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Sample records for bien phong xa

  1. Content Base Image Retrieval Using Phong Shading

    OpenAIRE

    Uday Pratap Singh; Sanjeev Jain; Gulfishan Firdose Ahmed

    2010-01-01

    The digital image data is rapidly expanding in quantity and heterogeneity. The traditional information retrieval techniques does not meet the user’s demand, so there is need to develop an efficient system for content based image retrieval. Content based image retrieval means retrieval of images from database on the basis of visual features of image like as color, texture etc. In our proposed method feature are extracted after applying Phong shading on input image. Phong shading, flattering ou...

  2. Uptake of prenatal HIV testing in Hai Phong Province, Vietnam

    DEFF Research Database (Denmark)

    Nguyen, Lan; Christoffersen, Sarah Vigh; Rasch, Vibeke

    2010-01-01

    The objective of the study is to describe the uptake of prenatal HIV testing among Vietnamese women. Exit interviews were conducted among 300 women who had delivered at Hai Phong obstetrical hospital. Information about socioeconomic characteristics and HIV testing was obtained through structured ...... tested for HIV during prenatal care and that a relationship exists between distance to the hospital and lack of HIV testing during pregnancy.......The objective of the study is to describe the uptake of prenatal HIV testing among Vietnamese women. Exit interviews were conducted among 300 women who had delivered at Hai Phong obstetrical hospital. Information about socioeconomic characteristics and HIV testing was obtained through structured...... questionnaire interviews. It was found that 45% of the women were tested for HIV before the end of 34 weeks of gestation, 5% in 35 to 40 weeks of gestation, and 55% at labor. Low educational levels, being a farmer or worker, having a low income, and living close to the hospital were associated with being tested...

  3. Clinical Scenarios for Discordant Anti-Xa

    OpenAIRE

    Jesus Vera-Aguilera; Hindi Yousef; Diego Beltran-Melgarejo; Teng Hugh Teng; Ramos Jan; Mary Mok; Carlos Vera-Aguilera; Eduardo Moreno-Aguilera

    2016-01-01

    Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Evidence Review. Guidelines and current literature search: we used PubMed, Medline, Embase, and MEDION, from 2000 to October 2013. Results. Anti-Xa test is widely used; however the assay underestimates heparin co...

  4. Cómo nadar bien

    OpenAIRE

    Navarro Valdivielso, Fernando; Díaz Ureña, Germán; González Vegas, Manuel J.

    2012-01-01

    Nadar bien o mejor es la pretensión final de este libro. Al proceso que se propone para este objetivo lo hemos denominado método NB (Nadar bien). Nuestro interés se centra en que todos los interesados y practicantes en la natación puedan perfeccionar su técnica y disfrutar del dominio de la técnica.

  5. Characterization of mangrove species using ALOS-2 PALSAR in Hai Phong city, Vietnam

    Science.gov (United States)

    Dat Pham, Tien; Yoshino, Kunihiko

    2016-06-01

    Hai Phong city is located in the Northern coast of Vietnam where the mangroves are distributed between zone I and zone II among the four mangrove zones in Vietnam. This city is vulnerable to rising sea levels associated with climate change and tropical cyclones, which are forecasted to become more severe due to the impact of climate change. In the past, mangrove forests in this city have decreased markedly because of over expansion of shrimp farming. Thus, identification of mangrove forests is important to monitor and support mangrove conservation and management in the coastal zone. The objectives of this research were to identify the locations of mangrove and characterize mangrove species in Hai Phong using HH and HV backscatters of the Advanced Land Observing Satellite 2 (ALOS-2) with enhanced Phased Array L-band Synthetic Aperture Radar (PALSAR). Image segmentation was used to identify the locations of mangrove forests. Moreover, Geographic Information System (GIS) was applied to update current status of mangrove species in 2015. The results showed that the means of HH and HV backscatter coefficients of K. obovata are lower than S. caseolaris. K. obovata has HH value around -13.9 dB until -10.3 dB and HV value around -20.6 dB until -16.2 dB. Higher HH values between about -14.9 dB and -6.8 dB and HV values between roughly -20.6 dB and -14.3 dB have observed by S. caseolaris. The total area of mangrove forest in Hai Phong in the year 2015 was around 4084 hectares, of which S. caseolaris occupied over 68% and mixed mangrove species was approximately 25.6%. This research indicates the potential for the use of L-band ALOS-2 PALSAR in characterizing mangrove forest species in the coastal zone.

  6. An assessment of the frequency of maximum rainfall events in Hai Phong and Nha Trang

    OpenAIRE

    Tran Dinh, Lan; Pham Hai, An; Vu Duy, Vinh

    2011-01-01

    Extreme heavy rain events often cause severe threat to people and their properties in high-populated, especially in coastal cities. These events can be analysed with using data observed during the least 30 years to asses how the climate change has impacted local environments in Hai Phong and Nha Trang. The extreme rainfall events is defined as high values exceeding the 95th percentile for each station. The results shows that the high rainfall (95th percentile) is 333.58mm a day in Hai Phon...

  7. Clinical Scenarios for Discordant Anti-Xa

    Directory of Open Access Journals (Sweden)

    Jesus Vera-Aguilera

    2016-01-01

    Full Text Available Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Evidence Review. Guidelines and current literature search: we used PubMed, Medline, Embase, and MEDION, from 2000 to October 2013. Results. Anti-Xa test is widely used; however the assay underestimates heparin concentration in the presence of significant AT deficiency, pregnancy, end stage renal disease, and postthrombolysis and in patients with hyperbilirubinemia; limited published data evaluating the safety and effectiveness of anti-Xa assays for managing UH therapy is available. Conclusions and Relevance. To our knowledge this is the first paper that summarizes the most common causes in which this assay can be affected, several “day to day” clinical scenarios can modify the outcomes, and we concur that these rarely recognized scenarios can be affected by negative outcomes in the daily practice.

  8. Clinical Scenarios for Discordant Anti-Xa

    Science.gov (United States)

    Vera-Aguilera, Jesus; Yousef, Hindi; Beltran-Melgarejo, Diego; Teng, Teng Hugh; Jan, Ramos; Mok, Mary; Vera-Aguilera, Carlos; Moreno-Aguilera, Eduardo

    2016-01-01

    Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Evidence Review. Guidelines and current literature search: we used PubMed, Medline, Embase, and MEDION, from 2000 to October 2013. Results. Anti-Xa test is widely used; however the assay underestimates heparin concentration in the presence of significant AT deficiency, pregnancy, end stage renal disease, and postthrombolysis and in patients with hyperbilirubinemia; limited published data evaluating the safety and effectiveness of anti-Xa assays for managing UH therapy is available. Conclusions and Relevance. To our knowledge this is the first paper that summarizes the most common causes in which this assay can be affected, several “day to day” clinical scenarios can modify the outcomes, and we concur that these rarely recognized scenarios can be affected by negative outcomes in the daily practice. PMID:27293440

  9. Les controverses du bien mourir

    OpenAIRE

    Clapasson, Dominique; Pott, Murielle

    2009-01-01

    Actuellement, la question des situations de fin de vie se pose en problème social. La dénonciation du tabou de la mort et de l’acharnement thérapeutique suscite des interrogations éthiques relatives à la souffrance des malades. Dès lors, le bien mourir devient une préoccupation qui touche chacun d’entre-nous. En Suisse, l’aspiration à une mort pacifiée se meut en deux modèles distincts de la gestion des situations de fin de vie : les soins palliatifs et l’assistance au suicide. En oppositi...

  10. Phenyltriazolinones as potent factor Xa inhibitors.

    Science.gov (United States)

    Quan, Mimi L; Pinto, Donald J P; Rossi, Karen A; Sheriff, Steven; Alexander, Richard S; Amparo, Eugene; Kish, Kevin; Knabb, Robert M; Luettgen, Joseph M; Morin, Paul; Smallwood, Angela; Woerner, Francis J; Wexler, Ruth R

    2010-02-15

    We have discovered that phenyltriazolinone is a novel and potent P1 moiety for coagulation factor Xa. X-ray structures of the inhibitors with a phenyltriazolinone in the P1 position revealed that the side chain of Asp189 has reoriented resulting in a novel S1 binding pocket which is larger in size to accommodate the phenyltriazolinone P1 substrate. PMID:20100660

  11. Nont-timber forest products collection and use by rural households living near Phong Dien Nature Reserve, central Vietnam

    OpenAIRE

    Vaňousková, Lucie

    2014-01-01

    Non-timber forest products represent important source of subsistence for households living in rural areas, particularly near the forests. These products have many possibilities of use, such as food, construction material, medicine, or, as a source of additional income. Bachelor thesis documents results of research focused on collection and utilization of non-timber forest products in four villages in Phong My commune, Thua Thien Hue province, central Vietnam. The aim of the thesis was to (i) ...

  12. Living with typhoon and flood disasters : a case study in Huong Phong commune, Tam Giang lagoon area, central Vietnam

    OpenAIRE

    Tran Thanh Duc; Tanaka, Ueru; Kobayashi, Hirohide

    2012-01-01

    Central Vietnam frequently suffers from typhoons and floods. Disaster preparedness for local residents is one of the major focuses of efforts to mitigate natural disasters. In Huong Phong commune, located beside the Tam Giang lagoon in Huong Tra district, Thua Thien Hue province, a research team focused on three specific objectives: 1) evaluating the impacts of typhoons and flooding on local residents over the past 25 years, 2) describing the activities of local authorities in responding to n...

  13. Strata of standardization: the Phong Nha dialect of Vietnamese (Quảng Bình Province) in historical perspective

    OpenAIRE

    Michaud, Alexis; Ferlus, Michel; Nguyễn, Minh-Châu

    2015-01-01

    The present research, based on first-hand data, is intended as a contribution to the study of the present-day diversity of lesser-described Vietnamese dialects, and of the range of evolutionary paths to which they testify. The Vietnamese dialect of the hamlet of Phong Nha (commune of Sơn Trạch, county of Bố Trạch, Quảng Bình) is one of the "heterodox" dialects of Vietnamese, which are known to present considerable interest for the historical study of Vietnamese and of the Vietic group at larg...

  14. Productos derivados sobre bienes de consumo

    OpenAIRE

    Francisco Venegas Martinez; Salvador Cruz Ake

    2010-01-01

    Este trabajo de investigacion desarrolla un modelo de equilibrio general con expectativas racionales en tiempo continuo util para la determinacion de precios de contratos forward, contratos futuros, bonos cupon cero y opciones europeas (de compra y venta) sobre bienes de consumo. Para ello, el modelo considera un individuo representativo en una economia con dos bienes, los cuales son producidos con tecnologias estocasticas. Por ultimo, el modelo propuesto permite examinar estrategias para obt...

  15. Assessment of surface water pollutant models of estuaries and coastal zone of Quang Ninh - Hai Phong using Spot-5 images

    Science.gov (United States)

    Ke, Luong Chinh; Van Trang, Ho Thi; Liem, Vu Huu; Tuong, Tran Ngoc; Duyen, Pham Thi

    2015-06-01

    The coastal zone and estuaries of Quang Ninh and Hai Phong have great potential not only for economic development but also for protection and conservation of biodiversity and ecosystem. Nowadays, due to industrial, agricultural and anthropogenic activities signs of water pollution in the region have been found. The level of surface water pollution can be determined by traditional methods through observatory stations. However, a traditional approach to determine water contamination is discontinuous, and thereby makes pollution assessment of the entire estuary very difficult. Nowadays, remote sensing technology has been developed and widely applied in many fields, for instance, in monitoring water environments. Remote sensing data combined with information from in-situ observations allow for extraction of polluted components in water and accurate measurements of pollution level in the large regions ensuring objectivity. According to results obtained from Spot-5 imagery of Quang Ninh and Hai Phong, the extracted pollution components, like BOD, COD and TSS can be determined with the root mean square error, the absolute mean error and the absolute mean percentage error (%): ±4.37 (mg/l) 3.86 (mg/l), 27%; ±55.32 (mg/l), 48.30 (mg/l), 14%; and ±32.90 (mg/l), 23.38 (mg/l), 28%; respectively. Obtained outcomes guarantee objectivity in assessing water contaminant levels in the investigated regions and show the advantages of remote sensing applications in Resource and Environmental Monitoring in relation to Water - Air - Land.

  16. The new factor Xa inhibitor: Apixaban

    Directory of Open Access Journals (Sweden)

    Sangeeta Bhanwra

    2014-01-01

    Full Text Available Cardiovascular diseases are still the most important cause of morbidity and mortality worldwide and anti-thrombotic treatment is widely used as a result. The currently used drugs include heparin and its derivatives, vitamin K antagonists, though efficacious, have their own set of limitations like unpredictable pharmacokinetic profile, parenteral route (with heparin and its derivatives only, narrow therapeutic window, and constant laboratory monitoring for their efficacy and safety. This lead to the development of novel factor Xa inhibitors which could be given orally, have predictable dose response relationship and are associated with lesser hemorrhagic complications. They include rivaroxaban, apixaban, and edoxaban among others. Apixaban has currently been approved for use in patients undergoing total knee or hip replacement surgery and to prevent stroke in patients with atrial fibrillation. Many trials are ongoing for apixaban to firmly establish its place in future, among the anti-thrombotic drugs.

  17. Productos derivados sobre bienes de consumo

    OpenAIRE

    Francisco Venegas Martínez; Salvador Cruz Ake

    2010-01-01

    Este trabajo de investigación desarrolla un modelo de equilibrio general con expectativas racionales en tiempo continuo útil para la determinación de precios de contratos forward , contratos futuros, bonos cupón cero y opciones europeas (de compra y venta) sobre bienes de consumo. Para ello, el modelo considera un individuo representativo en una economía con dos bienes, los cuales son producidos con tecnologías estocásticas. Por último, el modelo propuesto permite examinar estrategias para o...

  18. Research and Application of Ray Tracing Mould Based on Phong and Fresnel%基于 Phong 和 Fresnel的 Ray Tracing 模型的研究与应用

    Institute of Scientific and Technical Information of China (English)

    李尚林; 杨柳青

    2012-01-01

      This article probes into rendering object surface by Phong mould ,using Fresnel to realize refraction processing ray tracing mould and trying to optimize the rendering effect by FSAA .At last ,the test data and per-formance analysis are presented .%  初步探讨使用Phong模型渲染物体表面,并用Fresnel算法的思想实现折射处理的光线跟跟踪模型,并尝试使用全屏抗锯齿对渲染效果进行优化,最后给出该模型的测试数据与性能分析。

  19. Pharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors

    OpenAIRE

    Persson PB

    2015-01-01

    Pontus B Persson Institute of Vegetative Physiology, Berlin, GermanyApixaban and rivaroxaban are oral factor Xa inhibitors. In a recent issue of Clinical Pharmacology: Advances and Applications, Frost et al compare apixaban (2.5 mg, twice daily) to rivaroxaban (10 mg, once daily) with regard to their pharmacokinetics and pharmacodynamics.1 Both oral factor Xa inhibitors have similar half-lives. Moreover, as may seem intuitive, the twice daily regime of apixaban revealed a less pronounced peak...

  20. Transcriptional Characteristics of Xa21-mediated Defense Responses in Rice

    Institute of Scientific and Technical Information of China (English)

    Qiang Gan; Hui Bai; Xianfeng Zhao; Yong Tao; Haipan Zeng; Yuning Han; Wenyuan Song; Lihuang Zhu; Guozhen Liu

    2011-01-01

    Bacterial blight, caused by Xanthomonas oryzae pv. oryzae (Xoo), is the most destructive bacterial disease of rice. The cloned rice gene Xa21 confers resistance to a broad spectrum of Xoo races. To identify genes involved in Xa21-mediated immunity, a whole-genome oligonucleotide microarray of rice was used to profile the expression of rice genes between incompatible interactions and mock treatments at 0, 4, 8, 24, 72 and 120 h post inoculation (hpi) or between incompatible and compatible interactions at 4 hpi, respectively. A total of 441 differentially expressed genes, designated as XDGs (Xa21 mediated differentially expressed genes), were identified. Based on their functional annotations, the XDGs were assigned to 14 categories, including defense-related, signaling, transcriptional regulators. Most of the defense-related genes belonged to the pathogenesis-related gene family, which was induced dramatically at 72 and 120 hpi. Interestingly, most signaling and transcriptional regulator genes were downregulated at 4 and 8 hpi, suggesting that negative regulation of cellular signaling may play a role in the Xa21-mediated defense response. Comparison of expression profiles between Xa21- and other R gene-mediated defense systems revealed interesting common responses. Representative XDGs with supporting evidences were also discussed.

  1. Bien y principio en Platón. Bien et principe chez Platon

    OpenAIRE

    Ramón Cámara, Begoña

    2015-01-01

    La tesis doctoral Bien y principio en Platón (Universitat de València y Université Paris Ouest Nanterre La Défense), escrita por Begoña Ramón y dirigida por los Profesores Tomás Calvo y Francis Wolff, viene a cubrir una laguna en los estudios sobre la Idea del Bien en Platón. Y es que, aunque se ha escrito mucho sobre el Bien en Platón, esta cuestión de permanente interés no ha sido nunca estudiada de manera acertada y suficiente. El presente trabajo trata de aportar por primera vez una defin...

  2. Marker-aided Incorporation of Xa38, a Novel Bacterial Blight Resistance Gene, in PB1121 and Comparison of its Resistance Spectrum with xa13 + Xa21.

    Science.gov (United States)

    Ellur, Ranjith K; Khanna, Apurva; S, Gopala Krishnan; Bhowmick, Prolay K; Vinod, K K; Nagarajan, M; Mondal, Kalyan K; Singh, Nagendra K; Singh, Kuldeep; Prabhu, Kumble Vinod; Singh, Ashok K

    2016-01-01

    Basmati rice is preferred internationally because of its appealing taste, mouth feel and aroma. Pusa Basmati 1121 (PB1121) is a widely grown variety known for its excellent grain and cooking quality in the international and domestic market. It contributes approximately USD 3 billion to India's forex earning annually by being the most traded variety. However, PB1121 is highly susceptible to bacterial blight (BB) disease. A novel BB resistance gene Xa38 was incorporated in PB1121 from donor parent PR114-Xa38 using a modified marker-assisted backcross breeding (MABB) scheme. Phenotypic selection prior to background selection was instrumental in identifying the novel recombinants with maximum recovery of recurrent parent phenome. The strategy was effective in delimiting the linkage drag to <0.5 mb upstream and <1.9 mb downstream of Xa38 with recurrent parent genome recovery upto 96.9% in the developed NILs. The NILs of PB1121 carrying Xa38 were compared with PB1121 NILs carrying xa13 + Xa21 (developed earlier in our lab) for their resistance to BB. Both NILs showed resistance against the Xoo races 1, 2, 3 and 6. Additionally, Xa38 also resisted Xoo race 5 to which xa13 + Xa21 was susceptible. The PB1121 NILs carrying Xa38 gene will provide effective control of BB in the Basmati growing region. PMID:27403778

  3. Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors.

    Science.gov (United States)

    Beyer, Jacob; Trujillo, Toby; Fisher, Sheila; Ko, Ann; Lind, Stuart E; Kiser, Tyree H

    2016-07-01

    The introduction of oral direct anti-Xa anticoagulants apixaban and rivaroxaban has significantly impacted the treatment and prevention of thromboembolic disease. Clinical scenarios exist in which a quantitative assessment for degree of anticoagulation due to these agents would aid management. The purpose of this work was to evaluate the chromogenic antifactor Xa assay calibrated with heparin standards at our institution for assessment of intensity of anticoagulation with rivaroxaban or apixaban in addition to its current use for unfractionated heparin or low-molecular-weight heparin. We also aimed to propose expected steady state peak and trough antifactor Xa activities for these agents based upon dosing regimens approved for nonvalvular atrial fibrillation. Antifactor Xa activity correlated very strongly with apixaban and rivaroxaban concentration in both spiked samples and treated patient plasma samples (r (2) = .99, P < .001). This correlation was observed over a broad range (20-500 ng/mL) of drug concentrations, as sample dilution with pooled normal plasma significantly extended the range of quantitative assessment. Based on drug concentrations previously published in pharmacokinetic studies, the expected steady state peak and trough antifactor Xa activity ranges for apixaban are 1.80 to 2.20 IU/mL and 0.70 to 1.10 IU/mL, respectively. For rivaroxaban, these ranges are 3.80 to 6.20 IU/mL and 0.60 to 1.00 IU/mL, respectively. In conclusion, our findings demonstrate that heparin-calibrated antifactor Xa activity correlates strongly with apixaban and rivaroxaban concentration. The dilution of samples allowed for this correlation to be extended over the majority of on-therapy drug concentrations. PMID:26842561

  4. Prospective du commerce physique de biens culturels

    OpenAIRE

    Moati, Philippe

    2015-01-01

    Le commerce physique de biens culturels se trouve pris sous les feux croisés de deux tendances lourdes. La révolution numérique a d’abord fait naître un nouveau circuit de distribution – le commerce électronique –, lequel a immédiatement trouvé dans le domaine culturel l’un de ses terrains de développement les plus actifs. Elle a ensuite rendu possible la dématérialisation des contenus culturels : des fichiers informatiques, délivrés de machine à machine, deviennent des concurrents directs de...

  5. Prospective du commerce physique de biens culturels

    OpenAIRE

    Moati, Philippe; Chantepie, Philippe

    2015-01-01

    Si le commerce physique des biens culturels reste le maillon économique central de l’économie de la création, quel est son avenir dans le contexte de la révolution numérique qui tend à déstructurer les filières par le double effet de la dématérialisation des contenus culturels et de la migration d’une partie de l’offre et des transactions dans l’univers numérique ? L’exercice prospectif à court terme (horizon 2015) tente, à partir de l’identification des tendances lourdes et de l’observation ...

  6. El arte de vivir bien y dignamente

    Directory of Open Access Journals (Sweden)

    Aguinaga Benítez Oscar William

    1997-11-01

    Full Text Available

    Por tradición y a diferencia de otras culturas, nos han enseñado en la casa, escuela o colegio y mucho más en el trabajo a buscar amor, prosperidad, salud, felicidad y satisfacción en el exterior y jamás se nos ha hecho ver, ni se nos ha inculcado que la mayor riqueza está en el interior de cada uno de nosotros. Bien dice el doctor Dyer "se nos ha condicionado para creer que recibimos la gracia de la vida" y no para que disfrutemos de la inmortalidad de nuestro yo espiritual, se niega la opción de estar siempre acompañado de una energía que para muchos es lo divino y para otros es la conciencia.

  7. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.

    Directory of Open Access Journals (Sweden)

    Subramanian Yegneswaran

    Full Text Available Blood coagulation reactions are strongly influenced by phospholipids, but little is known about the influence of sphingolipids on coagulation mechanisms. Lysosulfatide (lyso-SF (sulfogalactosyl sphingosine prolonged factor Xa (fXa 1-stage plasma clotting assays, showing it had robust anticoagulant activity. In studies using purified clotting factors, lyso-SF inhibited >90% of prothrombin (II activation for reaction mixtures containing fXa/factor Va (fVa/II, and also inhibited II activation generation by fXa/ phospholipids and by Gla-domainless-fXa/fVa/phospholipids. When lyso-SF analogs were tested, results showed that N-acetyl-sulfatide was not anticoagulant, implying that the free amine group was essential for the anticoagulant effects of lyso-SF. Lyso-SF did not inhibit fXa enzymatic hydrolysis of small peptide substrates, showing it did not directly inhibit the fXa activity. In surface plasmon resonance studies, lyso-SF bound to immobilized inactivated fXa as well as inactivated Gla-domainless-fXa. Confirming this lyso-SF:fXa interaction, fluorescence studies showed that fluorescently-labeled-fXa in solution bound to lyso-SF. Thus, lyso-SF is an anticoagulant lipid that inhibits fXa when this enzyme is bound to either phospholipids or to fVa. Mechanisms for inhibition of procoagulant activity are likely to involve lyso-SF binding to fXa domain(s that are distinct from the fXa Gla domain. This suggests that certain sphingolipids, including lyso-SF and some of its analogs, may down-regulate fXa activity without inhibiting the enzyme's active site or binding to the fXa Gla domain.

  8. Good governance and tourism development in protected areas: The case of Phong Nha-Ke Bang National Park, central Vietnam

    Directory of Open Access Journals (Sweden)

    Anna Hübner

    2014-06-01

    Full Text Available Protected areas are increasingly expected to serve as a natural income-producing resource via the exploitation of recreational and touristic activities. Whilst tourism is often considered a viable option for generating income which benefits the conservation of a protected area, there are many cases in which insufficient and opaque planning hinder sustainable development, thereby reducing local benefit sharing and, ultimately, nature conservation. This article delineated and examined factors in governance which may underlie tourism development in protected areas. Based on Graham, Amos and Plumptre’s five good governance principles, a specific analysis was made of the Phong Nha-Ke Bang National Park in central Vietnam, which highlighted challenges in the practical implementation of governing principles arising for nature conservation, sustainable tourism development and complex stakeholder environments. Despite the limited opportunity of this study to examine the wider national and international context, the discussion facilitated an overview of the factors necessary to understand governance principles and tourism development. This article could serve as a basis for future research, especially with respect to comparative analyses of different management structures existing in Vietnam and in other contested centrally steered protected area spaces. Conservation implications: This research has shown that tourism and its development, despite a more market-oriented and decentralised policymaking, is a fragmented concept impacted by bureaucratic burden, lack of institutional capacities, top-down processes and little benefit-sharing. There is urgent need for stakeholders – public and private – to reconcile the means of protected areas for the ends (conservation by clarifying responsibilities as well as structures and processes which determine decision-making.

  9. Factors Influencing Blood Cadmium and Mercury Concentrations in Residents of Agro-Industries along Nam Phong River, Thailand

    Directory of Open Access Journals (Sweden)

    Wannanapa Srathonghon

    2016-07-01

    Full Text Available This cross-sectional analytical study aimed to determine the blood levels of cadmium (B-Cd and mercury (B-Hg and identify the factors influencing heavy metal accumulation in residents of Agro-Industries along the Nam Phong River. Quantitative data were collected, and systematic random sampling was used to obtain 420 samples for questionnaire interview and serum heavy metal testing for B-Cd and B-Hg. Multiple regression analysis was used to identify factors influencing the accumulation of heavy metals in the population and report mean differences, 95% confidence intervals and p-values. The results indicated that B-Cd levels were within the recommended safety limits for human health (5 µg/dL. However, 4.29% of respondents had Hg levels higher than the recommended safety limits for human health (10 µg/dL. Factors influencing Cd levels included sex (mean difference=0.13 µg/L, 95% CI: 0.03-0.24, p-value=0.02 and smoking (mean difference=0.14 µg/L, 95% CI: 0.09-0.19, p-value<0.001. Factors influencing Hg levels included smoking (mean difference=1.06 µg/L, 95% CI: 0.52-1.61, p-value<0.001, fish consumption (mean difference=1.11 µg/L, 95% CI: 0.22-2.01, p-value=0.01 and river snail consumption (mean difference=0.56 µg/L, 95% CI: 0.03-0.19, p-value=0.03.

  10. Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor from Bauhinia ungulata seeds.

    Science.gov (United States)

    Oliva, M L V; Andrade, S A; Juliano, M A; Sallai, R C; Torquato, R J; Sampaio, M U; Pott, V J; Sampaio, C A M

    2003-07-01

    The specific Kunitz Bauhinia ungulata factor Xa inhibitor (BuXI) and the Bauhinia variegata trypsin inhibitor (BvTI) blocked the activity of trypsin, chymotrypsin, plasmin, plasma kallikrein and factor XIIa, and factor Xa inhibition was achieved only by BuXI (K(i) 14 nM). BuXI and BvTI are highly homologous (70%). The major differences are the methionine residues at BuXI reactive site, which are involved in the inhibition, since the oxidized protein no longer inhibits factor Xa but maintains the trypsin inhibition. Quenched fluorescent substrates based on the reactive site sequence of the inhibitors were synthesized and the kinetic parameters of the hydrolysis were determined using factor Xa and trypsin. The catalytic efficiency k(cat)/K(m) 4.3 x 10(7) M(-1)sec(>-1) for Abz-VMIAALPRTMFIQ-EDDnp (lead peptide) hydrolysis by factor Xa was 10(4)-fold higher than that of Boc-Ile-Glu-Gly-Arg-AMC, widely used as factor Xa substrate. Lengthening of the substrate changed its susceptibility to factor Xa hydrolysis. Both methionine residues in the substrate influence the binding to factor Xa. Serine replacement of threonine (P(1)') decreases the catalytic efficiency by four orders of magnitude. Factor Xa did not hydrolyze the substrate containing the reactive site sequence of BvTI, that inhibits trypsin inhibitor but not factor Xa. Abz-VMIAALPRTMFIQ-EDDnp prolonged both the prothrombin time and the activated partial thromboplastin time, and the other modified substrates used in this experiment altered blood-clotting assays. PMID:12678803

  11. Effects of Water Soluble Phosphotidylserine on Bovine Factor Xa: Functional and Structural Changes Plus Dimerization

    OpenAIRE

    Majumder, Rinku; Wang, Jianfang; Lentz, Barry R.

    2003-01-01

    Previous work has shown that two molecules of a soluble form of phosphatidylserine, C6PS, bind to human and bovine factor Xa. Activity measurements along with the fluorescence of active-site-labeled human factor Xa showed that two linked sites specifically regulate the active site conformation and proteolytic activity of the human enzyme. These results imply, but cannot demonstrate, a C6PS-induced factor Xa conformational change. The purpose of this paper is to extend these observations to bo...

  12. Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux.

    Science.gov (United States)

    Ikejiri, Makoto; Wada, Hideo; Yamaguchi, Toshio; Miyazaki, Shinichi; Hasegawa, Masahiro; Wakabayashi, Hiroki; Asanuma, Kunihiro; Sakaguchi, Akane; Matsumoto, Takeshi; Ohishi, Kohshi; Fujimoto, Naoki; Yamada, Norikazu; Ito, Masaaki; Katayama, Naoyuki; Sudo, Akihiro

    2016-05-01

    Anti-Xa assays are useful for monitoring the effects of selective anti-Xa drugs, such as fondaparinux, in the prophylaxis of deep vein thrombosis. In the present study, anti-Xa activity was measured using three different assays, Testzym(®) Heparin S, STA(®)-Liquid Anti-Xa and HemosIL(®) Liquid Heparin. Anti-Xa activity in each assay gradually increased from day one after administration to day eight, and still remained on day 15. Although there were significant differences in anti-Xa activity among the three assays, the activity showed significant correlation across assays. There were no significant differences in the anti-Xa activity between patients with and without DVT or between patients with and without massive bleeding on day one before and after administration, day four, day eight and day 15. Anti-Xa activity in each assay was weakly correlated with antithrombin (AT) activity. The AT activity in patients were significantly higher on days four, eight and 15 compared with day one before and after administration, suggesting that AT activity increases following the administration of fondaparinux. The three anti-Xa assay kits tested are useful for monitoring fondaparinux treatment in orthopedic surgery patients. PMID:26922193

  13. Biene und Honig im pharaonischen Ägypten

    OpenAIRE

    Feierabend, Birgit Sonja

    2009-01-01

    Ziel der Dissertation war es, eine Gesamtbetrachtung der altägyptischen Bienenhaltung zu geben, die Bedeutung der Biene herauszuarbeiten und den Gebrauch des Honigs im alten Ägypten vorzustellen. Darüber hinaus wurde die Herkunft und Zusammensetzung des Honigs untersucht sowie ein Vergleich mit der Bienenhaltung in den Nachbarländern gezogen. rnrnDie Biene ist mehrfach als Symbol oder Dekorationselement vorzufinden. Bereits am Ende des Alten Reiches, einem Zeitpunkt, als sich die Domestikatio...

  14. A comparative approach expands the protein-protein interaction node of the immune receptor XA21 in wheat and rice

    OpenAIRE

    Yang, Baoju; Ruan, Randy; Cantu, Dario; Wang, Xiaodong; Ji, Wanquan; Ronald, Pamela C; Dubcovsky, Jorge

    2013-01-01

    The rice (Oryza sativa) OsXA21 receptor kinase is a well-studied immune receptor that initiates a signal transduction pathway leading to resistance to Xanthomonas oryzae pv. oryzae. Two homologs of OsXA21 were identified in wheat (Triticum aestivum): TaXA21-like1 located in a syntenic region with OsXA21, and TaXA21-like2 located in a non-syntenic region. Proteins encoded by these two wheat genes interact with four wheat orthologs of known OsXA21 interactors. In this study, we screened a wheat...

  15. Evaluation of Factor Xa-Specific Chromogenic Substrate Assays and the Determination of Pharmacokinetics of Fondaparinux.

    Science.gov (United States)

    Yuri, Maiko; Tabe, Yoko; Tsuchiya, Koji; Sadatsuki, Ryo; Aoki, Jun; Horii, Takashi; Iba, Toshiaki; Ohsaka, Akimichi

    2016-07-01

    Fondaparinux (FPX), a synthesized factor Xa inhibitor, is one of the most popular anticoagulants for the prevention of postoperative venous thromboembolism (VTE). Although routine monitoring is not required, the bleeding adverse events cannot be neglected, and the measurement of anti-Xa activity is expected to be monitored. The primary purpose of this study is to evaluate the performances of 2 chromogenic assays for the detection of anti-Xa activity. Furthermore, the pharmacokinetics of FPX was examined using chromogenic assays. Anti-Xa activity was measured using 2 FPX-based chromogenic substrates (S2222 and STA-Liquid Anti-Xa). The reproducibility, detection limits, linearity, and correlations between the substrates were examined using normal plasma doped with low and high concentrations of FPX formulation. In addition, anti-Xa activity in 235 clinical samples from 164 cases treated was measured, and the pharmacokinetics of FPX was evaluated. Both of the tested substrates were capable of accurately measuring the anti-Xa activity of FPX, with a lower limit of 0.05 μg/mL and a coefficient of variation of less than 10%. The repeated administration of FPX induced a gradual but significant increase in the anti-Xa activity, which was negatively correlated with body weight and estimated glomerular filtration rate. No significant correlation between the anti-Xa activity and the occurrence of postoperative VTE or bleeding event was observed. Anti-Xa activity can be successfully determined using 2 chromogenic assays and automated biochemical analyzers. The clinical significance of anti-Xa activity monitoring should be examined in the future study. PMID:26177660

  16. Purification of a Ni sup 2+ -binding protein, pNiXa, from Xenopus ovary

    Energy Technology Data Exchange (ETDEWEB)

    Beck, B.L.; Makowski, G.S.; Nomoto, S.; Sunderman, F.W. (Univ. of Connecticut, Farmington (United States))

    1991-03-11

    Previous research on nickel-induced teratogenesis in Xenopus laevis identified several Ni{sup 2+}-binding proteins, including pNiXa in Xenopus ovaries, unfertilized eggs, and embryos. A major goal of this research project is elucidating the role of pNiXa in the uptake, embryotoxicity, and teratogenicity of Ni{sup 2+} in Xenopus. To purify and identify pNiXa, ovarian tissue from mature Xenopus females was homogenized in 3 vol of Tris buffer and centrifuged. The supernatant was centrifuged; the ultracentrifugal supernatant was batch-adsorbed onto DEAE-cellulose. The pNiSa remained unbound and was subsequently adsorbed on phosphocellulose and eluted by a step-wise NaCl gradient. The pNiXa was eluted in 0.25 M NaCl; this fraction was concentrated, and further purified by reverse phase chromatography on a 5 {mu}m C-8 column, with a linear trifluoroacetic acid/acetonitrile gradient. The pNiXa was eluted at {approximately}56% acetonitrile, yielding a single protein band with mol wt {approximately}47 kD,based on SDS-PAGE analysis. Comparison of the amino acid composition of pNiXa versus the results obtained by automated Edman degradation indicated that the N-terminus of pNiXa was blocked. Sequencing of peptide fragments of pNiXa is underway.

  17. De la naturaleza del bien: contra los maniqueos

    OpenAIRE

    Agustin, Aurelio,, Santo, Obispo de Hipona

    2012-01-01

    El sumo bien, al cual no hay nada superior, es Dios; y por esto es un bien inmutable, realmente eterno e inmortal. Todos los otros bienes no son sino por él ; pero no de él. En efecto, lo que es de él, es lo que él mismo es; pero las cosas hechas por él, no son lo que es él mismo. Y por esto, si solo el es inmutable, todas las cosas que hizo, ya que las hizo de la nada, son mudables. En efecto, tan omnipotente es, que puede aún de la nada, es decir, de lo que absolutamente no es, hacer cosas ...

  18. Propriété, biens publics mondiaux, bien(s commun(s : Une lecture des concepts économiques

    Directory of Open Access Journals (Sweden)

    Jérôme Ballet

    2008-03-01

    Full Text Available La notion de bien public mondial s’est développée ces dernières années. Elle renvoie à un dépassement ambigu de la notion usuelle dans la théorie économique de bien public. A cette occasion elle ouvre le débat sur l’équité en complément de l’efficience. De ce fait, la confrontation de cette nouvelle notion avec l’analyse de l’efficience des régimes de propriété s’impose. Par ailleurs, la confrontation avec la notion de bien commun, notion elle aussi en développement, éclaire l’enjeu autour de l’équité.Property, Global Public Goods, Common Good(s : A Lecture. The concept of global public good emerged these last years. It proposes, in an ambiguous way, to go beyond the usual concept of public good. Then, added to usual questions on efficiency, the debate on fairness becomes a stake. Confrontation with analysis on property rights command attention, Furthermore, confrontation with the concept of common good, also a developing concept, highlight stake around fairness.

  19. RIVAROXABAN: AN ORAL DIRECT INHIBITOR OF FACTOR X-A

    Directory of Open Access Journals (Sweden)

    Mehta Hiren R

    2011-08-01

    Full Text Available Venous thrombo embolism (VTE, which includes deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality in patients undergoing major orthopaedic surgery, and routine thrombo prophylaxis has been the standard of care over the last 20 years. Currently available options for the prevention of venous thrombo embolism in major orthopedic surgery include low-molecular-weight heparins, vitamin K antagonists and, more recently, the synthetic pentasaccharide fondaparinux. Although effective, these drugs have several limitations, and new oral antithrombotics offering predictable, effective and safe anticoagulation are strongly needed. This overview focuses on the most advanced oral direct inhibitors of factor Xa, rivaroxaban.Rivaroxaban, an oral oxazolidinone-based anticoagulant, is a potent, selective direct inhibitor of factor Xa that is used in the prevention of venous thrombo embolism in adult patients after total hip replacement (THR or total knee replacement (TKR surgery. In four large, clinical trials, oral rivaroxaban was more effective than subcutaneous enoxaparin in preventing postoperative VTE in patients undergoing total hip replacement or total knee replacement surgery. Notably, the superior efficacy of rivaroxaban was achieved with a low but not significant increase in the incidence of major bleeding episodes. In addition, preliminary pharma co-economic analyses in several countries indicate that rivaroxaban is a cost-effective treatment strategy versus enoxaparin. Although the position of rivaroxaban relative to other therapies remains to be fully determined, it is an effective emerging option for the prevention of venous thrombo embolism following total hip replacement and total knee replacement.

  20. Bien común y ética pública: Alcances y límites del concepto tradicional de bien común

    OpenAIRE

    Dorando J. Michelini

    2007-01-01

    Con el concepto de bien común se ha hecho referencia, a través de la historia, a aquellos bienes materiales e inmateriales que no se circunscriben a una persona sino que remiten a todos y cada uno de los miembros de la sociedad. Entre esos bienes suelen contarse elementos básicos para la supervivencia humana biológica, como el aire y el agua, pero también el derecho a participar en el usufructo de los bienes de la cultura. En algunos casos, el bien común es equiparado al bienestar general; en...

  1. Fast rotation of a subkilometer-sized near-Earth object 2011 XA{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Urakawa, Seitaro [Bisei Spaceguard Center, Japan Spaceguard Association, 1716-3 Okura, Bisei, Ibara, Okayama 714-1411 (Japan); Ohtsuka, Katsuhito [Tokyo Meteor Network, 1-27-5 Daisawa, Setagaya-ku, Tokyo 155-0032 (Japan); Abe, Shinsuke [Department of Aerospace Engineering, College of Science and Technology, Nihon University, 7-24-1 Narashinodai, Funabashi, Chiba 274-8501 (Japan); Ito, Takashi [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Nakamura, Tomoki, E-mail: urakawa@spaceguard.or.jp [Department of Earth and Planetary Material Sciences, Graduate School of Science, Tohoku University, Aoba, Sendai, Miyagi 980-8578 (Japan)

    2014-05-01

    We present light curve observations and their multiband photometry for near-Earth object (NEO) 2011 XA{sub 3}. The light curve has shown a periodicity of 0.0304 ± 0.0003 days (= 43.8 ± 0.4 minutes). The fast rotation shows that 2011 XA{sub 3} is in a state of tension (i.e., a monolithic asteroid) and cannot be held together by self-gravitation. Moreover, the multiband photometric analysis indicates that the taxonomic class of 2011 XA{sub 3} is S-complex, or V-type. Its estimated effective diameter is 225 ± 97 m (S-complex) and 166 ± 63 m (V-type), respectively. Therefore, 2011 XA{sub 3} is a candidate for the second-largest, fast-rotating, monolithic asteroid. Moreover, the orbital parameters of 2011 XA{sub 3} are apparently similar to those of NEO (3200) Phaethon, but F/B-type. We computed the orbital evolutions of 2011 XA{sub 3} and Phaethon. However, the results of the computation and distinct taxonomy indicate that neither of the asteroids is of common origin.

  2. Fast rotation of a subkilometer-sized near-Earth object 2011 XA3

    International Nuclear Information System (INIS)

    We present light curve observations and their multiband photometry for near-Earth object (NEO) 2011 XA3. The light curve has shown a periodicity of 0.0304 ± 0.0003 days (= 43.8 ± 0.4 minutes). The fast rotation shows that 2011 XA3 is in a state of tension (i.e., a monolithic asteroid) and cannot be held together by self-gravitation. Moreover, the multiband photometric analysis indicates that the taxonomic class of 2011 XA3 is S-complex, or V-type. Its estimated effective diameter is 225 ± 97 m (S-complex) and 166 ± 63 m (V-type), respectively. Therefore, 2011 XA3 is a candidate for the second-largest, fast-rotating, monolithic asteroid. Moreover, the orbital parameters of 2011 XA3 are apparently similar to those of NEO (3200) Phaethon, but F/B-type. We computed the orbital evolutions of 2011 XA3 and Phaethon. However, the results of the computation and distinct taxonomy indicate that neither of the asteroids is of common origin.

  3. Reconsiderando las tecnologías sociales como bienes comunes

    Directory of Open Access Journals (Sweden)

    Ariel Vercelli

    2010-05-01

    Full Text Available En este artículo se describen las relaciones que se plantean entre las regulaciones sobre bienes materiales e intelectuales y las “tecnologías sociales”. Para ello, se utilizan algunas herramientas teórico-metodológicas provenientes del análisis socio-técnico y se aprovechan desarrollos conceptuales referidos a la caracterización de los “bienes comunes”. El artículo es parte de un ejercicio teórico donde las tecnologías sociales se consideran como bienes comunes. Con ello se busca problematizar el carácter jurídico-político que pueden adquirir algunas tecnologías sociales y, a su vez, analizar posibles formas de privatización y apropiación que éstas podrían sufrir por parte de corporaciones comerciales y Estados. In this article, the author describes relations proposed between the regulation of material and intellectual goods and the “social technologies.” To that end, theoretical-methodological tools from social-technical analysis are used, and conceptual developments related to the characterization of “common goods” are applied. The article is part of a theoretical exercise in which social technologies are taken to be common goods. For that purpose, the legal-political character that some social technologies may acquire is problematized, and, at the same time possible forms of privatization and appropriation that these might undergo by private business or the state are analyzed.

  4. Bien común, derecho social y ciencias sociales

    OpenAIRE

    Zamagni, Stefano

    2014-01-01

    Stefano Zamagni, Catedrático de Economía Política de la Universidad de Bolonia. Bien común, Derecho Social y Ciencias Sociales. Conferencia en la Universidad de Málaga el 4 de noviembre de 2014. Facultad de Derecho. Departamento de Derecho del Trabajo y de la Seguridad Social. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Stefano Zamagni, profesor de Economía Política en la Universidad de Bolonia y en la John Hopkins University, es uno de los princi...

  5. 3D/3D registration of coronary CTA and biplane XA reconstructions for improved image guidance

    Energy Technology Data Exchange (ETDEWEB)

    Dibildox, Gerardo, E-mail: g.dibildox@erasmusmc.nl; Baka, Nora; Walsum, Theo van [Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Punt, Mark; Aben, Jean-Paul [Pie Medical Imaging, 6227 AJ Maastricht (Netherlands); Schultz, Carl [Department of Cardiology, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Niessen, Wiro [Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, 2628 CJ Delft, The Netherlands and Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands)

    2014-09-15

    Purpose: The authors aim to improve image guidance during percutaneous coronary interventions of chronic total occlusions (CTO) by providing information obtained from computed tomography angiography (CTA) to the cardiac interventionist. To this end, the authors investigate a method to register a 3D CTA model to biplane reconstructions. Methods: The authors developed a method for registering preoperative coronary CTA with intraoperative biplane x-ray angiography (XA) images via 3D models of the coronary arteries. The models are extracted from the CTA and biplane XA images, and are temporally aligned based on CTA reconstruction phase and XA ECG signals. Rigid spatial alignment is achieved with a robust probabilistic point set registration approach using Gaussian mixture models (GMMs). This approach is extended by including orientation in the Gaussian mixtures and by weighting bifurcation points. The method is evaluated on retrospectively acquired coronary CTA datasets of 23 CTO patients for which biplane XA images are available. Results: The Gaussian mixture model approach achieved a median registration accuracy of 1.7 mm. The extended GMM approach including orientation was not significantly different (P > 0.1) but did improve robustness with regards to the initialization of the 3D models. Conclusions: The authors demonstrated that the GMM approach can effectively be applied to register CTA to biplane XA images for the purpose of improving image guidance in percutaneous coronary interventions.

  6. El mercado de bienes ilegales: el caso de la droga

    Directory of Open Access Journals (Sweden)

    Becker , Gary S.

    2006-12-01

    Full Text Available Este artículo examina los costos de reducir el consumo de un bien declarando ilegal su producción y castigando a los productores ilegales. Las drogas son el ejemplo más destacado. Cuanto más inelástica es la demanda o la oferta, mayor es el incremento del costo social de reducir la producción con mayor represión. Así, el gasto público óptimo de capturar y condenar a los proveedores ilegales no sólo depende de la diferencia entre los valores social y privado del consumo sino también de las elasticidades. Cuando la demanda y la oferta no son muy elásticas, no paga hacer cumplir la prohibición a menos que el valor social sea negativo. También muestra que un impuesto monetario reduce la producción e incrementa el precio más que la represión óptima del bien si fuera ilegal, aunque algunos productores vayan a la clandestinidad para evadir el impuesto monetario. Los impuestos al consumo y las restricciones a las cantidades no son equivalentes cuando la represión tiene costos

  7. The Matrix Equation XA- AX=Xαg(X over Fields or Rings

    Directory of Open Access Journals (Sweden)

    Gerald Bourgeois

    2014-01-01

    Full Text Available Let n,α∈N≥2 and let K be an algebraically closed field with characteristic 0 or greater than n. We show that if f∈K[X] and A,B∈Mn(K satisfy [A,B]=f(A, then A,B are simultaneously triangularizable. Let R be a reduced ring such that n! is not a zero divisor and let A be a generic matrix over R; we show that X=0 is the sole solution of AX-XA=Xα. Let R be a commutative ring with unity; let A be similar to diag(λ1In1,…,λrInr such that, for every i≠j,λi-λj is not a zero divisor. If X is a nilpotent solution of XA-AX=Xαg(X where g∈R[X], then AX=XA.

  8. On Diophantine Equations of the Form $(x-a_1)(x-a_2)\\ldots(x-a_k)+r=y^n$

    Indian Academy of Sciences (India)

    Manisha Kulkarni; B Sury

    2011-08-01

    Erdős and Selfridge [3] proved that a product of consecutive integers can never be a perfect power. That is, the equation $x(x+1)(x+2)\\ldots(x+(m-1))=y^n$ has no solutions in positive integers $x,m,n$ where $m,n>1$ and $y\\in Q$. We consider the equation $$(x-a_1)(x-a_2)\\ldots(x-a_k)+r=y^n$$ where $0≤ a_1 < a_2 <\\cdots < a_k$ are integers and, with $r\\in Q,n≥ 3$ and we prove a finiteness theorem for the number of solutions in $Z,y$ in . Following that, we show that, more interestingly, for every nonzero integer >2 and for any nonzero integer which is not a perfect -th power for which the equation admits solutions, is bounded by an effective bound.

  9. "XA6" octahedra influencing the arrangement of anionic groups and optical properties in inverse-perovskite [B6O10]XA3 (X = Cl, Br; A = alkali metal).

    Science.gov (United States)

    Yang, Zhihua; Lei, Bing-Hua; Yang, Bin; Pan, Shilie

    2016-06-01

    Exploring the effect of microscopic units, which set up the perovsikte framework, is of importance for material design. In this study, a series of borate halides with inverse-perovskite structures [B6O10]XA3 (X = Cl, Br; A = alkali metal) have been studied. It was revealed that the distortion and volume of XA6 octahedra influence the arrangement of anionic groups, which leads to the flexibility of the perovskite-related framework and differences in optical properties. Under the structural control scheme, the structure of Rb3B6O10Cl was predicted. The stability of the predicted structure was confirmed by an ab initio density functional theory-based method. The calculation shows Rb3B6O10Cl has a short UV cutoff edge of less than 200 nm, a moderate birefringence and a large second harmonic generation response. PMID:27211304

  10. Le commerce électronique de biens culturels : contributions empiriques

    OpenAIRE

    Eang, Bora

    2012-01-01

    Cette thèse se présente sous la forme d’un volume de 134 pages composé de 5 articles de recherche. La thèse est une contribution empirique à la littérature qui s’est développée depuis le début des années 2000 sur les bouleversements introduits par Internet sur le commerce des biens culturels. Elle examine plus particulièrement un ensemble de questions portant sur la complémentarité ou la substitution des canaux de distribution, physiques et virtuels, l’effet de « Longue Traîne » et la dispers...

  11. Introduction of a rice blight resistance gene, Xa21, into five Chinese rice varieties through an Agrobacterium-mediated system

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A cloned gene, Xa21 was transferred into five widely-used Chinese rice varieties through an Agrobacterium-mediated system, and over 110 independent transgenic lines were obtained. PCR and Southern analysis of transgenic plants revealed the integration of the whole Xa21 gene into the host genomes. The integrated Xa21 gene was stably inherited, and segregated in a 3∶1 ratio in the selfed T1 generation when one copy of the gene was integrated in the transformants. Inoculation tests displayed that transgenic T0 plants and Xa21 PCR-positive T1 plants were highly resistant to bacterial blight disease. The selected Xa21 homozygous resistant transgenic lines with desirable qualities may be propagated as new varieties or utilized in hybrid rice breeding.

  12. Phong trào Đông Du, Nhật Bản, và các mối quiân hệ gauốc tế ở Voiễn Đông

    Czech Academy of Sciences Publication Activity Database

    Karlová, Petra

    Hanoi : University of Social Sciences and Humanities, VNU - Hanoi, 2005, s. 184-195. ISBN N. [Quan he van hoa, giao duc Viet Nam - Nhat Ban va 100 nam phong trao Dong Du. Hanoi (VN), 21.11.2005-22.11.2005] Institutional research plan: CEZ:AV0Z90210515 Keywords : Vietnam * Phan Boi Chau * Dong Du Subject RIV: AB - History

  13. Pleiotropic effects of factor Xa and thrombin : what to expect from novel anticoagulants

    NARCIS (Netherlands)

    Spronk, Henri M. H.; de Jong, Anne Margreet; Crijns, Harry J.; Schotten, Ulrich; Van Gelder, Isabelle C.; ten Cate, Hugo

    2014-01-01

    Factor Xa and thrombin are well-known components of the coagulation cascade and have been proven to be viable targets for effective anticoagulation treatment. However, accumulating evidence suggests that these serine proteases are also crucial modulators of other cellular mechanisms through the acti

  14. The role of structural information in the discovery of direct thrombin and factor Xa inhibitors.

    Science.gov (United States)

    Nar, Herbert

    2012-05-01

    The quest for novel medications to treat thromboembolic disorders such as venous thrombosis, pulmonary embolism and stroke received a boost when the 3D structures of two major players in the blood coagulation cascade were determined in 1989 and 1993. Structure-guided design of inhibitors of thrombin (factor IIa, fIIa) and factor Xa (fXa) eventually led to the discovery of potent, selective, efficacious, orally active and safe compounds that proved successful in clinical studies. In 2008, the direct thrombin inhibitor dabigatran etexilate developed by Boehringer Ingelheim became the first novel antithrombotic molecular entity to enter the market in 50 years. Additional compounds targeting factor Xa were subsequently granted marketing authorization or are in late-stage clinical studies. In this review, I use selected case studies to describe the discovery of novel fIIa and fXa inhibitors, with a particular emphasis on the pre-eminent role that structural information played in this process. PMID:22503439

  15. Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.

    Directory of Open Access Journals (Sweden)

    Kathleen E Brummel-Ziedins

    Full Text Available Factor (fXa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate hemostasis in various populations. In this study, we evaluate the potential of computationally derived time courses of fXa generation as another approach for investigating thrombotic risk. Utilizing the case (n = 473 and control (n = 426 population from the Leiden Thrombophilia Study and each individual's plasma protein factor composition for fII, fV, fVII, fVIII, fIX, fX, antithrombin and tissue factor pathway inhibitor, tissue factor-initiated total active fXa generation was assessed using a mathematical model. FXa generation was evaluated by the area under the curve (AUC, the maximum rate (MaxR and level (MaxL and the time to reach these, TMaxR and TMaxL, respectively. FXa generation was analyzed in the entire populations and in defined subgroups (by sex, age, body mass index, oral contraceptive use. The maximum rates and levels of fXa generation occur over a 10- to 12- fold range in both cases and controls. This variation is larger than that observed with thrombin (3-6 fold in the same population. The greatest risk association was obtained using either MaxR or MaxL of fXa generation; with an ∼2.2 fold increased risk for individuals exceeding the 90(th percentile. This risk was similar to that of thrombin generation(MaxR OR 2.6. Grouping defined by oral contraceptive (OC use in the control population showed the biggest differences in fXa generation; a >60% increase in the MaxR upon OC use. FXa generation can distinguish between a subset of individuals characterized by overlapping thrombin generation profiles. Analysis of fXa generation is a phenotypic characteristic which may prove to be a more sensitive discriminator than thrombin generation among all individuals.

  16. Los bienes comunes intangibles en el capitalismo cognitivo.

    Directory of Open Access Journals (Sweden)

    Álvaro Ramis Olivos

    2014-10-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Este texto analizará críticamente la actual fase económica para mostrar la importancia de los bienes comunes intangibles. Sondea la tesis de un nuevo modo de producción «en ciernes», basado en la gestión colaborativa. Analiza los intangibles de acuerdo a su calidad y carácter. Compara los sistemas de patentes y derechos de propiedad intelectual que permiten su apropiación y las resistencias a su «comoditización» desde el software libre y las propuestas de flexibilización de derechos de autor. Advierte sobre el «fetichismo tecnológico» y propone un marco mínimo de discernimiento en dilemas vinculados a estas materias. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

  17. Ciberciudadanía, cultura y bienes públicos

    Directory of Open Access Journals (Sweden)

    Álvarez, J. Francisco

    2009-06-01

    Full Text Available Net society is provoking dramatic changes in several aspects of our daily life as cultural traits, business and the more disparages spheres of privacy and social life. We must attend both to freedom of access and to new services generation because of the peculiar form public goods are raising in the Net. To supersede individual capability limitations and to diffuse digital and cultural gaps, electronic government could be a cultural decisive tool in this phase of cibersociety enhancement. Technologies enhanced the human capabilities, as well as with the social actions and its framework, including cultural production and management. Technologies are also transforming the generation, reproduction and transmission of (social knowledge.La sociedad red transforma la vida cotidiana, las diversas manifestaciones culturales, los negocios, las esferas más diversas de la vida privada y social. La forma en que se generan los bienes públicos en la red exige una preocupación explícita por la libertad de acceso y la generación de nuevos servicios, que ayuden a superar limitaciones de los individuos y faciliten desdibujar las diversas brechas digitales y ciberculturales. El gobierno electrónico resulta culturalmente decisivo en esta fase de expansión de la cibersociedad. Las tecnologías amplían las capacidades humanas, expanden el espacio y las formas de acción social, incluidas la producción y gestión cultural. También producen cambios en las formas de generación, reproducción y transmisión del conocimiento (social.

  18. Binding of human factors X and Xa to HepG2 and J82 human tumor cell lines. Evidence that factor Xa binds to tumor cells independent of factor Va

    International Nuclear Information System (INIS)

    Previous studies demonstrated that several cultured human tumor cell lines potentiate the conversion of prothrombin to thrombin by factor Xa and calcium in the absence of exogenous factor Va. In the present study, the specific binding of radioiodinated preparations of human factor X and factor Xa to a human hepatocellular carcinoma cell line (HepG2) that constitutively synthesizes a factor V/Va molecule, and a human bladder carcinoma cell line (J82) that does not synthesize factor V/Va, was examined. Radioiodinated factor Xa bound specifically to J82 and HepG2 cells, whereas no significant specific binding of 125I-factor X to either cell was observed. The binding isotherm of 125I-factor Xa to each tumor cell line exhibited a hyperbolic profile, and Scatchard analysis demonstrated a single class of binding site for factor Xa on each cell surface with Kd values of 1.66 +/- 0.39 and 1.64 +/- 0.52 nM and 566,000 +/- 71,000 and 28,000 +/- 6,000 binding sites/cell for HepG2 and J82 cells, respectively. Thrombin formation by cell-bound factor Xa was hyperbolic and saturable at 5 nM factor Xa on each cell line. Hanes-Woolf plots of the prothrombin activation data indicated that half-maximal rates of thrombin formation occurred at factor Xa concentrations of 1.50 +/- 0.43 nM and 1.42 +/- 0.48 nM on HepG2 and J82 cells, respectively. Pretreatment of J82 cells with polyclonal anti-human factor V IgG had no measurable effect on either the binding of 125I-factor Xa or prothrombin activation. However, pretreatment of HepG2 cells with anti-human factor V IgG inhibited prothrombin activation in a dose-dependent manner, but did not inhibit the binding of factor Xa to this cell. When both cell lines were preincubated with exogenous human factor Va, the binding of factor Xa to either HepG2 or J82 cells was marginally affected

  19. Economía institucional de un bien mayor

    Directory of Open Access Journals (Sweden)

    Óscar A. Alfonso Roa

    2007-12-01

    Full Text Available La provisión de los servicios de acueducto y alcantarillado en Colombia ha sido sometida, desde 1994, a una terapia consistente en la promoción de un modelo empresarial que se abre paso a costa de la estigmatización del municipio como mal prestador y como asignador ineficiente de unos recursos escasos. a quince años de operación del modelo empresarial y en desarrollo del Acto Legislativo 04 de 2007, el Gobierno nacional ha introducido otra reforma, en esta oportunidad al Sistema General de Participaciones, esgrimiendo en la exposición de motivos los mismos argumentos de antaño, cuando en verdad mediante la prestación directa de los municipios sólo se provee de estos servicios a una porción minoritaria de la población urbana del país. En la primera parte se discute la noción del agua potable como bien mayor y en la segunda se presenta una breve síntesis de la evolución institucional de la provisión del agua potable en colombia. en la tercera parte se discuten algunos rasgos centrales del proceso de urbanización de la población colombiana a la que se sirve con el servicio de acueducto mientras que en la última se analiza la coyuntura reciente con énfasis en la crítica a la reforma introducida por el acto Legislativo 04 de 2007. este artículo propone otros puntos de vista para criticar, además de la reforma en curso, las fallas de un esquema de provisión cifrado en un enfoque empresarial sometido a una inocua regulación, que no logra conciliar los intereses de ampliación de las ganancias de las empresas de servicios públicos con las aspiraciones sociales en materia de universalización y calidad de los servicios de acueducto y alcantarillado.

  20. Inhibition of thrombin and factor Xa by Fucus evanescens fucoidan and its modified analogs.

    Science.gov (United States)

    Lapikova, E S; Drozd, N N; Tolstenkov, A S; Makarov, V A; Zvyagintseva, T N; Shevchenko, N M; Bakunina, I U; Besednova, N N; Kuznetsova, T A

    2008-09-01

    Specimens of fucoidan extracted from Fucus evanescens were purified from protein and polyphenols, deacetylated and depolymerized by fucoidanase for evaluation of their biological activity. Deacetylation did not modify the capacity of fucoidan to inhibit thrombin and factor Xa, while purification from protein and polyphenols reduced this capacity. Depolymerization of fucoidan increased its capacity to inhibit thrombin mainly through heparin cofactor II. All the studied specimens formed complexes with protamine sulfate. PMID:19240852

  1. Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data?

    OpenAIRE

    Carmen Escalante; Syed Wamique Yusuf; Vahid Afshar-Kharghan; Ali Zalpour; Kroll, Michael H.

    2011-01-01

    The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment has been anticoagulation therapy, unless contraindicated. This therapy consists of unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), factor Xa inhibitor, or vitamin K antagonist (VKA). Current guidelines recommend LMWH over VKA for the treat...

  2. Comparative nutritional compositions and proteomics analysis of transgenic Xa21 rice seeds compared to conventional rice.

    Science.gov (United States)

    Gayen, Dipak; Paul, Soumitra; Sarkar, Sailendra Nath; Datta, Swapan K; Datta, Karabi

    2016-07-15

    Transgenic rice expressing the Xa21 gene have enhanced resistant to most devastating bacterial blight diseases caused by Xanthomonas oryzae pv. oryzae (Xoo). However, identification of unintended modifications, owing to the genetic modification, is an important aspect of transgenic crop safety assessment. In this study, the nutritional compositions of seeds from transgenic rice plants expressing the Xa21 gene were compared against non-transgenic rice seeds. In addition, to detect any changes in protein translation levels as a result of Xa21 gene expression, rice seed proteome analyses were also performed by two-dimensional gel electrophoresis. No significant differences were found in the nutritional compositions (proximate components, amino acids, minerals, vitamins and anti-nutrients) of the transgenic and non-transgenic rice seeds. Although gel electrophoresis identified 11 proteins that were differentially expressed between the transgenic and non-transgenic seed, only one of these (with a 20-fold up-regulation in the transgenic seed) shows nutrient reservoir activity. No new toxins or allergens were detected in the transgenic seeds. PMID:26948618

  3. Bien común y ética pública: Alcances y límites del concepto tradicional de bien común

    Directory of Open Access Journals (Sweden)

    Dorando J. Michelini

    2007-12-01

    Full Text Available Con el concepto de bien común se ha hecho referencia, a través de la historia, a aquellos bienes materiales e inmateriales que no se circunscriben a una persona sino que remiten a todos y cada uno de los miembros de la sociedad. Entre esos bienes suelen contarse elementos básicos para la supervivencia humana biológica, como el aire y el agua, pero también el derecho a participar en el usufructo de los bienes de la cultura. En algunos casos, el bien común es equiparado al bienestar general; en otros, a la suma de intereses particulares o al beneficio de la mayoría, como cuando se busca el mayor bien para el mayor número posible de individuos. Más allá de las diversas interpretaciones, la promoción del bien común sigue siendo en la actualidad un objetivo clave del Estado en el ideario democrático y un tema recurrente de la ética pública. En lo que sigue, se reconstruye críticamente el concepto tradicional de bien común, haciendo especial referencia a las obras de Platón, Aristóteles y Santo Tomas, con el fin de sentar bases para una nueva comprensión de la idea de bien común en sociedades pluralistas y democráticas.With the concept of commom good reference has been made, along history, to those material and immaterial goods which are not circumscribed to a person, but remit to each and every member of society. Among those goods, basic elements for biological human survival, such as air and water, are usually included, but also the right to participate of the profits of cultural goods. In some cases, commom good has been made equivalent to common wellfare; in others, to the summation of particular interests or to the benefit of the majority. Beyond the diverse interpretations, the promotion of common good continues at present to be a key aim of State in the democratic ideary and a recurrent issue in public ethics. In what follows, the concept of traditional common good has been reconstructed, making special reference to the

  4. The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots.

    Directory of Open Access Journals (Sweden)

    Nicholas Holton

    2015-01-01

    Full Text Available During plant immunity, surface-localized pattern recognition receptors (PRRs recognize pathogen-associated molecular patterns (PAMPs. The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance. Thus, there is a great interest in understanding the mechanisms of PRR-mediated resistance across different plant species. Two well-characterized plant PRRs are the leucine-rich repeat receptor kinases (LRR-RKs EFR and XA21 from Arabidopsis thaliana (Arabidopsis and rice, respectively. Interestingly, despite being evolutionary distant, EFR and XA21 are phylogenetically closely related and are both members of the sub-family XII of LRR-RKs that contains numerous potential PRRs. Here, we compared the ability of these related PRRs to engage immune signaling across the monocots-dicots taxonomic divide. Using chimera between Arabidopsis EFR and rice XA21, we show that the kinase domain of the rice XA21 is functional in triggering elf18-induced signaling and quantitative immunity to the bacteria Pseudomonas syringae pv. tomato (Pto DC3000 and Agrobacterium tumefaciens in Arabidopsis. Furthermore, the EFR:XA21 chimera associates dynamically in a ligand-dependent manner with known components of the EFR complex. Conversely, EFR associates with Arabidopsis orthologues of rice XA21-interacting proteins, which appear to be involved in EFR-mediated signaling and immunity in Arabidopsis. Our work indicates the overall functional conservation of immune components acting downstream of distinct LRR-RK-type PRRs between monocots and dicots.

  5. Fine mapping of the rice bacterial blight resistance gene Xa-4 and its co-segregation marker

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    An F2 population developed from the Xa-4 near isogenic lines,IR24 and IRBB4,was used for fine mapping of the rice bacterial blight resistance gene,Xa-4.Some restriction fragment length polymorphism (RFLP) markers on the high-density map constructed by Harushima et al.and the amplified DNA fragments homologous to the conserved domains of plant disease resistance (R) genes were used to construct the genetic linkage map around the gene Xa-4 by scoring susceptible individuals in the population.Xa-4 was mapped between the RFLP marker G181 and the polymerase chain reaction (PCR) marker M55.The R gene homologous fragment marker RS13 was found co-segregating with Xa-4 by analyzing all the plants in the population.This result opened an approach to map-based cloning of this gene,and marker RS13 can be applied to molecular marker-assisted selection of Xa-4 in rice breeding programs.

  6. La comunidad de bienes como forma jurídica de empresa

    OpenAIRE

    Vaticón Fernández, José Antonio

    2014-01-01

    Este trabajo trata sobre la Comunidad de Bienes, regulada en el los artículos 396 al 406 del Código Civil. Las características que definen a una Comunidad Bienes son las siguientes: 1. No tiene personalidad jurídica propia. 2. Hace falta un contrato privado para poder ejercer la actividad. 3. No se exige una aportación mínima de dinero. 4. Se exige un mínimo de dos socios. 5. La responsabilidad hacia terceros es ilimitada. En conclusión, la Comunidad de Bienes no es la...

  7. Bienes comunes, nuevos cercamientos y economía política popular

    OpenAIRE

    Lain Escandell, Bru

    2015-01-01

    Este artículo discute la creciente importancia que están adoptando los llamados bienes comunes en el ámbito de la creación cultural. Para ello se discuten críticamente dos importantes analogías que han emergido en los últimos años: la primera, entre los bienes comunes naturales y los digitales y la segunda, entre los viejos y los nuevos cercamientos digitales. El artículo demuestra que, si bien es cierto que ambas comparaciones deben abordarse con cautela, las similitudes entre ambas son nota...

  8. Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors.

    Science.gov (United States)

    Van Huis, Chad A; Bigge, Christopher F; Casimiro-Garcia, Agustin; Cody, Wayne L; Dudley, Danette A; Filipski, Kevin J; Heemstra, Ronald J; Kohrt, Jeffrey T; Narasimhan, Lakshmi S; Schaum, Robert P; Zhang, Erli; Bryant, John W; Haarer, Staci; Janiczek, Nancy; Leadley, Robert J; McClanahan, Thomas; Thomas Peterson, J; Welch, Kathleen M; Edmunds, Jeremy J

    2007-06-01

    A novel series of pyrrolidine-1,2-dicarboxamides was discovered as factor Xa inhibitors using structure-based drug design. This series consisted of a neutral 4-chlorophenylurea P1, a biphenylsulfonamide P4 and a D-proline scaffold (1, IC(50) = 18 nM). Optimization of the initial hit resulted in an orally bioavailable, subnanomolar inhibitor of factor Xa (13, IC(50) = 0.38 nM), which was shown to be efficacious in a canine electrolytic model of thrombosis with minimal bleeding. PMID:17581239

  9. TRASMISIÓN DE BIENES Y REGISTRO DE LA PROPIEDAD EN ESPAÑA (SEGUNDA PARTE

    Directory of Open Access Journals (Sweden)

    Joaquín Sánchez Cebrián

    2009-01-01

    Full Text Available La circulación de los bienes en el tráfico jurídico por la voluntad de los particulares es un tema crucial que interesa, no sólo a las partes del contrato, sino, a todos en general, y, en particular, a los acreedores del transmitente o del adquirente y a los terceros adquirentes de derechos sobre el bien. En este trabajo se analizará el régimen de trasmisión de los bienes por negocio inter vivos en el Derecho español, dentro del marco europeo, y con particular referencia a la trasmisión inmobiliaria. España adopta un peculiar sistema de trasmisión de los bienes porque se establecen reglas genéricas cuya aplicación se da con independencia de la naturaleza mueble o inmueble del bien; pero a su lado se superponen otras que tratan de fijar los efectos de la publicidad registral inmobiliaria. La coordinación entre dichas reglas produce un original resultado, que puede constituir el punto de encuentro de los diversos sistemas registrales europeos.

  10. Identification and gene prediction of a 24 kb region containing xa5, a recessive bacterial blight resistance gene in rice (Oryza sativa L.)

    Institute of Scientific and Technical Information of China (English)

    ZHONG Yiming; JIANG Guanghuai; CHEN Xuewei; XIA Zhihui; LI Xiaobing; ZHU Lihuang; ZHAI Wenxue

    2003-01-01

    Rice xa5 gene provides recessive, race-specific resistance to bacterial blight disease caused by the pathogen Xanthomonas oryzae pv. oryzae and has great value for research and breeding. In an effort to clone xa5, an F2 population of 4892 individuals was developed from the xa5 near isogenic lines, IR24 and IRBB5. A fine mapping procedure was conducted and tightly linked RFLP markers were used to screen a BAC library of IRBB56, a resistant rice line containing the xa5 gene. A 213 kb contig covering the xa5 locus was constructed. According to the sequences from the International Rice Genome Sequening Project (IRGSP), the Chinese Superhybrid Rice Genome Project (SRGP) and some sub-clones of the contig, twelve SSLP and CAPS markers were developed for fine mapping. The xa5 gene was mapped to a 0.3 cM interval between markers K5 and T4, which spanned an interval of approximately 24 kb, co-segregating with marker T2. Sequence analysis of the 24 kb region revealed that an ABC transporter and a basal transcription factor (TFIIa) were potential candidates for the xa5 resistance gene product. The molecular mechanism by which the xa5 gene provides recessive, race-specific resistance to bacterial blight will be elucidated by the functional tests of the 24 kb DNA and the candidate genes.

  11. L’éducation, un bien commun très particulier

    OpenAIRE

    Proulx, Jean-Pierre

    2015-01-01

    Dans ce texte, le président du Conseil supérieur de l’éducation discute de celle-ci en tant que bien commun, mais également en tant que bien particulier. Il démontre l’importance du rôle de l’État en matière d’accessibilité à l’éducation. Ainsi, en pratique, seul l’État, en tant que responsable premier du bien commun et de la justice distributive, est capable d’assurer cette accessibilité à tous et en pleine égalité, grâce aux impôts et aux taxes qu’il perçoit des citoyens et des entreprises....

  12. Basis for the Specificity and Activation of the Serpin Protein Z-dependent Proteinase Inhibitor (ZPI) as an Inhibitor of Membrane-associated Factor Xa

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xin; Dementiev, Alexey; Olson, Steven T.; Gettins, Peter G.W. (UIC)

    2012-12-13

    The serpin ZPI is a protein Z (PZ)-dependent specific inhibitor of membrane-associated factor Xa (fXa) despite having an unfavorable P1 Tyr. PZ accelerates the inhibition reaction {approx}2000-fold in the presence of phospholipid and Ca{sup 2+}. To elucidate the role of PZ, we determined the x-ray structure of Gla-domainless PZ (PZ{sub {Delta}GD}) complexed with protein Z-dependent proteinase inhibitor (ZPI). The PZ pseudocatalytic domain bound ZPI at a novel site through ionic and polar interactions. Mutation of four ZPI contact residues eliminated PZ binding and membrane-dependent PZ acceleration of fXa inhibition. Modeling of the ternary Michaelis complex implicated ZPI residues Glu-313 and Glu-383 in fXa binding. Mutagenesis established that only Glu-313 is important, contributing {approx}5-10-fold to rate acceleration of fXa and fXIa inhibition. Limited conformational change in ZPI resulted from PZ binding, which contributed only {approx}2-fold to rate enhancement. Instead, template bridging from membrane association, together with previously demonstrated interaction of the fXa and ZPI Gla domains, resulted in an additional {approx}1000-fold rate enhancement. To understand why ZPI has P1 tyrosine, we examined a P1 Arg variant. This reacted at a diffusion-limited rate with fXa, even without PZ, and predominantly as substrate, reflecting both rapid acylation and deacylation. P1 tyrosine thus ensures that reaction with fXa or most other arginine-specific proteinases is insignificant unless PZ binds and localizes ZPI and fXa on the membrane, where the combined effects of Gla-Gla interaction, template bridging, and interaction of fXa with Glu-313 overcome the unfavorability of P1 Tyr and ensure a high rate of reaction as an inhibitor.

  13. Los bienes prestados: Estrategias feudales de consolidación señorial

    OpenAIRE

    Jular Pérez-Alfaro, Cristina

    1999-01-01

    Este artículo analiza las operaciones denominadas prestimonia en los textos medievales: un tipo particular de cesión de bienes, principalmente de tierras, realizada en calidad de préstamo de por vida, por una autoridad señorial a otra entidad y sirviendo el usufructo de los bienes concedidos como pago de lo adquirido. Tema con cierta tradición historiográfica, se pretende ahora someterlo a un nuevo cuestionario, introducirlo en la conceptualización amplia de "lo prestado" y ver resultados con...

  14. bien reconocida

    Directory of Open Access Journals (Sweden)

    N. Prat

    2015-01-01

    Full Text Available En el año 2014 se conmemora el décimo aniversario de la muerte del Profesor Ramón Margalef. En este artículo se hace un repaso a las publicaciones realizadas por el Dr. Margalef, que llegan a un total de 563 trabajos. La temática dominante de los mismos es la ecología acuática, tanto marina como de agua dulce, y mayormente centrados en los estudios de plancton. Sus trabajos están sobre todo publicados en castellano, en catalán y, en menor medida en inglés, en casi 100 revistas diferentes de todo tipo (desde revistas divulgativas a científicas. Destacan por número los artículos publicados en las revistas “Investigación Pesquera” y “Publicaciones del Instituto de Biología Aplicada”, aunque numéricamente los capítulos de libros y las actas de congresos dominan sus trabajos. De todos estos trabajos, 383 se encuentran citados en la “Web of Science” con un promedio cercano a las 100 citas por año, destacando su trabajo de 1978 sobre las formas de vida del fitoplancton, que sigue siendo muy citado (más de 50 citas por año y con tendencia incluso a crecer en el tiempo. Es destacable el poco conocimiento que se tiene de sus libros (con excepción del primero que publicó en inglés titulado “Perspectives in Ecological Theory”, de 1968. A pesar del gran reconocimiento internacional que tuvo Margalef en vida, hoy en día parece que su obra es en gran parte desconocida por los ecólogos del siglo XXI. Su nombre ha desaparecido de los libros de texto de ecología y una de sus grandes aportaciones a la ecología moderna (introducir la teoría de la información en Ecología y el índice de Shannon-Weaver como medida de diversidad no aparece en los manuales de ecología.

  15. VALORACIÓN ECONÓMICA DE BIENES AMBIENTALES POR BENEFICIARIOS CIRCUNDANTES Y NO CIRCUNDANTES

    Directory of Open Access Journals (Sweden)

    Mauricio G Villena

    2013-06-01

    Full Text Available La pregunta básica de investigación detrás de este trabajo es cómo difiere la valoración económica de un bien ambiental considerando beneficiarios circundantes (quienes viven cerca del bien en cuestión y no circundantes (quienes habitando el país donde se encuentra el bien, viven en poblaciones distantes y por tanto disfrutan esporádicamente de los beneficios provistos por el bien ambiental. En particular, en este documento se valora económicamente el Bosque de Algarrobos de la comunidad de Tiataco (Bolivia, realizando un análisis comparativo entre beneficiarios circundantes (familias residentes en la comunidad de Tiataco y beneficiarios no circundantes (familias residentes en la ciudad de Cochabamba, a 35 Km de Tiataco, a través del Método de Valoración Contingente con formato binario. Se estimaron medidas de cambio en el bienestar para ambos grupos, empleando estimaciones paramétricas y no paramétricas. Posteriormente, estas medidas se compararon estadísticamente por medio de la construcción de intervalos de confianza (entre estimaciones paramétricas y no paramétricas de cada población y entre ambas poblaciones. Por último, se identificaron los componentes del valor económico total que los beneficiarios tanto circundantes como no circundantes asignaron al bosque.

  16. Notas sobre Pasinetti, los bienes autoreproducibles y el “factor” trabajo

    OpenAIRE

    Alfons Barceló

    2006-01-01

    Esta nota pretende mostrar que son insatisfactorios los supuestos asumidos por Pasinetti sobre a) la presunta irrelevancia económica de las tasas propias de reproducción de los bienes autorreproducibles; b) la conceptualización del “trabajo” como “factor último de la producción”.

  17. Repensando los bienes comunes: análisis socio-técnico sobre la construcción y regulación de los bienes comunes

    Directory of Open Access Journals (Sweden)

    Ariel Vercelli

    2008-09-01

    Full Text Available El presente artículo analiza los bienes comunes desde una perspectiva socio-técnica. Puntualmente, invita a repensarlos en función de algunos cambios tecnológicos recientes. A partir de esta perspectiva es posible observar cómo los bienes comunes son parte de un proceso continuo de luchas, negociaciones y redefiniciones políticas entre diferentes grupos de actores. Analiza como estas luchas políticas son parte de un proceso de co-construcción entre el diseño tecnológico y las nuevas formas de regulación.This article discusses the commons ("common goods" from a socio-technical view. Specifically, it invites us to rethink them in the light of some recent technological changes. From this perspective it is possible to see how the commons are part of a continuous process of struggles, negotiations and political re-definitions among different groups of players. Analyze how these political struggles are part of a process of co-construction between the design of technologies and new forms of regulation.

  18. Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor

    Directory of Open Access Journals (Sweden)

    Upreti VV

    2013-04-01

    Full Text Available Vijay V Upreti,1 Yan Song,1 Jessie Wang,2 Wonkyung Byon,3 Rebecca A Boyd,3 Janice M Pursley,4 Frank LaCreta,1 Charles E Frost1 1Clinical Pharmacology and Pharmacometrics, Discovery Medicine and Clinical Pharmacology, 2Exploratory Development Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ, 3Primary Care Clinical Pharmacology, Pfizer, Groton, CT, 4Analytical and Bioanalytical Department, Bristol-Myers Squibb, Princeton, NJ, USA Background: Apixaban is an oral, selective, direct factor Xa inhibitor approved for thromboprophylaxis after orthopedic surgery and stroke prevention in patients with atrial fibrillation, and under development for treatment of venous thromboembolism. This study investigated the effect of a gastric acid suppressant, famotidine (a histamine H2-receptor antagonist, on the pharmacokinetics of apixaban in healthy subjects. Methods: This two-period, two-treatment crossover study randomized 18 healthy subjects to receive a single oral dose of apixaban 10 mg with and without a single oral dose of famotidine 40 mg administered 3 hours before dosing with apixaban. Plasma apixaban concentrations were measured up to 60 hours post-dose and pharmacokinetic parameters were calculated. Results: Famotidine did not affect maximum apixaban plasma concentration (Cmax or area under the plasma concentration-time curve from zero to infinite time (AUC∞. Point estimates for ratios of geometric means with and without famotidine were close to unity for Cmax (0.978 and AUC∞ (1.007, and 90% confidence intervals were entirely contained within the 80%–125% no-effect interval. Administration of apixaban alone and with famotidine was well tolerated. Conclusion: Famotidine does not affect the pharmacokinetics of apixaban, consistent with the physicochemical properties of apixaban (lack of an ionizable group and pH-independent solubility. Apixaban pharmacokinetics would not be affected by an increase in gastrointestinal pH due to

  19. Santé et biens communs : un regard de juriste.

    Directory of Open Access Journals (Sweden)

    Isabelle Moine-Dupuis

    2010-11-01

    Full Text Available La santé constitue un domaine dans lequel les notions de bien commun ou de bien public mondial sont particulièrement pertinentes. Il faut cependant préciser de quels biens il est question. A titre d’exemple, le droit français comporte des notions susceptibles de qualifier le droit aux soins (comme droit inaliénable, ou le médicament, objet de propriété intellectuelle comme de propriété « traditionnelle ». Un droit international des biens de santé peut de la même manière être fondé sur un droit d’usage de chacun sur la molécule qui est la même dans le médicament générique et celui de marque. Une procédure d’accès équivalent aux produits, brevetés ou non, pourrait être mise en œuvre par principe dès la découverte, afin de parvenir rapidement à des prix équitables.Health is a field particularly suitable for notions as commons or public goods. It is necessary however to know which goods may be concerned. For instance, French lawyers use concepts which can be used in order to qualify right to care (as an inalienable right, or medicine as an object of intellectual property as well as “traditional” one. An international law for health goods could be also based on a right of use for each person on the molecule which is the same in the generic drug or in the patented one. A process of “equivalent access” to licensed or free products could be initiated, from the discovery itself to the use, in order to obtain rapidly fair prices.

  20. Sobre el desarrollo de la teoría de los bienes públicos locales

    Directory of Open Access Journals (Sweden)

    Miltón Samuel Camelo

    2015-12-01

    Full Text Available La teoría de los bienes públicos locales toma forma desde la concepciónde la hipótesis de Tiebout, que es el primer planteamiento que tuvo en cuentala dimensión espacial de los bienes públicos, y constituye un mecanismo para la revelación de las preferencias sobre este tipo de bienes. Este trabajo desarrolla la analogía entre el modelo de Tiebout y el modelo neoclásico como una herramienta de dirección del trabajo y no como fin mismo pues, de lo contrario, puede terminar en una discusión ideológica que no es pertinente. Se examina el desarrollo de la teoría a través de la revisión de tópicos relevantes y aportes que han enriquecido y complementado el modelo de Tiebout; y, finalmente, describe elementos esenciales que debe incorporar la teoría para que tenga un mayor poder explicativo.

  1. 争奇斗艳——丰田改装车Scion xA speedster

    Institute of Scientific and Technical Information of China (English)

    志华

    2006-01-01

    世界上的车展纷繁众多,有个叫SEMA的车展每年固定在赌城拉斯维加斯举行,车展的主题就是一个字:“怪”!丰田的这款Scion xA speedster就是其中之一小怪车。

  2. Spitzer IRS Observations of the XA Region in the Cygnus Loop Supernova Remnant

    CERN Document Server

    Sankrit, R; Bautista, M; Gaetz, T J; Williams, B J; Blair, W P; Borkowski, K J; Long, K S

    2014-01-01

    We report on spectra of two positions in the XA region of the Cygnus Loop supernova remnant obtained with the InfraRed Spectrograph on the Spitzer Space Telescope. The spectra span the 10-35 micron wavelength range, which contains a number of collisionally excited forbidden lines. These data are supplemented by optical spectra obtained at the Whipple Observatory and an archival UV spectrum from the International Ultraviolet Explorer. Coverage from the UV through the IR provides tests of shock wave models and tight constraints on model parameters. Only lines from high ionization species are detected in the spectrum of a filament on the edge of the remnant. The filament traces a 180 km/s shock that has just begun to cool, and the oxygen to neon abundance ratio lies in the normal range found for Galactic H II regions. Lines from both high and low ionization species are detected in the spectrum of the cusp of a shock-cloud interaction, which lies within the remnant boundary. The spectrum of the cusp region is mat...

  3. Contemporary developments in the discovery of selective factor Xa inhibitors: A review.

    Science.gov (United States)

    Patel, Nirav R; Patel, Dushyant V; Murumkar, Prashant R; Yadav, Mange Ram

    2016-10-01

    Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized world. Venous thromboembolism is observed in about 1 million people every year in United States causing significant morbidity and mortality. Conventional antithrombotic therapy has been reported to have several disadvantages and limitations like inconvenience in oral administration, bleeding risks (heparin analogs), narrow therapeutic window and undesirable interactions with food and drugs (vitamin K antagonist-warfarin). The unmet medical demand for orally active safe anticoagulants has generated widespread interest among the medicinal chemists engaged in this field. To modulate blood coagulation, various enzymes involved in the coagulation process have received great attention as potential targets by various research groups for the development of oral anticoagulants. Among these enzymes, factor Xa (FXa) has remained the centre of attention in the last decade. Intensive research efforts have been made by various research groups for the development of small, safe and orally bioavailable FXa inhibitors. This review is an attempt to compile the research work of various researchers in the direction of development of FXa inhibitors reported since 2010 onward. PMID:27322757

  4. Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting

    Science.gov (United States)

    Zhu, Yuanjun; Li, Ruyi; Lin, Yuan; Shui, Mengyang; Liu, Xiaoyan; Chen, Huan; Wang, Yinye

    2016-01-01

    Targeted delivery of antithrombotic drugs centralizes the effects in the thrombosis site and reduces the hemorrhage side effects in uninjured vessels. We have recently reported that the platelet-targeting factor Xa (FXa) inhibitors, constructed by engineering one Arg-Gly-Asp (RGD) motif into Ancylostoma caninum anticoagulant peptide 5 (AcAP5), can reduce the risk of systemic bleeding than non-targeted AcAP5 in mouse arterial injury model. Increasing the number of platelet-binding sites of FXa inhibitors may facilitate their adhesion to activated platelets, and further lower the bleeding risks. For this purpose, we introduced three RGD motifs into AcAP5 to generate a variant NR4 containing three platelet-binding sites. NR4 reserved its inherent anti-FXa activity. Protein-protein docking showed that all three RGD motifs were capable of binding to platelet receptor αIIbβ3. Molecular dynamics simulation demonstrated that NR4 has more opportunities to interact with αIIbβ3 than single-RGD-containing NR3. Flow cytometry analysis and rat arterial thrombosis model further confirmed that NR4 possesses enhanced platelet targeting activity. Moreover, NR4-treated mice showed a trend toward less tail bleeding time than NR3-treated mice in carotid artery endothelium injury model. Therefore, our data suggest that engineering multiple binding sites in one recombinant protein is a useful tool to improve its platelet-targeting efficiency. PMID:27432161

  5. Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting.

    Science.gov (United States)

    Zhu, Yuanjun; Li, Ruyi; Lin, Yuan; Shui, Mengyang; Liu, Xiaoyan; Chen, Huan; Wang, Yinye

    2016-01-01

    Targeted delivery of antithrombotic drugs centralizes the effects in the thrombosis site and reduces the hemorrhage side effects in uninjured vessels. We have recently reported that the platelet-targeting factor Xa (FXa) inhibitors, constructed by engineering one Arg-Gly-Asp (RGD) motif into Ancylostoma caninum anticoagulant peptide 5 (AcAP5), can reduce the risk of systemic bleeding than non-targeted AcAP5 in mouse arterial injury model. Increasing the number of platelet-binding sites of FXa inhibitors may facilitate their adhesion to activated platelets, and further lower the bleeding risks. For this purpose, we introduced three RGD motifs into AcAP5 to generate a variant NR4 containing three platelet-binding sites. NR4 reserved its inherent anti-FXa activity. Protein-protein docking showed that all three RGD motifs were capable of binding to platelet receptor αIIbβ3. Molecular dynamics simulation demonstrated that NR4 has more opportunities to interact with αIIbβ3 than single-RGD-containing NR3. Flow cytometry analysis and rat arterial thrombosis model further confirmed that NR4 possesses enhanced platelet targeting activity. Moreover, NR4-treated mice showed a trend toward less tail bleeding time than NR3-treated mice in carotid artery endothelium injury model. Therefore, our data suggest that engineering multiple binding sites in one recombinant protein is a useful tool to improve its platelet-targeting efficiency. PMID:27432161

  6. Characterization of Xanthomonas oryzae-Responsive cis-Acting Element in the Promoter of Rice Race-Specific Susceptibility Gene Xa13

    Institute of Scientific and Technical Information of China (English)

    Ting Yuan; Xianghua Li; Jinghua Xiao; Shiping Wang

    2011-01-01

    The rice Xa13 gene,whose promoter harbors a UPT (up-regulated by transcription activator-like [TAL] effector) box,UPTPthXo1,plays a pivotal role in the race-specific pathogenicity caused by Xanthomonas oryzae pv. Oryzae (Xoo) strain PXO99. PXO99 causes rice disease by inducing Xa13. It is unknown,however,whether the UPTPthXo1 box is the only PXO99-responsive c/s-regulating elements in the activation of Xa13 expression. We analyzed the expression of a series of end- and site-truncated and site-mutated Xa 13 promoters in rice and the binding of PXO99 protein to the intact,partial,or site-mutated UPTPthXo1 boxes. In the Xa13 promoter,UPTPthXo1 box is the only Xoo-responsive cis-acting element that results in PXO99-induced Xa13 expression. The 5'-terminal second,third,and fourth nucleotides of the box are important for bacterial protein binding and gene activation;mutation of any one of these sites abolished PXO99-induced gene expression. Furthermore,the 3'-half of the UPTPthXo1 box is also required for protein binding and gene activation. These findings will enhance our understanding of the molecular mechanism of the interaction of rice and Xoo via UPT boxes and TAL effectors.

  7. OF THE COMMON GOOD TO THE COMMON GOOD OF HUMANITY. DE LOS BIENES COMUNES AL BIEN COMÚN DE LA HUMANIDAD.

    Directory of Open Access Journals (Sweden)

    François Houtart.

    2014-06-01

    éndum sobre el agua (uno de los bienes comunes en Italia, la Fundación Rosa Luxemburgo tomó la decisión de organizar una Conferencia sobre el concepto del Bien Común de la Humanidad, para promover una reflexión sobre los vínculos entre las dos nociones y de integrar las reivindicaciones y las luchas sociales para un cambio de sociedad, escenario en el que se enmarca éste artículo.

  8. Spitzer IRS observations of the XA region in the cygnus loop supernova remnant

    Energy Technology Data Exchange (ETDEWEB)

    Sankrit, Ravi [SOFIA Science Center, NASA Ames Research Center, M/S N211-3, Moffett Field, CA 94035 (United States); Raymond, John C.; Gaetz, Terrance J. [Smithsonian Astrophysical Observatory, 60 Garden Street, MS 15, Cambridge, MA 02138 (United States); Bautista, Manuel [Department of Physics, Western Michigan University, Kalamazoo MI 49008-5252 (United States); Williams, Brian J. [Goddard Space Flight Center, Mail Code 662, Greenbelt, MD 20771 (United States); Blair, William P. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Borkowski, Kazimierz J. [North Carolina State University, Raleigh, NC 27607 (United States); Long, Knox S. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2014-05-20

    We report on spectra of two positions in the XA region of the Cygnus Loop supernova remnant obtained with the InfraRed Spectrograph on the Spitzer Space Telescope. The spectra span the 10-35 μm wavelength range, which contains a number of collisionally excited forbidden lines. These data are supplemented by optical spectra obtained at the Whipple Observatory and an archival UV spectrum from the International Ultraviolet Explorer. Coverage from the UV through the IR provides tests of shock wave models and tight constraints on model parameters. Only lines from high ionization species are detected in the spectrum of a filament on the edge of the remnant. The filament traces a 180 km s{sup –1} shock that has just begun to cool, and the oxygen to neon abundance ratio lies in the normal range found for Galactic H II regions. Lines from both high and low ionization species are detected in the spectrum of the cusp of a shock-cloud interaction, which lies within the remnant boundary. The spectrum of the cusp region is matched by a shock of about 150 km s{sup –1} that has cooled and begun to recombine. The post-shock region has a swept-up column density of about 1.3 × 10{sup 18} cm{sup –2}, and the gas has reached a temperature of 7000-8000 K. The spectrum of the Cusp indicates that roughly half of the refractory silicon and iron atoms have been liberated from the grains. Dust emission is not detected at either position.

  9. Structure-guided creation of AcAP5-derived and platelet targeted factor Xa inhibitors.

    Science.gov (United States)

    Zhu, Yuanjun; Lin, Yuan; Liu, Aihua; Shui, Mengyang; Li, Ruyi; Liu, Xiaoyan; Hu, Wenhui; Wang, Yinye

    2015-06-15

    Anticoagulants and anti-platelet agents are simultaneously administrated in clinical practice (i.e. percutaneous coronary intervention), which cause significant risk of systemic bleeding. Targeted delivery of anticoagulants to the activated platelets at sites of vascular injuries may condense the site-specific anticoagulant effect and reduce the hemorrhage side effects in uninjured vessels. To this end, we prepared three ancylostoma caninum anticoagulant peptide 5 (AcAP5) variants NR1, NR2 and NR3 engineered with a platelet-binding Arg-Gly-Asp (RGD) motif and evaluated their anti-Factor Xa (FXa) and platelet-binding effects. These RGD-containing AcAP5 variants were capable of interacting with platelet receptor αIIbβ3 as shown in computational analysis. All variants, especially NR2 and NR3, retained entirely the anti-FXa function of parent AcAP5. Moreover, they prevented the formation of occlusive thrombi in rat carotid artery injury model, suggesting that they inhibit platelet aggregation in vivo. Further functional investigation of NR3 demonstrated that NR3 inhibited platelet aggregation in vitro and FXa activity in vivo, and prolonged the coagulation time, all in a dose-dependent manner. Through flow cytometry assay, we confirmed the binding of NR3 to αIIbβ3 receptor. In mouse model of carotid artery endothelium injury, NR3-treated mice showed less tail bleeding time than AcAP5-treated mice, and aspirin plus NR3 treatment exhibited moderate reduction of blood loss compared with aspirin plus AcAP5 treatment. These results indicate the feasibility to engineer a novel FXa inhibitor specifically targeting the activated platelets, which centralizes its anticoagulation efficacy in the injured vascular endothelium and reduces the risk of systemic bleeding. PMID:25887920

  10. Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

    Directory of Open Access Journals (Sweden)

    Liveri Angeliki

    2010-01-01

    Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

  11. Adolescentes intelectualmente bien dotados. Una investigación en la provincia de Toledo.

    OpenAIRE

    Hume Figueroa, Miriam; Sánchez Núñez, María Trinidad

    2004-01-01

    Este artículo sintetiza los resultados de una investigación sobre identificación de alumnos intelectualmente bien dotados de 1º de E.S.O. en la provincia de Toledo, que comienza en mayo de 1993 y que todavía está en curso. Mediante el método de filtrado o screening aplicamos la prueba Matrices Progresivas de Raven a casi 6.000 alumnos del curso mencionado. Escogimos la franja de alumnos que se situaba muy por encima de la media, según los resultados de dicha prueba, para realizar un estudio m...

  12. Restauración del capital natural: sin reservas no hay bienes ni servicios

    OpenAIRE

    Aronson, James; Renison, Daniel; Rangel Churio, Jesús Orlando; Levy Tacher, Samuel; Ovalle Molina, Carlos; Pozo Lira, Alejandro del

    2007-01-01

    Una de las ideas más innovadoras y atractivas que se están acuñando en la actualidad está relacionada con la necesidad que tiene la humanidad de preservar y manejar los recursos naturales - o capital natural - remanente e invertir en la restauración del capital natural (RCN) degradado para reincorporarlo a la cadena de bienes y servicios que la sociedad requiere. En este artículo, presentamos definiciones y conceptos básicos, para mostrar como la RCN es un enfoque más amplio en re...

  13. Restauración del Capital Natural: sin reservas no hay bienes ni servicios

    OpenAIRE

    Aronson, J.; D. Renison; Rangel-Ch, J. O.; S. Levy-Tacher; Ovalle, C.; del Pozo, A.

    2007-01-01

    Una de las ideas más innovadoras y atractivas que se están acuñando en la actualidad está relacionada con la necesidad que tiene la humanidad de preservar y manejar los recursos naturales o capital natural - remanente e invertir en la restauración del capital natural (RCN) degradado para reincorporarlo a la cadena de bienes y servicios que la sociedad requiere. En este artículo, presentamos definiciones y conceptos básicos, para mostrar como la RCN es un enfoque más amplio en relación al pr...

  14. El reconocimiento de los bienes de dominio público: El caso de los municipios portugueses

    Directory of Open Access Journals (Sweden)

    Susana Catarino Rua

    2016-02-01

    Full Text Available Objeto: Este trabajo tiene por objetivos analizar el mencionado en el POCAL (1999, en las NICSP del IPSASB y en diversas opiniones doctrinales con respecto al reconocimiento de los bienes de dominio público (BDP, así como verificar si existen problemas inherentes al reconocimiento de los BDP en Portugal, superables con la adopción de las NICSP. Diseño/metodología/Enfoque: Para este estudio, fue efectuada una revisión de literatura, de la posición del POCAL (1999, de las NICSP del IPSASB, y de la perspectiva doctrinal, con respecto al reconocimiento de los bienes de dominio público. Además, se realizó un estudio de la evolución de los valores de los bienes de dominio público, de los años 2006 a 2013, del total de los 308 municipios portugueses, para concluir acerca de la existencia de dificultades en el reconocimiento de estos activos y de la necesidad de adoptar los normativos internacionales. Aportaciones y Resultados: En algunos municipios portugueses, el proceso de inventario aún no está concluido, existiendo dificultades con respecto al reconocimiento de los BDP. Dichas dificultades resultan de que el POCAL (1999 no presenta los requisitos para el reconocimiento de los activos; problema superado en la NICSP nº 17 del IPSASB (2006b, que refiere esos requisitos. Adoptar un nuevo Sistema de Normalización Contable aplicable a la Administración Pública (SNC-AP, basado en las NICSP, puede ser la solución para dichas cuestiones, introduciendo criterios a considerar en el reconocimiento de los activos, que aseguren la comparabilidad de la información y de los valores del patrimonio de los municipios portugueses. Limitaciones: La inexistencia de criterios de reconocimiento a seguir por los municipios trae limitaciones al nivel de la comparabilidad de los valores de los diferentes componentes del activo presentados por los varios municipios. Valor añadido: Este trabajo nos enseña que, en Portugal, aún existen problemas con

  15. La protección transfronteriza de los bienes inmateriales en el comercio internacional

    OpenAIRE

    De Miguel Asensio, Pedro Alberto

    2008-01-01

    RESUMEN Pese a los logros de los convenios internacionales en materia de propiedad industrial e intelectual, no se ha superado el modelo basado en la territorialidad. La creciente complejidad de las actividades de explotación e infracción de los bienes inmateriales y su alcance típicamente internacional han contribuido a acentuar el debate sobre la revisión de su tratamiento en los sistemas de Derecho internacional privado, al tiempo que han dado lugar a un interés por desarrollar estánda...

  16. Determinantes de los precios internacionales de los bienes básicos

    OpenAIRE

    Carolina Arteaga; Joan Granados; Jair Ojeda

    2012-01-01

    En este trabajo se analiza la respuesta dinámica de los precios de los bienes básicos más relevantes para la evolución de la inflación en Colombia ante choques en un conjunto de sus determinantes. El documento está basado en modelos VAR estructurales en los cuales los choques exógenos son identificados mediante restricciones a los efectos contemporáneos entre las variables del sistema. Para la estimación se utilizan datos trimestrales para el periodo 1980q1 a 2010q3. De acuerdo con los result...

  17. Memoria sobre la Red de Estudio y Enseñanza Interdisciplinar del Gobierno del Bien Común

    OpenAIRE

    Ortiz García, Mercedes; Garay Montañez, Nilda; Gómez Calvo, Verónica; Hidalgo Moratal, Moisés; Carmen PASTOR SEMPERE; Romero-Tarín, Adela

    2015-01-01

    El presente trabajo en red docente ha servido para cuestionar y proponer la reformulación de la enseñanza y la investigación universitaria a partir del “gobierno del bien común”. Desde la Red se ha pretendido reformular el concepto de “bien público” como “bien común” para recalcar el uso común de dichos bienes y la necesidad de su conservación en buen estado para asegurar dicho uso, y evitar las peligrosas “privatizaciones encubiertas”. De ahí que nuestra Red a través de sus distintas discipl...

  18. Restauración del Capital Natural: sin reservas no hay bienes ni servicios

    Directory of Open Access Journals (Sweden)

    J. Aronson

    2007-01-01

    Full Text Available Una de las ideas más innovadoras y atractivas que se están acuñando en la actualidad está relacionada con la necesidad que tiene la humanidad de preservar y manejar los recursos naturales o capital natural - remanente e invertir en la restauración del capital natural (RCN degradado para reincorporarlo a la cadena de bienes y servicios que la sociedad requiere. En este artículo, presentamos definiciones y conceptos básicos, para mostrar como la RCN es un enfoque más amplio en relación al propuesto en la restauración ecológica de ecosistemas naturales. Damos a conocer estudios de caso, como ejemplos del enfoque de la RCN, y su impacto sobre el suministro de bienes y servicios en Argentina, Colombia, México y Chile. Terminamos con una breve discusión y algunas recomendaciones para la investigación y el desarrollo de la RCN a nivel local, regional y global.

  19. Vite et bien 1 A1/A2 : méthode rapide pour adultes

    CERN Document Server

    Miquel, Claire

    2009-01-01

    Vite et bien s'adresse à des adultes pressés et impatients de communiquer avec succès en français ! Le vocabulaire est simple et usuel et les thèmes, variés, pour faire face, efficacement, à toutes les situations de la vie quotidienne et professionnelle. Livre + CD audio et corrigés inclus. La méthode rapide Vite et bien 1 permet à la fois d'apprendre le français et de découvrir la réalité de la vie en France, les différences culturelles, le langage de la vie quotidienne, le tout en un temps record. En effet, le premier volume couvre, en vingt unités, les niveaux A1 et A2 du Cadre Européen de référence (CECR). Ainsi, en 100 à 120 heures de cours selon les publics, il sera possible d'acquérir une bonne base de grammaire et de vocabulaire, claire, simple, fonctionnelle, et de se sentir à l'aise dans la communication orale et écrite. L'ouvrage s'adresse aux vrais et et aux faux débutants, constituant donc un outil d'apprentissage et/ou de rafraîchissement des connaissances. Chacune des v...

  20. Musique du mal, musique du bien dans le théâtre baroque

    OpenAIRE

    Wolf, Robert Erich

    2012-01-01

    Si on cherche le fondement moral commun à la plupart des pièces de théâtre baroques, on le trouvera, il me semble, dans le conflit entre le Bien et le Mal. À l’époque baroque ce conflit prend la forme du débat, du dialogue, de la dialectique ; et, comme il arrive souvent dans l’art, l’opposition entre valeurs morales - ou psychologiques, ce qui au théâtre est équivalent - détermine en grande partie la forme de la pièce : on peut dire même qu’elle forme la pièce. Ce qui distingue l’art théâtra...

  1. Aux vrais beaux biens : souvenirs autour de Max Ophuls

    OpenAIRE

    Müller, Martina

    2007-01-01

    En 1989 j’ai interrogé des collaborateurs de Max Ophuls qui avaient travaillé avec lui au théâtre, à la radio et au cinéma. Ces entretiens ont été enregistrés pour mon documentaire de quatre-vingt dix minutes : Max Ophuls. Aux vrais beaux biens, produit par la Westdeutscher Rundfunk, télévision allemande de Cologne. Cette émission – diffusée en 1990 et jamais présenté en France – est composée d’interviews et de commentaires de séquences. En outre on y entend la voix de Max Ophuls et on le voi...

  2. The global warming, public goods and carbon market; Calentamiento global, bienes publicos y mercado de carbono

    Energy Technology Data Exchange (ETDEWEB)

    Quadri de la Torre, Gabriel [EcoSecurities (Mexico)

    2007-07-15

    The global warming is an issue of the public goods, and demands an outstanding multilateral action, which must to ensure both efficiency and unchanging transition towards an economy of low intensity of carbon. The new system, which is going to replace the Kyoto Protocol, will have compromises for the developing countries and deep implication in the relative competitivity of the nations and companies. [Spanish] El calentamiento global es un problema de bienes publicos que exige una extraordinaria accion multilateral. Esta debe asegurar eficiencia y una transicion fluida hacia una economia de baja intensidad de carbono. El nuevo sistema que sucedera al Protocolo de Kyoto significara compromisos para los paises en vias de desarrollo, y tendra profundas implicaciones en la competitividad relativa de naciones y empresas.

  3. Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

    International Nuclear Information System (INIS)

    Coagulation Factor (F)Xa is a serine protease that plays a crucial role during blood coagulation by converting prothrombin into active thrombin. Recently, however, it emerged that besides this role in coagulation, FXa induces intracellular signaling leading to different cellular effects. Here, we show that coagulation factor (F)Xa drives tumor cells of epithelial origin, but not endothelial cells or monocytes, into apoptosis, whereas it even enhances fibroblast survival. FXa signals through the protease activated receptor (PAR)-1 to activate extracellular-signal regulated kinase (ERK) 1/2 and p38. This activation is associated with phosphorylation of the transcription factor CREB, and in tumor cells with up-regulation of the BH3-only pro-apoptotic protein Bim, leading to caspase-3 cleavage, the main hallmark of apoptosis. Transfection of tumor cells with dominant negative forms of CREB or siRNA for either PAR-1, Bim, ERK1 and/or p38 inhibited the pro-apoptotic effect of FXa. In fibroblasts, FXa-induced PAR-1 activation leads to down-regulation of Bim and pre-treatment with PAR-1 or Bim siRNA abolishes proliferation. We thus provide evidence that beyond its role in blood coagulation, FXa plays a key role in cellular processes in which Bim is the central player in determining cell survival

  4. Oral IIa and Xa inhibitors for prevention of stroke in atrial fibrillation: clinical studies and regulatory considerations.

    Science.gov (United States)

    Deftereos, Spyridon; Tsounis, Dimitrios; Giannopoulos, Georgios; Kossyvakis, Charalampos; Panagopoulou, Vasiliki; Raisakis, Konstantinos; Stefanadis, Christodoulos

    2012-08-01

    Atrial fibrillation (AF), the most common, clinically significant, cardiac arrhythmia affects 1% of the general population and has important hemodynamic and thromboembolic complications that contribute to elevated morbidity and mortality. AF increases the overall risk of stroke five-fold, accounting for approximately 15% of all strokes and is associated with particularly severe stroke. For the last 50 years, long-term anticoagulation with vitamin K antagonists has been the most effective therapy for preventing stroke and systemic embolism in patients with AF and other risk factors, but their use has a lot of limitations and drawbacks (frequent monitoring and dose adjustment, food and drug interactions, delayed onset of action etc). Nowadays, new oral anticoagulants have emerged that seem to overcome those limitations. Direct thrombin inhibitor dabigatran and factor Xa inhibitors rivaroxaban and apixaban have proven, in large, multicenter, randomized, phase III, clinical studies, to be at least as efficient as warfarin in stroke prevention in patients with AF. RELY and ROCKET AF trials have contributed to market approval of dabigatran and rivaroxaban, respectively and made them available to clinical practice. Another factor Xa inhibitor, edoxaban, is under evaluation in an ongoing phase III clinical trial and others such as AZD0837, betrixaban and darexaban are still in safety and tolerability phase II studies. The oral anticoagulation landscape is changing rapidly and these new agents seem to be very promising. However future post-marketing studies and registries will help clarify their efficacy and safety. PMID:22564122

  5. AvrXa3:A novel member of avrBs3 gene family from Xanthomonas oryzae pv.oryzae has a dual function

    Institute of Scientific and Technical Information of China (English)

    LI Ping; LONG Juying; HUANG Yingchun; ZHANG Yan; WANG Jinsheng

    2004-01-01

    Two positive clones pUAV45 and pUAV47 were identified from the cDNA library of JxoⅢ, a race 3 strain of Xanthomonas oryzae pv. Oryzae Dye (Xoo) in Japanese system, using Tn5 based technology. pUAV45 clone contained a 25.4 kb Xoo genomic DNA insert. Southern blot analysis with avrXa10 as the probe showed that DNA insert in pUAV45 shares homology with avrX10. Furthermore within the Xoo insert, a smaller 5.7 kb KpnI fragment (pUAVSk) was identified through hybridization with avrXa10. The transformation of pUAV45 and pUAV5k into the strain Pxo99 (race 6 in Philippine system) led to the decrease of Pxo99pathogenicity on rice cultivar Wase Aikoku 3 (Xa3) and the increase of the pathogen pathogenicity on Cas209 (Xa10). The result of sequence analysis showed that there is a 2598 bp open reading frame (ORF) within the 5.7 kb Kpn 1 fragment (pUAVSk). The ORF shared high identity (97 % ) with avrXa10. The deduced sequence of the ORF contained 8.5 tandem repeat units of 34-amino-acids, one leucine zipper (LZ), three nuclear localization signal (NLS) motifs, and an acidic activation transcriptional domain (AAD) at C-terminus.We named this ORF avrXa3 and it is classified as a new member of avrBs3 (avr/pth) family with the dual-function determined by alternations of avirulence and aggressiveness on rice cultivars carrying different ‘ R' genes.

  6. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome

    DEFF Research Database (Denmark)

    Steg, Ph Gabriel; Mehta, Shamir R; Jukema, J Wouter;

    2011-01-01

    To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS).......To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS)....

  7. Problemática sobre la disponibilidad de los Bienes Jurídicos Individuales y Responsabilidades Emergentes

    OpenAIRE

    Ignacio Curbelo Solari

    2013-01-01

    Sobre el concepto de Disponibilidad. Concepto de Bien Jurídico y sus funciones. El Consentimiento. Breve Historia. Bienes Jurídicos Colectivos e Individuales. Naturaleza Jurídica del Consentimiento. Posición de Jescheck, Roxin y Muñoz Conde. Posición de los principales autores nacionales: Prof. Gonzalo Fernández, Miguel Langón, Germán Aller, Pedro Montano. Los requisitos del consentimiento. En la doctrina extranjeraEn la doctrina uruguaya El consentimiento presunto. Requisitos del consentimie...

  8. "Cooperativismo y economía del bien común" (Cooperativism and economy of the common good)

    OpenAIRE

    Alejandro Martínez Charterina

    2013-01-01

    En los últimos años (desde 2010) se está promocionando elmodelo de economía del bien común que muestra un buen número de cooperativascomo ejemplo de lo que promociona en el orden empresarial. Este trabajotrata de destacar el interés de las cooperativas por la mejora social, en general,y en particular en el medio en el que se hacen presentes, trascendiendolos intereses de cada cooperativa singular. Esto queda bien unido a las pretensionesde la Alianza Cooperativa Internacional dirigidas a la p...

  9. Programas políticos y bienes y usos comunales en Lorena durante la Revolución Francesa

    OpenAIRE

    Ríos, Manuel

    2015-01-01

    La historiografía inglesa ha ahondado en el estudio de los bienes y usos comunales con el propósito de comprender el rol que jugó la transformación de los mismos en la transición del feudalismo al capitalismo. No obstante, su contraparte francesa ha tendido a relegar este tipo de estudios a un segundo plano, sobre todo en lo que a los usos comunales respecta. De hecho, en los últimos veinte años se ha postulado la necesidad de estudiar a los bienes y usos comunales por separado, compartimenta...

  10. Transgenic expression of the rice Xa21 pattern recognition receptor in banana (Musa sp.) confers resistance to Xanthomonas campestris pv. musacearum

    Science.gov (United States)

    Tripathi, Jaindra Nath; Lorenzen, Jim; Bahar, Ofir; Ronald, Pamela; Tripathi, Leena

    2014-01-01

    Summary Banana Xanthomonas wilt (BXW), caused by the bacterium Xanthomonas campestris pv. musacearum (Xcm), is the most devastating disease of banana in east and central Africa. The spread of BXW threatens the livelihood of millions of African farmers who depend on banana for food security and income. There are no commercial chemicals, bio-control agents or resistant cultivars available to control BXW. Here we take advantage of the robust resistance conferred by the rice pattern recognition receptor (PRR), XA21, to the rice pathogen Xanthomonas oryzae pv. oryzae (Xoo). We identified a set of genes required for activation of Xa21 mediated immunity (rax) that were conserved in both Xoo and Xcm. Based on the conservation, we hypothesized that intergeneric transfer of Xa21 would confer resistance to Xcm. We evaluated 25 transgenic lines of the banana cultivar ‘Gonja manjaya’ (AAB) using a rapid bioassay and 12 transgenic plants in the glass house for resistance against Xcm. About fifty percent of the transgenic lines showed complete resistance to Xcm in both assays. In contrast, all of the non-transgenic control plants showed severe symptoms that progressed to complete wilting. These results indicate that the constitutive expression of the rice Xa21 gene in banana results in enhanced resistance against Xcm. Furthermore this work demonstrates the feasibility of PRR gene transfer between monocotyledonous species and provides a valuable new tool for controlling the BXW pandemic of banana, a staple food for 100 million people in east Africa. PMID:24612254

  11. Transgenic expression of the rice Xa21 pattern-recognition receptor in banana (Musa sp.) confers resistance to Xanthomonas campestris pv. musacearum.

    Science.gov (United States)

    Tripathi, Jaindra N; Lorenzen, Jim; Bahar, Ofir; Ronald, Pamela; Tripathi, Leena

    2014-08-01

    Banana Xanthomonas wilt (BXW), caused by the bacterium Xanthomonas campestris pv. musacearum (Xcm), is the most devastating disease of banana in east and central Africa. The spread of BXW threatens the livelihood of millions of African farmers who depend on banana for food security and income. There are no commercial chemicals, biocontrol agents or resistant cultivars available to control BXW. Here, we take advantage of the robust resistance conferred by the rice pattern-recognition receptor (PRR), XA21, to the rice pathogen Xanthomonas oryzae pv. oryzae (Xoo). We identified a set of genes required for activation of Xa21-mediated immunity (rax) that were conserved in both Xoo and Xcm. Based on the conservation, we hypothesized that intergeneric transfer of Xa21 would confer resistance to Xcm. We evaluated 25 transgenic lines of the banana cultivar 'Gonja manjaya' (AAB) using a rapid bioassay and 12 transgenic lines in the glasshouse for resistance against Xcm. About 50% of the transgenic lines showed complete resistance to Xcm in both assays. In contrast, all of the nontransgenic control plants showed severe symptoms that progressed to complete wilting. These results indicate that the constitutive expression of the rice Xa21 gene in banana results in enhanced resistance against Xcm. Furthermore, this work demonstrates the feasibility of PRR gene transfer between monocotyledonous species and provides a valuable new tool for controlling the BXW pandemic of banana, a staple food for 100 million people in east Africa. PMID:24612254

  12. Prevention of venous thromboembolism with an oral factor Xa inhibitor, YM150, after total hip arthroplasty. A dose finding study (ONYX-2)

    DEFF Research Database (Denmark)

    Eriksson, B I; Turpie, A G G; Lassen, M R;

    2010-01-01

    BACKGROUND: Anticoagulant prophylaxis substantially reduces the risk of venous thromboembolism (VTE) after major orthopedic surgery. The direct factor Xa inhibitor YM150 is currently under investigation for the prevention of VTE, stroke and ischemic vascular events in patients after orthopedic su...

  13. Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

    Czech Academy of Sciences Publication Activity Database

    Calvo, E.; Mizurini, D.M.; Sa-Nunes, A.; Ribeiro, J.M.C.; Andersen, J. F.; Mans, B.J.; Monteiro, R.Q.; Kotsyfakis, Michalis; Francischetti, I.M.B.

    2011-01-01

    Roč. 286, č. 32 (2011), 27998-28010. ISSN 0021-9258 Institutional research plan: CEZ:AV0Z60220518 Keywords : serpin * mosquito * Aedes albopictus * phospholipids * Factor Xa * heparin * binding affinity * coagulation * thrombus * bleeding Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 4.773, year: 2011

  14. Search for anomalons in interactions of neon-22 nuclei with emulsion nuclei at 4. 1xA GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Bannik, B.P.; Batusov, Y.A.; Bokova, L.N.; Vokalova, A.; Kuznetsov, O.M.; Lyukov, V.V.; Piskaleva, O.V.; Tolstov, K.D.; Tret' yak, V.I.; Shabratova, G.S.; Andreeva, N.P.; Anzon, Z.V.; Bubnov, V.I.; Gaitinov, A.S.; Eremenko, L.E.; Kalyachkina, G.S.; Kanygina, =.K.; Chasnikov, I.Y.; Gitsok, M.; Marin, A.; Roshu, H.; Haiduk, M.; Hasegan, D.; Bobodzhanov, I.; Leskin, V.A.; Mukhtarov, A.; Shermatov, S.M.; Khoshmukhamedov, R.A.; Dzhuranova, M.S.; Salomov, D.A.; Avetyan, F.A.; Krishchyan, V.M.; Marutyan, N.A.; Matevosyan, K.; Sarkisova, L.G.; Lepekhin, F.G.; Simonov, B.B.; Koraba, J.; Korabovi, M.; Silesh, E.; Wilcincka, B.; Volter, V.; Vosek, B.; Olshecki, A.; Holyncki, R.; Antonchik, V.A.; Bakaev, V.A.; Belousov, A.V.; Bogdanov, S.D.; Ostroumov, V.I.; Bogdanov, V.G.; Plyushchev, V.A.; Solov' eva, Z.I.; Adamovich, M.I.; Larionova, V.G.; Orlova, G.I.; Salmanova, N.A.; Tret' yakova, M.T.; Kharlamov, S.P.; Azimov, S.A.; Abduzhamilov, A.; Abduzhamilov, S.; Gadzhieva, S.; Gulamov, K.G.; Dzhuraev, M.

    1984-02-25

    The mean free path before an inelastic interaction of relativistic fragments of neon-22 nuclei with emulsion nuclei at a momentum of 4.1xA GeV/c is studied as a function of the distance traversed by the fragments. No such dependence is found for fragments with charges from 3 to 9.

  15. Efficient selection of homozy-gous lines of hybrid rice restorer with the transgene Xa21 using test cross and PCR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The homozygous restorer lines with a single copy of the transgene Xa21 have been obtained from the progenies of transgenic Minghui63 and Yanhui559 plants through PCR marker-assisted selection and test cross. These homozygous transgenic restorer lines can be used to breed hybrid rice with high resistance to bacterial leaf blight.

  16. El emprendimiento y el bien común: ¿competencias complementarias o excluyentes?

    Directory of Open Access Journals (Sweden)

    Juan David Enciso-Congote

    2010-04-01

    Full Text Available Este trabajo propone un análisis comparativo entre los requerimientos de la formación de competencias para el emprendimiento y para el desempeño laboral, de acuerdo con el escenario que sirve de contexto a cada una de ellas. En el caso del desempeño laboral, se toma como punto de referencia la estructura burocrática descrita por Max Weber. En cuanto al emprendimiento, las raíces son antropológicas, la naturaleza humana, independientemente de cualquier referente cultural o histórico. Estas consideraciones proporcionan un marco de referencia para reflexionar sobre las dificultades conceptuales y pedagógicas que obstaculizan la construcción de una visión más inclusiva de lo público y del compromiso que debe tener un profesional con la búsqueda del bien común y, por tanto, de la responsabilidad que recae en la formación universitaria para procurar este cometido.

  17. De las cenizas a la Red: el Periodismo como bien común

    Directory of Open Access Journals (Sweden)

    José Carlos Sendín Gutiérrez

    2014-11-01

    Full Text Available Sampedro nos ofrece y comparte –porque el libro se puede leer en partes también en la red– no sólo y fundamentalmente un alegato a favor del periodismo, sino además, una defensa de un nuevo poder ciudadano y de una nueva democracia. Desde las primeras líneas el lector se siente sacudido por el alto voltaje de los datos, los personajes y el análisis perspicaz de la transformación social que parece apuntarse, pero que hasta ahora nadie había sabido traducir en palabras. Palabras que a veces parecen querer levantar por las solapas al que lee, como diciendo, “entérate, está pasando ahora y es importante que lo descubras”, mientras desarrolla ideas a las que vuelve y recalca, pasados los capítulos, en un ejercicio circular que pretende dejar clara –y lo consigue– la tesis central: ya existe una nueva forma de periodismo entendido como bien común (sí, al igual que el agua o el aire que respiramos, libre, de código abierto y mancomunado. Aire nuevo para una sociedad desencantada, para un periodismo en busca de modelos y para unas aulas donde se forman los futuros profesionales en una universidad maltratada, pero quizá por ello, también sumida en la conformidad de un saber rutinario.

  18. Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino Acid Regions from Factor Va Heavy Chain†

    Science.gov (United States)

    2008-01-01

    The prothrombinase complex catalyzes the activation of prothrombin to α-thrombin. We have repetitively shown that amino acid region 695DYDY698 from the COOH terminus of the heavy chain of factor Va regulates the rate of cleavage of prothrombin at Arg271 by prothrombinase. We have also recently demonstrated that amino acid region 334DY335 is required for the optimal activity of prothrombinase. To assess the effect of these six amino acid residues on cofactor activity, we created recombinant factor Va molecules combining mutations at amino acid regions 334–335 and 695−698 as follows: factor V3K (334DY335 → KF and 695DYDY698 → KFKF), factor VKF/4A (334DY335 → KF and 695DYDY698 → AAAA), and factor V6A (334DY335 → AA and 695DYDY698 → AAAA). The recombinant factor V molecules were expressed and purified to homogeneity. Factor Va3K, factor VaK4/4A, and factor Va6A had reduced affinity for factor Xa, when compared to the affinity of the wild-type molecule (factor VaWt) for the enzyme. Prothrombinase assembled with saturating concentrations of factor Va3K had a 6-fold reduced second-order rate constant for prothrombin activation compared to the value obtained with prothrombinase assembled with factor VaWt, while prothrombinase assembled with saturating concentrations of factor VaKF/4A and factor Va6A had approximately 1.5-fold reduced second-order rate constants. Overall, the data demonstrate that amino acid region 334–335 together with amino acid region 695−698 from factor Va heavy chain are part of a cooperative mechanism within prothrombinase regulating cleavage and activation of prothrombin by factor Xa. PMID:18991406

  19. Comunicación política y bien común en tiempo de elecciones

    OpenAIRE

    Pérez-Latre, F.J. (Francisco Javier)

    2015-01-01

    Para que la política funcione es necesaria una comunidad de personas diversas, pero que sienten respeto y admiración mutua y coinciden en el afán de mejorar la sociedad y trabajar por el bien común.

  20. TTIP: Análisis jurídico-técnico y su impacto en el comercio de bienes

    OpenAIRE

    Aizpiri Oliván, Martín

    2016-01-01

    El TFG en cuestión trata de abordar desde una perspectiva técnico-jurídica los elementos y procedimientos para liberalizar el comercio que se plantean en el TTIP, con especial mención al comercio de bienes.

  1. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    Directory of Open Access Journals (Sweden)

    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value

  2. Bienes rústicos de aprovechamiento público en la Valencia moderna

    Directory of Open Access Journals (Sweden)

    David BERNABÉ GIL

    2009-12-01

    Full Text Available RESUMEN: Analiza el presente trabajo diversos aspectos relacionados con los derechos de aprovechamiento público que confluían en los espacios rústicos no cultivados del antiguo Reino de Valencia, así como la naturaleza de los problemas que solía suscitar su atribución dominical, dada la frecuente superposición de instancias institucionales con pretensiones de control. A partir de la compleja tipología que la casuística al respecto —aún escasa y mal conocida— permite entrever, queda en evidencia el fuerte arraigo de los elementos de regulación municipal vigentes en el realengo, si bien en franco retroceso ante los tardíos intentos de control por el Real Patrimonio. En los señoríos, sin embargo, son los derechos del titular de la jurisdicción los que consiguen prevalecer, aunque no necesariamente por exclusión de los reconocidos a la comunidad.ABSTRACT: This study analyzes different aspects related to the rights of public usage with regard to uncultivated agricultural spaces in the ancient Kingdom of Valencia, as well as the nature of the problems normally arising from the conferring of their feudal status, due to the frequent superimposing of institutional requests to gain control. With regard to the complex typology that the corresponding casuistry (still scarce and hardly known suggests, we can highlight the fact that the elements of municipal regulation that existed within the state were well-established, although they were clearly in decline in the face of the Royal Trust's late attempts to gain control. However, as regards the estates, the ownership rights of the jurisdiction were the ones that finally prevailed, although not necessarily by excluding the rights of the community.

  3. La Salud en Colombia: ¿Qué tan meritorio y público es este bien o servicio?

    Directory of Open Access Journals (Sweden)

    Carlos Arturo Meza Carvajalino

    2003-11-01

    Full Text Available La controversia en la prestación del servicio de salud en Colombia se plantea desde distintos ámbitos, tanto en las instituciones del Estado como en la esfera académica, situación que afecta el desarrollo de la política del sector de la salud, por encontrarse este servicio asociado y vinculado con los derechos económicos, sociales y culturales. Además por el desconocimiento del principio que en esencia le define como un bien que, por sus características, es meritorio. Lamentablemente, en la práctica se convierte en un bien público preferente.

  4. EL DILEMA DE LA CONTRIBUCIÓN VOLUNTARIA A BIENES PÚBLICOS: UNA REVISIÓN DE TRABAJOS EXPERIMENTALES

    Directory of Open Access Journals (Sweden)

    Luis Alejandro Palacio García

    2014-01-01

    Full Text Available El artículo presenta una revisión de los experimentos realizados sobre bienes públicos apoyados en el mecanismo de contribución voluntaria. La evidencia empírica existente muestra que los individuos no son solo los seres egoístas y competitivos que supone la teoría económica ortodoxa, sino que también son seres bondadosos y altruistas. Aunque los diversos trabajos experimentales concuerdan en la existencia de estos sentimientos catalogados como "bondad", no es claro si los sujetos actúan así para mejorar el bienestar de los demás (altruismo o porque se sienten bien realizando este tipo acciones (satisfacción moral.

  5. Bien commun, conflits d’intérêts et délibération éthique

    OpenAIRE

    Müller, Denis

    2016-01-01

    Si la notion de bien commun paraît de prime abord trop ambitieuse, trompeuse en ses promesses excessives et inaccessibles, elle est néanmoins nécessaire au débat éthique dans l’espace public contemporain. Cette contribution veut montrer comment une compréhension critique de la notion controversée de bien commun peut s’avérer compatible avec une prise en compte réaliste et responsable des conflits d’intérêts et de la délibération éthique. L’exemple du débat français sur la laïcité permet à cet...

  6. Recensión La economía del bien común, de Christian Felber

    Directory of Open Access Journals (Sweden)

    Antonio Fernández Laborda

    2014-03-01

    Full Text Available El autor propone que el sistema económico persiga el mismo fin que el establecido en las normas políticas, es decir, el bien común. Felber parte de la premisa de que las empresas compiten entre ellas y, principalmente, se preocupan por aumentar sus beneficios en su cuenta de resultados. Por ello propone que esos resultados incorporen índices relacionados con valores como el respeto a los derechos humanos, a los derechos de los trabajadores, al medio ambiente y a los valores democráticos como la cooperación entre empresas  que decide practicar esa misma entidad. Toda esta serie de nuevos índices formarían también parte del balance del bien común

  7. "Cooperativismo y economía del bien común" (Cooperativism and economy of the common good

    Directory of Open Access Journals (Sweden)

    Alejandro Martínez Charterina

    2013-01-01

    Full Text Available En los últimos años (desde 2010 se está promocionando elmodelo de economía del bien común que muestra un buen número de cooperativascomo ejemplo de lo que promociona en el orden empresarial. Este trabajotrata de destacar el interés de las cooperativas por la mejora social, en general,y en particular en el medio en el que se hacen presentes, trascendiendolos intereses de cada cooperativa singular. Esto queda bien unido a las pretensionesde la Alianza Cooperativa Internacional dirigidas a la promoción de conductasque puedan llevar a un cambio social y una economía sostenible, quereconocemos como las aspiraciones de conquista del cooperativismo.

  8. Problemática sobre la disponibilidad de los Bienes Jurídicos Individuales y Responsabilidades Emergentes

    Directory of Open Access Journals (Sweden)

    Ignacio Curbelo Solari

    2013-12-01

    Full Text Available Sobre el concepto de Disponibilidad. Concepto de Bien Jurídico y sus funciones. El Consentimiento. Breve Historia. Bienes Jurídicos Colectivos e Individuales. Naturaleza Jurídica del Consentimiento. Posición de Jescheck, Roxin y Muñoz Conde. Posición de los principales autores nacionales: Prof. Gonzalo Fernández, Miguel Langón, Germán Aller, Pedro Montano. Los requisitos del consentimiento. En la doctrina extranjeraEn la doctrina uruguaya El consentimiento presunto. Requisitos del consentimiento presunto.Relevancia del consentimiento en el Derecho Positivo. Derecho extranjero Derecho Uruguayo. Diversas situaciones. El art. 44 del CP. La Vida. El consentimiento y la responsabilidad de los médicos. Las intervenciones transexuales. La Eutanasia La ley 18.473 de Voluntad anticipada. La auto puesta en peligro.

  9. Evaluación de riesgos en el sector de fabricación de bienes de equipo

    OpenAIRE

    González Antuña, Pablo

    2013-01-01

    El propósito fundamental de este trabajo es orientar a todo el personal que trabaja en el sector de fabricación de bienes de equipo, sobre las condiciones de trabajo, las condiciones de las instalaciones a través de una evaluación de riesgos laborales presentes en las áreas de trabajo de dicho sector y sobre las medidas preventivas a adoptar para controlar el riesgo laboral

  10. Predictors for dioxin accumulation in residents living in Da Nang and Bien Hoa, Vietnam, many years after Agent Orange use.

    Science.gov (United States)

    Pham, Diem T; Nguyen, Hang M; Boivin, Thomas G; Zajacova, Anna; Huzurbazar, Snehalata V; Bergman, Harold L

    2015-01-01

    Agent Orange (AO) was the main defoliant used by the US in Vietnam from 1961 to 1971; AO was contaminated with dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD). Three major dioxin “hot spots” remain from previous AO storage and use at former US bases at Bien Hoa, Da Nang, and Phu Cat, posing potential health risks for Vietnamese living on or near these hot spots. We evaluated potential risk factors contributing to serum TCDD levels in Vietnamese residents at and near contaminated sites in Da Nang and Bien Hoa, Vietnam. We used multiple linear regression to analyze possible associations of blood dioxin concentrations with demographic, socioeconomic, lifestyle, and dietary risk factors for residents living on or near these hot spots. For the Da Nang study, fish farming on the site, living on property flooded from monsoon rains, and age were among the factors showing significant positive associations with serum TCDD concentrations. For the Bien Hoa study, fish farmers working at this site and their immediate family members had significantly higher serum TCDD concentrations. Our results suggest that water-related activities, especially fish-farming, at the hot spots increased the risk of exposure to dioxin. PMID:25463251

  11. Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.

    Science.gov (United States)

    Van Huis, Chad A; Casimiro-Garcia, Agustin; Bigge, Christopher F; Cody, Wayne L; Dudley, Danette A; Filipski, Kevin J; Heemstra, Ronald J; Kohrt, Jeffrey T; Leadley, Robert J; Narasimhan, Lakshmi S; McClanahan, Thomas; Mochalkin, Igor; Pamment, Michael; Peterson, J Thomas; Sahasrabudhe, Vaishali; Schaum, Robert P; Edmunds, Jeremy J

    2009-03-15

    Aiming to improve upon previously disclosed Factor Xa inhibitors, a series of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides were explored with the intent of increasing the projected human half-life versus 5 (projected human t(1/2)=6 h). A stereospecific route to compounds containing a 4-aryl-4-hydroxypyrrolidine scaffold was developed, resulting in several compounds that demonstrated an increase in the half-life as well as an increase in the in vitro potency compared to 5. Reported herein is the discovery of 26, containing a (2R,4S)-4-hydroxy-4-(2,4-difluorophenyl)-pyrrolidine scaffold, which is a selective, orally bioavailable, efficacious Factor Xa inhibitor that appears suitable for a once-daily dosing (projected human t(1/2)=23 h). PMID:19231206

  12. Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolated from Bauhinia ungulata seeds.

    Science.gov (United States)

    Oliva, M L; Andrade, S A; Batista, I F; Sampaio, M U; Juliano, M; Fritz, H; Auerswald, E A; Sampaio, C A

    1999-12-01

    Kunitz type Bauhinia ungulata factor Xa inhibitor (BuXI) was purified from B. ungulata seeds. BuXI inactivates factor Xa and human plasma kallikrein (HuPK) with Ki values of 18.4 and 6.9 nM, respectively. However, Bauhinia variegata trypsin inhibitor (BvTI) which is 70% homologous to BuXI does not inhibit factor Xa and is less efficient on HuPK (Ki = 80 nM). The comparison between BuXI and BvTI reactive site structure indicates differences at Met59, Thr66 and Met67 residues. The hydrolysis rate of quenched fluorescence peptide substrates based on BuXI reactive site sequence, Abz-VMIAALPRTMFIQ-EDDnp (leading peptide), by HuPK and porcine pancreatic kallikrein (PoPK) is low, but hydrolysis is enhanced with Abz-VMIAALPRTMQ-EDDnp, derived from the leading peptide shortened by removing the dipeptide Phe-Ileu from the C-terminal portion, for HuPK (Km = 0.68 microM, k(cat)/Km = 1.3 x 10(6) M(-1) s(-1)), and the shorter substrate Abz-LPRTMQ-EDDnp is better for PoPK (Km = 0.66 microM, k(cat)/Km = 2.2 x 10(3) M(-1) s(-1)). The contribution of substrate methionine residues to HuPK and PoPK hydrolysis differs from that observed with factor Xa. The determined Km and k(cat) values suggest that the substrates interact with kallikreins the same as an enzyme and inhibitor interacts to form complexes. PMID:10615004

  13. MODEL GROUP INVESTIGATION (GI) DIPADU PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKAN KETERAMPILAN BEKERJA ILMIAH DAN KEMAMPUAN KOGNITIF SISWA KELAS X-A1 SMAN 2 MALANG

    OpenAIRE

    Prasmala, Erfitra Rezqi

    2016-01-01

    ABSTRACTThe purpose of this study to improve (1) the skills of scientific work, (2) the cognitive abilities of students of class X-A1 at SMAN 2 Malang through the application of models Group Investigation (GI) combined with the Problem Based Learning (PBL). Type of research is Action Research Action (PTK) with research subjects-A1 class X SMAN 2 Malang. Data collected by the research instrument consisting of a sheet of observation skills of scientific work, scientific work reports, students' ...

  14. Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor

    OpenAIRE

    Mendell, Jeanne; Zahir, Hamim; Matsushima, Nobuko; Noveck, Robert; Lee, Frank; Chen, Shuquan; Zhang, George; Shi, Minggao

    2013-01-01

    Background Edoxaban, an oral direct factor Xa inhibitor, is in development for thromboprophylaxis, including prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). P-glycoprotein (P-gp), an efflux transporter, modulates absorption and excretion of xenobiotics. Edoxaban is a P-gp substrate, and several cardiovascular (CV) drugs have the potential to inhibit P-gp and increase drug exposure. Objective To assess the potential pharmacokinetic interactions of edoxaban...

  15. Microfluidic Chip-Based Online Screening Coupled to Mass Spectrometry: Identification of Inhibitors of Thrombin and Factor Xa.

    Science.gov (United States)

    Iyer, Janaki Krishnamoorthy; Otvos, Reka A; Kool, Jeroen; Kini, R Manjunatha

    2016-02-01

    Thrombin and factor Xa (FXa) are critical enzymes of the blood coagulation cascade and are excellent targets of anticoagulant agents. Natural sources present an array of anticoagulants that can be developed as antithrombotic drugs. High-resolution, online screening techniques have been developed for the identification of drug leads from complex mixtures. In this study, we have developed and optimized a microfluidic online screening technique coupled to nano-liquid chromatography (LC) and in parallel with a mass spectrometer for the identification of thrombin and FXa inhibitors in mixtures. Inhibitors eluting from the nano-LC were split postcolumn in a 1:1 ratio; half was fed into a mass spectrometer (where its mass is detected), and the other half was fed into a microfluidic chip (which acts as a microreactor for the online assays). With our platform, thrombin and FXa inhibitors were detected in the assay in parallel with their mass identification. These methods are suitable for the identification of inhibitors from sample amounts as low as sub-microliter volumes. PMID:26323281

  16. AutoGPA-Based 3D-QSAR Modeling and Molecular Docking Study on Factor Xa Inhibitors as Anticoagulant Agents

    Directory of Open Access Journals (Sweden)

    Guo Fang Yuan

    2016-01-01

    Full Text Available The three-dimensional-quantitative structure activity relationship (3D-QSAR studies were performed on a series of direct factor Xa (FXa inhibitors using AutoGPA-based modeling method in this paper. A training set of 38 molecules and a test set containing 10 molecules were used to build the 3D-QSAR model and validate the derived model, respectively. The developed model with correlation coefficients (r2 of 0.8564 and cross-validated correlation coefficients (q2 of 0.6721 were validated by an external test set of 10 molecules with predicted correlation coefficient (rpred2 of 0.6077. Docking study of FXa inhibitors and FXa active site was performed to check the induced pharmacophore query and comparative molecular field analysis (CoMFA contour maps using MOE2012.10. It was proved to be coincidence with the interaction information between ligand and FXa active site and was rendered to provide a useful tool to improve FXa inhibitors.

  17. Edoxaban: A Novel Factor Xa Inhibitor for the Management of Non-valvular Atrial Fibrillation and Venous Thromboembolism.

    Science.gov (United States)

    Kubli, Kara A; Snead, Jessica A; Cheng-Lai, Angela

    2016-01-01

    Warfarin has been a highly prevalent agent for over 70 years; however, its use has been limited by drug-drug interactions, adverse events, and the need for frequent monitoring. To minimize these complications, several non-vitamin K oral anticoagulants have been approved, including the latest agent, edoxaban. Edoxaban is a factor Xa inhibitor approved for the prevention of stroke/systemic embolism in patients with non-valvular atrial fibrillation and for the treatment of venous thromboembolism. Edoxaban was largely studied in the Edoxaban versus Warfarin in Patients with Atrial Fibrillation (ENGAGE AF-TIMI 48) and Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism (Hokusai-VTE) trials, both showing noninferiority when compared with warfarin. Similar to other oral anticoagulants, the most serious adverse effects of edoxaban are related to bleeding. However, there are currently no approved reversal agents. Andexanet alfa and ciraparantag are the latest agents being studied for reversal. This article provides an overview of the safety and efficacy along with the advantages and disadvantages of edoxaban. PMID:26991962

  18. Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement

    Directory of Open Access Journals (Sweden)

    Bramlage Peter

    2012-06-01

    Full Text Available Abstract Background The aim was to investigate, whether 5,000 IUaXa/day certoparin lowers the incidence of deep vein thrombosis (DVT in patients undergoing elective hip replacement surgery vs. 3,000 IUaXa/day. Double-blind, multicenter, randomised trial in 500 patients. Primary endpoint: incidence of symptomatic or asymptomatic DVT (bilateral ascending venography. Results Mean age was 71 ± 10 years with a higher prevalence of previous DVT (8vs.4% and pulmonary embolism (PE (4vs.1% in the high dose group. Mean duration of surgery was 82 ± 32 and 85 ± 36 min. DVT was detected in 28 (11.1% of the low dose and 35 (14.1% of the high dose group (p = n.s.. Combined distal-proximal DVT was observed in 5 (2% and 4 (1.6% patients respectively. No difference in bleeding events was found. Conclusion This trial confirms prior data showing that the conventional dosage of 3,000 IU aXa is effective and safe for the prevention of venous thromboembolic events after hip replacement surgery.

  19. Economía, bienes públicos puros e Internet : revelando el caso del FLOSS (“Free/Libre Open Source Software” o “Software Libre y Software de Código Abierto”)

    OpenAIRE

    Soler Muñoz, Rafael

    2013-01-01

    Desde que Paul Samuelson publicase en 1954 su obra “The pure theory of public expenditure”, diferenciando los bienes económicos entre bienes públicos y bienes privados, ha existido controversia sobre la posibilidad de que los bienes públicos pudiesen encontrarse en estado "puro". En nuestra tesis exponemos, con el ejemplo del FLOSS (Free/Libre Open Source Software), como la existencia de bienes públicos puros tendría lugar cuando bienes digitales son distribuidos a través de redes "peer to pe...

  20. Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity

    Science.gov (United States)

    Iyer, Janaki Krishnamurthy; Shih, Norrapat; Majumder, Munmi; Mattaparthi, Venkata Satish Kumar; Mukhopadhyay, Rupak; Doley, Robin

    2016-01-01

    In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques. The purified protein, named daboxin P accounts for ~24% of the total protein of the crude venom and has a molecular mass of 13.597 kDa. It exhibits strong anticoagulant and phospholipase A2 activity but is devoid of any cytotoxic effect on the tested normal or cancerous cell lines. Its primary structure was deduced by N-terminal sequencing and chemical cleavage using Edman degradation and tandem mass spectrometry. It is composed of 121 amino acids with 14 cysteine residues and catalytically active His48 -Asp49 pair. The secondary structure of daboxin P constitutes 42.73% of α-helix and 12.36% of β-sheet. It is found to be stable at acidic (pH 3.0) and neutral pH (pH 7.0) and has a Tm value of 71.59 ± 0.46°C. Daboxin P exhibits anticoagulant effect under in-vitro and in-vivo conditions. It does not inhibit the catalytic activity of the serine proteases but inhibits the activation of factor X to factor Xa by the tenase complexes both in the presence and absence of phospholipids. It also inhibits the tenase complexes when active site residue (His48) was alkylated suggesting its non-enzymatic mode of anticoagulant activity. Moreover, it also inhibits prothrombinase complex when pre-incubated with factor Xa prior to factor Va addition. Fluorescence emission spectroscopy and affinity chromatography suggest the probable interaction of daboxin P with factor X and factor Xa. Molecular docking analysis reveals the interaction of the Ca+2 binding loop; helix C; anticoagulant region and C-terminal region of daboxin P with the heavy chain of factor Xa. This is the first report of a phospholipase A2 enzyme from Indian viper venom which targets both factor X and factor Xa for its anticoagulant activity. PMID:27089306

  1. Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity.

    Directory of Open Access Journals (Sweden)

    Maitreyee Sharma

    Full Text Available In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques. The purified protein, named daboxin P accounts for ~24% of the total protein of the crude venom and has a molecular mass of 13.597 kDa. It exhibits strong anticoagulant and phospholipase A2 activity but is devoid of any cytotoxic effect on the tested normal or cancerous cell lines. Its primary structure was deduced by N-terminal sequencing and chemical cleavage using Edman degradation and tandem mass spectrometry. It is composed of 121 amino acids with 14 cysteine residues and catalytically active His48 -Asp49 pair. The secondary structure of daboxin P constitutes 42.73% of α-helix and 12.36% of β-sheet. It is found to be stable at acidic (pH 3.0 and neutral pH (pH 7.0 and has a Tm value of 71.59 ± 0.46°C. Daboxin P exhibits anticoagulant effect under in-vitro and in-vivo conditions. It does not inhibit the catalytic activity of the serine proteases but inhibits the activation of factor X to factor Xa by the tenase complexes both in the presence and absence of phospholipids. It also inhibits the tenase complexes when active site residue (His48 was alkylated suggesting its non-enzymatic mode of anticoagulant activity. Moreover, it also inhibits prothrombinase complex when pre-incubated with factor Xa prior to factor Va addition. Fluorescence emission spectroscopy and affinity chromatography suggest the probable interaction of daboxin P with factor X and factor Xa. Molecular docking analysis reveals the interaction of the Ca+2 binding loop; helix C; anticoagulant region and C-terminal region of daboxin P with the heavy chain of factor Xa. This is the first report of a phospholipase A2 enzyme from Indian viper venom which targets both factor X and factor Xa for its anticoagulant activity.

  2. Perspectivas sobre la gobernanza de los bienes y la ciudadanía en la obra de Elinor Ostrom

    OpenAIRE

    Leticia Merino Pérez

    2014-01-01

    Este trabajo reflexiona sobre las principales aportaciones conceptuales y me - todológicas de la obra de Elinor Ostrom, con - siderando el contexto conceptual y político en que emergió y se desarrolló: la polémica con las hegemónicas tesis de Garret Hardin sobre la tragedia de los bienes comunes y la teo - ría de la elección racional. Analiza las ruptu - ras y continuidades de la obra de Ostrom en relación con distintos paradigmas dominantes en las ciencias sociales. Indica también que sus ap...

  3. La place de l’évaluation des biens environnementaux dans la décision publique

    OpenAIRE

    Point, Patrick

    2007-01-01

    Dans les économies d’aujourd’hui, la plupart des biens et des services se voient dotés d’un prix. Ce prix agit comme un signal permettant d’orienter et de coordonner les comportements des consommateurs et des producteurs. Les ressources naturelles qui sont des dons de nature n’ont pas, pour nombre d’entre elles, un repère de prix qui leur soit attaché. Ceci crée une responsabilité spéciale pour les pouvoirs publics. Il est en effet nécessaire d’identifier les services rendus par les actifs na...

  4. Recensión La economía del bien común, de Christian Felber

    OpenAIRE

    Antonio Fernández Laborda

    2014-01-01

    El autor propone que el sistema económico persiga el mismo fin que el establecido en las normas políticas, es decir, el bien común. Felber parte de la premisa de que las empresas compiten entre ellas y, principalmente, se preocupan por aumentar sus beneficios en su cuenta de resultados. Por ello propone que esos resultados incorporen índices relacionados con valores como el respeto a los derechos humanos, a los derechos de los trabajadores, al medio ambiente y a los valores democráticos como ...

  5. La gestión de lo común y para el bien común desde las aulas

    OpenAIRE

    Ortiz García, Mercedes; Garay Montañez, Nilda; Gómez Calvo, Verónica; Hidalgo Moratal, Moisés; Carmen PASTOR SEMPERE; Romero-Tarín, Adela

    2014-01-01

    La enseñanza universitaria fruto de la investigación del profesorado, enriquecida con la participación del alumnado, debe servir para realizar una reflexión de cuánto acontece fuera y dentro de las Aulas, para que los alumnos crezcan como expertos profesionales pero también como ciudadanos comprometidos con el servicio al bien común desde el saber y la ética. De ahí que nuestra Red a través de sus distintas disciplinas (Derecho Constitucional, Derecho Administrativo, Ciencia política y de la ...

  6. El emprendimiento social como impulsor del cambio hacia la economía del bien común

    OpenAIRE

    Priede Bergamini, Tiziana; López-Cózar Navarro, Cristina; Platero Jaime, Manuel; Arco Juan, Francisco Javier del; Díaz Ridao, Pedro

    2015-01-01

    En el presente trabajo se realiza un análisis conjunto de la Economía del Bien Común (EBC) y el emprendimiento social, con el objetivo de poner de relieve la relación existente entre ambos. Para ello, se analizan las bases sobre las que se asientan estos conceptos, y se realiza una comparación que permite establecer su conexión, destacando la importancia de elementos clave en el orden económico y en el social, tales como la búsqueda de un crecimiento equilibrado y sostenible, una creciente pr...

  7. Las madres del bien morir del Hospital de las Cinco Llagas de Sevilla en el Antiguo Régimen

    OpenAIRE

    Rivasplata Varillas, Paula Ermila

    2014-01-01

    Después del Concilio de Trento, el morir y el purgatorio cobraron gran importancia en la vida de los católicos. En instituciones regidas por la Iglesia como el hospital de las Cinco Llagas de Sevilla surgieron otras personas que ayudaban a los curas a bien morir. Se trataba de la “madre agonizante” que se encargaba de ayudar a las moribundas a morir en paz que ejecutaba desde que el médico o cirujano ordenaba administrar el Santo Óleo de la extremaunción. Esta...

  8. [Surgery and invasive procedures in patients on long-term treatment with oral direct thrombin or factor Xa inhibitors].

    Science.gov (United States)

    Sié, P; Samama, C-M; Godier, A; Rosencher, N; Steib, A; Llau, J-V; van der Linden, P; Pernod, G; Lecompte, T; Gouin-Thibault, I; Albaladejo, P

    2011-09-01

    Direct oral anticoagulants (DOAs), inhibitors of factor IIa or Xa, are expected to replace vitamin K antagonists in most of their indications. It is likely that patients on long-term treatment with DOAs will be exposed to elective or emergency surgery or invasive procedures. Due to the present lack of experience in such conditions, we cannot make recommendations, but only propose perioperative management for optimal safety as regards the risk of bleeding and thrombosis. DOAs may increase surgical bleeding, they have no validated antagonists, they cannot be monitored by simple, standardised laboratory assays, and their pharmacokinetics vary significantly from patient to patient. Although DOAs differ in many respects, the proposals in the perioperative setting need not be specific to each. For procedures with low risk of haemorrhage, a therapeutic window of 48 h (last administration 24h before surgery, restart 24h after) is proposed. For procedures with medium or high haemorrhagic risk, we suggest stopping DOAs 5 days before surgery to ensure complete elimination of the drug in all patients. The treatment should be resumed only when the risk of bleeding has been controlled. In patients with a high risk of thrombosis (e.g. those in atrial fibrillation with an antecedent of stroke), bridging with heparin (low molecular weight, or unfractionated if the former is contraindicated) is proposed. In emergency, the procedure should be postponed for as long as possible (minimum 1-2 half-lives) and non-specific anti-haemorrhagic agents, such as recombinant human activated factor VIIa, or prothrombin concentrates, should not be given for prophylactic reversal, due to their uncertain benefit-risk. PMID:21820844

  9. CP1H-XA40CDR-A可编程器内置模拟量功能在制冷试验装置中应用%The Built-in Analog Functions of CP1H-XA40CDR-A Programmable Used in the Refrigeration Test Device

    Institute of Scientific and Technical Information of China (English)

    杨厚太; 郝颖磊

    2011-01-01

    主要介绍CP1H-XA40CDR-A可编程控制器的内置模拟量输入功能在制冷试验装置中的应用,着重介绍模拟量输入在恒温水箱上的应用,模拟输出在控制无级冷水机组上的应用以及编程时候需要注意的事项。%This article mainly introduces the CP1H-XA40CDR-A built-in analog input capability of programmable logic controller application in refrigeration test equipment,focuses on analog input application in thermostat water tank,analog output in controlled stepless chiller applications,and programming time on matters requiring attention.

  10. Manipulación mediática, identidad juvenil y prostitución de un bien necesario

    OpenAIRE

    Alexander Mosquera

    2007-01-01

    Algo que identifi ca al joven de hoy es la telefonía móvil, una nueva tecnología que invade todas las esferas de lavida pública y privada, cuya presencia se hace sentir a través de una multiplicidad de “ring-tones”. Este trabajo tienecomo objetivo general describir la interrelación que se da entre la manipulación de los medios a través del discursopublicitario sobre celulares, la construcción de la identidad juvenil y la prostitución de lo que otrora fuera un bien necesariocomo el teléfono. S...

  11. La Cultura Corporativa, esencial para el desarrollo de la Economía del Bien Común

    OpenAIRE

    Guerra Carlos, Luis Enrique

    2015-01-01

    La cultura corporativa adquiere actualmente una dimensión relevante como requisito indispensable para el progreso de la Economía del Bien Común: una corriente emergente que propone un nuevo modelo económico basado en la colaboración y una redistribución más equitativa de los recursos para la búsqueda del beneficio social. La integración de esta iniciativa requiere que las compañías sean capaces de adaptar esas ideas a través de su cultura; de su manera de pensar y actuar, y de la alineación e...

  12. Étude comparative de substances bioactives pour la protection des biens patrimoniaux contre les insectes ravageurs

    OpenAIRE

    Nicosia, Grazia; Fohrer, Fabien; Dechezleprêtre, Yoanna; Billerbeck, Virginia Gisel de

    2013-01-01

    Certaines collections patrimoniales sont infestées de manière cyclique par les insectes ravageurs. Les traitements curatifs utilisés sont des opérations ponctuelles d'éradication et ne règlent en aucune manière les ré-infestations chroniques des biens culturels sensibles. Certains produits répulsifs sont pour cela utilisés de manière préventive. Or la plupart s'avèrent dangereux pour l’homme et nombre d'entre eux sont en passe d’être interdits par la réglementation européenne et sa transcript...

  13. DISEÑO DE TARIFAS DE BIENES PÚBLICOS LOCALES. CONSIDERACIONES EN TORNO AL CASO DEL AGUA POTABLE

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Gómez Prado

    2013-10-01

    Full Text Available El recurso agua se constituye como un bien de primera necesidad, que no ha sido valorado de manera adecuada. Su valor no contempla los beneficios que genera en términos de bienestar, salud, económicos y ambientales, entre otros. No se explota de manera correcta, desperdiciándolo y contaminándolo indiscriminadamente.En últimas fechas se ha acentuado la discusión sobre la problemática de la disponibilidad del agua, y aunque en algunas regiones se presenta un escenario poco pesimista, es cierto que este recurso no se utiliza adecuadamente; es decir, el problema radica en su gestión y tarifación.El presente trabajo plantea una serie de propuestas metodológicas para asignar un valor tarifario económicamente eficiente al agua potable; se determinará el precio del recurso hídrico mediante la metodología de análisis de los costos reales de producción, intentando asignar un precio que permita solventar los costos medios de producción de largo plazo, así como utilidades que permitan reinversión ante incrementos futuros de la demanda sin afectar el precio.Valga señalar que la asignación de precios al recurso hídrico no se constituye en sí misma como una finalidad; se trata, más bien de la antesala del financiamiento del desarrollo local.

  14. Transport and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans at the Bien Hoa Agent Orange hotspot in Vietnam.

    Science.gov (United States)

    Van Thuong, Nguyen; Hung, Nguyen Xuan; Mo, Nguyen Thi; Thang, Nguyen Manh; Huy, Pham Quang; Van Binh, Hoang; Nam, Vu Duc; Van Thuy, Nguyen; Son, Le Ke; Minh, Nguyen Hung

    2015-10-01

    The Bien Hoa airbase (south of Vietnam) is known as one of the Agent Orange hotspots which have been seriously contaminated by Agent Orange/dioxin during the Vietnam War. Hundreds of samples including soil, sediment and fish were collected at the Bien Hoa Agent Orange hotspot for assessment of the environmental contamination caused by dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs). The toxicity equivalency quotient (TEQ) concentration of PCDD/Fs in soil and sediment varied from 7.6 to 962,000 and 17 to 4860 pg/g dry wt, respectively, implying very high contamination of PCDD/Fs in several areas. PCDD/F levels in fish ranged between 1.8 and 288 pg/g TEQ wet wt and was generally higher than advisory guidelines for food consumption. 2,3,7,8-Tetrachlorinated dibenzo-p-dioxins (2,3,7,8-TCDD) contributed 66-99 % of TEQ for most of the samples, suggesting 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) from Agent Orange as the major source of the contamination. The vertical transport of PCDD/Fs was observed in soil column with high TEQ levels above 1000 pg/g dry wt (Vietnamese limit for necessary remediation activities- TCVN 8183:2009 (2009)) even at a depth of 1.8 m. The vertical transport of PCDD/Fs has probably mainly taken place during the "Ranch Hand" defoliant spray activities due to the leaks and spills of phenoxy herbicides and solvents. The congener patterns suggest that transports of PCDD/Fs by weathering processes have led to their redistribution in the low-land areas. Also, an estimate for the total volume of contaminated soil requiring remediation to meet Vietnamese regulatory limits is provided. PMID:25510612

  15. La location de l'usage : une interprétation écoresponsable du service ? : cas des biens en partage

    OpenAIRE

    Carry, Dominique,

    2013-01-01

    Des offres de location de biens en partage fleurissent dans les villes : Vélib’, Autolib’, l’autopartage.... Louer l’usage suppose de partager l’utilisation du bien à plusieurs et d’accepter de se dégager de la matérialité au profit de la fonctionnalité. C’est aussi un argument en faveur d’une consommation plus écoresponsable. Louer l’usage d’un bien en partage ou l’acheter, qu’en pense le consommateur ? La valeur réside dans les bénéfices qu'il retire de l’utilisation, et non de la possessio...

  16. La protección de bienes urbanos. Avances en la política pública de Medellín

    OpenAIRE

    Clara In��s Atehortúa-Arredondo

    2010-01-01

    La problemática de la protección de bienes en el país es una pregunta obligatoria para quienes tienen dentro de su labor el reconocimiento, la restitución y la reparación de las víctimas del desplazamiento forzado. Uno de los puntos que deben analizarse dentro de esta problemática es lo concerniente a la protección de bienes urbanos y cuya responsabilidad está en cabeza de los municipios. El desarrollo de una política pública por parte de la ciudad de Medellín para la protección de bienes es ...

  17. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)

    DEFF Research Database (Denmark)

    Halperin, Jonathan L; Hankey, Graeme J; Wojdyla, Daniel M;

    2014-01-01

    BACKGROUND: Nonvalvular atrial fibrillation is common in elderly patients, who face an elevated risk of stroke but difficulty sustaining warfarin treatment. The oral factor Xa inhibitor rivaroxaban was noninferior to warfarin in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compar...

  18. La Obra Bien Hecha para la mejora docente: un enfoque práctico en el Módulo Repoblaciones Forestales y Tratamientos Selvícolas

    OpenAIRE

    Ramírez-Valiente, María

    2015-01-01

    La ejecución de las diferentes actividades y prácticas que se realizan en los Ciclos Formativos han de contribuir a la cualificación profesional del alumnado que los cursa. Se entiende que sería mucho más efectiva desde la Obra Bien Hecha y la personalización educativa de dichos Ciclos. A partir de lo cual, el objetivo general del TFM es abordar de forma teórica-práctica la Obra Bien Hecha en el Módulo de Repoblaciones Forestales y Tratamientos Selvícolas (RFTS ) del Ciclo Formativo de Grado ...

  19. Administración económica del distrito inquisitorial de Valencia: la receptoría de bienes confiscados (1482-1493)

    OpenAIRE

    Tomás Botella, Bernardo

    2016-01-01

    El objeto de esta tesis doctoral es la receptoría de bienes confiscados de la Inquisición de Valencia, su estructura burocrática y sus procedimientos de actuación sobre la sociedad valenciana bajomedieval. Esta oficina se encargaba de ejecutar el secuestro y confiscación del patrimonio de los herejes condenados, así como de gestionar y liquidar dichos bienes una vez incorporados al fisco regio. Además, se ha analizado la evolución institucional que experimentó el Santo Oficio durante el perio...

  20. Gasto particularista en bienes públicos locales: índice de desviación Particularistic expenditure on local public goods: an index of deviation

    OpenAIRE

    María Alejandra Armesto

    2012-01-01

    El gasto particularista del gobierno se opone al gasto programático. Los dos tipos de medidas clasifican los beneficios de políticas como particularistas si son bienes exclusivos o si son explicados por variables políticas. Este artículo desarrolla un índice de gasto particularista en bienes públicos locales medido como desviación con respecto al programa. Se aplica el índice a la oferta de servicios básicos por administraciones subnacionales seleccionadas en México y Argentina. Se muestra qu...

  1. Una aproximación a los factores claves para la gestión de los bienes de patrimonio cultural

    OpenAIRE

    Fresneda Fuentes, Silvia; Lobo Gallardo, Antonio

    2014-01-01

    El turismo cultural está basado en la gestión y explotación, entre otros, de los bienes catalogados como patrimonio cultural. La necesidad de obtener resultados positivos ha generado una preocupación creciente por identificar los factores clave de éxito. El principal objetivo de este trabajo ha sido la identificación de los mismos, para lo que se ha realizado una revisión bibliográfica. Entendemos que la gestión de estos bienes se debe abordar de la lógica de la mejora continua y una perspect...

  2. Competitividad de la industria de bienes de equipo de España y Alemania (1993-2008): ventaja absoluta y costes relativos

    OpenAIRE

    Boundi Chraki, Fahd

    2014-01-01

    El presente trabajo realizará un análisis comparativo del sector de bienes de equipo de España y Alemania, con el objeto de desentrañar los determinantes de la competitividad de esta industria. La hipótesis central es la siguiente: la industria de bienes de equipo de Alemania es más competitiva debido a su mayor productividad real y sus menores costes relativos. De este modo, se partirá de la teoría clásica y marxiana de la formación de los precios, y el modelo de las ventajas absolutas de An...

  3. Determinación de los precios implícitos en bienes inmuebles : una alternativa a la modelización hedónica

    OpenAIRE

    Ceular Villamandos, Nuria; Caridad y Ocerin, José María

    2004-01-01

    RESUMEN Recientemente un nuevo enfoque para estimar el valor de bienes inmuebles está siendo cada vez más usado. Para ello se usan atributos internos del bien, y externos, del entorno, pues ambos son percibidos de forma diferente en el mercado. Así pues, propiedades con nivel de precios similar son consideradas como claramente diferenciadas en los mercados inmobiliarios. Las técnicas de Inteligencia Arti cial proporcionan nuevas posibilidades, en comparación con la modelización econométrica ...

  4. Los bienes habices y la repoblación de Andalucía en el siglo XIII : el caso de Sevilla

    OpenAIRE

    García Sanjuán, Alejandro

    1999-01-01

    Los legados piadosos o bienes habices constituyen una de las instituciones socioeconómicas islámicas más relevantes durante la Edad Media. Dichos bienes, jurídicamente inalienables, proceden de donaciones voluntarias realizadas por los creyentes musulmanes para cualquier finalidad considerada piadosa desde un punto de vista islámico, de manera particular a favor de pobres y enfermos, para el rescate de prisioneros, para contribuir al sostenimiento de las fronteras y al esfuerzo por defender ...

  5. Identification of microsatellite markers (SSR linked to a new bacterial blight resistance gene xa33(t in rice cultivar ‘Ba7’

    Directory of Open Access Journals (Sweden)

    Theerayut Toojinda

    2009-05-01

    Full Text Available This study attempts to identify a new source of bacterial blight (BB resistance gene and microsatellite makers (SSR linked to it. A total number of 139 F2 progenies generated from a cross between the resistant donor ‘Ba7’and ‘Pin Kaset’ were developed and used for this study. A Thai Xoo isolate, TXO16, collected from Phitsanulok province, was used to evaluate the resistance reaction in the F2 population. The segregation ratio of resistance (R and susceptibility (S was statistically fitted to 1R:3S model indicating single recessive gene segregation. Twenty F2 individuals consisting of 10 resistant and 10 susceptible plants were chosen for DNA analysis. Sixty-two polymorphic markers covering all rice chromosomes were used to identify the location and linked markers of the resistance gene. Four SSR markers, viz. RM30, RM7243, RM5509 and RM400, located on the long arm of rice chromosome 6, could clearly discriminate between resistant and susceptible phenotypes, and 161 BC2F2:3 individuals carrying BB resistance gene were developed through MAS using these SSR markers. This population was inoculated with TXO16 to validate and confirm the location of the gene and linked markers. The segregation ratio was statistically fitted to 1R:3S model confirming a recessive nature of the gene action in this germplasm. Phenotypic-genotypic association including five additional markers suggested that RM20590 was tightly linked to this resistance gene (R2=59.12 %. The BB phenotype was controlled by a recessive gene with incomplete dominance of susceptible allele providing intermediate resistance to Xoo pathogen in heterozygotes. The location of the gene was in the vicinity of a dominant gene, Xa7, which was previously reported. However, the resistance gene identified here was different from Xa7 because of the different nature of gene action. Consequently, this gene was tentatively designated as xa33(t. The resistance gene from rice cultivar ‘Ba7’ and the

  6. El castellano bien templado

    OpenAIRE

    Sáenz, Miguel

    2009-01-01

    Este artículo se sirve de la música para establecer un paralelismo entre ésta y la traducción, pues si la traducción es una interpretación (musical) de un texto, puede haber innumerables traducciones válidas, pudiendo haber alguna “de referencia”. Además, se plantea que las facultades son como conservatorios donde los futuros traductores estudian técnicas y aprenden fundamentos teóricos (que compara con el solfeo, la armonía y la composición) y que las traducciones “envejecen” porque su es...

  7. Créations graphiques réussissez vos brochures, logos, pages web, newsletters, flyers, et bien plus encore !

    CERN Document Server

    McWade, John

    2010-01-01

    Dans cet ouvrage, qui regroupe un florilège des meilleurs projets professionnels publiés dans son célèbre magazine de graphisme, Before & After, John McWade offre une présentation approfondie des principes de base du graphisme, avant de partager concrètement techniques et procédés. Dans un style simple et convivial, il analyse différentes créations graphiques abouties – brochures, lettres d'information, sites web, cartes de visite et autres supports visuels – et explique le pourquoi et le comment de leur réussite. À votre tour, inspirez-vous de ces exemples et employez ces mêmes techniques à l'envie pour améliorer vos propres documents. Vous apprendrez à: rogner des photos pour parfaire leur fonction et leur signification; attirer le regard du lecteur à l'emplacement souhaité à l'aide de huit solutions différentes; travailler sur les composants de base de la création graphique, tels que le trait, la forme, la direction, le mouvement, la mise à l'échelle, la couleur, et bien d'a...

  8. El consumo de bienes religiosos. Una introducción económica al caso español

    Directory of Open Access Journals (Sweden)

    Brañas-Garza, Pablo

    2003-08-01

    Full Text Available This paper uses the Economic of Religion issues to explore Spanish religious behaviour. Under this microeconomic framework religious practise is considered "rational" using Azzi-Ehrenberg (1975 arguments: salvation, social and professional motives. We test if that hypotheses may explain Spanish religious activity. To this end we run descriptive and multivariate analysis that allows us to conclude the following: theoretical models well perform Spanish data; gender, ageing, family size and education are positive determinant of church-attendance; the influence of parents behaviour on children religious activity.

    Este trabajo explora el comportamiento religioso de los españoles desde el enfoque de la Economía de la Religión. En un marco microeconómico y utilizando los argumentos de Azzi- Ehrenberg (1975 —motivo salvación, consumo y profesional—, la práctica religiosa resulta racional. En esta investigación estudiamos si estas hipótesis pueden explicar el comportamiento religioso de los españoles. Para ello se realizan análisis descriptivos y multivariantes que nos permiten concluir que: los modelos teóricos explican bien los datos españoles; que el sexo, la edad, el tamaño de la familia y la educación son determinantes positivos de la asistencia a iglesia; que el ejemplo de los padres influye en la actividad religiosa actual de los hijos.

  9. Prevention of venous thromboembolism with an oral factor Xa inhibitor, YM150, after total hip arthroplasty. A dose finding study (ONYX-2)

    DEFF Research Database (Denmark)

    Eriksson, B I; Turpie, A G G; Lassen, M R; Prins, M H; Agnelli, G; Kälebo, P; Wetherill, G; Wilpshaar, J W; Meems, L

    2010-01-01

    BACKGROUND: Anticoagulant prophylaxis substantially reduces the risk of venous thromboembolism (VTE) after major orthopedic surgery. The direct factor Xa inhibitor YM150 is currently under investigation for the prevention of VTE, stroke and ischemic vascular events in patients after orthopedic...... surgery, with atrial fibrillation and with acute coronary syndrome, respectively. OBJECTIVES: To investigate the efficacy and safety of YM150 for the prevention of VTE following elective total hip arthroplasty. PATIENTS/METHODS: Patients were randomized to postoperative, once-daily, oral YM150 (5, 10, 30......, 60 or 120 mg) (double-blind) or preoperative subcutaneous (open label) enoxaparin (40 mg) for 5 weeks. The primary efficacy endpoint comprised VTE diagnosed by mandatory bilateral venography or verified symptomatic deep vein thrombosis (DVT) plus all deaths up to 9 days after surgery. The primary...

  10. Contribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase†,‡

    Science.gov (United States)

    2010-01-01

    Factor Va, the cofactor of prothrombinase, is composed of heavy and light chains associated noncovalently in the presence of divalent metal ions. The COOH-terminal region of the heavy chain contains acidic amino acid clusters that are important for cofactor activity. In this work, we have investigated the role of amino acid region 659−663, which contains five consecutive acidic amino acid residues, by site-directed mutagenesis. We have generated factor V molecules in which all residues were mutated to either lysine (factor V5K) or alanine (factor V5A). We have also constructed a mutant molecule with this region deleted (factor VΔ659−663). The recombinant molecules along with wild-type factor V (factor VWT) were transiently expressed in mammalian cells, purified, and assessed for cofactor activity. Two-stage clotting assays revealed that the mutant molecules had reduced clotting activities compared to that of factor VaWT. Kinetic analyses of prothrombinase assembled with the mutant molecules demonstrated diminished kcat values, while the affinity of all mutant molecules for factor Xa was similar to that for factor VaWT. Gel electrophoresis analyses of plasma-derived and recombinant mutant prothrombin activation demonstrated delayed cleavage of prothrombin at both Arg320 and Arg271 by prothrombinase assembled with the mutant molecules, resulting in meizothrombin lingering throughout the activation process. These results were confirmed after analysis of the cleavage of FPR-meizothrombin. Our findings provide new insights into the structural contribution of the acidic COOH-terminal region of factor Va heavy chain to factor Xa activity within prothrombinase and demonstrate that amino acid region 659−663 from the heavy chain of the cofactor contributes to the regulation of the rate of cleavage of prothrombin by prothrombinase. PMID:20722419

  11. Manipulación mediática, identidad juvenil y prostitución de un bien necesario

    Directory of Open Access Journals (Sweden)

    Alexander Mosquera

    2007-01-01

    Full Text Available Algo que identifi ca al joven de hoy es la telefonía móvil, una nueva tecnología que invade todas las esferas de lavida pública y privada, cuya presencia se hace sentir a través de una multiplicidad de “ring-tones”. Este trabajo tienecomo objetivo general describir la interrelación que se da entre la manipulación de los medios a través del discursopublicitario sobre celulares, la construcción de la identidad juvenil y la prostitución de lo que otrora fuera un bien necesariocomo el teléfono. Se abordó un corpus compuesto por varios avisos publicitarios que circularon en los diariosvenezolanos El Nacional, La Verdad y Panorama durante agosto de 2005, desde la perspectiva teórico-metodológicade la semiótica crítica de González de Ávila y de la semiótica de la cultura de Lotman. También se utilizaron algunosaportes de Magariños de Morentin relacionados con la semiótica de los mensajes publicitarios, así como los de Caro Almela, Bourdieu, Pasquali y Eco sobre los mass-media. Los resultados revelaron una manipulación mediática a través del discurso publicitario, dirigida a crear la urgente necesidad de poseer un celular, porque éste es el signo-mercancía con el cual se identifi ca el joven actual. Una conclusión preliminar indica que la no-posesión de ese aparato hace aparecer al joven como un “excluido” de ese mundo de la telefonía móvil.

  12. La economía social y solidaria como alternativa económica. Bienes comunes y democracia

    Directory of Open Access Journals (Sweden)

    Jaime Abad Montesinos

    2014-10-01

    Full Text Available Normal 0 21 MicrosoftInternetExplorer4 Resumen: El presente artículo trata de enmarcar la economía social y solidaria en el seno del actual debate producto de la crisis económica vigente, haciendo especial hincapié en las cuestiones relacionadas con los bienes comunes y la gestión democrática. La crisis presente ha puesto de manifiesto la necesidad de proponer modelos socio-económicos alternativos que aúnen democracia, compromiso social y sostenibilidad del medio ambiente. La economía social y solidaria, sin ser un programa homogéneo, está contribuyendo a proponer respuestas a algunos de los problemas actuales en materia de desempleo e integración social, revalorizando en los procesos económicos, no sólo los intercambios mercantiles, sino también los intereses sociales y los recursos naturales. Abstract:This article aims to enlighten the importance ofsolidary and social economy in the present discussion, whose importance has increased as a result of the current economic crisis, making a special emphasis on subjects such as commons goods and democratic management. The crisis has brought up the need for alternative socio-economical management models which must combine democracy, social commitment and environmental sustainability. Solidary and social economy, without being a homogeneous program, are proposing answers to some of the present problems related to unemployment and social integration, contributing to increase the value of economic processes, not only in commercial exchanges, but also the social interest and natural resources. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} /* Style Definitions */ table.MsoNormalTable {mso

  13. Prolegómenos al vivir bien-buen vivir: una evaluación normativa y práctica

    Directory of Open Access Journals (Sweden)

    Edwin Cruz Rodríguez

    2015-06-01

    Full Text Available Este trabajo examina el concepto de vivir bien-buen vivir ponderando sus contribuciones y limitaciones. Esta cosmovisión tiene un horizonte normativo más ambicioso que el paradigma del desarrollo, pues apuesta por una concepción de la pobreza y la riqueza que no se reduce a la acumulación de bienes materiales, una economía que comprende sus efectos sobre la naturaleza y se centra en la satisfacción de necesidades, y una descolonización de los saberes. No obstante, se caracteriza por un déficit de operacionalización que se manifiesta en la dificultad para definir políticas concretas e indicadores de medición precisos.

  14. “Jeneros de gusto y sobretodos ingleses”: el impacto cultural del consumo de bienes ingleses por la clase alta bogotana .

    Directory of Open Access Journals (Sweden)

    Ana Maria Otero Cleves.

    2009-05-01

    Full Text Available Este artículo analiza el impacto cultural del consumo de bienes Inglés por la clase alta de Bogotá durante el siglo XIX. Se sugiere que el consumo de productos Inglés después de la independencia del país fue uno de los principales mecanismos empleados por las clases altas para asegurar su posición social, así como para construir una nación moderna, de acuerdo a las normas europeas. Por lo tanto, el artículo analiza el papel que el consumo de bienes extranjeros en el proceso de construcción de la nación y la diferenciación social en el siglo XIX.

  15. Ethique de la population : l'apport des critères de bien-être dépendant du rang

    OpenAIRE

    Zuber, Stéphane

    2016-01-01

    Cet article présente l'intérêt que peuvent avoir des critères de bien-être dépendant du rang dans le cadre de l'éthique de la population. Ce champ de recherche s'intéresse à l'évaluation et à la comparaison d'allocations lorsque des populations de tailles différentes sont en jeu. On montre que les critères de bien-être dépendant du rang ne sont pas sujets à plusieurs écueils auxquels sont confrontés les critères utilitaristes (généralisés) habituellement étudiés dans ce champ....

  16. Fuentes de información para el diseño de un Sistema de Vigilancia e Inteligencia en el Registro Provincial de Bienes Culturales de Matanzas

    Directory of Open Access Journals (Sweden)

    Justa Bielka Cantillo González

    2007-01-01

    Full Text Available Por la importancia que reviste la conservación del Patrimonio Cultural, se identifican, con la utilización de herramientas estadísticas (Coeficiente de Concordancia de Kendall las fuentes de información relevantes, para el posterior diseño de un Sistema de Vigilancia e Inteligencia en el Registro Provincial de Bienes Culturales de la provincia de Matanzas

  17. Fuentes de información para el diseño de un sistema de vigilancia e inteligencia en el registro provincial de bienes culturales de Matanzas.

    Directory of Open Access Journals (Sweden)

    Lilian Delia Curiel Lorenzo

    2010-10-01

    Full Text Available Por la importancia que reviste la conservación del Patrimonio Cultural, se identifican, con la utilización de herramientas estadísticas (Coeficiente de Concordancia de Kendall las fuentes de información relevantes, para el posterior diseño de un Sistema de Vigilancia e Inteligencia en el Registro Provincial de Bienes Culturales de la provincia de Matanzas.

  18. El dominio público y los bienes públicos: Europa y América Latina. ¿El hijo sigue mirando al padre?

    Directory of Open Access Journals (Sweden)

    Sergio Chemás

    2015-12-01

    Full Text Available El estudio del derecho de los bienes públicos en América Latina y en Colombia es algo todavía poco desarrollado. Se sigue mirando hacia el derecho comparado para obtener respuestas, tal como un hijo mira a su padre, porque fue allá donde surgieron los grandes desarrollos del tema. El dominio público en Europa y América Latina es producto de un encuentro entre varias autoridades en el tema de los bienes públicos tanto de Europa como de América Latina. Esta reseña se divide en tres partes: i un breve análisis de derecho comparado frente al concepto de dominio público; ii la identificación de los contenidos más interesantes e innovadores de los regímenes de bienes públicos, y iii un ejercicio académico para que el lector lo desarrolle al leer el libro.

  19. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor.

    Science.gov (United States)

    Kohrt, Jeffrey T; Bigge, Christopher F; Bryant, John W; Casimiro-Garcia, Agustin; Chi, Liguo; Cody, Wayne L; Dahring, Tawny; Dudley, Danette A; Filipski, Kevin J; Haarer, Staci; Heemstra, Ron; Janiczek, Nancy; Narasimhan, Lakshmi; McClanahan, Thomas; Peterson, J Thomas; Sahasrabudhe, Vaisheli; Schaum, Robert; Van Huis, Chad A; Welch, Kathleen M; Zhang, Erli; Leadley, Robert J; Edmunds, Jeremy J

    2007-08-01

    Herein, we report the discovery of novel, proline-based factor Xa inhibitors containing a neutral P1 chlorophenyl pharmacophore. Through the additional incorporation of 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one 22, as a P4 pharmacophore, we discovered compound 7 (PD 0348292). This compound is a selective, orally bioavailable, efficacious FXa inhibitor that is currently in phase II clinical trials for the treatment and prevention of thrombotic disorders. PMID:17683371

  20. The pharmacokinetics of darexaban (YM150), an oral direct factor Xa inhibitor, are not affected by ketoconazole, a strong inhibitor of CYP3A and P-glycoprotein.

    Science.gov (United States)

    Groenendaal, Dorien; Strabach, Gregory; Garcia-Hernandez, Alberto; Kadokura, Takeshi; Heeringa, Marten; Mol, Roelof; Eltink, Charlotte; Onkels, Hartmut

    2014-05-01

    We investigated the effects of ketoconazole on the pharmacokinetics (PK) of the direct clotting factor Xa inhibitor darexaban (YM150) and its main active metabolite darexaban glucuronide (YM-222714) which almost entirely determines the antithrombotic effect. In this open-label, randomized, two-period crossover study, 26 healthy male volunteers received in one treatment period a single dose of darexaban 60 mg, and in the other treatment period, ketoconazole 400 mg once daily on Days 1-9 with a single dose of darexaban 60 mg on Day 4. Washout between periods was at least 1 week. The geometric mean ratio (90% confidence interval) of darexaban glucuronide (darexaban plus ketoconazole versus darexaban) for AUCinf was 1.11 (1.00, 1.23), and for Cmax 1.18 (1.03, 1.35). Darexaban concentrations remained very low (AUClast ∼196-fold lower) in relation to darexaban glucuronide concentrations. In conclusion, the PK of darexaban glucuronide was not affected to a clinically relevant degree by co-administration of the strong CYP3A/P-glycoprotein inhibitor, ketoconazole. The PK of the parent compound darexaban were changed, however, concentrations remained quantitatively insignificant in relation to the main active moiety, darexaban glucuronide. PMID:27128609

  1. Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban – an oral, direct Factor Xa inhibitor

    Directory of Open Access Journals (Sweden)

    Rolf eBurghaus

    2014-11-01

    Full Text Available The long-lasting anticoagulant effect of vitamin K antagonists can be problematic in cases of adverse drug reactions or when patients are switched to another anticoagulant therapy. The objective of this study was to examine in silico the anticoagulant effect of rivaroxaban, an oral, direct Factor Xa inhibitor, combined with the residual effect of discontinued warfarin. Our simulations were based on the recommended anticoagulant dosing regimen for stroke prevention in patients with atrial fibrillation. The effects of the combination of discontinued warfarin plus rivaroxaban were simulated using an extended version of a previously validated blood coagulation computer model. A strong synergistic effect of the two distinct mechanisms of action was observed in the first 2–3 days after warfarin discontinuation; thereafter, the effect was close to additive. Nomograms for the introduction of rivaroxaban therapy after warfarin discontinuation were derived for Caucasian and Japanese patients using safety and efficacy criteria described previously, together with the coagulation model. The findings of our study provide a mechanistic pharmacologic rationale for dosing schedules during the therapy switch from warfarin to rivaroxaban and support the switching strategies as outlined in the Summary of Product Characteristics and Prescribing Information for rivaroxaban.

  2. Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa.

    Science.gov (United States)

    Parasrampuria, Dolly A; Truitt, Kenneth E

    2016-06-01

    Edoxaban, a once daily non-vitamin K antagonist oral anticoagulant, is a direct, selective, reversible inhibitor of factor Xa (FXa). In healthy subjects, single oral doses of edoxaban result in peak plasma concentrations within 1.0-2.0 h of administration, followed by a biphasic decline. Exposure is approximately dose proportional for once daily doses of 15-150 mg. Edoxaban is predominantly absorbed from the upper gastrointestinal tract, and oral bioavailability is approximately 62 %. Food does not affect total exposure to edoxaban. The terminal elimination half-life in healthy subjects ranges from 10 to 14 h, with minimal accumulation upon repeat once daily dosing up to doses of 120 mg. The steady-state volume of distribution is approximately 107 L, and total clearance is approximately 22 L/h; renal clearance accounts for approximately 50 % of total clearance, while metabolism and biliary secretion account for the remaining 50 %. Intrinsic factors, such as age, sex and race, do not affect edoxaban pharmacokinetics after renal function is taken into account. Oral administration of edoxaban results in rapid changes in anticoagulatory biomarkers, with peak effects on anticoagulation markers (such as anti-FXa), the prothrombin time and the activated partial thromboplastin time occurring within 1-2 h of dosing. PMID:26620048

  3. Peculiaridades da terapia trombolítica na síndrome nefrótica pediátrica: monitorização do fator anti-Xa Particularities of thrombolytic therapy in pediatric nephrotic syndrome: anti-factor Xa monitoring

    Directory of Open Access Journals (Sweden)

    Patrícia Zambi Meirelles

    2008-06-01

    Full Text Available OBJETIVO: Descrever a importância do tromboembolismo pulmonar (TEP na síndrome nefrótica pediátrica e o uso da heparina de baixo peso molecular como opção terapêutica segura e eficaz. DESCRIÇÃO DO CASO: Menino de 5,7 anos com síndrome nefrótica córtico-resistente e glomérulo-esclerose segmentar e focal foi internado devido à diarréia, distúrbios eletrolíticos e anasarca. No 11º dia de internação, evoluiu com desconforto respiratório súbito, cuja investigação mostrou área de alta probabilidade de TEP na cintilografia pulmonar ventilação/perfusão e obstrução em veia jugular interna esquerda ao ultra-som doppler. Iniciado suporte ventilatório com nebulização de oxigênio e anticoagulação com enoxaparina (2mg/kg/dia. Após seis dias, evoluiu com sintomas neurológicos compatíveis com episódio isquêmico transitório, sem alteração na tomografia computadorizada de crânio. A monitorização do fator anti-Xa no soro demonstrou nível subterapêutico e a dose de enoxaparina foi ajustada para 3mg/kg/dia. O edema e os sintomas pulmonares melhoraram e o paciente recebeu alta hospitalar após 33 dias. COMENTÁRIOS: Embora o TEP seja raro em crianças, a síndrome nefrótica é uma condição pró-trombótica que favorece a complicação. A heparina de baixo peso molecular pode ser considerada no tratamento e na profilaxia secundária do TEP, sendo importante monitorizar o nível sérico do fator anti-Xa para ajustar sua dose e promover tratamento seguro e eficaz.OBJECTIVE: Report the importance of pulmonary thromboembolism (PTE in pediatric nephrotic syndrome and the use of low molecular weight heparin (LMWH as an effective and secure therapeutic option. CASE DESCRIPTION: A 5.7 year-old boy with steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis was admitted to the pediatric unit with diarrhea, electrolyte disturbances and anasarca. On the 11th day of hospital stay, he developed a sudden

  4. Estrategias de cumplimentación de pedidos en el sector de fabricación de bienes de equipo. Un estudio empírico

    OpenAIRE

    Sanchis Gisbert, Raquel; Saiz, Eduardo; Castellano, Eduardo; Poler Escoto, Raúl

    2011-01-01

    [ES] : El sector de bienes de equipo se caracteriza por fabricar productos complejos y con un alto grado de personalización. La elección de la estrategia de cumplimentación de pedidos que permita satisfacer de forma eficiente las necesidades específicas de sus clientes se convierte en una decisión estratégica de gran importancia. Como respuesta a esta demanda, el presente estudio analiza la relación entre diferentes estrategias de cumplimentación de pedidos (Ingeniería Bajo Pedido, Fabr...

  5. La Importancia del Grado de Intensidad de la Distribución en la Determinación del Valor de Marca de un Bien Duradero

    OpenAIRE

    Villarejo Ramos, Ángel Francisco

    2003-01-01

    En el presente trabajo pretendemos establecer una base teórica y empírica para la consideración de la influencia que ejerce el grado de intensidad con que es distribuido un bien duradero en la determinación del valor de marca de los mismos. Tras la revisión teórica que sustenta la posibilidad de aplicar técnicas de análisis basadas en los modelos de ecuaciones estructurales planteamos la confirmación empírica, en su caso, de las relaciones existentes entre la intensidad de la d...

  6. La doctrina de los bienes comunes de Francisco de Vitoria como fundamentación del dominio en el Nuevo Mundo

    OpenAIRE

    Añaños-Meza, M.C. (Mª Cecilia)

    2013-01-01

    En los últimos años se ha producido un renacimiento de la antigua idea de los bienes comunes como opción alternativa a las formas actuales de propiedad privada y pública, cuyos propulsores hacen referencia a su fuente más cierta, el derecho romano. Aunque es poco o nada conocido, esta idea fue empleada en el siglo XVI por el dominico español Francisco de Vitoria como una parte fundamental de su teoría del dominio que no sólo le va a servir para elaborar su análisis sob...

  7. AVANCES Y PERSPECTIVAS DEL DERECHO PARA LA RESTITUCIÓN DE BIENES CULTURALES A SUS PAÍSES DE ORIGEN EL CASO DEL PATRIMONIO CULTURAL

    OpenAIRE

    Antonio José Rengifo Lozano

    2008-01-01

    El debate sobre la restitución de bienes del patrimonio cultural, como una forma de reivindicación por coparte de los países de origen, se ha ido incrementando en la escena internacional y en el derecho publico, a favor de los procesos de constitucionalizacion de la cultura en el mundo, como ha sido el caso de la constitución política de Colombia de 1.991 de la adopción de tratados internacionales y del rol eficaz del comité intergubernamental de la UNESCO, como organismo internacional instit...

  8. Avances y perspectivas del derecho para la restitución de bienes culturales a sus países de origen: el caso del patrimonio cultural quimbaya

    OpenAIRE

    Rengifo Lozano, Antonio José

    2013-01-01

    Con base en el estudio comparado de los casos de restitución de los Mármoles del Partenón, promovido por Grecia y del Patrimonio Cultural Quimbaya en Colombia, el presente artículo sustenta la tesis de que aunque el derecho para la restitución de bienes culturales se encuentra en etapa inicial de consolidación y, por tanto, de seguro tendrá muchos desarrollos en el futuro, existen en la actualidad bases jurídicas suficientes para hacer efectiva esa restitución, necesaria para realizar el l...

  9. Perspectivas del crecimiento urbano: la actividad comercial minorista y el transporte de bienes en la Zona Metropolitana de Querétaro (México)

    OpenAIRE

    Eduardo Betanzo-Quezada

    2015-01-01

    Se muestran las perspectivas del crecimiento urbano, la actividad comercial minorista y su relación transversal con el transporte de bienes en la Zona Metropolitana de Querétaro (México). Con una metodología de análisis de información estadística de tipo agregado, se examinan esos determinantes con el objetivo de revelar sus tendencias en la ciudad. El paralelismo encontrado en las tendencias de comportamiento de los determinantes examinados conduce a concluir que es cada vez más necesario co...

  10. Economía del bien común y los DESC en la enseñanza del derecho constitucional

    OpenAIRE

    Garay Montañez, Nilda

    2013-01-01

    El presente es un trabajo que resulta de la aplicación de los principios básicos de la Economía del Bien Común en las clases de derecho constitucional. Principios que tienen estrecha relación con los denominados DESC: Derechos Económicos Sociales y Culturales que han venido desarrollándose en las sociedades donde el nivel de la pobreza es alto, es decir, los Estados de la región denominada de la periferia. Los Estados constitucionales occidentales han construido amplia doctrina al respecto, p...

  11. Los bienes de capital en el Programa de Cooperación e Integración Argentina-Brasil : 1986-1989

    OpenAIRE

    Luchetti, Javier Fernando

    2005-01-01

    El MERCOSUR es constituido como una continuidad del Programa de Integración y Cooperación entre Argentina y Brasil, si bien abandona sus principios fundamentales, cambiando sensiblemente su diseño global y el modelo de integración subyacente. El PICAB se proponía crear un espacio económico común para mejorar el bienestar de los pueblos, mediante una complementación de sectores de las economías de ambos países, según los principios de gradualismo, flexibilidad, selectividad, equilibrio, profun...

  12. La respuesta a la vocación al bien común de las empresas cotizadas en la bolsa mexicana de valores

    OpenAIRE

    Reyes-Sahagun, C. A. (Carlos Antonio); Dembinski, P. (Paul)

    2016-01-01

    Las decisiones en la empresa moderna tienen influencia de ideas académicas que ponen énfasis en la máxima eficiencia para generar beneficios económicos en favor del accionista y en los acuerdos contractuales entre las diversas partes interesadas. En esta tesis se investiga cómo estos dos aspectos pueden enriquecerse con el estudio del concepto de bien común de la tradición aristotélico-tomista y de la Doctrina Social de la Iglesia. Estas ideas proporcionan una visión más amplia...

  13. Reestimación del grado de transmisión de la tasa de cambio del peso sobre la inflación de los bienes importados

    OpenAIRE

    2014-01-01

    Conocer el grado de transmisión de los cambios en la tasa de cambio sobre la inflación interna es un interrogante constante de las autoridades monetarias de cualquier país. En este documento se reestima el grado de transmisión de corto y mediano plazo de las variaciones de la tasa de cambio del peso colombiano sobre la inflación de los bienes importados, estimados en González et al. (2010). Se utilizan datos trimestrales de Colombia para el período 1985-2014 y un modelo VAR no lineal de trans...

  14. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial.

    Science.gov (United States)

    Barco, Stefano; Lankeit, Mareike; Binder, Harald; Schellong, Sebastian; Christ, Michael; Beyer-Westendorf, Jan; Duerschmied, Daniel; Bauersachs, Rupert; Empen, Klaus; Held, Matthias; Schwaiblmair, Martin; Fonseca, Cândida; Jiménez, David; Becattini, Cecilia; Quitzau, Kurt; Konstantinides, Stavros

    2016-07-01

    Pulmonary embolism (PE) is a potentially life-threatening acute cardiovascular syndrome. However, more than 95 % of patients are haemodynamically stable at presentation, and among them are patients at truly low risk who may qualify for immediate or early discharge. The Home Treatment of Pulmonary Embolism (HoT-PE) study is a prospective international multicentre single-arm phase 4 management (cohort) trial aiming to determine whether home treatment of acute low-risk PE with the oral factor Xa inhibitor rivaroxaban is feasible, effective, and safe. Patients with confirmed PE, who have no right ventricular dysfunction or free floating thrombi in the right atrium or ventricle, are eligible if they meet none of the exclusion criteria indicating haemodynamic instability, serious comorbidity or any condition mandating hospitalisation, or a familial/social environment unable to support home treatment. The first dose of rivaroxaban is given in hospital, and patients are discharged within 48 hours of presentation. Rivaroxaban is taken for at least three months. The primary outcome is symptomatic recurrent venous thromboembolism or PE-related death within three months of enrolment. Secondary outcomes include quality of life and patient satisfaction, and health care resource utilisation compared to existing data on standard-duration hospital treatment. HoT-PE is planned to analyse 1,050 enrolled patients, providing 80 % power to reject the null hypothesis that the recurrence rate of venous thromboembolism is >3 % with α≤0.05. If the hypothesis of HoT-PE is confirmed, early discharge and out-of-hospital treatment may become an attractive, potentially cost-saving option for a significant proportion of patients with acute PE. PMID:27010343

  15. La casa y el ajuar de la familia Coronel a través de un inventario de bienes del siglo XVI

    Directory of Open Access Journals (Sweden)

    De la Peña Barroso, Efrén

    2015-12-01

    Full Text Available In the last years we have been working on the person of don Abraham Seneor/Fernán Pérez Coronel and his offspring, mainly from his son Íñigo López Coronel. In this occasion we will focus on the structure of the dwelling house and the household goods of the family through an inventory made in Segovia in 1522. This document will allow us to know the wealth level, the shy investment in luxury goods and the list of part of the household goods of this important family of Segovian conversos.Desde hace ya varios años estamos trabajando en la figura de don Abraham Seneor/Fernán Pérez Coronel y su descendencia, sobre todo por la vía de su hijo Íñigo López Coronel. En esta ocasión, estudiaremos la estructura espacial de su casa, sus bienes muebles y el ajuar de esta rama familiar a través de un inventario de bienes realizado en sus «casas principales» de la ciudad de Segovia en el año 1522. Este inventario nos permitirá acercarnos a los niveles de riqueza, a la escasa inversión en productos de lujo y al conocimiento de gran parte del ajuar de esta importante familia de judeoconversos segovianos.

  16. La repercusión del valor razonable de los bienes inmuebles en la utilidad de los estados financieros: una nota de investigación

    Directory of Open Access Journals (Sweden)

    Andrés Navarro Galera

    2009-01-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.

  17. Gasto particularista en bienes públicos locales: índice de desviación Particularistic expenditure on local public goods: an index of deviation

    Directory of Open Access Journals (Sweden)

    María Alejandra Armesto

    2012-09-01

    Full Text Available El gasto particularista del gobierno se opone al gasto programático. Los dos tipos de medidas clasifican los beneficios de políticas como particularistas si son bienes exclusivos o si son explicados por variables políticas. Este artículo desarrolla un índice de gasto particularista en bienes públicos locales medido como desviación con respecto al programa. Se aplica el índice a la oferta de servicios básicos por administraciones subnacionales seleccionadas en México y Argentina. Se muestra que el índice corre menos riesgos de sobreestimar o subestimar el gasto particularista y el gasto programático que las medidas existentes.This article compares particularistic and programmed government spending. The two types of measures classify the benefits of policies as particularistic if they are exclusive goods or if they are determined by political variables. This article contains an index of particularistic expenditure on local public goods, measured as a deviation from the program. It applies this index to the supply of basic services from selected sub-national administrations in Mexico and Argentina. It shows that this index is less likely to over- or under-estimate particularistic and programmatic expenditure than existing measures.

  18. L’addiction ou les addictions ; en quête d'un bien-être et pathologie de système ?

    Directory of Open Access Journals (Sweden)

    Thierry Jandrok

    2016-04-01

    Full Text Available Dans le cadre de cet article nous reviendrons sur le sens du terme d’«addiction» qui remplaça, il y a quelques années, celui de «toxicomanie». De nos jours, le discours politiquement correct ne stigmatise plus. Il ne présente plus, n’accuse plus. Il culpabilise et met l'accent sur la fonction consommatrice et la relation d’un individu aux pratiques et aux productions des plaisirs. On parle désormais d'usager, de consommateur. Ce personnage décrit par la vulgate contemporaine est distinctement inclus dans le système marchand des biens et des services. Que cachent ces arguties lexicales ? Quelle est le sens de cette démarche économico-politique qui privilégie la fonction sur le sujet ? Quel est donc ce clivage dans la définition de pratiques qui, bien que collectives, n'en restent pas moins singulières et, par conséquent, inaliénables ? L'addiction n'existe pas sans un référentiel théorique, politique et économique, sans un background à partir duquel certains sens se créent et s'échangent. Dans ce mouvement, l’addiction tend à s’effacer, en même temps que la subjectivité, derrière une brume sémantique qui hésite entre la stigmatisation de pratiques pathologiques singulières et comportements transgressifs, apparemment détachés des échanges. Dans ce cadre, nous interrogerons ces théories qui du semblant et de l’apparence proposent un sens à une fonction au détriment de ceux qui pourraient l’habiter ? Comment le sujet est-il déshabillé de sa consistance, de ses souffrances, de sa jouissance, et finalement de sa quête de bien-être ou de mal-être, au profit de discours qui n’entendent que l’enchaînement des actes comme preuves de qui il serait ? Le retrait de la composante maladive de l’addiction a dénaturé sa réalité. Sans la notion de mal ou le concept de maladie, comment faire valoir le bien et par conséquent redonner sens à la notion de «bien-être» ? Les lumières des discours

  19. La opacidad de los acuerdos generales de bienes y servicios en España Opacity of general agreements on goods and services in Spain

    Directory of Open Access Journals (Sweden)

    Román Andrés Umaña Peña

    2006-06-01

    Full Text Available Objetivo: Explorar la intensidad del debate parlamentario sobre el Acuerdo General de Comercio de Servicios (AGCS asumido por España ante la Organización Mundial del Comercio (OMC, y compararla con la del Acuerdo General de Bienes (GATT. Métodos: Búsqueda sistemática y análisis del contenido de todas las iniciativas parlamentarias sobre AGCS y GATT realizadas entre 1979 y 2004 en el Congreso de los Diputados y el Senado. Se calculó la frecuencia y porcentaje de iniciativas parlamentarias de ambos temas, resultado de su tramitación y tipo de iniciativa. Resultados: Se presentaron 185 iniciativas parlamentarias sobre los acuerdos multilaterales de bienes y servicios, de las que 120 se referían al GATT, 8 al AGCS y 57 a ambos acuerdos. La mayoría de las iniciativas no fueron discutidas (GATT, 71%; GATS, 55,4% o estuvieron sujetas a un debate político en el que apenas se dieron intervenciones por parte de los grupos parlamentarios. Conclusiones: A pesar de las implicaciones del acuerdo multilateral de servicios para la política sanitaria española, éste se ha asumido con escaso debate parlamentario previo, incluso menos que en el caso de su homólogo sobre bienes. Se requiere en este tema una intensificación de la función de control al gobierno.Objective: To explore the intensity of the debate in the Spanish Parliament on the General Agreement on Trade in Services (GATS developed by Spain and the World Trade Organization, and to compare it with the debate on the General Agreement on Tariffs and Trade (GATT. Methods: A systematic search and content analysis were performed of all parliamentary initiatives on GATS and GATT undertaken from 1979 to 2004 in the Spanish Parliament and Senate. The frequency and percentages of initiatives on both issues were calculated, and the final result and kinds of initiative were analyzed. Results: A total of 185 initiatives were presented in the Spanish Parliament on these agreements, of which 120 were

  20. Producción y percepción de bienes públicos en la lógica de la acción colectiva

    Directory of Open Access Journals (Sweden)

    Jordana, Jacint

    2007-04-01

    Full Text Available Public goods having different proprieties produce different problems of collective action. This hypothesis has been discussed from different analytical perspectives and we examine their arguments, aiming to deepen our theoretical understanding about the logic of collective action. In this paper we look for similarities and differences regarding their use of concepts and expected results. Simultaneously, we examine the link between different public goods and the interdependent behavior of individuals. To this purpose, we also revisit the connections between production functions and consumption types in the case of public goods, as a mean to explore the potential development of more elaborated models in the theory of collective action, and suggest that more empirical contrast of these models is needed. Finally, we argue the importance for theoretical discussions to include a discussion about the impact of perception in the collective action models, considering systematic deviations to rational choice, and conclude that no single theory may address all collective action problems, but systematic patterns of behavior may be identified and empirically confirmed.

    Bienes públicos con distintas propiedades generan problemas diferentes de acción colectiva. Esta hipótesis ha sido discutida, desde distintas perspectivas analíticas, con el objeto de profundizar teóricamente sobre la lógica de la acción colectiva. En este trabajo se revisan las aportaciones recientes a esta cuestión, analizando sus puntos de encuentro y sus divergencias en cuanto a conceptos y resultados esperados. Asimismo, se examina la relación entre tipos distintos de bienes públicos y el comportamiento interdependiente de los individuos. Con este fin, los vínculos entre las funciones de producción y las formas de consumo de bienes públicos también son considerados, ya que permite desarrollar modelos más ambiciosos sobre la lógica de la acción colectiva. Finalmente

  1. Monitoring low molecular weight heparins at therapeutic levels: dose-responses of, and correlations and differences between aPTT, anti-factor Xa and thrombin generation assays.

    Directory of Open Access Journals (Sweden)

    Owain Thomas

    Full Text Available Low molecular weight heparins (LMWH's are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa, activated partial thromboplastin time (aPTT and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.To examine the effects of two different LMWH's on the results of 4 different aPTT-tests, anti-FXa activity and thrombin generation and to assess the tests' concordance.Enoxaparin and tinzaparin were added ex-vivo in concentrations of 0.0, 0.5, 1.0 and 1.5 anti-FXa international units (IU/mL, to blood from 10 volunteers. aPTT was measured using two whole blood methods (Free oscillation rheometry (FOR and Hemochron Jr (HCJ and an optical plasma method using two different reagents (ActinFSL and PTT-Automat. Anti-FXa activity was quantified using a chromogenic assay. Thrombin generation (Endogenous Thrombin Potential, ETP was measured on a Ceveron Alpha instrument using the TGA RB and more tissue-factor rich TGA RC reagents.Methods' mean aPTT at 1.0 IU/mL LMWH varied between 54s (SD 11 and 69s (SD 14 for enoxaparin and between 101s (SD 21 and 140s (SD 28 for tinzaparin. ActinFSL gave significantly shorter aPTT results. aPTT and anti-FXa generally correlated well. ETP as measured with the TGA RC reagent but not the TGA RB reagent showed an inverse exponential relationship to the concentration of LMWH. The HCJ-aPTT results had the weakest correlation to anti-FXa and thrombin generation (Rs0.62-0.87, whereas the other aPTT methods had similar correlation coefficients (Rs0.80-0.92.aPTT displays a linear dose-response to LMWH. There is variation between aPTT assays. Tinzaparin increases aPTT and decreases thrombin generation more than enoxaparin at any given level of anti-FXa activity, casting doubt on anti-FXa's present gold standard status. Thrombin generation with tissue factor-rich activator is a promising method for monitoring LMWH's.

  2. L’évocation des biens communs dans les revendications citoyennes contre le gaz de schiste au Québec

    OpenAIRE

    Goupil, Sylvie

    2016-01-01

    Le présent article s’interroge sur l’action citoyenne et plus particulièrement sur ce qui peut pousser des personnes, qui ont toujours vécu dans un « anonymat politique », à se lancer dans une action publique qui interpelle les gouvernements. L’auteure prend pour point de départ la conception selon laquelle des préoccupations vécues dans la vie quotidienne sont à l’origine d’une prise de conscience quant à un problème qui concerne ce que les acteurs identifient comme des biens communs. Elle i...

  3. Les représentations de l’animal et du bien-être animal par les éleveurs français

    OpenAIRE

    Dockes, Anne-Charlotte; Kling-Eveillard, Florence

    2007-01-01

    Plusieurs travaux récents ont permis d’appréhender les représentations des éleveurs, vis-à-vis de l’animal et du bien-être animal. Ils mettent en évidence un certain nombre d’éléments communs à tous les éleveurs : la place centrale de l’animal dans la définition du métier, la relation professionnelle aux animaux, le rôle central de l’observation dans le métier d’éleveur… Ils montrent la diversité des représentations de l’élevage, des animaux d’élevage et des pratiques, en fonction du type d’a...

  4. Les caractéristiques du climat forestier et son influence sur le bien-être: le cas de l'été 2003 en Suisse

    OpenAIRE

    Läderach, Sabina; Rebetez, Martine

    2007-01-01

    Les dernières décennies ont été caractérisées par le dépassement régulier du record des périodes les plus chaudes depuis le début de l’enregistrement des mesures météorologiques et il devient de plus en plus clair que nous devrons apprendre à faire face à des situations de canicule de plus en plus fréquentes. Est-ce que la forêt peut jouer un rôle favorable pour notre bien-être dans ce contexte? L’enjeu de ce mémoire est de répondre à cette question. Cela dans un premier temps en comparant le...

  5. Perspectivas del crecimiento urbano: la actividad comercial minorista y el transporte de bienes en la Zona Metropolitana de Querétaro (México

    Directory of Open Access Journals (Sweden)

    Eduardo Betanzo-Quezada

    2015-01-01

    Full Text Available Se muestran las perspectivas del crecimiento urbano, la actividad comercial minorista y su relación transversal con el transporte de bienes en la Zona Metropolitana de Querétaro (México. Con una metodología de análisis de información estadística de tipo agregado, se examinan esos determinantes con el objetivo de revelar sus tendencias en la ciudad. El paralelismo encontrado en las tendencias de comportamiento de los determinantes examinados conduce a concluir que es cada vez más necesario conectar al transporte urbano de carga con la planeación económica y urbana, y ubicarlo dentro de las prioridades de las administraciones gubernamentales.

  6. Industrial 800xA系统在无缝钢管生产中的应用%Application of Industrial 800xA System in Seamless Tube Mill

    Institute of Scientific and Technical Information of China (English)

    李建军; 余志伟; 王歌; 刘占国

    2009-01-01

    Application of ABB Industrial 800xA System in Seamless Tube Mill is described,including technological process,system configuration,software function and performance analysis etc.The automation level,productivity and control accuracy in seamless tube are extremely improved by using Industrial 800xA system,stability and reliability of production are ensured as well.%介绍ABB Industrial 800xA系统在无缝钢管生产领域中的应用,主要包括工艺流程、系统配置、软件控制功能、性能分析等内容.该系统的使用显著地提高了缝钢管生产的自动化控制水平,有效地提升了生产节奏和控制精度,生产的稳定性和可靠性得到了有效保障.

  7. ¿qué papel juega la definición de la eudaimonía en la concepción del bien humano de aristóteles?

    OpenAIRE

    Velásquez, Beatríz Alejandra

    2012-01-01

    Aristóteles propone una concepción del bien humano que determina (hasta con un cierto grado de precisión) cómo hemos de ser, actuar y en general vivir. Tal concepción se logra, según él, definiendo el bien humano, y en EN 1.7 lo define como “una actividad del alma según la virtud”. Esta definición no brinda información acerca de cómo ser y actuar, por lo que parece no contener la concepción esperada del bien, lo cual sí logra la teoría de la virtud presentada en libros posteriores. ¿Qué papel...

  8. La Repercusión del Valor Razonable de los Bienes Inmuebles en la Utilidad de los Estados Financieros: Una Nota de Investigación

    Directory of Open Access Journals (Sweden)

    Andrés Navarro Galera

    2009-06-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.The option in the recent Spanish regulation for fair value over historical cost, as the preferred measurement basis for some assets, has raised some controversy. This paper studies the effects on accounting information relevance and reliability of fair value accounting for investment properties. The empirical study is based on a questionnairebased survey of the perceptions of 151 Spanish accountants in the building industry about the usefulness and reliability of fair value accounting. The analysis of results allows us concluding that accountants perceive that the usefulness of financial statements increases when investment property is valued on a fair value basis, compared with a historical cost basis. However, respondents

  9. Aspectos generales del régimen de los bienes del litoral marítimo. Competencias y limitaciones sobre el Derecho de propiedad

    Directory of Open Access Journals (Sweden)

    Sebastián Barreto Cifuentes

    2013-06-01

    Full Text Available El concepto de “propiedad”, tradicionalmente estudiado con la lógica del Derecho privado, ha sufrido cambios internos (la función social como núcleo esencial y externos (las limitaciones administrativas que hacen necesario estudiarlo con herramientas lógicas y metodológicas del Derecho público. Se debe considerar que un derecho absoluto e ilimitado no requiere mayor atención por parte de la disciplina del Derecho público. La armonización y articulación de los derechos del propietario con las competencias asignadas a las autoridades administrativas, exige una particular atención para proteger los derechos ciudadanos. En desarrollo de lo mencionado, se ha realizado un corto estudio sobre los bienes del litoral marítimo, en particular de las competencias asignadas a las autoridades administrativas sobre estas áreas, así como el límite de estas competencias. También se presentará el análisis de algunos casos reales y potenciales en los cuales se hace necesaria la aplicación de garantías procesales y sustanciales para el respeto de los derechos de los propietarios.

  10. Aspectos generales del régimen de los bienes del litoral marítimo. Competencias y limitaciones sobre el Derecho de propiedad

    Directory of Open Access Journals (Sweden)

    Sebastián Barreto Cifuentes

    2013-07-01

    Full Text Available El concepto de “propiedad”, tradicionalmente estudiado con la lógica del Derecho privado, ha sufrido cambios internos (la función social como núcleo esencial y externos (las limitaciones administrativas que hacen necesario estudiarlo con herramientas lógicas y metodológicas del Derecho público. Se debe considerar que un derecho absoluto e ilimitado no requiere mayor atención por parte de la disciplina del Derecho público. La armonización y articulación de los derechos del propietario con las competencias asignadas a las autoridades administrativas, exige una particular atención para proteger los derechos ciudadanos. En desarrollo de lo mencionado, se ha realizado un corto estudio sobre los bienes del litoral marítimo, en particular de las competencias asignadas a las autoridades administrativas sobre estas áreas, así como el límite de estas competencias. También se presentará el análisis de algunos casos reales y potenciales en los cuales se hace necesaria la aplicación de garantías procesales y sustanciales para el respeto de los derechos de los propietarios.

  11. Producción y consumo de bienes culturales: El caso de las artesanías urbanas de la Ciudad de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Mónica B. Rotman

    2002-12-01

    Full Text Available Este artículo tiene por objeto reseñar algunos de los principales aspectos de un fenómeno cultural citadino: las artesanías urbanas feriales de la Ciudad de Buenos Aires. La problemática abordada contempla las instancias de la producción artesanal, la circulación de estos bienes con énfasis en las Ferias como sitios privilegiados del intercambio y ámbitos relevantes de sociabilidad y el consumo de artesanías. Consideramos que este tipo de producción, que constituye un fenómeno complejo, conforma una práctica cultural heterodoxa, recreando con códigos propios la sociabilidad híbrida que inducen las ciudades contemporáneas.The objective of this article is to outline some of the main aspects of an urban cultural phenomenon: the urban handicrafts from fairs in Buenos Aires city. The issues this paper addresses are handicraft production, the circulation of these goods with emphasis on fairs as privileged places of exchange, sociability and handicraft consumption. I consider this type of production a complex phenomena that shapes an heterodox cultural practice, recreating through its own codes the hybrid sociability that contemporary cities induce.

  12. Los bienes de interés cultural de Gáldar (Canarias y el conjunto histórico “Plaza de Santiago” (1981-2006

    Directory of Open Access Journals (Sweden)

    Juan Sebastián López García

    2013-10-01

    Full Text Available En 1981, hace veinticinco años, la zona central de Gáldar fue declarada “Conjunto Histórico Artístico” con la denominación de Plaza de Santiago. Sin embargo no era el primer bien cultural que obtenía una distinción de este tipo, ya que Gáldar había sido pionera en 1949 con el yacimiento de El Agujero y La Guancha, primero de los de carácter arqueológico declarado en Canarias, al que seguiría en 1972 la Cueva Pintada. Hasta la década de los setenta prevalecieron los bienes arqueológicos, situación que se modificó en las dos últimas décadas del siglo XX después del reconocimiento de la Plaza de Santiago y su entorno. Junto con edificaciones religiosas también se incluyeron ejemplos de arquitectura doméstica, completándose con algunos yacimientos prehispánicos. Una particular circunstancia fue la declaración en 1993 del pago de Barranco Hondo de Abajo, lo que convertía a Gáldar en el primer municipio de Canarias que contaba con dos conjuntos históricos, siendo éste a la vez el primero de la comunidad autonóma con características rurales. De la relación de los declarados, si exceptuamos la mayoría de los de carácter arqueológico, buena parte son urbanos. Una característica es que se incluyen categorías variadas, incluyendo la existencia de una zona arqueológica junto a un conjunto histórico y varios monumentos (de arquitectura religiosa y doméstica. Este hecho es lógico si se tiene en cuenta la particularidad de Gáldar y su condición de núcleo histórico de superposición.Twenty five years ago, in 1981, the central zone of Galdar was declared an "Historic Artistic Site" with the name of Plaza de Santiago. But this was not the first cultural asset to obtain a distinction of this kind, as Galdar pioneered protection of this kind with the El Agujero and La Guancha site, the first archaeological site declared in the Canary Islands, followed by La Cueva Pintada, in 1972. Archaeological assets prevailed up

  13. La evolución de las exportaciones de bienes de China: una visión panarómica = Chinese goods exports development: An overview

    Directory of Open Access Journals (Sweden)

    Ana Salvador Chamorro

    2014-07-01

    Full Text Available Resumen El proceso de reforma económica que ha experimentado la economía de China es uno de los fenómenos de mayor relevancia en la evolución de la Economía Mundial en los últimos treinta años y, sin duda, seguirá siéndolo en el futuro. Dentro de este proceso, la apertura al exterior, que el gobierno chino inició en 1978, ha situado al país en un lugar de máxima relevancia dentro de los flujos comerciales y financieros internacionales. En este contexto, el objetivo de este trabajo es intentar realizar un análisis general de la evolución del comercio exterior de China en las últimas décadas, prestando especial atención a sus exportaciones de bienes y poniendo énfasis en los cambios experimentados durante los últimos años. Abstract The process of economic reform that has experienced the Chinese economy is one of the most important events in the evolution of the World Economy in the past 30 years, and will undoubtedly remain so in the future. Within this economic reform, the opening process that the Chinese Government began in 1978, has put the country in a place of utmost importance in the international trade and financial flows. In this context, this paper try to perform an analysis of the evolution of China's foreign trade in recent decades, with particular attention to its exports and emphasizing the changes in recent years.

  14. L’apprentissage du bien-être animal chez de futures professionnels animaliers : des éthiques animals malmenées

    Directory of Open Access Journals (Sweden)

    Vidal Michel

    2015-01-01

    Full Text Available Les débats dont le bien-être animal est l’objet entre chercheurs, professionnels et associations en font une question socialement vive scientifico-éthique. Ils en interrogent l’éducabilité alors que cette notion est prise en compte dans les curricula de l’enseignement agricole. Envisageant son enseignement au travers d’une éducation à l’empathie interspécifique, nous questionnons les facteurs susceptibles de l’influencer. Nous nous fondons sur le discours de sept élèves en baccalauréat professionnel relevant de l’élevage d’animaux de production ou d’animaux de compagnie durant deux années de formation. Six élèves, quelle que soit leur filière de formation, souhaitent créer une relation affective sans nécessairement développer une attitude empathique durant la formation. Parmi les facteurs responsables, nous distinguons (1 un manque de confiance en soi de l’élève, (2 des motivations égocentrées primant sur des motivations zoocentrées, (3 la loyauté et les habitudes acquises à l’égard des pratiques parentales, (4 la conformation aux pratiques et idéologies dominantes du monde professionnel, (5 des facteurs associés aux situations d’enseignement (savoirs et pratiques de référence qui font autorité, valeurs de conformité primant sur des valeurs éthiques, dissociation de la dimension relationnelle et productive de l’élevage, jugements négatifs portés par l’enseignant et les élèves originaires du monde agricole. Ces facteurs généreraient des mécanismes de défense chez l’élève nuisibles au développement d’un raisonnement affectivo-éthique critique.

  15. 体积排阻色谱法测定低分子量肝素抗凝血因子Xa的活性%An assay for anti-factor Xa activity of low molecular weight heparins by high performance liquid size exclusion chromatography

    Institute of Scientific and Technical Information of China (English)

    张倩倩; 康经武

    2013-01-01

    发展了一种基于体积排阻色谱测定低分子量肝素(LMWH)抗凝血活性的方法.利用肝素与抗凝血酶Ⅲ(ATⅢ)结合后可增强ATⅢ对凝血因子Xa (FXa)抑制作用的原理,通过测定加入LMWH后FXa水解其生色底物产生对硝基苯胺(pNA)这一反应的抑制程度确定LMWH的活性.首先将含有一定浓度LMWH的缓冲溶液与ATⅢ溶液混合,然后依次加入FXa和生色底物,分别孵育一段时间.底物被FXa水解,产生游离的pNA.体积排阻色谱可将小分子产物pNA与其他大分子分离开,因而可以在pNA的最大吸收波长下得到高灵敏度的测定,并且不再受其他成分的干扰.该方法重复性好,灵敏度高,极大地减少了样品的消耗量,降低了成本,并且还可进行各种复杂样品(如血浆)中LMWH抗FXa活性的监测.%The "gold standard" assay for monitoring low molecular weight heparins (LMWHs) activity is the chromogenic-based anti-factor Xa assay.The methodology of an anti-factor Xa assay is that LMWH is added to a known amount of excess factor Xa and excess antithrombin.It will bind to antithrombin and form a triplet complex with factor Xa,inhibiting the activity of factor Xa.However,the residual factor Xa can still hydrolyze chromogenic peptide substrate,releasing the chromophore for photometric detection.The absorbance is inversely proportional to the amount of heparin/LMWH.The results are given in anticoagulant concentration in units/ mL of anti-factor Xa,such that high values indicate high levels of anticoagulation and low values indicate low levels of anticoagulation.Herein,a novel assay method for anti-FXa activity of LMWHs using high performance liquid size exclusion chromatography (SEC) is reported,in which antithrombin m (AT m) was diluted by the buffer solution contained LMWHs.Subsequently,exogenous FXa and p-nitroaniline coupled peptide substrate were added and incubated for a period,separately.The resulting mixture was separated based on size by SEC

  16. Conflictos por la herencia de bienes vinculados: Mujeres nobles pleiteando Conflicts for the inheritance of linked goods: Noble women going to law

    Directory of Open Access Journals (Sweden)

    Marcela Correa Barboza

    2012-12-01

    Full Text Available La casa, el parentesco, la clientela son vínculos que estructuran a conjuntos de individuos relacionados entre ellos, permitiéndoles actuar como agentes sociales colectivos. En las sociedades alto-modernas, de carácter patriarcal, las mujeres se encontraban supeditadas a la autoridad del varón, siendo éste quien actuaba socialmente, estableciendo diferentes vínculos entre familias, parientes, etc; relaciones a las que las mujeres quedaban sujetas en gran medida. Sin embargo, la historia de las mujeres ha mostrado que ellas tenían un accionar muy activo, eran capaces de intervenir en los vínculos ya existentes de manera decisiva, entablaban alianzas y promovían importantes redes de relaciones, que muchas veces encabezaban. En los últimos veinte años, se han puesto de relieve nuevas fuentes y nuevas categorías que enriquecen los estudios y propician otras formas de mirar la documentación. La utilización de la categoría género en el análisis ha permitido redimensionar el lugar de las mujeres en la historia. En los casos que presentaremos y en los temas que abordaremos, podremos observar las formas en que las mujeres de la muy alta nobleza actúan como verdaderas cabeza de linajes, defendiendo intereses propios, pero sobre todo colectivos - los de su familia-, buscando en los vericuetos legales las formas de conseguir cierto patrimonio, de mantenerlo en su círculo más cercano y, al mismo tiempo, de aumentarlo si consideran la posibilidad de acceder a nuevos bienes a través de herencias, compras, intercambios, etc.The house, kinship, the clientele are links that structure to sets of individuals related to each other, enabling them to act as collective social agents. In high-modern societies, the patriarchal nature, women were subject to male authority, this being who acted socially, establishing links between different families, relatives, etc., relations which women were subject to a great extent. However, women's history has

  17. Comparative physical mapping of rice BAC clones linked to resistance genes Glh,Bph-3 and xa-5 in Oryza sativa L.and O.granulata Nees et Am.ex Watt.

    Institute of Scientific and Technical Information of China (English)

    XIONG Zhiyong; TAN Guangxuan; YOU Aiqing; HE Guangyuan; SHE Chaowen; LI Lijia; SONG Yunchun

    2004-01-01

    Oryza granulata Nees et Arn. ex Watt. is one of the three wild relatives of rice, which are the most valuable for study and utilization in China. In this study, the homology and physical locations of three rice resistance genes, Glh,Bph-3 and xa-5 are comparatively analyzed between O. sativa and O. granulata by Southern blotting and fluorescence in situ hybridization (FISH). The results of Southern blotting indicate that there exist homologous sequences of the tested RFLP markers in O. granulata. By using three bacterial artificial chromosome (BAC) clones scanned by the tested RFLP as probes, FISH signals are detected on both mitotic and pachytene chromosomes in O. sativa and O. granulata.Dual-color FISH demonstrates that two of the three BAC clones (14E16 and 38J9) are located on the short arm of the same chromosome pair in O. granulata. Additionally, colinearity is shown for the two clones between O. sativa and O.granulata. Another BAC clone 44B4 is located on the end of the short arm of other chromosome pair in these two species.Although the phylogenetic relationship between O. sativa and O. granulata is the most distinct in Oryza and these two species have evidently different biological features and ecological habits, the relative lengths and arm ratios of the detected chromosomes and the relative positions of the tested clone signals on chromosomes in O. granulata are quite similar to those in O. sativa.

  18. Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Donald J.P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexander, Richard S.; Smallwood, Angela; Wong, Pancras C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; He, Kan; Xin, Baomin; Wexler, Ruth R.; Lam, Patrick Y.S. (BMS)

    2010-03-08

    Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a primary aniline. Cyclization of the carboxamido linker to the novel bicyclic tetrahydropyrazolopyridinone scaffold retained the potent fXa binding activity. Exceptional potency of the series prompted an investigation of the neutral P{sub 1} moieties that resulted in the identification of the p-methoxyphenyl P{sub 1}, which retained factor Xa binding affinity and good oral bioavailability. Further optimization of the C-3 pyrazole position and replacement of the terminal P{sub 4} ring with a neutral heterocycle culminated in the discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, compound 40). Compound 40 exhibits a high degree of fXa potency, selectivity, and efficacy and has an improved pharmacokinetic profile relative to 4.

  19. Metástasis pulmonar miliar como primera manifestación de carcinoma de tiroides bien diferenciado en niños

    Directory of Open Access Journals (Sweden)

    Karol Federico

    2005-02-01

    Full Text Available Objetivo: Presentar el caso de una adolescente con manifestaciones de afectación pulmonar como motivo de consulta, debido a una metástasis pulmonar miliar de carcinoma (Ca papilar de tiroides. Caso Clínico: Se trata de una adolescente femenina de 13 años de edad quien presenta tos seca, disnea de esfuerzo, palpitaciones, dolor precordial, y pérdida de peso de 15 días de evolución. Al examen clínico se evidencia aumento de volumen de la región anterior del cuello a predominio izquierdo, con adenopatía cervical palpable, acrocianosis y cianosis peribucal. Hematología completa, función tiroidea y electrocardiograma normales. La gasometría arterial demuestra una hipoxemia severa. En Rx. de tórax se observa infiltrado miliar micro y macronodular bilateral. En ultrasonido impresionan adenopatías de ubicación pretraqueal y paracarotideas. Tomografía de cuello revela imagen altamente sugestiva de malignidad en lóbulo tiroideo izquierdo y tomografía toraco-abdominal muestra infiltrado pulmonar bilateral micronodular sugestivo de lesiones metastásicas. Estudio histopatológico de ganglio latero cervical izquierdo reporta metástasis de Ca papilar tiroideo a predominio de estructuras foliculares. Se hace diagnóstico de carcinoma papilar bien diferenciado de tiroides con metástasis a región pulmonar, se realiza tiroidectomía total y control de T4L y TSH a los 30 y 60 días post cirugía, con valores normales de T4L y ligeramente aumentados de TSH (7 uU/ml, planteándose metástasis pulmonares funcionantes. Se indica terapia ablativa con I131 presentando evolución clínica estable, pero con cifras de 300 mg/dL de tiroglobulina a los seis meses, por lo que se planifica otra sesión con radioyodo. A propósito de este caso, el segundo en cinco años en la Unidad de Endocrinología del IAHULA, se lleva a cabo una revisión de la literatura sobre esta entidad nosológica. Conclusiones: En niños, el Ca papilar de tiroides puede ponerse

  20. Efecto del subprograma de apoyo a los proyectos de inversión rural (PAPIR) en productores que recibieron bienes de capital durante el periodo 2002-2007 en la Región Libres, Puebla, México.

    OpenAIRE

    Soto Reyes, Vianey

    2012-01-01

    El Subprograma de Apoyo a los Proyectos de Inversión Rural (PAPIR), fue un programa diseñado para fomentar la inversión en bienes de capital de la población rural elegible a través del apoyo para la puesta en marcha de proyectos productivos que posibiliten la aplicación de tecnologías apropiadas, la reconversión productiva, el acopio, acondicionamiento y transformación para fortalecer la comercialización de la producción primaria, la generación de empleo rural y de servicios, así como su posi...

  1. Aplicaciones de la tecnología de microondas a la desinsectación en los sectores: Cárnico y de restauración de bienes culturales

    OpenAIRE

    Zona Ortiz, Angela Tatiana

    2008-01-01

    Esta investigación amplia el campo de aplicación para el calor producido por las microondas en el área de desinsectación dentro de los sectores cárnico y de restauración de bienes culturales. Estableciendo un procedimiento inicial de aplicación que permita la conservación del material a desinsectar (jamón curado y madera), mientras se eliminan los agentes contaminantes (ácaros y carcoma). El objetivo que se persigue es la desinsectación segura, no invasiva y medioambientalmente limpia. La...

  2. Aproximación a la lectura de bienes patrimonializados de la arquitectura racional del s.XX desde la “Dialéctica de la mirada” de Walter Benjamin

    OpenAIRE

    Cuello, Juan Nicolás

    2010-01-01

    En el marco del estudio de las posibles dimensiones epistemológicas del arte, lo que pretendo en este trabajo es abordar una aproximación a las consideraciones que se podrían realizar acerca de la arquitectura moderna o racional, y sobretodo aproximarme a una lectura de esta propuesta estilística desde la metodología desarrollada por Benjamin en su investigación sobre los Pasajes de Paris, conocida como Dialéctica de la mirada. Para ello tomare como ejemplos paradigmáticos dos bienes que son ...

  3. Éduquer au bien-être animal en formation professionnelle : prise en compte de l'empathie interspécifique par le système éducatif

    OpenAIRE

    Vidal, Michel

    2014-01-01

    Les débats scientifico-éthiques relevant du bien-être animal en font une question socialement vive. Nous interrogeons son enseignement en formation agricole, envisagé au travers d'une éducation à l'empathie interspécifique. Nous questionnons les facteurs des éducations formelle, non-formelle et informelle susceptibles de le défavoriser. Notre recherche se fonde sur les discours de 7 élèves en formation relevant de l'élevage d'animaux de production ou d'animaux de compagnie, de 5 enseignants e...

  4. Riesgos en el proceso de importación ordinaria: identificación del mapa de riesgos de la importación de bienes de capital en Colombia

    OpenAIRE

    Gallón Perdomo, Sara María; Torres Muskus, Carlos Henrique

    2014-01-01

    En Colombia, durante el proceso de importación se presentan diversos riesgos, que pueden implicar desde sobrecostos hasta la pérdida de la mercancía -- Considerando que las importaciones son necesarias en las empresas, en la presente investigación se elabora un mapa de riesgos del proceso de importación ordinaria de bienes de capital en el país, con el fin de identificarlos, de tal manera que los importadores estén informados y puedan aplicar los métodos de control pertinentes para la adm...

  5. Salud e Internet o cómo conseguir pacientes crónicos bien informados y autónomos: el caso del EAP Mataró-6 (Barcelona, Cataluña)

    OpenAIRE

    Boté, Clara; Vall Casas, Aurora

    2012-01-01

    La consolidación progresiva del uso de las TIC en la sociedad actual así como el libre acceso a gran cantidad de información sobre salud en Internet, favorecen la aparición de pacientes activos y colaboradores. La relación "profesional sanitario-paciente" está evolucionando hacia un nuevo modelo en el cual se proporciona información adecuada y de calidad para conseguir pacientes expertos, bien informados y autónomos. En Cataluña, el personal de enfermería de atención primaria desarrolla funci...

  6. Ivonne Farah H. / Luciano Vasapollo (Coordinadores), Vivir Bien: ¿Paradigma no capitalista?, Universidad Mayor de San Andrés(CIDES-UMSA) y Departamento de Economía de la Universidad de Roma La Sapienza, 2011, 437 p.

    OpenAIRE

    Perea Sandoval, Carlos

    2013-01-01

    La humanidad se encuentra en una constante búsqueda por construir una ética que permita hacer realidad el re-ligarse con el futuro, lo cual implica generar una convivencia recíproca con la naturaleza y las demás formas de vida, en el camino de la ética del bien común. La construcción de este modelo ético se constituye en una prioridad ya que desde el mismo es posible determinar caminos de acción, que a partir de una postura social y de apoyo mutuo, se concrete en alternativas para enfrentar e...

  7. Tercer Premio del I Concurso de monólogos científicos de la Facultad de Ciencias del Mar y Ambientales. Saber comer para crecer muy bien. La teoría endosimbiótica

    OpenAIRE

    Rodríguez López, Jaime; Cabrera Castro, Remedios; López López, José Antonio; Albendín García, Gemma

    2015-01-01

    La teoría endosimbiótica fue propuesta por Lynn Margulis en 1967 y como tantas otras al principio no fue bien valorada por los científicos. Esta teoría plantea esencialmente que algunos de los orgánulos de las células eucariotas, en particular las mitocondrias y los plastos, fueron en su momento organismos procariontes de vida libre (bacterias), que probablemente tras haber sido fagocitadas no fueron digeridas llegando a formar parte y creando una relación dependiente de la célula que las fag...

  8. La participación como bien de consumo : una aproximación conceptual a las formas de implicación de los usuarios en proyectos audiovisuales colaborativos

    OpenAIRE

    Roig Telo, Antoni

    2010-01-01

    Este artículo centra su atención en el concepto de participación, ampliamente utilizado —y también discutido— para hacer referencia a la implicación de los usuarios en la creación de contenidos audiovisuales en Internet. Particularmente, nos centraremos en la noción de participación de los públicos en el diseño, desarrollo y difusión de productos audiovisuales complejos, como por ejemplo largometrajes, webseries o proyectos ‘crossmedia’. Si bien la mayor parte del debate académico sobre la ca...

  9. Evaluación y análisis de la mejora del servicio de autorización de exportación del Registro de Bienes Culturales de Matanzas

    Directory of Open Access Journals (Sweden)

    Justa Bielka Cantillo González

    2011-04-01

    Full Text Available La presente investigación se realiza en el Registro Provincial de Bienes Culturales de Matanzas, donde se implementa un procedimiento creado por el colectivo de la Cátedra de Calidad de la Universidad de Matanzas “Camilo Cienfuegos” para la evaluación y análisis de la mejora del servicio de autorización exportación de bienes culturales.Para desarrollar la investigación se aplicaron las siguientes herramientas: Diagrama de Flujo, Diagrama Causa-Efecto, Encuesta, Análisis Operacional,  Estadística descriptiva, no paramétrica, y multivariada (paquete estadístico SPSS, versión 15.0, Modelos de Frontera (Software EMS, Software Visio, Instrumento Servqual modificado.Los resultados obtenidos en el estudio permitieron comprobar que de los indicadores gestionados por la organización el indicador más afectado es la eficacia y que existen reservas de eficiencia en las que se debe continuar trabajando. Se realiza el análisis causal de los indicadores afectados y se proponen medidas para la mejora de los mismos.

  10. El derecho de compensación por trabajo doméstico en el régimen de separación de bienes del cc y en la LREMV: análisis comparativo

    OpenAIRE

    Montes Rodríguez, María Pilar

    2015-01-01

    La dedicación exclusiva de unos de los cónyuges al trabajo doméstico le atribuye, en el Código civil español, el derecho a una compensación económica cuando el régimen económico matrimonial es el de separación de bienes. En la LREMV el trabajo doméstico no sólo se considera contribución a las cargas del matrimonio sino que también da lugar a un derecho de compensación Exclusive dedication of one of the spouses to domestic work attributed to him in the Spanish Civil Code, ...

  11. La virtud y el comercio en el pensamiento de Domingo de Soto: las prácticas comerciales, el carácter y el bien común

    OpenAIRE

    Azevedo-Alves, A. (André); Moreira, J M

    2014-01-01

    El artículo ahonda en la obra de Domingo de Soto, teólogo, filósofo y especialista en ética del siglo XVI, y examina su propuesta, basada en la virtud, de una evaluación ética del comercio dentro de un marco aristotélico-tomista que permite la articulación de los negocios y el bien común. Presta particular atención al énfasis fundamental que Soto pone en la distinción entre el comercio como actividad y la conducta específica de las personas que se dedican a la actividad comercial. La distinci...

  12. Valérie Deplaigne, Les femmes nobles dans les conflits de transmission de biens aux lendemains de la bataille d’Azincourt, en pays de droit coutumier français

    Directory of Open Access Journals (Sweden)

    Valérie Deplaigne

    2008-07-01

    Full Text Available Faisant suite à un premier travail de recherche portant sur le patrimoine, l’héritage et la transmission des biens d’une héritière noble à la fin du XVe siècle, ce mémoire de deuxième année de Master a pour ambition de sortir de l’aspect monographique alors embrassé pour tenter une approche comparatiste à partir de l’étude de différents cas. Le cadre chronologique choisi est celui de « l’après-Azincourt », moment propice à la plus grande participation des femmes nobles à la vie publique et à ...

  13. Attitudes et consentement à payer des consommateurs vis-à-vis du bien-être animal : une application au cas de la viande bovine en France et en Espagne

    OpenAIRE

    Weisslinger, Delphine

    2015-01-01

    L’intérêt pour le bien-être animal (BEA) se manifeste de plus en plus dans nos sociétés européennes, et peut conduire à de nouvelles attentes de la part les consommateurs. Cette étude s’intéresse aux attitudes et au Consentement à Payer (CAP) des consommateurs pour de la viande bovine certifiée « respectueuse du BEA », à l’aide d’une enquête menée auprès de 1213 consommateurs répartis dans quatre régions en France et en Espagne. La mesure des degrés d’importance et de confiance accordés à 11 ...

  14. Le bien-être au travail en mutation chez les enseignants - une nouvelle approche guidée par la théorie culturelle et historique de l’activité

    OpenAIRE

    Launis, Kirsti; Koli, Annarita

    2014-01-01

    De nombreuses recherches ont révélé que le stress et l’épuisement au travail des enseignants sont en progression. Il s’agit manifestement d’un grave problème constituant une menace pour leur santé et leur bien-être. Au cours de cette étude, les chercheurs ont mesuré les diverses sollicitations exercées dans le travail d’enseignantes et présenté des propositions pour améliorer leur travail et ses conditions de réalisation. Ces propositions ont été prises en compte dans des programmes de format...

  15. Induced abortion among HIV-positive women in Quang Ninh and Hai Phong, Vietnam

    DEFF Research Database (Denmark)

    Chi, Bùi Kim; Gammeltoft, Tine; Nam, Nguyen Thi Thu;

    2010-01-01

    cross-sectional study was conducted in two provinces of Northern Vietnam. In all 707 HIV-positive women were recruited through collaboration with commune health centres and peer groups. Information was obtained on women's socioeconomic characteristics and pregnancy outcomes before and after HIV......Summary Objectives To explore the decision of induced abortion among HIV-positive women and examine how the decision is associated with socioeconomic characteristics and the availability of comprehensive programmes aiming at preventing mother to child transmission of HIV. Methods A descriptive...... diagnosis. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated to measure the association between socioeconomic characteristics and induced abortion. Results Among women who had been pregnant while being aware of their HIV-positive status, 68% stated having had an induced abortion, whereas...

  16. Síndrome de Rett: 50 años de historia de un trastorno aun no bien conocido Rett syndrome: 50 years' history of a still not well known condition

    Directory of Open Access Journals (Sweden)

    Jaime Campos-Castello

    2007-01-01

    Full Text Available Desde que fue descrito por primera vez por Andreas Rett hace 50 años, el síndrome de Rett (SR ha sido objeto de muchas investigaciones, sin embargo continúa siendo un trastorno aún no bien conocido. Presentamos nuestra propia experiencia y una revisión de la literatura sobre el SR. Se trata de un trastorno del neurodesarrollo, dominante ligado a X, que afecta casi siempre a mujeres, la mayoría de los casos de forma esporádica. El diagnóstico de SR debe hacerse en base a la observación clínica. Las principales características son la aparición de un retraso mental, cambios conductuales, estereotipias, pérdida del lenguaje y, sobre todo, del uso propositivo de las manos, aparición de una apraxia de la marcha, presencia de alteraciones de la respiración y, frecuentemente, crisis epilépticas. Los criterios diagnósticos consensuados internacionalmente son aquí revisados. El SR se debe en la mayoría de casos a mutaciones del gen MECP2, si bien una proporción de casos atípicos puede estar causada por mutaciones de CDKL5, particularmente la variante con epilepsia precoz. Sin embargo, los mecanismos patogénicos moleculares no son bien conocidos, así como la relación entre las mutaciones de MECP2 y otros trastornos del desarrollo. Revisamos también los hallazgos de neuroimagen, neuropatológicos y neurobioquímicos descritos en el SR. Respecto al tratamiento, aparte del sintomático, no hay ninguno que se haya mostrado eficaz. Un trabajo reciente abre perspectivas terapéuticas futuras al haber demostrado mediante un modelo animal de ratón la reversión de los síntomas neurológicos mediante la activación de la expresión de MeCP2.Since it was first described by Andrea Rett 50 years ago, Rett syndrome (RS has been the subject of further investigations, nonetheless it continues to be a not well known condition. Our own experience and an updated literature review on RS is presented. RS is a severe dominant X chromosome

  17. Valoración de bienes rústicos de utilidad pública: La expropiación forzosa por las obras del AVE en la provincia de León

    Directory of Open Access Journals (Sweden)

    María del Pilar Gutiérrez Flórez

    2010-06-01

    Full Text Available Con motivo de la expropiación forzosa de fincas en la provincia de León debido a las obras del Tren de Alta Velocidad, AVE, los propietarios de ochenta y dos fincas de los Ayuntamientos de Villanueva de las Manzanas, Santas Martas y Vega de Infanzones, solicitaron un estudio de valoración alternativo de las mismas para presentarlo, en forma de alegaciones individuales, al Jurado Provincial de Expropiación Forzosa de León, tal y como es su derecho, según la Ley de Expropiación Forzosa, LEF, por su desacuerdo con la oferta de la Entidad Expropiante.En este artículo se presenta el método, se justifican los criterios de valoración, se presentan y analizan los resultados obtenidos y se elaboran las conclusiones a partir de los informes individuales, tras el reconocimiento de los terrenos afectados y su entorno, en base a datos obtenidos bien sea de la propia entidad expropiante bien de la normativa autonómica en vigor en el momento de la expropiación, o bien de la Ley del Suelo 8/2007 en lo referente a la toma de decisiones para el planteamiento de las hipótesis de partida del estudio.Por último, se justifican la tasa del tipo de interés utilizado para la Capitalización de las rentas, en base a normativa vigente o estudios oficiales, y el coeficiente multiplicador del valor de las mismas, según los modelos territoriales de situación respecto a un núcleo urbano, ambos parámetros necesarios para determinar el valor de las parcelas.On the occasion of the necessary expropriation of lands in the province of León due to the works of the High-speed train, AVE (HIGH SPEED TRAIN, the owners of eighty two plots of Villanueva de las Manzanas, Santas Martas and Vega de Infanzones, requested an choice study of valuation of the same ones it to present, in the individual allegations, to the Provincial Juror of Necessary Expropriation of León, as it is your choice, according to the Spanish Law of Necessary Expropriation, LEF, for your

  18. AcAP5蛋白N端片段的表达、纯化与活性评价%Expression, purification and evaluation of N-terminal domain of AcAP5 with Factor Xa inhibitory activity

    Institute of Scientific and Technical Information of China (English)

    刘爱华; 朱元军; 刘晓岩; 王银叶

    2013-01-01

    Ancylostoma anticoagulant peptide 5 (AcAP5) is a strong inhibitor of human coagulation factor Xa (FXa).The N-terminal residues (N40) of AcAP5 contains a domain that could combine with FXa.In order to determine whether N40 protein has FXa inhibitory effect,we cloned,expressed and purified the protein for activity evaluation.The DNA fragment coding N40 was amplified by PCR,cloned into pET-30a to construct recombinant plasmid pET30a-N40,and subsequently transformed into E.coli.BL21 (DE3).Expression of N40 was induced by isopropyl β-D-l-thiogalactopyranoside (IPTG),and the interest protein was identified by SDS-PAGE and purified using one-step nickel (Ni) affinity chromatography.Under the optimal expression condition (0.05 mM IPTG for 6 h at 37 ℃),the purity of N40 reached 90%.We also evaluated the inhibition activity of N40 protein on FXa,finding the IC50 was 4.58× 10 5 mol/L.This study suggests the N40 of AcAP5 could combine with FXa to inhibit FXa activity.%犬钩虫抗凝肽5 (Ancylostoma anticoagulant peptide 5,AcAP5)N端40个氨基酸片段(N40)含有与FXa结合的结构域.为研究N40的FXa抑制作用,我们克隆、表达和纯化了N40,并检测其生物活性.用PCR扩增N40基因;将PCR产物克隆至原核表达载体pET-30a中,构建质粒pET30a-N40;将其转化入大肠杆菌E.coli.BL21 (DE3)中,IPTG诱导目的蛋白表达,SDS-PAGE电泳鉴定,经过镍柱亲和层析纯化,用BCA法进行蛋白定量,测定该蛋白抑制FXa的活性.限制性酶切鉴定和基因测序结果显示重组质粒构建成功;SDS-PAGE结果显示目的蛋白在E.coli.BL21(DE3)中为可溶性表达,亲和层析纯化后获得了纯度约90%的蛋白,经活性鉴定该蛋白确有抑制FXa的活性.

  19. Bien s’entourer pour mieux gouverner

    OpenAIRE

    Balouzat-Loubet, Christelle

    2011-01-01

    Le comté d’Artois revient à Mahaut, épouse du comte de Bourgogne Othon IV, en 1302. Veuve quelques mois plus tard, elle se retrouve seule à la tête de la principauté qu’elle gouverne à l’aide d’officiers toujours plus nombreux. Les baillis, le receveur, le trésorier et les autres officiers de l’Hôtel assurent le fonctionnement financier, judiciaire et domestique de la principauté artésienne. Plus proches de Mahaut, ses conseillers prennent une part active à la vie politique du comté. Le servi...

  20. Ciudad, bien y participación

    OpenAIRE

    Riva, F.

    2003-01-01

    The socio-political and metaphysical idea of participation seem to be distant and perhaps contrasting. But the ancient controversy about the names of the good (and the being) —univocal, equivocal, analogous— appears to be both metaphysical and political: having to deal with the multiplicity of the human, the question of unity and plurality of meanings cannot be dissociated from the discussion on the alternative models of human society (egalitarianism, individualism, participation).

  1. ADAM SMITH, UN LIBERALISMO BIEN TEMPERADO

    OpenAIRE

    Roland Pfefferkorn

    2008-01-01

    Gracias a la inmensa fortuna que ha conocido Enquiry into the Nature and Causes of the Wealth of Nations, Adam Smith es considerado como el "padre fundador" de la economía política clásica. Una lectura rápida de la obra ha permitido a veces hacer del célebre economista un pensador simplemente liberal, en una acepción parcial de la palabra. La Riqueza de las naciones merece una lectura cuidadosa. Aunque Smith es conocido principalmente como economista político, no hay que olvidar que fue titul...

  2. Chapitre 6. Le bien en pratique

    OpenAIRE

    Mol, Annemarie

    2013-01-01

    Ce dernier chapitre entremêle les différentes facettes de la logique du choix et de la logique du soin explorées au fil des chapitres précédents. Ce faisant, je me penche sur la question de l’activité morale pour revenir ensuite sur la notion d’“acteur”. Parvenir à articuler ce qui constitue le “patient actif” est en quelque sorte le couronnement de ce livre. En m’appuyant sur le cas du traitement et de la vie avec le diabète, j’ai fait ressortir une version singulière, spécifique et détaillé...

  3. El fondo documental audiovisual de Radiotelevisión Valenciana: Evolución, transformación y Bien de Interés Cultural. Patrimonio Audiovisual de la Comunidad Valenciana

    Directory of Open Access Journals (Sweden)

    Alfonso-Noguerón, Lola

    2014-07-01

    Full Text Available El Col·legi Oficial de Bibliotecaris i Documentalistes de la Comunitat Valenciana (COBDCV, junto a la Associació Ciudadana i Comunicació (ACICOM han solicitado recientemente la protección de Bien de Interés Cultural (BIC, para los fondos documentales y archivo de Radiotelevisió Valenciana SAU y Radiotelevisión Española de la Comunidad Valenciana. En este texto se analiza, la evolución y transformación de los materiales audiovisuales creados por las empresas del que fuera el Grupo de RTVV a lo largo de los veinticuatro años de emisión. Se mostrará cual ha sido la evolución de este archivo y la situación actual de los materiales, de las bases de datos y del sistema de gestión de contenidos multimedia. Se identifican las razones, como la obsolescencia de los materiales audiovisuales y la precaria situación económica del país, para evidenciar que pese a la protección legal, es un objetivo continuar con la transformación y digitalización del archivo y fondo audiovisual más importante de la Comunidad Valenciana.

  4. Sobre la promoción y la evaluación de la calidad de la educación superior como bien público y social

    Directory of Open Access Journals (Sweden)

    Rodrigo Arocena Linn

    2011-01-01

    Full Text Available Se considera la evaluación de la educación superior como bien público y social. Dado el creciente peso del conocimiento en las relaciones de poder, el ideal del Movimiento Latinoamericano de la Reforma Universitaria apunta a la centralidad de la democratización del conocimiento. Esta meta orienta el análisis de las tareas de las universidades públicas latinoamericanas en el contexto de la internacionalización de la educación superior. Generalizar el acceso a la educación avanzada y promover el éxito en los estudios aparecen como objetivos prioritarios. La noción de universidad para el desarrollo vertebral el enfoque. Esta noción se conecta con los procesos de innovación y las necesidades sociales, esbozando una estrategia para conectar la enseñanza, la investigación y la extensión con la inclusión social. Una (segunda Reforma Universitaria es necesaria para colaborar en el enfrentamiento a la desigualdad y al subdesarrollo. Impulsar esa colaboración debiera orientar la evaluación de las universidades.

  5. Bien-être émotionnel au travail et changement organisationnel Emotional Well-Being at Work and Organizational Change: The Essilor Case Bienestar emocional en el trabajo y cambio organizacional : el caso de Essilor

    Directory of Open Access Journals (Sweden)

    Catherine Remoussenard

    2013-05-01

    Full Text Available Aujourd’hui, la plupart des entreprises mettent en place des projets de changements organisationnels afin de s’adapter aux modifications d’un environnement très concurrentiel. Ce faisant, elles se heurtent à des difficultés liées notamment aux situations de mal-être que ces changements peuvent induire. Notre étude vise à explorer les effets de nouvelles politiques managériales sur le bien-être émotionnel des salariés. Plus précisément, nous explorons les politiques mises en œuvre par un des sites du Groupe Essilor dans le contexte d’un changement organisationnel. Nous analysons d’un point de vue quantitatif et qualitatif les effets induits par ces politiques sur les salariés et sur la façon dont Essilor-Dijon en tient compte dans sa gestion des collaborateurs pour améliorer le bien-être au travail. À la lumière de nos résultats, il apparaît que les émotions sont au cœur de la conduite du changement, pouvant jouer le rôle de freins ou de leviers en fonction des choix managériaux.Nowadays, companies are implementing organizational change in order to be able to adapt to an increasingly competitive environment. Because of this context, firms are often confronted with problems linked to stressful situations that they themselves have brought about. We explored the policies which were applied by one of the branches of the Essilor Group in an organizational change context. First, we quantitatively and qualitatively analyzed the effects which this policy has had on stress-related issues. Second, we looked at how Essilor-Dijon took into account these effects in managing its staff so as to improve their well-being at work. Our results show that emotions appear to be at the heart of managing change and can either be obstacles or facilitators, depending on the choices made by management.Hoy en día, la mayoría de las empresas están llevando a cabo proyectos de cambio organizacional con el objetivo de adaptarse a las

  6. El vivir bien, una propuesta de los pueblos indígenas a la discusión sobre el desarrollo (Living well, a proposal from indigenous people to the development discussion

    Directory of Open Access Journals (Sweden)

    Elisa Canqui Mollo

    2011-07-01

    Full Text Available ResumenÚltimamente hay una conciencia global sobre que la noción de desarrollo está pasando por serios procesos de crítica y reconstrucción, por las connotaciones evolucionistas y eurocéntricas predominantes en sus principales formulaciones, pensadas de cara a la construcción y ampliación de estados nacionales y de un proyecto económico y cultural dirigido a una progresiva modernización capitalista homogénea que busca la creciente satisfacción material e individual, fundada en formas que han amenazado con subordinar y transformar otros principios, culturas y conocimientos a su imagen y semejanza. Es en este marco, que el Vivir Bien, propuesta por los Pueblos Indígenas viene a sumarse a las distintas propuestas que han ido saliendo en cuanto a desarrollo se refiere. Esta propuesta comprendida por ellos como una traducción de las formas y estilos de vida, en su simplicidad muestra una compleja articulación entre la vida de los indígenas, sus recursos naturales y el vínculo estrecho entre ambos, dentro de un territorio.AbstractIn recent times there is a global awareness of the fact that the notion of development is going through a process of criticism and reconstruction, due to the evolutionary and Eurocentric connotations in its formulation, which is oriented to the construction and expansion of nation-states and an economic and cultural project led to a progressive and homogeneous capitalist modernization, aimed at increasing individual and material satisfaction. Those forms have threatened to subordinate and transform other principles, culture and knowledge. In this context we find the proposal of the indigenous peoples of Living Well. This proposal, understood by them as a translation of forms and lifestyles, shows in its simplicity, a complex articulation between the life of indigenous, their natural resources and the close link between them within a territory.

  7. Suma Qamaña, vivir bien, el Ethos de la nueva constitución boliviana (Suma Qamaña, Living Well, the Ethos of the new Bolivian constitution

    Directory of Open Access Journals (Sweden)

    Fernández, Hugo

    2009-12-01

    Full Text Available Resumen: Este artículo expone algunos antecedentes que explican por qué se ha introducido la expresión Vivir Bien (Suma Qamaña y sus variantes en el texto constitucional recientemente aprobado en Bolivia. Entre ellos menciona los sorprendentes resultados electorales obtenidos por Evo Morales, que se sustentan en la emergencia y consolidación del pensamiento indígena, en la clara voluntad de adquirir poder político por parte de las organizaciones indígenas y en la necesidad de cambiar el ordenamiento jurídico existente, empezando por la Constitución. Identifica igualmente algunos elementos que caracterizan la resistencia a estos esfuerzos en el ámbito de las tierras bajas. A la pregunta de por qué era necesario cambiar la Constitución, responde que la anterior pretendía la integración de los indígenas despojándoles de su identidad. Por el contrario, la actual se caracteriza por una marcada impronta indígena al tratar los principios, valores y fines del Estado. Es allí donde aparece la expresión Suma Qamaña y otras equivalentes en otras tantas lenguas indígenas, que es necesario leer como el Ethos que inspira a la nueva Constitución y que debe guiar en la construcción del nuevo Estado.Abstract: This article presents some background explaining why the term Living Well (Suma Qamaña and it variants has been introduced in the recently approved Constitution in Bolivia. This includes surprising election results obtained by Evo Morales, which are based on the emergence and consolidation of indigenous thought, the intention of acquiring political power by indigenous organizations and the need to change the existing legal order, starting by the Constitution. Some factors of the resistance to these efforts in the area of the lowlands are also identified. The previous Constitution wanted the integration of the indigenous identity. On the contrary, the current Constitution takes the indigenous thought to discuss the principles, values

  8. Efectos macroeconómicos de un aumento de la demanda de bienes y servicios de Tecnologías de la Información y Comunicación en España: la cuenta satélite de las Tecnologías de la Información y Comunicación 2005-2009

    OpenAIRE

    Juan Antonio Vicente Vírseda; Francisco Javier Parra Rodríguez; José Luis Zofío Prieto

    2012-01-01

    Partiendo de la cuenta satélite de las tecnologías de la información y la comunicación: CS-TIC 2005-2009, se presenta en este artículo un modelo de simulación basado en técnicas input-output, que permite calcular los efectos directos, indirectos e inducidos ligados al aumento de demanda final en bienes y servicios TIC, establecer los efectos macroeconómicos de la implantación de nuevas industrias TIC o de una sustitución de importaciones por producción interna de bienes TIC. Como novedad del ...

  9. Criaturas bien nacidas aunque mal habidas y bien habidas aunque mal nutridas.

    OpenAIRE

    Grajales, Agustín

    2008-01-01

    Sur la base de 12 396 actes de baptême des fils légitimes, naturels et abandonnés de la paroisse de El Sagrario de la cathédrale de la ville de Puebla au cours de la décennie qui va de 1783 a 1792, on analyse les taux d'ilégitimité par groupe éthnique (entre huit et vingt pour cent) ainsi que le phénomène de l'abandon d'enfants. Celui-ci est effectué au seuil des portes et dans une moindre mesure dans l'hôpital d'enfants abandonnés dont on mentionne son origine et couverture. L'étude aborde l...

  10. La vente des biens nationaux à la fin du XVIIIe siècle, nouvelle donne pour la ville The sale of national assets at the end of the 18th century – a gift to the city

    Directory of Open Access Journals (Sweden)

    François Antoine

    2009-05-01

    Full Text Available À la fin de l’Ancien Régime, les villes des Pays-Bas gardaient les traits de villes médiévales sans ordre et faites d’entrelacs de rues et de ruelles. Le caractère corporatif de la production limitait la présence de grands ensembles industriels et les couvents et leurs jardins occupaient une grande partie de la superficie intra et extra muros des cités. Par ailleurs, l’Église était propriétaire d’un important parc immobilier de petites demeures adossées à des églises jusqu’aux importants refuges d’abbayes dominant dans les campagnes de vastes espaces fonciers. Durant la deuxième moitié du xviiie, les autorités habsbourgeoises menèrent une politique tendant à moderniser les villes en faisant, en autres, tomber les enceintes et en donnant une nouvelle affectation aux couvents contemplatifs supprimés. La Révolution française bouleversa ces ensembles urbains en libérant d’un coup une masse très importante de biens immobiliers qui appartenait à l’Église et en modifiant radicalement les modes de production par la suppression des corporations de métiers. La bourgeoisie principalement négociante réussi habilement tirer tous les profits de cette nouvelle donne. Cet effet d’aubaine contribua grandement à faire passer nos régions dans un nouveau stade de leur démarrage industriel.At the end of the Ancien Régime, the towns of the Netherlands retained the characteristics of medieval towns, without any order and consisting of warrens of streets and alleys. The corporative nature of production limited the presence of major industrial complexes and the monasteries and convents, together with their gardens, covered a large part of the urban areas both within and outside city walls. In addition, the church had important property holdings, ranging from small residential properties attached to churches to major abbey residences dominating vast countryside estates. During the second half of the 18th century, the

  11. El emprendimiento y el bien común: ¿competencias complementarias o excluyentes? O empreendimento e o bem comum: competências excludentes ou complementarias? Entrepreneurship and the common good: complementary or exclusive aptitudes?

    Directory of Open Access Journals (Sweden)

    Juan David Enciso-Congote

    2010-04-01

    Full Text Available Este trabajo propone un análisis comparativo entre los requerimientos de la formación de competencias para el emprendimiento y para el desempeño laboral, de acuerdo con el escenario que sirve de contexto a cada una de ellas. En el caso del desempeño laboral, se toma como punto de referencia la estructura burocrática descrita por Max Weber. En cuanto al emprendimiento, las raíces son antropológicas, la naturaleza humana, independientemente de cualquier referente cultural o histórico. Estas consideraciones proporcionan un marco de referencia para reflexionar sobre las dificultades conceptuales y pedagógicas que obstaculizan la construcción de una visión más inclusiva de lo público y del compromiso que debe tener un profesional con la búsqueda del bien común y, por tanto, de la responsabilidad que recae en la formación universitaria para procurar este cometido.Este trabalho propõe uma análise comparativa entre os requisitos para a formação de competências para o empreendimento e o desempenho no trabalho, segundo o cenário que fornece o contexto para cada um deles. No caso do desempenho de trabalho, toma-se como ponto de referência a estrutura burocrática descrita por Max Weber. Respeito ao empreendimento, as raízes são antropológicas -da natureza humana-, independentemente de qualquer referência cultural ou histórica. Estas considerações fornecem um quadro para refletir sobre os desafios conceituais e pedagógicos que dificultam a construção de uma visão mais abrangente do bem público, do compromisso dos profissionais em procura do bem comum e, portanto, da responsabilidade que se encontra no ensino universitário para garantir esse papel.This study proposes a comparative analysis between the requirements involved in building aptitudes for entrepreneurship and those for job performance, according to the scenarios that serve as the context for each of them. In the case of job performance, the bureaucratic structure

  12. Se démarquer dans l’industrie du bien-être. Transnationalisme, innovation et indianité Standing out in the wellness industry. Transnationalism, innovation and indianness

    Directory of Open Access Journals (Sweden)

    Laurent Pordié

    2011-11-01

    Full Text Available L’industrie du bien-être se caractérise à la fois par un fort potentiel d’innovation dans le domaine thérapeutique et par une prétention à l’ancienneté de ces nouvelles thérapies. Cet article propose d’analyser ce paradoxe en étudiant les logiques à l’œuvre dans la construction d’une marque identifiant et distinguant Mango Spa, une chaîne indienne de centres de soins et de remise en forme. Il s’intéresse aux sens et aux implications de l’innovation thérapeutique dans le cas d’une firme qui revendique l’authenticité de ses traitements tout en puisant dans des ressources d’influences multiples afin de s’adapter à une clientèle cosmopolite. Ces services et ces produits fondent leur légitimité sur la tradition ayurvédique, mais ils doivent toutefois la défier afin d’acquérir leur propre visibilité. C’est ainsi que Mango Spa se démarque de ses concurrents. De nouvelles thérapies « indiennes » sont créées en mobilisant clients internationaux, thérapeutes de cultures disparates et industriels établis hors de l’Inde. La marque est produite au travers d’un faisceau complexe de relations transnationales. En examinant les forces globales et le caractère multidimensionnel de la production d’une marque indienne, cet article renseigne plus généralement sur la circulation et la transformation des idées, des objets et des pratiques.The wellness industry is characterized by both a high innovation potential in the therapeutic field and a claim to the antiquity of these new therapies. This article aims to analyze this paradox by studying the logic at work in the construction of a brand identifying and distinguishing Mango Spa, an Indian chain of health and fitness centers. Particularly interesting are the meanings and implications of therapeutic innovation in the case of a firm claiming the authenticity of its treatments while drawing on multiples resources and influences to adapt them to a

  13. The effect of artificial boundary grain on the magneto- and electro-transport properties of (1 − x)La0.7Ca0.3MnO3+xA (A=Al2O3 and Ag) nanocomposite

    International Nuclear Information System (INIS)

    The magneto- and electro-transport properties of two series of nanocrystalline (1−x)La0.7Ca0.3MnO3+xA (A: Al2O3 and Ag) composites have been systematically and thoroughly studied. The observed electronic transport behavior over the whole temperature range (5–300 K), especially the change in metal–insulator transition temperature with increasing Al2O3 and Ag content while the ferromagnetic–paramagnetic transition remained unaffected, was explained by applying a two-component phenomenological model. We have attributed the unusual low-temperature resistivity upturn of composites to a change in charging energy. Most interestingly, magneto-transport measurements showed that the low-field magnetoresistance (LFMR), as well as the high-field magnetoresistance (HFMR), displayed a Curie–Weiss-like law behavior. Basing on the spin-polarized transport of conduction electrons at the grain boundaries, we have analyzed our experimental data and found that the temperature dependence of low- and high-field magnetoresistance is controlled predominantly by the nature of the temperature response of surface magnetization of particles. The competition between grain-boundary pinning strength (k), magnetic field and thermal energy (kBT) created the temperature sensitive behavior of magnetoresistance as well as that of surface spin susceptibility (χ b)

  14. Diálogo Oriente-Occidente en la España de finales del siglo XIX. El primer teosofismo español (1888-1906) : un movimiento religioso heterodoxo bien integrado en los movimientos sociales de su época

    OpenAIRE

    Pomés i Vives, Jordi

    2006-01-01

    A finales del siglo XIX se dio en España un renacimiento orientalista impulsado por una importante élite de teosofistas, que por un lado emprendió una muy importante tarea de traducción (del inglés y francés al español) y divulgación de las principales obras teosóficas y orientalistas del momento y por otro supieron conectar muy bien con las corrientes ideológicas (como el librepensamiento), culturales (como el modernismo), científicas (como el naturismo) y hasta políticas (como el republican...

  15. Construcción y validación de una escala para la predisposición a compartir valores y principios de la Economía del Bien Común y la Educación Ambiental.

    OpenAIRE

    Tójar Hurtado, Juan Carlos; Velasco Martínez, Leticia C; Estrada Vidal, Ligia Isabel

    2015-01-01

    La economía del bien común (EBC) es más que una propuesta de modelo económico para superar la tradicional dicotomía entre capitalismo y comunismo. La EBC supone una apuesta por una serie de valores éticos concretos, alternativos a los que predominan en la economía global actual. Valores que están en la base de actitudes y comportamientos de los seres humanos y que pueden cambiar la manera en que nos relacionamos los unos con los otros y, por supuesto también, con el medio ambiente. La EBC ...

  16. El agua como bien común y público, desde el análisis de la acción colectiva del referendo por el agua / The water as a commons and public, from the analysis of collective action for water referendum

    OpenAIRE

    Gómez Bustos, Ivette Johanna

    2012-01-01

    El análisis de la dinámica de acción colectiva en torno a la consagración del agua como bien común y público en Colombia, durante el periodo 2006-2009, reconoce inicialmente antecedentes de movilización motivados por el acceso al agua, el servicio de alcantarillado y la reducción de tarifas, con formas de acción como paros, marchas, la defensa de acueductos comunitarios y acciones judiciales. Sin embargo al profundizar desde un enfoque cualitativo y explicativo en la defensa del agua, se encu...

  17. Good governance and tourism development in protected areas: The case of Phong Nha-Ke Bang National Park, central Vietnam

    OpenAIRE

    Anna Hübner; Lý T. Phong; Trương S.H. Châu

    2014-01-01

    Protected areas are increasingly expected to serve as a natural income-producing resource via the exploitation of recreational and touristic activities. Whilst tourism is often considered a viable option for generating income which benefits the conservation of a protected area, there are many cases in which insufficient and opaque planning hinder sustainable development, thereby reducing local benefit sharing and, ultimately, nature conservation. This article delineated and examined factors i...

  18. Xa因子抑制剂与华法林对房颤患者抗凝疗效的比较--Meta分析与系统性评价%Meta Analysis and System Review on Comparison of Factor Xa Inhibitors and Warfarin on the Anticoagulation Effect in Patient with Artrial Fibrillation

    Institute of Scientific and Technical Information of China (English)

    刘入源; 郭凤; 阿尔达克

    2015-01-01

    目的:系统性评价口服Xa抑制剂和华法林用于房颤患者抗凝治疗的有效性和安全性。方法按照Cochrane系统评价制作方法,计算机检索Pub Med数据库、Ovid数据库、EMBASE数据库、Medline光盘数据库、同方数据库检索相关文献,查找网络上有关的所有文章及未发表的病例对照实验,并用手工检索等方法收集相关文献,并对所有文献的参考文献进行进一步的检索。收集所有相关的病例对照试验,采用Cochrane协作网提供的RevMan5.0软件进行Meta分析,以获得口服Xa抑制剂和华法林相比对房颤患者抗凝效果的有效性和安全性的相关证据。结果 Xa抑制剂与华法林相比,能明显降低总死亡率【P=0.01,优势比(OR)0.89,95%可信区间(CI)(0.82,0.98)】、出血性脑卒中发生率【P<0.00001,优势(OR)0.49,95%可信区间(CI)(0.39,0.60)】、主要部位出血发生率【P=0.07,优势比(OR)0.76,95%可信区间(CI)(0.57,1.02)】;然而缺血性脑卒中发生率【P=0.18,优势比(OR)1.08,95%可信区间(CI)(0.97,1.20)】、心肌梗死发生率【P=0.19,优势比(OR)0.94,95%可信区间(CI)(0.82,1.08)】、消化道出血发生率【P=0.65,优势比(OR)1.07,95%可信区间(CI)(0.78,1.47)】无差别。结论新型口服抗凝剂利伐沙班、阿哌沙班、依度沙班的最大优势在于出血风险减少和用药方便,但目前此类药物临床使用时间过短和上市后可能昂贵的价格,同时缺乏明确的解救药物,尚不足以将这些药物作为一线用药考虑。%Objective To evaluation system of oral factor Xa inhibitor and warfarin for the effectiveness and safety of anticoagulation in patients with atrial fibrillation treatment. Methods the method of making Cochrane system in accordance with the evaluation, Pub Med database, Ovid database, EMBASE data base, Medline CD

  19. RIVAROXABAN: AN ORAL DIRECT INHIBITOR OF FACTOR X-A

    OpenAIRE

    Mehta Hiren R; Patel Paresh B; Galani Varsha J

    2011-01-01

    Venous thrombo embolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality in patients undergoing major orthopaedic surgery, and routine thrombo prophylaxis has been the standard of care over the last 20 years. Currently available options for the prevention of venous thrombo embolism in major orthopedic surgery include low-molecular-weight heparins, vitamin K antagonists and, more recently, the synthetic pentasaccharide fondaparinux....

  20. Características de los bovinos faenados en la Xa Región (Chile según las pautas indicadas en las normas oficiales de clasificación y tipificación Characteristics of cattle slaughtered within the Xth Region (Chile According to the terms stated by the official chilean standards for classification and carcass grading

    Directory of Open Access Journals (Sweden)

    C. GALLO

    1999-01-01

    Full Text Available Se describió el sexo y la edad de 114.666 bovinos faenados en los 22 mataderos habilitados en la Xa Región durante 1994 y las características de sus canales, utilizando las pautas impuestas por las normas chilenas oficiales de clasificación del ganado bovino y tipificación de sus canales. En cuanto a la clasificación de los bovinos, basada en la edad por cronometría dentaria (presencia de dientes de leche sin nivelar=DL , pinzas de leche niveladas=DL*, número de incisivos permanentes=2-8D, segundos medianos nivelados 8D* y el sexo, se encontró que la distribución regional de clases fue: 40.3% Novillito (DL* ó 2D; 16.1% Vaquilla (DL* ó 2D; 1.5% Torito (DL*; 10.6% Novillo (4-6D; 7.6% Vaca joven (4-6D; 9.0% Vaca adulta (8D; 6.1% Vaca vieja (8D*; 0.0% Toruno (2-8D*; 2.4% Toro (2-8D*; 4.2% Buey (8D ó 8D* y 2.2% Ternero/a (DL. Para las categorías de tipificación de las canales la distribución fue la siguiente: V=55.9%; A= 12.7%; C= 4,6%; U= 15.2%; N= 10.4% y O= 1.2%. Los diferentes grados de cobertura grasa se presentaron en un 10.1% el grado 0 (prácticamente no existe, un 78.3% el grado 1 (escasa, un 10.2% el grado 2 (abundante y un 1.4% el grado 3 (excesiva. Se registró un 7.7% de contusiones en el total de canales, de las cuales un 4.8% correspondió a contusiones de primer grado (afectan sólo tejido subcutáneo, un 2.1% de segundo grado (afectan también músculo y un 0.8% de tercer grado (afectan incluso hueso . Se concluye que en la Xa Región predomina la faena de bovinos jóvenes, de hasta 2 dientes incisivos permanentes, especialmente novillitos y vaquillas, cuyas canales presentan una cobertura grasa escasa, siendo categorizadas en V. Además, las contusiones que afectan la categorización (grado 2 y 3 se presentan en un bajo porcentajeThe present study describes the characteristics of 114.666 cattle slaughtered during 1994 in the 22 slaughterhouses functioning within the Xth Region and the corresponding carcasses produced

  1. Bien Préparer la prochaine quinquennale

    CERN Multimedia

    Staff Association

    2013-01-01

    2012 : une belle année pour la physique des particules Nous avons toutes et tous pu participer à la belle aventure de la physique des hautes énergies en 2012, la découverte, grâce au LHC d’une particule similaire au fameux boson de Higgs, pierre manquante à l’édifice du Modèle standard. Dans d’autres domaines, l’année 2012 a également été riche en performances exceptionnelles. Le Directeur général, son équipe et tous les Cernois peuvent être fiers de ces réalisations scientifiques et techniques extraordinaires. Les États membres ont montré leur soutien à l’Organisation en approuvant le budget 2013 et le plan à moyen terme jusqu’en 2017 pendant les Comités officiels de décembre 2012, malgré...

  2. L’idéologie : une notion bien embarrassante

    Directory of Open Access Journals (Sweden)

    Dominique Maingueneau

    2007-02-01

    Full Text Available Je ne pense pas être la personne la mieux placée pour réfléchir sur l’intérêt que présente la notion d’idéologie pour ceux qui étudient la littérature. Le travail conceptuel sur cette notion a plutôt été le fait de la génération antérieure à la mienne. Je suppose que si l’on m’a sollicité pour en parler, c’est parce que de l’intérieur de l’analyse du discours j’ai été amené à me confronter – quoique dans un cadre théorique et méthodologique très différent – à des questions du même ordre. Faut...

  3. La buena fe en la concurrencia sobre bienes inmuebles

    Directory of Open Access Journals (Sweden)

    Gastón Fernández Cruz

    1987-12-01

    Full Text Available El presente trabajo representa una apretada síntesis de la tesis titulada "El Papel de la buena fe en la transferencia de la Propiedad Inmueble". con la que el autor optó el grado de bachiller eb  Derecho en la Pontificia Universidad Católica del Perú en diciembre de 1984. Su pretensión no es otra que dejar claramente establecido el rol que representa la buena fe dentro de un sistema consensual de transferencia de la propiedad. cuando el derecho se enfrenta a una situación de excepción ante sucesivas transferencias.realizadas por un mismo sujeto.

  4. Les représentations du bien manger

    OpenAIRE

    Lahlou, Saadi

    1995-01-01

    This book contains a collection of articles on recent issues surrounding It is arranged around four major themes: consumers, institutions, competition and management. This chapter considers social representations of healthy eating. It contains the results of a survey conducted by CREDOC, amongst a sample of 2,000 French persons, aged over 18 which investiagted responses to questions surrounding what consititutes eating well. The survey was conductted in Spring 1990.

  5. Quand les anges deviennent de bien mauvais messagers

    OpenAIRE

    Latour, Bruno

    2007-01-01

    Ainsi, il y aurait des croyances des énoncés seraient échangés entre les hommes à propos d'objets - licornes, Saintes Vierges, ovnis - qui n'auraient pas de réalité ou dont les référentiels seraient incapables de présenter une valeur de vérité. D'où un grave problème : comment expliquer que nous échangions tellement de propos qui affectent de porter sur quelque chose d'objectif alors qu'ils n'informent réellement que sur l'état des sujets qui les tiennent ? Pour les philosophes du langage, le...

  6. Las bibliotecas como bien público: el factor humano

    OpenAIRE

    Pérez Iglesias, Javier

    1999-01-01

    This article discusses the benefits of the public library to the society. It exposes the necessity that libraries must offer quality and free public services. Public libraries are cultural institutions where the human factor is crucial.

  7. ENTRE EL HUMANISMO Y EL MERCANTILISMO: EL BIEN COMÚN EN EL ABASTO DE CARNE DE CIUDAD DE MÉXICO, 1708-1716 BETWEEN HUMANISM AND MERCANTILISM: THE COMMON GOOD IN THE MEAT SUPPLY OF THE CITY OF MEXICO, 1708-1716

    Directory of Open Access Journals (Sweden)

    Enriqueta Quiroz

    2011-12-01

    Full Text Available En este artículo se analizan las prácticas políticas ejercidas por miembros del gobierno local en la ciudad de México a principios del siglo XVIII, en torno al abasto de carne. La idea es observar la búsqueda del bien común, pero asentado no solo en bases humanistas, sino también dentro de una política mercantilista, en la que los intereses económicos de la Corona pretenden confluir como en un solo cuerpo con los de sus súbditos.This article analyzes the political practices exercised by local government officials in Mexico City in the early eighteenth century, around the meat supply. The idea is to observe the common good, but settled not only in humanism doctrine, but also within a mercantilist policy, in which the economic interests of the Crown intended to come together as one body with those of his subjects.

  8. Tradiciones políticas y memoria: significaciones sobre la noción de bien común en la experiencia de lucha ferroviaria Political traditions and memory: connotations of the notion of common property in the experience of the railway struggle

    Directory of Open Access Journals (Sweden)

    Mariano Salomone

    2012-07-01

    Full Text Available A mediados de 2007, tres organizaciones sociales en Mendoza comenzaron un proceso organizativo conjunto para defender como espacio público los terrenos de la ex Estación Central del Ferrocarril General San. Martín, actualmente abandonados tras su cierre. Frente a la aparición de nuevos proyectos de inversión privada, fundamentalmente inmobiliarios, estas organizaciones confluyeron en una lucha común bajo las consignas "No al uso privado de tierra pública" y "Planeamiento y gestión participativos sobre los destinos de estos terrenos". En este artículo procuro reconstruir la experiencia de uno de esos colectivos, el de ferroviarios. Se trata de indagar su punto de vista sobre dicho conflicto, rastreando en su experiencia y memoria histórica, las tradiciones y prácticas políticas que permitieron movilizar la construcción de ese espacio como bien común. El territorio se ha constituido en uno de los campos privilegiados de disputa. El proceso de espacialización de la lucha de clases implica la privatización paulatina de todo lo público y común, incluido el territorio. La noción de bienes comunes resulta imprescindible para pensar desde una perspectiva contrahegemónica. De ahí la importancia de interrogar la experiencia de los ferroviarios reconociendo, en su praxis, aquellos elementos que permiten realizar una lectura a contrapelo de la privatización y mercantilización como único proyecto de vida.In mid 2007 three social organizations in Mendoza started a common organizational process to defend the grounds of the former Central Station of the Ferrocarril Gral. San Martín (General San Martín railway as a public space, currently abandoned after its closure. Confronted with new projects of private investment, mainly related to Real Estate, these organizations united in common struggle under the slogans "No to the private use of public land" and "Participative planning and management for the use of these lands". In this article

  9. Receita pública e bem-estar social nos municípios mineiros emancipados no período de 1988 a 1997 Hacienda pública y bien estar social en los municipios de minas gerais emancipados en el periodo de 1988 a 1997 Revenue and social welfare in the emancipated municipalitiesof minas gerais during the periods of 1988 to 1997

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo da Costa Reis

    2013-04-01

    Full Text Available O movimento de descentralizações política, administrativa e fiscal intensificado a partir de 1988 tinha como objetivo promover a transferência de poder, recursos e atribuições para os governos locais. Além disso, esse fenômeno impulsionou o processo de emancipação municipal com o intuito de aproximar o poder público da sociedade, promovendo a melhoria da prestação de serviços. Este estudo apresenta a análise das receitas públicas e do bem-estar social dos municípios mineiros emancipados no período de 1988 a 1997. Para tanto, utilizaram-se testes de médias no intuito de comparar o desempenho dos municípios emancipados com o desempenho de seus municípios de origem. Como conclusão, verificou-se que os novos municípios são beneficiados com as transferências governamentais e possuem a mesma capacidade de arrecadação tributária dos seus municípios de origem. Não obstante, isso não permitiu que os citados municípios apresentassem nível de bem-estar superior em relação aos municípios de origem, assim como maior eficiência na gestão desses recursos, uma vez que estão mais próximos dos usuários.El proceso de descentralización política, administrativa y fiscal intensificado a partir de 1988 tenía como objetivo promover la transferencia de poder, recursos y atribuciones para los gobiernos locales. Además, ese proceso ha impulsado el proceso de emancipación municipal de prestación de servicios. Este estudio presenta el análisis de las haciendas públicas y del bien estar social de los municipios de Minas Gerais emancipados en el periodo de 1988 a 1997. Para tanto, se han utilizado testes de medias con el objetivo de comparar el desempeño de los municipios emancipados con el desempeño de sus municipios de origen. Como conclusión, se ha verificado que los nuevos municipios son beneficiados con las transferencias gubernamentales y poseen la misma capacidad de recaudación tributaria de sus municipios de origen

  10. Comprometimento, bem-estar e satisfação dos professores de administração de uma universidade federal Comprometimiento organizacional, bien estar y satisfacción en el trabajo de los profesores de administración de una universidad federal Commitment, well-being and satisfaction of management professors at a federal university

    Directory of Open Access Journals (Sweden)

    Maria Teodora Farias Traldi

    2012-08-01

    Full Text Available As pesquisas sobre o comprometimento organizacional, o bem-estar e a satisfação no trabalho vêm sendo realizadas com êxito na área de Psicologia Organizacional. Novos estudos sinalizam uma possível interdependência entre estes construtos. O objetivo precípuo desta pesquisa foi investigar as relações entre comprometimento organizacional, bem-estar e satisfação no trabalho, através de um censo realizado com os 104 professores de Administração de uma Universidade Federal, com taxa de resposta de 78%. Trata-se de uma pesquisa de campo, explicativa-descritiva, possuindo caráter transversal e natureza quantitativa. Os resultados mostraram que os professores apresentaram bons níveis de realização no trabalho e afetos positivos prevalentes em relação aos afetos negativos; declararam-se satisfeitos no trabalho quanto à chefia, aos colegas e à natureza do trabalho. O comprometimento organizacional normativo foi o único que contribuiu para a explicação da satisfação com o salário. O comprometimento organizacional calculativo contribuiu para a explicação dos fatores satisfação com a chefia e satisfação com as promoções. Finalmente, o comprometimento organizacional afetivo foi o principal preditor do bem-estar e da satisfação no trabalho. Este trabalho contribuiu tanto para a produção acadêmica das áreas de Psicologia e Comportamento Organizacional, quanto para a tomada de decisão quanto às políticas de gestão dos professores pesquisados, na perspectiva de que docentes e discentes possam desfrutar de um melhor ambiente de aprendizagem e produção do conhecimento.Las investigaciones sobre el comprometimiento organizacional, el bien estar y la satisfacción en el trabajo continúan a realizarse con éxito en el área de la Psicología Organizacional. Nuevos estudios señalan una posible interdependencia entre estos constructos. El objetivo mayor de esta investigación fue estudiar las relaciones entre

  11. « Il faut qu’un party se sente bien faible quand il accepte et qu’il recherche de tels appuis ». Femmes, jansénisme et publicité à Paris au xviiie siècle

    Directory of Open Access Journals (Sweden)

    Nicolas Lyon-Caen

    2009-07-01

    Full Text Available Le jansénisme devient, au siècle des Lumières, une déviance publique et donnée à voir à travers les lieux de la Ville. La présence féminine est évidente mais varie selon lessources car l’influence féminine n’est pas simplement tacite, mais constitue bel et bien un droit reconnu et sanctionné par des usages. Les institutions urbaines d’ancien régime sont cependant résolument masculines et l’impuissance des femmes réside plutôt dans leur extériorité au langage de celles-ci, sans que cela les empêche de faire « comme les hommes ». Mais leur investissement effectif dans la cause janséniste pose de manière récurrente, et insoluble, la question de leur rôle politique dans une société de plus en plus travaillée par le problème de la représentation.Contrary to the idea that associates religious deviance or minority with secrecy, Jansenism offers a different case study. During the eighteenth century Jansenists made their deviance public throughout the city of Paris, the major manifestation of which being the pilgrimage to the tomb of Deacon François de Pâris. Even though women participated to the movement, different sources give little evidence, as female influence was not simply tacit, but indeed constituted a right acknowledged by uses. Yet, urban institutions membership was resolutely male, the impotence of women, in that case, can be explained by their being foreign to the discourse of municipal bodies, which did not prevent them from acting “like men”. Therefore, the effective female investment in the Jansenist cause regularly posed the insoluble problem of their political role in a society in which the issue of representation became crucial.

  12. Tropical Forest Fire Susceptibility Mapping at the Cat Ba National Park Area, Hai Phong City, Vietnam, Using GIS-Based Kernel Logistic Regression

    Directory of Open Access Journals (Sweden)

    Dieu Tien Bui

    2016-04-01

    Full Text Available The Cat Ba National Park area (Vietnam with its tropical forest is recognized as being part of the world biodiversity conservation by the United Nations Educational, Scientific and Cultural Organization (UNESCO and is a well-known destination for tourists, with around 500,000 travelers per year. This area has been the site for many research projects; however, no project has been carried out for forest fire susceptibility assessment. Thus, protection of the forest including fire prevention is one of the main concerns of the local authorities. This work aims to produce a tropical forest fire susceptibility map for the Cat Ba National Park area, which may be helpful for the local authorities in forest fire protection management. To obtain this purpose, first, historical forest fires and related factors were collected from various sources to construct a GIS database. Then, a forest fire susceptibility model was developed using Kernel logistic regression. The quality of the model was assessed using the Receiver Operating Characteristic (ROC curve, area under the ROC curve (AUC, and five statistical evaluation measures. The usability of the resulting model is further compared with a benchmark model, the support vector machine (SVM. The results show that the Kernel logistic regression model has a high level of performance in both the training and validation dataset, with a prediction capability of 92.2%. Since the Kernel logistic regression model outperforms the benchmark model, we conclude that the proposed model is a promising alternative tool that should also be considered for forest fire susceptibility mapping in other areas. The results of this study are useful for the local authorities in forest planning and management.

  13. Leis, educação e sociedade: o bem comum na Alta Idade Média - doi: 10.4025/dialogos.v11i1e2.66 Leyes, educación y sociedad: el bien común durante La Alta Edad Media Laws, education and society: the common good in the High Middle Ages - doi: 10.4025/dialogos.v11i1e2.66

    Directory of Open Access Journals (Sweden)

    Terezinha Oliveira

    2010-05-01

    Full Text Available Neste artigo pretendemos analisar a estreita relação existente entre a elaboração de leis e a construção de uma sociedade voltada para o bem comum. Para analisarmos essa relação, reportamo-nos ao período histórico da Alta Idade Média. Procuramos mostrar que a identidade de uma sociedade também se constitui quando as leis são elaboradas, respeitadas e seguidas com eqüidade. Desse modo, por meio da História, podemos verificar de que maneira os indivíduos constroem suas relações de poder, governo e leis, elaborando seus laços sociais e suas características individuais e sociais. Em última instância, a História, ao nos permitir conhecernos a nós mesmos, possibilita que criemos o que acreditamos serem os interesses comuns, as leis gerais e o governo para o bem comum. O contrário, ou seja, o desconhecimento de nossas leis, de nossas identidades, implica tanto no desconhecimento das condições que criam o bem comum como, necessariamente, em sua destruição. É exatamente esse caminho que procuraremos apontar ao analisarmos alguns costumes e leis da Alta Idade Média.En este artículo pretendemos analizar la estrecha relación existente entre la elaboración de leyes y la construcción de una sociedad orientada hacia el bien común. Para analizar esta relación nos remitimos al período histórico de la Alta Edad Media. Pretendemos mostrar que la identidad de una sociedad también se constituye cuando las leyes son elaboradas, respetadas y seguidas con equidad. De este modo, podemos verificar a través de la Historia de qué manera los individuos construyen sus relaciones de poder, gobierno y leyes, elaborando sus lazos sociales y sus características individuales y sociales. En última instancia, al permitir conocernos a nosotros mismos, la Historia nos posibilita que inventemos lo que consideramos que son los intereses comunes, las leyes generales y el gobierno para el bien común. Lo contrario a esto, o sea, el

  14. De l’art de persuader à l’art de bien juger et de bien dire : la rhétorique chez Sperone Speroni

    OpenAIRE

    De Capitani, Patrizia

    2012-01-01

    Sperone Speroni (1500-1588) a choisi d’exprimer ses idées sur la littérature, la philosophie, les langues, l’amour, les femmes, parmi d’autres sujets, dans des dialogues dont il n’a pas donné d’édition définitive de son vivant. La première édition de ces dialogues, qui remonte à 1542, n’est pas elle-même de son fait, mais est due à son ami Daniele Barbaro qui la fit imprimer, sans doute avec l’accord de Speroni, à la suite d’un fâcheux épisode de plagiat qui impliqua Alessandro Piccolomini. L...

  15. Question 5. Analyse des méthodes usuelles de valorisation des biens environnementaux comme biens publics (services non-marchands)

    OpenAIRE

    Thomas, Alban; Gozlan, Estelle; Loope, Lloyd

    2014-01-01

    RésuméCet article a pour objet de présenter les méthodes et instruments à la disposition des décideurs publics afin de : 1) quantifier l’ensemble des coûts et des bénéfices environnementaux et socio-économiques liés aux risques d’envahissement du milieu néo-calédonien par des espèces allochtones et aux méthodes de contrôle envisagées, et 2) conduire une analyse coûts/bénéfices permettant d’évaluer l’opportunité de différentes formes d’intervention publique.La première étape d’une analyse coût...

  16. Bien común y beneficio particular: la incidencia de la planificación territorial en el valor de los bienes inmuebles

    Directory of Open Access Journals (Sweden)

    Ricardo Utz Barriga

    2015-04-01

    Full Text Available Hace 350 años, la población mundial no superaba los 500 millones de habitantes. Hace 25 años, esta población aumentó a 3.600 millones. En la actualidad, se superan los 5.000 millones de habitantes, lo que indica que la población del planeta duplica su cantidad sólo en algunas décadas.

  17. À la défense de mal-aimés souvent bien utiles : les guides de voyage. Propositions de lecture basées sur des guides de la Suisse de la fin du XVIIIe siècle et du XIXe siècle Defending the underdog: travel guidebooks. Suggestions based on guidebooks of Switzerland between the end of the XVIII century and the XIX century

    Directory of Open Access Journals (Sweden)

    Ariane Devanthéry

    2008-10-01

    Full Text Available Les intellectuels et la recherche universitaire entretiennent des rapports ambigus avec les guides de voyage. Pendant longtemps, ils ne s’en sont tout simplement pas occupés. Ce n’est que récemment que les historiens, géographes, sociologues ou ethnologues ont réalisé que ces écrits étaient des mines de renseignements tant historiques que géographiques ou sociaux, qui permettaient d’aborder sous un nouvel angle l’histoire et les transformations spatiales de certaines régions ainsi que des pratiques et des modes touristiques diverses. Une certaine reconnaissance a donc commencé à leur être accordée, bien qu’encore très partielle. Une grande part des spécialistes du littéraire peine encore toutefois à voir dans ces textes autre chose que de l’informatif-injonctif. Une lecture fonctionnelle, formelle et historique des guides de voyage, ainsi que des pratiques des lecteurs et voyageurs peut cependant révéler qu’ils sont plus riches que ce que l’on a longtemps cru. Nous proposons ici de renouveler notre regard sur ces objets.Academia has long taken an ambiguous stance on travel guidebooks. Indeed, It simply ignored them for the better part of their existence. Only recently have historians, geographers, sociologists or ethnologists, come to realize that travel guidebooks actually are mother lodes of historical, geographical, or social data, allowing to analyze from unexplored perspectives the history and spatial transformations of certain regions, as well as diverse tourist practices. Some level of incipient interest in those sources has therefore begun to emerge. However, most literary specialists still find it difficult to see in such documents anything more than information and prescriptions. A functional, formal, and historical reading of travel guidebooks, as well as of the practices of readers and travellers, can nonetheless reveal their long-overlooked richness. This contribution is an attempt at renewing our

  18. Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa

    OpenAIRE

    Panteleev Mikhail A; Lobanova Ekaterina S; Shibeko Alexey M; Ataullakhanov Fazoil I

    2010-01-01

    Abstract Background Blood coagulation is a complex network of biochemical reactions, which is peculiar in that it is time- and space-dependent, and has to function in the presence of rapid flow. Recent experimental reports suggest that flow plays a significant role in its regulation. The objective of this study was to use systems biology techniques to investigate this regulation and to identify mechanisms creating a flow-dependent switch in the coagulation onset. Results Using a detailed mech...

  19. AquaPathogen X--A template database for tracking field isolates of aquatic pathogens

    Science.gov (United States)

    Emmenegger, Evi; Kurath, Gael

    2012-01-01

    AquaPathogen X is a template database for recording information on individual isolates of aquatic pathogens and is available for download from the U.S. Geological Survey (USGS) Western Fisheries Research Center (WFRC) website (http://wfrc.usgs.gov). This template database can accommodate the nucleotide sequence data generated in molecular epidemiological studies along with the myriad of abiotic and biotic traits associated with isolates of various pathogens (for example, viruses, parasites, or bacteria) from multiple aquatic animal host species (for example, fish, shellfish, or shrimp). The simultaneous cataloging of isolates from different aquatic pathogens is a unique feature to the AquaPathogen X database, which can be used in surveillance of emerging aquatic animal diseases and clarification of main risk factors associated with pathogen incursions into new water systems. As a template database, the data fields are empty upon download and can be modified to user specifications. For example, an application of the template database that stores the epidemiological profiles of fish virus isolates, called Fish ViroTrak (fig. 1), was also developed (Emmenegger and others, 2011).

  20. Ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor Xa.

    OpenAIRE

    Cappello, M; Vlasuk, G P; Bergum, P W; Huang, S.; Hotez, P. J.

    1995-01-01

    Human hookworm infection is a major cause of gastrointestinal blood loss and iron deficiency anemia, affecting up to one billion people in the developing world. These soil-transmitted helminths cause blood loss during attachment to the intestinal mucosa by lacerating capillaries and ingesting extravasated blood. We have isolated the major anticoagulant used by adult worms to facilitate feeding and exacerbate intestinal blood loss. This 8.7-kDa peptide, named the Ancylostoma caninum anticoagul...

  1. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    OpenAIRE

    Alejandro Fernández Baptista; Cristina Seijo

    2014-01-01

    Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing com...

  2. PROTECCIÓN JURÍDICA DEL BIEN JURÍDICO DE

    OpenAIRE

    carreño garzón, luis ricardo

    2007-01-01

    La seguridad vial en Colombia es untema que actualmente ocupa un lugarprivilegiado en las discusiones jurídicasdentro de la academia y el CongresoNacional.El proyecto de ley que actualmente cursaen el Congreso de la República, ha sidoobjeto de debate y controversia, dado queal establecer penas de prisión para elconductor que sea sorprendido manejandoun vehículo bajo los efectos del alcohol osustancias psicoactivas, sin llegar si quieraa causar algún daño, estaría reviviendoun tipo de responsa...

  3. Planification territoriale: de nouveaux récits sur le bien commun?

    OpenAIRE

    Faure, Alain

    2011-01-01

    La planification territoriale est un objet d'études que les chercheurs en sciences politiques abordent plutôt de façon indirecte ces dernières années (via un projet, un dispositif, un conflit, une directive européenne...) alors que dans les années 80, une véritable tradition d'analyse s'était structurée pour étudier la mise en œuvre des politiques publiques sur le cas français. Il s'agissait à l'époque de décrypter l'affrontement des expertises professionnalisées dans les arènes du commissari...

  4. Le festival et le droit : essai sur la nature juridique d'un nouveau bien.

    OpenAIRE

    Emmanuel, Nathalie,

    2011-01-01

    A festival is a legal activity. This attractive entertaining event is regulated by the government as well through administrative policies measures as by its occupation of the public domain. This event, undoubtedly providing with potential assets for tourism and cultural policies of a given territory, has become an institution cofinanced by public authorities. Oscillating between public service mission and plain private service provision, the issue of local public interest of this activity is ...

  5. El Régimen Fiscal de los bienes de la Iglesia durante el siglo IV

    OpenAIRE

    Santos Yanguas, Narciso

    2011-01-01

    The patrimony of the Church, whose origins can be traced back to the Christian communities of the first three centuries, will not officially reckoned until Emperor Constantine’s times. Emperor Constantius II would then consolidate it by applying fiscal exemptions. Despite the fact that Emperor Julian’s rule (361-363) can in itself explain a degree of diminution, the truth is that the said patrimony was increased by the appropriation of pagan temples and the goods contained in them. In the ...

  6. Cumplimiento fiscal y bienes públicos: ¿Son realmente compatibles?

    OpenAIRE

    Sour, Laura

    2006-01-01

    This work provides experimental evidence of the determinants of tax compliance in Mexico, and compares them to the results of an experiment administered in the United States reported by Alm, Jackson and McKee (1992). The results for both countries are contrasted to the predictions of the Alligham-Sandmo model, whose basic assumption is that the probability of being detected cheating taxes is exogenous and independent of the level and type of income reported. Specifically, in both experiments,...

  7. Nous aimerions bien avoir une idée de génie

    CERN Multimedia

    Durrer, Ruth

    2005-01-01

    New observations and experiments show us today that cosmos is even more exotic than Einstein had envisaged. The authors, from Geneva University, explain how modern theoretical physics try to catch Universe (1½ page)

  8. De las cenizas a la Red: el Periodismo como bien común

    OpenAIRE

    José Carlos Sendín Gutiérrez

    2014-01-01

    Sampedro nos ofrece y comparte –porque el libro se puede leer en partes también en la red– no sólo y fundamentalmente un alegato a favor del periodismo, sino además, una defensa de un nuevo poder ciudadano y de una nueva democracia. Desde las primeras líneas el lector se siente sacudido por el alto voltaje de los datos, los personajes y el análisis perspicaz de la transformación social que parece apuntarse, pero que hasta ahora nadie había sabido traducir en palabras. Palabras que a veces par...

  9. La prescripción en los bienes inmateriales: las patentes

    OpenAIRE

    Vallejo Trujillo, Florencia; Trujillo de Misas, Claudia Lucía

    2013-01-01

    Este artículo presenta un estudio normativo, jurisprudencial y doctrinario, respecto a la posibilidad de adquirir por prescripción las patentes. Lo anterior, con el deseo de aportar al esclarecimiento de las consecuencias jurídicas que conlleva la declaración tardía de caducidad.

  10. Internet, salud y pacientes bien informados: una buena práctica al alcance de todos

    OpenAIRE

    Boté, Clara; Vall Casas, Aurora

    2012-01-01

    Actualmente los pacientes son cada vez más activos y autónomos, y están mejor informados por lo que se sienten comprometidos con su salud. Ello es debido a la importante presencia de las TIC, que favorecen el uso de Internet como fuente de información, y también a los cambios sociales y culturales que fomentan una nueva relación "profesional de la salud-paciente". Asimismo, la evolución de la sanidad centrada en el paciente conduce a una elección informada del usuario que quiere participar...

  11. Gains féminins, allocation des biens et statut nutritionnel des enfants au Burkina Faso

    OpenAIRE

    Jean-Pierre Lachaud

    1998-01-01

    The objective of the present study is to provide an econometric test to the relative validity of collective and unitary household behavior models, with the help of data of the 1994_95 Burkina Faso household survey. Obtained results seem to justify conclusions of noncooperative approach where the well_being of the group is partly function of the identity of the income earner, the African anthropological literature and what one observes commonly as for the functioning of households on this cont...

  12. La sécurité alimentaire : la construction d’un bien public global ?

    Directory of Open Access Journals (Sweden)

    Lerin François

    2012-09-01

    Full Text Available Soaring of food prices in 2007/08 has put again food security high in the global agenda. Several elements of explanation have been put forward to explain this crisis, including traditional ones such as imbalance supply/demand and stocks, energy effect, dollar effect ; and new factors such as biofuels, financial speculation and low interest rates, export bans. Various arguments linked to this food crisis have also questioned the global nature of food security issue : global insecurity (with the urban food riots, humanitarian (with the worsening situation of the bottom billion, cross-sectoral (with the relationships between agriculture and other related issues such as environment, health, trade rules and market impacts, etc.. Several initiatives have insisted on the need to address more seriously the problem at the global level. Indeed, lack of global coordination on food security has been recognized as a major problem. This lack of coordination could be understood both at the substantive level (i.e. between the different issue-areas which are part of the food security problem and at the institutional level (i.e. between the different international organizations in charge of food security leading to the fragmentation of global food security governance. This paper respectively analyses these two dimensions of fragmentation in order to assess the extent to which current global initiatives better address coordination needs for global food security.

  13. Movilidad de colecciones y exposicones temporales de bienes culturales. Una visión protocolaria.

    OpenAIRE

    Moltó Orts, Mª Teresa

    2016-01-01

    [EN] This Doctoral Thesis is based on the establishing of protocols and processes of action in order to carry out the movement of a collection for temporary exhibitions, evaluating the risks associated with handling all the time. The main line of research has been the study of documentation sources with reference to national, regional and European legislation patrimonial, on issues concerning the mobility of collections, as well as analyzing their compliance and implementation in the cont...

  14. Criteria for feasibility, health and welfare assessment of requirement to use second and subsequent generations of non-human primates or animals from self-sustaining colonies in research Critères d’évaluation de la faisabilité, de l’incidence sanitaire et des répercussions sur le bien-être animal, relatifs à l'obligation future d'utiliser des primates non humains issus uniquement des animaux de deuxième génération et plus ou des animaux provenant de colonies d'élevage auto-entretenues pour la recherche expérimentale

    Directory of Open Access Journals (Sweden)

    David Smith

    2011-10-01

    Full Text Available The European Directive 2010/63/EU on the protection of animals used for scientific purposes requires that a feasibility study must be conducted by the European Commission to determine if all sourcing of non-human primates from parents bred in captivity (F2 or from self-sustaining colonies can be achieved. This study should also include an assessment of animal health and welfare. Prior to the initiation of the European Commission’s study, it was considered by EFPIA and FELASA that the criteria to be used in the feasibility, health and welfare assessment should be established by experts to help expedite such a study. This paper identifies those criteria which may be useful in making policy decisions on the confirmation or reconsideration of the timetable for implementation of the F2 requirement. A key requirement before a number of criteria can be assessed is the generation of base-line data relating to the supply and future demand of non-human primates and the health and welfare status of current breeding colonies supplying the European market. Three groups of criteria have been indentified, namely feasibility, science and research and welfare. Within each group, a number of parameters are defined and their rationale for inclusion, together with suggested information points, is discussed.La directive européenne 2010/63/EU sur la protection des animaux utilisés à des fins scientifiques exige qu'une étude de faisabilité soit conduite par la Commission européenne afin de déterminer si l’approvisionnement en primates non-humains à partir de géniteurs élevés en captivité (F2 ou de colonies d'élevage autosuffisantes, peut être possible. Cette étude devra également inclure une évaluation de la santé des animaux et de leur bien-être. Avant le début de cette étude par la Commission européenne, l'EFPIA et FELASA ont estimé que les critères à utiliser pour les évaluations de la faisabilité, de la santé des animaux et du bien

  15. 'Quando la vittima è una comunità di fedeli. Tutela dei beni culturali ecclesiastici e difesa degli interessi legittimi della comunità nel segno della tradizione/Si la victime est une communauté de fidèles. Protection des biens culturels et ecclésiastiques et défense des intérêts légitimes de la communauté au nom de la tradition/When the Victim is a Community of Parishioners. Protection of Cultural Heritage of the Church and Defense of the Legitimate Interests of the Community in the Name of Tradition

    Directory of Open Access Journals (Sweden)

    Cicale Vito

    2011-12-01

    Full Text Available Il patrimonio culturale della Chiesa non può essere considerato come un insieme di oggetti da museo dato che il lorouso ha l’obiettivo di promuovere lo sviluppo dell’esperienza religiosa.La dimensione artistica del patrimonio culturale ecclesiastico è strettamente collegata alla sua qualità artistica e al suoruolo religioso. Perciò, il fine ultimo di tali opere d���arte è il servizio alla Chiesa, la facilitazione del contatto con Dio.Infatti, questo rapporto si riflette in tutte le opere che l’uomo ha associato all’adorazione di Dio: dai vasi sacri ai tessutifino alle costruzioni architettoniche monumentali. Questi beni contribuiscono a sostenere le tradizioni religiose che sonostate – e in una certa misura che sono ancora – la base di una rete sociale e di un’educazione alla cultura religiosa ecattolica.Le tradizioni religiose dei piccoli paesi rappresentano ancora l’elemento più gradito e diffuso della cultura popolare delnostro paese, il patrimonio certamente ancora oggi da promuovere e alimentare.RésuméLes biens culturels de l'Église ne peuvent pas être considérés comme des pièces de musée car leur usage a commeobjectif de développer l'expérience religieuse. La dimension artistique du patrimoine ecclésiastique est étroitement liéeà sa qualité artistique et à son rôle religieux. Par conséquent, le but ultime des oeuvres d’art est le service de l'Eglise, lafacilitation du contact avec Dieu.En effet, ce rapport se reflète dans toutes les oeuvres que l'homme a associées à l'adoration de Dieu : les vases sacrés, lestissus et les constructions les plus monumentales. Ces biens contribuent à soutenir les traditions religieuses qui ont été -et dans une certaine mesure sont encore - la base d'un réseau social et d’une éducation à la culture religieuse etcatholique. Les traditions religieuses des villages sont toujours les aspects le plus aimés de la culture populaire dansnotre pays, il s

  16. The discovery and exploration of Hang Son Doong

    Energy Technology Data Exchange (ETDEWEB)

    Limbert, H.; Limbert, D.; Hieu, N.; Phai, V. V.; Kinh Bac, D.; Phuong, T. H.; Granger, D.

    2016-08-01

    Hang Son Doong is located in the Phong Nha Ke Bang Limestone Massif in Quang Binh Province, Central Vietnam. Cave exploration by British cavers has been continuous in this area since 1990. Hang Son Doong is part of the Phong Nha Cave system which runs from the southern end of the National Park near the Lao border to the final resurgence at Phong Nha Cave. (Author)

  17. The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

    OpenAIRE

    Borensztajn, Keren; von der Thüsen, Jan H.; Peppelenbosch, Maikel P.; Spek, C Arnold

    2009-01-01

    Abstract Hepatic fibrosis is a common response to virtually all forms of chronic liver injury independent of the etiologic agent. Despite the relatively large population of patients suffering from hepatic fibrosis and cirrhosis, no efficient and well-tolerated drugs are available for the treatment of this disorder. The lack of efficient treatment options is at least partly because the underlying cellular mechanisms leading to hepatic fibrosis are only partly understood. It is thus of pivotal ...

  18. Fusion of CTA and XA data using 3D centerline registration for plaque visualization during coronary intervention

    Science.gov (United States)

    Kaila, Gaurav; Kitslaar, Pieter; Tu, Shengxian; Penicka, Martin; Dijkstra, Jouke; Lelieveldt, Boudewijn

    2016-03-01

    Coronary Artery Disease (CAD) results in the buildup of plaque below the intima layer inside the vessel wall of the coronary arteries causing narrowing of the vessel and obstructing blood flow. Percutaneous coronary intervention (PCI) is usually done to enlarge the vessel lumen and regain back normal flow of blood to the heart. During PCI, X-ray imaging is done to assist guide wire movement through the vessels to the area of stenosis. While X-ray imaging allows for good lumen visualization, information on plaque type is unavailable. Also due to the projection nature of the X-ray imaging, additional drawbacks such as foreshortening and overlap of vessels limit the efficacy of the cardiac intervention. Reconstruction of 3D vessel geometry from biplane X-ray acquisitions helps to overcome some of these projection drawbacks. However, the plaque type information remains an issue. In contrast, imaging using computed tomography angiography (CTA) can provide us with information on both lumen and plaque type and allows us to generate a complete 3D coronary vessel tree unaffected by the foreshortening and overlap problems of the X-ray imaging. In this paper, we combine x-ray biplane images with CT angiography to visualize three plaque types (dense calcium, fibrous fatty and necrotic core) on x-ray images. 3D registration using three different registration methods is done between coronary centerlines available from x-ray images and from the CTA volume along with 3D plaque information available from CTA. We compare the different registration methods and evaluate their performance based on 3D root mean squared errors. Two methods are used to project this 3D information onto 2D plane of the x-ray biplane images. Validation of our approach is performed using artificial biplane x-ray datasets.

  19. Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form.

    Science.gov (United States)

    Fujii, Yoshimine; Kanamaru, Taro; Kikuchi, Hiroshi; Nakagami, Hiroaki; Yamashita, Shinji; Akashi, Mitsuru; Sakuma, Shinji

    2011-12-15

    A clinical trial of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphtyl) propanoic acid (DX-9065) revealed that its oral bioavailability was only 3% when it was administered as a conventional capsule formulation. The low bioavailability of DX-9065 was likely caused by both its poor membrane permeability and its electrostatic interaction with anionic bile acids. We hypothesized that DX-9065 absorption would be enhanced when the cationic drug was free from the complex through its replacement with other cationic substances. Polystyrene nanospheres coated with cationic poly(vinylamine) and cholestyramine, which is clinically used as a cholesterol-lowering agent, dramatically prevented DX-9065 from interacting with chenodeoxycholic acid in vitro. Successive animal experiments showed that bioavailability of DX-9065 administered with these cationic substances was 2-3 times that of DX-9065 administered solely. A dry syrup formulation with one-half of a minimal cholesterol-lowering equivalent dose of cholestyramine was designed, and the clinical trial was resumed. A 1.3-fold increase in bioavailability of DX-9065 was observed when the dry syrup was administered. We successfully demonstrated that DX-9065 absorption was enhanced when the drug was administered with cationic additives; however, it appeared that the absorption-enhancing function of cholestyramine largely depended on its dose. The dose escalation is probably prerequisite for the significant improvement of DX-9065 absorption in humans. PMID:22001539

  20. Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino Acid Regions from Factor Va Heavy Chain†

    OpenAIRE

    Barhoover, Melissa A.; Orban, Tivadar; Bukys, Michael A.; Kalafatis, Michael

    2008-01-01

    The prothrombinase complex catalyzes the activation of prothrombin to α-thrombin. We have repetitively shown that amino acid region 695DYDY698 from the COOH terminus of the heavy chain of factor Va regulates the rate of cleavage of prothrombin at Arg271 by prothrombinase. We have also recently demonstrated that amino acid region 334DY335 is required for the optimal activity of prothrombinase. To assess the effect of these six amino acid residues on cofactor activity, we created recombinant fa...

  1. Estudio de heparinas y heparinoide de bajo peso molecular, pentasacárido y heparina no fraccionada en un modelo de trombosis "in vitro". Efecto sobre el depósito de plaquetas y la formación de fibrina

    OpenAIRE

    Lozano Molero, Miguel

    1992-01-01

    [spa] La heparina es una familia de cadenas de glicosaminoglicanos (GAGs) formados por residuos de glucosamina y ácido urónico, cuya eficacia y seguridad en la profilaxis y tratamiento de las enfermedades trombóticas están bien establecidas.El descubrimiento de que parecía posible desdoblar el efecto inhibidor del factor Xa de la inhibición de la trombina, con las fracciones de bajo peso molecular de la heparina despertó grandes expectativas y condujo a la introducción en terapéutica de las h...

  2. La información como bien económico: reflexiones sobre la crisis financiera de 2008

    OpenAIRE

    Cobarsí-Morales, Josep; Canals, Agustí; Ortoll, Eva

    2013-01-01

    Information is a key economic resource. Its proper conceptualization, as well as its practical integration in socioeconomic environment, poses several questions and follows general premises. These are reviewed, and once this framework is established it is illustrated with an informational analysis of the 2008 financial crisis, including remarks on changes in the financial system information environment that affected stakeholders’ information behaviour and decision making.

  3. Benefit corporations: desde la primacía del accionista hacia la del bien común

    OpenAIRE

    Roncancio-Rachid, R. A. (Rolando Andrés); Fontrodona, J. (Joan)

    2013-01-01

    This paper studies the Benefit corporations within the corporate law of the United States. We argue that this type of corporate form becomes a legal alternative to overcome the limitations of the paradigm of the primacy of the shareholder, and can find a good grounding in the common good approach of the firm. It shows how evolutionary processes of corporations in the United States and Continental Europe have as fundamental determinant legal attributes given to them by society through corporat...

  4. Le comportement des producteurs de biens addictifs légaux : implications d'une demande avec interactions sociales

    OpenAIRE

    Massin, Sophie

    2009-01-01

    URL des Documents de travail : http://ces.univ-paris1.fr/cesdp/CESFramDP2009.htmClassification JEL : D21, M14, M37, I28. Documents de travail du Centre d'Economie de la Sorbonne 2009.18 - ISSN : 1955-611X This article analyzes the behavior of a producer of a legal addictive good (tobacco, alcohol or gambling) facing a demand with social interactions, especially a deterrence effect of heavy use on initiation. We simulate an epidemic model to estimate at what conditions it could be intere...

  5. Terapias combinadas en la esquizofrenia, ¿Agregamos, mezclamos y confundimos, o bien, deconstruímos, y combinamos?.

    Directory of Open Access Journals (Sweden)

    Jorge Luis Tizón García

    2004-01-01

    Full Text Available Se realiza una reflexión sobre el estado actual de los programas terapéuticos o terapias que intentan combinar diversos tipos de terapias biológicas, psicológicas y psicosociales. Se ilustra el tema con viñetas clínicas de tratamientos de pacientes agorafóbicos y esquizofrénicos. La conclusión fundamental es que, hoy por hoy, con algunas excepciones, más que terapias combinadas se están practicando agregaciones de terapias o incluso mezclas más o menos confusas de terapias. Entre otros motivos, porque no se tienen en cuentan los criterios de calidad de una terapia, una consideración epistemológica más estricta de lo que debe ser una combinación de terapias, y la necesidad de de-construir las terapias previas y las combinadas y de investigar la eficacia, eficiencia, accesibilidad, etc de sus componentes. Con el fin de facilitar herramientas para la reflexión, se proponen una serie de tesis y principios para la organización de dichas terapias y se citan algunos intentos en tal sentido.

  6. "La política de reparto de bienes comunales en el municipio de San Juan Parangaricutiro (1861-1980)"

    OpenAIRE

    Saenz Gallegos, Catalina

    2012-01-01

    La historia de Michoacán no se concibe sin los movimientos sociales de la lucha por la tierra, en que las Comunidades indígenas no han sido ajenas, muestra de ello es que en la actualidad se sigan resistiendo a perder la posesión de sus territorios. Es por ello, que históricamente podemos entender que el Estado de Michoacán sea considerado por la Secretaría de la Reforma Agraria como uno de los focos Rojos del país, ya que el problema por la tierra ha sido un proceso hist...

  7. El control de los bienes: los libros de cuentas de los mercaderes Tarascó: 1329-1348

    OpenAIRE

    Varela-Rodríguez, M. Elisa

    1995-01-01

    El presente trabajo de investigación aúna el estudio de los aspectos económicos y sociales del comercio marítimo barcelonés, así como los aspectos paleográficos y codicológicos, con la finalidad de conseguir una mejor comprensión de la actividad comercial marítima y de los propios libros de cuentas como entidad y totalidad indisociable. Para ello se ha seguido una secuencia ordenada de lo general a lo particular: de los mercaderes y el comercio en el área de influencia catalano-aragonesa en l...

  8. La justicia y el bien común desde la perspectiva de J. Rawls, N. Bobbio y M. Villey

    OpenAIRE

    Andreu-Font, Esther

    2014-01-01

    Este trabajo analizará el concepto de justicia dentro de las filosofías de tres autores contemporáneos: Norberto Bobbio, para el que justicia equivale a legalidad e igualdad; John Rawls, que defiende que el consenso sea el origen de los principios de justicia, y Michel Villey, quien defiende una vuelta al derecho clásico y en quien encontramos numerosas referencias a la filosofía aristotélico-tomista. Las distintas nociones de la naturaleza humana determinarán en alto grado las diferentes con...

  9. La participation de l'enfant-acteur: réflexions sur son bien fondé

    OpenAIRE

    Jacquemet, Aline

    2012-01-01

    Le présent travail nous invite à nous interroger sur le droit à la participation, principe énoncé dans la Convention relative aux droits de l’enfant (ONU, 1989), lorsque l’enfant est un enfant artiste, acteur ou comédien. Ce travail propose un cheminement en deux temps. La première partie envisage de définir le terme d’acteur dans le monde des médias et de l’acteur tel que nous l’entendons en sociologie afin d’étudier l’idée de la participation des enfants acteurs. La seconde partie se propos...

  10. Trente ans après l'arbre des causes : ergonomie et bien-être au travai

    OpenAIRE

    Grosjean, Vincent

    2009-01-01

    International audience Ergonomics in France has recently begun to focus on psychosocial risks. This disciple tends to favor angles of approach different from the approaches typically found in the literature. The safety practice could benefit from this renewed approach. As far as the prevention of occupational risks is concerned, another approach of French origin has had a strong impact. This is the fault tree analysis, popularized by the french Institute for Research and Safety (INRS) sinc...

  11. Los efectos de la comunicación comercial sobre el Valor de Marca de bienes duraderos.

    OpenAIRE

    Villarejo Ramos, Ángel Francisco; Sánchez Franco, Manuel Jesús

    2004-01-01

    En el presente trabajo pretendemos establecer, a partir de una revisión teórica previa, una base empírica para la consideración de la influencia de la comunicación comercial como esfuerzo de marketing en la determinación del valor de marca del producto. Tras la revisión teórica que sustenta la aplicación de modelos de ecuaciones estructurales, planteamos la confirmación empírica de las relaciones existentes entre el esfuerzo en comunicación comercial...

  12. LA ELIMINACIÓN DE ORINA EN RESPUESTA A UNA INGESTA DE AGUA ES CONSISTENTE EN PERSONAS BIEN HIDRATADAS

    OpenAIRE

    Catalina Capitán-Jiménez; Luis Fernando Aragón-Vargas

    2010-01-01

    Recientemente se ha propuesto un método sencillo para evaluar el estado agudo de hidratación en humanos, pero persisten varias preguntas con respecto a su confiabilidad, validez y utilidad práctica. Objetivo: establecer la confiabilidad de un método simple para comprobar euhidratación, es decir, evaluar si este método puede ser usado como un indicador consistente del estado de hidratación de una persona. Además, se buscaba evaluar el efecto que tiene el ejercicio sobre la producción de orin...

  13. LA ELIMINACIÓN DE ORINA EN RESPUESTA A UNA INGESTA DE AGUA ES CONSISTENTE EN PERSONAS BIEN HIDRATADAS

    Directory of Open Access Journals (Sweden)

    Catalina Capitán-Jiménez

    2010-12-01

    Full Text Available Recientemente se ha propuesto un método sencillo para evaluar el estado agudo de hidratación en humanos, pero persisten varias preguntas con respecto a su confiabilidad, validez y utilidad práctica. Objetivo: establecer la confiabilidad de un método simple para comprobar euhidratación, es decir, evaluar si este método puede ser usado como un indicador consistente del estado de hidratación de una persona. Además, se buscaba evaluar el efecto que tiene el ejercicio sobre la producción de orina, cuando se mantiene el estado de euhidratación y se ingiere un volumen estandarizado de agua. Métodos: cinco hombres y cinco mujeres saludables y físicamente activos, con 22,5 ± 2,3 años (media ± desviación estándar, se presentaron al laboratorio después de un ayuno de 10 horas o más; en tres ocasiones, separadas por una semana de tiempo. En las dos condiciones idénticas de reposo (EuA y EuB, permanecieron sentados durante 45 minutos. En la condición de ejercicio (EuEjer realizaron ejercicio intermitentemente en una cámara de clima controlado (temperatura media y humedad relativa = 32 ± 3° C y 65 ± 7%, respectivamente por un lapso de 45 minutos, bebiendo agua para reponer las pérdidas por sudoración. El orden de los tratamientos fue aleatorio. Al terminar el tratamiento ingirieron un volumen de agua equivalente a 1,43% masa corporal (MC en 30 minutos, y se recogieron y midieron los volúmenes de orina eliminados posteriormente cada 30 minutos durante 3 horas. Resultados: El volumen de orina eliminado para la condición EuEjer (1205 ± 399.5 mL no fue diferente de EuB (1072.2±413.1 mL ni de EuA (1068 ± 382.87mL (p= 0.44; las dos condiciones de reposo fueron prácticamente idénticas (p = 0,98, y presentaron una correlación intraclase fuerte (r = 0.849, p = 0.001. Conclusiones: Este método, además de simple, demostró ser consistente en sus mediciones, por lo que puede ser utilizado con la certeza de que las mediciones son válidas y confiables.

  14. Évolution du bien-être des enfants et transformations de la famille américaine.

    OpenAIRE

    Gretchen A.condran; Franck F.furstenberg

    1994-01-01

    Condran (Gretchen A.), Furstenberg (Frank F.) . - Trends in child welfare and transformations in the American family Is there any detectable synchronism between trends in the number of working mothers and divorce rates or numbers of births out of wedlock and trends in the number of teenagers gaining secondary school qualifications or going into higher education, drug or alcohol consumption, committing suicide or murder and having children out of wedlock? The first factors are indicators of th...

  15. Crisis and Imagination. 11. bienální konference evropské asociace sociální antropologie

    Czech Academy of Sciences Publication Activity Database

    Uherek, Zdeněk

    2010-01-01

    Roč. 97, č. 4 (2010), s. 419-420. ISSN 0009-0794 Institutional research plan: CEZ:AV0Z90580513 Keywords : conference * social anthropology * Ireland Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.343, year: 2010

  16. LE DÉTOURNEMENT DE FONDS OU DE BIENS DES BUDGETS DE L’UNION EUROPÉENNE

    Directory of Open Access Journals (Sweden)

    Alexandru BOROI

    2007-09-01

    Full Text Available The embezzling of European communities funds is an important problem included in all criminal legislations from the European countries. This approach has been developed both trough the embezzling of the obtained funds, and also through the embezzling of a specific legal interest. As to the financial communitarian interests in the expenses domain changing the destination of the obtained funds means to use these previously legally obtained funds for other purposes than those originally meant. In Greece and Ireland this fraud of illegal redirection of funds is one of the potential expressions of fraudulent behavior that is provided in specific laws or specific provisions in the criminal code through frauds related to aids and incentives. In these countries changing the destination for funds that cannot be regarded as aids or incentives is not subjected to the provisions of the criminal law unless it has the elements of the breach of trust. In criminal codes from Austria, Denmark, Germany, Italy, Luxembourg, Spain and Sweden this fraudulent behavior related to the change of destination for funds is provided in specific stipulations different from those related to the fraud committed either by presenting false, inaccurate or incomplete documents or statements, or by avoiding to present information. The French criminal law stipulates this change of destination for funds as a crime related to the breach of trust. Unlike the other member states, none of the Great Britain jurisdictions stipulates a specific crime related to this fraud of changing the destination for funds. As for the communitarian financial interests related to incomes, frauds in the field of changing the destination for a legally obtained interest has to be followed by the unlawful assignment of some funds or the unlawful retaining of these funds. At the same time the resources of the European communities budgets are diminished. In Denmark, Greece, Spain, Ireland and Luxembourg changing the destination for a legally obtained interest is one of the potential types of fraudulent behavior provided in the criminal law in respect of the communitarian incomes.In Germany, Italy, France, Netherlands, Austria, Portugal and Finland tax fraud, regardless of the unique regulation in one or more specific laws, related to the customs regulations and the VAT, is defined in such a way as the fraudulent behavior is defined by any avoidance to indicate any change in the circumstances that can lead either to the illegally obtained funds, or to the unlawful retaining of these funds. This will result in the illegal decrease of the communitarian resources. In Romania the criminal provisions related to the embezzling of funds or interests are included in the art.18, par. 1,2, 3, Law no.78/2000. This fraud is directed at the social relations correlated with the financial discipline within the EU. Compliance with this discipline means to use the funds and the legally obtained interests in compliance with the legal provisions in force. This crime consists of affecting the money or the legally obtained interests by changing the destination for these funds. The crime of embezzling funds consists of changing the destination of the money, hence using it for other purposes than intended. Unlike the embezzlement of legally obtained interests, the crime of embezzling funds does not necessarily imply that the money is legally obtained.

  17. El idealismo de Fichte como “kantismo bien entendido”: dispersión, unidad y Yoidad

    OpenAIRE

    Gaudio, Mariano

    2015-01-01

    In the Second Introduction, Fichte constructs and explains his conception of idealism (the Science of Knowledge) in opposition with Kantianism, and more specifically with its dogmatism and empiricism. The criticism of dogmatism –where the I appears fragmented and dispersed in things–, is followed by that of Kantians that aimed to ground the I in the multiplicity of the given. This criticism leads to Fichte’s interpretation of Kantianism and to a new perspective on the unity and the Selfhood. ...

  18. Política pública de ordenamiento territorial en Colombia: conflicto interno y gobierno de los bienes comunes

    OpenAIRE

    Barreto García , Julián Camilo

    2013-01-01

    El conflicto interno colombiano es una realidad histórica y una variable que ha influido sobre el ordenamiento territorial; sin embargo, hasta el momento no ha sido tenida en cuenta como tal, lo que ha producido como consecuencia, que políticas transversales del orden nacional como la restitución de tierras, no hayan cumplido las expectativas. El objetivo de esta propuesta, obedece a establecer los alcances y limitaciones de una política pública de ordenamiento territorial en el contexto d...

  19. World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

    Science.gov (United States)

    Labay, Keith A.; Wilson, Frederic H.

    2004-01-01

    The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

  20. Jóvenes cristianos: ¿entre la polaridad del bien y del mal? El juego de la balanza

    Directory of Open Access Journals (Sweden)

    Betty Sánchez Sarmiento

    2000-10-01

    Full Text Available “Yo soy la herida y el cuchillo;¡Yo soy la bofetada y la mejilla¡¡Soy los elementos y la rueda, y la víctima y el verdugo”Baudelaire“I am the wound and the knife; I am the slap and the cheek; Iam the elements and the wheel, And the victim and the executioner.”Baudelaire

  1. Red docente de políticas inteligentes y Economía del Bien Común (III)

    OpenAIRE

    Ortiz García, Mercedes; Garay Montañez, Nilda; Gómez Calvo, Verónica; Romero-Tarín, Adela

    2016-01-01

    La Red docente ha servido para cuestionar y proponer la reformulación de la enseñanza y la investigación universitaria a partir de la máxima “ciencia sin conciencia, la ruina del alma”. Vivimos en la llamada la “sociedad del conocimiento”, pero España, como su entorno, se encuentra inmersa en una crisis económica: la balanza entre el desarrollo económico y social no está equilibrada. Hay algo más pues: una crisis de valores. De ahí que nuestra Red a través de sus distintas disciplinas (Derech...

  2. Futterqualität und Rekrutierungsverhalten bei einer stachellosen Biene, die einen Duftpfad legt (Scaptotrigona aff. depilis)

    OpenAIRE

    Schmidt, Veronika M; Zucchi, Ronaldo; Barth, Friedrich G

    2008-01-01

    Innerhalb der sozialen Insekten haben viele Gruppen die faszinierende Fähigkeit entwickelt, Nestgenossinnen zu rekrutieren. Rekrutierung beruht auf einer Kommunikation, die angewandt wird, um Mitglieder des Nestes zu einem bestimmten Ort zu bringen, wo Arbeit von Nöten ist (Wilson 1971). Daher beinhaltet die Rekrutierungskommunikation sowohl die Aktivierung von Nestgenossinnen innerhalb des Nestes, als auch die Orientierungshilfen für das Auffinden des Zielortes (Traniello & Robson 1995). Die...

  3. La Protección de bienes culturales en el Tribunal Penal Internacional para la ex Yugoslavia

    Directory of Open Access Journals (Sweden)

    Marina Lostal Becerril

    2012-01-01

    Full Text Available Since the outbreak of the Balkan war, three major events have taken place in what regards the protection of cultural property in armed conflict: the adoption of the Statute of the International Criminal Tribunal for the Former Yugoslavia which gives this court jurisdiction to try crimes against cultural and religious property; the approval of the Second Protocol to confirm and upgrade the obligations of the "1954 Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict"; and, finally, the "2003 UNESCO Declaration concerning the Intentional Destruction of Cultural Heritage" motivated by the destruction of the Buddhas of Bamiyan in 2001. While the latter two instruments have been exhaustively examined in scholarly literature, no updated study of the ICTY case-law exists yet. In this paper I go through all such cases and underline the following idea: the interpretation of ICTY has given rise to an involution and an evolution vis-à-vis the treaty law for the protection of cultural property in armed conflict; as well as to a doctrinal revolution by linking the destruction of cultural and religious property to the crimes of persecution and genocide. Since the interpretation of the ICTY largely diverges from the treatment afforded to cultural property in treaty law, I conclude that the protection of cultural property in armed conflict has by now a double life: one conventional and one jurisprudential

  4. Una propuesta metodológica para valoración de bienes inmuebles en aplicaciones catastrales (ING

    Directory of Open Access Journals (Sweden)

    Jorge Castro Fernández

    2016-03-01

    Full Text Available This paper reveals an analisis and proposes for the right application of technical norms for value or real states in municipal applications to comply with what it is established in the Law of property taxation N°7509 and their updates. In order, to do so, the technical norms are defined, their best ways and inconvenients, and it suggests how to improve them. It also suggest how to get value maps by square meter of terrain, their application and methodology for the best way to get them. An estimation of the work times with the suggested methodology, in order to reduce costs, increase performance and get the correct and effective way for making massive property valuation to achieve an increase of the municipal rate basis, is introduced. With the proposed methodology we pretend the Municipality to become effective in increasing the property taxing value, with the subsequent increasing of economic resources. The methodology takes into account some advantages that allow the Municipality to check the established value homogenous value zones for square meter of terrain. This, in order to have an internal control for construction permmission of urbanistic projects, and getting minimum rates by person and activities for the value processing.

  5. Los bosques templados del estado de Nuevo León: el manejo sustentable para bienes y servicios ambientales

    OpenAIRE

    José de Jesús Návar-Cháidez

    2010-01-01

    En este trabajo de investigación se presentan las características dasométricas, de existencias reales, diámetro, altura, densidad, distribuciones diamétricas, productividad, biomasa, carbono y diversidad biológica de los bosques templados del estado de Nuevo León, México. Esta información se derivó de 63 sitios muestreados en el marco del inventario nacional forestal de 2004-2006. De esta información se extrae que los bosques templados se encuentran en un estado juvenil, con distribuciones di...

  6. Leer bien para argumentar. Pedagogía para las competencias comunicativas escritas: lectura, escritura y argumentación

    OpenAIRE

    Figueredo-Bolívar, Sandra Milena; Herrera-González, José Alfredo

    2015-01-01

    Este artículo presenta el resultado de la investigación cualitativa que responde al problema: de qué manera las estrategias de formación lectoescritora aplicadas en el aula por los docentes de lengua castellana aportan a la producción de escritura argumentativa de los estudiantes de quinto, noveno y undécimo del Colegio El Rosario de Sogamoso. Para el diseño de los instrumentos, se conceptualiza la lectura como un proceso de interpretación en los niveles literal, inferencial y crítico; la esc...

  7. El Impuesto a la Transmisión Gratuita de Bienes y su reaparición en Argentina

    Directory of Open Access Journals (Sweden)

    Héctor W. Nazareno

    2009-12-01

    Full Text Available El presente trabajo tiene por objeto repasar aspectos principales de este gravamen, habida cuenta su reciente instrumentación legal por la Provincia de Buenos Aires, después de más de 30 años de haberse derogado el mismo en todos los fiscos del País

  8. ENFANTS PRIMO-ARRIVANTS OU ISSUS DE L'IMMIGRATION : DES ENJEUX D'INCLUSION DIFFERENTS MAIS BIEN REELS

    OpenAIRE

    Lorcerie, Françoise

    2011-01-01

    National audience The inclusive approach does not change the fundamentals of school democratization but it is pragmatic and pays attention to consequences. In other words, it regulates education on the basis of evidence, mainly from pupils whose marks or well-being are lower than expected. Newly arrived immigrants and secong generation children are two such categories. The paper shows their respective positions in education and concludes by focusing on the delicate use of social categories...

  9. BienDeAbajo : dos experiencias en la construcción de redes de información

    OpenAIRE

    Yulán, Sonia; Lencinas, Verónica

    2008-01-01

    Presentation of two experiences of construction of information systems directed to the virtual and real public, whose objectives aim to solve a concrete demand of accessibility to instruments, documents, cultural units of information and services. The Information system of the Center of Audio-visual Production is born from the demand of audio-visual producers of the interior of Argentina that required an organized, systematized source of intelligence and accessible. The REDBIPA (Virtual netwo...

  10. El consumo de bienes religiosos. Una introducción económica al caso español

    OpenAIRE

    Brañas-Garza, Pablo

    2003-01-01

    This paper uses the Economic of Religion issues to explore Spanish religious behaviour. Under this microeconomic framework religious practise is considered "rational" using Azzi-Ehrenberg (1975) arguments: salvation, social and professional motives. We test if that hypotheses may explain Spanish religious activity. To this end we run descriptive and multivariate analysis that allows us to conclude the following: theoretical models well perform Spanish data; gender, ageing, family size and edu...

  11. Trente ans après l'arbre des causes : ergonomie et bien-être au travai

    OpenAIRE

    Grosjean, Vincent

    2009-01-01

    L'ergonomie en France a commencé récemment à s'intéresser aux risques psychosociaux. Cette disciple tend à privilégier des angles d'approches quelques peu différents de ceux des démarches classiquement rencontrées dans la littérature. La prévention a sans doute à gagner à cette nouvelle approche. S'agissant de la prévention des risques professionnels, une autre démarche d'origine française à connu un fort retentissement. Il s'agit de l'arbre des causes, popularisé par l'INRS depuis les années...

  12. Bacterial Blight Resistance Genes Anchored to Physics Map of Rice Genome%水稻抗白叶枯病基因在物理图谱上的锚定

    Institute of Scientific and Technical Information of China (English)

    鲍思元

    2013-01-01

    到目前为止,经国际注册确认和期刊报道的水稻白叶枯病抗性基因共35个.已被定位的抗性基因有26个,即第1染色体上有2个,Xa29(t)和xa34(t);第3染色体上有Xa11;第4染色体上有6个,Xa1、Xa2、Xa12、Xa14、Xa25(t)、Xa31(t);第5染色体上有xa5;第6染色体上有3个,Xa7、Xa27(t)、xa33(t);第7染色体上有xa8;第8染色体上有xa13;第11染色体上有9个,Xa3/Xa26、Xa4、Xa1O、Xa21、Xa22(t)、Xa23、Xa30(t)、Xa32(t)、Xa36(t);第12染色体上有2个,xa25、xa32(t).Xa1、xa5、xa13、Xa21、Xa23、xa25、Xa26、Xa27已成功克隆.文中利用GRAMENE网站公布的抗白叶枯病基因的分子标记,在日本晴的测序图谱Gramene Annotated NipponbareSequence2009上进行物理图谱锚定,将已定位的26个抗白叶枯病基因锚定在其物理图谱的26个位点上,为抗白叶枯病基因的基因克隆、分子标记辅助选择奠定了基础.%Up to the present day, there are a total of 35 bacterial blight resistance genes registered internationally or reported in international journals. Among them, 26 genes were mapped, including Xa29(t) , xa34(t) on chromosome 1; Xall on chromosome 3; Xal, Xal, XaYl, Xal4, Xa25(t) , Xa31(t) on chromosome 4; xa5 on chromosome 5; Xal, Xall(t) , xa33(t) on chromosome 6; xd& on chromosome 7; xal3 on chromosome 8; Xa3/Xa26, XaA, XaW, Xa21 , Xa22(t) , Xa23, Xa30(t) , Xa32(t) , Xa36(t) on chromosome 11; xa25, xa32(t) on chromosome 12. 8 bacterial blight resistance genes were cloned, including Xal, xa5, xal3 , Xa21 , Xa23, xa25 , Xa26 and Xa21. Molecular markers of bacterial blight resistance genes from GRAMENE website were anchored to the physics map of Gramene Annotated Nipponbare Sequence 2009. 26 bacterial blight resistance genes were anchored to the physics map 26 units place through this research. The work laid the foundation for cloning bacterial blight resistance genes and the marker-assisted selection in breeding programs.

  13. The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin

    LENUS (Irish Health Repository)

    Solayar, Gandhi N

    2011-10-28

    Abstract Background Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban) is a new anti-thrombotic drug for the prevention of venous thromboembolism in adult patients undergoing elective hip and knee replacement surgery. The aim of this in vitro study was to investigate the possible effects of rivaroxaban on osteoblast viability, function and gene expression compared to enoxaparin, a commonly used LMWH. Methods Primary human osteoblast cultures were treated with varying concentrations of rivaroxaban (0.013, 0.13, 1.3 and 13 μg\\/ml) or enoxaparin (1, 10 and 100 μg\\/ml). The effect of each drug on osteoblast function was evaluated by measuring alkaline phosphatase activity. The MTS assay was used to assess the effect of drug treatments on cell proliferation. Changes in osteocalcin, Runx2 and BMP-2 messenger RNA (mRNA) expression following drug treatments were measured by real-time polymerase chain reaction (PCR). Results Rivaroxaban and enoxaparin treatment did not adversely affect osteoblast viability. However, both drugs caused a significant reduction in osteoblast function, as measured by alkaline phosphatase activity. This reduction in osteoblast function was associated with a reduction in the mRNA expression of the bone marker, osteocalcin, the transcription factor, Runx2, and the osteogenic factor, BMP-2. Conclusions These data show that rivaroxaban treatment may negatively affect bone through a reduction in osteoblast function.

  14. Do transgenesis and marker-assisted backcross breeding produce substantially equivalent plants? - A comparative study of transgenic and backcross rice carrying bacterial blight resistant gene Xa21

    OpenAIRE

    Gao, Lifen; Cao, Yinghao; Xia, Zhihui; Jiang, Guanghuai; Liu, Guozhen; Zhang, Weixiong; Zhai, Wenxue

    2013-01-01

    Background The potential impact of genetically modified (GM) plants on human health has attracted much attention worldwide, and the issue remains controversial. This is in sharp contrast to the broad acceptance of plants produced by breeding through Marker Assisted Backcrossing (MAB). Results Focusing on transcriptome variation and perturbation to signaling pathways, we assessed the molecular and biological aspects of substantial equivalence, a general principle for food safety endorsed by th...

  15. Transgenic expression of the rice Xa21 pattern recognition receptor in banana (Musa sp.) confers resistance to Xanthomonas campestris pv. musacearum

    OpenAIRE

    Tripathi, Jaindra Nath; Lorenzen, Jim; Bahar, Ofir; Ronald, Pamela; Tripathi, Leena

    2014-01-01

    Banana Xanthomonas wilt (BXW), caused by the bacterium Xanthomonas campestris pv. musacearum (Xcm), is the most devastating disease of banana in east and central Africa. The spread of BXW threatens the livelihood of millions of African farmers who depend on banana for food security and income. There are no commercial chemicals, bio-control agents or resistant cultivars available to control BXW. Here we take advantage of the robust resistance conferred by the rice pattern recognition receptor ...

  16. Nominal Group Technique consultation of a Pulmonary Rehabilitation Programme [v1; ref status: indexed, http://f1000r.es/2xa

    Directory of Open Access Journals (Sweden)

    Hayley A Hutchings

    2014-02-01

    Full Text Available Objective: The purpose of the study was to determine what patients, professionals and significant others regarded as the most important positive- and challenging aspects of Pulmonary Rehabilitation Programmes for patients with Chronic Obstructive Pulmonary Disease (COPD and to gain insight into how such programmes could be developed and improved. Method: A modified Nominal Group Technique method was used in three consultation workshops (one with COPD patients who had recently undertaken a Pulmonary Rehabilitation Programme; one with ‘significant others’ of the same patients; one with secondary care professionals who deliver the Pulmonary Rehabilitation Programme. Results: Each of three workshops resulted in the production of approximately ten positive- and ten challenging aspects related to Pulmonary Rehabilitation Programmes.  These were further developed by a process of thematisation into seven broad themes.  The most important was ‘the patient’, followed by ‘physical health’; jointly ranked as third were: ‘mental health’ and ‘knowledge and education’.  ‘The programme’ and ‘professional characteristics’ were jointly ranked as fifth, with ‘the future’ being ranked as the least important theme. Conclusions: The modified Nominal Group Technique method allowed the development of a ranked thematic list that illustrated the important positive- and challenging aspects of Pulmonary Rehabilitation Programmes for patients with COPD. These themes should be core to planning future Pulmonary Rehabilitation Programmes, particularly if patients and carer views are to be considered.

  17. Analysis of factorial moments of charged particle pseudorapidity distributions in C-(Ne, Cu) collisions at 4.5xA GeV/c

    International Nuclear Information System (INIS)

    Local fluctuation of charged particle pseudorapidity distribution in central C-(Ne,Cu) collisions at momentum 4,5 GeV/c per nucleon are investigated using the method of factorial moments. Manifestations of nonstational negative of the multiparticle fluctuations are obtained. Small contributions of the fluctuations of dynamical nature in the considered central collisions of nuclei are found in comparison to analogous investigations for all inelastic interactions

  18. The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin

    Directory of Open Access Journals (Sweden)

    Mulhall Kevin J

    2011-10-01

    Full Text Available Abstract Background Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs. A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban is a new anti-thrombotic drug for the prevention of venous thromboembolism in adult patients undergoing elective hip and knee replacement surgery. The aim of this in vitro study was to investigate the possible effects of rivaroxaban on osteoblast viability, function and gene expression compared to enoxaparin, a commonly used LMWH. Methods Primary human osteoblast cultures were treated with varying concentrations of rivaroxaban (0.013, 0.13, 1.3 and 13 μg/ml or enoxaparin (1, 10 and 100 μg/ml. The effect of each drug on osteoblast function was evaluated by measuring alkaline phosphatase activity. The MTS assay was used to assess the effect of drug treatments on cell proliferation. Changes in osteocalcin, Runx2 and BMP-2 messenger RNA (mRNA expression following drug treatments were measured by real-time polymerase chain reaction (PCR. Results Rivaroxaban and enoxaparin treatment did not adversely affect osteoblast viability. However, both drugs caused a significant reduction in osteoblast function, as measured by alkaline phosphatase activity. This reduction in osteoblast function was associated with a reduction in the mRNA expression of the bone marker, osteocalcin, the transcription factor, Runx2, and the osteogenic factor, BMP-2. Conclusions These data show that rivaroxaban treatment may negatively affect bone through a reduction in osteoblast function.

  19. Att växa upp i våldets närhet : ungdomars berättelser om våld i hemmet

    OpenAIRE

    Weinehall, Katarina

    1997-01-01

    In this dissertation, teenagers (13-19 years) are allowed to speak out. The purpose of the study was to gain knowledge regarding the conditions related to socialization in the proximity of violence through listening to, interpreting and attempting to understand the teenagers' narratives about life when violence is an everyday occurrence. Primarily, I wanted to obtain a picture of the conditions under which these girls and boys grew up as they themselves described them. My questions are primar...

  20. Contribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase†,‡

    OpenAIRE

    Hirbawi, Jamila; John L. Vaughn; Bukys, Michael A.; Vos, Hans L.; Kalafatis, Michael

    2010-01-01

    Factor Va, the cofactor of prothrombinase, is composed of heavy and light chains associated noncovalently in the presence of divalent metal ions. The COOH-terminal region of the heavy chain contains acidic amino acid clusters that are important for cofactor activity. In this work, we have investigated the role of amino acid region 659−663, which contains five consecutive acidic amino acid residues, by site-directed mutagenesis. We have generated factor V molecules in which all residues were m...

  1. QTL Information Table: 851 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available xa5 Resistance or Tolerance Bacterial blight resistance resistant or susceptible phenotype A)Phy ... complementation and further analyzing xa5 (Xa5) in comparison ... with its homolog TFIIAgamma1. Mol Genet Genomics 2 ...

  2. Oscillation : bioadéquation et bien-être sont-ils l'avenir d'un progrès durable pour nos enfants ?

    OpenAIRE

    Raffegeau, Franck; Tromeur, Eric

    2015-01-01

    Dans les décennies à venir, l'adaptation au changement climatique est une question vitale pour la perpétuation des espèces végétales et animales, dont l’espèce humaine. Alors vers quel type d'adaptation souhaitons-nous aller ? L’usage du mot « adaptation » est aujourd'hui confus. Les notions « d’adaptation », de dynamiques de développement des espèces, dont celle de l’humain et de leurs « relations de dépendances » semblent mal comprises par les leaders d’opinion, les décideurs publics et les...

  3. ¡Por tu propio bien! : El castigo corporal a niños y niñas en Chile

    OpenAIRE

    Rosa, Sandra

    2010-01-01

    En el 2007 se cambió el artículo 234 del Código Civil chileno, eliminando la autorización a los padres de usar toda forma de maltrato infantil. La pregunta de esta investigación es la siguiente ¿Cómo se pretende, tanto por parte del Estado como por parte de las organizaciones no gubernamentales chilenas, implementar la modificación de la ley chilena siguiendo la Convención Internacional sobre los Derechos del Niño (1989)? Esta pregunta pretendemos responderla con la ayuda de fuentes secundari...

  4. FACTORES DE ÉXITO EN PROVEEDORES DE BIENES MANUFACTURADOS DE LA SALMONICULTURA CHILENA SUCCESS FACTORS IN SUPPLIERS OF MANUFACTURES WITHIN THE CHILEAN SALMON INDUSTRY

    OpenAIRE

    Carlos Torres Fuchslocher; Hanns de la Fuente Mella

    2009-01-01

    Este artículo analiza, en base a un trabajo empírico, los principales factores a nivel de la empresa que han determinado el éxito de los proveedores locales de manufacturas, en términos de participación de mercado, en el cluster del salmón en Chile. La investigación envolvió un levantamiento de material empírico a través de 50 entrevistas, las cuales fueron evaluadas cualitativamente y por medio de un análisis econométrico de corte transversal, usando variables explicativas cualitativas. Los ...

  5. FACTORES DE ÉXITO EN PROVEEDORES DE BIENES MANUFACTURADOS DE LA SALMONICULTURA CHILENA SUCCESS FACTORS IN SUPPLIERS OF MANUFACTURES WITHIN THE CHILEAN SALMON INDUSTRY

    Directory of Open Access Journals (Sweden)

    Carlos Torres Fuchslocher

    2009-04-01

    Full Text Available Este artículo analiza, en base a un trabajo empírico, los principales factores a nivel de la empresa que han determinado el éxito de los proveedores locales de manufacturas, en términos de participación de mercado, en el cluster del salmón en Chile. La investigación envolvió un levantamiento de material empírico a través de 50 entrevistas, las cuales fueron evaluadas cualitativamente y por medio de un análisis econométrico de corte transversal, usando variables explicativas cualitativas. Los resultados destacan la especialización sectorial, la innovación en productos especializados para la industria y la cooperación horizontal, dentro de la estrategia de entrada; y la antigüedad de la empresa, la capacidad de innovación interna, la capacidad financiera (capacidad de otorgar crédito a clientes y bajo nivel de endeudamiento y la diversificación de la cartera productos, dentro de la competitividad previa, como determinantes del éxito de los proveedores.This article analyses the main factors at the firm-level which have determined the success, in terms of market share, of manufacture suppliers within the Chilean salmon industry. The analysis is based on data collected in an empirical research that included 50 interviews with suppliers. The data was evaluated through both a qualitative analysis and a cross section econometric analysis. The results show the importance of sectoral specialization, the innovation on specialized products for the aquaculture industry and horizontal cooperation within the entry strategy of firms, whereas the firm's age, the internal innovation capabilities, the own capital and the diversification of product portfolio were the main competitive factors before the entry.

  6. Bien recolectada pero mal tratada. El manejo municipal de la basura en Ciudad Obregón, Hermosillo y Nogales, Sonora

    OpenAIRE

    Nicolás Pineda Pablos; Edmundo Loera Burnes

    2007-01-01

    Este trabajo hace un acercamiento a la manera cómo los gobiernos municipales manejan la basura desde el punte de vista del enfoque denominado "gestión integral de los residuos sólidos". Para ello, primeramente se revisan el concepto y los tipos de basura, así como las características del modelo de gestión integral de la basura y algunas ideas sobre el papel de los "pepenadores". Posteriormente, se exponen los procesos de recolección y tratamiento de la basura, así como las actividades de reci...

  7. Bien recolectada pero mal tratada. El manejo municipal de la basura en Ciudad Obregón, Hermosillo y Nogales, Sonora

    Directory of Open Access Journals (Sweden)

    Nicolás Pineda Pablos

    2007-01-01

    Full Text Available Este trabajo hace un acercamiento a la manera cómo los gobiernos municipales manejan la basura desde el punte de vista del enfoque denominado "gestión integral de los residuos sólidos". Para ello, primeramente se revisan el concepto y los tipos de basura, así como las características del modelo de gestión integral de la basura y algunas ideas sobre el papel de los "pepenadores". Posteriormente, se exponen los procesos de recolección y tratamiento de la basura, así como las actividades de reciclaje y pepena que se llevan a cabo en Ciudad Obregón, Hermosillo y Nogales en el estado de Sonora (México. El estudio muestra que los servicios de estas ciudades están abocados principalmente a la etapa de la recolección y no contemplan ni la reducción ni el reciclaje. De las tres ciudades, sólo Hermosillo ha emprendido actividades parciales de reciclado y promoción de la reducción. En lo que se refiere al tratamiento, únicamente Hermosillo cuenta con un relleno sanitario que funciona adecuadamente, mientras que en Nogales el relleno sanitario con que se cuenta se maneja como tiradero y Ciudad Obregón carece enteramente de un sitio adecuado para el confinamiento de la basura. Por último, se revisa la situación del reciclado informal que hacen los pepenadores y se sugieren medidas a fin de formalizar su labor.

  8. LA VALORIZACIÓN DE LOS “BIENES COMUNITARIOS” EN LA RECONFIGURACIÓN GEOGRÁFICA DEL CAPITAL EN EL SURESTE MEXICANO

    Directory of Open Access Journals (Sweden)

    Diana Itzu Luna

    2011-12-01

    Full Text Available Normal 0 21 false false false ES-AR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} La extracción de recursos naturales, el control y uso de espacios estratégicos para ser valorizados como mercancías sigue siendo condición en la permanencia del sistema capitalista. En este artículo, se propone retomar categorías y discusiones de la teoría crítica de la economía política para indagar en un caso concreto las formas de desposesión, así como las estrategias de movimientos sociales ante la disputa socioterritorial del sureste mexicano. En el caso analizado, el estudio de las amenazas de desplazamientos forzados y el despojo de tierra de población indígena en resistencia nos lleva a poner sobre la mesa de discusión los mecanismos históricos de lo que Karl Marx llamó acumulación originaria. Hoy la Acumulación por Desposesión de David Harvey y el tema de “la renta de la vida” de Armando Bartra son cuestiones teóricas que sirven para indagar sobre lo político del Capital en la reconfiguración territorial. Siendo el despojo pasado presente requerimos conocer las formas de valorización de lo robado. Abordaré dos de los mecanismos en que se da la desposesión: Áreas de Protección Flora y Fauna y, el Programa de Reconversión productiva para incentivar las plantaciones de palma africana.

  9. Recettes pour la paix, les droits & le bien-être concoctées au sein de la Genève internationale

    CERN Document Server

    2015-01-01

    Cette diversité de recettes est une vitrine d’exemples du travail ainsi réalisé par les organisations basées à Genève, illustré sous une forme innovante, et incluant également des propositions de menus composés de trois plats élaborés par des Chefs cuisiniers exerçant dans des hôtels 5 étoiles sur la place de Genève.

  10. La inversión extranjera directa como una salida al problema de la brecha de bienes de capital y conocimientos en México

    OpenAIRE

    Lozano Cortés, René; Cabrera-Castellanos, Luis F.

    2007-01-01

    In this work we made an empirical application of the model of Romer (1993) for the 32 states of Mexico on period 1990-2000, in order to determine if this country faces a gap of physical goods or a technological gap in the ample sense (that is to say, that inlcluye knowledge and ideas). We found that in the indicated period, Mexico faces both gaps, and therefore, it can take advantage from the direct foreign Investment to cover both.

  11. El peligro moral de La Celestina. Análisis interdiscursivo jurídico-económico y literario de la circularidad de los bienes

    OpenAIRE

    Fernández-Jáuregui Rojas, C.

    2014-01-01

    The connection between elements of legal-economic and the literary work is proposed as to the case of La Celestina. An interdiscursive analysis is achieved in order to explain a legal-economic component which is necessary for the textual and literary constitution of this work. The chain of chance in La Celestina is a commercial chain built up upon a series of contracts that outcome with an ironic structure and purpose: the equalisation between the haste in living and the haste in dying ends u...

  12. Servicios, ética, derechos humanos, identidad y compromiso social : e-ciencia y la información como bien público, algunas propuestas

    OpenAIRE

    Pérez-González, Lourdes

    2011-01-01

    This paper will introduce some of the agents involved in context of protection (monopoly‐commoditization) / liberalization (open access as a public‐information) of information and their positions, citing the example of recent projects such as CODATA, Science Commons or, Open Data, focused to create tools for open access to scientific data, priority within the new information cyberinfrastructure and e‐science.

  13. ¿Desarrollo o bien vivir? Repensando la función social de la Universidad Intercultural desde el cuestionamiento al efecto educativo

    Directory of Open Access Journals (Sweden)

    Inés Olivera Rodríguez

    2015-01-01

    Full Text Available The educative institution is the result of a modern-colonial socialorder determined by a euro-centric knowledge that responds to the logic of capitalism as a world order of power. the debates about schooling that understands its function as the efficient insertion of individuals into society are proof of this. In the order of current public policies, the logic of human development still rules over the national educative projects. this problem worsens when one considers intercultural contexts once the logic of capital, productivity, and economic growth are not the base of other ways of seeing the world. Interculturality as a dialogue and interaction of different symbolic universes demands the incorporation of other epistemologies and schooling logics. Thus, mexican Intercultural universities demand new responses from the formal educative system. these proposals seem to approximate to the construction of plural societies, capable of including everybody in life projects. the purpose is the construction of a true dialogue between forms of knowledge. therefore, the main question that is asked here is: how can educative effects be thought in an intercultural context? to answer it, I have made a critical reading of Anibal Quijano’s theory of the coloniality of power which gives an understanding of interculturality based on the real inclusion of other epistemologies that allow seeing the world from other angles and other forms of knowledge.

  14. Etude comparative des coagulations du lait par actions de l'extrait des écorces de l'Ongokea gore et des enzymes coagulants bien connus

    Directory of Open Access Journals (Sweden)

    Libouga, DG.

    2008-01-01

    Full Text Available Milk Clotting Using Ongokea gore Bark Extract Compared to those Obtained to Well Known Milk Clotting Extracts. The evolution of firmness in curd obtained using plant extract (Ongokea gore barks and that using renounce coagulating enzymes (bovine pepsin, Endothia parasitica, porcine pepsin, Mucor pusillis, rennet were compared. The study was carried out using reconstituted milk (Berrigde substrate and a formagraph was used for the analysis of curd firmness. Variations in amplitude of the formagrammes were measured with time. It was noticed that at the same coagulation time, the curd firming rate of Ongokea gore extracts was higher than that of porcine pepsin but lower than those of Endothia parasitica, Mucor pusillis, bovine pepsin and rennet. The evolution of curd firmness with pH on one hand and the quantity of dissolved powder milk on the other hand showed some similarities in rennet and Ongokea gore extract curds: the effect of the pH of the milk substrate is less remarkable on the rate of curd firmness while this rate increases with the quantity of dissolved powder milk.

  15. Autogas at Equip'Auto 2001: a very calm vintage; Le GPL a Equip'Auto 2001, un cru bien calme

    Energy Technology Data Exchange (ETDEWEB)

    Valcano, N.

    2001-09-01

    Autogas equipment manufacturers and importers, as well as the other actors in this field will be present in a mitigated atmosphere at the Equip'Auto 2001 Trade Show, at Paris-Nord Villepinte from 16 to 21 October. The market is at slow pace after new regulatory changes and this leads importers and installers/fitters to act in a carefulness way, as the retrofit operation in progress across the country (the fitting of the R67-01 type safety relief valve) amounts today to a large share in installers' activity. Thus, no more than a dozen of booths will show autogas components and technologies. Nevertheless, some brand new products will be exhibited. At the end of August, foreign exhibitors listed were Sahinler Metal (Turkey) and Brecav (Italy). But some brands will be found on importers booths. Cora Auto distributes Tartarini's Etagas system, as does on its side 'la Carburation Gaz'. OMVL and now Landi will be found at France GPL Carburation's. Cofraca, the French arm of Necam-Koltec, will be present, as well as some installers groupings, dispensers manufacturers and Autogas distributors. (authors)

  16. Comer bien, comer mal: la medicalización del comportamiento alimentario Eating well, eating poorly and the medicalization of eating behavior

    Directory of Open Access Journals (Sweden)

    Mabel Gracia-Arnaiz

    2007-06-01

    Full Text Available En este artículo se analiza el progresivo proceso de medicalización del comportamiento alimentario por el cual una buena parte de los motivos pragmáticos o simbólicos que articulan la selección y el consumo humano de alimentos se ha sustituido por otros de orden nutricional. La normalización dietética se ha concretado, en particular en los contextos de relativa abundancia de alimentos, en torno de la dieta equilibrada, un patrón alimentario basado en la restricción y promoción del consumo de ciertos alimentos y nutrientes -qué y cuánto comer- y en la prescripción de un conjunto de pautas relativas a cómo, cuándo y con quién hacerlo, y cuyos objetivos han sido no sólo regular los cuidados del cuerpo y la salud, sino promover, a su vez, un cierto orden social y ético.This article describes how the progressive process of medicalization of food is inscribed within a biomedical logic that attempts to substitute many of the economic, adaptative and symbolic reasons that have ethnographically and historically conditioned eating habits in all cultures, exclusively for reasons of a dietetic nature. According to this logic, most of the population of modern societies does not know how to eat because they are victims of or have been made ill by the current profusion of food. They must, therefore, learn how to eat well, which in terms of eating practices means eating a little of everything, in moderation and in a balanced way. The main aim of current nutritional education is to (reestablish a supposed dietetic normality as far as food consumed, quantities, number of intakes and meal structures are concerned.

  17. Paula de Eguiluz y el arte del bien querer, apuntes para el estudio de la sensualidad y del cimarronaje femenino en el Caribe siglo XVII.

    Directory of Open Access Journals (Sweden)

    Adriana Maya.

    2002-07-01

    Full Text Available Paula de Eguiluz, like many other women of African ancestry born in the Caribbean, was obliged by the Inquisition to narrate her body, her emotions, her affections and her sexuality. Her testimonies manifest an untiring search for affection and reiterate the use of love magic so that others would be well loved. In the eyes of the inquisitors, women like Paula were “witches” and “sorcerers”. The declarations transcribed during the hearings that the Inquisition carried out against her shed light on two moments of her life. The first occurred in 1624 when she first appeared before the Tribunal of the Holy Office in the city of Cartagena de Indias. Paula was 33 years old and had recently been deported from Cuba. Accused of witchcraft, she was sentenced to wear a reconciliation habit, to 200 lashes, and to work in the city hospital. The second period developed 8 years later, in 1632, when the second process against her began. Paula was then 41 years old. During her eight years in Cartagena, she sold her knowledge of how to trap lovers and how to be well loved. Her clients were white women and free mulattas of the city who paid up to 50 pesos for her work. I wish to invite the reader to listen to Paula de Eguiluz say words that, although fragmented by the interpretation of the scribe, speak more of the condition of female slaves in the Caribbean in the 17th century than any of the stories of Sabbaths of witches that flew on broomsticks and devoured children that predominated in the minds of the judges. The fragments of her discourse will be interpreted from the perspective of the fugitive slaves, which means that knowledge of love and desire as well as the art of sensuality will become territories of freedom and autonomy for enslaved women.

  18. ¿Es el comercio exterior de bienes la solución para la crisis en España?

    OpenAIRE

    Sánchez Rodríguez, Ana Belén

    2014-01-01

    En estos últimos años la economía de nuestro país ha sufrido un gran revés debido al estallido de la burbuja inmobiliaria. Los precios de las viviendas llegaron a unos niveles muy altos, con muchos potenciales compradores que ven que no las podían pagar y, por tanto, cayó la demanda de viviendas. El estallido de la burbuja inmobiliaria nacional combinado con los efectos internacionales del estallido de la burbuja inmobiliaria estadounidense provoca que los bancos españoles dejen de obtener fi...

  19. „C’est trop bien, Marivaux“ – ‚La vie de Marianne‘ und ‚La vie d'Adèle‘ von Kechiche

    Directory of Open Access Journals (Sweden)

    Sabine Schrader

    2014-12-01

    Full Text Available Der Beitrag lenkt die Aufmerksamkeit auf die intermedialen Bezüge zwischen Kechiche und Marivaux und die jeweilige Inszenierung von Liebe. Dass die lesbische Liebe längst nicht so alltäglich ist, wie La vie d’Adèle sie erzählt, stellt die Rezeption des Films unter Beweis. Denn es ist vor allem die filmische Inszenierung des gleichgeschlechtlichen Begehrens, die die KritikerInnen beschäftigt. Aus diesem Grunde sei zum Abschluss ein kurzer Blick auf die umstrittene Darstellung sexueller Vielfalt in der zeitgenössischen französischen Gesellschaft geworfen.

  20. ¿Por qué existe el Estado y no más bien la anarquía? (El anarco-comunitarismo de Michael Taylor

    Directory of Open Access Journals (Sweden)

    Rivera, Juan Antonio

    1996-04-01

    Full Text Available Not available.

    Se expone la perspectiva anarco-comunitarísta de Michael Taylor, y se la distingue de la anarco-capitalista de autores como Murray Rothbard, David Friedman o, en menor medida, Robert Nozick. El anarco- comunitarismo de Taylor está sólidamente asentado en la teoría de juegos; concretamente, en los análisis dinámicos del Dilema del Prisionero. Sobre la base de estos análisis, a los que el propio autor ha hecho contribuciones sustanciales, se pone de relieve la inviabilidad práctica de una anarquía perfecta, sin controles sociales externos. Pero Taylor muestra que hay, con todo, lugar para un orden social sostenido en controles informales y ampliamente descentralizados, es decir, fundado en vínculos comunitarios, y que ésta ha sido la solución al problema del orden social durante la mayor parte de la historia de la especie. Se discuten luego las circunstancias que presumiblemente dieron lugar a la crisis y obsolescencia de la solución anarco-comunitarista y su sustitución por la respuesta institucional basada en la presencia del Estado. Se concluye el escrito ensalzando los méritos teóricos de Taylor pero poniendo en duda la validez de los presupuestos valorativos que animan sus modestas proposiciones de cambio social.

  1. ¿A QUIÉN PERTENECE LA CULTURA? REFLEXIONES SOBRE UN BIEN COMÚN EN LA ECONOMÍA DEL CONOCIMIENTO

    OpenAIRE

    Molina Roldán, Ahtziri

    2013-01-01

    A lo largo de la historia, se han dado múltiples definiciones de lo que es cultura, las cuales están de acuerdo con las corrientes teóricas, el momento histórico en que aparecen y su lugar de origen. Por ello se han desarrollado tantas posturas teóricas ( hablar de) como marcos para la acción (hablar para) desde distintos podios de observación. Considero que en el contexto actual de globalización, donde el mercado es el principal móvil, es preciso inquirir sobre el valor de cambio que esta ca...

  2. El género en el corazón de la crisis: hacia los cuidados como bien común

    OpenAIRE

    Ezquerra, Sandra

    2014-01-01

    La presente comunicación parte de la premisa que la actual crisis económica en el Estado español, así como su gestión política, se ven configuradas por el género, adoptando para ello como eje analítico el concepto de acumulación por desposesión. El aumento de la carga total de trabajo de las mujeres, así como la intensificación de sus responsabilidades reproductivas responden a una estrategia político-económica de privatización y re-hogarización de la reproducción en aras de...

  3. Les biens immatériels saisis par le droit des sûretés réelles mobilières conventionnelles

    OpenAIRE

    Pinto Hania, Vanessa

    2011-01-01

    Immaterial assets are traditionally described either as intangible assets or as intangible or intellectual property, or else as operating assets, but most of those terms are not satisfactory. This class of assets actually suffers from a lack of definition. However, some people state that they represent a form of economic wealth, a fantastic source of credit for the debtors, and a guarantee of safety for the creditors. And yet, French legislation seems to have ignored immaterial assets.This is...

  4. El Puerto de La Laja (Huelva, como Bien de Interés Cultural en la categoría de Sitio Histórico

    Directory of Open Access Journals (Sweden)

    Emilio Romero Macías

    2010-01-01

    de sol y playa para el conocimiento de otras culturas y como plan dinamizador de zonas que han sido afectadas por el declive de la minería en nuestra provincia. Parte del poblado del Puerto de La Laja se encuentra actualmente rehabilitado para su explotación como turismo rural, por lo que la arquitectura en cierto modo ha tratado de conjuntar la antigua disposición de las casas con las mejoras realizadas para este tipo de uso.

  5. ¿Desarrollo o bien vivir?: rethinking the social role of the Intercultural University from the questioning of the Educational Effect

    Directory of Open Access Journals (Sweden)

    Inés OliveraRodríguez

    2014-01-01

    Full Text Available La institución educativa es el resultado de un orden social moderno-colonial, determinado por un saber eurocéntrico que responde a la lógica del capitalismo como orden mundial de poder. Prueba de esto son los debates en torno a la escolaridad que comprenden su función social desde la inserción eficiente de los sujetos en la sociedad. En el orden de las políticas públicas vigentes, la lógica del desarrollo humano es lo que sigue primando en los proyectos educativos nacionales. Esta problemática se agrava cuando se piensa en los contextos interculturales una vez que la lógica del capital, de la productividad y el crecimiento económico, no son parte de otras formas de ver el mundo. La interculturalidad como diálogo e interacción de universos simbólicos distintos exige la incorporación de otras epistemologías y lógicas escolares. Lo intercultural, desde las universidades Interculturales mexicanas, exige nuevas respuestas del sistema educativo formal; siendo que estas propuestas parecen aproximarse a la construcción de sociedades plurales capaces de incluir a todos y todas en los proyectos de vida. Considerando esto, la pregunta central para la reflexión que aquí se propone es: ¿cómo se puede pensar los efectos educativos en un contexto intercultural? Para esto hemos asumido la lectura crítica desde la teoría de la colonialidad del poder de Aníbal Quijano, para pensar la interculturalidad desde la inclusión verdadera de otras epistemologías que permitan pensar el mundo desde otros lugares y desde otros saberes.

  6. Inteligencia emocional en las entidades de información ¿Cómo encauzar los afectos en bien de la organización?

    OpenAIRE

    Núñez Paula, Israel Adrián

    2002-01-01

    Emotional intelligence is used as term for the complex capacity integrated by a system of attitudes and abilities (for exemple perception of control, to contact with other people, etc.) and the individual conduct, mental reactions, states, kinds of communication, etc. These factors affect the success, as well as the personal and social satisfaction of the employees in an organization.

  7. Prospective pour l'énergie fossile : les limites physiques sur l'offre sont-elles bien anticipées ?

    OpenAIRE

    WINGERT, JL; HIVERT, L

    2010-01-01

    La volonté de limiter l'usage de produits pétroliers et plus généralement de sources d'énergie contenant du carbone (pétrole, gaz et charbon) existe notamment pour des raisons économiques et environnementales (émissions de gaz à effets de serre). Si les pays anciennement industrialisés, notamment européens, stabilisent ou réduisent leur production de produits pétroliers, il n'en reste pas moins que la demande garde une certaine vigueur au niveau mondial malgré la crise économique à cause des ...

  8. Katimavik Participant's Manual, Book VIII, Nutrition and Well-Being = Katimavik manuel du participant, cahier VIII, l'alimentation et le bien-etre.

    Science.gov (United States)

    Crelinsten, Michael, Ed.

    The bilingual student manual focuses on the nutrition and well-being learning activity portion of Katimavik, a nine-month volunteer community service and experiential learning program for 17 to 21 year old Canadians. Providing participants with basic information and tools to assess and improve nutritional states and tie nutrition concerns into a…

  9. El territorio, un bien que conviene ordenar: las salinas del litoral e interior de la Región de Murcia

    Directory of Open Access Journals (Sweden)

    Salvador Gil Guirado

    2010-01-01

    Full Text Available En regiones como Murcia, ha existido un gran interés por acondicionar y ordenar ciertos espacios para la obtención de la sal. Esta ordenación del territorio, ha creado unos paisajes propios: las salinas, distinguiendo entre las litorales y las de interior. La metodología de trabajo, nos ha permitido localizar, describir y explicar casi una treintena de salinas en toda la Región de Murcia. Algunas continúan funcionando desde época romana como las del Principal en Jumilla, otras junto a la explotación salinera también son humedales protegidos legalmente (San Pedro del Pinatar en el litoral y Cabezo de la Rosa y Rambla Salada en el interior, pero la mayor parte están en proceso de abandono. Por lo que urge planificar para poner en valor este rico patrimonio de la Cultura del Agua y la Sal, generando así una gestión sostenible de los paisajes salineros.

  10. Le bien-être spirituel auprès de personnes atteintes d'un cancer avancé en situation de soins à domicile: travail de Bachelor

    OpenAIRE

    Ben-Othman, Yasmina; Blanc, Lauriane; Kabashi, Robertina; Nydegger, Marion; Rodriguez da Rocha, Gora

    2015-01-01

    Dans le cadre de notre travail de Bachelor en Sciences Infirmiers, nous avons effectué une revue de la littérature. L’objectif est d’explorer l’influence de la spiritualité sur l’acceptation de la mort auprès des personnes atteintes d’un cancer avancé en soins palliatifs. En effet, le cancer est la deuxième cause de mortalité dans le monde après les maladies cardiovasculaires. Il nous a semblé pertinent de retracer les besoins des patients en fin de vie et les stratégies mises en œuvre par le...

  11. Les directives anticipées des personnes atteintes d’une démence de type Alzheimer : Comment faire pour bien faire?

    Directory of Open Access Journals (Sweden)

    Perreault, Line

    2016-01-01

    Full Text Available The Law on End of Life Care is now effective in Quebec. This law provides for a system of advanced medical directives. Respecting advanced directives (AD issued in anticipation of incapacity can be a beneficial ethical way to ensure self-determination of the patient in a context where a person’s incapacity is total and of short duration (e.g., terminal cancer. But what about when the loss of decision- making abilities is gradual and spread over a long period of time, as is the case of people with Alzheimer’s type dementia (ATD? Although the cognitive decline associated with ATD legitimizes the use of AD to promote self- determination of these people, relying solely on a person’s wishes expressed verbally or in writing to their relatives or physician to guide care is an approach that can be ethically risky. A review of the literature on AD, a study of the clinical features associated with ATD, and a critical analysis of a fictitious clinical case will help demonstrate the need for developing a gradual approach to revalidate agreements that take into consideration the AD of the person with a ATD while weighing their wishes and views in real time, their current quality of life and that of their caregiver. The beneficial deployment of AD relies on the ability of the actors involved to consider this as a process of revalidation of agreements. This necessary paradigm shift will ensure that actualising the self-determination of people with ATD does not come at the expense of their dignity, safety and integrity. Such an approach remains to be developed and promoted for people with ATD in Quebec. Health policies that move in this direction, as well as specific normative benchmarks for this clientele, are needed rapidly in the current Quebec context, which is joining the development of a system of “advanced medical directives” with a Law on End of Life Care.

  12. Las nuevas tecnologías en la información y comunicación: ¿para bien o para mal?

    OpenAIRE

    Lic. Emilce Castillo Obando

    1998-01-01

    Este artículo se ha elaborado con la finalidad de compartir algunas reflexiones alrededor de la trascendencia de las nuevas tecnologías de la información y comunicación en nuestras sociedades, debido a los riesgos culturales que plantean dichas tecnologías. Abordamos también los riesgos y efectos psicosociales y fisiológicos que puede producir el uso de estas tecnologías. También se hace una revisión de los planteamientos existentes a favor y en contra de las bondades de las nuevas tecnología...

  13. Cruz Peralta, Clemente, Los bienes de los santos: cofradías y hermandades de la Huasteca en la época colonial

    OpenAIRE

    Huerta Sánchez, Yasir Armando

    2015-01-01

    Originalmente presentado como un trabajo de tesis, el libro de la autoría de Clemente Cruz Peralta nos habla acerca de una institución que tras ser trasplantada desde España a sus posesiones americanas, marcaría la pauta en cuanto a la integración de diferentes grupos sociales y étnicos a través de los preceptos religiosos que le daría origen y justificaría su existencia: la cofradía; la cofradía se constituiría como una entidad sujeta al derecho canónico y al derecho real, y cuyas principale...

  14. Absceso y flegmón periamigdalino ¿Lo estamos haciendo bien? Abscess and cellulitis peritonsillar ¿Are we doing it right?

    OpenAIRE

    César Gómez V; Edda Pruzzo Ch; Eduardo Reyes S; María de los Angeles Contreras R; José Miguel Contreras R; Viviana Vergara T

    2006-01-01

    El flegmón (celulitis) y el absceso periamigdalino son infecciones difusas o una colección ubicada entre la cápsula fibrosa de la amígdala palatina, las fibras horizontales del músculo constrictor superior de la faringe y las verticales del músculo palatofaríngeo. Constituye la infección de tejidos y espacios profundos del cuello más frecuente. Material y método: Revisión retrospectiva de las fichas de pacientes adultos y niños hospitalizados con diagnóstico de absceso o flegmón periamigdalin...

  15. La etapa de los bienes globales en salud, una perspectiva nacional The age of public goods in health, a national perspective

    Directory of Open Access Journals (Sweden)

    José Ángel Córdova-Villalobos

    2008-01-01

    Full Text Available Los efectos adversos del tabaquismo sobre la salud han sido ampliamente reconocidos desde tiempo atrás. A pesar de todo, el tabaquismo no parece disminuir, con las inevitables consecuencias sobre la morbilidad y la mortalidad de millones de personas. Tan sólo en este año la OMS calcula que cinco millones de personas morirán por esta causa. En México, 26.2% de la población entre 15 y 65 años fuma con regularidad y el consumo se incrementa entre los jóvenes y las mujeres. La OMS adoptó el Convenio Marco para el Control del Tabaco, ratificado por México, lo que llevó a la creación de la Ley General para el Control del Tabaco, un importante hito en la política sanitaria mexicana, que próximamente será promulgada y que se espera tendrá un efecto notable en la contención de la epidemia de tabaquismo en el país.Adverse health effects from smoking have been widely known for a long time. Nevertheless, tobacco use does not appear to decrease, and with it the inevitable consequences on morbidity and mortality for millions of people continue. This year alone, the WHO calculates that five million people will die from tobacco use. In Mexico, 26.2% of the population between the ages of 15 and 65 smoke regularly and consumption increases among youth and women. The WHO adopted the Framework Convention on Tobacco Control, ratified by Mexico, which brought about the General Law for Tobacco Control, an important milestone in Mexican sanitary policy. This law will soon be in force and is expected to have a notable effect on containing the smoking epidemic in the country.

  16. El Puerto de La Laja (Huelva, como Bien de Interés Cultural en la categoría de Sitio Histórico

    Directory of Open Access Journals (Sweden)

    Emilio Romero Macías

    2010-10-01

    Full Text Available The Harbor of La Laja, it is a real example of recovery architecture of an ancient miner village for rural tourism exploitation. It is one of the possible bases of actions in the region of mines of the province of Huelva, to offer an alternative to sun and beach tourism, for knowledge of other cultures and as a development plan of areas that have been affected by the decline of mining in our province. Part of the village of the Harbor of La Laja has been currently restored for its exploitation for rural tourism, which is why the architecture in a way has tried to coordinate former arrangement of houses with fulfilled improvements for this type of use.

  17. Traite négrière transatlantique : comment a été pérennisée la production du bien esclave?

    OpenAIRE

    Kinvi Logossah

    2013-01-01

    Cet article montre que contrairement à ce que pouvaient laisser croire une littérature historique classique et une opinion largement répandue, la traite négrière transatlantique (TNTA) ne s’était pas développée à partir d’un esclavage interne africain préalable ou à partir de la traite musulmane qui l’avait précédée mais qu’il possédait des mécanismes vitaux propres. L’article met en évidence ces mécanismes vitaux propres et montre comment la dynamique économique qui en a résulté a assuré la ...

  18. Peculiaridades da terapia trombolítica na síndrome nefrótica pediátrica: monitorização do fator anti-Xa Particularities of thrombolytic therapy in pediatric nephrotic syndrome: anti-factor Xa monitoring

    OpenAIRE

    Patrícia Zambi Meirelles; Andréia Watanabe; Jorge David A. Carneiro; Vera Hermina K. Koch

    2008-01-01

    OBJETIVO: Descrever a importância do tromboembolismo pulmonar (TEP) na síndrome nefrótica pediátrica e o uso da heparina de baixo peso molecular como opção terapêutica segura e eficaz. DESCRIÇÃO DO CASO: Menino de 5,7 anos com síndrome nefrótica córtico-resistente e glomérulo-esclerose segmentar e focal foi internado devido à diarréia, distúrbios eletrolíticos e anasarca. No 11º dia de internação, evoluiu com desconforto respiratório súbito, cuja investigação mostrou área de alta probabilidad...

  19. Deuterium-induced nanostructure formation on tungsten exposed to high-flux plasma

    NARCIS (Netherlands)

    Xu, H.Y.; De Temmerman, G.; Luo, G. N.; Jia, Y. Z.; Yuan, Y.; Fu, B. Q.; Godfrey, A.; Liu, W.

    2015-01-01

    Surface topography of polycrystalline tungsten (W) have been examined after exposure to a low-energy (38&#xa0;eV/D), high-flux (∼1.1–1.5&#xa0;×&#xa0;1024&#xa0;m−2&#xa0;s−1) deuterium plasma in the Pilot-PSI linear plasma device. The methods used were scanning electron microscopy

  20. Study of the natural radiation background affected on the human body in some areas of Viet Nam

    International Nuclear Information System (INIS)

    The author had studied the natural radiation background in 68 districts belong 40 provinces and cities of Vietnam from 2002 to 2005. The estimated results clearly show that the average external irradiation dose levels and the average annual external radiation equivalent dose affected on the human body are 0.181± 0.0189 μSv/h and 1599 ± 171.8 μSv/year respectively, both are in normal limit; the highest levels are in Lai Chau district (Lai Chau province); the lowest levels are in Buon Ma Thuot city (DakLak province), Phuoc Son district (Quang Nam province), Tan An district (Long An province). The radon concentration in the human being and the average annual internal inhalation irradiation equivalent dose affected on the human beings are 26.9 ± 15.89 Bq/m3 and 392.88 ± 231.99 μSv/year respectively; the maximums are in Nha Trang city (Khanh Hoa province), Bac Binh district (Binh Phuoc province); the minimums are in Vung Tau city (Ba Ria- Vung Tau province), Tan An district (Long An province), Rach Gia district (Kien Giang province). The terrestrial radionuclide concentrations in the cereals, foodstuffs (rice, meat, vegetables), water, earth and the average annual internal irradiation equivalent dose are 829.2 ± 38.06 Bq/kg and 229.3 ± 67.70 μSv/year respectively; the highest levels are in Phong Tho district (Lai Chau province), Dien Bien city; the lowest levels are in Dong Xoai district (Binh Phuoc province), Tan An district (Long An province). The average total annual natural radiation background effective equivalent dose level affected on the human body is 2206.9 ± 529.30 μSv/year; the highest levels are in Lai Chau district (Lai Chau province); the lowest levels are in Tan An district (Long An province). The 14 maps of Natural Radiation Background in several localized regions belong 40 provinces and cities of Viet Nam had been set up. These results can reserve for serviceman and public health in the both wartime and peacetime. (author)

  1. Close linkage of a blast resistance gene, Pias(t), with a bacterial leaf blight resistance gene, Xa1-as(t), in a rice cultivar ‘Asominori’

    OpenAIRE

    Endo, Takashi; Yamaguchi, Masayuki; Kaji, Ryota; Nakagomi, Koji; Kataoka, Tomomori; Yokogami, Narifumi; Nakamura, Toshiki; Ishikawa, Goro; Yonemaru, Jun-ichi; Nishio, Takeshi

    2012-01-01

    It has long been known that a bacterial leaf blight-resistant line in rice obtained from a crossing using ‘Asominori’ as a resistant parent also has resistance to blast, but a blast resistance gene in ‘Asominori’ has not been investigated in detail. In the present study, a blast resistance gene in ‘Asominori’, tentatively named Pias(t), was revealed to be located within 162-kb region between DNA markers YX4-3 and NX4-1 on chromosome 4 and to be linked with an ‘Asominori’ allele of the bacteri...

  2. Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly lutzomyia longipalpis, blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo

    Czech Academy of Sciences Publication Activity Database

    Collin, N.; Assumpção, T.C.F.; Mizurini, D.M.; Gilmore, D.; Dutra-Oliveira, A.; Kotsyfakis, Michalis; Sa-Nunes, A.; Teixeira, C.; Ribeiro, J.M.C.; Monteiro, R.Q.; Valenzuela, J. G.; Francischetti, I.M.B.

    2012-01-01

    Roč. 32, č. 9 (2012), s. 2185-2198. ISSN 1079-5642 R&D Projects: GA ČR GAP502/12/2409 Institutional support: RVO:60077344 Keywords : hematophagy * leishmaniasis * microcirculation * thrombosis * vector biology Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.338, year: 2012 http://atvb.ahajournals.org/content/32/9/2185

  3. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor

    OpenAIRE

    Heeb, Mary J.; Prashun, Duane; Griffin, John H; Bouma, Bonno N.

    2009-01-01

    Protein S (PS) is a cofactor for activated protein C (APC), which inactivates coagulation factors (F) Va and VIIIa. Deficiency of protein C or PS is associated with risk of thrombosis. We found that PS also has APC-independent anticoagulant activity (PS-direct) and directly inhibits thrombin generated by FXa/FVa (prothrombinase complex). Here we report that PS contains Zn2+ that is required for PS-direct and that is lost during certain purification procedures. Immunoaffinity-purified PS conta...

  4. Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism.

    Directory of Open Access Journals (Sweden)

    Ashis K Mukherjee

    Full Text Available BACKGROUND: The monocled cobra (Naja kaouthia is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A2 (PLA2; EC 3.1.1.4 is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s for the differences in anticoagulant potency of two acidic PLA2 isoenzymes, Nk-PLA2α (13463.91 Da and Nk-PLA2β (13282.38 Da purified from the venom of N. kaouthia. PRINCIPAL FINDINGS: By LC-MS/MS analysis, these PLA2s showed highest similarity (23.5% sequence coverage with PLA2 III isolated from monocled cobra venom. The catalytic activity of Nk-PLA2β exceeds that of Nk-PLA2α. Heparin differentially regulated the catalytic and anticoagulant activities of these Nk-PLA2 isoenzymes. The anticoagulant potency of Nk-PLA2α was comparable to commercial anticoagulants warfarin, and heparin/antithrombin-III albeit Nk-PLA2β demonstrated highest anticoagulant activity. The anticoagulant action of these PLA2s was partially contributed by a small but specific hydrolysis of plasma phospholipids. The strong anticoagulant effect of Nk-PLA2α and Nk-PLA2β was achieved via preferential, non-enzymatic inhibition of FXa (Ki = 43 nM and thrombin (Ki = 8.3 nM, respectively. Kinetics study suggests that the Nk-PLA2 isoenzymes inhibit their "pharmacological target(s" by uncompetitive mechanism without the requirement of phospholipids/Ca(2+. The anticoagulant potency of Nk-PLA2β which is higher than that of Nk-PLA2α is corroborated by its superior catalytic activity, its higher capacity for binding to phosphatidylcholine, and its greater strength of thrombin inhibition. These PLA2 isoenzymes thus have evolved to affect haemostasis by different mechanisms. The Nk-PLA2β partially inhibited the thrombin-induced aggregation of mammalian platelets suggesting its therapeutic application in the prevention of unwanted clot formation. CONCLUSION/SIGNIFICANCE: In order to develop peptide-based superior anticoagulant therapeutics, future application of Nk-PLA2α and Nk-PLA2β for the treatment and/or prevention of cardiovascular disorders are proposed.

  5. Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study

    DEFF Research Database (Denmark)

    NN, NN

    2010-01-01

    in advanced development as an alternative to warfarin for the prevention and treatment of thromboembolic disorders. METHODS: ROCKET AF is a randomized, double-blind, double-dummy, event-driven trial, which aims to establish the noninferiority of rivaroxaban compared with warfarin in patients with...... nonmajor bleeding events. Over 14,000 patients have been randomized at 1,100 sites across 45 countries, and will be followed until 405 primary outcome events are observed. CONCLUSION: The ROCKET AF study will determine the efficacy and safety of rivaroxaban as an alternative to warfarin for the prevention...

  6. Bien gérer les "espaces de nature", une éthique du faire avec : propositions pour une géographie des Associations hétérogènes.

    OpenAIRE

    Tollis, Claire

    2012-01-01

    The “environmental crisis”, made public through various damages and threats that challenge the survival of our species (Larrère, 1997), urges our societies to include beings and phenomena that are not solely human into our moral sphere. Also, it requires to re-think the way we plan our activities in spaces than we share de facto with a large number of entities. This doctoral research focuses on “natural areas” management policies. Park and wilderness managers have to comply with an increasing...

  7. Quelle place pour les arcs \\'electriques et les r\\'eacteurs plasmas dans l'" Inventaire et valorisation des collections, archives scientifiques et biens culturels " de l'universit\\'e de Limoges ?

    CERN Document Server

    Pateyron, Bernard

    2011-01-01

    The University of Limoges in the rehabilitation of the premises was confronted with scientific disposal of property irreplaceable heritage in the context of "postmodern" or "post industrial" of our industrial society. Therefore a "scientific and cultural heritage Mission" was created in 2010 to save as much as possible the memory of the past half-century. For reasons we discuss plasmas and electric arcs have been an important place at that time in Western industry and especially by chance in Limoges.

  8. « C’est bien la loi d’un pays à forte émigration »:Principes de la nationalité et représentations de la nation au Liban

    OpenAIRE

    Jaulin, Thibaut

    2015-01-01

    Cet article interroge la relation entre la représentation du Liban comme pays d’émigration et la prééminence du droit du sang comme principe de la nationalité libanaise, au détriment du droit du sol. Par là, il se propose donc de poser des jalons pour comprendre la relation entre la nationalité, définie comme un facteur d’inclusion et d’exclusion, et l’invention de l’identité nationale libanaise. L’approche adoptée privilégie l’analyse des normes de la nationalité, plutôt que celle les pratiq...

  9. Economía del bien común y minifundismo en el sector agroalimentario: el caso del Celler de la Muntanya (Alicante) y la Marca MICROVIÑA

    OpenAIRE

    Compes López, Raúl; ASENSIO CALATAYUD, IÑAKI

    2014-01-01

    [EN] The article tackles in general terms the relationships between the Economy for the Common Good (ECG) and the Celler La Muntanya (Alicante), and specifically the implications resulting from the formal participation of a small agrifood firm into a comprehensive, complex and holistic system as the ECG. The case study methodology is employed and the data was obtained directly by the authors of the article. Although they share some features and objectives such as an alternative...

  10. Gérer des biens communs : processus de conception et régimes de coopération dans la gestion des ressources génétiques animales

    OpenAIRE

    Labatut, Julie

    2009-01-01

    The management of domestic animal genetic resources is a topic of pressing concern. Managing territorialized common goods of this kind calls for cooperative mechanisms involving a wider range of actors than before. How to steer these mechanisms, and handle the crises in cooperation that can impede them, is crucial to maintaining biodiversity. Starting from an analysis of the mechanisms for selecting local milk ewe breeds in the Western Pyrenees, this thesis seeks to show the value of a multi-...

  11. El enriquecimiento sin causa y la acción in rem versó en materia de responsabilidad estatal por realización de obras, prestación de servicios y suministro de bienes sin contrato estatal

    Directory of Open Access Journals (Sweden)

    Jaime Luis Arias Fonseca

    2013-09-01

    Full Text Available This paper examines bibliographically and under a critical rationale method the principle of unjust enrichment and action de in rem verso especially for Government liability derived from provided services, asset provision, and the execution of construction works in favor of the Government without any existing formal contract or when there is a wrongful contract between the Government and the contractor, thus, causing impoverishment to the latter and a correlative unjust enrichment to the former. To that effect, a brief historical review of these principles is performed; their notions, requirements, and functional conditions established by jurisprudence are revised; and finally, the current stance of the Administrative Court on the implementation of the unjust enrichment thesis and the merits of the actio de in rem verso in terms of Government liability in the abovementioned events is pointed out.

  12. Joseph Stiglitz, Amartya Sen, Jean-Paul Fitoussi, 2009, Richesse des nations et bien-être des individus, Préface de Nicolas Sarkozy, Paris : Odile Jacob, 326 p.

    Directory of Open Access Journals (Sweden)

    Stéphane Callens

    2010-12-01

    Full Text Available Les éditions Odile Jacob éditent avec une préface du Président de la République Française le rapport de la commission présidée par Joseph Stiglitz, rapport remis le 14 septembre 2009. La commande publique résulte du divorce entre les perceptions du public et les chiffres sur le pouvoir d’achat. La tonalité de l’introduction est volontaire, confiante dans l’élaboration d’un projet collectif pour provoquer le changement. Elle est aussi inquiète devant la crise financière et les conséquences éco...

  13. “En el principio era el logos” –¿o más bien el mythos? En torno al principio de la re-presentación en el judaísmo y el cristianismo

    OpenAIRE

    Bernhard Uhde

    2009-01-01

    Mito y logos se unen en la descripción del mito que admite una representación (Vergegenwärtigung) y es comprensible para el entendimiento: “muqologei=n”. De este modo, aquel logos que era “en el principio” es él mismo un mito, si no se hiciera presente (vergegenwärtigt) a sí mismo como logos. El principio de la religión, el Eterno mismo, deja narrar en el judaísmo un mito que culmina en un logos y puede ser interpretado como tal. En el cristianismo, la auto-re-presentación del principio de la...

  14. « Foin de ma barbe, si je n’ t’arrange une djellaba bien à ta taille ! ». Aspects de la dispute en pays berbère

    Directory of Open Access Journals (Sweden)

    Claude Lefébure

    2009-05-01

    Full Text Available Le champ clos de l’injure en pays d’oralité, c’est la dispute, la querelle verbale. Considérant l’ensemble des principaux groupes de parlers berbères, l’article examine donc d’abord les vocables porteurs de l’idée d’« agresser par le verbe » pour aboutir à cette observation que, comme dans d’autres langues, d’une famille différente même, ils ont partie liée avec l’idée d’« entamer un derme ». La littérature orale insiste : l’apex, depuis la bouche, blesse plus durablement qu’une arme de fer. Puis trois courts textes dûs à des locuteurs originaires des Ayt Sadden au Maroc, des Ayt Frah dans l’Aurès, des Irjen en Kabylie, sont scrutés pour ce qu’ils révèlent de la dispute en milieu berbère : un échange de paroles débridées et de formules figées associées à une gestuelle, dont l’association véhicule la menace physique et l’agression morale. Le corps est omniprésent, l’individu rapporté le plus souvent à sa lignée. Certains jeux verbaux s’assortissant dans le même milieu d’adresses et d’imprécations injurieuses, l’article y lit, pour finir, une propédeutique à la domestication des affrontements verbaux.

  15. Chances for the development of manufactures of capital goods. Analysis of the situation and sector evolution; Oportunidades para el desarrollo de los fabricantes de bienes de equipo. Analisis de la situacion y evolucion del sector

    Energy Technology Data Exchange (ETDEWEB)

    Pelaez Ramos, M. L.

    2012-07-01

    The main purpose of this paper is to analyze the situation and development in the capital goods sector in Spain. This industry is not just an important sector in the Spanish economy but, given its structural characteristics (dynamism, influence on the production processes of other activities and presence in all developed countries), it conditions the recovery of our economy. The article includes an analysis of the weaknesses, threats, strengths and opportunities of the sector. Further, it is crucial its contribution to make sustainable development of industrial activity. Also, it deals with those opportunities that are presented for the future development of this industry such as eco-design, energy efficiency and life cycle analysis. (Author)

  16. Evaluation of the efficiency of bismuth breast shield in CT chest paediatric examinations; Valoracion en el paciente pediatrico de la eficacia de los protectores de bien procedimientos de TC de torax con sistemas de control automatico de intensidad

    Energy Technology Data Exchange (ETDEWEB)

    Sevillano, D.; Espana, M. L.; Castro, P.; Minguez, C.; Albi, G.; Garcia, E.; Lopez Franco, P.

    2006-07-01

    The aim of this study is to evaluate the efficiency of bismuth breast shield in CT chest paediatric examinations when automatic exposure control techniques are used. The influence in the radiation dose and the image quality has been evaluated with and without the breast shield in the scoutview. In addition the radiation dose in shielded and non-shielded areas has been compared. Measurements were made in a 16 cm diameter cylindrical PMMA phantom simulating a newborn, and older children were simulated controlling the maximum intensities allowed by the automatic exposure control system AutomA. The highest dose reduction (59%) was obtained with AutomA system and when the breast shield is not used in the scoutview. This reduction in the radiation dose does not mean a significant increase of noise level. The use of the breast shield in the scoutview yielded an increase in the radiation dose in non-shielded areas. The use of bismuth breast shield is recommended only after the scoutview in order to optimise the radiation dose in CT chest paediatric examination when using automatic exposure control AutomA. (Author)

  17. Cada uno en su sitio, en el adosado de "España va bien". Aproximación a los aspectos ideológicos de la serie de TV 'Médico de familia'

    Directory of Open Access Journals (Sweden)

    Lic. Rodolfo Giner Casado

    1998-01-01

    Full Text Available En la serie Familia Kft, de gran éxito esta temporada en la televisión húngara, se ha incluido a un nuevo personaje, por iniciativa del Ministerio de Defensa. Se trata de un militar cuyo papel es, con ayuda de los diálogos previstos a tal fin en el guión, alabar los méritos de la adhesión de Hungría a la OTAN. Este caso puede parecer una anécdota, pero ilustra perfectamente cómo la ficción televisiva, por las grandes audiencias que alcanza, es utilizada de forma más o menos explícita para generar en los espectadores consenso en torno a postulados deseables para quienes controlan los medios audiovisuales. En el caso español, donde las televisiones privadas están plenamente asentadas desde principios de la década y son las que cuentan con una mayor y más exitosa oferta de ficción, la presencia de campañas gubernamentales es menos evidente. Sin embargo, se impone la lógica del mercado y son los anunciantes y patrocinadores de los programas quienes insuflan en la ficción su visión de una sociedad en la que los ciudadanos se convierten en consumidores. El informe español presentado recientemente en la reunión anual del observatorio Eurofiction señala que, durante 1996, las televisiones españolas emitieron 459 horas de ficción, de las que el 62 por ciento eran series, entre las que predominaba la comedia familiar (16 títulos, 66 por ciento de la ficción emitida frente al drama (6 títulos, 34 por ciento de lo emitido. Según el informe, las características comunes a todas estas series, son su vocación familiar, intergeneracional e interclasista, el tratamiento poco conflictivo de cuestiones sociales, el ambiente urbano y el hecho de que en su mayor parte giran en torno a un personaje famoso. El ejemplo más evidente de este tipo de series es Médico de familia.

  18. Una mirada de los aspectos económicos, simbólicos y emocionales como parte de un conjunto de prácticas que determinan experiencias de consumo de bienes de lujo

    Directory of Open Access Journals (Sweden)

    Mauricio Edgardo Muñoz Osores

    2015-03-01

    Full Text Available El presente trabajo tiene por objeto, identificar y comprender las actitudes manifiestas por un grupo de consumidores de segmentos diferenciados, en relación al proceso de decisión de compra de marcas de lujo en dos regiones del país. A partir de sesiones de discusión en grupos y un posterior análisis cualitativo, se pretende obtener una conceptualización determinada sobre el significado de marca de lujo, los diferentes estados de bienestar o satisfacción generados por estas, así como también, la identificación de ciertas marcas que puedan clasificarse como de “lujo tradicional” y “nuevo lujo”. Este último punto es de gran relevancia para establecer y reconocer diferencias substanciales en el mercado del consumo de marcas de lujo, dado que por lo establecido en la presente investigación, el perfil o naturaleza de los compradores difiere, en términos de capacidad, frecuencia y motivos de compra. The present work aims to, identify and understand the manifest attitudes by a group of consumers of different segments, in relation to the decision-making process of purchase of brands of luxury in two regions of the country. From discussion groups and a subsequent qualitative analysis sessions, is expected to obtain a particular conceptualization about the meaning of luxury brand, different States of well-being or satisfaction generated by these, as well as the identification of certain brands that may be classified as “traditional luxury” and “new luxury”. This last point is of great importance to establish and recognize substantial di erences in the consumer market of luxury brands, given that by what is established in the present investigation, the pro le or nature of buyers differs, in terms of capacity, frequency and reasons for purchase.

  19. La privatización de la ciencia y el conocimiento: el cercamiento de los bienes comunes. Las patentes en biotecnología: el caso de las secuencias genéticas

    OpenAIRE

    Miguel Sánchez Padrón

    2003-01-01

    La privatización de áreas insospechadas del patrimonio colectivo de la humanidad ha adquirido en los últimos años carta de naturaleza. Uno de los instrumentos principales para abrir el sendero y legitimar dicha privatización son las patentes. El análisis de estas entidades legales se tropieza, sin embargo, con su interdisciplinariedad. En las patentes confluyen tres espacios: la economía, las leyes y la tecnología. El espíritu que anima este trabajo es construir un puente entre estos espacios...

  20. "Me urge se me suministre de sus bienes los alimentos": estrategias femeninas en la resolución de conflictos domésticos. 1800-1850, Valle Central de Chile

    Directory of Open Access Journals (Sweden)

    Valentina Bravo Olmedo

    2016-01-01

    Full Text Available El presente artículo tiene por objetivo analizar las prácticas de resolución de conflictos domésticos de las mujeres ante la justicia en los Partidos de Quillota, Aconcagua y Santiago entre 1800 y 1850, a través de la revisión de juicios civiles por pensión de alimentos entablados por mujeres casadas y solas. El periodo a analizar representa un proceso de legitimación de un régimen jurídico institucional. No obstante, las prácticas de resolución de conflictos estuvieron acompañadas de prácticas fronterizas, donde la ley y la costumbre estuvieron en permanente dialogo. En este contexto, proponemos que las mujeres recurrieron a la justicia institucional reclamando protección masculina para ellas y sus hijos, como parte de un sinfín de estrategias que se enmarcaban dentro de la justicia negociada, lo cual implicó, por parte de éstas, un desarrollo de estrategias que involucraron la resistencia de género, cultura jurídica y la publicidad del conflicto. De esto, distinguimos que las mujeres casadas, amparadas por la institución matrimonial, impulsaron estrategias apegadas a los ideales hegemónicos asegurando una pensión que correspondiera a sus necesidades. En cambio, las mujeres solas tuvieron que recurrir a estrategias más amplias y fronterizas que comprometía la solidaridad de sus cercanos, la divulgación del conflicto y  el honor femenino.

  1. Les PME en France en 2011 : malgré une activité bien orientée, la rentabilité stagne et les structures financières demeurent hétérogènes.

    OpenAIRE

    CAYSSIALS, J-L.; Servant, F.

    2012-01-01

    Le redémarrage de l’activité des PME résidant en France se confirme en 2011, notamment grâce à un rebond des exportations, mais la fin d’année marque les prémices d’une inflexion. Le taux de marge augmente légèrement, tandis que le taux d’épargne se replie. L’investissement progresse, surtout pour les PME de l’industrie. Les capitaux propres continuent à se renforcer.

  2. Conceptos básicos de políticas inteligentes y economía del bien común. Un estudio interdisciplinar desde la experiencia en las Aulas

    OpenAIRE

    Ortiz García, Mercedes; Garay Montañez, Nilda; Gómez Calvo, Verónica; Hidalgo Moratal, Moisés; Carmen PASTOR SEMPERE; Romero-Tarín, Adela

    2013-01-01

    El carácter crítico constructivo de la investigación y la enseñanza universitaria está estrechamente vinculado con los valores/principios/conceptos de sostenibilidad, justicia, igualdad, gobernanza, democracia y progreso. Dado que la persona es el centro de la organización social ésta tiene que responder a un modelo político-jurídico, económico y social que le favorezca. De ahí que esta Red Docente tenga como objetivo la aplicación interdisciplinar de los citados valores/conceptos en los cont...

  3. Are the Kids Alright? What's Shaping the Attitudes, Values and Behaviour of our Young People? = Les enfants se portent-ils bien? Qu'est-ce qui faconne les attitudes, les valeurs et le comportement de nos jeunes?

    Science.gov (United States)

    Theilheimer, Ish, Ed.

    1992-01-01

    This theme issue explores the behavior of teenagers. "Are the Kids Alright?" (Ish Theilheimer) develops a perspective on the subject of teen behavior, noting that a growing number of young people demonstrate discontent, alienation, aggression, violence, and antisocial behavior, and that a growing underclass of children is likely to fail. The…

  4. [Recurso de apelación del abad y cabildo de la Iglesia Colegial del Sacromonte en el pleito contra Juan Bazán e Isabel y Francisca de Villalta por el usufructo de unos bienes.

    OpenAIRE

    2014-01-01

    "Para lo qual se supone. Lo primero que Don Juan Bazan y Doña Geronima [...]" Manuscrito 3 h. Papel 223x310mm. Texto en: Castellano Letra bastarda. Vivas Moreno, Agustín. “Fondos documentales del Archivo Histórico de la Universidad de Salamanca. La colección de Papeles Varios: análisis descriptivo, tesauro y gestión documental automatizada”. Tesis doctoral, 1999. Las descripciones fueron cedidas por su autor. Conservación buena

  5. Action protocol for the protection of cultural property after the earthquake at Lorca (2011); Protocolo de actuacion para la proteccion de los bienes culturales de Lorca tras el terremoto de 2011

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Rios, C.

    2012-11-01

    After the earthquakes of 11 May 2011 at Lorca, the Directorate General of Cultural Assets of the CARM, as the body responsible for protecting cultural heritage in the Region of Murcia, was in Lorca to initiate emergency procedures in the affected monuments of the historic city centre. In co-ordination with the City Council of Lorca, the Ministry of Culture and the Diocese of Cartagena, during the first day inspections were made of the castle of Lorca, the collegiate church of San Patricio, the Guevara palace, the porch of San Antonio, the church of Santo Domingo and the Rosary chapel , the church and convent of San Francisco, the church of Nuestra Senora del Carmen and the church of La Virgen de las Huertas, among other cultural sites. The severity of the damage to buildings having been verified, a protocol was established to appoint an architect and construction company to assess the damage and take all necessary measures. The rapid response of the different groups was instrumental in establishing minimum guarantees of stability and the removal of elements at risk of collapse. With regard to movable fixtures and ornaments, emergency action was coordinated by the Regional Centre for Restoration and Museum and Exhibition Service of the Directorate General for Cultural Property, which proceeded to assess the damage and adopt protective measures for the protection of altarpieces in churches and the packaging, transport and storage of works belonging to the Guevara palace. (Author) 28 refs.

  6. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado

    OpenAIRE

    Juan Lopera-Vasquez; Vaughan Bell; Carlos López-Jaramillo

    2011-01-01

    Background: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistical variance attributed to primary executive function deficits. This study tests the hypothesis that verbal memory deficits in bipolar patients are largely the result of executive difficulties by ...

  7. ¿Por qué Leer Bien es Importante?: Asociación del Dominio Lector con Otros Aprendizajes Why Reading Well is so Important?: Association Between Reading Mastery and Other Learning Processes

    OpenAIRE

    Teresa Marchant; Graciela Lucchini; Blanca Cuadrado

    2007-01-01

    Fundación Educacional Arauco1 (Fundar), a partir de los datos obtenidos en las evaluaciones de sus distintos programas e investigaciones, realizó un estudio en una muestra de 1782 alumnos de 2° a 8º básico de distintas regiones de Chile, evaluados entre los años 2001 y 2005, con el objetivo de analizar la asociación entre el Dominio Lector y el desempeño en otras áreas de aprendizaje. Los resultados de este estudio muestran una significativa asociación entre la Calidad de Lectura Oral de los ...

  8. ¿Por qué Leer Bien es Importante?: Asociación del Dominio Lector con Otros Aprendizajes Why Reading Well is so Important?: Association Between Reading Mastery and Other Learning Processes

    Directory of Open Access Journals (Sweden)

    Teresa Marchant

    2007-11-01

    Full Text Available Fundación Educacional Arauco1 (Fundar, a partir de los datos obtenidos en las evaluaciones de sus distintos programas e investigaciones, realizó un estudio en una muestra de 1782 alumnos de 2° a 8º básico de distintas regiones de Chile, evaluados entre los años 2001 y 2005, con el objetivo de analizar la asociación entre el Dominio Lector y el desempeño en otras áreas de aprendizaje. Los resultados de este estudio muestran una significativa asociación entre la Calidad de Lectura Oral de los alumnos y el dominio de distintas habilidades como comprensión lectora, vocabulario y redacción, el mejor uso de contenidos de lenguaje, matemática y comprensión del medio, además del desarrollo de la autoestima. Interesa compartir estos resultados para destacar la importancia de desarrollar tempranamente, junto con otras habilidades, el proceso lector de los alumnos y fortalecerlo hasta lograr su total dominio."Fundación Educacional Arauco (Fundar" using data from the evaluation of programs and research, from different counties of Chile during the years 2001 to 2005, conducted a study of 1782 students from first to eight grade, to analize the association between Level of Reading Mastery and their performance in other areas of learning. The results of this study show a significant association between the students level of "Oral Reading Quality" and their performance in different skills such as reading comprehension, use of vocabulary and writing, the management of contents in Language, Mathematics, History and Science, as well as with their level self-esteem. It is interesting to share these results in order to enhance the importance of early development of the student's reading process, together with other skills, and to strengthen it until they reach full mastery.

  9. Nouvelles méthodes d'analyse du bien-être et moyens d'évaluation des programmes de lutte contre la pauvreté en milieu rural sénégalais

    OpenAIRE

    Mbaye, Samba

    2010-01-01

    Fighting against poverty is being since now one of the main preoccupations of populations and governmental authorities in Senegal. Substantial efforts have been engaged over the last decade and many projects operating on poverty reduction have been implemented. Among these projects, National Rural Infrastructure Program (PNIR) is appeared as one of the most relevant. Its objectives was to build basic social infrastructures in order to improve living conditions of rural populations. The main g...

  10. La coopétition au service du bien commun. Les stratégies de entreprises de collecte et de stockage de céréales face aux OGM

    OpenAIRE

    Hannachi, Mourad

    2011-01-01

    Cette thèse a étudié comment des entreprises s’organisent pour gérer collectivement la présence ou l’absence des OGM au niveau du territoire agricole. A partir de plusieurs études de cas, cette recherche montre que des entreprises de collecte et de stockage ont pu fédérer, coordonner ou influencer l’ensemble des opérateurs pour gérer leur territoire. Nos résultats révèlent que cela passe par des relations de coopération entre des opérateurs en concurrence directe sur les marchés et des straté...

  11. Avantages organisationnels des dispositions d'esprit alternatives : comment les techniques de méditation améliorent le bien-être et la production créative parmi les employés.

    OpenAIRE

    Holm, Marie,

    2013-01-01

    Ln contrast to the traditional mindset (TMS)-the conscious awareness, controlled mental processes, and analytical-logical manipulation of symbols-an alternative mindset (AMS) is viewed as the pre-conscious mental processes (i.e. associative, imaginative, intuitive) and holistic thinking (Davis- Floyd and Arvidson, 1997; Dane and Pratt, 2007; Hodgkinson et al 2009). Since Plato, the West has considered TMS as the hallmark of intelligence and simply of any cognition. Yet, in recent decades vari...

  12. Les instruments juridiques de la protection des intérêts diffus et des biens collectifs :. Le rôle des pouvoirs privés et la rentrée des pouvoirs publics

    OpenAIRE

    Jacques Ziller

    2003-01-01

    LEGAL INSTRUMENTS FOR THE PROTECTION OF DIFFUSE INTERESTS AND COLLECTIVE GOODS : THE ROLE OF PRIVATE ACTORS AND THE RETURN OF PUBLIC POWER This paper starts with the presentation of a few venues for a research programme. Contemporary and comparative legal history could try and find out more about the correlation between globalisation, regionalisation (especially European integration) and the loss of impact of notions such as the general interest as a standard for legislators and judges, and t...

  13. QTL Information Table: 402 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Xa4 Resistance or Tolerance Bacterial blight resistance bacterial blight resistance RFLP B)Fine ... ., and Zhang, Q. (2003). Identification of a 47-kb DNA ... fragment containing Xa4, a locus for bacterial bli ...

  14. Drug: D04113 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04113 Mixture, Drug Boric acid - Inorganic salt mixt; Artificial tear mytear (TN) ...PHTHALMOLOGICALS S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA20 Artificial

  15. Model-Based Illumination Correction for Face Images in Uncontrolled Scenarios

    NARCIS (Netherlands)

    Boom, Bas; Spreeuwers, Luuk; Veldhuis, Raymond

    2009-01-01

    Face Recognition under uncontrolled illumination conditions is partly an unsolved problem. Several illumination correction methods have been proposed, but these are usually tested on illumination conditions created in a laboratory. Our focus is more on uncontrolled conditions. We use the Phong model

  16. The Effects of Communicative Grammar Teaching on Students' Achievement of Grammatical Knowledge and Oral Production

    Science.gov (United States)

    Ho, Pham Vu Phi; The Binh, Nguyen

    2014-01-01

    So far the students of Le Hong Phong Junior High School have been taught grammar with GTM (Grammar-Translation Method), which just prepares learners for conventional grammar-paper tests. Despite their considerable knowledge of grammar, the students fail to use the language they have learnt to communicate in real-life situations. The purpose of…

  17. Nucleotide diversity analysis of three major bacterial blight resistance genes in rice.

    Directory of Open Access Journals (Sweden)

    Waikhom Bimolata

    Full Text Available Nucleotide sequence polymorphisms among R gene alleles influence the process of co-evolutionary interaction between host and pathogen by shaping the response of host plants towards invading pathogens. Here, we present the DNA sequence polymorphisms and diversities present among natural alleles of three rice bacterial blight resistance genes, Xa21, Xa26 and xa5. The diversity was examined across different wild relatives and cultivars of Oryza species. Functional significance of selected alleles was evaluated through semi-quantitative reverse transcription polymerase chain reaction and real time PCR. The greatest nucleotide diversity and singleton variable sites (SVS were present in Xa26 (π = 0.01958; SVS = 182 followed by xa5 and Xa21 alleles. The highest frequency of single nucleotide polymorphisms were observed in Xa21 alleles and least in xa5. Transition bias was observed in all the genes and 'G' to 'A' transitions were more favored than other form of transitions. Neutrality tests failed to show the presence of selection at these loci, though negative Tajima's D values indicate the presence of a rare form of polymorphisms. At the interspecies level, O. nivara exhibited more diversity than O. sativa. We have also identified two nearly identical resistant alleles of xa5 and two sequentially identical alleles of Xa21. The alleles of xa5 showed basal levels of expression while Xa21 alleles were functionally not expressed.

  18. Somatic mutations in three nucleus genes of pea after treatment of seeds with X-rays and ethyl methane sulfonate

    International Nuclear Information System (INIS)

    Using leaves of pea plants, heterozygous in yellow chlorophyll mutations xa-16, xa-17 and xa-18, a spontaneuos appearance of spots and sectors of mutant phenotype is detected. The line xa -18 is cracterized by a low spontaneous frequency of sector appearapce (0.002), the line xa-16 - by a medium (0.012), the line xa-17 - by the highest one 0.0865). It is shown that yellow spots and sectors, appearing on leaves of green plants from the lines xa-16, xa-17 and xa-18, are not connected with physiological violations and can appear as a result of mutation changes in a specific locus, which is in the heterozygous state in each of the three lines. Under the effect ionizing radiation and chemical mutagene of ethylmethanesulfonate (EMS) the frequency of sectors in the line xa-R17 increased by a factor of 4-6, and in the lines xa-16 and xa-18 - by a factor of 1a-70. Increase of sector frequency under the effect of mutagenous factors confirms the mutation nature of yellow sectors, appearing as a result of loss or change of dominant marker (Aa → a). Point mutations and deletions of dominant allele of a specific locus are pointed out as the most probable genetic events, resulting in the appearance of mutant sectors

  19. Xanthurenic acid is localized in neurons in the central nervous system.

    Science.gov (United States)

    Roussel, Guy; Bessede, Alban; Klein, Christian; Maitre, Michel; Mensah-Nyagan, Ayikoe Guy

    2016-08-01

    Kynurenine pathway metabolites (KPM) are thought to be synthesized mainly by non-neuronal cells in the mammalian brain. KPM are of particular interest because several studies demonstrated their implication in various disorders of the nervous system. Among KPM is xanthurenic acid (XA) deriving from the catabolism of 3-hydroxykynurenine. Based on its chemical structure, XA appears as a close analog of kynurenic acid which has been extensively investigated and is considered as a potent neuroprotective compound. Contrary to kynurenic acid (KYNA), XA has received little attention and its role in the brain remains not elucidated. We have previously described several characteristics of XA, suggesting its possible involvement in neurotransmission. XA is also proposed as a potential modulator at glutamatergic synapses. Here, we used a selective antibody against XA and various neuronal, glial and synaptic markers to show that XA is essentially localized in the soma and dendrites of brain neurons, but is absent from axonal compartments and terminal endings. Our results also reveal that XA-like immunoreactivity is not expressed by glial cells. To double-check our findings, we have also used another XA antibody obtained from a commercial source to confirm the neuronal expression of XA. Together, our results suggest that, differently to several other KPM produced by glial cells, XA exhibits a neuronal distribution in the mouse brain. PMID:27167083

  20. Modular forms and three-loop superstring amplitudes

    International Nuclear Information System (INIS)

    We study a proposal of D'Hoker and Phong for the chiral superstring measure for genus three. A minor modification of the constraints they impose on certain Siegel modular forms leads to a unique solution. We reduce the problem of finding these modular forms, which depend on an even spin structure, to finding a modular form of weight 8 on a certain subgroup of the modular group. An explicit formula for this form, as a polynomial in the even theta constants, is given. We checked that our result is consistent with the vanishing of the cosmological constant. We also verified a conjecture of D'Hoker and Phong on modular forms in genus 3 and 4 using results of Igusa

  1. Modular forms and three-loop superstring amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Cacciatori, Sergio L. [Dipartimento di Scienze Fisiche e Matematiche, Universita dell' Insubria, Via Valleggio 11, I-22100 Como (Italy)], E-mail: sergio.cacciatori@uninsubria.it; Dalla Piazza, Francesco [Dipartimento di Scienze Fisiche e Matematiche, Universita dell' Insubria, Via Valleggio 11, I-22100 Como (Italy)], E-mail: f.dallapiazza@uninsubria.it; Geemen, Bert van [Dipartimento di Matematica, Universita di Milano, Via Saldini 50, I-20133 Milano (Italy)], E-mail: geemen@mat.unimi.it

    2008-09-11

    We study a proposal of D'Hoker and Phong for the chiral superstring measure for genus three. A minor modification of the constraints they impose on certain Siegel modular forms leads to a unique solution. We reduce the problem of finding these modular forms, which depend on an even spin structure, to finding a modular form of weight 8 on a certain subgroup of the modular group. An explicit formula for this form, as a polynomial in the even theta constants, is given. We checked that our result is consistent with the vanishing of the cosmological constant. We also verified a conjecture of D'Hoker and Phong on modular forms in genus 3 and 4 using results of Igusa.

  2. Fauna Europaea: Helminths (Animal Parasitic)

    OpenAIRE

    David Gibson; Rodney Bray; David Hunt; Boyko Georgiev; Tomaš Scholz; Philip Harris; Tor Bakke; Teresa Pojmanska; Katarzyna Niewiadomska; Aneta Kostadinova; Vasyl Tkach; Odile Bain; Marie-Claude Durette-Desset; Lynda Gibbons; František Moravec

    2014-01-01

    The Laotian Rock Rat Laonastes aenigmamus Jenkins, Kilpatrick, Robinson & Timmins, 2005 was originally discovered in Lao People's Democratic Republic in 2005. This species has been recognized as the sole surviving member of the otherwise extinct rodent family Diatomyidae. Laonastes aenigmamus was initially reported only in limestone forests of Khammouane Province, Central Lao. A second population was recently discovered in Phong Nha Ke Bang National Park (PNKB NP), Quang Binh P...

  3. Remarks on Superstring amplitudes in higher genus

    OpenAIRE

    Manni, Riccardo Salvati

    2008-01-01

    Very recently, Grushevsky continued D'Hoker and Phong's program of finding the chiral superstring measure from first principles by constructing modular forms satisfying certain factorization constraints. He has proposed an ansatz in genus 4 and conjectured a possible formula for the superstring measure in any genus, subject to the condition that certain modular forms admit holomorphic roots. In this note we want to give some evidence that Grushevsky's approach seems to be very fruitful.

  4. High occurrence of viruses in the mucus layer of scleractinian corals

    OpenAIRE

    Nguyen-Kim, H.; Bouvier, T.; Bouvier, C.; Hai, D. N.; Lam, N. N.; Rochelle Newall, Emma; Baudoux, A.C.; Desnues, C.; Reynaud, S.; Ferrier-Pages, C.; Bettarel, Yvan

    2014-01-01

    Viruses attract increasing interest from environmental microbiologists seeking to understand their function and role in coral health. However, little is known about their main ecological traits within the coral holobiont. In this study, a quantitative and qualitative characterization of viral and bacterial communities was conducted on the mucus of seven different coral species of the Van Phong Bay (Vietnam). On average, the concentrations of viruses and bacteria were, respectively, 17- and tw...

  5. Improved Algorithms for Fast Shading and Lighting

    OpenAIRE

    Hast, Anders

    2004-01-01

    Shading is a technique that is used in computer graphics to make faceted objects appear smooth and more realistic. In the research presented in this thesis we have investigated how shading can be generated as efficiently as possible without sacrificing quality. In the classical approach to high quality shading proposed by Phong, the illumination equation is computed per pixel using an interpolated normal. The normals at the vertices are bi-linearly interpolated over the polygon to obtain a n...

  6. A dengue outbreak on a floating village at Cat Ba Island in Vietnam

    OpenAIRE

    Viet, T. Le; CHOISY, M.; Bryant, J.E.; Trong, D. Vu; Quang, T. Pham; Horby, P; Tran, H.; Kieu, H. Tran Thi; Vu, T. Nguyen; Van, K. Nguyen; Quynh, M. Le; Wertheim, H. F. L.

    2015-01-01

    Background A dengue outbreak in an ecotourism destination spot in Vietnam, from September to November 2013, impacted a floating village of fishermen on the coastal island of Cat Ba. The outbreak raises questions about how tourism may impact disease spread in rural areas. Methods Epidemiological data were obtained from the Hai Phong Preventive Medical Center (PMC), including case histories and residential location from all notified dengue cases from this outbreak. All household addresses were ...

  7. EVALUATING JOB SATISFACTION LEVELS : Case: Truong An Joint Stock Company (TACO)

    OpenAIRE

    Pham, My Linh

    2016-01-01

    Truong An Joint Stock Company (TACO) is garment producing company, which is located in Hai Phong, Vietnam. The main business is completing the outsourcing orders from foreign companies. TACO is also a long-term partner with variety of domestic enterprises. The thesis aimed to identify factors which affect the levels of job satisfaction in TACO. The current status quo of TACO employees’ satisfaction was measured; it has been the useful data source for targeting the strength to encourage and th...

  8. Construction of Realistic Scene in Virtual Turning Based on Global Illumination Model and Chip Simulation

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    With the rapid development of manufacturing technology, the traditional simulation of machining can not meet the people's need. Research on virtual machining environment is one of the key parts of virtual manufacturing technology. According to the features of virtual turning, this paper proposes a simplified Whitted lighting model based on analysis of Phong and other local illumination model. This model takes the material and roughness of workpiece into account to calculate the roughness coefficient D, geom...

  9. Distribution and habitat of the Laotian Rock Rat Laonastes aenigmamus Jenkins, Kilpatrick, Robinson & Timmins, 2005 (Rodentia: Diatomyidae) in Vietnam

    OpenAIRE

    Nguyen, Dang; Nguyen, Nghia; Nguyen, Duy; Dinh,Tri; Le,Dinh; Duong,Dinh

    2014-01-01

    The Laotian Rock Rat Laonastes aenigmamus Jenkins, Kilpatrick, Robinson & Timmins, 2005 was originally discovered in Lao People's Democratic Republic in 2005. This species has been recognized as the sole surviving member of the otherwise extinct rodent family Diatomyidae. Laonastes aenigmamus was initially reported only in limestone forests of Khammouane Province, Central Lao. A second population was recently discovered in Phong Nha Ke Bang National Park (PNKB NP), Quang Binh Province, Centra...

  10. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from LPS-stimulated myeloid cells.

    LENUS (Irish Health Repository)

    Gleeson, Eimear M

    2013-07-19

    Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease crucial for blood coagulation, also induces protease-activated receptor-dependent cell signaling. Factor Xa can bind both monocytes and macrophages, but whether factor Xa-dependent signaling stimulates or suppresses myeloid cell cytokine production in response to Toll-like receptor activation is not known. In this study, exposure to factor Xa significantly impaired pro-inflammatory cytokine production from lipopolysaccharide-treated peripheral blood mononuclear cells, THP-1 monocytic cells and murine macrophages. Furthermore, factor Xa inhibited nuclear factor-kappa B activation in THP-1 reporter cells, requiring phosphatidylinositide 3-kinase activity for its anti-inflammatory effect. Active-site blockade, γ-carboxyglutamic acid domain truncation and a peptide mimic of the factor Xa inter-epidermal growth factor-like region prevented factor Xa inhibition of lipopolysaccharide-induced tumour necrosis factor-α release. In addition, factor Xa anti-inflammatory activity was markedly attenuated by the presence of an antagonist of protease-activated receptor 2, but not protease-activated receptor 1. The key role of protease-activated receptor 2 in eliciting factor Xa-dependent anti-inflammatory signaling on macrophages was further underscored by the inability of factor Xa to mediate inhibition of tumour necrosis factor-α and interleukin-6 release from murine bone marrow-derived protease-activated receptor 2-deficient macrophages. We also show for the first time that, in addition to protease-activated receptor 2, factor Xa requires a receptor-associated protein-sensitive low-density lipoprotein receptor to inhibit lipopolysaccharide-induced cytokine production. Collectively, this study supports a novel function for factor Xa as an endogenous, receptor

  11. Drug: D01790 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01790 Drug Oxaliplatin (JAN/USAN/INN); Eloxatin (TN) Pt. C6H14N2. C2O4 397.0601 397.2918 D01790 ... STIC AGENTS L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum ... compounds L01XA03 Oxaliplatin D01790 Oxaliplatin ( ... NN) Antineoplastics [BR:br08308] Alkylating agents Platinum ... compounds Oxaliplatin [ATC:L01XA03] D01790 Oxalipl ...

  12. Drug: D05807 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05807 Drug Satraplatin (USAN/INN) C4H6Cl2O4Pt. C6H13N. NH3 499.0604 500.2827 D05807.gif Antineo ... STIC AGENTS L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum ... compounds L01XA04 Satraplatin D05807 Satraplatin ( ... NN) Antineoplastics [BR:br08308] Alkylating agents Platinum ... compounds Satraplatin [ATC:L01XA04] D05807 Satrapl ...

  13. Drug: D00275 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00275 Drug Cisplatin (JP16/USP/INN); Platinol (TN) PtCl2. 2NH3 298.9556 300.051 D00275.gif Anti ... STIC AGENTS L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum ... compounds L01XA01 Cisplatin D00275 Cisplatin (JP16 ... NN) Antineoplastics [BR:br08308] Alkylating agents Platinum ... compounds Cisplatin [ATC:L01XA01] D00275 Cisplatin ...

  14. Drug: D01363 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01363 Drug Carboplatin (JP16/USP/INN); Paraplatin (TN) C6H6O4Pt. 2NH3 371.0445 371.2545 D01363. ... STIC AGENTS L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum ... compounds L01XA02 Carboplatin D01363 Carboplatin ( ... NN) Antineoplastics [BR:br08308] Alkylating agents Platinum ... compounds Carboplatin [ATC:L01XA02] D01363 Carbopl ...

  15. Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20.

    Science.gov (United States)

    Taleb, Omar; Maammar, Mohammed; Brumaru, Daniel; Bourguignon, Jean-Jacques; Schmitt, Martine; Klein, Christian; Kemmel, Véronique; Maitre, Michel; Mensah-Nyagan, Ayikoe Guy

    2012-01-01

    Xanthurenic acid (XA) is a metabolite of the tryptophan oxidation pathway through kynurenine and 3-hydroxykynurenine. XA was until now considered as a detoxification compound and dead-end product reducing accumulation of reactive radical species. Apart from a specific role for XA in the signaling cascade resulting in gamete maturation in mosquitoes, nothing was known about its functions in other species including mammals. Based upon XA distribution, transport, accumulation and release in the rat brain, we have recently suggested that XA may potentially be involved in neurotransmission/neuromodulation, assuming that neurons presumably express specific XA receptors. Recently, it has been shown that XA could act as a positive allosteric ligand for class II metabotropic glutamate receptors. This finding reinforces the proposed signaling role of XA in brain. Our present results provide several lines of evidence in favor of the existence of specific receptors for XA in the brain. First, binding experiments combined with autoradiography and time-course analysis led to the characterization of XA binding sites in the rat brain. Second, specific kinetic and pharmacological properties exhibited by these binding sites are in favor of G-protein-coupled receptors (GPCR). Finally, in patch-clamp and calcium imaging experiments using NCB-20 cells that do not express glutamate-induced calcium signals, XA elicited specific responses involving activation of cationic channels and increases in intracellular Ca(2+) concentration. Altogether, these results suggest that XA, acting through a GPCR-induced cationic channel modulatory mechanism, may exert excitatory functions in various brain neuronal pathways. PMID:23139790

  16. Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20.

    Directory of Open Access Journals (Sweden)

    Omar Taleb

    Full Text Available Xanthurenic acid (XA is a metabolite of the tryptophan oxidation pathway through kynurenine and 3-hydroxykynurenine. XA was until now considered as a detoxification compound and dead-end product reducing accumulation of reactive radical species. Apart from a specific role for XA in the signaling cascade resulting in gamete maturation in mosquitoes, nothing was known about its functions in other species including mammals. Based upon XA distribution, transport, accumulation and release in the rat brain, we have recently suggested that XA may potentially be involved in neurotransmission/neuromodulation, assuming that neurons presumably express specific XA receptors. Recently, it has been shown that XA could act as a positive allosteric ligand for class II metabotropic glutamate receptors. This finding reinforces the proposed signaling role of XA in brain. Our present results provide several lines of evidence in favor of the existence of specific receptors for XA in the brain. First, binding experiments combined with autoradiography and time-course analysis led to the characterization of XA binding sites in the rat brain. Second, specific kinetic and pharmacological properties exhibited by these binding sites are in favor of G-protein-coupled receptors (GPCR. Finally, in patch-clamp and calcium imaging experiments using NCB-20 cells that do not express glutamate-induced calcium signals, XA elicited specific responses involving activation of cationic channels and increases in intracellular Ca(2+ concentration. Altogether, these results suggest that XA, acting through a GPCR-induced cationic channel modulatory mechanism, may exert excitatory functions in various brain neuronal pathways.

  17. Clinical utility of rivaroxaban in stroke prevention associated with nonvalvular atrial fibrillation – patient considerations

    OpenAIRE

    Ahrens I; Bode C

    2014-01-01

    Ingo Ahrens, Christoph Bode Heart Center, University of Freiburg, Department of Cardiology and Angiology I, Freiburg, Germany Abstract: The direct factor Xa inhibitor rivaroxaban was the first within the group of orally available direct factor Xa inhibitors to gain clinical approval for oral anticoagulation in patients with nonvalvular atrial fibrillation in 2011. The –xabans, as drugs from the group of oral direct factor Xa inhibitors are often referred to, comprise currently thre...

  18. Drug: D03232 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03232 Drug Epoetin beta (genetical recombination) (JP16); Epoetin beta (USAN/INN);...er agents affecting metabolism 399 Miscellaneous 3999 Others D03232 Epoetin beta (genetical recombination) (...ONS B03XA Other antianemic preparations B03XA01 Erythropoietin D03232 Epoetin beta (genetical recombination)...:2057] [KO:K05079] Erythropoietin [ATC:B03XA01] D03232 Epoetin beta (genetical recombination) (JAN); Epoetin... factors Erythropoietin [ATC:B03XA01] D03232 Epoetin beta (genetical recombination) (JAN); Epoetin beta (USAN/INN) CAS: 122312-54-3 PubChem: 17397385 ...

  19. ¿Qué tan bien representados están los mamíferos mexicanos en la red federal de áreas naturales protegidas del país? How well represented are Mexican mammals in the natural protected area network?

    OpenAIRE

    Luis-Bernardo Vázquez; David Valenzuela-Galván

    2009-01-01

    Se evaluaron la eficiencia y eficacia de la red de áreas naturales protegidas (ANPs) federales de México para representar la riqueza de especies de mamíferos terrestres. Para determinar el porcentaje de especies no protegidas, se sobrepuso una gradilla de celdas de 0.5° x 0.5° con datos de riqueza de especies en el mapa de las ANPs y se comparó con conjuntos equivalentes de áreas seleccionados al azar. Mediante optimización se estimó cuántas celdas adicionales complementarían a las ANPs y cuá...

  20. ¿Qué tan bien representados están los mamíferos mexicanos en la red federal de áreas naturales protegidas del país? How well represented are Mexican mammals in the natural protected area network?

    Directory of Open Access Journals (Sweden)

    Luis-Bernardo Vázquez

    2009-04-01

    Full Text Available Se evaluaron la eficiencia y eficacia de la red de áreas naturales protegidas (ANPs federales de México para representar la riqueza de especies de mamíferos terrestres. Para determinar el porcentaje de especies no protegidas, se sobrepuso una gradilla de celdas de 0.5° x 0.5° con datos de riqueza de especies en el mapa de las ANPs y se comparó con conjuntos equivalentes de áreas seleccionados al azar. Mediante optimización se estimó cuántas celdas adicionales complementarían a las ANPs y cuántas áreas bastarían para proteger todas las especies al menos una vez. Los resultados indican que cerca de la quinta parte del total de especies, un tercio de las endémicas y un tercio de las vulnerables, no están protegidas. En conjuntos de celdas elegidos al azar se representan más especies que en el total de celdas cubiertas por ANPs. En la península de Baja California, la vertiente del Pacífico, la sierra Madre Occidental y el sur del país (Oaxaca se concentra el mayor número de especies no protegidas. Para complementar las celdas con ANPs se requieren 25 celdas adicionales y bastarían conjuntos óptimos de 38 celdas para representar todas las especies al menos una vez. Nuestros resultados pueden ayudar a mejorar la selección de nuevas ANPs para ganar en eficacia y eficiencia al representar a las especies de mamíferos aún no protegidas.We evaluated the efficacy and efficiency of the federal network of natural protected areas (NPAs to represent the species richness of terrestrial mammals. We overlapped a 0.5° x 0.5° grid with data on species richness with the map of NPAs, to determine the proportion of unprotected species. We compared this with equivalent sets of cells, chosen randomly. In addition, through optimization we determined how many additional cells will complement the NPAs and how many cells will represent all species at least once. We found that nearly 1/5 of the total species, 1/3 of the endemics and 1/3 of the threatened species are unprotected. The sets of cells randomly chosen represent more species than the totality of grid cells with NPAs studied. The Baja California Peninsula, Pacific Slope, the Sierra Madre Occidental, and the south of the country (Oaxaca concentrate the highest number of unprotected species. We found that to complement the grid cells with NPAs 25 additional cells are needed and that a set of 38 cells chosen optimally will be enough to represent all species at least one time. Our results can help to improve the selection of new NPAs to gain in efficacy and efficiency in the representation of still unprotected species.

  1. Análise do bem estar psicossocial de aposentados de Goiânia Análisis del bien estar psicosocial de jubilados de Goiânia Analysis of retired men’s psychosocial well-being in Goiânia

    Directory of Open Access Journals (Sweden)

    Catarino de Oliveira

    2009-12-01

    Full Text Available Este estudo analisou o bem estar psicossocial de aposentados da cidade de Goiânia. Participaram 118 homens, aposentados por tempo de serviço, cuja vida laboral ocorreu em empresas públicas, autarquias e de economia mista, de âmbito federal, estadual ou municipal. A coleta de dados foi realizada por meio de questionário com perguntas abertas e fechadas. Para a análise dos resultados foi realizada uma regressão múltipla, tendo como variável critério o índice de bem estar e, como seus possíveis preditores, oito variáveis sobre aspectos referentes aos relacionamentos sociais, vida financeira, avaliação da saúde e da vida sexual após a aposentadoria. As variáveis sobre o planejamento, satisfação com a saúde e as relações sociais nas quais eles possam se locomover com independência foram as mais significativas para o bem estar dos participantes. Esses resultados são discutidos ressaltando as especificidades da amostra aqui utilizada, as dificuldades de generalizações e a importância de futuros estudos objetivando tornar esse tema central na agenda de trabalhos sobre o envelhecimento populacional.Este estudio analizó el bienestar psicosocial en una muestra de jubilados de la ciudad de Goiânia. Participaron 118 hombres, jubilados tras finalizar su vida laboral, cuyo trabajo transcurrió en empresas públicas y de economía mixta, de ámbito nacional, comarcal o municipal. La recogida de datos fue realizada por medio de la aplicación de un cuestionario con preguntas abiertas y cerradas. Para la obtención de los resultados fue realizado un análisis de regresión múltiple, en el que la variable criterio fue el índice de bienestar y como variables predictoras se incluyeron ocho variables acerca de aspectos referidos a las relaciones sociales, situación económica, evaluación de la salud y de la vida sexual después de la jubilación. Las variables eferidas a la planificación, la satisfacción con la vida y las relaciones sociales que permiten desplazarse con independencia fueron las más significativas en la explicación del bienestar de los participantes. En la discusión de los resultados obtenidos se destaca la especificidad de la muestra utilizada, las dificulatades para poder generalizar los resultados y la necesidad de realizar futuras investigaciones que tengan como objetivo el estudio del envejecimiento poblacional.This study examined the psychosocial well-being of retired on pension men in Goiânia. The participants were 118 men, retired by service time, whose working life occurred in public service companies. The instrument used was a questionnaire with open and closed questions. Multiple regressions were used to analyze the data. The dependent variable was the well being index and the predictors were eight variables on aspects related to social relationships, financial life, health and sexual life after retirement. The most significant predictors for the well being of the participant were living the retirement as planned, satisfaction with their health and the possibility of social relationships where they can move more independently. These results are discussed emphasizing the peculiarities of the sample, the difficulties to generalize the results and the importance of further studies aiming at making the subject central to agenda of studies on population aging.

  2. Comprometimento, bem-estar e satisfação dos professores de administração de uma universidade federal Comprometimiento organizacional, bien estar y satisfacción en el trabajo de los profesores de administración de una universidad federal Commitment, well-being and satisfaction of management professors at a federal university

    OpenAIRE

    Maria Teodora Farias Traldi; Gisela Demo

    2012-01-01

    As pesquisas sobre o comprometimento organizacional, o bem-estar e a satisfação no trabalho vêm sendo realizadas com êxito na área de Psicologia Organizacional. Novos estudos sinalizam uma possível interdependência entre estes construtos. O objetivo precípuo desta pesquisa foi investigar as relações entre comprometimento organizacional, bem-estar e satisfação no trabalho, através de um censo realizado com os 104 professores de Administração de uma Universidade Federal, com taxa de resposta de...

  3. "Allo Berkeley ? Ici Lyon… Vous nous voyez bien ?" Étude d'un dispositif de formation en ligne synchrone franco-américain à travers les discours de ses usagers Study of a synchronous online language learning programme: the impact of videoconferencing and synchronicity on learners and tutor trainees

    Directory of Open Access Journals (Sweden)

    Richard Kern

    2008-12-01

    Full Text Available Cet article se donne comme objectif d'étudier l'impact de la multimodalité et de la synchronie sur la communication pédagogique en ligne à travers le discours des usagers d'une formation en ligne synchrone. Celle-ci s'est déroulée en 2007 et, dans le cadre d'un dispositif d'enseignement / apprentissage en ligne synchrone, a mis en relation des dyades d'étudiants de master professionnel de l'université de Lyon 2 et des dyades d'étudiants de français de l'université de Californie de Berkeley via une plateforme de visioconférence poste à poste. Après avoir présenté le dispositif pédagogique, nous chercherons, à partir d'entretiens effectués auprès des deux catégories de participants (apprentis tuteurs et apprenants, à rendre compte de l'empan des représentations associées à une même pratique d'un dispositif d'enseignement / apprentissage en ligne : les types d'utilisation des modalités (écrit, oral, visuel par les participants, les effets psycho-affectifs liés à une situation d'échange multimodal synchrone et, enfin, les compétences développées dans ce dispositif. L'analyse des deux corpus (français et américain montre une appropriation progressive de la communication à travers ce dispositif par les usagers, ainsi que le développement de compétences spécifiques : du côté des apprenants américains, une amélioration au niveau de l'aisance dans la prise de parole, du côté des apprentis tuteurs français une appropriation de gestes professionnels liés à l'écoute et à la spontanéité dans la relation pédagogique.This article studies the impact of multimodality and synchronicity on an online teaching/learning exchange between dyads of Masters degree students in teaching French as a foreign language at the University of Lyon 2 and dyads of intermediate-level French students at the University of California, Berkeley during the 2006-07 academic year. The desktop videoconferencing platform allowed face-to-face audiovisual communication as well as synchronous written chat. Based on observational and interview data, the study explores how participants use speech, writing, and visual contact online, the affective effects of these uses, and the types of competences developed as a consequence. Analysis of the two corpora (French and American shows a progressive adaptation to the particularities of desktop videoconferencing and the development of specific competencies: among the American learners of French, greater confidence and ease in taking the floor; among the French teachers-in-training, development of a professional online persona and flexibility in their pedagogical stance and strategies.

  4. Equivalence of Product Tax Changes and Public Enterprise Price Changes (L'équivalence entre la modification des taxes sur les produits et le relèvement des prix des entreprises publiques) (Equivalencia de las modificaciones de los impuestos sobre bienes y las modificaciones de los precios de empresas públicas)

    OpenAIRE

    Robert H. Floyd

    1981-01-01

    This paper analyzes, in a variety of partial and general equilibrium settings, the effects on both resource mobilization and allocation of (a) an increase in nonfinancial public enterprises' prices and (b) the application of a tax to certain transactions and/or enterprises. It is often assumed that if nonfinancial public enterprises are operated efficiently, pricing policies and practices that would result in the generation of operating surpluses (or losses) may be regarded as equivalent in s...

  5. Centralización o descentralización; gestión pública o privada de un “bien escaso”: historiografía sobre el agua en la ciudad de México en los siglos XIX y XX

    Directory of Open Access Journals (Sweden)

    Simón Ruiz, Inmaculada

    2007-12-01

    Full Text Available Essay about the management of the water in Mexico City during XIX and XX centuries. It reviews the most significant titles from the Porfiriato to our days with special interest in the most recent bibliography in the discussion around the paper that must have the State and the local governments in the control of the water. It treats to respond to the question if the water must be considered like merchandise or a human right, using the arguments of the defenders of one and the other idea.

    Ensayo historiográfico en torno a la gestión del agua en la ciudad de México en los siglos XIX y XX. Se revisan los títulos más significativos desde el Porfiriato a nuestros días, con especial interés en la bibliografía más reciente centrada en la discusión en torno al papel que deben tener el Estado y los gobiernos locales en el control y organización de la distribución de ese líquido tan necesario. Se trata de responder a la pregunta de si el agua debe ser considerada como mercancía o como derecho, utilizando los argumentos de los defensores de una y otra idea.

  6. Movilidad, redes de intercambio y circulación de bienes en el sudoeste del Neuquén (Norpatagonia, Argentina: Los moluscos marinos del lago Traful Mobility, Exchange Networks And Circulation Of Goods In Southwestern Neuquén, Northern Patagonia, Argentina: The Marine Mollusks From Traful Lake

    Directory of Open Access Journals (Sweden)

    Mario Silveira

    2010-12-01

    Full Text Available Se determina la procedencia de fragmentos de moluscos marinos hallados en los aleros Los Cipreses y Lariviere, en el área del lago Traful, sur de la provincia de Neuquén. Estudios previos en áreas cercanas con mayor proximidad a la costa del océano Pacífico suponen que las piezas recuperadas evidencian contacto con grupos provenientes del lado occidental de la cordillera de Los Andes -Chile. En este trabajo se indica que parte de las valvas estudiadas corresponden a fósiles marinos o fluviales no identificados. Los fragmentos identificados corresponden al gasterópodo marino Adelomelon brasiliana procedente del Atlántico y al bivalvo Choromytilus chorus posiblemente del Pacífico. Estos datos, sumados a los recientes análisis sobre muestras de obsidiana procedentes de fuentes de aprovisionamiento del sudoeste neuquino que circularon grandes distancias hacia la costa atlántica, resaltan la complejidad y extensión de la movilidad humana y/o de las redes interregionales de intercambios.In this article the origin of fragments of marine shells found at Los Cipreses and Lariviere rock-shelters is presented. Consistent with studies by other authors in nearby areas in greater proximity to the Pacific coast, it was assumed that these fragments indicated contact with groups from the western side of the Chilean Andes. The results show that the shells correspond to marine or unknown fluvial fossils; a few pieces correspond to a marine gasteropod of great size, Adelomelon brasiliana, from the Atlantic Ocean and the bivalve Choromytilus chorus, probably from the Pacific. These data, and the recent analysis of samples of obsidian from sources located in southwestern Neuquén, which circulated far toward the Atlantic coast, highlight the complexity and extent of human mobility and interregional exchange networks.

  7. Una teoría de la argumentación jurídico-penal: un primer esbozo sobre el ejemplo del bien jurídico protegido en el art. 318 bis del Código Penal español

    OpenAIRE

    Sánchez Lázaro, Fernando Guanarteme

    2008-01-01

    El desarrollo de teorías de la argumentación jurídica, en el seno de la teoría general del Derecho, viene ofreciendo interesantes materiales para una racionalización del discurso jurídico. Sin embargo, la complejidad de lo jurídico precisa de mayores márgenes de rendimiento y con ello, probablemente también, de especialización. En las siguientes páginas se ofrece un primer esbozo de una —por el momento, tan sólo— posible teoría de la argumentación jurídico-penal.

  8. Avance en el tratamiento de la información de bienes culturales adscritos al patrimonio histórico industrial para su implementación en administraciones, museos o centros de interpretación interactivos mediante el empleo de las nuevas técnicas gráficas y de análisis

    OpenAIRE

    Castro García, Miguel

    2013-01-01

    La presente Tesis Doctoral desarrolla desde la ingeniería gráfica nuevas metodologías para obtener resultados en el tratamiento de la información del patrimonio histórico industrial que permitan su puesta en valor, en especial de los eólicos y oleícolas, y su implementación para su difusión por parte de las administraciones públicas, museos y centros de interpretación interactivos. Para ello, la estructura de la misma se plasma en los siguientes capítulos: El Capítulo 1 revi...

  9. Qualidade de vida e bem-estar espiritual em pacientes com doença pulmonar obstrutiva crônica Calidad de vida y bien estar espiritual en pacientes con enfermedad pulmonar obstructiva crónica Quality of life and spiritual well-being in chronic obstructive pulmonary disease patients

    Directory of Open Access Journals (Sweden)

    Maíra Shiramizu da Silva

    2009-12-01

    Full Text Available Este estudo teve como objetivos avaliar a qualidade de vida relacionada à saúde (QVRS e o bem-estar espiritual (BEE de pacientes com doença pulmonar obstrutiva crônica (DPOC e analisar as relações entre QVRS e BEE. As versões em português do Seattle Obstructive Lung Disease Questionnaire (SOLDQ e do Spiritual Well-Being Scale (SWBS foram aplicadas por entrevista a 70 pacientes com DPOC em tratamento ambulatorial. Os domínios do SOLDQ com menor e maior escores foram: Função Física (37,29±17,19 e Satisfação com o Tratamento (68,75±28,05. O escore médio de 94,87±13,56 indica um nível moderado de BEE. O escore total do SWBS e o da subescala Bem-Estar Religioso correlacionaram-se positivamente com o domínio Satisfação com o Tratamento (p=0,007 e p=0,002, respectivamente. Correlação negativa foi encontrada entre Bem-Estar Religioso e Função Física (p=0,05. Pacientes com maior bem-estar religioso estavam mais satisfeitos com o tratamento e tinham pior funcionamento físico.En este estudio se evaluaron la calidad de vida relacionada con la salud (CVRS y el bienestar espiritual (BEE de pacientes con enfermedad pulmonar obstructiva crónica (EPOC y además la relación entre la CVRS y BEE. Setenta pacientes con EPOC en tratamiento ambulatorial fuerón entrevistados usando las versiones en portugués del Seattle Obstructive Lung Disease Questionnaire (SOLDQ y del Spiritual Well-Being Scale (SWBS. Las dimensiones del SOLDQ con puntuaciones más bajos y más altos fueron: Función Física (37,29 ± 17,19 y Satisfacción con el Tratamiento (68,75 ± 28,05. La puntuación media 94,87 ± 13,56 indica un nivel moderado de BEE. La puntuación total del Bienestar Religioso correlacionó positivamente con la Satisfacción con el Tratamiento (p = 0,007 y p = 0,002, respectivamente. Se encontró correlación negativa entre bienestar religioso y función físico (p = 0,05. Los pacientes con mayor bienestar religioso estaban más satisfechos con el tratamiento y tenían peor función físico.This study aimed to evaluate health related quality of life (HRQL and spiritual well-being (SWB of patients with chronic obstructive pulmonary disease (COPD and to investigate the relationship between HRQOL and SWB. Seventy outpatients with COPD were interviewed using Portuguese versions of the Seattle Obstructive Lung Disease Questionnaire (SOLDQ and Spiritual Well-Being Scale (SWBS. SOLDQ domains with lowest and highest scores were Physical Function (37.29±17.19 and Treatment Satisfaction (68.75±28.05. Total score of the SWBS was 94.87±13.56, indicating a moderate level of SWB. Total SWB and the subscale Religious Well-Being correlate positively with Treatment Satisfaction (p=0.007 and p=0.002, respectively. Negative correlation were found between Religious Well-Being and Physical Function domain (r = -0.233, p=0.05. Patients with higher spiritual/religious well-being were more satisfied with treatment and had worst physical functioning.

  10. LOS OBISPOS DE LA PROVINCIA ECLESIÁSTICA DE ECUADOR Y LA CODIFICACIÓN DEL DERECHO CANÓNICO DE 1917: LOS "POSTULATA EPISCOPORUM" ACERCA DE LOS BIENES ESPIRITUALES Y TEMPORALES BlSHOPS CHURCH OF THE PROVINCE OF ECUADOR AND THE CODIFICATION OF CANON LAW OF 1917: THE "POSTULATA EPISCOPORUM" ABOUT THE SPIRITUAL AND TEMPORAL GOODS

    OpenAIRE

    Carlos Salinas Araneda

    2011-01-01

    La redacción del primer Código de Derecho Canónico que tuvo la Iglesia latina fue ordenada por el papa san Pío X en 1904. La tarea codificadora, empero, no fue obra de un grupo cerrado de expertos, sino que tuvo en cuenta el parecer del episcopado latino, el que fue consultado en dos momentos diferentes; en ambos fueron consultados los obispos de Ecuador. En este trabajo se estudia, a partir de la documentación guardada en el Archivo Secreto Vaticano, el aporte de los obispos ecuatorianos en ...

  11. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado What is the Contribution of Executive Dysfunction to the Cognitive Profile of Bipolar Disorder? A Well-Controlled Direct Comparison Study

    OpenAIRE

    Juan Lopera-Vasquez; Vaughan Bell; Carlos López-Jaramillo

    2011-01-01

    Background: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistical variance attributed to primary executive function deficits. This study tests the hypothesis that verbal memory deficits in bipolar patients are largely the result of executive difficulties by ...

  12. La qualité bien rare de Sâlih Ibn Yahyâ parmi les historiens orientaux au Moyen Âge: Écrire l'histoire des émirs Buhtur en utilisant les archives familiales

    Directory of Open Access Journals (Sweden)

    Pierre Moukarzel

    2012-01-01

    Full Text Available Sâlih Ibn Yahyâ, à la différence des chroniqueurs du xive et du xve siècle, a consacré son œuvre à écrire l’histoire de sa famille. Cet ouvrage est très important car il est fondé dans sa plus grande partie sur des archives familiales conservées par les émirs Buhtur qui ont régné sur une région du Mont Liban appelée al-Gharb.Ces archives comprennent des pièces officielles, des lettres patentes, des acts d’iqṭâ‛, des décrets, des ordres, que les émirs Buhtur ont reçus, soit de la cour d’Égypte, soit de celle de Damas, soit encore des Mongols ou des Francs.Ces pièces d’archives couvrent une période allant du xiie jusqu’au xive siècle. Leur présentation et leur analyse fournissent des informations très intéressantes sur l’usage et les règles de la rédaction dans les chancelleries des sultans zinghîdes, ayyûbîdes et des premiers sultans mamelouks.

  13. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement

    DEFF Research Database (Denmark)

    Lassen, Michael Rud; Gallus, Alexander; Raskob, Gary E;

    2010-01-01

    There are various regimens for thromboprophylaxis after hip replacement. Low-molecular-weight heparins such as enoxaparin predominantly inhibit factor Xa but also inhibit thrombin to some degree. Orally active, specific factor Xa inhibitors such as apixaban may provide effective thromboprophylaxi...

  14. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice

    Institute of Scientific and Technical Information of China (English)

    Jiao Wu; Haichuan Yu; Haofu Dai; Wenli Mei; Xin Huang; Shuifang Zhu; Ming Peng

    2012-01-01

    The metabolic changes of bacterial blight-resistant line C418/Xa23 generated by molecular marker-assisted selection (n =12),transgenic variety C418-Xa21 generated by using the Agrobacterium-mediated system (n =12),and progenitor cultivar C418 (n =12) were monitored using gas chromatography/mass spectrometry.The validation,discrimination,and establishment of correlative relationships between metabolite signals were performed by cluster analysis,principal component analysis,and partial least squares-discriminant analysis.Significant and unintended changes were observed in 154 components in C418/Xa23 and 48 components in C418-Xa21 compared with C418 (P < 0.05,Fold change > 2.0).The most significant decreases detected (P< 0.001) in both C418/Xa23 and C418-Xa21 were in three amino acids: glycine,tyrosine,and alanine,and four identified metabolites: malic acid,ferulic acid,succinic acid,and glycerol.Linoleic acid was increased specifically in C418/Xa23 which was derived from traditional breeding.This line,possessing a distinctive metabolite profile as a positive control,shows more differences vs.the parental than the transgenic line.Only succinic acid that falls outside the boundaries of natural variability between the two non-transgenic varieties C418 and C418/Xa23 should be further investigated with respect to safety or nutritional impact.

  15. Modules over Double Crossproducts of Skew-Hopf Pairs

    Institute of Scientific and Technical Information of China (English)

    潘庆年; 郝志峰

    2002-01-01

    The purpose is to study modules of double crossproducts D( X, A ) of Skew-Hopf pairs (X,A). A sufficient and necessary condition for M to be D( X,A )-mod is shown. Relations between D( X, A ) -mod and quantam Yang-Baxter A-mod or X-mod are revealed.

  16. Rivaroxaban in patients with a recent acute coronary syndrome

    DEFF Research Database (Denmark)

    Mega, Jessica L; Braunwald, Eugene; Wiviott, Stephen D; Bassand, Jean-Pierre; Bhatt, Deepak L; Bode, Christoph; Burton, Paul; Cohen, Marc; Cook-Bruns, Nancy; Fox, Keith A A; Goto, Shinya; Murphy, Sabina A; Plotnikov, Alexei N; Schneider, David; Sun, Xiang; Verheugt, Freek W A; Gibson, C Michael; Grande, Peer

    2012-01-01

    Acute coronary syndromes arise from coronary atherosclerosis with superimposed thrombosis. Since factor Xa plays a central role in thrombosis, the inhibition of factor Xa with low-dose rivaroxaban might improve cardiovascular outcomes in patients with a recent acute coronary syndrome....

  17. Drug: D01779 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01779 Drug Sodium acetate hydrate (JP16); Sodium acetate (USP); Sodium acetate trihydr... ADDITIVES B05XA Electrolyte solutions B05XA08 Sodium acetate D01779 Sodium acetate hydrate (JP16); Sodium acetate (USP) USP dr...neral Replacement Sodium D01779 Sodium acetate hydrate (JP16); Sodium acetate (US

  18. Jalaväebrigaad sai 18 Sisu soomukit

    Index Scriptorium Estoniae

    2014-01-01

    1. jalaväebrigaad sai kätte viis Afganistanis kasutusel olnud soomukit Sisu XA-180 ning kolmteist Hollandist hangitud soomukit Sisu XA-188. 1. jalaväebrigaad on kaitseväe põhimanööverüksus, mis riigikaitse arengukava kohaselt muutub lähitulevikus soomusbrigaadiks

  19. Dicty_cDB: FC-BI13 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available pisum, Pea Aphid Acyrthosiphon pisum cDNA clone WHAP-002_A12 5', mRNA sequence. 50 3e-04 2 CD036313 |CD036313.1 mgmt...015xA07f.b Mated culture Magnaporthe grisea cDNA clone mgmt015xA07 5', mR

  20. Dicty_cDB: SSD216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SEQUENCE, 13 unordered pieces. 52 0.008 1 CD035209 |CD035209.1 mgmt019xA08f.b Ma...ted culture Magnaporthe grisea cDNA clone mgmt019xA08 5', mRNA sequence. 52 0.008 1 AF160643 |AF160643.2 D02

  1. Dicty_cDB: SFJ609 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2 CD036313 |CD036313.1 mgmt015xA07f.b Mated culture Magnaporthe grisea cDNA clone mgmt015xA07 5', mRNA seque...ea Aphid Acyrthosiphon pisum cDNA clone WHAP-002_A12 5', mRNA sequence. 50 3e-04

  2. Dicty_cDB: SHJ401 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available bidopsis thaliana cDNA clone 1161972 5', mRNAsequence. 42 0.097 2 CD036035 |CD036035.1 mgmt...004xA15f.b Mated culture Magnaporthe grisea cDNA clone mgmt004xA15 5', mRNA sequence. 46 1.0 1 AC1

  3. Helium effects on tungsten surface morphology and deuterium retention

    NARCIS (Netherlands)

    Ueda, Y.; H. Y. Peng,; H. T. Lee,; N. Ohno,; S. Kajita,; Yoshida, N.; Doerner, R.; De Temmerman, G.; V. Alimov,; G. Wright,

    2013-01-01

    Recent experimental results on tungsten surface morphology, especially nano-structure (fuzz), induced by helium plasma exposure at temperatures between 1000&#xa0;K and 2000&#xa0;K are reviewed. This structure was firstly reported in 2006. In this review, most of experimental results reported

  4. Drug: D02323 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A10 DRUGS USED IN DIABETES... A10X OTHER DRUGS USED IN DIABETES A10XA Aldose reductase inhibitors A10XA01 Tolrestat D02323 T

  5. Xanthium italicum, Xanthium strumarium and Arctium lappa as new hosts for Diaporthe helianthi.

    Science.gov (United States)

    Vrandecic, Karolina; Jurkovic, Drazenka; Riccioni, Luca; Cosic, Jasenka; Duvnjak, Tomislav

    2010-07-01

    Sunflower (Helianthus annuus) stem canker caused by Diaporthe helianthi is one of the most important sunflower diseases in Croatia. Until recently, sunflower was the only known host for D. helianthi. In our research carried out in the area of Eastern Croatia, isolates of Diaporthe/Phomospis were collected from Xanthium italicum, X. strumarium and Arctium lappa. Using morphological, cultural and molecular ITS rDNA data, isolates from these weeds were identified as D. helianthi. The following isolates were used in the pathogenicity test: one isolate originated from sunflower (Su5/04), three from X. italicum (Xa2, Xa3 and Xa5), two from X. strumarium (Xa9 and Xa12), one from Xanthium sp. (Xa13) and one from A. lappa (Ar3). According to the results, it was determined that isolate Xa5 (originated from X. italicum) was the most pathogenic to sunflower stems. The average length of the lesion was 11.3 cm. The lowest level of pathogenicity was found in Xa9 (isolated from X. strumarium). The length of the lesion was 0.1 cm. PMID:20182800

  6. Genus four superstring measures

    OpenAIRE

    Cacciatori, Sergio L.; Piazza, Francesco Dalla; Geemen, Bert van

    2008-01-01

    A main issue in superstring theory are the superstring measures. D'Hoker and Phong showed that for genus two these reduce to measures on the moduli space of curves which are determined by modular forms of weight eight and the bosonic measure. They also suggested a generalisation to higher genus. We showed that their approach works, with a minor modification, in genus three and we announced a positive result also in genus four. Here we give the modular form in genus four explicitly. Recently S...

  7. Farmland acquisition and livelihood choices of households in Hanoi’s peri-urban areas

    OpenAIRE

    Tran Tuyen; Lim, Steven

    2011-01-01

    The relation between land and rural livelihood has been a topic of interest for many researchers and development practitioners. In the context of rising farmland loss due to the escalated urbanization and industrialization in Vietnam’s developed provinces, several researchers have tried to address how farm households respond to farmland loss in peri-urban areas (e.g., Do, 2006 ;Ngo, 2009 ;S.V.Nguyen, 2009 ;Phong, 2007 ;Vo, 2006).However, no studies have quantified the impacts of farmland loss...

  8. Lighting effects rendering in three-dimensional computer-generated holographic display

    Science.gov (United States)

    Zhang, Hao; Cao, Liangcai; Jin, Guofan

    2016-07-01

    We present a technique for generating three-dimensional (3-D) computer-generated holograms (CGHs) with realistic lighting effects based on a phase-only spatial light modulator (SLM). Phong reflection model is employed in the calculation of reflectance distribution for CGH synthesizing. Directional point-based algorithm produces realistic lighting effects of the 3-D scenes in processing the ambient, diffuse and specular reflections. A phase-only SLM is used to perform the optical experiments, and the results show that the proposed technique can perform quality reconstructions of the 3-D scenes with high optical efficiency and efficient utilization of the system space-bandwidth product.

  9. Abnormal X : autosome ratio, but normal X chromosome inactivation in human triploid cultures

    Directory of Open Access Journals (Sweden)

    Norwood Thomas H

    2006-07-01

    Full Text Available Abstract Background X chromosome inactivation (XCI is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi in normal female cells, leaving them with a single active X (Xa as in male cells. In cells with more than two X's, but a diploid autosomal complement, all X's but one, Xa, are inactivated. This phenomenon is commonly thought to suggest 1 that normal development requires a ratio of one Xa per diploid autosomal set, and 2 that an early event in XCI is the marking of one X to be active, with remaining X's becoming inactivated by default. Results Triploids provide a test of these ideas because the ratio of one Xa per diploid autosomal set cannot be achieved, yet this abnormal ratio should not necessarily affect the one-Xa choice mechanism for XCI. Previous studies of XCI patterns in murine triploids support the single-Xa model, but human triploids mostly have two-Xa cells, whether they are XXX or XXY. The XCI patterns we observe in fibroblast cultures from different XXX human triploids suggest that the two-Xa pattern of XCI is selected for, and may have resulted from rare segregation errors or Xi reactivation. Conclusion The initial X inactivation pattern in human triploids, therefore, is likely to resemble the pattern that predominates in murine triploids, i.e., a single Xa, with the remaining X's inactive. Furthermore, our studies of XIST RNA accumulation and promoter methylation suggest that the basic features of XCI are normal in triploids despite the abnormal X:autosome ratio.

  10. Drug: D03231 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03231 Drug Epoetin alfa (genetical recombination) (JP16); Epoetin alfa (USAN/INN);...gents affecting metabolism 39 Other agents affecting metabolism 399 Miscellaneous 3999 Others D03231 Epoetin alfa (genetica...S B03X OTHER ANTIANEMIC PREPARATIONS B03XA Other antianemic preparations B03XA01 Erythropoietin D03231 Epoetin alfa (genetica...Products/Modifiers/Volume Expanders Blood Formation Modifiers Epoetin alfa D03231 Epoetin alfa (genetical re...eceptor [HSA:2057] [KO:K05079] Erythropoietin [ATC:B03XA01] D03231 Epoetin alfa (genetical recombination) (J

  11. Drug: D03339 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ng individual organs 23 Digestive organ agents 231 Antidiarrheals, intestinal regulators 2312 Tannic acids...FLAMMATORY/ANTIINFECTIVE AGENTS A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA01 Albumin tannate D03339 Albumin tan... of Albumin with Tannic acid [DR:D01959] Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecti...D03339 Drug Albumin tannate (JP16); Tannalbin (TN) Therapeutic category: 2312 ATC code: A07XA01 Component... D03339 Albumin tannate (JP16) Anatomical Therapeutic Chemical (ATC) classificati

  12. Avaliação comparativa das propriedades de xantanas produzidas pelo patovar pruni e clairana com xantana comercial para predição de uso Comparative evaluation of xanthans properties produced by pathovar pruni and clairana with commercial xanthan to predict their uses

    Directory of Open Access Journals (Sweden)

    Patrícia D. Oliveira

    2013-01-01

    Full Text Available O presente trabalho teve como objetivo determinar a adequabilidade de três amostras de biopolímero xantana (Xa 06, Xa 82 e Xa 106 e uma clairana como viscosificantes de fluidos de perfuração de poços de petróleo, comparando com uma amostra de xantana comercial, Xanvis®. Foram realizadas análises reológicas, determinados os conteúdos de acetil, piruvato e íons Na+ K+ e Ca2+, e avaliada a capacidade viscosificante segundo norma específica da Petrobras. Os conteúdos de grupos acetil e piruvato para as xantanas e clairana diferiram significativamente entre si, mas foram compatíveis com valores preconizados ou citados na literatura concernente. Com relação ao conteúdo de íons, a xantana comercial apresentou quantidade de cálcio superior, as amostras Xa 06, Xa 82 e Xa 106 tiveram maior teor de potássio e a clairana maior teor de sódio. A viscosidade e a viscoelasticidade da amostra de xantana comercial foram superiores às demais amostras analisadas. Na análise como viscosificante para fluidos de perfuração as amostras de xantana comercial e Xa 106 atingiram os requisitos estabelecidos para os parâmetros n, K e força gel da norma Petrobras N-2605. Com a interpretação conjunta dos resultados obtidos pode-se inferir que apenas as xantanas Xanvis® e Xa 106 apresentam características adequadas à utilização como viscosificante em fluido de perfuração de petróleo. As demais amostras possuem características reológicas adequadas à utilização como espessantes ou estabilizantes em outros segmentos industriais, como em alimentos, tintas e cosméticos.The aim of this study was to determine the suitability of three xanthans (Xa 06, Xa 82 and Xa 106 and a clairana biopolymer for use as drilling fluid thickeners and comparing them against a commercial sample, Xanvis®. Rheological analyses were performed to determine the acetyl, pyruvate and Na+ K+ and Ca2+ ion content and their thickening ability, according to Petrobras

  13. RUBY-1

    DEFF Research Database (Denmark)

    Steg, Ph Gabriel; Mehta, Shamir R; Jukema, J Wouter;

    2011-01-01

    To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS)....

  14. 76 FR 19748 - Atlantic Coastal Fisheries Cooperative Management Act Provisions; General Provisions for Domestic...

    Science.gov (United States)

    2011-04-08

    ... National Oceanic and Atmospheric Administration RIN 0648-XA312 Atlantic Coastal Fisheries Cooperative Management Act Provisions; General Provisions for Domestic Fisheries; Application for Exempted Fishing...-50 mm carapace length), throughout lobster management area 3 (Area 3), in an attempt to...

  15. 76 FR 41764 - Atlantic Coastal Fisheries Cooperative Management Act Provisions; General Provisions for Domestic...

    Science.gov (United States)

    2011-07-15

    ... National Oceanic and Atmospheric Administration RIN 0648-XA563 Atlantic Coastal Fisheries Cooperative Management Act Provisions; General Provisions for Domestic Fisheries; Application for Exempted Fishing... population in management Area 3. This EFP would excuse 11 commercial fishing vessels from the...

  16. Drug: D04032 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 3) Peptide Treatment of anemia associated with chronic renal failure ATC code: B03XA01 erythropoietin...ors Class I cytokine receptors (hematopoietin family receptors) erythropoietin re

  17. 重组人甲状旁腺激素相关蛋白1-141序列的克隆和表达载体构建%Cloning and Construction for Expression Vector of Recombinant Human Parathyroid Hormone Related Protein 1-141 Sequence

    Institute of Scientific and Technical Information of China (English)

    刘新宇; 梁东春; 左爱军; 张镜宇; 郭刚

    2006-01-01

    目的:构建人甲状旁腺激素相关蛋白1-141(hPTHrP1-141)基因的表达载体.方法:提取人基因组DNA,PCR扩增PTHrP1-141基因,将其克隆人原核表达载体pQE-30Xa,构建重组表达载体pQE-30Xa/hPTHrP1-141.结果:重组载体pQE-30Xa/hPTHrP1-141经限制性核酸内切酶PvuⅡ酶切鉴定,得到符合预期大小的核酸片段.结论:表达载体pQE-30Xa/hPTHrP1-141构建成功.

  18. Drug: D02796 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02796 Drug Albumin iodinated I 131 serum (USAN); Megatope (TN) Diagnostic aid [blo...od volume determination]; Diagnostic aid [intrathecal imaging]; Radioactive agent ATC code: V09XA03 Anatomic

  19. 76 FR 75523 - Vessel Monitoring Systems; Approved Mobile Transmitting Units and Communications Service...

    Science.gov (United States)

    2011-12-02

    ... National Oceanic and Atmospheric Administration RIN 0648-XA844 Vessel Monitoring Systems; Approved Mobile... (NOAA), Commerce. ACTION: Notice of vessel monitoring systems; type approval. SUMMARY: This document provides notice that three mobile transmitting unit (MTU) vessel monitoring systems (VMS) that...

  20. 76 FR 53413 - South Atlantic Fishery Management Council Meeting

    Science.gov (United States)

    2011-08-26

    ... Enforcement Committee; Ecosystem-Based Management Committee; Executive/ Finance Committees; King and Spanish... National Oceanic and Atmospheric Administration RIN 0648-XA660 South Atlantic Fishery Management Council... (NOAA), Commerce. ACTION: Notice of public meeting of the South Atlantic Fishery Management...

  1. Drug: D10291 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10291 Mixture, Drug Aliskiren hemifumarate - amlodipine besylate - hydrochlorothiazide mixt; Am ... 615], Hydrochlorothiazide [DR:D00340] Treatment of hypertension ... ATC code: C09XA54 Anatomical Therapeutic Chemical ...

  2. Drug: D10290 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10290 Mixture, Drug Aliskiren hemifumarate - amlodipine besylate mixt; Tekamulo (TN) Aliskiren ... 412], Amlodipine besilate [DR:D00615] Treatment of hypertension ... ATC code: C09XA53 Anatomical Therapeutic Chemical ...

  3. Drug: D10289 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10289 Mixture, Drug Aliskiren hemifumarate - hydrochlorothiazide mixt; Tekturna hct (TN) Aliski ... 412], Hydrochlorothiazide [DR:D00340] Treatment of hypertension ... ATC code: C09XA52 Anatomical Therapeutic Chemical ...

  4. 76 FR 64073 - New England Fishery Management Council; Public Meetings

    Science.gov (United States)

    2011-10-17

    ... locations, see SUPPLEMENTARY INFORMATION. Council address: New England Fishery Management Council, 50 Water... National Oceanic and Atmospheric Administration RIN 0648-XA763 New England Fishery Management Council... Council's (Council) Groundfish Advisory Panel, Recreational Advisory Panel and Groundfish...

  5. Disease: H01151 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available infections in patients with underlying diseases. Infectious disease Brevundimonas vesicularis Brevundimonas...d-stage renal disease Autoimmune diseases Vancomycin [ATC: J01XA01] Ceftazidime [ATC:J01DD02] Levofloxacin [

  6. A randomized, open-label trial of edoxaban in Japanese patients with severe renal impairment undergoing lower-limb orthopedic surgery

    OpenAIRE

    Fuji, Takeshi; Fujita, Satoru; Kawai, Yohko; Abe, Yasuyuki; Kimura, Tetsuya; Fukuzawa, Masayuki; Abe, Kenji; Tachibana, Shintaro

    2015-01-01

    Background Edoxaban is an oral, direct, factor Xa inhibitor approved in Japan for thromboembolic prophylaxis after lower-limb orthopedic surgery (LLOS), but contraindicated in patients with severe renal impairment (SRI; creatinine clearance [CLCR] ≥15 to

  7. Application of basic and composite thrombelastography parameters in monitoring of the antithrombotic effect of the low molecular weight heparin dalteparin: an in vivo study

    DEFF Research Database (Denmark)

    Artang, Ramin; Frandsen, Niels J; Nielsen, Jørn Dalsgaard

    2009-01-01

    for plasma levels of antiXa in the therapeutic range of 0.5 - 1.0 U/ml were calculated. RESULTS: All basic TEG parameters correlated significantly with antiXa levels. Among the basic parameters, the TEG reaction time R had the best correlation with antiXa levels with the most favorable combination of...... basic parameters (r = - 0.87, p < 0.0001, sensitivity 95%, specificity 79%). CONCLUSION: The TEG reaction time R and TDR are the most suitable TEG parameters for evaluation of the antithrombotic effect of dalteparin with a highly significant correlation with antiXa levels in healthy male volunteers....... Measures for uniform clinical use of these parameters are proposed. Larger clinical trials are needed to correlate R and TDR with clinical outcomes....

  8. Drug: D10000 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available A CRTGD (Disulfide bridge:7-161, 29-33) Peptide ATC code: B03XA01 See erythropoietin... [CPD:C18200] [hsa:2056] [KO:K05437] erythropoietin receptor agonist [HSA:2057] [KO:K05079] hsa04060(2057...oietin family receptors) erythropoietin receptor [HSA:2057] [KO:K05079] Erythropoietin [ATC:B03XA01] D10000

  9. Drug: D04834 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04834 Drug Magnesium ... chloride (JAN/USP) MgCl2. 6H2O 201.9861 203.3027 D04834.gif Replenisher [e ... L SUPPLEMENTS A12C OTHER MINERAL SUPPLEMENTS A12CC Magnesium ... A12CC01 Magnesium ... chloride D04834 Magnesium ... chlori ... TION ADDITIVES B05XA Electrolyte solutions B05XA11 Magnesium ... chloride D04834 Magnesium ... chloride (JAN/USP) USP d ...

  10. Conflicto, paz e intervención internacional

    Directory of Open Access Journals (Sweden)

    Alfredo Molano

    2000-09-01

    Full Text Available Nuestro conflicto armado nunca ha estado desvinculado del contexto internacional, bien como presencia activa de terceros, o bien como pretexto y expediente para legitimar a una de las partes y desligitimar a la otra.

  11. How to use unfractionated heparin to treat neonatal thrombosis in clinical practice.

    Science.gov (United States)

    Bhatt, Mihir D; Paes, Bosco A; Chan, Anthony K

    2016-09-01

    Among children, neonates have the highest incidence of thrombosis due to risk factors such as catheter instrumentation, an evolving coagulation system and congenital heart disease. Unfractionated heparin (UFH) is one of the most commonly used anticoagulants in neonates. Published guidelines delineate dosing and monitoring protocols for UFH therapy in newborns. However, challenging clinical situations frequently present that warrants healthcare providers to think critically beyond the range of guidelines, and judiciously resolve specific problems. This review focuses briefly on the epidemiology of neonatal thrombosis and the use of UFH in this population. It is followed by a discussion on dosing of UFH in neonates, limited evidence that forms the basis of published guidelines with justification for a treatment regimen that precludes the use of a heparin loading dose in newborns and monitoring of UFH therapy with currently available tests such as antifactor Xa (anti-Xa) level and activated partial thromboplastin time (APTT). Multiple studies have demonstrated a lack of correlation between anti-Xa levels and APTT as well as between different anti-Xa assays. Many centers world-wide rely only on APTT for monitoring purposes and do not have access to anti-Xa assays. To address these difficulties, we propose two practical algorithms, with and without the use of anti-Xa levels that clinicians can follow when monitoring UFH therapy in neonates. The article concludes with an overview of the side-effects of UFH. PMID:26656898

  12. Effective removal of humic acid using xanthan gum incorporated polyethersulfone membranes.

    Science.gov (United States)

    Sathish Kumar, R; Arthanareeswaran, G; Paul, Diby; Kweon, Ji Hyang

    2015-11-01

    In this study, xanthan gum (XA) was used as a hydrophilic biopolymer additive for the modification of polyethersulfone (PES) membrane to removal of humic acid (HA). The membranes are prepared using phase inversion technique and the concentration of XA was varied from 0.5 to 1.5wt%. The prepared membranes are characterized as a function of hydrophilicity, equilibrium water content (EWC), porosity studies and functional group analysis. Membrane surface and cross-sectional morphology was studied using scanning electron microscope. The lower contact angle value 64.2° was exhibited, when 1.5wt% of XA incorporated in PES membrane and this ensures that increase of hydrophilicity in pristine PES membrane. Further, higher water permeability (PWP) of 68.9(-9)m/skPa was observed for 1.5wt% of XA/PES membrane. The effect of pH on HA removal was studied for neat PES and XA/PES membranes. The rejection performance of XA incorporated in PES membranes were compared with commercial available PES membrane. PMID:25857244

  13. Chemical composition and bioreactivity of PM2.5 during 2013 haze events in China

    Science.gov (United States)

    Ho, Kin-Fai; Ho, Steven Sai Hang; Huang, Ru-Jin; Chuang, Hsiao-Chi; Cao, Jun-Ji; Han, Yongming; Lui, Ka-Hei; Ning, Zhi; Chuang, Kai-Jen; Cheng, Tsun-Jen; Lee, Shun-Cheng; Hu, Di; Wang, Bei; Zhang, Renjian

    2016-02-01

    Chemical composition and bioreactivity of PM2.5 samples collected from Beijing (BJ), Xi'an (XA), Xiamen (XM) and Hong Kong (HK) in China during haze events were characterized. PM2.5 mass concentrations in BJ, XA, XM and HK in the episodes were found to be 258 ± 100 μg m-3, 233 ± 52 μg m-3, 46 ± 9 μg m-3 and 48 ± 13 μg m-3, respectively. Significant increase of sulfate, nitrate and ammonium concentrations in northern cities were observed. High contributions of biomass burning emissions to organic carbon (OC) in northern cities were estimated in this study implying frequent biomass burning during the haze periods. The urea concentrations in PM2.5 were 1855 ± 755 ng m-3 (BJ), 1124 ± 243 ng m-3 (XA), 543 ± 104 ng m-3 (XM) and 363 ± 61 ng m-3 (HK) suggesting higher or close to upper limits compared to other regions in the world. Dose-dependent alterations in oxidative potential, IL-6, IFN-γ and TNF-α levels were also investigated. The oxidative potential levels are BJ > XM > XA > HK, whereas levels of IL-6, IFN-γ and TNF-α were BJ > XA > XM > HK. The sulfate, nitrate, ammonium, OC, urea and levoglucosan are associated with oxidative-inflammatory responses. These experimental results are crucial for the policymakers to implement cost-effective abatement strategies for improving air quality.

  14. An ultrasensitive electrochemical sensor for simultaneous determination of xanthine, hypoxanthine and uric acid based on Co doped CeO2 nanoparticles.

    Science.gov (United States)

    Lavanya, N; Sekar, C; Murugan, R; Ravi, G

    2016-08-01

    A novel electrochemical sensor has been fabricated using Co doped CeO2 nanoparticles for selective and simultaneous determination of xanthine (XA), hypoxanthine (HXA) and uric acid (UA) in a phosphate buffer solution (PBS, pH5.0) for the first time. The Co-CeO2 NPs have been prepared by microwave irradiation method and characterized by Powder XRD, Raman spectroscopy, HRTEM and VSM measurements. The electrochemical behaviours of XA, HXA and UA at the Co-CeO2 NPs modified glassy carbon electrode (GCE) were studied by cyclic voltammetry and square wave voltammetry methods. The modified electrode exhibited remarkably well-separated anodic peaks corresponding to the oxidation of XA, HXA and UA over the concentration range of 0.1-1000, 1-600 and 1-2200μM with detection limits of 0.096, 0.36, and 0.12μM (S/N=3), respectively. For simultaneous detection by synchronous change of the concentrations of XA, HXA and UA, the linear responses were in the range of 1-400μM each with the detection limits of 0.47, 0.26, and 0.43μM (S/N=3), respectively. The fabricated sensor was further applied to the detection of XA, HXA and UA in human urine samples with good selectivity and high reproducibility. PMID:27157753

  15. Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain

    Directory of Open Access Journals (Sweden)

    Elvis O Ameyaw

    2014-01-01

    Full Text Available Background: Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including headache and neuralgia. An animal model of vincristine-induced sensory neuropathy was developed after repeated intraperitoneal injection in rats and used in the present work to study the effects of the ethanolic extract of X. aethiopica (XAE and its diterpene xylopic acid (XA in vincristine-induced neuropathic pain. Materials and Methods: Vincristine (0.1 mg kg -1 day -1 was administered during two cycles of five consecutive days to induce chemotherapy-induced neuropathic pain. Static tactile anti-allodynic, anti-hyperalgesic, and cold anti-allodynic effects of XAE (30-300 mg kg -1 and XA (10-100 mg kg -1 were assessed using Von Frey filaments of bending forces of 4, 8, and 15 g, the Randall-Selitto paw pressure test, and cold water (4.5°C, respectively. Results: Administration of vincristine caused the development of allodynia and hyperalgesia with no significant motor deficit, spontaneous pain, and foot deformity. XAE (30-300 mg kg -1 and XA (10-100 mg kg -1 exhibited anti-hyperalgesic, tactile, and cold anti-allodynic properties with XA exhibiting greater potency than XAE. Pregabalin (10-100 mg kg -1 used as control produced similar effect. Conclusion: These findings establish the anti-allodynic and anti-hyperalgesic effects of the ethanolic fruit XAE and its major diterpene XA in vincristine-induced neuropathtic pain.

  16. Xanthurenic acid distribution, transport, accumulation and release in the rat brain.

    Science.gov (United States)

    Gobaille, Serge; Kemmel, Véronique; Brumaru, Daniel; Dugave, Christophe; Aunis, Dominique; Maitre, Michel

    2008-05-01

    Tryptophan metabolism through the kynurenine pathway leads to several neuroactive compounds, including kynurenic and picolinic acids. Xanthurenic acid (Xa) has been generally considered as a substance with no physiological role but possessing toxic and apoptotic properties. In the present work, we present several findings which support a physiological role for endogenous Xa in synaptic signalling in brain. This substance is present in micromolar amounts in most regions of the rat brain with a heterogeneous distribution. An active vesicular synaptic process inhibited by bafilomycin and nigericin accumulates xanthurenate into pre-synaptic terminals. A neuronal transport, partially dependant on adenosine 5'-triphosphate (ATP), sodium and chloride ions exists in NCB-20 neurons which could participate in the clearance of extracellular xanthurenate. Both transports (neuronal and vesicular) are greatly enhanced by the presence of micromolar amounts of zinc ions. Finally, electrical in vivo stimulation of A10-induced Xa release in the extracellular spaces of the rat prefrontal cortex. This phenomenon is reproduced by veratrine, K+ ions and blocked by EGTA and tetrodotoxin. These results strongly argue for a role for Xa in neurotransmission/neuromodulation in the rat brain, thus providing the existence of specific Xa receptors. PMID:18182052

  17. [Effect on low-molecular-weight heparin obtained using a chitinolytic complex on the anticoagulant activity of plasma in rabbits and rats].

    Science.gov (United States)

    Drozd, N N; Tolstenkov, A S; Makarov, V A; Miftakhova, N T; Bannikova, G E; Sukhanova, P P; Varlamov, V P; Vikhoreva, G E

    2007-01-01

    The anticoagulant activity of low-molecular-weight heparin with an average molecular weight of 4.7 kD (LMWH-4.7) has been studied. This derivative was prepared from unfractionated heparin with the help of chitinolytic enzyme complex from Streptomyces kurssanovii. The antithrombin activity of LMWH-4.7 (aIla activity) was 72 +/- 9 IU/mg and the activity with respect to the blood coagulation factor Xa (aXa activity) was 200 +/- 33 IU/mg, which corresponded to an aXa/aIIa ratio of 2.8 (necessary for effective antithrombotic drugs). The aIIa and aXa activity exhibited a dose-dependent variation upon intravenous and subcutaneous injections in rabbits, so that a high aIIa/aXa ratio was retained: 5 min after the intravenous injection of a minimum dose (0.3 mg/kg), this ratio was 2, 7, and for a greater dose (3.0 mg/kg) it reached 3.8. Subcutaneous injections were followed by slow elimination of the anticoagulant within 24 h. LMWH-4.7 upon intraperitoneal injections produced a dose-dependent inhibition of a model thrombosis in rats. Complete inhibition was observed for a dose of 3 mg/kg. Thus, it is possible to obtain active LMW heparin with the help of chitinases. PMID:17523450

  18. Study of amplified emission in polycrystalline ZnO below characteristic temperature

    CERN Document Server

    Tiwari, Sanjiv Kumar

    2012-01-01

    We report on amplified emission in polycrystalline ZnO below 100K. At 6K emission is due to free exciton FXn=1 A (3.378 eV), bound exciton D1XA (3.347 eV), donor acceptor pair DAP (3.275 eV) and longitudinal phonon replica of free excitons (FXn=1 A -mLO, m= 1,2,3) respectively. Peak intensity of D1XA and FXn=1 A -1LO transition increases non-linearly with increase of excitation intensity due to exciton-exciton scattering. Peak position of D1XA shows red shift while FXn=1 A -1LO shows blue shift with increase of excitation intensity. Fraction of exciton taking part in emission process and radiative lifetime of exciton decreases with decrease of temperature .Threshold value of excitation for D1XA decreases exponentially with decrease of temperature upto 100K. Whereas, below 100K no functional behaviour is observed. Threshold for FXn=1A-1LO emission was observed up to 75K, at higher temperature it is mixed with D1XA. Time delayed photoluminescence measurement reveals that amplified emission decay faster than spo...

  19. Xanthogranulomatous appendicitis in interval appendectomy specimens of children

    Directory of Open Access Journals (Sweden)

    Yusuf Hakan Çavuşoğlu

    2016-05-01

    Full Text Available Xanthogranulomatous inflammation is common in interval appendectomy specimens in adults, but it is unusual in children. Histopathologic specimens of interval appendectomy, within an 8-year period, were reevaluated to assess the true incidence. A computer search of the hospital database of all appendectomies was performed between January 2008 and June 2015 to identify all interval appendectomy cases. A total of 2694 patients underwent appendectomies. Of these, 13 were interval appendectomies. After pathologic evaluation, 2 (15.4% of the specimens were reported as xanthogranulomatous appendicitis (XA. Histopathologic examination of these interval appendectomy specimens, granulomas (59%, xanthogranulomatous inflammation (36% and Crohn-like changes (50% were common in adults. However, XA is a particularly rare clinical entity among children. Two cases of XA were reported in children in the English literature. One was a 12-year old boy that underwent interval appendectomy 6 weeks after an episode of acute appendicitis. The other was an 11-year old boy with acute (non-interval appendicitis, but the complete blood count was suggestive of an acute suppurative inflammation. These two cases are the 3rd and 4th cases of XA reported in children in the English literature, and both were managed by interval appendectomy. Thus, XA may be encountered in interval appendectomy specimens and association with IBD has to be ruled out.

  20. Kappa-symmetry of superstring sigma model and generalized 10d supergravity equations

    CERN Document Server

    Wulff, L

    2016-01-01

    We determine the constraints imposed on the 10d target superspace geometry by the requirement of classical kappa-symmetry of the Green-Schwarz superstring. In the type I case we find that the background must satisfy a generalization of type I supergravity equations. These equations depend on an arbitrary vector X_a and imply the one-loop scale invariance of the GS sigma model. In the special case when X_a is the gradient of a scalar \\phi (dilaton) one recovers the standard type I equations equivalent to the 2d Weyl invariance conditions of the superstring sigma model. In the type II case we find a generalized version of the 10d supergravity equations the bosonic part of which was introduced in arXiv:1511.05795. These equations depend on two vectors \\X_a and K_a subject to 1st order differential relations (with the equations in the NS-NS sector depending only on the combination X_a = \\X_a + K_a). In the special case of K_a=0 one finds that \\X_a=\\d_a \\phi and thus obtains the standard type II supergravity equat...