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Sample records for bien phong xa

  1. Exploiting VM/XA

    International Nuclear Information System (INIS)

    Boeheim, C.

    1990-03-01

    The Stanford Linear Accelerator Center has recently completed a conversion to IBM's VM/XA SP Release 2 operating system. The primary physics application had been constrained by the previous 16 megabyte memory limit. Work is underway to enable this application to exploit the new features of VM/XA. This paper presents a brief tutorial on how to convert an application to exploit VM/XA and discusses some of the SLAC experiences in doing so. 13 figs

  2. Des biens communs aux biens publics mondiaux

    Directory of Open Access Journals (Sweden)

    Bernard Hours

    2008-03-01

    Full Text Available La notion de « biens communs » est investie d’une portée particulière à une époque ou on utilise aussi le concept de "biens publics mondiaux" sorti tout droit des divers processus plurivoques qui constituent la globalisation aujourd’hui. Ces expressions, proches mais différentes, amènent nécessairement à s’interroger, moins sur la propriété que sur l’appropriation et ses différentes formes. Elles appellent aussi une réflexion sur la production de la valeur et la rareté. Cet article rappelle d’abord les principales approches anthropologiques sur la circulation des biens, les échanges, l’appropriation. La notion de biens communs renvoie à un âge d’or antérieur à la propriété, une sorte de paradis perdu largement mythique. On s’interroge ensuite sur la notion actuelle de biens publics mondiaux, qui vient  sublimer l’enfer de l’exploitation et de la concurrence à l’échelle globale.The notion of common good has a specific role at the present time of globalisation. The concept of global public good is also used in this context. These terms, close together but also different, bring to the questions of appropriation, production and scarcity. This article first reminds the main anthropological approaches on circulation of goods, exchanges, and appropriation. The notion of common goods makes a reference to a golden age, a lost paradise before property. Then we propose a critical analysis of global public goods which are supposed to sublimate  global exploitation and competition.

  3. Uptake of prenatal HIV testing in Hai Phong Province, Vietnam

    DEFF Research Database (Denmark)

    Nguyen, Lan; Christoffersen, Sarah Vigh; Rasch, Vibeke

    2010-01-01

    The objective of the study is to describe the uptake of prenatal HIV testing among Vietnamese women. Exit interviews were conducted among 300 women who had delivered at Hai Phong obstetrical hospital. Information about socioeconomic characteristics and HIV testing was obtained through structured ...... for HIV during prenatal care and that a relationship exists between distance to the hospital and lack of HIV testing during pregnancy.......The objective of the study is to describe the uptake of prenatal HIV testing among Vietnamese women. Exit interviews were conducted among 300 women who had delivered at Hai Phong obstetrical hospital. Information about socioeconomic characteristics and HIV testing was obtained through structured...... questionnaire interviews. It was found that 45% of the women were tested for HIV before the end of 34 weeks of gestation, 5% in 35 to 40 weeks of gestation, and 55% at labor. Low educational levels, being a farmer or worker, having a low income, and living close to the hospital were associated with being tested...

  4. Maximize x(a - x)

    Science.gov (United States)

    Lange, L. H.

    1974-01-01

    Five different methods for determining the maximizing condition for x(a - x) are presented. Included is the ancient Greek version and a method attributed to Fermat. None of the proofs use calculus. (LS)

  5. Ortholog Alleles at Xa3/Xa26 Locus Confer Conserved Race-Specific Resistance against Xanthomonas oryzae in Rice

    Institute of Scientific and Technical Information of China (English)

    Hong-Jing Li; Xiang-Hua Li; Jing-Hua Xiao; Rod A. Wing; Shi-Ping Wang

    2012-01-01

    The rice disease resistance (R) gene Xa3/Xa26 (having also been named Xa3 and Xa26) against Xanthomonas oryzae pv.oryzae (Xoo),which causes bacterial blight disease,belongs to a multiple gene family clustered in chromosome 11 and is from an AA genome rice cultivar (Oryza sativa L.).This family encodes leucine-rich repeat (LRR) receptor kinasetype proteins.Here,we show that the orthologs (alleles) of Xa3/Xa26,Xa3/Xa26-2,and Xa3/Xa26-3,from wild Oryza species O.officinalis (CC genome) and O.minuta (BBCC genome),respectively,were also R genes against Xoo.Xa3/Xa26-2 and Xa3/Xa26-3 conferred resistance to 16 of the 18 Xoo strains examined.Comparative sequence analysis of the Xa3/Xa26 families in the two wild Oryza species showed that Xa3/Xa26-3 appeared to have originated from the CC genome of O.minuta.The predicted proteins encoded by Xa3/Xa26,Xa3/Xa26-2,and Xa3/Xa26-3 share 91-99% sequence identity and 94-99% sequence similarity.Transgenic plants carrying a single copy of Xa3/Xa26,Xa3/Xa26-2,or Xa3/Xa26-3,in the same genetic background,showed a similar resistance spectrum to a set of Xoo strains,although plants carrying Xa3/Xa26-2 or Xa3/Xa26-3 showed lower resistance levels than the plants carrying Xa3/Xa26.These results suggest that the Xa3/Xa26 locus predates the speciation of A and C genome,which is approximately 7.5 million years ago.Thus,the resistance specificity of this locus has been conserved for a long time.

  6. Expressional and Biochemical Characterization of Rice Disease Resistance Gene Xa3/Xa26 Family

    Institute of Scientific and Technical Information of China (English)

    Songjie Xu; Yinglong Cao; Xianghua Li; Shiping Wang

    2007-01-01

    The rice (Oryza sativa L.) Xa3/Xa26 gene, conferring race-specific resistance to bacterial blight disease and encoding a leucine-rich repeat (LRR) receptor kinase-like protein, belongs to a multigene family consisting of tandem clustered homologous genes, colocalizing with several uncharacterized genes for resistance to bacterial blight or fungal blast. To provide more information on the expressional and biochemical characteristics of the Xa3/Xa26 family, we analyzed the family members. Four Xa3/Xa26 family members in the indica rice variety Teqing, which carries a bacterial blight resistance gene with a chromosomal location tightly linked to Xa3/Xa26, and five Xa3/Xa26 family members in the japonica rice variety Nipponbare, which carries at least one uncharacterized blast resistance gene, were constitutively expressed in leaf tissue. The result suggests that some of the family members may be candidates of these uncharacterized resistance genes. At least five putative N-glycosylation sites in the LRR domain of XA3/XA26 protein are not glycosylated. The XA3/XA26 and its family members MRKa and MRKc all possess the consensus sequences of paired cysteines, which putatively function in dimerization of the receptor proteins for signal transduction, immediately before the first LRR and immediately after the last LRR. However, no homo-dimer between the XA3/XA26 molecules or hetero-dimer between XA3/XA26 and MRKa or MRKc were formed, indicating that XA3/XA26 protein might function either as a monomer or a hetero-dimer formed with other protein outside of the XA3/XA26 family. These results provide valuable information for further extensive investigation into this multiple protein family.

  7. Colour computer-generated holography for point clouds utilizing the Phong illumination model.

    Science.gov (United States)

    Symeonidou, Athanasia; Blinder, David; Schelkens, Peter

    2018-04-16

    A technique integrating the bidirectional reflectance distribution function (BRDF) is proposed to generate realistic high-quality colour computer-generated holograms (CGHs). We build on prior work, namely a fast computer-generated holography method for point clouds that handles occlusions. We extend the method by integrating the Phong illumination model so that the properties of the objects' surfaces are taken into account to achieve natural light phenomena such as reflections and shadows. Our experiments show that rendering holograms with the proposed algorithm provides realistic looking objects without any noteworthy increase to the computational cost.

  8. Drug injecting and HIV risk among injecting drug users in Hai Phong, Vietnam: a qualitative analysis.

    Science.gov (United States)

    Ahmed, Tanvir; Long, Thanh Nguyen; Huong, Phan Thi; Stewart, Donald Edwin

    2015-01-29

    Hai Phong, located in northern Vietnam, has become a high HIV prevalence province among Injecting Drug Users (IDUs) since the infection shifted from the southern to the northern region of the country. Previous research indicates high levels of drug and sex related risk behaviour especially among younger IDUs. Our recent qualitative research provides a deeper understanding of HIV risk behaviour and highlights views and experiences of IDUs relating to drug injecting and sharing practices. Fifteen IDUs participated in semi-structured interviews conducted in September-October, 2012. Eligible participants were selected from those recruited in a larger scale behavioural research project and identified through screening questions. Interviews were conducted by two local interviewers in Vietnamese and were audiotaped. Ethical procedures, including informed consent and participants' understanding of their right to skip and withdraw, were applied. Transcripts were translated and double checked. The data were categorised and coded according to themes. Thematic analysis was conducted and a qualitative data analysis thematic framework was used. Qualitative analysis highlighted situational circumstances associated with HIV risks among IDUs in Hai Phong and revealed three primary themes: (i) places for injecting, (ii) injecting drugs in small groups, and (iii) sharing practices. Our results showed that shared use of jointly purchased drugs and group injecting were widespread among IDUs without adequate recognition of these as HIV risk behaviours. Frequent police raids generated a constant fear of arrest. As a consequence, the majority preferred either rail lines or isolated public places for injection, while some injected in their own or a friend's home. Price, a heroin crisis, and strong group norms encouraged collective preparation and group injecting. Risk practices were enhanced by a number of factors: the difficulty in getting new syringes, quick withdrawal management

  9. Clinical Scenarios for Discordant Anti-Xa

    Directory of Open Access Journals (Sweden)

    Jesus Vera-Aguilera

    2016-01-01

    Full Text Available Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Evidence Review. Guidelines and current literature search: we used PubMed, Medline, Embase, and MEDION, from 2000 to October 2013. Results. Anti-Xa test is widely used; however the assay underestimates heparin concentration in the presence of significant AT deficiency, pregnancy, end stage renal disease, and postthrombolysis and in patients with hyperbilirubinemia; limited published data evaluating the safety and effectiveness of anti-Xa assays for managing UH therapy is available. Conclusions and Relevance. To our knowledge this is the first paper that summarizes the most common causes in which this assay can be affected, several “day to day” clinical scenarios can modify the outcomes, and we concur that these rarely recognized scenarios can be affected by negative outcomes in the daily practice.

  10. Field evaluation of spatial repellency of metofluthrin impregnated plastic strips against mosquitoes in Hai Phong city, Vietnam.

    OpenAIRE

    Kawada, Hitoshi; Nguyen Thi Yen; Nguen Thuy Hoa; Truong Minh Sang; Nguyen Van Dan; Takagi, Masahiro

    2005-01-01

    Spatial repellency of metofluthrin-impregnated polyethylene plastic strips against mosquitoes, Aedes aegypti and Culex quinquefasciatus, were studied in a residential area in Hai Phong city, Vietnam. Thirty houses were selected as trial sites; half of these were assigned as untreated control and the other half were assigned for treatment.Primarily, irrespective of the room size, one room was treated with one strip. The dominant species in the trial sites were Culex quinquefasciatus and Aedes ...

  11. Silencing of the Rice Gene LRR1 Compromises Rice Xa21 Transcript Accumulation and XA21-Mediated Immunity.

    Science.gov (United States)

    Caddell, Daniel F; Park, Chang-Jin; Thomas, Nicholas C; Canlas, Patrick E; Ronald, Pamela C

    2017-12-01

    The rice immune receptor XA21 confers resistance to Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial leaf blight. We previously demonstrated that an auxilin-like protein, XA21 BINDING PROTEIN 21 (XB21), positively regulates resistance to Xoo. To further investigate the function of XB21, we performed a yeast two-hybrid screen. We identified 22 unique XB21 interacting proteins, including LEUCINE-RICH REPEAT PROTEIN 1 (LRR1), which we selected for further analysis. Silencing of LRR1 in the XA21 genetic background (XA21-LRR1Ri) compromises resistance to Xoo compared with control XA21 plants. XA21-LRR1Ri plants have reduced Xa21 transcript levels and reduced expression of genes that serve as markers of XA21-mediated activation. Overexpression of LRR1 is insufficient to alter resistance to Xoo in rice lines lacking XA21. Taken together, our results indicate that LRR1 is required for wild-type Xa21 transcript expression and XA21-mediated immunity.

  12. Field evaluation of spatial repellency of metofluthrin impregnated plastic strips against mosquitoes in Hai Phong City, Vietnam.

    Science.gov (United States)

    Kawada, Hitoshi; Yen, Nguyen Thi; Hoa, Nguyen Thuy; Sang, Truong Minh; VAN Dan, Nguyen; Takagi, Masahiro

    2005-08-01

    Spatial repellency of metofluthrin-impregnated polyethylene plastic strips against mosquitoes, Aedes aegypti and Culex quinquefasciatus, were studied in a residential area in Hai Phong city, Vietnam. Thirty houses were selected as trial sites; half of these were assigned as untreated control and the other half were assigned for treatment. Primarily, irrespective of the room size, one room was treated with one strip. The dominant species in the trial sites were Culex quinquefasciatus and Aedes aegypti. A rapid decrease in the mosquito index was observed immediately after the treatment with metofluthrin strips, and treatment was effective for at least 6 weeks.

  13. Finnish Government contribution in Haiphong Water Supply, Drainage, Sewerage and Sanitation Management Programs in Hai Phong city, Vietnam : A Case Study

    OpenAIRE

    Nguyen Hoang, Duy

    2015-01-01

    The objective of the thesis is to bring out a general point of view in the contribution of the Finnish aid of Finnish Government, targeted in the development of urban area as well as water supply and sanitation of Hai Phong city, the most Northern port city of Vietnam, which holds an important role in the economy system of Vietnam. Moreover, Hai Phong is one of three targeted cities that get Foreign Direct Investment as well as support from Finnish government for the development of local wate...

  14. Molecular screening of rice ( Oryza sativa L.) germplasm for Xa4 ...

    African Journals Online (AJOL)

    DNA fingerprinting results indicated the presence of Xa4 gene in 41 entries, while 14 lines were positive for xa5 gene. Only one local line was carrying Xa21 gene along with Xa4. Thus, the present study will not only be helpful for rice breeders to develop new rice varieties carrying disease resistant genes, but will also ...

  15. Activation of human factor V by factor Xa and thrombin

    International Nuclear Information System (INIS)

    Monkovic, D.D.; Tracy, P.B.

    1990-01-01

    The activation of human factor V by factor Xa and thrombin was studied by functional assessment of cofactor activity and sodium dodecyl sulfate-polycarylamide gel electrophoresis followed by either autoradiography of 125 I-labeled factor V activation products or Western blot analyses of unlabeled factor V activation products. Cofactor activity was measured by the ability of the factor V/Va peptides to support the activation of prothrombin. The factor Xa catalyzed cleavage of factor V was observed to be time, phospholipid, and calcium ion dependent, yielding a cofactor with activity equal to that of thrombin-activated factor V (factor Va). The cleavage pattern differed markedly from the one observed in the bovine system. The factor Xa activated factor V subunits expressing cofactor activity were isolated and found to consist of peptides of M r 220,000 and 105,000. Although thrombin cleaved the M r 220,000 peptide to yield peptides previously shown to be products of thrombin activation, cofactor activity did not increase. N-Terminal sequence analysis confirmed that both factor Xa and thrombin cleave factor V at the same bond to generate the M r 220,000 peptide. The factor Xa dependent functional assessment of 125 I-labeled factor V coupled with densitometric analyses of the cleavage products indicated that the cofactor activity of factor Xa activated factor V closely paralleled the appearance of the M r 220,000 peptide. The data indicate that factor Xa is as efficient an enzyme toward factor V as thrombin

  16. Marker-aided Incorporation of Xa38, a Novel Bacterial Blight Resistance Gene, in PB1121 and Comparison of its Resistance Spectrum with xa13 + Xa21.

    Science.gov (United States)

    Ellur, Ranjith K; Khanna, Apurva; S, Gopala Krishnan; Bhowmick, Prolay K; Vinod, K K; Nagarajan, M; Mondal, Kalyan K; Singh, Nagendra K; Singh, Kuldeep; Prabhu, Kumble Vinod; Singh, Ashok K

    2016-07-11

    Basmati rice is preferred internationally because of its appealing taste, mouth feel and aroma. Pusa Basmati 1121 (PB1121) is a widely grown variety known for its excellent grain and cooking quality in the international and domestic market. It contributes approximately USD 3 billion to India's forex earning annually by being the most traded variety. However, PB1121 is highly susceptible to bacterial blight (BB) disease. A novel BB resistance gene Xa38 was incorporated in PB1121 from donor parent PR114-Xa38 using a modified marker-assisted backcross breeding (MABB) scheme. Phenotypic selection prior to background selection was instrumental in identifying the novel recombinants with maximum recovery of recurrent parent phenome. The strategy was effective in delimiting the linkage drag to <0.5 mb upstream and <1.9 mb downstream of Xa38 with recurrent parent genome recovery upto 96.9% in the developed NILs. The NILs of PB1121 carrying Xa38 were compared with PB1121 NILs carrying xa13 + Xa21 (developed earlier in our lab) for their resistance to BB. Both NILs showed resistance against the Xoo races 1, 2, 3 and 6. Additionally, Xa38 also resisted Xoo race 5 to which xa13 + Xa21 was susceptible. The PB1121 NILs carrying Xa38 gene will provide effective control of BB in the Basmati growing region.

  17. Marker-aided Incorporation of Xa38, a Novel Bacterial Blight Resistance Gene, in PB1121 and Comparison of its Resistance Spectrum with xa13 + Xa21

    Science.gov (United States)

    Ellur, Ranjith K.; Khanna, Apurva; S, Gopala Krishnan.; Bhowmick, Prolay K.; Vinod, K. K.; Nagarajan, M.; Mondal, Kalyan K.; Singh, Nagendra K.; Singh, Kuldeep; Prabhu, Kumble Vinod; Singh, Ashok K.

    2016-01-01

    Basmati rice is preferred internationally because of its appealing taste, mouth feel and aroma. Pusa Basmati 1121 (PB1121) is a widely grown variety known for its excellent grain and cooking quality in the international and domestic market. It contributes approximately USD 3 billion to India’s forex earning annually by being the most traded variety. However, PB1121 is highly susceptible to bacterial blight (BB) disease. A novel BB resistance gene Xa38 was incorporated in PB1121 from donor parent PR114-Xa38 using a modified marker-assisted backcross breeding (MABB) scheme. Phenotypic selection prior to background selection was instrumental in identifying the novel recombinants with maximum recovery of recurrent parent phenome. The strategy was effective in delimiting the linkage drag to <0.5 mb upstream and <1.9 mb downstream of Xa38 with recurrent parent genome recovery upto 96.9% in the developed NILs. The NILs of PB1121 carrying Xa38 were compared with PB1121 NILs carrying xa13 + Xa21 (developed earlier in our lab) for their resistance to BB. Both NILs showed resistance against the Xoo races 1, 2, 3 and 6. Additionally, Xa38 also resisted Xoo race 5 to which xa13 + Xa21 was susceptible. The PB1121 NILs carrying Xa38 gene will provide effective control of BB in the Basmati growing region. PMID:27403778

  18. Risk Behaviors for HIV and HCV Infection Among People Who Inject Drugs in Hai Phong, Viet Nam, 2014.

    Science.gov (United States)

    Duong, Huong Thi; Jarlais, Don Des; Khuat, Oanh Hai Thi; Arasteh, Kamyar; Feelemyer, Jonathan; Khue, Pham Minh; Giang, Hoang Thi; Laureillard, Didier; Hai, Vinh Vu; Vallo, Roselyne; Michel, Laurent; Moles, Jean Pierre; Nagot, Nicolas

    2017-06-13

    We examined the potential for HIV and hepatitis C (HCV) transmission across persons who inject drugs (PWID), men-who-have-sex-with-men (MSM) and female commercial sex workers (CSW) PWID and the potential for sexual transmission of HIV from PWID to the general population in Hai Phong, Viet Nam. Using respondent driven and convenience sampling we recruited 603 participants in 2014. All participants used heroin; 24% used non-injected methamphetamine. HIV prevalence was 25%; HCV prevalence was 67%. HIV infection was associated with HCV prevalence and both infections were associated with length of injecting career. Reported injecting risk behaviors were low; unsafe sexual behavior was high among MSM-PWID and CSW-PWID. There is strong possibility of sexual transmission to primary partners facilitated by methamphetamine use. We would suggest future HIV prevention programs utilize multiple interventions including "treatment as prevention" to potential sexual transmission of HIV among MSM and CSW-PWID and from PWID to the general population.

  19. XA23 is an executor R protein and confers broad-spectrum disease resistance in rice.

    Science.gov (United States)

    Wang, Chunlian; Zhang, Xiaoping; Fan, Yinglun; Gao, Ying; Zhu, Qinlong; Zheng, Chongke; Qin, Tengfei; Li, Yanqiang; Che, Jinying; Zhang, Mingwei; Yang, Bing; Liu, Yaoguang; Zhao, Kaijun

    2014-11-09

    The majority of plant disease resistance (R) genes encode proteins that share common structural features. However, the transcription activator-like effector (TALE) associated executor type R genes show no considerable sequence homology to any known R genes. We adopted a map-based cloning approach and TALE-based technology to isolate and characterize Xa23, a new executor R gene derived from the wild rice (Oryza rufipogon) that confers an extremely broad spectrum of resistance to bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo). Xa23 encodes a 113-amino acid protein that shares 50% identity to the known executor R protein XA10. The predicted transmembrane helices in XA23 also overlap with those of XA10. Unlike Xa10, however, Xa23 transcription is specifically activated by AvrXa23, a TALE present in all examined Xoo field isolates. Moreover, the susceptible xa23 allele has an identical open reading frame of Xa23, but differs in promoter region by lacking the TALE binding-element (EBE) for AvrXa23. XA23 can trigger strong hypersensitive response in rice, tobacco and tomato. Our results provide the first evidence that plant genomes have an executor R gene family in which members execute their function and spectrum of disease resistance by recognizing the cognate TALEs in pathogen. © The Author 2014. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPB and IPPE, SIBS, CAS.

  20. Induction of Xa10-like Genes in Rice Cultivar Nipponbare Confers Disease Resistance to Rice Bacterial Blight.

    Science.gov (United States)

    Wang, Jun; Tian, Dongsheng; Gu, Keyu; Yang, Xiaobei; Wang, Lanlan; Zeng, Xuan; Yin, Zhongchao

    2017-06-01

    Bacterial blight of rice, caused by Xanthomonas oryzae pv. oryzae, is one of the most destructive bacterial diseases throughout the major rice-growing regions in the world. The rice disease resistance (R) gene Xa10 confers race-specific disease resistance to X. oryzae pv. oryzae strains that deliver the corresponding transcription activator-like (TAL) effector AvrXa10. Upon bacterial infection, AvrXa10 binds specifically to the effector binding element in the promoter of the R gene and activates its expression. Xa10 encodes an executor R protein that triggers hypersensitive response and activates disease resistance. 'Nipponbare' rice carries two Xa10-like genes in its genome, of which one is the susceptible allele of the Xa23 gene, a Xa10-like TAL effector-dependent executor R gene isolated recently from 'CBB23' rice. However, the function of the two Xa10-like genes in disease resistance to X. oryzae pv. oryzae strains has not been investigated. Here, we designated the two Xa10-like genes as Xa10-Ni and Xa23-Ni and characterized their function for disease resistance to rice bacterial blight. Both Xa10-Ni and Xa23-Ni provided disease resistance to X. oryzae pv. oryzae strains that deliver the matching artificially designed TAL effectors (dTALE). Transgenic rice plants containing Xa10-Ni and Xa23-Ni under the Xa10 promoter provided specific disease resistance to X. oryzae pv. oryzae strains that deliver AvrXa10. Xa10-Ni and Xa23-Ni knock-out mutants abolished dTALE-dependent disease resistance to X. oryzae pv. oryzae. Heterologous expression of Xa10-Ni and Xa23-Ni in Nicotiana benthamiana triggered cell death. The 19-amino-acid residues at the N-terminal regions of XA10 or XA10-Ni are dispensable for their function in inducing cell death in N. benthamiana and the C-terminal regions of XA10, XA10-Ni, and XA23-Ni are interchangeable among each other without affecting their function. Like XA10, both XA10-Ni and XA23-Ni locate to the endoplasmic reticulum (ER) membrane

  1. Identification of bacterial blight resistance genes Xa4 in Pakistani ...

    African Journals Online (AJOL)

    SERVER

    2008-03-04

    Mar 4, 2008 ... Bacterial blight (BB) caused by Xanthomonas oryzae pv oryzae (Xoo) is a major biotic constraint in the irrigated rice belts. Genetic resistance is the most effective and economical control for bacterial blight. Molecular survey was conducted to identify the rice germplasm/lines for the presence of Xa4, a.

  2. Factors Influencing Blood Cadmium and Mercury Concentrations in Residents of Agro-Industries along Nam Phong River, Thailand

    Directory of Open Access Journals (Sweden)

    Wannanapa Srathonghon

    2016-07-01

    Full Text Available This cross-sectional analytical study aimed to determine the blood levels of cadmium (B-Cd and mercury (B-Hg and identify the factors influencing heavy metal accumulation in residents of Agro-Industries along the Nam Phong River. Quantitative data were collected, and systematic random sampling was used to obtain 420 samples for questionnaire interview and serum heavy metal testing for B-Cd and B-Hg. Multiple regression analysis was used to identify factors influencing the accumulation of heavy metals in the population and report mean differences, 95% confidence intervals and p-values. The results indicated that B-Cd levels were within the recommended safety limits for human health (5 µg/dL. However, 4.29% of respondents had Hg levels higher than the recommended safety limits for human health (10 µg/dL. Factors influencing Cd levels included sex (mean difference=0.13 µg/L, 95% CI: 0.03-0.24, p-value=0.02 and smoking (mean difference=0.14 µg/L, 95% CI: 0.09-0.19, p-value<0.001. Factors influencing Hg levels included smoking (mean difference=1.06 µg/L, 95% CI: 0.52-1.61, p-value<0.001, fish consumption (mean difference=1.11 µg/L, 95% CI: 0.22-2.01, p-value=0.01 and river snail consumption (mean difference=0.56 µg/L, 95% CI: 0.03-0.19, p-value=0.03.

  3. Good governance and tourism development in protected areas: The case of Phong Nha-Ke Bang National Park, central Vietnam

    Directory of Open Access Journals (Sweden)

    Anna Hübner

    2014-06-01

    Full Text Available Protected areas are increasingly expected to serve as a natural income-producing resource via the exploitation of recreational and touristic activities. Whilst tourism is often considered a viable option for generating income which benefits the conservation of a protected area, there are many cases in which insufficient and opaque planning hinder sustainable development, thereby reducing local benefit sharing and, ultimately, nature conservation. This article delineated and examined factors in governance which may underlie tourism development in protected areas. Based on Graham, Amos and Plumptre’s five good governance principles, a specific analysis was made of the Phong Nha-Ke Bang National Park in central Vietnam, which highlighted challenges in the practical implementation of governing principles arising for nature conservation, sustainable tourism development and complex stakeholder environments. Despite the limited opportunity of this study to examine the wider national and international context, the discussion facilitated an overview of the factors necessary to understand governance principles and tourism development. This article could serve as a basis for future research, especially with respect to comparative analyses of different management structures existing in Vietnam and in other contested centrally steered protected area spaces. Conservation implications: This research has shown that tourism and its development, despite a more market-oriented and decentralised policymaking, is a fragmented concept impacted by bureaucratic burden, lack of institutional capacities, top-down processes and little benefit-sharing. There is urgent need for stakeholders – public and private – to reconcile the means of protected areas for the ends (conservation by clarifying responsibilities as well as structures and processes which determine decision-making.

  4. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

    International Nuclear Information System (INIS)

    Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

    2005-01-01

    Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis

  5. The rice XA21 ectodomain fused to the Arabidopsis EFR cytoplasmic domain confers resistance to Xanthomonas oryzae pv. oryzae.

    Science.gov (United States)

    Thomas, Nicholas C; Oksenberg, Nir; Liu, Furong; Caddell, Daniel; Nalyvayko, Alina; Nguyen, Yen; Schwessinger, Benjamin; Ronald, Pamela C

    2018-01-01

    Rice ( Oryza sativa ) plants expressing the XA21 cell-surface receptor kinase are resistant to Xanthomonas oryzae pv. oryzae (Xoo) infection. We previously demonstrated that expressing a chimeric protein containing the ELONGATION FACTOR Tu RECEPTOR (EFR) ectodomain and the XA21 endodomain (EFR:XA21) in rice does not confer robust resistance to Xoo . To test if the XA21 ectodomain is required for Xoo resistance, we produced transgenic rice lines expressing a chimeric protein consisting of the XA21 ectodomain and EFR endodomain (XA21:EFR) and inoculated these lines with Xoo . We also tested if the XA21:EFR rice plants respond to a synthetic sulfated 21 amino acid derivative (RaxX21-sY) of the activator of XA21-mediated immunity, RaxX. We found that five independently transformed XA21:EFR rice lines displayed resistance to Xoo as measured by lesion length analysis, and showed that five lines share characteristic markers of the XA21 defense response (generation of reactive oxygen species and defense response gene expression) after treatment with RaxX21-sY. Our results indicate that expression of the XA21:EFR chimeric receptor in rice confers resistance to Xoo . These results suggest that the endodomain of the EFR and XA21 immune receptors are interchangeable and the XA21 ectodomain is the key determinant conferring robust resistance to Xoo .

  6. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

    NARCIS (Netherlands)

    Connolly, Stuart J.; Milling, Truman J.; Eikelboom, John W.; Gibson, C. Michael; Curnutte, John T.; Gold, Alex; Bronson, Michele D.; Lu, Genmin; Conley, Pamela B.; Verhamme, Peter; Schmidt, Jeannot; Middeldorp, Saskia; Cohen, Alexander T.; Beyer-Westendorf, Jan; Albaladejo, Pierre; Lopez-Sendon, Jose; Goodman, Shelly; Leeds, Janet; Wiens, Brian L.; Siegal, Deborah M.; Zotova, Elena; Meeks, Brandi; Nakamya, Juliet; Lim, W. Ting; Crowther, Mark; Connolly, S. C.; Crowther, M.; Eikelboom, J.; Gibson, M.; Milling, T. J.; Albaladejo, P.; Cohen, A.; Lopez-Sendon, J.; Schmidt, J.; Verhamme, P.; Beyer-Westendorf, J.; Wyse, D. G.; Garcia, D.; Prins, M. [=Martin H.; Nakamya, J.; Büller, H. R.; Mahaffey, K.; Alexander, J.; Demchuk, A.; Raskob, G.; Schulman, S.; Meeks, B.; Zotova, E.; Holadyk-Gris, I.; Coppens, M.

    2016-01-01

    Background Andexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers. Methods In this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major

  7. Propriété, biens publics mondiaux, bien(s commun(s : Une lecture des concepts économiques

    Directory of Open Access Journals (Sweden)

    Jérôme Ballet

    2008-03-01

    Full Text Available La notion de bien public mondial s’est développée ces dernières années. Elle renvoie à un dépassement ambigu de la notion usuelle dans la théorie économique de bien public. A cette occasion elle ouvre le débat sur l’équité en complément de l’efficience. De ce fait, la confrontation de cette nouvelle notion avec l’analyse de l’efficience des régimes de propriété s’impose. Par ailleurs, la confrontation avec la notion de bien commun, notion elle aussi en développement, éclaire l’enjeu autour de l’équité.Property, Global Public Goods, Common Good(s : A Lecture. The concept of global public good emerged these last years. It proposes, in an ambiguous way, to go beyond the usual concept of public good. Then, added to usual questions on efficiency, the debate on fairness becomes a stake. Confrontation with analysis on property rights command attention, Furthermore, confrontation with the concept of common good, also a developing concept, highlight stake around fairness.

  8. Los bienes públicos y el derecho de propiedad

    Directory of Open Access Journals (Sweden)

    Jacqueline Morand-Deviller

    2013-10-01

    Full Text Available Las reflexiones realizadas sobre los bienes públicos experimentan en la actualidad un nuevo auge debido, principalmente, a la mundialización del concepto. Ciertamente, el aumento de las preocupaciones medioambientales resalta la importancia de una nueva categoría de bienes públicos, que todavía no ha sido abordada por los juristas: los bienes públicos mundiales, noción anglosajona que proviene de la economía y engloba a los bienes de valor universal, cuya gestión debe responder a objetivos de solidaridad. En este contexto, debe señalarse que uno de los principales elementos del debate acerca de los bienes públicos medioambientales es el análisis de las amenazas de sobreexplotación y degradación que les afecta. Por ello y para abordar este fenómeno, el presente trabajo distingue dos categorías de bienes (los bienes demaniales y los bienes públicos mundiales y nacionales y examina cómo se ejerce el derecho de propiedad sobre cada una de ellas, centrándose en los tres atributos del mismo: el abusus, el asits y e\\ fructus. Reflections collected in public property are currently experiencing a renewed prominence, due mainly to the globalization of the concept. Certainly, the increasing of environmental concerns highlights the importance of a new category of public goods, which hasn’t been addressed by the jurists yet: global public goods, Anglo-Saxon notion coming from the economy and that encompasses universal value goods, whose management must meet objectives of solidarity. In this context, it should be noted that one of the main elements of debate about environmental public goods is the analysis of the threats of overexploitation and degradation that affects them. Therefore, and to address this phenomenon, this paper identifies two categories of goods (financial assets and global and national public goods and examines how to exercise the property law on each of them, focusing on its three attributes: the abusus, usus and

  9. CONTROL DE INVENTARIO DE BIENES MUEBLES EN LA GERENCIA REGIONAL DE SALUD, AREQUIPA, 2010

    OpenAIRE

    REVILLA VELA, DELFINA LUISA

    2014-01-01

    VERIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA TASACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CODIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DEL ETIQUETADO EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA REGULARIZACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CONCILIACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES APRECIACIÓN GLOBAL SOBRE EL CONTROL DE INVENTARIO DE BIENES MUEBLE...

  10. Industrias de bienes de consumo buscan el éxito

    Directory of Open Access Journals (Sweden)

    José Ernesto Ramírez

    1987-04-01

    Full Text Available Requerimientos críticos para el éxito competitivo de las empresas, cuando se desarrolla su sistema de negocios: El caso de industrias seleccionadas de bienes de consumo en Colombia. Joseph Ganitsky Brandwayn. (Tesis de doctorado, Harvard University, School of Business Administration, 1974 University Microfilm International. Ann Arbor (Michigan. 1983, 317 páginas; 28 cuadros, 4 apéndices. (Disponible en la Biblioteca Luis Angel Arango.

  11. Theoretical calculation of shakeup intensities using Xa--SW wave functions

    International Nuclear Information System (INIS)

    Tse, J.S.; Loubriel, G.

    1981-01-01

    The ground and 1s core hole state molecular wave functions of CH 4 , NH 3 , H 2 O, and HF obtained from Xa--SW calculations using the touching spheres (TS) and overlapping spheres (OS) approximations are used to calculate the intensity of shakeup satellites observed in their ls core level photoelectron spectra. The sudden approximation was assumed in the calculation. In case of TS Xa--SW wave functions, the one electron overlap integral inside the intersphere was calculated via Green's theorem. For OS Xa--SW wave functions, the integration over the awkwardly shaped intersphere region was circumvented by distributing the intersphere charge into the atomic spheres according to the charge partition scheme suggested by Case and Karplus. Our results show that there are no significant differences between the shakeup energies calculated from the TS and OS approximations. However, shakeup intensities calculated from TS Xa--SW wave functions are more reliable and in better numerical agreement with experiment

  12. El deseo del bien o del bien aparente en ética a nicómaco iii.4

    OpenAIRE

    Gualdrón, Miguel

    2010-01-01

    La noción de “fin”, y el deseo de este fin, son cruciales dentro de la teoría aristotélica de la acción, en tanto sustentan no sólo la posibilidad misma de actuar, sino también la evaluación ética de la acción. El deseo de un fin en la acción es identificado en varios lugares de la obra de Aristóteles con el deseo del bien. En el capítulo 4 del libro III de la Ética a Nicómaco, Aristóteles plantea un problema en lo que concierne a este deseo, según el cual el deseo puede ser del bien en sí o ...

  13. Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation.

    Science.gov (United States)

    Xing, Junhao; Yang, Lingyun; Li, Hui; Li, Qing; Zhao, Leilei; Wang, Xinning; Zhang, Yuan; Zhou, Muxing; Zhou, Jinpei; Zhang, Huibin

    2015-05-05

    The coagulation enzyme factor Xa (fXa) plays a crucial role in the blood coagulation cascade. In this study, three-dimensional fragment based drug design (FBDD) combined with structure-based pharmacophore (SBP) model and structural consensus docking were employed to identify novel fXa inhibitors. After a multi-stage virtual screening (VS) workflow, two hit compounds 3780 and 319 having persistent high performance were identified. Then, these two hit compounds and several analogs were synthesized and screened for in-vitro inhibition of fXa. The experimental data showed that most of the designed compounds displayed significant in vitro potency against fXa. Among them, compound 9b displayed the greatest in vitro potency against fXa with the IC50 value of 23 nM and excellent selectivity versus thrombin (IC50 = 40 μM). Moreover, the prolongation of the prothrombin time (PT) was measured for compound 9b to evaluate its in vitro anticoagulant activity. As a result, compound 9b exhibited pronounced anticoagulant activity with the 2 × PT value of 8.7 μM. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  14. El comercio interprovincial de bienes en España

    OpenAIRE

    Esteban, Almudena; Llano, Carlos; Gallego, Nuria; Mata, Tamara de la

    2012-01-01

    En España no existe información oficial sobre el comercio interregional de bienes. En el marco del proyecto C-intereg se ha estimado la primera base de datos de comercio con detalle provincial, tomando como punto de partida la información disponible sobre transporte de mercancías junto con información adicional sobre precios específicos por regiones y productos. La metodología también incluye varios ejercicios de depuración y armonización con las cifras oficiales de producción ...

  15. Ética empresarial, responsabilidad social y bienes comunicativos

    OpenAIRE

    Calvo, Patrici

    2014-01-01

    Desde su irrupción en el panorama económico, la responsabilidad social se ha conceptualizado de muy distintas formas. Algunas relacionadas con la filantropía, el mecenazgo, la estrategia o el marketing empresarial. Este estudio pretende mostrar que la empresa necesita gestionar debidamente aquellos bienes comunicativos que, como la confianza, la reputación o la reciprocidad, están implicados en el correcto desarrollo de su actividad y, por consiguiente, en la maximización del beneficio económ...

  16. How useful is determination of anti-factor Xa activity to guide bridging therapy with enoxaparin? A pilot study.

    Science.gov (United States)

    Hammerstingl, Christoph; Omran, Heyder; Tripp, Christian; Poetzsch, Bernd

    2009-02-01

    Low-molecular-weight heparins (LMWH) are commonly used as peri-procedural bridging anticoagulants. The usefulness of measurement of anti-factor Xa activity (anti-Xa) to guide bridging therapy with LMWH is unknown. It was the objective of this study to determine levels of anti-Xa during standard bridging therapy with enoxaparin, and to examine predictors for residual anti-Xa. Consecutive patients receiving enoxaparin at a dosage of 1 mg/kg body weight/12 hours for temporary interruption of phenprocoumon were prospectively enrolled to the study. Blood-samples were obtained 14 hours after LMWH-application immediately pre- procedurally. Procedural details, clinical and demographic data were collected and subsequently analyzed. Seventy patients were included (age 75.2 +/- 10.8 years, Cr Cl 55.7 +/- 21.7ml/min, body mass index [BMI] 27.1 +/- 4.9). LMWH- therapy was for a mean of 4.2 +/- 1.6 days; overall anti-Xa was 0.58 +/- 0.32 U/ml. In 37 (52.8%) of patients anti-Xa was > or U/ml, including 10 (14.3%) patients with anti-Xa > 1U/ml. Linear regression analysis of single variables and logistic multivariable regression analysis failed to prove a correlation between anti-Xa and single or combined factors. No major bleeding, no thromboembolism and four (5.7%) minor haemorrhages were observed. When bridging OAC with therapeutic doses of enoxaparin a high percentage of patients undergo interventions with high residual anti-Xa. The levels of anti-Xa vary largely and are independent of single or combined clinical variables. Since the anti-Xa-related outcome of patients receiving bridging therapy with LMWH is not investigated, no firm recommendation on the usefulness of monitoring of anti-Xa can be given at this stage.

  17. El mercado de bienes ilegales: el caso de la droga

    Directory of Open Access Journals (Sweden)

    Becker , Gary S.

    2006-12-01

    Full Text Available Este artículo examina los costos de reducir el consumo de un bien declarando ilegal su producción y castigando a los productores ilegales. Las drogas son el ejemplo más destacado. Cuanto más inelástica es la demanda o la oferta, mayor es el incremento del costo social de reducir la producción con mayor represión. Así, el gasto público óptimo de capturar y condenar a los proveedores ilegales no sólo depende de la diferencia entre los valores social y privado del consumo sino también de las elasticidades. Cuando la demanda y la oferta no son muy elásticas, no paga hacer cumplir la prohibición a menos que el valor social sea negativo. También muestra que un impuesto monetario reduce la producción e incrementa el precio más que la represión óptima del bien si fuera ilegal, aunque algunos productores vayan a la clandestinidad para evadir el impuesto monetario. Los impuestos al consumo y las restricciones a las cantidades no son equivalentes cuando la represión tiene costos

  18. 3D/3D registration of coronary CTA and biplane XA reconstructions for improved image guidance

    Energy Technology Data Exchange (ETDEWEB)

    Dibildox, Gerardo, E-mail: g.dibildox@erasmusmc.nl; Baka, Nora; Walsum, Theo van [Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Punt, Mark; Aben, Jean-Paul [Pie Medical Imaging, 6227 AJ Maastricht (Netherlands); Schultz, Carl [Department of Cardiology, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Niessen, Wiro [Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, 2628 CJ Delft, The Netherlands and Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands)

    2014-09-15

    Purpose: The authors aim to improve image guidance during percutaneous coronary interventions of chronic total occlusions (CTO) by providing information obtained from computed tomography angiography (CTA) to the cardiac interventionist. To this end, the authors investigate a method to register a 3D CTA model to biplane reconstructions. Methods: The authors developed a method for registering preoperative coronary CTA with intraoperative biplane x-ray angiography (XA) images via 3D models of the coronary arteries. The models are extracted from the CTA and biplane XA images, and are temporally aligned based on CTA reconstruction phase and XA ECG signals. Rigid spatial alignment is achieved with a robust probabilistic point set registration approach using Gaussian mixture models (GMMs). This approach is extended by including orientation in the Gaussian mixtures and by weighting bifurcation points. The method is evaluated on retrospectively acquired coronary CTA datasets of 23 CTO patients for which biplane XA images are available. Results: The Gaussian mixture model approach achieved a median registration accuracy of 1.7 mm. The extended GMM approach including orientation was not significantly different (P > 0.1) but did improve robustness with regards to the initialization of the 3D models. Conclusions: The authors demonstrated that the GMM approach can effectively be applied to register CTA to biplane XA images for the purpose of improving image guidance in percutaneous coronary interventions.

  19. XA readout chip characteristics and CdZnTe spectral measurements

    International Nuclear Information System (INIS)

    Barbier, L.M.; Birsa, F.; Odom, J.

    1999-01-01

    The authors report on the performance of a CdZnTe (CZT) array readout by an XA (X-ray imaging chip produced at the AMS foundry) application specific readout chip (ASIC). The array was designed and fabricated at NASA/Goddard Space Flight Center (GSFC) as a prototype for the Burst Arc-Second Imaging and Spectroscopy gamma-ray instrument. The XA ASIC was obtained from Integrated Detector and Electronics (IDE), in Norway. Performance characteristics and spectral data for 241 Am are presented both at room temperature and at -20 C. The measured noise (σ) was 2.5 keV at 60 keV at room temperature. This paper represents a progress report on work with the XA ASIC and CZT detectors. Work is continuing and in particular, larger arrays are planned for future NASA missions

  20. Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data?

    Directory of Open Access Journals (Sweden)

    Ali Zalpour

    2011-01-01

    Full Text Available The association between cancer and venous thromboembolism (VTE has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment has been anticoagulation therapy, unless contraindicated. This therapy consists of unfractionated heparin (UFH, low-molecular-weight heparin (LMWH, factor Xa inhibitor, or vitamin K antagonist (VKA. Current guidelines recommend LMWH over VKA for the treatment of VTE in cancer patients. Factor-specific anticoagulants have been proven safe and effective, and recently factor Xa inhibitors have emerged as a treatment alternative to heparins and VKA. Currently, three factor Xa inhibitors have been identified: fondaparinux (the only one approved so far by the US Food and Drug Administration, idraparinux (in clinical trials, and idrabiotaparinux (in clinical trials. This paper will examine the role of these agents, focusing on fondaparinux, for the prevention and treatment of VTE in cancer patients.

  1. Introduction of a rice blight resistance gene, Xa21, into five Chinese rice varieties through an Agrobacterium-mediated system

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A cloned gene, Xa21 was transferred into five widely-used Chinese rice varieties through an Agrobacterium-mediated system, and over 110 independent transgenic lines were obtained. PCR and Southern analysis of transgenic plants revealed the integration of the whole Xa21 gene into the host genomes. The integrated Xa21 gene was stably inherited, and segregated in a 3∶1 ratio in the selfed T1 generation when one copy of the gene was integrated in the transformants. Inoculation tests displayed that transgenic T0 plants and Xa21 PCR-positive T1 plants were highly resistant to bacterial blight disease. The selected Xa21 homozygous resistant transgenic lines with desirable qualities may be propagated as new varieties or utilized in hybrid rice breeding.

  2. Introduction of a rice blight resistance gene, Xa21, into five Chinese rice varieties through an Agrobacterium -mediated system

    Institute of Scientific and Technical Information of China (English)

    翟文学; 李晓兵; 田文忠; 周永力; 潘学彪; 曹守云; 赵显峰; 赵彬; 章琦; 朱立煌

    2000-01-01

    A cloned gene, Xa21 was transferred into five widely-used Chinese rice varieties through an Agrobacterium-mediated system, and over 110 independent transgenic lines were obtained. PCR and Southern analysis of transgenic plants revealed the integration of the whole Xa21 gene into the host genomes. The integrated Xa21 gene was stably inherited, and segregated in a 3 : 1 ratio in the selfed T1 generation when one copy of the gene was integrated in the transfor-mants. Inoculation tests displayed that transgenic T0 plants and Xa21 PCR-positive T1 plants were highly resistant to bacterial blight disease. The selected Xa21 homozygous resistant transgenic lines with desirable qualities may be propagated as new varieties or utilized in hybrid rice breeding.

  3. Los bienes comunes intangibles en el capitalismo cognitivo.

    Directory of Open Access Journals (Sweden)

    Álvaro Ramis Olivos

    2014-10-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Este texto analizará críticamente la actual fase económica para mostrar la importancia de los bienes comunes intangibles. Sondea la tesis de un nuevo modo de producción «en ciernes», basado en la gestión colaborativa. Analiza los intangibles de acuerdo a su calidad y carácter. Compara los sistemas de patentes y derechos de propiedad intelectual que permiten su apropiación y las resistencias a su «comoditización» desde el software libre y las propuestas de flexibilización de derechos de autor. Advierte sobre el «fetichismo tecnológico» y propone un marco mínimo de discernimiento en dilemas vinculados a estas materias. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

  4. 78 FR 24677 - Safety Zone; XA The Experimental Agency Fireworks, Pier 34, East River, NY

    Science.gov (United States)

    2013-04-26

    ... Final Rule This rule establishes a temporary safety zone on the navigable waters of the East River, in... Fireworks, Pier 34, East River, NY. (a) Regulated Area. The following area is a temporary safety zone: all... 1625-AA00 Safety Zone; XA The Experimental Agency Fireworks, Pier 34, East River, NY AGENCY: Coast...

  5. Developing an Anti-Xa-Based Anticoagulation Protocol for Patients with Percutaneous Ventricular Assist Devices.

    Science.gov (United States)

    Sieg, Adam; Mardis, B Andrew; Mardis, Caitlin R; Huber, Michelle R; New, James P; Meadows, Holly B; Cook, Jennifer L; Toole, J Matthew; Uber, Walter E

    2015-01-01

    Because of the complexities associated with anticoagulation in temporary percutaneous ventricular assist device (pVAD) recipients, a lack of standardization exists in their management. This retrospective analysis evaluates current anticoagulation practices at a single center with the aim of identifying an optimal anticoagulation strategy and protocol. Patients were divided into two cohorts based on pVAD implanted (CentriMag (Thoratec; Pleasanton, CA) / TandemHeart (CardiacAssist; Pittsburgh, PA) or Impella (Abiomed, Danvers, MA)), with each group individually analyzed for bleeding and thrombotic complications. Patients in the CentriMag/TandemHeart cohort were subdivided based on the anticoagulation monitoring strategy (activated partial thromboplastin time (aPTT) or antifactor Xa unfractionated heparin (anti-Xa) values). In the CentriMag/TandemHeart cohort, there were five patients with anticoagulation titrated based on anti-Xa values; one patient developed a device thrombosis and a major bleed, whereas another patient experienced major bleeding. Eight patients received an Impella pVAD. Seven total major bleeds in three patients and no thrombotic events were detected. Based on distinct differences between the devices, anti-Xa values, and outcomes, two protocols were created to guide anticoagulation adjustments. However, anticoagulation in patients who require pVAD support is complex with constantly evolving anticoagulation goals. The ideal level of anticoagulation should be individually determined using several coagulation laboratory parameters in concert with hemodynamic changes in the patient's clinical status, the device, and the device cannulation.

  6. Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.

    Directory of Open Access Journals (Sweden)

    Kathleen E Brummel-Ziedins

    Full Text Available Factor (fXa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate hemostasis in various populations. In this study, we evaluate the potential of computationally derived time courses of fXa generation as another approach for investigating thrombotic risk. Utilizing the case (n = 473 and control (n = 426 population from the Leiden Thrombophilia Study and each individual's plasma protein factor composition for fII, fV, fVII, fVIII, fIX, fX, antithrombin and tissue factor pathway inhibitor, tissue factor-initiated total active fXa generation was assessed using a mathematical model. FXa generation was evaluated by the area under the curve (AUC, the maximum rate (MaxR and level (MaxL and the time to reach these, TMaxR and TMaxL, respectively. FXa generation was analyzed in the entire populations and in defined subgroups (by sex, age, body mass index, oral contraceptive use. The maximum rates and levels of fXa generation occur over a 10- to 12- fold range in both cases and controls. This variation is larger than that observed with thrombin (3-6 fold in the same population. The greatest risk association was obtained using either MaxR or MaxL of fXa generation; with an ∼2.2 fold increased risk for individuals exceeding the 90(th percentile. This risk was similar to that of thrombin generation(MaxR OR 2.6. Grouping defined by oral contraceptive (OC use in the control population showed the biggest differences in fXa generation; a >60% increase in the MaxR upon OC use. FXa generation can distinguish between a subset of individuals characterized by overlapping thrombin generation profiles. Analysis of fXa generation is a phenotypic characteristic which may prove to be a more sensitive discriminator than thrombin generation among all individuals.

  7. Ciberciudadanía, cultura y bienes públicos

    Directory of Open Access Journals (Sweden)

    Álvarez, J. Francisco

    2009-06-01

    Full Text Available Net society is provoking dramatic changes in several aspects of our daily life as cultural traits, business and the more disparages spheres of privacy and social life. We must attend both to freedom of access and to new services generation because of the peculiar form public goods are raising in the Net. To supersede individual capability limitations and to diffuse digital and cultural gaps, electronic government could be a cultural decisive tool in this phase of cibersociety enhancement. Technologies enhanced the human capabilities, as well as with the social actions and its framework, including cultural production and management. Technologies are also transforming the generation, reproduction and transmission of (social knowledge.La sociedad red transforma la vida cotidiana, las diversas manifestaciones culturales, los negocios, las esferas más diversas de la vida privada y social. La forma en que se generan los bienes públicos en la red exige una preocupación explícita por la libertad de acceso y la generación de nuevos servicios, que ayuden a superar limitaciones de los individuos y faciliten desdibujar las diversas brechas digitales y ciberculturales. El gobierno electrónico resulta culturalmente decisivo en esta fase de expansión de la cibersociedad. Las tecnologías amplían las capacidades humanas, expanden el espacio y las formas de acción social, incluidas la producción y gestión cultural. También producen cambios en las formas de generación, reproducción y transmisión del conocimiento (social.

  8. Pluralismo y bien común en el derecho constitucional

    Directory of Open Access Journals (Sweden)

    Pablo Nuevo

    2004-01-01

    Full Text Available En el presente artículo, el profesor Pablo Nuevo analiza las consecuencias que el abandono de la doctrina del bien común tiene en el derecho constitucional, a partir del estudio de la incoporación de valores al ordenamiento jurídico que realiza la Constitución Española de 1978. Esta incorporación parecería dotar de contenido material a la Constitución, que pasa a estar al servicio de la dignidad de la persona y de los valores de justicia, libertad, igualdad y pluralismo político. No obstante esta positivación de un orden axiológico, a juicio de Nuevo, el entendiminiento que el Tribunal Constitucional ha realizado del valor pluralismo contribuye a debilitar el propio Estado constitucional pues el Tribunal, de la mano del principio democrático y de la soberanía popular, ha interpretado el valor pluralismo como relativismo, negando a los valores un fundamento más allá del consenso. Entender el pluralismo como igual legitimidad de toda representación del hombre y del mundo, que funda un derecho a seguir dicha concepción en todos los aspectos de la vida social, favorece que los postulados de la Constitución sean entendidos como significantes sin significado, debiendo éste ser construido a partir del principio mayoritario, lo que conduce tanto al debilitamiento de los derechos fundamentales, como a la progresiva erosión de las condiciones sociales en que puede favorecer el Estado constitucional. Como subraya el autor, el Estado moderno vive de presupuestos que no puede crear, pero sí en todo caso destruir. De igual manera, para el profesor el constitucionalismo liberal, pluralista e individualista de nuestros tiempos, carece de herramientas conceptuales para solucionar las aporías que plantea las sociedades occidentales de nuestro tiempo, que se debaten entre el miedo al Leviatán y la inseguridad de un mundo anómico. El autor sostiene que solo con una vuelta a la ley natural es posible ordenar la vida política de manera que

  9. First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa

    OpenAIRE

    Verghese, Jenson; Liang, Aiye; Sidhu, Preet Pal Singh; Hindle, Michael; Zhou, Qibing; Desai, Umesh R.

    2009-01-01

    Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that i) selected monomeric benzofuran derivatives inhibit the two enzymes, albeit weakly; ii) the two enzymes recognize different structural features in the benzofurans studied suggesting significant selectivity of recognition; and iii) the mechanism of...

  10. Fine mapping of the rice bacterial blight resistance gene Xa-4 and its co-segregation marker

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    An F2 population developed from the Xa-4 near isogenic lines,IR24 and IRBB4,was used for fine mapping of the rice bacterial blight resistance gene,Xa-4.Some restriction fragment length polymorphism (RFLP) markers on the high-density map constructed by Harushima et al.and the amplified DNA fragments homologous to the conserved domains of plant disease resistance (R) genes were used to construct the genetic linkage map around the gene Xa-4 by scoring susceptible individuals in the population.Xa-4 was mapped between the RFLP marker G181 and the polymerase chain reaction (PCR) marker M55.The R gene homologous fragment marker RS13 was found co-segregating with Xa-4 by analyzing all the plants in the population.This result opened an approach to map-based cloning of this gene,and marker RS13 can be applied to molecular marker-assisted selection of Xa-4 in rice breeding programs.

  11. Assessment of anti-factor Xa activity of heparin in binary parenteral nutrition admixtures for premature neonates.

    Science.gov (United States)

    Foinard, A; Perez, M; Barthélémy, C; Lannoy, D; Flamein, F; Storme, L; Tournoys, A; Décaudin, B; Odou, P

    2015-07-01

    An in vitro study was carried out to determine the anti-Xa activity of heparin in binary parenteral nutrition (BPN) admixtures for premature neonates in our neonatal intensive care unit (NICU) after a 24-hour infusion, as well as to assess drug interaction with a 50% glucose solution. Two types of bags were prepared: (1) BPN admixtures (composition defined in the NICU) including sodium heparin at 77 UI/mL and (2) bags containing only G50% with sodium heparin at 193 UI/mL. The anti-Xa activity of heparin was measured in bags at T0, after the 24-hour infusion and in eluates at the outlet of the infusion line after 24hours, using a validated chromogenic anti-Xa method. Comparisons of the mean concentration observed with the theoretical value for anti-Xa activity were performed with the Student t-test. Mean values of anti-Xa activity do not differ significantly from the values expected for all conditions. We found a slight variation in anti-Xa activity when infused over 24hours for both types of bags, with and without in-line filtration, showing that heparin remains stable during this infusion period in both BPN admixtures and G50%. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  12. First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa.

    Science.gov (United States)

    Verghese, Jenson; Liang, Aiye; Sidhu, Preet Pal Singh; Hindle, Michael; Zhou, Qibing; Desai, Umesh R

    2009-08-01

    Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that (i) selected monomeric benzofuran derivatives inhibit the two enzymes, albeit weakly; (ii) the two enzymes recognize different structural features in the benzofurans studied suggesting significant selectivity of recognition; and (iii) the mechanism of inhibition is allosteric. The molecules represent the first allosteric small molecule inhibitors of the two enzymes.

  13. First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa

    Science.gov (United States)

    Verghese, Jenson; Liang, Aiye; Sidhu, Preet Pal Singh; Hindle, Michael; Zhou, Qibing; Desai, Umesh R.

    2009-01-01

    Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that i) selected monomeric benzofuran derivatives inhibit the two enzymes, albeit weakly; ii) the two enzymes recognize different structural features in the benzofurans studied suggesting significant selectivity of recognition; and iii) the mechanism of inhibition is allosteric. The molecules represent the first allosteric small molecule inhibitors of the two enzymes. PMID:19540113

  14. TRASMISIÓN DE BIENES Y REGISTRO DE LA PROPIEDAD EN ESPAÑA (SEGUNDA PARTE

    Directory of Open Access Journals (Sweden)

    Joaquín Sánchez Cebrián

    2009-01-01

    Full Text Available La circulación de los bienes en el tráfico jurídico por la voluntad de los particulares es un tema crucial que interesa, no sólo a las partes del contrato, sino, a todos en general, y, en particular, a los acreedores del transmitente o del adquirente y a los terceros adquirentes de derechos sobre el bien. En este trabajo se analizará el régimen de trasmisión de los bienes por negocio inter vivos en el Derecho español, dentro del marco europeo, y con particular referencia a la trasmisión inmobiliaria. España adopta un peculiar sistema de trasmisión de los bienes porque se establecen reglas genéricas cuya aplicación se da con independencia de la naturaleza mueble o inmueble del bien; pero a su lado se superponen otras que tratan de fijar los efectos de la publicidad registral inmobiliaria. La coordinación entre dichas reglas produce un original resultado, que puede constituir el punto de encuentro de los diversos sistemas registrales europeos.

  15. Oral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of deep vein thrombosis.

    Science.gov (United States)

    Robertson, Lindsay; Kesteven, Patrick; McCaslin, James E

    2015-06-30

    Deep vein thrombosis (DVT) is a condition in which a clot forms in the deep veins, most commonly of the leg. It occurs in approximately 1 in 1,000 people. If left untreated, the clot can travel up to the lungs and cause a potentially life-threatening pulmonary embolism (PE). Previously, a DVT was treated with the anticoagulants heparin and vitamin K antagonists. However, two forms of novel oral anticoagulants (NOACs) have been developed: oral direct thrombin inhibitors (DTI) and oral factor Xa inhibitors. The new drugs have characteristics that may be favourable over conventional treatment, including oral administration, a predictable effect, lack of frequent monitoring or re-dosing and few known drug interactions. To date, no Cochrane review has measured the effectiveness and safety of these drugs in the treatment of DVT. To assess the effectiveness of oral DTIs and oral factor Xa inhibitors for the treatment of DVT. The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched January 2015) and the Cochrane Register of Studies (last searched January 2015). We searched clinical trials databases for details of ongoing or unpublished studies and the reference lists of relevant articles retrieved by electronic searches for additional citations. We included randomised controlled trials in which people with a DVT confirmed by standard imaging techniques, were allocated to receive an oral DTI or an oral factor Xa inhibitor for the treatment of DVT. Two review authors (LR, JM) independently extracted the data and assessed the risk of bias in the trials. Any disagreements were resolved by discussion with the third review author (PK). We performed meta-analyses when we considered heterogeneity low. The two primary outcomes were recurrent VTE and PE. Other outcomes included all-cause mortality and major bleeding. We calculated all outcomes using an odds ratio (OR) with a 95% confidence interval (CI). We included

  16. Le bien commun : pour l’égalité et la liberté

    OpenAIRE

    David, Françoise

    2015-01-01

    Dans ce texte, l’auteure dresse un portrait de la position de D’abord solidaires, collectif de lutte contre la montée d’idées de droite, en ce qui concerne la question du bien commun. Françoise David dénonce l’idée du bien commun que peuvent se faire nos élites politiques en démontrant les dangers qui guettent les sociétés qui négligent de prendre en considération les conséquences à long terme des actions de celles-là. Pour D’abord solidaires, le bien commun en appelle plutôt à l’idée d’une c...

  17. FacturaBien : Sistema de gestión de facturación y contabilidad

    OpenAIRE

    García Núñez, Marcos

    2015-01-01

    El presente documento describe en detalle el proyecto de desarrollo de una aplicación web de gestión, llamada 'FacturaBien'. Esta aplicación permite realizar todas las tareas asociadas a la gestión administrativa de la actividad empresarial de una manera eficiente y cómoda, automatizando un gran número de tareas. Aquest document descriu en detall el projecte de desenvolupament d'una aplicació web de gestió, anomenada 'FacturaBien'. Aquesta aplicació permet realitzar totes les tasques assoc...

  18. Valoración económica de bienes ambientales.

    OpenAIRE

    Orrego Suaza, Sergio Alonso; Cerda Urrutia, Arcadio; Vásquez Lavín, Felipe

    2011-01-01

    El trabajo describe los distintos métodos de valoración económica de bienes ambientales y su utilización en estudios de impacto sobre el entorno para obtener estimaciones monetarias de los efectos negativos sobre la calidad ambiental de recursos naturales específicos.

  19. El CIESPAL cambió para bien mi visión profesional

    Directory of Open Access Journals (Sweden)

    Juan Carlos Peña Gutiérrez

    2010-09-01

    Full Text Available El autor es un becario del CIESPAL (1989 quien da cuenta pormenorizada de la extraordinaria experiencia que obtuvo en el Curso Taller sobre "Producción de Programas Informativos para la radio", cambiando para bien la visión profesional que le dio grandes satisfacciones en su natal Bolivia.

  20. Le point sur les indices du bien-être national | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    21 janv. 2011 ... Les indices économiques sont des outils statistiques qui résument des ... En quelques mots, le PIB correspond à la valeur totale des biens et ... copieux menu d'instruments de mesure allant du réjouissant Happy Planet Index, ...

  1. Comparative Transcriptome Profiling of Rice Near-Isogenic Line Carrying Xa23 under Infection of Xanthomonas oryzae pv. oryzae.

    Science.gov (United States)

    Tariq, Rezwan; Wang, Chunlian; Qin, Tengfei; Xu, Feifei; Tang, Yongchao; Gao, Ying; Ji, Zhiyuan; Zhao, Kaijun

    2018-03-02

    Bacterial blight, caused by Xanthomonas oryzae pv. oryzae ( Xoo ), is an overwhelming disease in rice-growing regions worldwide. Our previous studies revealed that the executor R gene Xa23 confers broad-spectrum disease resistance to all naturally occurring biotypes of Xoo . In this study, comparative transcriptomic profiling of two near-isogenic lines (NILs), CBB23 (harboring Xa23 ) and JG30 (without Xa23 ), before and after infection of the Xoo strain, PXO99 A , was done by RNA sequencing, to identify genes associated with the resistance. After high throughput sequencing, 1645 differentially expressed genes (DEGs) were identified between CBB23 and JG30 at different time points. Gene Ontlogy (GO) analysis categorized the DEGs into biological process, molecular function, and cellular component. KEGG analysis categorized the DEGs into different pathways, and phenylpropanoid biosynthesis was the most prominent pathway, followed by biosynthesis of plant hormones, flavonoid biosynthesis, and glycolysis/gluconeogenesis. Further analysis led to the identification of differentially expressed transcription factors (TFs) and different kinase responsive genes in CBB23, than that in JG30. Besides TFs and kinase responsive genes, DEGs related to ethylene, jasmonic acid, and secondary metabolites were also identified in both genotypes after PXO99 A infection. The data of DEGs are a precious resource for further clarifying the network of Xa23 -mediated resistance.

  2. El sumo bien kantiano: el objeto construído de la ley moral

    Directory of Open Access Journals (Sweden)

    Alonso Villarán

    2016-01-01

    Full Text Available El presente artículo tiene tres objetivos: a. compilar las críticas planteadas en contra del sumo bien kantiano (un mundo donde la virtud es premiada con felicidad; b. elaborar una revisión crítica de las respectivas defensas; y c. desarrollar una nueva defensa, con énfasis en el problema de derivación (según el cual el sumo bien no se deriva de la ley moral. Respecto al primero punto, el artículo muestra que son al menos cinco los problemas que amenazan la doctrina: heteronomía, derivación, imposibilidad, irrelevancia y dualismo. Respecto al segundo, el artículo revela que las múltiples defensas elaboradas en nombre del sumo bien son fuente, a su vez, de otros problemas, como los de incompletitud, ilusión, injusticia, deslealtad y escisión. Respecto al tercer y principal punto, y empezando por la derivación, el artículo propone ver al sumo bien como el objeto construido de la ley moral. Resuelto el problema de derivación, el artículo ofrece breves respuestas a los otros problemas en juego. El artículo también traduce por primera vez, del inglés al español, fragmentos de importantes publicaciones sobre el sumo bien.

  3. XaNSoNS: GPU-accelerated simulator of diffraction patterns of nanoparticles

    Directory of Open Access Journals (Sweden)

    V.S. Neverov

    2017-01-01

    Full Text Available XaNSoNS is an open source software with GPU support, which simulates X-ray and neutron 1D (or 2D diffraction patterns and pair-distribution functions (PDF for amorphous or crystalline nanoparticles (up to ∼107 atoms of heterogeneous structural content. Among the multiple parameters of the structure the user may specify atomic displacements, site occupancies, molecular displacements and molecular rotations. The software uses general equations nonspecific to crystalline structures to calculate the scattering intensity. It supports four major standards of parallel computing: MPI, OpenMP, Nvidia CUDA and OpenCL, enabling it to run on various architectures, from CPU-based HPCs to consumer-level GPUs.

  4. XaNSoNS: GPU-accelerated simulator of diffraction patterns of nanoparticles

    Science.gov (United States)

    Neverov, V. S.

    XaNSoNS is an open source software with GPU support, which simulates X-ray and neutron 1D (or 2D) diffraction patterns and pair-distribution functions (PDF) for amorphous or crystalline nanoparticles (up to ∼107 atoms) of heterogeneous structural content. Among the multiple parameters of the structure the user may specify atomic displacements, site occupancies, molecular displacements and molecular rotations. The software uses general equations nonspecific to crystalline structures to calculate the scattering intensity. It supports four major standards of parallel computing: MPI, OpenMP, Nvidia CUDA and OpenCL, enabling it to run on various architectures, from CPU-based HPCs to consumer-level GPUs.

  5. Atributos característicos de las marcas de bienes de lujo Atributos característicos de las marcas de bienes de lujo

    Directory of Open Access Journals (Sweden)

    Carlos Mario Uribe Saldarriaga

    2006-06-01

    Full Text Available Este artículo presenta una síntesis de la investigación desarrollada por el autor como trabajode grado en el Magíster en Ciencias de la Administración de la Universidad EAFIT. La investigación se centra en la identificación y comprensión de los atributos que caracterizan a las marcas de bienes reconocidas como de lujo, mediante la aplicación de la metodología de investigación denominada análisis de contenido, a una muestra de conveniencia de sitios web de dichas marcas. La investigación se circunscribe al ámbito de estudio del mercadeo y utiliza sus diferentes conceptos para determinar tanto el marco de referencia como la caracterizaciónde los atributos de las marcas de bienes de lujo.This article is a synthesis of the research study conducted by the author as a requirement for the MSc in Management at EAFIT University. The objective in this research is to identify and understand the attributes that characterize brands, acknowledged as luxury goods. The content analysis was chosen as the research method for studying a convenience sample of luxury brand sites on the Internet.  This research study is developed in the marketing field, and its different concepts were adopted as the reference framework.

  6. Oral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of pulmonary embolism.

    Science.gov (United States)

    Robertson, Lindsay; Kesteven, Patrick; McCaslin, James E

    2015-12-04

    Pulmonary embolism is a potentially life-threatening condition in which a clot can travel from the deep veins, most commonly in the leg, up to the lungs. Previously, a pulmonary embolism was treated with the anticoagulants heparin and vitamin K antagonists. Recently, however, two forms of direct oral anticoagulants (DOACs) have been developed: oral direct thrombin inhibitors (DTI) and oral factor Xa inhibitors. The new drugs have characteristics that may be favourable over conventional treatment, including oral administration, a predictable effect, lack of frequent monitoring or re-dosing and few known drug interactions. To date, no Cochrane review has measured the effectiveness and safety of these drugs in the long-term treatment (minimum duration of three months) of pulmonary embolism. To assess the effectiveness of oral DTIs and oral factor Xa inhibitors for the long-term treatment of pulmonary embolism. The Cochrane Vascular Trials Search Co-ordinator searched the Specialised Register (last searched January 2015) and the Cochrane Register of Studies (last searched January 2015). Clinical trials databases were also searched for details of ongoing or unpublished studies. We searched the reference lists of relevant articles retrieved by electronic searches for additional citations. We included randomised controlled trials in which patients with a pulmonary embolism confirmed by standard imaging techniques were allocated to receive an oral DTI or an oral factor Xa inhibitor for the long-term (minimum duration three months) treatment of pulmonary embolism. Two review authors (LR, JM) independently extracted the data and assessed the risk of bias in the trials. Any disagreements were resolved by discussion with the third author (PK). We used meta-analyses when we considered heterogeneity low. The two primary outcomes were recurrent venous thromboembolism and pulmonary embolism. Other outcomes included all-cause mortality and major bleeding. We calculated all outcomes

  7. Bien-être animal en élevage de poulets de chair

    OpenAIRE

    Arnould, Cécile; Leterrier, Christine

    2007-01-01

    L’élevage des poulets de chair s’est intensifié ces dernières décennies et de nombreux problèmes de bien-être animal sont apparus, en particulier chez les poulets standards et les reproducteurs à l’origine de ces croisements. Les poulets standards ont un niveau d’activité très faible et ils sont notamment atteints de troubles locomoteurs, de lésions cutanées et de pathologies cardio-vasculaires. Des solutions à ces altérations du bien-être peuvent être apportées en contrôlant des facteurs lié...

  8. Santé et biens communs : un regard de juriste.

    Directory of Open Access Journals (Sweden)

    Isabelle Moine-Dupuis

    2010-11-01

    Full Text Available La santé constitue un domaine dans lequel les notions de bien commun ou de bien public mondial sont particulièrement pertinentes. Il faut cependant préciser de quels biens il est question. A titre d’exemple, le droit français comporte des notions susceptibles de qualifier le droit aux soins (comme droit inaliénable, ou le médicament, objet de propriété intellectuelle comme de propriété « traditionnelle ». Un droit international des biens de santé peut de la même manière être fondé sur un droit d’usage de chacun sur la molécule qui est la même dans le médicament générique et celui de marque. Une procédure d’accès équivalent aux produits, brevetés ou non, pourrait être mise en œuvre par principe dès la découverte, afin de parvenir rapidement à des prix équitables.Health is a field particularly suitable for notions as commons or public goods. It is necessary however to know which goods may be concerned. For instance, French lawyers use concepts which can be used in order to qualify right to care (as an inalienable right, or medicine as an object of intellectual property as well as “traditional” one. An international law for health goods could be also based on a right of use for each person on the molecule which is the same in the generic drug or in the patented one. A process of “equivalent access” to licensed or free products could be initiated, from the discovery itself to the use, in order to obtain rapidly fair prices.

  9. Libéralisation du commerce des biens et services TIC : enjeux et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Libéralisation du commerce des biens et services TIC : enjeux et implications pour la mise en oeuvre de politiques publiques en Afrique de l'Ouest. En Afrique de l'Ouest, les entreprises du secteur privé des technologies d'information et de la communication (TIC) ont démontré leur capacité à créer des emplois et à stimuler ...

  10. Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system.

    Science.gov (United States)

    Ishihara, Tsukasa; Koga, Yuji; Iwatsuki, Yoshiyuki; Hirayama, Fukushi

    2015-01-15

    Anticoagulant agents have emerged as a promising class of therapeutic drugs for the treatment and prevention of arterial and venous thrombosis. We investigated a series of novel orally active factor Xa inhibitors designed using our previously reported conjugation strategy to boost oral anticoagulant effect. Structural optimization of anthranilamide derivative 3 as a lead compound with installation of phenolic hydroxyl group and extensive exploration of the P1 binding element led to the identification of 5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide (33, AS1468240) as a potent factor Xa inhibitor with significant oral anticoagulant activity. We also reported a newly developed Free-Wilson-like fragment recommender system based on the integration of R-group decomposition with collaborative filtering for the structural optimization process. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Assessment of anti-factor Xa activity of enoxaparin for venous thromboembolism prophylaxis in morbidly obese surgical patients

    Directory of Open Access Journals (Sweden)

    Nouf Al Otaib

    2017-01-01

    Conclusions: Weight-based enoxaparin dose led to the anticipated peak anti-Xa levels (0.2–0.6 IU/mL in most of the morbidly obese study patients undergoing surgery without any evidence of major side effects. The weight-based dosing of enoxaparin was also effective in preventing VTE in all patients. Although these results are promising, further comparative trials are needed in the setting of morbidly obese surgical patients.

  12. Externalidades regionales y la provisión de bienes públicos en un sistema descentralizado de gobiernos subnacionales

    Directory of Open Access Journals (Sweden)

    Raúl Alberto Ponce Rodríguez

    2010-01-01

    Full Text Available En este artículo se desarrolla un modelo electoral de votos probabilísticos para racionalizar la provisión de bienes públicos locales en un sistema descentralizado de gobiernos locales autónomos. En nuestra economía, la heterogeneidad de preferencias por bienes públicos conlleva a un problema de elección social que es resuelto mediante una elección estatal. El modelo teórico sugiere una serie de proposiciones sobre los determinantes del gasto público que pueden ser verificadas empíricamente. En particular, el modelo sugiere que si los bienes públicos no muestran externalidades regionales, el gasto del gobierno es explicado por la distribución del ingreso y la población en la entidad. Si los bienes públicos muestran externalidades regionales, la distribución del ingreso y el costo de los bienes públicos a lo largo de la economía (y no sólo de la entidad determinan el gasto público estatal. El modelo también permite identificaralgunas configuraciones del ingreso en la economía que pueden llevar a asimetrías en la oferta de bienes públicos que resultan de una reducción en el promedio del costo per cápita de los bienes públicos.

  13. Marker-Assisted Selection of Xa21 Conferring Resistance to Bacterial Leaf Blight in indica Rice Cultivar LT2

    Directory of Open Access Journals (Sweden)

    Hue Thi Nguyen

    2018-01-01

    Full Text Available Bacterial leaf blight of rice (BLB, caused by Xanthomonas oryzae pv. oryzae, is one of the most destructive diseases in Asian rice fields. A high-quality rice variety, LT2, was used as the recipient parent. IRBB21, which carries the Xa21 gene, was used as the donor parent. The resistance gene Xa21 was introduced into LT2 by marker-assisted backcrossing. Three Xoo races were used to inoculate the improved lines following the clipping method. Eleven BC3F3 lines carrying Xa21 were obtained based on molecular markers and agronomic performance. The 11 lines were then inoculated with the three Xoo races. All the 11 improved lines showed better resistance to BLB than the recipient parent LT2. Based on the level of resistance to BLB and their agronomic performance, five lines (BC3F3 5.1.5.1, BC3F3 5.1.5.12, BC3F3 8.5.6.44, BC3F3 9.5.4.1 and BC3F3 9.5.4.23 were selected as the most promising for commercial release. These improved lines could contribute to rice production in terms of food security.

  14. Marker-Assisted Selection of Xa21 Conferring Resistance to Bacterial Leaf Blight in indica Rice Cultivar LT2

    Institute of Scientific and Technical Information of China (English)

    Hue Thi NGUYEN; Trung Nguyen DINH; Nakano TOSHITSUGU; Liet Van VU; Quang Hong VU; Tan Van MAI; Thu Thi NGUYEN; Lam Duc VU; Tung Thanh NGUYEN; Long Viet NGUYEN; Hien Thu Thi VU; Hue Thi NONG

    2018-01-01

    Bacterial leaf blight of rice (BLB), caused by Xanthomonas oryzae pv. oryzae, is one of the most destructive diseases in Asian rice fields. A high-quality rice variety, LT2, was used as the recipient parent. IRBB21, which carries the Xa21 gene, was used as the donor parent. The resistance gene Xa21 was introduced into LT2 by marker-assisted backcrossing. Three Xoo races were used to inoculate the improved lines following the clipping method. Eleven BC3F3lines carrying Xa21 were obtained based on molecular markers and agronomic performance. The 11 lines were then inoculated with the three Xoo races. All the 11 improved lines showed better resistance to BLB than the recipient parent LT2. Based on the level of resistance to BLB and their agronomic performance, five lines (BC3F35.1.5.1, BC3F35.1.5.12, BC3F38.5.6.44, BC3F3 9.5.4.1 and BC3F39.5.4.23) were selected as the most promising for commercial release. These improved lines could contribute to rice production in terms of food security.

  15. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity.

    Science.gov (United States)

    Lee, Wonhwa; Kim, Mi-Ae; Park, InWha; Hwang, Jae Sam; Na, MinKyun; Bae, Jong-Sup

    2017-11-01

    Tenebrio molitor is an edible insect that has antimicrobial, anticancer, and antihypertensive effects. The aim of this study was to identify the unreported bioactive compounds from T. molitor larvae with inhibitory activities against factor Xa (FXa) and platelet aggregation. Isolated compounds were evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity, and thrombus formation. A diketopiperazine (1, cyclo( L -Pro- L -Tyr)) and a phenylethanoid (2, N-acetyltyramine) were isolated and inhibited the catalytic activity of FXa in a mixed inhibition model and inhibited platelet aggregation induced by adenosine diphosphate (ADP) and U46619. They inhibited ADP- and U46619-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) and the expression of P-selectin and PAC-1 in platelets. They also improved the production of nitric oxide and inhibited the oversecretion of endothelin-1 compared to that of the ADP- or U46619-treated group. In an animal model of arterial and pulmonary thrombosis, the isolated compounds showed enhanced antithrombotic effects. They also elicited anticoagulant effects in mice. Compounds 1-2 inhibited ADP-, collagen-, or U46619-induced platelet aggregation and showed similar anti-thrombotic efficacy to rivaroxaban, a positive control. Therefore, 1-2 could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Bioassay-directed fractionation of a blood coagulation factor Xa inhibitor, betulinic acid from Lycopus lucidus

    Directory of Open Access Journals (Sweden)

    Tan Yin-Feng

    2018-03-01

    Full Text Available Thrombosis is a major cause of morbidity and mortality worldwide and plays a pivotal role in the pathogenesis of several cardiovascular disorders, including acute coronary syndrome, unstable angina, myocardial infarction, sudden cardiac death, peripheral arterial occlusion, ischemic stroke, deep-vein thrombosis, and pulmonary embolism. Anticoagulants, antiplatelet agents, and fibrinolytics can reduce the risks of these clinical events. Especially, the blood coagulation factor Xa (FXa inhibitor is a proven anticoagulant. Promoting blood circulation, using traditional Chinese medicine (TCM, for the treatment of these diseases has been safely used for thousands of years in clinical practice. Therefore, highly safe and effective anticoagulant ingredients, including FXa inhibitors, could be found in TCM for activating the blood circulation. One FXa inhibitor, a pentacyclic triterpene (compound 1, betulinic acid characterized by IR, MS and NMR analyses, was isolated from the ethyl acetate fraction of Lycopus lucidus by bioassay-directed fractionation. Compound 1 exhibited an inhibitory effect on FXa with IC50 25.05 μmol/L and reduced the thrombus weight in an animal model at 25-100 mg/kg. These results indicate that betulinic acid could be the potential for anticoagulant therapy.

  17. The Factor of Structure and Mechanical Properties in the Production of Critical Fixing Hardware 38XA

    Directory of Open Access Journals (Sweden)

    G.V. Pachurin

    2016-09-01

    Full Text Available Fixing hardware made of carbon, high-carbon, and alloyed wires is one of the widespread critical parts in mechanical engineering. The characteristics of fixtures and fasteners and their performance figures are assessed at all stages of steel-making operation, from the choice of burden stock for metal smelting to the method of preparing calibrated rolled metal parts and upsetting end products. Material used for producing long high-duty bolts must be both sufficiently strong and ductile, have homogeneous mechanical properties and chemistry, and no inner or surface defects. When manufacturing fasteners, hot-rolled metal is often plastically deformed by drafting before cold upsetting, and all unacceptable defects are removed by the expensive procedure of lathe-turning. Moreover, this technology of metal processing entails losses of up to 5.5 % in chips. This paper suggests a resource-efficient and environmentally friendlier fabrication method for calibrated rolled metal items made of steel 38XA, 9.65 mm diameter, for cold die-forging of high-duty bolts used in automotive engines, which helps spare expensive lathe-machining processes. Moreover, rolled steel produced using this technology is characterized by high resistance to plastic deformation when cold, which leads to increase n wear-resistance of tools in cold die-forging of bolts.

  18. Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity

    International Nuclear Information System (INIS)

    Du, Lanying; Kao, Richard Y.; Zhou, Yusen; He, Yuxian; Zhao, Guangyu; Wong, Charlotte; Jiang, Shibo; Yuen, Kwok-Yung; Jin, Dong-Yan; Zheng, Bo-Jian

    2007-01-01

    The spike (S) protein of SARS coronavirus (SARS-CoV) has been known to recognize and bind to host receptors, whose conformational changes then facilitate fusion between the viral envelope and host cell membrane, leading to viral entry into target cells. However, other functions of SARS-CoV S protein such as proteolytic cleavage and its implications to viral infection are incompletely understood. In this study, we demonstrated that the infection of SARS-CoV and a pseudovirus bearing the S protein of SARS-CoV was inhibited by a protease inhibitor Ben-HCl. Also, the protease Factor Xa, a target of Ben-HCl abundantly expressed in infected cells, was able to cleave the recombinant and pseudoviral S protein into S1 and S2 subunits, and the cleavage was inhibited by Ben-HCl. Furthermore, this cleavage correlated with the infectivity of the pseudovirus. Taken together, our study suggests a plausible mechanism by which SARS-CoV cleaves its S protein to facilitate viral infection

  19. Contemporary developments in the discovery of selective factor Xa inhibitors: A review.

    Science.gov (United States)

    Patel, Nirav R; Patel, Dushyant V; Murumkar, Prashant R; Yadav, Mange Ram

    2016-10-04

    Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized world. Venous thromboembolism is observed in about 1 million people every year in United States causing significant morbidity and mortality. Conventional antithrombotic therapy has been reported to have several disadvantages and limitations like inconvenience in oral administration, bleeding risks (heparin analogs), narrow therapeutic window and undesirable interactions with food and drugs (vitamin K antagonist-warfarin). The unmet medical demand for orally active safe anticoagulants has generated widespread interest among the medicinal chemists engaged in this field. To modulate blood coagulation, various enzymes involved in the coagulation process have received great attention as potential targets by various research groups for the development of oral anticoagulants. Among these enzymes, factor Xa (FXa) has remained the centre of attention in the last decade. Intensive research efforts have been made by various research groups for the development of small, safe and orally bioavailable FXa inhibitors. This review is an attempt to compile the research work of various researchers in the direction of development of FXa inhibitors reported since 2010 onward. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. OF THE COMMON GOOD TO THE COMMON GOOD OF HUMANITY. DE LOS BIENES COMUNES AL BIEN COMÚN DE LA HUMANIDAD.

    Directory of Open Access Journals (Sweden)

    François Houtart.

    2014-06-01

    éndum sobre el agua (uno de los bienes comunes en Italia, la Fundación Rosa Luxemburgo tomó la decisión de organizar una Conferencia sobre el concepto del Bien Común de la Humanidad, para promover una reflexión sobre los vínculos entre las dos nociones y de integrar las reivindicaciones y las luchas sociales para un cambio de sociedad, escenario en el que se enmarca éste artículo.

  1. Los Bienes Destinados al Uso General: Tratamiento Contable en Diferentes Administraciones Locales Europeas

    Directory of Open Access Journals (Sweden)

    María Teresa Balaguer Coll

    2001-06-01

    Full Text Available Como respuesta a la necesidad de una mayor información para la gestión, los sistemas contables públicos han sido sometidos a un proceso general de reforma, especialmente en la administración local. Estas reformas afectan, entre otros, al tratamiento contable de los activos fijos. Dada la especial naturaleza que poseen algunos de estos activos, como es el caso de los bienes destinados a uso general, este artículo tiene por objeto analizar la problemática contable que tales bienes originan, mostrando diferentes posturas académicas y las prácticas contables de las entidades locales en diferentes países europeos. En general, se aprecia una clara tendencia a la presentación de mayor información sobre el activo fijo en los estados financieros, siendo el criterio de valoración más utilizado el coste histórico. Palabras clave: bienes de uso general, contabilidad pública, entidades locales europeas. ABSTRACT In response to the need for better management information, pubic sector accounting systems have been subjected to a general reform process, especially in local government. These reforms cover, among other things, accounting for capital assets. Given the special nature of some of these assets, such as community assets, this article aims to analyse the problematic roots of accounting, examining different academic positions as well as the accounting rules and practices of local authorities in different European countries. In general, there appears to be a clear tendency to present more information on capital assets in financial statements, with historic cost being the most utilised valuation criteria.

  2. Bitcoin: Documentos electrónicos para el intercambio de bienes y servicios

    OpenAIRE

    García Alejo, Luis Antonio

    2016-01-01

    [ES] Al hablar de Bitcoin no se hace alusión simplemente a una única cosa, al bien digital como tal, sino que nos referimos también al protocolo de envío y recepción de mensajes, basado en Open Source, a la red P2P (Par- a- par) y las propias criptomonedas (Bitcoins). Su creador, bajo el seudónimo de Satoshi Nakamoto, pretendía crear un proyecto con un objetivo principal: que las transacciones económicas entre dos personas no necesiten de un organismo central o ningún tipo de intermediario. E...

  3. Régimen de separación de bienes en el Código civil

    OpenAIRE

    Sánchez de Prada, Ángela

    2015-01-01

    Todo matrimonio requiere hacer frente a una serie de obligacones que genera la existencia de cualquier familia. En todo régimen económico matrimonial rige la obligación que tienen los cónyuges de contribuir al levantamiento de las cargas del matrimonio; no obstante, este tratamiento ha de ser matizado en el régimen de separación de bienes. El trabajo para la casa será computado como contribución a las cargas y dará derecho a una compensación que el juez, a falta de acuerdo, determinará. Este ...

  4. Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

    Directory of Open Access Journals (Sweden)

    Liveri Angeliki

    2010-01-01

    Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

  5. Bienes globales y protección colectiva: el caso del derecho de consumo

    OpenAIRE

    Gómez Pomar, Fernando

    2012-01-01

    En el ámbito de bienes globales, como es la protección del consumidor, las acciones de protección plantean una problemática especial y de particular dificultad. En derecho de consumo, dada la naturaleza dispersa de los efectos negativos de muchos comportamientos de infracción, los mecanismos tradicionales para lograr el cumplimiento de las normas de Derecho Privado se enfrentan a obstáculos con frecuencia insuperables. Las acciones colectivas pueden obtener economías de escala ...

  6. El reconocimiento de los bienes de dominio público: El caso de los municipios portugueses

    Directory of Open Access Journals (Sweden)

    Susana Catarino Rua

    2016-02-01

    Full Text Available Objeto: Este trabajo tiene por objetivos analizar el mencionado en el POCAL (1999, en las NICSP del IPSASB y en diversas opiniones doctrinales con respecto al reconocimiento de los bienes de dominio público (BDP, así como verificar si existen problemas inherentes al reconocimiento de los BDP en Portugal, superables con la adopción de las NICSP. Diseño/metodología/Enfoque: Para este estudio, fue efectuada una revisión de literatura, de la posición del POCAL (1999, de las NICSP del IPSASB, y de la perspectiva doctrinal, con respecto al reconocimiento de los bienes de dominio público. Además, se realizó un estudio de la evolución de los valores de los bienes de dominio público, de los años 2006 a 2013, del total de los 308 municipios portugueses, para concluir acerca de la existencia de dificultades en el reconocimiento de estos activos y de la necesidad de adoptar los normativos internacionales. Aportaciones y Resultados: En algunos municipios portugueses, el proceso de inventario aún no está concluido, existiendo dificultades con respecto al reconocimiento de los BDP. Dichas dificultades resultan de que el POCAL (1999 no presenta los requisitos para el reconocimiento de los activos; problema superado en la NICSP nº 17 del IPSASB (2006b, que refiere esos requisitos. Adoptar un nuevo Sistema de Normalización Contable aplicable a la Administración Pública (SNC-AP, basado en las NICSP, puede ser la solución para dichas cuestiones, introduciendo criterios a considerar en el reconocimiento de los activos, que aseguren la comparabilidad de la información y de los valores del patrimonio de los municipios portugueses. Limitaciones: La inexistencia de criterios de reconocimiento a seguir por los municipios trae limitaciones al nivel de la comparabilidad de los valores de los diferentes componentes del activo presentados por los varios municipios. Valor añadido: Este trabajo nos enseña que, en Portugal, aún existen problemas con

  7. Responsabilidad social de los consumidores en la compra de bienes de consumo

    OpenAIRE

    Peña López, Alicia

    2017-01-01

    La responsabilidad social del consumidor en la compra de bienes de consumo abarca una muy amplia variedad de sectores, por lo que este trabajo se ha centrado exclusivamente en el análisis de la sensibilidad del distribuidor y consumidor a la compra de alimentos éticamente responsables en España, haciendo especial hincapié en los productos con certificado Fairtrade. Un primer estudio sobre estos productos ha mostrado cómo las ventas en España se han incrementado durante los últimos años, sin e...

  8. El libre desarrollo de la personalidad (Un bien jurídico digno del Estado constitucional)

    OpenAIRE

    Migu Ontiveros Alonso

    2006-01-01

    Con fundamento en la dignidad humana, en su calidad de valor fundamental plasmado en toda Constitución moderna, el autor propone incorporar, en calidad de bien jurídicamente protegido, al libre desarrollo de la personalidad, con el objeto de proteger a los grupos especialmente vulnerables ante los delitos vinculados a la explotación humana. el libre desarrollo de la personalidad, se afirma en este breve artículo, puede ser equiparado a la vida humana como valor supero del se...

  9. La obsolescencia programada en el bien de consumo y la dinámica del mercado

    OpenAIRE

    Espeleta Rios, Ana Milena

    2017-01-01

    Las economías mundiales en proceso de recuperación, con grandes fábricas y una dotación mano de obra altamente productiva, demandaban del mercado un mayor nivel de consumo. Este entorno propició el cambio de foco económico hacia una sociedad de consumo. En este escenario se desarrolla la Obsolescencia Programada como una saludable insatisfacción en cuanto a hacer las cosas menos bien de lo que pueden hacerse con la intención de aumentar la rotación de los productos en mano de los consumidores...

  10. Vite et bien 1 A1/A2 : méthode rapide pour adultes

    CERN Document Server

    Miquel, Claire

    2009-01-01

    Vite et bien s'adresse à des adultes pressés et impatients de communiquer avec succès en français ! Le vocabulaire est simple et usuel et les thèmes, variés, pour faire face, efficacement, à toutes les situations de la vie quotidienne et professionnelle. Livre + CD audio et corrigés inclus. La méthode rapide Vite et bien 1 permet à la fois d'apprendre le français et de découvrir la réalité de la vie en France, les différences culturelles, le langage de la vie quotidienne, le tout en un temps record. En effet, le premier volume couvre, en vingt unités, les niveaux A1 et A2 du Cadre Européen de référence (CECR). Ainsi, en 100 à 120 heures de cours selon les publics, il sera possible d'acquérir une bonne base de grammaire et de vocabulaire, claire, simple, fonctionnelle, et de se sentir à l'aise dans la communication orale et écrite. L'ouvrage s'adresse aux vrais et et aux faux débutants, constituant donc un outil d'apprentissage et/ou de rafraîchissement des connaissances. Chacune des v...

  11. RNA-Seq analysis reveals insight into enhanced rice Xa7-mediated bacterial blight resistance at high temperature.

    Directory of Open Access Journals (Sweden)

    Stephen P Cohen

    Full Text Available Plant disease is a major challenge to agriculture worldwide, and it is exacerbated by abiotic environmental factors. During some plant-pathogen interactions, heat stress allows pathogens to overcome host resistance, a phenomenon which could severely impact crop productivity considering the global warming trends associated with climate change. Despite the importance of this phenomenon, little is known about the underlying molecular mechanisms. To better understand host plant responses during simultaneous heat and pathogen stress, we conducted a transcriptomics experiment for rice plants (cultivar IRBB61 containing Xa7, a bacterial blight disease resistance (R gene, that were infected with Xanthomonas oryzae, the bacterial blight pathogen of rice, during high temperature stress. Xa7-mediated resistance is unusual relative to resistance mediated by other R genes in that it functions better at high temperatures. Using RNA-Seq technology, we identified 8,499 differentially expressed genes as temperature responsive in rice cultivar IRBB61 experiencing susceptible and resistant interactions across three time points. Notably, genes in the plant hormone abscisic acid biosynthesis and response pathways were up-regulated by high temperature in both mock-treated plants and plants experiencing a susceptible interaction and were suppressed by high temperature in plants exhibiting Xa7-mediated resistance. Genes responsive to salicylic acid, an important plant hormone for disease resistance, were down-regulated by high temperature during both the susceptible and resistant interactions, suggesting that enhanced Xa7-mediated resistance at high temperature is not dependent on salicylic acid signaling. A DNA sequence motif similar to known abscisic acid-responsive cis-regulatory elements was identified in the promoter region upstream of genes up-regulated in susceptible but down-regulated in resistant interactions. The results of our study suggest that the plant

  12. The global warming, public goods and carbon market; Calentamiento global, bienes publicos y mercado de carbono

    Energy Technology Data Exchange (ETDEWEB)

    Quadri de la Torre, Gabriel [EcoSecurities (Mexico)

    2007-07-15

    The global warming is an issue of the public goods, and demands an outstanding multilateral action, which must to ensure both efficiency and unchanging transition towards an economy of low intensity of carbon. The new system, which is going to replace the Kyoto Protocol, will have compromises for the developing countries and deep implication in the relative competitivity of the nations and companies. [Spanish] El calentamiento global es un problema de bienes publicos que exige una extraordinaria accion multilateral. Esta debe asegurar eficiencia y una transicion fluida hacia una economia de baja intensidad de carbono. El nuevo sistema que sucedera al Protocolo de Kyoto significara compromisos para los paises en vias de desarrollo, y tendra profundas implicaciones en la competitividad relativa de naciones y empresas.

  13. Bienestar subjetivo, renta y bienes relacionales. Los determinantes de la felicidad en España

    Directory of Open Access Journals (Sweden)

    Iglesias Vázquez, Emma

    2013-12-01

    Full Text Available In the present paper we analyze the determinants of happiness proxying by subjective welfare. The main objective is twofold: on the one hand, to put to the test the Easterlin’s paradox (the lack of a direct relationship between income and subjective wellbeing at aggregate level and, on the other hand, to weight influence of relational goods in determining happiness. The analytical framework adopts the perspective of happiness economics and the empirical evidence is derived from the estimation of a microeconometric function of happiness applying a Logit model both when using cross sectional and panel data. The results show that in Spanish society income plays a secondary and subjective role, while other variables that are associated directly or indirectly to relational goods are revealed to be very important.En el presente trabajo se analizan los determinantes de la felicidad, entendida esta como satisfacción subjetiva revelada. El principal objetivo tiene un doble componente: por un lado, se trata de contrastar la paradoja de Easterlin para la sociedad española (ausencia de un vínculo directo entre el incremento de la renta per capita y la evolución del bienestar subjetivo revelado a nivel agregado y, por otro, evaluar el papel que desempeñan los bienes relacionales como determinantes de la felicidad. El marco analítico adoptado se encuadra dentro de la denominada happiness economics y la evidencia empírica se deriva de la estimación de una función microeconométrica de la felicidad aplicando un modelo Logit tanto en cortes temporales como en datos de panel. Los resultados obtenidos permiten concluir que en España el ingreso desempeña un papel secundario y subjetivo, mientras que se revelan como importantes las variables asociadas directa o indirectamente a los bienes relacionales.

  14. Codicia y bien público: los ministros de la Audiencia en la Lima seiscentista

    Directory of Open Access Journals (Sweden)

    de la Puente Brunke, José

    2006-04-01

    Full Text Available The Administration agent was a complex figure in Colonial Peru. This article aims to discuss that complexity, focusing its analysis on the Ministers of Lima’s Audiencia during the Seventeenth century. The concepts of greed (codicia and public good (bien público will be considered in that context, posing some ideas concerning the peculiar way of «selling» judicial posts, known as beneficio. The activities of some of the Audiencia’s Ministers in Lima will be discussed, trying to offer more references on their role in the viceregal society, as well as on their contemporaries’ perception regarding them.

    El presente artículo pretende ofrecer una visión de la complejidad de la figura del agente de la administración pública en el Perú virreinal, centrando su análisis en los ministros de la Audiencia de Lima en el siglo XVII. Como punto de partida, se presentan testimonios a través de los cuales se percibe la tensión entre la «codicia» y el «bien público», y en ese contexto se plantean algunas reflexiones sobre el beneficio de oficios de justicia. Luego se analizan las actividades de algunos de esos ministros en la Lima de entonces, y se busca ofrecer mayores referencias con respecto a su papel en la sociedad virreinal, y en cuanto a la visión que sobre ellos tenían sus contemporáneos.

  15. Thrombin and factor Xa link the coagulation system with liver fibrosis.

    Science.gov (United States)

    Dhar, Ameet; Sadiq, Fouzia; Anstee, Quentin M; Levene, Adam P; Goldin, Robert D; Thursz, Mark R

    2018-05-08

    Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent model of hepatic fibrosis. HSC-LX2 cells were incubated with FXa and/or thrombin in cell culture, stained for αSMA and relative gene expression and gel contraction calculated. C57BL/6 J mice were administered thioacetamide (TAA) for 8 weeks with Rivaroxaban (n = 15) or Dabigatran (n = 15). Control animals received TAA alone (n = 15). Fibrosis was scored and quantified using digital image analysis and hepatic tissue hydroxyproline estimated. Stellate cells treated with FXa and thrombin demonstrated upregulation of procollagen, TGF-beta, αSMA and significant cell contraction (43.48%+/- 4.12) compared to culturing with FXa or thrombin alone (26.90%+/- 8.90, p = 0.02; 13.1%+/- 9.84, p < 0.001). Mean fibrosis score, percentage area of fibrosis and hepatic hydroxyproline content (2.46 vs 4.08, p = 0.008; 2.02% vs 3.76%, p = 0.012; 276.0 vs 651.3, p = 0.0001) were significantly reduced in mice treated with the FXa inhibitor compared to control mice. FXa inhibition was significantly more effective than thrombin inhibition in reducing percentage area of fibrosis and hepatic hydroxyproline content (2.02% vs 3.70%,p = 0.031; 276.0 vs 413.1,p = 0.001). FXa promotes stellate cell contractility and activation. Early inhibition of coagulation using a FXa inhibitor significantly reduces TAA induced murine liver fibrosis and may be a viable treatment for liver fibrosis in patients.

  16. Le paysage dans l’action publique : du patrimoine au bien commun

    Directory of Open Access Journals (Sweden)

    Anne Sgard

    2010-09-01

    Full Text Available Le paysage est dorénavant partie prenante des politiques publiques locales, souvent affiché au cœur même du projet de territoire. Cependant le débat reste largement ouvert dès lors qu’il s’agit de préciser à quoi « sert le paysage » et de lui associer une/des valeurs particulières, susceptibles de porter et de légitimer la problématique paysagère au cours du montage du projet. Ce texte part du constat que deux termes sont de manière récurrente associés au paysage, le patrimoine et, plus récemment, le bien commun, et se propose d’interroger cette orientation du discours sur le paysage. La pratique et le cadre juridique français, tendent à enfermer le paysage dans un registre avant tout patrimonial, privilégiant une logique de protection. L’expression de bien commun pose question : est-ce un équivalent de patrimoine, une facilité de langage portée par la mode, ou un apport innovant qui permet de réinterroger la place du paysage dans le débat et les méthodes d’intervention? Revenant sur les cadres théoriques de la réflexion sur les biens communs et sur sa diffusion actuelle dans l’ensemble des sciences sociales et environnementales, ce texte cherchera à identifier ce qu’elle peut apporter à la compréhension de la place du paysage dans les projets, en mettant notamment l’accent sur la question de l’accessibilité et de la négociation.The landscape is now part of local public policies, often displayed at the very heart of territorial projects. But the debate remains wide open when it comes to specifying what should be the use of “landscape" and to determine with which particular value, in order to legitimize the thematic of landscape in the building of the territorial project. This text is based on the observation that two notions are consistently associated with landscape: heritage and, more recently, common good. We propose to examine the effect of these notions on the contemporary discourses

  17. Valuación de Bienes de Uso en el Marco de las Nuevas Normas Contables Profesionales

    Directory of Open Access Journals (Sweden)

    Beatriz Brozzú

    2005-12-01

    Full Text Available Respecto a la valuación de los Bienes de Uso el abandono de los valores corrientes, reemplazado por valores históricos, sacrifica los requisitos de aproximación a la realidad, verificabilidad y confiabilidad de la información. Al mismo tiempo, se contradice con Normas Internacionales de Contabilidad (IAS hacia las que supuestamente buscaba armonizar, ya que éstas (IAS 16 admiten revalorizaciones y desvalorizaciones, con énfasis en mostrar, en todo momento, el fair value de los Bienes de Uso.

  18. ENAJENACIÓN DE BIENES COMUNALES Y COLONIZACIÓN RURAL EN REQUENA. SIGLO XVIII

    Directory of Open Access Journals (Sweden)

    Juan Piqueras Haba

    2010-01-01

    Full Text Available Durante el siglo XVIII tuvo lugar en el municipio de Requena un proceso de colonización agraria por establecimiento de familias sobre unos territorios hasta entonces prácticamente deshabitados. El poblamiento y la misma colonización fue hecha a expensas de los bienes omunales, dehesas y montes blancos, gestionados por el Concejo de la villa de Requena, cuyos responsables no sólo malvendieron y toleraron la usurpación particular de los terrenos oncejiles, sino que fueron parte interesada en la misma, hasta el punto de acaparar la mayor parte de las tierras baldías. Al mismo tiempo el reparto, la enajenación y la adquisición de las dehesas concejiles por varias docenas de colonos dieron origen a que sobre aquellas fértiles tierras se desarrollaran luego muchas de las aldeas que hoy componen el paisaje rural del término. En menos de un siglo el ayuntamiento quedó privado de más de 60.000 hectáreas, de las que unas 20.000 fueron ganadas para la agricultura por colonos labradores cuyo número aumentó de sólo 80 en 1667 a 161 en 1731 y a 752 en 1831.

  19. Comercio intraindustrial Colombia-Estados Unidos. El caso de los bienes altamente tecnológicos

    Directory of Open Access Journals (Sweden)

    Mora Rodríguez Jhon James

    2011-09-01

    Full Text Available
    Este trabajo analiza el comercio intraindustrial entre Colombia y Estados Unidos entre 1995 y 2005,
    a partir de los datos de BACI (Base pour l’Analyse du Commerce International. En este período,
    9%de los productos que se comercializaron con Estados Unidos correspondieron a comercio
    intraindustrial, y parte de ellos fueron bienes altamente tecnológicos, según la categorización de la
    OECD. El índice de comercio intraindustrial pasó de 6 en 1995 a 23 en 2005 y utilizando pruebas
    de multimodalidad se encuentra que el índice G&L presenta más de una moda, lo cual podría ser el
    resultado de mercados segmentados o múltiples equilibrios, dada la existencia de economías de
    escala en sectores tecnológicamente sofisticados y del aprendizaje en la práctica

  20. De las cenizas a la Red: el Periodismo como bien común

    Directory of Open Access Journals (Sweden)

    José Carlos Sendín Gutiérrez

    2014-11-01

    Full Text Available Sampedro nos ofrece y comparte –porque el libro se puede leer en partes también en la red– no sólo y fundamentalmente un alegato a favor del periodismo, sino además, una defensa de un nuevo poder ciudadano y de una nueva democracia. Desde las primeras líneas el lector se siente sacudido por el alto voltaje de los datos, los personajes y el análisis perspicaz de la transformación social que parece apuntarse, pero que hasta ahora nadie había sabido traducir en palabras. Palabras que a veces parecen querer levantar por las solapas al que lee, como diciendo, “entérate, está pasando ahora y es importante que lo descubras”, mientras desarrolla ideas a las que vuelve y recalca, pasados los capítulos, en un ejercicio circular que pretende dejar clara –y lo consigue– la tesis central: ya existe una nueva forma de periodismo entendido como bien común (sí, al igual que el agua o el aire que respiramos, libre, de código abierto y mancomunado. Aire nuevo para una sociedad desencantada, para un periodismo en busca de modelos y para unas aulas donde se forman los futuros profesionales en una universidad maltratada, pero quizá por ello, también sumida en la conformidad de un saber rutinario.

  1. Bien faire un cours, un exposé, une conférence

    CERN Document Server

    Brown, George

    1981-01-01

    Le livre de Georges Brown est un livre important pour deux raisons : - Parce qu'il propose à tous les formateurs et enseignants une approche méthodologique de la transmission orale des connaissances. En effet, il ne suffit pas de bien connaître son sujet pour le faire comprendre à son auditoire. Ce livre est conçu pour mener le lecteur pas à pas dans la découverte de son propre style d'explication, de ses points faibles et de ses points forts. - Parce qu'il permet au lecteur, grâce à la pratique des 45 exercices contenus dans l'ouvrage, de faire alterner la réflexion et la performance individuelle avec l'échange d'expériences et l'auto-évaluation des méthodes d'enseignement oral. Ce livre, qui possède toutes les qualités du pragmatisme anglo-saxon, met au service de la formation un outil essentiellement pratique. Il s'adresse donc à tous ceux qui donnent des cours, font des séminaires,ou ont à exposer leurs idées devant un auditoire. EXPLIQUER, C'EST D'ABORD SAVOIR COMMUNIQUER.

  2. TTIP: Análisis jurídico-técnico y su impacto en el comercio de bienes

    OpenAIRE

    Aizpiri Oliván, Martín

    2016-01-01

    El TFG en cuestión trata de abordar desde una perspectiva técnico-jurídica los elementos y procedimientos para liberalizar el comercio que se plantean en el TTIP, con especial mención al comercio de bienes.

  3. Analysis of nucleotide diversity among alleles of the major bacterial blight resistance gene Xa27 in cultivars of rice (Oryza sativa) and its wild relatives.

    Science.gov (United States)

    Bimolata, Waikhom; Kumar, Anirudh; Sundaram, Raman Meenakshi; Laha, Gouri Shankar; Qureshi, Insaf Ahmed; Reddy, Gajjala Ashok; Ghazi, Irfan Ahmad

    2013-08-01

    Xa27 is one of the important R-genes, effective against bacterial blight disease of rice caused by Xanthomonas oryzae pv. oryzae (Xoo). Using natural population of Oryza, we analyzed the sequence variation in the functionally important domains of Xa27 across the Oryza species. DNA sequences of Xa27 alleles from 27 rice accessions revealed higher nucleotide diversity among the reported R-genes of rice. Sequence polymorphism analysis revealed synonymous and non-synonymous mutations in addition to a number of InDels in non-coding regions of the gene. High sequence variation was observed in the promoter region including the 5'UTR with 'π' value 0.00916 and 'θ w ' = 0.01785. Comparative analysis of the identified Xa27 alleles with that of IRBB27 and IR24 indicated the operation of both positive selection (Ka/Ks > 1) and neutral selection (Ka/Ks ≈ 0). The genetic distances of alleles of the gene from Oryza nivara were nearer to IRBB27 as compared to IR24. We also found the presence of conserved and null UPT (upregulated by transcriptional activator) box in the isolated alleles. Considerable amino acid polymorphism was localized in the trans-membrane domain for which the functional significance is yet to be elucidated. However, the absence of functional UPT box in all the alleles except IRBB27 suggests the maintenance of single resistant allele throughout the natural population.

  4. A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence.

    Science.gov (United States)

    Cyr, Normand; de la Fuente, Cynthia; Lecoq, Lauriane; Guendel, Irene; Chabot, Philippe R; Kehn-Hall, Kylene; Omichinski, James G

    2015-05-12

    Rift Valley fever virus (RVFV) is a single-stranded RNA virus capable of inducing fatal hemorrhagic fever in humans. A key component of RVFV virulence is its ability to form nuclear filaments through interactions between the viral nonstructural protein NSs and the host general transcription factor TFIIH. Here, we identify an interaction between a ΩXaV motif in NSs and the p62 subunit of TFIIH. This motif in NSs is similar to ΩXaV motifs found in nucleotide excision repair (NER) factors and transcription factors known to interact with p62. Structural and biophysical studies demonstrate that NSs binds to p62 in a similar manner as these other factors. Functional studies in RVFV-infected cells show that the ΩXaV motif is required for both nuclear filament formation and degradation of p62. Consistent with the fact that the RVFV can be distinguished from other Bunyaviridae-family viruses due to its ability to form nuclear filaments in infected cells, the motif is absent in the NSs proteins of other Bunyaviridae-family viruses. Taken together, our studies demonstrate that p62 binding to NSs through the ΩXaV motif is essential for degrading p62, forming nuclear filaments and enhancing RVFV virulence. In addition, these results show how the RVFV incorporates a simple motif into the NSs protein that enables it to functionally mimic host cell proteins that bind the p62 subunit of TFIIH.

  5. Treatment of proximal deep vein thrombosis with a novel synthetic compound (SR90107A/ORG31540) with pure anti-factor Xa activity - A phase II evaluation

    NARCIS (Netherlands)

    Buller, HR; Cariou, R; Gallus, A; Gent, M; Ginsberg, J; Prins, MH; Lensing, A; Levi, M; Nurmohammed, N; Hirsh, J; Roberts, R; ten Cate, JW; Decousus, H; Mismetti, P; Buchmuller, A; Charlet, [No Value; Viallon, A; van der Meer, J; Meinardi, [No Value; Meijer, K; Piovella, F; Barone, M; Beltrametti, C; Serafini, S; Kraaijenhagen, RA; Koopman, MMW; Jagt, HHT; Muller, MBR; Kooy, MV; Nauta, S; Gallus, AS; Coghlan, D; Rich, C; Prandoni, P; Scudeller, A; Scarano, L; Girolami, A; Baker, R; Tan, E; Cooney, J; Eikelboom, J; Ninet, J; Dolmazon, C; Madoux, MHG; Coppere, B; Nenci, GG; Agnelli, G; Falcinelli, F; Morini, M; d'Angelo, A

    2000-01-01

    Background-Patients with venous thromboembolism require initial treatment with an immediate-acting anticoagulant, low-molecular-weight heparin. We evaluated a novel synthetic factor Xa inhibitor (SR90107a/ORG31540) as an alternative treatment. Methods and Results-A randomized-parallel-group, phase

  6. Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

    Czech Academy of Sciences Publication Activity Database

    Calvo, E.; Mizurini, D.M.; Sa-Nunes, A.; Ribeiro, J.M.C.; Andersen, J. F.; Mans, B.J.; Monteiro, R.Q.; Kotsyfakis, Michalis; Francischetti, I.M.B.

    2011-01-01

    Roč. 286, č. 32 (2011), 27998-28010 ISSN 0021-9258 Institutional research plan: CEZ:AV0Z60220518 Keywords : serpin * mosquito * Aedes albopictus * phospholipids * Factor Xa * heparin * binding affinity * coagulation * thrombus * bleeding Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 4.773, year: 2011

  7. L2₁ and XA Ordering Competition in Hafnium-Based Full-Heusler Alloys Hf₂VZ (Z = Al, Ga, In, Tl, Si, Ge, Sn, Pb).

    Science.gov (United States)

    Wang, Xiaotian; Cheng, Zhenxiang; Wang, Wenhong

    2017-10-20

    For theoretical designing of full-Heusler based spintroinc materials, people have long believed in the so-called Site Preference Rule (SPR). Very recently, according to the SPR, there are several studies on XA-type Hafnium-based Heusler alloys X₂YZ, i.e., Hf₂VAl, Hf₂CoZ (Z = Ga, In) and Hf₂CrZ (Z = Al, Ga, In). In this work, a series of Hf₂-based Heusler alloys, Hf₂VZ (Z = Al, Ga, In, Tl, Si, Ge, Sn, Pb), were selected as targets to study the site preferences of their atoms by first-principle calculations. It has been found that all of them are likely to exhibit the L2₁-type structure instead of the XA one. Furthermore, we reveal that the high values of spin-polarization of XA-type Hf₂VZ (Z = Al, Ga, In, Tl, Si, Ge, Sn, Pb) alloys have dropped dramatically when they form the L2₁-type structure. Also, we prove that the electronic, magnetic, and physics nature of these alloys are quite different, depending on the L2₁-type or XA-type structures.

  8. Análise e identificação das antocianinas de couve rôxa (Brassica spp.)

    OpenAIRE

    Lopes, Dulce; Jesus, Benvinda; Cabrita, Luís

    2004-01-01

    A couve rôxa é uma espécie comestível com uma composição em antocianinas rica e complexa. Sabe-se que contem antocianinas poliglicosiladas, aciladas com um ou mesmo dois grupos acilo aromáticos, nomeadamente com ácidos coumárico e caféico. Este padrão de acilação é particularmente interessante, porque confere estabilidade às antocianinas e aumenta o seu potencial de utilização em aplicações famacêuticas, alimentares e cosméticas. Este estudo tem por objectivo determinar a...

  9. Tranexamic Acid Failed to Reverse the Anticoagulant Effect and Bleeding by an Oral Direct Factor Xa Inhibitor Edoxaban.

    Science.gov (United States)

    Honda, Yuko; Furugohri, Taketoshi; Morishima, Yoshiyuki

    2018-01-01

    Agents to reverse the anticoagulant effect of edoxaban, an oral direct factor Xa inhibitor, would be desirable in emergency situations. The aim of this study is to determine the effect of tranexamic acid, an antifibrinolytic agent, on the anticoagulant activity and bleeding by edoxaban in rats. A supratherapeutic dose of edoxaban (3 mg/kg) was intravenously administered to rats. Three minutes after dosing, tranexamic acid (100 mg/kg) was given intravenously. Bleeding was induced by making an incision with a blade on the planta 8 min after edoxaban injection and bleeding time was measured. Prothrombin time (PT) and clot lysis were examined. A supratherapeutic dose of edoxaban significantly prolonged PT and bleeding time. Tranexamic acid did not affect PT or bleeding time prolonged by edoxaban, although tranexamic acid significantly inhibited clot lysis in rat plasma. An antifibrinolytic agent tranexamic acid failed to reverse the anticoagulant effect and bleeding by edoxaban in rats. © 2017 S. Karger AG, Basel.

  10. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    Directory of Open Access Journals (Sweden)

    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value

  11. Problemática sobre la disponibilidad de los Bienes Jurídicos Individuales y Responsabilidades Emergentes

    Directory of Open Access Journals (Sweden)

    Ignacio Curbelo Solari

    2013-12-01

    Full Text Available Sobre el concepto de Disponibilidad. Concepto de Bien Jurídico y sus funciones. El Consentimiento. Breve Historia. Bienes Jurídicos Colectivos e Individuales. Naturaleza Jurídica del Consentimiento. Posición de Jescheck, Roxin y Muñoz Conde. Posición de los principales autores nacionales: Prof. Gonzalo Fernández, Miguel Langón, Germán Aller, Pedro Montano. Los requisitos del consentimiento. En la doctrina extranjeraEn la doctrina uruguaya El consentimiento presunto. Requisitos del consentimiento presunto.Relevancia del consentimiento en el Derecho Positivo. Derecho extranjero Derecho Uruguayo. Diversas situaciones. El art. 44 del CP. La Vida. El consentimiento y la responsabilidad de los médicos. Las intervenciones transexuales. La Eutanasia La ley 18.473 de Voluntad anticipada. La auto puesta en peligro.

  12. EL DILEMA DE LA CONTRIBUCIÓN VOLUNTARIA A BIENES PÚBLICOS: UNA REVISIÓN DE TRABAJOS EXPERIMENTALES

    Directory of Open Access Journals (Sweden)

    Luis Alejandro Palacio García

    2014-01-01

    Full Text Available El artículo presenta una revisión de los experimentos realizados sobre bienes públicos apoyados en el mecanismo de contribución voluntaria. La evidencia empírica existente muestra que los individuos no son solo los seres egoístas y competitivos que supone la teoría económica ortodoxa, sino que también son seres bondadosos y altruistas. Aunque los diversos trabajos experimentales concuerdan en la existencia de estos sentimientos catalogados como "bondad", no es claro si los sujetos actúan así para mejorar el bienestar de los demás (altruismo o porque se sienten bien realizando este tipo acciones (satisfacción moral.

  13. Ética de la convivencia en organizaciones del presente: Base fundamental para alcanzar el bien común

    Directory of Open Access Journals (Sweden)

    Cristina Seijo

    2014-01-01

    Full Text Available El propósito de esta investigación es establecer algunas consideraciones teóricas sobre la ética de la convivencia en las organizaciones de presente, de manera que la gerencia en estas organizaciones se perfile hacia la búsqueda del bien común, en este sentido, el estudio se basa en una metodología cualitativa, de tipo descriptiva y diseño no experimental, mediante un análisis documental, ubicada dentro del área de las Ciencias Sociales.En este sentido, el logro del bien común está asociado a alcanzar una vida en convivencia, esto significa lograr acuerdos mínimos a través del diálogo entre los ciudadanos de manera que se pueda establecer el respeto hacia el otro. La base de tales acuerdos será, necesariamente, la búsqueda del bienestar de la sociedad, es decir, el bien común. Esta idea justifica la necesidad de una ética común, la que conlleva al reconocimiento del otro, aceptar el bienestar del otro, aceptación del otro en nuestro sistema, para lograr la convivencia y alcanzar el bienestar o bien común.Palabras Clave: Ética de la convivencia; bien común; acuerdos mínimos. Ethics of the Living together in organizations of future: fundamental Base to reach the common goodAbstractThis research aims at advancing concepts regarding fellowship ethics in contemporary organizations, in order to organize management around common good practices. The achievement of the common good is thus associated to reaching fellowship, this is to achieve minimal consensus through dialog between citizens and strengthen respect to each other. The base of such consensus will be, necessarily, societal welfare, that is to say, the common good.Keywords: Ethics of the living; common good; minimal agreements.

  14. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome

    DEFF Research Database (Denmark)

    Steg, Ph Gabriel; Mehta, Shamir R; Jukema, J Wouter

    2011-01-01

    To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS)....

  15. Transgenic expression of the rice Xa21 pattern-recognition receptor in banana (Musa sp.) confers resistance to Xanthomonas campestris pv. musacearum.

    Science.gov (United States)

    Tripathi, Jaindra N; Lorenzen, Jim; Bahar, Ofir; Ronald, Pamela; Tripathi, Leena

    2014-08-01

    Banana Xanthomonas wilt (BXW), caused by the bacterium Xanthomonas campestris pv. musacearum (Xcm), is the most devastating disease of banana in east and central Africa. The spread of BXW threatens the livelihood of millions of African farmers who depend on banana for food security and income. There are no commercial chemicals, biocontrol agents or resistant cultivars available to control BXW. Here, we take advantage of the robust resistance conferred by the rice pattern-recognition receptor (PRR), XA21, to the rice pathogen Xanthomonas oryzae pv. oryzae (Xoo). We identified a set of genes required for activation of Xa21-mediated immunity (rax) that were conserved in both Xoo and Xcm. Based on the conservation, we hypothesized that intergeneric transfer of Xa21 would confer resistance to Xcm. We evaluated 25 transgenic lines of the banana cultivar 'Gonja manjaya' (AAB) using a rapid bioassay and 12 transgenic lines in the glasshouse for resistance against Xcm. About 50% of the transgenic lines showed complete resistance to Xcm in both assays. In contrast, all of the nontransgenic control plants showed severe symptoms that progressed to complete wilting. These results indicate that the constitutive expression of the rice Xa21 gene in banana results in enhanced resistance against Xcm. Furthermore, this work demonstrates the feasibility of PRR gene transfer between monocotyledonous species and provides a valuable new tool for controlling the BXW pandemic of banana, a staple food for 100 million people in east Africa. © 2014 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  16. Anticoagulant effects of inhaled unfractionated heparin in the dog as determined by partial thromboplastin time and factor Xa activity.

    Science.gov (United States)

    Manion, Jill S; Thomason, John M; Langston, Vernon C; Claude, Andrew K; Brooks, Marjory B; Mackin, Andrew J; Lunsford, Kari V

    2016-01-01

    To evaluate the anticoagulant effects of inhaled heparin in dogs. This study was conducted in 3 phases. In phase 1, bronchoalveolar lavage fluid (BALf) was collected to generate an in vitro calibration curve to relate heparin concentration to the activated partial thromboplastin time (aPTT). In phase 2, heparin was administered via nebulization to determine the threshold dose needed to prolong systemic aPTT. In phase 3, the local anticoagulant activity of inhaled heparin was determined by measurement of BALf anti-Xa activity and aPTT. University teaching hospital. Six healthy intact female Walker Hounds were used in this study. Two dogs were used for each phase. Inhaled unfractionated sodium heparin was administered in doses ranging from 50,000 to 200,000 IU. In vitro addition of heparin to BALf caused a prolongation in aPTT. Inhaled heparin at doses as high as 200,000 IU failed to prolong systemic aPTT, and a threshold dose could not be determined. No significant local anticoagulant effects were detected. Even at doses higher than those known to be effective in people, inhaled heparin appears to have no detectable local or systemic anticoagulant effects in dogs with the current delivery method. © Veterinary Emergency and Critical Care Society 2015.

  17. Retos para la política ambiental: el debate internacional sobre el comercio de bienes y servicios ambientales

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Martínez Ballesteros

    2006-11-01

    Full Text Available Los lineamientos de la actual política ambiental nacional enfatizan la promoción y el aprovechamiento sostenible de bienes y servicios ambientales. A nivel internacional, el tema se está tratando en la Organización Mundial del Comercio, por el mandato de la Declaración Ministerial de Doha (2001. Así mismo, se encuentra tácitamente en la actual agenda del desarrollo. El debate ha girado alrededor de lograr un acuerdo sobre definiciones y criterios de bienes y servicios ambientales para el comercio. Se ha mantenido una visión restringida sobre estos ítems, que excluye apreciaciones integrales desde la economía ambiental. Los bienes y servicios relacionados con la biodiversidad y los que proporcionan los ecosistemas, que podrían interesar a los países ‘megadiversos’ como Colombia no ocupan el centro del debate. La ausencia y la pasividad en este debate pueden conllevar a la pérdida de beneficios y oportunidades de la utilización sostenible de los recursos naturales, en contravía con la intención de la actual política ambiental. Así mismo, los resultados que se logren en la OMC tendrán repercusiones en otros tratados comerciales bilaterales o regionales que celebre el país y en el nivel de autonomía sobre el control de recursos naturales estratégicos.

  18. Retos para la política ambiental: el debate internacional sobre el comercio de bienes y servicios ambientales

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Martínez Ballesteros

    2006-01-01

    Full Text Available Los lineamientos de la actual política ambiental nacional enfatizan la promoción y el aprovechamiento sostenible de bienes y servicios ambientales. A nivel internacional, el tema se está tratando en la Organización Mundial del Comercio, por el mandato de la Declaración Ministerial de Doha (2001. Así mismo, se encuentra tácitamente en la actual agenda del desarrollo. El debate ha girado alrededor de lograr un acuerdo sobre definiciones y criterios de bienes y servicios ambientales para el comercio. Se ha mantenido una visión restringida sobre estos ítems, que excluye apreciaciones integrales desde la economía ambiental. Los bienes y servicios relacionados con la biodiversidad y los que proporcionan los ecosistemas, que podrían interesar a los países ‘megadiversos’ como Colombia no ocupan el centro del debate. La ausencia y la pasividad en este debate pueden conllevar a la pérdida de beneficios y oportunidades de la utilización sostenible de los recursos naturales, en contravía con la intención de la actual política ambiental. Así mismo, los resultados que se logren en la OMC tendrán repercusiones en otros tratados comerciales bilaterales o regionales que celebre el país y en el nivel de autonomía sobre el control de recursos naturales estratégicos

  19. Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity.

    Directory of Open Access Journals (Sweden)

    Maitreyee Sharma

    Full Text Available In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques. The purified protein, named daboxin P accounts for ~24% of the total protein of the crude venom and has a molecular mass of 13.597 kDa. It exhibits strong anticoagulant and phospholipase A2 activity but is devoid of any cytotoxic effect on the tested normal or cancerous cell lines. Its primary structure was deduced by N-terminal sequencing and chemical cleavage using Edman degradation and tandem mass spectrometry. It is composed of 121 amino acids with 14 cysteine residues and catalytically active His48 -Asp49 pair. The secondary structure of daboxin P constitutes 42.73% of α-helix and 12.36% of β-sheet. It is found to be stable at acidic (pH 3.0 and neutral pH (pH 7.0 and has a Tm value of 71.59 ± 0.46°C. Daboxin P exhibits anticoagulant effect under in-vitro and in-vivo conditions. It does not inhibit the catalytic activity of the serine proteases but inhibits the activation of factor X to factor Xa by the tenase complexes both in the presence and absence of phospholipids. It also inhibits the tenase complexes when active site residue (His48 was alkylated suggesting its non-enzymatic mode of anticoagulant activity. Moreover, it also inhibits prothrombinase complex when pre-incubated with factor Xa prior to factor Va addition. Fluorescence emission spectroscopy and affinity chromatography suggest the probable interaction of daboxin P with factor X and factor Xa. Molecular docking analysis reveals the interaction of the Ca+2 binding loop; helix C; anticoagulant region and C-terminal region of daboxin P with the heavy chain of factor Xa. This is the first report of a phospholipase A2 enzyme from Indian viper venom which targets both factor X and factor Xa for its anticoagulant activity.

  20. Gestión de bienes patrimoniales y control interno en el Ministerio de Agricultura y Riego - 2015

    OpenAIRE

    Zanabria Cárdenas, Luisa

    2017-01-01

    La presente investigación tuvo como objetivo general determinar la relación que existe entre la gestión de bienes patrimoniales y el control interno en el Ministerio de Agricultura y Riego, Lima, 2015. La población o universo de interés en esta investigación, estuvo conformada por los trabajadores administrativos de la Oficina General de Administración del Ministerio de Agricultura y Riego, la muestra estuvo constituida por 30 trabajadores del personal que se encuentran pres...

  1. La importancia de los bienes públicos en la calidad de vida local: El caso de Manizales, Colombia

    OpenAIRE

    Velasquez, Liliana

    2011-01-01

    Este documento aplica un método diseñado por el BID para el monitoreo de la calidad urbana que se basa en la combinación de dos enfoques: precios hedónicos y satisfacción con la vida. Esta combinación permite efectuar una valoración de los bienes públicos locales tanto desde el punto de vista del mercado como de la utilidad. A diferencia de otros sistemas de monitoreo, éste se concentra en pocas dimensiones (aquellas relacionadas con la habitabilidad del entorno urbano) y ofrece información v...

  2. Retos para la política ambiental: el debate internacional sobre el comercio de bienes y servicios ambientales

    OpenAIRE

    Diego Alejandro Martínez Ballesteros

    2006-01-01

    Los lineamientos de la actual política ambiental nacional enfatizan la promoción y el aprovechamiento sostenible de bienes y servicios ambientales. A nivel internacional, el tema se está tratando en la Organización Mundial del Comercio, por el mandato de la Declaración Ministerial de Doha (2001). Así mismo, se encuentra tácitamente en la actual agenda del desarrollo. El debate ha girado alrededor de lograr un acuerdo sobre definiciones y ...

  3. Ingénierie de la maintenance De la conception à l'exploitation d'un bien

    CERN Document Server

    Francastel, Jean-Claude

    2003-01-01

    La maintenance a évolué : d’abord confinée à l’entretien des équipements “réparer“ les pannes puis élargie à leur surveillance “prévoir” les pannes elle est intégrée aujourd’hui dès la phase de conception du produit avec notamment le concept de “maintenabilité” du produit. L’ingénierie de maintenance désigne ce processus d’accompagnement d’un bien industriel durant toutes les phases de son cycle de vie de la conception au démantèlement qui permet d’optimiser l’exploitation de ce bien et son coût global life cycle cost. Cet ouvrage décrit les différentes phases du cycle de vie en exposant les techniques qui permettent d’intégrer à chaque étape les concepts de maintenance.

  4. Tout va bien ! méthode de français : cahier d'exercices 2

    CERN Document Server

    Augé, H; Marlhens, C; Martin, L

    2005-01-01

    Tout va bien ! est une méthode de français destinée aux grands adolescents et adultes débutants ou faux-débutants. Ses objectifs respectent scrupuleusement les recommandations du Cadre européen commun de référence pour les langues, comme en témoigne le portfolio qui accompagne le livre de l'élève. Tout va bien ! propose : Des supports et des situations de communication authentiques ou proches de l'authentique, permettant à l'élève de se sensibiliser aux différents registres et de découvrir certains aspects de la culture francophone tout autant que la langue. De très nombreuses activités visant l'acquisition des quatre compétences de communication et l'utilisation de stratégies spécifiques. Un travail sur la grammaire et le vocabulaire associés aux situations et au service de la communication faisant une large place à l'observation et à la réflexion. Une invitation régulière à l'évaluation, au travail an autonomie et à l'auto-évaluation.

  5. Tout va bien ! méthode de français : cahier d'exercices 1

    CERN Document Server

    Augé, H; Marlhens, C; Martin, L

    2005-01-01

    Tout va bien ! est une méthode de français destinée aux grands adolescents et adultes débutants ou faux-débutants. Ses objectifs respectent scrupuleusement les recommandations du Cadre européen commun de référence pour les langues, comme en témoigne le portfolio qui accompagne le livre de l'élève. Tout va bien ! propose : Des supports et des situations de communication authentiques ou proches de l'authentique, permettant à l'élève de se sensibiliser aux différents registres et de découvrir certains aspects de la culture francophone tout autant que la langue. De très nombreuses activités visant l'acquisition des quatre compétences de communication et l'utilisation de stratégies spécifiques. Un travail sur la grammaire et le vocabulaire associés aux situations et au service de la communication faisant une large place à l'observation et à la réflexion. Une invitation régulière à l'évaluation, au travail an autonomie et à l'auto-évaluation.

  6. Anticoagulant activity in salivary glands of the insect vector Culicoides variipennis sonorensis by an inhibitor of factor Xa.

    Science.gov (United States)

    Pérez de León, A A; Valenzuela, J G; Tabachnick, W J

    1998-02-01

    Blood feeding by the insect vector Culicoides variipennis sonorensis involves laceration of superficial host tissues, an injury that would be expected to trigger the coagulation cascade. Accordingly, the salivary glands of C.v. sonorensis were examined for the presence of an antihemostatic that prevents blood coagulation. Assays using salivary gland extracts showed a delay in the recalcification time of plasma devoid of platelets, indicating the presence of anticoagulant activity. Retardation in the formation of a fibrin clot was also observed after the addition of tissue factor to plasma that was preincubated with salivary gland extracts. Similarly, an inhibitory effect by salivary gland extracts was detected in assays that included factors of the intrinsic pathway. Inhibition of the catalytic activity of purified factor Xa toward its chromogenic substrate suggested that it was the target of the salivary anticoagulant of C.v. sonorensis. This was corroborated by the coincidence of anticoagulant and anti-FXa activities obtained by reverse-phase HPLC. The depletion of anti-FXa activity from salivary glands during blood feeding suggests that the FXa inhibitor functions as anticoagulant. Molecular sieving HPLC yielded an apparent molecular mass of 28 kDa for the salivary FXa inhibitor of C.v. sonorensis. Preventing the formation of thrombin through the inhibition of FXa likely facilitates blood feeding by maintaining the pool of blood fluid at the feeding site. The salivary FXa inhibitor of C.v. sonorensis could impair the network of host-defense mechanisms in the skin microenvironment by avoiding blood coagulation at the site of feeding.

  7. De Bienes de la Nación a Monumentos nacionales : Romanticismo y Patrimonio arquitectónico en Portugal

    Directory of Open Access Journals (Sweden)

    María Helena Maia

    2006-01-01

    Full Text Available Este artículo trata de la construcción de la noción de Patrimonio Arquitectónico en Portugal entre 1825 y 1880, período elegido por corresponder con aquél donde se define y consolida el proyecto de preservación romántico. De este modo, a partir del problema generado por la integración en los Bienes de la Nación de la voluminosa masa de bienes muebles e inmuebles, los «bienes nacionales», que hasta entonces habían estado mayoritariamente en poder de las Ordenes Religiosas y que incluían un elevado porcentaje de aquello que hoy se considera el patrimonio nacional. Se procura no solo comprender la evolución del cuadro patrimonial, sino también la de los discursos sobre el tema, la legislación promulgada y las prácticas efectivas de definición y salvaguardia de ese conjunto de edificios que, en este período, con el desarrollo de la consciencia patrimonial, se transforman en Monumentos Nacionales.This paper deals with the construction of the notion of Architectural Heritage in Portugal between 1825 and 1880, when the romantic «preservation project» was defined and consolidated. Having as a starting point the problem generated by the integration in the property of the Nation of a voluminous mass of properties, the so-called «national properties», that had until then been in the ownership of Religious Orders and include a high percentage of what is today considered our national heritage, we try not only to understand the evolution of the constitution of our architectural heritage, but also the several speeches on the subject, the promulgated legislation and the existing practices of definition and safeguard of this set of buildings that, at this time and due to the development of the consciousness of our heritage, were turned into National Monuments.

  8. Política social, paradigma de bien estar y práctica política

    OpenAIRE

    David Martinez; Aloisio Ruscheinsky

    2010-01-01

    El artículo aborda la realidad de las des-igualdades y las políticas sociales orienta-das a la creación de mecanismos de bien-estar social. Estos procesos figuran como las tentativas de la superación de la pobre-za, se traducen en retos históricos situados en un contexto espacial de los conflictos entre los actores sociales. En este sentido, parecía a nosotros apropiado construir una exposición de algunos suportes teóri-cos de apoyo a la interpretación que ven-ían a amparar un análisis de las...

  9. Jean-Baptiste Comby (dir.), Enquêter sur l’internationalisation des biens médiatiques et culturels

    OpenAIRE

    Mouchard, Laure

    2018-01-01

    Issu de réflexions menées lors d’un séminaire du Centre d’analyse et de recherche interdisciplinaire sur les médias consacré à l’internationalisation des médias, l’ouvrage dirigé et introduit par Jean-Baptiste Comby prend le parti de « sociologiser » l’étude des phénomènes d’internationalisation des biens médiatiques et culturels, thème que l’auteur estime davantage investi par les historiens, les économistes, les politistes et les sémiologues. En faisant retour sur l’histoire des études de l...

  10. Trivial topological phase of CaAgP and the topological nodal-line transition in CaAg (P1 -xA sx)

    Science.gov (United States)

    Xu, N.; Qian, Y. T.; Wu, Q. S.; Autès, G.; Matt, C. E.; Lv, B. Q.; Yao, M. Y.; Strocov, V. N.; Pomjakushina, E.; Conder, K.; Plumb, N. C.; Radovic, M.; Yazyev, O. V.; Qian, T.; Ding, H.; Mesot, J.; Shi, M.

    2018-04-01

    By performing angle-resolved photoemission spectroscopy and first-principles calculations, we address the topological phase of CaAgP and investigate the topological phase transition in CaAg (P1 -xA sx) . We reveal that in CaAgP, the bulk band gap and surface states with a large bandwidth are topologically trivial, in agreement with hybrid density functional theory calculations. The calculations also indicate that application of "negative" hydrostatic pressure can transform trivial semiconducting CaAgP into an ideal topological nodal-line semimetal phase. The topological transition can be realized by partial isovalent P/As substitution at x =0.38 .

  11. Transport and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans at the Bien Hoa Agent Orange hotspot in Vietnam.

    Science.gov (United States)

    Van Thuong, Nguyen; Hung, Nguyen Xuan; Mo, Nguyen Thi; Thang, Nguyen Manh; Huy, Pham Quang; Van Binh, Hoang; Nam, Vu Duc; Van Thuy, Nguyen; Son, Le Ke; Minh, Nguyen Hung

    2015-10-01

    The Bien Hoa airbase (south of Vietnam) is known as one of the Agent Orange hotspots which have been seriously contaminated by Agent Orange/dioxin during the Vietnam War. Hundreds of samples including soil, sediment and fish were collected at the Bien Hoa Agent Orange hotspot for assessment of the environmental contamination caused by dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs). The toxicity equivalency quotient (TEQ) concentration of PCDD/Fs in soil and sediment varied from 7.6 to 962,000 and 17 to 4860 pg/g dry wt, respectively, implying very high contamination of PCDD/Fs in several areas. PCDD/F levels in fish ranged between 1.8 and 288 pg/g TEQ wet wt and was generally higher than advisory guidelines for food consumption. 2,3,7,8-Tetrachlorinated dibenzo-p-dioxins (2,3,7,8-TCDD) contributed 66-99 % of TEQ for most of the samples, suggesting 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) from Agent Orange as the major source of the contamination. The vertical transport of PCDD/Fs was observed in soil column with high TEQ levels above 1000 pg/g dry wt (Vietnamese limit for necessary remediation activities- TCVN 8183:2009 (2009)) even at a depth of 1.8 m. The vertical transport of PCDD/Fs has probably mainly taken place during the "Ranch Hand" defoliant spray activities due to the leaks and spills of phenoxy herbicides and solvents. The congener patterns suggest that transports of PCDD/Fs by weathering processes have led to their redistribution in the low-land areas. Also, an estimate for the total volume of contaminated soil requiring remediation to meet Vietnamese regulatory limits is provided.

  12. LA TEORÍA GENERAL DE LA TRASMISIÓN DE BIENES Y EL REGISTRO DE LA PROPIEDAD EN ESPAÑA

    Directory of Open Access Journals (Sweden)

    Joaquín Sánchez Cebrián

    2008-01-01

    Full Text Available La circulación de los bienes en el tráfico jurídico por la voluntad de los particulares es un tema crucial que interesa, no sólo a las partes del contrato, sino a todos en general, y en particular, a los acreedores del transmitente o del adquirente y a los terceros adquirentes de derechos sobre el bien. En este trabajo se analizará el régimen de trasmisión de los bienes por negocio inter vivos en el Derecho español, dentro del marco europeo, y con particular referencia a la trasmisión inmobiliaria. España adopta un peculiar sistema de trasmisión de lo bienes, porque se establecen reglas genéricas aplicables con independencia de la naturaleza mueble o inmueble del bien; y junto a ellas, se superponen otras que tratan de fijar los efectos de la publicidad registral inmobiliaria. La coordinación entre dichas reglas produce un original resultado, que puede constituir el punto de encuentro de los diversos sistemas registrales europeos.

  13. Determination of rivaroxaban in patient's plasma samples by anti-Xa chromogenic test associated to High Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS).

    Science.gov (United States)

    Derogis, Priscilla Bento Matos; Sanches, Livia Rentas; de Aranda, Valdir Fernandes; Colombini, Marjorie Paris; Mangueira, Cristóvão Luis Pitangueira; Katz, Marcelo; Faulhaber, Adriana Caschera Leme; Mendes, Claudio Ernesto Albers; Ferreira, Carlos Eduardo Dos Santos; França, Carolina Nunes; Guerra, João Carlos de Campos

    2017-01-01

    Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure rivaroxaban plasmatic concentration. Our method used a simple sample preparation, protein precipitation, and a fast chromatographic run. It was developed a precise and accurate method, with a linear range from 2 to 500 ng/mL, and a lower limit of quantification of 4 pg on column. The new method was compared to a reference method (anti-factor Xa activity) and both presented a good correlation (r = 0.98, p plasma samples for rivaroxaban measurement by HPLC-MS/MS without interferences. The chromogenic and HPLC-MS/MS methods were highly correlated and should be used as clinical tools for drug monitoring. The method was applied successfully in a group of 49 real-life patients, which allowed an accurate determination of rivaroxaban in peak and trough levels.

  14. Determination of rivaroxaban in patient’s plasma samples by anti-Xa chromogenic test associated to High Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS)

    Science.gov (United States)

    Derogis, Priscilla Bento Matos; Sanches, Livia Rentas; de Aranda, Valdir Fernandes; Colombini, Marjorie Paris; Mangueira, Cristóvão Luis Pitangueira; Katz, Marcelo; Faulhaber, Adriana Caschera Leme; Mendes, Claudio Ernesto Albers; Ferreira, Carlos Eduardo dos Santos; França, Carolina Nunes; Guerra, João Carlos de Campos

    2017-01-01

    Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure rivaroxaban plasmatic concentration. Our method used a simple sample preparation, protein precipitation, and a fast chromatographic run. It was developed a precise and accurate method, with a linear range from 2 to 500 ng/mL, and a lower limit of quantification of 4 pg on column. The new method was compared to a reference method (anti-factor Xa activity) and both presented a good correlation (r = 0.98, p highly correlated and should be used as clinical tools for drug monitoring. The method was applied successfully in a group of 49 real-life patients, which allowed an accurate determination of rivaroxaban in peak and trough levels. PMID:28170419

  15. Ingreso y bienes de la población de edad media y avanzada en México

    Directory of Open Access Journals (Sweden)

    Rebeca Wong

    2003-01-01

    Full Text Available El propósito de este artículo es resumir el monto y los tipos de ingreso que percibe y bienes que posee la población de edad media y avanzada en México. Se usan datos de la nueva Encuesta Nacional sobre Salud y Envejecimiento en México (Enasem 2001, un estudio prospectivo de panel con representación nacional de las personas de 50 años de edad y más. Los resultados confirman las hipótesis formuladas: la distribución del ingreso y la riqueza están sesgadas en favor de ciertos grupos, sobre todo aquéllos con mayor educación; la composición de la riqueza se da principalmente en forma no financiera y el apoyo familiar es una fuente de ingreso importante; la asociación entre riqueza y salud es positiva en general, lo cual es consistente con la literatura internacional. Además se encuentra que la riqueza acumulada está distribuida más equitativamente que el ingreso, y se concluye que el indicador de riqueza ofrece una dimensión de análisis adicional al ingreso, con potencial para contribuir a los estudios del bienestar de la población en edad media y avanzada en México.

  16. Ingreso y bienes de la población de edad media y avanzada en México*

    Science.gov (United States)

    Wong, Rebeca; Espinoza, Mónica

    2017-01-01

    Resumen El propósito de este artículo es resumir el monto y los tipos de ingreso que percibe y bienes que posee la población de edad media y avanzada en México. Se usan datos de la nueva Encuesta Nacional sobre Salud y Envejecimiento en México (Enasem) 2001, un estudio prospectivo de panel con representación nacional de las personas de 50 años de edad y más. Los resultados confirman las hipótesis formuladas: la distribución del ingreso y la riqueza están sesgadas en favor de ciertos grupos, sobre todo aquéllos con mayor educación; la composición de la riqueza se da principalmente en forma no financiera y el apoyo familiar es una fuente de ingreso importante; la asociación entre riqueza y salud es positiva en general, lo cual es consistente con la literatura internacional. Además se encuentra que la riqueza acumulada está distribuida más equitativamente que el ingreso, y se concluye que el indicador de riqueza ofrece una dimensión de análisis adicional al ingreso, con potencial para contribuir a los estudios del bienestar de la población en edad media y avanzada en México. PMID:29386981

  17. Variants, Layers of Authorial Intervention, and Texts in Lope de Vega’s La buena guarda and La encomienda bien guardada autograph manuscript

    Directory of Open Access Journals (Sweden)

    Stefania Capoia

    2014-01-01

    Full Text Available In this article I study, analyze and classify the variant readings and the different layers of authorial intervention that appear in Lope de Vega’s La buena guarda and La encomienda bien guardada manuscript. I contend that the second version of the work should be edited, a possibility thus far neglected by modern editors.

  18. Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study

    DEFF Research Database (Denmark)

    NN, NN

    2010-01-01

    BACKGROUND: Atrial fibrillation (AF), the most common significant cardiac arrhythmia, increases the risk of stroke, particularly in the elderly. Warfarin is effective in reducing stroke risk but is burdensome to patients and is difficult to control. Rivaroxaban is an oral direct factor Xa inhibit...

  19. Los bienes de las parroquias altoaragonesas en el Museo de Lérida : de sentencias e intenciones

    Directory of Open Access Journals (Sweden)

    María José Navarro Bometón

    2011-01-01

    Full Text Available En 1995, tras la reforma de los límites diocesanos entre las antiguas sedes episcopales de Lérida y Barbastro, se ponía en marcha un litigio canónico por la propiedad de los bienes artísticos procedentes de las parroquias altoaragonesas que, desde finales del siglo XIX, fueron trasladados al Museo del Seminario ilerdense, después Museo Diocesano. La Nunciatura Apostólica decretó en 1998 que las piezas estaban en Lérida a título de depósito y que la propiedad pertenecía a las parroquias que habían pasado a formar parte de la diócesis de Barbastro-Monzón. El litigio canónico se zanjó en 2007, pero actualmente las piezas protagonizan varias causas en los tribunales civiles, entre las que destacan las abiertas por dos ayuntamientos cuyas parroquias pertenecen, desde 1955, a la diócesis de Huesca. Algunos de los bienes en litigio tienen un notable valor artístico, pero es su valor como símbolo histórico y de identidad, como herencia del esfuerzo y de la devoción de unas comunidades rurales, lo que reclaman los aragoneses. Así mismo, las instituciones catalanas, abogan por la propiedad de unas piezas cuya conservación fue posible gracias a la labor del obispado de Lérida.In 1995 after the reform of the diocesan boundaries between the former Episcopal sees of Lérida and Barbastro a canonical dispute was initiated in order to establish the property of the artistic goods from the High Aragon, which at the end of the 19th century were moved to the Seminary Museum of Lerida, called afterwards Diocesan Museum. The Apostolic Nunciature decreed in 1998 that the pieces were in Lérida in storage and that they belonged to the parishes which had formed part of the diocese Barbastro- Monzón. The canonical dispute ended in 2007, but the pieces are involved presently in several civil court cases, among which are those opened by two councils whose parishes belong since 1955 to the Diocese of Huesca. Some of the historical and disputed

  20. Concepción del bien común en el pensamiento de Salvador Cisneros Betancourt: fundamento ético de un pensamiento político

    Directory of Open Access Journals (Sweden)

    Lic. Yudith Sotomayor-Gil

    2015-10-01

    Full Text Available Este trabajo se centra en el tratamiento teórico y desarrollo histórico de la categoría ética de bien común y su presencia, como fundamento, en el pensamiento político de Salvador Cisneros Betancourt, figura notoria y controversial de la historia de Cuba. Este tema, que se revela como continuidad de la tradición ética en que se sostiene el pensamiento cubano desde su momento fundacional, no ha recibido un tratamiento sistemático en la literatura filosófica cubana actual. El análisis de los documentos, en especial los que se inscriben entre 1902 y 1914, permite apreciar que, aunque no la aborde de forma explícita, la concepción del bien común permea el quehacer intelectual de Cisneros en esos años.

  1. “Jeneros de gusto y sobretodos ingleses”: el impacto cultural del consumo de bienes ingleses por la clase alta bogotana .

    Directory of Open Access Journals (Sweden)

    Ana Maria Otero Cleves.

    2009-05-01

    Full Text Available Este artículo analiza el impacto cultural del consumo de bienes Inglés por la clase alta de Bogotá durante el siglo XIX. Se sugiere que el consumo de productos Inglés después de la independencia del país fue uno de los principales mecanismos empleados por las clases altas para asegurar su posición social, así como para construir una nación moderna, de acuerdo a las normas europeas. Por lo tanto, el artículo analiza el papel que el consumo de bienes extranjeros en el proceso de construcción de la nación y la diferenciación social en el siglo XIX.

  2. La América Latina y El Caribe en 1913 y 1925. Enfoque desde las importaciones de bienes de capital

    Directory of Open Access Journals (Sweden)

    Xavier Tafunell

    2008-01-01

    Full Text Available En este artículo estudiamos el desarrollo económico alcanzado por la totalidad de los Estados latinoamericanos y caribeños soberanos en 1913 y 1925 desde una perspectiva inédita en el estudio del conjunto de la región: las importaciones y la producción –que sumadas equivalen al consumo aparente– de bienes de capital. Asegurada la fiabilidad de las estadísticas del comercio exterior, procedemos a reconstruir las magnitudes de los bienes de capital adquiridos por las 20 repúblicas. También estimamos la producción interna. La nueva evidencia empírica pone de manifiesto las enormes diferencias existentes en el seno de la región en el consumo per cápita de bienes de capital al término de la primera oleada globalizadora. La comparación entre los niveles de 1913 y 1925 revela que, en general, la contienda mundial no favoreció el proceso de sustitución de importaciones de la región, pero no en todos los países por igual.

  3. ¿Puede existir el bien común? El teorema de la imposibilidad de Arrow y la nueva democracia colombiana

    Directory of Open Access Journals (Sweden)

    Hugo López

    1991-07-01

    Full Text Available Colombia acaba de aprobar una nueva constitución. Es la expresión del ideal liberal: así como la apertura económica al aumentar el grado de competencia debe garantizar un suministro adecuado de bienes privados, se espera que una democracia más abierta y participativa que permita un mayor control de los ciudadanos sobre sus asuntos colectivos y asegure un suministro de bienes públicos más racional. Conviene recordar que este ideal se enfrentará a graves dificultades. El bien común no surge automáticamente de las elecciones. Las paradojas a las que estas están sometidas y el teorema de la imposibilidad de Arow, discutidos en este artículo así lo aprueban. La democracia es la expresión de Churchil- “la peor forma de gobierno- con excepción de todas las otras formas conocidas”. No carece entonces de dificultades. Está construida sobre la lógica del conflicto que pretende regular pero que no elimina en absoluto (la guerra civil es siempre una posibilidad virtual.

  4. Corrélats du bien-être chez les Canadiens présentant des troubles de l’humeur ou d'anxiété

    Directory of Open Access Journals (Sweden)

    H. Orpana

    2016-01-01

    Full Text Available Introduction : Notre objectif visait à étudier les variables liées au bien-être, mesurées par une autoévaluation de la santé mentale (AESM très positive et une satisfaction élevée à l’égard de la vie (SV chez des adultes canadiens (âgés de 18 ans et plus présentant un trouble de l’humeur ou d'anxiété. Méthodologie : Nous avons utilisé des données nationales représentatives tirées de l’Enquête sur les personnes ayant une maladie chronique au Canada – Composante des troubles de l’humeur et d’anxiété (EPMCC-TAH de 2014 afin de décrire l’association entre bien-être et comportements d’autogestion (activité physique, sommeil et méditation ainsi que stress, adaptation et soutien social perçus. Nous avons eu recours à une régression logistique multivariée pour modéliser la relation entre ces facteurs et les mesures du bien-être. Résultats : Environ une personne sur trois atteinte d’un trouble de l’humeur ou d’anxiété a fait état d'une AESM positive. Les modèles de régression logistique ont révélé que plusieurs caractéristiques, comme un âge plus avancé, une autoévaluation de la santé générale positive, des limitations fonctionnelles moins nombreuses ainsi que la perception d’un moindre stress à l’égard de la vie, de meilleures capacités d’adaptation et d’un plus grand soutien social, étaient associées à des niveaux de bien-être plus élevés. Les comportements d’autogestion (entamer une activité physique, méditer, adopter de saines habitudes de sommeil et atteindre un certain nombre d’heures de sommeil chaque nuit n’étaient pas significativement associés à des mesures du bien-être dans notre modèle multivarié. Conclusion : Les adultes canadiens souffrant de troubles de l’humeur ou d'anxiété qui ont déclaré percevoir un niveau de stress plus faible, un plus grand soutien social et une meilleure capacité d’adaptation étaient plus susceptibles de

  5. Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model.

    Directory of Open Access Journals (Sweden)

    Kazuya Hosokawa

    Full Text Available Dabigatran and rivaroxaban are novel oral anticoagulants that specifically inhibit thrombin and factor Xa, respectively. The aim of this study is to elucidate antithrombotic properties of these anticoagulant agents under arterial and venous shear conditions. Whole blood samples treated with dabigatran or rivaroxaban at 250, 500, and 1000 nM, with/without aspirin and AR-C66096, a P2Y12 antagonist, were perfused over a microchip coated with collagen and tissue thromboplastin at shear rates of 240 and 600 s(-1. Fibrin-rich platelet thrombus formation was quantified by monitoring flow pressure changes. Dabigatran at higher concentrations (500 and 1000 nM potently inhibited thrombus formation at both shear rates, whereas 1000 nM of rivaroxaban delayed, but did not completely inhibit, thrombus formation. Dual antiplatelet agents weakly suppressed thrombus formation at both shear rates, but intensified the anticoagulant effects of dabigatran and rivaroxaban. The anticoagulant effects of dabigatran and rivaroxaban were also evaluated under static conditions using thrombin generation (TG assay. In platelet-poor plasma, dabigatran at 250 and 500 nM efficiently prolonged the lag time (LT and moderately reduce peak height (PH of TG, whereas rivaroxaban at 250 nM efficiently prolonged LT and reduced PH of TG. In platelet-rich plasma, however, both anticoagulants efficiently delayed LT and reduced PH of TG. Our results suggest that dabigatran and rivaroxaban may exert distinct antithrombotic effects under flow conditions, particularly in combination with dual antiplatelet therapy.

  6. Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban-an oral, direct Factor Xa inhibitor.

    Science.gov (United States)

    Burghaus, Rolf; Coboeken, Katrin; Gaub, Thomas; Niederalt, Christoph; Sensse, Anke; Siegmund, Hans-Ulrich; Weiss, Wolfgang; Mueck, Wolfgang; Tanigawa, Takahiko; Lippert, Jörg

    2014-01-01

    The long-lasting anticoagulant effect of vitamin K antagonists can be problematic in cases of adverse drug reactions or when patients are switched to another anticoagulant therapy. The objective of this study was to examine in silico the anticoagulant effect of rivaroxaban, an oral, direct Factor Xa inhibitor, combined with the residual effect of discontinued warfarin. Our simulations were based on the recommended anticoagulant dosing regimen for stroke prevention in patients with atrial fibrillation. The effects of the combination of discontinued warfarin plus rivaroxaban were simulated using an extended version of a previously validated blood coagulation computer model. A strong synergistic effect of the two distinct mechanisms of action was observed in the first 2-3 days after warfarin discontinuation; thereafter, the effect was close to additive. Nomograms for the introduction of rivaroxaban therapy after warfarin discontinuation were derived for Caucasian and Japanese patients using safety and efficacy criteria described previously, together with the coagulation model. The findings of our study provide a mechanistic pharmacologic rationale for dosing schedules during the therapy switch from warfarin to rivaroxaban and support the switching strategies as outlined in the Summary of Product Characteristics and Prescribing Information for rivaroxaban.

  7. Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban—an oral, direct Factor Xa inhibitor

    Science.gov (United States)

    Burghaus, Rolf; Coboeken, Katrin; Gaub, Thomas; Niederalt, Christoph; Sensse, Anke; Siegmund, Hans-Ulrich; Weiss, Wolfgang; Mueck, Wolfgang; Tanigawa, Takahiko; Lippert, Jörg

    2014-01-01

    The long-lasting anticoagulant effect of vitamin K antagonists can be problematic in cases of adverse drug reactions or when patients are switched to another anticoagulant therapy. The objective of this study was to examine in silico the anticoagulant effect of rivaroxaban, an oral, direct Factor Xa inhibitor, combined with the residual effect of discontinued warfarin. Our simulations were based on the recommended anticoagulant dosing regimen for stroke prevention in patients with atrial fibrillation. The effects of the combination of discontinued warfarin plus rivaroxaban were simulated using an extended version of a previously validated blood coagulation computer model. A strong synergistic effect of the two distinct mechanisms of action was observed in the first 2–3 days after warfarin discontinuation; thereafter, the effect was close to additive. Nomograms for the introduction of rivaroxaban therapy after warfarin discontinuation were derived for Caucasian and Japanese patients using safety and efficacy criteria described previously, together with the coagulation model. The findings of our study provide a mechanistic pharmacologic rationale for dosing schedules during the therapy switch from warfarin to rivaroxaban and support the switching strategies as outlined in the Summary of Product Characteristics and Prescribing Information for rivaroxaban. PMID:25426077

  8. Low-temperature magnetic ordering in the perovskites Pr 1-xA xCoO 3 (A=Ca, Sr)

    Science.gov (United States)

    Deac, Iosif G.; Tetean, Romulus; Balasz, Istvan; Burzo, Emil

    2010-05-01

    The magnetic and electrical properties of polycrystalline Pr 1-xA xCoO 3 cobaltites with A=Ca, Sr and 0≤ x≤0.5 were studied in the temperature range 4 K≤ T≤1000 K and field up to 7 T. The X-ray analyses show the presence of only one phase having monoclinic or orthorhombic symmetry. The magnetic measurements indicate that the Ca-doped samples have at low temperatures, similar properties to the frustrated magnetic materials. PrCoO 3 is a paramagnetic insulator in the range from 4 to 1000 K. The Sr-doped cobaltites exhibit two phase transitions: a paramagnetic-ferromagnetic (or magnetic phase separated state) phase transition at about 240 K and a second one at about 100 K. The magnetic measurements suggest the presence of magnetic clusters and a change in the nature of magnetic coupling between Co ions at low temperatures. A semiconducting type behavior and high negative magnetoresistance was found for the Ca-doped samples, while the Sr-doped ones were metallic and with negligible magnetoresistance. The results are analyzed in the frame of a phase separation scenario in the presence of the spin-state transitions of Co ions.

  9. Los bienes de capital en el Programa de Cooperación e Integración Argentina-Brasil : 1986-1989

    OpenAIRE

    Luchetti, Javier Fernando

    2005-01-01

    El MERCOSUR es constituido como una continuidad del Programa de Integración y Cooperación entre Argentina y Brasil, si bien abandona sus principios fundamentales, cambiando sensiblemente su diseño global y el modelo de integración subyacente. El PICAB se proponía crear un espacio económico común para mejorar el bienestar de los pueblos, mediante una complementación de sectores de las economías de ambos países, según los principios de gradualismo, flexibilidad, selectividad, equilibrio, profun...

  10. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  11. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    OpenAIRE

    Virtudes Rodero Sánchez; Carme Vives Relats; Sagrario Acebedo Urdiales; Carme Ferré Grau

    2010-01-01

    El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1) Cronicidad y concepto de sentirse b...

  12. Ingresos y bienes en la vejez, un acercamiento a la configuración de la seguridad económica de los adultos mayores mexiquenses

    Directory of Open Access Journals (Sweden)

    Mariana MADRIGAL-MARTÍNEZ

    2010-01-01

    Full Text Available El propósito del artículo es establecer la conformación de la seguridad económica de la población adulta mayor mexiquense con base en las fuentes de ingreso y bienes a las que tiene acceso. Los resultados de la encuesta ESEDEM 2008 comprueban la hipótesis de que la seguridad económica está fuertemente relacionada con el perfil sociodemográfico del adulto mayor y muestra serias desventajas para los grupos que presentan características asociadas con mayores niveles de exclusión.

  13. Palpitando la modernidad: el negocio de bienes raíces en Cali (Colombia) a partir del caso de Jorge Garcés Borrero, 1900-1944

    OpenAIRE

    María Fernanda Erazo Obando

    2014-01-01

    El objetivo del presente artículo es analizar el movimiento de compra y venta de bienes raíces en Cali (Colombia) durante la primera mitad del siglo XX. Para ello, se toma como referencia la empresa del comerciante Jorge Garcés Borrero, la cual, se enfocó principalmente en la ejecución de este tipo de negocios. Dicha empresa, a pesar de no haberse constituido legal y jurídicamente, presentó las características de una compañía como tal, generando importantes inversiones y ganancias a partir de...

  14. Valoración de los bienes y servicios que presta la agricultura. Aplicación al sistema agrario de la huerta de valencia

    OpenAIRE

    Marqués Pérez, Inmaculada

    2013-01-01

    Con esta investigación hemos pretendido contribuir al reconocimiento de la multifuncionalidad de la agricultura, defendiendo una actividad que desempeña una función económica, a la vez que otras funciones relativas la protección del medio ambiente y del paisaje, a la conservación del patrimonio cultural, a la mejora de los aspectos de equilibrio social, así como la posibilidad de proveer servicios recreativos. Estas funciones generan bienes y servicios que no tienen mercad...

  15. El bien jurídico protegido por el delito de trata de personas en el ordenamiento jurídico peruano

    OpenAIRE

    Villarroel Quinde, Carlos Abel

    2017-01-01

    La presente investigación tiene por objeto analizar dogmáticamente el bien jurídico protegido por el delito de trata de personas en el ordenamiento jurídico peruano. Al respecto, existen diversas posturas sobre dicho tópico, lo que determina la poca o nula aplicación del tipo penal de acuerdo al bajo índice de sentencias expedidas por dicho delito en nuestro país. En ese sentido –a partir de un análisis exclusivamente teórico, basado en fuentes jurídicas (normas, jurisprudencia...

  16. Comentarios sobre el documento de la UNESCO “Replantear la educación. ¿Hacia un bien común mundial?”.

    OpenAIRE

    Pinto-Guerra, Gustavo

    2016-01-01

    La Unesco, a finales del 2015, en el documento “Replantear la educación ¿Hacia un bien común mundial?”, dimensiona las características para el funcionamiento y propósito del sistema educativo a nivel mundial, basadas en el fortalecimiento del respeto a las diversidades y las necesidades del contexto particular en el que se desarrollan los contenidos educativos. Esto solo es posible si se fortalecen valores cooperativos como, por ejemplo, la solidaridad, y se elimina la idea de la competencia,...

  17. La repercusión del valor razonable de los bienes inmuebles en la utilidad de los estados financieros: una nota de investigación

    Directory of Open Access Journals (Sweden)

    Andrés Navarro Galera

    2009-01-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.

  18. Retos para el desarrollo de una economía no convencional y perspectivas sobre la valoración de bienes ambientales

    Directory of Open Access Journals (Sweden)

    Alexander Martínez R.

    2010-12-01

    Full Text Available La teoría económica se ha dividido claramente en dos grandes narrativas: la economía convencional y la economía no convencional. La primera no solo se caracteriza por su arsenal matemático, sino también por su alta carga ideológica en la perspectiva del liberalismo económico. La segunda es una teoría en construcción, con sendos avances metodológicos y estudios de campo, pero aún se encuentra profundamente cuestionada por la epistemología positivista. Este ensayo pretende abreviar los temas más críticos de aquellas dos teorías económicas, con especial énfasis en los instrumentos analíticos de la economía convencional para valorar bienes ambientales (economía ambiental, y mostrar resumidamente los supuestos teóricos y fortalezas de la economía no convencional (bioeconomía en materia de valoración de bienes ambientales. Finalmente, se propone un modelo de interpretación del mercado que reestructura la noción de Valor Económico Total de la economía ambiental, en una perspectiva bioeconómica.

  19. Bienes y servicios ecosistémicos en la planificación y gestión de áreas urbanas consolidadas

    Directory of Open Access Journals (Sweden)

    Rafael Francesconi Latorre

    2014-06-01

    Full Text Available En el contexto de una planificación que declara privilegiar los elementos de la estructura ecológica, pero que podría comprometer la provisión de suelos para soportar coberturas que ofrezcan bienes y servicios ecosistémicos, se presenta un aporte a la discusión sobre cómo lograr un balance entre densificación y provisión de estos bienes y servicios, mediante la reconstrucción de la transformación de la cobertura de un segmento de la cuenca del río Fucha en Bogotá en un lapso de 77 años y la verificación de las relaciones de dicha transformación con los instrumentos de planificación y gestión. Los resultados obtenidos sugieren una regulación reactiva, con limitaciones para conducir la ocupación del territorio, de la que se puede esperar una acentuación de la aridez. Estos resultados sustentan las conclusiones sobre la necesidad de replantear la regulación sobre áreas consolidadas e introducir instrumentos de gestión de la cobertura.

  20. Personal, particular y político: la producción del bien público en la práctica política cotidiana

    Directory of Open Access Journals (Sweden)

    Victoria Ortiz de Rozas

    Full Text Available Resumo El objetivo del artículo es estudiar, a través de la actividad de quienes ocupan cargos políticos, las prácticas concretas que intervienen en la producción del “bien público”, entendido como la distribución de los bienes públicos hacia los ciudadanos. El interés surge de la tensión entre el comportamiento ideal de los políticos –según reglas universales y públicamente orientadas- y una práctica concreta que implica tener en cuenta problemáticas de ciudadanos y grupos sociales determinados, así como los propios intereses políticos. Se cuestiona la relación entre impersonalidad e interés público, planteando que la distribución personalizada de los bienes públicos no supone necesariamente su apropiación privada. Se presenta el estudio empírico de la actividad cotidiana de diferentes políticos con distintos cargos electivos, pertenecientes al partido gobernante, en la provincia de Santiago del Estero, cuyo régimen político ha sido caracterizado por la importancia de las relaciones personales y la politización de la burocracia. Siguiendo una estrategia metodológica cualitativa- que recurre a las técnicas de las entrevistas en profundidad y a la observación no participante; se reconstruye su actividad política cotidiana y las nociones de los políticos sobre sus propias prácticas; prestando atención a las formas de vinculación con los ciudadanos y con otros políticos y funcionarios. El artículo muestra que las tareas de los políticos provinciales, involucran el contacto personalizado tanto con los ciudadanos, como con funcionarios de distintos niveles de la administración pública, que les permiten viabilizar la distribución de bienes públicos hacia sus representados; actividades principalmente de carácter informal. Se muestra que, aunque los objetos de sus acciones sean ciudadanos y grupos territoriales determinados –lejos de la ciudadanía concebida en forma abstracta-, ello no es

  1. A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa.

    Science.gov (United States)

    Thakur, Rupamoni; Kumar, Ashok; Bose, Biplab; Panda, Dulal; Saikia, Debashree; Chattopadhyay, Pronobesh; Mukherjee, Ashis K

    2014-10-01

    Compounds showing dual inhibition of thrombin and factor Xa (FXa) are the subject of great interest owing to their broader specificity for effective anticoagulation therapy against cardiovascular disorders. This is the first report on the functional characterization and assessment of therapeutic potential of a 4423.6 Da inhibitory peptide (Ruviprase) purified from Daboia russelii russelii venom. The secondary structure of Ruviprase is composed of α-helices (61.9%) and random coils (38.1%). The partial N-terminal sequence (E(1)-V(2)-X(3)-W(4)-W(5)-W(6)-A(7)-Q(8)-L(9)-S(10)) of Ruviprase demonstrated significant similarity (80.0%) with an internal sequence of apoptosis-stimulating protein reported from the venom of Ophiophagus hannah and Python bivittatus; albeit Ruviprase did not show sequence similarity with existing thrombin/FXa inhibitors, suggesting its uniqueness. Ruviprase demonstrated a potent in vitro anticoagulant property and inhibited both thrombin and FXa following slow binding kinetics. Ruviprase inhibited thrombin by binding to its active site via an uncompetitive mechanism with a Ki value and dissociation constant (KD) of 0.42 μM and 0.46 μM, respectively. Conversely, Ruviprase demonstrated mixed inhibition (Ki = 0.16 μM) of FXa towards its physiological substrate prothrombin. Furthermore, the biological properties of Ruviprase could not be neutralized by commercial polyvalent or monovalent antivenom. Ruviprase at a dose of 2.0 mg/kg was non-toxic and showed potent in vivo anticoagulant activity after 6 h of intraperitoneal treatment in mice. Because of the potent anticoagulant property as well as non-toxic nature of Ruviprase, the possible application of the peptide as an antithrombotic agent for combating thrombosis-associated ailments appears promising. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  2. Effect of MCM09, an active site-directed inhibitor of factor Xa, on B16-BL6 melanoma lung colonies in mice.

    Science.gov (United States)

    Rossi, C; Hess, S; Eckl, R W; di Lena, A; Bruno, A; Thomas, O; Poggi, A

    2006-03-01

    Treatment with anticoagulant drugs has shown potential inhibitory effect on tumor invasion, although the relationship with clotting inhibition was not clear. The aim of our study was to evaluate the potential antitumor activity of MCM09, a newly developed, active site-directed, small molecule inhibitor of factor Xa (FXa) [WO0216312], and to relate the findings to anticlotting potency. MCM09 (0.1-10 mg kg(-1)) or heparin (H; 10 mg kg(-1)) was injected intravenously (i.v.), with 5 x 10(4) B16-BL6 melanoma cells, in C57BL/6 mice. Mice were killed after 18 days, to count lung colonies. Ex vivo anticoagulant activity was measured by activated partial thromboplastin time (APTT) on mouse plasma. MCM09, a selective inhibitor of FXa (IC-50 = 2.4 nm against human FXa), inhibited in a dose-dependent manner B16-BL6 melanoma lung colonies in mice. Mean lung metastasis number was 20.9 +/- 4.8 in controls (n = 10), 1.2 +/- 0.4 in mice treated with H, 10 mg kg(-1) i.v. (P < 0.01), 0.9 +/- 0.3, 9.2 +/- 2.2 and 15.5 +/- 2.6 in mice treated with MCM09, at 10 (P < 0.01), 1 (P < 0.05) and 0.1 mg kg(-1) i.v. (ns), respectively. MCM09 (10 mg kg(-1) i.v.) significantly prolonged APTT (57.1 +/- 10.2 s) 30 min after i.v. injection when compared with controls (25.3 +/- 1.6 s; P < 0.05). Lung colonies were 74.2-72.6% reduced by MCM09 (10 mg kg(-1)) given 60 or 120 min before cells, but not by MCM09 given 60 min thereafter, suggesting a direct cell interaction as a mechanism underlying antitumor activity.

  3. Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics

    Directory of Open Access Journals (Sweden)

    Gowda Veerabasappa T

    2007-12-01

    Full Text Available Abstract Background The snake venom group IIA secreted phospholipases A2 (SVPLA2, present in the Viperidae snake family exhibit a wide range of toxic and pharmacological effects. They exert their different functions by catalyzing the hydrolysis of phospholipids (PL at the membrane/water interface and by highly specific direct binding to: (i presynaptic membrane-bound or intracellular receptors; (ii natural PLA2-inhibitors from snake serum; and (iii coagulation factors present in human blood. Results Using surface plasmon resonance (SPR protein-protein interaction measurements and an in vitro biological test of inhibition of prothrombinase activity, we identify a number of Viperidae venom SVPLA2s that inhibit blood coagulation through direct binding to human blood coagulation factor Xa (FXa via a non-catalytic, PL-independent mechanism. We classify the SVPLA2s in four groups, depending on the strength of their binding. Molecular electrostatic potentials calculated at the surface of 3D homology-modeling models show a correlation with inhibition of prothrombinase activity. In addition, molecular docking simulations between SVPLA2 and FXa guided by the experimental data identify the potential FXa binding site on the SVPLA2s. This site is composed of the following regions: helices A and B, the Ca2+ loop, the helix C-β-wing loop, and the C-terminal fragment. Some of the SVPLA2 binding site residues belong also to the interfacial binding site (IBS. The interface in FXa involves both, the light and heavy chains. Conclusion We have experimentally identified several strong FXa-binding SVPLA2s that disrupt the function of the coagulation cascade by interacting with FXa by the non-catalytic PL-independent mechanism. By theoretical methods we mapped the interaction sites on both, the SVPLA2s and FXa. Our findings may lead to the design of novel, non-competitive FXa inhibitors.

  4. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial.

    Science.gov (United States)

    Barco, Stefano; Lankeit, Mareike; Binder, Harald; Schellong, Sebastian; Christ, Michael; Beyer-Westendorf, Jan; Duerschmied, Daniel; Bauersachs, Rupert; Empen, Klaus; Held, Matthias; Schwaiblmair, Martin; Fonseca, Cândida; Jiménez, David; Becattini, Cecilia; Quitzau, Kurt; Konstantinides, Stavros

    2016-07-04

    Pulmonary embolism (PE) is a potentially life-threatening acute cardiovascular syndrome. However, more than 95 % of patients are haemodynamically stable at presentation, and among them are patients at truly low risk who may qualify for immediate or early discharge. The Home Treatment of Pulmonary Embolism (HoT-PE) study is a prospective international multicentre single-arm phase 4 management (cohort) trial aiming to determine whether home treatment of acute low-risk PE with the oral factor Xa inhibitor rivaroxaban is feasible, effective, and safe. Patients with confirmed PE, who have no right ventricular dysfunction or free floating thrombi in the right atrium or ventricle, are eligible if they meet none of the exclusion criteria indicating haemodynamic instability, serious comorbidity or any condition mandating hospitalisation, or a familial/social environment unable to support home treatment. The first dose of rivaroxaban is given in hospital, and patients are discharged within 48 hours of presentation. Rivaroxaban is taken for at least three months. The primary outcome is symptomatic recurrent venous thromboembolism or PE-related death within three months of enrolment. Secondary outcomes include quality of life and patient satisfaction, and health care resource utilisation compared to existing data on standard-duration hospital treatment. HoT-PE is planned to analyse 1,050 enrolled patients, providing 80 % power to reject the null hypothesis that the recurrence rate of venous thromboembolism is >3 % with α≤0.05. If the hypothesis of HoT-PE is confirmed, early discharge and out-of-hospital treatment may become an attractive, potentially cost-saving option for a significant proportion of patients with acute PE.

  5. ¿Serían la Guardia, Tutela y Curatela Bienes Jurídicos Penales? Un Análisis Crítico de los Arts. 248 y 249 del CP a la Luz de la Exclusiva Protección de Bienes Jurídicos

    Directory of Open Access Journals (Sweden)

    Gerson Faustino Rosa

    2015-12-01

    Full Text Available El presente trabajo tiene por objeto el análisis crítico y la explotación de un importante problema político-criminal de la actualidad: la criminalización de conductas que afrontan la guarda, la tutela y la curatela en el Código Penal, en sus artículos 248 y 249, lo que ya no tiene sentido ante la actual función del sistema penal, criticándose la actividad desenfrenada del Poder Legislativo, que produce ley espenales que no protegen bien jurídico alguno,oque salvaguardan bienes pasibles de protección por otras esferas del Derecho, valiéndose de la fuerza simbólico-comunicativa del Derecho Penal de forma desnecesaria, ampliando demasiadamente el alcance de la pena criminal, hasta el punto de vulgarizar todo el sistema jurídico penalenrazón de su uso indiscriminado. Paraello, enprimer plano,este estudio trata de la política criminal relativa a la libre planificación familiar, criticando la intervención estatal en cuestiones familiares, como ocurre en el Código Penal de 1940, destacando la necesidad de respetarse los principios de intervención mínima y de proporcionalidad antes de que el legislador se valga de la injerencia penal para la protección de cualquier bien jurídico. Más adelante, se presenta la importancia del bien jurídico-penal, con énfasis en la familia como bien jurídico categorial, especialmente la guardia, tutela y curatela, supuestamente lesionadas por los delitos de los artículos 248 y 249 del Código Penal. Así, se analizan brevemente los tipos penales citados, criticándose dicha criminalización, teniéndose en cuenta que tales tipos son subsidiarios, perfectamente prescindibles en el ordenamiento jurídico-penal y pasibles de salvaguardia por el Derecho Civil, que en la solución de los conflictos familiares se muestra mucho más eficaz que la intervención penal.

  6. Producción y percepción de bienes públicos en la lógica de la acción colectiva

    Directory of Open Access Journals (Sweden)

    Jordana, Jacint

    2007-04-01

    Full Text Available Public goods having different proprieties produce different problems of collective action. This hypothesis has been discussed from different analytical perspectives and we examine their arguments, aiming to deepen our theoretical understanding about the logic of collective action. In this paper we look for similarities and differences regarding their use of concepts and expected results. Simultaneously, we examine the link between different public goods and the interdependent behavior of individuals. To this purpose, we also revisit the connections between production functions and consumption types in the case of public goods, as a mean to explore the potential development of more elaborated models in the theory of collective action, and suggest that more empirical contrast of these models is needed. Finally, we argue the importance for theoretical discussions to include a discussion about the impact of perception in the collective action models, considering systematic deviations to rational choice, and conclude that no single theory may address all collective action problems, but systematic patterns of behavior may be identified and empirically confirmed.

    Bienes públicos con distintas propiedades generan problemas diferentes de acción colectiva. Esta hipótesis ha sido discutida, desde distintas perspectivas analíticas, con el objeto de profundizar teóricamente sobre la lógica de la acción colectiva. En este trabajo se revisan las aportaciones recientes a esta cuestión, analizando sus puntos de encuentro y sus divergencias en cuanto a conceptos y resultados esperados. Asimismo, se examina la relación entre tipos distintos de bienes públicos y el comportamiento interdependiente de los individuos. Con este fin, los vínculos entre las funciones de producción y las formas de consumo de bienes públicos también son considerados, ya que permite desarrollar modelos más ambiciosos sobre la lógica de la acción colectiva. Finalmente

  7. La opacidad de los acuerdos generales de bienes y servicios en España Opacity of general agreements on goods and services in Spain

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    Román Andrés Umaña Peña

    2006-06-01

    Full Text Available Objetivo: Explorar la intensidad del debate parlamentario sobre el Acuerdo General de Comercio de Servicios (AGCS asumido por España ante la Organización Mundial del Comercio (OMC, y compararla con la del Acuerdo General de Bienes (GATT. Métodos: Búsqueda sistemática y análisis del contenido de todas las iniciativas parlamentarias sobre AGCS y GATT realizadas entre 1979 y 2004 en el Congreso de los Diputados y el Senado. Se calculó la frecuencia y porcentaje de iniciativas parlamentarias de ambos temas, resultado de su tramitación y tipo de iniciativa. Resultados: Se presentaron 185 iniciativas parlamentarias sobre los acuerdos multilaterales de bienes y servicios, de las que 120 se referían al GATT, 8 al AGCS y 57 a ambos acuerdos. La mayoría de las iniciativas no fueron discutidas (GATT, 71%; GATS, 55,4% o estuvieron sujetas a un debate político en el que apenas se dieron intervenciones por parte de los grupos parlamentarios. Conclusiones: A pesar de las implicaciones del acuerdo multilateral de servicios para la política sanitaria española, éste se ha asumido con escaso debate parlamentario previo, incluso menos que en el caso de su homólogo sobre bienes. Se requiere en este tema una intensificación de la función de control al gobierno.Objective: To explore the intensity of the debate in the Spanish Parliament on the General Agreement on Trade in Services (GATS developed by Spain and the World Trade Organization, and to compare it with the debate on the General Agreement on Tariffs and Trade (GATT. Methods: A systematic search and content analysis were performed of all parliamentary initiatives on GATS and GATT undertaken from 1979 to 2004 in the Spanish Parliament and Senate. The frequency and percentages of initiatives on both issues were calculated, and the final result and kinds of initiative were analyzed. Results: A total of 185 initiatives were presented in the Spanish Parliament on these agreements, of which 120 were

  8. Discriminación de género en el acceso a bienes y servicios en el tráfico mercantil entre privados

    Directory of Open Access Journals (Sweden)

    María Angustias Díaz Gómez

    2015-06-01

    Full Text Available La Directiva 2004/113/CE, y la Ley Orgánica 3/2007 que la traspone representan un avance en el Derecho antidiscriminatorio por razón de género y en concreto al suministro de bienes y servicios. En este trabajo nos centramos en el acceso a los ofertados desde el sector privado de la economía. Apuntamos a la deficiente incorporación en España de algunas disposiciones de la Directiva; a la necesidad de superar el recurso a la nulidad como principal solución de controversias; así como a la conveniencia de que la regulación antidiscriminatoria de derecho privado reciba un tratamiento legislativo transversal, para así hacer eficaz el derecho a la igualdad y el propio derecho del mercado en áreas tan relevantes como la competencia desleal.

  9. Perspectivas del crecimiento urbano: la actividad comercial minorista y el transporte de bienes en la Zona Metropolitana de Querétaro (México

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    Eduardo Betanzo-Quezada

    2015-01-01

    Full Text Available Se muestran las perspectivas del crecimiento urbano, la actividad comercial minorista y su relación transversal con el transporte de bienes en la Zona Metropolitana de Querétaro (México. Con una metodología de análisis de información estadística de tipo agregado, se examinan esos determinantes con el objetivo de revelar sus tendencias en la ciudad. El paralelismo encontrado en las tendencias de comportamiento de los determinantes examinados conduce a concluir que es cada vez más necesario conectar al transporte urbano de carga con la planeación económica y urbana, y ubicarlo dentro de las prioridades de las administraciones gubernamentales.

  10. Delito de Bigamia e Intervención Mínima: ¿Es el Matrimonio, Todavía, un Bien Jurídico-Penal?

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    Gerson Faustino Rosa

    2016-10-01

    Full Text Available Este artículo trata de los delitos contra el matrimonio, y del delito de bigamia como figura central, que no es compatible con la función actual del sistema penal, criticándose los bienes que deberían ser objeto de protección por otras áreas del derecho. Se trata de la política criminal sobre la planificación familiar, criticándose la intervención del Estado en los asuntos familiares. Se destacan los principios de intervención mínima, fragmentaridad, subsidiariedad y proporcionalidade. Se analiza el tipo penal del art. 235 del Código Penal, criticándose dicha penalización, dado que es un tipo penal subsidiario, perfectamente prescindible por el ordenamiento jurídico-penal.

  11. Valoración económica de bienes públicos: estudio de caso del río Lerma, La Piedad, Michoacán

    OpenAIRE

    Gómez Sántiz, Faustino; Guerrero García Rojas, Hilda R.

    2015-01-01

    El tramo del río Lerma, que atraviesa la zona metropolitana de La Piedad de Cabadas, Michoacán-Santa Ana Pacueco, Guanajuato, tiene una longitud de 12.8 km. Actualmente está convertido en un canal de desechos, que ha incidido en la aparición de fuertes problemas de salud pública. En este estudio se utilizó el método de valoración contingente y el modelo logit para determinar el valor económico total de este bien ambiental, y para analizar las variables de la decisión sobre la disposición a pa...

  12. Ambivalencias de la migración y el retorno en contextos rurales de Chiapas: Entre las multas y el bien común

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    Germán MARTÍNEZ VELASCO

    2017-01-01

    Full Text Available Convertirse en migrante internacional en el ámbito de una comunidad indígena chiapaneca entra en tensión con los sistemas normativos que en nombre del bien común reclaman participación de sus miembros. Rehusar a cubrir tareas civiles será aceptado mediante el pago de una multa por el candidato a emigrar. De ahí la existencia de esta instancia comunitaria en la regulación de la migración. El retorno pasa por la calificación comunitaria, además de que las iniciativas de los retornados se ven limitadas. Todo lo anterior ocurre en comunidades, en donde la membresía a una comunidad entraña un lazo de identificación cultural.

  13. Monitoring low molecular weight heparins at therapeutic levels: dose-responses of, and correlations and differences between aPTT, anti-factor Xa and thrombin generation assays.

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    Owain Thomas

    Full Text Available Low molecular weight heparins (LMWH's are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa, activated partial thromboplastin time (aPTT and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.To examine the effects of two different LMWH's on the results of 4 different aPTT-tests, anti-FXa activity and thrombin generation and to assess the tests' concordance.Enoxaparin and tinzaparin were added ex-vivo in concentrations of 0.0, 0.5, 1.0 and 1.5 anti-FXa international units (IU/mL, to blood from 10 volunteers. aPTT was measured using two whole blood methods (Free oscillation rheometry (FOR and Hemochron Jr (HCJ and an optical plasma method using two different reagents (ActinFSL and PTT-Automat. Anti-FXa activity was quantified using a chromogenic assay. Thrombin generation (Endogenous Thrombin Potential, ETP was measured on a Ceveron Alpha instrument using the TGA RB and more tissue-factor rich TGA RC reagents.Methods' mean aPTT at 1.0 IU/mL LMWH varied between 54s (SD 11 and 69s (SD 14 for enoxaparin and between 101s (SD 21 and 140s (SD 28 for tinzaparin. ActinFSL gave significantly shorter aPTT results. aPTT and anti-FXa generally correlated well. ETP as measured with the TGA RC reagent but not the TGA RB reagent showed an inverse exponential relationship to the concentration of LMWH. The HCJ-aPTT results had the weakest correlation to anti-FXa and thrombin generation (Rs0.62-0.87, whereas the other aPTT methods had similar correlation coefficients (Rs0.80-0.92.aPTT displays a linear dose-response to LMWH. There is variation between aPTT assays. Tinzaparin increases aPTT and decreases thrombin generation more than enoxaparin at any given level of anti-FXa activity, casting doubt on anti-FXa's present gold standard status. Thrombin generation with tissue factor-rich activator is a promising method for monitoring LMWH's.

  14. La Repercusión del Valor Razonable de los Bienes Inmuebles en la Utilidad de los Estados Financieros: Una Nota de Investigación

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    Andrés Navarro Galera

    2009-06-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.The option in the recent Spanish regulation for fair value over historical cost, as the preferred measurement basis for some assets, has raised some controversy. This paper studies the effects on accounting information relevance and reliability of fair value accounting for investment properties. The empirical study is based on a questionnairebased survey of the perceptions of 151 Spanish accountants in the building industry about the usefulness and reliability of fair value accounting. The analysis of results allows us concluding that accountants perceive that the usefulness of financial statements increases when investment property is valued on a fair value basis, compared with a historical cost basis. However, respondents

  15. Acuerdos de pesca en los lagos de Tarapoto: Alternativa de gestión para los bienes comunes en la Amazonia colombiana

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    Catalina Trujillo Osorio

    2017-09-01

    Full Text Available Se presentan las experiencias de gestión de recursos pesqueros en resguardos indígenas del Amazonas colombiano y los resultados y limitaciones del proceso adelantado para la construcción de acuerdos comunitarios de pesca. Se usó la metodología de investigación-acción-participación respondiendo al objetivo de crear estrategias para contrarrestar los problemas de agotamiento del recurso pesquero de los lagos de Tarapoto en el resguardo Ticoya y consolidar estrategias propias para fortalecer la capacidad de gobernanza interna del recurso pesquero dentro del territorio indígena. Se encontró que los acuerdos de pesca actúan como instituciones que regulan y optimizan el uso de bienes comunes de libre acceso, y consolidan la capacidad de gobernanza en territorios indígenas. Se concluye que la consolidación de un sistema propio de gestión debe ir más allá del control del recurso, evidenciando los esfuerzos locales por adoptar sistemas de manejo alternativo que se integren al modo de vida indígena y a los modelos de producción tradicional.

  16. Validación del Índice de Bien-estar Personal en personas con enfermedad renal crónica

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    Luís Manuel Mota de Sousa

    Full Text Available Objetivo: verificar las propiedades psicométricas del Índice de bien-estar personal (IBP en personas con enfermedad renal crónica en programa de hemodiálisis. Método: Se trata de un estudio metodológico. La muestra aleatoria es constituida por 171 personas con Enfermedad Renal Crónica (ERC sometida a hemodiálisis en dos clínicas en la región de Lisboa, Portugal. La recogida de datos fue realizada entre mayo y junio de 2015. Se evaluaron las propiedades psicométricas: validad (constructo, predictiva convergente, y discriminativa, confiabilidad por medio de la consistencia interna (α de Cronbach y estabilidad (Coeficiente de Correlación de Spearman-Brown y Coeficiente de Correlación Intraclasse (CCI. Resultados: El IBP presenta una dimensión ajustada a los datos. La satisfacción con la salud es lo que más contribuye para el IBP. Tiene validad convergente con Felicidad Subjetiva y Afecto Positivo y Afecto Negativo. Tiene poder discriminativo en la nacionalidad. El a Cronbach fue de 0,82. Teste Re-teste para cuestionario 0, 92 e CCI= 0,95, para entrevista 0,85 y CCI= 0,89. Conclusiones: La versión portuguesa del IBP es válida y reproducible en personas con ERC, tanto por cuestionario como por entrevista.

  17. Aspectos generales del régimen de los bienes del litoral marítimo. Competencias y limitaciones sobre el Derecho de propiedad

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    Sebastián Barreto Cifuentes

    2013-07-01

    Full Text Available El concepto de “propiedad”, tradicionalmente estudiado con la lógica del Derecho privado, ha sufrido cambios internos (la función social como núcleo esencial y externos (las limitaciones administrativas que hacen necesario estudiarlo con herramientas lógicas y metodológicas del Derecho público. Se debe considerar que un derecho absoluto e ilimitado no requiere mayor atención por parte de la disciplina del Derecho público. La armonización y articulación de los derechos del propietario con las competencias asignadas a las autoridades administrativas, exige una particular atención para proteger los derechos ciudadanos. En desarrollo de lo mencionado, se ha realizado un corto estudio sobre los bienes del litoral marítimo, en particular de las competencias asignadas a las autoridades administrativas sobre estas áreas, así como el límite de estas competencias. También se presentará el análisis de algunos casos reales y potenciales en los cuales se hace necesaria la aplicación de garantías procesales y sustanciales para el respeto de los derechos de los propietarios.

  18. Valoración económica de bienes públicos: estudio de caso del río Lerma, La Piedad, Michoacán

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    Faustino Gómez Sántiz

    2015-01-01

    Full Text Available el tramo del río Lerma, que atraviesa la zona metropoli-tana de La Piedad de Cabadas, Michoacán-Santa Ana Pacue-co, Guanajuato, tiene una longitud de 12.8 km. Actualmenteestá convertido en un canal de desechos, que ha incididoen la aparición de fuertes problemas de salud pública. Eneste estudio se utilizó el método de valoración contingentey el modelo logit para determinar el valor económico totalde este bien ambiental, y para analizar las variables de ladecisión sobre la disposición a pagar una contribución pararealizar mejoras, por parte de los beneficiarios de él. Dichovalor se estimó en más de 4 millones de pesos anuales, estoindica que de realizarse mejoras ambientales, la poblaciónse beneficiaría en la medida en que se lograra mitigar losefectos de la contaminación.

  19. Los bienes de interés cultural de Gáldar (Canarias y el conjunto histórico “Plaza de Santiago” (1981-2006

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    Juan Sebastián López García

    2013-10-01

    Full Text Available En 1981, hace veinticinco años, la zona central de Gáldar fue declarada “Conjunto Histórico Artístico” con la denominación de Plaza de Santiago. Sin embargo no era el primer bien cultural que obtenía una distinción de este tipo, ya que Gáldar había sido pionera en 1949 con el yacimiento de El Agujero y La Guancha, primero de los de carácter arqueológico declarado en Canarias, al que seguiría en 1972 la Cueva Pintada. Hasta la década de los setenta prevalecieron los bienes arqueológicos, situación que se modificó en las dos últimas décadas del siglo XX después del reconocimiento de la Plaza de Santiago y su entorno. Junto con edificaciones religiosas también se incluyeron ejemplos de arquitectura doméstica, completándose con algunos yacimientos prehispánicos. Una particular circunstancia fue la declaración en 1993 del pago de Barranco Hondo de Abajo, lo que convertía a Gáldar en el primer municipio de Canarias que contaba con dos conjuntos históricos, siendo éste a la vez el primero de la comunidad autonóma con características rurales. De la relación de los declarados, si exceptuamos la mayoría de los de carácter arqueológico, buena parte son urbanos. Una característica es que se incluyen categorías variadas, incluyendo la existencia de una zona arqueológica junto a un conjunto histórico y varios monumentos (de arquitectura religiosa y doméstica. Este hecho es lógico si se tiene en cuenta la particularidad de Gáldar y su condición de núcleo histórico de superposición.Twenty five years ago, in 1981, the central zone of Galdar was declared an "Historic Artistic Site" with the name of Plaza de Santiago. But this was not the first cultural asset to obtain a distinction of this kind, as Galdar pioneered protection of this kind with the El Agujero and La Guancha site, the first archaeological site declared in the Canary Islands, followed by La Cueva Pintada, in 1972. Archaeological assets prevailed up

  20. Composición de los hogares y niveles de gastos en bienes y servicios básicos en el departamento del cauca, Colombia

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    Andrés Mauricio Gómez Sánchez

    2016-03-01

    Full Text Available Éste documento tiene como objetivo caracterizar los hogares rurales y urbanos del departamento del Cauca, Colombia y clasificarlos según la tipología y el ciclo de vida del hogar, para establecer su relación con los niveles de gasto mínimo en bienes básicos, es decir, con los que definen los umbrales críticos de pobreza. Para tal efecto, se utiliza la Encuesta de Calidad de Vida de 2011 y se estiman modelos de análisis de varianza multifactoriales. Los resultados muestran, entre otros, que el tipo de hogar más frecuente, tanto en el área rural como la urbana, es el nuclear con hijos y los gastos mínimos básicos, en general, son en alimentos, vivienda y salud. Los rubros de educación y transporte presentan niveles más altos de consumo en los hogares urbanos que en los rurales. The main objective of this paper is to describe the rural and urban households of the Cauca department in Colombia. The idea is to classify the households according to their typology and household life cycle in order to establish their relation with the minimum levels of expenditure on basic goods, this means with the ones that define the critical poverty thresholds. For this end, the 2011 Quality of Life survey is used as well as multifactorial variance analysis. The results show that the most common type of household for both rural and urban areas is the nuclear type of household with children, showing usually a minimal basic expenditure on food, housing and health. Education and transportation present higher consump-tion levels at urban households.

  1. Honor femenino y economía de bienes simbólicos en Maracaibo, Venezuela, a finales del siglo XIX (1880 – 1900

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    Luis Rincón Rubio

    2008-05-01

    Full Text Available Se presenta en este trabajo una aproximación antropológica a las representaciones culturales del honor femenino circulantes en la ciudad de Maracaibo, Venezuela, a finales del siglo XIX. La investigación realizada adopta un enfoque teórico-metodológico de corte estructuralista-constructivista, abordando el orden social como un sistema simbólico organizado según una lógica de la diferencia y partiendo de la premisa de que prácticas y representaciones están orientadas externamente por las estructuras objetivas de la sociedad, e internamente por esquemas de percepción, pensamiento y acción de origen social. Al tratarse de un trabajo de antropología histórica, los informantes fueron sustituidos por fuentes documentales ubicadas en diferentes archivos venezolanos. Se encuentra que las representaciones culturales del honor femenino en la sociedad en cuestión asociaban este concepto con la castidad sexual, reproduciendo esquemas culturales vigentes en la órbita del mundo occidental y proporcionando una lógica para el mantenimiento de relaciones desiguales de género y poder en la vida pública y privada de los marabinos. El capital social y el capital simbólico habrían sido componentes fundamentales del capital total de que se disponía entonces en la lucha cotidiana por la obtención de recursos y por el reconocimiento social, en una economía de bienes simbólicos que atribuía al parecer preferentemente a los hombres el trabajo oficial de conservación o incremento de dichas formas de capital.

  2. La evolución de las exportaciones de bienes de China: una visión panarómica = Chinese goods exports development: An overview

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    Ana Salvador Chamorro

    2013-12-01

    Full Text Available El proceso de reforma económica que ha experimentado la economía de China es uno de los fenómenos de mayor relevancia en la evolución de la Economía Mundial en los últimos treinta años y, sin duda, seguirá siéndolo en el futuro. Dentro de este proceso, la apertura al exterior, que el gobierno chino inició en 1978, ha situado al país en un lugar de máxima relevancia dentro de los flujos comerciales y financieros internacionales. En este contexto, el objetivo de este trabajo es intentar realizar un análisis general de la evolución del comercio exterior de China en las últimas décadas, prestando especial atención a sus exportaciones de bienes y poniendo énfasis en los cambios experimentados durante los últimos años.The process of economic reform that has experienced the Chinese economy is one of the most important events in the evolution of the World Economy in the past 30 years, and will undoubtedly remain so in the future. Within this economic reform, the opening process that the Chinese Government began in 1978, has put the country in a place of utmost importance in the international trade and financial flows. In this context, this paper try to perform an analysis of the evolution of China's foreign trade in recent decades, with particular attention to its exports and emphasizing the changes in recent years

  3. La evolución de las exportaciones de bienes de China: una visión panarómica = Chinese goods exports development: An overview

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    Ana Salvador Chamorro

    2014-07-01

    Full Text Available Resumen El proceso de reforma económica que ha experimentado la economía de China es uno de los fenómenos de mayor relevancia en la evolución de la Economía Mundial en los últimos treinta años y, sin duda, seguirá siéndolo en el futuro. Dentro de este proceso, la apertura al exterior, que el gobierno chino inició en 1978, ha situado al país en un lugar de máxima relevancia dentro de los flujos comerciales y financieros internacionales. En este contexto, el objetivo de este trabajo es intentar realizar un análisis general de la evolución del comercio exterior de China en las últimas décadas, prestando especial atención a sus exportaciones de bienes y poniendo énfasis en los cambios experimentados durante los últimos años. Abstract The process of economic reform that has experienced the Chinese economy is one of the most important events in the evolution of the World Economy in the past 30 years, and will undoubtedly remain so in the future. Within this economic reform, the opening process that the Chinese Government began in 1978, has put the country in a place of utmost importance in the international trade and financial flows. In this context, this paper try to perform an analysis of the evolution of China's foreign trade in recent decades, with particular attention to its exports and emphasizing the changes in recent years.

  4. The Role of RaxST, a Prokaryotic Sulfotransferase, and RaxABC, a Putative Type I Secretion System, in Activation of the Rice XA21-Mediated Immune Response

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    Pamela C. Ronald

    2014-01-01

    Full Text Available Tyrosine sulfation is an important posttranslational modification that determines the outcome of serious diseases in plants and animals. We have recently demonstrated that the plant pathogen Xanthomonas oryzae pv. oryzae (Xoo carries a functional sulfotransferase (RaxST. raxST is required for activation of rice Xa21-mediated immunity indicating the critical, but unknown, function of raxST in mediating the Xoo/rice interaction. The raxST gene resides in the same operon (raxSTAB as components of a predicted type I secretion and processing system (RaxA and RaxB. These observations suggest a model where RaxST sulfates a molecule that contains a leader peptide, which is cleaved by the peptidase domain of the RaxB protein and secreted outside the bacterial cell by the RaxABC T1SS.

  5. L’apprentissage du bien-être animal chez de futures professionnels animaliers : des éthiques animals malmenées

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    Vidal Michel

    2015-01-01

    Full Text Available Les débats dont le bien-être animal est l’objet entre chercheurs, professionnels et associations en font une question socialement vive scientifico-éthique. Ils en interrogent l’éducabilité alors que cette notion est prise en compte dans les curricula de l’enseignement agricole. Envisageant son enseignement au travers d’une éducation à l’empathie interspécifique, nous questionnons les facteurs susceptibles de l’influencer. Nous nous fondons sur le discours de sept élèves en baccalauréat professionnel relevant de l’élevage d’animaux de production ou d’animaux de compagnie durant deux années de formation. Six élèves, quelle que soit leur filière de formation, souhaitent créer une relation affective sans nécessairement développer une attitude empathique durant la formation. Parmi les facteurs responsables, nous distinguons (1 un manque de confiance en soi de l’élève, (2 des motivations égocentrées primant sur des motivations zoocentrées, (3 la loyauté et les habitudes acquises à l’égard des pratiques parentales, (4 la conformation aux pratiques et idéologies dominantes du monde professionnel, (5 des facteurs associés aux situations d’enseignement (savoirs et pratiques de référence qui font autorité, valeurs de conformité primant sur des valeurs éthiques, dissociation de la dimension relationnelle et productive de l’élevage, jugements négatifs portés par l’enseignant et les élèves originaires du monde agricole. Ces facteurs généreraient des mécanismes de défense chez l’élève nuisibles au développement d’un raisonnement affectivo-éthique critique.

  6. Gestión del territorio y manejo de bienes comunes en contextos extractivos: una aproximación al caso de las comunidades Kichwas del cantón Arajuno en la provincia de Pastaza, Ecuador.

    OpenAIRE

    Barrera Arroba, Danny Rafael

    2014-01-01

    La presente tesis analiza las diferentes transformaciones en el manejo del territorio y los bienes comunes, que se han generado en las comunidades kichwas de Elena y Huito ubicadas en el cantón Arajuno en la provincia de Pastaza en la Amazonía ecuatoriana, a partir de las actividades de explotación petrolera desarrolladas por la compañía AGIP Ecuador S.A. en el bloque 10 dentro del sector de Villano.

  7. Comparative physical mapping of rice BAC clones linked to resistance genes Glh,Bph-3 and xa-5 in Oryza sativa L.and O.granulata Nees et Am.ex Watt.

    Institute of Scientific and Technical Information of China (English)

    XIONG Zhiyong; TAN Guangxuan; YOU Aiqing; HE Guangyuan; SHE Chaowen; LI Lijia; SONG Yunchun

    2004-01-01

    Oryza granulata Nees et Arn. ex Watt. is one of the three wild relatives of rice, which are the most valuable for study and utilization in China. In this study, the homology and physical locations of three rice resistance genes, Glh,Bph-3 and xa-5 are comparatively analyzed between O. sativa and O. granulata by Southern blotting and fluorescence in situ hybridization (FISH). The results of Southern blotting indicate that there exist homologous sequences of the tested RFLP markers in O. granulata. By using three bacterial artificial chromosome (BAC) clones scanned by the tested RFLP as probes, FISH signals are detected on both mitotic and pachytene chromosomes in O. sativa and O. granulata.Dual-color FISH demonstrates that two of the three BAC clones (14E16 and 38J9) are located on the short arm of the same chromosome pair in O. granulata. Additionally, colinearity is shown for the two clones between O. sativa and O.granulata. Another BAC clone 44B4 is located on the end of the short arm of other chromosome pair in these two species.Although the phylogenetic relationship between O. sativa and O. granulata is the most distinct in Oryza and these two species have evidently different biological features and ecological habits, the relative lengths and arm ratios of the detected chromosomes and the relative positions of the tested clone signals on chromosomes in O. granulata are quite similar to those in O. sativa.

  8. Estudio del Uso de la Tarjeta Inteligente Adaptado a un Teléfono Móvil como Sistema para Adquirir Bienes y Servicios en la Ciudad de Guayaquil

    OpenAIRE

    Espín Martínez, Jorge Alfredo; Pilco Totoy, Mario Patricio

    2012-01-01

    Con el fin de seguir desarrollando el segmento de la tecnología y comunicaciones con nuevas aplicaciones, el presente estudio se enfoca en proponer al mercado una tarjeta inteligente adaptado en un celular; el mismo que servirá para transacciones de compra de bienes y servicios en establecimientos afiliados con la tecnología NFC; esta alternativa permitirá a los usuarios poder realizar con mayor seguridad sus compras ya que tendrán que utilizar el sistema de huella digital, y el mismo equipo ...

  9. Suma Qamaña, vivir bien, el Ethos de la nueva constitución boliviana (Suma Qamaña, Living Well, the Ethos of the new Bolivian constitution)

    OpenAIRE

    Fernández, Hugo

    2009-01-01

    Resumen: Este artículo expone algunos antecedentes que explican por qué se ha introducido la expresión Vivir Bien (Suma Qamaña y sus variantes) en el texto constitucional recientemente aprobado en Bolivia. Entre ellos menciona los sorprendentes resultados electorales obtenidos por Evo Morales, que se sustentan en la emergencia y consolidación del pensamiento indígena, en la clara voluntad de adquirir poder político por parte de las organizaciones indígenas y en la necesidad de cambiar el orde...

  10. El control de inventario físico de bienes muebles y su incidencia en la conciliación patrimonial con los estados financieros en la Universidad Nacional Santiago Antúnez de Mayolo, periodo 2015.

    OpenAIRE

    Minaya Santos, Armando Félix

    2017-01-01

    El propósito de la presente investigación fue determinar la incidencia del control de inventario físico de bienes muebles en la conciliación patrimonial con los estados financieros en la Universidad Nacional Santiago Antúnez de Mayolo 2015. Investigación de tipo aplicado, diseño no experimental, transversal. La población de estudio estuvo conformada por servidores administrativos profesionales y técnicos que laboran en los sistemas presupuesto, abastecimiento, contabilidad y...

  11. Riesgos en el proceso de importación ordinaria: identificación del mapa de riesgos de la importación de bienes de capital en Colombia

    OpenAIRE

    Gallón Perdomo, Sara María; Torres Muskus, Carlos Henrique

    2014-01-01

    En Colombia, durante el proceso de importación se presentan diversos riesgos, que pueden implicar desde sobrecostos hasta la pérdida de la mercancía -- Considerando que las importaciones son necesarias en las empresas, en la presente investigación se elabora un mapa de riesgos del proceso de importación ordinaria de bienes de capital en el país, con el fin de identificarlos, de tal manera que los importadores estén informados y puedan aplicar los métodos de control pertinentes para la adm...

  12. El tratamiento de los bienes y servicios que aporta la biodiversidad en manuales de la educación secundaria española: un estudio epistemológico

    Directory of Open Access Journals (Sweden)

    Gonzalo Miguel Angel Bermúdez

    2016-01-01

    Full Text Available Este trabajo estudia el tratamiento del concepto de servicios ecosistémicos en libros de texto de la educación secundaria obligatoria (ESO y bachillerato de España. Con el objetivo de definir su marco conceptual se recopilaron publicaciones científicas de la “comunidad de expertos”, que actúa de referente epistemológico en el proceso de transposición didáctica. El concepto de servicios ecosistémicos estuvo presente sólo en el 10 % de los manuales analizados (de un total de 50; sin embargo, en la mayoría de ellos se mencionó algún bien o servicio (sobre todo en libros de ciencias de la tierra y medioambientales. Estos resultados se relacionan con la ausencia de la conceptualización en el currículo español. Los servicios “directos” de los ecosistemas fueron tratados con mayor frecuencia que los “indirectos”. Aun así, se encontró un centrismo en las selvas tropicales como las únicas proveedoras de bienes, y escasa representación de los servicios sociales y culturales de la biodiversidad.

  13. En quoi la narration dans le romanL’Élégance du hérisson permet de bien rendre lamétaphore du « bocal à poissons »? : Une analyse narratologique

    OpenAIRE

    Racine, Sylvain

    2015-01-01

    Sur la base des travaux de Gérard Genette, en particulier Figures III, uneanalyse narratologique du roman L’Élégance du hérisson (2006) de l’auteur MurielBarbery a été effectuée afin de comprendre les liens qu’il y a entre les spécificités dumode narratif et leurs effets sur l’espace du récit, soit « le bocal à poissons », unemétaphore importante du roman. Ultimement nous répondons à la question suivante :En quoi la narration dans le roman L’Élégance du hérisson permet-elle de bien rendrela m...

  14. Le bien-être au travail en mutation chez les enseignants - une nouvelle approche guidée par la théorie culturelle et historique de l’activité

    OpenAIRE

    Launis, Kirsti; Koli, Annarita

    2014-01-01

    De nombreuses recherches ont révélé que le stress et l’épuisement au travail des enseignants sont en progression. Il s’agit manifestement d’un grave problème constituant une menace pour leur santé et leur bien-être. Au cours de cette étude, les chercheurs ont mesuré les diverses sollicitations exercées dans le travail d’enseignantes et présenté des propositions pour améliorer leur travail et ses conditions de réalisation. Ces propositions ont été prises en compte dans des programmes de format...

  15. HA TRAÍDO HASTA NOSOTROS DESDE TERRITORIO ENEMIGO, EL ALUD DE LA GUERRA: CONFISCACIÓN DE MAQUINARIAS Y APROPIACIÓN DE BIENES CULTURALES DURANTE LA OCUPACIÓN DE LIMA, 1881-1883

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    Milton Godoy Orellana

    2011-12-01

    Full Text Available El artículo analiza la confiscación de maquinarias y la apropiación de bienes culturales durante la ocupación chilena de Lima. Ambos temas en la producción historiográfica de la Guerra del Pacífico no han sido trabajados en profundidad, siendo negados o soslayados, aun considerando la evidencia documental existente en Chile. Basándose principalmente en estos repositorios documentales, los temas señalados son el motivo central del presente artículo, analizando la situación peruana, la participación de oficiales y representantes del Estado chileno durante la ocupación y la respuesta en Chile frente a la llegada de los barcos con bienes culturales -libros, estatuas u ornamentos para espacios públicos-, que varió desde el encubrimiento mediante el eufemismo, hasta la crítica de la prensa nacional y el rotundo rechazo por parte de la Cámara de Diputados de Chile.This article analyzes the confiscation of machinery and the appropriation of cultural goods during the occupation of Lima. Both themes have not been explored in depth by the War of the Pacific historiography, being neglected or ignored even considering the documented evidence that exists in Chile. Based mainly on those documents the article analyzes the Peruvian situation, the participation of Chilean officials and State representatives during the occupation, the answer in Chile facing the arrival of ships with cultural goods -books, statutes and ornaments for public spaces- that varied from the covering up through euphemism, to the critique from the national press and the categorical rejection on the part of the Chilean House of Representatives.

  16. Sexual risk and bridging behaviors among young people in Hai Phong, Vietnam.

    Science.gov (United States)

    Duong, Cong Thanh; Nguyen, Tran Hien; Hoang, Thi Thanh Ha; Nguyen, Van Vi; Do, Thi Minh Nguyet; Pham, Van Han; Detels, Roger

    2008-07-01

    The risk of the HIV epidemic spreading from high-risk groups to the general population in Vietnam depends on sexual risk and bridging behaviors between high- and low-risk individuals. A cross-sectional study was used to describe sexual activities of youth aged 18-29 years. Nearly half (41.4%) were sexually active. Premarital sex was reported by 43.3% of them; 78.3% of sexually active males and 13.5% of sexually active females. Multiple sex partners were reported by 31.0%; 56.7% of males and 9.2% of females. Almost 27% of males and 5% of females engaged in sexual bridging behaviors. Being unmarried was significantly associated with having sex with non-regular partners. Being unmarried and early age at first intercourse were associated with having sex with a sex worker. Consistent condom use was high with commercial sex workers but low with regular partners. Education to delay early sexual debut, increased employment, and strategies to inform young sexually active people to adopt safer behaviors are urgently needed.

  17. Síndrome de Rett: 50 años de historia de un trastorno aun no bien conocido Rett syndrome: 50 years' history of a still not well known condition

    Directory of Open Access Journals (Sweden)

    Jaime Campos-Castello

    2007-01-01

    Full Text Available Desde que fue descrito por primera vez por Andreas Rett hace 50 años, el síndrome de Rett (SR ha sido objeto de muchas investigaciones, sin embargo continúa siendo un trastorno aún no bien conocido. Presentamos nuestra propia experiencia y una revisión de la literatura sobre el SR. Se trata de un trastorno del neurodesarrollo, dominante ligado a X, que afecta casi siempre a mujeres, la mayoría de los casos de forma esporádica. El diagnóstico de SR debe hacerse en base a la observación clínica. Las principales características son la aparición de un retraso mental, cambios conductuales, estereotipias, pérdida del lenguaje y, sobre todo, del uso propositivo de las manos, aparición de una apraxia de la marcha, presencia de alteraciones de la respiración y, frecuentemente, crisis epilépticas. Los criterios diagnósticos consensuados internacionalmente son aquí revisados. El SR se debe en la mayoría de casos a mutaciones del gen MECP2, si bien una proporción de casos atípicos puede estar causada por mutaciones de CDKL5, particularmente la variante con epilepsia precoz. Sin embargo, los mecanismos patogénicos moleculares no son bien conocidos, así como la relación entre las mutaciones de MECP2 y otros trastornos del desarrollo. Revisamos también los hallazgos de neuroimagen, neuropatológicos y neurobioquímicos descritos en el SR. Respecto al tratamiento, aparte del sintomático, no hay ninguno que se haya mostrado eficaz. Un trabajo reciente abre perspectivas terapéuticas futuras al haber demostrado mediante un modelo animal de ratón la reversión de los síntomas neurológicos mediante la activación de la expresión de MeCP2.Since it was first described by Andrea Rett 50 years ago, Rett syndrome (RS has been the subject of further investigations, nonetheless it continues to be a not well known condition. Our own experience and an updated literature review on RS is presented. RS is a severe dominant X chromosome

  18. Valoración de bienes rústicos de utilidad pública: La expropiación forzosa por las obras del AVE en la provincia de León

    Directory of Open Access Journals (Sweden)

    María del Pilar Gutiérrez Flórez

    2010-06-01

    Full Text Available Con motivo de la expropiación forzosa de fincas en la provincia de León debido a las obras del Tren de Alta Velocidad, AVE, los propietarios de ochenta y dos fincas de los Ayuntamientos de Villanueva de las Manzanas, Santas Martas y Vega de Infanzones, solicitaron un estudio de valoración alternativo de las mismas para presentarlo, en forma de alegaciones individuales, al Jurado Provincial de Expropiación Forzosa de León, tal y como es su derecho, según la Ley de Expropiación Forzosa, LEF, por su desacuerdo con la oferta de la Entidad Expropiante.En este artículo se presenta el método, se justifican los criterios de valoración, se presentan y analizan los resultados obtenidos y se elaboran las conclusiones a partir de los informes individuales, tras el reconocimiento de los terrenos afectados y su entorno, en base a datos obtenidos bien sea de la propia entidad expropiante bien de la normativa autonómica en vigor en el momento de la expropiación, o bien de la Ley del Suelo 8/2007 en lo referente a la toma de decisiones para el planteamiento de las hipótesis de partida del estudio.Por último, se justifican la tasa del tipo de interés utilizado para la Capitalización de las rentas, en base a normativa vigente o estudios oficiales, y el coeficiente multiplicador del valor de las mismas, según los modelos territoriales de situación respecto a un núcleo urbano, ambos parámetros necesarios para determinar el valor de las parcelas.On the occasion of the necessary expropriation of lands in the province of León due to the works of the High-speed train, AVE (HIGH SPEED TRAIN, the owners of eighty two plots of Villanueva de las Manzanas, Santas Martas and Vega de Infanzones, requested an choice study of valuation of the same ones it to present, in the individual allegations, to the Provincial Juror of Necessary Expropriation of León, as it is your choice, according to the Spanish Law of Necessary Expropriation, LEF, for your

  19. "Parlez-Vous Bien Francais?" No Comment!

    Science.gov (United States)

    Dale, Mark; Liss, Mimi

    1996-01-01

    Describes an experience of introducing a "Records of Achievement" scheme in university extramural language courses. The article discusses the effectiveness of existing teaching/learning styles and examines the way in which records of achievement could foster autonomous learning. Student reaction to recording progress as a means of sustaining…

  20. Etica empresarial, responsabilidad social y bienes comunicativos

    OpenAIRE

    Calvo Cabezas, Patrici

    2014-01-01

    Since its beginnings, the conceptualisation of social responsibility has taken many forms, some of them related to philanthropy, patronage, strategy or business marketing among others. This paper defends the thesis that economic organization needs to manage those communicative goods, such as trust, reputation or reciprocity, evolved in the right development of their business activity and, therefore, on economic profit maximization. But for this, economic organization shou...

  1. La apropiación del dominio público y las posibilidades de acceso a los bienes culturales | The appropriation of the public domain and the possibilities of access to cultural goods

    Directory of Open Access Journals (Sweden)

    Joan Ramos Toledano

    2017-06-01

    Full Text Available Resumen: Las normas de propiedad intelectual y copyright prevén un periodo de protección otorgando unos derechos económicos exclusivos y temporales. Pasado un plazo determinado, las obras protegidas entran en lo que se denomina dominio público. Éste suele ser considerado como el momento en el que los bienes culturales pasan a estar bajo el dominio y control de la sociedad en conjunto. El presente trabajo pretende argumentar que, dado nuestro actual sistema económico, en realidad el dominio público funciona más como una posibilidad de negocio para determinadas empresas que como una verdadera opción para que el público pueda acceder a las obras.   Abstract: The legislation of continental intellectual property and copyright provide for a period of protection granting exclusive and temporary economic rights. After a certain period, protected works enter into what is called the public domain. This is often considered as the moment in which the cultural goods come under the control and domain of society as a whole. The present paper pretends to argue that, given our current economic system, the public domain actually functions more as a business opportunity for certain companies than as a real option for the public to access artistic and intellectual works.

  2. El trabajo independiente de los estudiantes de la asignatura Bienes de la Facultad de Derecho de la Universidad Simón Bolívar frente al aprendizaje autónomo

    Directory of Open Access Journals (Sweden)

    Ana María Ortega Gómez

    2015-10-01

    Full Text Available El presente artículo surge del desarrollo del trabajo de grado de la Maestría en Educación. Se pretende establecer de qué manera el trabajo independiente de los estudiantes de la asignatura civil Bienes del Programa de Derecho de la Universidad Simón Bolívar desarrolla el aprendizaje autónomo bajo el sistema de créditos académicos, ya que es importante obtener una visión más clara y una interpretación más crítica al interior del aula.Abstract The present article springs out from the development of the work of the Master Degree course in Education. It pretends to establish the way the independent work of the students of the subject of Civil Property at the law Program of the University Simon Bolivar develops the autonomous learning Under the academia credit system, as it is important to have a clearer sight and a better and more critical interpretation of the teaching room.

  3. LA QUIEBRA SIN BIENES: UNA APROXIMACIÓN DESDE EL ANÁLISIS ECONÓMICO DEL DERECHO Bankruptcy with no assets: An approximation from the economic analysis of law

    Directory of Open Access Journals (Sweden)

    Raúl Núñez Ojeda

    2011-01-01

    Full Text Available El presente trabajo trata de la quiebra sin bienes, esto es, de aquellos juicios en donde hay inexistencia o insuficiencia del patrimonio del fallido para afrontar los costos que supone la quiebra. En ambos supuestos, no se justifica económicamente dicho proceso. Sin embargo, nuestra legislación no contempla mecanismos apropiados para impedir el inicio o continuación de un juicio de quiebras en donde se acredite la inexistencia o insuficiencias de activos, los que se promueven, a pesar de sus altos costos, con la única finalidad de satisfacer la venganza de los acreedores, incentivados, estos últimos, por la posibilidad de perseguir criminalmente al deudor.The present paper is about the bankruptcy with no assets, that is, those trials where there is lack or insufficiency of the assets of bankrupt to face the costs of bankruptcy has involved. In both cases, no such process is economically justified. However, our legislation does not provide appropriate mechanisms to prevent the beginning or continuation of a bankruptcies trial in which it is established the absence or insufficiency of assets, which are promoted despite their high costs, with the only purpose of satisfying the revenge of creditors, motivated the latest by the possibility of prosecuting the debtor criminally.

  4. El fondo documental audiovisual de Radiotelevisión Valenciana: Evolución, transformación y Bien de Interés Cultural. Patrimonio Audiovisual de la Comunidad Valenciana

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    Alfonso-Noguerón, Lola

    2014-07-01

    Full Text Available El Col·legi Oficial de Bibliotecaris i Documentalistes de la Comunitat Valenciana (COBDCV, junto a la Associació Ciudadana i Comunicació (ACICOM han solicitado recientemente la protección de Bien de Interés Cultural (BIC, para los fondos documentales y archivo de Radiotelevisió Valenciana SAU y Radiotelevisión Española de la Comunidad Valenciana. En este texto se analiza, la evolución y transformación de los materiales audiovisuales creados por las empresas del que fuera el Grupo de RTVV a lo largo de los veinticuatro años de emisión. Se mostrará cual ha sido la evolución de este archivo y la situación actual de los materiales, de las bases de datos y del sistema de gestión de contenidos multimedia. Se identifican las razones, como la obsolescencia de los materiales audiovisuales y la precaria situación económica del país, para evidenciar que pese a la protección legal, es un objetivo continuar con la transformación y digitalización del archivo y fondo audiovisual más importante de la Comunidad Valenciana.

  5. Bien-être émotionnel au travail et changement organisationnel Emotional Well-Being at Work and Organizational Change: The Essilor Case Bienestar emocional en el trabajo y cambio organizacional : el caso de Essilor

    Directory of Open Access Journals (Sweden)

    Catherine Remoussenard

    2013-05-01

    Full Text Available Aujourd’hui, la plupart des entreprises mettent en place des projets de changements organisationnels afin de s’adapter aux modifications d’un environnement très concurrentiel. Ce faisant, elles se heurtent à des difficultés liées notamment aux situations de mal-être que ces changements peuvent induire. Notre étude vise à explorer les effets de nouvelles politiques managériales sur le bien-être émotionnel des salariés. Plus précisément, nous explorons les politiques mises en œuvre par un des sites du Groupe Essilor dans le contexte d’un changement organisationnel. Nous analysons d’un point de vue quantitatif et qualitatif les effets induits par ces politiques sur les salariés et sur la façon dont Essilor-Dijon en tient compte dans sa gestion des collaborateurs pour améliorer le bien-être au travail. À la lumière de nos résultats, il apparaît que les émotions sont au cœur de la conduite du changement, pouvant jouer le rôle de freins ou de leviers en fonction des choix managériaux.Nowadays, companies are implementing organizational change in order to be able to adapt to an increasingly competitive environment. Because of this context, firms are often confronted with problems linked to stressful situations that they themselves have brought about. We explored the policies which were applied by one of the branches of the Essilor Group in an organizational change context. First, we quantitatively and qualitatively analyzed the effects which this policy has had on stress-related issues. Second, we looked at how Essilor-Dijon took into account these effects in managing its staff so as to improve their well-being at work. Our results show that emotions appear to be at the heart of managing change and can either be obstacles or facilitators, depending on the choices made by management.Hoy en día, la mayoría de las empresas están llevando a cabo proyectos de cambio organizacional con el objetivo de adaptarse a las

  6. Opciones de conservación y liquidación de los bienes del deudor en el derecho uruguayo vigente: el caso de las sociedades anónimas

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    Eva Holz

    2014-03-01

    Full Text Available Incuestionablemente, del punto de vista empresarial, y los efectos de obtener el mayor valor posible en la realización de los activos de la sociedad anónima deudora en el procedimiento concursal, objetivo que precisamente satisface el interés de todos los acreedores- beneficiarios últimos del resultado de la liquidación -, la flexibilidad en las vías alternativas de realización activo es crucial. A partir de esa afirmación, qué opciones de liquidación son admisibles para nuestra vetusta legislación vigente (ley 2.230 de junio de 1893 y simultáneamente protegen a un eventual adquirente de la acción de los acreedores de la sociedad deudora? Desde ya anticipamos nuestra conclusión, en el sentido de que existen otras vías alternativas a la del remate para la liquidación de los bienes del deudor. Analicemos algunas, descartando desde ya todas aquellas vías que implican la adquisición de activos y pasivos, como podría ser la compraventa de acciones. De lege ferenda, el proyecto de ley de Declaración Judicial del Concurso y Reorganización Empresarial que cuenta con media sanción parlamentaria, determina con claridad que cualquiera sea el procedimiento de realización de los activos del deudor, el adquirente de los mismos no podrá ser perseguido por ninguna especie de acreedor de aquél

  7. El vivir bien, una propuesta de los pueblos indígenas a la discusión sobre el desarrollo (Living well, a proposal from indigenous people to the development discussion

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    Elisa Canqui Mollo

    2011-07-01

    Full Text Available ResumenÚltimamente hay una conciencia global sobre que la noción de desarrollo está pasando por serios procesos de crítica y reconstrucción, por las connotaciones evolucionistas y eurocéntricas predominantes en sus principales formulaciones, pensadas de cara a la construcción y ampliación de estados nacionales y de un proyecto económico y cultural dirigido a una progresiva modernización capitalista homogénea que busca la creciente satisfacción material e individual, fundada en formas que han amenazado con subordinar y transformar otros principios, culturas y conocimientos a su imagen y semejanza. Es en este marco, que el Vivir Bien, propuesta por los Pueblos Indígenas viene a sumarse a las distintas propuestas que han ido saliendo en cuanto a desarrollo se refiere. Esta propuesta comprendida por ellos como una traducción de las formas y estilos de vida, en su simplicidad muestra una compleja articulación entre la vida de los indígenas, sus recursos naturales y el vínculo estrecho entre ambos, dentro de un territorio.AbstractIn recent times there is a global awareness of the fact that the notion of development is going through a process of criticism and reconstruction, due to the evolutionary and Eurocentric connotations in its formulation, which is oriented to the construction and expansion of nation-states and an economic and cultural project led to a progressive and homogeneous capitalist modernization, aimed at increasing individual and material satisfaction. Those forms have threatened to subordinate and transform other principles, culture and knowledge. In this context we find the proposal of the indigenous peoples of Living Well. This proposal, understood by them as a translation of forms and lifestyles, shows in its simplicity, a complex articulation between the life of indigenous, their natural resources and the close link between them within a territory.

  8. Suma Qamaña, vivir bien, el Ethos de la nueva constitución boliviana (Suma Qamaña, Living Well, the Ethos of the new Bolivian constitution

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    Fernández, Hugo

    2009-12-01

    Full Text Available Resumen: Este artículo expone algunos antecedentes que explican por qué se ha introducido la expresión Vivir Bien (Suma Qamaña y sus variantes en el texto constitucional recientemente aprobado en Bolivia. Entre ellos menciona los sorprendentes resultados electorales obtenidos por Evo Morales, que se sustentan en la emergencia y consolidación del pensamiento indígena, en la clara voluntad de adquirir poder político por parte de las organizaciones indígenas y en la necesidad de cambiar el ordenamiento jurídico existente, empezando por la Constitución. Identifica igualmente algunos elementos que caracterizan la resistencia a estos esfuerzos en el ámbito de las tierras bajas. A la pregunta de por qué era necesario cambiar la Constitución, responde que la anterior pretendía la integración de los indígenas despojándoles de su identidad. Por el contrario, la actual se caracteriza por una marcada impronta indígena al tratar los principios, valores y fines del Estado. Es allí donde aparece la expresión Suma Qamaña y otras equivalentes en otras tantas lenguas indígenas, que es necesario leer como el Ethos que inspira a la nueva Constitución y que debe guiar en la construcción del nuevo Estado.Abstract: This article presents some background explaining why the term Living Well (Suma Qamaña and it variants has been introduced in the recently approved Constitution in Bolivia. This includes surprising election results obtained by Evo Morales, which are based on the emergence and consolidation of indigenous thought, the intention of acquiring political power by indigenous organizations and the need to change the existing legal order, starting by the Constitution. Some factors of the resistance to these efforts in the area of the lowlands are also identified. The previous Constitution wanted the integration of the indigenous identity. On the contrary, the current Constitution takes the indigenous thought to discuss the principles, values

  9. The marble quarries of Macael. From “free and communal” to council property; Las canteras de mármol de Macael. De “libres y comunes a todos” a bienes municipales

    Energy Technology Data Exchange (ETDEWEB)

    Carretero Gómez, A.; Aznar Sánchez, J.A.

    2017-09-01

    The fate of the inhabitants of Macael has been closely linked to the production of marble from time immemorial. The scope of these resources transcended local borders during the latter part of last century; thus, in the last few years, the marble extracted from the surroundings of Macael accounted for over 40% of the national production, with Spain being one of the leading world producers of this ornamental rock. This paper analyzes the changes that have taken place in the quarry access system since 1573, when the town of Macael was surveyed, up to the present time. After many historical changes in which the people of Macael have had to fight for ownership of the quarries, both against private interests and public administration, the assets which were communal, and therefore freely accessible to the locals, became the property of the Local Council, which at present also holds the exploitation concession of the marble resources and the power to grant leases to entrepreneurs wishing to extract this mineral. [Spanish] La suerte de los habitantes de Macael ha estado unida al mármol desde tiempo inmemorial. El alcance del recurso desborda las fronteras locales: durante los últimos años del pasado siglo en el entorno de Macael se extraía más del 40% del mármol nacional, siendo España uno de los líderes mundiales del mercado de esta piedra ornamental. Este artículo analiza los cambios que se han producido en el sistema de acceso a las canteras desde 1573, año en el que se realizó el apeo de la villa de Macael, hasta la actualidad. Tras no pocas vicisitudes, en las que el pueblo de Macael ha tenido que defender la propiedad sobre las canteras, tanto frente a intereses particulares como de la administración pública, los bienes que eran comunales, y por ello de libre acceso para los lugareños, pasaron a ser propiedad del Ayuntamiento, que en la actualidad es también titular de la concesión de explotación del mármol, y la arrienda a los empresarios que

  10. Escalas bien formadas, palabras no bien formadasa y la dualidad de Christoffel

    OpenAIRE

    Domínguez Romero, Manuel

    2016-01-01

    La presente tesis analiza las escalas musicales generadas desde la perspectiva y las técnicas que ofrece la combinatoria algebraica de palabras. La noción de escala musical es una de las más primitivas: intuitivamente se puede reducir a un conjunto de notas ordenadas seg un la frecuencia de su fundamental (altura del sonido). Ya desde tiempos de la Escuela Pitagórica se vio que al pulsar una cuerda tensa, los sonidos que mejor suenan juntos, los más consonantes, están determinados por unas lo...

  11. La vente des biens nationaux à la fin du XVIIIe siècle, nouvelle donne pour la ville The sale of national assets at the end of the 18th century – a gift to the city

    Directory of Open Access Journals (Sweden)

    François Antoine

    2009-05-01

    Full Text Available À la fin de l’Ancien Régime, les villes des Pays-Bas gardaient les traits de villes médiévales sans ordre et faites d’entrelacs de rues et de ruelles. Le caractère corporatif de la production limitait la présence de grands ensembles industriels et les couvents et leurs jardins occupaient une grande partie de la superficie intra et extra muros des cités. Par ailleurs, l’Église était propriétaire d’un important parc immobilier de petites demeures adossées à des églises jusqu’aux importants refuges d’abbayes dominant dans les campagnes de vastes espaces fonciers. Durant la deuxième moitié du xviiie, les autorités habsbourgeoises menèrent une politique tendant à moderniser les villes en faisant, en autres, tomber les enceintes et en donnant une nouvelle affectation aux couvents contemplatifs supprimés. La Révolution française bouleversa ces ensembles urbains en libérant d’un coup une masse très importante de biens immobiliers qui appartenait à l’Église et en modifiant radicalement les modes de production par la suppression des corporations de métiers. La bourgeoisie principalement négociante réussi habilement tirer tous les profits de cette nouvelle donne. Cet effet d’aubaine contribua grandement à faire passer nos régions dans un nouveau stade de leur démarrage industriel.At the end of the Ancien Régime, the towns of the Netherlands retained the characteristics of medieval towns, without any order and consisting of warrens of streets and alleys. The corporative nature of production limited the presence of major industrial complexes and the monasteries and convents, together with their gardens, covered a large part of the urban areas both within and outside city walls. In addition, the church had important property holdings, ranging from small residential properties attached to churches to major abbey residences dominating vast countryside estates. During the second half of the 18th century, the

  12. El emprendimiento y el bien común: ¿competencias complementarias o excluyentes? O empreendimento e o bem comum: competências excludentes ou complementarias? Entrepreneurship and the common good: complementary or exclusive aptitudes?

    Directory of Open Access Journals (Sweden)

    Juan David Enciso-Congote

    2010-04-01

    Full Text Available Este trabajo propone un análisis comparativo entre los requerimientos de la formación de competencias para el emprendimiento y para el desempeño laboral, de acuerdo con el escenario que sirve de contexto a cada una de ellas. En el caso del desempeño laboral, se toma como punto de referencia la estructura burocrática descrita por Max Weber. En cuanto al emprendimiento, las raíces son antropológicas, la naturaleza humana, independientemente de cualquier referente cultural o histórico. Estas consideraciones proporcionan un marco de referencia para reflexionar sobre las dificultades conceptuales y pedagógicas que obstaculizan la construcción de una visión más inclusiva de lo público y del compromiso que debe tener un profesional con la búsqueda del bien común y, por tanto, de la responsabilidad que recae en la formación universitaria para procurar este cometido.Este trabalho propõe uma análise comparativa entre os requisitos para a formação de competências para o empreendimento e o desempenho no trabalho, segundo o cenário que fornece o contexto para cada um deles. No caso do desempenho de trabalho, toma-se como ponto de referência a estrutura burocrática descrita por Max Weber. Respeito ao empreendimento, as raízes são antropológicas -da natureza humana-, independentemente de qualquer referência cultural ou histórica. Estas considerações fornecem um quadro para refletir sobre os desafios conceituais e pedagógicos que dificultam a construção de uma visão mais abrangente do bem público, do compromisso dos profissionais em procura do bem comum e, portanto, da responsabilidade que se encontra no ensino universitário para garantir esse papel.This study proposes a comparative analysis between the requirements involved in building aptitudes for entrepreneurship and those for job performance, according to the scenarios that serve as the context for each of them. In the case of job performance, the bureaucratic structure

  13. Le projet HANS KAÏ : une approche communautaire visant à améliorer la santé et le bien-être grâce au soutien par les pairs

    Directory of Open Access Journals (Sweden)

    Alexandra Henteleff

    2018-01-01

    modèle HANS KAÏ. Bien que d’autres recherches soient nécessaires pour valider nos résultats, il semble que le modèle HANS KAÏ puisse être efficace pour créer un contexte permettant à la population locale de s’entraider en favorisant des choix de vie sains et en détectant de façon précoce les changements d’état de santé.

  14. Aplicación del índice pronóstico AGES para el tratamiento del carcinoma bien diferenciado de la tiroides Application of AGES prognostic rate for treatment of a well differentiated thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Gimel Sosa Martín

    2009-09-01

    Full Text Available INTRODUCCIÓN. En la actualidad la selección del tratamiento quirúrgico adecuado en pacientes con carcinoma diferenciado de la tiroides en etapas tempranas es controversial. La presente investigación tuvo el objetivo de describir y evaluar los resultados del diagnóstico y tratamiento de esta enfermedad en un período de 5 años. MÉTODOS. Se realizó un estudio observacional, descriptivo con elementos analíticos incorporados, y prospectivo para la recolección de información de los pacientes atendidos por presentar nódulo de la tiroides, en el ISMM «Dr. Luis Díaz Soto», entre enero del 2002 y diciembre del 2006. A estos pacientes con cánceres bien diferenciados en etapas I y II según la clasificación internacional de tumores, ganglios y metástasis, se les aplicó de forma retrospectiva el índice de pronóstico AGES. RESULTADOS. La muestra estudiada estuvo constituida por 73 pacientes, de los cuales 69 eran mujeres (94,5 %. Del total de pacientes estudiados, 42 presentaron tumores benignos (57,5 % y 31, malignos (42,5 %. De los 31 casos diagnosticados como carcinomas mediante parafina, 21 obtuvieron puntuación menor de 4 según el índice AGES (menor riesgo, y solo 11 de estos (67,7 % recibieron una cirugía conservadora de la tiroides. CONCLUSIONES. Existió una buena concordancia entre la biopsia por aspiración con aguja fina y la parafina, por lo que la primera se considera de valor en la exploración de un nódulo de la tiroides. El índice AGES no siempre fue tomado en cuenta para la selección del tipo de cirugía, con tendencia a la cirugía más radical. Las complicaciones mayores se asociaron con mayor frecuencia a la cirugía radical.INTRODUCTION: At the present times, the selection a suitable surgical treatment for patients presenting with an early differentiated thyroid carcinoma is a controversial question. The aim of present research was to describe and to assessment the diagnosis results and the treatment of this

  15. Se démarquer dans l’industrie du bien-être. Transnationalisme, innovation et indianité Standing out in the wellness industry. Transnationalism, innovation and indianness

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    Laurent Pordié

    2011-11-01

    Full Text Available L’industrie du bien-être se caractérise à la fois par un fort potentiel d’innovation dans le domaine thérapeutique et par une prétention à l’ancienneté de ces nouvelles thérapies. Cet article propose d’analyser ce paradoxe en étudiant les logiques à l’œuvre dans la construction d’une marque identifiant et distinguant Mango Spa, une chaîne indienne de centres de soins et de remise en forme. Il s’intéresse aux sens et aux implications de l’innovation thérapeutique dans le cas d’une firme qui revendique l’authenticité de ses traitements tout en puisant dans des ressources d’influences multiples afin de s’adapter à une clientèle cosmopolite. Ces services et ces produits fondent leur légitimité sur la tradition ayurvédique, mais ils doivent toutefois la défier afin d’acquérir leur propre visibilité. C’est ainsi que Mango Spa se démarque de ses concurrents. De nouvelles thérapies « indiennes » sont créées en mobilisant clients internationaux, thérapeutes de cultures disparates et industriels établis hors de l’Inde. La marque est produite au travers d’un faisceau complexe de relations transnationales. En examinant les forces globales et le caractère multidimensionnel de la production d’une marque indienne, cet article renseigne plus généralement sur la circulation et la transformation des idées, des objets et des pratiques.The wellness industry is characterized by both a high innovation potential in the therapeutic field and a claim to the antiquity of these new therapies. This article aims to analyze this paradox by studying the logic at work in the construction of a brand identifying and distinguishing Mango Spa, an Indian chain of health and fitness centers. Particularly interesting are the meanings and implications of therapeutic innovation in the case of a firm claiming the authenticity of its treatments while drawing on multiples resources and influences to adapt them to a

  16. Reciprocidad en sectores populares : La circulaciones de bienes materiales y simbólicos como estrategias de dominación legítima para la reproducción de diferencias sociales en una villa de la ciudad de Córdoba

    OpenAIRE

    Merino, Luis Francisco

    2012-01-01

    el siguiente trabajo exploratorio se propone describir los cambios que tuvieron lugar a partir del 2003 en la circulación de bienes y servicios, entre la referente comunitaria del comedor “La Divina esperanza para un niño” y los vecinos del sector este del “Bajo”. En este sentido, pretenderemos dar cuenta de la importancia del proceso de “apadrinamiento”, por parte de una ONG local, del comedor en la que su referente comunitaria pasa a ser un nexo fundamental entre la dirigencia política y lo...

  17. Report: Ozone Transport Commission Incurred Costs Under EPA Assistance Agreements XA98379901, OT83098301, XA97318101, and OT83264901

    Science.gov (United States)

    Report #2007-4-00068, July 31, 2007. We questioned $2,723,706 of the $9,042,706 in reported outlays because the recipient claimed unallowable outlays for contractual services, indirect costs, and in-kind costs.

  18. Une relativité bien particulière...

    NARCIS (Netherlands)

    Bais, S.

    2010-01-01

    La théorie de la relativité restreinte, initialement publiée par Einstein en 1905, a changé radicalement notre compréhension du monde. Les notions familières d'espace et de temps et d'énergie furent mises la tête à l'envers, et la bagarre avec les explications contre-intuitives de ces concepts,

  19. Capital social, bienes relacionales y bienestar subjetivo revelado

    OpenAIRE

    Membiela Pollán, Matías Enrique

    2016-01-01

    [Resumen] Los supuestos en los que se basa la teoría económica tradicional adolecen de realismo antropológico y se asientan en una simplificación del comportamiento humano. El capital social es un concepto aglutinador que afronta el problema del embeddedness o de la imbricación entre lo social y lo económico, esto es, el estudio de la aportación de la "dimensión social" (normas, valores, redes sociales, confianza) al hecho económico. En el presente trabajo desarrollamos una revisión crí...

  20. "Bien Educado": Measuring the Social Behaviors of Mexican American Children

    Science.gov (United States)

    Bridges, Margaret; Cohen, Shana R.; McGuire, Leah Walker; Yamada, Hiro; Fuller, Bruce; Mireles, Laurie; Scott, Lyn

    2012-01-01

    Young children's expected social behaviors develop within particular cultural contexts and contribute to their academic experience in large part through their relationships with their teachers. Commonly used measures focus on children's problem behaviors, developed from psychopathology traditions, and rarely situate normative and positive…

  1. Bien Préparer la prochaine quinquennale

    CERN Multimedia

    Staff Association

    2013-01-01

    2012 : une belle année pour la physique des particules Nous avons toutes et tous pu participer à la belle aventure de la physique des hautes énergies en 2012, la découverte, grâce au LHC d’une particule similaire au fameux boson de Higgs, pierre manquante à l’édifice du Modèle standard. Dans d’autres domaines, l’année 2012 a également été riche en performances exceptionnelles. Le Directeur général, son équipe et tous les Cernois peuvent être fiers de ces réalisations scientifiques et techniques extraordinaires. Les États membres ont montré leur soutien à l’Organisation en approuvant le budget 2013 et le plan à moyen terme jusqu’en 2017 pendant les Comités officiels de décembre 2012, malgré...

  2. Pêches, aquaculture et bien vivre en Bolivie : contributions à la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La consommation de poisson en Bolivie est parmi l'une des plus faibles au ... De 2011 à 2014, l'alliance PECES PARA LA VIDA (PPV –. Poissons pour la vie) a .... In: Proyecto Mejoramiento de la Legislación Para la Pesca y Acuicultura.

  3. Ciudades de madera. Patrimonio del sur, un bien reciclable

    Directory of Open Access Journals (Sweden)

    Edward Rojas V.

    1994-05-01

    Full Text Available Hace algunos años reflexionaba en una de las páginas del número especial (N° 12 de la Revista Arquitecturas del Sur, dedicado a la ciudad de Castro, que la arquitectura así como la fotografía en la medida en que son registros concretos de la acción humana tienen la cualidad de atrapar con su materialidad ese preciso instante de la historia de la que son productos.

  4. La buena fe en la concurrencia sobre bienes inmuebles

    Directory of Open Access Journals (Sweden)

    Gastón Fernández Cruz

    1987-12-01

    Full Text Available El presente trabajo representa una apretada síntesis de la tesis titulada "El Papel de la buena fe en la transferencia de la Propiedad Inmueble". con la que el autor optó el grado de bachiller eb  Derecho en la Pontificia Universidad Católica del Perú en diciembre de 1984. Su pretensión no es otra que dejar claramente establecido el rol que representa la buena fe dentro de un sistema consensual de transferencia de la propiedad. cuando el derecho se enfrenta a una situación de excepción ante sucesivas transferencias.realizadas por un mismo sujeto.

  5. Ética empresarial, responsabilidad social y bienes comunicativos

    Directory of Open Access Journals (Sweden)

    Patricio Calvo Cabeza

    2014-12-01

    Full Text Available Since its beginnings, the conceptualisation of social responsibility has taken many forms, some of them related to philanthropy, patronage, strategy or business marketing among others. This paper defends the thesis that economic organization needs to manage those communicative goods, such as trust, reputation or reciprocity, evolved in the right development of their business activity and, therefore, on economic profit maximization. But for this, economic organization should implement a social responsibility to live up to expectations at stake; that is, to take into account the ethical dimension that underlies it.

  6. Ciberciudadanía, cultura y bienes públicos

    OpenAIRE

    Álvarez, J. Francisco

    2009-01-01

    Net society is provoking dramatic changes in several aspects of our daily life as cultural traits, business and the more disparages spheres of privacy and social life. We must attend both to freedom of access and to new services generation because of the peculiar form public goods are raising in the Net. To supersede individual capability limitations and to diffuse digital and cultural gaps, electronic government could be a cultural decisive tool in this phase of cibersociety enhancement. Tec...

  7. Juntas de Temporalidades, agentes locales y acceso a los recursos agrarios. La cesión y venta de los bienes de los jesuitas en la campaña de Buenos Aires y la Banda Oriental de fines del siglo XVIII

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    María Valeria Ciliberto

    Full Text Available RESUMEN El estudio de la administración y aplicación de las temporalidades incautadas a los jesuitas en 1767 en las distintas regiones de Hispanoamérica ha destacado el peso determinante de las redes de vínculos locales en el acceso a los cargos y a la propiedad de estos bienes. Desde esta perspectiva la enajenación del patrimonio rural confiscado a la orden efectuada por la Junta de Buenos Aires ha merecido menor interés historiográfico. Nuestro trabajo se centra en el análisis de las operaciones de traspaso de usufructo y propiedad de las estancias de Areco y Las Vacas concretadas a fines del siglo XVIII. Nuestro propósito es identificar los diversos actores sociales intervinientes y avanzar en el análisis de las modalidades de gestión de las Juntas porteñas en un período en el que los cambios político-institucionales de la monarquía se articulan con un proceso regional de expansión agraria y de revalorización de los recursos productivos.

  8. Receita pública e bem-estar social nos municípios mineiros emancipados no período de 1988 a 1997 Hacienda pública y bien estar social en los municipios de minas gerais emancipados en el periodo de 1988 a 1997 Revenue and social welfare in the emancipated municipalitiesof minas gerais during the periods of 1988 to 1997

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo da Costa Reis

    2013-04-01

    Full Text Available O movimento de descentralizações política, administrativa e fiscal intensificado a partir de 1988 tinha como objetivo promover a transferência de poder, recursos e atribuições para os governos locais. Além disso, esse fenômeno impulsionou o processo de emancipação municipal com o intuito de aproximar o poder público da sociedade, promovendo a melhoria da prestação de serviços. Este estudo apresenta a análise das receitas públicas e do bem-estar social dos municípios mineiros emancipados no período de 1988 a 1997. Para tanto, utilizaram-se testes de médias no intuito de comparar o desempenho dos municípios emancipados com o desempenho de seus municípios de origem. Como conclusão, verificou-se que os novos municípios são beneficiados com as transferências governamentais e possuem a mesma capacidade de arrecadação tributária dos seus municípios de origem. Não obstante, isso não permitiu que os citados municípios apresentassem nível de bem-estar superior em relação aos municípios de origem, assim como maior eficiência na gestão desses recursos, uma vez que estão mais próximos dos usuários.El proceso de descentralización política, administrativa y fiscal intensificado a partir de 1988 tenía como objetivo promover la transferencia de poder, recursos y atribuciones para los gobiernos locales. Además, ese proceso ha impulsado el proceso de emancipación municipal de prestación de servicios. Este estudio presenta el análisis de las haciendas públicas y del bien estar social de los municipios de Minas Gerais emancipados en el periodo de 1988 a 1997. Para tanto, se han utilizado testes de medias con el objetivo de comparar el desempeño de los municipios emancipados con el desempeño de sus municipios de origen. Como conclusión, se ha verificado que los nuevos municipios son beneficiados con las transferencias gubernamentales y poseen la misma capacidad de recaudación tributaria de sus municipios de origen

  9. Rompiendo la “maldición de los vacíos fronterizos”: La construcción de la fisionomía urbana de Berlín a través de la “fachada bien ordenada” del viaducto ferroviario

    Directory of Open Access Journals (Sweden)

    Filipe Temtem

    2016-10-01

    Full Text Available El presente artículo se despliega sobre el análisis del viaducto ferroviario que atraviesa el centro de la capital alemana en la dirección este-oeste. Con ello se pretende descifrar las estrategias de diseño urbano vinculadas a la planificación elevada de la Stadtbahn, discurriéndose sobre la configuración de la fisionomía urbana del centro de Berlín a través de una “fachada bien ordenada”. Así se expone la construcción de una morfología lineal asociada a la infraestructura de transporte segregado, aclarándose el designio de proyectar la línea de tren como un edificio-viaducto, que subordina la composición del espacio público a los efectos escénicos de su frontón arquitectónico. A través de un levantamiento in situ se deja de manifiesto que dicho edifico tiene la capacidad de romper la “maldición de los vacíos fronterizos”, contrariando la destrucción de las vecindades que típicamente convierte la vía segregada en una frontera físico-social. Esto con la intención de despejar el valor que la arquitectura agrega a estas construcciones originadas como respuesta exacta a problemas concretos de tiempo y distancia recogida, alumbrando un campo de trabajo multidisciplinario cada vez más ineludible, donde el aporte de los arquitectos al problema de la infraestructura de transporte aparece aún como figura difusa.

  10. Comprometimento, bem-estar e satisfação dos professores de administração de uma universidade federal Comprometimiento organizacional, bien estar y satisfacción en el trabajo de los profesores de administración de una universidad federal Commitment, well-being and satisfaction of management professors at a federal university

    Directory of Open Access Journals (Sweden)

    Maria Teodora Farias Traldi

    2012-08-01

    Full Text Available As pesquisas sobre o comprometimento organizacional, o bem-estar e a satisfação no trabalho vêm sendo realizadas com êxito na área de Psicologia Organizacional. Novos estudos sinalizam uma possível interdependência entre estes construtos. O objetivo precípuo desta pesquisa foi investigar as relações entre comprometimento organizacional, bem-estar e satisfação no trabalho, através de um censo realizado com os 104 professores de Administração de uma Universidade Federal, com taxa de resposta de 78%. Trata-se de uma pesquisa de campo, explicativa-descritiva, possuindo caráter transversal e natureza quantitativa. Os resultados mostraram que os professores apresentaram bons níveis de realização no trabalho e afetos positivos prevalentes em relação aos afetos negativos; declararam-se satisfeitos no trabalho quanto à chefia, aos colegas e à natureza do trabalho. O comprometimento organizacional normativo foi o único que contribuiu para a explicação da satisfação com o salário. O comprometimento organizacional calculativo contribuiu para a explicação dos fatores satisfação com a chefia e satisfação com as promoções. Finalmente, o comprometimento organizacional afetivo foi o principal preditor do bem-estar e da satisfação no trabalho. Este trabalho contribuiu tanto para a produção acadêmica das áreas de Psicologia e Comportamento Organizacional, quanto para a tomada de decisão quanto às políticas de gestão dos professores pesquisados, na perspectiva de que docentes e discentes possam desfrutar de um melhor ambiente de aprendizagem e produção do conhecimento.Las investigaciones sobre el comprometimiento organizacional, el bien estar y la satisfacción en el trabajo continúan a realizarse con éxito en el área de la Psicología Organizacional. Nuevos estudios señalan una posible interdependencia entre estos constructos. El objetivo mayor de esta investigación fue estudiar las relaciones entre

  11. « Il faut qu’un party se sente bien faible quand il accepte et qu’il recherche de tels appuis ». Femmes, jansénisme et publicité à Paris au xviiie siècle

    Directory of Open Access Journals (Sweden)

    Nicolas Lyon-Caen

    2009-07-01

    Full Text Available Le jansénisme devient, au siècle des Lumières, une déviance publique et donnée à voir à travers les lieux de la Ville. La présence féminine est évidente mais varie selon lessources car l’influence féminine n’est pas simplement tacite, mais constitue bel et bien un droit reconnu et sanctionné par des usages. Les institutions urbaines d’ancien régime sont cependant résolument masculines et l’impuissance des femmes réside plutôt dans leur extériorité au langage de celles-ci, sans que cela les empêche de faire « comme les hommes ». Mais leur investissement effectif dans la cause janséniste pose de manière récurrente, et insoluble, la question de leur rôle politique dans une société de plus en plus travaillée par le problème de la représentation.Contrary to the idea that associates religious deviance or minority with secrecy, Jansenism offers a different case study. During the eighteenth century Jansenists made their deviance public throughout the city of Paris, the major manifestation of which being the pilgrimage to the tomb of Deacon François de Pâris. Even though women participated to the movement, different sources give little evidence, as female influence was not simply tacit, but indeed constituted a right acknowledged by uses. Yet, urban institutions membership was resolutely male, the impotence of women, in that case, can be explained by their being foreign to the discourse of municipal bodies, which did not prevent them from acting “like men”. Therefore, the effective female investment in the Jansenist cause regularly posed the insoluble problem of their political role in a society in which the issue of representation became crucial.

  12. La doble ruptura del equilibrio dinámico de la frontera viva colombo-venezolana: nuevos perfiles demográficos e impacto en bienes colectivos colombianos; A dupla ruptura de equilibrio dinâmico da frontera viva colombo-venezuelana: novos perfis demográficos e impacto em bens coletivos colombianos; Double rupture of the dynamic balance of the colombo-venezuelan live border: new demographic profiles and impact on colombian public goods

    Directory of Open Access Journals (Sweden)

    admin Alvarado Araque

    2017-07-01

    Full Text Available Resumen: Este texto presenta desde una perspectiva netamente teórica, las esperables consecuencias en la prestación de bienes y servicios colectivos que podría tener la actual coyuntura migratoria de la población venezolana hacia Colombia. Para esto, se describen las características que envuelven el proceso migratorio en particular y los perfiles migrantes, lo que permitiría entrever las posibles afectaciones sobre bienes colectivos, tales como: salud, educación y seguridad ciudadana. Palabras clave: migraciones, Venezuela, Colombia.   Resumo: Este texto apresenta desde uma perspectiva …, das esperadas consequências na prestação de bens e serviços coletivos que podem ter, a atual conjuntura migratória da população venezuelana até a Colômbia. Para isso, se descrevem as características que envolvem o proceso migratório em particular e os perfis migrantes, o que permitiría antever as possiveis consequências sobre bens coletivos, tais como: saúde, educação e segurança cidadã. Palavras-chaves: migração; Venezuela; Colômbia.   Abstract: This paper presents, from a purely theoretical perspective, the expected consequences in the provision of collective goods and services, that could happen in the current migratory situation of the Venezuelan population towards Colombia. In this way, we describe the characteristics that surround the migratory process in particular, and the migrant profiles, which would allow us to see the possible effects on collective goods, such as health, education and citizen security. Key words: Colombia, Venezuela, Migratory processes, Public goods.

  13. MORAL DE MERCADO VERSUS SEGURIDAD ALIMENTARIA: UNA APROXIMACIÓN DESDE LA ÉTICA DEL BIEN COMÚN MORAL DE MERCADO VERSUS ALIMENTAÇÃO SEGURA: UMA ABORDAGEM SEGUNDO A ÉTICA DE BEM COMUM MARKET MORALITY VERSUS FOOD SAFETY: AN APPROACH FROM COMMON GOOD ETHICS

    Directory of Open Access Journals (Sweden)

    Claudio Lara Cortés

    2001-01-01

    Full Text Available La persistencia del hambre en el mundo, a pesar de su insuficiente visibilidad en los medios de comunicación, replantea con urgencia la temática de la seguridad alimentaria. Actualmente los modelos y políticas económicas y las guerras son factores más importantes en el hambre que los desastres naturales o el decaimiento de la producción agrícola incriminados en otras épocas. También es claro que no es posible explicar el hambre por la escasez de alimentos en el mundo. Sin embargo, estas certezas no producen conductas y políticas coherentes, puesto que la lógica neoliberal impide, en particular, al Estado inmiscuirse en las reglas del mercado. Junto con el problema del hambre se acentúa la dependencia de muchos países de la Región respecto de la oferta alimentaria, generándose una verdadera inseguridad alimentaria. En este contexto convendría entender el problema de la seguridad alimentaria como un tema ético, en la perspectiva del bien común con objeto de reaccionar adecuada y oportunamenteA persistência da fome no mundo, apesar da insuficiente visibilidade nos meios de comunicação,obriga resgatar com urgência a temática da alimentação segura. Atualmente os modelos de políticas econômicas e as guerras são fatores mais importantes com relação a fome do que desastres naturais ou a queda na produção agrícola, estes incriminados como tal em outras épocas. Torna-se claro, também, ser impossível explicar a fome pela escassez de alimentos produzidos no mundo. Entretanto, estas certezas não produzem condutas políticas coerentes, já que a lógica neoliberal impede, em particular, o Estado de intervir nas regras do mercado. Ao lado do problema da fome, acentua-se a dependência de muitos países da América Latina com relação a oferta de alimentos, o que gera verdadeira insegurança alimentar para seus habitantes. Neste contexto convém considerar o problema da oferta de alimentos seguros como tema ético, dentro

  14. Hi-speed, Hi-fi, Hi-lights : a fast algorithm for the specular term in the Phong illumination model

    NARCIS (Netherlands)

    Overveld, van C.W.A.M.; Wyvill, B.

    1996-01-01

    The computational effort to render images with light sources and camera at infinity is less than with light sources at finite distance from the illuminated surface. On the other hand, in the case of an infinitely remote light source and camera, planar polygons don’t receive highlights. In this

  15. Tropical Forest Fire Susceptibility Mapping at the Cat Ba National Park Area, Hai Phong City, Vietnam, Using GIS-Based Kernel Logistic Regression

    Directory of Open Access Journals (Sweden)

    Dieu Tien Bui

    2016-04-01

    Full Text Available The Cat Ba National Park area (Vietnam with its tropical forest is recognized as being part of the world biodiversity conservation by the United Nations Educational, Scientific and Cultural Organization (UNESCO and is a well-known destination for tourists, with around 500,000 travelers per year. This area has been the site for many research projects; however, no project has been carried out for forest fire susceptibility assessment. Thus, protection of the forest including fire prevention is one of the main concerns of the local authorities. This work aims to produce a tropical forest fire susceptibility map for the Cat Ba National Park area, which may be helpful for the local authorities in forest fire protection management. To obtain this purpose, first, historical forest fires and related factors were collected from various sources to construct a GIS database. Then, a forest fire susceptibility model was developed using Kernel logistic regression. The quality of the model was assessed using the Receiver Operating Characteristic (ROC curve, area under the ROC curve (AUC, and five statistical evaluation measures. The usability of the resulting model is further compared with a benchmark model, the support vector machine (SVM. The results show that the Kernel logistic regression model has a high level of performance in both the training and validation dataset, with a prediction capability of 92.2%. Since the Kernel logistic regression model outperforms the benchmark model, we conclude that the proposed model is a promising alternative tool that should also be considered for forest fire susceptibility mapping in other areas. The results of this study are useful for the local authorities in forest planning and management.

  16. System 800xA - a control system for the next generation of power plants; System 800xA - Das Leitsystem der naechsten Kraftwerksgeneration

    Energy Technology Data Exchange (ETDEWEB)

    Bruns, H. [ABB AG, Mannheim (Germany); Lauxtermann, S. [ABB AG, Minden (Germany)

    2006-07-01

    The system 800 x A developed by ABB is a power plant control system that is capable of combining the latest technologies in this field with best-practice solutions and integrating the I and C equipment already installed in a plant. System 800 x A offers plant owners a future-oriented integration platform for process control and sub-station control systems on the basis of the new IEC 61850 standard. Through optimised integration and networking of information in combination with direct and context-sensitive information access, decision-taking processes and the analysis of disturbances are speeded up considerably. Consistent data structures, ranging from field data to plant management data, and a simplified system configuration can reliably lower the system operating costs and increase operational reliability for a long time. This consistent technology can integrate turbine automation, unit automation, and all sorts of control functions and thus create single-source automation solutions that are highly harmonised and easy to handle. (orig.)

  17. Confiscación de bienes eclesiásticos en Colombia. La contabilidad de la Agencia General de Bienes Desamortizados (1861-1888

    Directory of Open Access Journals (Sweden)

    Carlos Orlando Rico Bonilla

    2010-07-01

    Por lo tanto, el ensayo tiene por objeto retratar a partir de las correspondientes fuentes primarias y secundarias, el sistema contable de la desamortización, que junto con otros sucesos históricos, constituye el contexto en el que se desenvuelve la contabilidad gubernamental en Colombia y Latinoamérica.

  18. The discovery of glycine and related amino acid-based factor Xa inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Kohrt, Jeffrey T.; Filipski, Kevin J.; Cody, Wayne L.; Bigge, Christopher F.; La, Frances; Welch, Kathleen; Dahring, Tawny; Bryant, John W.; Leonard, Daniele; Bolton, Gary; Narasimhan, Lakshmi; Zhang, Erli; Peterson, J. Thomas; Haarer, Staci; Sahasrabudhe, Vaishali; Janiczek, Nancy; Desiraju, Shrilakshmi; Hena, Mostofa; Fiakpui, Charles; Saraswat, Neerja; Sharma, Raman; Sun, Shaoyi; Maiti, Samarendra N.; Leadley, Robert; Edmunds, Jeremy J. (Naeja); (Pfizer)

    2010-12-03

    Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with optimized N-substitution can greatly increase hydrophobic interactions in the FXa active site. Also, the substitution of a pyridone ring for a phenylsulfone ring in the P4 sidechain resulted in an inhibitor with enhanced oral bioavailability.

  19. Fragile X--a challenge to models of the mind and to best clinical practice.

    Science.gov (United States)

    Hay, David A

    2008-06-01

    Cornish et al. (2008, this issue) provide an excellent review of Fragile X a common but very complex cause of intellectual disability. They report on a cohort of such males of normal intelligence quotient (IQ) and socioeconomic status (SES), but who have deficits in selective attention and growing impairment in response inhibition. This paper has theoretical views for our models of the mind and clinical implications for families where Fragile X may never have been considered as a possible cause of some of the problems in male and female family members and possibly as well for other disorders such as attention deficit hyperactivity disorder (ADHD) and autism.

  20. Nous aimerions bien avoir une idée de génie

    CERN Multimedia

    Durrer, Ruth

    2005-01-01

    New observations and experiments show us today that cosmos is even more exotic than Einstein had envisaged. The authors, from Geneva University, explain how modern theoretical physics try to catch Universe (1½ page)

  1. Un bien necesario para la escritura: la competencia ortográfica

    Directory of Open Access Journals (Sweden)

    Davinia Rodríguez-Ortega

    2015-01-01

    Full Text Available El presente artículo pretende dar cabida a una exploración sobre la materia ortográ - fica, no solo en la actualidad, sino desde los primeros escritos que reclaman su impor - tancia para el correcto entendimiento a tra - vés de la palabra y el papel. A continuación, se repasan las propuestas de autores litera - rios de importancia como García Márquez o Juan Ramón Jiménez. La revisión continúa con un análisis de ejemplos extraídos de ma - nuales, para comprobar en qué grado lo que se dicta por ley y a través de la Academia se aplica en el aula. Finalmente, en estas pági - nas también encuentran lugar los estudios y teor ías de los investigadores en la materia, como voces expertas a las que es necesario atender.

  2. La muerte le sienta bien. Imaginario cultural y racionalidad modernizadora en el rito de la muerte

    Directory of Open Access Journals (Sweden)

    Francisco Simón Marín Naritelli

    2013-12-01

    Full Text Available En la contemporaneidad, la asunción de un modelo técnico-científico de desarrollo, efectúa transformaciones que inciden en los imaginarios culturales. La conciencia posmoderna, aquella expresión de “desarraigo de las formas y los hombres” en palabras de Renato Ortiz, daría cuenta de un cambio en las formas en que se expresan los ritos mortuorios. Un conjunto de problemas asoman como pertinentes: ¿cómo la razón técnica-científica – lo que Max Weber denomina “intelectualización” – ha expulsado la muerte de la vida social? Y en particular, ¿cómo esta “expulsión” se ve representada en manifestaciones estéticas? ¿Qué estrategias de hegemonía y resistencia son visibles, y cómo pueden constituir identidades?

  3. Efectos de integraciones de firmas en mercados de bienes homogéneos

    Directory of Open Access Journals (Sweden)

    Juan Pablo Herrera Saavedra

    2016-03-01

    Full Text Available This article models the potential effects of firm mergers on the price of a market for homogenous goods. The analysis is carried out according to two scenarios: a firms have similar levels of technology at their disposal and b a degree of heterogeneity is assumed between groups of firms. It is found that even when mechanisms are in place to favor efficiency in product supply, there is a risk that prices will increase.

  4. De la publicidad de “bien público” a la publicidad social en Argentina

    Directory of Open Access Journals (Sweden)

    José Luis Taricco

    2012-04-01

    Full Text Available En la Argentina el fenómeno de la denominada hoy publicidad social tiene una importante historia.En los últimos años ha recibido nuevos aportes y conceptos, de la mano de los procedimientos del Marketing Social y de la denominada Responsabilidad Social Empresaria.No es menos cierto que el contexto de crecimiento económico(al menos hasta ahora de los últimos años, volvió a dar impulso a las campañas sociales, tanto desde el sector privado apoyando a las ONG, cómo del propio Estado Nacional que incluyo muchos temas sociales en las estrategias de comunicación oficial.

  5. Le point sur les indices du bien-être national | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    21 janv. 2011 ... Aujourd'hui, de nouveaux indices perfectionnés tracent un portrait plus fouillé de l'état ... des progrès sur le plan économique, mais beaucoup de citoyens ne profitent pas de .... Tobacco Marketing — It's All Smoke and Mirrors.

  6. Programa de salud y bienestar “Vive Bien, Vive Más”

    OpenAIRE

    Baca Uriarte, Carol; Machicao Chacón, Yahaira; Noya Fernandez, Claudia; Valle Vargas, Giuliana

    2012-01-01

    RESUMEN: El impacto en la calidad de vida y el incremento constante en los gastos para el cuidado de la salud justifican la implementación de un Programa de Salud y Bienestar que ayude a cambiar la cultura, de una curativa y costosa a una de prevención; asimismo, cuando las organizaciones asumen su Responsabilidad Social Corporativa, es fundamental definir objetivos claros, planificar las estrategias y medir periódicamente los resultados (tanto en mejoras de la salud como en la reducción ...

  7. No hay mal que por bien no venga: el optimismo según Rousseau

    OpenAIRE

    Baranzelli, Dante A.

    2004-01-01

    El deísmo rousseauniano desestima la existencia del caos o del Mal general. Por el contrario, ve en el sistema del mundo un orden perfecto que obedece a la divina Providencia, identificada con la legalidad universal de la naturaleza. Mas con ello su intención no es despreciar el sufrimiento de los individuos. De hecho Rousseau reconoce y admite la presencia, e incluso la abundancia, de diversos males que afectan al hombre. ¿Acaso él mismo no es un claro ejemplo de ello?

  8. Jeter de nouvelles bases pour le bien de la jeunesse dans les pays ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    16 mars 2015 ... Le CRDI dote les établissements locaux de moyens pour qu'ils puissent aider les pays de la région à répondre aux attentes grandissantes de leurs jeunes citoyens. Afin de mieux comprendre dans quelle mesure les bouleversements en Tunisie et en Égypte ont modifié la donne pour les entrepreneurs, ...

  9. Crime Mapping , ou le réductionnisme bien intentionné.

    Directory of Open Access Journals (Sweden)

    Boris Beaude

    2009-05-01

    Full Text Available En 2008, le British Crime Survey fit remarquer que le risque d’être victime d’un crime est au plus bas depuis le lancement de son étude systématique en 1981. Il précisa à cette occasion que cette tendance est observable dans l’ensemble des pays développés. En Angleterre, la criminalité aurait baissé de 39% depuis 1997, dont 40% pour les crimes violents et 55% pour les cambriolages. 2 Ce constat questionne le traitement médiatique et politique de la criminalité qui, ...

  10. Une mesure différente du bien-être : l'indice du bonheur national ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    À la lumière de ces données, le Centre for Bhutan Studies publiera, en 2011, un indice du BNB quantitatif. Cette subvention permettra à l'OPHI d'assister le Centre dans la synthèse et l'analyse des résultats de l'enquête de 2010. L'objectif : assurer la validité et la reconnaissance internationale de l'indice du BNB de sorte ...

  11. La muerte le sienta bien. Imaginario cultural y racionalidad modernizadora en el rito de la muerte

    OpenAIRE

    Francisco Simón Marín Naritelli; Guillermo Jarpa Espinoza

    2013-01-01

    En la contemporaneidad, la asunción de un modelo técnico-científico de desarrollo, efectúa transformaciones que inciden en los imaginarios culturales. La conciencia posmoderna, aquella expresión de “desarraigo de las formas y los hombres” en palabras de Renato Ortiz, daría cuenta de un cambio en las formas en que se expresan los ritos mortuorios. Un conjunto de problemas asoman como pertinentes: ¿cómo la razón técnica-científica – lo que Max Weber denomina “intelectualización” – ha expulsado ...

  12. Bonheur et progrès : mesurer le bien-être au Bhoutan et au Canada ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    31 janv. 2011 ... Étant l'un des pays les moins développés, le Bhoutan s'inquiète de la mondialisation et il est déterminé à protéger sa spécificité culturelle. Il veut préserver ses valeurs sociales en les ancrant dans des termes que le monde entier pourra comprendre et respecter, c'est-à-dire en les quantifiant. En mesurant ...

  13. Il faut bien faire avec des bribes, hein! (You Have to Make Do with Scraps, Huh?)

    Science.gov (United States)

    Malandain, Jean-Louis

    1983-01-01

    Suggestions are made for structuring taped listening exercises to promote careful attention to various elements of spontaneous speech (speaker, speaker characteristics, tone, etc.), and to sensitize students to the usage of "hein" or other specific expressions. (MSE)

  14. Derechos humanos y comics: un matrimonio est-éticamente bien avenido

    Directory of Open Access Journals (Sweden)

    María Jesús Fernández Gil

    2014-07-01

    Full Text Available Este trabajo pretende rescatar y justificar el uso del cómic, en el sentido de Duncan y Smith, entendido como una forma de arte en la que todos los aspectos narrativos están representados mediante dibujos e imágenes lingüísticas encapsuladas en una secuencia yuxtapuesta de paneles y páginas, como una herramienta didáctica idónea para la educación en y la enseñanza de derechos humanos.

  15. La dignidad humana y el bien común como valores del profesional de la contabilidad

    OpenAIRE

    Agudelo, María V.; Viloria O., Norka

    2017-01-01

    Las actuaciones alejadas de la ética de los contadores públicos han ocasionado que se deteriore la confianza en su trabajo. Organismos reguladores, emisores e investigadores de la profesión concuerdan que reforzar las normativas son importantes, pero no suficientes. El profesional interpretará las leyes y normas, desde su espacio moral, impregnándolo de sentido para su vida. La propuesta, desde una investigación documental, se basa en reforzar en los profesionales dos valores: la dignidad hum...

  16. Criteria for feasibility, health and welfare assessment of requirement to use second and subsequent generations of non-human primates or animals from self-sustaining colonies in research Critères d’évaluation de la faisabilité, de l’incidence sanitaire et des répercussions sur le bien-être animal, relatifs à l'obligation future d'utiliser des primates non humains issus uniquement des animaux de deuxième génération et plus ou des animaux provenant de colonies d'élevage auto-entretenues pour la recherche expérimentale

    Directory of Open Access Journals (Sweden)

    David Smith

    2011-10-01

    Full Text Available The European Directive 2010/63/EU on the protection of animals used for scientific purposes requires that a feasibility study must be conducted by the European Commission to determine if all sourcing of non-human primates from parents bred in captivity (F2 or from self-sustaining colonies can be achieved. This study should also include an assessment of animal health and welfare. Prior to the initiation of the European Commission’s study, it was considered by EFPIA and FELASA that the criteria to be used in the feasibility, health and welfare assessment should be established by experts to help expedite such a study. This paper identifies those criteria which may be useful in making policy decisions on the confirmation or reconsideration of the timetable for implementation of the F2 requirement. A key requirement before a number of criteria can be assessed is the generation of base-line data relating to the supply and future demand of non-human primates and the health and welfare status of current breeding colonies supplying the European market. Three groups of criteria have been indentified, namely feasibility, science and research and welfare. Within each group, a number of parameters are defined and their rationale for inclusion, together with suggested information points, is discussed.La directive européenne 2010/63/EU sur la protection des animaux utilisés à des fins scientifiques exige qu'une étude de faisabilité soit conduite par la Commission européenne afin de déterminer si l’approvisionnement en primates non-humains à partir de géniteurs élevés en captivité (F2 ou de colonies d'élevage autosuffisantes, peut être possible. Cette étude devra également inclure une évaluation de la santé des animaux et de leur bien-être. Avant le début de cette étude par la Commission européenne, l'EFPIA et FELASA ont estimé que les critères à utiliser pour les évaluations de la faisabilité, de la santé des animaux et du bien

  17. The discovery and exploration of Hang Son Doong

    Energy Technology Data Exchange (ETDEWEB)

    Limbert, H.; Limbert, D.; Hieu, N.; Phai, V. V.; Kinh Bac, D.; Phuong, T. H.; Granger, D.

    2016-08-01

    Hang Son Doong is located in the Phong Nha Ke Bang Limestone Massif in Quang Binh Province, Central Vietnam. Cave exploration by British cavers has been continuous in this area since 1990. Hang Son Doong is part of the Phong Nha Cave system which runs from the southern end of the National Park near the Lao border to the final resurgence at Phong Nha Cave. (Author)

  18. 77 FR 17323 - Special Conditions: XtremeAir GmbH, XA42; Acrobatic Category Aerodynamic Stability

    Science.gov (United States)

    2012-03-26

    ... planform and is of composite construction. The engine is a Lycoming AEIO-580-B1A with a rated power of 315... can perform any of the maneuvers listed in the Aresti Catalog. Generally, the evolution of the... review and discussions with the manufacturer and civil aviation authorities. Discussion of Comments A...

  19. 76 FR 80829 - Special Conditions: XtremeAir GmbH, XA42; Acrobatic Category Aerodynamic Stability

    Science.gov (United States)

    2011-12-27

    ... gear, conventional low-wing planform and is of composite construction. The engine is a Lycoming AEIO.... Generally, the evolution of the ``unlimited'' types of acrobatic airplanes, with very low mass, exceptional... further FAA review and discussions with the manufacturer and civil aviation authorities. Applicability As...

  20. The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis : a multifaceted paradigm

    NARCIS (Netherlands)

    Borensztajn, Keren; von der Thusen, Jan H.; Peppelenbosch, Maikel P.; Spek, C. Arnold

    2010-01-01

    Introduction Activation of the coagulation cascade during liver fibrosis: a puzzling paradox Protease-activated receptors: the link between coagulation cascade activation and liver fibrosis Expression and distribution of human PAR-2 in normal and pathological liver tissue FXa signalling on PAR-2

  1. Magnetic studies of the S=1 Heisenberg chain [Ni(Pr(i)xa)(2)(pyr)](n)

    Czech Academy of Sciences Publication Activity Database

    Orendáčová, A.; Orendáč, M.; Trávníček, Zdeněk; Meisel, M. W.

    2003-01-01

    Roč. 196, č. 1 (2003), s. 278-281 ISSN 0031-8965 R&D Projects: GA ČR GA203/00/0152 Institutional research plan: CEZ:AV0Z5038910 Keywords : ANISOTROPY * COMPLEX Subject RIV: CE - Biochemistry Impact factor: 0.950, year: 2003

  2. El Impuesto a la Transmisión Gratuita de Bienes y su reaparición en Argentina

    Directory of Open Access Journals (Sweden)

    Héctor W. Nazareno

    2009-12-01

    Full Text Available El presente trabajo tiene por objeto repasar aspectos principales de este gravamen, habida cuenta su reciente instrumentación legal por la Provincia de Buenos Aires, después de más de 30 años de haberse derogado el mismo en todos los fiscos del País

  3. Des maladies, des biens, des guerres... et l'éthique en question: Note sur l'affaire Tierney

    Directory of Open Access Journals (Sweden)

    2003-01-01

    Full Text Available Presque trois ans après le début de l''affaire Tierney', controverse qui a fait couler beaucoup d'encre à l'exception notable du monde francophone, l'heure est venue d'en dresser le bilan (au moins provisoire. Cet article propose donc un résumé critique de cette singulière polémique: l'ouvrage Darkness in El Dorado et les réactions qu'il a suscitées sont ici examinés. Notre attention va plus particulièrement porter sur un thème central: la pénétration des objets manufacturés occidentaux parmi les Yanomami et ses - conséquences. Par l'étude de question dépassant cependant la seule 'yanomamologie'- la guerre indigène, la rétribution des informateurs, etc.-, cette focalisation permettra notamment de remettre en cause plusieurs conclusion de Tierney et de critiquer les sources dont il fait un usage abondant. Les conséquences de cette controverse pou l'éthique anthropologique seront finalement exposées. EPIDEMIAS, ARTÍCULOS MANUFACTURADOS, GUERRAS... Y LA ÉTICA EN DISCUSIÓN: NOTA SOBRE EL CASO TIERNEY. Casi tres años después del comienzo de la “polémica Tierney”, controversia que ha hecho derramar mucha tinta, con notable excepción del mundo francófono sobre el particular, ya es hora de hacer un balance al menos de caracter provisorio. Este artículo quiere proponer un resumen crítico de esta polémica: Darkness in El Dorado y los comentarios que ha originado están examinados. La atención está particularmente centrada sobre un tema esencial del libro: la introducción de artículos manufacturados occidentales entre los Yanomami y sus consecuencias. Con el estudio de temas que adelantan la ‘yanomamologia’ -la guerra indígena, la retribución de los informantes, etc.-, esta focalización puede, entre otras cosas, cuestionar las conclusiones de Tierney y criticar las fuentes utilizadas por este autor. Por último, las consecuencias de esta controversia para la ética antropológica están expuestas. EPIDEMICS, ITEMS, WARS... AND ETHIC UNDER DISCUSSION: A NOTE ABOUT TIERNEY AFFAIR. Since it first started over three years ago, the so-called “Tierney affair” has elicited a spectacular amount of commentary throughout the world. However, the French-speaking public has been poorly informed about the controversy surrounding Darkness in Eldorado and the reactions it provoked. This paper attempts to fill in this gap. Emphasis is placed on one of the book’s central themes: the consequences of the massive introduction of manufactured goods among the Yanomami. The validity of many of Tierney’s assumptions, as well as his questionable use of written sources, will be examined in the light of general Amazonian ethnology, especially regarding such questions as native warfare and the impact of informant retribution. The implications of this controversy for anthropological ethics is also highlighted here.

  4. Je veux bien, mais me citerez-vous? On publication language strategies in an anglicized research landscape

    Energy Technology Data Exchange (ETDEWEB)

    Desrochers, N.; Lariviere, V.

    2016-07-01

    The pressure to publish in science’s lingua franca is linked to a common belief that this choice will cause the research to be more readily indexed, accessed, read, used, and cited. However, the use of a national language can be marketed as a source of distinction for institutions located in countries or nations where English is not the primary language. This study looks to understand publication-language practices in the social sciences and humanities by examining the publication strategies of three nations, including a stateless nation: Germany, France, and Québec. The data were extracted from the Social Sciences Citation Index and the Arts & Humanities Citation Index and comprise 3.7 million articles, notes and reviews published between 1980 and 2014. The rise of English and decline of other languages is staggering and follows the same tendency in Germany and France, reaching just over 80% in each case. Québec differs slightly because the percentage of papers published in English was already quite high in 1980; nevertheless, the proportion has also risen, now reaching over 90%. Impact follows suit: for each of the three nations, papers published in English gather, on average, three times as many citations as they national-language counterparts. Given the reign of impact indicators and the symbolic capital granted to citations in the current scientific context, the data reveal that opting for English-centric publication strategies pays off. However, this raises questions fundamental to science, the symbolic capital associated with language, and the effects of language-based strategies on research. (Author)

  5. Jóvenes cristianos: ¿entre la polaridad del bien y del mal? El juego de la balanza

    Directory of Open Access Journals (Sweden)

    Betty Sánchez Sarmiento

    2000-10-01

    Full Text Available “Yo soy la herida y el cuchillo;¡Yo soy la bofetada y la mejilla¡¡Soy los elementos y la rueda, y la víctima y el verdugo”Baudelaire“I am the wound and the knife; I am the slap and the cheek; Iam the elements and the wheel, And the victim and the executioner.”Baudelaire

  6. The municipal wastes methanation, it is correct and desirable; La methanisation des OM, c'est bien et souhaitable

    Energy Technology Data Exchange (ETDEWEB)

    Verchin, J.C. [Club Biogaz, 75 - Paris (France); Deschaseaux, Ch.

    2004-03-15

    The biogas coming from methanation is a renewable energy source and then can take part in the fight against greenhouse effect. Two solutions exist to to fight against greenhouse effect: the control of energy consumption and the use of energies that do not emit carbon dioxide in atmosphere. There are three utilizations of methanation for different kind of waste: the methanation of biological wastes, then the methanation is associated to a composting; the methanation of residual domestic waste the composts of this type can be refused because of their content in heavy metals; the anaerobic pre treatment. (N.C.)

  7. Suivi de la santé et du bien-être dans la ceinture minière du Goa

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nancy Minogue

    CRDI : Stephanie Colvey. Les contrecoups de la prospérité : En Inde, des chercheurs ont mis au point des outils pour concilier les effets néfastes des activités minières ... et la question du dédommagement des agriculteurs;. • la qualité de l'environnement : les préoccupations relatives à la dégradation de l'air, de l'eau, des ...

  8. Book review of "Políticas Públicas como Objeto Social: Imaginando el Bien Público en el Desarrollo Rural Latinoamericano"

    NARCIS (Netherlands)

    C. Kay (Cristóbal)

    2010-01-01

    textabstractThis book has its origins in papers presented at the Seventh Congress of the Latin American Association of Rural Sociology (Associac¸a˜o Latinoamericana de Sociologia Rural, ALASRU) in 2006 in Quito. It is divided into three sections. The first is the most ambitious as it deals with some

  9. LE DÉTOURNEMENT DE FONDS OU DE BIENS DES BUDGETS DE L’UNION EUROPÉENNE

    Directory of Open Access Journals (Sweden)

    Alexandru BOROI

    2007-09-01

    Full Text Available The embezzling of European communities funds is an important problem included in all criminal legislations from the European countries. This approach has been developed both trough the embezzling of the obtained funds, and also through the embezzling of a specific legal interest. As to the financial communitarian interests in the expenses domain changing the destination of the obtained funds means to use these previously legally obtained funds for other purposes than those originally meant. In Greece and Ireland this fraud of illegal redirection of funds is one of the potential expressions of fraudulent behavior that is provided in specific laws or specific provisions in the criminal code through frauds related to aids and incentives. In these countries changing the destination for funds that cannot be regarded as aids or incentives is not subjected to the provisions of the criminal law unless it has the elements of the breach of trust. In criminal codes from Austria, Denmark, Germany, Italy, Luxembourg, Spain and Sweden this fraudulent behavior related to the change of destination for funds is provided in specific stipulations different from those related to the fraud committed either by presenting false, inaccurate or incomplete documents or statements, or by avoiding to present information. The French criminal law stipulates this change of destination for funds as a crime related to the breach of trust. Unlike the other member states, none of the Great Britain jurisdictions stipulates a specific crime related to this fraud of changing the destination for funds. As for the communitarian financial interests related to incomes, frauds in the field of changing the destination for a legally obtained interest has to be followed by the unlawful assignment of some funds or the unlawful retaining of these funds. At the same time the resources of the European communities budgets are diminished. In Denmark, Greece, Spain, Ireland and Luxembourg changing the destination for a legally obtained interest is one of the potential types of fraudulent behavior provided in the criminal law in respect of the communitarian incomes.In Germany, Italy, France, Netherlands, Austria, Portugal and Finland tax fraud, regardless of the unique regulation in one or more specific laws, related to the customs regulations and the VAT, is defined in such a way as the fraudulent behavior is defined by any avoidance to indicate any change in the circumstances that can lead either to the illegally obtained funds, or to the unlawful retaining of these funds. This will result in the illegal decrease of the communitarian resources. In Romania the criminal provisions related to the embezzling of funds or interests are included in the art.18, par. 1,2, 3, Law no.78/2000. This fraud is directed at the social relations correlated with the financial discipline within the EU. Compliance with this discipline means to use the funds and the legally obtained interests in compliance with the legal provisions in force. This crime consists of affecting the money or the legally obtained interests by changing the destination for these funds. The crime of embezzling funds consists of changing the destination of the money, hence using it for other purposes than intended. Unlike the embezzlement of legally obtained interests, the crime of embezzling funds does not necessarily imply that the money is legally obtained.

  10. La Protección de bienes culturales en el Tribunal Penal Internacional para la ex Yugoslavia

    Directory of Open Access Journals (Sweden)

    Marina Lostal Becerril

    2012-01-01

    Full Text Available Since the outbreak of the Balkan war, three major events have taken place in what regards the protection of cultural property in armed conflict: the adoption of the Statute of the International Criminal Tribunal for the Former Yugoslavia which gives this court jurisdiction to try crimes against cultural and religious property; the approval of the Second Protocol to confirm and upgrade the obligations of the "1954 Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict"; and, finally, the "2003 UNESCO Declaration concerning the Intentional Destruction of Cultural Heritage" motivated by the destruction of the Buddhas of Bamiyan in 2001. While the latter two instruments have been exhaustively examined in scholarly literature, no updated study of the ICTY case-law exists yet. In this paper I go through all such cases and underline the following idea: the interpretation of ICTY has given rise to an involution and an evolution vis-à-vis the treaty law for the protection of cultural property in armed conflict; as well as to a doctrinal revolution by linking the destruction of cultural and religious property to the crimes of persecution and genocide. Since the interpretation of the ICTY largely diverges from the treatment afforded to cultural property in treaty law, I conclude that the protection of cultural property in armed conflict has by now a double life: one conventional and one jurisprudential

  11. BIEN, UTILIDAD Y CONCIENCIA: ASPECTOS FUNDAMENTALES DE LA ÉTICA EN TERCERA PERSONA DE DAVID HUME

    Directory of Open Access Journals (Sweden)

    Juan Andrés Mercado

    2013-11-01

    Full Text Available Hume reacted against egoism, rationalism, teleology and the religious elements contained in moral proposals. He places feelings in first place along with the spontaneous generation of a legal order issuing from them. Yet, many texts of this philosopher point at the need of reconsidering order (and beauty, finality and the role of reason in the realm of actions. His brilliant description of virtues goes beyond what this alleged spontaneity propounds, but it does not supersede the spectator’s (“third person” perspective, and it also fails to provide away for the acquisition of the stable dispositions of character.

  12. La batalla del bien y el mal: «Patrocinio de ángeles y combate de demonios»

    Directory of Open Access Journals (Sweden)

    Tausiet, María

    2009-06-01

    Full Text Available Patronage of Angels & Combat of Demons was the eloquent title of a book published in 1652. According to its author, the book was ‘an illustration of the benefits conferred on men by guardian angels […], and also of the ploys and challenges of demons.’ Nevertheless the prominence of demons was much more obvious. It is important to notice that the treatise reflected the author´s intense experience in the mountains near Jaca during the time he spent as a parish priest, when a serious epidemic of demonic possession broke out. It was to last five years, and sixty-two women were allegedly affected.En 1652 salió a la luz un libro con el expresivo título de Patrocinio de ángeles y combate de demonios. De acuerdo con su autor se trataba de una «ilustración de los beneficios que hazen los angeles de la guarda a los hombres […], y también de las astucias y impugnaciones de los demonios.» No obstante, el protagonismo de los demonios era mucho mayor. No hay que olvidar que el tratado incorporaba la intensa experiencia vivida por el autor del libro en las montañas de Jaca durante su período como párroco al declararse una grave epidemia de posesión demoníaca que se prolongó durante cinco años y que afectó a sesenta y dos mujeres.

  13. ¿Hemisferio occidental dividido? O bien: ¿Hasta dónde llega México?

    Directory of Open Access Journals (Sweden)

    Marianne Braig

    2014-06-01

    Full Text Available Una vez más, el hemisferio occidental es objeto de redefiniciones. En las diversas construcciones del espacio, como lo expondremos más claramente abajo, se manifiestan importantes diferencias que resultan de las representaciones que se tengan del hemisferio como un todo común o escindido. En esa controversia corresponde a México, como tierra fronteriza entre el Norte y el Sur, como un mundo intermedio que no es claramente determinable geográficamente, un papel central. ¿Se desplaza del Sur el país –desde 1994 perteneciente al Tratado de Libre Comercio (TLC de Norteamérica y desde 2002 a la zona militar del Northern Command de EE.UU.– acaparado por Norteamérica, o experimenta Norteamérica una mexicanización (no sólo por los mexicanos, que, como teme Huntington, no sólo transforma el idioma y los hábitos lingüísticos, sino también la cultura, la política, la justicia y el comercio?

  14. ÉTUDE DE CAS — Inde : Suivi de la santé et du bien-être dans la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 janv. 2011 ... Mais ses effets, tant néfastes que favorables, sur la santé et le ... dans la région minière : si les effets sont néfastes ou favorables; .... ÉTUDE DE CAS — Équateur (les pesticides) : L'intoxication par les pesticides en Équateur.

  15. Concesión Sabio Caldas - Gimnasio Moderno Un caso de responsabilidad social, stakeholders y bien común

    OpenAIRE

    Pérez Illera, Natalia; Rivera-Rodriguez, Hugo-Alberto

    2010-01-01

    En la última década del siglo XX se comenzó a notar en el mundo cómo los valores y virtudes de la sociedad se veían opacados por el actuar de algunas compañías. Era normal escuchar cada semana noticias que hacían referencia a comportamientos antiéticos cometidos por los directivos de algunas prestigiosas empresas. Ante esta situación, el mundo empezó a despertar la necesidad de retomar los valores una vez más y a hacerlos parte no sólo de la enseñanza familiar sino también d...

  16. Análisis sectorial de los recursos intangibles: Implicaciones estratégicas para bienes y servicos

    OpenAIRE

    Juste, V. Bordonaba; Palacios, L Lucia; Redondo, Y. Polo

    2006-01-01

    Intangible resources management is a relevant issue in Marketing and Management perspectives because these resources provide companies with competitive advantages (Caves, 1996; Srivastava, Fahey and Christensen, 2001). Intangible resources management is considered a strategic key question in franchising. This research analyzes the factors that influence on the intangible assets transmission from the franchisor to new franchisees through an initial fee payment. Because of intangible asset accu...

  17. The non-nuclear legislation and the communal property; La legislacion no nuclear y el bien comun

    Energy Technology Data Exchange (ETDEWEB)

    Ciallella R, Norberto; Grancelli Cha, Nestor

    1996-07-01

    Since 1984, year in which the Bolson Municipality, Rio Negro province, declared the town a 'Non Nuclear Area', began to appear an abundant legislation that generically, it is know as 'Non Nuclear'. The provinces of Buenos Aires, Chubut, Formosa, La Pampa, Santa Cruz and Tierra del Fuego, have in their respective Constitutions non nuclear articles, while the provinces of Catamarca, Cordoba, Corrientes, Chaco, Entre Rios, Formosa, Rio Negro, San Luis, Santa Cruz, Santa Fe, Tierra del Fuego and Tucuman have sanctioned in their respective jurisdictions non nuclear laws. New projects of these laws are in consideration and treatment in the provinces of Catamarca, La Pampa, Mendoza, Santiago del Estero and Rio Negro. The present work compiles and analyzes the available information on this subject. Although the topic is not regulatory, it could have involved in the regulatory area in an eventual situation that could be presented between regulatory laws of federal and provincials reaches. This work describes the current situation and the probabilities consequences of the mentioned legislation. (author)

  18. De la comunicación - desarrollo a la comunicación para el vivir bien

    OpenAIRE

    Contreras Baspineiro, Adalid

    2014-01-01

    “La comunicación para el desarrollo ha seguido un itinerario de parentescos no resueltos en la teoría y de experiencias más intuitivas que sistemáticas en la práctica”. Así introdujimos un trabajo anterior: Imágenes e Imaginarios de la Comunicación – Desarrollo, que recuperamos en esta nueva aproximación a las relaciones entre Comunicación y Desarrollo, en la perspectiva de ir cerrando brechas en las deudas del desarrollo con la sociedad y de la comunicación con el desarroll...

  19. World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

    Science.gov (United States)

    Labay, Keith A.; Wilson, Frederic H.

    2004-01-01

    The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

  20. Modeling the reduction of gross lithium erosion observed under high-flux deuterium bombardment

    NARCIS (Netherlands)

    Abrams, T.; Jaworski, M. A.; Kaita, R.; Nichols, J. H.; Stotler, D. P.; De Temmerman, G.; van den Berg, M. A.; van der Meiden, H. J.; Morgan, T. W.

    2015-01-01

    Abstract Both thin (<1&#xa0;μm) and thick (∼500&#xa0;μm) lithium films under high-flux deuterium and neon plasma bombardment were studied in the linear plasma device Magnum-PSI at ion fluxes >1024&#xa0;m−2&#xa0;s−1 and surface temperatures <700&#xa0;°C.

  1. The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin

    LENUS (Irish Health Repository)

    Solayar, Gandhi N

    2011-10-28

    Abstract Background Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban) is a new anti-thrombotic drug for the prevention of venous thromboembolism in adult patients undergoing elective hip and knee replacement surgery. The aim of this in vitro study was to investigate the possible effects of rivaroxaban on osteoblast viability, function and gene expression compared to enoxaparin, a commonly used LMWH. Methods Primary human osteoblast cultures were treated with varying concentrations of rivaroxaban (0.013, 0.13, 1.3 and 13 μg\\/ml) or enoxaparin (1, 10 and 100 μg\\/ml). The effect of each drug on osteoblast function was evaluated by measuring alkaline phosphatase activity. The MTS assay was used to assess the effect of drug treatments on cell proliferation. Changes in osteocalcin, Runx2 and BMP-2 messenger RNA (mRNA) expression following drug treatments were measured by real-time polymerase chain reaction (PCR). Results Rivaroxaban and enoxaparin treatment did not adversely affect osteoblast viability. However, both drugs caused a significant reduction in osteoblast function, as measured by alkaline phosphatase activity. This reduction in osteoblast function was associated with a reduction in the mRNA expression of the bone marker, osteocalcin, the transcription factor, Runx2, and the osteogenic factor, BMP-2. Conclusions These data show that rivaroxaban treatment may negatively affect bone through a reduction in osteoblast function.

  2. Aerospace Physiologist, AFSCs 43AX, M11XXY, and M122XY (Formerly AFSCs 916X, 149XA, and 229XY)

    Science.gov (United States)

    1993-12-01

    need arises, such as during hyperbaric and hypobaric chamber operations and specialized aerospace physiology classroom training requirements. xi 7... Hyperbaric And Hypobaric Chambers Little Rock AFB AK High Altitude Airdrop Mission Support (HAAMS) Holloman AFB NM Centrifuge Training Travis AFB CA... hypobaric , or hyperbaric chambers, etc.). Representative tasks which show the differentiation in time spent on duties among the DAFSC officers are

  3. Magnetic phase diagram of Co(Cr1-xA lx) 2O4 (x = 0.0-1.0)

    Science.gov (United States)

    Padam, R.; Sarkar, T.; Mathieu, R.; Thota, S.; Pal, D.

    2017-08-01

    We report the role of Al substitution in the magnetic properties of spinel CoCr2O4 by means of temperature dependent dc and ac magnetization and heat capacity measurements. Various compositions (0.0 ≤ x ≤ 1.0) of polycrystalline Co(Cr1-xAlx)2O4 samples have been prepared by sol-gel processing and their crystal structure was investigated by X-ray diffraction which was found to crystallize in the normal cubic spinel structure. For x ≤ 0.1, the system exhibits multiple magnetic orderings (long range ferrimagnetic ordering TC, spin-spiral ordering TS, and lock-in transition TL), similar to that of the parent compound, CoCr2O4. However, all the compositions between x = 0.1 and 0.5 exhibit long range ferrimagnetic ordering below TC and also a short range order at low temperature. Spin-glass like ordering was noticed between x = 0.6 and 0.8 due to the diluted B-site occupancy, whereas the end compound CoAl2O4 (x = 1.0) shows antiferromagnetic behavior. On the basis of these results, we propose a magnetic phase diagram for the Co(Cr1-xAlx)2O4 series as a function of the Al content (x) and measuring temperature (T).

  4. Direct Integration of Red-NIR Emissive Ceramic-like An M6 Xi8 Xa6 Metal Cluster Salts in Organic Copolymers Using Supramolecular Interactions.

    Science.gov (United States)

    Robin, Malo; Dumait, Noée; Amela-Cortes, Maria; Roiland, Claire; Harnois, Maxime; Jacques, Emmanuel; Folliot, Hervé; Molard, Yann

    2018-04-03

    Hybrid nanomaterials made of inorganic nanocomponents dispersed in an organic host raise an increasing interest as low-cost solution-processable functional materials. However, preventing phase segregation while allowing a high inorganic doping content remains a major challenge, and usual methods require a functionalization step prior integration. Herein, we report a new approach to design such nanocomposite in which ceramic-like metallic nanocluster compounds are embedded at 10 wt % in organic copolymers, without any functionalization. Dispersion homogeneity and stability are ensured by weak interactions occurring between the copolymer lateral chains and the nanocluster compound. Hybrids could be ink-jet printed and casted on a blue LED. This proof-of-concept device emits in the red-NIR area and generates singlet oxygen, O 2 ( 1 Δg), of particular interest for lights, display, sensors or photodynamic based therapy applications. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. The Dermond vertical axis wind turbine : a suitable solution for remote sites; L'eolienne a axe vertical Dermond : une eolienne particulierement bien adaptee aux milieux isoles

    Energy Technology Data Exchange (ETDEWEB)

    Martel, P. [Genivar, Montreal, PQ (Canada); Dery, J. [Dermond Inc., Ada, MI (United States)

    2005-07-01

    A new prototype of a 100 kW truncated Darrieus type vertical axis wind turbine was put into service at the University of Quebec in Abitibi-Temiscamingue. The prototype was developed by Dermond Inc., a subsidiary of Mckenzie Bay International, and has been connected to the internal power distribution network at the University since October 2004. The Dermond turbine is well suited for isolated communities in northern Canada and is an important part of power management that competes with other small autonomous diesel powered systems. In addition to its simple and reliable mechanics, the innovative turbine is easy to install and maintain. It is omni-directional, and as such, is always oriented towards the wind. It is also equipped with an advanced electronic control system that addresses the problem of power quality in small autonomous networks. Since its installation, the prototype has met its performance targets and Dermond Inc. plans to market a new 200 kW wind turbine in 2006 with improved characteristics. Dermond Inc. is confident that this technology can penetrate the markets of remote areas, including northern communities and islands. This paper described the origins of the vertical axis technology and how Dermond Inc. improved upon it to include the possibility of integrating other energy sources or energy storage for additional power gains. 8 figs.

  6. La etapa de los bienes globales en salud, una perspectiva nacional The age of public goods in health, a national perspective

    Directory of Open Access Journals (Sweden)

    José Ángel Córdova-Villalobos

    2008-01-01

    Full Text Available Los efectos adversos del tabaquismo sobre la salud han sido ampliamente reconocidos desde tiempo atrás. A pesar de todo, el tabaquismo no parece disminuir, con las inevitables consecuencias sobre la morbilidad y la mortalidad de millones de personas. Tan sólo en este año la OMS calcula que cinco millones de personas morirán por esta causa. En México, 26.2% de la población entre 15 y 65 años fuma con regularidad y el consumo se incrementa entre los jóvenes y las mujeres. La OMS adoptó el Convenio Marco para el Control del Tabaco, ratificado por México, lo que llevó a la creación de la Ley General para el Control del Tabaco, un importante hito en la política sanitaria mexicana, que próximamente será promulgada y que se espera tendrá un efecto notable en la contención de la epidemia de tabaquismo en el país.Adverse health effects from smoking have been widely known for a long time. Nevertheless, tobacco use does not appear to decrease, and with it the inevitable consequences on morbidity and mortality for millions of people continue. This year alone, the WHO calculates that five million people will die from tobacco use. In Mexico, 26.2% of the population between the ages of 15 and 65 smoke regularly and consumption increases among youth and women. The WHO adopted the Framework Convention on Tobacco Control, ratified by Mexico, which brought about the General Law for Tobacco Control, an important milestone in Mexican sanitary policy. This law will soon be in force and is expected to have a notable effect on containing the smoking epidemic in the country.

  7. ¿Por qué existe el Estado y no más bien la anarquía? (El anarco-comunitarismo de Michael Taylor

    Directory of Open Access Journals (Sweden)

    Rivera, Juan Antonio

    1996-04-01

    Full Text Available Not available.

    Se expone la perspectiva anarco-comunitarísta de Michael Taylor, y se la distingue de la anarco-capitalista de autores como Murray Rothbard, David Friedman o, en menor medida, Robert Nozick. El anarco- comunitarismo de Taylor está sólidamente asentado en la teoría de juegos; concretamente, en los análisis dinámicos del Dilema del Prisionero. Sobre la base de estos análisis, a los que el propio autor ha hecho contribuciones sustanciales, se pone de relieve la inviabilidad práctica de una anarquía perfecta, sin controles sociales externos. Pero Taylor muestra que hay, con todo, lugar para un orden social sostenido en controles informales y ampliamente descentralizados, es decir, fundado en vínculos comunitarios, y que ésta ha sido la solución al problema del orden social durante la mayor parte de la historia de la especie. Se discuten luego las circunstancias que presumiblemente dieron lugar a la crisis y obsolescencia de la solución anarco-comunitarista y su sustitución por la respuesta institucional basada en la presencia del Estado. Se concluye el escrito ensalzando los méritos teóricos de Taylor pero poniendo en duda la validez de los presupuestos valorativos que animan sus modestas proposiciones de cambio social.

  8. Goods and services from the activities of the Constituyentes Atomic Center; Bienes y servicios derivados de actividades desarrolladas en el Centro Atomico Constituyentes

    Energy Technology Data Exchange (ETDEWEB)

    Hermida, Jorge D [Comision Nacional de Energia Atomica, General San Martin (Argentina). Centro Atomico Constituyentes

    2001-07-01

    Technologies developed and used at the Constituyentes Atomic Center (CAC) are applied in Argentina in different fields, such as seamless pipes industry, non-destructive testing and quality assurance, food industry, microalloyed steels, medicine, space activities, air pollution studies, etc. The CAC has also a wide program of technical assistance to the industry.

  9. Katimavik Participant's Manual, Book VIII, Nutrition and Well-Being = Katimavik manuel du participant, cahier VIII, l'alimentation et le bien-etre.

    Science.gov (United States)

    Crelinsten, Michael, Ed.

    The bilingual student manual focuses on the nutrition and well-being learning activity portion of Katimavik, a nine-month volunteer community service and experiential learning program for 17 to 21 year old Canadians. Providing participants with basic information and tools to assess and improve nutritional states and tie nutrition concerns into a…

  10. Inventario de bienes de Juan Martínez, escribano público de Jerez de la Frontera en la primera mitad del siglo XV

    Directory of Open Access Journals (Sweden)

    M.ª Belén Piqueras García

    2013-12-01

    Full Text Available The present study is centered in the analysis of the Inventory of valuable objects of Juan Martínez, Jerez de la Frontera notary public during the first half of 15th century; Persecuting to bring to light this document from notarial type, until now unpublished, that approached its content and diplomatic analysis.

  11. Tout cela est bien quelque chose: Digital Preservation Today: how European Commission programmes and policy have brought us here: Festschrift for Patricia (Pat Manson

    Directory of Open Access Journals (Sweden)

    Janet Delve

    2017-05-01

    Full Text Available Patricia (Pat Manson worked with the European Commission's (EC’s research programmes from the early 1990s, initially as project officer (December 1991-March 2003 and then as Head of Unit (April 2003-2011 for Cultural Heritage and Technology Enhanced Learning which was part of the Directorate General Information Society and Media. The unit focused primarily on research in digital libraries, digital preservation, and in the use of ICTs for improving learning, but was also involved in the development of the i2010 digital libraries policies and actions. Prior to joining the Commission, she worked in the UK providing a national advisory and market watch service to libraries on the use of new technologies. She is now Head of the Inclusion, Skills & Youth Unit of the EC’s Directorate General for Communication Networks, Content and Technology (DG CONNECT, where the unit’s goal is to ensure that citizens, especially youth and those at risk of exclusion, are best able to benefit from the Internet and have the necessary skills so to do. This article sets out Pat’s leadership of EC-funded Digital Preservation, and examines her legacy in terms of lasting best practices, contributions to standardisation activities etc.

  12. Les expériences de victimisation, la santé mentale et le bien-être de jeunes trans au Québec

    Science.gov (United States)

    Raymond, Guillaume; Blais, Martin; Bergeron, Félix-Antoine; Hébert, Martine

    2016-01-01

    Résumé Les normes traditionnelles de genre prescrivent l’adéquation de l’expression de la masculinité et de la féminité au sexe anatomique de naissance. Les personnes qui présentent des variations dans l’expression de genre sont sujettes à diverses formes de réactions sociales suggérant la réprobation (des regards désapprobateurs aux violences physiques) susceptibles d’influencer négativement leur santé mentale. Trente-sept (37) jeunes se décrivant comme trans ou en questionnement sur leur identité de genre ont été recrutés dans le cadre de l’enquête sur les Parcours Amoureux des Jeunes de minorités sexuelles du Québec. Leurs expériences de victimisation parentale et de victimisation basée sur la non-conformité de genre ainsi que des indicateurs de santé mentale (détresse psychologique, estime de soi) ont été mesurés. Afin de comparer les expériences de victimisation et l’état de santé mentale des jeunes trans, ils ont été appariés à 37 garçons et 37 filles cisgenres sur la base de leurs caractéristiques sociodémographiques. Des analyses de prévalence et un modèle acheminatoire ont été réalisés. Les résultats mettent en évidence que les jeunes trans sont plus susceptibles de présenter des scores cliniques de détresse psychologique et de faible estime d’eux-mêmes que leurs pairs cisgenres. La violence verbale parentale et la victimisation basée sur la non-conformité de genre influencent négativement l’estime de soi, ce qui en retour augmente la probabilité de vivre de la détresse psychologique. Les résultats appuient l’importance des interventions de soutien à la diversité sexuelle et de genre. PMID:26966849

  13. Savoirs experts et idiome quotidien. Biens et vertus de la conception participative des velos de quartiers à Trois-Rivières

    Directory of Open Access Journals (Sweden)

    Philippe Gauthier

    2010-11-01

    Full Text Available This paper analyzes the development of a public bike system initiated by a civic organization that treats participation as a core principle. The analysis shows that the satisfaction of the goals pursued through the adoption of participative principles, amongst which the respect of citizens' personal experiences in the design of their world, is a difficult task. The near identity between the system designed with the help of citizens and other systems offered by large industrial companies cast doubt on the capacity of the participative principles to produce outputs that would represent genuine alternatives to careless design. The difficulty stems from the willingness to take participatory procedures as necessary conditions to the realization of democratic ideals in modern liberal societies. Putting forward principles for their own sake drives us away from the ideals of liberal democracy that promote efficiency in the actions we adopt, over and above sole obedience to a common practice.RÉSUMÉDans ce texte, nous analysons la mise en place d’un système de vélos partagés à Trois-Rivières initié par un organisme faisant de la participation citoyenne son principe fondamental d’action. Cette analyse montre comment l’atteinte des objectifs poursuivis par l’adhésion à ce principe participatif, outre le respect de l’expérience du citoyen dans le développement de son milieu de vie, peut poser problème. La similarité entre le système de vélos conçu avec la participation des citoyens et les systèmes offerts par les groupes industriels met en question la capacité du principe de la participation à produire des solutions alternatives. La difficulté relèverait de la volonté de faire des méthodes participatives un principe nécessaire à la réalisation des idéaux démocratiques des sociétés libérales modernes. Promulguer l’obéissance à des procédures d’action communes, pour elles-mêmes, nous éloigne d’une conception libérale de la démocratie qui s’attache d’abord à l’efficacité de l’action, donc à la qualité de ce qu’elle produit, indépendamment des moyens mis en œuvre.

  14. Recettes pour la paix, les droits & le bien-être concoctées au sein de la Genève internationale

    CERN Document Server

    2015-01-01

    Cette diversité de recettes est une vitrine d’exemples du travail ainsi réalisé par les organisations basées à Genève, illustré sous une forme innovante, et incluant également des propositions de menus composés de trois plats élaborés par des Chefs cuisiniers exerçant dans des hôtels 5 étoiles sur la place de Genève.

  15. The study of cultural objects by nuclear and conventional techniques; Estudio de bienes culturales con tecnicas de caracterizacion nucleares y convencionales

    Energy Technology Data Exchange (ETDEWEB)

    Palacios, Tulio A [Comision Nacional de Energia Atomica, General San Martin (Argentina). Centro Atomico Constituyentes

    2000-07-01

    A survey is given of the techniques that are used at the National Atomic Energy Commission of Argentina for the characterization and study of cultural and archaeological specimens. A short history of these activities is also given. (author)

  16. BIENES Y SERVICIOS ECOSISTEMICOS DEL BOSQUE TEMPLADO: CANTIDAD-CALIDAD DEL AGUA Y CAPTURA DE CARBONO BAJO DISTINTOS ESCENARIOS DE USO Y MANEJO SILVICOLA.

    OpenAIRE

    Roberto Eduardo Godoy Borquez; Pablo Jorge Donoso Hiriart; Carlos Enrique Oyarzun Ortega; Leonardo Jorge Almonacid Muñoz; Pilar Carcamo Diaz; Maria Paz Hernandez Rodriguez; Evelyn Viviana Padilla Oyarzun; Daniela Silva Coronado; Gotz Palfner

    2005-01-01

    ECOSYSTEMIC GOODS AND SERVICES IN TEMPERATE FORESTS: QUANTITY-QUALITY OF WATER AND CARBON SEQUESTRATION UNDER VARIOUS SCENARIOS OF FOREST USE AND MANAGEMENT Goods and services generated by temperate forests are highly important for the environment at a local and global level, and have a significant economic impact at a domestic and international level. Among their benefits, 3 of them are increasingly important: production of wood and fibre, production of quality water and in big amounts, ...

  17. FACTORES DE ÉXITO EN PROVEEDORES DE BIENES MANUFACTURADOS DE LA SALMONICULTURA CHILENA SUCCESS FACTORS IN SUPPLIERS OF MANUFACTURES WITHIN THE CHILEAN SALMON INDUSTRY

    Directory of Open Access Journals (Sweden)

    Carlos Torres Fuchslocher

    2009-04-01

    Full Text Available Este artículo analiza, en base a un trabajo empírico, los principales factores a nivel de la empresa que han determinado el éxito de los proveedores locales de manufacturas, en términos de participación de mercado, en el cluster del salmón en Chile. La investigación envolvió un levantamiento de material empírico a través de 50 entrevistas, las cuales fueron evaluadas cualitativamente y por medio de un análisis econométrico de corte transversal, usando variables explicativas cualitativas. Los resultados destacan la especialización sectorial, la innovación en productos especializados para la industria y la cooperación horizontal, dentro de la estrategia de entrada; y la antigüedad de la empresa, la capacidad de innovación interna, la capacidad financiera (capacidad de otorgar crédito a clientes y bajo nivel de endeudamiento y la diversificación de la cartera productos, dentro de la competitividad previa, como determinantes del éxito de los proveedores.This article analyses the main factors at the firm-level which have determined the success, in terms of market share, of manufacture suppliers within the Chilean salmon industry. The analysis is based on data collected in an empirical research that included 50 interviews with suppliers. The data was evaluated through both a qualitative analysis and a cross section econometric analysis. The results show the importance of sectoral specialization, the innovation on specialized products for the aquaculture industry and horizontal cooperation within the entry strategy of firms, whereas the firm's age, the internal innovation capabilities, the own capital and the diversification of product portfolio were the main competitive factors before the entry.

  18. Del capitalismo de bienes al capitalismo de las emociones : un análisis del discurso de la publicidad bancaria peruana

    OpenAIRE

    Robertson Sotelo, Karem Lesly

    2016-01-01

    La sociedad contemporánea ha pasado de las formas de consumo tradicional, propias de un capitalismo de la producción, en que la publicidad tenía como finalidad informar acerca de los objetos o productos capaces de satisfacer las necesidades básicas de los consumidores, a un tipo de consumo simbólico, en el que la mercancía está destinada a la satisfacción de los deseos, de las emociones e, incluso, de la misma identidad (Baudrillard 1974, Jameson 1984). En este segundo tipo de ...

  19. LA VALORIZACIÓN DE LOS “BIENES COMUNITARIOS” EN LA RECONFIGURACIÓN GEOGRÁFICA DEL CAPITAL EN EL SURESTE MEXICANO

    Directory of Open Access Journals (Sweden)

    Diana Itzu Luna

    2011-12-01

    Full Text Available Normal 0 21 false false false ES-AR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} La extracción de recursos naturales, el control y uso de espacios estratégicos para ser valorizados como mercancías sigue siendo condición en la permanencia del sistema capitalista. En este artículo, se propone retomar categorías y discusiones de la teoría crítica de la economía política para indagar en un caso concreto las formas de desposesión, así como las estrategias de movimientos sociales ante la disputa socioterritorial del sureste mexicano. En el caso analizado, el estudio de las amenazas de desplazamientos forzados y el despojo de tierra de población indígena en resistencia nos lleva a poner sobre la mesa de discusión los mecanismos históricos de lo que Karl Marx llamó acumulación originaria. Hoy la Acumulación por Desposesión de David Harvey y el tema de “la renta de la vida” de Armando Bartra son cuestiones teóricas que sirven para indagar sobre lo político del Capital en la reconfiguración territorial. Siendo el despojo pasado presente requerimos conocer las formas de valorización de lo robado. Abordaré dos de los mecanismos en que se da la desposesión: Áreas de Protección Flora y Fauna y, el Programa de Reconversión productiva para incentivar las plantaciones de palma africana.

  20. VISOR GEOGRÁFICO PARA LA CONSULTA PÚBLICA DE LOS BIENES INMUEBLES PERTENECIENTES AL PATRIMONIO CULTURAL DE LA CIUDAD DE RIOBAMBA, PROVINCIA DE CHIMBORAZO

    OpenAIRE

    Mejía Calderón, Danilo Fabián

    2017-01-01

    The present research proposes implement a “Geographical Viewer for the Public Consultation of the Immovable Property Belonging to Cultural Heritage of the city of Riobamba, province of Chimborazo”. By applying Geographic Information System, SIG web platform, files given by Direction of Patrimony Management and Information from Ecuadorian Cultural Heritage Information System of INPC. The viewer structure begins with inventory consolidation, for which it will be used: the declaratory file, r...

  1. ¿Cómo carajos escribo bien un texto? Hacia la planeación, organización y presentación adecuada de un texto

    Directory of Open Access Journals (Sweden)

    JOSELYN CORREDOR TAPIAS

    2010-01-01

    Full Text Available Este artículo ofrece un recorrido por el tema de la planeación, organización y elaboración de un texto escrito. Ofrece elementos teóricos sobre tal tema y da a conocer algunas concepciones, acciones y actitudes inadecuadas, innecesarias o inconvenientes en cada una de las fases consideradas básicas y necesarias al elaborar un texto. Dichas actitudes inadecuadas se deducen del trabajo del autor, en el ámbito universitario de la Uptc, gracias a su experiencia docente al regentar asignaturas como: Proyecto Comunicativo I y II en Lengua Materna, Epistemología, Gramática, Metodología de la Investigación, Sociolingüística, lectoescritura, entre otras; así mismo, se tiene en cuenta lo observado en la cátedra de Competencias Comunicativas, asignatura en donde se puede apreciar-y trabajar-el desempeño escritural-dada la naturaleza de esta cátedra de estudiantes provenientes de diversos programas del Alma Máter. El artículo se cierra con unos corolarios que giran, principalmente, en torno de la planeación, la organización, la redacción y la presentación de un texto escrito. El artículo está pensado, diseñado y recomendado para estudiantes universitarios quienes cursen semestres iniciales de su carrera profesional, empero -con ciertos ajustes- puede servir de norte para estudiantes de semestres más avanzados.

  2. Las nuevas tecnologías en la información y comunicación: ¿para bien o para mal?

    Directory of Open Access Journals (Sweden)

    Lic. Emilce Castillo Obando

    1998-01-01

    Full Text Available Este artículo se ha elaborado con la finalidad de compartir algunas reflexiones alrededor de la trascendencia de las nuevas tecnologías de la información y comunicación en nuestras sociedades, debido a los riesgos culturales que plantean dichas tecnologías. Abordamos también los riesgos y efectos psicosociales y fisiológicos que puede producir el uso de estas tecnologías. También se hace una revisión de los planteamientos existentes a favor y en contra de las bondades de las nuevas tecnologías sobre todo para las naciones subdesarrolladas, así como la trascendencia de que los países cuenten con políticas que regulen su incorporación y uso.

  3. Grassroots Action Research and the Greater Good (La investigación acción de base y el bien mayor)

    Science.gov (United States)

    Rainey, Isobel

    2011-01-01

    This study examines the action research topics and topic preferences of two groups of grassroots teachers: active researchers, and potential researchers. The analysis of the topics appears to indicate that, over the past decade, action research at the teaching of English at the grassroots level to speakers of other languages has been principally…

  4. GEOGRAFÍA Y EDUCACIÓN INICIAL: bien educados los niños no respetan algunos límites para aprender

    Directory of Open Access Journals (Sweden)

    Natália de Fátima Sá

    2016-06-01

    Full Text Available El objetivo de este trabajo es presentar y discutir las principales conclusiones de la investigación realizada para ver si y cómo pueden ser abordados en la educación de la primera infancia nociones en relación con los planes de estudio de la geografía que contribuyen al aprendizaje de esta disciplina durante los primeros años de la escuela primaria. A partir del análisis de los documentos oficiales del plan de estudios para identificar las relaciones entre lo que se propone para la educación de la primera infancia y los contenidos curriculares para los primeros años de la escuela primaria, se desarrollaron las prácticas educativas con una clase compuesta por niños de entre 4 y 5 años de edad. Las actividades fueron parte de un proyecto de trabajo en curso en la escuela y se les permite un enfoque multiescala al espacio empleando diferentes lenguajes, principalmente dibujo infantil articulado con la oralidad, sino también imágenes de satélite, música, modelos tridimensionales, video animación. El estudio se basó en los conceptos y supuestos teóricos y metodológicos de la Teoría Histórico-Cultural, en particular las contribuciones de Lev S. Vygotski a la educación y el enfoque histórico-social a la investigación en este campo. Para tratar la educación de los niños como parte de la educación escolar básica, con una perspectiva afirmativa sobre el acto de enseñar, en este artículo agregamos contribuciones de la Pedagogía Histórico-Crítica propuesta por Dermeval Saviani. Los resultados de las actividades deserrolladas con las prácticas educativas en la escuela muestran que la capacidad de comprensión de los niños y las posibilidades de la enseñanza de la Geografía en el jardín de infantes son mucho más avanzadas que los límites impuestos por las concepciones que prevalecen en algunas propuestas oficiales del plan de estudios, así como por las formas predominantes de pensar y hacer la enseñanza en la escuela. O objetivo deste artigo é apresentar e discutir os resultados principais de pesquisa realizada para verificar se e como podem ser abordadas na Educação Infantil noções relativas a conteúdos curriculares de Geografia que contribuam para aprendizagens nessa disciplina durante os anos iniciais do Ensino Fundamental. A partir da análise de documentos curriculares oficiais para identificar relações entre o que é proposto para a Educação Infantil e os conteúdos do currículo para os primeiros anos do Ensino Fundamental, foram desenvolvidas práticas educativas com uma classe formada por crianças entre 4 e 5 anos de idade. As atividades integraram um projeto de trabalho em andamento na escola e possibilitaram uma abordagem multiescalar do espaço articulando diferentes linguagens, principalmente desenho e oralidade, mas também imagem de satélite, música, modelos tridimensionais, animação em vídeo. O estudo foi orientado por concepções e pressupostos teórico-metodológicos da Teoria Histórico-Cultural, particularmente as contribuições de Lev Vigotski para a Educação e a abordagem sócio-histórica da pesquisa neste campo. Para tratar da Educação Infantil como parte da educação escolar básica, com uma perspectiva afirmativa do ensino, neste artigo acrescentamos contribuições da Pedagogia Histórico-Crítica proposta por Dermeval Saviani. Os resultados das atividades desenvolvidas com as práticas educativas na escola demonstram que a capacidade de compreensão das crianças e as possibilidades do ensino em Geografia na Educação Infantil são bem mais avançadas do que os limites impostos por concepções predominantes em algumas propostas curriculares oficiais, bem como pelas formas predominantes de pensar e fazer o ensino na escola.

  5. Les directives anticipées des personnes atteintes d’une démence de type Alzheimer : Comment faire pour bien faire?

    Directory of Open Access Journals (Sweden)

    Perreault, Line

    2016-01-01

    Full Text Available The Law on End of Life Care is now effective in Quebec. This law provides for a system of advanced medical directives. Respecting advanced directives (AD issued in anticipation of incapacity can be a beneficial ethical way to ensure self-determination of the patient in a context where a person’s incapacity is total and of short duration (e.g., terminal cancer. But what about when the loss of decision- making abilities is gradual and spread over a long period of time, as is the case of people with Alzheimer’s type dementia (ATD? Although the cognitive decline associated with ATD legitimizes the use of AD to promote self- determination of these people, relying solely on a person’s wishes expressed verbally or in writing to their relatives or physician to guide care is an approach that can be ethically risky. A review of the literature on AD, a study of the clinical features associated with ATD, and a critical analysis of a fictitious clinical case will help demonstrate the need for developing a gradual approach to revalidate agreements that take into consideration the AD of the person with a ATD while weighing their wishes and views in real time, their current quality of life and that of their caregiver. The beneficial deployment of AD relies on the ability of the actors involved to consider this as a process of revalidation of agreements. This necessary paradigm shift will ensure that actualising the self-determination of people with ATD does not come at the expense of their dignity, safety and integrity. Such an approach remains to be developed and promoted for people with ATD in Quebec. Health policies that move in this direction, as well as specific normative benchmarks for this clientele, are needed rapidly in the current Quebec context, which is joining the development of a system of “advanced medical directives” with a Law on End of Life Care.

  6. Burocracia y eficiencia en la provisión de bienes públicos: un modelo espacial de competencia política

    Directory of Open Access Journals (Sweden)

    Georgina Soto Sotomayor

    2010-12-01

    Full Text Available This paper presents a spatial model of political competition exploring the effects of political competition on government performance, in the context of efficiency on the provision of public goods and the size of bureaucracy. In contrast with other arguments that sustain that there is a positive relationship between political competition and efficiency, this study’s main result shows that in any political-economic equilibrium political competition provides incentives for an excess of bureaucratic employment and an inefficient provision of public goods.

  7. Paula de Eguiluz y el arte del bien querer, apuntes para el estudio de la sensualidad y del cimarronaje femenino en el Caribe siglo XVII.

    Directory of Open Access Journals (Sweden)

    Adriana Maya.

    2002-07-01

    Full Text Available Paula de Eguiluz, like many other women of African ancestry born in the Caribbean, was obliged by the Inquisition to narrate her body, her emotions, her affections and her sexuality. Her testimonies manifest an untiring search for affection and reiterate the use of love magic so that others would be well loved. In the eyes of the inquisitors, women like Paula were “witches” and “sorcerers”. The declarations transcribed during the hearings that the Inquisition carried out against her shed light on two moments of her life. The first occurred in 1624 when she first appeared before the Tribunal of the Holy Office in the city of Cartagena de Indias. Paula was 33 years old and had recently been deported from Cuba. Accused of witchcraft, she was sentenced to wear a reconciliation habit, to 200 lashes, and to work in the city hospital. The second period developed 8 years later, in 1632, when the second process against her began. Paula was then 41 years old. During her eight years in Cartagena, she sold her knowledge of how to trap lovers and how to be well loved. Her clients were white women and free mulattas of the city who paid up to 50 pesos for her work. I wish to invite the reader to listen to Paula de Eguiluz say words that, although fragmented by the interpretation of the scribe, speak more of the condition of female slaves in the Caribbean in the 17th century than any of the stories of Sabbaths of witches that flew on broomsticks and devoured children that predominated in the minds of the judges. The fragments of her discourse will be interpreted from the perspective of the fugitive slaves, which means that knowledge of love and desire as well as the art of sensuality will become territories of freedom and autonomy for enslaved women.

  8. Comer bien, comer mal: la medicalización del comportamiento alimentario Eating well, eating poorly and the medicalization of eating behavior

    Directory of Open Access Journals (Sweden)

    Mabel Gracia-Arnaiz

    2007-06-01

    Full Text Available En este artículo se analiza el progresivo proceso de medicalización del comportamiento alimentario por el cual una buena parte de los motivos pragmáticos o simbólicos que articulan la selección y el consumo humano de alimentos se ha sustituido por otros de orden nutricional. La normalización dietética se ha concretado, en particular en los contextos de relativa abundancia de alimentos, en torno de la dieta equilibrada, un patrón alimentario basado en la restricción y promoción del consumo de ciertos alimentos y nutrientes -qué y cuánto comer- y en la prescripción de un conjunto de pautas relativas a cómo, cuándo y con quién hacerlo, y cuyos objetivos han sido no sólo regular los cuidados del cuerpo y la salud, sino promover, a su vez, un cierto orden social y ético.This article describes how the progressive process of medicalization of food is inscribed within a biomedical logic that attempts to substitute many of the economic, adaptative and symbolic reasons that have ethnographically and historically conditioned eating habits in all cultures, exclusively for reasons of a dietetic nature. According to this logic, most of the population of modern societies does not know how to eat because they are victims of or have been made ill by the current profusion of food. They must, therefore, learn how to eat well, which in terms of eating practices means eating a little of everything, in moderation and in a balanced way. The main aim of current nutritional education is to (reestablish a supposed dietetic normality as far as food consumed, quantities, number of intakes and meal structures are concerned.

  9. La industria del calzado española en la posguerra: los efectos del intervencionismo sobre una industria de bienes de consumo

    OpenAIRE

    Miranda Encarnación, José Antonio

    1994-01-01

    Editada en la Universidad Carlos III Después de la guerra civil de 1936-39, la economía española atravesó un largo período de estancamiento. Entre las causas que lo originaron destaca una política económica de carácter intervencionista especialmente desafortunada. A pesar de que los dirigentes del nuevo régimen dieron prioridad a la industrialización del país, pocos sectores industriales consiguieron desarrollarse. Este artículo muestra cuáles fueron los efectos de la política autárquica s...

  10. ¿Desarrollo o bien vivir?: rethinking the social role of the Intercultural University from the questioning of the Educational Effect

    Directory of Open Access Journals (Sweden)

    Inés OliveraRodríguez

    2014-01-01

    Full Text Available La institución educativa es el resultado de un orden social moderno-colonial, determinado por un saber eurocéntrico que responde a la lógica del capitalismo como orden mundial de poder. Prueba de esto son los debates en torno a la escolaridad que comprenden su función social desde la inserción eficiente de los sujetos en la sociedad. En el orden de las políticas públicas vigentes, la lógica del desarrollo humano es lo que sigue primando en los proyectos educativos nacionales. Esta problemática se agrava cuando se piensa en los contextos interculturales una vez que la lógica del capital, de la productividad y el crecimiento económico, no son parte de otras formas de ver el mundo. La interculturalidad como diálogo e interacción de universos simbólicos distintos exige la incorporación de otras epistemologías y lógicas escolares. Lo intercultural, desde las universidades Interculturales mexicanas, exige nuevas respuestas del sistema educativo formal; siendo que estas propuestas parecen aproximarse a la construcción de sociedades plurales capaces de incluir a todos y todas en los proyectos de vida. Considerando esto, la pregunta central para la reflexión que aquí se propone es: ¿cómo se puede pensar los efectos educativos en un contexto intercultural? Para esto hemos asumido la lectura crítica desde la teoría de la colonialidad del poder de Aníbal Quijano, para pensar la interculturalidad desde la inclusión verdadera de otras epistemologías que permitan pensar el mundo desde otros lugares y desde otros saberes.

  11. ¿Qué significa estar bien informado? Retóricas, percepciones y actitudes ante el problema del etiquetado de los alimentos transgénicos

    Directory of Open Access Journals (Sweden)

    JÓSEAN LARRIÓN

    2016-01-01

    Full Text Available En este trabajo realizo un estudio de caso de la controversia sobre el etiquetado de los alimentos transgénicos, centrándome en España y la Unión Europea. Inicialmente, comparo los discursos sociales que conciben el etiquetado fundamentalmente como un problema o como una solución. Después, analizo las principales respuestas legislativas y los aspectos concretos que en este ámbito siguen siendo polémicos. A continuación, expongo los límites del modelo del déficit cognitivo y el problema de establecer qué información es relevante o irrelevante. El trabajo concluye mostrando la presencia de las retóricas de la seguridad y el riesgo, y proponiendo un esquema de posiciones sociales ante el consumo de transgénicos, su etiquetado diferencial y el quehacer científico en nuestras sociedades.

  12. El Puerto de La Laja (Huelva, como Bien de Interés Cultural en la categoría de Sitio Histórico

    Directory of Open Access Journals (Sweden)

    Emilio Romero Macías

    2010-01-01

    de sol y playa para el conocimiento de otras culturas y como plan dinamizador de zonas que han sido afectadas por el declive de la minería en nuestra provincia. Parte del poblado del Puerto de La Laja se encuentra actualmente rehabilitado para su explotación como turismo rural, por lo que la arquitectura en cierto modo ha tratado de conjuntar la antigua disposición de las casas con las mejoras realizadas para este tipo de uso.

  13. Hacia un nuevo MOOC de lenguas. El caso de Habla bien, escribe mejor. Claves para un uso correcto del español

    Directory of Open Access Journals (Sweden)

    Mª. Ángeles Recio Ariza

    2017-11-01

    Full Text Available A new language MOOC, aimed at native Spanish speakers and foreign students with an advanced level, has been developed within the E-LENGUA Project to focus on the proper use of the Spanish language. The design is based on a cMOOC – xMOOC hybrid format and aims to combine a convenient and familiar structure with the necessary flexibility to allow for an independent and customized training, as well as a strong social component. Therefore, its ultimate goal is to develop a learning community where both types of speakers contribute significantly to make progress in language proficiency and in understanding how language works.

  14. Quatre éléments clés pour favoriser la santé et le bien-être pour tous ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 sept. 2017 ... Les intervenants impliqués dans la définition des ODD comme les institutions de recherche sur les politiques contribuent grandement à l'atteinte des ODD liés à la santé. Ils sont en mesure de mener des recherches rigoureuses en tenant compte des connaissances contextuelles et de faire participer les ...

  15. Come bien, camina y no se preocupe--eat right, walk, and do not worry: selective biculturalism during pregnancy in a Mexican American community.

    Science.gov (United States)

    Laganá, Kathleen

    2003-04-01

    Mexican American childbearing women appear to offer a healthy model for pregnancy. However, statistics suggest that they may be at increased risk for poor birth outcome as they acculturate to a U.S. lifestyle. An ethnographic study in Watsonville, California, examined the influence of acculturation on pregnancy beliefs and practices of 29 Mexican American childbearing women. Data from formal semi-structured interviews were submitted to content analysis. During pregnancy, women balanced well-documented, traditional Mexican cultural beliefs with the individualistic beliefs common to Anglo-Americans. Selective biculturalism emerged as a protective approach to stress reduction and health promotion. Stress reduction interventions as part of routine prenatal care have potential benefit for all pregnant women. Future research on cultural barriers to family-based social support during pregnancy is needed.

  16. Bien recolectada pero mal tratada. El manejo municipal de la basura en Ciudad Obregón, Hermosillo y Nogales, Sonora

    Directory of Open Access Journals (Sweden)

    Nicolás Pineda Pablos

    2007-01-01

    Full Text Available Este trabajo hace un acercamiento a la manera cómo los gobiernos municipales manejan la basura desde el punte de vista del enfoque denominado "gestión integral de los residuos sólidos". Para ello, primeramente se revisan el concepto y los tipos de basura, así como las características del modelo de gestión integral de la basura y algunas ideas sobre el papel de los "pepenadores". Posteriormente, se exponen los procesos de recolección y tratamiento de la basura, así como las actividades de reciclaje y pepena que se llevan a cabo en Ciudad Obregón, Hermosillo y Nogales en el estado de Sonora (México. El estudio muestra que los servicios de estas ciudades están abocados principalmente a la etapa de la recolección y no contemplan ni la reducción ni el reciclaje. De las tres ciudades, sólo Hermosillo ha emprendido actividades parciales de reciclado y promoción de la reducción. En lo que se refiere al tratamiento, únicamente Hermosillo cuenta con un relleno sanitario que funciona adecuadamente, mientras que en Nogales el relleno sanitario con que se cuenta se maneja como tiradero y Ciudad Obregón carece enteramente de un sitio adecuado para el confinamiento de la basura. Por último, se revisa la situación del reciclado informal que hacen los pepenadores y se sugieren medidas a fin de formalizar su labor.

  17. ¿Desarrollo o bien vivir? Repensando la función social de la Universidad Intercultural desde el cuestionamiento al efecto educativo

    Directory of Open Access Journals (Sweden)

    Inés Olivera Rodríguez

    2015-01-01

    Full Text Available The educative institution is the result of a modern-colonial socialorder determined by a euro-centric knowledge that responds to the logic of capitalism as a world order of power. the debates about schooling that understands its function as the efficient insertion of individuals into society are proof of this. In the order of current public policies, the logic of human development still rules over the national educative projects. this problem worsens when one considers intercultural contexts once the logic of capital, productivity, and economic growth are not the base of other ways of seeing the world. Interculturality as a dialogue and interaction of different symbolic universes demands the incorporation of other epistemologies and schooling logics. Thus, mexican Intercultural universities demand new responses from the formal educative system. these proposals seem to approximate to the construction of plural societies, capable of including everybody in life projects. the purpose is the construction of a true dialogue between forms of knowledge. therefore, the main question that is asked here is: how can educative effects be thought in an intercultural context? to answer it, I have made a critical reading of Anibal Quijano’s theory of the coloniality of power which gives an understanding of interculturality based on the real inclusion of other epistemologies that allow seeing the world from other angles and other forms of knowledge.

  18. Diagnóstico regional de gestión de inventarios en la industria de producción y distribución de bienes

    Directory of Open Access Journals (Sweden)

    Valentina Gutiérrez

    2008-01-01

    Full Text Available La brecha creciente entre la investigación y la práctica de la gestión de inventarios genera la necesidad de crear mecanismos de acercamiento, de modo que desde la investigación se ofrezcan alternativas de mejoramiento para gestionar la complejidad de los inventarios en cadenas de suministro. Este artículo presenta un diagnóstico de la gestión de inventarios de producto terminado, producto en proceso y materias primas, realizado con las medianas empresas del Valle de Aburrá, Colombia, en los sectores de alimentos, fármacos, plásticos y textiles. Los resultados evidencian las oportunidades de mejoramiento y confirman la necesidad de llevar las metodologías teóricas propias de la ingeniería a una aplicación más real que permita involucrar la dinámica de las cadenas de suministro regionales.

  19. Las licencias de uso de bienes digitales: el díficil equilibrio entre los intereses de los titulares de los derechos y los usuarios

    Directory of Open Access Journals (Sweden)

    Aurelio Lopez-Tarruela Martinez

    2006-07-01

    Full Text Available Esse artigo aborda as normativas aplicáveisàs licenças de uso de bens digitais. É possivelconstatar dois interesses opostos, assimnormatizados: Por um lado, as normas depropriedade intelectual favorecem os titulares dosdireitos em prejuízo da comunidade em geral e dosusuários em particular; por outro lado, a norma sobrecondições gerais da contratação e, principalmente, aproteção dos consumidores favorecem os interessesdos usuários de direitos. Assim, busca-se definir umequilibrio entre esses interesses, tendo em vista anatureza inovadora dos bens digitais.This article approaches normative theapplicable ones to the licenses of use of digitalgoods. He is possivel to evidence two opposinginterests, thus normatizados: On the other hand,the norms of copyright in general favor the bearersof the rights in damage of the community and theusers in particular; on the other hand, the norm ongeneral conditions of the act of contract and,mainly, the protection of the consumers favor theinterests of the users of rights. Thus, one searchsto to define a balance between these interests, inview of the innovative nature of the digital goods.

  20. Quando rey perdemos nunq[u]a bien nos fallamos. La muerte del rey en la Castilla del siglo XIII

    Directory of Open Access Journals (Sweden)

    Pérez Monzón, Olga

    2007-12-01

    Full Text Available This article deals with the funeral spaces of the Castilian kings during the 13th century, and the iconography of their tombs as the reflection of a political ideational system tending toward the sanctification of the monarchy. This elevation of royalty provoked an open conflict with certain members of the nobility and the royal family, as well as a political and artistic response.

    El presente artículo trata sobre los ámbitos fúnebres de los reyes castellanos durante el siglo XIII y la particularidad iconográfica de sus monumentos tumulares como reflejo de un ideario político tendente a la sacralización de la monarquía. El encumbramiento de la realeza provocó un abierto conflicto con determinados miembros de la realeza y la familia real y una respuesta política y artística.

  1. Family Incomes: Will Your Children Be as Well Off as Your? = Les revenue familiaux: vos enfants s'en tireront-ils aussi bien que vous?

    Science.gov (United States)

    Theilheimer, Ish, Ed.

    1993-01-01

    Against the background of recent radical changes in the Canadian economy, this issue of the Canadian journal "Transition" examines the question of parents' concerns for their children's economic futures. "Changes in Family Incomes and Labour Market Participation in Post-War Canada" (David Ross and Clarence Lochhead) charts…

  2. '¡Hable Bien M'Ijo O Gringo O Mx!': Language Ideologies in the Digital Communication Practices of Transnational Mexican Bilinguals

    Science.gov (United States)

    Christiansen, M. Sidury

    2018-01-01

    This article examines Facebook conversations between members of a transnational social network of US- and Mexico-born English/Spanish bilinguals. Extending Bourdieu's theory of language and symbolic power, the article uses the framework of language ideologies to explore how members establish identity and membership differently depending on whether…

  3. Th e rediscovery of the Redwood orpiment and a Th e rediscovery of the Redwood orpiment and a cocktail of plants macerates containing arbutin to cocktail of plants macerates containing arbutin to defeat the Arribas-Silvestre defeat the Arribas-Silvestre,s syndrome in a bien agée s syndrome in a bien agée upper class lady

    Directory of Open Access Journals (Sweden)

    Lorenzo Martini

    2017-10-01

    Full Text Available The Arribas-Silvestre’s syndrome is a sort of photodermatitis induced especially in elder (especially women when they use to put pure essences or fragrances directly onto their skin, take some medicaments and expose to sun rays periodically. The black spots are irreversible and are aesthetically unpleasant. Generally people tend to renounce to treat this disease, since it seems no remedy is available and strongest lotions or emulsions containing 2-5% of hydroquinone are banished and anyway perilous. Here I herald a simplest method using on alternate days an ancient orpiment to abrade black spots and a mix of herb macerates containing arbutin, apt to bleach the original brownish or black maculae.Results are amazing.

  4. Pathotype profile of Xanthomonas oryzae pv. oryzae isolates from North Sumatera

    Science.gov (United States)

    Noer, Z.; Hasanuddin; Lisnawita; Suryanto, D.

    2018-02-01

    The Bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most important diseases and has caused crop failure in rice crops. This pathogen infects the leaves in all plant growth phases. The purpose of this study is to investigation 10 Xoo isolates pathotype obtained from North Sumatra based on their interactions with 10 near-isogenic rice lines (NIL) of IRRI. The results showed that there are 6 pathotypes of virulence in North Sumatra, they are; pathotype I with incompatible interaction to all Xa genes, pathotype II with compatible interaction to Xa1 and Xa3 genes, while it has incompatible interaction to other genes, pathotype III with compatible interaction to Xa1, Xa5, Xa7, Xa8, Xa10 and Xa11 genes, but it has incompatible interaction to other genes, pathotype IV with compatible interaction to all Xa genes, pathotype V with compatible interaction to Xa1 gene and incompatible interaction to other genes, and pathotype VI with compatible interaction to Xa3 gene and incompatible interaction to other genes. Based on the resistant genes in each individual Xa2, Xa4, and Xa21 genes are the combination of Xa genes which are most suitable for use in the development of rice cultivars in North Sumatra.

  5. Deuterium-induced nanostructure formation on tungsten exposed to high-flux plasma

    NARCIS (Netherlands)

    Xu, H.Y.; De Temmerman, G.; Luo, G. N.; Jia, Y. Z.; Yuan, Y.; Fu, B. Q.; Godfrey, A.; Liu, W.

    2015-01-01

    Surface topography of polycrystalline tungsten (W) have been examined after exposure to a low-energy (38&#xa0;eV/D), high-flux (∼1.1–1.5&#xa0;×&#xa0;1024&#xa0;m−2&#xa0;s−1) deuterium plasma in the Pilot-PSI linear plasma device. The methods used were scanning electron microscopy

  6. Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly lutzomyia longipalpis, blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo

    Czech Academy of Sciences Publication Activity Database

    Collin, N.; Assumpção, T.C.F.; Mizurini, D.M.; Gilmore, D.; Dutra-Oliveira, A.; Kotsyfakis, Michalis; Sa-Nunes, A.; Teixeira, C.; Ribeiro, J.M.C.; Monteiro, R.Q.; Valenzuela, J. G.; Francischetti, I.M.B.

    2012-01-01

    Roč. 32, č. 9 (2012), s. 2185-2198 ISSN 1079-5642 R&D Projects: GA ČR GAP502/12/2409 Institutional support: RVO:60077344 Keywords : hematophagy * leishmaniasis * microcirculation * thrombosis * vector biology Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.338, year: 2012 http://atvb.ahajournals.org/content/32/9/2185

  7. Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism.

    Directory of Open Access Journals (Sweden)

    Ashis K Mukherjee

    Full Text Available The monocled cobra (Naja kaouthia is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A2 (PLA2; EC 3.1.1.4 is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s for the differences in anticoagulant potency of two acidic PLA2 isoenzymes, Nk-PLA2α (13463.91 Da and Nk-PLA2β (13282.38 Da purified from the venom of N. kaouthia.By LC-MS/MS analysis, these PLA2s showed highest similarity (23.5% sequence coverage with PLA2 III isolated from monocled cobra venom. The catalytic activity of Nk-PLA2β exceeds that of Nk-PLA2α. Heparin differentially regulated the catalytic and anticoagulant activities of these Nk-PLA2 isoenzymes. The anticoagulant potency of Nk-PLA2α was comparable to commercial anticoagulants warfarin, and heparin/antithrombin-III albeit Nk-PLA2β demonstrated highest anticoagulant activity. The anticoagulant action of these PLA2s was partially contributed by a small but specific hydrolysis of plasma phospholipids. The strong anticoagulant effect of Nk-PLA2α and Nk-PLA2β was achieved via preferential, non-enzymatic inhibition of FXa (Ki = 43 nM and thrombin (Ki = 8.3 nM, respectively. Kinetics study suggests that the Nk-PLA2 isoenzymes inhibit their "pharmacological target(s" by uncompetitive mechanism without the requirement of phospholipids/Ca(2+. The anticoagulant potency of Nk-PLA2β which is higher than that of Nk-PLA2α is corroborated by its superior catalytic activity, its higher capacity for binding to phosphatidylcholine, and its greater strength of thrombin inhibition. These PLA2 isoenzymes thus have evolved to affect haemostasis by different mechanisms. The Nk-PLA2β partially inhibited the thrombin-induced aggregation of mammalian platelets suggesting its therapeutic application in the prevention of unwanted clot formation.In order to develop peptide-based superior anticoagulant therapeutics, future application of Nk-PLA2α and Nk-PLA2β for the treatment and/or prevention of cardiovascular disorders are proposed.

  8. Study of the natural radiation background affected on the human body in some areas of Viet Nam

    International Nuclear Information System (INIS)

    Ngo Van Thanh

    2008-01-01

    The author had studied the natural radiation background in 68 districts belong 40 provinces and cities of Vietnam from 2002 to 2005. The estimated results clearly show that the average external irradiation dose levels and the average annual external radiation equivalent dose affected on the human body are 0.181± 0.0189 μSv/h and 1599 ± 171.8 μSv/year respectively, both are in normal limit; the highest levels are in Lai Chau district (Lai Chau province); the lowest levels are in Buon Ma Thuot city (DakLak province), Phuoc Son district (Quang Nam province), Tan An district (Long An province). The radon concentration in the human being and the average annual internal inhalation irradiation equivalent dose affected on the human beings are 26.9 ± 15.89 Bq/m 3 and 392.88 ± 231.99 μSv/year respectively; the maximums are in Nha Trang city (Khanh Hoa province), Bac Binh district (Binh Phuoc province); the minimums are in Vung Tau city (Ba Ria- Vung Tau province), Tan An district (Long An province), Rach Gia district (Kien Giang province). The terrestrial radionuclide concentrations in the cereals, foodstuffs (rice, meat, vegetables), water, earth and the average annual internal irradiation equivalent dose are 829.2 ± 38.06 Bq/kg and 229.3 ± 67.70 μSv/year respectively; the highest levels are in Phong Tho district (Lai Chau province), Dien Bien city; the lowest levels are in Dong Xoai district (Binh Phuoc province), Tan An district (Long An province). The average total annual natural radiation background effective equivalent dose level affected on the human body is 2206.9 ± 529.30 μSv/year; the highest levels are in Lai Chau district (Lai Chau province); the lowest levels are in Tan An district (Long An province). The 14 maps of Natural Radiation Background in several localized regions belong 40 provinces and cities of Viet Nam had been set up. These results can reserve for serviceman and public health in the both wartime and peacetime. (author)

  9. Zpráva o 22. bienálním setkání Mezinárodní společnosti pro studium behaviorálního vývoje (ISSBD 2012)

    Czech Academy of Sciences Publication Activity Database

    Millová, Katarína

    2012-01-01

    Roč. 56, č. 6 (2012), s. 609-609 ISSN 0009-062X. [22nd Biennial meeting of the International Society for the Study of Behavioural Development. Edmonton, 08.07.2012-12.07.2012] Institutional support: RVO:68081740 Keywords : 22nd Biennial meeting of the International Society for the Study of Behavioural Development * report Subject RIV: AN - Psychology Impact factor: 0.244, year: 2012

  10. Jouer pour apprendre : est-ce bien sérieux ? Réflexions théoriques sur les relations entre jeu (vidéo et apprentissage

    Directory of Open Access Journals (Sweden)

    Vincent Berry

    2011-05-01

    Full Text Available Cet article propose une réflexion théorique sur les relations entre jeu (vidéo et éducation. A partir d’une revue de la littérature et sur la base d’une recherche consacrée à l’étude des joueurs de « jeux de rôles en ligne massivement multijoueurs », ce texte met en avant la complexité dans les sciences de l’éducation à penser le jeu comme espace d’apprentissage et propose quelques éléments théoriques pour aborder cette problématique.

  11. El enriquecimiento sin causa y la acción in rem versó en materia de responsabilidad estatal por realización de obras, prestación de servicios y suministro de bienes sin contrato estatal

    Directory of Open Access Journals (Sweden)

    Jaime Luis Arias Fonseca

    2013-09-01

    Full Text Available This paper examines bibliographically and under a critical rationale method the principle of unjust enrichment and action de in rem verso especially for Government liability derived from provided services, asset provision, and the execution of construction works in favor of the Government without any existing formal contract or when there is a wrongful contract between the Government and the contractor, thus, causing impoverishment to the latter and a correlative unjust enrichment to the former. To that effect, a brief historical review of these principles is performed; their notions, requirements, and functional conditions established by jurisprudence are revised; and finally, the current stance of the Administrative Court on the implementation of the unjust enrichment thesis and the merits of the actio de in rem verso in terms of Government liability in the abovementioned events is pointed out.

  12. « Foin de ma barbe, si je n’ t’arrange une djellaba bien à ta taille ! ». Aspects de la dispute en pays berbère

    Directory of Open Access Journals (Sweden)

    Claude Lefébure

    2009-05-01

    Full Text Available Le champ clos de l’injure en pays d’oralité, c’est la dispute, la querelle verbale. Considérant l’ensemble des principaux groupes de parlers berbères, l’article examine donc d’abord les vocables porteurs de l’idée d’« agresser par le verbe » pour aboutir à cette observation que, comme dans d’autres langues, d’une famille différente même, ils ont partie liée avec l’idée d’« entamer un derme ». La littérature orale insiste : l’apex, depuis la bouche, blesse plus durablement qu’une arme de fer. Puis trois courts textes dûs à des locuteurs originaires des Ayt Sadden au Maroc, des Ayt Frah dans l’Aurès, des Irjen en Kabylie, sont scrutés pour ce qu’ils révèlent de la dispute en milieu berbère : un échange de paroles débridées et de formules figées associées à une gestuelle, dont l’association véhicule la menace physique et l’agression morale. Le corps est omniprésent, l’individu rapporté le plus souvent à sa lignée. Certains jeux verbaux s’assortissant dans le même milieu d’adresses et d’imprécations injurieuses, l’article y lit, pour finir, une propédeutique à la domestication des affrontements verbaux.

  13. Marcos GRADE de la evidencia a la decisión (EtD: un enfoque sistemático y transparente para tomar decisiones sanitarias bien informadas. 1: Introducción

    Directory of Open Access Journals (Sweden)

    Pablo Alonso-Coello

    2018-03-01

    Full Text Available Los médicos y quienes elaboran guías y políticas a veces pasan por alto criterios importantes, les dan un peso indebido o no usan la mejor evidencia disponible para informar sus juicios. Los sistemas explícitos y transparentes para la toma de decisiones pueden ayudar a garantizar que se consideren todos los criterios importantes, y que las decisiones estén basadas en la mejor evidencia disponible. El grupo de trabajo GRADE ha desarrollado marcos «de la evidencia a la decisión» (EtD para los diferentes tipos de recomendaciones o decisiones. El objetivo de los marcos EtD es ayudar a los paneles a usar la evidencia de una manera estructurada y transparente para informar las decisiones respecto de las recomendaciones clínicas, decisiones de cobertura sanitaria y recomendaciones o decisiones sobre el sistema sanitario o sobre salud pública. Los marcos EtD tienen una estructura común: formulación de una pregunta, evaluación de la evidencia y conclusiones. No obstante, existen diferencias entre los marcos para cada tipo de decisión. Los marcos EtD informan a los usuarios sobre los juicios que se han hecho y la evidencia que los apoya dotando de transparencia la base para las decisiones de los que tienen que tomarlas. Los marcos EtD también facilitan la diseminación de las recomendaciones y permiten a los decisores de otros ámbitos adoptar recomendaciones o decisiones, o adaptarlas a su contexto. El siguiente artículo es una traducción del artículo original publicado en British Medical Journal. Los marcos EtD se utilizan actualmente en el marco del Programa de Guías de Práctica Clínica en el Sistema Nacional de Salud, coordinado por GuíaSalud.

  14. Una interpretación metodológica sobre la incorporación de los bienes y servicios culturales al análisis económico

    Directory of Open Access Journals (Sweden)

    Luis Fernando Aguado Quintero

    2012-12-01

    Full Text Available Cultural goods and services are inputs to ‘produce’ the leisure commodity, which is called cultural experience in the household ‘production function’ framework. In economic thought, the origin of such modeling can be traced back to the role assigned to cultural goods and services in their contribution to a pleasant life, and to the inherent difficulty in two processes: the measurement of value and taste formation. Therefore, prestigious economists considered cultural goods to be of little interest. Also, such modeling is traced back in economic analysis to the discussion that incorporates leisure as object of analysis. This article contributes to the literature on cultural economics by integrating coherently and comprehensively economic thought with economic analysis in the particular case of cultural goods.

  15. ¿Por qué Leer Bien es Importante?: Asociación del Dominio Lector con Otros Aprendizajes Why Reading Well is so Important?: Association Between Reading Mastery and Other Learning Processes

    Directory of Open Access Journals (Sweden)

    Teresa Marchant

    2007-11-01

    Full Text Available Fundación Educacional Arauco1 (Fundar, a partir de los datos obtenidos en las evaluaciones de sus distintos programas e investigaciones, realizó un estudio en una muestra de 1782 alumnos de 2° a 8º básico de distintas regiones de Chile, evaluados entre los años 2001 y 2005, con el objetivo de analizar la asociación entre el Dominio Lector y el desempeño en otras áreas de aprendizaje. Los resultados de este estudio muestran una significativa asociación entre la Calidad de Lectura Oral de los alumnos y el dominio de distintas habilidades como comprensión lectora, vocabulario y redacción, el mejor uso de contenidos de lenguaje, matemática y comprensión del medio, además del desarrollo de la autoestima. Interesa compartir estos resultados para destacar la importancia de desarrollar tempranamente, junto con otras habilidades, el proceso lector de los alumnos y fortalecerlo hasta lograr su total dominio."Fundación Educacional Arauco (Fundar" using data from the evaluation of programs and research, from different counties of Chile during the years 2001 to 2005, conducted a study of 1782 students from first to eight grade, to analize the association between Level of Reading Mastery and their performance in other areas of learning. The results of this study show a significant association between the students level of "Oral Reading Quality" and their performance in different skills such as reading comprehension, use of vocabulary and writing, the management of contents in Language, Mathematics, History and Science, as well as with their level self-esteem. It is interesting to share these results in order to enhance the importance of early development of the student's reading process, together with other skills, and to strengthen it until they reach full mastery.

  16. Small suburban cities of Lille Metropolis for the well-being of metropolitan? / Les petites villes periurbaines de la metropole lilloise au service du bien-etre des metropolitains?

    Directory of Open Access Journals (Sweden)

    Laurène Wiesztort

    2016-09-01

    Full Text Available Cities, main biotope of the Man in the World, glean more and more agricultural lands and natural spaces beyond the distant peripheries. Historic processes such as the mass urbanization or the industrialization based on the exploitation of subsoil resources, have taken over many natural spaces that were destroyed or erased or exploited for economic purposes. The region Nord Pas-de-Calais (France has a rate of arti cialisation of the very high ground, it’s fragmented territory and upset by two world con icts and a intense mining period. So, today, meadows of three quarter of peoples of the region consider that there isn’t enough nature in the heart of their city. Within the framework of the métropolisation, this feeling is accentuated due to urban sprawl, which is more and more important. Since the 1990s, we speak about sustainable development as about a new philosophy that would lead us to a more balanced world between will economic, social, cultural and environmental policies. The region is very invested in the domain, because of the speci cities of its territory. The objective of this investigation was to account for forms that can take the environmental territorial policies and / or whose issues the welfare of citizens through new recreational spaces in nature. Are small towns “used” to ll the void nature of large cities ?. Methodologically, I have chosen to address this issue by studying the case of Lille Metropolis, relying on both eldwork four years during my thesis as well as on two inquiries which I led on the regional territory in 2006 and 2011. This research has helped to highlight the medium-sized cities, small towns and rural municipalities play a major role in territorial policies such as green and blue weft. They are the key to meet the demand of urban natural spaces. Taking this into consideration, the region will thinking about the nature of hearts with many vocations: ecological (biodiversity reserves, social (parks and recreation, economic (activities and cultural (tourism, heritage. Cities, main biotope of the Man in the World, glean more and more agricultural lands and natural spaces beyond the distant peripheries. Historic processes such as the mass urbanization or the industrialization based on the exploitation of subsoil resources, have taken over many natural spaces that were destroyed or erased or exploited for economic purposes. The region Nord Pas-de-Calais (France has a rate of arti cialisation of the very high ground, it’s fragmented territory and upset by two world con icts and a intense mining period. So, today, meadows of three quarter of peoples of the region consider that there isn’t enough nature in the heart of their city. Within the framework of the métropolisation, this feeling is accentuated due to urban sprawl, which is more and more important. Since the 1990s, we speak about sustainable development as about a new philosophy that would lead us to a more balanced world between will economic, social, cultural and environmental policies. The region is very invested in the domain, because of the speci cities of its territory. The objective of this investigation was to account for forms that can take the environmental territorial policies and / or whose issues the welfare of citizens through new recreational spaces in nature. Are small towns “used” to ll the void nature of large cities ?. Methodologically, I have chosen to address this issue by studying the case of Lille Metropolis, relying on both eldwork four years during my thesis as well as on two inquiries which I led on the regional territory in 2006 and 2011. This research has helped to highlight the medium-sized cities, small towns and rural municipalities play a major role in territorial policies such as green and blue weft. They are the key to meet the demand of urban natural spaces. Taking this into consideration, the region will thinking about the nature of hearts with many vocations: ecological (biodiversity reserves, social (parks and recreation, economic (activities and cultural (tourism, heritage.

  17. Comment évaluer la valeur sociale d'un bien? D'une définition substantive à la construction sociale d'une procédure de qualification

    OpenAIRE

    CARATY , Mélodie; Chanteau , Jean-Pierre

    2016-01-01

    International audience; Les stratégies de responsabilité sociale des entreprises (RSE) conduisent certaines d'entre elles, comme ArcelorMittal, à se demander quelle est la ‘valeur sociale' de ses produits. Pour définir ce qu'est la valeur sociale, nous nous appuyons sur la littérature scientifique en économie dans laquelle le concept de ‘valeur' est une question canonique. Une définition objective de la valeur sociale ne peut être fournie puisqu'elle résulte d'un jugement collectif issu d'int...

  18. "Me urge se me suministre de sus bienes los alimentos": estrategias femeninas en la resolución de conflictos domésticos. 1800-1850, Valle Central de Chile

    Directory of Open Access Journals (Sweden)

    Valentina Bravo Olmedo

    2016-01-01

    Full Text Available El presente artículo tiene por objetivo analizar las prácticas de resolución de conflictos domésticos de las mujeres ante la justicia en los Partidos de Quillota, Aconcagua y Santiago entre 1800 y 1850, a través de la revisión de juicios civiles por pensión de alimentos entablados por mujeres casadas y solas. El periodo a analizar representa un proceso de legitimación de un régimen jurídico institucional. No obstante, las prácticas de resolución de conflictos estuvieron acompañadas de prácticas fronterizas, donde la ley y la costumbre estuvieron en permanente dialogo. En este contexto, proponemos que las mujeres recurrieron a la justicia institucional reclamando protección masculina para ellas y sus hijos, como parte de un sinfín de estrategias que se enmarcaban dentro de la justicia negociada, lo cual implicó, por parte de éstas, un desarrollo de estrategias que involucraron la resistencia de género, cultura jurídica y la publicidad del conflicto. De esto, distinguimos que las mujeres casadas, amparadas por la institución matrimonial, impulsaron estrategias apegadas a los ideales hegemónicos asegurando una pensión que correspondiera a sus necesidades. En cambio, las mujeres solas tuvieron que recurrir a estrategias más amplias y fronterizas que comprometía la solidaridad de sus cercanos, la divulgación del conflicto y  el honor femenino.

  19. Una mirada de los aspectos económicos, simbólicos y emocionales como parte de un conjunto de prácticas que determinan experiencias de consumo de bienes de lujo

    Directory of Open Access Journals (Sweden)

    Mauricio Edgardo Muñoz Osores

    2015-03-01

    Full Text Available El presente trabajo tiene por objeto, identificar y comprender las actitudes manifiestas por un grupo de consumidores de segmentos diferenciados, en relación al proceso de decisión de compra de marcas de lujo en dos regiones del país. A partir de sesiones de discusión en grupos y un posterior análisis cualitativo, se pretende obtener una conceptualización determinada sobre el significado de marca de lujo, los diferentes estados de bienestar o satisfacción generados por estas, así como también, la identificación de ciertas marcas que puedan clasificarse como de “lujo tradicional” y “nuevo lujo”. Este último punto es de gran relevancia para establecer y reconocer diferencias substanciales en el mercado del consumo de marcas de lujo, dado que por lo establecido en la presente investigación, el perfil o naturaleza de los compradores difiere, en términos de capacidad, frecuencia y motivos de compra. The present work aims to, identify and understand the manifest attitudes by a group of consumers of different segments, in relation to the decision-making process of purchase of brands of luxury in two regions of the country. From discussion groups and a subsequent qualitative analysis sessions, is expected to obtain a particular conceptualization about the meaning of luxury brand, different States of well-being or satisfaction generated by these, as well as the identification of certain brands that may be classified as “traditional luxury” and “new luxury”. This last point is of great importance to establish and recognize substantial di erences in the consumer market of luxury brands, given that by what is established in the present investigation, the pro le or nature of buyers differs, in terms of capacity, frequency and reasons for purchase.

  20. ¿Cuál es la contribución de la disfunción ejecutiva al perfil cognitivo del trastorno bipolar? Un estudio comparativo bien controlado

    OpenAIRE

    Lopera-Vasquez, Juan; Bell, Vaughan; López-Jaramillo, Carlos

    2011-01-01

    Background: Large scale neuropsychological studies of patients with bipolar disorder have reported verbal memory and executive function deficits that persist during remission. A recent analysis by Thompson et al. (2009) indicated that verbal memory deficits could be entirely explained by the statistical variance attributed to primary executive function deficits. This study tests the hypothesis that verbal memory deficits in bipolar patients are largely the result of executive difficulties by ...

  1. Formación bruta de capital en bienes de equipo en chile, 1856-1930: Fuentes nacionales y extranjeras Gross Capital Formation in Equipment in Chile, 1856-1930: National and Foreign Sources

    Directory of Open Access Journals (Sweden)

    Cristián Ducoing

    2013-04-01

    Full Text Available Pese a contar con unas de las mejores estadísticas de los países en desarrollo, existen lagunas en las series económicas de Chile, las cuales se han corregido a lo largo de los años. El trabajo conjunto de los autores ha permitido conocer las similitudes y diferencias entre una evaluación basada en las estadísticas chilenas y otra elaborada con las estadísticas del comercio exterior del G-3 (Alemania, Estados Unidos y Gran Bretaña. El objetivo del artículo es contrastar las series de inversión en maquinaria para Chile desde 1856 hasta 1930 y servir de base para otros estudios que quieran aportar nuevas series que permitan entender el desarrollo de Chile en el largo plazo.Despite having the best statistics in developing countries, there are a number of gaps in Chile's economic series, which have been being corrected over the years. Our joint work has allowed knowing the similarities and differences between series made from the Chilean statistical yearbooks and official trade statistics of G-3 (Germany, USA and Great Britain. The article aims to contrast both machinery investment series for Chile from 1856 to 1930 and provide a basis for other studies that want to make new series for understanding the development of Chile in the long term.

  2. L'impact de l'obsolescence perçue des biens durables sur la décision de remplacement et la destinée de l'objet remplacé

    OpenAIRE

    Guillard , Valérie; Le Nagard , Emmanuelle

    2018-01-01

    This research aims to understand, define and measure the perceived obsolescence of durable goods. A qualitative study of 10 people followed by three quantitative studies of 765 people made it possible to i) define the obsolescence of a durable good owned by a consumer as his/her perception that there is a better product on the market; (ii) to measure its technological, social, ecological, market and technological dimensions and (iii) to understand its antecedents and its consequence on the in...

  3. Agua: ¿patrimonio vital o bien económico? el problema de la privatización del agua en manaos, amazonía brasileña

    OpenAIRE

    Villa Fontecha, Germán Humberto

    2011-01-01

    La presente tesis busca reivindicar la importancia de la reflexión sobre la problemática global del agua, estableciendo como marco de referencia teórica, por un lado, la conceptualización propia de la Teoría de la Acción Racional (TAR) como modelo de comprensión de la acción humana propio de la ciencia económica y, por otro, algunas de las nociones más importantes de la reflexión biopolítica. Se trata de observar cómo el agua, un líquido absolutamente necesario para el origen y conservación d...

  4. Chances for the development of manufactures of capital goods. Analysis of the situation and sector evolution; Oportunidades para el desarrollo de los fabricantes de bienes de equipo. Analisis de la situacion y evolucion del sector

    Energy Technology Data Exchange (ETDEWEB)

    Pelaez Ramos, M. L.

    2012-07-01

    The main purpose of this paper is to analyze the situation and development in the capital goods sector in Spain. This industry is not just an important sector in the Spanish economy but, given its structural characteristics (dynamism, influence on the production processes of other activities and presence in all developed countries), it conditions the recovery of our economy. The article includes an analysis of the weaknesses, threats, strengths and opportunities of the sector. Further, it is crucial its contribution to make sustainable development of industrial activity. Also, it deals with those opportunities that are presented for the future development of this industry such as eco-design, energy efficiency and life cycle analysis. (Author)

  5. Editorial. Impact of the Binge Drinking (BD) in Adolescence. Are we doing it right? Editorial. Impacto del consumo episódico excesivo de alcohol en la adolescencia. ¿Lo estamos haciendo bien?

    Science.gov (United States)

    Vargas-Martínez, Ana Magdalena; Trapero-Bertran, Marta; Gil-García, Eugenia; Lima-Serrano, Marta

    2018-04-15

    Nowadays, one of the most prevalent patterns of alcohol consumption is called binge drinking (BD). In 2015, the European School Survey Project on Alcohol and Drugs (ESPAD) Group estimated that about 35% of adolescents of 15-16 years old have had at least one BD occasion in the past 30 days while at national level, the series of surveys on the use of drugs in adolescents of secondary education (ESTUDES, 2014-2015) determined that 32.2% of adolescents stated having performed BD in the last month. The aim of this editorial was to update the context of adolescence drinking and analysing the impact of BD by ages, including health and social costs derived. Once the magnitude of the problem was set, some research and action lines have been established in order to guide future work for the prevention of alcohol misuse and for establishing future preventive policies on alcohol. Finally, the need for evaluating these interventions from the efficiency point of view was discussed and assessed.

  6. La razonable valuación de los bienes de cambio en un marco de control interno e informatización de los procesos aplicada a la empresa constructora Electroingeniería S.A.

    OpenAIRE

    Ortiz, Jesica Anabela

    2016-01-01

    I. INTRODUCCIÓN -- II. METODOLOGÍA -- III. RESULTADOS Y DISCUSION -- A.- Estudio Exploratorio Bibliográfico sobre Auditoria Interna en el contexto de la empresa Electroingeniería S.A. -- 1. Definición de Auditoria Interna -- 2. Definición de Control Interno -- 3. Análisis de Inventarios en el marco del control interno -- B.- Estudio Exploratorio Bibliográfico sobre Auditoria de los Sistemas de Información -- Computarizados en el contexto de la empresa Electroingeniería S.A. -- 1. Auditoría I...

  7. The radiation linked to uranium natural radioactivity enlightened by Abel Niepce long time before Henri Becquerel;Les rayonnements lies a la radioactivite naturelle de l'uranium mis en evidence par Abel Niepce bien avant Henri Becquerel

    Energy Technology Data Exchange (ETDEWEB)

    Fournier, J.; Niepce, J.C.

    2009-09-15

    Abel Niepce was rarely mentioned during the celebration of the centenary of the radioactivity discovery.This discovery, supposed due to chance alone, is entirely attributed to Henri Becquerel. But Abel Niepce who made the first observation of radiation from uranium with the impression of a photographic plate, but without giving it meaning. This is a slow process which in forty years, from an observation misunderstood by Abel Niepce to its interpretation by Frederick Soddy, through the experiments of Henri Becquerel and thanks to developments in other knowledge (electron, X-rays) has led to a scientific progress known under the term of radioactivity, name given by Marie Slodowska-Curie. (N.C.)

  8. Influence of tungsten microstructure and ion flux on deuterium plasma-induced surface modifications and deuterium retention

    NARCIS (Netherlands)

    Buzi, L.; De Temmerman, G.; Unterberg, B.; M. Reinhart,; Dittmar, T.; Matveev, D.; Linsmeier, C.; Breuer, U.; Kreter, A.; Van Oost, G.

    2015-01-01

    The influence of surface temperature, particle flux density and material microstructure on the surface morphology and deuterium retention was studied by exposing tungsten targets (20&#xa0;μm and 40&#xa0;μm grain size) to deuterium plasma at the same particle fluence (1026&#xa0;m−2) and

  9. Cross System Extensions (CSE) experience

    International Nuclear Information System (INIS)

    Johnston, T.Y.

    1990-08-01

    Cross System Extension (CSE) provides VM/XA systems with the ability to share minidisks and spool in loosely coupled environment. CSE will also cooperate with the VM/HPO Inter System Facility (ISF) in sharing minidisks between VM/XA and VM/HPO to XA, reliability of CSE, and some operational considerations when running with it

  10. Nucleotide diversity analysis of three major bacterial blight resistance genes in rice.

    Directory of Open Access Journals (Sweden)

    Waikhom Bimolata

    Full Text Available Nucleotide sequence polymorphisms among R gene alleles influence the process of co-evolutionary interaction between host and pathogen by shaping the response of host plants towards invading pathogens. Here, we present the DNA sequence polymorphisms and diversities present among natural alleles of three rice bacterial blight resistance genes, Xa21, Xa26 and xa5. The diversity was examined across different wild relatives and cultivars of Oryza species. Functional significance of selected alleles was evaluated through semi-quantitative reverse transcription polymerase chain reaction and real time PCR. The greatest nucleotide diversity and singleton variable sites (SVS were present in Xa26 (π = 0.01958; SVS = 182 followed by xa5 and Xa21 alleles. The highest frequency of single nucleotide polymorphisms were observed in Xa21 alleles and least in xa5. Transition bias was observed in all the genes and 'G' to 'A' transitions were more favored than other form of transitions. Neutrality tests failed to show the presence of selection at these loci, though negative Tajima's D values indicate the presence of a rare form of polymorphisms. At the interspecies level, O. nivara exhibited more diversity than O. sativa. We have also identified two nearly identical resistant alleles of xa5 and two sequentially identical alleles of Xa21. The alleles of xa5 showed basal levels of expression while Xa21 alleles were functionally not expressed.

  11. Model-Based Illumination Correction for Face Images in Uncontrolled Scenarios

    NARCIS (Netherlands)

    Boom, B.J.; Spreeuwers, Lieuwe Jan; Veldhuis, Raymond N.J.

    2009-01-01

    Face Recognition under uncontrolled illumination conditions is partly an unsolved problem. Several illumination correction methods have been proposed, but these are usually tested on illumination conditions created in a laboratory. Our focus is more on uncontrolled conditions. We use the Phong model

  12. NSR superstring measures revisited

    International Nuclear Information System (INIS)

    Morozov, A.

    2008-01-01

    Review of remarkable progress in evaluation of NSR superstring measures, originated by E.D'Hoker and D.Phong. These recent results are presented in the old-fashioned form, what allows to highlight the options which have been overlooked in original considerations in late 1980's.

  13. The Effects of Communicative Grammar Teaching on Students' Achievement of Grammatical Knowledge and Oral Production

    Science.gov (United States)

    Ho, Pham Vu Phi; The Binh, Nguyen

    2014-01-01

    So far the students of Le Hong Phong Junior High School have been taught grammar with GTM (Grammar-Translation Method), which just prepares learners for conventional grammar-paper tests. Despite their considerable knowledge of grammar, the students fail to use the language they have learnt to communicate in real-life situations. The purpose of…

  14. Thailand: gas import review takes on urgency

    International Nuclear Information System (INIS)

    Hayes, D.

    1992-01-01

    The potential market for natural gas imports in Thailand as a result of the downgrading of gas reserves in the Nan Phong field is examined. Proposed pipelines, plans for gas-fired power plants, and the effects that the downgrading has had on Thailand's long-term plans for the development of gas utilisation are discussed. (UK)

  15. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. N D Sang1 P H Quang2 L T Tu2 D T B Hop2. National University of Civil Engineering, 55 Giai Phong Street, Hai Ba Trung, Hanoi, Vietnam; Hanoi University of Science, Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam ...

  16. Extreme Apprenticeship – Emphasising conceptual understanding in undergraduate mathematics

    OpenAIRE

    Rämö , Johanna; Oinonen , Lotta; Vikberg , Thomas

    2015-01-01

    International audience; Extreme Apprenticeship (XA) is an educational method that has been used in teaching undergraduate mathematics in the University of Helsinki. In this paper, we analyse the course assignments and exam questions of a certain lecture course that has recently been reformed to an XA-based course. The results show that the XA method has made it possible to move the emphasis from rote learning towards understanding the concepts behind the procedures.

  17. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from LPS-stimulated myeloid cells.

    LENUS (Irish Health Repository)

    Gleeson, Eimear M

    2013-07-19

    Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease crucial for blood coagulation, also induces protease-activated receptor-dependent cell signaling. Factor Xa can bind both monocytes and macrophages, but whether factor Xa-dependent signaling stimulates or suppresses myeloid cell cytokine production in response to Toll-like receptor activation is not known. In this study, exposure to factor Xa significantly impaired pro-inflammatory cytokine production from lipopolysaccharide-treated peripheral blood mononuclear cells, THP-1 monocytic cells and murine macrophages. Furthermore, factor Xa inhibited nuclear factor-kappa B activation in THP-1 reporter cells, requiring phosphatidylinositide 3-kinase activity for its anti-inflammatory effect. Active-site blockade, γ-carboxyglutamic acid domain truncation and a peptide mimic of the factor Xa inter-epidermal growth factor-like region prevented factor Xa inhibition of lipopolysaccharide-induced tumour necrosis factor-α release. In addition, factor Xa anti-inflammatory activity was markedly attenuated by the presence of an antagonist of protease-activated receptor 2, but not protease-activated receptor 1. The key role of protease-activated receptor 2 in eliciting factor Xa-dependent anti-inflammatory signaling on macrophages was further underscored by the inability of factor Xa to mediate inhibition of tumour necrosis factor-α and interleukin-6 release from murine bone marrow-derived protease-activated receptor 2-deficient macrophages. We also show for the first time that, in addition to protease-activated receptor 2, factor Xa requires a receptor-associated protein-sensitive low-density lipoprotein receptor to inhibit lipopolysaccharide-induced cytokine production. Collectively, this study supports a novel function for factor Xa as an endogenous, receptor

  18. Cytological diagnosis of xanthogranulomatous appendicitis

    Directory of Open Access Journals (Sweden)

    Rajni Kaushik

    2017-01-01

    Full Text Available Xanthogranulomatous reaction can occur in any organ but the most common sites are kidney and gallbladder. Xanthogranulomatous appendicitis (XA is a rare clinical entity. There are a few case reports of XA diagnosed on histopathology but none on cytology. Here we report a case of a 47-year-old lady who presented with acute abdomen and was found to have a mass lesion in the right iliac fossa. She was diagnosed with XA intraoperatively on imprint cytology that was subsequently confirmed on histopathological examination. Due to the rarity of XA itself and the use of imprint cytology for intraoperative diagnosis the case is being presented.

  19. Functional Marker Assisted Improvement of Stable Cytoplasmic Male Sterile Lines of Rice for Bacterial Blight Resistance

    Directory of Open Access Journals (Sweden)

    Jegadeesan Ramalingam

    2017-06-01

    Full Text Available Bacterial blight (BB, caused by Xanthomonas oryzae pv.oryzae is one among the major diseases in rice, which in severe condition cause losses up to 60% in total yield. Marker assisted pyramiding of three broad spectrum BB resistance genes (xa5, xa13, and Xa21 in prominent rice varieties is the most economical and effective strategy for the management of the BB disease. We report here the pyramiding of three genes (xa5, xa13, and Xa21 in maintainer lines (CO 2B, CO 23B, and CO 24B of three promising wild abortive cytoplasmic male sterile lines (CO 2A, CO 23A, and CO 24A through functional markers assisted back cross breeding. IRBB60 with xa5, xa13, and Xa21 genes is used as a donor parent. BC2F1 and BC2F2 generations from a cross of CO 2B, CO 23B, and CO 24B with IRBB60 were evaluated for bacterial blight and non-fertility restoration. In BC2F1, plants with all three resistance genes (xa5, xa13, and Xa21 and high parent genome recovery was identified. In BC2F2, plants with all resistance genes and without fertility restorer (Rf3 and Rf4 were selected. Based on agronomic traits, BB resistance and maintenance of sterility, two plants each in CO 2B × IRBB60, CO 24B × IRBB60 and one plant in CO 23B × IRBB60 combinations were identified. The identified lines were crossed with respective male sterile lines for conversion of improved B line into CMS line through back-crossing, in addition to selfing. The plants with high recurrent genome and phenotypically similar to parental lines and sterile are being used for the hybrid rice development program. Currently, using these lines (improved CMS line, test crosses were made to develop new rice hybrids. Hybrids combinations viz., CO 23A × AD08009R and CO 24A × IET20898R were found to be stable at different locations with high yield. The R line used in this study has been introgressed with xa5, xa13, and Xa21 genes in a separate breeding program. These new hybrids with resistance against bacterial blight

  20. The effects of blood feeding and exogenous supply of tryptophan on the quantities of xanthurenic acid in the salivary glands of Anopheles stephensi (Diptera: Culicidae).

    Science.gov (United States)

    Okech, Bernard; Arai, Meiji; Matsuoka, Hiroyuki

    2006-03-24

    Xanthurenic acid (XA), produced as a byproduct during the biosynthesis of insect eye pigment (ommochromes), is a strong inducer of Plasmodium gametogenesis at very low concentrations. In previous studies, it was shown that XA is present in Anopheles stephensi (Diptera: Culicidae) mosquito salivary glands and that during blood feeding the mosquitoes ingested their own saliva into the midgut. Considering these two facts together, it is therefore likely that XA is discharged with saliva during blood feeding and is swallowed into the midgut where it exerts its effect on Plasmodium gametocytes. However, the quantities of XA in the salivary glands and midgut are unknown. In this study, we used high performance liquid chromatography with electrochemical detection to detect and quantify XA in the salivary glands and midgut. Based on the results of this study, we found 0.28+/-0.05 ng of XA in the salivary glands of the mosquitoes, accounting for 10% of the total XA content in the mosquito whole body. The amounts of XA in the salivary glands reduced to 0.13+/-0.06 ng after mosquitoes ingested a blood meal. Approximately 0.05+/-0.01 ng of XA was detected in the midgut of nonblood fed An. stephensi mosquitoes. By adding synthetic tryptophan as a source of XA into larval rearing water (2 mM) or in sugar meals (10 mM), we evaluated whether XA levels in the mosquito (salivary glands, midgut, and whole body) were boosted and the subsequent effect on infectivity of Plasmodium berghei in the treated mosquito groups. A female specific increase in XA content was observed in the whole body and in the midgut of mosquito groups where tryptophan was added either in the larval water or sugar meals. However, XA in the salivary glands was not affected by tryptophan addition to larval water, and surprisingly it reduced when tryptophan was added to sugar meals. The P. berghei oocyst loads in the mosquito midguts were lower in mosquitoes fed tryptophan treated sugar meals than in mosquitoes

  1. Prolonged Cerebral Circulation Time Is the Best Parameter for Predicting Vasospasm during Initial CT Perfusion in Subarachnoid Hemorrhagic Patients.

    Directory of Open Access Journals (Sweden)

    Chun Fu Lin

    Full Text Available We sought to imitate angiographic cerebral circulation time (CCT and create a similar index from baseline CT perfusion (CTP to better predict vasospasm in patients with subarachnoid hemorrhage (SAH.Forty-one SAH patients with available DSA and CTP were retrospectively included. The vasospasm group was comprised of patients with deterioration in conscious functioning and newly developed luminal narrowing; remaining cases were classified as the control group. The angiography CCT (XA-CCT was defined as the difference in TTP (time to peak between the selected arterial ROIs and the superior sagittal sinus (SSS. Four arterial ROIs were selected to generate four corresponding XA-CCTs: the right and left anterior cerebral arteries (XA-CCTRA2 and XA-CCTLA2 and right- and left-middle cerebral arteries (XA-CCTRM2 and XA-CCTLM2. The CCTs from CTP (CT-CCT were defined as the differences in TTP from the corresponding arterial ROIs and the SSS. Correlations of the different CCTs were calculated and diagnostic accuracy in predicting vasospasm was evaluated.Intra-class correlations ranged from 0.96 to 0.98. The correlations of XA-CCTRA2, XA-CCTRM2, XA-CCTLA2, and XA-CCTLM2 with the corresponding CT-CCTs were 0.64, 0.65, 0.53, and 0.68, respectively. All CCTs were significantly prolonged in the vasospasm group (5.8-6.4 s except for XA-CCTLA2. CT-CCTA2 of 5.62 was the optimal cut-off value for detecting vasospasm with a sensitivity of 84.2% and specificity 82.4.CT-CCTs can be used to interpret cerebral flow without deconvolution algorithms, and outperform both MTT and TTP in predicting vasospasm risk. This finding may help facilitate management of patients with SAH.

  2. De olhos bem abertos: investigando acuidade visual em alunos de uma escola municipal de Vitória De ojos bien abiertos: investigar la agudeza visual de los alumnos de una escuela municipal en la ciudad de Vitória With opened eyes: evaluating the visual acuity of children at an elementary school in Vitória

    Directory of Open Access Journals (Sweden)

    Mariana Rabello Laignier

    2010-03-01

    Full Text Available Esta pesquisa buscou verificar a acuidade visual dos estudantes de uma escola municipal de Vitória Espírito Santo, por meio da aplicação do teste de acuidade visual, baseado na Escala de Snellen; e encaminhar, para exame especializado no ambulatório de oftalmologia do Hospital Universitário Cassiano Antônio Moraes, as crianças que apresentaram déficit visual. Foi um estudo de abordagem quantitativa que discutiu a acuidade visual relacionada ao sexo, idade, série, uso de lentes corretoras e diagnóstico médico. Das 168 crianças avaliadas, maior número de meninas apresentou baixa acuidade visual, assim como os alunos mais jovens; o uso de lentes predominou naqueles que apresentaram redução da acuidade visual; e 71,4% das crianças encaminhadas ao médico apresentaram algum grau de ametropia. Concluiu-se que o trabalho de prevenção é fundamental para se obter uma ótima saúde visual, e que o profissional de saúde é fundamental no desenvolvimento de projetos voltados para a saúde escolar.Este estudio analiza la agudeza visual de los niños de una escuela municipal en la ciudad de Vitória Espírito Santo, mediante la aplicación de la prueba de agudeza visual. Basado en la escala de Snellen; y remitir para un examen especializado en la clínica de oftalmología del Hospital Universitario Cassiano Antônio Moraes a los niños con trastornos visuales. Desarrolla un estudio de enfoque cuantitativo y se analiza la agudeza visual relacionada con el género, la edad, la serie, el uso de lentes correctoras y el diagnóstico médico. De los 168 niños evaluados, mayor cantidad de las niñas exhibirán baja agudeza visual, así como los grupos de edad más jóvenes; el uso de lentes prevalece sobre las personas con reducción de la agudeza visual; y 71,4% de los niños a que se refiere el médico había cierto grado de ametropia. Se concluyó que el trabajo de la prevención es fundamental para obtener una óptima salud visual, y que el profesional de la salud es esencial en el desarrollo de proyectos destinados a la salud escolar.This research evaluates the visual acuity of children at Prezideu Amorim Elementary School in the city of Vitória Espírito Santo, based on applying the scale of Snellen; and children who had visual disorders were referred to specialist examination at the ophthalmology clinic of Antônio Cassiano Moraes University Hospital. This essay develops a study of quantitative approach and discussed visual acuity related to sex, age, grade, use of corrective lenses and medical diagnosis. The results showed that the girls present greater prevalence of low visual acuity, as well as the younger age ranks; the use of lenses prevails on those that presented reduction of the visual acuity; and the majority of the children sent to the doctor presented some degree of ametropy. It concluded that prevention in order to get an excellent visual health is a duty of the health professional and of the professor, that together, they can develop other projects in the field of school health.

  3. Usage des TIC, qualité de vie, bien-être et santé psychologique au travail: une étude réalisée au ministère de l'économie numérique, de la communication et de la poste au Gabon

    OpenAIRE

    Medzo-M 'engone , Joseph

    2017-01-01

    The use of technology in public organizations in some African countries such as Gabon reflects a desire to improve quality of service for users and to make work processes more effective. Literature presents evidences that technological innovations in Western companies bring some advantages on both organizational and socio-professional levels, but also numerous negative impacts. The impact of technological change on occupational and organizational psychology in Public Administration in Gabon h...

  4. Por el bien de la economía nacional: trabajo terapéutico y asistencia pública en el Manicomio de La Castañeda de la ciudad de México, 1929-1932 For the good of the nation's economy: therapeutic work and public assistance at La Castañeda asylum in Mexico City, 1929-32

    Directory of Open Access Journals (Sweden)

    Cristina Sacristán

    2005-12-01

    Full Text Available El Manicomio de La Castañeda de la Ciudad de México, fundado en 1910, enfrentó hacia 1930 el problema de su masificación debido al elevado número de pacientes crónicos que hacían ver a la institución como un depósito de enfermos más que como un espacio terapéutico. Esta circunstancia condujo a la psiquiatría a su primera crisis de legitimidad como ciencia. Con el objetivo de combatir la leyenda negra en torno al manicomio, los médicos de La Castañeda promovieron la difusión en la prensa de un tratamiento de origen decimonónico que proyectaba la imagen pública de que los enfermos mentales podían tener la misma capacidad productiva que el resto de los hombres: la terapéutica por medio del trabajo. Esta propuesta contó con el apoyo del Estado emanado de la revolución mexicana porque el objetivo que guiaba la asistencia pública a los grupos más desprotegidos consistía en lograr su integración a la vida productiva del país a través del mercado, lo que se obtenía en el caso de los enfermos mentales a través de la terapia ocupacional.Founded in 1910, by 1930 Mexico City's La Castañeda insane asylum was grappling with the problem of a massive number of chronic patients, a situation that earned it an image as a warehouse for the sick more than a place of treatment. Psychiatrists endeavored to restore the asylum's legitimacy by publicizing a nineteenth-century treatment which projected the public image that the mentally ill could be as productive as anyone else: work therapy. The government born of the Mexican revolution supported this proposal because the guiding objective behind public assistance for underprivileged groups was to make them part of the country's productive life via the market.

  5. ¿Qué tan bien representados están los mamíferos mexicanos en la red federal de áreas naturales protegidas del país? How well represented are Mexican mammals in the natural protected area network?

    Directory of Open Access Journals (Sweden)

    Luis-Bernardo Vázquez

    2009-04-01

    Full Text Available Se evaluaron la eficiencia y eficacia de la red de áreas naturales protegidas (ANPs federales de México para representar la riqueza de especies de mamíferos terrestres. Para determinar el porcentaje de especies no protegidas, se sobrepuso una gradilla de celdas de 0.5° x 0.5° con datos de riqueza de especies en el mapa de las ANPs y se comparó con conjuntos equivalentes de áreas seleccionados al azar. Mediante optimización se estimó cuántas celdas adicionales complementarían a las ANPs y cuántas áreas bastarían para proteger todas las especies al menos una vez. Los resultados indican que cerca de la quinta parte del total de especies, un tercio de las endémicas y un tercio de las vulnerables, no están protegidas. En conjuntos de celdas elegidos al azar se representan más especies que en el total de celdas cubiertas por ANPs. En la península de Baja California, la vertiente del Pacífico, la sierra Madre Occidental y el sur del país (Oaxaca se concentra el mayor número de especies no protegidas. Para complementar las celdas con ANPs se requieren 25 celdas adicionales y bastarían conjuntos óptimos de 38 celdas para representar todas las especies al menos una vez. Nuestros resultados pueden ayudar a mejorar la selección de nuevas ANPs para ganar en eficacia y eficiencia al representar a las especies de mamíferos aún no protegidas.We evaluated the efficacy and efficiency of the federal network of natural protected areas (NPAs to represent the species richness of terrestrial mammals. We overlapped a 0.5° x 0.5° grid with data on species richness with the map of NPAs, to determine the proportion of unprotected species. We compared this with equivalent sets of cells, chosen randomly. In addition, through optimization we determined how many additional cells will complement the NPAs and how many cells will represent all species at least once. We found that nearly 1/5 of the total species, 1/3 of the endemics and 1/3 of the threatened species are unprotected. The sets of cells randomly chosen represent more species than the totality of grid cells with NPAs studied. The Baja California Peninsula, Pacific Slope, the Sierra Madre Occidental, and the south of the country (Oaxaca concentrate the highest number of unprotected species. We found that to complement the grid cells with NPAs 25 additional cells are needed and that a set of 38 cells chosen optimally will be enough to represent all species at least one time. Our results can help to improve the selection of new NPAs to gain in efficacy and efficiency in the representation of still unprotected species.

  6. Qualidade de vida e bem-estar espiritual em pacientes com doença pulmonar obstrutiva crônica Calidad de vida y bien estar espiritual en pacientes con enfermedad pulmonar obstructiva crónica Quality of life and spiritual well-being in chronic obstructive pulmonary disease patients

    Directory of Open Access Journals (Sweden)

    Maíra Shiramizu da Silva

    2009-12-01

    Full Text Available Este estudo teve como objetivos avaliar a qualidade de vida relacionada à saúde (QVRS e o bem-estar espiritual (BEE de pacientes com doença pulmonar obstrutiva crônica (DPOC e analisar as relações entre QVRS e BEE. As versões em português do Seattle Obstructive Lung Disease Questionnaire (SOLDQ e do Spiritual Well-Being Scale (SWBS foram aplicadas por entrevista a 70 pacientes com DPOC em tratamento ambulatorial. Os domínios do SOLDQ com menor e maior escores foram: Função Física (37,29±17,19 e Satisfação com o Tratamento (68,75±28,05. O escore médio de 94,87±13,56 indica um nível moderado de BEE. O escore total do SWBS e o da subescala Bem-Estar Religioso correlacionaram-se positivamente com o domínio Satisfação com o Tratamento (p=0,007 e p=0,002, respectivamente. Correlação negativa foi encontrada entre Bem-Estar Religioso e Função Física (p=0,05. Pacientes com maior bem-estar religioso estavam mais satisfeitos com o tratamento e tinham pior funcionamento físico.En este estudio se evaluaron la calidad de vida relacionada con la salud (CVRS y el bienestar espiritual (BEE de pacientes con enfermedad pulmonar obstructiva crónica (EPOC y además la relación entre la CVRS y BEE. Setenta pacientes con EPOC en tratamiento ambulatorial fuerón entrevistados usando las versiones en portugués del Seattle Obstructive Lung Disease Questionnaire (SOLDQ y del Spiritual Well-Being Scale (SWBS. Las dimensiones del SOLDQ con puntuaciones más bajos y más altos fueron: Función Física (37,29 ± 17,19 y Satisfacción con el Tratamiento (68,75 ± 28,05. La puntuación media 94,87 ± 13,56 indica un nivel moderado de BEE. La puntuación total del Bienestar Religioso correlacionó positivamente con la Satisfacción con el Tratamiento (p = 0,007 y p = 0,002, respectivamente. Se encontró correlación negativa entre bienestar religioso y función físico (p = 0,05. Los pacientes con mayor bienestar religioso estaban más satisfechos con el tratamiento y tenían peor función físico.This study aimed to evaluate health related quality of life (HRQL and spiritual well-being (SWB of patients with chronic obstructive pulmonary disease (COPD and to investigate the relationship between HRQOL and SWB. Seventy outpatients with COPD were interviewed using Portuguese versions of the Seattle Obstructive Lung Disease Questionnaire (SOLDQ and Spiritual Well-Being Scale (SWBS. SOLDQ domains with lowest and highest scores were Physical Function (37.29±17.19 and Treatment Satisfaction (68.75±28.05. Total score of the SWBS was 94.87±13.56, indicating a moderate level of SWB. Total SWB and the subscale Religious Well-Being correlate positively with Treatment Satisfaction (p=0.007 and p=0.002, respectively. Negative correlation were found between Religious Well-Being and Physical Function domain (r = -0.233, p=0.05. Patients with higher spiritual/religious well-being were more satisfied with treatment and had worst physical functioning.

  7. "Allo Berkeley ? Ici Lyon… Vous nous voyez bien ?" Étude d'un dispositif de formation en ligne synchrone franco-américain à travers les discours de ses usagers Study of a synchronous online language learning programme: the impact of videoconferencing and synchronicity on learners and tutor trainees

    Directory of Open Access Journals (Sweden)

    Richard Kern

    2008-12-01

    Full Text Available Cet article se donne comme objectif d'étudier l'impact de la multimodalité et de la synchronie sur la communication pédagogique en ligne à travers le discours des usagers d'une formation en ligne synchrone. Celle-ci s'est déroulée en 2007 et, dans le cadre d'un dispositif d'enseignement / apprentissage en ligne synchrone, a mis en relation des dyades d'étudiants de master professionnel de l'université de Lyon 2 et des dyades d'étudiants de français de l'université de Californie de Berkeley via une plateforme de visioconférence poste à poste. Après avoir présenté le dispositif pédagogique, nous chercherons, à partir d'entretiens effectués auprès des deux catégories de participants (apprentis tuteurs et apprenants, à rendre compte de l'empan des représentations associées à une même pratique d'un dispositif d'enseignement / apprentissage en ligne : les types d'utilisation des modalités (écrit, oral, visuel par les participants, les effets psycho-affectifs liés à une situation d'échange multimodal synchrone et, enfin, les compétences développées dans ce dispositif. L'analyse des deux corpus (français et américain montre une appropriation progressive de la communication à travers ce dispositif par les usagers, ainsi que le développement de compétences spécifiques : du côté des apprenants américains, une amélioration au niveau de l'aisance dans la prise de parole, du côté des apprentis tuteurs français une appropriation de gestes professionnels liés à l'écoute et à la spontanéité dans la relation pédagogique.This article studies the impact of multimodality and synchronicity on an online teaching/learning exchange between dyads of Masters degree students in teaching French as a foreign language at the University of Lyon 2 and dyads of intermediate-level French students at the University of California, Berkeley during the 2006-07 academic year. The desktop videoconferencing platform allowed face-to-face audiovisual communication as well as synchronous written chat. Based on observational and interview data, the study explores how participants use speech, writing, and visual contact online, the affective effects of these uses, and the types of competences developed as a consequence. Analysis of the two corpora (French and American shows a progressive adaptation to the particularities of desktop videoconferencing and the development of specific competencies: among the American learners of French, greater confidence and ease in taking the floor; among the French teachers-in-training, development of a professional online persona and flexibility in their pedagogical stance and strategies.

  8. La qualité bien rare de Sâlih Ibn Yahyâ parmi les historiens orientaux au Moyen Âge: Écrire l'histoire des émirs Buhtur en utilisant les archives familiales

    Directory of Open Access Journals (Sweden)

    Pierre Moukarzel

    2012-01-01

    Full Text Available Sâlih Ibn Yahyâ, à la différence des chroniqueurs du xive et du xve siècle, a consacré son œuvre à écrire l’histoire de sa famille. Cet ouvrage est très important car il est fondé dans sa plus grande partie sur des archives familiales conservées par les émirs Buhtur qui ont régné sur une région du Mont Liban appelée al-Gharb.Ces archives comprennent des pièces officielles, des lettres patentes, des acts d’iqṭâ‛, des décrets, des ordres, que les émirs Buhtur ont reçus, soit de la cour d’Égypte, soit de celle de Damas, soit encore des Mongols ou des Francs.Ces pièces d’archives couvrent une période allant du xiie jusqu’au xive siècle. Leur présentation et leur analyse fournissent des informations très intéressantes sur l’usage et les règles de la rédaction dans les chancelleries des sultans zinghîdes, ayyûbîdes et des premiers sultans mamelouks.

  9. Abstracts and electronic proceedings of the Canadian Dam Association's 2009 annual conference : protecting people, property and the environment; Resumes et actes electroniques du congres annuel 2009 de l'Association canadienne des barrages : proteger les personnes, les biens et l'environnement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    The Canadian Dam Association (CDA) is the Canadian leader in advancing knowledge and practices related to dams. This annual conference provided a professional development opportunity on a broad range of dam-related topics. The technical sessions addressed issues such as adaptation to climate change; the application of safety design for discharge facilities; risks associated with rockfill dams; underlying problems of design floods and dam safety; guidelines for public safety around dams and psychology of safety; the dam safety review process; and run-of-river hydro dams. During the related sessions, Canadian members of the International Committee on Large Dams (ICOLD) commented on international practice and developments. The workshops focused on incident investigations; reliability-centered maintenance; flow discharge gate reliability; piping damage to till core dams; and mining dams. The sessions of the conference were entitled: design floods and dam safety; dam breach flood modelling; dam safety management; public safety; mining dams; flood handling and modelling; case studies; ice loads on structures; seepage control; dam safety reviews and remediation; remote sensing for dams; protecting the environment; seismic hazard and response modelling; and the performance of dams in 2008 earthquake in Sichuan, China. The conference featured 61 presentations, of which 59 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  10. Centralización o descentralización; gestión pública o privada de un “bien escaso”: historiografía sobre el agua en la ciudad de México en los siglos XIX y XX

    Directory of Open Access Journals (Sweden)

    Simón Ruiz, Inmaculada

    2007-12-01

    Full Text Available Essay about the management of the water in Mexico City during XIX and XX centuries. It reviews the most significant titles from the Porfiriato to our days with special interest in the most recent bibliography in the discussion around the paper that must have the State and the local governments in the control of the water. It treats to respond to the question if the water must be considered like merchandise or a human right, using the arguments of the defenders of one and the other idea.

    Ensayo historiográfico en torno a la gestión del agua en la ciudad de México en los siglos XIX y XX. Se revisan los títulos más significativos desde el Porfiriato a nuestros días, con especial interés en la bibliografía más reciente centrada en la discusión en torno al papel que deben tener el Estado y los gobiernos locales en el control y organización de la distribución de ese líquido tan necesario. Se trata de responder a la pregunta de si el agua debe ser considerada como mercancía o como derecho, utilizando los argumentos de los defensores de una y otra idea.

  11. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement

    DEFF Research Database (Denmark)

    Lassen, Michael Rud; Gallus, Alexander; Raskob, Gary E

    2010-01-01

    There are various regimens for thromboprophylaxis after hip replacement. Low-molecular-weight heparins such as enoxaparin predominantly inhibit factor Xa but also inhibit thrombin to some degree. Orally active, specific factor Xa inhibitors such as apixaban may provide effective thromboprophylaxis...

  12. Simultaneous and Sequential Feature Negative Discriminations: Elemental Learning and Occasion Setting in Human Pavlovian Conditioning

    Science.gov (United States)

    Baeyens, Frank; Vervliet, Bram; Vansteenwegen, Debora; Beckers, Tom; Hermans, Dirk; Eelen, Paul

    2004-01-01

    Using a conditioned suppression task, we investigated simultaneous (XA-/A+) vs. sequential (X [right arrow] A-/A+) Feature Negative (FN) discrimination learning in humans. We expected the simultaneous discrimination to result in X (or alternatively the XA configuration) becoming an inhibitor acting directly on the US, and the sequential…

  13. Helium effects on tungsten surface morphology and deuterium retention

    NARCIS (Netherlands)

    Ueda, Y.; H. Y. Peng,; H. T. Lee,; N. Ohno,; S. Kajita,; Yoshida, N.; Doerner, R.; De Temmerman, G.; V. Alimov,; G. Wright,

    2013-01-01

    Recent experimental results on tungsten surface morphology, especially nano-structure (fuzz), induced by helium plasma exposure at temperatures between 1000&#xa0;K and 2000&#xa0;K are reviewed. This structure was firstly reported in 2006. In this review, most of experimental results reported

  14. The impact of founder events on chromosomal variability in multiply mating species

    DEFF Research Database (Denmark)

    Pool, John E; Nielsen, Rasmus

    2008-01-01

    size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than...

  15. Xanthium italicum, Xanthium strumarium and Arctium lappa as new hosts for Diaporthe helianthi.

    Science.gov (United States)

    Vrandecic, Karolina; Jurkovic, Drazenka; Riccioni, Luca; Cosic, Jasenka; Duvnjak, Tomislav

    2010-07-01

    Sunflower (Helianthus annuus) stem canker caused by Diaporthe helianthi is one of the most important sunflower diseases in Croatia. Until recently, sunflower was the only known host for D. helianthi. In our research carried out in the area of Eastern Croatia, isolates of Diaporthe/Phomospis were collected from Xanthium italicum, X. strumarium and Arctium lappa. Using morphological, cultural and molecular ITS rDNA data, isolates from these weeds were identified as D. helianthi. The following isolates were used in the pathogenicity test: one isolate originated from sunflower (Su5/04), three from X. italicum (Xa2, Xa3 and Xa5), two from X. strumarium (Xa9 and Xa12), one from Xanthium sp. (Xa13) and one from A. lappa (Ar3). According to the results, it was determined that isolate Xa5 (originated from X. italicum) was the most pathogenic to sunflower stems. The average length of the lesion was 11.3 cm. The lowest level of pathogenicity was found in Xa9 (isolated from X. strumarium). The length of the lesion was 0.1 cm.

  16. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... backcross derived line possessing Xa21 + Pi2 and another possessing Xa33 were intercrossed to stack the target resistance genes into the genetic background of RPHR-1005. At ICF4, 10 promising lines possessing three resistance genes in homozygous condition along with fine-grain type, complete fertility restoration, ...

  17. African Journal of Biotechnology - Vol 11, No 33 (2012)

    African Journals Online (AJOL)

    Introgression of bacterial blight (BB) resistance genes Xa7 and Xa21 into popular restorer line and their hybrids by molecular marker-assisted backcross (MABC) selection scheme ... Concentration of selected heavy metals in water of the Juru River, Penang, Malaysia · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  18. Strategy Of Attrition: Why General Westmoreland Failed In 1967

    Science.gov (United States)

    2016-05-26

    assault on South Vietnamese regulars at Xa Tan Hung resulted in...with forty-six wounded. To complicate the situation, civilian casualties continued to mass. During the attack at Xa Tan Hung, the Viet Cong wounded...Ronald H. Advice And Support: The Early. Years, 1941-1960. Washington, DC: Center of Military History,1985. Taleb, Nassim Nicholas . Antifragile: Things

  19. Rivaroxaban in patients with a recent acute coronary syndrome

    DEFF Research Database (Denmark)

    Mega, Jessica L; Braunwald, Eugene; Wiviott, Stephen D

    2012-01-01

    Acute coronary syndromes arise from coronary atherosclerosis with superimposed thrombosis. Since factor Xa plays a central role in thrombosis, the inhibition of factor Xa with low-dose rivaroxaban might improve cardiovascular outcomes in patients with a recent acute coronary syndrome....

  20. Malaria infectivity of xanthurenic acid-deficient anopheline mosquitoes produced by TALEN-mediated targeted mutagenesis.

    Science.gov (United States)

    Yamamoto, Daisuke S; Sumitani, Megumi; Hatakeyama, Masatsugu; Matsuoka, Hiroyuki

    2018-02-01

    Anopheline mosquitoes are major vectors of malaria parasites. When the gametocytes of the malaria parasite are transferred from a vertebrate to mosquitoes, they differentiate into gametes, and are fertilized in the midguts of mosquitoes. Xanthurenic acid (XA), a waste product of the ommochrome synthesis pathway, has been shown to induce exflagellation during microgametogenesis in vitro; however, it currently remains unclear whether endogenous XA affects the infectivity of anopheline mosquitoes to malaria parasites in vivo due to the lack of appropriate experimental systems such as a XA-deficient line. In the present study, we produced a XA-deficient line in Anopheles stephensi using transcription activator-like effector nuclease (TALEN)-mediated gene targeting (knockout) of the kynurenine 3-monooxygenase (kmo) gene, which encodes an enzyme that participates in the ommochrome synthesis pathway. The knockout of kmo resulted in the absence of XA, and oocyst formation was inhibited in the midguts of these XA-deficient mosquitoes, which, in turn, reduced sporozoite numbers in their salivary glands. These results suggest that endogenous XA stimulates exflagellation, and enhances the infectivity of anopheline mosquitoes to malaria parasites in vivo. The XA-deficient line of the anopheline mosquito provides a useful system for analyzing and understanding the associated factors of malaria gametogenesis in the mosquito midgut.

  1. Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

    Directory of Open Access Journals (Sweden)

    Carmine Vecchione

    2017-05-01

    Full Text Available The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative role in the pathophysiology of inflammation-induced hypotension. Here, we show that xanthurenic acid (XA, the transamination product of 3-hydroxykynurenine, is more efficacious than L-kynurenine in causing relaxation of a resistance artery, but fails to relax pre-contracted aortic rings. In the mesenteric artery, XA enhanced activating phosphorylation of endothelial nitric oxide synthase (NOS, and the relaxing action of XA was abrogated by pharmacological inhibition of NOS and endothelial-derived hyperpolarizing factor. Systemic injection of XA reduced blood pressure in mice, and serum levels of XA increased by several fold in response to a pulse with the endotoxin, lipopolysaccharide (LPS. LPS-induced hypotension in mice was prevented by pre-treatment with the kynurenine monooxygenase (KMO inhibitor, Ro-618048, which lowered serum levels of XA but enhanced serum levels of L-kynurenine. UPF 648, another KMO inhibitor, could also abrogate LPS-induced hypotension. Our data identify XA as a novel vasoactive compound and suggest that formation of XA is a key event in the pathophysiology of inflammation-induced hypotension.

  2. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice

    Institute of Scientific and Technical Information of China (English)

    Jiao Wu; Haichuan Yu; Haofu Dai; Wenli Mei; Xin Huang; Shuifang Zhu; Ming Peng

    2012-01-01

    The metabolic changes of bacterial blight-resistant line C418/Xa23 generated by molecular marker-assisted selection (n =12),transgenic variety C418-Xa21 generated by using the Agrobacterium-mediated system (n =12),and progenitor cultivar C418 (n =12) were monitored using gas chromatography/mass spectrometry.The validation,discrimination,and establishment of correlative relationships between metabolite signals were performed by cluster analysis,principal component analysis,and partial least squares-discriminant analysis.Significant and unintended changes were observed in 154 components in C418/Xa23 and 48 components in C418-Xa21 compared with C418 (P < 0.05,Fold change > 2.0).The most significant decreases detected (P< 0.001) in both C418/Xa23 and C418-Xa21 were in three amino acids: glycine,tyrosine,and alanine,and four identified metabolites: malic acid,ferulic acid,succinic acid,and glycerol.Linoleic acid was increased specifically in C418/Xa23 which was derived from traditional breeding.This line,possessing a distinctive metabolite profile as a positive control,shows more differences vs.the parental than the transgenic line.Only succinic acid that falls outside the boundaries of natural variability between the two non-transgenic varieties C418 and C418/Xa23 should be further investigated with respect to safety or nutritional impact.

  3. Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism

    DEFF Research Database (Denmark)

    Büller, Harry R; Décousus, Hervé; Grosso, Michael A

    2013-01-01

    Whether the oral factor Xa inhibitor edoxaban can be an alternative to warfarin in patients with venous thromboembolism is unclear.......Whether the oral factor Xa inhibitor edoxaban can be an alternative to warfarin in patients with venous thromboembolism is unclear....

  4. Free vibration of elastically supported thin cylinders including gyroscopic effects

    CSIR Research Space (South Africa)

    Loveday, PW

    1998-10-29

    Full Text Available [ The equations D[R[ 747723 JSV 106:2 "Issue# MS 1560 VIBRATION OF THIN CYLINDERS 442 required for this procedure\\ including the gyroscopic terms\\ are included in Appendix A[ The displacement functions can then be written as follows] W"x# C0 cosh a0xa C1 sinh a0... xa C2 cos g1xa C3 sin g1xa epx:a0C4 cos qxa C5 sin qxa 1 e px:a0C6 cos qxa C7 sin qxa 1 "6a# V"x# A0C0 cosh a0xa A0C1 sinh a0xa A2C2 cos g1xa A2C3 sin g1xa epx:a$"A4C4 A5C5# cos qxa "A4C5 A5C4# sin qxa % e px:a$"A4C6 A5C7# cos...

  5. Evidence for a saturable mechanism of disappearance of standard heparin in rabbits

    International Nuclear Information System (INIS)

    Boneu, B.; Caranobe, C.; Gabaig, A.M.; Dupouy, D.; Sie, P.; Buchanan, M.R.; Hirsh, J.

    1987-01-01

    This work demonstrates that after bolus intravenous injection standard heparin (SH) disappearance results from the combination of a saturable and a non saturable mechanism. Pharmacokinetics and pharmacodynamics of SH were studied by measuring the disappearance of increasing doses (5 - 500 anti-factor Xa U/kg) of 125 I-heparin and of its biological effects. CPM curves allowed the determination of the half lives of heparin according to the dose injected. The half lives were clearly dose dependent and reached a plateau over 100 anti-factor Xa U/kg. The complex curve which describes the amount of heparin cleared per time unit after any given dose has been resolved into its two components reflecting a saturable and a non saturable mechanism of disappearance. For the doses less than 100 anti-factor Xa U/kg the saturable mechanism was preeminent and the anti-factor Xa activity disappearance followed an exponential pattern; for the doses less than 100 anti-factor Xa U/kg the contribution of the non saturable mechanism becomes more important and the anti-factor Xa activity disappearance followed a concave-convex pattern. Further experiments showed that the heparin half life shortened as the circulating anti-factor Xa activity decreased; this phenomenon may explain the concave-convex pattern of the curve of the anticoagulant effect observed after injection of large doses of SH

  6. (Biodegradable Ionomeric Polyurethanes Based on Xanthan: Synthesis, Properties, and Structure

    Directory of Open Access Journals (Sweden)

    T. V. Travinskaya

    2017-01-01

    Full Text Available New (biodegradable environmentally friendly film-forming ionomeric polyurethanes (IPU based on renewable biotechnological polysaccharide xanthan (Xa have been obtained. The influence of the component composition on the colloidal-chemical and physic-mechanical properties of IPU/Xa and based films, as well as the change of their properties under the influence of environmental factors, have been studied. The results of IR-, PMS-, DMA-, and X-ray scattering study indicate that incorporation of Xa into the polyurethane chain initiates the formation of a new polymer structure different from the structure of the pure IPU (matrix: an amorphous polymer-polymer microdomain has occurred as a result of the chemical interaction of Xa and IPU. It predetermines the degradation of the IPU/Xa films as a whole, unlike the mixed polymer systems, and plays a key role in the improvement of material performance. The results of acid, alkaline hydrolysis, and incubation into the soil indicate the increase of the intensity of degradation processes occurring in the IPU/Xa in comparison with the pure IPU. It has been shown that the introduction of Xa not only imparts the biodegradability property to polyurethane, but also improves the mechanical properties.

  7. Alternative dosing of prophylactic enoxaparin in the trauma patient: is more the answer?

    Science.gov (United States)

    Kopelman, Tammy R; O'Neill, Patrick J; Pieri, Paola G; Salomone, Jeffrey P; Hall, Scott T; Quan, Asia; Wells, Jordan R; Pressman, Melissa S

    2013-12-01

    Inadequate anti-factor Xa levels and increased venous thromboembolic events occur in trauma patients receiving standard prophylactic enoxaparin dosing. The aim of this study was to test the hypothesis that higher dosing (40 mg twice daily) would improve peak anti-Xa levels and decrease venous thromboembolism. A retrospective review was performed of trauma patients who received prophylactic enoxaparin and peak anti-Xa levels over 27 months. Patients were divided on the basis of dose: group A received 30 mg twice daily, and group B received 40 mg twice daily. Demographics and rates of venous thromboembolism were compared between dose groups and patients with inadequate or adequate anti-Xa levels. One hundred twenty-four patients were included, 90 in group A and 34 in group B. Demographics were similar, except that patients in group B had a higher mean body weight. Despite this, only 9% of group B patients had inadequate anti-Xa levels, compared with 33% of those in group A (P = .01). Imaging studies were available in 69 patients and revealed 8 venous thromboembolic events (P = NS, group A vs group B) with significantly more venous thromboembolic events occurring in patients with low anti-Xa levels (P = .02). Although higher dosing of enoxaparin led to improved anti-Xa levels, this did not equate to a statistical decrease in venous thromboembolism. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats

    Directory of Open Access Journals (Sweden)

    Nor Aziyah Mat-Rahim

    2017-01-01

    Full Text Available Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08 were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA. These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP and gamma-glutamyl transferase (GGT levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x and level of GGT (more than 2x in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.

  9. Abnormal X : autosome ratio, but normal X chromosome inactivation in human triploid cultures

    Directory of Open Access Journals (Sweden)

    Norwood Thomas H

    2006-07-01

    Full Text Available Abstract Background X chromosome inactivation (XCI is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi in normal female cells, leaving them with a single active X (Xa as in male cells. In cells with more than two X's, but a diploid autosomal complement, all X's but one, Xa, are inactivated. This phenomenon is commonly thought to suggest 1 that normal development requires a ratio of one Xa per diploid autosomal set, and 2 that an early event in XCI is the marking of one X to be active, with remaining X's becoming inactivated by default. Results Triploids provide a test of these ideas because the ratio of one Xa per diploid autosomal set cannot be achieved, yet this abnormal ratio should not necessarily affect the one-Xa choice mechanism for XCI. Previous studies of XCI patterns in murine triploids support the single-Xa model, but human triploids mostly have two-Xa cells, whether they are XXX or XXY. The XCI patterns we observe in fibroblast cultures from different XXX human triploids suggest that the two-Xa pattern of XCI is selected for, and may have resulted from rare segregation errors or Xi reactivation. Conclusion The initial X inactivation pattern in human triploids, therefore, is likely to resemble the pattern that predominates in murine triploids, i.e., a single Xa, with the remaining X's inactive. Furthermore, our studies of XIST RNA accumulation and promoter methylation suggest that the basic features of XCI are normal in triploids despite the abnormal X:autosome ratio.

  10. Xanthomonas oryzae pv. oryzae TALE proteins recruit OsTFIIAγ1 to compensate for the absence of OsTFIIAγ5 in bacterial blight in rice.

    Science.gov (United States)

    Ma, Wenxiu; Zou, Lifang; Ji, Zhiyuan; Xu, Xiameng; Xu, Zhengyin; Yang, Yangyang; Alfano, James R; Chen, Gongyou

    2018-04-28

    Xanthomonas oryzae pv. oryzae (Xoo), causal agent of bacterial blight (BB) of rice, uses transcription activator-like effectors (TALEs) to interact with the basal transcription factor gama subunit OsTFIIAγ5 (Xa5) and activates transcription of host genes. However, how OsTFIIAγ1, the other OsTFIIAγ protein, functions in the presence of TALEs remains unclear. In this study, we show that OsTFIIAγ1 plays a compensatory role in the absence of Xa5. The expression of OsTFIIAγ1, which is activated by TALE PthXo7, increased the expression of host genes targeted by avirulent and virulent TALEs. Defective OsTFIIAγ1 rice lines showed reduced expression of the TALE-targeted susceptibility (S) genes, OsSWEET11 and OsSWEET14, which resulted in increased BB resistance. Selected TALEs (PthXo1, AvrXa7, and AvrXa27) were evaluated for interactions with OsTFIIAγ1, Xa5 and xa5 (naturally-occurring mutant form of Xa5) using biomolecular fluorescence complementation (BiFC) and microscale thermophoresis (MST). BiFC and MST demonstrated that the three TALEs bind Xa5 and OsTFIIAγ1 with a stronger affinity than xa5. These results provide insight into the complex roles of OsTFIIAγ1 and OsTFIIAγ5 in TALE-mediated host gene transcription. This article is protected by copyright. All rights reserved. © 2018 BSPP and John Wiley & Sons Ltd.

  11. Nuclear techniques to address HAB concerns

    International Nuclear Information System (INIS)

    Vu Nhu Ngoc; Phan Son; Nguyen Ngoc Lam and Chu Van Thuoc

    2004-01-01

    In December, 1998, The Project Formulation meeting on application of Nuclear Techniques to address red tide (Harmful Algal Bloom concerns) was held in Manila Philippines. This is an IAEA/RCA project with the participation of Australia, China, Indonesia, Malaysia, Pakistan, The Philippines, Thailand and Vietnam. The main objectives of this project (RAS/8/076) included: - Conduct of segmentation studies to gain information on the natural histories of sediments and to correlated these with Red Tide occurrences. - Development of descriptive and predictive of the behaviour of Algal Bloom as affected by the interplay of the causative organism with the environment parameters in the water column and sediments. - Development and field testing of a rapid assay technique based on tritium - labeled saxitoxin for toxin determination. The first phase has been completed in 2002 and the second phase will be completed in 2004. In the two years of 2001 - 2002 Ted Tide occurred in very larger area in Vietnam, for example, in the coast of Binh Thuan Province with the density of 39.10 9 cells/litre. The Ministry of science - technology environment of Vietnam has support 5.000 USD each years for sediment and algal sampling in Cam Ranh Bay (Nha Trang, 11 o 45N and 10 o 15E) and Ha Long Bay in the North - East of Vietnam (21 o 15 and 107 o 3E) and in 2003 in Tuy Phong Bay (Binh Thuan province) (10 o 15N, 108 o 45E). Three sediment core has been taken from Cam Ranh Bay, Ha Long Bay and Tuy Phong Bay. The volume of sediment core is Φ = 8 cm and h = 60 cm. The algal samples have been collected by Bongo nets in Cam Ranh, Ha Long Bay and Tuy Phong Bay. (author)

  12. Efficient Methods for Fast Shading

    Directory of Open Access Journals (Sweden)

    ROMANYUK, A.

    2008-06-01

    Full Text Available On devices without battery consuming and specialized hardware for rendering, it is important to improve the speed and quality so that these methods are suitable for real-time rendering. Furthermore such algorithms are needed on the coming multicore architectures. We show how the methods by Gouraud and Phong, the commonly most used methods for shading, can be improved and made faster for both software rendering as well as simple low energy consuming hardware implementations. Moreover, this paper summarizes the authors' achievements in increasing shading speed and performance and a Bidirectional Reflectance Distribution Function is simplified for faster computing and hardware implementation.

  13. 76 FR 26253 - Marine Fisheries Advisory Committee Meeting

    Science.gov (United States)

    2011-05-06

    ...; National Ocean Policy, coastal and marine spatial planning, ocean energy and climate change adaptation... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA412 Marine Fisheries Advisory Committee Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and...

  14. Drug: D10849 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10849 Mixture ... Drug Methoxy polyethylene glycol - epoetin beta mixt; Mircera (TN...) Polyethylene glycol monomethyl ester [DR:D05554], Epoetin beta [DR:D03232] ... ATC code: B03XA03 ... PubChem: 319902649 ...

  15. Trial design: Rivaroxaban for the prevention of major cardiovascular events after transcatheter aortic valve replacement: Rationale and design of the GALILEO study

    NARCIS (Netherlands)

    Windecker, Stephan; Tijssen, Jan; Giustino, Gennaro; Guimarães, Ana H. C.; Mehran, Roxana; Valgimigli, Marco; Vranckx, Pascal; Welsh, Robert C.; Baber, Usman; van Es, Gerrit-Anne; Wildgoose, Peter; Volkl, Albert A.; Zazula, Ana; Thomitzek, Karen; Hemmrich, Melanie; Dangas, George D.

    2017-01-01

    Optimal antithrombotic treatment after transcatheter aortic valve replacement (TAVR) is unknown and determined empirically. The direct factor Xa inhibitor rivaroxaban may potentially reduce TAVR-related thrombotic complications and premature valve failure. GALILEO is an international, randomized,

  16. Dgroup: DG00137 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available DG00137 Chemical ... DGroup Calcium chloride ... C08130 ... Calcium chloride anhydrous D02256 ... Calcium... chloride (USP); Calcium chloride hydrate (JP17) ... ATC code: A12AA07 B05XA07 G04BA03 Calcium supplement ...

  17. Dgroup: DG01195 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available man serum albumin (JP17) ... D02796 ... Albumin iodinated I 131 serum (USAN) ... ATC code: V09XA03 Radioactive diagnostic... agents for Cardiovascular system, Radioactive diagnostic agents for blood volume determination ...

  18. Avaliação comparativa das propriedades de xantanas produzidas pelo patovar pruni e clairana com xantana comercial para predição de uso Comparative evaluation of xanthans properties produced by pathovar pruni and clairana with commercial xanthan to predict their uses

    Directory of Open Access Journals (Sweden)

    Patrícia D. Oliveira

    2013-01-01

    Full Text Available O presente trabalho teve como objetivo determinar a adequabilidade de três amostras de biopolímero xantana (Xa 06, Xa 82 e Xa 106 e uma clairana como viscosificantes de fluidos de perfuração de poços de petróleo, comparando com uma amostra de xantana comercial, Xanvis®. Foram realizadas análises reológicas, determinados os conteúdos de acetil, piruvato e íons Na+ K+ e Ca2+, e avaliada a capacidade viscosificante segundo norma específica da Petrobras. Os conteúdos de grupos acetil e piruvato para as xantanas e clairana diferiram significativamente entre si, mas foram compatíveis com valores preconizados ou citados na literatura concernente. Com relação ao conteúdo de íons, a xantana comercial apresentou quantidade de cálcio superior, as amostras Xa 06, Xa 82 e Xa 106 tiveram maior teor de potássio e a clairana maior teor de sódio. A viscosidade e a viscoelasticidade da amostra de xantana comercial foram superiores às demais amostras analisadas. Na análise como viscosificante para fluidos de perfuração as amostras de xantana comercial e Xa 106 atingiram os requisitos estabelecidos para os parâmetros n, K e força gel da norma Petrobras N-2605. Com a interpretação conjunta dos resultados obtidos pode-se inferir que apenas as xantanas Xanvis® e Xa 106 apresentam características adequadas à utilização como viscosificante em fluido de perfuração de petróleo. As demais amostras possuem características reológicas adequadas à utilização como espessantes ou estabilizantes em outros segmentos industriais, como em alimentos, tintas e cosméticos.The aim of this study was to determine the suitability of three xanthans (Xa 06, Xa 82 and Xa 106 and a clairana biopolymer for use as drilling fluid thickeners and comparing them against a commercial sample, Xanvis®. Rheological analyses were performed to determine the acetyl, pyruvate and Na+ K+ and Ca2+ ion content and their thickening ability, according to Petrobras

  19. Apixaban

    Science.gov (United States)

    ... medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that ... rash chest pain or tightness swelling of the face or tongue trouble breathing wheezing feeling dizzy or ...

  20. 76 FR 49735 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2011-08-11

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA631 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS.... Therese Conant, Acting Chief, Endangered Species Division, Office of Protected Resources, National Marine...

  1. Drug: D08251 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08251 Drug Nandrolone laurate; Nandrolone dodecanoate; Laurabolin [veterinary] (T...14AB01 S01XA11 Chemical group: DG00142 ... Estren derivative veterinary medicine NR3C4 (AR) [HSA:367] [KO:K085

  2. Comparison of transgenic plant production for bacterial blight ...

    African Journals Online (AJOL)

    USER

    2010-03-29

    Mar 29, 2010 ... DR - 82 with calli exposed to 300 µM acetosyringone for 2 min. ... provided by the Xa 21 gene. Key words: Transformation efficiency, selection, regeneration, resistance evaluation. ...... Shrawat AK, Becker D, Lorz H (2006).

  3. 76 FR 4551 - Hawaii Crustacean Fisheries; 2011 Northwestern Hawaiian Islands Lobster Harvest Guideline

    Science.gov (United States)

    2011-01-26

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration 50 CFR Part 665 RIN 0648-XA159 Hawaii Crustacean Fisheries; 2011 Northwestern Hawaiian Islands Lobster Harvest Guideline AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce...

  4. 76 FR 25308 - Marine Mammals

    Science.gov (United States)

    2011-05-04

    ...-XA165 Marine Mammals AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Jennifer Burns, Ph.D., University of Alaska Anchorage, Biology Department, 3101 Science Circle, Anchorage, AK, has been issued a permit to conduct [[Page 25309

  5. 76 FR 59064 - Fisheries of the Exclusive Economic Zone Off Alaska; Shallow-Water Species by Vessels Using Trawl...

    Science.gov (United States)

    2011-09-23

    .... 101126522-0640-02] RIN 0648-XA722 Fisheries of the Exclusive Economic Zone Off Alaska; Shallow- Water... closure. SUMMARY: NMFS is opening directed fishing for shallow-water species by [[Page 59065

  6. Les escamots d´aide sur cédéroms sont-ils bien perçus par les apprenants de langue étrangère ? Enquête préliminaire en France, en Angleterre et au Japon How do students perceive help pop-up windows in language learning software? A preliminary survey in France, England and Japan

    Directory of Open Access Journals (Sweden)

    Sylvain Detey

    2003-12-01

    Full Text Available Pour ceux qui s'intéressent aux outils multimédiatisés d'apprentissage, les menus en escamot (c'est-à-dire ceux qui n'apparaissent qu'à la demande de l'utilisateur se présentent comme des dispositifs particulièrement spécifiques aux documents électroniques, relevant à la fois de l'hypertextualité et de l'interactivité. Encore peu d'études, notamment dans le domaine francophone, ont examiné l'influence de ces outils sur l'apprentissage des langues, même si certains résultats d'ordre ergonomique commencent à prendre assise. Dans les cédéroms d'apprentissage de langue étrangère, les escamots sont essentiellement des escamots d'aide, destinés à assister l'apprenant dans la réalisation de tâches d'apprentissage ou de navigation. En ce sens, l'appréciation subjective de ces outils par les apprenants constitue un facteur non négligeable dans le processus d'utilisation du didacticiel. Après avoir examiné la littérature concernée, nous avons donc réalisé une première enquête préliminaire, en favorisant l'aspect quantitatif, avec un échantillon d'apprenants vaste et non homogène. Les résultats de cette enquête semblent indiquer que les apprenants perçoivent effectivement et plutôt positivement ces escamots, ce qui invite à mettre en place une étude précise, destinée à observer si l'utilisation et le bénéfice effectifs de ces dispositifs correspondent ou non à cette perception.When we look into multimedia language tools, we observe that pop-up windows (i.e. those which appear and disappear according to the learner's needs stand out as specific electronic ploys, pertaining both to hypertext and interactivity. Still, only a few studies seem to have examined in detail the influence of these tools on language learning. This is particularly true for the French-speaking research field, even though recently more and more data have been gathered. In language learning software, most of these pop-up menus are help menus, designed to help students to carry out learning or navigation tasks. It has been mentioned that the way in which students subjectively apprehend these tools has a significant impact on their use of the software. Thus after presenting a literature review, we tackle the issue through a mainly quantitative preliminary survey, with a fairly large and heterogeneous sample of students in France, England and Japan. The results indicate that students appear to be aware of these menus and that they do appreciate them. Future research will involve an in-depth study aimed at assessing the relationship between on the one hand the effective use of and benefit gained from these tools and on the other hand their subjective perception by the students.

  7. Métrica y Arquitectura del Hospital de los Reyes Católicos en Santiago de Compostela

    Directory of Open Access Journals (Sweden)

    Grande Nieto, Víctor

    2016-12-01

    Full Text Available The Catholic Kings protected several hospitals in different cities of the peninsula but promoted two directly: one in Santiago and one more in Granada, that present in its idea matrix the architectural corpus of the container well defined and isolated in that are included multitude of functions and of assistances. They are not simply hospitals, his representative function like Real building for public interest is so much important that the sanitary, it is not casual that are built in two cities in the that the Kings needed to have more presence. The grain attainment of the Crown was not so it awards his factories a decoration determined, else that they inserted in the space urban like symbolic monument of the new image of power. The analyses drawing corresponding show us a well tied building, in the that checks that Egas based in the true measures, the principle of the small whole numbers and the scale system, to apply the Arts Quadrivium to the Real Hospital and like this dignify, and the architectural discipline achieve the status of Greater Art.Aunque los Reyes Católicos protegieron varios hospitales en diferentes ciudades de la península, promovieron dos directamente: el de Santiago y el de Granada, que presentan en su idea matriz el corpus arquitectónico del contenedor bien definido y aislado en el que caben multitud de funciones y de asistencias. No son por lo tanto simplemente hospitales, su función representativa como edificio Real para interés público es tanto o más importante que la sanitaria, ya que no es casual que estén construidos en dos ciudades en las que los Reyes justamente necesitaban tener más presencia. El gran logro de la Corona no fue tanto el otorgar a sus fábricas una decoración determinada, sino el insertarlas en el espacio urbano como monumento simbólico de la nueva imagen de poder. Los análisis planimétricos correspondientes nos muestran un edificio bien trabado, en el cual se comprueba que Egas se bas

  8. Overexpression of Rice Auxilin-Like Protein, XB21, Induces Necrotic Lesions, up-Regulates Endocytosis-Related Genes, and Confers Enhanced Resistance to Xanthomonas oryzae pv. oryzae.

    Science.gov (United States)

    Park, Chang-Jin; Wei, Tong; Sharma, Rita; Ronald, Pamela C

    2017-12-01

    The rice immune receptor XA21 confers resistance to the bacterial pathogen, Xanthomonas oryzae pv. oryzae (Xoo). To elucidate the mechanism of XA21-mediated immunity, we previously performed a yeast two-hybrid screening for XA21 interactors and identified XA21 binding protein 21 (XB21). Here, we report that XB21 is an auxilin-like protein predicted to function in clathrin-mediated endocytosis. We demonstrate an XA21/XB21 in vivo interaction using co-immunoprecipitation in rice. Overexpression of XB21 in rice variety Kitaake and a Kitaake transgenic line expressing XA21 confers a necrotic lesion phenotype and enhances resistance to Xoo. RNA sequencing reveals that XB21 overexpression results in the differential expression of 8735 genes (4939 genes up- and 3846 genes down-regulated) (≥2-folds, FDR ≤0.01). The up-regulated genes include those predicted to be involved in 'cell death' and 'vesicle-mediated transport'. These results indicate that XB21 plays a role in the plant immune response and in regulation of cell death. The up-regulation of genes controlling 'vesicle-mediated transport' in XB21 overexpression lines is consistent with a functional role for XB21 as an auxilin.

  9. Integrated Production of Xylonic Acid and Bioethanol from Acid-Catalyzed Steam-Exploded Corn Stover.

    Science.gov (United States)

    Zhu, Junjun; Rong, Yayun; Yang, Jinlong; Zhou, Xin; Xu, Yong; Zhang, Lingling; Chen, Jiahui; Yong, Qiang; Yu, Shiyuan

    2015-07-01

    High-efficiency xylose utilization is one of the restrictive factors of bioethanol industrialization. However, xylonic acid (XA) as a new bio-based platform chemical can be produced by oxidation of xylose with microbial. So, an applicable technology of XA bioconversion was integrated into the process of bioethanol production. After corn stover was pretreated with acid-catalyzed steam-explosion, solid and liquid fractions were obtained. The liquid fraction, also named as acid-catalyzed steam-exploded corn stover (ASC) prehydrolyzate (mainly containing xylose), was catalyzed with Gluconobacter oxydans NL71 to prepare XA. After 72 h of bioconversion of concentrated ASC prehydrolyzate (containing 55.0 g/L of xylose), the XA concentration reached a peak value of 54.97 g/L, the sugar utilization ratio and XA yield were 94.08 and 95.45 %, respectively. The solid fraction was hydrolyzed to produce glucose with cellulase and then fermented with Saccharomyces cerevisiae NL22 to produce ethanol. After 18 h of fermentation of concentrated enzymatic hydrolyzate (containing 86.22 g/L of glucose), the ethanol concentration reached its highest value of 41.48 g/L, the sugar utilization ratio and ethanol yield were 98.72 and 95.25 %, respectively. The mass balance showed that 1 t ethanol and 1.3 t XA were produced from 7.8 t oven dry corn stover.

  10. Phosphatidylserine and Phosphatidylethanolamine Bind to Protein Z Cooperatively and with Equal Affinity.

    Directory of Open Access Journals (Sweden)

    Tanusree Sengupta

    Full Text Available Protein Z (PZ is an anticoagulant that binds with high affinity to Protein Z-dependent protease inhibitor (ZPI and accelerates the rate of ZPI-mediated inhibition of factor Xa (fXa by more than 1000-fold in the presence of Ca2+ and phospholipids. PZ promotion of the ZPI-fXa interaction results from the anchoring of the Gla domain of PZ onto phospholipid surfaces and positioning the bound ZPI in close proximity to the Gla-anchored fXa, forming a ternary complex of PZ/ZPI/fXa. Although interaction of PZ with phospholipid membrane appears to be absolutely crucial for its cofactor activity, little is known about the binding of different phospholipids to PZ. The present study was conceived to understand the interaction of different phospholipids with PZ. Experiments with both soluble lipids and model membranes revealed that PZ binds to phosphatidylserine (PS and phosphatidylethanolamine (PE with equal affinity (Kd~48 μM; further, PS and PE bound to PZ synergistically. Equilibrium dialysis experiments revealed two lipid-binding sites for both PS and PE. PZ binds with weaker affinity to other phospholipids, e.g., phosphatidic acid, phosphatidylglycerol, phosphatidylcholine and binding of these lipids is not synergistic with respect to PS. Both PS and PE -containing membranes supported the formation of a fXa-PZ complex. PZ protection of fXa from antithrombin inhibition were also shown to be comparable in presence of both PS: PC and PE: PC membranes. These findings are particularly important and intriguing since they suggest a special affinity of PZ, in vivo, towards activated platelets, the primary membrane involved in blood coagulation process.

  11. Assessment of the effects of dalteparin on coagulation variables and determination of a treatment schedule for use in cats.

    Science.gov (United States)

    Schönig, Jette C; Mischke, Reinhard H

    2016-07-01

    OBJECTIVE To determine a treatment protocol for SC administration of dalteparin to cats on the basis of currently available detailed pharmacokinetic data and to assess the effect of SC administration of dalteparin to cats on coagulation variables such as activated partial thromboplastin time (aPTT), thrombin time, and results for thromboelastometry, compared with effects on anti-activated coagulation factor X (anti-Xa) activity. ANIMALS 6 healthy domestic shorthair cats. PROCEDURES Cats received 14 injections of dalteparin (75 anti-Xa U/kg, SC) at 6-hour intervals. Blood samples were collected before and 2 hours after the first and second injections on days 1, 2, and 4. Anti-Xa activity was measured by use of a chromogenic substrate assay, aPTT and thrombin time were measured by use of an automated coagulometer, and viscoelastic measurements were obtained with thromboelastrometry. RESULTS 2 hours after the second injection, the target peak anti-Xa activity range of 0.5 to 1.0 U/mL was achieved in all cats, whereas median trough values remained below this range. Peak anti-Xa activity had only minimal effects on coagulation variables; the maximum median ratio for aPTT (in relationship to the value before the first dalteparin injection) was 1.23. CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that this treatment protocol resulted in reproducible anti-Xa activity in cats that was mostly within the targeted peak range of anti-Xa activity recommended for humans. Treatment in accordance with this protocol may not require routine coagulation monitoring of cats, but this must be confirmed in feline patients.

  12. Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway.

    Science.gov (United States)

    Xie, Zhan-Zhi; Li, Man-Mei; Deng, Peng-Fei; Wang, Sheng; Wang, Lei; Lu, Xue-Ping; Hu, Liu-Bing; Chen, Zui; Jie, Hui-Yang; Wang, Yi-Fei; Liu, Xiao-Xiao; Liu, Zhong

    2017-02-25

    Paris saponins possess anticancer, anti-inflammatory, and antiviral effects. However, the anticancer effect of Paris saponins has not been well elucidated and the mechanisms underlying the potential function of Paris saponins in cancer therapy are needed to be further identify. In this study, we report that saponin compounds isolated from Paris polyphylla exhibited antitumor activity against breast cancer cell lines, MCF-7 and MDA-MB-231. Paris saponin XA-2 induced apoptosis in both cell lines, as evidenced by the activation of caspases and cleavage of Poly (ADP-ribose) polymerase. The ability of XA-2 to induce autophagy was confirmed by acridine orange staining, accumulation of autophagosome-bound Long chain 3 (LC3)-II, and measurement of autophagic flux. XA-2-induced autophagy was observed to promote apoptosis by the combined treatment of breast cancer cell lines with XA-2 and autophagy inhibitors 3-methyladenine and bafilomycin A1, respectively. Moreover, we report a decrease in the levels of Akt/mTOR signaling pathway proteins, such as the phosphorylated forms of Akt, mTOR, P70S6K, and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1). Taken together, these results provide important insights explaining the anticancer activity of Paris saponins and the potential development of XA-2 as a new therapeutic agent. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Characterization of a disease susceptibility locus for exploring an efficient way to improve rice resistance against bacterial blight

    Institute of Scientific and Technical Information of China (English)

    Qi Cheng; Weihua Mao; Wenya Xie; Qinsong Liu; Jianbo Cao; Meng Yuan; Qinglu Zhang; Xianghua Li; Shiping Wang

    2017-01-01

    Bacterial blight caused by Xanthomonas oryzae pv.oryzae (Xoo) is the most harmful bacterial disease of rice worldwide.Previously,we characterized major disease resistance (MR) gene xa25,which confers race-specific resistance to Xoo strain PXO339.The xa25 is a recessive allele of the SWEET13 locus,but SWEET13's interaction with PXO339 and how efficiently using this locus for rice breeding still need to be defined.Here we show that the SWEET13 allele from rice Zhenshan 97 is a susceptibility gene to PXO339.Using this allele's promoter to regulate xa25 resulted in disease,suggesting that the promoter is a key determinant in SWEET13 caused disease in Zhanshan 97 after PXO339 infection.PXO339 transcriptionally induces SWEET13 to cause disease.Partial suppressing SWEET13 expression leads to a high level of resistance to PXO339.Thus,the transcriptionally suppressed SWEET13 functions as xa25 in resistance to PXO339.Hybrid rice is widely grown in many countries.However,recessive MR genes have not been efficiently used for disease resistance breeding in hybrid rice production for both parents of the hybrid have to carry the same recessive gene.However,the suppressed SWEET13 functions dominantly,which will have advantage to improve the resistance of hybrid rice to xa25-incomptible Xoo.

  14. Assessment of Heparin Anticoagulation Measured Using i-STAT and Hemochron Activated Clotting Time.

    Science.gov (United States)

    Maslow, Andrew; Chambers, Alison; Cheves, Tracey; Sweeney, Joseph

    2018-01-31

    Adequate anticoagulation, measured using activated clotting time (ACT), is important during vascular and cardiac surgeries. Unfractionated heparin is the most common anticoagulant used. The purpose of this analysis was to compare the i-STAT ACT (iACT) to the Hemochron ACT (hACT), both of which were then compared to anti-factor Xa (anti-Xa) assay, a representation of heparin level and activity. Prospective study. Tertiary care cardiovascular center. Eleven consecutive elective adult cardiac surgical patients. Prior to cardiopulmonary bypass, ACTs were measured using i-STAT and Hemochron technologies and compared to each other and to anti-Xa assay prior to and during a cumulative administration of heparin. Data were compared using bias analyses. Heparin (300 U/kg) was administered in quarterly doses. Coagulation labs were collected prior to and 3 minutes after each quarterly dose of heparin. The baseline ACTs for i-STAT and Hemochron were 147 and 142 seconds, respectively. A significant association was found between iACT and hACT (p = 0.002). The iACT measurements underestimated hACT at ACT levels >180 seconds or anti-Xa levels >0.75 U/mL. No significant difference was found between ACT data at anti-Xa levels 0.75 U/mL. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. New paleomagnetic results from the Permian and Mesozoic rocks in central and northeast Thailand: their implications for the construction of the Indochina block in Pangea

    Science.gov (United States)

    Zhang, D.; Yan, Y.; Huang, B.; Zhao, J.

    2015-12-01

    Paleomagnetic studies of the Indochina block, aiming to reconstruct the paleogeography, have been undertaken for several decades. Since the Indochina block is lack of reliable paleomagnetic data to constraint its paleo-positions during the Middle Permian to Upper Triassic, the paleogeography reconstruction is still in debate between different models reported. Here we present new paleomagnetic data of Middle Permian to Upper Triassic sediment rocks from the Indochina block in Thailand, and recalculate paleomagnetic data reported by different authors. We collected the Permian samples in 20 sites distributed in the central Thailand, and Triassic samples from the Huai Hin Lat and Nam Phong formations in 13 sites in the northern Thailand.The magnetic directions of the 11 sites of Permian limestones are not significantly clustered after tilt correction which implying a remagnetized result. Remarkably, in geographic coordinate, the 11 sites were distributed along a circle showing a similar inclination which is 22.9° implying the paleolatitude to be about 12°. Totally, 13 sites from the Huai Hin Lat formation are included in the calculation of the formation mean direction Dg/Ig = 21.4°/38.1°, kg = 19.5, α95 = 9.6° before and Ds/Is = 43.0°/48.0°, ks = 47.4, α95 = 6.1°, N = 13 after bedding correction. A pre-folding characteristic magnetization is suggested by the positive fold test result derived from the Huai Hin Lat formation, and thus implies a primary remanence of the Norian Stage Upper Triassic rocks. A new Nam Phong formation mean direction derived from 11 sites is Dg/Ig = 36.5°/31.3°, kg = 14.7, α95 = 12.3°before and Ds/Is = 36.4°/37.8°, ks = 68.5, α95 = 5.6°, N = 11 after bedding correction. The two formation mean directions correspond to the magnetic pole positions , Plat./Plon=48.7°N/165.9°E, A95=7.2° and Plat./Plon=55.2°N/178.0°E, A95=5.9°, respectively. A remarkable tectonic movement (~8° southward) of the Indochina block from the age of

  16. Oral heparin results in the appearance of heparin fragments in the plasma of rats

    International Nuclear Information System (INIS)

    Larsen, A.K.; Lund, D.P.; Langer, R.; Folkman, J.

    1986-01-01

    We have previously shown that angiogenesis inhibition and tumor regression can be accomplished by combinations of heparin or heparin fragments with cortisone. Oral heparin was also effective in combination with cortisone. We now show that a single oral dose of [ 35 S]heparin or [ 3 H]heparin (15,000 units/kg) results in continuous release of radioactive material into the bloodstream for at least 12 hr. This is associated with the presence of anti-factor Xa activity at a level of approximately equal to 0.1 unit/ml. The radioactive material is identified as oligo-, di-, and monosaccharides by its behavior in chromatographic systems, its possession of anti-factor Xa activity, and the effect of treatment with bacterial heparinase. The heparin fragments are extensively metabolized to fragments without anti-factor Xa activity that are readily subject to urinary excretion

  17. Cavalieri Integration - CSIR Technical report

    CSIR Research Space (South Africa)

    Grobler, TL

    2011-10-01

    Full Text Available ] is called a translational function. Two examples of trans- lational functions are shown in Figure 4.A and Figure 4.B, and Figure 4.C presents an example of a linear function a(y) which is not translational with respect to f(x). y f(x) xa b a(y) A. y... f(x) xa b a(y) B. y f(x) xa b a(y) C. Figure 4. Examples of translational, and non-translational functions. De nition 3.2 (Cavalieri region R). Let R be any region (in R2) bounded by a nonnegative function f(x) (which is continuous...

  18. Cavalieri integration

    CSIR Research Space (South Africa)

    Ackermann, ER

    2012-09-01

    Full Text Available ; b] is called a translational function. Two examples of translational functions are shown in Figure 4.A and Figure 4.B, and Figure 4.C presents an example of a linear function a(y) which is not translational with respect to f(x). y f(x) xa b a...(y) A. y f(x) xa b a(y) B. y f(x) xa b a(y) C. Figure 4: Examples of translational, and non-translational functions. De nition 3.2 (Cavalieri region R). Let R be any region (in R2) bounded by a nonnegative function f(x) (which is continuous...

  19. Searching Online Chemical Data Repositories via the ChemAgora Portal.

    Science.gov (United States)

    Zanzi, Antonella; Wittwehr, Clemens

    2017-12-26

    ChemAgora, a web application designed and developed in the context of the "Data Infrastructure for Chemical Safety Assessment" (diXa) project, provides search capabilities to chemical data from resources available online, enabling users to cross-reference their search results with both regulatory chemical information and public chemical databases. ChemAgora, through an on-the-fly search, informs whether a chemical is known or not in each of the external data sources and provides clikable links leading to the third-party web site pages containing the information. The original purpose of the ChemAgora application was to correlate studies stored in the diXa data warehouse with available chemical data. Since the end of the diXa project, ChemAgora has evolved into an independent portal, currently accessible directly through the ChemAgora home page, with improved search capabilities of online data sources.

  20. Fractional integration, Morrey spaces and a Schroedinger equation

    International Nuclear Information System (INIS)

    Olsen, P.A.

    1995-01-01

    Let V : R 3 → R be the potential for the 3-dimensional Schroedinger operator -Δ + V. It was shown by Cwikel, Lieb and Rosenblum, [8], that the number of bound states, N(V), of -Δ + V is bounded by N(V) ≤ C ∫ R3 |V(x)| 3/2 dx. Later Fefferman and phong, [4], improved on this inequality. Make a dyadic decomposition of R 3 into cubes. Define a dyadic cube Q to be minimal with respect to ε > 0 if ∫ q |V(x)| p dx ≥ ε p |Q| 1-2p/3 and ∫ Q ' |V(x)| p dx p |Q'| 1-2p/3 for all dyadic cubes Q' contained-in Q. 10 refs., 4 figs., 1 tab

  1. One-instanton test of a Seiberg-Witten curve from M-theory: the antisymmetric representation of SU(N)

    International Nuclear Information System (INIS)

    Naculich, S.G.; Schnitzer, H.J.

    1998-01-01

    One-instanton predictions are obtained from the Seiberg-Witten curve derived from M-theory by Landsteiner and Lopez for the Coulomb branch of N=2 supersymmetric SU(N) gauge theory with a matter hypermultiplet in the antisymmetric representation. Since this cubic curve describes a Riemann surface that is non-hyperelliptic, a systematic perturbation expansion about a hyperelliptic curve is developed, with a comparable expansion for the Seiberg-Witten differential. Calculation of the period integrals of the SW differential by the method of residues of D'Hoker, Krichever, and Phong enables us to compute the prepotential explicitly to one-instanton order. It is shown that the one-instanton predictions for SU(2), SU(3), and SU(4) agree with previously available results. For SU(N), N≥5, our analysis provides explicit predictions of a curve derived from M-theory at the one-instanton level in field theory. (orig.)

  2. Introduction to bosonic string theory

    Energy Technology Data Exchange (ETDEWEB)

    Nunez, Carmen [Instituto de Astronomia y Fisica del Espacio, Buenos Aires (Argentina)], e-mail: carmen@iafe.uba.ar

    2009-07-01

    This is an introductory set of five lectures on bosonic string theory. The first one deals with the classical theory of bosonic strings. The second and third lectures cover quantization. Three basic quantization methods are sketched: the old covariant formalism, the light-cone gauge quantization, where the spectrum is derived and the Polyakov path integral formalism and in particular the partition function at one loop. Finally, the last lecture covers interactions, low energy effective action, the general idea of compactification and in particular toroidal compactification. The notes are based on books by Green, Schwarz and Witten, Polchinski, Lust and Theissen and Kaku and review papers by D'Hocker and Phong and O. Alvarez. (author)

  3. Illuminance: Computerized simulation

    Energy Technology Data Exchange (ETDEWEB)

    Barlow, A

    1991-03-01

    One of the main objectives of a graphics work-station is to create images that are as realistic as possible. This paper reviews and assesses the state-of-the-art in the field of illuminance simulation. The techniques examined are: ray tracing, in which illuminance in a given ambient is calculated in an approximate way by tracing individual rays of light; the 'radiosity' (a term combining surface radiancy and reflectivity) method, based on the calculation of the ambient's thermodynamics and which considers the effects of different surface colours; progressive improvement, in which 'radiosity' is calculated step by step with increasing levels of detail. The Gouraud and Phong methods of representing the effects of shade are also compared.

  4. A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

    Science.gov (United States)

    Dunford, Linda; Carr, Michael J; Dean, Jonathan; Nguyen, Linh Thuy; Ta Thi, Thu Hong; Nguyen, Binh Thanh; Connell, Jeff; Coughlan, Suzie; Nguyen, Hien Tran; Hall, William W; Thi, Lan Anh Nguyen

    2012-01-01

    Hepatitis B (HBV) infection is endemic in Viet Nam, with up to 8.4 million individuals estimated to be chronically infected. We describe results of a large, multicentre seroepidemiological and molecular study of the prevalence of HBV infection and blood-borne viral coinfections in Viet Nam. Individuals with varying risk factors for infection (n = 8654) were recruited from five centres; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. A mean prevalence rate of 10.7% was observed and levels of HBsAg were significantly higher in injecting drug users (IDUs) (17.4%, n = 174/1000) and dialysis patients (14.3%, n = 82/575) than in lower-risk groups (9.4%; pViet Nam and also highlights the significant levels of blood-borne virus coinfections, which have important implications for hepatitis-related morbidity and development of effective management strategies.

  5. Agent Orange Footprint Still Visible in Rural Areas of Central Vietnam

    Directory of Open Access Journals (Sweden)

    Jan Banout

    2014-01-01

    Full Text Available Levels of polychlorinated dioxins/furans (PCDD/PCDF in selected environmental samples (soils, sediments, fish, and farm animals were analyzed from the area of Phong My commune (Thua Thien-Hue province, Vietnam. This area was affected by Agent Orange spraying during the Vietnam war (1968–1971. Whereas PCDD/PCDF content in soil and sediment samples is relatively low and ranges between 0.05 and 5.1 pg WHO-TEQ/g for soils and between 0.7 and 6.4 pg WHO-TEQ/g for sediments, the PCDD/PCDF content in poultry muscle and liver in most cases exceeded the maximum permissible limit of dioxin content per unit fat mass. In some cases of soil and sediments samples, 2,3,7,8-TCDD represented more than 90% of the total PCDD/PCDF, which indicates Agent Orange as the main source.

  6. Simulating Ru L 3 -Edge X-ray Absorption Spectroscopy with Time-Dependent Density Functional Theory: Model Complexes and Electron Localization in Mixed-Valence Metal Dimers

    Energy Technology Data Exchange (ETDEWEB)

    Van Kuiken, Benjamin E.; Valiev, Marat; Daifuku, Stephanie L.; Bannan, Caitlin; Strader, Matthew L.; Cho, Hana; Huse, Nils; Schoenlein, Robert W.; Govind, Niranjan; Khalil, Munira

    2013-05-30

    Ruthenium L3-edge X-ray absorption (XA) spectroscopy probes unoccupied 4d orbitals of the metal atom and is increasingly being used to investigate the local electronic structure in ground and excited electronic states of Ru complexes. The simultaneous development of computational tools for simulating Ru L3-edge spectra is crucial for interpreting the spectral features at a molecular level. This study demonstrates that time-dependent density functional theory (TDDFT) is a viable and predictive tool for simulating ruthenium L3-edge XA spectroscopy. We systematically investigate the effects of exchange correlation functional and implicit and explicit solvent interactions on a series of RuII and RuIII complexes in their ground and electronic excited states. The TDDFT simulations reproduce all of the experimentally observed features in Ru L3-edge XA spectra within the experimental resolution (0.4 eV). Our simulations identify ligand-specific charge transfer features in complicated Ru L3-edge spectra of [Ru(CN)6]4- and RuII polypyridyl complexes illustrating the advantage of using TDDFT in complex systems. We conclude that the B3LYP functional most accurately predicts the transition energies of charge transfer features in these systems. We use our TDDFT approach to simulate experimental Ru L3-edge XA spectra of transition metal mixed-valence dimers of the form [(NC)5MII-CN-RuIII(NH3)5] (where M = Fe or Ru) dissolved in water. Our study determines the spectral signatures of electron delocalization in Ru L3-edge XA spectra. We find that the inclusion of explicit solvent molecules is necessary for reproducing the spectral features and the experimentally determined valencies in these mixed-valence complexes. This study validates the use of TDDFT for simulating Ru 2p excitations using popular quantum chemistry codes and providing a powerful interpretive tool for equilibrium and ultrafast Ru L3-edge XA spectroscopy.

  7. An ultrasensitive electrochemical sensor for simultaneous determination of xanthine, hypoxanthine and uric acid based on Co doped CeO{sub 2} nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Lavanya, N. [Department of Bioelectronics and Biosensors, Alagappa University, Karaikudi 630003, Tamilnadu (India); Sekar, C., E-mail: Sekar2025@gmail.com [Department of Bioelectronics and Biosensors, Alagappa University, Karaikudi 630003, Tamilnadu (India); Murugan, R.; Ravi, G. [Department of Physics, Alagappa University, Karaikudi 630003, Tamilnadu (India)

    2016-08-01

    A novel electrochemical sensor has been fabricated using Co doped CeO{sub 2} nanoparticles for selective and simultaneous determination of xanthine (XA), hypoxanthine (HXA) and uric acid (UA) in a phosphate buffer solution (PBS, pH 5.0) for the first time. The Co-CeO{sub 2} NPs have been prepared by microwave irradiation method and characterized by Powder XRD, Raman spectroscopy, HRTEM and VSM measurements. The electrochemical behaviours of XA, HXA and UA at the Co-CeO{sub 2} NPs modified glassy carbon electrode (GCE) were studied by cyclic voltammetry and square wave voltammetry methods. The modified electrode exhibited remarkably well-separated anodic peaks corresponding to the oxidation of XA, HXA and UA over the concentration range of 0.1–1000, 1–600 and 1–2200 μM with detection limits of 0.096, 0.36, and 0.12 μM (S/N = 3), respectively. For simultaneous detection by synchronous change of the concentrations of XA, HXA and UA, the linear responses were in the range of 1–400 μM each with the detection limits of 0.47, 0.26, and 0.43 μM (S/N = 3), respectively. The fabricated sensor was further applied to the detection of XA, HXA and UA in human urine samples with good selectivity and high reproducibility. - Highlights: • A novel electrochemical sensor has been fabricated for simultaneous determination of purine metabolites xanthine, hypoxanthine, and uric acid based on Co doped CeO{sub 2} nanoparticles. • The Co-CeO{sub 2} modified glassy carbon electrode exhibited wide linear range towards the detection of XA, HXA and UA than ever reported in the literature. • The fabricated sensor was successfully applied for the analysis of human urine samples with satisfactory results.

  8. Simulating Ru L3-edge X-ray absorption spectroscopy with time-dependent density functional theory: model complexes and electron localization in mixed-valence metal dimers.

    Science.gov (United States)

    Van Kuiken, Benjamin E; Valiev, Marat; Daifuku, Stephanie L; Bannan, Caitlin; Strader, Matthew L; Cho, Hana; Huse, Nils; Schoenlein, Robert W; Govind, Niranjan; Khalil, Munira

    2013-05-30

    Ruthenium L3-edge X-ray absorption (XA) spectroscopy probes unoccupied 4d orbitals of the metal atom and is increasingly being used to investigate the local electronic structure in ground and excited electronic states of Ru complexes. The simultaneous development of computational tools for simulating Ru L3-edge spectra is crucial for interpreting the spectral features at a molecular level. This study demonstrates that time-dependent density functional theory (TDDFT) is a viable and predictive tool for simulating ruthenium L3-edge XA spectroscopy. We systematically investigate the effects of exchange correlation functional and implicit and explicit solvent interactions on a series of Ru(II) and Ru(III) complexes in their ground and electronic excited states. The TDDFT simulations reproduce all of the experimentally observed features in Ru L3-edge XA spectra within the experimental resolution (0.4 eV). Our simulations identify ligand-specific charge transfer features in complicated Ru L3-edge spectra of [Ru(CN)6](4-) and Ru(II) polypyridyl complexes illustrating the advantage of using TDDFT in complex systems. We conclude that the B3LYP functional most accurately predicts the transition energies of charge transfer features in these systems. We use our TDDFT approach to simulate experimental Ru L3-edge XA spectra of transition metal mixed-valence dimers of the form [(NC)5M(II)-CN-Ru(III)(NH3)5](-) (where M = Fe or Ru) dissolved in water. Our study determines the spectral signatures of electron delocalization in Ru L3-edge XA spectra. We find that the inclusion of explicit solvent molecules is necessary for reproducing the spectral features and the experimentally determined valencies in these mixed-valence complexes. This study validates the use of TDDFT for simulating Ru 2p excitations using popular quantum chemistry codes and providing a powerful interpretive tool for equilibrium and ultrafast Ru L3-edge XA spectroscopy.

  9. Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal A. Rich (Annonaceae and the major constituent, xylopic acid in murine models

    Directory of Open Access Journals (Sweden)

    Eric Woode

    2012-01-01

    Full Text Available Background: Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including rheumatism, headache, colic pain, and neuralgia. Little pharmacological data exists in scientific literature of the effect of the fruit extract and its major diterpene, xylopic acid, on pain. The present study evaluated the analgesic properties of the ethanol extract of X. aethiopica (XAE and xylopic acid (XA, in murine models. Materials and Methods: XAE and XA were assessed in chemical (acetic acid-induced abdominal writhing and formalin tests, thermal (Tail-flick and Hargreaves thermal hyperalgesia tests, and mechanical (Randall-Selitto paw pressure test pain models. Results: XAE and XA exhibited significant analgesic activity in all the pain models used. XAE (30-300 mg kg -1 , p.o. and XA (10-100 mg kg -1 , p.o. inhibited acetic acid-induced visceral nociception, formalin- induced paw pain (both neurogenic and inflammatory, thermal pain as well as carrageenan-induced mechanical and thermal hyperalgesia in animals. Morphine (1-10 mg kg -1 , i.p. and diclofenac (1-10 mg kg -1 , i.p., used as controls, exhibited similar anti-nociceptive activities. XAE and XA did not induce tolerance to their respective anti-nociceptive effects in the formalin test after chronic administration. Morphine tolerance did not also cross-generalize to the analgesic effects of XAE or XA. Conclusions: These findings establish the analgesic properties of the ethanol fruit extract of X. aethiopica and its major diterpene, xylopic acid.

  10. Apixaban or enoxaparin for thromboprophylaxis after knee replacement

    DEFF Research Database (Denmark)

    Lassen, Michael Rud; Raskob, Gary E; Gallus, Alexander

    2009-01-01

    BACKGROUND: The optimal strategy for thromboprophylaxis after major joint replacement has not been established. Low-molecular-weight heparins such as enoxaparin predominantly target factor Xa but to some extent also inhibit thrombin. Apixaban, a specific factor Xa inhibitor, may provide effective...... (P=0.03). CONCLUSIONS: As compared with enoxaparin for efficacy of thromboprophylaxis after knee replacement, apixaban did not meet the prespecified statistical criteria for noninferiority, but its use was associated with lower rates of clinically relevant bleeding and it had a similar adverse...

  11. Finsler-Geometric Continuum Dynamics and Shock Compression

    Science.gov (United States)

    2018-01-01

    version of Finsler theory is newly applied to shock compression of this ceramic. An order parameter is linked simultaneously to densification and...set of algebraic equations that may be solved simultaneously (albeit, not in closed form) for the shock stress, order param- eter, entropy, and shock...δxa ⊗ dX A = ∂ϕ a(X, D, t) ∂X A δ δxa ⊗ dX A = ∂x(X, D, t) ∂X , FaA = ∂Aϕa = ∂Axa . (2.28) The inverse tangent mapping from spatial to referential

  12. Guidance of Autonomous Aerospace Vehicles for Vertical Soft Landing using Nonlinear Control Theory

    Science.gov (United States)

    2015-08-11

    desired plant (1.4) i.e. goal is to ensure that X → Xd as t →∞. 4 Distribution Code A: Approved for public release, distribution is unlimited 1.1 Philosophy...system to follow Ẋd = fd ( Xd ) (1.4) where Xd ∈ℜn represents the desire state vector. In the actual plant model (1.3) the term d(X ) is unknown, the...Kτ(Xest −Xa) (1.6) 2. Xa → Xd as t →∞: This process is accomplished through control synthesis using online adaptation of DI controller. 1.1.1 Control

  13. Normal Female Germ Cell Differentiation Requires the Female X Chromosome to Autosome Ratio and Expression of Sex-Lethal in DROSOPHILA MELANOGASTER

    OpenAIRE

    Schüpbach, Trudi

    1985-01-01

    In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss of an unstable ring-X chromosome, contained some germ cells of 2X;3A constitution in their ovaries. Such germ cells were shown to differentiate along one of two alternative pat...

  14. DynaGuard: Armoring Canary-Based Protections against Brute-Force Attacks

    Science.gov (United States)

    2015-12-11

    format of the canary check or a function’s prologue and epilogue. Finally, due to the small number of canary-protected frames that (on average) are...sje ng 462 .lib qua ntu m 464 .h2 64r ef 471 .om net pp 473 .as tar 483 .xa lan cbm k Apa che Ng inx Pos tgre SQ L SQ Lite My SQ L Sl ow do w n (n...k 456 .hm me r 458 .sje ng 462 .lib qua ntu m 464 .h2 64r ef 471 .om net pp 473 .as tar 483 .xa lan cbm k Apa che Ng inx

  15. Case report

    African Journals Online (AJOL)

    abp

    21 sept. 2017 ... XA avait aux deux yeux, une AV à 8/10 et XB, une AV de 3/10 améliorée au trou sténopéïque à 7/10 en faveur d'une amétropie. XA présentait un ptosis bilatéral qui remontait à l'âge de 2 ans avec une action du releveur de la paupière supérieure (RPS) à 7 mm et XB, un ptosis bilatéral remontant à l'âge de ...

  16. Ultrahigh-efficiency apodized grating coupler using fully etched photonic crystals

    DEFF Research Database (Denmark)

    Ding, Yunhong; Ou, Haiyan; Peucheret, Christophe

    2013-01-01

    We present an efficient method to design apodized grating couplers with Gaussian output profiles for efficient coupling between standard single mode fibers and silicon chips. An apodized grating coupler using fully etched photonic crystal holes on the silicon-on-insulator platform is designed......, and fabricated in a single step of lithography and etching. An ultralow coupling loss of x2212;1.74x2009;x2009;dB (67% coupling efficiency) with a 3xA0;dB bandwidth of 60xA0;nm is experimentally measured....

  17. 1st review of the status of national air quality: 1994-2004

    CSIR Research Space (South Africa)

    Taviv, I

    2006-10-01

    Full Text Available od (WC ) Se ttle rs (KZ N) We ntw or th (KZ N) Wa ter va l (M P) Ta ble Vie w (WC ) Mo the rw ell (EC ) Le itru m (FS ) Ale xa ndr a (GA U) Ora nge Fa rm (GA U) Kh aye lits ha (WC ) Ne...) La ng ve rw ac ht (MP ) Le itru m (FS ) Ale xa nd ra (GA U) At hlo ne (WC ) Bu cc leu ch (GA U) Cit y D ee p(G AU ) Ne wt ow n (GA U) No rth er n Wo rks (GA U) O 3 ( p p b ) Average...

  18. Notice sur la Tyana superba, Moore

    NARCIS (Netherlands)

    Snellen, P.C.T.

    1890-01-01

    Monsieur Ritsema, ayant reçu de Mr. A. L. van Hasselt, Résident à Padang Sidempoean (Sumatra occid.), pour le Musée de Leide, un exemplaire très-frais et assez bien conservé de cette belle espèce, qui mérite bien son nom, me permit à ma demande de l’examiner afin de bien déterminer sa position

  19. Aprendizaje en la producción de capital, crecimiento acelerado y cambio estructural

    Directory of Open Access Journals (Sweden)

    Ortiz Carlos Humberto

    2008-08-01

    Full Text Available Con base en un modelo bisectorial de crecimiento endógeno (Rebelo
    1991, en el cual se produce un bien de consumo y un bien de capital, en este artículo se analiza el efecto de suponer aprendizaje en la práctica en el sector productor del bien de capital. El modelo modificado reproduce dos patrones del desarrollo económico de largo plazo: crecimiento acelerado y cambio estructural.

  20. African Journal of Biotechnology - Vol 8, No 21 (2009)

    African Journals Online (AJOL)

    Analyses of karyotypes and comparative physical locations of the resistance gene, Xa-5, between Oryza sativa and Oryza,/i> officinalis · EMAIL FREE FULL .... Phytochemical constituents and effects of aqueous root-bark extract of Ficus sycomorus L. (Moracaea) on muscular relaxation, anaesthetic and sleeping time on ...

  1. Sen char nsory, acteris pequ physi stics o i (Cary coche of Gree ...

    African Journals Online (AJOL)

    SAM

    purchase in. 1), 1% pequ .... xa Postal 66, s II da UFG, .... the exposure of consumers to high risks of contamination by a ... After the addition of the culture, the milk was kept at 42°C in .... and Robinson (1999), who studied the behavior of starter.

  2. 78 FR 20317 - Application for Final Commitment for a Long-Term Loan or Financial Guarantee in Excess of $100...

    Science.gov (United States)

    2013-04-04

    ... supplying information that competitors could use to compete with companies in the United States. DATES... or Financial Guarantee in Excess of $100 Million: AP087223XX and AP087223XA AGENCY: Export-Import...''), that Ex-Im Bank has received an application for final commitment for a long-term loan or financial...

  3. Simukunin from the Salivary Glands of the Black Fly Simulium vittatum Inhibits Enzymes That Regulate Clotting and Inflammatory Responses

    Czech Academy of Sciences Publication Activity Database

    Tsujimoto, H.; Kotsyfakis, Michalis; Francischetti, I.M.B.; Eum, J. H.; Strand, M. R.; Champagne, D. E.

    2012-01-01

    Roč. 7, č. 2 (2012), e29964 E-ISSN 1932-6203 Institutional research plan: CEZ:AV0Z60220518 Keywords : Simulium vittatum * Kunitz-family protein * elastase * cathepsin G * Factor Xa * coagulation * inflammation * serine proteases * BPTI-like inhibitor * Simukunin Subject RIV: EC - Immunology Impact factor: 3.730, year: 2012

  4. Abscisic acid, xanthoxin and violaxanthin in the caps of gravistimulated maize roots

    Science.gov (United States)

    Feldman, L. J.; Arroyave, N. J.; Sun, P. S.

    1985-01-01

    The occurrence and distribution of abscisic acid (ABA), xanthoxin (Xa) and the carotenoid violaxanthin (Va) were investigated in root tips of maize (Zea mays L. cv. Merit). In roots grown in the dark, Va and ABA were present in relatively high amounts in the root cap and in low amounts in the adjacent terminal 1.5 mm of the root. Xanthoxin was present in equal concentrations in both regions. In roots exposed to light, the ABA distribution was reversed, with relatively low levels in the root cap and high levels in the adjacent 1.5-mm segment. Light also caused a decrease in Va in both regions of the root and an increase in Xa, especially in the cap. In the maize cultivar used for this work, light is necessary for gravitropic curving. This response occurs within the same time frame as the light-induced ABA redistribution as well as the changes in the levels of Va and Xa. These data are consistent with a role for ABA in root gravitropism and support the proposal that Xa may arise from the turnover of Va.

  5. 77 FR 2037 - Marine Mammals; Photography Permit File No. 17032

    Science.gov (United States)

    2012-01-13

    ... filmmaker hopes to document the behavior of marine animals in the presence of a gray whale carcass. Filming... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA929 Marine Mammals; Photography Permit File No. 17032 AGENCY: National Marine Fisheries Service (NMFS), National...

  6. 77 FR 24470 - Marine Mammals; Photography Permit File No. 17032

    Science.gov (United States)

    2012-04-24

    ... behavior of marine animals in the presence of a gray whale carcass. Filming will occur between April and... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA929 Marine Mammals; Photography Permit File No. 17032 AGENCY: National Marine Fisheries Service (NMFS), National...

  7. 76 FR 56167 - Marine Mammals; Pinniped Removal Authority

    Science.gov (United States)

    2011-09-12

    ... problem interactions. See http://www.nwr.noaa.gov/Marine-Mammals/Seals-and-Sea-Lions/Sec-120-Authority.cfm... to the pinniped predation problem at Bonneville Dam and is not a na[iuml]ve animal that can be driven... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA681 Marine...

  8. Incorporation of Bacterial Blight Resistance Genes Into Lowland Rice Cultivar Through Marker-Assisted Backcross Breeding.

    Science.gov (United States)

    Pradhan, Sharat Kumar; Nayak, Deepak Kumar; Pandit, Elssa; Behera, Lambodar; Anandan, Annamalai; Mukherjee, Arup Kumar; Lenka, Srikanta; Barik, Durga Prasad

    2016-07-01

    Bacterial blight (BB) of rice caused by Xanthomonas oryzae pv. oryzae is a major disease of rice in many rice growing countries. Pyramided lines carrying two BB resistance gene combinations (Xa21+xa13 and Xa21+xa5) were developed in a lowland cultivar Jalmagna background through backcross breeding by integrating molecular markers. In each backcross generation, markers closely linked to the disease resistance genes were used to select plants possessing the target genes. Background selection was continued in those plants carrying resistant genes until BC(3) generation. Plants having the maximum contribution from the recurrent parent genome were selected in each generation and hybridized with the recipient parent. The BB-pyramided line having the maximum recipient parent genome recovery of 95% was selected among BC3F1 plants and selfed to isolate homozygous BC(3)F(2) plants with different combinations of BB resistance genes. Twenty pyramided lines with two resistance gene combinations exhibited high levels of tolerance against the BB pathogen. In order to confirm the resistance, the pyramided lines were inoculated with different X. oryzae pv. oryzae strains of Odisha for bioassay. The genotypes with combination of two BB resistance genes conferred high levels of resistance to the predominant X. oryzae pv. oryzae isolates prevalent in the region. The pyramided lines showed similarity with the recipient parent with respect to major agro-morphologic traits.

  9. 77 FR 2513 - Draft Environmental Impact Statement for Effects of Oil and Gas Activities in the Arctic Ocean

    Science.gov (United States)

    2012-01-18

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA934 Draft Environmental Impact Statement for Effects of Oil and Gas Activities in the Arctic Ocean AGENCY: National Marine... Environmental Impact Statement (DEIS) for the Effects of Oil and Gas Activities in the Arctic Ocean.'' Based on...

  10. Disappearance of a low molecular weight heparin fraction (CY 216) differs from standard heparin in rabbits

    International Nuclear Information System (INIS)

    Boneu, B.; Buchanan, M.R.; Caranobe, C.; Gabaig, A.M.; Dupouy, D.; Sie, P.; Hirsh, J.

    1987-01-01

    In previous studies, we have reported that standard heparin (SH) was cleared by two mechanisms, a saturable mechanism which predominated at low doses (less than 100 anti-factor Xa U/kg) and a non-saturable mechanism which predominated at higher doses, when the first mechanism became saturated. In this study, we examined the importance of these two mechanisms in the disappearance of a low molecular weight heparin fraction (LMWH) (CY 216), by comparing the pharmacokinetics and the pharmacodynamics of a wide range of doses of SH and CY 216 (1.5 to 500 anti-factor Xa U/kg). Pharmacokinetics was measured as the disappearance of 125 I-radiolabelled SH or CY 216. Pharmacodynamics was measured as the disappearance of the anti-factor Xa activity of SH and CY 216. We found that the saturable mechanism contributed little to the disappearance of CY 216 and that it was cleared predominantly by the non-saturable mechanism at all doses tested. Thus, at low doses (less than 100 anti-factor Xa U/kg), SH was cleared more rapidly than CY 216, whereas at higher doses, CY 216 was cleared more rapidly than SH. We conclude that the mechanism of disappearance of LMWH's differ significantly from those of SH, and that this difference may explain the apparent prolonged anticoagulant activity of LMWH's within the therapeutic range doses

  11. 76 FR 41764 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Coral and Coral Reefs off the...

    Science.gov (United States)

    2011-07-15

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration [RIN 0648-XA491] Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Coral and Coral Reefs off the Southern Atlantic... sanctuaries, special management zones, or artificial reefs without additional authorization. A report on the...

  12. 77 FR 32572 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Coral and Coral Reefs Off the...

    Science.gov (United States)

    2012-06-01

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA935 Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Coral and Coral Reefs Off the Southern Atlantic... conditions, various species of reef fish, crabs, and lobsters in Federal waters off South Carolina and North...

  13. 76 FR 17434 - Receipt of Application for an Endangered Species Act Incidental Take Permit

    Science.gov (United States)

    2011-03-29

    ... Atmospheric Administration RIN 0648-XA020 Receipt of Application for an Endangered Species Act Incidental Take..., the Services) for incidental take permits (ITPs) under the Endangered Species Act of 1973, as amended...) and implementing regulations prohibit the taking of animal species listed as endangered or threatened...

  14. Ramjets and Ramrockets for Military Applications

    Science.gov (United States)

    1982-03-01

    or auni)from multiple platforms and other operational considerations e-posed in recent XA1(o/nf~ studies should not invalidate the above claim. of...thereby obviating the need for any evaporation time. To ascertain the degree of pre- wix , carbon dioxide (selected because of its denasity similarit7

  15. Gas-phase infrared spectrum of the anionic GFP-chromophore

    NARCIS (Netherlands)

    Almasian, M.; Grzetic, J.; G. Berden,; Bakker, B.; Buma, W. J.; Oomens, J.

    2012-01-01

    The gas-phase IR spectrum of the anionic chromophore of the green fluorescent protein (p-hydroxy-benzylidene-2,3-dimethylimidazolidinone, HBDI) is recorded in the 800–1800&#xa0;cm−1 frequency range using the free electron laser FELIX in combination with an electrospray ionization (ESI) Fourier

  16. Hydrogenic donor in a quantum well with an electric field

    International Nuclear Information System (INIS)

    Jayakumar, K.; Balasubramanian, S.; Tomak, M.

    1985-08-01

    Variational calculations of the binding energy of a hydrogenic donor in a quantum well formed by GaAs and Gasub(1-x)A1sub(x)As with a constant electric field are performed for different electric fields and well widths. A critical electric field is defined and its variation with well width is presented. (author)

  17. Computation of the modified Bessel function of the third kind of imaginary orders: uniform Airy-type asymptotic expansion

    NARCIS (Netherlands)

    A. Gil (Amparo); J. Segura (Javier); N.M. Temme (Nico)

    2002-01-01

    textabstractThe use of a uniform Airy-type asymptotic expansion for the computation of the modified Bessel functions of the third kind of imaginary orders ($K_{ia}(x)$) near the transition point $x=a$, is discussed. In [2], an algorithm for the evaluation of $K_{ia}(x)$ was presented, which made use

  18. Neutral V production with 14.6 x A GeV/c silicon beams

    International Nuclear Information System (INIS)

    Eiseman, S.E.; Etkin, A.; Foley, K.J.; Hackenburg, R.W.; Longacre, R.S.; Love, W.A.; Morris, T.W.; Platner, E.D.; Saulys, A.C.; Lindenbaum, S.J.; Chan, C.S.; Kramer, M.A.; Zhao, K.; Hallman, T.J.; Madansky, L.; Bonner, B.E.; Buchanan, J.A.; Chiou, C.N.; Clement, J.M.; Corcoran, M.D.; Kruk, J.W.; Mutchler, G.S.; Nessi-Tedaldi, F.; Nessi, M.; Roberts, J.B.

    1990-01-01

    We present the results of a measurement of neutral V production with 14.6xA GeV/c Si beams on Au and Cu targets. The Λ and K s 0 yields were measured as a function of negative particle multiplicity. Effective temperatures were determined from an exponential fit to the transverse mass distributions. (orig.)

  19. A novel protease activity assay using a protease-responsive chaperone protein

    International Nuclear Information System (INIS)

    Sao, Kentaro; Murata, Masaharu; Fujisaki, Yuri; Umezaki, Kaori; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki; Hashizume, Makoto

    2009-01-01

    Protease activity assays are important for elucidating protease function and for developing new therapeutic agents. In this study, a novel turbidimetric method for determining the protease activity using a protease-responsive chaperone protein is described. For this purpose, a recombinant small heat-shock protein (sHSP) with an introduced Factor Xa protease recognition site was synthesized in bacteria. This recombinant mutant, FXa-HSP, exhibited chaperone-like activity at high temperatures in cell lysates. However, the chaperone-like activity of FXa-HSP decreased dramatically following treatment with Factor Xa. Protein precipitation was subsequently observed in the cell lysates. The reaction was Factor Xa concentration-dependent and was quantitatively suppressed by a specific inhibitor for Factor Xa. Protein aggregation was detected by a simple method based on turbidimetry. The results clearly demonstrate that this assay is an effective, easy-to-use method for determining protease activities without the requirement of labeling procedures and the use of radioisotopes.

  20. A novel protease activity assay using a protease-responsive chaperone protein

    Energy Technology Data Exchange (ETDEWEB)

    Sao, Kentaro [Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395 (Japan); Murata, Masaharu, E-mail: m-murata@dem.med.kyushu-u.ac.jp [Department of Advanced Medical Initiatives, Faculty of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 (Japan); Fujisaki, Yuri; Umezaki, Kaori [Department of Advanced Medical Initiatives, Faculty of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 (Japan); Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki [Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395 (Japan); Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Nishi-ku Fukuoka 819-0395 (Japan); Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan); Hashizume, Makoto [Department of Advanced Medical Initiatives, Faculty of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 (Japan)

    2009-06-05

    Protease activity assays are important for elucidating protease function and for developing new therapeutic agents. In this study, a novel turbidimetric method for determining the protease activity using a protease-responsive chaperone protein is described. For this purpose, a recombinant small heat-shock protein (sHSP) with an introduced Factor Xa protease recognition site was synthesized in bacteria. This recombinant mutant, FXa-HSP, exhibited chaperone-like activity at high temperatures in cell lysates. However, the chaperone-like activity of FXa-HSP decreased dramatically following treatment with Factor Xa. Protein precipitation was subsequently observed in the cell lysates. The reaction was Factor Xa concentration-dependent and was quantitatively suppressed by a specific inhibitor for Factor Xa. Protein aggregation was detected by a simple method based on turbidimetry. The results clearly demonstrate that this assay is an effective, easy-to-use method for determining protease activities without the requirement of labeling procedures and the use of radioisotopes.

  1. 77 FR 35355 - User Fee Schedule for Trade Promotion Services

    Science.gov (United States)

    2012-06-13

    ...-XA17 User Fee Schedule for Trade Promotion Services AGENCY: U.S. & Foreign Commercial Service... promotion services under the current fee structure. ITA provides a wide range of trade promotion information... these more intensive trade promotion services. The fee revenue is expected to continue to contribute to...

  2. Identification of Bacterial Plant Pathogens Using Multilocus Polymerase Chain Reaction/Electrospray Ionization-Mass Spectrometry

    Science.gov (United States)

    2008-01-01

    pathogens also have been detected and identified by numerous nucleic acid-based techniques, including Southern blot hybridization and direct nucleotide...Xanthomonas axonopodis pv. vitians FB-1309; ATCC19320 Lettuce ; USA 1 Xanthomonas axonopodis sp. alfalfae XA129; Med. 2 Alfalfa; Sudan 1 Xanthomonas

  3. New oral anticoagulant-induced bleeding: clinical presentation and management

    NARCIS (Netherlands)

    Levy, Jerrold H.; Levi, Marcel

    2014-01-01

    Bleeding is a significant complication of anticoagulant therapy. With the emergence of new oral anticoagulants (NOACs; ie, direct factor IIa or Xa inhibitors), this risk is further compounded by the lack of validated reversal strategies for these agents. Emerging postmarketing evidence suggests that

  4. 76 FR 61284 - Accountability Measures and Reduced Season for the South Atlantic Recreational Sector of Golden...

    Science.gov (United States)

    2011-10-04

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration 50 CFR Part 622 [Docket No. 0907271173-0629-03] RIN 0648-XA701 Accountability Measures and Reduced Season for the South Atlantic.... SUMMARY: NMFS implements accountability measures (AMs) for the recreational sector of golden tilefish in...

  5. Apixaban versus warfarin in patients with atrial fibrillation

    NARCIS (Netherlands)

    Granger, C.B.; Alexander, J.H.; McMurray, J.J.; Lopes, R.D.; Hylek, E.M.; Hanna, M.; Al-Khalidi, H.R.; Ansell, J.; Atar, D.; Avezum, A.; Bahit, M.C.; Diaz, R.; Easton, J.D.; Ezekowitz, J.A.; Flaker, G.; Garcia, D.; Geraldes, M.; Gersh, B.J.; Golitsyn, S.; Goto, S.; Hermosillo, A.G.; Hohnloser, S.H.; Horowitz, J.; Mohan, P.; Jansky, P.; Lewis, B.S.; Lopez-Sendon, J.L.; Pais, P.; Parkhomenko, A.; Verheugt, F.W.A.; Zhu, J.; Wallentin, L.

    2011-01-01

    BACKGROUND: Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations. Apixaban is a novel oral direct factor Xa inhibitor that has been shown to reduce the risk of stroke in a similar population in comparison with aspirin.

  6. Patrón tromboelastográfico en pacientes anticoagulados con rivaroxabán por fibrilación auricular

    Directory of Open Access Journals (Sweden)

    Susana Pacheco Jaramillo

    2016-11-01

    Conclusión: El patrón tromboelastográfico obtenido en la mayoría de pacientes del estudio se caracterizó por un tiempo de reacción alto y un índice de coagulación bajo, posiblemente debido al efecto del inhibidor del factor Xa.

  7. Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism

    NARCIS (Netherlands)

    Büller, Harry R.; Prins, Martin H.; Lensin, Anthonie W. A.; Decousus, Hervé; Jacobson, Barry F.; Minar, Erich; Chlumsky, Jaromir; Verhamme, Peter; Wells, Phil; Agnelli, Giancarlo; Cohen, Alexander; Berkowitz, Scott D.; Bounameaux, Henri; Davidson, Bruce L.; Misselwitz, Frank; Gallus, Alex S.; Raskob, Gary E.; Schellong, Sebastian; Segers, Annelise; Berkowitz, Scott; Gallus, Alexander; Lensing, Anthonie W. A.; Haskell, Lloyd; Raskob, Gary; Bauersachs, Rupert; van Bellen, Bonno; Boda, Zoltán; Borris, Lars; Brenner, Benjamin; Brighton, Tim; Davidson, Bruce; Decousus, Herve; Eriksson, Henry; Jacobson, Barry; Kakkar, Ajay; Kwong, Yok-Lam; Lee, Lai Heng; Meijer, Karina; van der Meer, Jan; Monreal, Manuel; Piovella, Franco; Sandset, Per Morten; Smith, Mark; Tomkowski, Witold; Wang, Yuqi; Brandjes, Dees; Mac Gillavry, Melvin; Otten, Hans-Martin; Carlsson, Anders; Kamphuisen, P.

    2012-01-01

    BACKGROUND A fixed-dose regimen of rivaroxaban, an oral factor Xa inhibitor, has been shown to be as effective as standard anticoagulant therapy for the treatment of deep-vein thrombosis, without the need for laboratory monitoring. This approach may also simplify the treatment of pulmonary embolism.

  8. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial

    DEFF Research Database (Denmark)

    Lassen, Michael Rud; Raskob, Gary E; Gallus, Alexander

    2010-01-01

    BACKGROUND: Low-molecular-weight heparins such as enoxaparin are preferred for prevention of venous thromboembolism after major joint replacement. Apixaban, an orally active factor Xa inhibitor, might be as effective, have lower bleeding risk, and be easier to use than is enoxaparin. We assessed ...

  9. Influences of the disease resistance conferred by the individual ...

    African Journals Online (AJOL)

    To research possible influences of the disease resistance conferred by different trans-resistance genes on the transgenic rice plants in their yields and grain quality, three transgenic rice lines, including two with the resistance genes Pi-d2 and Pi-d3, respectively, for rice blast, and one with the resistance gene Xa21 for rice ...

  10. 76 FR 5338 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2011-01-31

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA183 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... regulations (50 CFR parts 222-226) governing listed fish and wildlife permits. [[Page 5339

  11. 76 FR 5339 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2011-01-31

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA182 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... are issued in accordance with and are subject to the ESA and NMFS regulations governing listed fish...

  12. 77 FR 2037 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2012-01-13

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA928 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... advises the public that a direct take permit has been issued to the Washington Department of Fish and...

  13. 76 FR 6401 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2011-02-04

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA110 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... and the Washington Department of Fish and Wildlife submitted to NMFS, pursuant to the protective...

  14. 76 FR 64248 - Gulf of Mexico Reef Fish Fishery; Closure of the 2011 Gulf of Mexico Commercial Sector for...

    Science.gov (United States)

    2011-10-18

    .... 040205043-4043-01] RIN 0648-XA766 Gulf of Mexico Reef Fish Fishery; Closure of the 2011 Gulf of Mexico... the commercial sector for greater amberjack in the exclusive economic zone (EEZ) of the Gulf of Mexico... Reef Fish Resources of the Gulf of Mexico (FMP). The FMP was prepared by the Gulf of Mexico Fishery...

  15. 76 FR 53343 - Atlantic Highly Migratory Species; Commercial Porbeagle Shark Fishery Closure

    Science.gov (United States)

    2011-08-26

    ...-XA658 Atlantic Highly Migratory Species; Commercial Porbeagle Shark Fishery Closure AGENCY: National...: Temporary rule; fishery closure. SUMMARY: NMFS is closing the commercial fishery for porbeagle sharks. This... available quota. DATES: The commercial porbeagle shark fishery is closed effective 11:30 p.m. local time...

  16. 76 FR 17360 - Fisheries of the Exclusive Economic Zone Off Alaska; Octopus in the Bering Sea and Aleutian...

    Science.gov (United States)

    2011-03-29

    .... 101126521-0640-02] RIN 0648-XA322 Fisheries of the Exclusive Economic Zone Off Alaska; Octopus in the Bering... allowable catch of octopus in the Bering Sea and Aleutian Islands (BSAI). This action is necessary to allow... subpart H of 50 CFR part 600 and 50 CFR part 679. The 2011 initial total allowable catch (ITAC) of octopus...

  17. 76 FR 55276 - Fisheries of the Exclusive Economic Zone Off Alaska; Octopus in the Bering Sea and Aleutian Islands

    Science.gov (United States)

    2011-09-07

    .... 101126521-0640-02] RIN 0648-XA683 Fisheries of the Exclusive Economic Zone Off Alaska; Octopus in the Bering... retention of octopus in the Bering Sea and Aleutian Islands (BSAI). This action is necessary because the 2011 total allowable catch of octopus in the BSAI has been reached. DATES: Effective 1200 hrs, Alaska...

  18. Reflection and Non-Reflection of Particle Wavepackets

    Science.gov (United States)

    Cox, Timothy; Lekner, John

    2008-01-01

    Exact closed-form solutions of the time-dependent Schrodinger equation are obtained, describing the propagation of wavepackets in the neighbourhood of a potential. Examples given include zero reflection, total reflection and partial reflection of the wavepacket, for the sech[superscript 2]x/a, 1/x[superscript 2] and delta(x) potentials,…

  19. 75 FR 70714 - Global Free Flow of Information on the Internet

    Science.gov (United States)

    2010-11-18

    .... 100921457-0561-02] RIN 0660-XA20 Global Free Flow of Information on the Internet AGENCY: National... of comment period. SUMMARY: The Department of Commerce's Internet Policy Task Force announces that... on the global free flow of information on the Internet has been reopened and will extend until 5 p.m...

  20. 78 FR 36550 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Science.gov (United States)

    2013-06-18

    ... barriers to program implementation, solutions to those barriers, and documentation of client health... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [60Day-13-13XA... prescription filling patterns and timing of refills, checking for medication interactions, patient education...

  1. 76 FR 56742 - Mid-Atlantic Fishery Management Council; Workshop

    Science.gov (United States)

    2011-09-14

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA700 Mid-Atlantic... and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of a workshop. SUMMARY: The Eight..., economic and social perspectives. DATES: The workshop will be held Tuesday, October 4 through Thursday...

  2. 76 FR 71939 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-11-21

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA837 New England... Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New... Scientific and Statistical Committee (SSC) will discuss the 2012 SSC calendar and tasks, social science...

  3. 77 FR 2961 - Mid-Atlantic Fishery Management Council (MAFMC); Public Meeting

    Science.gov (United States)

    2012-01-20

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA943 Mid-Atlantic...), National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of a public meeting... with the Council's Social and Economic Sub-committee of the Scientific and Statistical Committee (SSC...

  4. 77 FR 5775 - Caribbean Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-02-06

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN: 0648-XA981 Caribbean... Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of public meeting. SUMMARY: The... --Bulletin/Newsletter --Social Network Pages --Streaming of Council Meetings --Other Business The meeting is...

  5. 76 FR 9553 - Mid-Atlantic Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-02-18

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA226 Mid-Atlantic... Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of public meeting. SUMMARY: The Social and Economic Sub-Committee of the Mid-Atlantic Fishery Management Council's (Council) Scientific...

  6. 76 FR 16620 - Mid-Atlantic Fishery Management Council (MAFMC); Meeting

    Science.gov (United States)

    2011-03-24

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA316 Mid-Atlantic... Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of public meeting. SUMMARY: The Social and Economic Sub-Committee of the Mid-Atlantic Fishery Management Council's (Council) Scientific...

  7. 76 FR 57958 - Fisheries of the South Atlantic and Gulf of Mexico; South Atlantic Fishery Management Council...

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN: 0648-XA708 Fisheries...), Commerce. ACTION: Notice of public meetings. SUMMARY: The South Atlantic Fishery Management Council (SAFMC...-pane reviews social and economic information and reports its findings to the SSC. The SEP will discuss...

  8. Federal Health Care Center: VA and DOD Need to Address Ongoing Difficulties and Better Prepare for Future Integrations

    Science.gov (United States)

    2016-02-01

    related documentation, performing data reliability checks (such as examining the data for missing values), and interviewing FHCC officials. After taking...and personnel Staffing, training, and the transfer of DOD civilian personnel to VA Xa Property Construction, transfer of property, and physical ...29For example, geriatric and mental health clinical areas were initially grouped with other

  9. 76 FR 65700 - Atlantic Highly Migratory Species; Advisory Panel for Atlantic Highly Migratory Species Southeast...

    Science.gov (United States)

    2011-10-24

    .... Virgin Islands and Puerto Rico, and each of the constituent interstate commissions: the Atlantic States... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA776 Atlantic Highly Migratory Species; Advisory Panel for Atlantic Highly Migratory Species Southeast Data, Assessment...

  10. 75 FR 74004 - Atlantic Highly Migratory Species; Advisory Panel

    Science.gov (United States)

    2010-11-30

    ... Atlantic Regional Fishery Management Councils, each of the 18 constituent states, both the U.S. Virgin... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA059 Atlantic... nominations for the Advisory Panel (AP) for Atlantic Highly Migratory Species (HMS) Southeast Data, Assessment...

  11. 76 FR 78242 - Endangered and Threatened Species; Take of Anadromous Fish

    Science.gov (United States)

    2011-12-16

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA866 Endangered and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... Endangered Species Act (ESA) and to help guide management and conservation efforts. The application may be...

  12. 76 FR 58471 - Endangered Species; File No. 15634

    Science.gov (United States)

    2011-09-21

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered..., [Responsible Party: Lisa Ballance, Ph.D.], has applied in due form for a permit to take leatherback sea turtles.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of...

  13. 77 FR 24686 - Endangered Species; File No. 15634

    Science.gov (United States)

    2012-04-25

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered... Ballance, Ph.D.] has been issued a permit to take leatherback sea turtles (Dermochelys coriacea) for... permit to take leatherback sea turtles had been submitted by the above-named organization. The requested...

  14. 77 FR 1062 - Endangered Species; File No. 16146

    Science.gov (United States)

    2012-01-09

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA900 Endangered... (Eretmochelys imbricata) sea turtles for the purposes of scientific research. ADDRESSES: The permit and related... take loggerhead, green, and hawksbill sea turtles had been submitted by the above-named individual. The...

  15. 75 FR 71670 - Endangered Species; File No. 15606

    Science.gov (United States)

    2010-11-24

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA054 Endangered... (Lepidochelys kempii), loggerhead (Caretta caretta), and hawksbill (Eretmochelys imbricata) sea turtles for... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as...

  16. 76 FR 22877 - Endangered Species; File No. 15566

    Science.gov (United States)

    2011-04-25

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA387 Endangered...), leatherback (Dermochelys coriacea), and hawksbill (Eretmochelys imbricata) sea turtles for purposes of... Federal Register (75 FR 67682) that a request for a scientific research permit to take sea turtles had...

  17. 76 FR 37327 - Endangered Species; File No. 16253

    Science.gov (United States)

    2011-06-27

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA518 Endangered... loggerhead (Caretta caretta) sea turtles for scientific research. DATES: Written, telefaxed, or e-mail... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as...

  18. 77 FR 1671 - Endangered Species; File No. 16194

    Science.gov (United States)

    2012-01-11

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA925 Endangered... olivacea), leatherback (Dermochelys coriacea), and unidentified hardshell sea turtles for the purposes of..., leatherback, Kemp's ridley, olive ridley, and unidentified hardshell sea turtles had been submitted by the...

  19. 76 FR 71515 - Endangered Species; File No. 16174

    Science.gov (United States)

    2011-11-18

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA826 Endangered... issued a permit to take green sea turtles (Chelonia mydas) for the purposes of scientific research... request for a scientific research permit to take green sea turtles had been submitted by the above-named...

  20. 76 FR 33245 - Endangered Species; File No. 15135

    Science.gov (United States)

    2011-06-08

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA466 Endangered..., 132 Conch Court, Emerald Isle, NC 28594, has been issued a permit to take threatened and endangered sea turtles for purposes scientific research. ADDRESSES: The permit and related documents are...