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Sample records for binding competitive

  1. Paracetamol and cytarabine binding competition in high affinity binding sites of transporting protein

    Science.gov (United States)

    Sułkowska, A.; Bojko, B.; Równicka, J.; Sułkowski, W. W.

    2006-07-01

    Paracetamol (acetaminophen, AA) the most popular analgesic drug is commonly used in the treatment of pain in patients suffering from cancer. In our studies, we evaluated the competition in binding with serum albumin between paracetamol (AA) and cytarabine, antyleukemic drug (araC). The presence of one drug can alter the binding affinity of albumin towards the second one. Such interaction can result in changing of the free fraction of the one of these drugs in blood. Two spectroscopic methods were used to determine high affinity binding sites and the competition of the drugs. Basing on the change of the serum albumin fluorescence in the presence of either of the drugs the quenching ( KQ) constants for the araC-BSA and AA-BSA systems were calculated. Analysis of UV difference spectra allowed us to describe the changes in drug-protein complexes (araC-albumin and AA-albumin) induced by the presence of the second drug (AA and araC, respectively). The mechanism of competition between araC and AA has been proposed.

  2. Competitive binding of antagonistic peptides fine-tunes stomatal patterning.

    Science.gov (United States)

    Lee, Jin Suk; Hnilova, Marketa; Maes, Michal; Lin, Ya-Chen Lisa; Putarjunan, Aarthi; Han, Soon-Ki; Avila, Julian; Torii, Keiko U

    2015-06-25

    During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalling peptides orchestrate pattern formation at a molecular level remains unclear. Here we report in Arabidopsis that Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)-ER module. Both EPF2 and Stomagen directly bind to ER and its co-receptor TOO MANY MOUTHS. Stomagen peptide competitively replaced EPF2 binding to ER. Furthermore, application of EPF2, but not Stomagen, elicited rapid phosphorylation of downstream signalling components in vivo. Our findings demonstrate how a plant receptor agonist and antagonist define inhibitory and inductive cues to fine-tune tissue patterning on the plant epidermis. PMID:26083750

  3. Competitive protein binding analysis for thyroxine using Sephadex column (Tetralute)

    International Nuclear Information System (INIS)

    The method of competitive protein binding analysis of thyroxine (T4) using Tetralute kit was evaluated. The net retention was decreased when the procedure of competition and separation was performed at a higher temperature but the final T4-I values were constant when the standard and test sera were treated identically. Coefficient of variation (C.V.) was 4% (within-assay) and 6% (between-assay) respectively. However, the T4-I values of pooled serum for quality control were slightly lower in earlier experiments in which correction factors (1.03--1.62 in 18 out of 21 assays) were necessary. T4-I values were determined by the Tetralute in 155 cases. They were as follows: 4.9+-0.8 μg/dl (euthyroid subjects), 6.4+-1.2 μg/dl (cord serum), 7.1+-1.1 μg/dl (pregnant women). 9.0+-3.6 μg/dl (trophoblastic disease), 13.3+-4.8 μg/dl (Graves' disease), 6.3+-1.6 μg/dl (Plummer's disease), 4-I values determined by Tetralute and Res-O-Mat T4 (r=0.96). Following oral administration of Telepaque the serum protein-bound iodine was markedly elevated, while the T4-I determined by Tetralute did not change. In vitro addition of diphenylhydantoin (500 μg/ml), salicylate (4 mg/ml) and phenobarbital (1 mg/ml) had no or little effect on T4 determination by Tetralute. A high concentration of benzbromarone (0.1 mg/ml) caused a higher value of T4-I determined by Tetralute when added to a TBG solution but there was only a slight increase when it was added to serum. (auth.)

  4. Standardization for cortisol determination in human blood by competitive protein-binding

    International Nuclear Information System (INIS)

    Standardization for determination of cortisol from human plasma (17-hydroxycorticosteroids) using competitive protein-binding method is presented. Activated carbon coated with dextrans is used for separation of the hormone-protein complexe and hormone labelled free

  5. Tropomyosin-binding properties modulate competition between tropomodulin isoforms.

    Science.gov (United States)

    Colpan, Mert; Moroz, Natalia A; Gray, Kevin T; Cooper, Dillon A; Diaz, Christian A; Kostyukova, Alla S

    2016-06-15

    The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner. Tmod1, Tmod2 and Tmod3 are associated with the cytoskeleton of non-muscle cells and their expression has distinct consequences on cell morphology. To understand the molecular basis of differences in the function and localization of Tmod isoforms in a cell, we compared the actin filament-binding abilities of Tmod1, Tmod2 and Tmod3 in the presence of Tpm3.1, a non-muscle TM isoform. Tmod3 displayed preferential binding to actin filaments when competing with other isoforms. Mutating the second or both TM-binding sites of Tmod3 destroyed its preferential binding. Our findings clarify how Tmod1, Tmod2 and Tmod3 compete for binding actin filaments. Different binding mechanisms and strengths of Tmod isoforms for Tpm3.1 contribute to their divergent functional capabilities. PMID:27091317

  6. Chemokine cooperativity is caused by competitive glycosaminoglycan binding

    NARCIS (Netherlands)

    Verkaar, F.; Offenbeek, J. van; Lee, M. van der; Lith, L.H. van; Watts, A.O.; Rops, A.L.; Aguilar, D.C.; Ziarek, J.J.; Vlag, J. van der; Handel, T.M.; Volkman, B.F.; Proudfoot, A.E.; Vischer, H.F.; Zaman, G.J.; Smit, M.J.

    2014-01-01

    Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines t

  7. A sensitive competitive binding assay for exogenous and endogenous heparins

    International Nuclear Information System (INIS)

    A new type of assay for heparins has been devised, in which the test material competes with 125I-labelled heparin for binding to protamine-Sepharose. The assay is very sensitive and will measure heparin concentrations down to 10 ng ml-1. It responds to both the degree of sulphation and the molecular weight of acidic polysaccharides, but is independent of their biological activities. It can be used to quantitate heparins in biological fluids after pretreatment of the samples with protease. In this way endogenous heparins were measured in normal human serum, plasma and urine. The assay is extremely versatile and has great potential for the investigation of endogenous and exogenous heparins

  8. High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.

    Science.gov (United States)

    Craviso, G L; Musacchio, J M

    1983-05-01

    Binding of dextromethorphan (DM) to guinea pig brain is stereoselective, since levomethorphan is 20 times weaker than DM in competing for DM sites. In general, opiate agonists and antagonists as well as their corresponding dextrorotatory isomers are weak competitors for tritiated dextromethorphan ([3H]DM) binding sites and display IC50 values in the micromolar range. In contrast, several non-narcotic, centrally acting antitussives are inhibitory in the nanomolar range (IC50 values for caramiphen, carbetapentane, dimethoxanate, and pipazethate are 25 nM, 9 nM, 41 nM, and 190 nM, respectively). Other antitussives, such as levopropoxyphene, chlophedianol, and fominoben, have poor affinity for DM sites whereas the antitussive noscapine enhances DM binding by increasing the affinity of DM for its central binding sites. Additional competition studies indicate that there is no correlation of DM binding with any of the known or putative neurotransmitters in the central nervous system. DM binding is also not related to tricyclic antidepressant binding sites or biogenic amine uptake sites. However, certain phenothiazine neuroleptics and typical and atypical antidepressants inhibit binding with IC50 values in the nanomolar range. Moreover, the anticonvulsant drug diphenylhydantoin enhances DM binding in a manner similar to that of noscapine. Preliminary experiments utilizing acid extracts of brain have not demonstrated the presence of an endogenous ligand for DM sites. The binding characteristics of DM sites studied in rat and mouse brain indicate that the relative potencies of several antitussives to inhibit specific DM binding vary according to species. High-affinity, saturable, and stereoselective [3H]DM binding sites are present in liver homogenates, but several differences have been found for these peripheral binding sites and those described for brain. Although the nature of central DM binding sites is not known, the potent interaction of several classes of centrally

  9. Competitive inhibition of [3H]dexamethasone binding to mammary glucocorticoid receptor by leupeptin

    International Nuclear Information System (INIS)

    The inhibitory effect of leupeptin on [3H]dexamethasone binding to the glucocorticoid receptor from lactating goat mammary cytosol has been studied. Leupeptin (10 mM) caused a significant (about 35%) inhibition of [3H]dexamethasone binding to glucocorticoid receptor. Binding inhibition is further increased following filtration of unlabeled cytosolic receptor through a Bio-Gel A 0.5-m column. Binding inhibition was partially reversed by monothioglycerol at 10 mM concentration. A double reciprocal plot revealed that leupeptin appears to be a competitive inhibitor of [3H]dexamethasone binding to the glucocorticoid receptor. Low salt sucrose density gradient centrifugation revealed that the leupeptin-treated sample formed a slightly larger (approximately 9 S) receptor complex (leupeptin-free complex sediments at 8 S)

  10. Determination of thyroxine concentration in serum by competitive protein binding assay

    International Nuclear Information System (INIS)

    This paper summarized the kits in commercial level used for the determination of thyroxine concentration in serum by competitive protein binding assay, and described the recent tendency. Using the kits in commercial level such as Tetrasorb, Res-O-Mat T4, Thyopac-4 and Tetralute, extraction of thyroxine, culture of 125I-thyroxine of thyroxine-binding-globulin, separation of free 125I-thyroxine from thyroxine-binding-globulin binding 125I-thyroxine, and calculation of thyroxine concentration were explained, and strong or weak points of these kits were examined. Although normal value showed a little difference in the four kits, they reflected well the thyroid function and would be able to be clinically applied. In addition, Res-O-Mat Effective Thyroxine Ratio Test was recently improved to measure free thyroxine index and thyroxine concentration at the same time, and the effectiveness of the test was also explained. (Kanao, N.)

  11. Phosphatidylinositol 4,5-bisphosphate competitively inhibits phorbol ester binding to protein kinase C

    International Nuclear Information System (INIS)

    Calcium phospholipid dependent protein kinase C (PKC) is activated by diacylglycerol (DG) and by phorbol esters and is recognized to be the phorbol ester receptor of cells; DG displaces phorbol ester competitively from PKC. A phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP2), can also activate PKC in the presence of phosphatidylserine (PS) and Ca2+ with a KPIP2 of 0.04 mol %. Preliminary experiments have suggested a common binding site for PIP2 and DG on PKC. Here, the authors investigate the effect of PIP2 on phorbol ester binding to PKC in a mixed micellar assay. In the presence of 20 mol % PS, PIP2 inhibited specific binding of [3H]phorbol 12,13-dibutyrate (PDBu) in a dose-dependent fashion up to 85% at 1 mol %. Inhibition of binding was more pronounced with PIP2 than with DG. Scatchard analysis indicated that the decrease in binding of PDBu in the presence of PIP2 is the result of an altered affinity for the phorbol ester rather than of a change in maximal binding. The plot of apparent dissociation constants (Kd') against PIP2 concentration was linear over a range of 0.01-1 mol % with a Ki of 0.043 mol % and confirmed the competitive nature of inhibition between PDBu and PIP2. Competition between PIP2 and phorbol ester could be determined in a liposomal assay system also. These results indicate that PIP2, DG, and phorbol ester all compete for the same activator-receiving region on the regulatory moiety of protein kinase C, and they lend support to the suggestion that PIP2 is a primary activator of the enzyme

  12. Competitive ligand - binding assay for thyroxine binding globulin. Comparison with TBG radioimmunoassay and T3 uptake test

    International Nuclear Information System (INIS)

    A simple and reproducible competitive ligand binding assay has been utilized to measure serum TBG concentration. In euthyroid subjects TBG concentration (mean +- SD, mg/l) was 33.7 +- 4; hyperthyroid 24 -+ 6; T3-thyrotoxicosis 20 +- 7; hypothyroid 37 -+ 7; pregnant 67 -+ 18; post-partum period 59.8 -+ 17; oral contraceptives 45 -+ 7. The correlation of CLBA with RIA measurement of TBG was significant (p3 uptake test (p4: TBG ratio according to serum T4 and TBG concentration provided a reliable index in the assessment of thyroid function

  13. Eukaryotic initiation factor 4B and the poly(A)-binding protein bind eIF4G competitively.

    Science.gov (United States)

    Cheng, Shijun; Gallie, Daniel R

    2013-01-01

    The eukaryotic translation initiation factor (eIF) 4G functions as a scaffold protein that assembles components of the translation initiation complex required to recruit the 40S ribosomal subunit to an mRNA. Although many eukaryotes express two highly similar eIF4G isoforms, those in plants are highly divergent in size and sequence from one another and are referred to as eIF4G and eIFiso4G. Although the domain organization of eIFiso4G differs substantially from eIF4G orthologs in other species, the domain organization of plant eIF4G is largely unknown despite the fact that it is more similar in size and sequence to eIF4G of other eukaryotes. In this study, we show that eIF4G differs from eIFiso4G in that it contains two distinct interaction domains for the poly(A) binding protein (PABP) and eIF4B but is similar to eIFiso4G in having two eIF4A interaction domains. PABP and eIF4B bind the same N-terminal region of eIF4G as they do to a region C-proximal to the HEAT-1 domain in the middle domain of eIF4G, resulting in competitive binding between eIF4B and PABP to each site. eIF4G also differs from eIFiso4G in that no competitive binding was observed between PABP and eIF4A or between eIF4B and eIF4A to its HEAT-1-containing region. These results demonstrate that despite substantial differences in size, sequence, and domain organization, PABP and eIF4B bind to eIF4G and eIFiso4G competitively. PMID:26824014

  14. Enhanced Activity of Topical Hydrocortisone by Competitive Binding of Corticosteroid-Binding Globulin.

    Science.gov (United States)

    Bodor, Erik T; Wu, Whei-Mei; Chandran, V Ravi; Bodor, Nicholas

    2016-09-01

    Atopic dermatitis of sensitive areas such as the face, particularly in children, is a difficult disease to treat as the standard therapeutic, topical steroids, is contraindicated for this application in children. Hydrocortisone (HC) can be used in these instances because it has been shown to be safe, but is often ineffective as it is a relatively weak steroid, especially at over-the-counter concentrations. To enhance the local topical activity of HC, the terminal inactive metabolite of prednisolone, Δ(1)-cortienic acid (Δ(1)-CA), is added to HC, as Δ(1)-CA preferentially binds transcortin, liberating more HC to elicit its therapeutic effect. Skin blanching studies, which are used to evaluate the potency of topical steroids, were employed to assess the ability of Δ(1)-CA to enhance the activity of HC. The results demonstrate that Δ(1)-CA, when applied in combination with HC, does indeed potentiate the vasoconstriction effect of topically applied HC, while having no effect alone. Thus, addition of the inert prednisolone metabolite Δ(1)-CA can increase the therapeutic effect of over-the-counter concentrations of HC when applied topically. PMID:27179671

  15. Competition

    NARCIS (Netherlands)

    Boone, J.

    2000-01-01

    Competition has been modelled in the literature in a number of ways.What do these different parametrizations of competition have in common?For instance, it turns out that it is not always the case that a rise in competition reduces price cost margins, industry wide profits or concentration.All param

  16. Competitive binding of viral E2 protein and mammalian core-binding factor to transcriptional control sequences of human papillomavirus type 8 and bovine papillomavirus type 1.

    OpenAIRE

    Schmidt, H. M.; Steger, G; Pfister, H

    1997-01-01

    The promoter P7535 of human papillomavirus type 8 and the promoter P7185 of bovine papillomavirus type 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respectively. Mutations of these E2 binding sites can reduce basal promoter activity. This suggests binding of a transcription-stimulating factor and may indicate that repression by E2 is due to competitive binding of viral and cellular proteins. A computer search revealed putative binding sit...

  17. Competition

    OpenAIRE

    Boone, J.

    2000-01-01

    Competition has been modelled in the literature in a number of ways.What do these different parametrizations of competition have in common?For instance, it turns out that it is not always the case that a rise in competition reduces price cost margins, industry wide profits or concentration.All parametrizations of competition, considered here, have two features in common.First, the reallocation effect: a rise in competition raises the profits of a firm relative to the profits of a less efficie...

  18. Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy: A spectroscopic study

    Science.gov (United States)

    Sułkowska, A.; Maciążek-Jurczyk, M.; Bojko, B.; Równicka, J.; Zubik-Skupień, I.; Temba, E.; Pentak, D.; Sułkowski, W. W.

    2008-06-01

    The binding sites for phenylbutazone and colchicine were identified in tertiary structure of bovine and human serum albumin with the use of spectrofluorescence analysis. It was found that phenylbutazone has two binding sites in both sera albumins (HSA and BSA), while colchicine has one binding site in BSA as well as in HSA. The comparison of the quenching effect of BSA and HSA fluorescence by phenylbutazone and colchicine allows us to identify subdomain IIA in protein as the binding site for these two drugs. In this subdomain tryptophan 214 is located. The participation of tyrosyl and tryptophanyl residues of protein was also estimated in the drug-albumin complex. The comparison of quenching of fluorescence of HSA and BSA excited at 280 nm with that at 295 nm allowed us to state that the participation of tyrosyl residues of albumin in the phenylbutazone-serum albumin interaction is significant. The analysis of quenching of fluorescence of BSA in the binary and ternary systems showed that phenylbutazone does not affect the complex formed between colchicine and BSA. Similarly, colchicine has no effect on the Phe-BSA complex. However marked differences were observed for the complex with HSA. On the basis of Ka and KQ values it was concluded that colchicine may probably cause displacement of phenylbutazone from its complex with serum albumin (SA). Static and dynamic quenching for the binary and ternary systems is also discussed. The competition of phenylbutazone and colchicine in binding to serum albumin should be taken into account in the multi-drug therapy.

  19. Competitive receptor binding radioassay for β-1 and β-2 adrenergic agents

    International Nuclear Information System (INIS)

    A rapid and sensitive competitive receptor bonding assay for β-1 and β-2 adrenergic binding for adrenergic agents has been developed. The steps that are critical for the success of the assay are given in detail so that the assay can be set up in any routine laboratory with relative ease. The rationale behind the use of specific reagents is discussed. The assay requires microgram quantities of test compound, a radiolabeled specific β adrenergic antagonist [3H]dihydroalprenolol (DHA), and turkey erythrocyte β-1 and rat erythrocyte β-2 receptor membranes. Serial dilutions of sample are incubated with appropriate receptor membranes and DHA for 1 hr at room temperature. After equilibrium is attained, the bound radioligand is separated by rapid filtration under vacuum through Whatman GF/B filters. The amount of bound DHA trapped on the filter is inversely proportional to the degree of β-1 and β-2 adrenergic binding of the sample. Separation of bound from free radioligand by filtration permits rapid determination of a large number of samples. This assay quantitates and differentiates β-1 and β-2 adrenergic binding of synthetic adrenergic agents

  20. Competition

    Institute of Scientific and Technical Information of China (English)

    吕思思

    2007-01-01

    <正> The term competition reminds me of asoul-stirring fight between a mother monkeyand a crocodile,The crocodile caught her babywhen the baby was drinking water in a pool,Inthe end,the mother got her baby,but herbaby’s body only,She lost her child forever,just for a mouthful of water.Such is competition,cruel and merciless,But if we see the other side of the coin,we’ll

  1. Competitive counterion complexation allows the true host : guest binding constants from a single titration by ionic receptors.

    Science.gov (United States)

    Pessêgo, Márcia; Basílio, Nuno; Muñiz, M Carmen; García-Río, Luis

    2016-07-01

    Counterion competitive complexation is a background process currently ignored by using ionic hosts. Consequently, guest binding constants are strongly affected by the design of the titration experiments in such a way that the results are dependent on the guest concentration and on the presence of added salts, usually buffers. In the present manuscript we show that these experimental difficulties can be overcome by just considering the counterion competitive complexation. Moreover a single titration allows us to obtain not only the true binding constants but also the stoichiometry of the complex showing the formation of 1 : 1 : 1 (host : guest : counterion) complexes. The detection of high stoichiometry complexes is not restricted to a single titration experiment but also to a displacement assay where both competitive and competitive-cooperative complexation models are taken into consideration. PMID:27278457

  2. Surface structural ion adsorption modeling of competitive binding of oxyanions by metal (hydr)oxides

    Energy Technology Data Exchange (ETDEWEB)

    Hiemstra, T.; Riemsdijk, W.H. van [Wageningen Univ. and Research Centre (Netherlands)

    1999-02-01

    An important challenge in surface complexation models (SCM) is to connect the molecular microscopic reality to macroscopic adsorption phenomena. This study elucidates the primary factor controlling the adsorption process by analyzing the adsorption and competition of PO{sub 4}, AsO{sub 4}, and SeO{sub 3}. The authors show that the structure of the surface-complex acting in the dominant electrostatic field can be ascertained as the primary controlling adsorption factor. The surface species of arsenate are identical with those of phosphate and the adsorption behavior is very similar. On the basis of the selenite adsorption, The authors show that the commonly used 1pK models are incapable to incorporate in the adsorption modeling the correct bidentate binding mechanism found by spectroscopy. The use of the bidentate mechanism leads to a proton-oxyanion ratio and corresponding pH dependence that are too large. The inappropriate intrinsic charge attribution to the primary surface groups and the condensation of the inner sphere surface complex to a point charge are responsible for this behavior of commonly used 2pK models. Both key factors are differently defined in the charge distributed multi-site complexation (CD-MUSIC) model and are based in this model on a surface structural approach. The CD-MUSIC model can successfully describe the macroscopic adsorption phenomena using the surface speciation and binding mechanisms as found by spectroscopy. The model is also able to predict the anion competition well. The charge distribution in the interface is in agreement with the observed structure of surface complexes.

  3. Competition

    CERN Multimedia

    Staff Association

    2016-01-01

      The Staff Association is organising a competition from April 11 to 20. There are several Go Sport gift vouchers with a value of 50 € each to win. Try your luck! To participate, you just have to be a member of the Staff Association and take the online quiz: https://ap-vote.web.cern.ch/content/jeu-concours. The winners will be drawn among the correct answers.

  4. Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.

    Science.gov (United States)

    Kessler, Jan H; Mommaas, Bregje; Mutis, Tuna; Huijbers, Ivo; Vissers, Debby; Benckhuijsen, Willemien E; Schreuder, Geziena M Th; Offringa, Rienk; Goulmy, Els; Melief, Cornelis J M; van der Burg, Sjoerd H; Drijfhout, Jan W

    2003-02-01

    We report the development, validation, and application of competition-based peptide binding assays for 13 prevalent human leukocyte antigen (HLA) class I alleles. The assays are based on peptide binding to HLA molecules on living cells carrying the particular allele. Competition for binding between the test peptide of interest and a fluorescein-labeled HLA class I binding peptide is used as read out. The use of cell membrane-bound HLA class I molecules circumvents the need for laborious biochemical purification of these molecules in soluble form. Previously, we have applied this principle for HLA-A2 and HLA-A3. We now describe the assays for HLA-A1, HLA-A11, HLA-A24, HLA-A68, HLA-B7, HLA-B8, HLA-B14, HLA-B35, HLA-B60, HLA-B61, and HLA-B62. Together with HLA-A2 and HLA-A3, these alleles cover more than 95% of the Caucasian population. Several allele-specific parameters were determined for each assay. Using these assays, we identified novel HLA class I high-affinity binding peptides from HIVpol, p53, PRAME, and minor histocompatibility antigen HA-1. Thus these convenient and accurate peptide-binding assays will be useful for the identification of putative cytotoxic T lymphocyte epitopes presented on a diverse array of HLA class I molecules. PMID:12559627

  5. Effect of dioxane on the binding of competitive inhibitor proflavin and catalytic activity of bovine pancreatic α-chymotrypsin

    Science.gov (United States)

    Sirotkin, V. A.; Mukhametzyanov, T. A.; Karmanova, Yu. V.

    2007-07-01

    The binding of competitive inhibitor proflavin by α-chymotrypsin in water-dioxane mixtures over the entire range of thermodynamic activities of water a w was studied. The data on the degree of binding of proflavin were compared to the results on the catalytic activity of the enzyme preliminary incubated in water-dioxane mixtures. An analysis of the behavior of the concentration dependences of these characteristics demonstrated that, at low a w values, the behavior of the interprotein contacts in the enzyme formed during its drying largely governs its functional properties, while at high a w values, they are determined by the interaction of the enzyme with the organic solvent. Interplay of these two factors is responsible for the observed complex shape of the isotherm of binding of proflavin, with the maximum degree of binding being attained at moderate a w values.

  6. Cross-competition of somatostatin with vasoactive intestinal peptide for binding to the somatostatin receptor subtype 3

    International Nuclear Information System (INIS)

    Full text: Recent studies suggest that a variety of tumor cells express both receptors (R) for somatostatin-14 (SST) and vasoactive intestinal peptide (VIP). We have observed cross-competition between SST and VIP for binding to various tumor cells. The present study was conducted to identify the common binding site of SST and VIP. For this purpose, COS-7 cells were transfected with the hSSTR1 through 5 as well as with the hVIPR1 and hVIPR2. 125I-SST, 123I-Tyr3-OCT and 123I-VIP were used as radioligands. A direct binding studies and northern blot analysis were performed. High affinity binding of 125I-SST to hSSTR1, hSSTR2, hSSTR3, hSSTR4 and hSSTR5 was observed. 123I-Tyr3-OCT bound to hSSTR2 and hSSTR5 with high affinity and to hSSTR3 with moderate affinity. 125I-SST as well as 123I-Tyr3-OCT did not bind to hVIPR1 or hVIPR2. In contrast, high affinity binding of 123I-VIP to hVIPR1, hVIPR2 and to hSSTR3, but not to other hSSTR, was detectable. Binding of 125I-SST to hSSTR3 was displaced by unlabeled SST, VIP as well as by Tyr3-OCT. Binding of 123I-VIP to hSSTR3 was inhibited by unlabeled VIP, SST and Tyr3-OCT. Our data provide evidence that the hSSTR3 may act as an acceptor for VIP and is the primary site responsible of cross-competition between 125I-SST and 123I-VIP. (author)

  7. Fluorescence analysis of competition of phenylbutazone and methotrexate in binding to serum albumin in combination treatment in rheumatology

    Science.gov (United States)

    Maciążek-Jurczyk, M.; Sułkowska, A.; Bojko, B.; Równicka, J.; Sułkowski, W. W.

    2009-04-01

    Combination of several drugs is often necessary especially during long-them therapy. The competition between drugs can cause a decrease of the amount of a drug bound to albumin. This results in an increase of the free, biological active fraction of the drug. The aim of the presented study was to describe the competition between phenylbutazone (Phe) and methotrexate (MTX), two drugs recommended for the treatment of rheumatology in binding to bovine (BSA) and human (HSA) serum albumin in the high affinity binding site. Fluorescence analysis was used to estimate the effect of drugs on the protein fluorescence and to define the binding and quenching properties of drugs-serum albumin complexes. The effect of the displacement of one drug from the complex of the other with serum albumin has been described on the basis of the comparison of the quenching curves and binding constants for the binary and ternary systems. The conclusion that both Phe and MTX form a binding site in the same subdomain (IIA) points to the necessity of using a monitoring therapy owning to the possible increase of the uncontrolled toxic effects.

  8. Competitive binding of transcription factors drives Mendelian dominance in regulatory genetic pathways

    OpenAIRE

    Porter, Adam H.; Johnson, Norman A.; Tulchinsky, Alexander Y.

    2016-01-01

    We report a new mechanism for allelic dominance in regulatory genetic interactions that we call binding dominance. We investigated a biophysical model of gene regulation, where the fractional occupancy of a transcription factor (TF) on the cis-regulated promoter site it binds to is determined by binding energy (-{\\Delta}G) and TF concentration. Transcription and gene expression proceed when the TF is bound to the promoter. In diploids, individuals may be heterozygous at the cis-site, at the T...

  9. Competition for in vitro [3H]gibberellin A4 binding in cucumber by substituted phthalimides

    International Nuclear Information System (INIS)

    Certain N-substituted phthalimides (NSPs) have gibberellin (GA)-like activity in a number of GA bioassays. The interaction between representative NSPs and a protein fraction from cucumber (Cucumis sativus L.) hypocotyls that has GA-binding characteristics consistent with those expected of GA receptors was studied. Analysis of in vitro equilibrium saturation data indicated the presence of only one class of high affinity [3H]GA4 binding sites (Kd ∼30 nanomolar, n = 0.25 picomole per milligram of protein). In the presence of 6 or 60 micromolar 1-[3-chlorophthalimido]-cyclohexanecarboximide (AC-94,377), the Kd for [3H]GA4 increased, whereas the maximum number of saturable [3H]GA4 binding sites did not change significantly. The dissociation of [3H]GA4 from its binding sites was complex and was best described by a bi-exponential equation. AC-94,377 did not affect the rates of [3H]GA4 dissociation from its binding sites. These results implied that AC-94,377 and [3H]GA4 compete for binding to the same sites. A correlation was observed between the activity of over 20 NSPs in the cucumber hypocotyl bioassay and their in vitro affinity for the GA binding sites. Our observations lend further support to the notion that certain GA binding proteins in cucumber cytosol are GA receptors and also provide a molecular explanation for the GA-like in vivo activity of some NSPs

  10. In vitro binding of plutonium to human transferrin and competition reaction with ferric ions

    International Nuclear Information System (INIS)

    Plutonium was found to bind strongly to human transferrin, however a maximum capacity of absorption was observed. Presaturation with iron of transferrin resulted in a decrease of plutonium binding, but it still remained appreciable. It was largely affected by the pH as well as by the degree of ferric saturation of the transferrin. (authors)

  11. Inhibition of CK2 Activity by TCDD via Binding to ATP-competitive Binding Site of Catalytic Subunit:Insight from Computational Studies

    Institute of Scientific and Technical Information of China (English)

    XU Xian-jin; CANNISTRARO Salvatore; BIZZARRI Anna-rita; ZENG Yi; CHEN Wei-zu; WANG Cun-xin

    2013-01-01

    Alternative mechanisms of toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD),instead of the binding to aryl hydrocarbon receptor(AhR),have been taken into consideration.It has been recently shown that TCDD reduces rapidly the activity of CK2(casein kinase Ⅱ) both in vivo and in vitro.It is found that TCDD has high molecular similarities to the known inhibitors of CK2 catalytic subunit(CK2α).This suggests that TCDD could also be an ATP-competitive inhibitor of CK2α.In this work,docking TCDD to CK2 was carried out based on the two structures of CK2α from maize and human,respectively.The binding free energies of the predicted CK2α-TCDD complexes estimated by the molecular mechanics/Poisson-Boltzmann surface area(MM/PBSA) method are from -85.1 kJ/mol to-114.3 kJ/mol for maize and are from-96.1 kJ/mol to-118.2 kJ/mol for human,which are comparable to those estimated for the known inhibitor and also ATP with CK2α.The energetic analysis also reveals that the van der Waals interaction is the dominant contribution to the binding free energy.These results are also useful for designing new drugs for a target of overexpressing CK2 in cancers.

  12. Automated measurement of serum thyroxine with the ''AIRA II,'' as compared with competitive protein binding and radioimmunoassay

    International Nuclear Information System (INIS)

    Two conventional serum thyroxine assays, run in separate laboratories, one by competitive protein binding and one by radioimmunoassay, were used to evaluate the automated ARIA II (Becton Dickinson Immunodiagnostics) serum thyroxine assay. Competitive protein binding as compared to ARIA II with 111 clinical serum samples gave a slope of 1.04 and a correlation coefficient of 0.94. The radioimmunoassay comparison to ARIA II with 53 clinical serum samples gave a slope of 1.05 and a correlation coefficient of 0.92. The ARIA II inter-assay coefficient of variation for 10 replicates of low, medium, and high thyroxine serum samples was 6.2, 6.0, and 2.9%, respectively, with an inter-assay coefficient of variation among 15 different assays of 15.5, 10.1, and 7.9%. The automated ARIA II, with a 2.2-min cycle per sample, gives results that compare well with those by manual methodology

  13. Machine learning competition in immunology – Prediction of HLA class I binding peptides

    DEFF Research Database (Denmark)

    Zhang, Guang Lan; Ansari, Hifzur Rahman; Bradley, Phil;

    2011-01-01

    ., 2008] and [Larsen et al., 2010]). HTMS involves HLA typing, immunoaffinity chromatography of HLA molecules, HLA extraction, and chromatography combined with tandem mass spectrometry, followed by the application of computational algorithms for peptide characterization (Bassani-Sternberg et al., 2010......). Hundreds of naturally processed HLA class I associated peptides have been identified in individual studies using HTMS in normal (Escobar et al., 2008), cancer ( [Antwi et al., 2009] and [Bassani-Sternberg et al., 2010]), autoimmunity-related (Ben Dror et al., 2010), and infected samples (Wahl et al, 2010...... of peptide binding, therefore, determines the accuracy of the overall method. Computational predictions of peptide binding to HLA, both class I and class II, use a variety of algorithms ranging from binding motifs to advanced machine learning techniques ( [Brusic et al., 2004] and [Lafuente and Reche...

  14. Inclusion complex formation of ionic liquids with 4-sulfonatocalixarenes studied by competitive binding of berberine alkaloid fluorescent probe

    Science.gov (United States)

    Miskolczy, Zsombor; Biczók, László

    2009-07-01

    A clinically important natural isoquinoline alkaloid, berberine, was used as a fluorescent probe to study the encapsulation of 1-alkyl-3-methylimidazolium (C nMIm +) type ionic liquids in 4-sulfonato-substituted calix[4]arene (SCX4) and calix[6]arene (SCX6) at pH 2. Addition of ionic liquids to the aqueous solution of berberine-SCXn inclusion complexes brought about considerable fluorescence intensity diminution due to the extrusion of berberine from the macrocycle into the aqueous phase by the competitive inclusion of C nMIm + cation. The lengthening of the aliphatic side chain of the imidazolium moiety diminished the equilibrium constant of complexation with SCX4, but enhanced the stability of SCX6 complexes. Larger binding strength was found for SCX4.

  15. Competition of dipositive metal ions for Fe (III) binding sites in chelation therapy of Iron Load

    International Nuclear Information System (INIS)

    Iron overload is a condition in which excessive iron deposited in the liver, kidney and spleen of human beings in the patients of beta thalassemia and sickle cell anemia. Instead of its importance iron could be toxic when in excess, it damages the tissues. For the treatment of iron overload, a drug desferrioxamine mesylate has been used. It is linear trihydroxamic acid, a natural siderophore produced by streptomyces which removes the extra iron from body. Salicylhydroxamate type siderphore. In present research salicylhydroxamate was used for the complexation with dipositive metal ions which are available in biological environments such as Mn (II), Co (II), Ni (II) and Cu (II). The aim of our work was to study the competition reactions between Fe (III) and other dipositive ions; to calculate the thermodynamic data of chelation of these metal ions complexes with hydroxamate by computer program and comparison with hydroxamate complexes. (author)

  16. Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

    DEFF Research Database (Denmark)

    Faure, Helene; Gorojankina, Tatiana; Rice, Nadejda;

    2009-01-01

    Calindol antagonist activity but was without effect on NPS2143 inhibitory response. In summary, these data suggest that Calindol is primarily anchored through an H-bond to E816(7.39) in TM7 and highlight important local differences at the level of the CaSR and GPRC6A allosteric binding pockets. We have...... identified the first antagonists of GPRC6A that could represent new tools to analyze GPRC6A functions and serve as chemical leads for the development of more specific modulators....

  17. PUMA promotes Bax translocation by competitive binding to Bcl-Xl during UV-induced apoptosis

    Science.gov (United States)

    Zhang, Yingjie; Xing, Da; Wu, Yinyuan; Liu, Lei

    2008-02-01

    Ultraviolet (UV) irradiation can induce apoptosis through both the membrane death receptor and the intrinsic apoptotic signaling pathways as DNA-damaging agents. PUMA, a BH3-only Bcl-2 family protein, plays an essential role in DNA damage-induced apoptosis. Bax, also a Bcl-2 family member, translocates from the cytosol to the mitochondrial membrane during UV-induced apoptosis. However, the regulation of Bax activation induced by UV irradiation remains poorly understood. In this study, the FRET (fluorescence resonance energy transfer) technique was used to study the interactions of Bax, Bcl-Xl, and PUMA in ASTC-a-1 cells. The results show that Bax translocated from the cytosol to the mitochondrial membrane at about 7 h after UV irradiation, and the translocation can not be blocked completely when overexpressed Bcl-xl. Moreover, The interaction of Bax and Bcl-Xl weakened markedly. In addition, Co-immunoprecipitation shows that PUMA released Bax by directly binding to Bcl-XL after UV irradiation in ASTC-a-1 cells. Taken together, these results indicated that PUMA can promote Bax translocation by binding to Bcl-Xl during UV-induced apoptosis.

  18. Activation of Hsp90/NOS and increased NO generation does not impair mitochondrial respiratory chain by competitive binding at cytochrome C Oxidase in low oxygen concentrations

    OpenAIRE

    Presley, Tennille; Vedam, Kaushik; Liu, Xiaoping; Zweier, Jay L.; Ilangovan, Govindasamy

    2009-01-01

    Nitric oxide (NO) is known to regulate mitochondrial respiration, especially during metabolic stress and disease, by nitrosation of the mitochondrial electron transport chain (ETC) complexes (irreversible) and by a competitive binding at O2 binding site of cytochrome c oxidase (CcO) in complex IV (reversible). In this study, by using bovine aortic endothelial cells, we demonstrate that the inhibitory effect of endogenously generated NO by nitric oxide synthase (NOS) activation, by either NOS ...

  19. Competition of aluminium on iron binding site in the biological system

    International Nuclear Information System (INIS)

    Aluminum toxicity has been recognized in many ways, when exposure to heavy metals is prolonged, renal function is limited or a previously accumulated bone burden is released in stress and illness. Aluminum is generally found in +3 oxidation state, so sometimes it competes for the binding sites of Fe(III) in the biological system. If the concentration of Aluminum exceeds above the normal, it inhibits the absorption of Iron and Iron deficiency leads to diseases such as Parkinson's and Alzheimer. The complex formations of Al(III) and Fe(III) with salicylic hydroxamate were studied potentiometrically at different temperatures and data were subjected to computer programs. The stability constant (log beta) values and thermodynamic stabilities were calculated. It was found that salicylic hydroxamate forms 1:1 complex at pH 3 and 1: 2 complex at pH 4 with Al(III) and Fe(III), respectively. The stability constant (log beta) and thermodynamic stabilities of Al(III) salicylic hydroxamate complexes are close to Fe(III) salicylic hydroxamate complexes. (author)

  20. Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa.

    Science.gov (United States)

    Joachim, Ines; Rikker, Sebastian; Hauck, Dirk; Ponader, Daniela; Boden, Sophia; Sommer, Roman; Hartmann, Laura; Titz, Alexander

    2016-08-16

    Infections with the Gram-negative bacterium Pseudomonas aeruginosa result in a high mortality among immunocompromised patients and those with cystic fibrosis. The pathogen can switch from planktonic life to biofilms, and thereby shields itself against antibiotic treatment and host immune defense to establish chronic infections. The bacterial protein LecA, a C-type lectin, is a virulence factor and an integral component for biofilm formation. Inhibition of LecA with its carbohydrate ligands results in reduced biofilm mass, a potential Achilles heel for treatment. Here, we report the development and optimization of a fluorescence polarization-based competitive binding assay with LecA for application in screening of potential inhibitors. As a consequence of the low affinity of d-galactose for LecA, the fluorescent ligand was optimized to reduce protein consumption in the assay. The assay was validated using a set of known inhibitors of LecA and IC50 values in good agreement with the known Kd values were obtained. Finally, we employed the optimized assay to screen sets of synthetic thio-galactosides and natural blood group antigens and report their structure-activity relationship. In addition, we evaluated a multivalent fluorescent assay probe for LecA and report its applicability in an inhibition assay. PMID:27488655

  1. Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).

    Science.gov (United States)

    Korwar, Sudha; Morris, Benjamin L; Parikh, Hardik I; Coover, Robert A; Doughty, Tyler W; Love, Ian M; Hilbert, Brendan J; Royer, William E; Kellogg, Glen E; Grossman, Steven R; Ellis, Keith C

    2016-06-15

    C-terminal Binding Protein (CtBP) is a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes. Utilizing a crystal structure of CtBP with its substrate 4-methylthio-2-oxobutyric acid (MTOB) and NAD(+) as a guide, we have designed, synthesized, and tested a series of small molecule inhibitors of CtBP. From our first round of compounds, we identified 2-(hydroxyimino)-3-phenylpropanoic acid as a potent CtBP inhibitor (IC50=0.24μM). A structure-activity relationship study of this compound further identified the 4-chloro- (IC50=0.18μM) and 3-chloro- (IC50=0.17μM) analogues as additional potent CtBP inhibitors. Evaluation of the hydroxyimine analogues in a short-term cell growth/viability assay showed that the 4-chloro- and 3-chloro-analogues are 2-fold and 4-fold more potent, respectively, than the MTOB control. A functional cellular assay using a CtBP-specific transcriptional readout revealed that the 4-chloro- and 3-chloro-hydroxyimine analogues were able to block CtBP transcriptional repression activity. This data suggests that substrate-competitive inhibition of CtBP dehydrogenase activity is a potential mechanism to reactivate tumor-suppressor gene expression as a therapeutic strategy for cancer. PMID:27156192

  2. Studies of food folates and folic acid deficiency by radioligand competitive binding assay techniques. Part of a coordinated programme on in vitro assay techniques

    International Nuclear Information System (INIS)

    Conjugese extracted from winged bean or sweet potato leaves was used to release folate from Sri Lankan foodstuffs. Total folate was then estimated by competitive binding assay using goat milk as binding agent. Of 33 foodstuffs investigated, green gram, cow pea, and red gram among the pulses and mukunuvenna, amaranth and centella among the leafy vegetables were shown to be rich sources of folate. Between 20 and 60% of total folate was lost when such foodstuffs were boiled for 60 minutes. It is thus advisable that pulses and leafy vegetables be boiled only for the minimum time necessary for tenderization before consumption

  3. Different sensitivities to competitive inhibition of benzodiazepine receptor binding of {sup 11}C-iomazenil and {sup 11}C-flumazenil in rhesus monkey brain

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Osamu; Hosoi, Rie; Kobayashi, Kaoru [Osaka Univ., Suita (Japan). Medical School; Itoh, Takashi; Gee, A.; Suzuki, Kazutoshi

    2001-04-01

    The in vivo binding kinetics of {sup 11}C-iomazenil were compared with those of {sup 11}C-flumazenil binding in rhesus monkey brain. The monkey was anesthetized with ketamine and intravenously injected with either {sup 11}C-iomazenil or {sup 11}C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0, 5 and 20 {mu}g/kg). The regional distribution of {sup 11}C-iomazenil in the brain was similar to that of {sup 11}C-flumazenil, but the sensitivity of {sup 11}C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of {sup 11}C-flumazenil binding. A significant reduction in {sup 11}C-flumazenil binding in the cerebral cortex was observed with 20 {mu}g/kg of flumazenil, whereas a relatively smaller inhibition of {sup 11}C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that {sup 11}C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain. (author)

  4. Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain

    International Nuclear Information System (INIS)

    The in vivo binding kinetics of 11C-iomazenil were compared with those of 11C-flumazenil binding in rhesus monkey brain. The monkey was anesthetized with ketamine and intravenously injected with either 11C-iomazenil or 11C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0, 5 and 20 μg/kg). The regional distribution of 11C-iomazenil in the brain was similar to that of 11C-flumazenil, but the sensitivity of 11C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of 11C-flumazenil binding. A significant reduction in 11C-flumazenil binding in the cerebral cortex was observed with 20 μg/kg of flumazenil, whereas a relatively smaller inhibition of 11C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that 11C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain. (author)

  5. Competition for in vitro [3H]gibberellin A4 binding in cucumber by gibberellins and their derivatives

    International Nuclear Information System (INIS)

    The gibberellin (GA) binding properties of a cytosol fraction from hypocotyls of cucumber (Cucumis sativus L. cv National Pickling) were examined using a DEAE filter paper assay, [3H]GA4, and over 20 GAs, GA derivatives and other growth regulators. The results demonstrate structural specificity of the binding protein for γ-lactonic C-19 GAs with a 3 β-hydroxyl and a C-6 carboxyl group. Additional hydroxylations of the A, C, or D ring of the ent-gibberellane skeleton and methylation of the C-6 carboxyl impede or abolish binding affinity. Bioassay data are generally supported by the in vitro results but significantly GA9 and GA36, both considered to be precursors of GA4 in cucumber, show no affinity for the binding protein. The results are discussed in relation to the active site of the putative GA4 receptor in cucumber

  6. Competitive Binding Sites of a Ruthenium Arene Anticancer Complex on Oligonucleotides Studied by Mass Spectrometry: Ladder-Sequencing versus Top-Down

    Science.gov (United States)

    Wu, Kui; Hu, Wenbing; Luo, Qun; Li, Xianchan; Xiong, Shaoxiang; Sadler, Peter J.; Wang, Fuyi

    2013-03-01

    We report identification of the binding sites for an organometallic ruthenium anticancer complex [( η 6-biphenyl)Ru(en)Cl][PF6] ( 1; en = ethylenediamine) on the 15-mer single-stranded oligodeoxynucleotides (ODNs), 5'-CTCTCTX7G8Y9CTTCTC-3' [X = Y = T ( I); X = C and Y = A ( II); X = A and Y = T ( III); X = T and Y = A ( IV)] by electrospray ionization mass spectrometry (ESI-MS) in conjunction with enzymatic digestion or tandem mass spectrometry (top-down MS). ESI-MS combined with enzymatic digestion (termed MS-based ladder-sequencing), is effective for identification of the thermodynamically-favored G-binding sites, but not applicable to determine the thermodynamically unstable T-binding sites because the T-bound adducts dissociate during enzymatic digestion. In contrast, top-down MS is efficient for localization of the T binding sites, but not suitable for mapping ruthenated G bases, due to the facile fragmentation of G bases from ODN backbones prior to the dissociation of the phosphodiester bonds. The combination of the two MS approaches reveals that G8 in each ODN is the preferred binding site for 1, and that the T binding sites of 1 are either T7 or T11 on I and IV, and either T6 or T11 on II and III, respectively. These findings not only demonstrate for the first time that T-bases in single-stranded oligonucleotides are kinetically competitive with guanine for such organoruthenium complexes, but also illustrate the relative merits of the combination of ladder-sequencing and top-down MS approaches to elucidate the interactions of metal anticancer complexes with DNA.

  7. A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.

    Science.gov (United States)

    Yin, Liusong; Stern, Lawrence J

    2014-04-01

    HLA-DM (DM) functions as a peptide editor that mediates the exchange of peptides loaded onto MHCII molecules by accelerating peptide dissociation and association kinetics. The relative DM-susceptibility of peptides bound to MHCII molecules correlates with antigen presentation and immunodominance hierarchy, and measurement of DM-susceptibility has been a key effort in this field. Current assays of DM-susceptibility, based on differential peptide dissociation rates measured for individually labeled peptides over a long time base, are difficult and cumbersome. Here, we present a novel method to measure DM-susceptibility based on peptide binding competition assays performed in the presence and absence of DM, reported as a delta-IC(50) (change in 50% inhibition concentration) value. We simulated binding competition reactions of peptides with various intrinsic and DM-catalyzed kinetic parameters and found that under a wide range of conditions the delta-IC(50) value is highly correlated with DM-susceptibility as measured in off-rate assay. We confirmed experimentally that DM-susceptibility measured by delta-IC(50) is comparable to that measured by traditional off-rate assay for peptides with known DM-susceptibility hierarchy. The major advantage of this method is that it allows simple, fast and high throughput measurement of DM-susceptibility for a large set of unlabeled peptides in studies of the mechanism of DM action and for identification of CD4+ T cell epitopes. PMID:24583195

  8. Automated measurement of serum thyroxine with the ''AIRA II,'' as compared with competitive protein binding and radioimmunoassay

    Energy Technology Data Exchange (ETDEWEB)

    Reese, M.G.; Johnson, L.V.R.

    1978-02-01

    Two conventional serum thyroxine assays, run in separate laboratories, one by competitive protein binding and one by radioimmunoassay, were used to evaluate the automated ARIA II (Becton Dickinson Immunodiagnostics) serum thyroxine assay. Competitive protein binding as compared to ARIA II with 111 clinical serum samples gave a slope of 1.04 and a correlation coefficient of 0.94. The radioimmunoassay comparison to ARIA II with 53 clinical serum samples gave a slope of 1.05 and a correlation coefficient of 0.92. The ARIA II inter-assay coefficient of variation for 10 replicates of low, medium, and high thyroxine serum samples was 6.2, 6.0, and 2.9%, respectively, with an inter-assay coefficient of variation among 15 different assays of 15.5, 10.1, and 7.9%. The automated ARIA II, with a 2.2-min cycle per sample, gives results that compare well with those by manual methodology.

  9. Agrobacterium uses a unique ligand-binding mode for trapping opines and acquiring a competitive advantage in the niche construction on plant host.

    Directory of Open Access Journals (Sweden)

    Julien Lang

    2014-10-01

    Full Text Available By modifying the nuclear genome of its host, the plant pathogen Agrobacterium tumefaciens induces the development of plant tumours in which it proliferates. The transformed plant tissues accumulate uncommon low molecular weight compounds called opines that are growth substrates for A. tumefaciens. In the pathogen-induced niche (the plant tumour, a selective advantage conferred by opine assimilation has been hypothesized, but not experimentally demonstrated. Here, using genetics and structural biology, we deciphered how the pathogen is able to bind opines and use them to efficiently compete in the plant tumour. We report high resolution X-ray structures of the periplasmic binding protein (PBP NocT unliganded and liganded with the opine nopaline (a condensation product of arginine and α-ketoglurate and its lactam derivative pyronopaline. NocT exhibited an affinity for pyronopaline (K(D of 0.6 µM greater than that for nopaline (KD of 3.7 µM. Although the binding-mode of the arginine part of nopaline/pyronopaline in NocT resembled that of arginine in other PBPs, affinity measurement by two different techniques showed that NocT did not bind arginine. In contrast, NocT presented specific residues such as M117 to stabilize the bound opines. NocT relatives that exhibit the nopaline/pyronopaline-binding mode were only found in genomes of the genus Agrobacterium. Transcriptomics and reverse genetics revealed that A. tumefaciens uses the same pathway for assimilating nopaline and pyronopaline. Fitness measurements showed that NocT is required for a competitive colonization of the plant tumour by A. tumefaciens. Moreover, even though the Ti-plasmid conjugal transfer was not regulated by nopaline, the competitive advantage gained by the nopaline-assimilating Ti-plasmid donors led to a preferential horizontal propagation of this Ti-plasmid amongst the agrobacteria colonizing the plant-tumour niche. This work provided structural and genetic evidences to

  10. Agrobacterium uses a unique ligand-binding mode for trapping opines and acquiring a competitive advantage in the niche construction on plant host.

    Science.gov (United States)

    Lang, Julien; Vigouroux, Armelle; Planamente, Sara; El Sahili, Abbas; Blin, Pauline; Aumont-Nicaise, Magali; Dessaux, Yves; Moréra, Solange; Faure, Denis

    2014-10-01

    By modifying the nuclear genome of its host, the plant pathogen Agrobacterium tumefaciens induces the development of plant tumours in which it proliferates. The transformed plant tissues accumulate uncommon low molecular weight compounds called opines that are growth substrates for A. tumefaciens. In the pathogen-induced niche (the plant tumour), a selective advantage conferred by opine assimilation has been hypothesized, but not experimentally demonstrated. Here, using genetics and structural biology, we deciphered how the pathogen is able to bind opines and use them to efficiently compete in the plant tumour. We report high resolution X-ray structures of the periplasmic binding protein (PBP) NocT unliganded and liganded with the opine nopaline (a condensation product of arginine and α-ketoglurate) and its lactam derivative pyronopaline. NocT exhibited an affinity for pyronopaline (K(D) of 0.6 µM) greater than that for nopaline (KD of 3.7 µM). Although the binding-mode of the arginine part of nopaline/pyronopaline in NocT resembled that of arginine in other PBPs, affinity measurement by two different techniques showed that NocT did not bind arginine. In contrast, NocT presented specific residues such as M117 to stabilize the bound opines. NocT relatives that exhibit the nopaline/pyronopaline-binding mode were only found in genomes of the genus Agrobacterium. Transcriptomics and reverse genetics revealed that A. tumefaciens uses the same pathway for assimilating nopaline and pyronopaline. Fitness measurements showed that NocT is required for a competitive colonization of the plant tumour by A. tumefaciens. Moreover, even though the Ti-plasmid conjugal transfer was not regulated by nopaline, the competitive advantage gained by the nopaline-assimilating Ti-plasmid donors led to a preferential horizontal propagation of this Ti-plasmid amongst the agrobacteria colonizing the plant-tumour niche. This work provided structural and genetic evidences to support the niche

  11. Dual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics.

    Science.gov (United States)

    Guo, Dong; van Dorp, Erika J H; Mulder-Krieger, Thea; van Veldhoven, Jacobus P D; Brussee, Johannes; Ijzerman, Adriaan P; Heitman, Laura H

    2013-03-01

    The concept of ligand-receptor binding kinetics is emerging as an important parameter in the early phase of drug discovery. Since the currently used kinetic assays are laborious and low throughput, we developed a method that enables fast and large format screening. It is a so-called dual-point competition association assay, which measures radioligand binding at two different time points in the absence or presence of unlabeled competitors. Specifically, this assay yields the kinetic rate index (KRI), which is a measure for the binding kinetics of the unlabeled ligands screened. As a prototypical drug target, the adenosine A(1) receptor (A(1)R) was chosen for assay validation and optimization. A screen with 35 high-affinity A(1)R antagonists yielded seven compounds with a KRI value above 1.0, which indicated a relatively slow dissociation from the target. All other compounds had a KRI value below or equal to 1.0, predicting a relatively fast dissociation rate. Several compounds were selected for follow-up kinetic quantifications in classical kinetic assays and were shown to have kinetic rates that corresponded to their KRI values. The dual-point assay and KRI value may have general applicability at other G-protein-coupled receptors, as well as at drug targets from other protein families. PMID:23093571

  12. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA.

    Science.gov (United States)

    Kuwano, Y; Nishida, K; Kajita, K; Satake, Y; Akaike, Y; Fujita, K; Kano, S; Masuda, K; Rokutan, K

    2015-05-01

    RNA-binding proteins and microRNAs are potent post-transcriptional regulators of gene expression. Human transformer 2β (Tra2β) is a serine/arginine-rich-like protein splicing factor and is now implicated to have wide-ranging roles in gene expression as an RNA-binding protein. RNA immunoprecipitation (RIP) with an anti-Tra2β antibody and microarray analysis identified a subset of Tra2β-associated mRNAs in HCT116 human colon cancer cells, many of which encoded cell death-related proteins including Bcl-2 (B-cell CLL/lymphoma 2). Tra2β knockdown in HCT116 cells decreased Bcl-2 expression and induced apoptosis. Tra2β knockdown accelerated the decay of BCL2α mRNA that encodes Bcl-2 and full-length 3' UTR, while it did not affect the stability of BCL2β mRNA having a short, alternatively spliced 3' UTR different from BCL2α 3' UTR. RIP assays with anti-Tra2β and anti-Argonaute 2 antibodies, respectively, showed that Tra2β bound to BCL2α 3' UTR, and that Tra2β knockdown facilitated association of miR-204 with BCL2α 3' UTR. The consensus sequence (GAA) for Tra2β-binding lies within the miR-204-binding site of BCL2 3' UTR. Mutation of the consensus sequence canceled the binding of Tra2β to BCL2 3' UTR without disrupting miR-204-binding to BCL2 3' UTR. Transfection of an anti-miR-204 or introduction of three-point mutations into the miR-204-binding site increased BCL2 mRNA and Bcl-2 protein levels. Inversely, transfection of precursor miR-204 reduced their levels. Experiments with Tra2β-silenced or overexpressed cells revealed that Tra2β antagonized the effects of miR-204 and upregulated Bcl-2 expression. Furthermore, TRA2β mRNA expression was significantly upregulated in 22 colon cancer tissues compared with paired normal tissues and positively correlated with BCL2 mRNA expression. Tra2β knockdown in human lung adenocarcinoma cells (A549) increased their sensitivity to anticancer drugs. Taken together, our findings suggest that Tra2β regulates apoptosis by

  13. Measurement of adenosine 3':5'-cyclic monophosphate by competitive binding to salt-dissociated protein kinase.

    Science.gov (United States)

    Døskeland, S O; Haga, H J

    1978-08-15

    An assay for cyclic AMP is described which takes advantage of the high affinity of the dissociated receptor moiety of cyclic AMP-dependent protein kinase I for the nucleotide. The kinase is kept dissociated by salt (800 mM-NaCl/30mM-EDTA). In the presence of a simply prepared heat-stable protein fraction the binding reagent is stable for the time needed to reach equilibrium of binding. A simple procedure [precipitation with poly-(ethylene glycol) followed by DEAE-cellulose chromatography] is described for the separation of protein kinase I from other binding proteins for cyclic AMP in rabbit skeletal muscle. The sensitivity, precision, reproducibility and specificity of the assay compared favourably with those of other cyclic AMP assays. The main advantage of the present assay is its resistance towards non-specific interference from a number of salts, tissue-culture media and substances found in crude tissue extracts. The reliability of cyclic AMP measurement directly in crude tissue extracts was ensured by removal of the assayable cyclic AMP with cyclic nucleotide phosphodiesterase digestion or adsorption with antibody against cyclic AMP, by comparison with measurement in tissue extracts purified by chromatography on QAE-Sephadex or sequentially on Dowex 50, and aluminium oxide as well as by dilution and recovery experiments. PMID:213054

  14. Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies.

    Science.gov (United States)

    Ploux, O; Breyne, O; Carillon, S; Marquet, A

    1999-01-01

    8-Amino-7-oxopelargonate synthase catalyzes the first committed step of biotin biosynthesis in micro-organisms and plants. Because inhibitors of this pathway might lead to antibacterials or herbicides, we have undertaken an inhibition study on 8-amino-7-oxopelargonate synthase using six different compounds. d-Alanine, the enantiomer of the substrate of this pyridoxal-5'-phosphate-dependent enzyme was found to be a competitive inhibitor with respect to l-alanine with a Ki of 0.59 mm. The fact that this inhibition constant was four times lower than the Km for l-alanine was interpreted as the consequence of the inversion-retention stereochemistry of the catalyzed reaction. Schiff base formation between l or d-alanine and pyridoxal-5'-phosphate, in the active site of the enzyme, was studied using ultraviolet/visible spectroscopy. It was found that l and d-alanine form an external aldimine with equilibrium constants K = 4.1 mm and K = 37.8 mm, respectively. However, the equilibrium constant for d-alanine aldimine formation dramatically decreased to 1.3 mm in the presence of saturating concentration of pimeloyl-CoA, the second substrate. This result strongly suggests that the binding of pimeloyl-CoA induces a conformational change in the active site, and we propose that this new topology is complementary to d-alanine and to the putative reaction intermediate since they both have the same configuration. (+/-)-8-Amino-7-oxo-8-phosphonononaoic acid (1), the phosphonate derivative of the intermediate formed during the reaction, was our most potent inhibitor with a Ki of 7 microm. This compound behaved as a reversible slow-binding inhibitor, competitive with respect to l-alanine. Kinetic investigation showed that this slow process was best described by a one-step mechanism (mechanism A) with the following rate constants: k1 = 0.27 x 103 m-1.s-1, k2 = 1.8 s-1 and half-life for dissociation t1/2 = 6.3 min. The binding of compound 1 to the enzyme was also studied using

  15. [123I]Iodobenzamide binding to the rat dopamine D2 receptor in competition with haloperidol and endogenous dopamine - an in vivo imaging study with a dedicated small animal SPECT

    International Nuclear Information System (INIS)

    This study assessed [123I]iodobenzamide binding to the rat dopamine D2 receptor in competition with haloperidol and endogenous dopamine using a high-resolution small animal SPECT. Subsequent to baseline quantifications of D2 receptor binding, imaging studies were performed on the same animals after pre-treatment with haloperidol and methylphenidate, which block D2 receptors and dopamine transporters, respectively. Striatal baseline equilibrium ratios (V3'') of [123I]iodobenzamide binding were 1.42±0.31 (mean±SD). After pre-treatment with haloperidol and methylphenidate, V3'' values decreased to 0.54±0.46 (p123I]iodobenzamide binding induced by pre-treatment with haloperidol reflects D2 receptor blockade, whereas the decrease in receptor binding induced by pre-treatment with methylphenidate can be interpreted in terms of competition between [123I]IBZM and endogenous dopamine. Findings show that multiple in vivo measurements of [123I]iodobenzamide binding to D2 receptors in competition with exogenous and endogenous ligands are feasible in the same animal. This may be of future relevance for the in vivo evaluation of novel radioligands as well as for studying the interrelations between pre- and/or postsynaptic radioligand binding and different levels of endogenous dopamine. (orig.)

  16. Albumin-coated SPIONs: an experimental and theoretical evaluation of protein conformation, binding affinity and competition with serum proteins

    Science.gov (United States)

    Yu, Siming; Perálvarez-Marín, Alex; Minelli, Caterina; Faraudo, Jordi; Roig, Anna; Laromaine, Anna

    2016-07-01

    The variety of nanoparticles (NPs) used in biological applications is increasing and the study of their interaction with biological media is becoming more important. Proteins are commonly the first biomolecules that NPs encounter when they interact with biological systems either in vitro or in vivo. Among NPs, super-paramagnetic iron oxide nanoparticles (SPIONs) show great promise for medicine. In this work, we study in detail the formation, composition, and structure of a monolayer of bovine serum albumin (BSA) on SPIONs. We determine, both by molecular simulations and experimentally, that ten molecules of BSA form a monolayer around the outside of the SPIONs and their binding strength to the SPIONs is about 3.5 × 10-4 M, ten times higher than the adsorption of fetal bovine serum (FBS) on the same SPIONs. We elucidate a strong electrostatic interaction between BSA and the SPIONs, although the secondary structure of the protein is not affected. We present data that supports the strong binding of the BSA monolayer on SPIONs and the properties of the BSA layer as a protein-resistant coating. We believe that a complete understanding of the behavior and morphology of BSA-SPIONs and how the protein interacts with SPIONs is crucial for improving NP surface design and expanding the potential applications of SPIONs in nanomedicine.The variety of nanoparticles (NPs) used in biological applications is increasing and the study of their interaction with biological media is becoming more important. Proteins are commonly the first biomolecules that NPs encounter when they interact with biological systems either in vitro or in vivo. Among NPs, super-paramagnetic iron oxide nanoparticles (SPIONs) show great promise for medicine. In this work, we study in detail the formation, composition, and structure of a monolayer of bovine serum albumin (BSA) on SPIONs. We determine, both by molecular simulations and experimentally, that ten molecules of BSA form a monolayer around the

  17. Influence of cooling rate on the ability of frozen-thawed sperm to bind to heterologous zona pellucida, as assessed by competitive in vitro binding assays in the ocelot (Leopardus pardalis) and tigrina (Leopardus tigrinus).

    Science.gov (United States)

    Baudi, D L K; Jewgenow, K; Pukazhenthi, B S; Spercoski, K M; Santos, A S; Reghelin, A L S; Candido, M V; Javorouski, M L; Müller, G; Morais, R N

    2008-01-15

    We evaluated the influence of two cooling rates (from 25 to 5 degrees C) on post-thaw function of frozen sperm in ocelots (Leopardus pardalis; n=3 males) and tigrinas (Leopardus tigrinus; n=4 males). Seven normospermic (>70% normal sperm) electroejaculates from each species were diluted with a 4% glycerol freezing medium, divided into two aliquots, and assigned to one of two cooling rates: fast or slow (0.7 or 0.16 degrees C/min, respectively). Sperm motility index (SMI) and percentage of sperm with an intact acrosome were assessed before freezing and after thawing, and the ability of sperm to bind to the zona pellucida of IVM domestic cat oocytes were assessed in a competitive in vitro sperm-binding assay. Regardless of the cooling rate, frozen-thawed sperm from both species exhibited a SMI of 50; approximately 20 and approximately 32% of post-thaw sperm had an intact acrosome in ocelots and tigrinas, respectively (P<0.05). The mean (+/-S.E.M.) number of sperm bound per oocyte was higher for fast-cooled (8.5+/-1.3) than slow-cooled (2.5+/-0.3; P<0.01) ocelot sperm. In contrast, more tigrina sperm bound to domestic cat oocytes when cooled slowly versus quickly (5.8+/-0.9 versus 2.7+/-0.4, P<0.05). In conclusion, cryopreservation decreased sperm function in both species, and the oocyte-binding assay was the most efficient method to detect functional differences in post-thaw sperm. PMID:17977588

  18. Application of the local-bulk partitioning and competitive binding models to interpret preferential interactions of glycine betaine and urea with protein surface.

    Science.gov (United States)

    Felitsky, Daniel J; Record, M Thomas

    2004-07-20

    Two thermodynamic models have been developed to interpret the preferential accumulation or exclusion of solutes in the vicinity of biopolymer surface and the effects of these solutes on protein processes. The local-bulk partitioning model treats solute (and water) as partitioning between the region at/or near the protein surface (the local domain) and the bulk solution. The solvent exchange model analyzes a 1:1 competition between water and solute molecules for independent surface sites. Here we apply each of these models to interpret thermodynamic data for the interactions of urea and the osmoprotectant glycine betaine (N,N,N-trimethylglycine; GB) with the surface exposed in unfolding the marginally stable lacI HTH DNA binding domain. The partition coefficient K(P) quantifying accumulation of urea at this protein surface (K(P) approximately equal 1.1) is only weakly dependent on urea concentration up to 6 M urea. However, K(P) quantifying exclusion of GB from the vicinity of this protein surface increases from 0.83 (extrapolated to 0 M GB) to 1.0 (indicating that local and bulk GB concentrations are equal) at 4 M GB (activity > 40 M). We interpret the significant concentration dependence of K(P) for GB, predicted to be general for excluded, nonideal solutes such as GB, as a modest (8%) attenuation of the GB concentration dependence of solute nonideality in the local domain relative to that in the bulk solution. Above 4 M, K(P) for the interaction of GB with the surface exposed in protein unfolding is predicted to exceed unity, which explains the maximum in thermal stability observed for RNase and lysozyme at 4 M GB (Santoro, M. M., Liu, Y. F., Khan, S. M. A., Hou, L. X., and Bolen, D. W. (1992) Biochemistry 31, 5278-5283). Both thermodynamic models provide good two-parameter fits to GB and urea data for lacI HTH unfolding over a wide concentration range. The solute partitioning model allows for a full spectrum of attenuation effects in the local domain

  19. [{sup 123}I]Iodobenzamide binding to the rat dopamine D{sub 2} receptor in competition with haloperidol and endogenous dopamine - an in vivo imaging study with a dedicated small animal SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaus, Susanne; Larisch, Rolf; Wirrwar, Andreas; Jamdjeu-Noune, Marlyse; Antke, Christina; Beu, Markus; Mueller, Hans-Wilhelm [Heinrich-Heine University, Clinic of Nuclear Medicine, Duesseldorf (Germany); Schramm, Nils [Research Center Juelich, Central Laboratory for Electronics, Juelich (Germany)

    2005-11-01

    This study assessed [{sup 123}I]iodobenzamide binding to the rat dopamine D{sub 2} receptor in competition with haloperidol and endogenous dopamine using a high-resolution small animal SPECT. Subsequent to baseline quantifications of D{sub 2} receptor binding, imaging studies were performed on the same animals after pre-treatment with haloperidol and methylphenidate, which block D{sub 2} receptors and dopamine transporters, respectively. Striatal baseline equilibrium ratios (V{sub 3}{sup ''}) of [{sup 123}I]iodobenzamide binding were 1.42{+-}0.31 (mean{+-}SD). After pre-treatment with haloperidol and methylphenidate, V{sub 3}{sup ''} values decreased to 0.54{+-}0.46 (p<0.0001) and 0.98{+-}0.48 (p=0.009), respectively. The decrease in [{sup 123}I]iodobenzamide binding induced by pre-treatment with haloperidol reflects D{sub 2} receptor blockade, whereas the decrease in receptor binding induced by pre-treatment with methylphenidate can be interpreted in terms of competition between [{sup 123}I]IBZM and endogenous dopamine. Findings show that multiple in vivo measurements of [{sup 123}I]iodobenzamide binding to D{sub 2} receptors in competition with exogenous and endogenous ligands are feasible in the same animal. This may be of future relevance for the in vivo evaluation of novel radioligands as well as for studying the interrelations between pre- and/or postsynaptic radioligand binding and different levels of endogenous dopamine. (orig.)

  20. Comparison of Commercial Latex Agglutination and Sandwich Enzyme Immunoassays with a Competitive Binding Inhibition Enzyme Immunoassay for Detection of Antigenemia and Antigenuria in a Rabbit Model of Invasive Aspergillosis

    OpenAIRE

    Hurst, Steven F.; Reyes, Guadalupe H.; McLaughlin, David W.; Reiss, Errol; Morrison, Christine J.

    2000-01-01

    A commercial latex agglutination assay (LA) and a sandwich enzyme immunoassay (SEIA) (Sanofi Diagnostics Pasteur, Marnes-la-Coquette, France) were compared with a competitive binding inhibition assay (enzyme immunoassay [EIA]) to determine the potential uses and limitations of these antigen detection tests for the sensitive, specific, and rapid diagnosis of invasive aspergillosis (IA). Toward this end, well-characterized serum and urine specimens were obtained by using a rabbit model of IA. S...

  1. In vitro binding of leukotriene B4 (LTB4) to human serum albumin: evidence from spectroscopic, molecular modeling, and competitive displacement studies.

    Science.gov (United States)

    Zsila, Ferenc; Bikádi, Zsolt; Lockwood, Samuel F

    2005-08-15

    Circular dichroism (CD) and UV absorption spectroscopy were utilized for the first time to investigate the interaction between leukotriene B4 (LTB4) and human serum albumin (HSA) in vitro. The weak intrinsic CD signal of LTB4 was enhanced fivefold in the presence of HSA. The red-shifted, hypochromic, and reduced vibrational fine structure of the ligand/protein UV absorption spectrum indicated complexation of the two molecules in solution. Results obtained from CD titration experiments were subjected to non-linear regression analysis to estimate the binding parameters (Ka = 6.7 x 10(4) M(-1), n = 1). Palmitic acid strongly decreased the induced CD signal of the LTB4/HSA complex, suggesting the role of a high-affinity fatty acid HSA binding site in the leukotriene complexation. Molecular modeling calculations based on the crystal structure of HSA predicted that the long-chain fatty acid site that overlaps with drug binding site II in subdomain IIIA was the most likely binding location for LTB4. Using the drug site II-specific marker ligand rac-ibuprofen, this prediction was confirmed with induced-CD displacement measurements. To the authors' knowledge, the current study represents the first demonstration of binding of LTB4 to HSA in vitro and has implications for the biological transport of this important pro-inflammatory mediator in vivo. PMID:15993588

  2. Competitive Intelligence.

    Science.gov (United States)

    Bergeron, Pierrette; Hiller, Christine A.

    2002-01-01

    Reviews the evolution of competitive intelligence since 1994, including terminology and definitions and analytical techniques. Addresses the issue of ethics; explores how information technology supports the competitive intelligence process; and discusses education and training opportunities for competitive intelligence, including core competencies…

  3. Retail competition

    International Nuclear Information System (INIS)

    Retail competition as the cornerstone of a competitive electricity marketplace was the subject of the seventh in the series of policy discussion papers developed at the Market Design Conference. Concern was expressed that because of the complexities involved in market design and technical implementation, the retail competition may lag behind other elements of the implementation of the new market design. A variety of key issues were debated, including the role of physical versus financial contracts, the form of retail competition and financial settlement systems in the short term, the requirement to separate 'competitive' (metering, billing, maintenance, consumer education) from non-competitive' (the transmission wires) services and the role of municipal electric utilities. It was agreed that the IMO should play an important role in defining and enforcing the separation of services, and that as a general rule, the development of policy in this area should be guided by the principle of maximizing the potential for competition

  4. Competitive intelligence

    OpenAIRE

    Matsenko, Olga

    2009-01-01

    Competitive intelligence (CI) helps company to make right strategic decision in uncertain competitive environment. Many companies do different kinds of marketing research, but still have not adopted CI tools yet, especially in those countries where they have just started to implement instruments of free market economy. This could be related to Russian situation. The thesis is organized into three chapters. Competitive intelligence theory is explained in the first chapter. In the second chapte...

  5. Competitiveness factors

    OpenAIRE

    Popa Liliana-Viorica

    2012-01-01

    Porter's theory supports the idea that, despite the globalization of production and trade, the competitive advantage is created in a national framework, nations, through their institutional, natural, cultural, economic characteristics ultimately determining the development of certain economic activities. The factors considered by Porter as determinants for the competitive advantage are grouped in four categories, the linkages between them being important as well

  6. Pop competitiveness

    OpenAIRE

    Roberto Cellino; Anna Soci

    2002-01-01

    Very few economic terms are used as much as competitiveness in economics. This article deals with the different meanings of competitiveness, at the level of a firm, at the level of the local area, and at the level of the country. It analyzes the problems of consistency among the available definitions and among the indicators used to measurecompetitiveness.

  7. Delaware's Competition

    OpenAIRE

    Roe, Mark J.

    2003-01-01

    One of corporate law's enduring issues has been the extent to which state-to-state competitive pressures on Delaware make for a race to the top or the bottom. States, or at least some of them, are said to compete with their corporate law to get corporate tax revenue and ancillary benefits. Delaware has "won" that race, with the overwhelming number of American large corporations chartering there. Here I argue that this long-standing debate is misconceived. Delaware's chief competitive pressure...

  8. Competitive Pricing

    OpenAIRE

    Antonio Villar

    2007-01-01

    Competitive pricing is a pricing rule that combines two principles that are present in competitive markets. The profit principle (an action will be chosen only if it yields maximal payoffs), and the scarcity principle (markets make expensive those commodities that restrict production possibilities). It is shown that, under standard assumptions, these principles imply profit maximization at given prices. But also that they can be applied to economies with non-convex production sets (e.g. firms...

  9. Competition Regime

    OpenAIRE

    Danilo Icaza Ortiz

    2013-01-01

    This paper is a review of the competition regime works of various authors, published under the auspices of the University of the Hemispheres and the Corporation for Studies and Publications. Analyzes the structure, the general concepts, case law taken for development. Includes comments on the usefulness of this work for the study of competition law and the contribution to the lawyers who want to practice in this branch of economic law.

  10. Competition Regime

    Directory of Open Access Journals (Sweden)

    Danilo Icaza Ortiz

    2013-01-01

    Full Text Available This paper is a review of the competition regime works of various authors, published under the auspices of the University of the Hemispheres and the Corporation for Studies and Publications. Analyzes the structure, the general concepts, case law taken for development. Includes comments on the usefulness of this work for the study of competition law and the contribution to the lawyers who want to practice in this branch of economic law.

  11. Case competitions

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram

    2009-01-01

    The paper presents and discusses a teaching project with case competitions for MA students of specialised translation at the Aarhus School of Business, Aarhus University. Drawing on a series of online questionnaires, the paper ascertains how the project was evaluated by the participating students...

  12. EDITORIAL: Physics competitions Physics competitions

    Science.gov (United States)

    Jordens, H.; Mathelitsch, L.

    2009-11-01

    1. Physics competitions: aims and realizations One aim of physics competitions is to increase the interest of young students, primarily at upper secondary level, to physics and natural sciences in general. A competition has motivational aspects known usually from sports events or games—comparing one's own ability with others, of course with the desire to be better and to win. If competitions reach nationwide and even international levels, additional stimulation is created. Competitions provide greatest attraction to possible winners, to the group of gifted people in a particular field. This implies that science contests are excellent tools for the promotion of talented students. Traditional teaching has been shown to have problems in supporting this group of students. Very often teachers are overstretched with the demands of teaching both low- and high-level students. Extracurricular activities are therefore a good chance to relieve the teacher, and to give talented students the opportunity for appropriate training and challenge. The competitions, however, have a broader impact and address more young people than one might guess from the statements above. Training courses and selection at school level give a larger group of students extra and, to some extent, complimentary education in physics. The degree of complexity of the tasks corresponds very often to the standards of the next level of education in the school system. Interestingly, many physics competitions have their origin in countries beyond the former Iron Curtain. They started as regional and national tournaments, were joined by neighbouring countries and have grown, in some cases, to events with participants from more than 80 countries. Although the features mentioned above are common to the different competitions, there are distinct differences between them [1]. The International Physics Olympiad (IPhO) is the oldest international physics competition for students at upper secondary level [2]. It dates

  13. EDITORIAL: Physics competitions Physics competitions

    Science.gov (United States)

    Jordens, H.; Mathelitsch, L.

    2010-07-01

    This editorial opens the second special section on physics competitions in European Journal of Physics. In the first section last year, we asked for feedback on the idea of such a section and on the content of the articles. We received no answer whatsoever, which can be interpreted in two ways: the section is not interesting enough to raise motivation for feedback, or the reader is satisfied. Having no indication which scenario is the correct one, we are optimistic and favour the second. The section at hand contains three articles. Again, as last year, the organizer of the annual Olympiad reports on tasks and outcomes of this competition. The Olympiad took place in Merida, Mexico, and was by far the largest event with 316 contestants from 68 countries. Again, the predominance of Asian/Chinese students was manifest, showing how serious the training is taken by both their authorities and students. Unfortunately, the winners of the last International Young Physicists' Tournament (IYPT), the team from Korea, did not accept the offer to report on their prize-winning contribution. We are thankful that two students from Austria, who achieved second place with their team, took over and reported on the task which they presented in the finals of the competition. It connects the fields of sport and physics and explains a special move in skateboarding. The third contribution introduces a different competition, 'International Conference of Young Scientists'. On one hand, as in the Olympiad, it addresses individuals, not teams. On the other, as in the IYPT, students have several months to prepare and also the quality of the presentation is an important element of the judgment. In fact, this competition comes closer to real scientific research compared to the other events. Finally and again, we hope that this section will serve several purposes: To show the competitions as a very important tool in the support of gifted students. To raise awareness amongst university teachers, and

  14. Logo competition

    CERN Multimedia

    Staff Association

    2013-01-01

    Award of the prizes The price ceremony for the Staff Association’s new logo competition which took place on Friday 1st March at 5 p.m. was a big success. The first prize, an Ezee Suisse electric bike, was won by Paulo Rios, from Portugal. In his absence, the bike was handed to his brother Vitor. The other five winners of the competition also received their prize: Go Sport vouchers. A peize draw was then organized to award 22 other participants with prizes offered by our commercial partners (Aquaparc, BCGE, L’Occitane, Passeport Gourmand, Sephora, Theater La Comédie de Genève), whom we would like to warmly thank. After all prices were distributed the evening continued with discussions around a friendly drink.

  15. Competitive Framing

    OpenAIRE

    Ran Spiegler

    2014-01-01

    I present a simple framework for modeling two-firm market competition when consumer choice is "frame-dependent", and firms use costless "marketing messages" to influence the consumer's frame. This framework embeds several recent models in the "behavioral industrial organization" literature. I identify a property that consumer choice may satisfy, which extends the concept of Weighted Regularity due to Piccione and Spiegler (2012), and provide a characterization of Nash equilibria under this pr...

  16. EDITORIAL: Physics competitions Physics competitions

    Science.gov (United States)

    Jordens, H.; Mathelitsch, L.

    2011-07-01

    International tests on competences, such as TIMSS or PISA, and knowledge of young students have revealed low average scores in many countries, often unexpectedly. One effective measure to increase the average standard of a population is to bring the last third of the group to a higher level. Therefore, many nations put some effort into this activity. This brings the danger that not enough attention is paid to students at the other end, those who are talented. Indeed, it is a very difficult task for a teacher to support the less able and at the same time challenge the gifted students, to lead them to the limits of their abilities and provide for a smooth transition to university study. Physics competitions have been proven to fulfil these last demands to a large degree, and therefore are an important additional and, to some extent, complementary tool for the promotion of talented students. This third special section on physics competitions in European Journal of Physics contains three papers, each dealing with a different form of science contest. The first continues the series of presentations of tasks performed at the International Young Physicists' Tournament, which was held in Vienna in 2011. First place went to the team from Singapore, and they have put their investigation on vertical oscillations of coupled magnets into written form (not required by the tournament, where an oral presentation and a defence and discussion are the central aspects). Their paper shows how rich in physics this problem is, and what level of solutions high-school students can already achieve. Sadly, those responsible for the organization of last year's International Physics Olympiad did not provide us with a report on this competition. This is unfortunate, since the Olympiad in Zagreb was very successful and, in particular, the experimental tasks were creative and demanding. Very similar to the aims and the execution of the Physics Olympiad is the International Olympiad on Astronomy

  17. The future of competitions

    DEFF Research Database (Denmark)

    Bates, Gary; Jensen, Boris Brorman; Miessen, Markus

    2010-01-01

    We wanted to explore the potential of the competition. The question we asked ourselves was if the competition can generate new, relevant and critical ideas within architecture? We organized an idea competition about the architectural competition....

  18. Competitive Intelligence

    OpenAIRE

    Pleško, Tomáš

    2011-01-01

    Diplomová práce „Competitive Intelligence“ pojednává o využití metod konkurenčního zpravodajství na případu konkrétní firmy. Po definování základních termínů a principů konkurenčního zpravodajství, provedeme analýzu situace firmy a navrhneme konkrétní postupy jak krizovou situaci řešit. K analýze použijeme údaje poskytnuté jak firmou samotnou, tak i z veřejně dostupných zdrojů informací. V práci se dále věnujeme implementaci metod konkurenčního zpravodajství do rozhodovacích mechanismů společ...

  19. Lunabotics Mining Competition

    Science.gov (United States)

    Mueller, Rob; Murphy, Gloria

    2010-01-01

    This slide presentation describes a competition to design a lunar robot (lunabot) that can be controlled either remotely or autonomously, isolated from the operator, and is designed to mine a lunar aggregate simulant. The competition is part of a systems engineering curriculum. The 2010 competition winners in five areas of the competition were acknowledged, and the 2011 competition was announced.

  20. Competitive spirit

    Science.gov (United States)

    2000-01-01

    Leicester University will host the 65 international teams of students who will assemble in July for this year's International Physics Olympiad . The last time the Olympiad came to the UK was in 1986 in London, and it was the notable enthusiasm of the Leicester Physics and Astronomy department which persuaded the Olympiad Committee to give them the chance of organizing the prestigious event. The students taking part from all over the world are studying physics at A-level or an equivalent standard and they will take part in an intellectual marathon of theoretical and practical examinations. Each national team comprises five students selected from three rounds of competition and the teams will receive an official welcome from the city, as well as opportunities to visit some of the important educational and cultural centres of the surrounding region. The finalists will also be able to test their skills and initiative at the Challenger Learning Centre, which forms part of Leicester's new National Space Science Centre. Specific information on the event can be found on the Olympiad-2000 website at www.star.le.ac.uk/IphO-2000 . The Rudolf Ortvay problem solving contest in physics, which takes place in November, is a tradition of Eötvös University in Budapest, Hungary. The competition was first opened to international participants in 1998, enabling students from universities around the world to show their knowledge, ingenuity, problem-solving skills and physical insight into problems that are far beyond routine level. The problems (30 - 35 each year) are chosen from different branches of theoretical as well as applied physics. They have varying levels of difficulty, and every contestant can send solutions for ten problems. The focus is not on school-level problem-solving routines but rather on the `physical' way of thinking, recognition of the heart of the problem and an appropriate choice of mathematics. The majority of the assigned problems are original, few having

  1. COMPETITIVENESS AND SUPPORTING THE BUSINESS COMPETITIVENESS

    OpenAIRE

    Mester Liana-Eugenia; Bugnar Nicoleta-Georgeta

    2014-01-01

    Competitiveness designates efficiency, productivity, success, adaptability, quality products, optimum costs. Competitiveness is a complex concept which defines the ability of a firm or country to cope with actual or potential competition companies or countries on a particular market, on the world market respectively and it is synonymous with economic efficiency; competitiveness reflects a certain state of the economic activity arising from a certain resource consumption in order to achieve ec...

  2. Competition Policy in Turkey

    OpenAIRE

    Kulaksizoglu, Tamer

    2004-01-01

    This paper evaluates the current competition policy framework in Turkey. A brief history of competition policy is presented. An account of the Law on the Protection of Competition, the main law on competition in Turkey, is given. The structure of the Competition Authority, the body responsi- ble for applying the Law, and the way the enforcement system works are explained. Detailed statistics are given about all the cases submitted to the Competition Authority by 2002. Accoun...

  3. Competition and Poverty

    OpenAIRE

    Begazo, Tania; Nyman, Sara

    2016-01-01

    A literature review shows competition policy reforms can deliver benefits for the poorest households and improve income distribution. A lack of competition in food markets hurts the poorest households the most. Competition in input markets and between buyers helps farmers and small businesses. And more competitive markets bolster job growth over the longer term. More research is needed, ho...

  4. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors.

    Science.gov (United States)

    Jeon, Bu-Nam; Yoo, Jung-Yoon; Choi, Won-Il; Lee, Choong-Eun; Yoon, Ho-Geun; Hur, Man-Wook

    2008-11-28

    FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of FBI-1 is increased in many cancer tissues. We found that FBI-1 potently represses transcription of the Rb gene, a tumor suppressor gene important in cell cycle arrest. FBI-1 binds to four GC-rich promoter elements (FREs) located at bp -308 to -188 of the Rb promoter region. The Rb promoter also contains two Sp1 binding sites: GC-box 1 (bp -65 to -56) and GC-box 2 (bp -18 to -9), the latter of which is also bound by FBI-1. We found that FRE3 (bp -244 to -236) is also a Sp1 binding element. FBI-1 represses transcription of the Rb gene not only by binding to the FREs, but also by competing with Sp1 at the GC-box 2 and the FRE3. By binding to the FREs and/or the GC-box, FBI-1 represses transcription of the Rb gene through its POZ-domain, which recruits a co-repressor-histone deacetylase complex and deacetylates histones H3 and H4 at the Rb gene promoter. FBI-1 inhibits C2C12 myoblast cell differentiation by repressing Rb gene expression. PMID:18801742

  5. Competition in Japan

    OpenAIRE

    Porter, Michael E.; Mariko Sakakibara

    2004-01-01

    This article examines competition in Japan and its link to postwar economic prosperity. While Japan's industrial structure and competition policy seem to indicate that competition in Japan has been less intense, the empirical evidence does not support this conclusion. The sectors in which competition was restricted prove to be those where Japan was not internationally successful. In the internationally successful sectors, internal competition in Japan was invariably fierce. While the level of...

  6. Securitization, Competition and Monitoring.

    OpenAIRE

    Ahn, J-H; Breton, R.

    2013-01-01

    We analyze the impact of loan securitization on competition in the loan market. Using a dynamic loan market competition model where borrowers face both exogenous and endogenous costs to switch between banks, we uncover a competition softening effect of securitization that allows banks to extract rents in the primary loan market. By reducing monitoring incentives, securitization mitigates winner’s curse effects in future stages of competition thereby decreasing ex ante competition for initial ...

  7. Methods of Measuring Competitiveness

    OpenAIRE

    Podaºcã Raluca

    2012-01-01

    Any approach to measuring competitiveness and competitive advantages must take account of one hand of the covered analysis: microeconomic, mezoeconomic, macroeconomic, and on the other hand that they are the result of many variables that are interconditioned directly or indirectly. Measurement methods attempt to quantify the impact of competitiveness and the variables considered relevant. Among all methods of measuring global competitiveness stands Global Competitiveness Index and Economic Fr...

  8. Evaluating competitiveness of airports - Airport competitiveness index

    OpenAIRE

    Grancay, Martin

    2009-01-01

    The paper introduces a concept of airport competitiveness index. The index consists of numerous indicators grouped into four categories: market potential, infrastructure, charges and recent traffic results. Another important factor we take into account is safety. We find that from the selected sample the most competitive airports are Singapore Changi, New York Kennedy, Newark Liberty and Dubai International. U.S. and South-East Asian airports in general are among the most competitive.

  9. COMPETITIVENESS AND SUPPORTING THE BUSINESS COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Mester Liana-Eugenia

    2014-12-01

    Full Text Available Competitiveness designates efficiency, productivity, success, adaptability, quality products, optimum costs. Competitiveness is a complex concept which defines the ability of a firm or country to cope with actual or potential competition companies or countries on a particular market, on the world market respectively and it is synonymous with economic efficiency; competitiveness reflects a certain state of the economic activity arising from a certain resource consumption in order to achieve economic goods. Supporting the national competitiveness and flexibility is aimed at a sustained increase in productivity relying on the diversification and the innovation of the domestic industrial base. The Global Competitiveness Report 2011-2012 ranks Romania as the 77th out of 142 assessed economies. Romania has access to a large market and free trade area, which makes it attractive for many foreign companies, but Romania needs a coherent economic policy that changes the approach used today - from the traditionalist design of restructuring following the resources and, therefore, related to the comparative advantage to finding solutions that stimulate the activities based on knowledge and information so that they allow the emphasis of the competitive advantages. This paper aims to identify the factors and reasons that gave rise to the level of competitiveness for some activities or fields of activities from the economy of Romania during the reporting period, as well as the possibilities that would lead to increasing and supporting the competitiveness of the national economy.

  10. Competitive strategy : Sorrin Puutarha

    OpenAIRE

    Haaristo, Emilia

    2010-01-01

    The thesis handles the fresh food product industry in Finland and especially one company operating in the industry and its competitive position. Sorrin Puutarha manufactures ready-to-use fresh cut salad bag, which is sold in the grocery stores. The objective of the thesis was to find competitive advantages of the case company. Once the competitive advantages were identified the purpose was to choose a fitting competitive strategy that would strengthen those advantages. The field study was con...

  11. Strategizing for Intense Competition.

    Science.gov (United States)

    Hahn, William; Bourgeois, Ernest J., Jr.

    1999-01-01

    Examines trend toward more aggressive student recruiting strategies by colleges and universities, applying a model that assesses five competitive forces-cause and effect of competition, the expanding marketplace, substitute products, buyer power, and supplier power, and examines various strategies for dealing with these competitive forces, such as…

  12. Competitive Anxiety in Sport.

    Science.gov (United States)

    Martens, Rainer; And Others

    This book is a comprehensive review of competitive anxiety research that has used the Sport Competition Anxiety Test, or SCAT (a trait scale), and the Competitive State Anxiety Inventory-2 (CSAI-2). The book describes the theoretical basis and development procedures for both scales, including detailed information on reliability and validity. In…

  13. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor Suppressor Rb Gene via Binding Competition with Sp1 and Recruitment of Co-repressors*S⃞

    OpenAIRE

    Jeon, Bu-Nam; Yoo, Jung-Yoon; Choi, Won-Il; Lee, Choong-Eun; Yoon, Ho-Geun; Hur, Man-Wook

    2008-01-01

    FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of FBI-1 is increased in many cancer tissues. We found that FBI-1 potently represses transcription of the Rb gene, a tumor suppressor gene important in cell cycle arrest. FBI-1 binds to four GC-rich promoter elements (FREs) located at ...

  14. A computational model for feature binding

    Institute of Scientific and Technical Information of China (English)

    SHI ZhiWei; SHI ZhongZhi; LIU Xi; SHI ZhiPing

    2008-01-01

    The "Binding Problem" is an important problem across many disciplines, including psychology, neuroscience, computational modeling, and even philosophy. In this work, we proposed a novel computational model, Bayesian Linking Field Model, for feature binding in visual perception, by combining the idea of noisy neuron model, Bayesian method, Linking Field Network and competitive mechanism.Simulation Experiments demonstrated that our model perfectly fulfilled the task of feature binding in visual perception and provided us some enlightening idea for future research.

  15. A computational model for feature binding

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The "Binding Problem" is an important problem across many disciplines, including psychology, neuroscience, computational modeling, and even philosophy. In this work, we proposed a novel computational model, Bayesian Linking Field Model, for feature binding in visual perception, by combining the idea of noisy neuron model, Bayesian method, Linking Field Network and competitive mechanism. Simulation Experiments demonstrated that our model perfectly fulfilled the task of feature binding in visual perception and provided us some enlightening idea for future research.

  16. Architectural Competition and BIM

    DEFF Research Database (Denmark)

    Sørensen, Nils Lykke; Frandsen, Anne Kathrine; Øien, Turid Borgestrand

    2015-01-01

    on architecturalcompetitions, a series of interviews was conducted with building clients as well as architects, focusing on the impact of the above-mentioned changes within the building sector on architectural competitions as an institution. In the interviews, ICT and notleast BIM was a recurring...... clients, architects and client consultants) and the applied technologies (competition forms, ICT tools, directives) in architectural competitions in a theoretical actor-network perspective. The diverging understandings of the role of BIM are demonstrating one of many negotiations in progress in the...... network of architectural competitions. BIM is transformed from an inscription device visually representing the competition proposals to form an actant that challenges the very concept of architectural competition. The objective of the paper is to contribute to theunderstanding of BIM used in the kind of...

  17. Binding Procurement

    Science.gov (United States)

    Rao, Gopalakrishna M.; Vaidyanathan, Hari

    2007-01-01

    This viewgraph presentation reviews the use of the binding procurement process in purchasing Aerospace Flight Battery Systems. NASA Engineering and Safety Center (NESC) requested NASA Aerospace Flight Battery Systems Working Group to develop a set of guideline requirements document for Binding Procurement Contracts.

  18. Hotel Competitiveness Measurement Methods

    OpenAIRE

    Katalin Juhasz-Dora

    2015-01-01

    Competitiveness is becoming a very common expression used in business administration. The definition and its application still raises some questions due to the complexity of its meaning. The role of the measurement of competitiveness and its effect on performance and profitability is increasing in the field of hospitality and tourism as well. The measurement of hotel competitiveness is a current issue in business life due to globalization, sharing economy and the change in the consumber habit...

  19. Platform Competition in Telecommunications

    OpenAIRE

    Church, Jeffrey; Gandal, Neil

    2004-01-01

    In this Paper we consider the economics of platform competition in telecommunications. Platform competition occurs when different, sometimes incompatible, technologies compete to provide telecommunications services to end-users. Battles between competing technologies have been an important feature of telecommunications in the last twenty or so years. Examples of platform competition in telecommunications include wireless vs. wireline networks, competing wireless options, such as satellite vs....

  20. Multinationals and Institutional Competitiveness

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer; Morgan, Glenn

    This article discusses how institutional competitiveness and multinationals are mutually enriching concepts. Seen from the perspective of Multinationals, institutional competitiveness becomes expressed at two levels. At the level of corporate HQs institutional competitiveness proves itself by...... forming firms capable of expanding internationally. At the level of subsidiaries as providing institutional back up for these firms' abilities to fight for survival and growth within the frame of rivalling subsidiaries of the MNC. The article discusses at these two levels the comparative institutional...

  1. Competitive Intelligence HF Czechforge

    OpenAIRE

    Nejtek, Petr

    2012-01-01

    This diploma thesis focuses on options of Competitive Intelligence solutions in small and medium enterprises. Applied part is conducted in a medium sized manufacturing company. Theoretical part of this thesis introduces areas of Competitive Intelligence and Business Intelligence, basic technological overview and illustrates Competitive Intelligence cycle description. In Czech republic, majority of companies are in a form of a small or medium enterprise, therefore theoretical definition is pro...

  2. Salary cuts and competitiveness

    OpenAIRE

    Haliassos, Michael

    2013-01-01

    There is a prevalent view outside Greece that promotion of competitiveness is tantamount with price reductions for Greek goods and services. Massive horizontal salary cuts appear, at first, to promote competitiveness by reducing unit labor costs and to reduce fiscal deficits by reducing the wage bill of the public sector. Upon closer look, however, horizontal salary cuts have been much greater than needed for Greek competitiveness, providing an alibi vis a vis the Troika for reforms that are ...

  3. Ireland's Competitiveness Performance 2013

    OpenAIRE

    2013-01-01

    Ireland's Competitiveness Performance assesses Ireland's international competitiveness in relation to our key competitors across more than forty competitiveness indicators in the areas of costs, productivity and innovation, labour market and skills, investment and infrastructure, the business environment and quality of life and sustainability. It provides an assessment of our strengths and our weakness and will assist policymakers in determining the policies needed to ensure Ireland is a more...

  4. COMPETITIVENESS OF SMES

    OpenAIRE

    Sebastian Ion CEPTUREANU

    2015-01-01

    The main reason for addressing competitiveness at SMEs level is that, ultimately, the meso or macro level competitiveness is generated at the enterprises level, the main actors of economic life. It is one of the most used levels of analysis in the literature, due to the special interest shown by companies in their competitive assessment of the situation by referring to direct competitors, using tools that easily lends itself to comparisons between companies (benchmarking is one of the most us...

  5. The Competitive Perception

    OpenAIRE

    Lima, João Tiago

    2012-01-01

    This paper aims to define what competitive perception is. Using Dufrenne’s phenomenological analysis of the art spectator’s experience, namely the concept of aesthetic perception, I will claim that it is useful to apply this phenomenological approach to the experience of watching sport events. I will argue that the concepts of uncertainty and auto teleology, being two main features in sport competition, are helpful to define competitive perception.

  6. Competitive versus comparative advantage

    OpenAIRE

    J. Peter Neary

    2002-01-01

    I explore the interactions between comparative, competitive and absolute advantage in a two-country model of oligopoly in general equilibrium. Comparative advantage always determines the direction of trade, but both competitive and absolute advantage affect resource allocation, trade patterns and trade volumes. Competitive advantage in the sense of more home firms drives foreign firms out of marginal sectors but also makes some marginal home sectors uncompetitive. Absolute advantage in the se...

  7. Competitive versus Comparative Advantage

    OpenAIRE

    Neary, J. Peter

    2002-01-01

    I explore the interactions between comparative, competitive and absolute advantage in a two-country model of oligopoly in general equilibrium. Comparative advantage always determines the direction of trade, but both competitive and absolute advantage affect resource allocation, trade patterns and trade volumes. Competitive advantage in the sense of more home firms drives foreign firms out of marginal sectors but also makes some marginal home sectors uncompetitive. Absolute advantage in the se...

  8. Competition Policy in Mexico

    OpenAIRE

    Ernesto Estrada Gonzalez

    2008-01-01

    The CFC faces significant challenges from cartel activity, prevailing regulatory restrictions on competition, and exclusionary practices undertaken by some of the most powerful corporations in Mexico.

  9. Intramural Gymnastics Competition.

    Science.gov (United States)

    Cornelius, William L.

    1981-01-01

    An intramural gymnastic competition, if properly organized, can foster student and community interest in gymnastics. Aspects of organization and essential preplanning include: directing, judging, scoring, and managing. (JN)

  10. Mallard blue: a high-affinity selective heparin sensor that operates in highly competitive media.

    Science.gov (United States)

    Bromfield, Stephen M; Barnard, Anna; Posocco, Paola; Fermeglia, Maurizio; Pricl, Sabrina; Smith, David K

    2013-02-27

    We report the simple synthesis and full investigation of a novel heparin binding dye, mallard blue, an arginine-functionalized thionine. This dye binds heparin in highly competitive media, including water with high levels of competitive electrolyte, buffered aqueous solution and human serum. The dye reports on heparin levels by a significant change in its UV-vis spectroscopic profile. Molecular dynamics modeling provides detailed insight into the binding mode. Heparin binding is shown to be selective over other glycosaminoglycans, such as hyaluronic acid and chondroitin sulfate. Importantly, we demonstrate that, in the most competitive conditions, mallard blue outperforms standard dyes used for heparin sensing such as azure A. PMID:23406254

  11. Shooting Sports Competition

    OpenAIRE

    Fisher, Sandra

    2015-01-01

    This year for the first time Congress is introducing an actual shooting competition in Rifle and Archery. An introduction and firing the first shots workshop will be conducted with all participants to begin the day and then break out to disciplines for the competition. There will also be a general knowledge/safety test that will count toward the final scores of participants.

  12. Competition Policy and Innovation

    DEFF Research Database (Denmark)

    Møllgaard, Peter; Lorentzen, Jo

    2005-01-01

    topic. We move on to discuss the organisation of industriesin a dynamic context and draw out consequences for competition policy. We concludewith an outlook on the underlying tensions between technology alliances, competitionpolicy, and industrial policy.JEL codes: L4, L5, O31Keywords: Competition...

  13. The competitive challenge

    International Nuclear Information System (INIS)

    This article examines the strategies necessary to succeed in the increasingly competitive independent power industry. The topics of the article include the factors encouraging mergers, acquisitions, and joint ventures, the availability of financing, changes in the market, regulatory climate changes, competition and power planning, Not In My Back Yard and project siting, and the road ahead

  14. Competitiveness, Technology and Skills.

    Science.gov (United States)

    Lall, Sanjaya

    This document examines competitiveness in the developing world. Chapters 1 through 3, which are largely conceptual, examine the following topics: the concept of competitiveness and why it is important; market-stimulating technology policies in developing countries, and the relationship between import liberalization and industrial performance.…

  15. Short run pricing in competitive electricity markets

    International Nuclear Information System (INIS)

    In response to the need for more responsive, competitive and decentralized pricing strategies forced upon the industry by deregulation, this study reviewed the type of electricity pricing required to coordinate a competitive wholesale electricity market over time periods typically of the order of one hour. It was found that nodal spot pricing can provide a straight-forward mechanism for providing the correct signals to market participants, while reflecting the costs and complexities of transmission network operation. Provided that all binding constraints are represented in the pricing model, and assuming that they are used in conjunction with long term contracts and capacity rights, such pricing can potentially deliver most of the benefits promised by perfect coordination, while allowing competition to flourish. 4 refs

  16. Exporting Culture: a Requirement for Competitive Internationalization*

    OpenAIRE

    Jaime H. Sierra G.

    2005-01-01

    his paper proposes a concept of “culture for internationalization” and “exporting culture” –a highly relevant concept for developing countries’ firms that are likely to follow a gradual internationalization process– based on the strong relationship binding the concept proposed to strategy and systemic competitiveness. These three items are paramount to Understand the conditions underlying internationalization as it is characterized by particular traits that make it a key alternative fo...

  17. Crop–weed competition

    DEFF Research Database (Denmark)

    Gallandt, Eric R.; Weiner, Jacob

    2015-01-01

    importantly, weed density and time of emergence relative to the crop. Practices that (1) reduce the density of weeds, (2) maximise occupation of space or uptake of resources by the crop or (3) establish an early-season size advantage of the crop over the weeds will minimise the competitive effects of weeds on...... early-season competitive advantage to the crop and (3) maximising resource capture by the crop using competitive species, competitive cultivars, high sowing densities, optimal spatial arrangement, intercropping complimentary species or transplanting.......Competition from weeds is the most important of all biological factors that reduce agricultural crop yield. This occurs primarily because weeds use resources that would otherwise be available to the crop. The magnitude of yield loss is affected by numerous agronomic and environmental factors, most...

  18. Competition, Ownership and Productivity

    DEFF Research Database (Denmark)

    Baghdasaryan, Delia; la Cour, Lisbeth

    2013-01-01

    Theoretical results support two concurrent views regarding the mediating role that ownership structure might play on the effect of competition on firm performance. According to one stream of literature, competition has a high, positive impact in companies that have an effective ownership structure....... On the contrary, inferences based on the x-inefficiency literature suggest the highest positive effect will be experienced by companies with inappropriate ownership structure. Our empirical analysis on a panel of Czech firms shows that the former view is supported if import competition is high...

  19. Gaining Relational Competitive Advantages

    DEFF Research Database (Denmark)

    Hu, Yimei; Zhang, Si; Li, Jizhen;

    2015-01-01

    Establishing strategic technological partnerships (STPs) with foreign partners is an increasingly studied topic within the innovation management literature. Partnering firms can jointly create sources of relational competitive advantage. Chinese firms often lack research and development (R......&D) capabilities but are increasingly becoming preferred technological partners for transnational corporations. We investigate an STP between a Scandinavian and a Chinese firm and try to explore how to gain relational competitive advantage by focusing on its two essential stages: relational rent generation and...... appropriation. Based on an explorative case study, we develop a conceptual framework that consists of process, organizational alliance factors, and coordination modes that we propose lead to relational competitive advantage....

  20. DMEPOS Competitive Bidding

    Data.gov (United States)

    U.S. Department of Health & Human Services — The DMEPOS Competitive Bidding Program was mandated by Congress through the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA). The...

  1. COMPETITION AS MARKET MECHANISM

    Directory of Open Access Journals (Sweden)

    N. Ya. Kazhuro

    2015-01-01

    Full Text Available The essence of a competition as an objective law for development of the commodities production based on private ownership of the means of production and commodity exchange has been revealed in the paper. The paper presents an economic basis of market economy (private ownership which generates a corresponding production objective. Such purpose is a maximization of profit and a minimization of market subject expenses. Therefore, a struggle for the most favourable conditions on commodity production and sales is inevitable in such situation. The struggle is considered in the community with developed market economy as a competition.The competition is regarded not as an exogenic factor exerting its influence on market economic system from the outside, but as an objective phenomenon which is inherent to management market system in itself. Such treatment is substantiated by economic disintegration of individual commodity producers. Being an important engine of market economy, the competition does not establish its laws, and its role is to be an executive of data which are internally inherent in commodity production laws and firstly it concerns a profit maximization law which defines a purpose and guiding motif of economic entities in the given economy.The competition plays a contradictory role under conditions of market economy. On the one hand, it makes manufacturers constantly to aspire to expense reduction for the sake of profit increase. This has resulted in labour productivity increase, production cost decrease and a company receives an opportunity to reduce retail price for its products. Consequently, the competition acts as a potential factor for lowering of prices while increasing production efficiency. On the other hand, sellers have more freedom in price fixing under conditions of imperfect competition as they sell their products under the conditions of a monopolistic competition or an oligopoly. This is the main weakest point of the market

  2. Competitiveness: Sector Strategy (2003)

    OpenAIRE

    Inter-American Development Bank (IDB)

    2003-01-01

    The Bank's Competitiveness Strategy (GN-2243-1) establishes a framework to assist member countries to make improvements in their economic and institutional environments in order to promote the sustainable development of productive economic activities and increase productivity. Bank Group activities to support improvements in competitiveness will aim to achieve the following: A) The efficient mobilization of financial and capital resources in order to increase the access of firms to financial ...

  3. FameLab competition

    CERN Multimedia

    2011-01-01

    Are you 18 to 35 years old and studying or working in science in Switzerland? Are you passionate about your job and keen on exciting public imagination with a vision of the 21st century of science? Then this competition is for you!   For more information, check out http://www.famelab.ch/ or http://famelab.org/ or write to info@famelab.ch. Read more about the Famelab competition in this Bulletin article.  

  4. REGIONAL COMPETITIVENESS, CONCEPTUAL ELEMENTS

    OpenAIRE

    Florina Popa

    2016-01-01

    In a general sense, competitiveness is conveyed as the ability of a nation to lay the foundations and ensure an economic, social and political environment capable of sustaining the creation of added value, enabling the positioning of a country within global economy, from the perspective of comparing the performances obtained and the growth potential over time. The paper highlights the importance of increasing competitiveness of regional economy and the perspectives for their development. Ther...

  5. RECONSIDERING COMPETITIVE ADVANTAGES

    OpenAIRE

    Valentina Zaharia; Mirela Dogaru

    2011-01-01

    Development of the competitive advantage involves a considerable effort from any organization. In particular, those organizations involved in a strong competitive market require the development of strategies to allocate long-term strategic marketing resources, efficiently and with easily quantifiable results. Faced with a multitude of phenomena and processes sometimes contradictory on different markets of consumption, contemporarily marketing has the mission to develop as creative...

  6. Remittances and competitiveness

    OpenAIRE

    Bayangos, V.B.; Jansen, K.

    2010-01-01

    The paper looks at the impact of workers' remittances on the competitiveness of the receiving economy. It extends existing research that concentrated on the exchange rate effects of remittances, the so-called Dutch disease effect, by adding labour market effects. The results show that the labour market effects of emigration and remittances have a significant impact on competitiveness that goes beyond the traditional exchange rate effect.

  7. Annual Competitiveness Report 2010

    OpenAIRE

    2010-01-01

    Each year the NCC publishes a two-volume Annual Competitiveness Report. Volume One, Benchmarking Ireland's Performance, analyses Ireland's overall competitiveness performance across 135 statistical indicators including education and skills availability, innovation, R&D, regulation, taxation, costs and a variety of other factors that determine Ireland's ability to compete in world markets. Ireland's performance is benchmarked against 18 other economies and the OECD and EU averages. Volume T...

  8. Takeover Defenses and Competition

    OpenAIRE

    Martijn Cremers; Vinay Nair; Urs Peyer

    2007-01-01

    This paper studies the interaction between takeover defenses and product market competition. We find that firms in more competitive industries have more takeover defenses. This is the opposite result from what one would expect if takeover defenses always constitute an inefficient outcome that increases agency costs and managerial entrenchment. A novel explantion is provided by considering the nature of the relationship between the firm and the product (or labor) market. For firms in industrie...

  9. World competitiveness and agriculture

    Directory of Open Access Journals (Sweden)

    J. van Zyl

    1997-07-01

    Full Text Available Against the background of a changing environment in which market factors and greater world trade and competitiveness are increasingly becoming the only criteria for success, a framework for the analysis of world competitiveness is initially developed. This is followed by a discussion on the growth of productivity in agriculture, as well as an exposition of the role of agricultural research. Thirdly, price factors and the terms of trade are discussed, followed by a summary of policy implications.

  10. Competitive Cross-Subsidization

    OpenAIRE

    Chen, Zhijun; Rey, Patrick

    2013-01-01

    This paper analyzes competitive pricing policies by multiproduct firms facing heterogeneous buying patterns. We show that cross-subsidization arises when firms have comparative advantages on different products but are equally efficient overall: Firms earn a profit from multi-stop shoppers by charging positive margins on their strong products but, as price competition for one-stop shoppers drives total margins down to zero, they price weaker products below cost. Banning below-cost pricing lead...

  11. SUSTAINING COMPETITIVE ADVANTAGE

    OpenAIRE

    Mohd Noor, Nurulainy

    2007-01-01

    E.ON entrepreneurship has long been recognised as a potentially viable means for promoting and sustaining corporate competitiveness. Scholl Hammer (1982), Miller (1983), Guth and Ginsberg (1990), Nam and Slevin (1993), and Lumpkin and Dess (1996), for example, have all noted that corporate entrepreneurship can be used to improve competitive positioning and transform corporations, their markets, and industries as opportunities for clue-creating innovation are developed and exploited. However, ...

  12. Competition in energy

    International Nuclear Information System (INIS)

    With changes occurring within both the gas and electricity industries and both sectors undergoing simultaneous reforms at the State and national levels it is timely to look at some major aspects of the energy-reform processes in Australia and to attempt to offer some perspectives from the viewpoint of an industry user of energy. From an industry user's viewpoint there is quantifiable evidence that competition in the energy sector will deliver major economic benefits to industry and the nation. The reform process currently in train will increase Australia's international competitiveness. Commonwealth-State collaboration is useful on economic issues which require a national consistent approach. Many significant and complex arrangement apply to the gas and electricity sectors which add to the complexity of the respective reform processes. More competitive arrangements are therefore required more quickly at several stages of the gas-sector reform process, such as in the commercialization of government utilities, resolving the issue of third-party transmission pricing, and the removal of State governments' impediments to competitive trading. The Hilmer Report on National Competition Policy will help deal with some difficult structural and transitional issues, e.g. third-party access, competitive structures, regulatory regimes, and a consistent national approach.(author). 1 fig., 1 photo

  13. Reflections on Competition, Competition Regulation and the Current Crises

    DEFF Research Database (Denmark)

    Buch-Hansen, Hubert; Wigger, Angela

    2013-01-01

    competition came to enjoy such an exalted status in Europe and then challenges conventional wisdom by bringing into focus the downsides of competition. It argues that excessive competition and neoliberal competition regulation have contributed to intensify the economic, political, social and environmental...

  14. The Issues of Competitiveness. Romania's Competitive Positioning in Global Context

    OpenAIRE

    KARDOS Mihaela

    2010-01-01

    The concept of competitiveness has always been of interest in economic literature, presented under various definitions and aspects, from determinants of competitiveness at microeconomic level to the issues regarding countries' competitive performance in global environment. Competitiveness is approached from different perspectives, such as productivity, technological innovation, capital investment, structural policies, education and training, technological progress, macroeconomic stability, go...

  15. Trade and Competition Policies in Imperfectly Competitive Markets

    OpenAIRE

    Buccella, Domenico

    2008-01-01

    This work analyzes the difference between trade policy and competition policy for prices, wages, employment and national welfare when both product and labor markets are imperfectly competitive. Trade and competition policies have different impact on the domestic labor market when it is unionized. While competitive policies increase union welfare, imports from a foreign country reduce it. Competition policy in the presence of national labor unions does not reduce labor market distortions, whil...

  16. Competitively tight graphs

    CERN Document Server

    Kim, Suh-Ryung; Park, Boram; Sano, Yoshio

    2011-01-01

    The competition graph of a digraph $D$ is a (simple undirected) graph which has the same vertex set as $D$ and has an edge between $x$ and $y$ if and only if there exists a vertex $v$ in $D$ such that $(x,v)$ and $(y,v)$ are arcs of $D$. For any graph $G$, $G$ together with sufficiently many isolated vertices is the competition graph of some acyclic digraph. The competition number $k(G)$ of $G$ is the smallest number of such isolated vertices. In general, it is hard to compute the competition number $k(G)$ for a graph $G$ and it has been one of the important research problems in the study of competition graphs. Opsut~[1982] suggested that the edge clique cover number $\\theta_E(G)$ should be closely related to $k(G)$ by showing $\\theta_E(G)-|V(G)|+2 \\leq k(G) \\leq \\theta_E(G)$. In this note, we study on these inequalities. We first show that for any positive integer $m$ satisfying $2 \\leq m \\leq |V(G)|$, there is a graph $G$ satisfying $k(G)=\\theta_E(G)-|V(G)|+m$ and characterize a graph $G$ satisfying $k(G)=\\...

  17. Political Failures and Intergovernmental Competition

    Directory of Open Access Journals (Sweden)

    Jean Hindriks

    2012-01-01

    Full Text Available In normative public economics, intergovernmental competition is usually viewed as harmful. Although empirical support for this position does not abound, market integration has intensified competition among developed countries. In this paper we argue that when assessing welfare effects of intergovernmental competition for various forms of political failures (the public choice critique, the outcome is ambiguous and competition can be welfare improving.

  18. Gender and Competition in Adolescence

    DEFF Research Database (Denmark)

    Dreber, Anna; Essen, Emma von; Ranehill, Eva

    2013-01-01

    We look at gender differences among adolescents in Sweden in preferences for competition, altruism and risk. For competitiveness, we explore two different tasks that differ in associated stereotypes. We find no gender difference in competitiveness when comparing performance under competition to...

  19. Price competition in procurement

    International Nuclear Information System (INIS)

    When creating a private market to provide a public good, government agencies can influence the market's competitive characteristics. Markets have predictable, but often counterintuitive, behaviors. To succeed in applying available controls, and thereby reduce future costs, agencies must understand the behavior of the market. A model has been constructed to examine some issues in establishing competition for a structure in which there are economies of scale and government is obligated to purchase a fixed total quantity of a good. This model is used to demonstrate a way to estimate the cost savings from several alternative plans for a buyer exploring competitive procurement. The results are not and cannot be accurate for budgeting purposes; rather, they indicate the approximate magnitude of changes in cost that would be associated with changes in the market structure within which procurement occurs

  20. The power of competition

    International Nuclear Information System (INIS)

    The change-over from regulated monopolies to a non-regulated competitive market in the electric utility industry was discussed in terms of marketing and survival strategies for utilities it the newly competitive marketplace. The impact of low natural gas prices was prominently discussed as a danger to hydroelectricity generators because high efficiency turbine generators that are now available. Surplus power capacity in both the Canadian and US markets were discussed. The effects of independent power producers selling electricity wholesale to private utilities was also debated on account of its potential to change the role of the electric utility. The situation of the Bonneville Power Association (BPA), a self-financed government agency, as owner of 15 000 miles of transmission grid that is not allowed to own generation plants, was described. Strategies developed by BPA in an effort to adapt to the competitive market were described and were successful

  1. Business plan competition

    CERN Document Server

    2007-01-01

    "Venture – Companies for tomorrow" is a business plan competition, which supports students and other junior entrepreneurs in developing their business plans. The sixth edition of the competition is now taking place. Venture 2008 highlights: - prize money totalling CHF 150’000; - possibility to optimize business ideas and business plans with the help of experienced coaches: around 200 coaches are available, with a wide range of backgrounds, entrepreneurs as well as venture capitalists; -\tpossibility to present business ideas and business plans to potential investors ("Investor Days" - 17 January and 7 May); - active involvement in the start-up community; -\tcontribution to potential independence. The competition consists of two phases: Phase I, Business idea, Deadline for submission of business idea: 5 December 2007 (online at http://www.venture.ch). Award Ceremony: 17 January 2008 Phase II, Business plan Deadline for submission of business plan: 2 April 2008 (online at...

  2. Price competition in procurement

    Energy Technology Data Exchange (ETDEWEB)

    Keisler, J.M.; Buehring, W.A.

    1996-07-01

    When creating a private market to provide a public good, government agencies can influence the market`s competitive characteristics. Markets have predictable, but often counterintuitive, behaviors. To succeed in applying available controls, and thereby reduce future costs, agencies must understand the behavior of the market. A model has been constructed to examine some issues in establishing competition for a structure in which there are economies of scale and government is obligated to purchase a fixed total quantity of a good. This model is used to demonstrate a way to estimate the cost savings from several alternative plans for a buyer exploring competitive procurement. The results are not and cannot be accurate for budgeting purposes; rather, they indicate the approximate magnitude of changes in cost that would be associated with changes in the market structure within which procurement occurs.

  3. COMPETITIVENESS THROUGH ENVIRONMENTAL HEALTH

    Directory of Open Access Journals (Sweden)

    Dinu Cristina

    2010-12-01

    Full Text Available This millennium, confronted with a globalization of means leading as fast as possible at certain pursued aims, highlights the importance of competitiveness from the perspective of the continuous fight against limitation of resources. In this context, the machine of life evolution and economy has got an engine named competitiveness. The rules of circulation should focus on all livings to whom, from the perspective of survival and natural, human and social life accomplishment, the well- known concept of health may be attached. At the same time, competitiveness through environment health should try to reach the convergent performances which means that any form of superior knowledge and experience should always take into consideration environment health.

  4. Competitive binding of antagonistic peptides fine-tunes stomatal patterning

    OpenAIRE

    Lee, Jin Suk; Hnilova, Marketa; Maes, Michal; Lin, Ya-Chen Lisa; Putarjunan, Aarthi; Han, Soon-Ki; Avila, Julian; U.Torii, Keiko

    2015-01-01

    During development, cells interpret complex, often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues including a family of secreted peptides, EPIDERMAL PATTERNING FACTORS (EPFs). How these signaling peptides orchestrate pattern formation at a molecular level remains unclear. Here we report that Stomagen/EPF-LIKE9 peptide, which promotes stomatal development, requires ERECTA (ER)-family ...

  5. Utility competition and residential customers

    Energy Technology Data Exchange (ETDEWEB)

    Studness, C.M.

    1994-11-01

    Residential customers have found themselves either ignored or ill-used by the major participants in the struggle over utility competition. No group is seeking to secure them the benefits of competition, and those who oppose competition have curried their favor by conjuring up misleading horror stories about how competition would harm them. Yet residential customers ultimately stand to gain as much from competition as larger customers.

  6. Portfolio competitions and rationality

    Czech Academy of Sciences Publication Activity Database

    Kuběna, Aleš Antonín; Šmíd, Martin

    Jihlava: College of Polytechnics Jihlava, 2013 - (Vojáčková, H.) ISBN 978-80-87035-76-4. [International Conference on Mathematical Methods in Economics 2013 /31./. Jihlava (CZ), 11.09.2013-13.09.2013] R&D Projects: GA ČR GA402/09/0965 Institutional support: RVO:67985556 Keywords : portfolio competition * game theory * behavioural finance Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2013/E/kubena-portfolio competitions and rationality.pdf

  7. Competition Fosters Trust

    DEFF Research Database (Denmark)

    Huck, Steffen; Ruchala, Gabriele K.; Tyran, Jean-Robert

    We study the effects of reputation and competition in a stylized market for experience goods. If interaction is anonymous, such markets perform poorly: sellers are not trustworthy, and buyers do not trust sellers. If sellers are identifiable and can, hence, build a reputation, efficiency quadruples...... but is still at only a third of the first best. Adding more information by granting buyers access to all sellers’ complete history has, somewhat surprisingly, no effect. On the other hand, we find that competition, coupled with some minimal information, eliminates the trust problem almost completely...

  8. Joseph Schumpeter on Competition

    OpenAIRE

    Thomas McCraw

    2008-01-01

    The following documents illustrate the relevance of Schumpeter’s thought to competition policy. Part I is an introduction to Schumpeter’s ideas; Part II a series of excerpts from his book, Capitalism, Socialism and Democracy ; Part III a 1951 critique of his stance toward antitrust by the economist Edward S. Mason; and Part IV an evaluation of the current use of Schumpeter’s theories in discussions of competition policy.

  9. Demography and language competition.

    Science.gov (United States)

    Kandler, Anne

    2009-04-01

    Attempts to describe language competition and extinction in a mathematical way have enjoyed increased popularity recently. In this paper I review recent modeling approaches and, based on these findings, propose a model of reaction-diffusion type. I analyze the dynamics of interactions of a population with two monolingual groups and a group that is bilingual in these two languages. The results show that demographic factors, such as population growth or population dispersal, play an important role in the competition dynamic. Furthermore, I consider the impact of two strategies for language maintenance: adjusting the status of the endangered language and adjusting the availability of monolingual and bilingual educational resources. PMID:19943743

  10. Competition and social cohesion

    OpenAIRE

    Mario Libertini

    2014-01-01

    "Competition" and "social cohesion" are both protected by E.U. and Italian laws. The author moves from the analysis of the meaning of these two concepts, in order to reflect on their compatibility and the way to conciliate them. The central problem - in the opinion of the Author - is to abandon the myth of spontaneous markets' order and to rebuild a political order able to maintain and support, as far as possible, the competitive market economy, but also to govern economic processes in critic...

  11. Business Ideas Competition

    CERN Multimedia

    2003-01-01

    Business Ideas Competition "The Rainbow Seed Fund is a UK fund, which provides finance to support the commercialization of good ideas founded on scientific research; it is for the benefit of the UK industry in particular. To encourage ideas from CERN the Rainbow Seed Fund is running a business ideas competition.The winner of this competition will receive an immediate cash prize of GBP £1,000. In addition the Rainbow Seed Fund may well provide finance for market research, for protection of Intellectual Property Rights (IPR) and for prototyping to take the idea forward. Further awards of GBP £750 will be made for ideas which gain investment from the Fund.Candidates will only be required to prepare a 2-4-page summary of their business idea, and not a full business plan. Full details and an entry form are available at www.rainbowseedfund.com ." ALL Members of the Personnel seeking participation in the business ideas competition are asked to submit their ideas via the CERN TT Unit (Jean-Marie.Le Goff@cern.ch) th...

  12. Growing Competition for Libraries.

    Science.gov (United States)

    Gibbons, Susan

    2001-01-01

    Describes the Questia subscription-based online academic digital books library. Highlights include weaknesses of the collection; what college students want from a library; importance of marketing; competition for traditional academic libraries that may help improve library services; and the ability of Questia to overcome barriers and…

  13. Coase Competition and Compensation

    OpenAIRE

    Hal Varian

    1994-01-01

    I show that the Pigovian solution to a simple externalities problem and a particular Coasian solution can be viewed as competitive equilibria from different initial endowments. I also describe the ``compensation mechanism,'' a mechanism that implements either the Coasian or Pigovian solution as the outcome of an economically natural bargaining game.

  14. Competitiveness Index 1990.

    Science.gov (United States)

    Council on Competitiveness, Washington, DC.

    The United States' economic performance in the world economy is compared with that of Canada, France, Germany, Italy, Japan, and the United Kingdom (the Summit 7 countries). Competitiveness is assessed by four economic indicators: standard of living, trade, manufacturing productivity, and investment. The United States continues to outinvest the…

  15. Explaining competitive reaction effects

    NARCIS (Netherlands)

    Leeflang, P.S.H.; Wittink, D.R.

    2001-01-01

    Changes in promotional expenditure decisions for a brand, as in other marketing decisions, should be based on the expected impact on purchase and consumption behavior as well as on the likely reactions by competitors. Purchase behavior may be predicted from estimated demand functions. Competitive re

  16. Competition: Some behavioral issues

    OpenAIRE

    Schmitt, David R.

    1986-01-01

    Conclusions drawn from research in the social sciences comparing the quality or quantity of performance under cooperation and competiton stress the advantages of cooperation. This generalization may be premature, however, because of the paucity of experimental analyses investigating variations in competitive conditions. Neglected in particular have been variables that affect reinforcement conditions among competitors. These include performance differences, the basis of reinforcement, reinforc...

  17. Mediterranean Way of Competitiveness

    Directory of Open Access Journals (Sweden)

    Art Kovacic

    2010-12-01

    Full Text Available The Mediterranean area have a special concept of competitiveness topic. Normally is that region not so industrial and knowledge based oriented as a North Europe.That countries can't reach the same development level as the north one. Lisbon's and Goethenburg's strategies create the main framework of development programme. Mediterranean programme is such a case. European internal market has forced the EU countries to increase competitiveness. The economic prosperity of countries is associated with their ability to generate or attract economic activities which are able to increase income by performing well on themarket. Financial crisis in the EU has changed the look on the competitiveness research. Economy in the main countries has to find way of recovery. Former giants of the financial world have found themselves suddenly facing bankruptcy.Inevitably, the crisis is also having an effect on households and businesses - economic growth has slowed sharply and in some EU countries unemployment has begun to increase for the first time in several years. Form that perspective we have to find the right solution of European competitiveness.

  18. Effects of ATP on calcium binding to synaptic plasma membrane

    International Nuclear Information System (INIS)

    The release of labeled norepinephrine from preloaded synaptosomes requires the presence of potassium and calcium. ATP-dependent binding of calcium to synaptic plasma membranes (SPM) may provide a means of maintaining the cation in a readily available pool for the triggering of transmitter release. A high Ca-binding capacity was demonstrated in SPM. The Km for calcium is 5.5 X 10(-5) M. The dependence of the system on the gamma phosphate of ATP was demonstrated by an increase in Ca-binding with increasing ATP concentration and by competitive inhibition of binding by ADP and AMP. Magnesium is also required for ATP-dependent Ca-binding. The optimum pH for the Ca binding was 7.0. Pretreatment of SPM with phospholipase A2 lowered the binding capacity. Sulfhydryl groups are also critical for ATP-dependent Ca binding to occur. A model for ATP-dependent Ca-binding was proposed

  19. Competitive teacher – competitive graduate of the higher educational institution

    OpenAIRE

    Sokhach Aleksandr Yakovlevich; Plugina Maria Ivanovna

    2015-01-01

    The article discusses issues related to education reform and setting new goals and objectives, and ensuring training of future competitive professionals by enhancing the competence and competitiveness of teachers.

  20. Environmental structure and competitive scoring advantages in team competitions

    Science.gov (United States)

    Merritt, Sears; Clauset, Aaron

    2013-10-01

    In most professional sports, playing field structure is kept neutral so that scoring imbalances may be attributed to differences in team skill. It thus remains unknown what impact environmental heterogeneities can have on scoring dynamics or competitive advantages. Applying a novel generative model of scoring dynamics to roughly 10 million team competitions drawn from an online game, we quantify the relationship between the structure within a competition and its scoring dynamics, while controlling the impact of chance. Despite wide structural variations, we observe a common three-phase pattern in the tempo of events. Tempo and balance are highly predictable from a competition's structural features alone and teams exploit environmental heterogeneities for sustained competitive advantage. Surprisingly, the most balanced competitions are associated with specific environmental heterogeneities, not from equally skilled teams. These results shed new light on the design principles of balanced competition, and illustrate the potential of online game data for investigating social dynamics and competition.

  1. Demolishing the competition: the longitudinal link between competitive video games, competitive gambling, and aggression.

    Science.gov (United States)

    Adachi, Paul J C; Willoughby, Teena

    2013-07-01

    The majority of research on the link between video games and aggression has focused on the violent content in games. In contrast, recent experimental research suggests that it is video game competition, not violence, that has the greatest effect on aggression in the short-term. However, no researchers have examined the long-term relationship between video game competition and aggression. In addition, if competition in video games is a significant reason for the link between video game play and aggression, then other competitive activities, such as competitive gambling, also may predict aggression over time. In the current study, we directly assessed the socialization (competitive video game play and competitive gambling predicts aggression over time) versus selection hypotheses (aggression predicts competitive video game play and competitive gambling over time). Adolescents (N = 1,492, 50.8 % female) were surveyed annually from Grade 9 to Grade 12 about their video game play, gambling, and aggressive behaviors. Greater competitive video game play and competitive gambling predicted higher levels of aggression over time, after controlling for previous levels of aggression, supporting the socialization hypothesis. The selection hypothesis also was supported, as aggression predicted greater competitive video game play and competitive gambling over time, after controlling for previous competitive video game play and competitive gambling. Our findings, taken together with the fact that millions of adolescents play competitive video games every day and that competitive gambling may increase as adolescents transition into adulthood, highlight the need for a greater understanding of the relationship between competition and aggression. PMID:23595418

  2. Competitiveness and climate change

    International Nuclear Information System (INIS)

    The author addresses the relationship between competitiveness and climate policy beyond the issue of emission quota trading, and with taking into account links between different activities. For some sectors, demand may depend on measures undertaken to reduce emissions in the transport and building sectors. According to the author, these interactions could transform the industry on a middle term, more than the required technical changes aimed at the reduction of emissions. After a detailed analysis on these issues, this paper discusses the results of several studies dealing with the relationship between environmental regulation and competitiveness, and with global assessments of carbon leakages. Then, the author discusses the European directive which introduces the Emission Trading Scheme (ETS)

  3. Single elimination competition

    Science.gov (United States)

    Fink, T. M. A.; Coe, J. B.; Ahnert, S. E.

    2008-09-01

    We study a simple model of competition in which each player has a fixed strength: randomly selected pairs of players compete, the stronger one wins and the loser is eliminated. We show that the best indicator of future success is not the number of wins but a player's wealth: the accumulated wealth of all defeated players. We calculate the distributions of strength and wealth for two versions of the problem: in the first, the loser is replaced; in the second, the loser is not. The probability of attaining a given wealth is shown to be path-independent. We illustrate our model with the popular game of conkers and discuss an extension to round-robin sports competition.

  4. Competitive Moves over Time

    DEFF Research Database (Denmark)

    Antero, Michelle; Hedman, Jonas; Henningsson, Stefan

    2014-01-01

    This paper applies the Red Queen theory to explain how organizations utilize various sourcing arrangements in order to compete in an evolutionary arms race where only the strongest competitors will survive. This case study incorporates competition and views sourcing strategies as a means to improve...... its viability to survive in the marketplace. The study begins with a review of sourcing literature to position the Red Queen theory within the sourcing literature. It subsequently applies the framework to a case study of SAP AG to illustrate how sourcing strategies changed over time in response to the...... logic of competition. The case study reveals that (a) organizations are adaptive systems and capable of organizational learning to make strategic changes pertaining to sourcing arrangements; (b) organizations select the terms in which they want to compete by developing certain capabilities within the...

  5. Canadian competitive advantage

    International Nuclear Information System (INIS)

    The evolution of the Canadian petrochemical industry was outlined, emphasizing the proximity to feedstocks as the principal advantage enjoyed by the industry over its international competitors. Annual sales statistics for 1995 were provided. Key players in the Canadian petrochemical industry (Nova, Dow, DuPont, Methanex, Esso, Union Carbide, Shell and Celanese), their share of the market and key products were noted. Manufacturing facilities are located primarily in Alberta, southern Ontario and Quebec. The feedstock supply infrastructure, historical and alternative ethane pricing in Canada and the US, the North American market for petrochemicals, the competitiveness of the industry, tax competitiveness among Canadian provinces and the US, the Canada - US unit labour cost ratio, ethylene facility construction costs in Canada relative to the US Gulf Coast, and projected 1997 financial requirements were reviewed. 19 figs

  6. RECONSIDERING COMPETITIVE ADVANTAGES

    Directory of Open Access Journals (Sweden)

    Valentina Zaharia

    2011-12-01

    Full Text Available Development of the competitive advantage involves a considerable effort from any organization. In particular, those organizations involved in a strong competitive market require the development of strategies to allocate long-term strategic marketing resources, efficiently and with easily quantifiable results. Faced with a multitude of phenomena and processes sometimes contradictory on different markets of consumption, contemporarily marketing has the mission to develop as creative as possible the business strategy of the organizations, their capacity of interacting with customers and other categories of audience. Such concepts as strategic positioning, relational marketing, management of the relationship with the consumer, marketing integrated research, a.s.o. are only a few of the tools with the help of which the marketing managers will implement successful operational strategies. All these developments are creating a real new paradigm of Marketing aimed to better explain the new types of complex market relationship in which the 21st Century organization is .

  7. The Literature of Competitive Intelligence.

    Science.gov (United States)

    Walker, Thomas D.

    1994-01-01

    Describes competitive intelligence (CI) literature in terms of its location, quantity, authorship, length, and problems of bibliographic access. Highlights include subject access; competitive intelligence research; espionage and security; monographs; and journals. (21 references) (LRW)

  8. COMPETITIVENESS OF POTENTIAL INDUSTRIAL PRODUCTION

    OpenAIRE

    САБАДИРЬОВА, А.Л.; Одеський державний економічний університет; САЛАВЕЛІС, Д.Є.; Одеський державний економічний університет

    2011-01-01

     In the article the considered tendencies of forming of competitiveness of potential of enterprises industrial, factors of competitiveness of potential of enterprises at processing industry on the terms of modern market environment.

  9. Attention Competition with Advertisement

    OpenAIRE

    Cetin, Uzay; Bingol, Haluk O.

    2012-01-01

    In the new digital age, information is available in large quantities. Since information consumes primarily the attention of its recipients, the scarcity of attention is becoming the main limiting factor. In this study, we investigate the impact of advertisement pressure on a cultural market where consumers have a limited attention capacity. A model of competition for attention is developed and investigated analytically and by simulation. Advertisement is found to be much more effective when a...

  10. Competitiveness through information

    OpenAIRE

    Raluca Daniela RIZEA; Roxana SÂRBU; Elena CONDREA

    2013-01-01

    Intelligence competitiveness has already started to build its road in the company’s long term strategies. Nonetheless, business executives continue to look for ways to apply information technology strategically to their businesses. Using information managers manage to communicate, to convey their knowledge about markets, competitors, products, services and operations. Even if data and information are all over there are few amounts of managers that realize the importance of them to the success...

  11. Securitization and Lending Competition

    OpenAIRE

    Frankel, David M.; Jin, Yu

    2011-01-01

    We study the effects of securitization on interbank lending competition when banks see private signals of local applicants' repayment chances. If banks cannot securitize, the outcome is efficient: they lend to their most creditworthy local applicants. With securitization, banks lend also to remote applicants with strong observables in order to lessen the lemons problem they face in selling their securities. This reliance on observables is inefficient, raises the mean default risk, and may lea...

  12. Competition and Innovation

    OpenAIRE

    Gilbert, Richard J.

    2007-01-01

    The Department of Justice and the Federal Trade Commission have frequently raised innovation concerns as reasons to challenge mergers. This chapter surveys the economic theories of innovation incentives and considers how the theory may inform antitrust analysis for merger investigations and other conduct that involve innovation. Competition can promote innovation by reducing the value of failing to invest in research and development. However, with non-exclusive intellectual property rights...

  13. Competition among mass media

    OpenAIRE

    Kwiek, Maksymilian

    2010-01-01

    This paper investigates how mass media provide information to readers or viewers who have diverse interests. The problem of a mass medium comes from the fact that there is a constraint on how much information can be delivered. It is shown that the mass medium optimally provides information that is somewhat useful to all agents, but not perfect to anybody in particular. This benchmark model is then used to investigate competition among mass media with differentiated products. In the equilibriu...

  14. Energy and Competitiveness

    OpenAIRE

    Bureau, Dominique; Fontagné, Lionel; Martin, Philippe

    2013-01-01

    When energy prices are expected to rise over the next twenty years, it is essential that industrial innovation efforts and the supply of goods and service off erings be directed towards energy-efficient technologies. However, a more significant increase in energy prices in France than in other countries would be detrimental to the short-term competitiveness of French industry. The present Note outlines the terms of the trade-off France has to confront between reserving a significant part of i...

  15. Political Competition and Polarization

    DEFF Research Database (Denmark)

    Schultz, Christian

    This paper considers political competition and the consequences of political polarization when parties are better informed about how the economy functions than voters are. Specifically, parties know the cost producing a public good, voters do not. An incumbent's choice of policy acts like a signal...... for costs before an upcoming election. It is shown that the more polarized the political parties the more distorted the incumbent's policy choice....

  16. Competitive Policy Development

    OpenAIRE

    Hirsch, Alexander V.; Shotts, Kenneth W.

    2015-01-01

    We present a model of policy development in which competing factions have different ideologies, yet agree on certain common objectives. Policy developers can appeal to a decision maker by making productive investments to improve the quality of their proposals. These investments are specific to a given proposal, which means that policy developers can potentially obtain informal agenda power. Competition undermines this agenda power, forcing policy developers to craft policies that are better f...

  17. Thinking About Competitive Balance

    OpenAIRE

    Allen R. Sanderson; John J. Siegfried

    2003-01-01

    Simon Rottenberg long ago noted that the nature of sports is such that competitors must be of approximately equal ability if any are to be financially successful. In recent years, sports commentators and fans, Major League Baseball itself, and even some economists have expressed growing concern about the widening disparities among team expenditures and the growing concentrations of postseason contenders and championships. In this article we compare different concepts of competitive balance, r...

  18. Competition and Car Longevity

    OpenAIRE

    Macauley, Molly; Hamilton, Bruce

    1998-01-01

    We examine determinants of the nearly 30 percent increase in the average age of domestically produced, registered automobiles since the mid-1960s. We find that very little of the increase in car longevity is attributable to improvements in the inherent durability of cars. Rather, we find that the temporal pattern of longevity improvement is highly correlated with the level of market concentration in the auto industry. In particular, we argue that the arrival of competition in the industry led...

  19. Competition: the answers

    CERN Multimedia

    Staff Association

    2016-01-01

    The correct answers to the Staff Association Competition are: How many women delegates are there currently in the Staff Council? -14 Who is the current President of the Staff Association? - Alessandro Raimondo Which year was the Nursery School established by the Staff Association at CERN?  -1965 How many CERN clubs are supported by the Staff Association? -44 What is the supreme representative body of the Staff Association ? -The Staff Council   The winners will be informed by email.

  20. Progesterone Binding and Inhibition of Growth in Trichophyton mentagrophytes

    OpenAIRE

    1986-01-01

    Specific binding of [3H]progesterone to cytosol of Trichophyton mentagrophytes was demonstrated. Scatchard analysis of [3H]progesterone binding showed a single class of binding sites with a dissociation constant of 9.5 X 10(-8) [corrected] +/- 2.4 X 10(-8) M (standard deviation) and a maximal binding capacity of 4,979 +/- 3,489 fmol/mg of cytosol protein. Deoxycorticosterone and dihydrotestosterone competitively inhibited binding by 50% at molar ratios of 10:1 and 20:1, respectively. Other st...

  1. Energy and competitiveness

    International Nuclear Information System (INIS)

    Energy efficiency-related programs in two Canadian provinces are reviewed. The Ontario Ministry of Energy has implemented programs to improve industrial energy efficiency in order to contribute to future economic growth. Since 1987, the Industrial Energy Services Program provides energy audits, feasibility analysis grants, and project engineering grants for energy efficiency improvements. Results show that an industrial plant can cut its energy costs by an average of 10% with the proper help. To minimize electricity costs, Ontario Hydro has a demand management program that offers a combination of financial assistance for energy conservation measures, rate incentives, standards and regulation, and fuel substitution. Results in 1992 show 250 MW in saved and shifted load. In Alberta, a TransAlta Utilities program in supply side management has the objective of maximizing the production potential of existing plants. The resulting benefit is improved electric power production efficiency that leads to increased competitiveness. Side benefits include delay of new plant construction, reduced coal consumption, and reduction in greenhouse gas emissions. Finally, Canada's economic competitiveness is reviewed historically and measures to improve this competitiveness are suggested. A new national policy strategy would include gradual elimination of all import tariffs, optimization of natural resources, securing energy availability at prices at or below world levels, and becoming a leader in transportation and communications. 1 fig., 1 tab

  2. APPROACHES ON THE COMPETITIVE INTELLIGENCE

    OpenAIRE

    Ioan PETRIŞOR; Natalia Ana STRĂIN (SILAŞ)

    2013-01-01

    Within this study, we approached the concept of "competitive intelligence" (CI), which we consider a key element for the success of a business, especially in the current period, characterized by numerous economic and financial turbulence. According to Society of Competitive Intelligence (SCIP), competitive intelligence is defined as a method of ethical and moral collection, analysis and dissemination of information regarding the competitive environment, opportunities, vulnerabilities, and int...

  3. The generalized sports competition problem

    OpenAIRE

    Kern, W; Paulusma, D.

    2002-01-01

    Consider a sports competition among various teams playing against each other in pairs (matches) according to a previously determined schedule. At some stage of the competition one may ask whether a particular team still has a (theoretical) chance to win the competition. The computational complexity of this question depends on the way scores are allocated according to the outcome of a match. For competitions with at most $3$ different outcomes of a match the complexity is already known. In pra...

  4. The International SAT Solver Competitions

    OpenAIRE

    Järvisalo, Matti; University of Helsinki; Le Berre, Daniel; University of Artois; Roussel, Olivier; University of Artois; Simon, Laurent; University of Paris-Sud

    2012-01-01

    The International SAT Solver Competition is today an established series of competitive events aiming at objectively evaluating the progress in state-of-the-art procedures for solving Boolean satisfiability (SAT) instances. Over the years, the competitions have significantly contributed to the fast progress in SAT solver technology that has made SAT a practical success story of computer science. This short article provides an overview of the SAT solver competitions.

  5. FEATURES CONCERNING COMPETITIVE PERFORMANCE MEASUREMENT

    OpenAIRE

    Cristina Coculescu

    2008-01-01

    Innovation and competitiveness are the main vectors of social-economic progress of every country. Starting from this general context and considering the particular context wherein Romania is, which strongly impose the growth of economic competitiveness for realize the convergence to EU countries, in this item we propose to put in evidence the kinds of competitive performance measurement. For this, we’ll study from economic development point, competitiveness index contained in Global Competiti...

  6. Measuring institutional competitiveness in Europe

    OpenAIRE

    Huemer, Stefan; Scheubel, Beatrice; Walch, Florian

    2013-01-01

    While there are many methods to measure the competitiveness of an economy, most of these concepts ignore the fact that competitiveness can change because of market processes like wage negotiation but also because of political decision-making. Governments that compete with others for factors of production face the incentive to adjust key policy variables to improve their competitive position. Disentangling market-induced and politics-induced changes in competitiveness is not easy, but strongly...

  7. SMES COMPETITIVENESS AND ENVIRONMENTAL INFLUENCES

    OpenAIRE

    Bibu Nicolae; Popovici Adina; Sala Diana

    2010-01-01

    In the related literature, there are many ways in which company competitiveness can be defined and understood. The purpose of this research is a better understanding of the SMEs competitiveness from the West Region of Romania. This study presents preliminary results of a research focussed on SMEs competitiveness. There are some positive and negative local and national factors which are influencing firms’ competitiveness. This study confirms us our presumptions. The internal and external envir...

  8. Integrated Approach to Competitive Advantage

    OpenAIRE

    Edita Ragelskaja; Renata Korsakienė

    2011-01-01

    Environmental changes and globalization of markets make an impact on intense competition in almost all business sectors. Evolutionary changes influence companies to learn, adequately react, adapt to environmental changes and to change themselves. Such a situation has revealed the problems of competitive advan­tage of industry companies. Therefore the focus to the factors impacting competitive advantage is seen as timely and relevant. The authors of the paper analyze approaches to competitive ...

  9. Managerial Economics and Global Competition

    OpenAIRE

    Silvio M. Brondoni

    2005-01-01

    Global managerial economics tends to emerge in conditions of strong, continuous competitive tension, in contexts that are open and subject to political, social and technological instability. Globalisation and new competition boundaries oblige companies to adopt a new 'market-oriented competitive management philosophy' (market-driven management), in which customer value management predominates. Global managerial economics thus interfaces with numerous competition spaces, all with different lev...

  10. Uniqueness is Important in Competition

    Institute of Scientific and Technical Information of China (English)

    FENG Ai-Xia; XV Xiu-Lian; HE Da-Ren

    2009-01-01

    We propose a quantitative network description on the function of uniqueness in a competition system. Two statistical parameters, competition ability and uniqueness are defined, and their relationship in ordinary cases is analytically discussed. The competition between Chinese regional universities is taken as an example. The empirical investigation results show that the uniqueness of a university is really important in competition. Also,uniqueness is very helpful in the promotion of the university overall quality.

  11. Competition in a Business Network

    DEFF Research Database (Denmark)

    Ellegaard, Chris; Medlin, Christopher J

    Competition and cooperation stabilize and structure business networks. In business research there is little focus on network based competition between firms and on how firms compete to gain network position. We review a range of conceptualizations of competition and cooperation and work towards a...... research and also managerial thinking about network strategy and implementation....

  12. Competitive Intelligence and Social Advantage.

    Science.gov (United States)

    Davenport, Elisabeth; Cronin, Blaise

    1994-01-01

    Presents an overview of issues concerning civilian competitive intelligence (CI). Topics discussed include competitive advantage in academic and research environments; public domain information and libraries; covert and overt competitive intelligence; data diversity; use of the Internet; cooperative intelligence; and implications for library and…

  13. Corporate Social Responsibility and Competitiveness

    OpenAIRE

    tureanu Simona-Luize

    2012-01-01

    Corporate social responsibility helps achieving different social, environmental and economic policy goals, but it can also contribute to competitiveness. This paper concentrates on how CSR could help competitiveness at level of individual enterprises. Moreover the connection between macro-level competitiveness and CSR is presented.

  14. Environmental structure and competitive scoring advantages in team competitions

    CERN Document Server

    Merritt, Sears

    2013-01-01

    In most professional sports, the structure of the environment is kept neutral so that scoring imbalances may be attributed to differences in team skill. It thus remains unknown what impact structural heterogeneities can have on scoring dynamics and producing competitive advantages. Applying a generative model of scoring dynamics to roughly 10 million team competitions drawn from an online game, we quantify the relationship between a competition's structure and its scoring dynamics. Despite wide structural variations, we find the same three-phase pattern in the tempo of events observed in many sports. Tempo and balance are highly predictable from a competition's structural features alone and teams exploit environmental heterogeneities for sustained competitive advantage. The most balanced competitions are associated with specific environmental heterogeneities, not from equally skilled teams. These results shed new light on the principles of balanced competition, and illustrate the potential of online game data...

  15. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    DEFF Research Database (Denmark)

    Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R;

    2013-01-01

    the competitive interaction and high potency. To delineate the binding mechanism, we have solved the crystal structure of the GluN1 ligand-binding domain in complex with TK40 and show that TK40 binds to the orthosteric binding site of the GluN1 subunit with a binding mode that was also predicted by virtual...

  16. Retail electricity competition in Ontario

    International Nuclear Information System (INIS)

    A brief overview of the operation of retail competition in Ontario's electricity market as recommended by the Market Design Committee (MDC) is provided. The mandate of the MDC is to make recommendations on the structure of Ontario's competitive electricity market that is due to begin in the year 2000. The main recommendations regarding the design of the competitive retail market have been included in the MDC's second quarterly report. This paper briefly outlines the MDC's recommendations on: (1) the default supply of electricity in Ontario, (2) retail commodity competition, (3) competition in metering, (4) customer data access, and (5) green marketing

  17. Competition Advocacy: the Italian Experience

    Directory of Open Access Journals (Sweden)

    Salvatore Rebecchini

    2014-07-01

    Full Text Available Competition advocacy is considered, together with enforcement, the core business of an antitrust authority. Broadly speaking there are at least three main tasks regularly performed by most, if not all, antitrust agencies that are amenable to the advocacy function: addressing laws and regulations in order to remove unnecessary impediments to competition; engaging in sector enquiries to understand markets behavior and identify critical issues; explaining the benefits of open competitive markets to the public opinion. This article examines these three main tasks and outlines the challenges for competition agencies, with references to the experience of the Italian Competition Authority (ICA and the initiatives undertaken at international level.

  18. Competition, Corruption and Institutional Design

    OpenAIRE

    Seung Han Yoo

    2014-01-01

    This paper offers a model to study competition and corruption with a principal-agent framework. We provide two key results on the optimal institutional design. First, in quality-only competition, corruption does no harm to the principal, but in quality-price competition, corruption negatively a¢´ects the principal. Second, with no corruption, quality-price competition is a superior institutional setting for the principal compared with quality-only competition when the principal?s net bene?t i...

  19. Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk

    Science.gov (United States)

    BACKGROUND Few accurate data exist on the concentration of vitamin B12 in human milk. Binding of the vitamin to haptocorrin (HC) can interfere with the assay if not removed by pretreatment, and very low values can occur in women with poor B12 status. This study evaluated two competitive enzyme bind...

  20. Competition and confidence

    International Nuclear Information System (INIS)

    After a presentation of the new situation of the energy sector with the opening of European energy markets to competition, the author recalls the role of the French government in the organisation and operation of this market: reliable information and protection of consumers, security of supplies with reasonable gas prices, sound relations and partnerships with producing and transit countries. France agrees with the diagnostic of the European Commission about the necessity to improve the operation of the domestic energy markets but differs with the projects of the Commission on the means to be implemented to ensure transparency, non-discrimination, and efficiency in the operation of these markets. (J.S.)

  1. Competition in Soccer Leagues

    OpenAIRE

    Hansen, Bodil Olai; Tvede, Mich

    2007-01-01

    In the present paper a model of competition between sports clubs in a sports league is presented. Clubs are endowed with initial players but at a cost clubs are able to sell their initial players and buy new players. The results are that: if the quality of players is one-dimensional, then equilibria in pure strategies exist, and; if the quality of players is multi-dimensional, then there need not exist equilibria in pure strategies, but equilibria in mixed strategies exist. Equilibria in mixe...

  2. Competitive Advantage through Innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Maier, Maximilian; Wimschneider, Christine

    2016-01-01

    failure several times. Before the current situation of the company, it remains challenging in the future as well. Hence, the Nespresso story provides interesting space for discussion and learning about what innovation is, how innovation emerges, and under which circumstances innovation can serve as a......Purpose The purpose of this paper is to describe how Nespresso achieved competitive advantage through innovation by changing the rules of the game in its industry. Design/methodology/approach Nespresso was analyzed based on public available secondary data, in combination with related academic...

  3. Competitive Manufacturing Dynamics

    DEFF Research Database (Denmark)

    Rymaszewska, Anna; Christensen, Irene; Karlsson, Christer

    to constantly improve this process in terms of time to volume, according to predefined cost and quality measures. The importance of the success of this process can lead to a significant creation of competitive advantage. This paper addresses the challenges of the manufacturing ramp-up process in the......The increasing complexity of business environments and the pressure for organizations on delivering new products faster while maintaining the superior quality of their products, has forced manufacturing organizations to rethink their operations. Managers responsible for manufacturing ramp-up need...

  4. Safety and competitiveness

    International Nuclear Information System (INIS)

    This file studies if the safety is compatible with the search for competitiveness. As some nuclear operators change into energy multinational, as the energy production is submitted to the law of a de-regulated market, as evolutions are announced on the status of the national electrician, one takes stock of the challenges and the risks of this evolution. If it is important to take into account the good economic performances it is a necessity to watch over these economic performances are not got to the detriment of safety and the continuation of its improvement. (N.C.)

  5. Offshoring and International Competitiveness

    DEFF Research Database (Denmark)

    Ørberg Jensen, Peter D.; Pedersen, Torben

    2012-01-01

    advanced offshoring, exploring what causes firms to offshore some of their more advanced tasks. Our findings indicate that while the lower cost of unskilled, labor-intensive processes is the main driver for firms that offshore less advanced tasks, the offshoring of advanced tasks is part of firms’ strategy...... to achieve international competitiveness through access to cross-border knowledge flows and foreign knowledge resources. Furthermore, offshoring of advanced manufacturing tasks seems to be more widespread and experience-based than the offshoring of advanced service tasks....

  6. Energy and competition

    International Nuclear Information System (INIS)

    The members of the Enquete Commission ''Future Energy Policy'' of the German Bundestag are introduced as well as the list of participants from industry and other organizations in the public heaving on 18 th December 1981. Then the catalogue of questions of the Enquete Commission is presented. The written answers of the 11 representatives of industry form the main part of the report. In the following the minutes of the public hearing of the Enquete Commission 'Future Energy Policy' of the German Bundestag on Friday, 18 th December 1981 on the topic of 'The Competitiveness of German economy in various energy supply structures' is presented. (UA)

  7. Rowing competitions and perspective

    Science.gov (United States)

    Flores, Alfinio; Bernhardt, Stephen A.; Shipman, Henry L.

    2015-02-01

    This paper is about integrating the use of graphing technology (specifically, GeoGebra) with principles of motion, principles of perspective, and the concept of vanishing points to model a dynamic event. Students were asked to analyse video images of a rowing competition filmed with a single camera positioned perpendicular to the race. The fixed position of the camera in such races makes it difficult to determine whether a scull closer to the camera is actually overtaking another, more distant scull. The paper illustrates how students in their first year at the university can integrate the use of technology, science, mathematics, and writing to solve a real world problem involving motion.

  8. Attention competition with advertisement

    Science.gov (United States)

    Cetin, Uzay; Bingol, Haluk O.

    2014-09-01

    In the new digital age, information is available in large quantities. Since information consumes primarily the attention of its recipients, the scarcity of attention is becoming the main limiting factor. In this study, we investigate the impact of advertisement pressure on a cultural market where consumers have a limited attention capacity. A model of competition for attention is developed and investigated analytically and by simulation. Advertisement is found to be much more effective when the attention capacity of agents is extremely scarce. We have observed that the market share of the advertised item improves if dummy items are introduced to the market while the strength of the advertisement is kept constant.

  9. Environmental structure and competitive scoring advantages in team competitions

    OpenAIRE

    Sears Merritt; Aaron Clauset

    2013-01-01

    In most professional sports, the structure of the environment is kept neutral so that scoring imbalances may be attributed to differences in team skill. It thus remains unknown what impact structural heterogeneities can have on scoring dynamics and producing competitive advantages. Applying a generative model of scoring dynamics to roughly 10 million team competitions drawn from an online game, we quantify the relationship between a competition's structure and its scoring dynamics. Despite wi...

  10. Competitive Priorities and Competitive Advantage in Jordanian Manufacturing

    OpenAIRE

    2013-01-01

    The purpose of this research was to explore and predict the relationship between the competitive priorities (quality, cost, flexibility and delivery) and the competitive advantage of firms in the Jordanian Industrial Sector. A population of 88 Jordanian manufacturing firms, registered on the Amman Stock Exchange, was targeted using a cross-sectional survey employing a questionnaire method of data collection. The results of the data analysis indicate a significant relationship between competit...

  11. Tax competition: A general review

    Directory of Open Access Journals (Sweden)

    Raičević Božidar B.

    2004-01-01

    Full Text Available Tax competition is increasingly attracting the attention of not only experts Although it is difficult to define precisely, grosso modo, it is actually a competition between states (jurisdictions in attracting capital (investors by tax instruments, especially tax incentives. The first recorded cases of tax competition emerged in 12th century (attracting wool weavers into regions of North Italy-Piemont. Today, tax competition has undreamt-of and very dynamic forms, both territorial and sectored. However, tax competition is accompanied not only by positive but also by rather strong negative effects. Positive effects worth mentioning are the following: 1. control of power, 2. innovations, and 3. incentives. However, negative effects, embodied in "unfair tax competition", provoke a range of unwanted and important distortions in international trade. All of them arise from requirements and wants of tax payers (especially companies to minimize or evade their tax obligations, on the one hand, as well as.

  12. Competitiveness and carbon leakages

    International Nuclear Information System (INIS)

    The authors discuss the implications of the Emission Trading Scheme (ETS) in terms of competitiveness and profitability for companies. As this scheme may induce a risk of 'carbon leakage', equilibrium must be found between usage cost increase due to this scheme and decisions of investments in less carbon-emitting technologies. As the identification of the impacted sectors is at the core of the negotiation about the 'Climate and Energy' package, the authors describe the Commission's proposition which comprises a first stage of identification of the impacted sectors and a second stage to take the results of international negotiations for an international agreement on the post-Copenhagen period. The authors comment the issues and the status of the European negotiations

  13. Product Positioning Under Price Competition

    OpenAIRE

    S. Chan Choi; DeSarbo, Wayne S, et al; Patrick T. Harker

    1990-01-01

    This paper presents a consumer-based methodology for new product pricing and positioning in the face of price competition. The price competition is modelled as a Nash equilibrium for which two complementary approaches are employed: an analytical approach of duopoly provides qualitative insights into the competitive behavior, and a numerical approach of general oligopoly provides quantitative solutions under a wide variety of market scenarios. The optimal product positioning is formulated as a...

  14. Knowledge Resources and Competitive Advantage

    OpenAIRE

    Doris Gomezelj Omerzel; Rune Ellemose Gulev

    2011-01-01

    The paper discusses some definitions of knowledge as a potential source of competitive advantage. It reviews the literature pertaining to the assessment of knowledge assets. According to the resource-based view, which links the competitive advantage of organizations with resources and capabilities that are firm-specific, and difficult to imitate or substitute, a firm’s competitive advantage is built on a set of strategically relevant resources (Barney 1991; Grant 1991; Peteraf 1993). When fir...

  15. Tax Competition through Tax Evasion

    OpenAIRE

    Klaus Beckmann

    2001-01-01

    In the present paper, 1 analyse the competitive behaviour of benevolent governments in the presence of (capital) income tax evasion when information exchange is not possible. My approach is to introduce a cost of evasion function into an otherwise standard tax competition model and to explore three variants of the basic tax competition cum evasion game. Two distinct justifications for tax harmonisation emerge. First, harmonisation of taxation at the source can be supported with the usual spil...

  16. Competition in the Cryptocurrency Market

    OpenAIRE

    Gandal, Neil; Hałaburda, Hanna

    2014-01-01

    We analyze how network effects affect competition in the nascent cryptocurrency market. We do so by examining the changes over time in exchange rate data among cryptocurrencies. Specifically, we look at two aspects: (1) competition among different currencies, and (2) competition among exchanges where those currencies are traded. Our data suggest that the winner-take-all effect is dominant early in the market. During this period, when Bitcoin becomes more valuable against the U.S. dollar, it a...

  17. Sport competitions in Antique Chersoneses.

    OpenAIRE

    Moutiev A.V.; Moutieva I.M.

    2011-01-01

    It is examined the content of physical education in Chersoneses in the ancient period. It is shown the participation of citizens in the Chersoneses competitions at various levels. Stressed the importance of physical culture, sports, sports training, organizing and conducting athletic competitions. Show the direction of physical education of youth, training for local and Panhellenic competitions, military service. The role of the teacher of gymnastics in physical education students in public s...

  18. Competitiveness in the New Economy

    OpenAIRE

    Rouvinen, Petri

    2002-01-01

    This paper devises an e-competitiveness index attempting to measure the ability of a nation to exploit information and communication technology (ICT) to the fullest. Results of the analysis show that Finland is highly specialized in ICT provision, it has good premises to exploit ICT to the fullest, but that it is not amongst the leading users of ICT. – Internet ; ICT ; IT ; new economy ; competitiveness ; e-competitiveness

  19. NATIONAL COMPETITIVENESS - SCENARIOS FOR ROMANIA

    OpenAIRE

    Herciu, Mihaela

    2012-01-01

    Competitiveness remains a continuous concern of nations in any stage of development, from factor based economy to innovation based economy. The present paper aims to emphasize the current level of national competitiveness of Romania, on one hand, and to identify possible ways to improve the current level by building scenarios in order to eliminate the uncertainty, on the other hand. The paper proposes four scenarios for increase GCI (growth competitiveness index) and four scenarios from pessi...

  20. Inside-outside money competition

    OpenAIRE

    Ramon Marimon; Juan Pablo Nicolini; Pedro Teles

    2003-01-01

    We study how competition from privately supplied currency substitutes a¤ects monetary policy. We focus on regimes where monetary policy must be sequentially optimal. We obtain that the workings of competition between currency and currency substitutes depend critically on government objectives. However, the impact inside money competition has on equilibrium outcomes does not. In fact, we show that, in general, it enhances e¢ciency and reduces equilibrium in‡ation rates. Nevertheless, if the su...

  1. Competition Effects of Supermarket Services

    OpenAIRE

    Bonanno, Alessandro; Lopez, Rigoberto A.

    2007-01-01

    This paper investigates the effect of in-store services on retail food prices, supermarket competition, and demand using fluid milk as a case study. It is shown that higher-service supermarkets charge higher milk prices essentially because of an increase in market power due to differentiation of service offering. Results show that different types of services impact milk prices differently, that upscale food-retailers face stronger competition in newer services, and that service competition re...

  2. INNOVATION STRATEGIES AND COMPETITIVE ADVANTAGE

    OpenAIRE

    2013-01-01

    Companies today operate in a very dynamic, uncertain and competitive environment. They compete in "nicety" that are so small but so important. Companies are trying to achieve competitive advantage in order to help them obtain a better and a stable position in the marketplace. The best way for companies to achieve a competitive advantage is through innovation. This paper addresses the meaning of innovation what does innovation present, types of innovation specifically discussing the right way ...

  3. PUBLIC EDUCATION AND ECONOMIC COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Gabriel-Andrei Donici

    2011-09-01

    Full Text Available There is a certain connection between education and economic competitiveness. The relation between these two concepts is easy to intuit. On the medium and long term investments in education generate astrong increase in a country’s level of economic competitiveness. Through education the human capital is formed, and it affects all economic fields. Therefore we can observe that human capital has a decisive influence on the economic competitiveness of a country.

  4. Interference competition and species coexistence.

    OpenAIRE

    Amarasekare, Priyanga

    2002-01-01

    Interference competition is ubiquitous in nature. Yet its effects on resource exploitation remain largely unexplored for species that compete for dynamic resources. Here, I present a model of exploitative and interference competition with explicit resource dynamics. The model incorporates both biotic and abiotic resources. It considers interference competition both in the classical sense (i.e. each species suffers a net reduction in per capita growth rate via interference from, and interferen...

  5. COMPETITIVE ADVANTAGES OF TRADING ENTERPRISES

    OpenAIRE

    Yakimenko, N.; Fedorov, V.

    2014-01-01

    Studied theoretical approaches and principles of classification of competitive advantages, including commercial enterprises. Determined that the possibility of increasing the company's competitiveness is determined by the presence of a sustainable competitive advantage. Сompetitive advantage is determined by the target factors, their structure and proportions, the organization of effective use of factors of enterprise development, the speed of the establishment, improvement and renovation, de...

  6. Competitive Capacity Investment under Uncertainty

    OpenAIRE

    Li, Xishu; Zuidwijk, Rob; Koster, René; Dekker, Rommert

    2016-01-01

    textabstractWe consider a long-term capacity investment problem in a competitive market under demand uncertainty. Two firms move sequentially in the competition and a firm’s capacity decision interacts with the other firm’s current and future capacity. Throughout the investment race, a firm can either choose to plan its investments proactively, taking into account possible responses from the other firm, or decide to respond reactively to the competition. In both cases, the optimal decision at...

  7. Mapping your competitive position.

    Science.gov (United States)

    D'Aveni, Richard A

    2007-11-01

    A price-benefit positioning map helps you see, through your customers' eyes, how your product compares with all its competitors in a market. You can draw such a map quickly and objectively, without having to resort to costly, time-consuming consumer surveys or subjective estimates of the excellence of your product and the shortcomings of all the others. Creating a positioning map involves three steps: First, define your market to include everything your customers might consider to be your product's competitors or substitutes. Second, track the price your customers actually pay (wholesale or retail? bundled or unbundled?) and identify what your customers see as your offering's primary benefit. This is done through regression analysis, determining which of the product's attributes (as described objectively by rating services, government agencies, R&D departments, and the like) explains most of the variance in its price. Third, draw the map by plotting on a graph the position of every product in the market you've selected according to its price and its level of primary benefit, and draw a line that runs through the middle of the points. What you get is a picture of the competitive landscape of your market, where all the products above the line command a price premium owing to some secondary benefit customers value, and all those below the line are positioned to earn market share through lower prices and reduced secondary benefits. Using examples as varied as Harley-Davidson motorcycles, Motorola cell phones, and the New York restaurant market, Tuck professor D'Aveni demonstrates some of the many ways the maps can be used: to locate unoccupied or less-crowded spaces in highly competitive markets, for instance, or to identify opportunities created through changes in the relationship between the primary benefit and prices. The maps even allow companies to anticipate--and counter-- rivals' strategies. R eprint RO711G PMID:18159791

  8. Sport competitions in Antique Chersoneses.

    Directory of Open Access Journals (Sweden)

    Moutiev A.V.

    2011-12-01

    Full Text Available It is examined the content of physical education in Chersoneses in the ancient period. It is shown the participation of citizens in the Chersoneses competitions at various levels. Stressed the importance of physical culture, sports, sports training, organizing and conducting athletic competitions. Show the direction of physical education of youth, training for local and Panhellenic competitions, military service. The role of the teacher of gymnastics in physical education students in public schools. It is noted that the study involved in Chersoneses pedagogical methods and techniques. It is established that the citizens of Chersoneses actively participated in Panhellenic competitions and they became the victors.

  9. BUSINESS COMPETITORS AND COMPETITIVE ADVANTAGE

    Directory of Open Access Journals (Sweden)

    SUCIU TITUS

    2013-08-01

    Full Text Available The paper presents the concept of competition, both from the perspective of the economic sector –where it is characteristic for pure monopole, oligopoly, monopole competition and pure competition, as well asfrom the market’s point of view – where it determines the strategies, objectives, advantages and weaknesses of acompany. The main point of the paper is the criticism of the pure and perfect competition theory. Concluding,the author insists on innovation, especially on the model of open innovation.

  10. The Annual Computer Poker Competition

    OpenAIRE

    Bard, Nolan; University of Alberta; Hawkin, John; Verafin; Rubin, Jonathan; PARC; Zinkevich, Martin; Google

    2013-01-01

    Now entering its eighth year, the Annual Computer Poker Competition (ACPC) is the premier event within the field of computer poker. With both academic and nonacademic competitors from around the world, the competition provides an open and international venue for benchmarking computer poker agents. We describe the competition’s origins and evolution, current events, and winning techniques.

  11. DOE Collegiate Wind Competition (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Jones, J.

    2014-02-01

    This presentation for the January Stakeholder Engagement and Outreach webinar outlines the expanded need for workers in the wind industry and provides an overview of the DOE Wind Competition (to be held in May 2014) and the guiding principles of the competition.

  12. Competition in european electric market

    International Nuclear Information System (INIS)

    Electricity prices in Western Europe have dropped in recent years, especially for large industrial clients, as a result of liberalisation and the introduction of competition. This article, however, reflects on the conditions required for effective competition. A number of currently overlooked issues are emerging, which could bring to a substantial rise in electricity prices in the future

  13. The need for competitive intelligence.

    Science.gov (United States)

    MacStravic, R S

    1989-01-01

    Often associated with marketing warfare, competitive intelligence has become an essential part of health-care organizations' strategic planning efforts. Without overstepping ethical boundaries, providers can gather a vast array of "intelligence" about their competition from public sources, from the marketplace and from competitors themselves. PMID:10303102

  14. How to use competitive intelligence.

    Science.gov (United States)

    MacStravic, R S

    1989-02-01

    Keeping tabs on the competition is a necessity, not a luxury, for organizations operating in today's health-care marketplace. This article, the second of two, explores various strategies for using competitive intelligence and suggests ways to ensure organization-wide commitment to gathering and using this information as part of an overall strategic plan. PMID:10291747

  15. Competitive strategy a new era.

    Science.gov (United States)

    Zuckerman, Alan M

    2007-11-01

    By adopting five basic practices, your organization will be ready to advance to the next level of competitive fitness: Develop a reliable financial baseline. Insist on development of a competitive intelligence database system. Employ rigorous business planning. Advocate for focus and discipline. Really commit to competing. PMID:18018789

  16. MEASURING COMPETITIVENESS OF ECONOMIC ENTITIES

    Directory of Open Access Journals (Sweden)

    MUNGIU-PUPĂZAN MARIANA CLAUDIA

    2013-12-01

    Full Text Available A competitive structure of a national economy is influenced by the competitiveness of each of the actors made the national economy. In other words, to achieve competitive economic structure shall contribute all sectors of the national economy and hence all branches of the national economy, all organizations within each branch. Thus, the productive sectors of the economy contribute by increasing their competitiveness, GDP growth, added value, while other branches making a contribution through activity, increased quality of life (health, culture, social in training skilled labor (education to ensure effective functioning of the judiciary, protection of private property and citizen safety, lower crime rate (police, reducing the risk of political instability, increasing social cohesion, social disparities (richness and extreme poverty, and discrimination against women and minority groups. Human resources are probably the most important factor determining the competitiveness of an area. The ability of a country to move up the value chain is closely related to human resource capability. In understanding the competitive evaluation is important to assess not only in terms of education, improvement, skills and work experience, but also in terms of other attributes, more difficult to measure, as entrepreneurial relationships, creativity and risk tolerance. Secondly, we must accept that individual productivity is determined by external factors. Latent potential of the individual can develop when the person moves to another environment that provides better and more opportunities. Currently structural changes to remain competitive obtaining essential parameters of the Romanian economy to cope with competitive pressures of the single European market.

  17. The Africa Competitiveness Report 2011

    OpenAIRE

    World Economic Forum; World Bank; African Development Bank

    2011-01-01

    The Africa competitiveness report 2011 comes out as the world emerges from the most significant financial and economic crisis in generations. While many advanced economies are still struggling to get their economies back on a solid footing, Africa has, for the most part, weathered the storm remarkably well. The Africa competitiveness report focuses on harnessing Africa's underutilized reso...

  18. Competitive dimensions of human resources

    Directory of Open Access Journals (Sweden)

    Neykova Rumyana Mykolaivna

    2015-02-01

    Full Text Available This article deals with the essence of human resources competitive dimensions. Their competitive priorities are analyzed in dynamic business environment, with an emphasis on the quality of human resources, their adaptive skills, communication skills and mobility. The attention is paid to the role behavior of personnel and the policies for its management in the context of cutting down management costs.

  19. Competitive dimensions of human resources

    OpenAIRE

    Neykova Rumyana Mykolaivna; Prokopenko Olha Volodymyrіvna; Shcherbachenko Viktoriia Oleksiivna

    2015-01-01

    This article deals with the essence of human resources competitive dimensions. Their competitive priorities are analyzed in dynamic business environment, with an emphasis on the quality of human resources, their adaptive skills, communication skills and mobility. The attention is paid to the role behavior of personnel and the policies for its management in the context of cutting down management costs.

  20. A Learning Software Design Competition.

    Science.gov (United States)

    Hooper, Simon; Hokanson, Brad; Bernhardt, Paul; Johnson, Mark

    2002-01-01

    Explains the University of Minnesota Learning Software Design Competition, focusing on its goals and emphasis on innovation. Describes the review process to evaluate and judge the software, lists the winners, identifies a new class of educational software, and outlines plans for future competitions. (Author/LRW)

  1. Environmental protection and competition policy

    International Nuclear Information System (INIS)

    The area 'Environmental protection and competition policy' follows the introductory guideline by Sir Leon Brittan, vice-president of the EC-Commission: 'We must seek the most market driven, dynamic approach to solutions, such that competition and technological advance bring the maximum economic and environmental benefits'. From this concrete measures are derived. (HSCH)

  2. Competitive Capacity Investment under Uncertainty

    NARCIS (Netherlands)

    X. Li (Xishu); R.A. Zuidwijk (Rob); M.B.M. de Koster (René); R. Dekker (Rommert)

    2016-01-01

    textabstractWe consider a long-term capacity investment problem in a competitive market under demand uncertainty. Two firms move sequentially in the competition and a firm’s capacity decision interacts with the other firm’s current and future capacity. Throughout the investment race, a firm can eith

  3. A Survey of Robotic Competitions

    OpenAIRE

    Richard Balogh

    2005-01-01

    A survey of robotic competitions all over the world, their short history and present state is given. Contests are classified according to their difficulty and conditions. Typical competition categories, also with interesting robot constructions are described. Sense, advantages and disadvantages of contests are discussed, especially concerning educational purposes. At the same time, our experiences with organising the contest Istrobot are pre...

  4. Optimal Forest Conservation: Competitiveness Versus Green Image Effects

    OpenAIRE

    Koskela, Erkki; Ollikainen, Markku

    2000-01-01

    This paper provides a theoretical framework to study the behavioral and welfare effects of forest conservation, which leads to a binding harvesting constraint for landowners. The economy is modeled as a three-stage game by the interaction of the government’s conservation policy, with consequent adjustments in domestic timber market, and in output determination in a Cournot rivalry with the foreign forest industry. More specifically, we study how forest industry’s competitiveness constrains fo...

  5. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  6. EU Competition Policy Since 1990

    DEFF Research Database (Denmark)

    Bartalevich, Dzmitry

    2013-01-01

    In spite of the evidence of strong influence on the incorporation of policy provisions from the U.S. antitrust into the recent competition policy reforms in the European Union (EU), few considerable attempts have been made to analyze the influence of U.S. antitrust on EU competition policy in...... anticartel enforcement policies, antimonopoly regulation, and the regulation of mergers and acquisitions. The purpose of this article is to fill the gap by attempting to link EU competition policy with U.S. antitrust, provide a critical overview of the most important elements of European competition policy...... reforms, carry out a comparative analysis between EU and U.S. competition policies, detect convergence or divergence, and account for the degree of convergence and for the relevant mechanisms triggering convergence. The main focus is on the analysis of anticartel enforcement policy, antimonopoly policy...

  7. COMPETITIVE PRODUCT ADVANTAGES

    Directory of Open Access Journals (Sweden)

    Adrian MICU

    2006-01-01

    Full Text Available Cost advantages may be either internal or external. Internal economics of scope, scale, or experience, and external economies of focus or logistical integration, enable a company to produce some products at a lower cost than the competition. The coordination of pricing with suppliers, although not actually economizing resources, can improve the efficiency of pricing by avoiding the incrementalization of a supplier's nonincremental fixed costs and profit. Any of these strategies can generate cost advantages that are, at least in the short run, sustainable. Even cost advantages that are not sustainable, however, can generate temporary savings that are often the key to building more sustainable cost or product advantages later.. Even when a product's physical attributes are not readily differentiable, opportunities to develop product advantages remain. The augmented product that customers buy is more than the particular product or service exchanged. It includes all sorts of ancillary services and intangible relationships that make buying thesame product from one company less difficult, less risky, or more pleasant than buying from a competitor. Superior augmentation of the same basic product can add substantial value in the eyes of consumers, leading them to pay willingly what are often considerable price premiums.

  8. Randomness in Competitions

    CERN Document Server

    Ben-Naim, E; Redner, S; Vazquez, F

    2012-01-01

    We study the effects of randomness on competitions based on an elementary random process in which there is a finite probability that a weaker team upsets a stronger team. We apply this model to sports leagues and sports tournaments, and compare the theoretical results with empirical data. Our model shows that single-elimination tournaments are efficient but unfair: the number of games is proportional to the number of teams N, but the probability that the weakest team wins decays only algebraically with N. In contrast, leagues, where every team plays every other team, are fair but inefficient: the top $\\sqrt{N}$ of teams remain in contention for the championship, while the probability that the weakest team becomes champion is exponentially small. We also propose a gradual elimination schedule that consists of a preliminary round and a championship round. Initially, teams play a small number of preliminary games, and subsequently, a few teams qualify for the championship round. This algorithm is fair and effici...

  9. Driving Competitiveness Through Servitization

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Frandsen, Thomas; Hsuan, Juliana;

    Servitization, or adding services to the manufactured product, has become a strategy for increasing financial margins, getting closer to the customer and prolonging product lives. This is especially applicable to Western hemisphere companies in their efforts to compete with companies from low cos...... for the company. This booklet is produced to serve as a documentation of a research project together with industry on how servitization can be a strategy to enhance the competitiveness of manufacturing firms.......Servitization, or adding services to the manufactured product, has become a strategy for increasing financial margins, getting closer to the customer and prolonging product lives. This is especially applicable to Western hemisphere companies in their efforts to compete with companies from low cost...... countries and emerging economies. It is our hope that this booklet can assist managers to analyze and plan a servitization strategy. The text is brief and comprehensive to supplement a workshop, but can also be used separately as a quick guide on steps to follow for a manager when considering servitization...

  10. Energy levy and competitiveness

    International Nuclear Information System (INIS)

    The principle of regulating levies is that the consumption of products that have negative effects on the environment will be reduced. The income of the levies can be reimbursed to the civilians and companies via tax reduction. One of the impacts of the implementation of energy levies is the negative effect on the competitive position of the Dutch industry and businesses. In this report attention is paid to the micro-economic consequences of energy levies. The flows of fifteen production processes and the position of these processes in the market have been analyzed systematically. The impacts of energy levies on these product flows are investigated. The sectors that have been analyzed are the services sector (mainly determined by households), the agricultural food sector, the transportation sector, and the basic industry (mostly energy-intensive industries). In order to determine the sensitivity of the height of the energy levy three variants were investigated: 25%, 50% and 100% surcharge on the present energy costs. The variants are combined with three geographic levy ranges: national, European and global. 21 figs., 9 tabs

  11. Customer-driven competition

    International Nuclear Information System (INIS)

    Ontario Hydro's customer-driven strategy, recently approved by Hydro's Executive Board, was described. The strategy is founded on the following components: (1) the dissolution of the Ontario power pool, i.e., the loss of Hydro's franchise monopoly on generation, leaving only power transmission in the hands of the Corporation, (2) divestment of Ontario Hydro's system operations and market operations functions to a new, independent Crown corporation called the Central Market Operator, (3) functional and organizational unbundling of Ontario Hydro into three signature businesses, Genco, Transco, and Retailco, and in the latter two, the functional unbundling of wires from sales and services, (4) a fully commercial Ontario Hydro with normal corporate powers, and (5) a corporate strategy for Ontario Hydro to grow in businesses in an open, symmetrical North American energy market. According to Ontario Hydro management this will allow competition and choice to all customers, have a disciplining effect on prices, and give rise to a retail market of new products and services, while at the same time preserve and enhance the value of public investment in the Corporation

  12. 5 CFR 351.403 - Competitive level.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Competitive level. 351.403 Section 351... FORCE Scope of Competition § 351.403 Competitive level. (a)(1) Each agency shall establish competitive levels consisting of all positions in a competitive area which are in the same grade (or...

  13. Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines

    Directory of Open Access Journals (Sweden)

    Bolton Michael J

    2011-11-01

    Full Text Available Abstract Background The HIV surface glycoprotein gp120 (SU, gp120 and the Plasmodium vivax Duffy binding protein (PvDBP bind to chemokine receptors during infection and have a site of amino acid sequence similarity in their binding domains that often includes a heparin binding motif (HBM. Infection by either pathogen has been found to be inhibited by polyanions. Results Specific polyanions that inhibit HIV infection and bind to the V3 loop of X4 strains also inhibited DBP-mediated infection of erythrocytes and DBP binding to the Duffy Antigen Receptor for Chemokines (DARC. A peptide including the HBM of PvDBP had similar affinity for heparin as RANTES and V3 loop peptides, and could be specifically inhibited from heparin binding by the same polyanions that inhibit DBP binding to DARC. However, some V3 peptides can competitively inhibit RANTES binding to heparin, but not the PvDBP HBM peptide. Three other members of the DBP family have an HBM sequence that is necessary for erythrocyte binding, however only the protein which binds to DARC, the P. knowlesi alpha protein, is inhibited by heparin from binding to erythrocytes. Heparitinase digestion does not affect the binding of DBP to erythrocytes. Conclusion The HBMs of DBPs that bind to DARC have similar heparin binding affinities as some V3 loop peptides and chemokines, are responsible for specific sulfated polysaccharide inhibition of parasite binding and invasion of red blood cells, and are more likely to bind to negative charges on the receptor than cell surface glycosaminoglycans.

  14. Climate policy and European competition positions

    International Nuclear Information System (INIS)

    Environmental policy has an effect on the competitiveness of firms. As a result, they export less or are forced to move to countries with less stringent policies. Insight into the occurrence of such effects is relevant for the development of appropriate environmental policies, Especially for a small open economy such as the Netherlands understanding the effect is relevant: a rather common fear is that environmental policy will badly hurt some firms and sectors and will distress the Dutch economy. This fear is only amplified by the decision of the United States to withdraw from the Kyoto protocol. American firms will see their position on international markets vis-a-vis their European competitors. In fact, an important reason for the United States to withdraw, is the perceived negative effect of Kyoto on the competitiveness on American firms. Moreover, relocation may undermine the effectiveness of climate change policy. Emission increases in countries without binding restrictions may partly offset emission reductions that are induced by climate change policy. A qualitative as well as a quantitative review of the consequences of climate change policies for (specific sectors in) European countries, among which the Netherlands, is given. Therefore, a two-track research strategy was followed: (1) a review of the theoretical and empirical literature that addresses the impact of more stringent environmental policies on exports and location choices; and (2) quantification of the effects of climate policy on national income and sectoral employment with WorldScan, a dynamic applied general equilibrium model

  15. A very competitive oil

    International Nuclear Information System (INIS)

    Drop in oil barrel prices results in 8 to 10 billions in savings for French companies, i.e. as much as the tax credit for competitiveness and employment. This article analyses how the different sectors take benefit of this saving due to lower oil prices. It outlines that this decrease has been very profitable for the refining sector which exhibited historic margins. As far as the chemistry sector is concerned, costs are reduced but profits are less important as this decrease compensates the decrease of the euro with respect to the dollar. The plastic industry does not take profit as it comes at the end of value chain where other actors already took their benefits. Therefore, there is no profit in agriculture as far as plastic products and fertilizers are concerned. On the opposite, the decrease of marine fuel has been profitable to the fishing sector as well as to the sea transport sector. As far as road transport is concerned the fuel price decrease is reflected in resale prices, and the oil price decrease had therefore no impact, or only for few days. It's not the case for air transport where companies took benefit of this decrease. In this respect, a second article outlines that airline companies have learned lessons from previous oil price counter-shock to adapt their strategies. The last article addresses the general situation of industry which exhibits a better financial health, could be boosted by a recovery of consumption. But growth is still to be confirmed by investments. A brief article notices that the profit is less important at the world level, i.e. more important in Europe than in Asia and even more than in Africa

  16. Marketing Aspect of Banking Competition

    Directory of Open Access Journals (Sweden)

    Nieizviestna Olena V.

    2015-03-01

    Full Text Available The aim of the article is to study the need for application of marketing tools in order to improve competitiveness and competitive advantages of banks. By analyzing, systematizing and summarizing the scientific works of many scientists, the relationship between the competitiveness of the commercial bank and its share in the banking market has been discovered. In the process of studying the integration of the strategy of maximizing customer satisfaction in the practice of strategic competition in the banking market there was presented the author’s position regarding the need to take into account the structure of the customer loyalty, as it is it that helps to properly distribute the bank’s marketing efforts. It has been proved that the technology of bank marketing should not only include the systems of identifying customer needs, creation of new financial products, but also contribute to the formation of the multi-factor strategic model of competitive strategy of the bank competitive development. It has been proposed to use the SWOT-analysis in order to effectively manage the bank’s competitiveness.

  17. Actual competition, potential competition, and bank profitability in rural markets

    OpenAIRE

    Gary Whalen

    1988-01-01

    An empirical study of the relationship between market concentration and bank performance in rural markets, examining both actual and potential competition and controlling for risk, market share, and simultaneity.

  18. Romania's Competitiveness and Competitive Position in Global Context

    Directory of Open Access Journals (Sweden)

    Valentin NECULITA

    2012-08-01

    Full Text Available Competitiveness increase has become a primordial framework of the social and economic development strategies of most world countries (mainly the most developed ones over the last decades. The vigorous boost of the contemporary phenomenon of globalization, which has widened the global area of economies, sectors and firms confrontation, has laid an emphasis on their competitiveness importance for their favorable position in the international competition and has therefore force the status to take proper, broad and concerted measures to stimulate the determining factors of action and to take better advantage of their effects. The purpose of the paper is to determine whether an increase in competitiveness could reduce the disparities between regions. The E.U. Member States and regions need significant financial help to solve various structural problems and to achieve their potential of growth. Romania is no exception, one of the main problems being the low rate in attracting European funds.

  19. Testosterone, cortisol, and human competition.

    Science.gov (United States)

    Casto, Kathleen V; Edwards, David A

    2016-06-01

    Testosterone and cortisol figure prominently in the research literature having to do with human competition. In this review, we track the history of this literature, concentrating particularly on major theoretical and empirical contributions, and provide commentary on what we see as important unresolved issues. In men and women, athletic competition is typically associated with an increase in testosterone (T) and cortisol (C). Hormone changes in response to non-athletic competition are less predictable. Person (e.g., power motivation, mood, aggressiveness, social anxiety, sex, and baseline levels of T and C) and context (e.g., whether a competition is won or lost, the closeness of the competition, whether the outcome is perceived as being influenced by ability vs. chance, provocations) factors can influence hormone responses to competition. From early on, studies pointed to a positive relationship between T and dominance motivation/status striving. Recent research, however, suggests that this relationship only holds for individuals with low levels of C - this is the core idea of the dual-hormone hypothesis, and it is certain that the broadest applications of the hypothesis have not yet been realized. Individuals differ with respect to the extent to which they embrace competition, but the hormonal correlates of competitiveness remain largely unexplored. Although rapid increases in both T and C associated with competition are likely adaptive, we still know very little about the psychological benefits of these hormonal changes. Administration studies have and will continue to contribute to this inquiry. We close with a discussion of what, we think, are important methodological and mechanistic issues for future research. PMID:27103058

  20. Competitive Pressure: Competitive Dynamics as Reactions to Multiple Rivals

    OpenAIRE

    Zucchini, Leon; Kretschmer, Tobias

    2011-01-01

    Competitive dynamics research has focused primarily on interactions between dyads of firms. Drawing on the awareness-motivation-capability framework and strategic group theory we extend this by proposing that firms? actions are influenced by perceived competitive pressure resulting from actions by several rivals. We predict that firms? action magnitude is influenced by the total number of rival actions accumulating in the market, and that this effect is moderated by strategic group membership...

  1. Distributed Wind Competitiveness Improvement Project

    Energy Technology Data Exchange (ETDEWEB)

    2016-05-01

    The Competitiveness Improvement Project (CIP) is a periodic solicitation through the U.S. Department of Energy and its National Renewable Energy Laboratory. Manufacturers of small and medium wind turbines are awarded cost-shared grants via a competitive process to optimize their designs, develop advanced manufacturing processes, and perform turbine testing. The goals of the CIP are to make wind energy cost competitive with other distributed generation technology and increase the number of wind turbine designs certified to national testing standards. This fact sheet describes the CIP and funding awarded as part of the project.

  2. Western Canada Sedimentary Basin competitiveness

    International Nuclear Information System (INIS)

    Recent dramatic expansion of the natural gas industry in the Western Canada Sedimentary Basin provided ample proof of the potential of this area for further development of natural gas supply. However, the inherent competitive advantages provided by the Western Canada Sedimentary Basin were said to have been offset by low netback prices resulting in poor producer economics when competitiveness is measured by availability of opportunities to find and develop gas supply at costs low enough to ensure attractive returns. Technology was identified as one of the key elements in improving basin competitiveness, but the greatest potential lies in reduced transportation costs and increased access to North American market centres. 8 figs

  3. Utility regulation and competition policy

    International Nuclear Information System (INIS)

    Contents: 1. The New Electricity Trading Arrangements in England and Wales: A Review - David Currie, 2. A Critique of Rail Regulation - Dieter Helm, 3. Moving to a Competitive Market in Water - Colin Robinson, 4. The New Gas Trading Arrangements - George Yarrow, 5. A Review of Privatization and Regulation Experience in Britain - Irwin M. Stelzer, 6. Converging Communications: Implications for Regulation - Mark Armstrong, 7. Opening European Electricity and Gas Markets - Graham Shuttleworth, 8. Concurrency or Convergence? Competition and Regulation Under the Competition Act 1998 - Tom Sharpe QC, 9. Ten Years of European Merger Control - Paul Seabright. (Author)

  4. Regional Competitiveness Management And Competitive Status Of Regions Under Conditionsof The Russian Economy Internationalization

    OpenAIRE

    L. Simonova; Pogodaeva, T

    2007-01-01

    The article describes the actual issues of forming the management system of competitiveness on region levels and developing the model of region competitiveness estimate. Also the way institutional environment and marketing infrastructure institutions influence on competitiveness of region economy is considered. The competitiveness of the Russian regions is evaluated. Differences in competitiveness level for general types of regions are determined. Recommendations for improving competitiveness...

  5. REGULATION AND ENFORCEMENT OF COMPETITION POLICY

    OpenAIRE

    Liviana Andreea Niminet

    2014-01-01

    Competition policy starts by shaping a legislative framework. This is aimed to establish boundaries for conducting competition and also sets limits of licit and illicit demarcation, for competitive and anticompetitive practices. The Romanian Competition Law has a divalent approach and it aims to provide specific behavioral conditions in order to stimulate and protect free-market competition, with the ultimate goal of developing a balanced, efficient and competitive economy. Our country’s Comp...

  6. Development and goals of competition law

    OpenAIRE

    Mateusz Blachucki

    2013-01-01

    The article presents the historical development of competition law discussing reasons for adopting particular national antimonopoly legislation. The following analysis of goals of competition law leads to the conclusion that there is no agreement what goals competition law should have. Furthermore some of identified goals of competition law are conflicting. Nonetheless the majority of national competition laws and the academics accept that competition law should aim at achieving the basic eco...

  7. Global Competitiveness Index and economic growth

    OpenAIRE

    Cazacu, Ana-Maria

    2015-01-01

    In this paper, we examine the linkage between economic growth and competitiveness on a panel of 28 European countries, during 2006-2013. We use Global Competitiveness Index (GCI) as a measure of national competitive capacities and find that a shock in competitiveness has a positive impact on GDP developments. Nevertheless, the results show that fast economic growth has a small positive effect on competitiveness, as increasing the competitive capacity of a nation is linked to many other factor...

  8. Regional Competitiveness and Its Implications for Development

    OpenAIRE

    Daryono Soebagyo; Triyono Triyono; Yuli Tri Cahyono

    2015-01-01

    This study was conducted to identify regional competitiveness in some areas of Central Java. Regional competitiveness became one of the issues in regional development policy since the enactment of local autonomy.Measurement of regional competitiveness has been mostly done through ranking as a benchmark the competitiveness of the region. Mapping regional competitiveness in Indonesia has been made to all counties and cities, which shows the competitiveness ranking of each region. Competitivenes...

  9. Competitive Strategy in Continuing Education.

    Science.gov (United States)

    Baden, Clifford

    1987-01-01

    Reviews strategic variables available to those planning continuing education marketing programs. Discusses generic competitive strategies: (1) overall cost leadership, (2) differentiation, and (3) specialization. Mentions several potential problems. (CH)

  10. Competitiveness Model of Bioethanol Industry

    Directory of Open Access Journals (Sweden)

    Muzakar Isa

    2013-12-01

    Full Text Available The need for energy is increasing every year. More than 80% of energy needs met by fossil fuels derived from petroleum and natural gas. To anticipate, the Government issued Presidential Regulation No. 5 of 2006 on the national energy. In this regulation, the government took steps to saving energy and looking for new sources of energy that are renewable and environmentally friendly. One is bioethanol. This study aims to analyze the competitiveness of bioethanol industry in Bekonang Sukoharjo. This study used mixed methods, namely the incorporation of quantitative and qualitative methods in a single study. The measurement of competitiveness is using Porter's Diamond Model. The results show the competitiveness of bioethanol industry is influenced by business strategy, potential buyers, working capital and innovation. Currently, bioethanol industry competitiveness is low.

  11. Logistics systems optimization under competition

    DEFF Research Database (Denmark)

    Choi, Tsan Ming; Govindan, Kannan; Ma, Lijun

    2015-01-01

    Nowadays, optimization on logistics and supply chain systems is a crucial and critical issue in industrial and systems engineering. Important areas of logistics and supply chain systems include transportation control, inventory management, and facility location planning. Under a competitive market...

  12. The Power Trading Agent Competition

    OpenAIRE

    Ketter, W.; Collins, J.; REDDY, P; Flath, C.

    2011-01-01

    This is the specification for the Power Trading Agent Competition for 2011 (Power TAC 2011). Agents are simulations of electrical power brokers, who must compete with each other for both power production and consumption, and manage their portfolios.

  13. The Scientific Competitiveness of Nations

    CERN Document Server

    Cimini, Giulio; Labini, Francesco Sylos

    2014-01-01

    We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems. We characterize the scientific fitness of each nation$-$that is, the competitiveness of its research system$-$and the complexity of each scientific domain by means of a non-linear iterative algorithm able to assess quantitatively the advantage of scientific diversification. We find that technological leading nations, beyond having the largest production of scientific papers and the largest number of citations, do not specialize in a few scientific domains. Rather, they diversify as much as possible their research system. On the other side, less developed nations are competitive only in scientific domains where also many other nations are present. Diversification thus represents the key element that correlates with scientific and technological competitiveness. A remarkable implication of this structure of the scientific competition is...

  14. Quantitative assessment of factors affecting the sensitivity of a competitive immunomicroarray for pesticide detection

    DEFF Research Database (Denmark)

    Belleville, Erik; Dufva, Hans Martin; Aamund, J.,;

    2003-01-01

    Analytical protein microarrays offering highly parallel analysis can become an invaluable tool for a wide range of immunodiagnostic applications. Here we describe factors that influence the sensitivity of a competitive immunomicroarray that quantifies small molecules; in this case, the pesticides...... dichlobenil metabolite 2,6-dichlorobenzamide (BAM) and atrazine. Free pesticide concentrations in solution are quantified by the competitive binding of fluorescence-conjugated monoclonal antibodies to either surface-immobilized pesticide hapten-protein conjugates or pesticides in solution. We investigated the...

  15. Competition in Bureaucracy and Corruption.

    OpenAIRE

    Drugov, Mikhail

    2007-01-01

    This paper studies the consequences of introducing competition between bureaucrats. Bureaucrats are supposed to grant licences to firms that satisfy certain requirements. Firms have to invest into satisfying these requirements. Some bureaucrats are corrupt, that is, they give the licence to any firm in exchange for a bribe. Some firms prefer to buy the licence rather than to invest and satisfy the requirements imposing negative externalities on the society. The competition regime is found to ...

  16. Mathematical Competitions for University Students

    OpenAIRE

    Alexander Domoshnitsky; Roman Yavich

    2013-01-01

    We present several possible forms of mathematical competitions for University students. One of them is Blitz Mathematical Olympiad. It is a team competition, when all teams receive the same problem and are allotted 10-15 minutes to come up with a solution. This cycle is repeated 6-8 times with different problems. Modern Internet technologies allow us to organize Blitz Mathematical Olympiads for the teams which are in different cities and even countries.

  17. Competition, Altruism, and Provider Payment

    OpenAIRE

    Karen Eggleston

    2004-01-01

    Health care policymakers in many countries seek to use incentives and competition to spur efficiency. One important challenge is to mitigate the sacrifice of social solidarity that such reforms entail, because strong incentives promote risk selection. This paper argues conceptually and presents simulations revealing how competition, altruism, and payment incentives affect efficiency and equity of treatment. The focus is how to prevent or minimize incentives for quality distortions designed to...

  18. Farm Tourism and Spatial Competition

    OpenAIRE

    Andersson, Hans; Hoffmann, Ruben

    2008-01-01

    Changes in EU agricultural policies towards an increased focus on rural development issues raise questions regarding the economic impact of local and regional spatial competition. Farmers are typically price takers in the traditional markets for the major agricultural products. This is, however, not necessarily the case for “new enterprises” active in local and regional markets. This paper examines local/regional spatial competition for farm tourism. A spatial econometrics framework is applie...

  19. Understanding Competition in Spine Care.

    Science.gov (United States)

    Sharan, Alok D; Schroeder, Gregory D; West, Michael E; Vaccaro, Alexander R

    2016-04-01

    The changing landscape from volume to value represents a natural transformation in the health care industry. Increasingly provider groups are finding themselves responding to unfamiliar market forces. Whether explicit or implicit, competition is playing a larger role for the sustainability of providers. For spine care providers who are attempting to navigate the transition from volume to value, understanding the forces that shape competition in health care can help achieve success. PMID:26925860

  20. Firm in a competitive environment

    OpenAIRE

    Červenková, Kristýna

    2013-01-01

    This thesis deals with problems of the company in a competitive environment. In the overview of issues to be solved are discussed characteristics of competition, both perfect and imperfect. Further is specified external and internal business environment with the introduction of 3 selected analyzes of both worlds. Conclusion of the overview of issues dealing with SWOT analysis, based on previous analyzes. Custom work contents 2 questionnaires the questionnaire surveys, the questions are direct...

  1. Tax Competition and Public Input

    OpenAIRE

    Agnès Bénassy-Quéré; Nicolas Gobalraja; Alain Trannoy

    2005-01-01

    This paper assesses the extent and policy implications of simultaneous competition among countries on both corporate tax rates and the provision of public goods used by firms as production factors (‘public factors’). First, we derive the relevant theoretical results in a unified framework where a corporate tax is used to finance a public good that raises both household utility and firm productivity. Then, the relevance of such simultaneous competition is tested using data on foreign direct in...

  2. Competitiveness of the European economy

    OpenAIRE

    Landesmann, Michael; Leitner, Sandra; Stehrer, Robert

    2015-01-01

    Summary This paper uses the World Input-Output Database (WIOD) to analyse changes of Europe’s position in global specialisation and location patterns of exporting activity within Europe by means of a number of competitiveness indicators. We consider both manufacturing as well as tradable services. The study analyses the increasing role of services–industry linkages, the differentiation in specialisation and competitiveness patterns amongst groups of EU member countries pointing to the increas...

  3. International Competitiveness of Sugar Production

    OpenAIRE

    Zimmermann, Beate; Zeddies, Jurgen

    2002-01-01

    Sugar market is one of the most protected markets for agricultural products world wide. In almost every sugar producing country the sugar market is regulated in some way. With an increasing liberalization of agricultural trade in the "Millennium Round" of the WTO trade negotiations, the question of international competitiveness is of increasing importance. Based on empirical studies, in this article the competitiveness of sugar production in the most important sugar producing countries is ana...

  4. Digital product piracy and competition

    OpenAIRE

    Okçuoğlu, Dilan; Okcuoglu, Dilan

    2011-01-01

    This thesis studies the optimal copyright protection level for a single firm. We consider two market settings: monopoly and duopoly under Cournot competition. We also analyze the optimal level in Cournot setting in two subsections: with and without a cost of implementing protection. The optimal level for the monopolist without any potential competitors is full protection. Under competition, for sufficiently high fixed cost values, the monopolist firm chooses a level which is below the monopol...

  5. Combinatorial problems in mathematical competitions

    CERN Document Server

    Yao, Zhang

    2011-01-01

    This book focuses on combinatorial problems in mathematical competitions. It provides basic knowledge on how to solve combinatorial problems in mathematical competitions, and also introduces important solutions to combinatorial problems and some typical problems with often-used solutions. Some enlightening and novel examples and exercises are well chosen in this book. With this book, readers can explore, analyze and summarize the ideas and methods of solving combinatorial problems. Their mathematical culture and ability will be improved remarkably after reading this book.

  6. How competition affects evolutionary rescue

    OpenAIRE

    Osmond, Matthew Miles; de Mazancourt, Claire

    2013-01-01

    Populations facing novel environments can persist by adapting. In nature, the ability to adapt and persist will depend on interactions between coexisting individuals. Here we use an adaptive dynamic model to assess how the potential for evolutionary rescue is affected by intra- and interspecific competition. Intraspecific competition (negative density-dependence) lowers abundance, which decreases the supply rate of beneficial mutations, hindering evolutionary rescue. On the other hand, inters...

  7. International Competition: The Japanese Challenge

    OpenAIRE

    Keegan, Warren J.

    1984-01-01

    The Japanese success in international competition has attracted much attention. To date, little of this attention has addressed the role of marketing in the Japanese success. This note focuses on the Japanese approach to strategic market planning and its role in contributing to the competitive strength of Japanese enterprise.The author identifies the major elements of the Japanese approach and concludes that there is nothing new in Japanese marketing. The Japanese advantage is not in secret o...

  8. Internet service classes under competition

    OpenAIRE

    Gibbens, R.; R. Mason; Steinberg, Richard

    2000-01-01

    This paper analyzes competition between two Internet service providers (ISPs), either or both of which may choose to offer multiple service classes. In the model analyzed, a social planner who maximizes the total benefit from network usage and a profit maximizing monopolist will both form multiple service classes; but two networks competing to maximize profits will not. The reason is that a competition effect always outweighs a segmentation effect. Networks wish to offer multiple service clas...

  9. The Effects of Tax Competition

    Directory of Open Access Journals (Sweden)

    Ioan TALPOŞ

    2010-08-01

    Full Text Available Tax competition between governments is a research topic of growing importance in the context of globalization. This subject is particularly important for the European Union, characterized by a high degree of economic integration, single currency and free movement of goods, services, persons and capital. In this paper we define the concept of tax competition and we provide a review of the literature to highlight its potential effects.

  10. The Effects of Tax Competition

    OpenAIRE

    Ioan TALPOŞ; Alexandru O. CRÂŞNEAC

    2010-01-01

    Tax competition between governments is a research topic of growing importance in the context of globalization. This subject is particularly important for the European Union, characterized by a high degree of economic integration, single currency and free movement of goods, services, persons and capital. In this paper we define the concept of tax competition and we provide a review of the literature to highlight its potential effects.

  11. Option compensation and industry competition

    OpenAIRE

    Wong, KP; Stoughton, NM

    2009-01-01

    Compensation policy has become one of the most important ingredients of corporate governance. In this paper we take a new look at the issue, by contrasting the use of options with that of stock. We do this by integrating the repricing or resetting aspect of options with that of industrial structure. We show that industry competition may play an important role in dictating which form of compensation is optimal. When aggressive competition for key professional staff is an issue, the flexibility...

  12. Sectoral Leadership in International Competitiveness

    OpenAIRE

    2008-01-01

    The purpose of this paper is to identify the type of labour and the sectors where labour productivity should be improved to raise the international competitiveness of Portugal. A static multi-sectoral general equilibrium model, with multi-national and single-country versions is used. The model allows the identification of the sectors that are leaders in competitiveness improvement. It is expectable that for some countries this role should be played by the traditional exporting-sectors, while ...

  13. CAN INCOME EQUALITY INCREASE COMPETITIVENESS?

    OpenAIRE

    Fishman, Arthur; Simhon, Avi

    2003-01-01

    This paper explores the relationship between income distribution, prices, production efficiency and aggregate output in a decentralized search economy. We show that income distribution determines how competitive the market is, and thereby affects production efficiency and aggregate output. It is shown that it is generally possible to engineer a judicious transfer of income from high to low income individuals which simultaneously increases income equality, competitiveness, and aggregate output.

  14. Technology competition and regulatory advantage

    OpenAIRE

    Boscheck, Ralf

    2010-01-01

    The importance of competition law as a policy lever to help the EU compete at the forefront of science and technology seems to have been overlooked by the Commission. As a consequence, the EU appears to be at a disadvantage to the USA in terms of the regulatory environment for intellectual property and licensing practices. This article examines these differences and explores the pros and cons of the European and American approaches to competition law, ultimately arguing in favour of regulator...

  15. Advertising Dynamics and Competitive Advantage

    OpenAIRE

    Ulrich Doraszelski; Sarit Markovich

    2004-01-01

    Can advertising lead to a sustainable competitive advantage? To answer this question, we propose a dynamic model of advertising competition where firms repeatedly advertise, compete in the product market, and make entry as well as exit decisions. Within this dynamic framework, we study two different models of advertising: In the first model, advertising influences the goodwill consumers extend towards a firm ("goodwill advertising"), whereas in the second model it influences the share of cons...

  16. The Rationale behind Competitive Advantage

    OpenAIRE

    Daruka, Peeyush; Sakhalkar, Varuni

    2012-01-01

    In today’s volatile business environment, a sustainable competitive advantage is what every firm seeks. Much has been said and written on this topic but it has been observed that in their pursuit of growth and diversification, many companies lose out on competitive advantage. The recent economic crisis has but the brakes on growth and market share and the impact has been felt globally across various industries. Reduced customer confidence and spending have made matters worse and companies are...

  17. Coupled and competitive eutectic growth

    OpenAIRE

    M. Trepczyńska - Łent

    2011-01-01

    A description of the competitive growth is presented in the paper. The description is associated with the competition between eutectic structure and primary phase formation. A coupled zone for the eutectic solidification is drawn in the phase diagrams. The coupled zone is shown as a range of solute concentration versus under-cooling to justify the formation of the eutectic structure, exclusively. Interface growth temperatures of the single and coupled eutectic are illustrated schematically as...

  18. Competition, Takeovers and Gender Discrimination

    OpenAIRE

    Heyman, Fredrik; Svaleryd, Helena; Vlachos, Jonas

    2008-01-01

    Theories of taste-based discrimination predict that competitive pressures will drive discriminatory behaviour out of the market. Using detailed matched employer-employee data, we analyze how firm takeovers and product market competition are related to the gender composition of the firm’s workforce and the gender wage gap. Using a difference-in-difference framework and dealing with several endogeneity concerns, we find that the share of female employees increases as a result of an ownership ch...

  19. DXC'11 Industrial Track Competition Data

    Data.gov (United States)

    National Aeronautics and Space Administration — Competition data, including nominal and faulty scenarios, for Diagnostic Problem I of the Third International Diagnostic Competition. Three file formats are...

  20. DXC'10 Industrial Track Competition Data

    Data.gov (United States)

    National Aeronautics and Space Administration — Competition data, including nominal and faulty scenarios, for Diagnostic Problems I and II of the Second International Diagnostic Competition. Three file formats...

  1. Total iron binding capacity

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003489.htm Total iron binding capacity To use the sharing features on this page, please enable JavaScript. Total iron binding capacity (TIBC) is a blood test to ...

  2. Plant Hormone Binding Sites

    OpenAIRE

    Napier, Richard

    2004-01-01

    • Aims Receptors for plant hormones are becoming identified with increasing rapidity, although a frustrating number remain unknown. There have also been many more hormone‐binding proteins described than receptors. This Botanical Briefing summarizes what has been discovered about hormone binding sites, their discovery and descriptions, and will not dwell on receptor functions or activities except where these are relevant to understand binding.

  3. COMPETITION IN ROMANIAN BANKING SECTOR

    Directory of Open Access Journals (Sweden)

    Capraru Bogdan

    2011-07-01

    Full Text Available Recent turmoil in the global financial system has impacted severely on the banking sector with many banks suffering large losses and necessitating the need to raise additional capital privately or through their respective national governments. In our study we investigate the impact of structural reforms performed throughout the European Union (EU accession process on competition and contestability of banking systems in Romania. The literature of the measurement of competition can be divided into two major approaches: structural and non-structural. The structural approach to the assessment of competition embraces the Structure-Conduct-Performance Hypothesis (SCP and the Efficient Structure Hypothesis (ESH. The structural approach, as the name suggests, assesses bank competition by examining measures of market structure such as concentration ratios (the share of assets held by the top 3 or 5 institutions or indices (e.g., the Herfindhal-Hirschman index and supposes that higher concentration in the banking market causes less competitive bank conduct and leads to higher bank profitability. The SCP model is originally developed by Bain (1956. The second approach, ESH, developed by Demsetz (1973 and Peltzmann (1977 suggests that the superior performance of the market leaders determines the market structure, implying that higher efficiency produces both higher concentration and greater profitability. The non-structural indicators of competition are mainly based on the measures of monopoly power developed by Lerner (1934. The Lerner Index suggests the mark-up of price over marginal cost. An alternative non-structural indicator of the degree of market competition is the Panzar and Rosse (1987 H-statistic. The H-statistic measures the extent to which changes in banking costs are reflected in changes in banking revenues. In order to examine the level of competition and market power of banks in Romania for period 2003 - 2009, we estimate the non

  4. COMPETITIVE INTELLIGENCE ANALYSIS - SCENARIOS METHOD

    Directory of Open Access Journals (Sweden)

    Ivan Valeriu

    2014-07-01

    Full Text Available Keeping a company in the top performing players in the relevant market depends not only on its ability to develop continually, sustainably and balanced, to the standards set by the customer and competition, but also on the ability to protect its strategic information and to know in advance the strategic information of the competition. In addition, given that economic markets, regardless of their profile, enable interconnection not only among domestic companies, but also between domestic companies and foreign companies, the issue of economic competition moves from the national economies to the field of interest of regional and international economic organizations. The stakes for each economic player is to keep ahead of the competition and to be always prepared to face market challenges. Therefore, it needs to know as early as possible, how to react to others’ strategy in terms of research, production and sales. If a competitor is planning to produce more and cheaper, then it must be prepared to counteract quickly this movement. Competitive intelligence helps to evaluate the capabilities of competitors in the market, legally and ethically, and to develop response strategies. One of the main goals of the competitive intelligence is to acknowledge the role of early warning and prevention of surprises that could have a major impact on the market share, reputation, turnover and profitability in the medium and long term of a company. This paper presents some aspects of competitive intelligence, mainly in terms of information analysis and intelligence generation. Presentation is theoretical and addresses a structured method of information analysis - scenarios method – in a version that combines several types of analysis in order to reveal some interconnecting aspects of the factors governing the activity of a company.

  5. Use of monoclonal antibodies against avian retroviral protein p19 for competitive radioimmunoassay and immunodiffusion

    International Nuclear Information System (INIS)

    Monoclonal antibodies were used in competitive binding assays to investigate the arrangement of three epitopes on protein p19 of the avian myeloblastosis virus (AMV). It is reasoned that if the epitopes recognized by two monoclonal antibodies are physically close, the binding of one antibody will sterically block the binding of the other; conversely no blocking will occur if the epitopes are sufficiently distant. The results of these competitive binding assays demonstrated the presence of two distinct antigenic sites on protein p19. The monoclonal antibodies against protein p19 of AMV were also tested in gel double immunodiffusion. Since p19 protein shows strong tendency to aggregate, it was not surprising that clear precipitin lines with these monoclonal antibodies were obtained. (author)

  6. Flavonoids with M1 Muscarinic Acetylcholine Receptor Binding Activity

    Directory of Open Access Journals (Sweden)

    Meyyammai Swaminathan

    2014-06-01

    Full Text Available Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer’s disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (Ki = 40–110 µM, comparable to that of acetylcholine (Ki = 59 µM. Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.

  7. Binding of gliadin peptides to fetal chicken intestine

    International Nuclear Information System (INIS)

    Binding of gliadin peptides was investigated in intact and in homogenized fetal chicken intestine by means of competitive displacement studies with 125I-labelled PPG 12,400 (proteolysis product of gliadin, Mr 12,400). Gliadin binding was shown to be specific and calcium-dependent. Labelled gliadin can be displaced by morphine and naloxone. The specific binding of gliadin also depends on the developmental stage of the chicken intestine and decreases considerably from day 12-19 of fetal development. (author)

  8. Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule

    Energy Technology Data Exchange (ETDEWEB)

    Nordberg, Erika [Rudbeck Laboratory, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences, Uppsala University, SE-751 85 Uppsala (Sweden)], E-mail: erika.nordberg@bms.uu.se; Friedman, Mikaela [Department of Molecular Biotechnology, AlbaNova University Center, Kungl Tekniska Hoegskolan (KTH), SE-106 91 Stockholm (Sweden); Goestring, Lovisa [Rudbeck Laboratory, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences, Uppsala University, SE-751 85 Uppsala (Sweden); Affibody AB, PO Box 20137, SE-161 02 Bromma (Sweden); Adams, Gregory P. [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 (United States); Brismar, Hjalmar [Department of Cell Physics, AlbaNova University Center, Kungl Tekniska Hoegskolan (KTH), SE-106 91 Stockholm (Sweden); Nilsson, Fredrik Y. [Rudbeck Laboratory, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences, Uppsala University, SE-751 85 Uppsala (Sweden); Affibody AB, PO Box 20137, SE-161 02 Bromma (Sweden); Stahl, Stefan [Department of Molecular Biotechnology, AlbaNova University Center, Kungl Tekniska Hoegskolan (KTH), SE-106 91 Stockholm (Sweden); Glimelius, Bengt [Rudbeck Laboratory, Oncology, Radiology and Clinical Immunology, Uppsala University, SE-751 85 Uppsala (Sweden); Carlsson, Joergen [Rudbeck Laboratory, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences, Uppsala University, SE-751 85 Uppsala (Sweden)

    2007-08-15

    Introduction: The cellular binding and processing of an epidermal growth factor receptor (EGFR) targeting affibody molecule, (Z{sub EGFR:955}){sub 2}, was studied. This new and small molecule is aimed for applications in nuclear medicine. The natural ligand epidermal growth factor (EGF) and the antibody cetuximab were studied for comparison. Methods: All experiments were made with cultured A431 squamous carcinoma cells. Receptor specificity, binding time patterns, retention and preliminary receptor binding site localization studies were all made after {sup 125}I labeling. Internalization was studied using Oregon Green 488, Alexa Fluor 488 and CypHer5E markers. Results: [{sup 125}I](Z{sub EGFR:955}){sub 2} and [{sup 125}I]cetuximab gave a maximum cellular uptake of {sup 125}I within 4 to 8 h of incubation, while [{sup 125}I]EGF gave a maximum uptake already after 2 h. The retention studies showed that the cell-associated fraction of {sup 125}I after 48 h of incubation was {approx}20% when delivered as [{sup 125}I](Z{sub EGFR:955}){sub 2} and {approx}25% when delivered as [{sup 125}I]cetuximab. [{sup 125}I]EGF-mediated delivery gave a faster {sup 125}I release, where almost all cell-associated radioactivity had disappeared within 24 h. All three substances were internalized as demonstrated with confocal microscopy. Competitive binding studies showed that both EGF and cetuximab inhibited binding of (Z{sub EGFR:955}){sub 2} and indicated that the three substances competed for an overlapping binding site. Conclusion: The results gave information on cellular processing of radionuclides when delivered with (Z{sub EGFR:955}){sub 2} in comparison to delivery with EGF and cetuximab. Competition assays suggested that [{sup 125}I](Z{sub EGFR:955}){sub 2} bind to Domain III of EGFR. The affibody molecule (Z{sub EGFR:955}){sub 2} can be a candidate for EGFR imaging applications in nuclear medicine.

  9. GLOBAL COMPETITION AND ROMANIA’S NATIONAL COMPETITIVE ADVANTAGE

    Directory of Open Access Journals (Sweden)

    Pop Nicolae Alexandru

    2013-07-01

    Full Text Available Analyzing products and services around us it is clear that most of them are the result of production factors, labor and capital becoming more international and increasingly less and less national. We are witnessing the globalization of markets and production, to a large global integration and interdependence, increase personalization of production and services as a result of new communication systems interaction and flexible production processes. Markets will continue to homogenize and diversify at the same time, so it is important that as a global marketer one addresses a market segment defined by income, age, and consumption habits and not by membership of a nation. The most visible and polarized is the premium segment fighting for high income clients where brand value plays an important role. Instead identification of large segments of customers offers the advantages of scale economy in production and marketing for global enterprises. Consumer profile is the dominant global consumer requesting and accepting global products and services easily. In fact, what can force an economic alignment to achieve the best performance, rather than the global consumer. The research methodology used includes literature review, comparative analysis, synthesis of data based on bibliographic resources and official documents.The aim of the paper is to highlight current models that underlie the competitive advantage of nations and assess the competitive advantage of Romania in the context of the global market. A case study is used to offer an overview of competitive advantage of Antibiotice Iasi SA, a competitive player, in a global pharmaceutical market with strong global competition. Countries moderate companies’ achievements of global efficiency objectives due to the countries’ rivalry. Romania has to understand that it is in competition with other countries in order to fulfill economic, political and social objectives. The scope in the end is the well

  10. Current and future competitiveness of bioenergy - Conceptions about competitiveness

    International Nuclear Information System (INIS)

    It is important to visualize the conceptions that guide the behaviour of the actors within the energy system to be able to, in an efficient manner, increase the share of renewable energy in the energy mix. A major issue is to elucidate explicit and implicit presumptions within judgements on the competitiveness of bioenergy. This study focuses on how conceptions of bioenergy in the form of patterns of thinking, influence whether bioenergy can become competitive. The aim of the study is to develop a framework that will enable an increased understanding of the competitiveness of bioenergy today and in the future. The conceptions that the actors of the energy system uphold are studied and analysed. The conceptions of the actors are seen as key factors for the understanding of the function of the energy system and accordingly also for the understanding of the competitiveness of bioenergy. The over-all method perspective in the study is an actor approach. The actors' conceptions have been identified from interviews with 30 significant actors within the energy system. The material from the interviews has been synthesised into nine ideal types of actors. These nine 'model actors' are seen as representing the whole material and form the basis for the further analysis of the competitiveness of bioenergy as depending on patterns of thinking called logics. Three idealized logics are developed. The three logics developed in the study are production logic, market logic and socio-economic logic. (Upholders of the logics rank energy sources after production cost, profitability, and socio-economic legitimacy, respectively.) The logics co-exist within the different parts of the energy system. A single person can even uphold more than one logic. The three logics have however different weight in different organisations and in different parts of the energy system. Finally, the study proposes an enlarged description of the competitiveness of bioenergy in three dimensions: price

  11. MICROECONOMIC ANALYSIS IN COMPETITION POLICY

    Directory of Open Access Journals (Sweden)

    Paul Prisecaru

    2013-11-01

    Full Text Available This paper presents some of the most important microeconomic tools used in assessing antitrust and merger cases by the competition authorities. By explaining the way that microeconomic concepts like “market power”, “critical loss” or “price elasticity of demand” are used by the modern competition policy, the microeconomics scholar can get a practical perspective on the way that these concepts fit into the more general concept of “competition policy”. Extensive economic research has shown what are the market forces and economic factors that determine how cartels, which are at the core of antitrust policy, are established and sustained over time. One of the most important of these factors is the markets exposure to innovation, especially disruptive innovation. In these markets, the paradox, from a competition policy perspective, can be considered the fact that collusion is one of the least important concerns, due to the specific elements that determine the nature of competition.Instead, the main anticompetitive risk in the markets exposed to intensive innovation is unilateral conduct by which dominant incumbents can exclude competitors.

  12. Towards a Stakeholder Perspective on Competitive Advantage

    OpenAIRE

    Minyu Wu

    2013-01-01

    Competitive advantage and stakeholder management are two important research streams that have attractedmuch attention during the past few decades. Distinctive approaches to studies on competitive advantage exhibitdifferences in their assumptions, units of analysis, and strategic implications; however, none of them canindividually explain the whole concept of competitive advantage. Although competitive advantage is the coreissue of strategic management in which stakeholder management is rooted...

  13. 40 CFR 35.603 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.603 Section 35... (section 104(b)(3)) § 35.603 Competitive process. EPA will award water quality cooperative agreement funds through a competitive process in accordance with national program guidance. After the competitive...

  14. 40 CFR 35.382 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.382 Section 35...)(3)) § 35.382 Competitive process. State Wetlands Development Grants are awarded on a competitive... established by EPA. After the competitive process is complete, the recipient can, at its discretion,...

  15. Competitiveness in the CFA Franc Zone

    OpenAIRE

    Charalambos G. Tsangarides; Gustavo Ramirez

    2007-01-01

    This paper reviews the evolution of competitiveness in the CFA franc zone using a proposed comprehensive competitiveness framework. In particular, we examine competitiveness in the WAEMU and CEMAC regions by analyzing the "environment" and "policy" components of competitiveness and their quantifiable determinants, including indicators to measure productivity and labor market conditions, prices and costs, macroeconomic performance, business environment, governance, and technology and infrastru...

  16. Thailand : Country Development Partnership for Competitiveness

    OpenAIRE

    World Bank

    2001-01-01

    Competitiveness has emerged as a key issue confronting policymakers in Thailand. The Government's reform program will be extended by explicitly incorporating into the competitiveness framework measures that address the remaining constraints on competitiveness. The three critical areas that could constrain Thailand's medium term competitiveness include: 1) The need to strengthen the knowled...

  17. Business Plan Competitions: An Overview. CELCEE Digest.

    Science.gov (United States)

    Seymour, Nicole

    This document describes business plan competitions sponsored by universities. The idea began in the early 1980s at the University of Texas when Masters in Business Administration (MBA) students created a friendly competitive activity along the lines of the law schools Moot Court competition. Later the competition became national, and then…

  18. Political Globalization and the Competition State

    DEFF Research Database (Denmark)

    Pedersen, Ove K.

    2013-01-01

    Introduction to the concept of Competition State and descriptition of slow change from traditional welfare state towards the present competition state.......Introduction to the concept of Competition State and descriptition of slow change from traditional welfare state towards the present competition state....

  19. Fragment based discovery of Arginine isosteres through REPLACE: towards non-ATP competitive CDK inhibitors

    OpenAIRE

    Premnath, Padmavathy Nandha; Liu, Shu; Perkins, Tracy; Abbott, Jennifer; Anderson, Erin; McInnes, Campbell

    2013-01-01

    In order to develop non-ATP competitive CDK2/cyclin A inhibitors, the REPLACE strategy has been applied to generate fragment alternatives for the N-terminal tetrapeptide of the cyclin binding motif (HAKRRLIF) involved in substrate recruitment prior to phosphotransfer. The docking approach used for the prediction of small molecule mimics for peptide determinants was validated through reproduction of experimental binding modes of known inhibitors and provides useful information for evaluating b...

  20. Retail competition in electricity markets

    International Nuclear Information System (INIS)

    The introduction of competition into retail electricity supply gave rise to great expectations. However, to date, its performance has proven less than stellar, owing primarily to the theoretical concepts underpinning this reform, which draw heavily on the Austrian school. Neither consumers' decision processes nor this sector's technical paradigm were adequately accounted for, leading to an uncorrect estimation of the expected impact of opening to competition. Short- and medium-term prospects for the evolution of retail markets must be reconsidered from the perspective of greater stability: not a generalization of competition, but rather a persistent segmentation between active and inactive clients; not a large and rapid diffusion of radical innovations in commercialisation, with the potential for undermining the incumbents' positions

  1. Endogenous, Imperfectly Competitive Business Cycles

    DEFF Research Database (Denmark)

    Whitta-Jacobsen, Hans Jørgen

    below -½ (at stationary equilibrium). Market power on the labor markets may have the effect that imperfectly competitive cycles are in accordance with certain empirical regularities (some well known, some reported in the paper) concerning fluctuations in output and involuntary unemployment. Since......We investigate how imperfect competition affects the occurrence and the properties of endogenous, rational expectations business cycles in an overlapping generations model with constant returns to scale in production. The model has explicit product and labor markets all characterized by...... monopolistic competition. An implicit assumption of barriers to entry justifies that the number of firms is fixed even when positive profits occur. It turns out that both market power of firms on the product markets and market power of unions on the labor markets make the occurrence of cycles more likely. In...

  2. Retail competition in electricity markets

    International Nuclear Information System (INIS)

    The introduction of competition into retail electricity supply gave rise to great expectations. However, to date, its performance has proven less than stellar, owing primarily to the theoretical concepts underpinning this reform, which draw heavily on the Austrian school. Neither consumers' decision processes nor this sector's technical paradigm were adequately accounted for, leading to an uncorrect estimation of the expected impact of opening to competition. Short- and medium-term prospects for the evolution of retail markets must be reconsidered from the perspective of greater stability: not a generalization of competition, but rather a persistent segmentation between active and inactive clients; not a large and rapid diffusion of radical innovations in commercialisation, with the potential for undermining the incumbents' positions. (author)

  3. Different mechanisms are involved in the antibody mediated inhibition of ligand binding to the urokinase receptor

    DEFF Research Database (Denmark)

    List, K; Høyer-Hansen, G; Rønne, E;

    1999-01-01

    Certain monoclonal antibodies are capable of inhibiting the biological binding reactions of their target proteins. At the molecular level, this type of effect may be brought about by completely different mechanisms, such as competition for common binding determinants, steric hindrance or...

  4. Belowground competition among invading detritivores.

    Science.gov (United States)

    Chang, Chih-Han; Szlavecz, Katalin; Filley, Timothy; Buyer, Jeffrey S; Bernard, Michael J; Pitz, Scott L

    2016-01-01

    The factors regulating soil animal communities are poorly understood. Current theory favors niche complementarity and facilitation over competition as the primary forms of non-trophic interspecific interaction in soil fauna; however, competition has frequently been suggested as an important community-structuring factor in earthworms, ecosystem engineers that influence belowground processes. To date, direct evidence of competition in earthworms is lacking due to the difficulty inherent in identifying a limiting resource for saprophagous animals. In the present study, we offer the first direct evidence of interspecific competition for food in this dominant soil detritivore group by combining field observations with laboratory mesocosm experiments using 13C and 15N double-enriched leaf litter to track consumption patterns. In our experiments, the Asian invasive species Amynthas hilgendorfi was a dominant competitor for leaf litter against two European species currently invading the temperate deciduous forests in North America. This competitive advantage may account for recent invasion success of A. hilgendorfi in forests with established populations of European species, and we hypothesize that specific phenological differences play an important role in determining the outcome of the belowground competition. In contrast, Eisenoides lonnbergi, a common native species in the Eastern United States, occupied a unique trophic position with limited interactions with other species, which may contribute to its persistence in habitats dominated by invasive species. Furthermore, our results supported neither the hypothesis that facilitation occurs between species of different functional groups nor the hypothesis that species in the same group exhibit functional equivalency in C and N translocation in the soil. We propose that species identity is a more powerful approach to understand earthworm invasion and its impacts on belowground processes. PMID:27008785

  5. GLOBAL COMPETITIVENESS STRUCTURE OF TURKISH ECONOMY

    OpenAIRE

    TURGUTER, Yavuz

    2015-01-01

    Global competition conditions are sharpening and turning into more complex structure in the world economy. Under the highly competitive conditions, Turkish economy needs to increase her competitiveness against the closest competitors. In this context, main aim of this study is to investigate the competitiveness structure of Turkish economy by considering The Global Competitiveness Report of World Economic Forum. Main result of the study is that Turkish economy has to increase her competitiven...

  6. Competitiveness on the International Tourism Market

    OpenAIRE

    Anca Gabriela Turtureanu

    2012-01-01

    This paper comes to present and analyze the features of tourism in the main countries in Central and Western Europe, as well as the different strategies these countries adopt in order to maintain the competitiveness of the field. In the beginning, we have defined competitiveness, as the prerequisite of market success, we have analyzed its components and the main factors that determine it, as well as the competitivenesscompetitive advantage relation. During the last years, competitiveness h...

  7. THE IMPACT OF CORRUPTION ON NATIONAL COMPETITIVENESS

    OpenAIRE

    Mihaela Herciu

    2006-01-01

    The must uncorrupted nations are the mast competitive nations. The corruption – a very important phenomenon – is the one who make a nation to try to be competitive. In the last years the Nordic Country’s leading the top of competitiveness and the top of the uncorrupted nation. This article emphasizes the role of corruption in economic and social life with a strong impact on economic growth and competitiveness. The growth competitiveness index and the corruption perception index are the indica...

  8. Ireland’s Competitiveness Challenge 2014

    OpenAIRE

    2014-01-01

    Ireland’s Competitiveness Challenge 2014, which is produced under the Action Plan for Jobs 2014, outlines the National Competitiveness Council’s view of the main competitiveness issues confronting the business sector in Ireland over the medium term, and sets out a series of policy responses required to address these challenges. Building on their earlier benchmarking of Irish competitiveness, the Council focus on six major themes in the 2014 report: addressing cost competitiveness; broadening ...

  9. Tax Competition - Economic and Financial Policy Instruments

    OpenAIRE

    Daniela-Iuliana Radu

    2013-01-01

    Tax competition, both at European and international level, is a current research topic given the current context of accelerating globalization. Subject to competition and tax competition, is increasingly important in the European Union, characterized by a high degree of economic integration, the single currency and free movement of goods, services, people and capital. In this study we aim to achieve a separation of the concept of tax competition, tax competition and to outline its potential e...

  10. Ecological dumping under monopolistic competition

    International Nuclear Information System (INIS)

    The competitive choice of emission taxes by two governments is analysed in a model of monopolistic competition with capital mobility where pollution externalities are regional. Assuming that governments have no other policy instrument apart from emission taxes at their disposal, I show that governments choose inefficiently low (high) taxes if the importance of emissions in production is small (large) relative to transport costs and the mark-up. In contrast to the previous literature, the marginal disutility of pollution is not among the parameters which separate the non-cooperative choice of emission taxes from the social planner's choice

  11. The competitiveness of EU regions

    OpenAIRE

    Kourilova, Jana; Wokoun, Rene; Damborsky, Milan; Krejcova, Nikola

    2012-01-01

    The competitiveness of EU regions This paper results from the project financed by the Grant Agency of the Czech Republic (GA ÈR). The project was carried out by the research team consisting of both The Centre of Regional and Administrative Studies and The Regional Studies Department´s members in 2009 -2011. The introductory part of the paper is focused on the theoretical background with a special emphasis on the concept definition and determination of factors of the regional competitiveness....

  12. Specific binding of 3H-naloxone with isolated rat enterocytes

    International Nuclear Information System (INIS)

    This paper presents data on the specific binding of naloxone with isolated rat enterocytes. Naloxone was bound with the cells in medium 199 containing 1 mg/ml of BSA. The incubation mixture contained 5 x 100 mM 3H-naloxone and, if indicated, other substances also. Dose dependence of binding of naloxone with rat enterocytes is shown. The kinetics of specific binding of naloxone with enterocytes at different temperatures is also shown, as is the irreversibility of binding of 3H-naloxone with isolated rat enterocytes. It was found that different ligands of opioid receptors can inhibit binding of naloxone competitively

  13. Electric power's new competitive marketplace

    International Nuclear Information System (INIS)

    Currently, competition is limited primarily to power generation, the sale of wholesale bulk power, and fuel substitution at the point of end use. However, within the next several years, the rivalry will focus on large, energy-intensive industrial and large commercial customers. Driven by the disparity in rates among neighboring and regional utilities, large users are expected to lobby aggressively for retail wheeling and access to new supplies. New competitors will provide customers with additional supply options, forcing traditional utilities to offer better prices and or service. Competition at the point of end use also will increase as the natural gas industry develops new end-use technologies, gas utilities compete more aggressively, and some state regulatory commissions promote fuel switching as part of integrated resource planning (IRP) and demand-side management (DSM). However, as long as electric utilities are subject to cost-based rate of return regulation within price-sensitive markets, they will be a competitive disadvantage. The paper discusses the following: competitive risks by market segment, wholesale markets, industrial markets, commercial markets, residential markets, and franchise markets

  14. Market competition and efficient cooperation

    NARCIS (Netherlands)

    Brandts, J.; Riedl, A.M.

    2016-01-01

    We use laboratory experiments to study the causal effects of favorable and unfavorable competitive market experience on cooperation in a subsequent social dilemma game. The issues we study are part of the broader topic of whether there are behavioral spillovers between different spheres of social in

  15. Competitive edge of western coal

    International Nuclear Information System (INIS)

    This paper expresses views on the competitive advantages of one of the nation's most remarkable energy resources--Western coal. It covers utilization of Western coal, and its advantages. The Arkansas Power and Light Company and its demand for coal are also covered

  16. Castine wins international photography competition

    OpenAIRE

    Chadwick, Heather Riley

    2006-01-01

    Tim Castine, woodshop technician and photography instructor in the College of Architecture and Urban Studies at Virginia Tech, has been awarded the Best Black and White prize by the jurors of the 12th Annual American Institute of Architects Miami International Photography Competition.

  17. Nepal : Trade and Competitiveness Study

    OpenAIRE

    World Bank

    2003-01-01

    This study analyzes Nepal's trade policies and performance, identifies constraints to increasing trade competitiveness, and recommends policy changes and technical assistance to improve trade performance. The study is timely, as Nepal's interim Poverty Reduction Strategy Paper of 2003 assigns a key role to trade and exports as drivers of broad-based economic growth-one of the four main pil...

  18. Urban Competition and Urban Crisis

    DEFF Research Database (Denmark)

    Greve, Anni

    The essay gives a brief summery of Michel Foucault's 1978-1979 lectures which offers an important point of reference for a deeper understanding of the shift from liberal to neo-liberal ideas. Here he points out that neo-liberalism is an art of governemt that seeks to enforce competition. But his...

  19. Competitive economics of nuclear power

    International Nuclear Information System (INIS)

    Some 12 components of a valid study of the competitive economics of a newly ordered nuclear power plant are identified and explicated. These are then used to adjust the original cost projections of four authoritative studies of nuclear and coal power economics

  20. Rates for the competitive market

    International Nuclear Information System (INIS)

    The discussion panel consisted of Bruce Ander of Pamco Atlas, Ian Watson, Chair of the Ontario Chamber of Commerce Energy Committee, and Ken Snelson, Principal of Snelson International Energy. Ian Watson shared his membership's views on the future supply of electric power under a competitive energy system in Ontario, stressing the need for the government to instruct Ontario Hydro to bring forward a transmission rate to the Ontario Energy Board in 1997, and for legislation to allow independent buyers and sellers to contract with one another to use that transmission rate outside the control of Ontario Hydro. He also expressed concern about Ontario Hydro's anti-competitive load retention rate which was an obvious bid to retain its major customers. Ken Snelson reported on a review of the effects of competition on Canada's long-term energy outlook. He predicted that in a competitive market with full retail access, customers can expect a lot more choice; independent producers also will have many more options for selling power

  1. THE COMPETITIVENESS OF TEXTILE INDUSTRY

    Directory of Open Access Journals (Sweden)

    PRUNEA ANA

    2014-05-01

    Full Text Available The role of this paper is to highlight the position of the European players in the textile market and the challenges to which they are subjected. In this paper are presented ways, taking the „diamond" model of M. Porter and are adapted to the situation of the textile market. These adaptations have outlined the main existing problems and the possible solutions that can ensure the long-term competitive advantage. Gaining a competitive advantage based on innovation, the development of production and outsourcing strategies using the "diamond" model of M. Porter, we can say that is one of the viable solutions for gaining competitive advantages necessary for proper European companies to face competition from countries outside Europe. As developing countries do not meet certain environmental standards or norms of European law, but in terms of product innovation and development of new materials, they do not have the necessity for technology. We conducted an analysis of the factors that play a key role in the production of textiles, representing how they are used in the favor of European companies such investments to be supplemented can be found in how these factors act on the total costs.

  2. EU environmental policy and competitiveness

    Directory of Open Access Journals (Sweden)

    Stojanović Boban

    2006-01-01

    Full Text Available Protection of the environment was not a specific importance to the Community although the Treaty of Rome expressly specified that "health, safety environmental protection" shall be based on "a high level of protection". In deciding upon a framework for a European environmental policy, the Community was also responding to increased public awareness of the problem and concerns about the state of the natural and man-made environment. During the past years, competitiveness concerns have dominated the EU policy debate, in the course of which a growing consensus is being developed on the importance of eco-innovations and resource efficiency for EU competitiveness and on the market opportunities they offer. There is an increasing evidence that environmental policy and eco-innovations can promote economic growth, as well as maintain and create jobs, contributing both to competitiveness and employment. Environmental constraints to rapid economic growth are increasingly recognized by countries, leading to a rising awareness of the need for sustainable development. Implementation of an environmental policy however, generates significant implications for competition among countries.

  3. Competitive strategies in the NHS.

    Science.gov (United States)

    Coad, H; Kennedy, B

    1992-04-01

    The NHS has, of necessity since implementation of the NHS and Community Care Act 1990, strengthened its skills in business, marketing and other functions borrowed from industry and commerce. One area where, however, the NHS is currently weak is in competitive intelligence. Hazel Coad and Barbara Kennedy explain what this strategically important function is and how it can help financial viability. PMID:10118487

  4. Future survival requires competitive skills

    International Nuclear Information System (INIS)

    The companies that will succeed in the global power business in 25 years will be those that best understand the productivity implications of the current power game. In the competitive free market for electricity, the inefficient will be driven out. This will include the developer that is unable to achieve higher productivity in developing and financing projects, the engineer-constructor that longs for the old risk-free, cost-plus environment and the trading company that fails to enter into new relationships with the most productive companies in the world. Also in jeopardy will be the operator who can't reduce O and M costs and the manufacturer who is unable to control overhead or labor costs. Succeeding will be all about productivity. Free market competition drives productivity improvement. In a competitive environment, companies must operate at a more efficient level. The US learned this accidentally through the Public Utilities Regulatory Policies Act, getting us a side benefit of free market competition and lower electricity prices. In other countries the practice of socialism and its final bankruptcy forced adjustments to free market policies

  5. Credit rating dynamics and competition

    DEFF Research Database (Denmark)

    Hirth, Stefan

    2014-01-01

    I analyze the market for credit ratings with competition between more than two rating agencies. How can honest rating behavior be achieved, and under which conditions can a new honest rating agency successfully invade a market with inflating incumbents? My model predicts cyclic dynamics if...

  6. An Amusement Park Physics Competition

    Science.gov (United States)

    Moll, Rachel F.

    2010-01-01

    Amusement park physics is a popular way to reinforce physics concepts and to motivate physics learners. This article describes a novel physics competition where students use simple tools to take amusement park ride measurements and use the data to answer challenging exam questions. Research into the impact of participating in the competition…

  7. Global Energy Forecasting Competition 2012

    DEFF Research Database (Denmark)

    Hong, Tao; Pinson, Pierre; Fan, Shu

    2014-01-01

    The Global Energy Forecasting Competition (GEFCom2012) attracted hundreds of participants worldwide, who contributed many novel ideas to the energy forecasting field. This paper introduces both tracks of GEFCom2012, hierarchical load forecasting and wind power forecasting, with details on the...

  8. Multitasking, Competition and Provider Payment

    OpenAIRE

    Karen Eggleston

    2001-01-01

    Many important dimensions of quality health care are difficult to observe, monitor, and motivate. This paper examines how competition among providers interacts with payment system incentives when the allocation of provider effort among multiple such dimensions or ‘tasks’ is noncontractible. The framework highlights that an optimal provider payment system, including optimal risk adjustment, should take account of provider multitasking.

  9. Competition policy and market leaders

    Czech Academy of Sciences Publication Activity Database

    Maci, Ilir; Žigić, K.

    -, č. 375 (2008), s. 1-29. ISSN 1211-3298 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : competition policy * market leaders * innovation Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp375.pdf

  10. Competition policy and market leaders

    Czech Academy of Sciences Publication Activity Database

    Žigić, Krešimir; Maci, Ilir

    2011-01-01

    Roč. 28, č. 3 (2011), s. 1042-1049. ISSN 0264-9993 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : competition policy * innovation Subject RIV: AH - Economics Impact factor: 0.701, year: 2011

  11. Competition policy and market leaders

    Czech Academy of Sciences Publication Activity Database

    Maci, I.; Žigić, Krešimir

    -, č. 375 (2008), s. 1-29. ISSN 1211-3298 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : competition policy * market leaders * innovation Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp375.pdf

  12. Finite land resources and competition

    DEFF Research Database (Denmark)

    Haberl, Helmut; Mbow, Cheikh; Deng, Xiangzheng;

    2014-01-01

    their functions (objectives, distribution/ equity, effectiveness/efficiency). Analysis of long-term trajectories suggests that land-use competition is likely to intensify in the medium- to long-term future, mainly in the face of expected scarcities in resource supply (e.g., in terms of limited resources...

  13. "Project Psychology": A Classroom Competition

    Science.gov (United States)

    Fleck, Bethany K. B.; Hussey, Heather D.

    2009-01-01

    The authors describe an original and unique series of classroom group-work activities organized as a competitive game called "Project Psychology," which was implemented in an Introduction to Psychology course. The project goals included increasing student participation, interest, content comprehension, and motivation. Fostering connections to…

  14. Electricity competition and clean air

    International Nuclear Information System (INIS)

    The government of Ontario plans to establish a competitive market for the generation and sale of electricity by the year 2000, at which time Ontario Hydro will lose its monopoly. The government's rationale for moving to a competitive electricity market and the details of why this move could lead to a significant increase in air pollution was discussed. An overview of the health and environmental effects of electricity related air pollution was presented and the current national and provincial air quality objectives were outlined. The government of Ontario has promised that in implementing a competitive electricity market it will ensure that the province's environmental protection record is maintained and improved. It was suggested that in order to fulfill this commitment, new environmental regulations should be established to ensure that Ontario's total electricity-related emissions will decline when competition begins. Currently, air pollution from coal-fired power generating stations causes some of Ontario's most challenging health and environmental problems. Coal-fired generation stations are also major contributors to the build-up of greenhouse gases in the atmosphere. 74 refs., 2 tabs., 2 figs

  15. Media competition and electoral politics

    NARCIS (Netherlands)

    Piolatto, A.; Schütt, F.

    2015-01-01

    We build a framework linking competition in the media market to political participation. Media outlets report on the ability of candidates running for office and compete for audience through their choice of slant. Citizens consume news only if the expected utility of being informed about candidates'

  16. Media Competition and Electoral Politics

    NARCIS (Netherlands)

    Piolatto, A.; Schuett, F.

    2013-01-01

    Abstract: We build a framework linking competition in the media market to political participation, media slant, and selection of politicians. Media outlets report on the ability of candidates running for office and compete for audience through their choice of slant. Citizens derive utility from foll

  17. Competitive behaviour in supply chains

    Directory of Open Access Journals (Sweden)

    Sylwia Konecka

    2014-06-01

    Full Text Available Background: The article deals with the results of literature and empirical research into competitiveness and behaviour of entities in supply chains. Methods: A research hypothesis has been formulated that both partnership as well as dominance relations occur between enterprises functioning as suppliers-consignees. In order to verify the hypothesis a survey was completed in 2012. It encompassed 116 enterprises (manufacturers - 33, service providers - 32 and sellers - 24 as well as enterprises selling goods and providing services - 27 of which 54 were large, 26 medium and 36 were small enterprises. Competitive behaviour in supply chains has been identified and analysed. Furthermore, the authors intended to identify, reveal and examine possible interdependences between competitive behaviour and behaviour typical of supply chain strategies. Results and conclusions: The analysis of survey results revealed a tendency to preserve equilibrium between a chain leader and dependent enterprises. It may be easily justified in practice as on the one hand there is a need to keep the supply chain competitive and on the other hand to avoid the interruptions, which could occur as a result of elimination of dependent enterprises.

  18. PETROCHINA TOPS ASIAN COMPETITIVENESS RANKING

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    PetroChina, the largest oil producer in China, ranks first in a competitiveness report of listed Asian enterprises recently published by the Research Institute of Boao Forum for Asia. The oil giant tops the ranks in the Asian Competitiveness: Annual Repor

  19. The Africa Competitiveness Report 2015

    OpenAIRE

    World Economic Forum; World Bank; African Development Bank; Organisation for Economic Co-operation and Development

    2015-01-01

    The Africa Competitiveness Report 2015 comes out at a promising time for the continent: for 15 years growth rates have averaged over 5 percent, and rapid population growth holds the promise of a large emerging consumer market as well as an unprecedented labor force that - if leveraged - can provide significant growth opportunities. Moreover, the expansion of innovative business models, suc...

  20. Competitiveness of the mining sector

    International Nuclear Information System (INIS)

    The paper is based on the upgraded study of the evaluation of competitiveness of the Colombian mining sector, carried out for the UPME, in the year 2005, with base in this study, the conditions were examined offered for Colombia for the mining industry

  1. Natural gas prices and competitiveness

    International Nuclear Information System (INIS)

    The evolution of natural gas price in Hungary from 1992 to 1998 is discussed, in the framework of harmonization challenges for joining the European Union. The price trends are broken down by industrial, general and household usage. The Hungarian prices are compared with those in other European countries. The price strategy for market competitiveness is discussed. (R.P.)

  2. Sociophysics Simulations I: Language Competition

    OpenAIRE

    Schulze, Christian; Stauffer, Dietrich

    2005-01-01

    Using a bit-string model similar to biological simulations, the competition between different languages is simulated both without and with spatial structure. We compare our agent-based work with differential equations and the competing bit-string model of Kosmidis et al.

  3. Competition in a Social Structure

    Science.gov (United States)

    Legara, Erika Fille; Longjas, Anthony; Batac, Rene

    Complex adaptive agents develop strategies in the presence of competition. In modern human societies, there is an inherent sense of locality when describing inter-agent dynamics because of its network structure. One then wonders whether the traditional advertising schemes that are globally publicized and target random individuals are as effective in attracting a larger portion of the population as those that take advantage of local neighborhoods, such as "word-of-mouth" marketing schemes. Here, we demonstrate using a differential equation model that schemes targeting local cliques within the network are more successful at gaining a larger share of the population than those that target users randomly at a global scale (e.g., television commercials, print ads, etc.). This suggests that success in the competition is dependent not only on the number of individuals in the population but also on how they are connected in the network. We further show that the model is general in nature by considering examples of competition dynamics, particularly those of business competition and language death.

  4. Python bindings for libcloudph++

    OpenAIRE

    Jarecka, Dorota; Arabas, Sylwester; Del Vento, Davide

    2015-01-01

    This technical note introduces the Python bindings for libcloudph++. The libcloudph++ is a C++ library of algorithms for representing atmospheric cloud microphysics in numerical models. The bindings expose the complete functionality of the library to the Python users. The bindings are implemented using the Boost.Python C++ library and use NumPy arrays. This note includes listings with Python scripts exemplifying the use of selected library components. An example solution for using the Python ...

  5. The metal binding properties of kraft lignin

    OpenAIRE

    Waltersson, Johanna

    2009-01-01

    There is a strong driving force to increase the competitiveness of the pulping industry by finding new business opportunities. In this context full utilisation of the wood raw material used in conventional pulping mills is of vital importance. One focus area is to increase the utilisation areas of lignin. LignoBoost is a new method to obtain kraft lignin of high purity. The aim of the project was to investigate and increase the ability of LignoBoost kraft lignins to bind metals in aqueous sol...

  6. DNS & Bind Cookbook

    CERN Document Server

    Liu, Cricket

    2011-01-01

    The DNS & BIND Cookbook presents solutions to the many problems faced by network administrators responsible for a name server. Following O'Reilly's popular problem-and-solution cookbook format, this title is an indispensable companion to DNS & BIND, 4th Edition, the definitive guide to the critical task of name server administration. The cookbook contains dozens of code recipes showing solutions to everyday problems, ranging from simple questions, like, "How do I get BIND?" to more advanced topics like providing name service for IPv6 addresses. It's full of BIND configuration files that yo

  7. Python bindings for libcloudph++

    CERN Document Server

    Jarecka, Dorota; Del Vento, Davide

    2015-01-01

    This technical note introduces the Python bindings for libcloudph++. The libcloudph++ is a C++ library of algorithms for representing atmospheric cloud microphysics in numerical models. The bindings expose the complete functionality of the library to the Python users. The bindings are implemented using the Boost.Python C++ library and use NumPy arrays. This note includes listings with Python scripts exemplifying the use of selected library components. An example solution for using the Python bindings to access libcloudph++ from Fortran is presented.

  8. Management of competitiveness enterprise in modern terms

    Directory of Open Access Journals (Sweden)

    Serhii Spivak

    2014-05-01

    Full Text Available This paper discusses methodological approaches to assess the competitiveness of industrial enterprises on the basis of indicators to measure the production, finance, marketing potential, determination of the complex index of competitiveness. The problems of furniture manufacturing enterprises. The basic shortcomings of the industry in today's environment. The analysis of the competitiveness of furniture products on the market. Factors that influence the level of production and the mechanism of improving the competitiveness of enterprise management systems, including the implementation of the following steps: a the adoption of a fundamental decision by management on the feasibility competitiveness management; b formation of working groups; c analysis of the competitiveness of the furniture company, which is determined based on the competitiveness of certain furniture company; d management functional competitive furniture company; е evaluating the effectiveness of multi-use and implement actions organizational and economic mechanism of competitive.

  9. Bladder endothelin-1 receptor binding of bosentan and ambrisentan.

    Science.gov (United States)

    Osano, Ayaka; Yokoyama, Yoshinari; Hayashi, Hideki; Itoh, Kunihiko; Okura, Takashi; Deguchi, Yoshiharu; Ito, Yoshihiko; Yamada, Shizuo

    2014-01-01

    The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [(125)I]ET-1. The inhibition of specific [(125)I]ET-1 binding was measured in the presence of ET-1 and its receptor antagonists. Specific binding of [(125)I]ET-1 in rat bladder was saturable and of high affinity, which characterized selective labeling of bladder ET-1 receptors. ET-1, bosentan, ambrisentan, and CI-1020 inhibited specific [(125)I]ET-1 binding in a concentration-dependent manner at nanomolar ranges of IC50. Nonlinear least squares regression analysis revealed the presence of high- and low-affinity ET-1 receptor sites for ambrisentan and CI-1020. Bosentan and ambrisentan significantly increased the dissociation constant for bladder [(125)I]ET-1 binding without affecting maximal number of binding sites (Bmax). Thus, bosentan and ambrisentan seem to bind to bladder ET-1 receptor in a competitive and reversible manner. Oral administration of bosentan caused a dose-dependent decrease in Bmax for bladder [(125)I]ET-1 binding, suggesting significant binding of bladder ET-1 receptors in vivo. A significant amount of pharmacologically relevant ET-1 receptors may exist in the bladder. These receptors may be implicated in the pathogenesis of lower urinary tract symptoms and may also be promising targets for the development of therapeutic agents. PMID:24389822

  10. Competitive chemiluminescent anzyme immunoassay for vitamin B12 analysis in human milk.

    Science.gov (United States)

    Recent discoveries of matrix interferences by haptocorrin (HC) in human milk and serum show that past analyses of vitamin B12 in samples with high HC content might have been inaccurate (Lildballe et al., 2009; Carmel & Agrawal, 2012). We evaluated two competitive enzyme-binding immunoassays for seru...

  11. Measurement of tumour reactive antibody and antibody conjugate by competition, quantitated by flow cytofluorimetry.

    Science.gov (United States)

    Robins, R A; Laxton, R R; Garnett, M; Price, M R; Baldwin, R W

    1986-06-24

    Binding of unlabelled monoclonal antibody preparations has been assessed by competition at saturation with fluorochrome labelled homologous antibody for binding to antigen bearing target cells. The extent of competition was measured by quantitative flow cytofluorimetry, and simple mathematical procedures have been developed to allow the interpretation of competition data in terms of antibody binding activity. In the system studied, non-specific (non-competitive) fluorescence was minimal, but an iterative method to calculate its contribution to the measured signal is given. This approach has the advantage that the antibody preparation to be tested does not need to be labelled or modified; this is particularly important when evaluating the binding activity of therapeutic antibody conjugates. Comparison with a well characterized standard antibody preparation provides a rapid, sensitive and accurate quality control procedure. This test is also simple to perform, requiring only the mixing of labelled and unlabelled antibodies with target cells, a single incubation, followed by analysis without washing of the target cells. PMID:2424997

  12. CENTRAL AND EAST EUROPEAN COUNTRIES’ TOURISM COMPETITIVENESS AS A FACTOR OF THEIR NATIONAL COMPETITIVENESS LEVEL

    OpenAIRE

    Bojan KRSTIĆ; Sonja JOVANOVIC; Tanja STANISIC

    2014-01-01

    The purpose of this research is to analyze the contribution of travel and tourism competitiveness to the global competitiveness level of the Central and East Europe (CEE) countries. The aim is to identify the correlation between the achieved travel and tourism competitiveness level (measured by the Travel and Tourism Competitiveness Index) and national competitiveness level on the world list (measured by the Global Competitiveness Index) in the CEE countries. Structurally, the paper is compos...

  13. Designing competitions for education in robotics

    DEFF Research Database (Denmark)

    Andersen, Nils Axel; Ravn, Ole

    2012-01-01

    The paper describes design considerations for making a robot competition. Topics as level of participants, learning objective, evaluation form, task design and competition rules are treated. It is shown that careful design considering these topics are necessary for a succesful outcome of a compet......The paper describes design considerations for making a robot competition. Topics as level of participants, learning objective, evaluation form, task design and competition rules are treated. It is shown that careful design considering these topics are necessary for a succesful outcome...... of a competition. The conclusions are based on examples from more than 15 years of experience with robotic competitions....

  14. How competitive is nuclear energy?

    International Nuclear Information System (INIS)

    The economic competitiveness of nuclear energy will be crucial for determining its future share in world electricity production. In addition, the widespread liberalization of power markets, in particular in OECD countries, reinforces the role of commercial criteria in technology selection . The recently published IEA/NEA study on Projected Costs of Generating Electricity: 2010 Edition (IEA/NEA, 2010) provides important indications regarding the relative competitiveness of nuclear energy in OECD member countries as well as in four non-OECD countries (Brazil, China, Russia and South Africa). The results highlight the paramount importance of discount rates and, to a lesser extent, carbon and fuel prices when comparing different technologies. Going beyond this general finding, the study also shows that the relative competitiveness of nuclear energy varies widely from one major region to another, and even from country to country. While the study provides a useful snapshot of the costs of generating electricity with different technologies, it does not provide an absolute picture of the competitiveness of nuclear energy. Like any study, Projected Costs of Generating Electricity makes a number of common assumptions about discount rates as well as carbon and fuel prices. In addition, its calculations are based on a methodology that is referred to as the levelised cost of electricity (LCOE), which assumes that all risks are included in the interest or discount rate, which determines the cost of capital. In other words, neither the electricity price risk for nuclear and renewables, nor the carbon and fuel price risk for fossil fuels such as coal and gas, receive specific consideration. The decisions of private investors, however, will depend to a large extent on their individual appreciations of these risks. The competitiveness of nuclear energy thus depends on three different factors which may vary greatly from market to market: interest rates, carbon and fuel prices, and

  15. Demolishing the Competition: The Longitudinal Link between Competitive Video Games, Competitive Gambling, and Aggression

    Science.gov (United States)

    Adachi, Paul J. C.; Willoughby, Teena

    2013-01-01

    The majority of research on the link between video games and aggression has focused on the violent content in games. In contrast, recent experimental research suggests that it is video game competition, not violence, that has the greatest effect on aggression in the short-term. However, no researchers have examined the long-term relationship…

  16. Melanin-binding radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Packer, S; Fairchild, R G; Watts, K P; Greenberg, D; Hannon, S J

    1980-01-01

    The scope of this paper is limited to an analysis of the factors that are important to the relationship of radiopharmaceuticals to melanin. While the authors do not attempt to deal with differences between melanin-binding vs. melanoma-binding, a notable variance is assumed. (PSB)

  17. Melanin-binding radiopharmaceuticals

    International Nuclear Information System (INIS)

    The scope of this paper is limited to an analysis of the factors that are important to the relationship of radiopharmaceuticals to melanin. While the authors do not attempt to deal with differences between melanin-binding vs. melanoma-binding, a notable variance is assumed

  18. DNS BIND Server Configuration

    Directory of Open Access Journals (Sweden)

    Radu MARSANU

    2011-01-01

    Full Text Available After a brief presentation of the DNS and BIND standard for Unix platforms, the paper presents an application which has a principal objective, the configuring of the DNS BIND 9 server. The general objectives of the application are presented, follow by the description of the details of designing the program.

  19. Tension-induced binding of semiflexible biopolymers

    CERN Document Server

    Benetatos, Panayotis; Zippelius, Annette

    2014-01-01

    We investigate theoretically the effect of polymer tension on the collective behavior of reversibly binding cross-links. For this purpose, we employ a model of two weakly bending wormlike chains aligned in parallel by a tensile force, with a sequence of inter-chain binding sites regularly spaced along the contours. Reversible cross-links attach and detach at the sites with an affinity controlled by a chemical potential. In a mean-field approach, we calculate the free energy of the system and find the emergence of a free-energy barrier which controls the reversible (un)binding. The tension affects the conformational entropy of the chains which competes with the binding energy of the cross-links. This competition gives rise to a sudden increase in the fraction of bound sites as the tension increases. We show that this transition is related to the cross-over between weak and strong localization of a directed polymer in a pinning potential. The cross-over to the strongly bound state can be interpreted as a mechan...

  20. Oxytocin binding sites in bovine mammary tissue

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Xin.

    1989-01-01

    Oxytocin binding sites were identified and characterized in bovine mammary tissue. ({sup 3}H)-oxytocin binding reached equilibrium by 50 min at 20{degree}C and by 8 hr at 4{degree}C. The half-time of displacement at 20{degree}C was approximately 1 hr. Thyrotropin releasing hormone, adrenocorticotropin, angiotensin I, angiotensin II, pentagastrin, bradykinin, xenopsin and L-valyl-histidyl-L-leucyl-L-threonyl-L-prolyl-L-valyl-L-glutamyl-L-lysine were not competitive. In the presence of 10 nM LiCl, addition of oxytocin to dispersed bovine mammary cells, in which phosphatidylinositol was pre-labelled, caused a time and dose-dependent increase in radioactive inositiol monophosphate incorporation. The possibility that there are distinct vasopressin receptors in bovine mammary tissue was investigated. ({sup 3}H)-vasopressin binding reached equilibrium by 40 min at 20{degree}. The half-time of displacement at 20{degree}C was approximately 1 hr. The ability of the peptides to inhibit ({sup 3}H)-vasopressin binding was: (Thr{sup 4},Gly{sup 7})-oxytocin > Arg{sup 8}-vasopressin > (lys{sup 8})-vasopressin > (Deamino{sup 1},D-arg{sup 8})-vasopressin > oxytocin > d (CH{sub 2}){sub 5}Tyr(Me)AVP.

  1. Data for proteomic analysis of ATP-binding proteins and kinase inhibitor target proteins using an ATP probe

    OpenAIRE

    Jun Adachi; Marina Kishida; Shio Watanabe; Yuuki Hashimoto; Kazuna Fukamizu; Takeshi Tomonaga

    2015-01-01

    Interactions between ATP and ATP-binding proteins (ATPome) are common and are required for most cellular processes. Thus, it is clearly important to identify and quantify these interactions for understanding basic cellular mechanisms and the pathogenesis of various diseases. We used an ATP competition assay (competition between ATP and acyl-ATP probes) that enabled us to distinguish specific ATP-binding proteins from non-specific proteins (Adachi et al., 2014) [1]. As a result, we identified ...

  2. Intrapreneurship, Competition and Company Efficiency

    Directory of Open Access Journals (Sweden)

    Jože Kocjančič

    2013-01-01

    Full Text Available This paper investigates intrapreneurship, competition and company efficiencyin large Slovenian companies in order to provide firm-level evidenceand management implications on the extent to which companiesexploit available internal business potentials. The survey data for thesample of large Slovenian companies and statistical methodology areused to analyse the association between intrapreneurship, competitionand company efficiency. The empirical results confirmed the significantimpact of the internal business potentials on the operating results of theanalysed companies. The utilization rate of internal business potentialswas only partially or ill-used, reflecting the internal potential source ofunused business opportunities as one of possible ways to improve competitiveadvantage and company efficiency. The empirical results implythe importance of long-term managerial strategy towards innovationand encouraging creativity as the basis for successful internal corporatebusiness strategy to improve competitive advantage and company efficiency.

  3. BDS thin film damage competition

    Energy Technology Data Exchange (ETDEWEB)

    Stolz, C J; Thomas, M D; Griffin, A J

    2008-10-24

    A laser damage competition was held at the 2008 Boulder Damage Symposium in order to determine the current status of thin film laser resistance within the private, academic, and government sectors. This damage competition allows a direct comparison of the current state-of-the-art of high laser resistance coatings since they are all tested using the same damage test setup and the same protocol. A normal incidence high reflector multilayer coating was selected at a wavelength of 1064 nm. The substrates were provided by the submitters. A double blind test assured sample and submitter anonymity so only a summary of the results are presented here. In addition to the laser resistance results, details of deposition processes, coating materials, and layer count will also be shared.

  4. Plan competitions reveal entrepreneurial talent

    Energy Technology Data Exchange (ETDEWEB)

    Madison, Alison L.

    2011-05-15

    Monthly economic diversity column for Tri-City Herald business section. Excerpt below: There’s something to be said for gaining valuable real-world experience in a structured, nurturing environment. Take for instance learning to scuba dive in the comfort of my resort pool rather than immediately hanging out with sharks while I figure out little things like oxygen tanks and avoiding underwater panic attacks. Likewise, graduate students are getting some excellent, supportive real-world training through university business plan competitions. These competitions are places where smart minds, new technologies, months of preparation and coaching, and some healthy pre-presentation jitters collide to reveal not only solid new business ideas, but also some promising entrepreneurial talent. In fact, professionals from around our region descend upon college campuses every spring to judge these events, which help to bridge the gap between academics and the real technology and business-driven economy.

  5. Institutional Competitiveness in Media Markets

    DEFF Research Database (Denmark)

    Lund, Anker Brink

    a social science / leadership perspective - not from the perspective of a journalist or from the ideologically critical perspective of the license payer. Thirdly, we consider competition in the media market as an institutional phenomenon that is not solely conditioned by economic considerations. We aim......This inaugural address is a welcome opportunity to call your attention to a new area of research that the International Center for Business and Politics has chosen as one of five areas of special interest. By referring to this area of focus as'institutional competition in the media market' we also...... signal an approach that will be free of much of the traditional dogma in Danish media research: First of all, we will consider the media as a market for opinion, goods and services - not primarily as a cultural discourse with a singular focus on public service. Secondly, we consider media activity from...

  6. Neanderthal extinction by competitive exclusion.

    Directory of Open Access Journals (Sweden)

    William E Banks

    Full Text Available BACKGROUND: Despite a long history of investigation, considerable debate revolves around whether Neanderthals became extinct because of climate change or competition with anatomically modern humans (AMH. METHODOLOGY/PRINCIPAL FINDINGS: We apply a new methodology integrating archaeological and chronological data with high-resolution paleoclimatic simulations to define eco-cultural niches associated with Neanderthal and AMH adaptive systems during alternating cold and mild phases of Marine Isotope Stage 3. Our results indicate that Neanderthals and AMH exploited similar niches, and may have continued to do so in the absence of contact. CONCLUSIONS/SIGNIFICANCE: The southerly contraction of Neanderthal range in southwestern Europe during Greenland Interstadial 8 was not due to climate change or a change in adaptation, but rather concurrent AMH geographic expansion appears to have produced competition that led to Neanderthal extinction.

  7. Competitive Liner Shipping Network Design

    DEFF Research Database (Denmark)

    Karsten, Christian Vad

    shipping company earnings.The operation of the route net constitute the majority of the total costs, so it is essential to achieve a good capacity utilization in a route plan with travel times that satisfy customer requirements. Most academic articles dealing with the design of container networks neither...... quality.The contributions of this thesis cover modeling, methodology, and applications.The developed methods address operational (cargo routing), tactical (speed optimization and service selection), and strategic (network design) planning problems faced by liner shipping companies. Ultimately, the......The goal of this thesis is to develop decision support tools, which can be used to optimize container shipping networks while supporting competitive transportation services. The competitiveness of container liner shipping is to a high degree determined by transportation times and number of...

  8. Modeling competition between yeast strains

    Science.gov (United States)

    de Gee, Maarten; van Mourik, Hilda; de Visser, Arjan; Molenaar, Jaap

    2016-04-01

    We investigate toxin interference competition between S. cerevisiae colonies grown on a solid medium. In vivo experiments show that the outcome of this competition depends strongly on nutrient availability and cell densities. Here we present a new model for S. cerevisiae colonies, calculating the local height and composition of the colonies. The model simulates yeast colonies that show a good fit to experimental data. Simulations of colonies that start out with a homogeneous mixture of toxin producing and toxin sensitive cells can display remarkable pattern formation, depending on the initial ratio of the strains. Simulations in which the toxin producing and toxin sensitive species start at nearby positions clearly show that toxin production is advantageous.

  9. DXC'09 Industrial Track Competition Data

    Data.gov (United States)

    National Aeronautics and Space Administration — Competition data, including nominal and faulty scenarios, for Industrial Track Tier 1 and Tier 2 of the First International Diagnostic Competition. Three file...

  10. Developing Information Systems for Competitive Intelligence Support.

    Science.gov (United States)

    Hohhof, Bonnie

    1994-01-01

    Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

  11. Competitive Intelligence and the Information Center.

    Science.gov (United States)

    Greene, H. Frances

    1988-01-01

    Examines the competitive intelligence approach to corporate information gathering, and discusses how it differs from the traditional library information center approach. Steps for developing a competitive intelligence system in the library information center are suggested. (33 references) (MES)

  12. The political economy of competition in telecommunication

    DEFF Research Database (Denmark)

    Henten, Anders; Skouby, Knud Erik

    1998-01-01

    Article dealing with the regulation of telecommunications and the establishment of a competitive regime.......Article dealing with the regulation of telecommunications and the establishment of a competitive regime....

  13. Competitive pressures on income distribution in China

    NARCIS (Netherlands)

    Pan, H.

    1999-01-01

    to explore what perfect competition would do to income distribution in China. The research analyzes this question by determining personal income distribution under hypothetical, perfectly competitive conditions, where factors are rewarded according to their marginal productivities. Comparison with t

  14. SIAM 2007 Text Mining Competition dataset

    Data.gov (United States)

    National Aeronautics and Space Administration — Subject Area: Text Mining Description: This is the dataset used for the SIAM 2007 Text Mining competition. This competition focused on developing text mining...

  15. COMPETITIVENESS AND UNIT LABOUR COSTS IN ROMANIA

    OpenAIRE

    NAE TATIANA-ROXANA

    2009-01-01

    The present paper presents aspects related on Romanian competitiveness and its determination by unit labour cost (ULC). After reviewing the determinants of national competitiveness, it is taken into consideration the labour market as being an important de

  16. Competition in the sharing economy

    OpenAIRE

    Demary, Vera

    2015-01-01

    Sharing goods, services or knowledge is at the center of the so-called Sharing Economy. Businesses are usually based on online platforms that match demand and supply which is in many cases, but not always provided by individuals. Sharing Economy companies typically compete with traditional companies in many different markets. The main challenge of this type of competition currently is the application of the existing regulation. While incumbent firms adhere to this, Sharing Economy companies o...

  17. International Competitiveness in Wheat Production

    OpenAIRE

    Andersen, Jay C.; Condie, Frank A.

    1989-01-01

    The future competitiveness of U.S. wheat producers who have exported more than half their crop in recent years was analyzed. Trends in production and trade, and enterprise accounts and budgeting were used to assess the comparative costs of various competing U.S. and foreign producers. The future success of U.S. wheat producers is dependent on their own efficiency, government agricultural programs, weather, and many factors pertaining to general government policies. Relative currency values, s...

  18. Private benefits and market competition

    OpenAIRE

    Jacques Thépot

    2010-01-01

    This paper deals with corporate governance issues and competition policy. The impact of private benefits extraction on the values of oligopolistic firms is analyzed. Private benefits are assumed to generate costs which create price distortion on the product market. For a wide range of industry concentrations, we prove that this may affect the profit (i.e. the value) of the firms in a positive sense since the intensity of rivalry is reduced by the price distortion. Antitrust implications are d...

  19. Stackelberg competition with endogenous entry

    OpenAIRE

    Etro, F.

    2007-01-01

    This paper analyzes market structures where leaders have a first mover advantage and entry by the followers is endogenous. The strategy of the leaders is always more aggressive than the strategy of the followers independently from strategic substitutability or complementarity. Under quantity competition, the leader produces more than any other firm and I determine the conditions for entry deterrence to be optimal (high substitutability and constant or decreasing marginal costs). Under price c...

  20. Nepal: Trade and Competitiveness Study

    OpenAIRE

    Ahsan, Ahmad; Chapman, Ross

    2003-01-01

    This study analyzes Nepal's trade policies and performance, identifies constraints to increasing trade competitiveness, and recommends policy changes and technical assistance to improve trade performance. The study is timely, as Nepal's interim Poverty Reduction Strategy Paper of 2003 assigns a key role to trade and exports as drivers of broad-based economic growth-one of the four main pillars of its strategy. Key conclusions of this report suggest Nepal's trade policies are generally sound, ...

  1. Network Competition with Local Network

    OpenAIRE

    Oystein Fjeldstad; Moen, Espen R; Christian Riis

    2007-01-01

    Local network externalities are present when the network externalities associated with entering a certain network depends not only on the total number of agents in the network, but on the identity of the agents in the network. We explore the consequences of local network externalities within a framework where two networks compete on the Hotelling circle. We first show that local network externalities, in contrast to global network externalities, do not sharpen competition. Then we show that t...

  2. Building a Sustainable Competitive Advantage

    OpenAIRE

    Mukesh Srivastava; Andy Franklin; Louis Martinette

    2013-01-01

    This paper analyzes cross-industrial best practices and future trends in the context of the contemporary resource based competitive advantage model of the firm. It identifies key managerial levers, tools and systems that can be used to build and sustain a Hi-Technology company’s core competences in order to facilitate a more innovative, collaborative 21st century corporate culture. A qualitative and quantitative assessment is made of how a firm’s leadership, human capital management, organiza...

  3. Analysis and competitiveness in logistics

    OpenAIRE

    Eduard Dinu; Cristina Curea

    2008-01-01

    In the strategic analysis based on value chain concept, logistics represents main activities. Competing on the global market increase the importance of specific operations like transport of merchandise, warehouse exploitation, i.e. Creating and sustaining competitive advantage in the field of logistic activities is achievable through outsourcing or by in-house strategy. Choosing optimal ways to transport the merchandises, efficient warehouses design and utilization, adequate positioning oh th...

  4. Competition keeps SWU buyers happy

    International Nuclear Information System (INIS)

    While promising developments in laser separation for uranium enrichment have been realized and a group of utilities with centrifuge technology is exerting pressure on the US DoE to move into a more competitive position, projections of over-supply into the next century and questions about the economic viability for any enrichment venture allow room for a great deal of speculation about the future. (author)

  5. Monopolistic Competition: A Dual Approach

    OpenAIRE

    Paolo Bertoletti; Federico Etro

    2013-01-01

    We study monopolistic competition under indirect additivity of preferences. This is dual to the Dixit-Stiglitz model, where direct additivity is assumed, with the CES case as the only common ground. Other examples include (perceived) demand functions that are exponential or linear. Our equilibrium results are generally in contrast with those received by the literature. An increase of the number of consumers never affects prices and firms’ size, but increases proportionally the number of firms...

  6. Network Competition and Entry Deterrence

    OpenAIRE

    Calzada, Joan; Valletti, Tommaso

    2005-01-01

    We develop a model of logit demand that extends to a multi-firm industry the traditional duopoly framework of network competition with access charges. Firstly, we show that, when incumbents do not face the threat of entry and compete in prices, they inefficiently establish the reciprocal access charge below cost. This inefficiency disappears if incumbents compete in utilities instead of prices. Secondly, we study how incumbents change their choices under the threat of entry when they determin...

  7. Destination Competitiveness: Evidence from Bali

    OpenAIRE

    Chin, Wei Lee; Haddock-Fraser, Janet; Hampton, Mark P.

    2015-01-01

    Within the dynamic global tourism industry, understanding the reasons for a destination’s competitiveness is essential in order to enhance its performance, facilitate more effective destination management, and inform its overall sustainable economic development. This paper applies Kim and Wicks’ (2010) tourism cluster development model to Bali - a small, mature destination in the developing economy of Indonesia. It demonstrates that there are complex relationships between: (i) cluster actors;...

  8. Corporate behaviour and competitive forces

    OpenAIRE

    Bernard Paranque

    1995-01-01

    The purpose of this article is to propose a typology of the economic behaviour of French industrial companies in 1993 based on a sample of more than 7,000 companies participating in the Balance Sheet Data Centre of the Banque de France. The objective is therefore to explain how productivity and competitiveness shape a company's rate of return. Three performance levels have been put forward: the "physical" level, the "market" level and the "financial" level, corresponding respectively to labou...

  9. Climbing up the competitiveness ladder

    OpenAIRE

    Bartha, Zoltán

    2010-01-01

    The development strategy of most Central and Eastern European countries involves the boosting of foreign direct investments (FDI). Even greater emphases have been put on FDI with the unfolding of the global economic crisis, as the lack of local development resources have become ever more obvious. Country competitiveness indices were created to measure the general well-being of a country’s economy. It is generally believed that the best business environment is offered by countries scoring ...

  10. The Determinants of National Competitiveness

    OpenAIRE

    Mercedes Delgado; Christian Ketels; Porter, Michael E.; Scott Stern

    2012-01-01

    We define foundational competitiveness as the expected level of output per working-age individual that is supported by the overall quality of a country as a place to do business. The focus on output per potential worker, a broader measure of national productivity than output per current worker, reflects the dual role of workforce participation and output per worker in determining a nation's standard of living. Our framework highlights three broad and interrelated drivers of foundational compe...

  11. Interpersonal relations: Cooperation and competition

    OpenAIRE

    Schmitt, David R.

    1984-01-01

    Social relations between two persons require that consequences each receives depend at least in part on the responses of the other. Historically, research in several areas has focused on two contingencies, cooperation and competition, in which reinforcement is determined by the responses of both participants. A major research question in social psychology and applied behavior analysis has been: Which contingency is more effective with regard to the quantity or quality of some response? Althou...

  12. Income distribution and tax competition

    OpenAIRE

    Bjorvatn, Kjetil; Cappelen, Alexander W.

    2001-01-01

    The literature on international tax competition has shown how increased international mobility of the tax base may create a downward pressure on tax rates and give rise to increased inequality in disposable income. This paper endogenises the mobility of the tax base, explaining mobility as a function of the pre-tax income distribution. We show that increased pre-tax income inequality may reduce the ability of governments to carry out redistributive policies. Moreover, inc...

  13. Key issues in managed competition.

    OpenAIRE

    Shapiro, D W

    1994-01-01

    All managed competition proposals for health system reform must confront several key issues. The premiums paid to health care purchasing cooperatives will need to be subsidized for those who cannot pay full fare; the amount and sources of the subsidies are controversial political issues. The payments passed on by purchasing cooperatives to health plans must be risk adjusted to account for differences in the health care needs of their enrolled populations. This is essential to create a level p...

  14. Competitivity of biofuels in heating

    International Nuclear Information System (INIS)

    The competitivity of indigenous fuels in heating of residential houses in comparison with imported fuels, and both electricity and district heating, has been studied in this research, ordered by the Finnish Ministry of Trade and Industry. Heating plants of residential house scale (20-1000 kW) have been investigated in the research. Only the new heating plants are included in the investigation. The heat generation calculations concerning the residential heating plants have been made for following indigenous fuels: sod peat, fuel-chips, peat and wood pellets, firewood and straw. In addition to these, the calculations have been made for light fuel-oil, electric heating, district heating and natural gas. The local energy tariffs have to be taken into account in electric heating, district heating and natural gas heating. A calculation model, based on flowsheet calculation, forms the main result of the project. By using the model it is possible to update the competitivity data rapidly. Of all the indigenous fuels, sod peat and fuel-chips appeared to be competitive with electric and district heating costs in nearly all scales investigated. The construction of the heat generation costs of solid indigenous fuels differs remarkably from those of electric and district heating. The main part of the heating costs of wood chips and sod peat is formed of fixed costs; i.e. of investment costs and of the costs of heating and control work. The energy costs are the highest costs items in electric an district heating, as well as in the oil heating. It is possible to improve the competitivity of biofuels by developing cheaper boilers and fuel processing and storage devices

  15. Corruption and competition in procurement

    OpenAIRE

    Celentani, Marco; Ganuza, Juan J.

    2002-01-01

    We consider a procurement problem in which the procurement agent is supposed to allocate the realization of a project according to a competitive mechanism that values bids in terms of the proposed price and quality. Potential bidders have private information about their production costs. Since the procurement agent is also in charge of verifying delivered quality, in exchange for a bribe, he can allow an arbitrary firm to be awarded the realization of the project a...

  16. Functional aspects of competitive tennis

    OpenAIRE

    Torres Luque, Gema; Sánchez Pay, Alejandro; Bazaco Belmonte, María Jesús; Moya Ramón, Manuel

    2011-01-01

    Tennis is a sport that is characterized by intermittent dynamics, with intervallic moderate and high-intensity efforts due to repetitive actions of short-duration and high intensity. This review analyzes aspects such as the game's temporal structure, oxygen consumption, heart rate, lactate levels, and the effects of playing in heat. Knowledge of the contextual and functional characteristics of competitive tennis provides important information for improving the design of players training progr...

  17. Market competition and efficient cooperation

    OpenAIRE

    Brandts, J.; Riedl, A.M.

    2016-01-01

    We use laboratory experiments to study the causal effects of favorable and unfavorable competitive market experience on cooperation in a subsequent social dilemma game. The issues we study are part of the broader topic of whether there are behavioral spillovers between different spheres of social interactions. Market interaction takes place in a continuous double auction market in which one side of the market obtains the larger part of the surplus. We examine the efficiency of subsequent coop...

  18. The Reinforcement Learning Competition 2014

    OpenAIRE

    Dimitrakakis, Christos; Chalmers University of Technology; Li, Guangliang; University of Amsterdam; Tziortziotis, Nikoalos; University of Ioannina

    2014-01-01

    Reinforcement learning is one of the most general problems in artificial intelligence. It has been used to model problems in automated experiment design, control, economics, game playing, scheduling and telecommunications. The aim of the reinforcement learning competition is to encourage the development of very general learning agents for arbitrary reinforcement learning problems and to provide a test-bed for the unbiased evaluation of algorithms.

  19. Interest alignment and competitive advantage

    OpenAIRE

    Gottschalg, Oliver; Zollo, Mauricio

    2006-01-01

    This paper articulates a theory of the conditions under which the alignment between individual and collective interests generates sustainable competitive advantage. The theory is based on the influence of tacitness, context-specificity and casual ambiguity in the determinants of different types of motivation (extrinsic, normative intrinsic and hedonic intrinsic), under varying conditions of environmental dynamism. The analysis indicates the need to consider mitivational processes as a complem...

  20. International Competitiveness and Environmental Regulations

    OpenAIRE

    Babool, Md. Ashfaqul Islam; Michael R. Reed

    2005-01-01

    This study follows the standard factor endowment approach to explain the effects of environmental regulations on net exports in different product-based industries. It constructs an econometric model which includes factor endowments and environmental regulations to examine how strict environmental policy impact export competitiveness. Cross-sectional and time series (panel) data for 6 countries and 17 years were used in this model. In this study, capital services increase net exports in labor-...

  1. Screening, Competition, and Job Design

    OpenAIRE

    Bartling, Björn; Fehr, Ernst; Schmidt, Klaus

    2010-01-01

    In recent decades, many firms offered more discretion to their employees, often increasing the productivity of effort but also leaving more opportunities for shirking. These “high-performance work systems†are difficult to understand in terms of standard moral hazard models. We show experimentally that complementarities between high effort discretion, rent-sharing, screening opportunities, and competition are important driving forces behind these new forms of work organization. We document...

  2. Characterization of (/sup 3/H)paroxetine binding in rat brain

    Energy Technology Data Exchange (ETDEWEB)

    Marcusson, J.O.; Bergstroem, M.E.; Eriksson, K.; Ross, S.B.

    1988-06-01

    The binding of the 5-hydroxytryptamine (5-HT, serotonin) uptake inhibitor (3H)paroxetine to rat cortical homogenates has been characterized. The effect of tissue concentration was examined and, with 0.75 mg wet weight tissue/ml in a total volume of 1,600 microliter, the binding was optimized with an apparent dissociation constant (KD) of 0.03-0.05 nM. Competition experiments with 5-HT, citalopram, norzimeldine, and desipramine revealed a high (90%) proportion of displaceable binding that fitted a single-site binding model. Fluoxetine and imipramine revealed, in addition to a high-affinity (nanomolar) site, also a low-affinity (micromolar) site representing approximately 10% of the displaceable binding. The specificity of the (3H)paroxetine binding was emphasized by the fact that 5-HT was the only active neurotransmitter bound and that the serotonin S1 and S2 antagonist methysergide was without effect on the binding. Both 5-HT- and fluoxetine-sensitive (3H)paroxetine binding was completely abolished after protease treatment, suggesting that the binding site is of protein nature. Saturation studies with 5-HT (100 microM) sensitive (3H)paroxetine binding were also consistent with a single-site binding model, and the binding was competitively inhibited by 5-HT and imipramine. The number of binding sites (Bmax) for 5-HT-sensitive (3H)paroxetine and (3H)imipramine binding was the same, indicating that the radioligands bind to the same sites. Lesion experiments with p-chloroamphetamine resulted in a binding in frontal and parietal cortices becoming undetectable and a greater than 60% reduction in the striatum and hypothalamus, indicating a selective localization on 5-HT terminals. Together these findings suggest that (3H)paroxetine specifically and selectively labels the substrate recognition site for 5-HT uptake in rat brain.

  3. Revised article: Business Ideas Competition

    CERN Multimedia

    2003-01-01

    THIS ARTICLE REPLACES THAT PUBLISHED IN BULLETIN 27/2003, PAGE 8. "The Rainbow Seed Fund is a UK fund, which provides finance to support the commercialization of good ideas founded on scientific research; it is for the benefit of the UK industry in particular. To encourage ideas from CERN the Rainbow Seed Fund is running a business ideas competition. The winner of this competition will receive an immediate cash prize of GBP £1,000. In addition the Rainbow Seed Fund may well provide finance for market research, for protection of Intellectual Property Rights (IPR) and for prototyping to take the idea forward. Further awards of GBP £750 will be made for ideas which gain investment from the Fund. Candidates will only be required to prepare a 2-4-page summary of their business idea, and not a full business plan. Full details and an entry form are available at http://www.rainbowseedfund.com." ALL Members of the Personnel seeking participation in the business ideas competition are asked to submit their ideas via ...

  4. Competition in the electric industry

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Mel [NAC International, 655 Engineering Drive, Norcross, GA 30092 (United States)

    1998-07-01

    Deregulation of the electric power industry is changing the 'personality' of utilities and the way they operate in order to survive in a more competitive marketplace. This paper will identify and discuss key issues NAC International believes will arise as the nuclear industry responds to deregulation. The regulatory treatment of such issues as retail wheeling, recovery of stranded costs, divestiture of assets and securitization will have a significant impact on how utilities, particularly those with nuclear assets, proceed into the new marketplace. While some will survive as a result of innovative thinking, cost control, and entrance into new niche markets, others will be forced to reassess their viability altogether. Increased mergers and acquisitions and early plant closures are potential consequences of these struggles. Meanwhile, innovative companies will develop and enter into new nuclear markets including most notably the acquisition of generating assets. Other key drivers that will significantly impact the competitiveness of nuclear versus other fuels will be the resolution of the nuclear waste issue, the reduction of O and M and decisions regarding whether to make expensive capital additions. Additionally, this paper will present an overview of key regulatory and legislative initiatives impacting electricity. Finally, this paper will examine the roles of regulating bodies such as the Nuclear Regulatory Commission, Federal Energy Regulatory Commission, and state utility commissions, and will provide an outlook for further legislative and regulatory actions in this competitive environment. (author)

  5. Competition in the electric industry

    International Nuclear Information System (INIS)

    Deregulation of the electric power industry is changing the 'personality' of utilities and the way they operate in order to survive in a more competitive marketplace. This paper will identify and discuss key issues NAC International believes will arise as the nuclear industry responds to deregulation. The regulatory treatment of such issues as retail wheeling, recovery of stranded costs, divestiture of assets and securitization will have a significant impact on how utilities, particularly those with nuclear assets, proceed into the new marketplace. While some will survive as a result of innovative thinking, cost control, and entrance into new niche markets, others will be forced to reassess their viability altogether. Increased mergers and acquisitions and early plant closures are potential consequences of these struggles. Meanwhile, innovative companies will develop and enter into new nuclear markets including most notably the acquisition of generating assets. Other key drivers that will significantly impact the competitiveness of nuclear versus other fuels will be the resolution of the nuclear waste issue, the reduction of O and M and decisions regarding whether to make expensive capital additions. Additionally, this paper will present an overview of key regulatory and legislative initiatives impacting electricity. Finally, this paper will examine the roles of regulating bodies such as the Nuclear Regulatory Commission, Federal Energy Regulatory Commission, and state utility commissions, and will provide an outlook for further legislative and regulatory actions in this competitive environment. (author)

  6. Kinetic competition during glass formation

    International Nuclear Information System (INIS)

    Highlights: • The kinetics of glass formation has been elucidated in an Fe and Au-base alloy. • A critical cooling rate range should be considered for glass formation. • Wedge casting, calorimetry and upquenching data are used to model TTT curves. - Abstract: For vitrification of an alloy melt during cooling there is a kinetic competition with the nucleation and growth of metastable and stable crystalline phases. Many of the measures of glass forming ability (GFA) attempt to capture some of the features of the kinetic competition, but the GFA metrics are static measures and the kinetic processes are dynamic in nature. In fact, the critical cooling rate for glass formation should be viewed in terms of a critical cooling rate range to acknowledge the stochastic nature of crystal nucleation behavior. Direct measurements of the critical cooling rate range confirm this behavior and also provide useful input for kinetics analysis. Usually kinetics analyses are based upon crystallization behavior that is measured either isothermally or upon heating to temperatures near the crystallization onset, Tx and the results are extrapolated to much higher temperatures. This practice is based upon a number of assumptions about transport behavior in the undercooled liquid. With rapid up-quenching of amorphous samples, the high temperature crystallization behavior can be measured and used to refine the kinetics analysis and provide useful insight on the kinetic competition and glass forming ability

  7. Competition in public transport in Great Britain

    OpenAIRE

    White, Peter

    2006-01-01

    Britain offers a case in which much greater experience of competition in the public transport sector can be seen than in other European countries. Examples are drawn from this experience, showing that outcomes differ between the long-distance and local markets, price competition functioning much more effectively in the former. In many respects, the competitive bidding process may be seen as more important and extensive than direct ‘on the road’ inter-operator competition within th...

  8. Review: Competitive Learning Algorithm of Neural Network

    OpenAIRE

    Jithendra Singh Sengar; Niresh Sharma

    2011-01-01

    This paper deals mainly with the development of new learning algorithms and the study of the dynamics of neural networks. This survey paper will cover issues about the unsupervised competitive learning as well as some of its variances like hard competitive learning and soft competitive learning. After introducing of unsupervised learning algorithms, we will discuss the other competitive learning methods and motivations and goodness as well as the weakness of this model. Paper focuses on the e...

  9. Competition and Insurance Twenty Years Later

    OpenAIRE

    Michael Rothschild; Stiglitz, Joseph E

    1997-01-01

    We are honored to address the European Group of Risk and Insurance Economists and will take the opportunity to make some reflections on the rather uneasy relationship between insurance and competition.Economists generally prescribe competition as a solution for markets that do not work well. Competition allocates resources efficiently and encourages innovation and attention to what customers want. Insurance markets differ from most other markets because in insurance markets competition can de...

  10. Competition in the workplace: An experimental investigation

    OpenAIRE

    Benndorf, Volker; Rau, Holger A.

    2012-01-01

    We analyze competition between workers in a gift-exchange experiment where two workers are hired by the same employer. In the competition treatment the two employees simultaneously choose their effort whereas in the baseline treatment competition cannot occur since there is only one employee per employer. We find that in the competition treatment employers implicitly set tournament incentives by rewarding employees who choose higher effort levels than their co-workers. Here, employees' effort...

  11. Management of competitive intelligence in Latvia enterprises

    OpenAIRE

    Cekuls, Andrejs

    2012-01-01

    The Doctoral Theses are dedicated to analyzes of competitive intelligence management. The author works out the qualitative study and quantitative study, analysing the practice of competitive intelligence in Latvian enterprises. When analysing the study results, the author evaluates the competitive intelligence process in the business environment of Latvia, works out the competitive intelligence model at the large and medium Latvian enterprises, as well as on the basis of the study resul...

  12. Competitiveness of Belarus in world markets

    OpenAIRE

    Rybalka, Dzmitry

    2014-01-01

    This master thesis introduces the new approach to the measurement of Belarus'competitiveness. The topicality of this research is connected with absence of Belarus in the studies of the World Economic Forum and Institute for the Management Development. The author established the following goals while running the research: to analyze the existing concepts of national competitiveness, to define the essential factors of competitiveness, to examine such tool for measurement of national competitive...

  13. Identification and estimation of territorial competition

    OpenAIRE

    Sergey Grigor'evich Vazhenin; Irina Svyatoslavovna Vazhenina

    2012-01-01

    This paper formulates basic features of competition between the territories basing on the analysis of economic reality as well as on the basis of the sociological research conducted by the authors. The following components of the horizons of territorial competition in today's economic environment are identified and justified: — Competition between territories in the global economy is progressing significantly, it is expanding and improving itself; — The problem of competitive immu...

  14. Towards a universal definition of competitive intelligence

    OpenAIRE

    Rene Pellissier; Tshilidzi E. Nenzhelele

    2013-01-01

    Background: Enterprises face intense competition caused by globalisation. Consequently, enterprises look for tools that provide a competitive advantage. Competitive intelligence (CI) provides a competitive advantage to enterprises of all sizes. There are many definitions of CI but no universally accepted one.Objectives: The purpose of this research is to review the current literature on CI with the aim of identifying and analysing CI definitions to establish the commonalities and differences,...

  15. Competitive Intelligence in small and medium enterprises

    OpenAIRE

    Novák, Miroslav

    2011-01-01

    This thesis concentrates on Competitive Intelligence which is not well known in the Czech region. On the other hand, it has been a rapidly increasing discipline. The main aim of this thesis is to suggest how to use the methods of Competitive Intelligence in small and medium-sized companies. The theoretical part summarises the terminology of Competitive Intelligence. At first the strategic management is being defined, as it is the basis of practical usage of the Competitive Intelligence method...

  16. Global Markets and Time-Based Competition

    OpenAIRE

    Elisa Rancati

    2005-01-01

    Time becomes the benchmark that defines a company's strategic behaviour, extensively revamping the entire company by reinterpreting the time dimension in a different, extremely dynamic context. Marketing activities always presuppose time-based competition. From a marketing perspective, oriented to analysis of the competition, time-based competition can be defined as a strategy based on immediate response to the customer's needs. In the competitive conditions of over-supply, the time dimension...

  17. Review of the BCI Competition IV

    OpenAIRE

    MichaelTangermann; AdAertsen; NielsBirbaumer; ChristophBraun; ClemensBrunner; RobertLeeb; CarstenMehring; KaiJMiller; GuidoNolte; HubertPreissl; GerwinSchalk; AloisSchlögl; StephanWaldert

    2012-01-01

    The BCI Competition IV stands in the tradition of prior BCI Competitions that aim to provide high quality neuroscientific data for open access to the scientific community. As experienced already in prior competitions not only scientists from the narrow field of BCI compete, but scholars with a broad variety of backgrounds and nationalities. They include high specialists as well as students. The goals of all BCI Competitions have always been to challenge with respect to novel paradigms and co...

  18. DEVELOPING THE CONCEPT OF ENTERPRISE COMPETITIVENESS

    OpenAIRE

    Kalinichenko, L.

    2009-01-01

    The concept of “enterprise competitiveness" has been suggested, with a definition of its innovative and adaptive characteristics as the priority, and the concept has been substantiated of enterprise competitiveness, which is based on a systemic approach and includes the key building blocks of competitiveness, such as resource, management, and product competitive advantages, as well as the principles, tools, and criteria for evaluating its implementation.

  19. Theoretical Basis Of The Company Competitiveness Assessment

    OpenAIRE

    Vladimir Nikiforovich Belkin; Nadezhda Andreyevna Belkina; Larisa Borisovna Vladykina

    2015-01-01

    The article deals with the basic theoretical questions of the company competitiveness assessment. The state of modern economic thought on this issue is shown. The main factors of the company competitiveness are specified. A specific role of staff of an enterprise is revealed: on the one hand, it is a resource, on the other is a subject, resulting in productive movement all factors of competitiveness, i.e. the staff is a critical factor in the company competitiveness. The criterion of...

  20. Customer Relationship Management - Competitiveness Improvement Tool

    OpenAIRE

    Jovan Zubovic; Ivana Domazet

    2007-01-01

    On the global market competitiveness of Serbian companies is at a very low level. According to Global Competitiveness Report 2007-2008 Serbia was ranked 91. Leading country is USA, whereas the UK had lost the second and fell to ninth position. The criteria on which Global Competitiveness Report ranks 131 world countries are creation of business strategies and a quality of business environment1. Competitiveness increase of local companies’ should be assessed through holistic concept which targ...

  1. PARADIGMS REGARDING CONCERTED PRACTICES OF COMPETITION POLICY

    Directory of Open Access Journals (Sweden)

    Gabriela\tNEMŢOI

    2015-06-01

    Full Text Available The process of completing the single market requires the application of appropriate measures also in competition field. Rather, it is a truism that, once are removed the non-tariff barriers (physical, technical, fiscal of hindering trade, companies and governments will seek new ways to limit the restrictions so that competition laws to protect domestic industries. This study is a reflection on competitive practices regarding the theoretical and practical aspects in the phenomenon of economic competition.

  2. Logistics capabilities for sustainable competitive advantage

    OpenAIRE

    Sandberg, Erik; Abrahamsson, Mats

    2011-01-01

    The purpose of this paper is to explore how sustainable competitive advantage is generated in two Swedish best practice companies that successfully exploit logistics as a source for competitive advantage. Using a theoretical framework based on the resource-based view of the firm, this research elaborates on the links between operational and dynamic logistics capabilities and sustainable competitive advantage. The findings conclude that a sustainable competitive advantage is based on a combina...

  3. Competitiveness in the global economic crisis

    Directory of Open Access Journals (Sweden)

    Gheorghe Popescu

    2009-05-01

    Full Text Available The first challenge is to analyze the concept of "competitiveness" given the fact that in the centre of the great economic analystes' concerns lays from some time the phenomenon of competitiveness, along with the generation of competitive advantage at the organization level and, moreover, at country level. The economic science will have to be rethought, meaning that competitiveness will have to adapt to the new prospects launched today by the global economic crisis.

  4. Viewpoint: Canadian competition policy: progress and prospects

    OpenAIRE

    Thomas Ross

    2004-01-01

    This paper discusses the state of competition policy - in particular the economics of competition policy - in Canada today and considers its prospects going forward. It argues that: (i) the importance of competition policy has become accepted widely in Canada and indeed throughout much of the world; (ii) competition policy design and enforcement is in general well done in Canada; (iii) economists, including many Canadians, have played a central role in the development of an efficient and effe...

  5. Ireland's Competitiveness Scorecard 2011, July 2011

    OpenAIRE

    2011-01-01

    Each year the NCC publishes a report benchmarking Ireland's competitiveness performance. Ireland's Competitiveness Scorecard (previously named Benchmarking Ireland's Performance) analyses Ireland's overall competitiveness performance across a range of statistical indicators drawn from data sources such as Forfás, OECD, Eurostat, CSO and others.

  6. 40 CFR 35.712 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.712 Section 35... Monitoring (section 28) § 35.712 Competitive process. EPA will award Toxic Substances Control Act Compliance Monitoring grants to Tribes or Intertribal Consortia through a competitive process in accordance...

  7. 40 CFR 35.342 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.342 Section 35...) § 35.342 Competitive process. EPA Regions award Pollution Prevention State Grants to State programs through a competitive process in accordance with EPA guidance. When evaluating State applications,...

  8. 40 CFR 35.661 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.661 Section 35... 6605) § 35.661 Competitive process. EPA Regions award Pollution Prevention Grant funds to Tribes and Intertribal Consortia through a competitive process in accordance with EPA guidance. When evaluating a...

  9. 40 CFR 35.723 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.723 Section 35... Grants (pub.l. 105-276) § 35.723 Competitive process. EPA will award Tribal hazardous waste program... guidance. After the competitive process is complete, the recipient can, at its discretion, accept the...

  10. 40 CFR 35.362 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.362 Section 35... 104(b)(3)) § 35.362 Competitive process. EPA will award Water Quality Cooperative Agreement funds through a competitive process in accordance with national program guidance....

  11. 40 CFR 35.613 - Competitive process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.613 Section 35... (section 104(b)(3)) § 35.613 Competitive process. Wetlands development grants are awarded on a competitive... process is complete, the recipient can, at its discretion, accept the award as a wetlands...

  12. 78 FR 26404 - New Competitive Product

    Science.gov (United States)

    2013-05-06

    ... New Competitive Product AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission... 4 to the competitive product list. This notice informs the public of the filing, invites public... Return Service Contract 4 to the competitive product list.\\1\\ The Postal Service asserts that...

  13. 78 FR 20360 - New Competitive Product

    Science.gov (United States)

    2013-04-04

    ... New Competitive Product AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission... the competitive product list. This notice informs the public of the filing, invites public comment... Priority Mail Contract 56 to the competitive product list.\\1\\ The Postal Service asserts that Priority...

  14. 78 FR 20697 - New Competitive Product

    Science.gov (United States)

    2013-04-05

    ... New Competitive Product AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an addition to the competitive product list... 57 to the competitive product list.\\1\\ It asserts that Priority Mail Contract 57 is a...

  15. Exploring the Competitive Effects of Charter Schools

    Science.gov (United States)

    Carpenter, Dick M., II; Medina, Paul M.

    2011-01-01

    Central to the debate over school choice has been the question of how public schools respond to market-based competition. Many choice advocates suggest that competition can spur public schools to become more effective and efficient, but the evidence regarding the effect of competition from charters is comparably sparse and mixed. This article…

  16. 48 CFR 570.203-2 - Competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Competition. 570.203-2... 570.203-2 Competition. (a) Solicit at least three sources to promote competition to the maximum extent practicable. If you have repeated requirements for space in the same market, and if practicable, invite...

  17. How Banking Competition changed over Time

    NARCIS (Netherlands)

    Bikker, J.A.; Spierdijk, L.

    2008-01-01

    This paper is the first detailed and world-wide investigation of the developments in banking competition during the past fiffteen years. Using the Panzar-Rosse approach, we establish significant changes over time in the competitiveness of the banking industry. The changes in competition over time ar

  18. Methods to increase the competitiveness in industry

    OpenAIRE

    Ion STANCU; Lazarescu, Adriana

    2006-01-01

    Industrial firms are different between them for their economical characteristics, competitive situations and their prospects. Industry and competitive analysis use a lot of concepts and methods for obtaining a clear image concerning the variable conditions from industry and competitive strong forces. Economical characteristics of industry are important for their strategic implications.

  19. APPROPRIATION IN A COMPETITIVE THEORY OF VALUE

    OpenAIRE

    Louis Makowski; Joseph M. Ostroy

    2012-01-01

    Two perspectives on the price system are examined, as a method of valuation represented by Walrasian equilibrium and as a means of appropriation represented by “perfectly competitive equilibrium.” The stronger requirements of perfectly competitive equilibrium emphasize that valuation is driven by appropriation. Similarities between the full appropriation property of perfectly competitive equilibrium and efficient incentive compatible mechanism design are demonstrated.

  20. Competitiveness and linking of emission trading systems

    Energy Technology Data Exchange (ETDEWEB)

    Hausotter, Tobias; Steuwer, Sibyl; Taenzler, Dennis [adelphi, Berlin (Germany)

    2011-01-15

    The establishment of emission trading systems raises concerns among industries regarding international competitive disadvantages for the industries under an emissions cap. This study aims to assess competitiveness exposure of industrial sectors and presents policy measures to address these concerns. Moreover, the study provides a comparison of different existing approaches to competitiveness concerns proposed by regional emission trading systems. (orig.)

  1. Ireland’s Competitiveness Scorecard 2014

    OpenAIRE

    2014-01-01

    Ireland's Competitiveness Scorecard provides a comprehensive assessment of Ireland's competitiveness performance, using 120 statistical indicators. The indicators are drawn from data sources such as Forfás, OECD, Eurostat, CSO and others, and assess Ireland's international competitiveness in areas such as costs, productivity and innovation, labour market and skills, investment and infrastructure, the business environment and quality of life and sustainability.

  2. REGULATION AND ENFORCEMENT OF COMPETITION POLICY

    Directory of Open Access Journals (Sweden)

    Liviana Andreea Niminet

    2014-12-01

    Full Text Available Competition policy starts by shaping a legislative framework. This is aimed to establish boundaries for conducting competition and also sets limits of licit and illicit demarcation, for competitive and anticompetitive practices. The Romanian Competition Law has a divalent approach and it aims to provide specific behavioral conditions in order to stimulate and protect free-market competition, with the ultimate goal of developing a balanced, efficient and competitive economy. Our country’s Competition policy is based on punishing the behavior. There are three such types of anti-competitive behavior, namely: agreements between undertakings, abuse of dominant position and mergers and other concentrations between undertakings. Recent Practice proved that this “enforcement-conduct-punishment” structure is not necessary the best way to address competition and it is high time for authorities to switch both regulation and enforcement of competition from the “classical perspective” towards concepts like “competition advocacy” and “soft power” and give competition policy a new, reshaped face.

  3. Evolution of definition of competitiveness of products

    Directory of Open Access Journals (Sweden)

    I.A. Aleksandrov

    2010-12-01

    Full Text Available Investigational evolution of definition of competitiveness of products, certainly the stages of his development. Classification of existent approaches is improved in relation to the estimation of competitiveness of products, found out the sources of competitive edges from position of consumer cost, marginal utility, differentiation of products, demand and supply, key competense, marketing categories and ecological approach.

  4. Marketing research model of competitive environment

    Directory of Open Access Journals (Sweden)

    Krasilya Dmitriy

    2015-11-01

    Full Text Available To support its competitive advantages in current market conditions, each company needs to choose better ways of guaranteeing its favorable competitive position. In this regard, considerable interest lies in the structuring and algorithmization of marketing research processes that provide the information background of such choice. The article is devoted to modeling the process of marketing research of competitive environment.

  5. Structuring the competitive advantage of printing company

    OpenAIRE

    Kukharuk A. D.

    2013-01-01

    The nature of the concept of "competitive advantage of the company" if analyzed. The concept of "structuring a competitive advantage" is suggested. The model of structuring of printing company’s competitive advantage based on fundamentals of stakeholder theory is developed.

  6. Competition Policy in an Open Economy

    NARCIS (Netherlands)

    J.F. François (Joseph); H. Horn

    1998-01-01

    textabstractWe examine the setting of national competition policy in a two-country setting, emphasizing the relationship of trade to the goals of competition policy (such as the degree and nature of competition). The issues we address involve the general equilibrium distributional effects of competi

  7. Preliminary study of the metal binding site of an anti-DTPA-indium antibody by equilibrium binding immunoassays and immobilized metal ion affinity chromatography.

    Science.gov (United States)

    Boden, V; Colin, C; Barbet, J; Le Doussal, J M; Vijayalakshmi, M

    1995-01-01

    Creating metal coordination sites by modifying an existing enzyme or by eliciting antibodies against metal chelate haptens is of great interest in biotechnology to create enzyme catalysts with novel specificities. Here, we investigate the metal binding potential of a monoclonal antibody raised against a DTPA-In(III) hapten (mAb 734). We study its relative binding efficiency to metals of biological relevance by equilibrium binding immunoassays and immobilized metal ion affinity chromatography, two approaches which can give complementary information regarding composition and/or structure of the metal binding site(s). Fe(III), Fe(II), Cu(II), Mg(II), Ca(II), and Zn(II) binding was compared to In(III). All of them were shown to displace indium, but their affinity for mAb 734 decreased by 100-fold compared to indium. Competitive metal binding immunoassays between Zn(II) and In(III) revealed an unusual behavior by Zn(II) which remains to be explained. Moreover, IMAC allowed us to predict the metal binding amino acids involved in the antibody paratope. The antibody metal binding site was shown to contain at least two histidine residues in a cluster, and the presence of aspartic and glutamic acid as well as cysteine residues could not be excluded. Thus, simple competition studies allows us to obtain some partial information on the metal binding structural features of this anti-metal chelate antibody and to guide our screening of its catalytic potential. PMID:7578356

  8. The serotonin transporter: Examination of the changes in transporter affinity induced by ligand binding

    International Nuclear Information System (INIS)

    The plasmalemmal serotonin transporter uses transmembrane gradients of Na+, Cl- and K+ to accumulate serotonin within blood platelets. Transport is competitively inhibited by the antidepressant imipramine. Like serotonin transport, imipramine binding requires Na+. Unlike serotonin, however, imipramine does not appear to be transported. To gain insight into the mechanism of serotonin transport the author have analyzed the influences of Na+ and Cl-, the two ions cotransported with serotonin, on both serotonin transport and the interaction of imipramine and other antidepressant drugs with the plasmalemmal serotonin transporter of human platelets. Additionally, the author have synthesized, purified and characterized the binding of 2-iodoimipramine to the serotonin transporter. Finally, the author have conducted a preliminary study of the inhibition of serotonin transport and imipramine binding produced by dicyclohexylcarbodiimide. My results reveal many instances of positive heterotropic cooperativity in ligand binding to the serotonin transporter. Na+ binding enhances the transporters affinity for imipramine and several other antidepressant drugs, and also increases the affinity for Cl-. Cl- enhances the transporters affinity for imipramine, as well as for Na+. At concentrations in the range of its KM for transport serotonin is a competitive inhibitor of imipramine binding. At much higher concentrations, however, serotonin also inhibits imipramines dissociation rate constant. This latter effect which is Na+-independent and species specific, is apparently produced by serotonin binding at a second, low affinity site on, or near, the transporter complex. Iodoimipramine competitively inhibit both [3H]imipramine binding and [3H]serotonin transport

  9. "Wanna Race?": Primary Student Preference for Competitive or Non-Competitive Singing Games

    Science.gov (United States)

    Roberts, J. Christopher

    2016-01-01

    This study compared primary student preference for competitive and non-competitive singing games. Students in three intact classes of second graders (n = 65) and three classes of fourth graders (n = 67) at one school in the USA served as subjects. After playing a pair of games, one competitive and one non-competitive, over the course of five…

  10. A New Competitive Adsorption Isothermal Model of Heavy Metals in Soils

    Institute of Scientific and Technical Information of China (English)

    XUE Wen-Bo; YI Ai-Hua; ZHANG Zeng-Qiang; TANG Ci-Lai; ZHANG Xing-Chang; GAO Jin-Ming

    2009-01-01

    A new competitive adsorption isothermal model (CAIM) was developed for the coexistent and competitive binding of heavy metals to the soil surface.This model extended the earlier adsorption isothermal models by considering more than one kind of ion adsorption on the soil surface.It was compared with the Langmuir model using different conditions,and it was found that CAIM,which was suitable for competitive ion adsorption at the soil solid-liquid surface,had more advantages than the Langmuir model.The new competitive adsorption isothermal model was used to fit the data of heavy metal (Zn and Cd) competitive adsorption by a yellow soil at two temperatures.The results showed that CAIM was appropriate for the competitive adsorption of heavy metals on the soil surface at different temperatures.The fitted parameters of CAIM had explicit physical meaning.The model allowed for the calculation of the standard molar Gibbs free energy change,the standard molar enthalpy change,and the standard molar entropy change of the competitive adsorption of the heavy metals,Zn and Cd,by the yellow soil at two temperatures using the thermodynamic equilibrium constants.

  11. The Literature Review of a New Form of Competitiveness Called City Competitiveness

    Directory of Open Access Journals (Sweden)

    Osman EROĞLU

    2014-06-01

    Full Text Available With globalization, the rapid development of information technologies and the rapid changes in the economic structure, the country’s borders at a time increasingly depreciate and the importance of city competitiveness reveals. Although it is an ongoing debate around the world whether cities compete with each other, city competitiveness is a new form of competitiveness. Cities compete with each other to increase their competitiveness. City competitiveness is defined as having better values compared to other cities. In this study, a new form of competitiveness called city competitiveness is examined.

  12. Entropy and Equilibria in Competitive Systems

    Directory of Open Access Journals (Sweden)

    A. Y. Klimenko

    2013-12-01

    Full Text Available This paper investigates the applicability of thermodynamic concepts and principles to competitive systems. We show that Tsallis entropies are suitable for the characterisation of systems with transitive competition when mutations deviate from Gibbs mutations. Different types of equilibria in competitive systems are considered and analysed. As competition rules become more and more intransitive, thermodynamic analogies are eroded, and the behaviour of the system can become complex. This work analyses the phenomenon of punctuated evolution in the context of the competitive risk/benefit dilemma.

  13. Model Selection in Data Analysis Competitions

    DEFF Research Database (Denmark)

    Wind, David Kofoed; Winther, Ole

    2014-01-01

    The use of data analysis competitions for selecting the most appropriate model for a problem is a recent innovation in the field of predictive machine learning. Two of the most well-known examples of this trend was the Netflix Competition and recently the competitions hosted on the online platform...... Kaggle. In this paper, we will state and try to verify a set of qualitative hypotheses about predictive modelling, both in general and in the scope of data analysis competitions. To verify our hypotheses we will look at previous competitions and their outcomes, use qualitative interviews with top...

  14. Competition in Healthcare: Good, Bad or Ugly?

    Directory of Open Access Journals (Sweden)

    Maria Goddard

    2015-09-01

    Full Text Available The role of competition in healthcare is much debated. Despite a wealth of international experience in relation to competition, evidence is mixed and contested and the debate about the potential role for competition is often polarised. This paper considers briefly some of the reasons for this, focusing on what is meant by “competition in healthcare” and why it is more valuable to think about the circumstances in which competition is more and less likely to be a good tool to achieve benefits, rather than whether or not it is “good” or “bad,” per se.

  15. SHBG (Sex Hormone Binding Globulin)

    Science.gov (United States)

    ... as: Testosterone-estrogen Binding Globulin; TeBG Formal name: Sex Hormone Binding Globulin Related tests: Testosterone , Free Testosterone, ... I should know? How is it used? The sex hormone binding globulin (SHBG) test may be used ...

  16. Theoretical Basis Of The Company Competitiveness Assessment

    Directory of Open Access Journals (Sweden)

    Vladimir Nikiforovich Belkin

    2015-03-01

    Full Text Available The article deals with the basic theoretical questions of the company competitiveness assessment. The state of modern economic thought on this issue is shown. The main factors of the company competitiveness are specified. A specific role of staff of an enterprise is revealed: on the one hand, it is a resource, on the other is a subject, resulting in productive movement all factors of competitiveness, i.e. the staff is a critical factor in the company competitiveness. The criterion of company competitiveness is proposed, on its basis, the concept of “competitive enterprise” is defined. The most well-known approaches for assessing the company competitiveness are analyzed. The author’s method of the company competitiveness assessment based on the dynamics of the integral index of competitiveness is provided. For those cases, when it is impossible to determine the proportion of products on the market, it is proposed to evaluate the company competitiveness on the profitability of its production. The article shows the experience in calculating of the company competitiveness on the proposed author’s methods.

  17. Export competitiveness of pakistani horticultural products

    International Nuclear Information System (INIS)

    This paper examines Pakistan's competitiveness in export of selected horticulture commodities by employing set of revealed comparative advantage (RCA) and revealed competitive advantage indices with respect to global trade. Results demonstrate that Pakistan has comparative and competitive advantage over the period under analysis and indicates a transition from comparative and competitive disadvantage to comparative and competitive advantage during the period under analysis. Tangerines, mandarins, clem have maintained relatively higher revealed comparative advantage as compared to other categories for the whole period under analysis. Onion export has revealed comparative advantage with some fluctuations over time. The research indicates that Pakistan's comparative and competitive advantages have been increasing in all the selected commodities during period under analysis which indicates the potential of horticulture exports for foreign exchange earnings. There is need to strengthen comparative and competitive advantage in horticulture sector by policy support and facilitating role by all stakeholders. (author)

  18. A Neural Network Model for the Correlation between Sprinters’ Pre-competition Anxiety and Competition Performance

    OpenAIRE

    Jiwei Yao; Yongliang Yang; Xiang Xie; Wenxin Xu; Xiushi Ding

    2013-01-01

    Sprint is an important sporting event in track and field competition, in which, athletes’ pre-competition anxiety will greatly affect them in bringing into play their competence, which will then influence their final performance in the competition. For this reason, to study the correlation between sprinters’ pre-competition anxiety and their competition performance is of great significance in predicting athletes’ performance under difference anxiety state. After having analyzed domestic and f...

  19. A Conceptual Mapping Resource Advantage Theory, Competitive Advantage Theory, and Transient Competitive Advantage

    Directory of Open Access Journals (Sweden)

    Jasanta PERANGINANGIN

    2015-09-01

    Full Text Available Competitive advantage is the main purposed of the business entity focusing on market base view. Resource advantage theorists put their concern to empowering resources development with resources based view, in the other side needs to redefining competitive advantage. All the competitive advantage are transient, concluded the end of competitive advantage. Redefining competitive advantage by selling migration and shrewdness outward. This research to emphasize innovation capability rarely appears in the future.

  20. A Conceptual Mapping Resource Advantage Theory, Competitive Advantage Theory, and Transient Competitive Advantage

    OpenAIRE

    Jasanta PERANGINANGIN

    2015-01-01

    Competitive advantage is the main purposed of the business entity focusing on market base view. Resource advantage theorists put their concern to empowering resources development with resources based view, in the other side needs to redefining competitive advantage. All the competitive advantage are transient, concluded the end of competitive advantage. Redefining competitive advantage by selling migration and shrewdness outward. This research to emphasize innovation capability rarely appears...

  1. TRANSITION COUNTRIES TOWARDS INTERNATIONAL COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Gazmend Qorraj

    2013-12-01

    Full Text Available Most of the transition countries in Europe had significant benefits from the EU enlargement but the positive effects depend also from the structure of the economy and reforms of these countries. It’s important to analyze: if transition countries ensured sustainable economic reforms or just short term stability and emergent solutions. This paper will address international competitiveness which is the main challenge for the transition countries but also for the EU. First, monopoly position of some international firms in local markets and lack of creativity and innovations of the local firms, especially in Western Balkans due to lack of institutional support and non-stable business environment. The problem of creativity and lack of innovations by the firms is also a serious issue for the EU countries. The second important issue is large productivity gap. The recent global financial crisis as well as EU crises present the difficulties in the Euro zone and highlighted the interdependence of national economies and the convergence problems within European Union. The third challenge is absorption capacity for the structural and cohesion funds. The past experience of Central European countries shows that success in effectively using the EU financial and technical assistance is positively related with the success of countries on creating sustainable economic development and international competitiveness. Fourth issue is that some transition countries achieved economic growth but due to unequal distribution of welfare on these countries there is no significant reduce of unemployment and social cohesion. Last but not least the international competitiveness in most of the countries is harmed by the lack of functional institutions due to high level of corruption, inefficiency, rule of law, the lack of transparency and accountability.

  2. Nursing: the hospital's competitive edge.

    Science.gov (United States)

    Shaffer, F A; Preziosi, P

    1988-09-01

    The health care marketplace is becoming increasingly competitive. The hospital has a built-in marketing force with the nursing department, because nurses are in constant, direct contact with the customer. Nursing must identify the case mix profile of the community and focus the hospital product lines to meet community needs. The nursing department should decentralize, change, measure, and innovate the staff mix needed to operationalize these product lines. The development of nursing practice standards for the case mix will help to identify the staff mix needed and create systems to efficiently manage the product lines. Nursing management must become aware of cross-subsidization and downward skill substitution of nursing personnel. Nursing information systems must generate quality reports that invoke cost consciousness on the part of nursing staff. Quality assurance programs must become unit based and complete with frequent audits to correlate length of stay with nursing quality. Correlations must be determined between nursing productivity and case mix to determine the hospital's niche in the marketplace. The transformation of health care into a competitive business industry has created many opportunities for nursing. The health care industry's incentives for efficiency along with the decreasing demand for inpatient hospital services will be the forces driving health care toward a competitive marketplace. The hospital's nursing department should be strategically positioned to become accountable for increasing market share and enhancing quality patient outcomes. The focus has shifted from the theoretical to the tactical, which is a step in the right direction, particularly for nursing. Nursing, if strategically positioned, will not only thrive but will also excel in this chaotic environment by capturing the opportunities and being innovative. PMID:3047695

  3. Fragment based discovery of Arginine isosteres through REPLACE: towards non-ATP competitive CDK inhibitors

    Science.gov (United States)

    Premnath, Padmavathy Nandha; Liu, Shu; Perkins, Tracy; Abbott, Jennifer; Anderson, Erin; McInnes, Campbell

    2013-01-01

    In order to develop non-ATP competitive CDK2/cyclin A inhibitors, the REPLACE strategy has been applied to generate fragment alternatives for the N-terminal tetrapeptide of the cyclin binding motif (HAKRRLIF) involved in substrate recruitment prior to phosphotransfer. The docking approach used for the prediction of small molecule mimics for peptide determinants was validated through reproduction of experimental binding modes of known inhibitors and provides useful information for evaluating binding to protein-protein interaction sites. Further to this, potential arginine isosteres predicted using the validated LigandFit docking method were ligated to the truncated C-terminal peptide, RLIF using solid phase synthesis and evaluated in a competitive binding assay. After testing, identified fragments were shown to represent not only appropriate mimics for a critical arginine residue but also to interact effectively with a minor hydrophobic pocket present in the binding groove. Further evaluation of binding modes was undertaken to optimize the potency of these compounds. Through further application of the REPLACE strategy in this study, peptide-small molecule hybrid CDK2 inhibitors were identified that are more drug-like and suitable for further optimization as anti-tumor therapeutics. PMID:24286762

  4. Banking Competition and Economic Stability

    OpenAIRE

    Ronald Fischer; Nicolás Inostroza; Felipe J. Ramírez

    2013-01-01

    We consider a two-period model of a banking system to explore the effects of competition on the stability and efficiency of economic activity. In the model, competing banks lend to entrepreneurs. After entrepreneurs receive the loans for their projects, there is a probability of a shock. The shock implies that a fraction of firms will default and be unable to pay back their loans. This will require banks to use their capital and reserves to pay back depositors, restricting restrict second per...

  5. Parity and Predictability of Competitions

    CERN Document Server

    Ben-Naim, E; Vázquez, F

    2006-01-01

    We present an extensive statistical analysis of the results of all sports competitions in five major sports leagues in England and the United States. We characterize the parity among teams by the variance in the winning fraction from season-end standings data and quantify the predictability of games by the frequency of upsets from game results data. We introduce a novel mathematical model in which the underdog team wins with a fixed upset probability. This model quantitatively relates the parity among teams with the predictability of the games, and it can be used to estimate the upset frequency from standings data.

  6. Presentation at Innoventure Annual Competition

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-03-31

    This report documents the components of the workshop presented at the recent annual competition for the Innoventure program. The goal of the workshop was to focus on the delivery of science, technology, engineering, and math (STEM) concepts in a hands-on experiential learning format to increase interest in national security careers at NNSA, most of which are in the STEM fields. This work is a part of the National Security Preparedness Project (NSPP), being performed under a Department of Energy (DOE)/National Nuclear Security Administration (NNSA) grant.

  7. Competitive Intelligence and Internet Sources

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available In the Knowledge Age to maintain profitability and in some cases to remain in the market, companies must focus their actions in activities such as collecting, filtering, and disseminating information about market, about competitors and their actions. Those are part of Competitive Intelligence (CI concept. In digital age, most of the information needed for CI projects is available on the web. This paper focuses on this field and presents a mix of directions that companies need to take into consideration in their CI projects in order to achieve the goals.

  8. Competitive Think Tanks in Europe

    DEFF Research Database (Denmark)

    Kelstrup, Jesper Dahl

    view that changing policy environments results in convergence of think tank strategies across Europe. As a perspective the paper shows that competitive think tanks do have a high average impact pr. staff on both mass and new media compared to other types of think tanks. This may indicate that......This paper offers a model for understanding the strategies that think tanks use to influence policy-making. The model combines the concepts of policy environments (McGann and Weaver, 2000) and knowledge regimes (Campbell and Pedersen, 2011) and argues that think tank strategies reflect changes in...

  9. Competitive Brand Salience

    OpenAIRE

    Ralf van der Lans; Rik Pieters; Michel Wedel

    2008-01-01

    Brand salience—the extent to which a brand visually stands out from its competitors—is vital in competing on the shelf, yet is not easy to achieve in practice. This study proposes a methodology to determine the competitive salience of brands, based on a model of visual search and eye-movement recordings collected during a brand search experiment. We estimate brand salience at the point of purchase, based on perceptual features (color, luminance, edges) and how these are influenced by consumer...

  10. Transforming for a competitive environment

    International Nuclear Information System (INIS)

    The essential elements for successful strategic marketing of electricity in the future were discussed. The elements emphasized included understanding the industry restructuring, developing appropriate business and marketing strategies, and confronting transformation challenges. How these elements are being addressed by Central Vermont, the public utility serving customers in Vermont and in New Hampshire, was described. A customer oriented culture, a flexible organization that encourages innovation, a clear marketing strategy based on the company's core competencies, a new business/product development process, strategic alliances, and a sharp eye for what the competition is doing, were considered the most important and most urgent tasks to tackle in order to ensure survival and success

  11. 2005 Solar Decathlon (Competition Program)

    Energy Technology Data Exchange (ETDEWEB)

    2005-10-01

    The 2005 Solar Decathlon Competition Program is distributed to Solar Decathlon visitors, media, sponsors, and the student competitors. It contains basic facts about the Solar Decathlon: what, where, when, who, and how. It is a guide for visitors to the events and workshops. It describes the 10 contests and the technologies used in the houses. It celebrates the accomplishments of the competitors and provides an opportunity for the major sponsors to describe their roles and relay their commitment to the ideals of the Solar Decathlon.

  12. [Penicillin-binding proteins of various strains of Lactobacillus].

    Science.gov (United States)

    Griaznova, N S; Subbotina, N A; Beliavskaia, I V; Taisova, A S; Afonin, V I; Tiurin, M V; Shenderov, B A; Sazykina, Iu O; Navashin, S M

    1990-02-01

    Sensitivity of different species of Lactobacillus i.e. L. casei, L. plantarum, L. acidophillus, L. buchneri, L. jugurti and others to penicillins and cephalosporins of various generations was studied. Penicillin binding proteins (PBPs) of the Lactobacillus species were specified. It was shown that the number of PBPs depended on the Lactobacillus species. L. casei had the least number of PBPs (4) and L. brevis had the highest number of PBPs (11). Competition of 14C-benzylpenicillin with ampicillin, cefotaxime, ceftizoxime and cefoperazone for binding to separate PBPs in three strains of different Lactobacillus species was investigated. PMID:2110806

  13. Natural gas industry competitiveness study

    International Nuclear Information System (INIS)

    A national study on the competitiveness of the natural gas industry was undertaken by the BC Oil and Gas Commission in cooperation with, and with the encouragement of the Canadian Association of Petroleum Producers (CAPP). The objective of the study was to compare the cost competitiveness of natural gas exploration , production, gathering and processing in British Columbia to the costs of the same processes in Alberta. The study was carried out by building an 'expected case' for each gas producing area in British Columbia and Alberta by averaging past events in such specific areas as pool sizes, production profiles, loads, drilling success rates, gas compositions, land, drilling, exploration and production/gathering costs, third party production/gathering and processing fees and abandonment costs; by constructing a cash flow model for each case, calculating unit cost, and ranking cases. The report provides the details of the methodology, displays the results of the investigation in graphical form, comments on the results factoring in also labour costs and cost differences due to resource characteristics, identifies some trends such as an increase in the proportion of connections to smaller plants, and provides suggestions for improvements

  14. game theory, competition and cooperation

    Directory of Open Access Journals (Sweden)

    Alexandre Oliva

    2006-01-01

    Full Text Available Russel Crowe, playing John Forbes Nash Junior (aka John Nash in Ron Howards’ motion picture A beautiful mind, claims that Adam Smith’s theory that “in competition, individual ambition serves the common good” is incomplete, and that “the best result will come from everybody in the group doing what’s best for himself and the group”. Adam Smith’s motto synthesizes pretty well what happens in the competition-driven proprietary software development market, whereas Nash’s adds the cooperation that is so common even among competitors in free software markets. Every commercial free software developer tries to obtain its edge by developing better software, thus contributing to the software pool that even its competitors will be able to build upon. I.e., every free software developer does what’s best for himself, and the group, so the best outcome is achieved. The paper shows how the GNU General Public License (or GNU GPL or simply GPL licensing model can be economically favorable to developers over proprietary and even Berkeley Software Distribution (BSD-like licenses.

  15. Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico / in vitro work flow

    DEFF Research Database (Denmark)

    Kouskoumvekaki, Irene; Petersen, Rasmus K.; Fratev, Filip Filipov;

    2013-01-01

    partial agonist binding properties. Toward this end we applied an integrated in silico/in vitro workflow, based on pharmacophore-and structure-based virtual screening of the ZINC library, coupled with competitive binding and transactivation assays, and adipocyte differentiation and gene expression studies...

  16. Independent competition authorities in the EU

    Directory of Open Access Journals (Sweden)

    Johan W. van de Gronden

    2006-06-01

    Full Text Available In most Member States competition law powers have been granted to a more or less independent competition authority. The idea is that the application and enforcement of competition law should not be influenced by political and volatile considerations. However, some recent cases, most notably in the field of merger control, show that political considerations can creep into the decision-making process in competition law. In this paper we examine how the independence of the competition authorities in the United Kingdom, Germany, the Netherlands and the European Union vis-à-vis the political system has actually been regulated. We have not only looked at the independent position from the political sphere, but also at the internal design of the competition authority, i.e. how it is managed. It appears that none of the national legislators has opted for total independence. But the national competition authorities have been confronted with less political control than in the past. For the Commission, this is different, as the Commissioner for Competition does not act independently from other Commissioners, which causes an imbalance between the status of national competition authorities and the Commission. Therefore, it could be considered whether an advisory agency might be set up, having that task to issue recommendations in the field of European competition law.

  17. INNOVATIVE ASPECTS OF THE PROVIDING COMPETITIVENESS OFENTERPRISES

    Directory of Open Access Journals (Sweden)

    Н. Yamnenko

    2016-01-01

    Full Text Available The world experience of economic development shows that innovations are the catalyst of modernization and restructuring of the economy, which contributedthe strengthening of the competitiveness, profitability and innovative development of enterprisesand help to conquer new and retain existing markets. The decision of problems of activation of innovative activity of enterprises becomes the main guarantee of providing of success of market reforms. The purpose of this article is to determine of features of intercommunication between innovative activity and competitive advantages of an enterprise. The study identified the competitive advantages related to innovative activity. It is proved that the maintenance of sustainable competition position at the market depends on determination and maintenance of key success factors. It is determined the basic stages of providing of competitiveness of an enterprise through the use of its innovative capabilities. It is shown that only through developing existing and creating new competitive advantages an enterprise will be able to attain the desired state of competitiveness in the modern realities. It has suggested forming an effective competitive strategy through extensive use of innovative decisions on the basis of knowledge for providing of competitiveness of enterprises. The basis to competitive advantages should be considered the process of stimulation innovations.

  18. Interactions of natural organic substances with radionuclides: competition of other complexes - experimental results

    International Nuclear Information System (INIS)

    Humic substances as natural organic ligands occurring in most aquifer systems could have a strong influence on the behaviour of actinides in the geosphere. Their speciation may be largely dominated by humate complexes under conditions representative of natural systems. In this paper, we focus our interest on competitive effects either with major cations occurring in natural waters (such as calcium, magnesium) or with inorganic binding sites (such as hydroxide sites from particles or mineral surfaces). The case of trivalent actinides is presented and the influence of these competition processes is discussed. (authors). 22 refs., 7 figs., 1 tab

  19. SUMO-1 possesses DNA binding activity

    Directory of Open Access Journals (Sweden)

    Wieruszeski Jean-Michel

    2010-05-01

    Full Text Available Abstract Background Conjugation of small ubiquitin-related modifiers (SUMOs is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs. Protein sumoylation has been identified as an important regulatory mechanism especially in the regulation of transcription and the maintenance of genome stability. The precise molecular mechanisms by which SUMO conjugation and association act are, however, not understood. Findings Using NMR spectroscopy and protein-DNA cross-linking experiments, we demonstrate here that SUMO-1 can specifically interact with dsDNA in a sequence-independent fashion. We also show that SUMO-1 binding to DNA can compete with other protein-DNA interactions at the example of the regulatory domain of Thymine-DNA Glycosylase and, based on these competition studies, estimate the DNA binding constant of SUMO1 in the range 1 mM. Conclusion This finding provides an important insight into how SUMO-1 might exert its activity. SUMO-1 might play a general role in destabilizing DNA bound protein complexes thereby operating in a bottle-opener way of fashion, explaining its pivotal role in regulating the activity of many central transcription and DNA repair complexes.

  20. Some more results on fuzzy k-competition graphs

    Directory of Open Access Journals (Sweden)

    Sovan Samanta

    2014-01-01

    Full Text Available Fuzzy competition graph as the generalization of competition graph is introduced here. Fuzzy k-competition graph as a special type of fuzzy competition graph is defined here along with fuzzy isolated vertices. The fuzzy competition number is also introduced and investigated several properties. Isomorphism properties on fuzzy competition graphs are discussed.