This study examined the clinical features, prevalence, and correlates of symmetry concerns involving physical appearance in two BDD samples (N=160 and N=115). More than 25% of participants in each sample reported symmetry...

  14. Drawing the boundaries of nanoscience--rationalizing the concerns?

    Science.gov (United States)

    Kaiser, Mario

    2006-01-01

    Nanotechnology as an emerging field is strongly related to visionary prospects which are disposed to reappear as dystopian concerns. As long as nanotechnology does not provide reliable criteria for assessing these worries as rational or as irrational they remain a challenge for ethical reflection. Given this underdetermination, many nanovisions and their corresponding concerns should therefore be considered as "arational." For that reason, a "constructivist" stance is endorsed which does not seek to take part in discussions as to how ethicists should cope with controversial worries, but tries to observe how concerns are managed by different social actors. This perspective allows us to remodel some concerns such as "grey goo" not solely as a societal reaction, but also as challenging and irritating factors. As such they potentially initiate two different processes simultaneously: a differentiation in terms of demarcating science from non-science on the one hand, and a rationalization of concerns on the other. Analyzing these processes empirically allows to reconstruct how "arational" concerns are socially made rational or, on the contrary, irrational. PMID:17199807

  15. Resident's concerns and attitudes towards Solid Waste Management facilities

    International Nuclear Information System (INIS)

    Because of limited space, the siting and construction of a new SWM facility is a big challenge in Japan. An SWM facility should be socially accepted as well as environmentally and economically sound. This study aimed to investigate people's concerns about SWM facilities and their attitudes towards such facilities. A questionnaire was designed based on literature reviews and was sent to residents in three municipalities with different backgrounds. The questions covered concerns on the impact of an SWM facility, management aspects, unfairness of facility siting, and attitudes to facility construction. Of the many concerns, 'pollution and health effect' had the highest rating, followed by 'reliability', 'damage to nature' and 'cost'. The rating was different between municipalities, reflecting their geographic and social backgrounds. Using factor analysis, correlations among concerns were analyzed, and five principal components were extracted, namely 'pollution', 'nuisance', 'facility management', 'planning of facility', and 'merit/demerit'. Although obvious correlations were not found between individual items of concern and attitudes to construction of a facility, the discriminant analysis indicated dominant concerns of attitudes, but the disagreement between actual impact and citizens were found. As for attributes, the 'opposed' attitude decreased for residents who had visited an SWM facility, even if they had only seen it from outside

  16. General Practitioners’ Knowledge and Concern about Electromagnetic Fields

    Directory of Open Access Journals (Sweden)

    Gabriele Berg-Beckhoff

    2014-12-01

    Full Text Available Our aim is to explore general practitioners’ (GPs’ knowledge about EMF, and to assess whether different knowledge structures are related to the GPs’ concern about EMF. Random samples were drawn from lists of GPs in Germany in 2008. Knowledge about EMF was assessed by seven items. A latent class analysis was conducted to identify latent structures in GPs’ knowledge. Further, the GPs’ concern about EMF health risk was measured using a score comprising six items. The association between GPs’ concern about EMF and their knowledge was analysed using multiple linear regression. In total 435 (response rate 23.3% GPs participated in the study. Four groups were identified by the latent class analysis: 43.1% of the GPs gave mainly correct answers; 23.7% of the GPs answered low frequency EMF questions correctly; 19.2% answered only the questions relating EMF with health risks, and 14.0% answered mostly “don’t know”. There was no association between GPs’ latent knowledge classes or between the number of correct answers given by the GPs and their EMF concern, whereas the number of incorrect answers was associated with EMF concern. Greater EMF concern in subjects with more incorrect answers suggests paying particular attention to misconceptions regarding EMF in risk communication.

  17. Studies on the tumor cells binding mechanism of the long-circulating liposomes loading docetaxel mediated by folic acid receptor%叶酸受体介导多西他赛长循环脂质体与肿瘤细胞结合机理的研究

    Institute of Scientific and Technical Information of China (English)

    苑振贵; 陈大为; 张守堂; 苏书华

    2011-01-01

    目的 研究叶酸受体介导多西他赛长循环脂质体与肿瘤细胞的结合机理.方法 采用薄膜分散法制备脂质体,采用荧光法、流式细胞仪和荧光显微镜检测脂质体与 MCF-7 细胞、Hela 细胞的结合.结果 叶酸受体介导多西他赛长循环脂质体与 MCF-7 细胞的结合量大于 Hela 细胞;游离叶酸可竞争抑制叶酸受体介导多西他赛长循环脂质体与 MCF-7 细胞的结合;荧光显微镜下,MCF-7细胞可见明亮绿色荧光,而 Hela 细胞中只有微弱绿色荧光.结论 叶酸受体介导多西他赛长循环脂质体是通过叶酸介导的细胞内化而进入细胞.%Objective To investigate the tumor ceils binding mechanism of the long-circulating liposomes loading docetaxel mediated by folic acid receptor(FoI-PEG-DTXL). Methods In this study, the long-circulating liposomes loading docetaxel mediated by folic acid receptor were prepared by conventional rotary-evaporated film-ultrasonication method. The flow cytometer and fluorescence microscopy were used to investigate the binding efficacy of FoI-PEG-DTXL against MCF-7 cells and Hela cells. Results After incubated with FoI-PEG-DTXL, the binding amount on MCF-7 cells was higher than that on Hela cells. The binding of Fol-PEG-DTXL could be inhabited by the addition of the free folic acid. Furthermore, a bright green fluorescence was observed on the MCF-7 cells, and the not clear green fluorescence was found on the Hela cells.Conclusions The liposomes are internalized into cells mediated by folic acid.

  18. Dementia worry and its relationship to dementia exposure, psychological factors, and subjective memory concerns.

    Science.gov (United States)

    Kinzer, Adrianna; Suhr, Julie A

    2016-01-01

    With increased societal awareness of dementia, older adults show increased concern about developing dementia, leading to misidentification of aging-related cognitive glitches as signs of dementia. While some researchers have suggested self-reported cognitive concerns accurately identify older adults with early signs of dementia, there is evidence that subjective cognitive decline is not associated with objective cognitive performance and instead reflects psychological factors consistent with models of health anxiety, including dementia worry. We examined the construct of dementia worry and its relationship to subjective memory concerns in 100 older adults (Mage = 69 years) without signs of dementia, using a recently developed measure of dementia worry. Consistent with hypotheses, dementia worry was related to exposure to dementia, having a high number of depressive or general worry symptoms, and having more memory concerns. Exposure to dementia moderated the relationship of dementia worry to depression and general worry. Furthermore, dementia worry moderated the relationship of objective memory impairment to subjective memory ratings. The results provide further evidence of the role of psychological factors such as dementia worry in subjective memory report and emphasize the need for objective cognitive testing before making determinations about dementia in older adults expressing memory concerns. PMID:26496236

  19. Concern about HIV and AIDS among older people in the slums of Nairobi, Kenya.

    Science.gov (United States)

    Chepngeno-Langat, Gloria; Falkingham, Jane C; Madise, Nyovani J; Evandrou, Maria

    2012-09-01

    The article explores the way that social networks and personal experiences affect perceived HIV-related concerns among people aged 50 years or older living in a low resource neighborhood with high HIV prevalence in Nairobi, Kenya. Multiple logistic regression is used to model the association between the reporting of an HIV-related concern and individual-level characteristics, personal experiences, and social interaction. The main concerns regarding HIV reported by older people in the study included caring for orphaned children (65%), caring for people with AIDS (48%), and losing material and social support from adult children (36%). Interestingly, 38% of respondents voiced concerns about HIV infection among older people. Respondents who had been individually affected by HIV and AIDS, who were part of a wide social network, or who participated in community activities were frequently more likely to report a concern. The findings highlight the significance of the role of social interaction and social networks in the diffusion of information and knowledge. These findings have implications for HIV and AIDS policy and programs, highlighting the potential for social networks and community-level interventions to educate and increase awareness about HIV and AIDS among older people. Community leaders can make good peer educators and communication agents for HIV/AIDS campaigns. Additionally, the recognized high level of personal vulnerability to HIV infection among older people suggests the need for targeted sexual behavior change programs among this often neglected group. PMID:22324649

  20. Exploring host-guest complexation mechanisms by a molecular dynamics/quantum mechanics/continuum solvent model approach

    Science.gov (United States)

    Ye, Renlong; Nie, Xuemei; Zhou, Yumei; Wong, Chung F.; Gong, Xuedong; Jiang, Wei; Tang, Weihua; Wang, Yan A.; Heine, Thomas; Zhou, Baojing

    2016-03-01

    We introduce a molecular dynamics/quantum mechanics/continuum solvent model (MD/QM/CSM) approach to investigate binding mechanisms of host-guest systems. The representative conformations of host, guest, and their complex generated from MD simulations at the molecular-mechanics level are used for binding free energy calculations based on a QM/CSM model. We use this approach to explore the binding mechanisms of β-cyclodextrin (β-CD) and 2, 6-di-methyl-β-CD (DM-β-CD) with various guest molecules. Our results suggest that solvent effects play a more important role in determining the relative binding affinities of DM-β-CD than those of β-CD mainly because the former is more flexible than the latter.

  1. A concern-based method to prioritize spill response activities

    International Nuclear Information System (INIS)

    The Shoreline Cleanup Assessment Team (SCAT) of the Emergencies Division of Environment Canada in the Ontario Region developed a computerized method to help rank segments of shoreline according to levels of concern in the event of an oil spill. The original SCAT approach was designed to allow survey teams to acquire information about the state of shoreline spills so that assessments of oilings would be comparable in time and space. The SCAT method, which allows several decision makers to obtain an unbiased evaluation of the oiling situation, has been recognized in both Canada and the United States as a method that ensures the consistency of data gathering and processing for prioritization purposes. The concern-based prioritization system was integrated within the computerized response tools used by the SCAT team using tools such as the Great Lakes Electronic Environmental Sensitivities Atlas (GLEESA), a geographic information system (GIS) of environmental data, and Shore Assess, a GIS based computerized system used to provide support during a response phase of a spill. It was noted that this method is considered to be a practical response tool designed around the principles of performance support and cybernetics to help decision makers set priorities. It is not designed for pre-impact assessment. Instead, it ensures that existing knowledge of the spill characteristics and environmental conditions are used in a consistent and logical method to prioritize contingency plans. The factors used to evaluate concern for oiling, shoreline type and land use were described. Factors for concern assessment of biological organisms include the status of organisms as being either endangered, threatened, vulnerable, special concern, or not at risk. Characteristics of the species, potential effect of the pollutant and potential effect from response activities are other factors for concern. The method evaluates the concern for every category using a simple algorithm which is

  2. Understanding Going Concern in Auditing: Seker Poultry, Inc.

    Directory of Open Access Journals (Sweden)

    Ayca Zeynep Suer

    2016-02-01

    Full Text Available Under the going concern assumption, an entity is viewed as continuing in business for the foreseeable future. General purpose financial statements are prepared on a going concern basis, unless management either intends to liquidate the entity or to cease operations, or has no realistic alternative but to do so. In this case study, we examine the recent financial problems of Seker Poultry, Inc. – one of the listed companies in Borsa Istanbul –and their impacts on the financial statement audit process. This case provides an opportunity to examine the auditor‘s judgment process and responsibilities regarding the going concern assumption. This case uses information in Seker‘s recent publicly available financial statements and annual reports. The case can be used in undergraduate or graduate level audit courses.

  3. CEO Interests and Concerns in Second Wave ERP

    DEFF Research Database (Denmark)

    Simonsen, Martin Lyngaa; Nielsen, Esben Toftdahl; Kræmmergaard, Pernille

    2006-01-01

    This paper is the product of a study of what top management find interesting and what is of concern to them in relation to the Enterprise Resource Planning (ERP) systems in the second wave of ERP. Very little empirical research exists on the subject of the interests and concerns of CEOs in relation...... to a company's ERP System. However research into information system literature indicates that CEOs are valued as key players in the management of IT to secure that the IT strategy is aligned with the business strategy. Based on the fact that very little prior research exists on the CEOs' interests...... and concerns in relation to the ERP system in the second wave, we employed an interpretive explorative case study with a grounded approach carried out through open interviews with CEOs. The research was conducted in three mid-size Danish production companies all of which have an ERP system. The...

  4. Food shopping and weight concern. Balancing consumer and body normality

    DEFF Research Database (Denmark)

    Nielsen, Annemette; Holm, Lotte

    2014-01-01

    The desire to achieve a normal, culturally acceptable body is often seen as the main driver of food-consumption practices adopted by individuals who are concerned about their body weight. In social research into weight management self-control is therefore often a central theme. Turning the focus...... towards practices and values related to food shopping, this study adds to our understanding of central features in perceptions of normality among people with weight concerns. In a qualitative study 25 people who participated in a dietary intervention trial in Denmark were interviewed and five people were......, practices and experiences of controlling food intake. The paper suggests that freedom and control are composite and complementary ideals of normality for people with weight concerns. On the basis of this insight, the authors discuss the contribution the paper makes to existing studies of weight management...

  5. Intellectually disabled students’ conceptions concerning the earth and heavenly bodies

    Directory of Open Access Journals (Sweden)

    Engin Baysen

    2014-08-01

    Full Text Available Learning scientific concepts are crucial for both normally achieving and intellectually disabled students attending inclusion classes. This research study aimed to reveal intellectually disabled students’ conceptions and thinkings utilizing data of interviews and drawings concerning the earth and heavenly bodies and comparing them with the findings belonging to those showing normal mental achievement. Thirty intellectually disabled students (19 boys and 11 girls participated to this research. They were questioned individually using clinical interview technique. Intellectually disabled students have main similarities to those of normally achieving concerning the phenomenon. All the students participating in the present research study do have misconceptions concerning the phenomenon. Their thinking approaches (tendencies and the way they are affected by certain context while constructing their conceptions is similar to those of normally achieving. They used their concepts consistently and showed theory-like mental constructions.

  6. Concern over Zika virus outbreak: another alarming global threat

    Science.gov (United States)

    Hafiz, Muhammad Yusuf; Mahmood, Syed Uzair; Shoaib, Maria; Yusuf, Farah Hafiz

    2016-01-01

    Zika virus, as highlighted by the World Health Organization in February 2016, has emerged as a public health emergency of international concern. Zika virus is enveloped and icosahedral, and has a nonsegmented, single-stranded, positive-sense RNA genome. It belongs to Flaviviridae family. Aedes aegypticus mosquito is the known vector. Transmission is anthroponotic (human to vector to human) during outbreaks, or occurs perinatally in utero, sexually, and via transfusion of infected blood. Zika virus is turning out to be a major public health concern. Not only has it shown dramatic teratogenic association and caused serious neurological concerns but it has also spread around the globe. Countries that have not yet been affected by Zika virus should adopt proper preventive methods to limit its spread in the population. PMID:27418843

  7. An Overview Of The Security Concerns In Enterprise Cloud Computing

    Directory of Open Access Journals (Sweden)

    Anthony Bisong

    2011-01-01

    Full Text Available Deploying cloud computing in an enterprise infrastructure bring significant security concerns.Successful implementation of cloud computing in an enterprise requires proper planning andunderstanding of emerging risks, threats, vulnerabilities, and possible countermeasures. We believe enterprise should analyze the company/organization security risks, threats, and available countermeasures before adopting this technology. In this paper, we have discussed security risks and concerns in cloud computing and enlightened steps that an enterprise can take to reduce security risksand protect their resources. We have also explained cloud computing strengths/benefits, weaknesses, and applicable areas in information risk management.

  8. Contradictions in climate concern: Performances of home and away

    OpenAIRE

    Cohen, SA; Higham, JES

    2012-01-01

    There is a burgeoning body of academic literature (e.g. Becken, 2007; Gössling et al, 2006; Hares et al, 2010) that examines if and how consumer concern about climate change manifests itself in tourist behavioural practices. These works build on a wealth of previous studies that consider how consumer concern over issues of sustainable development may also affect tourist behaviour. Indeed, whilst tourism’s climate impacts have lately been a hot topic, there is no doubt that issues of climate c...

  9. A Review of Universal Grammar Concerning Second Language Acquisition Research

    Institute of Scientific and Technical Information of China (English)

    李倩

    2014-01-01

    Chomsky’s Universal Grammar (UG) theory not only answers“the logical problem of language acquisition”, but also provides insights and thoughts for second language acquisition (SLA) research on both theoretical and empirical level. However, there are many problems of UG-based research. On the theoretical aspect, UG-based approach left untouched many areas apart from“core grammar”and the continual development of the theory is problematic to second language researchers. On the empiri-cal aspects, most experiments reveal problems with the design and data collection process. In short, the evaluation of UG concern-ing SLA should be developmental and comprehensive.

  10. Construct validity of the Concern For Appropriateness scale.

    Science.gov (United States)

    Cutler, B L; Wolfe, R N

    1985-06-01

    Construct validity of the Concern For Appropriateness scale (CFA; Lennox & Wolfe, 1984), a measure of the tendency to adopt protective self-presentation styles, is examined using a multitrait-multimethod approach. Self-ratings on the CFA and ratings by suitemates constitute the two methods, and concern for appropriateness, interpersonal trust, and boredom susceptibility are assessed with each. Multitrait-multimethod analysis shows that the CFA scale exhibits convergent validity against peer ratings and discriminant validity against boredom susceptibility, the only other variable demonstrating convergence. Results indicate that the CFA exhibits construct validity and might therefore prove useful as an operationalization for self-presentation tendencies. PMID:16367476

  11. An Overview of the Security Concerns in Enterprise Cloud Computing

    CERN Document Server

    Bisong, Anthony; Rahman, M; 10.5121/ijnsa.2011.3103

    2011-01-01

    Deploying cloud computing in an enterprise infrastructure bring significant security concerns. Successful implementation of cloud computing in an enterprise requires proper planning and understanding of emerging risks, threats, vulnerabilities, and possible countermeasures. We believe enterprise should analyze the company/organization security risks, threats, and available countermeasures before adopting this technology. In this paper, we have discussed security risks and concerns in cloud computing and enlightened steps that an enterprise can take to reduce security risks and protect their resources. We have also explained cloud computing strengths/benefits, weaknesses, and applicable areas in information risk management.

  12. Health concerns and ethical considerations regarding international surrogacy.

    Science.gov (United States)

    Knoche, Jonathan W

    2014-08-01

    Since the advent of IVF, various arrangements for child bearing and rearing have developed. With the confluence of advanced medical technology, reproductive choice, and globalization, a market in international surrogacy has flourished. However, myriad health, social, and ethical concerns abound regarding the well-being of gestational carriers and children, the infringement of autonomy and free choice, and threats to human dignity. The present paper examines the scope, health risks, and ethical concerns of cross-border surrogacy, arguing that the risks may not exceed the benefits. PMID:24834850

  13. Hydraulic "fracking": are surface water impacts an ecological concern?

    Science.gov (United States)

    Burton, G Allen; Basu, Niladri; Ellis, Brian R; Kapo, Katherine E; Entrekin, Sally; Nadelhoffer, Knute

    2014-08-01

    Use of high-volume hydraulic fracturing (HVHF) in unconventional reservoirs to recover previously inaccessible oil and natural gas is rapidly expanding in North America and elsewhere. Although hydraulic fracturing has been practiced for decades, the advent of more technologically advanced horizontal drilling coupled with improved slickwater chemical formulations has allowed extensive natural gas and oil deposits to be recovered from shale formations. Millions of liters of local groundwaters are utilized to generate extensive fracture networks within these low-permeability reservoirs, allowing extraction of the trapped hydrocarbons. Although the technology is relatively standardized, the geographies and related policies and regulations guiding these operations vary markedly. Some ecosystems are more at risk from these operations than others because of either their sensitivities or the manner in which the HVHF operations are conducted. Generally, the closer geographical proximity of the susceptible ecosystem to a drilling site or a location of related industrial processes, the higher the risk of that ecosystem being impacted by the operation. The associated construction of roads, power grids, pipelines, well pads, and water-extraction systems along with increased truck traffic are common to virtually all HVHF operations. These operations may result in increased erosion and sedimentation, increased risk to aquatic ecosystems from chemical spills or runoff, habitat fragmentation, loss of stream riparian zones, altered biogeochemical cycling, and reduction of available surface and hyporheic water volumes because of withdrawal-induced lowering of local groundwater levels. The potential risks to surface waters from HVHF operations are similar in many ways to those resulting from agriculture, silviculture, mining, and urban development. Indeed, groundwater extraction associated with agriculture is perhaps a larger concern in the long term in some regions. Understanding the

  14. Managing nuclear knowledge: A SCK-CEN Concern

    International Nuclear Information System (INIS)

    Full text: Managing knowledge can be seen as the processes governing the creation, the dissemination and the utilisation of knowledge. Any organisation and specially a research centre will need a continuously updated body of knowledge as a basis of its sustained existence. Since its very beginning, SCK-CEN has always been a knowledge-based organisation aiming to solve topical problems based on experiences in the field, model-oriented experiments and fundamental research. Preserving and enhancing our institutional memory has become vital for the SCK-CEN. We are therefore pursuing our efforts to stimulating preservation and sharing of Nuclear Knowledge. Our knowledge exists in different forms and formats ranging from dispersed pieces of technical or scientific information on different media to a complex reservoir of people with the required educational background, expertise and acquired insights to apply that knowledge safely and effectively. SCK-CEN decided in 2001 to tackle this strategic concern by adopting a practical knowledge management (KM) approach. Our programme started in 2002 is built on 'what already exists'. KM activities were identified all over our organisation - building databases, assembling nuclear and technical information, implementing QA procedures, conducting training, writing publications - so that every researcher or technical staff can lay claim to it. However, a coordinated approach to Knowledge Management requires an efficient re-use of the recorded knowledge and an effective transfer of the available knowledge. This approach ensures an added value to our research work and guarantees on the long term the preservation of our institutional memory. The objective of the KM programme is the continuous improvement of the information management coupled with the elicitation of tacit knowledge, the stimulation of collaboration and the knowledge transfer. KM also enhances the information objects by adding or linking related additional information and

  15. Exploring domestic energy-saving: The role of environmental concern and background variables

    International Nuclear Information System (INIS)

    The main purpose of this paper is to investigate whether residents' environmental concern has any effect on their energy-saving curtailments and efficiency investments. The novelty of the present work lies in the fact that it seeks to investigate this topic in a multi-country setting, exploiting data from nine OECD countries (Australia, Canada, Czech Republic, France, Italy, South Korea, Netherlands, Norway and Sweden), and also in that it employs a latent variable model which allows us to examine the conditions necessary for the results to be comparable across different countries. Novel in this paper is also the focus on the role of environmental concern as a factor of several curtailments and efficiency investments. Our results suggest that people with higher environmental concern are on average more likely to perform energy-saving curtailments and also are more likely to have some energy-efficiency retrofits installed in dwellings. Most of the socio-economic and demographic variables have mixed effects on efficiency investments and curtailments. However, some interesting patterns emerged with respect to the age of respondents, household income, education and gender of respondents, and also the size of household. - Highlights: ► People with higher environmental concern are more likely to perform energy-saving curtailments. ► People with higher environmental concern are more likely to introduce some energy efficiency retrofits. ► Older people are more concerned about environmental problems, invest in efficiency and curtail more. ► Formal level of education does not play prominent role with respect to domestic energy-saving. ► Wealthier people are more likely to invest in energy efficiency but less likely to curtail.

  16. Statistical Approaches Concerning the Relationship between the Health Index and the Life Expectancy, in Romania

    Directory of Open Access Journals (Sweden)

    Gabriela Opait

    2015-09-01

    Full Text Available This research reflects the methodology for to achieve the statistical modeling of the trend concerning the correlation between the Health Index and the Life Expectancy in Romania, in the period 2005-2014. with the help of the „Least Squares Method”, which is a method through we can to express the trend line of the best fit concerning a model. Also, this paper reflects the manner in which we can to measure the intensity regarding the correlation between the Health Index and the Life Expectancy in Romania, between 2005-2014 with the help of the Correlation Raport and how we can to reflect that there is a significant diferrence between the values of the Health Index in Romania and the values of the Health Index in U.S.A., respectively the values of the Health Index in Norway by means of the T test.

  17. Concern With Environmental Deterioration and Attitudes Toward Population Limitation

    Science.gov (United States)

    Barnett, Larry D.

    1970-01-01

    Analysis of Gallup Poll data of Junuary 1969 reveals weak association between concern about environmental deterioration and the recognition of need for eventual limitation of human population. Suggests that to increase favorable attitudes to population control, role of overpopulation in causing environmental deterioration needs to be presented to…

  18. 42 CFR 422.2260 - Definitions concerning marketing materials.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Definitions concerning marketing materials. 422.2260 Section 422.2260 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2260 Definitions...

  19. 42 CFR 423.2260 - Definitions concerning marketing materials.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Definitions concerning marketing materials. 423.2260 Section 423.2260 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Part D Marketing Requirements § 423.2260...

  20. 10 CFR 51.67 - Environmental information concerning geologic repositories.

    Science.gov (United States)

    2010-01-01

    ... law, the Department of Energy may be required to supplement its final environmental impact statement... 10 Energy 2 2010-01-01 2010-01-01 false Environmental information concerning geologic repositories. 51.67 Section 51.67 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL...

  1. Death Concerns among Individuals Newly Diagnosed with Lung Cancer

    Science.gov (United States)

    Lehto, Rebecca; Therrien, Barbara

    2010-01-01

    Confronting the reality of death is an important challenge for individuals facing life-threatening illness such as lung cancer, the leading cause of cancer death. Few studies, however, document the nature of death-related concerns in individuals newly diagnosed with lung cancer. The aims of this exploratory study were to examine unsolicited…

  2. SUPPLY REORGANIZATION IN THE SOUTHERN POLAND POWER CONCERN

    OpenAIRE

    Janusz Grabara

    2008-01-01

    The paper presents problems of procurement and supply materials to power plants in case of merger of a few plant in one power concern. The author present the analysis of present situation and proposals of supply reorganization considering technical and organizational problems.

  3. Farmers' Concerns: A Qualitative Assessment to Plan Rural Medical Education

    Science.gov (United States)

    Anderson, Brittney T.; Johnson, Gwendolyn J.; Wheat, John R.; Wofford, Amina S.; Wiggins, O. Sam; Downey, Laura H.

    2012-01-01

    Abstract Context: Limited research suggests that translational approaches are needed to decrease the distance, physical and cultural, between farmers and health care. Purpose: This study seeks to identify special concerns of farmers in Alabama and explore the need for a medical education program tailored to prepare physicians to address those…

  4. Exposition concerning small windmills. Appendix to main report. Volume 1

    International Nuclear Information System (INIS)

    This appendix to the main report entitled ''Exposition Concerning Small Windmills'' includes background information on the report, profiles of the participating companies and of those visited in Denmark and abroad, questionnaires and interview schemes sent to the participating companies, surveys of producers of Danish and foreign producers of small windmills and an appendix to the economical calculations found within the report. (AB)

  5. Personality Features and Expressed Concerns of Adolescents with Eating Disorders.

    Science.gov (United States)

    Pryor, Tamara; Wiederman, Michael W.

    1998-01-01

    Investigates differences between adolescent females diagnosed with either anorexia nervosa (n=26) or bulimia nervosa (n=30) using the Millon Adolescent Personality Inventory. About half of the participants displayed an inhibited personality style. Anorexics scored higher on the Respectful personality scale. Expressed concerns over self-concept,…

  6. Teachers' Concerns about Inclusive Education in Ahmedabad, India

    Science.gov (United States)

    Shah, Rina; Das, Ajay; Desai, Ishwar; Tiwari, Ashwini

    2016-01-01

    This study was undertaken to determine the concerns of primary school teachers about the inclusion of students with disabilities in Ahmedabad, India. A total of 560 teachers, working in government-run schools, returned the completed survey. A two-part questionnaire was used in this study. Part 1 gathered information relating to personal and…

  7. Perceptions of Pharmacy Students Concerning Cancer Pain and Its Treatment.

    Science.gov (United States)

    Holdsworth, Mark T.; Raisch, Dennis W.

    1993-01-01

    A survey of 62 third- and 105 fourth-year pharmacy students found a number of misperceptions concerning cancer pain and its management that may translate into inadequate provision of care to future patients. Research on educational strategies to address these misperceptions is recommended. (Author/MSE)

  8. Concern over ready-to-eat breakfast cereals

    Science.gov (United States)

    The Research and Professional Brief published in the April 2008 issue of the Journal entitled "Examining the Nutritional Quality of Breakfast Cereals Marketed to Children" (1) is of concern. The authors concluded that the "the majority of children's cereals failed to meet national nutrition standard...

  9. On some problems concerning the national emergency planning

    International Nuclear Information System (INIS)

    The basic principles of national emergency planning and preparedness in case of severe nuclear accident are discussed. Recommendations concerning the participating authorities in Bulgaria and their cooperation are given. The need to synchronize the plan with the NPP Kozloduy emergency plan is pointed out. The introduction of new legislation outlining the necessity of national emergency planning is stressed. 13 refs

  10. General Practitioners' Knowledge and Concern about Electromagnetic Fields

    DEFF Research Database (Denmark)

    Berg-Beckhoff, Gabriele; Breckenkamp, Jürgen; Larsen, Pia Veldt;

    2014-01-01

    Our aim is to explore general practitioners' (GPs') knowledge about EMF, and to assess whether different knowledge structures are related to the GPs' concern about EMF. Random samples were drawn from lists of GPs in Germany in 2008. Knowledge about EMF was assessed by seven items. A latent class ...

  11. CURRENT CONCERNS REGARDING THE CORPORATE SOCIAL RESPONSIBILITY IN ROMANIA

    OpenAIRE

    IONELA CARMEN PIRNEA; NICOLETA BELU; EMILIA IORDACHE

    2012-01-01

    The propose of this paper is to identify current concerns regarding the corporate social responsibility in Romania. First the paper present a short introduction about the concept of corporate social responsibility. Next the paper highlights the importance of corporate social responsibility in Romania and some results about the involvement of small and medium enterprises in social responsibility activities.

  12. Radiation dose - the marine environment, a cause for concern

    International Nuclear Information System (INIS)

    The paper is concerned with the disposal of radioactivity into a marine environment, and the risks associated with a radiation dose to the general public. The Black report and the Holliday report are discussed; as well as risk factors, radiological protection, the recommendations of the International Commission on Radiological Protection, and marine disposal of radionuclides. (U.K.)

  13. Teratogenicity and the Threshold of Toxicological Concern concept

    NARCIS (Netherlands)

    Schothorst F van; Piersma AH; TOX

    2003-01-01

    The Threshold of Toxicological Concern (TTC) is a principle that refers to the possibility of establishing a human exposure threshold value for all chemicals below which there is no significant risk to human health. The threshold value is primarily based on carcinogenesis data. For other potentiall

  14. 28 CFR 12.4 - Inquiries concerning application of act.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Inquiries concerning application of act. 12.4 Section 12.4 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS... submitted, including the identity of the person on whose behalf the inquiry is made, the facts which...

  15. 28 CFR 51.29 - Communications concerning voting changes.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Communications concerning voting changes. 51.29 Section 51.29 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE... individual that his or her identity not be disclosed to any person outside the Department, to the...

  16. Exploring the health concerns of people taking methadone

    LENUS (Irish Health Repository)

    James, P

    2012-01-01

    This article reports on a study to uncover the health concerns of clients attending a methadone maintenance programme in an addiction service in Ireland. This is an extended version of the article published in Nursing Times; 104: 35, 26–27.

  17. Care and Concern: An Ethical Journey in Participatory Action Research.

    Science.gov (United States)

    Stuart, Carol A.

    1998-01-01

    Reviews the four basic principles of an ethical framework as outlined by the Code of Ethical Conduct for Research Involving Humans in light of the requirements of a participatory action research approach. Discusses the ethics of participatory action research in regard to care and concern. Argues that the ethics of morality and justice are…

  18. Helping Behavior, Dispositional Empathic Concern, and the Principle of Care

    Science.gov (United States)

    Wilhelm, Mark Ottoni; Bekkers, Rene

    2010-01-01

    This research investigates the relative strength of two correlates of helping behavior: dispositional empathic concern and a moral principle to care about others. The empathy-helping and care-helping relationships are investigated using data from the General Social Survey, a nationally representative random sample of the U.S. adult population. Ten…

  19. A Face Concern Approach to Conflict Management A Malaysian Perspective

    OpenAIRE

    Raduan C. Rose; Waitchalla R. Suppiah; Jegak Uli; Jamilah Othman

    2006-01-01

    This study presents a review of conflict management from a face concern approach. It presents the various definitions on conflict and types of conflict. It further looks at how face negotiation theory explains the use of various conflict management styles in individualist and collectivist cultures. In addition, it provides some insight into conflict management from a Malaysian perspective.

  20. From Eradication to Resistance: Five Continuing Concerns About Pediculosis.

    Science.gov (United States)

    Brainerd, Elaine

    1998-01-01

    Discusses the five major concerns that govern a school nurse's thinking in managing head louse infestations, including dispelling misconceptions about head lice; ensuring that infestations are not missed; ensuring that parents understand instructions for effective treatment; educating the community about the correct use of pediculicides; and…

  1. Identifying the Key Concerns of Irish Persons with Intellectual Disability

    Science.gov (United States)

    García Iriarte, Edurne; O'Brien, Patricia; McConkey, Roy; Wolfe, Marie; O'Doherty, Siobhain

    2014-01-01

    Background: Internationally, people with intellectual disability are socially marginalized, and their rights under the United Nations Convention for the Rights of Persons with Disabilities (CRPD) are often ignored. Aims: This paper aims to define the key concerns of adults with an intellectual disability in relation to their participation in…

  2. Tailwater concerns and the history of turbine aeration

    International Nuclear Information System (INIS)

    All new proposals for hydropower development and many of the almost 300 hydroelectric projects which will be relicensed before 2000 will have to address the issue of minimum dissolved oxygen concentrations. This paper highlights some of the causes and concerns of low dissolved oxygen concentrations in releases from hydropower projects and describes the history of hydroturbine aeration for reaerating these releases

  3. Some results concerning the external photoelectric effect and secondary emission

    International Nuclear Information System (INIS)

    The characteristics and limiting possibilities of the various constituent parts of a photoelectric detector are considered. Two methods for illuminating the cathode are described and discussed. The few scattered results concerning the maximum output of cathodes and dynodes are collected together and a tentative explanation is put forward. A comparison is made of three methods for measuring very low light fluxes. (author)

  4. Perceptions Concerning College Student Suicide: Data from Four Universities

    Science.gov (United States)

    Westefeld, John S.; Homaifar, Beeta; Spotts, Jennifer; Furr, Susan; Range, Lilian; Werth, James L., Jr.

    2005-01-01

    The issue of suicide, including prevention, intervention, and postvention, continues to be a problem on college campuses. For this study, data concerning a variety of issues related to college student suicide were collected from 1,865 students at four different universities. Incidence, risk factors, and potential solutions are described, as well…

  5. CURRENT CONCERNS REGARDING THE CORPORATE SOCIAL RESPONSIBILITY IN ROMANIA

    Directory of Open Access Journals (Sweden)

    IONELA CARMEN PIRNEA

    2012-11-01

    Full Text Available The propose of this paper is to identify current concerns regarding the corporate social responsibility in Romania. First the paper present a short introduction about the concept of corporate social responsibility. Next the paper highlights the importance of corporate social responsibility in Romania and some results about the involvement of small and medium enterprises in social responsibility activities.

  6. Occurrence of Medical Concerns in Psychiatric Outpatients with Intellectual Disabilities

    Science.gov (United States)

    Azimi, Kousha; Modi, Miti; Hurlbut, Janice; Lunsky, Yona

    2016-01-01

    Despite the fact that adults with both intellectual disabilities (ID) and psychiatric disorders are at increased risk for physical health problems, few studies have described their medical concerns specifically. This study reports on the rates of physical health issues and completion of recommended health screenings among 78 adult outpatients with…

  7. Students' Evaluation of Teaching: Concerns of Item Diagnosticity

    Science.gov (United States)

    Madden, Thomas J.; Dillon, William R.; Leak, Roland L.

    2010-01-01

    The validity and reliability of students' evaluation of teaching effectiveness has been debated since the 1970s. One concern is the extent to which the ratings are influenced by halo, and if so, how does halo affect the interpretation of the ratings? This study seeks to assess the degree to which the halo affects the diagnosticity of individual…

  8. Environmental Health concerns in natural and man-made environments

    Science.gov (United States)

    Bergtholdt, C. P.

    1975-01-01

    Industrial hygene and environmental health aspects of ground operation at the Jet Propulsion Laboratory were investigated. Major areas of concern are: (1) toxic substances, (2) noise pollution, (3) electromagnetic radiation; and (4) biohazards and sanitation. Each of these categories are also studied in a closed environment, such as encountered aboard of a spacecraft.

  9. Teachers' Perceptions, Beliefs and Concerns about Cyberbullying

    Science.gov (United States)

    Eden, Sigal; Heiman, Tali; Olenik-Shemesh, Dorit

    2013-01-01

    Schools and teachers nowadays face new difficulties and challenges as a result of the fast growth of cyberbullying. The aim of the study is to examine the perceptions, beliefs and concerns about cyberbullying, as well as the needs, of a professionally diverse group of teachers. Three-hundred and twenty-eight teachers (88.4% female, 11.6% male)…

  10. "Peer Pressure" and the Group Process: Building Cultures of Concern

    Science.gov (United States)

    Tate, Thomas F.; Copas, Randall L.

    2010-01-01

    Peer group treatment has been subject to two main lines of criticism. Some suggest any program which aggregates antisocial youth inevitably fosters negative peer influence. Others are concerned that certain peer programs are based on coercive peer confrontation. Positive Peer Culture [PPC] is an antidote to both of these varieties of toxic group…

  11. Adolescent Social Issues: Using Media to Address Crucial Concerns.

    Science.gov (United States)

    Sokoloff, Michele

    1987-01-01

    This article describes media resources available to help adolescents deal with a variety of social concerns, including substance abuse, dropouts, Acquired Immune Deficiency Syndrome (AIDS), suicide, and pregnancy. A list of 56 companies that provide resources dealing with social issues is also provided. (LRW)

  12. Asset retirement obligations: a reporting concern for healthcare facilities.

    Science.gov (United States)

    Berg, Gary G; Bayes, Paul E; Morgan, Robert G

    2008-11-01

    FASB statements and SEC guidelines give direction as to how healthcare organizations should account for their asset retirement obligations (AROs) where environmental issues are concerned. A key consideration is that current costs associated with environmental problems, such as encapsulating asbestos, are to be accounted for as part of an asset's cost and depreciated over the asset's remaining life. PMID:18990844

  13. Identification of 300 Area Contaminants of Potential Concern for Soil

    Energy Technology Data Exchange (ETDEWEB)

    R.W. Ovink

    2010-04-05

    This report documents the process used to identify source area contaminants of potential concern (COPCs) in support of the 300 Area remedial investigation/feasibility study (RI/FS) work plan. This report also establishes the exclusion criteria applicable for 300 Area use and the analytical methods needed to analyze the COPCs.

  14. Predictors of Changes in Body Image Concerns of Chinese Adolescents

    Science.gov (United States)

    Chen, Hong; Jackson, Todd

    2009-01-01

    This nine-month prospective study tested the extent to which risk factors implicated in recent accounts of body dissatisfaction predicted changes in body image concerns of adolescent boys and girls in China. A sample of 593 Chinese adolescents (217 boys, 376 girls) completed measures of weight esteem, appearance esteem and physical stature concern…

  15. Sociocultural Influences on Body Image Concerns of Young Chinese Males

    Science.gov (United States)

    Jackson, Todd; Chen, Hong

    2008-01-01

    This research assessed the extent to which sociocultural factors implicated in explanations of weight dissatisfaction among young Western females extend to sources of body image concern in emerging adult and adolescent males from the People's Republic of China. In Study 1, 219 Mainland Chinese male university students completed measures of stature…

  16. The Affective Consequences of Minimizing Women's Body Image Concerns

    Science.gov (United States)

    Bosson, Jennifer K.; Pinel, Elizabeth C.; Thompson, J. Kevin

    2008-01-01

    We propose that women regularly anticipate and receive messages from others that trivialize the severity of their body image concerns. Moreover, we suggest that these minimizing messages can heighten women's negative affective reactions to body image threats, particularly if they internalize them. Two studies provided support for these ideas. In…

  17. Activities of the Environmental Protection Agency concerning phthalate esters

    OpenAIRE

    Newburg-Rinn, Steven D.

    1982-01-01

    EPA's activities concerning phthalate esters have been in four general areas, namely: (1) their status as toxic pollutants under the Clean Water Act; (2) their status as “new chemicals” under Section 5 of TSCA; (3) the potential risk to human beings posed by DEHP; and (4) finally, the need for testing phthalates with respect to their health and environmental effects.

  18. Four issues concerning colour constancy and relational colour constancy

    NARCIS (Netherlands)

    Foster, DH; Nascimento, SMC; Craven, BJ; Linnell, KJ; Cornelissen, FW; Brenner, E

    1997-01-01

    Four issues concerning colour constance and relational colour constancy are briefly considered: (I) the equivalence of colour constancy and relational colour constancy; (2) the dependence of relational colour constancy on ratios of cone excitations due to light from different reflecting surfaces, an

  19. Digital Competence: general problems and experimental practices concerning highschools

    OpenAIRE

    Roberto Gris

    2015-01-01

    In the current social context Information and Communication Technologies (ICT) are more and more present and pervasive and the European institutions enter the Digital Competence in the Key Competences for Lifelong Learning. In this focus we are deepened the general problems of Digital Competence and competence-based education and to describe experimental practices concerning highschools.

  20. Directory of National Organizations Concerned With Land Pollution Control.

    Science.gov (United States)

    Freed Publishing Co., New York, NY.

    Included in this directory are 133 national organizations, agencies, institutes and/or private groups concerned with the reduction or prevention of land pollution. Arranged in alphabetical order, each annotation gives the complete name of the organization, its address, telephone number, person to contact, and a short description of the scope of…

  1. Directory of National Organizations Concerned with Land Pollution Control, 1971.

    Science.gov (United States)

    Freed Publishing Co., New York, NY.

    Included in this directory are 204 national organizations, agencies, institutes, and/or private groups concerned with the reduction or prevention of land pollution. Arranged in alphabetical order, each annotation gives the complete name of the organization, its address, telephone number, person to contact, and a short description of the scope of…

  2. College Student Concerns: Perceptions of Student Affairs Practitioners

    Science.gov (United States)

    Reynolds, Amy L.

    2013-01-01

    The purpose of this study was to increase awareness of the perceptions of student affairs professionals regarding the most frequent and challenging concerns facing college students today. Using the Delphi method, 159 entry-level and mid-level student affairs administrators from institutions across the country were surveyed about their perceptions…

  3. Future Elementary School Teachers' Conceptual Change Concerning Photosynthesis

    Science.gov (United States)

    Ahopelto, Ilona; Mikkila-Erdmann, Mirjamaija; Anto, Erkki; Penttinen, Marjaana

    2011-01-01

    The purpose of this study was to examine conceptual change among future elementary school teachers while studying a scientific text concerning photosynthesis. Students' learning goals in relation to their learning outcomes were also examined. The participants were future elementary school teachers. The design consisted of pre- and post-tests. The…

  4. Awareness, Knowledge, and Concern about Age-Related Macular Degeneration

    Science.gov (United States)

    Cimarolli, Verena R.; Laban-Baker, Allie; Hamilton, Wanda S.; Stuen, Cynthia

    2012-01-01

    Age-related macular degeneration (AMD)--a common eye disease causing vision loss--can be detected early through regular eye-health examinations, and measures can be taken to prevent visual decline. Getting eye examinations requires certain levels of awareness, knowledge, and concern related to AMD. However, little is known about AMD-related…

  5. Review of WHO/PAHO/IAEA recommendations concerning radiotherapy facilities

    International Nuclear Information System (INIS)

    Since the mid 1960s the World Health Organization, the Pan American Health Organization, and the International Atomic Energy Agency have provided recommendations concerning radiotherapy services, including organization, staff requirements and facilities. These are contained in various reports of WHO, PAHO and IAEA, which are reviewed and summarized. (author). 9 refs

  6. Extended Care Programs in Catholic Schools: Some Legal Concerns.

    Science.gov (United States)

    Shaughnessy, Mary Angela

    This publication addresses issues concerning the application of the law to extended-day Catholic schools. The first chapter provides an overview of extended care. In the second chapter, sources of the law that are applied to extended care programs are described. Canon law affects Catholic schools. Catholic schools are also subject to four types of…

  7. Small and Medium-Sized Enterprises in Concern

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ A common concern The outer environment At present,small and medium-sized enterprises are faced with many serious challenges.Since most of the large-sized enterprises ln China are state-owned ones,small and medium-sized enterprises in this article are referred mainly to those in the private sector.

  8. Comedy Collider presents: No cause for conCERN

    CERN Multimedia

    Traczyk, Piotr

    2014-01-01

    Comedy Collider presents: No cause for conCERN was the highly anticipated follow up to LHComedy: CERN After Dark, starring an entirely new ensemble of comedy talent. Time: 13th June 2014, 19:30 for 20:00 Location: Globe of Science and Innovation, CERN, Geneva, Switzerland

  9. Connecting Cities with Macroeconomic Concerns : The Missing Link

    OpenAIRE

    Freire, Mila; Polèse, Mario; Echeverria, Pamela

    2003-01-01

    Urban growth is, in all parts of the world, inevitable and welcomed. Despite concerns that local governments will not be able to address those issues associated with increased urban population, the number of people living in urban centers will sur-pass those of the rural population by 2030. Since productivity levels are consistently higher in urban areas than in rural settings, this would ...

  10. Metal Detectors in the Public Schools: Fourth Amendment Concerns.

    Science.gov (United States)

    Ferraraccio, Michael

    1999-01-01

    Asks whether proponents' justifications for using metal detectors to counteract school violence are compelling enough to override students' privacy interests. Concludes that there are serious constitutional concerns raised by using metal detectors. The rationale for upholding school searches in other contexts does not apply to metal-detector…

  11. Childhood inflammatory bowel disease: Parental concerns and expectations

    Institute of Scientific and Technical Information of China (English)

    AS Day; KE Whitten; TD Bohane

    2005-01-01

    AIM: To document the concerns and expectations of parents of children with inflammatory bowel disease (IBD)within the context of a multidisciplinary IBD clinic, and to highlight the importance of a holistic approach to the care of these children.METHODS: The parents of 60 children with IBD were surveyed by mailed questionnaire. Parents were asked to provide details of their concerns regarding their child's condition and to express their expectations of medical care. In addition, enquiry was made in respect to the respondents' learning about IBD.RESULTS: Forty-six questionnaires (77%) returned. Fiftytwo percent of the patients were male. Patients were aged a mean of 10.9 (±4.1) years and diagnosed at an average age of 2.1 (±1.8) years previously. The most common concerns expressed by the parents related to the side- effects of medications and the future prospects for their child. Overall, parents were satisfied with aspects of care within the IBD clinic but many suggested additional personnel such as counselors or educators should be available. Parents also reported the need for continuing education and easy access to up-to-date information.CONCLUSION: Parents of children and adolescents with IBD have many common concerns regarding their child's condition. On-going attention to holistic care, including psychosocial and educational elements for patients and families, is appropriate in the context of the chronic and unpredictable nature of IBD.

  12. 40 CFR 35.940-5 - Disputes concerning allowable costs.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Disputes concerning allowable costs. 35.940-5 Section 35.940-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER... relating to cost allowability or allocation at its earliest opportunity (if possible, before execution...

  13. Dust Storms: Why Are Dust Storms a Concern?

    Science.gov (United States)

    ... in Environmental Health, Chemistry, and Toxicology More Resources Dust Storms en español Why are dust storms a concern? A dust storm is a moving ... on Human Health (US Geological Survey) Chemicals in Dust Storms Are these chemicals in MY community? Particulate Matter ...

  14. Big Opportunities and Big Concerns of Big Data in Education

    Science.gov (United States)

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  15. Knowledge, Attitude and Behavior of the Urban Poor Concerning Solid Waste Management: A Case Study

    OpenAIRE

    M.d. Wahid Murad; Chamhuri Siwar

    2007-01-01

    This study has developed three Logistic Regression Models to determine and analyze the factors that could affect knowledge, attitude and behavior of the urban poor concerning solid waste management. To pursue the objective, the study has collected primary data from the level of living conditions of the poor residing in the squatters and low-cost flats of Kuala Lumpur city, Malaysia. The empirical results of the study are exciting as they provide evidence to the effect that knowledge, attitude...

  16. Health Sector Evolution Plan in Iran; Equity and Sustainability Concerns.

    Science.gov (United States)

    Moradi-Lakeh, Maziar; Vosoogh-Moghaddam, Abbas

    2015-10-01

    In 2014, a series of reforms, called as the Health Sector Evolution Plan (HSEP), was launched in the health system of Iran in a stepwise process. HSEP was mainly based on the fifth 5-year health development national strategies (2011-2016). It included different interventions to: increase population coverage of basic health insurance, increase quality of care in the Ministry of Health and Medical Education (MoHME) affiliated hospitals, reduce out-of-pocket (OOP) payments for inpatient services, increase quality of primary healthcare, launch updated relative value units (RVUs) of clinical services, and update tariffs to more realistic values. The reforms resulted in extensive social reaction and different professional feedback. The official monitoring program shows general public satisfaction. However, there are some concerns for sustainability of the programs and equity of financing. Securing financial sources and fairness of the financial contribution to the new programs are the main concerns of policy-makers. Healthcare providers' concerns (as powerful and influential stakeholders) potentially threat the sustainability and efficiency of HSEP. Previous experiences on extending health insurance coverage show that they can lead to a regressive healthcare financing and threat financial equity. To secure financial sources and to increase fairness, the contributions of people to new interventions should be progressive by their income and wealth. A specific progressive tax would be the best source, however, since it is not immediately feasible, a stepwise increase in the progressivity of financing must be followed. Technical concerns of healthcare providers (such as nonplausible RVUs for specific procedures or nonefficient insurance-provider processes) should be addressed through proper revision(s) while nontechnical concerns (which are derived from conflicting interests) must be responded through clarification and providing transparent information. The requirements of

  17. Health Sector Evolution Plan in Iran; Equity and Sustainability Concerns

    Directory of Open Access Journals (Sweden)

    Maziar Moradi-Lakeh

    2015-10-01

    Full Text Available In 2014, a series of reforms, called as the Health Sector Evolution Plan (HSEP, was launched in the health system of Iran in a stepwise process. HSEP was mainly based on the fifth 5-year health development national strategies (2011-2016. It included different interventions to: increase population coverage of basic health insurance, increase quality of care in the Ministry of Health and Medical Education (MoHME affiliated hospitals, reduce out-of-pocket (OOP payments for inpatient services, increase quality of primary healthcare, launch updated relative value units (RVUs of clinical services, and update tariffs to more realistic values. The reforms resulted in extensive social reaction and different professional feedback. The official monitoring program shows general public satisfaction. However, there are some concerns for sustainability of the programs and equity of financing. Securing financial sources and fairness of the financial contribution to the new programs are the main concerns of policy-makers. Healthcare providers’ concerns (as powerful and influential stakeholders potentially threat the sustainability and efficiency of HSEP. Previous experiences on extending health insurance coverage show that they can lead to a regressive healthcare financing and threat financial equity. To secure financial sources and to increase fairness, the contributions of people to new interventions should be progressive by their income and wealth. A specific progressive tax would be the best source, however, since it is not immediately feasible, a stepwise increase in the progressivity of financing must be followed. Technical concerns of healthcare providers (such as nonplausible RVUs for specific procedures or nonefficient insurance-provider processes should be addressed through proper revision(s while nontechnical concerns (which are derived from conflicting interests must be responded through clarification and providing transparent information. The

  18. Perfectionism and changes in athlete burnout over three months: Interactive effects of personal standards and evaluative concerns perfectionism

    OpenAIRE

    Madigan, Daniel J; Stoeber, Joachim; Passfield, Louis

    2016-01-01

    Objectives: A recent longitudinal study with junior athletes (Madigan, Stoeber, & Passfield, 2015) found perfectionism to predict changes in athlete burnout: evaluative concerns perfectionism predicted increases in burnout over a 3-month period, whereas personal standards perfectionism predicted decreases. The present study sought to expand on these findings by using the framework of the 2 × 2 model of perfectionism (Gaudreau & Thompson, 2010) to examine whether evaluative concerns perfection...

  19. Needs and concerns of male combat Veterans with mild traumatic brain injury

    OpenAIRE

    Virginia S. Daggett, PhD, RN; Tamilyn Bakas, PhD, RN, FAHA, FAAN; Janice Buelow, PhD, RN, FAAN; Barbara Habermann, PhD, RN; Laura L. Murray, PhD, CCC-SLP

    2013-01-01

    Traumatic brain injury (TBI) has emerged as a major cause of morbidity among U.S. servicemembers who have served in Iraq and Afghanistan. Even mild TBI (mTBI) can result in cognitive impairments that can affect the community reintegration of Veterans postdeployment. The purpose of this study was to explore the needs and concerns of combat Veterans with mTBI to provide support for an mTBI-specific conceptual model (Conceptual Model in the Context of mTBI) derived from Ferrans et al.’s health-r...

  20. Temperament types: midlife death concerns, demographics, and intensity of crisis.

    Science.gov (United States)

    Waskel, S A

    1995-03-01

    Individuals (N = 331) between the ages 35 and 55 completed a death concern scale and a temperament type sorter and provided information relative to the intensity of and their ability to identify a midlife crisis event. Participants were classified within temperament types by gender, education level, crisis intensity, and ability to identify the crisis event. Five temperament types (ESTJ [extrovert, sensing, thinking, judging], ESFJ [extrovert, sensing, feeling, judging], ISFJ [introvert, sensing, feeling, judging], ISTJ [introvert, sensing, thinking, judging], and ENFP [extrovert, intuitive, feeling, perceiving]) significantly correlated with thinking about and anxiety about death. Gender and education level, as well as crisis intensity, also correlated significantly with death concerns. Temperament type characteristics that may have relevancy to the findings are discussed. PMID:7760296

  1. Energy decisions reframed as justice and ethical concerns

    Science.gov (United States)

    Sovacool, Benjamin K.; Heffron, Raphael J.; McCauley, Darren; Goldthau, Andreas

    2016-05-01

    All too often, energy policy and technology discussions are limited to the domains of engineering and economics. Many energy consumers, and even analysts and policymakers, confront and frame energy and climate risks in a moral vacuum, rarely incorporating broader social justice concerns. Here, to remedy this gap, we investigate how concepts from justice and ethics can inform energy decision-making by reframing five energy problems — nuclear waste, involuntary resettlement, energy pollution, energy poverty and climate change — as pressing justice concerns. We conclude by proposing an energy justice framework centred on availability, affordability, due process, transparency and accountability, sustainability, equity and responsibility, which highlights the futurity, fairness and equity dimensions of energy production and use.

  2. Environmental health concerns of the Persian Gulf War.

    Science.gov (United States)

    Young, R C; Rachal, R E; Huguley, J W

    1992-05-01

    Environmental health concerns in the Persian Gulf are peculiar to the geography of the region. Prevention of heat and solar injury deserves primary consideration, but cold injury also may occur in the desert. Immunizations are recommended against a number of diseases, while malarial chemoprophylaxis is necessary in Iraq and Kuwait. In addition to malaria, other parasitic diseases deserve consideration. Diarrheal diseases, diseases from the desert dust, and products of infected desert animals are of concern. Additional natural hazards are venomous bites from scorpions and desert snakes. Finally, threats of enemy action necessitated protection from nuclear biological and chemical weapons and LASER eye/skin injury. Unexploded ordinance will constitute a continuing hazard into the future. PMID:1495114

  3. A framework for understanding the concerns of ecological designers

    International Nuclear Information System (INIS)

    This paper creates a theoretical framework of analysis for understanding the concerns and methods of ecological designers. Various definitions of ecological design are reviewed to show its basis in natural ecological systems, either as analog or as context, and its purpose as creating sustainability. Ecological design methods are categorized as conceptual, factual, or integrative. The characteristics and definitions of these methods are explained and several practitioners and theorists classified. Lyle's concept of ecosystematic order is used to show the basis of methods in either a building architecture or a landscape architecture perspective. A matrix is generated and applied to a representative of each category, showing the concerns of each in terms of the integration of human and natural ecosystem structure, function, and location

  4. Patients' concern about their medicine after a generic switch

    DEFF Research Database (Denmark)

    Østergaard Rathe, Jette; Søndergaard, Jens; Jarbøl, Dorte E; Hallas, Jesper; Andersen, Morten

    2014-01-01

    treatment. We also included general beliefs about medicine (BMQ), views on generic medicine and confidence in the health-care system. The information about the patients' generic switch was obtained from a prescription database and not provided by the patients. Data were analysed using linear regression......PURPOSE: This study aims to investigate the possible association between patients' concerns about their medicine and generic switch. METHODS: Cross-sectional survey was carried out comprising responses from 2217 randomly selected persons aged 20 years or older and living in the Region of Southern...... Denmark, who had redeemed generically substitutable drugs in September 2008. For each patient, we focused on the purchase of one generically substitutable drug (index drug). We applied the specific concerns subscale from the Beliefs about Medicine Questionnaire (BMQ) to analyse lack of confidence in...

  5. Nanoparticles and the blood coagulation system. Part II: safety concerns

    OpenAIRE

    Ilinskaya, Anna N; Dobrovolskaia, Marina A.

    2013-01-01

    Nanoparticle interactions with the blood coagulation system can be beneficial or adverse depending on the intended use of a nanomaterial. Nanoparticles can be engineered to be procoagulant or to carry coagulation-initiating factors to treat certain disorders. Likewise, they can be designed to be anticoagulant or to carry anticoagulant drugs to intervene in other pathological conditions in which coagulation is a concern. An overview of the coagulation system was given and a discussion of a des...

  6. Food production, distribution and culture: public views, interests and concerns

    OpenAIRE

    Kupiec-Teahan, Beata; Leat, Philip M.K.; Revoredo-Giha, Cesar

    2009-01-01

    A basic right of both a consumer and a citizen is the right to be heard, and their voiced concerns have to be taken into account when developing policies and obtaining trust for government actions. Therefore this study focuses on consumers’ interests, opinions and expectations which are identified and categorised according to subject area, degree of involvement and political agenda of a consumer. The paper draws on the responses of individual members of the public in the National Food Policy ...

  7. Legislation concerning alcohol and drug intake in the workplace

    OpenAIRE

    Eliza Goszczyńska

    2013-01-01

    It is likely that the complex law concerning alcohol and drugs in the workplace is one of the reasons for unwillingness to resolve the problem of intake of such psychoactive substances by employees. Therefore, the author made an attempt to depict Polish legislation in this field based on the review of legal acts and regulations, as well as on their extensive judiciary interpretation. Such an information can be used by employers in developing their workplace policy of diminishing the intake of...

  8. Questions Concerning Matrix Algebras and Invariance of Spectrum

    Indian Academy of Sciences (India)

    Bruce A Barnes

    2003-02-01

    Let and be unital Banach algebras with a subalgebra of . Denote the algebra of all × matrices with entries from by $M_n(A)$. In this paper we prove some results concerning the open question: If is inverse closed in , then is $M_n(A)$ inverse closed in $M_n(B)$? We also study related questions in the setting where is a symmetric Banach ∗-algebra.

  9. Perinatal Antidepressant Use: Understanding Women’s Preferences and Concerns

    OpenAIRE

    Battle, Cynthia L.; Salisbury, Amy L.; SCHOFIELD, CASEY A.; ORTIZ-HERNANDEZ, SAMIA

    2013-01-01

    Perinatal depression is prevalent and linked with a host of adverse consequences for women and newborns. Rates of engagement in depression treatment are, however, strikingly low among pregnant and postpartum women, with the majority of affected women receiving no mental health treatment. Research indicates that perinatal women are extremely reluctant to take antidepressant medications, yet the nature of women’s concerns and treatment decisionmaking patterns have not been well documented. Deve...

  10. A multi-cultural investigation into consumer environmental concern

    Directory of Open Access Journals (Sweden)

    G. G. Rousseau

    2001-01-01

    Full Text Available The main objectives of this study were to investigate the relationship between consumer attitudes and perceptions towards environmental concern and to measure levels of environmental concern amongst multicultural groups. The study was based on past research in the field and uses a modified version of a questionnaire developed by various authors. A non-probability convenience sample (N=340 was drawn from English, Afrikaans and Xhosa-speaking respondents in the Eastern Cape. Fieldwork was carried out by students of Industrial Psychology at the University of Port Elizabeth. Results suggest that cultural influences deduced from home language and suburb are an important factor in determining environmental concern. Results further suggest that environmental concern influences buying preferences and attitudes toward environmental conservation and behaviour. These results have important implications for market segmentation, town planning and development. Opsomming Die hoof doelstelling van hierdie studie was om die verband tussen verbruikershoudings en waarnemings ten opsigte van omgewingsbesorgdheid te ondersoek en vlakke van omgewingsbesorgdheid by multikulturele groepe te meet. Die studie is gegrond op vorige navorsing in die veld en gebruik 'n aangepaste weergawe van 'n vraelys ontwikkel deur verskeie outeurs. n Nie-ewekansige gerieflikheidsteekproef (N=340 is getrek uit Engels, Afrikaans en Xhosa-sprekende respondente in die Oos-Kaap. Veldwerk is uitgevoer deur Bedryfsielkunde studente van die Universiteit van Port Elizabeth. Bevindinge suggereer dat kulturele invloede, afgelei van huistaal en voorstad, belangrike faktore is in die bepaling van omgewingsbesorgdheid. Bevindinge suggereer verder dat omgewingsbesorgdheid, koopvoorkeure en houdings ten opsigte van omgewingsbewaring en optrede beihvloed. Hierdie resultate het belangrike implikasies vir marksegmentasie, stadsbeplanning en ontwikkeling.

  11. ACCESS METHODS CONCERNING THE CONSTITUTIONAL CONTROL OF THE CONSTITUTIONAL COURT

    OpenAIRE

    Gabriela NEMTOI

    2009-01-01

    The study concerning the laws’ constitutionality represents the reason of constitutional warranty on judicial standards, which governs a democratic state. The supremacy of constitution is only a principle, which has to be doubled by establishing a mechanism creating consistency to it. In order to assure the supremacy of constitution, the doctrine and constitutional practice have created efficient judicial institutions, the control of laws’ constitutionality by the competency of Constitutional...

  12. Subjectivity and consumption: concerns for radical adult education

    OpenAIRE

    Ryan, Anne B.

    2004-01-01

    This chapter posits that the linked issues of subjectivity and consumption are essential concerns for contemporary radical adult education. Radical adult education has 'a dialectical and organic relationship with social movements' (Crowther, Martin and Shaw, 2000: 172). It is socially and politically committed, in the sense that it seeks to promote equality and social justice. The term subjectivity is developed throughout the chapter, but, briefly, it refers to the subjective sense of the se...

  13. Concern over Zika virus outbreak: another alarming global threat

    OpenAIRE

    Hafiz, Muhammad Yusuf; S U Mahmood, Syed Uzair; Shoaib, Maria; Yusuf, Farah Hafiz

    2016-01-01

    Muhammad Yusuf Hafiz,1 Syed Uzair Mahmood,2 Maria Shoaib,1 Farah Hafiz Yusuf1 1Dow Medical College, Dow University of Health Sciences, 2Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan Abstract: Zika virus, as highlighted by the World Health Organization in February 2016, has emerged as a public health emergency of international concern. Zika virus is enveloped and icosahedral, and has a nonsegmented, single-stranded, positive-sense RNA genome. It belongs to Flaviviri...

  14. The perception of inclusive education professionals concerning Occupational Therapy

    OpenAIRE

    Ana Paula Morais Braga; Andrezza Fernandes de Andrade

    2009-01-01

    Objective: To investigate the level of knowledge of two principals and four teachers of public schools from a city in Ceará, concerning the Occupational Therapy in the process of school inclusion, showing the level of formation of these professionals regarding inclusive education. Method: A field research, with a qualitative interventionist approach, using the comparative method. Interviews were carried out as well as interventions by means of lectures and group dynamics dealing with subjects...

  15. Second-best urban tolling with distributive concerns

    OpenAIRE

    Diaz, Andrea; Proost, Stef

    2014-01-01

    This paper analyzes the optimal urban congestion toll in a second-best setting where only one road in a network can be tolled. Both heterogeneity in labor productivity and income distribution concerns are considered. The optimal toll balances two types of considerations. The first consideration is the correction of the congestion externality on the tolled road given the distortion on the non-tolled roads, while the second is the equity consideration that takes into account which income group ...

  16. Consolation as possible expression of sympathetic concern among chimpanzees

    OpenAIRE

    Romero, Teresa; Castellanos, Miguel A.; de Waal, Frans B. M.

    2010-01-01

    Chimpanzees are known to spontaneously provide contact comfort to recent victims of aggression, a behavior known as consolation. Similar behavior in human children is attributed to empathic or sympathetic concern. In line with this empathy hypothesis, chimpanzee consolation has been shown to reduce the recipient's state of arousal, hence to likely alleviate distress. Other predictions from the empathy hypothesis have rarely been tested, however, owing to small sample sizes in previous studies...

  17. Seeking Opinions Concerning... : - the Swedish Olympic Committee and its Trademarks

    OpenAIRE

    Arklöf, Rebecca

    2007-01-01

    Background: In the XX Winter Olympics 2006 in Torino the Swedish Olympic Team succeeded by winning 14 medals. The best result that Sweden has ever made during a Winter Olympics. The happiness was shortly after mixed with disputes between the Swedish Olympic Committee and Swedish companies. There were companies who wrongly had used the trademark ‘OS’ in their marketing campaigns. The disputes happened because the use of the protected trademarks concerning the Olympic Games are reserved only to...

  18. Selected legal and regulatory concerns affecting domestic energy transportation systems

    International Nuclear Information System (INIS)

    This report provides assessments of eight legal and regulatory concerns that may affect energy material transportation in the US during the rest of the century: state authority to regulate nuclear materials transport, divestiture of petroleum pipelines from major integrated oil companies, problems affecting the natural gas transportation system, capabilities of energy transportation systems during emergencies, Federal coal pipeline legislation, ability of Federal agencies to anticipate railroad difficulties, abandonment of uneconomic railroad lines, and impact of the Panama Canal treaty upon US energy transportation

  19. On Addressing Efficiency Concerns in Privacy Preserving Data Mining

    OpenAIRE

    Agrawal, Shipra; Krishnan, Vijay; Haritsa, Jayant

    2003-01-01

    Data mining services require accurate input data for their results to be meaningful, but privacy concerns may influence users to provide spurious information. To encourage users to provide correct inputs, we recently proposed a data distortion scheme for association rule mining that simultaneously provides both privacy to the user and accuracy in the mining results. However, mining the distorted database can be orders of magnitude more time-consuming as compared to mining the original databas...

  20. Oral-dental concerns of the pediatric oncology patient

    International Nuclear Information System (INIS)

    One of the main concerns of all disciplines in health care today is maintaining the patient's quality of life and comfort during cancer therapy. Oral complications resulting from radiation or chemotherapy can be expected in a large percentage of patients. Conducting a dental evaluation and performing treatment before therapy can help prevent or lessen potential complications. With preventive care and fewer infections, the patient will be able to communicate with friends and family, and optimum care and comfort can be provided