WorldWideScience

Sample records for bid rigging

  1. Essays on bid rigging

    NARCIS (Netherlands)

    Seres, Gyula

    2016-01-01

    Manipulating prices in auctions raises antitrust concerns. Collusion lowers the revenue of the auctioneer and creates information rents. Bid rigging is a prevalent phenomenon and the affected market is enormous. Public procurement amounts to between 10 and 25 percent of national GDP in industrialize

  2. An Examination of Criminalization of Russia’s Anti-Bid Rigging Policy

    Directory of Open Access Journals (Sweden)

    Natalya Mosunova

    2015-01-01

    Full Text Available The paper investigates enforcement of criminal sanctions in anti-bid rigging policy in Russia. Although cartels were criminalized in 1997, parties of numerous anticompetitive agreements on tenders are punished by corporate or individual fines, or disqualified. Statistics on sentences for bid rigging are highly controversial although legislative conditions for efficient criminalization are presented not only by criminal norms but also by leniency programmes in administrative and criminal proceedings which were designed to contribute to anticartel enforcement.The aim of this research is to determine factors that have caused the very rare use of criminal sanctions for cartel enforcement with the focus on bid rigging. For the purpose of the research, the paper outlines the regulation of tendering in Russia and the system of sanctions for bid rigging, including leniency. Case analysis of the first custodial sentence for anticompetitive agreement on a public tender highlights specific features resulting in successful prosecution. Since this is one of the first attempts to assess criminalization of bid rigging in Russia, original empirical data including interviews with officials from federal competition authorities and regional representatives constitute the basis of the study.Findings of the research determine the influence of social norms on the enforcement as the main challenge for criminalization of bid rigging which is weighed down by the insufficient political influence of competition authorities. The paper’s findings may be of interest for assessing enforcement in other jurisdictions experiencing the same difficulties.

  3. Rig it right! Maya animation rigging concepts

    CERN Document Server

    O'Hailey, Tina

    2013-01-01

    Rigging a character can be a complicated undertaking. Move from a bi-pedal character to a quad- or poly-pedal and, well, things just got real. Where do you begin? Unlike all of those button-pushing manuals out there, Rig it Right! breaks down rigging so that you can achieve a fundamental understanding of the concept, allowing you to rig more intuitively in your own work. Veteran animation professor Tina O'Hailey will get you up and rigging in a matter of hours with step-by-step tutorials covering multiple animation control types, connection methods, interactive skinning, Blend

  4. The art of rigging

    CERN Document Server

    Biddlecombe, George

    1990-01-01

    The best manual ever produced on rigging a sailing ship, based on extensively revised and updated 1848 edition prepared by Biddlecombe, Master in the Royal Navy. Complete definition of terms, on-shore operations, process of rigging ships, reeving the running rigging and bending sails, rigging brigs, yachts and small vessels, more. 17 plates.

  5. What Really Rigs Up RIG-I?

    Science.gov (United States)

    Barik, Sailen

    2016-01-01

    RIG-I (retinoic acid-inducible gene 1) is an archetypal member of the cytoplasmic DEAD-box dsRNA helicase family (RIG-I-like receptors or RLRs), the members of which play essential roles in the innate immune response of the metazoan cell. RIG-I functions as a pattern recognition receptor that detects nonself RNA as a pathogen-associated molecular pattern (PAMP). However, the exact molecular nature of the viral RNAs that act as a RIG-I ligand has remained a mystery and a matter of debate. In this article, we offer a critical review of the actual viral RNAs that act as PAMPs to activate RIG-I, as seen from the perspective of a virologist, including a recent report that the viral Leader-read-through transcript is a novel and effective RIG-I ligand.

  6. Mergers in Bidding Markets

    NARCIS (Netherlands)

    M.C.W. Janssen (Maarten); V.A. Karamychev (Vladimir)

    2013-01-01

    textabstractWe analyze the effects of mergers in first-price sealed-bid auctions on bidders' equilibrium bidding functions and on revenue. We also study the incentives of bidders to merge given the private information they have. We develop two models, depending on how after-merger valuations are cre

  7. Heisenberg model and Rigged Configurations

    CERN Document Server

    Giri, Pulak Ranjan

    2015-01-01

    We show a correspondence of all the solutions of the spin-1/2 isotropic Heisenberg model for N=12 to the rigged configurations based on the comparison of the set of Takahashi quantum numbers in lexicographical order with the set of riggings of the rigged configurations in co-lexicographical order.

  8. DMEPOS Competitive Bidding

    Data.gov (United States)

    U.S. Department of Health & Human Services — The DMEPOS Competitive Bidding Program was mandated by Congress through the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA). The statute...

  9. The BID`s of New York

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    The aim of this paper is to analyse selected examples of Business Improvement Districts on Manhatten, NYC in order to uncover how this sort of urban interventions shapes the physical urban space as well as the image and representation of that particular space. In the first part of the paper, the ....... In the third part of the paper empirical field data from selected New York BIDs are presented. Finally the paper ends with a section in which concluding remarks will be accompanied by reflections on the comparative similarities and differences to European cities....

  10. Bidding for Concessions Bidding for Concessions

    Directory of Open Access Journals (Sweden)

    Michael Klein

    1998-03-01

    Full Text Available Privatization of infrastructure ventures in sectors such as energy, telecommunications, transport and water has become popular over the last decade. Often –for good or bad reasons- private firms are given monopoly franchises under some type of long-term concession agreement, for example "Build-Operate-Transfer" schemes. The article surveys the issues arising in designing concession contracts and in awarding them to private parties. It is crucial to define performance specifications as well as incentive and risk-sharing parameters comprehensively and consistently both to achieve efficient performance by the concessionaire and to minimize post-award re-negotiation. Concession award should as a rule be made competitively, unless special requirements of speed, innovation or excessive transaction costs argue otherwise. Typically, competitive concession award is made by first price sealed bids. There are strong arguments, however, to consider open auctions more seriously in a number of cases. Auctions may also be re-awarded by way of auction. However, somewhat arbitrary bid preferences may have to be set. Auctioneers for complex concession contracts should operate at arms-length for all interested parties, including politicians. It may be sensible to let independent agencies that regulate the concession scheme run the auction. Privatization of infrastructure ventures in sectors such as energy, telecommunications, transport and water has become popular over the last decade. Often –for good or bad reasons- private firms are given monopoly franchises under some type of long-term concession agreement, for example "Build-Operate-Transfer" schemes. The article surveys the issues arising in designing concession contracts and in awarding them to private parties. It is crucial to define performance specifications as well as incentive and risk-sharing parameters comprehensively and consistently both to achieve efficient performance by the concessionaire and

  11. Pressure rig for repetitive casting

    Science.gov (United States)

    Vasquez, Peter (Inventor); Hutto, William R. (Inventor); Philips, Albert R. (Inventor)

    1989-01-01

    The invention is a pressure rig for repetitive casting of metal. The pressure rig performs like a piston for feeding molten metal into a mold. Pressure is applied to an expandable rubber diaphragm which expands like a balloon to force the metal into the mold. A ceramic cavity which holds molten metal is lined with blanket-type insulating material, necessitating only a relining for subsequent use and eliminating the lengthy cavity preparation inherent in previous rigs. In addition, the expandable rubber diaphragm is protected by the insulating material thereby decreasing its vulnerability to heat damage. As a result of the improved design the life expectancy of the pressure rig contemplated by the present invention is more than doubled. Moreover, the improved heat protection has allowed the casting of brass and other alloys with higher melting temperatures than possible in the conventional pressure rigs.

  12. Hoisting and Rigging (Formerly Hoisting and Rigging Manual)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This standard is intended as a reference document to be used by supervisors, line managers, safety personnel, equipment operators, and any other personnel responsible for safety of hoisting and rigging operations at DOE sites. It quotes or paraphrases the US OSHA and ANSI requirements. It also encompasses, under one cover,hoisting and rigging requirements, codes, standards, and regulations, eliminating the need to maintain extensive (and often incomplete) libraries of hoisting and rigging standards throughout DOE. The standard occasionally goes beyond the minimum general industry standards established by OSHA and ANSI, and also delineates the more stringent requirements necessary to accomplish the complex, diversified, critical, and often hazardous hoisting and rigging work found with the DOE complex.

  13. Optimal GENCO bidding strategy

    Science.gov (United States)

    Gao, Feng

    Electricity industries worldwide are undergoing a period of profound upheaval. The conventional vertically integrated mechanism is being replaced by a competitive market environment. Generation companies have incentives to apply novel technologies to lower production costs, for example: Combined Cycle units. Economic dispatch with Combined Cycle units becomes a non-convex optimization problem, which is difficult if not impossible to solve by conventional methods. Several techniques are proposed here: Mixed Integer Linear Programming, a hybrid method, as well as Evolutionary Algorithms. Evolutionary Algorithms share a common mechanism, stochastic searching per generation. The stochastic property makes evolutionary algorithms robust and adaptive enough to solve a non-convex optimization problem. This research implements GA, EP, and PS algorithms for economic dispatch with Combined Cycle units, and makes a comparison with classical Mixed Integer Linear Programming. The electricity market equilibrium model not only helps Independent System Operator/Regulator analyze market performance and market power, but also provides Market Participants the ability to build optimal bidding strategies based on Microeconomics analysis. Supply Function Equilibrium (SFE) is attractive compared to traditional models. This research identifies a proper SFE model, which can be applied to a multiple period situation. The equilibrium condition using discrete time optimal control is then developed for fuel resource constraints. Finally, the research discusses the issues of multiple equilibria and mixed strategies, which are caused by the transmission network. Additionally, an advantage of the proposed model for merchant transmission planning is discussed. A market simulator is a valuable training and evaluation tool to assist sellers, buyers, and regulators to understand market performance and make better decisions. A traditional optimization model may not be enough to consider the distributed

  14. Argentina's YPF outlines plan for sale of rigs

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-16

    This paper reports that state owned Yacimientos Petroliferos Fiscales (YPF) has unveiled the schedule it plans to follow to privatize oil and gas contract drilling in Argentine. YPF proposes to exit the drilling business by selling state owned drilling rigs, drill pipe, and accessories in a series of auctions beginning next month and lasting through first quarter 1993. YPF intends to open bids Dec. 16 for a completion unit and 30 drilling rigs, several working under contract. Bids will be opened during first quarter 1993 for new and used YPF drill pipe and collars, spare equipment and accessories, and an inventory of fishing tools said to be one of the largest in South America. Winners are to be notified immediately after each auction. YPF plans to hand over by Feb. 1, 1993, the rigs sold in December. Companies buying YPF drilling assets in first quarter 1993, the rigs sold in December. Companies buying YPF drilling assets in first quarter 1993 are to assume ownership by Mar. 24, 1993.

  15. Information Feedback and Learning in Construction Bidding

    Directory of Open Access Journals (Sweden)

    Bee Lan Oo

    2011-09-01

    Full Text Available Information feedback condition in recurrent construction bidding is an important design variable about optimal procurement design. Contractors tend to optimize their bids in recurrent bidding with positive review of historic bids. Our experiment examines the effects of partial and no information feedback conditions on student (inexperienced bidders’ bidding trends, and the extent to which their bidding trends agree with the behavioural patterns proposed by learning direction theory. The results show that the variations in bids over time for both information feedback conditions are statistically significant. Although the bidders with partial bidding feedback information are more likely to vary their bids as indicated by learning direction theory, their bids are less competitive than those with no bidding feedback information. Construction clients would need to consider the information feedback conditions in their procurement of construction services with the goal to achieve efficiency in construction bidding.

  16. A Model for Contract Bid Markup Strategies

    Institute of Scientific and Technical Information of China (English)

    LI Yong-ping; CHEN Rong-qiu; ZHOU Shao-fu

    2001-01-01

    This paper presents a bid model which can be readily implemented in a competitive bid environment within the construction industry. Competitive bid situations involve a multiplicity of criteria. In this paper, 31 criteria, which effect optimum estimation, are considered. The model is based on CBR, the database of past completed bids, and information associated with successful bids. CBR is considered the best method because of the complexity of the construction domain and the wealth of information that the contractors possessed on past bids.

  17. PNNL Hoisting and Rigging Manual

    Energy Technology Data Exchange (ETDEWEB)

    Haynie, Todd O.; Fullmer, Michael W.

    2008-12-29

    This manual describes the safe and cost effective operation, inspection, maintenance, and repair requirements for cranes, hoists, fork trucks, slings, rigging hardware, and hoisting equipment. It is intended to be a user's guide to requirements, codes, laws, regulations, standards, and practices that apply to Pacific Northwest National Laboratory (PNNL) and its subcontractors.

  18. Rigged Hilbert spaces for chaotic dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    Suchanecki, Z. [International Solvay Institutes for Physics and Chemistry, CP 231, Campus Plaine ULB, Bd. du Triomphe, 1050 Brussels (Belgium)]|[Hugo Steinhaus Center and Institute of Mathematics, Wrocl/aw Technical University, ul. Wybrzeze Wyspianskiego 27, 50-370 Wroclaw (Poland); Antoniou, I. [International Solvay Institutes for Physics and Chemistry, CP 231, Campus Plaine ULB, Bd. du Triomphe, 1050 Brussels (Belgium)]|[Theoretische Natuurkunde Free University of Brussels; Tasaki, S. [International Solvay Institutes for Physics and Chemistry, CP 231, Campus Plaine ULB, Bd. du Triomphe, 1050 Brussels, Belgium and]|[Institute for Fundamental Chemistry 34-4 Takano Nishihiraki-cho Kyoto 606 (Japan); Bandtlow, O.F. [International Solvay Institutes for Physics and Chemistry, CP 231, Campus Plaine ULB, Bd. du Triomphe, 1050 Brussels (Belgium)]|[Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB30HE (United Kingdom)

    1996-11-01

    We consider the problem of rigging for the Koopman operators of the Renyi and the baker maps. We show that the rigged Hilbert space for the Renyi maps has some of the properties of a strict inductive limit and give a detailed description of the rigged Hilbert space for the baker maps. {copyright} {ital 1996 American Institute of Physics.}

  19. Hoisting and rigging manual: Uncontrolled document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-05-01

    This document is a draft copy of a Hoisting and Rigging Manual for the Department of Energy. The manual is divided into ten chapters. The chapter titles follow: terminology and definitions; operator training and qualification; overhead and gantry cranes; mobile cranes; forklift trucks; hoists; hooks; wire rope, slings, and rigging accessories; construction hoisting and rigging equipment requirements; references.

  20. Rotary Engine Friction Test Rig Development Report

    Science.gov (United States)

    2011-12-01

    5  4.  Friction Rig Development 7  5.  AutoCAD ...Figure 4. Engine friction test rig AutoCAD model. ........................................................................8  Figure 5. Engine...top dead center. 8 5. AutoCAD Model Development A model of the rotary engine friction test rig was developed to determine the optimal

  1. 36 CFR 223.231 - Bidding methods.

    Science.gov (United States)

    2010-07-01

    ...) Ensure open and fair competition; (b) Ensure that the Federal Government receives minimum rates or... prospectus. The Forest Service shall not accept a bid at oral auction that is less than the bidder's initial sealed bid; and (e) Specify the use of sealed bids or a mix of bidding methods in the affected area...

  2. 24 CFR 291.304 - Bidding process.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Bidding process. 291.304 Section 291.304 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Family Mortgage Loans § 291.304 Bidding process. (a) Submission of bids. All bids must be submitted...

  3. 29 CFR 1918.54 - Rigging gear.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Rigging gear. 1918.54 Section 1918.54 Labor Regulations...) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Vessel's Cargo Handling Gear § 1918.54 Rigging gear. (a... other alternate device shall be provided to allow trimming of the gear and to prevent employees...

  4. 40 CFR 73.71 - Bidding.

    Science.gov (United States)

    2010-07-01

    ... using the Bid Form for SO2 Allowance Auctions, or some method of electronic transfer if the Administrator, following public notice, so requires or permits at some future time. The bid form shall state: (1... Representative Form must accompany the bid. New account information shall include at a minimum: Name,...

  5. 42 CFR 414.910 - Bidding process.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Bidding process. 414.910 Section 414.910 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Under Part B § 414.910 Bidding process. (a) Entities may bid to furnish CAP drugs in all...

  6. China-made Rigs Enter International Market

    Institute of Scientific and Technical Information of China (English)

    Zhang Yongze; Chen Liren

    2006-01-01

    @@ Nowadays, China's drilling equipment manufacturing has formed into a sophisticated industrial chain, playing an indispensable role in supporting China's petroleum industry. Especially in recent years, apart from satisfying the requirements of domestic onshore drilling operations,the state-of-the-art drilling equipments like offshore modular drilling rigs, 9000 meter ultra-deep rigs have also been successfully manufactured, this, together with the wholesale export of electric drilling rigs to the overseas market, has ranked China as a primary manufacturer of drilling equipments in the world. China can now wholesale produce series of onshore and offshore drilling equipment with rig production of nearly 200 per year.The production capacity accounts for 20%-25% of the world total. In addition to satisfying domestic market,China made onshore drilling rigs have also gained great competitive advantages in the international market.

  7. Takeover bids and insider trading

    NARCIS (Netherlands)

    Nelemans, Matthijs; Bainbridge, Stephen M.

    2014-01-01

    This paper analyses the law and economics of insider trading in the context of takeover bids, focusing on the European regulatory framework. We distinguish between trading by the bidder, by the target and by classical insiders and first address the issue of precisely when information about potential

  8. 38th annual Reed rig census

    Energy Technology Data Exchange (ETDEWEB)

    Fitts, R.L.; Crowhurst, M.E. (Market Research and Analysis, Reed Tool Co., Houston, TX (US))

    1990-10-01

    According to this report, sharp and encouraging movement toward a balance between rig supply and demand is becoming apparent. During the past year, contractors reported the number of rigs available for drilling in the U.S. fell by 222 (8.7%). Contractors also reported that rigs meeting the census definition of active increased by 233 (16.1%). Highlights of the 1990 census, presented by the authors, include: The available U.S. fleet now stands at 2,320 rigs, the lowest since 1976. Last year's count was 2,542. The census active count of 1,677 rigs is the highest since 1985 and up from 1,444 last year. Rig utilization increased to 72%, up from the 57% a year ago. The number of rig owners declined from 558 to 500. More than 190 companies have left the drilling business since 1987. About 6.5% of last year's fleet was cannibalized or auctioned as parts.

  9. Body Language Advanced 3D Character Rigging

    CERN Document Server

    Allen, Eric; Fong, Jared; Sidwell, Adam G

    2011-01-01

    Whether you're a professional Character TD or just like to create 3D characters, this detailed guide reveals the techniques you need to create sophisticated 3D character rigs that range from basic to breathtaking. Packed with step-by-step instructions and full-color illustrations, Body Language walks you through rigging techniques for all the body parts to help you create realistic and believable movements in every character you design. You'll learn advanced rigging concepts that involve MEL scripting and advanced deformation techniques and even how to set up a character pipeline.

  10. Learning Inverse Rig Mappings by Nonlinear Regression.

    Science.gov (United States)

    Holden, Daniel; Saito, Jun; Komura, Taku

    2016-11-11

    We present a framework to design inverse rig-functions - functions that map low level representations of a character's pose such as joint positions or surface geometry to the representation used by animators called the animation rig. Animators design scenes using an animation rig, a framework widely adopted in animation production which allows animators to design character poses and geometry via intuitive parameters and interfaces. Yet most state-of-the-art computer animation techniques control characters through raw, low level representations such as joint angles, joint positions, or vertex coordinates. This difference often stops the adoption of state-of-the-art techniques in animation production. Our framework solves this issue by learning a mapping between the low level representations of the pose and the animation rig. We use nonlinear regression techniques, learning from example animation sequences designed by the animators. When new motions are provided in the skeleton space, the learned mapping is used to estimate the rig controls that reproduce such a motion. We introduce two nonlinear functions for producing such a mapping: Gaussian process regression and feedforward neural networks. The appropriate solution depends on the nature of the rig and the amount of data available for training. We show our framework applied to various examples including articulated biped characters, quadruped characters, facial animation rigs, and deformable characters. With our system, animators have the freedom to apply any motion synthesis algorithm to arbitrary rigging and animation pipelines for immediate editing. This greatly improves the productivity of 3D animation, while retaining the flexibility and creativity of artistic input.

  11. Competitive bidding in Medicare Advantage: effect of benchmark changes on plan bids.

    Science.gov (United States)

    Song, Zirui; Landrum, Mary Beth; Chernew, Michael E

    2013-12-01

    Bidding has been proposed to replace or complement the administered prices that Medicare pays to hospitals and health plans. In 2006, the Medicare Advantage program implemented a competitive bidding system to determine plan payments. In perfectly competitive models, plans bid their costs and thus bids are insensitive to the benchmark. Under many other models of competition, bids respond to changes in the benchmark. We conceptualize the bidding system and use an instrumental variable approach to study the effect of benchmark changes on bids. We use 2006-2010 plan payment data from the Centers for Medicare and Medicaid Services, published county benchmarks, actual realized fee-for-service costs, and Medicare Advantage enrollment. We find that a $1 increase in the benchmark leads to about a $0.53 increase in bids, suggesting that plans in the Medicare Advantage market have meaningful market power.

  12. 48 CFR 14.202-1 - Bidding time.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Bidding time. 14.202-1... AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 14.202-1 Bidding time. (a) Policy. A reasonable time for prospective bidders to prepare and submit bids shall be allowed in all invitations,...

  13. Impact of Contractors’ Bidding Strategies on Bid Success in the Nigeria Construction Industry

    Directory of Open Access Journals (Sweden)

    Tolulope Samuel Fawale

    2017-01-01

    Full Text Available Several types of researches have been carried out prior to the new millennium on the subject of bidding strategies in the construction industry. Today, organizations are faced with a very complex decision of bid/no-bid because it requires the assessment of large number of highly inter-related variables. The study aims at examining different types of Contractors’ Bidding Strategies (CBS with a view to determining their impact on bid success. In line with the aim, the study objectives include; evaluation of different types of CBS and; assessment of the success rate of contractors’ bid. The method of approach elicits information on the number of projects bided and successes recorded over a period of time. A total of one hundred and seventy-one useable responses were retrieved from questionnaire administration. Descriptive statistics, tables and percentages as well as mean item score (MIS were used for data analysis. The study showed that lowest bid, public relations and joint venture bidding strategies have great impact on contractors’ bid success especially on residential, educational and administrative projects in the Nigeria Construction Industry (NCI. Therefore, the study concluded that relationship exists between contractors’ bidding strategies and equivalent successes recorded over a period of time. It is important to also know that lowest bid strategy still remains the most effective bidding strategy for public works contracting in the NCI.

  14. An experimental study of precautionary bidding

    NARCIS (Netherlands)

    Kocher, M.G.; Pahlke, J.; Trautmann, S.T.

    2015-01-01

    Auctions often involve goods exhibiting a common-knowledge ex-post risk. In such auctions, precautionary bidding predicts that under expected utility, DARA bidders reduce their bids by more than the appropriate risk premium. Because the degree of riskiness of an auctioned good and bidders’ levels of

  15. Rent seeking with efforts and bids

    NARCIS (Netherlands)

    Haan, M.A.; Schoonbeek, L.

    2003-01-01

    We introduce bids in a rent-seeking contest. Players compete for a prize. Apart from exerting lobbying efforts, they also submit a bid which is payable only if they win the prize. We show that our model has a unique Nash equilibrium in pure strategies, in which each active player submits the same bi

  16. Optical Micro- and Nanofiber Pulling Rig

    CERN Document Server

    Ward, J M; Le, Vu H; Chormaic, S Nic

    2014-01-01

    We review the method of producing adiabatic optical micro- and nanofibers using a hydrogen/oxygen flame brushing technique. The flame is scanned along the fiber, which is being simultaneously stretched by two translation stages. The tapered fiber fabrication is reproducible and yields highly adiabatic tapers with either exponential or linear profiles. Details regarding the setup of the flame brushing rig and the various parameters used are presented. Information available from the literature is compiled and further details that are necessary to have a functioning pulling rig are included. This should enable the reader to fabricate various taper profiles, while achieving adiabatic transmission of ~ 99% for fundamental mode propagation. Using this rig, transmissions greater than 90% for higher order modes in an optical nanofiber have been obtained.

  17. Design and Characterization of a Centrifugal Compressor Surge Test Rig

    OpenAIRE

    2011-01-01

    A detailed description of a new centrifugal compressor surge test rig is presented. The objective of the design and development of the rig is to study the surge phenomenon in centrifugal compression systems and to investigate a novel method of surge control by active magnetic bearing servo actuation of the impeller axial tip clearance. In this paper, we focus on the design, initial setup, and testing of the rig. The latter two include the commissioning of the rig and the experimental characte...

  18. Status of the Combined Cycle Engine Rig

    Science.gov (United States)

    Saunders, Dave; Slater, John; Dippold, Vance

    2009-01-01

    Status for the past year is provided of the turbine-based Combined-Cycle Engine (CCE) Rig for the hypersonic project. As part of the first stage propulsion of a two-stage-to-orbit vehicle concept, this engine rig is designed with a common inlet that supplies flow to a turbine engine and a dual-mode ramjet / scramjet engine in an over/under configuration. At Mach 4 the inlet has variable geometry to switch the airflow from the turbine to the ramjet / scramjet engine. This process is known as inlet mode-transition. In addition to investigating inlet aspects of mode transition, the rig will allow testing of turbine and scramjet systems later in the test series. Fully closing the splitter cowl "cocoons" the turbine engine and increases airflow to the scramjet duct. The CCE Rig will be a testbed to investigate integrated propulsion system and controls technology objectives. Four phases of testing are planned to 1) characterize the dual inlet database, 2) collect inlet dynamics using system identification techniques, 3) implement an inlet control to demonstrate mode-transition scenarios and 4) demonstrate integrated inlet/turbine engine operation through mode-transition. Status of the test planning and preparation activities is summarized with background on the inlet design and small-scale testing, analytical CFD predictions and some details of the large-scale hardware. The final stages of fabrication are underway.

  19. Deep water challenges for drilling rig design

    Energy Technology Data Exchange (ETDEWEB)

    Roth, M. [Transocean Sedco Forex, Houston, TX (United States)

    2001-07-01

    Drilling rigs designed for deep water must meet specific design considerations for harsh environments. The early lessons for rig design came from experiences in the North Sea. Rig efficiency and safety considerations must include structural integrity, isolated/redundant ballast controls, triple redundant DP systems, enclosed heated work spaces, and automated equipment such as bridge cranes, pipe handling gear, offline capabilities, subsea tree handling, and computerized drill floors. All components must be designed to harmonize man and machine. Some challenges which are unique to Eastern Canada include frequent storms and fog, cold temperature, icebergs, rig ice, and difficult logistics. This power point presentation described station keeping and mooring issues in terms of dynamic positioning issues. The environmental influence on riser management during forced disconnects was also described. Design issues for connected deep water risers must insure elastic stability, and control deflected shape. The design must also keep stresses within acceptable limits. Codes and standards for stress limits, flex joints and tension were also presented. tabs., figs.

  20. Largest Contract for Rig Export Wound up Successfully

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    @@ In mid-November, the last drilling rig, typed ZJ50DBA,of the 10-rig deal was packed and transported to Uzbekistan from Chuanyou Guanghan Honghua Co Ltd, a drilling equipment producer under Sichuan Petroleum Administration Bureau, putting an end to China's largest contract for export of drilling rigs.

  1. Marginal Bidding: An Application of the Equimarginal Principle to Bidding in TAC SCM

    Science.gov (United States)

    Greenwald, Amy; Naroditskiy, Victor; Odean, Tyler; Ramirez, Mauricio; Sodomka, Eric; Zimmerman, Joe; Cutler, Clark

    We present a fast and effective bidding strategy for the Trading Agent Competition in Supply Chain Management (TAC SCM). In TAC SCM, manufacturers compete to procure computer parts from suppliers (the procurement problem), and then sell assembled computers to customers in reverse auctions (the bidding problem). This paper is concerned only with bidding, in which an agent must decide how many computers to sell and at what prices to sell them. We propose a greedy solution, Marginal Bidding, inspired by the Equimarginal Principle, which states that revenue is maximized among possible uses of a resource when the return on the last unit of the resource is the same across all areas of use. We show experimentally that certain variations of Marginal Bidding can compute bids faster than our ILP solution, which enables Marginal Bidders to consider future demand as well as current demand, and hence achieve greater revenues when knowledge of the future is valuable.

  2. Bid distribution derived from consistent mixed strategy in lowest unique bid auction

    Science.gov (United States)

    Zhao, Yinan; Chen, Qinghua; Wang, Yougui

    2014-12-01

    The Lowest Unique Bid Auction (LUBA) booms recently through the Internet. A typical distribution pattern of bid price in this reverse auction has been found and needs to be interpreted. The distribution curve is a decreasing one whose slope has a close relationship with the number of agents participating in the auction. To explain this stylized fact, we develop a model assuming that agents prefer to bid on the price at which the probability of winning is higher. The bid distributions of actual auctions with the number of agents less than 200 can be fitted very well using the parameters for the value of items and the number of bids. When this number becomes larger, however, a deviation occurs between prediction and empirical data, which can be adjusted by introducing cognitive illusion of the bid number.

  3. 48 CFR 14.404-2 - Rejection of individual bids.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Rejection of individual... of individual bids. (a) Any bid that fails to conform to the essential requirements of the invitation... total price of the bid, but the prices for individual line items as well. (g) Any bid may be rejected...

  4. Bid Regulations in a Multi-unit Uniform Price Auction

    DEFF Research Database (Denmark)

    Boom, Anette

    for larger rms does not guarantee market prices below that cap. A suffciently high bid floor only for smaller firms destroys some or all pure strategy equilibria despite their prices being above the bid floor. With a general bid floor this happens only with considerably higher bid floors.......This paper examines the effect of bid regulations on the range of potential equilibrium prices in a multi-unit uniform price auction with heterogenous bidders. General bid caps destroy equilibria with prices above the bid cap and create new equilibria with prices way below the cap. A cap only...

  5. Political entrepreneurship and bidding for political monopoly

    OpenAIRE

    Michael Wohlgemuth

    2000-01-01

    An analytical framework for dealing with political entrepreneurship and reform is proposed which is based on some new combinations of Schumpeterian political economy, an extended version of Tullock's model of democracy as franchise-bidding for natural monopoly and some basic elements of New Institutional Economics. It is shown that problems of insufficient award criteria and incomplete contracts which may arise in economic bidding schemes, also - and even more so - characterise political comp...

  6. Europe wrestles with ITER site bid

    CERN Multimedia

    Feder, T

    2003-01-01

    "The European Union is in a quandary over whether to put forward the French or Spanish site to host ITER, a $5 billion magnetic fusion experiment intended to prove the feasability of fusion energy. The decision is set for 27 November, with the final site selection, between the victorious European bid and bids from Canada and Japan, to follow within a couple of months" (1 page)

  7. Minimizing forced outage risk in generator bidding

    Science.gov (United States)

    Das, Dibyendu

    Competition in power markets has exposed the participating companies to physical and financial uncertainties. Generator companies bid to supply power in a day-ahead market. Once their bids are accepted by the ISO they are bound to supply power. A random outage after acceptance of bids forces a generator to buy power from the expensive real-time hourly spot market and sell to the ISO at the set day-ahead market clearing price, incurring losses. A risk management technique is developed to assess this financial risk associated with forced outages of generators and then minimize it. This work presents a risk assessment module which measures the financial risk of generators bidding in an open market for different bidding scenarios. The day-ahead power market auction is modeled using a Unit Commitment algorithm and a combination of Normal and Cauchy distributions generate the real time hourly spot market. Risk profiles are derived and VaRs are calculated at 98 percent confidence level as a measure of financial risk. Risk Profiles and VaRs help the generators to analyze the forced outage risk and different factors affecting it. The VaRs and the estimated total earning for different bidding scenarios are used to develop a risk minimization module. This module will develop a bidding strategy of the generator company such that its estimated total earning is maximized keeping the VaR below a tolerable limit. This general framework of a risk management technique for the generating companies bidding in competitive day-ahead market can also help them in decisions related to building new generators.

  8. Bethe's quantum numbers and rigged configurations

    Directory of Open Access Journals (Sweden)

    Anatol N. Kirillov

    2016-04-01

    Full Text Available We propose a method to determine the quantum numbers, which we call the rigged configurations, for the solutions to the Bethe ansatz equations for the spin-1/2 isotropic Heisenberg model under the periodic boundary condition. Our method is based on the observation that the sums of Bethe's quantum numbers within each string behave particularly nicely. We confirm our procedure for all solutions for length 12 chain (totally 923 solutions.

  9. Glenn Extreme Environments Rig (GEER) Independent Review

    Science.gov (United States)

    Jankovsky, Robert S.; Smiles, Michael D.; George, Mark A.; Ton, Mimi C.; Le, Son K.

    2015-01-01

    The Chief of the Space Science Project Office at Glenn Research Center (GRC) requested support from the NASA Engineering and Safety Center (NESC) to satisfy a request from the Science Mission Directorate (SMD) Associate Administrator and the Planetary Science Division Chief to obtain an independent review of the Glenn Extreme Environments Rig (GEER) and the operational controls in place for mitigating any hazard associated with its operation. This document contains the outcome of the NESC assessment.

  10. Development of Magnetorheological Engine Mount Test Rig

    OpenAIRE

    Md Yunos Mohd Razali; Harun Mohamad Hafiz; Sariman M.Z.; Mat Yamin A.K.

    2017-01-01

    Ride comfort is an important factor in any road vehicle performance. Nonetheless, passenger ride comfort is sometimes affected by the vibrations resulting from the road irregularities. Vehicle ride comfort is also often compromised by engine vibration. Engine mount is one of the devices which act as vibration isolator from unwanted vibration from engine to the driver and passengers. This paper explains the development of the test rig used for laboratory testing of Magnetorheological (MR) engi...

  11. Computers make rig life extension an option

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The worldwide semisubmersible drilling rig fleet is approaching retirement. But replacement is not an attractive option even though dayrates are reaching record highs. In 1991, Schlumberger Sedco Forex managers decided that an alternative might exist if regulators and insurers could be convinced to extend rig life expectancy through restoration. Sedco Forex chose their No. 704 semisubmersible, an 18-year North Sea veteran, to test their process. The first step was to determine what required restoration, meaning fatigue life analysis of each weld on the huge vessel. If inspected, the task would be unacceptably time-consuming and of questionable accuracy. Instead a suite of computer programs modeled the stress seen by each weld, statistically estimated the sea states seen by the rig throughout its North Sea service and calibrated a beam-element model on which to run their computer simulations. The elastic stiffness of the structure and detailed stress analysis of each weld was performed with ANSYS, a commercially available finite-element analysis program. The use of computer codes to evaluate service life extension is described.

  12. Bidding strategy in pay-as-bid markets based on supplier-market interaction analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bigdeli, N., E-mail: bigdeli@ee.sharif.ed [EE Department, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of); Afshar, K., E-mail: k_afshar@ee.sharif.ed [EE Department, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of); Fotuhi-Firuzabad, M., E-mail: fotuhi@sharif.ed [EE Department, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

    2010-12-15

    In this paper, a new bidding strategy for pay-as-bid market suppliers is introduced. This method is based on a systematic analysis of interactions of market with the suppliers via several market indices as well as forecasting important indices by artificial neural networks. Besides, the proposed method considers the practical limitations in the system and deals with incomplete information handling, closely. Next, a strategic bidding approach is proposed for optimal bidding by the suppliers. In these investigations, the paper focus is on the experimental situation of Iran electricity market as a pay-as-bid market and a sample generating company with several generating units from this market is considered as the benchmark. The results of applying this approach to this generating company are representative of good performance of the proposed method.

  13. Injecting rabies immunoglobulin (RIG) into wounds only: A significant saving of lives and costly RIG.

    Science.gov (United States)

    Bharti, Omesh Kumar; Madhusudana, Shampur Narayan; Wilde, Henry

    2017-02-22

    An increasing number of dog bite victims were being presented to public hospitals in Himachal Pradesh in 2014 amidst virtual non availability of any rabies immunoglobulin (RIG). Only a small quantity of equine rabies immunoglobulin (eRIG) was available from the government owned Central Research Institute (CRI) Kasauli. This available eRIG was used in 269 patients as an emergency response and only for local infiltration of severe bite wounds by suspected rabid dogs. This was followed by rabies vaccination, using the WHO approved intra-dermal Thai Red Cross Society vaccination schedule. A subgroup of 26 patients were later identified who had been severely bitten by laboratory confirmed rabid dogs. They were followed for more than one year and all were found to be alive.

  14. Endurance test on IR rig for RI production

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Heung June; Youn, Y. J.; Han, H. S.; Hong, S. B.; Cho, Y. G.; Ryu, J. S

    2000-12-01

    This report presents the pressure drop, vibration and endurance test results for IR rig for RI production which were desigened and fabricated by KAERI. From the pressure drop test results, it is noted that the flow rate through the IR rig corresponding to the pressure drop of 200 kPa is measured to be about 3.12 kg/sec. Vibration frequency for the IR rig ranges from 13 to 17 Hz. RMS(Root Mean Square) displacement for the IR rig is less than 30 {mu}m, and the maximum displacement is less than 110{mu}m. These experimental results show that the design criteria of IR rig meet the HANARO limit conditions. Endurance test results show that the appreciable fretting wear for the IR rig does not occur, however tiny trace of wear between contact points is observed.

  15. Strategic Bidding Behaviors in Nondecreasing Sponsored Search Auctions

    Directory of Open Access Journals (Sweden)

    Chen-Kun Tsung

    2013-01-01

    Full Text Available To realize the specific results in the sponsored search auctions, most advertisers submit particular bid prices. The bidding behaviors with specific purposes are called as the strategic bidding. However, some strategic bidding behaviors will result in negative effects, such as the elimination of the equilibrium and the payment increase for some advertisers. The bidding behaviors with negative results are termed as the vindictive bidding. We survey four strategic bidding behaviors which include a rational bidding and three vindictive bidding strategies. In this paper, we study the relationship between the effects resulted by the vindictive bidding and the valuations of the vindictive advertisers. In our experiments, the search engine provider (SEP is benefited by all vindictive bidding behaviors, and the increment of the SEP's revenue is proportional to the degree of the vindictiveness. Bidding vindictively without sacrificing the own utility improves the advertiser's utility with high probability. Moreover, we observe that the SEP's revenue is improved by the following situations. First, the vindictive advertiser with low valuation in the keywords with high market value results in more SEP's revenue than that in the keywords with low market value. The second case is to raise the bidding competition between advertisers.

  16. Innovative technology for a cost-effective land rig

    Energy Technology Data Exchange (ETDEWEB)

    Mehra, S.; Bryce, T.

    1996-05-01

    Sedco Forex has recently completed a new land drilling rig, currently deployed in Gabon, that integrates well construction activities with multiskilling to create cost savings across the board in drilling operations. Historically, operators have produced a comprehensive tender package specifying strictly the type and size of individual rig components and the number of personnel required to drill. In this case, the drilling contractor provides a fit-for-purpose rig, consistent with field location, well profile, operator`s priorities, and local constraints.

  17. Who Dominates the Semi-submersible Rig Market?

    Institute of Scientific and Technical Information of China (English)

    Yang Qingxia; Liu Chengming; LiangYuanhua

    2011-01-01

    Currently, the US and Europe are the centers for the design of semi-submersible rigs.The American company FRIEDE & GOLDMAN was founded in the 1950s. At present, over 100 mobile offshore drilling units and production platforms in the world are designed by this company, which mainly has two types of deepwater semi-submersible rig, F&GExD and MillenniumSA. F&GExD is the semi-submersible rig of the sixth generation and its operational depth can reach up to 3050m. MillenniumSA is semi-submersible rig of the fifth and half generation with an operational depth of 2400m.

  18. Eigenfunction expansions and scattering theory in rigged Hilbert spaces

    Energy Technology Data Exchange (ETDEWEB)

    Gomez-Cubillo, F [Dpt. de Analisis Matematico, Universidad de Valladolid. Facultad de Ciencias, 47011 Valladolid (Spain)], E-mail: fgcubill@am.uva.es

    2008-08-15

    The work reviews some mathematical aspects of spectral properties, eigenfunction expansions and scattering theory in rigged Hilbert spaces, laying emphasis on Lippmann-Schwinger equations and Schroedinger operators.

  19. Field Demonstraton of Existing Microhole Coiled Tubing Rig (MCTR) Technology

    Energy Technology Data Exchange (ETDEWEB)

    Kent Perry; Samih Batarseh; Sheriff Gowelly; Thomas Hayes

    2006-05-09

    The performance of an advanced Microhole Coiled Tubing Rig (MCTR) has been measured in the field during the drilling of 25 test wells in the Niobrara formation of Western Kansas and Eastern Colorado. The coiled tubing (CT) rig designed, built and operated by Advanced Drilling Technologies (ADT), was documented in its performance by GTI staff in the course of drilling wells ranging in depth from 500 to nearly 3,000 feet. Access to well sites in the Niobrara for documenting CT rig performance was provided by Rosewood Resources of Arlington, VA. The ADT CT rig was selected for field performance evaluation because it is one of the most advanced commercial CT rig designs that demonstrate a high degree of process integration and ease of set-up and operation. Employing an information collection protocol, data was collected from the ADT CT rig during 25 drilling events that encompassed a wide range of depths and drilling conditions in the Niobrara. Information collected included time-function data, selected parametric information indicating CT rig operational conditions, staffing levels, and field observations of the CT rig in each phase of operation, from rig up to rig down. The data obtained in this field evaluation indicates that the ADT CT rig exhibited excellent performance in the drilling and completion of more than 25 wells in the Niobrara under varied drilling depths and formation conditions. In the majority of the 25 project well drilling events, ROP values ranged between 300 and 620 feet per hour. For all but the lowest 2 wells, ROP values averaged approximately 400 feet per hour, representing an excellent drilling capability. Most wells of depths between 500 and 2,000 feet were drilled at a total functional rig time of less than 16 hours; for wells as deep at 2,500 to 3,000 feet, the total rig time for the CT unit is usually well under one day. About 40-55 percent of the functional rig time is divided evenly between drilling and casing/cementing. The balance of

  20. A BID on mitochondria with MTCH2

    Institute of Scientific and Technical Information of China (English)

    Sara Cogliati; Luca Scorrano

    2010-01-01

    @@ Apoptosis is a key process for tissue homeostasis and renewal. Its dysregulation is implicated in most human diseases, from cancer to neurodegeneration. Apoptosis is triggered by stimuli that damage the internal structures of the cell, or by specialized "death"receptors on its surface. In certain cell types, Bid, a "BH3-only" member of the Bcl-2 family of death regulators integrates these two pathways at the mitochondrial level. Despite years of intense research, the mechanisms by which Bid translocates to mitochondria remain unclear. A recent study by Gross and colleagues sheds new light on this process.

  1. 48 CFR 14.202-8 - Electronic bids.

    Science.gov (United States)

    2010-10-01

    ... subpart 4.5, contracting officers may authorize use of electronic commerce for submission of bids. If electronic bids are authorized, the solicitation shall specify the electronic commerce method(s) that bidders... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Electronic bids....

  2. 47 CFR 1.2104 - Competitive bidding mechanisms.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Competitive bidding mechanisms. 1.2104 Section 1.2104 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Competitive Bidding Proceedings General Procedures § 1.2104 Competitive bidding mechanisms. (a)...

  3. 48 CFR 731.771 - Bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ...) below, bid and proposal costs of the current accounting period of both successful and unsuccessful bids and proposals normally should be treated as indirect costs for allocation to all current activities, and no bid and proposal costs of past accounting periods will be allocable to the current...

  4. 48 CFR 814.404-2 - Rejection of individual bids.

    Science.gov (United States)

    2010-10-01

    ... reject the offer simply because it specifies a bid acceptance time that is shorter than that contained in... that the bid as submitted is in such a form that acceptance would create a valid and binding contract... determination that the bid as submitted is in such form that acceptance would not create a valid and...

  5. Synthetic Evaluation on Decision of Public Bidding for Construction Project

    Institute of Scientific and Technical Information of China (English)

    孙涛; 颜秋许

    2002-01-01

    Public bidding is the international current practice to contract construction project. But the decision on the bidding often is made according to the qualitative evaluation based on the subjective opinion of specialists. Therefore, the fuzzy mathematics principle was applied and a synthetic evaluation model was established to provide an effective method for the development of quantitative bidding decision in this paper.

  6. 36 CFR 223.88 - Bidding methods.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bidding methods. 223.88 Section 223.88 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND... determines that departures are necessary to protect the public interest. (f) The Chief, Forest Service,...

  7. Bidding Strategies in Brazilian Treasury Auctions

    Directory of Open Access Journals (Sweden)

    Anderson Caputo Silva

    2003-06-01

    Full Text Available Most empirical work in treasury auctions use aggregate auction results to examine bidding behavior. We investigate the strategies of bidders in Brazilian treasury auctions using both aggregate and bidder level data and find that more detailed information allows great improvements in the understanding of bidding behavior in treasury auctions. Classifying bidders according to characteristics regarding their institutional category and their nationality, we find evidence of distinct bidding behavior across types of bidders. Moreover, in line with previous evidence in auctions of Japanese government securities, we find that foreign bidders seem to obtain higher profits than those of national institutions. These results suggest that caution should be exercised in the interpretation of testes of bidding behavior that do not take differences in bidder’s characteristics into account and (or that assume that treasury securities are pure common-value goods. We find that Brazilian auctions are relatively illiquid as higher competition yields lower bidders’ discounts. Contrary to theoretical predictions of both common- and private-value auctions, we also find that bidders obtain lower profits in auctions with higher dispersion in bidders’ valuations.

  8. Five bid to host Middle East synchroton

    CERN Multimedia

    McCabe, H

    1999-01-01

    Germany is willing to donate a synchrotron to a research centre to be built somewhere in the Middle East. Bids to host the centre were submitted by Turkey, Cyprus, Iran, the Palestinian Authority and Egypt. Funding of at least 30 million US dollars still needs to be found (1 page).

  9. The Kieffer dough and gluten extensibility rig - An experimental evaluation

    NARCIS (Netherlands)

    Dunnewind, B.; Sliwinski, E.L.; Grolle, K.; Vliet, T. van

    2003-01-01

    Load-extension tests on flour dough are widely used by plant breeders, millers and bakers. The 'Kieffer dough and gluten extensibility rig' is a small-scale version of the Brabender extensograph, in which test pieces of about 0.4 g are extended. With the Kieffer rig, lower strain rates can be applie

  10. Advanced Hot Section Materials and Coatings Test Rig

    Energy Technology Data Exchange (ETDEWEB)

    Dan Davis

    2006-09-30

    Phase I of the Hyperbaric Advanced Hot Section Materials & Coating Test Rig Program has been successfully completed. Florida Turbine Technologies has designed and planned the implementation of a laboratory rig capable of simulating the hot gas path conditions of coal gas fired industrial gas turbine engines. Potential uses of this rig include investigations into environmental attack of turbine materials and coatings exposed to syngas, erosion, and thermal-mechanical fatigue. The principle activities during Phase 1 of this project included providing several conceptual designs for the test section, evaluating various syngas-fueled rig combustor concepts, comparing the various test section concepts and then selecting a configuration for detail design. Conceptual definition and requirements of auxiliary systems and facilities were also prepared. Implementation planning also progressed, with schedules prepared and future project milestones defined. The results of these tasks continue to show rig feasibility, both technically and economically.

  11. Endothelial RIG-I activation impairs endothelial function

    Energy Technology Data Exchange (ETDEWEB)

    Asdonk, Tobias, E-mail: tobias.asdonk@ukb.uni-bonn.de [Department of Medicine/Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn (Germany); Motz, Inga; Werner, Nikos [Department of Medicine/Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn (Germany); Coch, Christoph; Barchet, Winfried; Hartmann, Gunther [Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn (Germany); Nickenig, Georg; Zimmer, Sebastian [Department of Medicine/Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn (Germany)

    2012-03-30

    Highlights: Black-Right-Pointing-Pointer RIG-I activation impairs endothelial function in vivo. Black-Right-Pointing-Pointer RIG-I activation alters HCAEC biology in vitro. Black-Right-Pointing-Pointer EPC function is affected by RIG-I stimulation in vitro. -- Abstract: Background: Endothelial dysfunction is a crucial part of the chronic inflammatory atherosclerotic process and is mediated by innate and acquired immune mechanisms. Recent studies suggest that pattern recognition receptors (PRR) specialized in immunorecognition of nucleic acids may play an important role in endothelial biology in a proatherogenic manner. Here, we analyzed the impact of endothelial retinoic acid inducible gene I (RIG-I) activation upon vascular endothelial biology. Methods and results: Wild type mice were injected intravenously with 32.5 {mu}g of the RIG-ligand 3pRNA (RNA with triphosphate at the 5 Prime end) or polyA control every other day for 7 days. In 3pRNA-treated mice, endothelium-depended vasodilation was significantly impaired, vascular oxidative stress significantly increased and circulating endothelial microparticle (EMP) numbers significantly elevated compared to controls. To gain further insight in RIG-I dependent endothelial biology, cultured human coronary endothelial cells (HCAEC) and endothelial progenitor cells (EPC) were stimulated in vitro with 3pRNA. Both cells types express RIG-I and react with receptor upregulation upon stimulation. Reactive oxygen species (ROS) formation is enhanced in both cell types, whereas apoptosis and proliferation is not significantly affected in HCAEC. Importantly, HCAEC release significant amounts of proinflammatory cytokines in response to RIG-I stimulation. Conclusion: This study shows that activation of the cytoplasmatic nucleic acid receptor RIG-I leads to endothelial dysfunction. RIG-I induced endothelial damage could therefore be an important pathway in atherogenesis.

  12. Investigating Knowledge Transfer Mechanisms for Oil Rigs

    DEFF Research Database (Denmark)

    Vianello, Giovanna; Ahmed, Saeema

    2009-01-01

    It is widely recognized, both in industry and academia, that clear strategies in knowledge transfer positively influence the success of a firm. A firm should support the transfer of knowledge by standardizing communication channels within and across departments, based upon personalization......, codification or a combination of these two strategies. The characteristics of the business influence the choice of communication channels used for knowledge transfer. This paper presents a case study exploring the transfer of knowledge within and across projects, specifically the transfer of service knowledge...... in the case of complex machinery. The strategies used for knowledge transfer were analysed and compared with the expected transfer mechanisms, similarities and differences were investigated and are described. A family of four identical rigs for offshore drilling was the selected case. The transfer...

  13. Development of Magnetorheological Engine Mount Test Rig

    Directory of Open Access Journals (Sweden)

    Md Yunos Mohd Razali

    2017-01-01

    Full Text Available Ride comfort is an important factor in any road vehicle performance. Nonetheless, passenger ride comfort is sometimes affected by the vibrations resulting from the road irregularities. Vehicle ride comfort is also often compromised by engine vibration. Engine mount is one of the devices which act as vibration isolator from unwanted vibration from engine to the driver and passengers. This paper explains the development of the test rig used for laboratory testing of Magnetorheological (MR engine mount characterization. MR engine mount was developed to investigate the vibration isolation process. An engine mount test machine was designed to measure the displacement, relative velocity and damper force with respect to current supply to characterize the hysteresis behavior of the damper and as force tracking control of the MR engine mount.

  14. Tractor accelerated test on test rig

    Directory of Open Access Journals (Sweden)

    M. Mattetti

    2013-09-01

    Full Text Available The experimental tests performed to validate a tractor prototype before its production, need a substantial financial and time commitment. The tests could be reduced using accelerated tests able to reproduce on the structural part of the tractor, the same damage produced on the tractor during real life in a reduced time. These tests were usually performed reproducing a particular harsh condition a defined number of times, as for example using a bumpy road on track to carry out the test in any weather condition. Using these procedures the loads applied on the tractor structure are different with respect to those obtained during the real use, with the risk to apply loads hard to find in reality. Recently it has been demonstrated how, using the methodologies designed for cars, it is possible to also expedite the structural tests for tractors. In particular, automotive proving grounds were recently successfully used with tractors to perform accelerated structural tests able to reproduce the real use of the machine with an acceleration factor higher than that obtained with the traditional methods. However, the acceleration factor obtained with a tractor on proving grounds is in any case reduced due to the reduced speed of the tractors with respect to cars. In this context, the goal of the paper is to show the development of a methodology to perform an accelerated structural test on a medium power tractor using a 4 post test rig. In particular, several proving ground testing conditions have been performed to measure the loads on the tractor. The loads obtained were then edited to remove the not damaging portion of signals, and finally the loads obtained were reproduced in a 4 post test rig. The methodology proposed could be a valid alternative to the use of a proving ground to reproduce accelerated structural tests on tractors.

  15. Model for Bidding and Tendering with Bill of Quantities Based on Bid-Winning Estimate at Reasonable Low Price

    Institute of Scientific and Technical Information of China (English)

    Song Jirong; Zhong Sheng; Guo Yaohuang

    2006-01-01

    The possibility and rationality of introducing an bid-winning estimate based on a reasonable low price into construction bidding mode with bill of quantities were analyzed by setting up a model for bidding and tendering, and the functions of the estimate of reasonable low price in the bidding were revealed. On this basis, a new bidding mode of the project with bill of quantities was proposed. The application of the new mode will be advantageous to the promotion of the bill of quantities in China.

  16. A power recirculating test rig for ball screw endurance tests

    Directory of Open Access Journals (Sweden)

    Giberti Hermes

    2016-01-01

    Full Text Available A conceptual design of an innovative test rig for endurance tests of ball screws is presented in this paper. The test rig layout is based on the power recirculating principle and it also allows to overtake the main critical issues of the ball screw endurance tests. Among these there are the high power required to make the test, the lengthy duration of the same and the high loads between the screw and the frame that holds it. The article describes the test rig designed scheme, the kinematic expedients to be adopted in order to obtain the required performance and functionality and the sizing procedure to choose the actuation system.

  17. Testing for voter rigging in small polling stations

    CERN Document Server

    Jiménez, Raúl; Klimek, Peter

    2016-01-01

    Since the 1970s there has been a large number of countries that combine formal democratic institutions with authoritarian practices. Although in such countries the ruling elites may receive considerable voter support they often employ several manipulation tools to control election outcomes. A common practice of these regimes is the coercion and mobilization of a significant amount of voters to guarantee the electoral victory. This electoral irregularity is known as voter rigging, distinguishing it from vote rigging, which involves ballot stuffing or stealing. Here we develop a statistical test to quantify to which extent the results of a particular election display traces of voter rigging. Our key hypothesis is that small polling stations are more susceptible to voter rigging, because it is easier to identify opposing individuals, there are less eye witnesses, and supposedly less visits from election observers. We devise a general statistical method for testing whether voting behavior in small polling station...

  18. 46 CFR 162.050-17 - Separator test rig.

    Science.gov (United States)

    2010-10-01

    ... operate; and (4) Have either bypass piping to its suction side or a throttle valve or orifice on its discharge side. (c) The inlet piping of the test rig must be sized so that— (1) Influent water flows at...

  19. China-made Oil Rigs Well Sold on International Market

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    @@ By the end of July, ChinaPetroleum Technology Development Company (CPTDC), one of CNPC's subsidiaries, has cumulatively sold 26 oil drilling rigs worth more than US$200 million in the past three years.

  20. Marshall Space Flight Center High Speed Turbopump Bearing Test Rig

    Science.gov (United States)

    Gibson, Howard; Moore, Chip; Thom, Robert

    2000-01-01

    The Marshall Space Flight Center has a unique test rig that is used to test and develop rolling element bearings used in high-speed cryogenic turbopumps. The tester is unique in that it uses liquid hydrogen as the coolant for the bearings. This test rig can simulate speeds and loads experienced in the Space Shuttle Main Engine turbopumps. With internal modifications, the tester can be used for evaluating fluid film, hydrostatic, and foil bearing designs. At the present time, the test rig is configured to run two ball bearings or a ball and roller bearing, both with a hydrostatic bearing. The rig is being used to evaluate the lifetimes of hybrid bearings with silicon nitride rolling elements and steel races.

  1. Technical specification for IR rig manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Han Hyon Soo; Cho, W. K.; Kim, S. D.; Park, U. J.; Hong, S. B.; Yoo, K. M

    2000-10-01

    IR Rig is one of the equipments are required in HANARO core for a radioisotope target. The various conditions like high radiation, high heat, rapid flow and vibration may cause swelling, Brittleness and acceleration of corrosion in HANARO core. These specific problems can be prevented and the safety of such equipment are prerequisite as well as durableness and surveillance. Therefore, the selection of material has to be made on the basis of small cross-section area, low energy emission by the gamma ray due to the absorption of neutron and short half life. The body is consist of aluminum and Inconel-750 was used for the internal spring(coil) which is known to be durable. The whole production process including the purchase of accessory, mechanical processing, welding and assembly was carried out according to the standard procedure to meet the requirement. A design, manufacture, utilization of reactor core and the other relevant uses were fit to class ''T'' to certify the whole process as general. And design, fabrication, analytical test, materials and accessory were carried out based on the ASME, ASTM, ANSI, AWS, JIS and KS standard.

  2. Auctioning Process Innovations when Losers' Bids Determine Royalty Rates

    OpenAIRE

    Fan, Cuihong; Jun, Byoung Heon; Elmar G. Wolfstetter

    2009-01-01

    We consider a licensing mechanism for process innovations that combines a license auction with royalty contracts to those who lose the auction. Firms’ bids are dual signals of their cost reductions: the winning bid signals the own cost reduction to rival oligopolists, whereas the losing bid influences the beliefs of the innovator who uses that information to set the royalty rate. We derive conditions for existence of a separating equilibrium, explain why a sufficiently high reserve price is e...

  3. Review of consolidated Edison`s integrated resource bidding program

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, C.A.; Busch, J.F.; Kahn, E.P.; Baldick, R.; Milne, A.

    1993-07-01

    Competitive bidding has emerged as the dominant method for procuring new resources by US utilities. In New York, the Public Service Commission (NYPSC) ordered the state`s seven investor-owned utilities to develop bidding programs to acquire supply and DSM resource options. Utilities were allowed significant discretion in program design in order to encourage experimentation. Competitive bidding programs pose formidable policy, design, and management challenges for utilities and their regulators. Yet, there have been few detailed case studies of bidding programs, particularly of those utilities that take on the additional challenge of having supply and DSM resources compete head-to-head for a designated block of capacity. To address that need, the New York State Energy Research and Development Authority (NYSERDA), the New York Department of Public Service, and the Department of Energy`s Integrated Resource Planning program asked Lawrence Berkeley Laboratory (LBL) to review the bidding programs of two utilities that tested the integrated ``all-sources`` approach. This study focuses primarily on Consolidated Edison Company of New York`s (Con Edison) bidding program; an earlier report discusses our review of Niagara Mohawk`s program (Goldman et al 1992). We reviewed relevant Commission decisions, utility filings and signed contracts, interviewed utility and regulatory staff, surveyed DSM bidders and a selected sample of DSM non-bidders, and analyzed the bid evaluation system used in ranking bids based on detailed scoring information on individual bids provided by Con Edison.

  4. Gastrostomy insertion: comparing the options - PEG, RIG or PIG?

    Energy Technology Data Exchange (ETDEWEB)

    Laasch, H.-U. E-mail: hul@smtr.nhs.uk; Wilbraham, L.; Bullen, K.; Marriott, A.; Lawrance, J.A.L.; Johnson, R.J.; Lee, S.H.; England, R.E.; Gamble, G.E.; Martin, D.F

    2003-05-01

    AIM: To compare percutaneous endoscopic gastrostomy (PEG) with radiologically inserted gastrostomy (RIG) and assess a hybrid gastrostomy technique (per-oral image-guided gastrostomy, PIG). MATERIALS AND METHODS: Fifty PEGs and 50 RIGs performed in three centres were prospectively compared and the endoscopic findings of 200 PEGs reviewed. A fluoroscopy-guided technique was modified to place 20 F over-the-wire PEG-tubes in 60 consecutive patients. RESULTS: Technical success was 98%, 100% and 100% for PEG, RIG and PIG, respectively. Antibiotic prophylaxis significantly reduced stoma infection for orally placed tubes (p=0.02). Ten out of 50 (20%) small-bore RIG tubes blocked. Replacement tubes were required in six out of 50 PEGs (12%), 10 out of 50 RIGs (20%), but no PIGs (p<0.001). No procedure-related complications occurred. The function of radiologically placed tubes was significantly improved with the larger PIG (p<0.001), with similar wound infection rates. PIG was successful in 24 patients where endoscopic insertion could not be performed. Significant endoscopic abnormalities were found in 42 out of 200 PEG patients (21%), all related to peptic disease. Insignificant pathology was found in 8.5%. CONCLUSION: PIG combines advantages of both traditional methods with a higher success and lower re-intervention rate. Endoscopy is unlikely to detect clinically relevant pathology other than peptic disease. PIG is a very effective gastrostomy method; it has better long-term results than RIG and is successful where conventional PEG has failed.

  5. 42 CFR 414.412 - Submission of bids under a competitive bidding program.

    Science.gov (United States)

    2010-10-01

    ... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Competitive Bidding for Certain Durable Medical Equipment, Prosthetics, Orthotics, and Supplies.... Except as provided under § 414.404(b), in order for a supplier to receive payment for items furnished...

  6. The bidding paradox: why rational politicians still want to bid for mega sports events

    NARCIS (Netherlands)

    de Nooij, M.; van den Berg, M.R.

    2013-01-01

    This paper discusses reasons why politicians still favor hosting mega events despite the discouraging evidence regarding their financial benefits: (1) early political enthusiasm, (2) tying side-projects to the bid to raise political support, (3) biased reading of history, (4) the winners curse, (5)

  7. ATTac-2000: An Adaptive Autonomous Bidding Agent

    CERN Document Server

    Kearns, M; Singh, S; Stone, P; 10.1613/jair.865

    2011-01-01

    The First Trading Agent Competition (TAC) was held from June 22nd to July 8th, 2000. TAC was designed to create a benchmark problem in the complex domain of e-marketplaces and to motivate researchers to apply unique approaches to a common task. This article describes ATTac-2000, the first-place finisher in TAC. ATTac-2000 uses a principled bidding strategy that includes several elements of adaptivity. In addition to the success at the competition, isolated empirical results are presented indicating the robustness and effectiveness of ATTac-2000's adaptive strategy.

  8. Bidding for Representative Allocations for Display Advertising

    CERN Document Server

    Ghosh, Arpita; Papineni, Kishore; Vassilvitskii, Sergei

    2009-01-01

    Display advertising has traditionally been sold via guaranteed contracts -- a guaranteed contract is a deal between a publisher and an advertiser to allocate a certain number of impressions over a certain period, for a pre-specified price per impression. However, as spot markets for display ads, such as the RightMedia Exchange, have grown in prominence, the selection of advertisements to show on a given page is increasingly being chosen based on price, using an auction. As the number of participants in the exchange grows, the price of an impressions becomes a signal of its value. This correlation between price and value means that a seller implementing the contract through bidding should offer the contract buyer a range of prices, and not just the cheapest impressions necessary to fulfill its demand. Implementing a contract using a range of prices, is akin to creating a mutual fund of advertising impressions, and requires {\\em randomized bidding}. We characterize what allocations can be implemented with rando...

  9. 47 CFR 90.903 - Competitive bidding mechanisms.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Competitive bidding mechanisms. 90.903 Section 90.903 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO... Radio Service § 90.903 Competitive bidding mechanisms. (a) Sequencing. The Wireless...

  10. Bid Optimization in Broad-Match Ad auctions

    CERN Document Server

    Even-dar, Eyal; Mirrokni, Vahab; Muthukrishnan, S; Nadav, Uri

    2009-01-01

    Ad auctions in sponsored search support ``broad match'' that allows an advertiser to target a large number of queries while bidding only on a limited number. While giving more expressiveness to advertisers, this feature makes it challenging to optimize bids to maximize their returns: choosing to bid on a query as a broad match because it provides high profit results in one bidding for related queries which may yield low or even negative profits. We abstract and study the complexity of the {\\em bid optimization problem} which is to determine an advertiser's bids on a subset of keywords (possibly using broad match) so that her profit is maximized. In the query language model when the advertiser is allowed to bid on all queries as broad match, we present an linear programming (LP)-based polynomial-time algorithm that gets the optimal profit. In the model in which an advertiser can only bid on keywords, ie., a subset of keywords as an exact or broad match, we show that this problem is not approximable within any ...

  11. 48 CFR 2052.214-72 - Bid evaluation.

    Science.gov (United States)

    2010-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.214-72 Bid evaluation. As... be made to that responsive, responsible bidder within the meaning of FAR Subpart 9.1 whose total bid... the bidder is responsible within the meaning of FAR 9.1, and whether the bidder...

  12. Bidding in sequential electricity markets: The Nordic case

    DEFF Research Database (Denmark)

    Boomsma, Trine Krogh; Juul, Nina; Fleten, Stein-Erik

    2014-01-01

    For electricity market participants trading in sequential markets with differences in price levels and risk exposure, coordinated bidding is highly relevant. We consider a Nordic power producer who engages in the day-ahead spot market and the near real-time balancing market. In both markets......, clearing prices and dispatched volumes are unknown at the time of bidding. However, in the balancing market, the agent faces an additional risk of not being dispatched. Taking into account the sequential clearing of these markets and the gradual realization of market prices, we formulate the bidding...... problem as a multi-stage stochastic program. We investigate whether higher risk exposure can explain the hesitation, often observed in practice, to bid into the balancing market, even in cases of higher expected price levels. Furthermore, we quantify the gain from coordinated bidding, and by deriving...

  13. Advanced jack up rig breaking U.S. construction drought

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, P. [Rowan Companies Inc., Houston, TX (United States)

    1997-03-10

    A new heavy duty jack up, due in mid-1998, will be able to simultaneously drill and produce wells in harsher environments and deeper water than current jack ups in the worldwide fleet. Rowan Cos. Inc.`s Gorilla V is the only mobile offshore drilling unit (MODU) currently under construction in the US. Two more enhanced Gorilla design rigs are planned before the year 2000. The enhanced Gorilla class jack up represents the most technologically advanced jack up unit constructed to date. The rigs are structurally designed to meet year-round weather challenges in the harshest geographical environments. Rising demand for drilling rigs, coupled with a dwindling fleet, is generating supply shortages around the world, particularly at the high-specification end of the market. Even increasing the historical retirement age from 20 to 25 years, rig attrition continues at a level of about 18 rigs per year. Apart from the jack up market per se, however, Rowan`s strategy in designing and building enhanced Gorillas is to improve existing jack up drilling technology and offer the versatility to operate as a drilling unit, a mobile production unit, or both simultaneously in either open water locations or alongside existing platforms. The paper discusses the market for these heavy jack-ups, the use of one on the Cohasset project in Nova Scotia, the Gorilla V and enhanced Gorillas, geographical range of use, and MOPU economics.

  14. RIG-I and dsRNA-induced IFNbeta activation.

    Directory of Open Access Journals (Sweden)

    Stéphane Hausmann

    Full Text Available Except for viruses that initiate RNA synthesis with a protein primer (e.g., picornaviruses, most RNA viruses initiate RNA synthesis with an NTP, and at least some of their viral (pppRNAs remain unblocked during the infection. Consistent with this, most viruses require RIG-I to mount an innate immune response, whereas picornaviruses require mda-5. We have examined a SeV infection whose ability to induce interferon depends on the generation of capped dsRNA (without free 5' tri-phosphate ends, and found that this infection as well requires RIG-I and not mda-5. We also provide evidence that RIG-I interacts with poly-I/C in vivo, and that heteropolymeric dsRNA and poly-I/C interact directly with RIG-I in vitro, but in different ways; i.e., poly-I/C has the unique ability to stimulate the helicase ATPase of RIG-I variants which lack the C-terminal regulatory domain.

  15. Design and Characterization of a Centrifugal Compressor Surge Test Rig

    Directory of Open Access Journals (Sweden)

    Kin Tien Lim

    2011-01-01

    Full Text Available A detailed description of a new centrifugal compressor surge test rig is presented. The objective of the design and development of the rig is to study the surge phenomenon in centrifugal compression systems and to investigate a novel method of surge control by active magnetic bearing servo actuation of the impeller axial tip clearance. In this paper, we focus on the design, initial setup, and testing of the rig. The latter two include the commissioning of the rig and the experimental characterization of the compressor performance. The behavior of the compressor during surge is analyzed by driving the experimental setup into surge. Two fundamental frequencies, 21 Hz and 7 Hz, connected to the surge oscillation in the test rig are identified, and the observed instability is categorized according to the intensity of pressure fluctuations. Based on the test results, the excited pressure waves are clearly the result of surge and not stall. Also, they exhibit the characteristics of mild and classic surge instead of deep surge. Finally, the change in the compressor performance due to variation in the impeller tip clearance is experimentally examined, and the results support the potential of the tip clearance modulation for the control of compressor surge. This is the first such demonstration of the feasibility of surge control of a compressor using active magnetic bearings.

  16. Heat-and-pull rig for fiber taper fabrication

    Science.gov (United States)

    Ward, Jonathan M.; O'Shea, Danny G.; Shortt, Brian J.; Morrissey, Michael J.; Deasy, Kieran; Nic Chormaic, Síle G.

    2006-08-01

    We describe a reproducible method of fabricating adiabatic tapers with 3-4μm diameter. The method is based on a heat-and-pull rig, whereby a CO2 laser is continuously scanned across a length of fiber that is being pulled synchronously. Our system relies on a CO2 mirror mounted on a geared stepper motor in order to scan the laser beam across the taper region. We show that this system offers a reliable alternative to more traditional rigs incorporating galvanometer scanners. We have routinely obtained transmission losses between 0.1 and 0.3dB indicating the satisfactory production of adiabatic tapers. The operation of the rig is described in detail and an analysis on the produced tapers is provided. The flexibility of the rig is demonstrated by fabricating prolate dielectric microresonators using a microtapering technique. Such a rig is of interest to a range of fields that require tapered fiber fabrication such as microcavity-taper coupling, atom guiding along a tapered fiber, optical fiber sensing, and the fabrication of fused biconical tapered couplers.

  17. Determination of the Prosumer's Optimal Bids

    Science.gov (United States)

    Ferruzzi, Gabriella; Rossi, Federico; Russo, Angela

    2015-12-01

    This paper considers a microgrid connected with a medium-voltage (MV) distribution network. It is assumed that the microgrid, which is managed by a prosumer, operates in a competitive environment and participates in the day-ahead market. Then, as the first step of the short-term management problem, the prosumer must determine the bids to be submitted to the market. The offer strategy is based on the application of an optimization model, which is solved for different hourly price profiles of energy exchanged with the main grid. The proposed procedure is applied to a microgrid and four different its configurations were analyzed. The configurations consider the presence of thermoelectric units that only produce electricity, a boiler or/and cogeneration power plants for the thermal loads, and an electric storage system. The numerical results confirmed the numerous theoretical considerations that have been made.

  18. COSL Signs Rig Equipment Contract with US Company

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ China Oilfield Services Limited (COSL), the leading integrated oilfield services provider in China for the offshore oil market, has recently signed an equipment purchase contract with the US-based National Oilwell L.P. Under the US$30-million contract, National Oilwell provide four sets of equipment for COSL's new 400-feet jack-up drilling rig under construction, consisting of a drilling system, a mud mixing and solid controlling system,a BOP handling system and a rig jacking system.National Oilwell will provide the drilling system on EPC basis, including its design, construction,equipment supply and commissioning.

  19. A Grey Decision Model Used in Bidding for Equipment Purchase

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Bidding has long been used as a method for allocating and procuring goods andservices.An acurrate and comprehensive evaluation of bidders is the key to make the bid-ding a successful one for tenderee. Howoever, evaluation of bidders is a tough work and theresult of evaluation is always affected by the evaluator's understanding of the standardsset for evaluation, and the evaluator's expertise, experience and preferrence. We make aneffort to find a method for selecting bidders as accurately as possible. A grey decisionmodel is presented, and an example is illustrated to make the practioners kenow how to usethe model.

  20. ADP Bid Protests: Better Disclosure and Accountability of Settlements Needed

    Science.gov (United States)

    1990-03-01

    but Few A With Mosey S -7 The.Census Bureaus expeice and concern about ossCA’s bid 1rotest procedures prompted.a DN Aft•ment of Commerce official in...GAO/GGD-S-13 ADP Bid Protest Settlements * 4 r 0 @ Appendix I ADP Bid Protests Fil With the GSBCA and£ G O From April to September 30, 18N General...J. Socolar Special Assistant to the Comptroller General General Accounting Office 蚉 G Street, N.V. Vashington, D.C. 20548 Subject: Analysis of

  1. 41 CFR 102-38.210 - What happens when bids have been rejected?

    Science.gov (United States)

    2010-07-01

    ... have been rejected? 102-38.210 Section 102-38.210 Public Contracts and Property Management Federal... OF PERSONAL PROPERTY Bids Acceptance of Bids § 102-38.210 What happens when bids have been rejected? You may re-offer items for which all bids have been rejected at the same sale, if possible, or...

  2. The laboratory test rig with miniature jet engine to research aviation fuels combustion process

    OpenAIRE

    Gawron Bartosz; Białecki Tomasz

    2015-01-01

    This article presents laboratory test rig with a miniature turbojet engine (MiniJETRig – Miniature Jet Engine Test Rig), that was built in the Air Force Institute of Technology. The test rig has been developed for research and development works aimed at modelling and investigating processes and phenomena occurring in full scale jet engines. In the article construction of a test rig is described, with a brief discussion on the functionality of each of its main components. Additionally examples...

  3. Heat-and-pull rig for fiber taper fabrication

    NARCIS (Netherlands)

    Ward, Jonathan M.; O'Shea, Danny G.; Shortt, Brian J.; Morrissey, Michael J.; Deasy, Kieran; Chormaic, Sile G. Nic

    2006-01-01

    We describe a reproducible method of fabricating adiabatic tapers with 3-4 mu m diameter. The method is based on a heat-and-pull rig, whereby a CO(2) laser is continuously scanned across a length of fiber that is being pulled synchronously. Our system relies on a CO(2) mirror mounted on a geared ste

  4. On Improving International Competitiveness of China-Made Drilling Rigs

    Institute of Scientific and Technical Information of China (English)

    Gong Huijuan

    2009-01-01

    @@ Current state of technology for China made drilling rigs With accelerated oil & gas exploration and development,and the implementation of "going out"strategy in recent years,the manufacturing of drilling equipment has entered a phase of rapid development in China.

  5. Relationships Between Two Approaches: Rigged Configurations and 10-Eliminations

    Science.gov (United States)

    Kirillov, Anatol N.; Sakamoto, Reiho

    2009-07-01

    There are two distinct approaches to the study of initial value problem of the periodic box-ball systems. One way is the rigged configuration approach due to Kuniba-Takagi-Takenouchi and another way is the 10-elimination approach due to Mada-Idzumi-Tokihiro. In this paper, we describe precisely interrelations between these two approaches.

  6. DMPD: MDA5/RIG-I and virus recognition. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18272355 MDA5/RIG-I and virus recognition. Takeuchi O, Akira S. Curr Opin Immunol. ...2008 Feb;20(1):17-22. Epub 2008 Feb 12. (.png) (.svg) (.html) (.csml) Show MDA5/RIG-I and virus recognition.... PubmedID 18272355 Title MDA5/RIG-I and virus recognition. Authors Takeuchi O, Akira S. Publication Curr Opi

  7. 48 CFR 14.301 - Responsiveness of bids.

    Science.gov (United States)

    2010-10-01

    ... conditions that do not vary from the terms and conditions of the invitation. (e) Bids submitted by electronic commerce shall be considered only if the electronic commerce method was specifically stipulated...

  8. Engineer’s estimate reliability and statistical characteristics of bids

    Directory of Open Access Journals (Sweden)

    Fariborz M. Tehrani

    2016-12-01

    Full Text Available The objective of this report is to provide a methodology for examining bids and evaluating the performance of engineer’s estimates in capturing the true cost of projects. This study reviews the cost development for transportation projects in addition to two sources of uncertainties in a cost estimate, including modeling errors and inherent variability. Sample projects are highway maintenance projects with a similar scope of the work, size, and schedule. Statistical analysis of engineering estimates and bids examines the adaptability of statistical models for sample projects. Further, the variation of engineering cost estimates from inception to implementation has been presented and discussed for selected projects. Moreover, the applicability of extreme values theory is assessed for available data. The results indicate that the performance of engineer’s estimate is best evaluated based on trimmed average of bids, excluding discordant bids.

  9. Bid-Ask Spreads with Indirect Competition among Specialists

    OpenAIRE

    Gehrig, Thomas; Jackson, Matthew O.

    1997-01-01

    We examine the bid-ask quotes offered by specialists (or dealers) who face indirect competition from other specialists who trade in related assets. In the context of a simple model where investors have mean variance preferences, we characterize the equilibrium bids and asks quoted by K specialists in N assets, where some specialists may control more than one asset. We compare the equilibrium spreads as the number (and factor structure) of the assets each specialist controls is varied. It is s...

  10. Optimal Bidding Strategy for Renewable Microgrid with Active Network Management

    Directory of Open Access Journals (Sweden)

    Seung Wan Kim

    2016-01-01

    Full Text Available Active Network Management (ANM enables a microgrid to optimally dispatch the active/reactive power of its Renewable Distributed Generation (RDG and Battery Energy Storage System (BESS units in real time. Thus, a microgrid with high penetration of RDGs can handle their uncertainties and variabilities to achieve the stable operation using ANM. However, the actual power flow in the line connecting the main grid and microgrid may deviate significantly from the day-ahead bids if the bids are determined without consideration of the real-time adjustment through ANM, which will lead to a substantial imbalance cost. Therefore, this study proposes a formulation for obtaining an optimal bidding which reflects the change of power flow in the connecting line by real-time adjustment using ANM. The proposed formulation maximizes the expected profit of the microgrid considering various network and physical constraints. The effectiveness of the proposed bidding strategy is verified through the simulations with a 33-bus test microgrid. The simulation results show that the proposed bidding strategy improves the expected operating profit by reducing the imbalance cost to a greater degree compared to the basic bidding strategy without consideration of ANM.

  11. The laboratory test rig with miniature jet engine to research aviation fuels combustion process

    Directory of Open Access Journals (Sweden)

    Gawron Bartosz

    2015-12-01

    Full Text Available This article presents laboratory test rig with a miniature turbojet engine (MiniJETRig – Miniature Jet Engine Test Rig, that was built in the Air Force Institute of Technology. The test rig has been developed for research and development works aimed at modelling and investigating processes and phenomena occurring in full scale jet engines. In the article construction of a test rig is described, with a brief discussion on the functionality of each of its main components. Additionally examples of measurement results obtained during the realization of the initial tests have been included, presenting the capabilities of the test rig.

  12. Development of nanolubricant automotive air conditioning (AAC test rig

    Directory of Open Access Journals (Sweden)

    Redhwan A.A.M.

    2017-01-01

    Full Text Available Nanolubricant been introduced in compressor might improve the performance of automotive air conditioning system. Prior testing of the nanolubricant enhancement performance, an automotive air conditioning (AAC system test rig base on compact car has to be developed; therefore this paper presented the development process of AAC test rig. There are 15 thermocouples, 2 pressure gauges and power analyzer were assembled on the system in order to analyse its performance. The experiment was conducted with four different charged of refrigerant. The charging was based on initial weight charged. At each quantity of refrigerant charge, performance of the AAC system was evaluated by determining three important parameters which is cooling capacity, compressor work and coefficient of performance (COP. The maximum average COP is achieved at 900 RPM is 7.07. The average and maximum COP enhancement of 7.07 % and 13.34 % were achieved by applying SiO2 nanolubricant inside the compressor.

  13. RIG-A New Management Information System for Railway Transportation

    Institute of Scientific and Technical Information of China (English)

    Jian-Bo Wang; Da-Ke He; Yan Xu

    2009-01-01

    A grid technology together with data warehouse and mediator is used to develop the railway transport management information system (TMIS), which is aiming at managing and publishing all kinds of enterprise resources among dynamic collections of such information systems with heterogeneous architectures and distributed in geography within Chinese Ministry of Railway. As one logical information integration framework and a uniform interface for accessing resources, a prototype named railway information grid (RIG) is proposed. Its main modules and the key technologies, together with its feasibility, are discussed in detail. RIG can not only provide the integral information service and the interoperability of information at the application level, but also bring us such benefits as: easy use, high efficiency, and reasonable total cost of ownership.

  14. RESEARCH RIG FOR EXAMINATION OF PRESSURE IN HYRDODYNAMIC OIL FILM

    Directory of Open Access Journals (Sweden)

    Wojciech HORAK

    2014-06-01

    Full Text Available The paper presents a concept of a didactic research rig for investigation and visualization of pressure distribution in an oil film of a journal fluid friction slide bearing. The rig being presented may be used during classes on subjects associated machine design. The paper presents an idea of a specific design, using an asynchronic motor with a long shaft, on which the slide bearing assembly is fixed. The design is elastic and allows many modifications of the construction. The possible modifications are presented in the summary part of the paper. The paper also presents ideas for development of the design, either to enable measurements of additional physical values, or presentation of specific cases of slide bearings operation.

  15. Bidding strategies that minimize risk with options and futures contracts

    Energy Technology Data Exchange (ETDEWEB)

    Richter, C.W. Jr.; Sheble, G.B. [Iowa State Univ., Ames, IA (United States). Electrical and Computer Engineering

    1998-12-31

    This research builds on earlier research in developing bidding strategies through the inclusion of options and future contracts. In the competitive environment, electric traders` profits depends on the implementation of a successful bidding strategy. Bidding strategies are studied in an environment in which distribution companies (DISTCOs) and generation companies (GENCOs), buy and sell power via double auctions in regional commodity exchanges. The market framework being used was proposed by Kumar and Sheble and allows participants to trade in the spot, future, planning and swap markets, and also gives rise to the use of option contracts. Bid-strategy research previously published by the authors focused on increasing electric generators` profit as they participated in a spot/cash market. Here the authors incorporate techniques such as game theory and decision analysis to minimize the risk to the electric utility or energy trader. The goal is to ensure reliable power system operation while also ensuring that contracts are fulfilled and traders adopting the strategies remain profitable. The developed strategies are tested in the electric market trading simulator which can be used off-line to predict whether bid strategies will be profitable and successful.

  16. Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity.

    Science.gov (United States)

    Nie, Li; Zhang, Ying-sheng; Dong, Wei-ren; Xiang, Li-xin; Shao, Jian-zhong

    2015-01-01

    The retinoic acid-inducible gene I (RIG-I) is a critical sensor for host recognition of RNA virus infection and initiation of antiviral signaling pathways in mammals. However, data on the occurrence and functions of this molecule in lower vertebrates are limited. In this study, we characterized an RIG-I homolog (DrRIG-I) from zebrafish. Structurally, this DrRIG-I shares a number of conserved functional domains/motifs with its mammalian counterparts, namely, caspase activation and recruitment domain, DExD/H box, a helicase domain, and a C-terminal domain. Functionally, stimulation with DrRIG-I CARD in zebrafish embryos significantly activated the NF-κB and IFN signaling pathways, leading to the expression of TNF-α, IL-8 and IFN-induced Mx, ISG15, and viperin. However, knockdown of TRIM25 (a pivotal activator for RIG-I receptors) significantly suppressed the induced activation of IFN signaling. Results suggested the functional conservation of RIG-I receptors in the NF-κB and IFN signaling pathways between teleosts and mammals, providing a perspective into the evolutionary history of RIG-I-mediated antiviral innate immunity.

  17. Trend arbitrage, bid-ask spread and market dynamics

    CERN Document Server

    Zaitsev, N

    2006-01-01

    Microstructure of market dynamics is studied through analysis of tick price data. Linear trend is introduced as a tool for such analysis. Trend arbitrage inequality is developed and tested. The inequality sets limiting relationship between trend, bid-ask spread, market reaction and average update frequency of price information. Average time of market reaction is measured from market data. This parameter is interpreted as a constant value of the stock exchange and is attributed to the latency of exchange reaction to actions of traders. This latency and cost of trade are shown to be the main limit of bid-ask spread. Data analysis also suggests some relationships between trend, bid-ask spread and average frequency of price update process.

  18. Co-operative bidding of SMEs in health care sector.

    Science.gov (United States)

    Mezgár, István; Kovács, György; Bonfatti, Fabio

    2002-01-01

    Tendering become an important process for customers in the health care sector to select products and services from the market for the lowest price, with the highest quality and with the shortest delivery time. The number of SMEs (Small and Medium-sized Enterprises) delivering products or services for the health care sector is increasing, but they have usually limited capital and expertise to participate in tenders. The paper introduces a possible solution for this problem, when SMEs form special groups, so called Smart Bidding Organisations (SBO), to prepare a bid for the tender jointly. The SBO appears for the customer (tender issuer) as a single enterprise and the bidding procedure will be faster and less expensive in this way.

  19. Private Companies Hopeful to Bid on Oil Blocks

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Based on the recent reports from China's news media,China is considering opening oil exploration blocks in its smaller basins to private domestic private companies in what could be the first step toward introducing competition in the country's highly regulated upstream energy market. The Ministry of Land and Resources plans to develop a bidding system for exploration rights in small and mid-sized basins over the next five to 10 years.Trial bidding is expected to start in three to five years, the report said, citing Che Changbo, deputy chief of the Oil and Gas Resources Strategic Research Center under the land ministry.

  20. Models for electricity market efficiency and bidding strategy analysis

    Science.gov (United States)

    Niu, Hui

    This dissertation studies models for the analysis of market efficiency and bidding behaviors of market participants in electricity markets. Simulation models are developed to estimate how transmission and operational constraints affect the competitive benchmark and market prices based on submitted bids. This research contributes to the literature in three aspects. First, transmission and operational constraints, which have been neglected in most empirical literature, are considered in the competitive benchmark estimation model. Second, the effects of operational and transmission constraints on market prices are estimated through two models based on the submitted bids of market participants. Third, these models are applied to analyze the efficiency of the Electric Reliability Council Of Texas (ERCOT) real-time energy market by simulating its operations for the time period from January 2002 to April 2003. The characteristics and available information for the ERCOT market are considered. In electricity markets, electric firms compete through both spot market bidding and bilateral contract trading. A linear asymmetric supply function equilibrium (SFE) model with transmission constraints is proposed in this dissertation to analyze the bidding strategies with forward contracts. The research contributes to the literature in several aspects. First, we combine forward contracts, transmission constraints, and multi-period strategy (an obligation for firms to bid consistently over an extended time horizon such as a day or an hour) into the linear asymmetric supply function equilibrium framework. As an ex-ante model, it can provide qualitative insights into firms' behaviors. Second, the bidding strategies related to Transmission Congestion Rights (TCRs) are discussed by interpreting TCRs as linear combination of forwards. Third, the model is a general one in the sense that there is no limitation on the number of firms and scale of the transmission network, which can have

  1. Long Term Expected Revenue of Wind Farms Considering the Bidding Admission Uncertainty

    DEFF Research Database (Denmark)

    Bashi, Mazaher Haji; Yousefi, G.R.; Bak, Claus Leth;

    2016-01-01

    in the long term expected revenue of wind farms. We show that this consideration could perfectly explain the observed bid shading behavior of wind farm owners. We use a novel market price model with a stochastic model of a wind farm to derive indices describing the uncertainty of bidding admission......As a long term bidding behavior, bid shading is exhibited by wind farms participating in real Uniform Price (UP) markets. This signifies that the wind farm owners bid far below their true long run marginal cost. In this paper, a method is proposed to consider the uncertainty of bidding admission....... The optimal behavior of the wind farm is then obtained by establishing a multi objective optimization problem and subsequently solved using genetic algorithm. The method is applied to the analysis of long term bidding behavior of a wind farm participating in a Pay-as-Bid (PAB) auction such as Iran Electricity...

  2. ENERGY-SAVING TYPE OF HYDRAULIC WORKOVER RIG AND SIMULATION FOR LOWERING PIPESTRING

    Institute of Scientific and Technical Information of China (English)

    Zhang Lujun; Gu Xinyi; Chen Su

    2005-01-01

    Research has been done on an energy-saving type of hydraulic workover rig. This rig can recover and reuse the potential energy which is released by the pipestring when lowered, and the equipped power of this rig is only one third of an ordinary rig. The structure and theory of this rig are introduced. The mathematical model of lowering the pipestring is established and a simulation analysis is conducted. Through simulation some conclusions are obtained: The lighter the pipestring is, the less velocity of lowering the pipestring is; The smaller the throttle valve path area is, the less velocity of lowering the pipestring is; Different air vessel volumes have no evident effect on the pipestring lowering velocity. The actual measure results prove that the simulation results are right. Finally, the energy-saving effect of this rig is proved by the field test results.

  3. The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.

    Science.gov (United States)

    O'Neill, Luke A J; Bowie, Andrew G

    2011-10-14

    The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et al. (2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response.

  4. 48 CFR 31.205-18 - Independent research and development and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... Contracts With Commercial Organizations 31.205-18 Independent research and development and bid and proposal..., defined in this subsection. Basic research, (See 2.101). Bid and proposal (B&P) costs means the costs... 9904.420, Accounting for independent research and development costs and bid and proposal costs,...

  5. Script Fading to Promote Unscripted Bids for Joint Attention in Children with Autism

    Science.gov (United States)

    Pollard, Joy S.; Betz, Alison M.; Higbee, Thomas S.

    2012-01-01

    We used a script-fading procedure to teach 3 children with autism to initiate bids for joint attention. We examined the effects of (a) scripts, (b) varied adult scripted responses, and (c) multiple-exemplar script training on promoting unscripted language during bids for joint attention. All 3 participants learned to initiate bids for joint…

  6. 42 CFR 422.256 - Review, negotiation, and approval of bids.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including...

  7. 48 CFR 52.214-25 - Step Two of Two-Step Sealed Bidding.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Step Two of Two-Step... Clauses 52.214-25 Step Two of Two-Step Sealed Bidding. As prescribed in 14.201-6(t), insert the following provision: Step Two of Two-Step Sealed Bidding (APR 1985) (a) This invitation for bids is issued to...

  8. Design and Development of High-Velocity Slurry Erosion Test Rig Using CFD

    Science.gov (United States)

    Grewal, H. S.; Agrawal, Anupam; Singh, H.

    2013-01-01

    Slurry erosion (SE) is commonly observed in almost all kinds of components and machineries involved in fluid (liquid) transfer and delivery. During design and development phase of these components, test rigs are usually required to evaluate their performance; however, only few detailed designs of test rigs are available for SE investigations. Among the existing designs of SE test rigs, most of them belong to rotary type. In the present study, design of a new type of SE test rig has been proposed, which is simpler in construction and working. This newly designed test rig could possibly eliminate some of the limitations (velocity-concentration interdependence and lack of acceleration distance) found in the existing set-ups. Calibration of the test rig was done for jet velocity and erodent concentration. Commissioning of the rig was undertaken by evaluating the effect of operating parameters (concentration and impingement angle) on the erosion rates of aluminum and cast iron. Results show that the rig was able to capture the traditional responses of ductile and brittle erosion behaviors being observed for these materials. Repeatability of the test rig was ensured, and the results were found to be within the acceptable error limits.

  9. Match Rigging and the Career Concerns of Referees

    DEFF Research Database (Denmark)

    Severgnini, Battista; Boeri, Tito

    2011-01-01

    This paper contributes to the literature on career concerns and corruption by drawing on extensive information on the performance of referees and records from Calciopoli, a judicial inquiry carried out in 2006 on corruption in the Italian football league. Unlike previous studies, we can analyse...... in detail the assignment of the referees to the most important matches, which is an important step in their career. Moreover, we can relate this choice to the performance of referees in previous matches and the evaluations they received in this context. We find that referees involved in match rigging were...

  10. Stag rig Tibetan Village: Hair Changing and Marriage

    Directory of Open Access Journals (Sweden)

    'Brug mo skyid

    2010-12-01

    Full Text Available Marriage in Stag rig Village, Shar lung Township, Khri ka County, Mtsho lho Tibetan Autonomous Prefecture, Mtsho sngon Province, China is described in the context of the hair dressing ritual, rules of exclusion and inclusion, the process of marriage (spouse selection, free choice marriage, arranged marriage, engagement, drinking contract liquor, bride wealth discussion, choosing a date for the wedding ritual, wedding preparations at the bride and groom's homes, the wedding ritual and banquet, marrying a groom into the bride's home, divorce, and the atmosphere surrounding the bride's arrival.

  11. Rig safety depends on equipment, regulations, and personnel

    Energy Technology Data Exchange (ETDEWEB)

    Bates, T.R. Jr.; Tait, S. (Sedco Forex, Aberdeen (GB)); Mumford, G. (Sedco Forex, Montrouge (FR))

    1990-03-05

    The authors discuss how improvements that can increase rig safety can be made in equipment, regulations, and stabilized personnel levels. With regard to equipment, exposure to material handling must be reduced through automation, and well-control technology must be improved by enhanced use of computers and better systems to handle gas. According to this analysis, regulations are needed that are global in scope and have had their costs-to-benefits fully and fairly assessed. Self regulation must be used effectively throughout the industry. Job security and wages should be made adequate to maintain an experienced, motivated, and safe work force.

  12. Test Rig Design and Presentation for a Hydraulic Yaw System

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Andersen, Torben Ole

    2013-01-01

    dynamics under real conditions. The behavior of the system is analyzed with regard to 20 years of operation. This is for example done by applying loads from different design load cases, e.g. normal turbulence, extreme turbulence and different fault scenarios on the turbine. The paper first presents...... an introduction with the current state of the art and problem description, followed by a system description, where the system is designed and dimensioned. Based on the design, results from the test rig are presented and analyzed. Finally a conclusion summing up the design, model and test results is given....

  13. Metalearning to support competitive electricity market players' strategic bidding

    DEFF Research Database (Denmark)

    Pinto, Tiago; Sousa, Tiago M.; Morais, Hugo

    2016-01-01

    a dynamic artificial neural network to create its own output, taking advantage on several learning algorithms already implemented in ALBidS (Adaptive Learning strategic Bidding System). The proposed metalearner considers different weights for each strategy, based on their individual performance...

  14. 48 CFR 52.214-5 - Submission of Bids.

    Science.gov (United States)

    2010-10-01

    ... authorized by the solicitation. (e) Bids submitted by electronic commerce shall be considered only if the electronic commerce method was specifically stipulated or permitted by the solicitation. (End of provision) ... submitted by electronic means) (1) addressed to the office specified in the solicitation, and (2)...

  15. 27 CFR 72.68 - Sale on sealed, competitive bids.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Sale on sealed, competitive bids. 72.68 Section 72.68 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... PROPERTY Administrative Sale or Disposition of Personal Property § 72.68 Sale on sealed, competitive...

  16. 7 CFR 3560.504 - Sales price and bidding process.

    Science.gov (United States)

    2010-01-01

    ... 3560.504 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Management and Disposition of Real Estate Owned (REO) Properties § 3560.504 Sales price and bidding process. (a) The loan documents...

  17. Bidding for Nothing? The Pitfalls of overly Neutral Framing

    NARCIS (Netherlands)

    P. Dürsch (Peter); J. Müller (Julia)

    2014-01-01

    markdownabstract__Abstract__ Neutral framing is a standard tool of experimental economics. However, overly neutral instructions, which lack any contextual clues, can lead to strange behavior. In a contextless second price auction for a meaningless good, a majority of subjects enter positive bids -

  18. Application of fuzzy mathematics in assessment of mine design bidding

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Sen

    1988-12-01

    Assessment of mine design bidding is mainly to evaluate the quality of a mine design. The paper established a 3-stage model to assess quality of mine design using fuzzy criterion. A concept of assessment figures was proposed in the analysis of the results. Finally, a mine design was assessed. 2 refs., 2 figs., 1 tab.

  19. Mothers Respond Differently to Infants' Gestural versus Nongestural Communicative Bids

    Science.gov (United States)

    Olson, Janet; Masur, Elise Frank

    2013-01-01

    Thirty infants at 1;1 and their mothers were videotaped while playing for 18 minutes. Experimental stimuli were presented in three communicative intent contexts--proto-declarative, proto-imperative, and ambiguous--to elicit infant communicative bids that did and did not contain gestures. Mothers' responses were analyzed, and their verbal responses…

  20. Bidding Strategies in Agent-based Continuous Double Auctions

    NARCIS (Netherlands)

    Ma, H.; Leung, H.-F.

    2008-01-01

    Online auctions are a platform to trade goods on the Internet. In this context, negotiation capabilities for software agents in continuous double auctions (CDAs) are a central concern. Agents need to be able to prepare bids for and evaluate offers on behalf of the users they represent with the aim o

  1. Beijing won the bid for hosting the FISM 2009 Convention

    Institute of Scientific and Technical Information of China (English)

    陆定纲

    2006-01-01

    On August 4th, 2006, the fifth day of the 23rd FISM 2006 Convention in Stockholm. Beijing. after a fierce competition with the other two candidates-Granada and Vienna, finally won the bid for hosting FISM 2009 Convention, gaining 62 percent of the votes in the General Assembly.

  2. CHINA NATIONAL PETROLEUM CORPORATION Notice for Third Round of Bidding

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    @@ Authorized by the Government of the People's Republic of China, China National Petroleum Corporation (CNPC)hereby announces the commencement of the Third Round of Bidding for the Exploration of Land Petroleum Resources of P.R. China in Cooperation with Foreign Enterprises. 12 exploration blocks with a total area of 112 739 square kilometers are on offer.

  3. Integrated Bidding and Operating Strategies for Wind-Storage Systems

    DEFF Research Database (Denmark)

    Ding, Huajie; Pinson, Pierre; Hu, Zechun

    2016-01-01

    Due to their flexible charging and discharging capabilities, energy storage systems (ESS) are considered a promising complement to wind farms (WFs) participating in electricity markets. This paper presents integrated day-ahead bidding and real-time operation strategies for a wind-storage system...

  4. Optimal generator bidding strategies for power and ancillary services

    Science.gov (United States)

    Morinec, Allen G.

    As the electric power industry transitions to a deregulated market, power transactions are made upon price rather than cost. Generator companies are interested in maximizing their profits rather than overall system efficiency. A method to equitably compensate generation providers for real power, and ancillary services such as reactive power and spinning reserve, will ensure a competitive market with an adequate number of suppliers. Optimizing the generation product mix during bidding is necessary to maximize a generator company's profits. The objective of this research work is to determine and formulate appropriate optimal bidding strategies for a generation company in both the energy and ancillary services markets. These strategies should incorporate the capability curves of their generators as constraints to define the optimal product mix and price offered in the day-ahead and real time spot markets. In order to achieve such a goal, a two-player model was composed to simulate market auctions for power generation. A dynamic game methodology was developed to identify Nash Equilibria and Mixed-Strategy Nash Equilibria solutions as optimal generation bidding strategies for two-player non-cooperative variable-sum matrix games with incomplete information. These games integrated the generation product mix of real power, reactive power, and spinning reserve with the generators's capability curves as constraints. The research includes simulations of market auctions, where strategies were tested for generators with different unit constraints, costs, types of competitors, strategies, and demand levels. Studies on the capability of large hydrogen cooled synchronous generators were utilized to derive useful equations that define the exact shape of the capability curve from the intersections of the arcs defined by the centers and radial vectors of the rotor, stator, and steady-state stability limits. The available reactive reserve and spinning reserve were calculated given a

  5. Technical and economic evaluation of selected compact drill rigs for drilling 10,000 foot geothermal production wells

    Energy Technology Data Exchange (ETDEWEB)

    Huttrer, G.W. [Geothermal Management Company, Inc., Frisco, CO (United States)

    1997-11-01

    This report summarizes the investigation and evaluation of several {open_quotes}compact{close_quotes} drill rigs which could be used for drilling geothermal production wells. Use of these smaller rigs would save money by reducing mobilization costs, fuel consumption, crew sizes, and environmental impact. Advantages and disadvantages of currently-manufactured rigs are identified, and desirable characteristics for the {open_quotes}ideal{close_quotes} compact rig are defined. The report includes a detailed cost estimate of a specific rig, and an evaluation of the cost/benefit ratio of using this rig. Industry contacts for further information are given.

  6. Calibration of stereo rigs based on the backward projection process

    Science.gov (United States)

    Gu, Feifei; Zhao, Hong; Ma, Yueyang; Bu, Penghui; Zhao, Zixin

    2016-08-01

    High-accuracy 3D measurement based on binocular vision system is heavily dependent on the accurate calibration of two rigidly-fixed cameras. In most traditional calibration methods, stereo parameters are iteratively optimized through the forward imaging process (FIP). However, the results can only guarantee the minimal 2D pixel errors, but not the minimal 3D reconstruction errors. To address this problem, a simple method to calibrate a stereo rig based on the backward projection process (BPP) is proposed. The position of a spatial point can be determined separately from each camera by planar constraints provided by the planar pattern target. Then combined with pre-defined spatial points, intrinsic and extrinsic parameters of the stereo-rig can be optimized by minimizing the total 3D errors of both left and right cameras. An extensive performance study for the method in the presence of image noise and lens distortions is implemented. Experiments conducted on synthetic and real data demonstrate the accuracy and robustness of the proposed method.

  7. The U.S. Agency-Level Bid Protest Mechanism: A Model for Bid Challenge Procedures in Developing Nations

    Science.gov (United States)

    2005-08-31

    35 V. Bid Protest Procedures in the UNCITRAL Model Procurement Law and World Bank Development...Program...................................................................... 39 A. UNCITRAL Model Procurement Law...government procurement,5 and the assistance offered by the United Nations Committee on International Trade Law ( UNCITRAL )6 in the form of its Model Law

  8. Genetic algorithm evolution of utility bidding strategies for the competitive marketplace

    Energy Technology Data Exchange (ETDEWEB)

    Richter, C.W. Jr.; Sheble, G.B. [Iowa State Univ., Ames, IA (United States)

    1998-02-01

    This paper describes an environment in which distribution companies (discos) and generation companies (gencos), buy and sell power via double auctions implemented in a regional commodity exchange. The electric utilities` profits depend on the implementation of a successful bidding strategy. In this research, a genetic algorithm evolves bidding strategies as gencos and discos trade power. A framework in which bidding strategies may be tested and modified is presented. This simulated electric commodity exchange can be used off-line to predict whether bid strategies will be profitable and successful. It can also be used to experimentally verify how bidding behavior affects the competitive electric marketplace.

  9. The impact of competitive bidding on the market prospects for renewable electric technologies

    Energy Technology Data Exchange (ETDEWEB)

    Swezey, B G

    1993-09-01

    This report examines issues regarding the ability of renewable-energy-based generation projects to compete fossil-fuel-based projects in competitive bidding solicitations. State and utility bidding results revealed that on a relative basis, utilities contract for less renewable-energy-based capacity under competitive bidding than under past methods of qualifying facility contracting. It was concluded that renewables are not being chosen more often under competitive bidding because it emphasizes price and operating considerations over other attributes of renewables, such as environmental considerations, fuel diversity, and fuel price stability. Examples are given of bidding approaches used by some states and utilities that have resulted in renewables-based projects winning generation bids. In addition, the appendix summarizes, by state, competitive bidding activities and results for supply-side solicitations that were open to all fuels and technologies.

  10. An Insight into Spreadsheet User Behaviour through an Analysis of EuSpRIG Website Statistics

    CERN Document Server

    Croll, Grenville J

    2011-01-01

    The European Spreadsheet Risks Interest Group (EuSpRIG) has maintained a website almost since its inception in 2000. We present here longitudinal and cross-sectional statistics from the website log in order to shed some light upon end-user activity in the EuSpRIG domain.

  11. Testing of a new morphing trailing edge flap system on a novel outdoor rotating test rig

    DEFF Research Database (Denmark)

    Aagaard Madsen, Helge; Barlas, Athanasios; Løgstrup Andersen, Tom

    2015-01-01

    manufacturing and application. To narrow the gap between wind tunnel testing and full scale prototype testing we developed the rotating test rig. The overall objectives with the rotating test rig are: 1) to test the flap system in a realistic rotating environment with a realistic g-loading; 2) to measure...

  12. A reciprocating pin-on-plate test-rig for studying friction materials for holding brakes

    DEFF Research Database (Denmark)

    Poulios, Konstantinos; Drago, Nicola; Klit, Peder

    2014-01-01

    -on-plate test-rig for studying the evolution of wear by monitoring the pin height reduction using Eddy-current proximity sensors is presented. Moreover, a new mechanism for recording the friction force is suggested. Apart from the design of the test-rig, friction force and wear rate measurements for two...

  13. A Universal Rig for Supporting Large Hammer Drills: Reduced Injury Risk and Improved Productivity

    Science.gov (United States)

    Rempel, David; Barr, Alan

    2015-01-01

    Drilling holes into concrete with heavy hammer and rock drills is one of the most physically demanding tasks performed in commercial construction and poses risks for musculoskeletal disorders, noise induced hearing loss, hand arm vibration syndrome and silicosis. The aim of this study was to (1) use a participatory process to develop a rig to support pneumatic rock drills or large electric hammer drills in order to reduce the health risks and (2) evaluate the usability of the rig. Seven prototype rigs for supporting large hammer drills were developed and modified with feedback from commercial contractors and construction workers. The final design was evaluated by laborers and electricians (N=29) who performed their usual concrete drilling with the usual method and the new rig. Subjective regional fatigue was significantly less in the neck, shoulders, hands and arms, and lower back) when using the universal rig compared to the usual manual method. Usability ratings for the rig were significantly better than the usual method on stability, control, drilling, accuracy, and vibration. Drilling time was reduced by approximately 50% with the rig. Commercial construction contractors, laborers and electricians who use large hammer drills for drilling many holes should consider using such a rig to prevent musculoskeletal disorders, fatigue, and silicosis. PMID:26005290

  14. Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Na-Rae; Shin, Han-Bo; Kim, Hye-In; Choi, Myung-Soo; Inn, Kyung-Soo, E-mail: innks@khu.ac.kr

    2013-07-19

    Highlights: •TRK-fused gene product (TFG) interacts with TRIM25 upon viral infection. •TFG negatively regulates RIG-I mediated antiviral signaling. •TFG depletion leads to enhanced viral replication. •TFG act downstream of MAVS. -- Abstract: RIG-I (retinoic acid inducible gene I)-mediated antiviral signaling serves as the first line of defense against viral infection. Upon detection of viral RNA, RIG-I undergoes TRIM25 (tripartite motif protein 25)-mediated K63-linked ubiquitination, leading to type I interferon (IFN) production. In this study, we demonstrate that TRK-fused gene (TFG) protein, previously identified as a TRIM25-interacting protein, binds TRIM25 upon virus infection and negatively regulates RIG-I-mediated type-I IFN signaling. RIG-I-mediated IFN production and nuclear factor (NF)-κB signaling pathways were upregulated by the suppression of TFG expression. Furthermore, vesicular stomatitis virus (VSV) replication was significantly inhibited by small inhibitory hairpin RNA (shRNA)-mediated knockdown of TFG, supporting the suppressive role of TFG in RIG-I-mediated antiviral signaling. Interestingly, suppression of TFG expression increased not only RIG-I-mediated signaling but also MAVS (mitochondrial antiviral signaling protein)-induced signaling, suggesting that TFG plays a pivotal role in negative regulation of RNA-sensing, RIG-I-like receptor (RLR) family signaling pathways.

  15. A Universal Rig for Supporting Large Hammer Drills: Reduced Injury Risk and Improved Productivity.

    Science.gov (United States)

    Rempel, David; Barr, Alan

    2015-10-01

    Drilling holes into concrete with heavy hammer and rock drills is one of the most physically demanding tasks performed in commercial construction and poses risks for musculoskeletal disorders, noise induced hearing loss, hand arm vibration syndrome and silicosis. The aim of this study was to (1) use a participatory process to develop a rig to support pneumatic rock drills or large electric hammer drills in order to reduce the health risks and (2) evaluate the usability of the rig. Seven prototype rigs for supporting large hammer drills were developed and modified with feedback from commercial contractors and construction workers. The final design was evaluated by laborers and electricians (N=29) who performed their usual concrete drilling with the usual method and the new rig. Subjective regional fatigue was significantly less in the neck, shoulders, hands and arms, and lower back) when using the universal rig compared to the usual manual method. Usability ratings for the rig were significantly better than the usual method on stability, control, drilling, accuracy, and vibration. Drilling time was reduced by approximately 50% with the rig. Commercial construction contractors, laborers and electricians who use large hammer drills for drilling many holes should consider using such a rig to prevent musculoskeletal disorders, fatigue, and silicosis.

  16. Nonlinear Control for Magnetic Bearings in Deployment Test Rigs : Simulation and Experimental Results

    NARCIS (Netherlands)

    Scherpen, J.M.A.; Kerk, B. van der; Klaassens, J.B.; Lazeroms, M.; Kan, S.Y.

    1998-01-01

    In this paper three control schemes for a test set-up of a magnetic bearing system for deployment rigs of solar arrays are described. The air gap of the magnet has to be controlled to a constant value independent of the deployment of the solar array. The deployment of the rig has been modeled as a v

  17. RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.

    Directory of Open Access Journals (Sweden)

    Matheswaran Kandasamy

    2016-07-01

    Full Text Available Retinoic acid inducible gene-I (RIG-I is an innate RNA sensor that recognizes the influenza A virus (IAV RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism and regulating host immune responses. Mice deficient in the RIG-I-MAVS pathway show defects in migratory dendritic cell (DC activation, viral antigen presentation, and priming of CD8+ and CD4+ T cell responses during IAV infection. These defects result in decreased frequency of polyfunctional effector T cells and lowered protection against heterologous IAV challenge. In addition, our data show that RIG-I activation is essential for protecting epithelial cells and hematopoietic cells from IAV infection. These diverse effects of RIG-I signaling are likely imparted by the actions of type I interferon (IFN, as addition of exogenous type I IFN is sufficient to overcome the defects in antigen presentation by RIG-I deficient BMDC. Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 -MAVS via poly I:C treatment. Taken together, these findings demonstrate that RIG-I signaling through MAVS is critical for determining the quality of polyfunctional T cell responses against IAV and for providing protection against subsequent infection from heterologous or novel pandemic IAV strains.

  18. RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection

    Science.gov (United States)

    Kandasamy, Matheswaran; Suryawanshi, Amol; Tundup, Smanla; Perez, Jasmine T.; Schmolke, Mirco; Manicassamy, Santhakumar; Manicassamy, Balaji

    2016-01-01

    Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism and regulating host immune responses. Mice deficient in the RIG-I-MAVS pathway show defects in migratory dendritic cell (DC) activation, viral antigen presentation, and priming of CD8+ and CD4+ T cell responses during IAV infection. These defects result in decreased frequency of polyfunctional effector T cells and lowered protection against heterologous IAV challenge. In addition, our data show that RIG-I activation is essential for protecting epithelial cells and hematopoietic cells from IAV infection. These diverse effects of RIG-I signaling are likely imparted by the actions of type I interferon (IFN), as addition of exogenous type I IFN is sufficient to overcome the defects in antigen presentation by RIG-I deficient BMDC. Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 –MAVS via poly I:C treatment. Taken together, these findings demonstrate that RIG-I signaling through MAVS is critical for determining the quality of polyfunctional T cell responses against IAV and for providing protection against subsequent infection from heterologous or novel pandemic IAV strains. PMID:27438481

  19. Dynamic Investigation Test-rig on hAptics (DITA)

    Science.gov (United States)

    Cannella, F.; Scalise, L.; Olivieri, E.; Memeo, M.; Caldwell, D. G.

    2013-09-01

    Research on tactile sensitivity has been conducted since the last century and many devices have been proposed to study in detail this sense through experimental tests. The sense of touch is essential in every-day life of human beings, but it can also play a fundamental role for the assessment of some neurological disabilities and pathologies. In fact, the level of tactile perception can provide information on the health state of the nervous system. In this paper, authors propose the design and development of a novel test apparatus, named DITA (Dynamic Investigation Test-rig on hAptics), aiming to provide the measurement of the tactile sensitivity trough the determination of the Just Noticeable Difference (JND) curve of a subject. The paper reports the solution adopted for the system design and the results obtained on the set of experiments carried out on volunteers.

  20. Valuing the Environment Via Bidding Games: A Psychological Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Hebert, J. A.; Shikiar, R.; Perry, R. W.

    1980-08-01

    How to place a monetary value on the environment and manmade environmental change represents a major methodological problem. The merits of using a monetary scale for valuing environmental goods are that it is familiar to all, can be related to wealth, and, if successfully implemented, can be combined with monetary information from actual costs. Assigning monetary values to "goods" not bought and sold in the marketplace is difficult at best. Several methods are available: direct costing, indirect costing, and bidding games. Direct costs measure the cost of damages associated with environmental change. Indirect costs measure values associated with environmental change (e.g., change in property values). Neither are seen as adequate for measuring net or aggregate social value for public policy decisions. Bidding games are seen as the most appropriate method. Based on the concept of consumer surplus, bidding games are said to measure the maximum willingness to pay (WTP) for a good (e.g., environmental change). Four valid games can be played: 1) WTP to get a positive environmental change; 2) WTP to prevent a negative environmental change; 3) minimum willingness to accept (WTA) in compensation to forego a positive environmental change; and 4) WTA to put up with a negative environmental change. Close examination of the assumptions of these games reveals two important considerations: perceived rights and perceived positive or negative nature of the proposed change. For example, if a respondent is asked to state his/her maximum WTP to prevent the construction of a power plant, the game is valid only if 1) the respondent agrees that he/she has no right to the current state and has to "purchase" the right, and 2) that the construction is perceived by the respondent as a negative change. Many environmental changes are, in fact, ambiguous with respect to rights and positive or negative quality. This is often the case across a sample of area residents. Forcing the respondent to

  1. Bay Area Council Announce Bid for 2020 World Expo

    Institute of Scientific and Technical Information of China (English)

    Audrey

    2010-01-01

    @@ During his visit in Shanghai in September, Governor Arnold Schwarzenegger joined Bay Area Council President & CEO Jim Wunderman to announce that California will bid to host the 2020 World Expo in Silicon Valley. The announcement was made at the World Expo in Shanghai before the Governor toured the U.S., Austrian and Chinese pavilions. World Expos typically occur every five years and at-tract exhibits from countries around the globe and bring as many as 770 million visitors.

  2. On bid-price controls for network revenue management

    Directory of Open Access Journals (Sweden)

    Bariş Ata

    2015-12-01

    Full Text Available We consider a network revenue management problem and advance its dual formulation. The dual formulation reveals that the (optimal shadow price of capacity forms a nonnegative martingale. This result is proved under minimal assumptions on network topology and stochastic nature of demand, allowing an arbitrary statistical dependence structure across time and products. Next, we consider a quadratic perturbation of the network revenue management problem and show that a simple (perturbed bid-price control is optimal for the perturbed problem; and it is ε-optimal for the original network revenue management problem. Finally, we consider a predictable version of this control, where the bid prices used in the current period are last updated in the previous period, and provide an upper bound on its optimality gap in terms of the (quadratic variation of demand. Using this upper bound we show that there exists a near-optimal such control in the usual case when periods are small compared to the planning horizon provided that either demand or the incremental information arriving during each period is small. We establish the martingale property of the (near optimal bid prices in both settings. The martingale property can have important implications in practice as it may offer a tool for monitoring the revenue management systems.

  3. Fluorescence Resonance Energy Transfer Analysis of Bid Activation in Living Cells during Ultraviolet-induced Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Yinyuan WU; Da XING; Lei LIU; Tongsheng CHEN; Wei R. CHEN

    2007-01-01

    Ultraviolet (UV) irradiation is a DNA-damaging agent that triggers apoptosis through both the membrane death receptor and mitochondrial apoptotic signaling pathways. Bid, a pro-apoptotic Bcl-2family member, is important in most cell types to apoptosis in response to DNA damage. In this study, a recombinant plasmid, YFP-Bid-CFP, comprised of yellow and cyan fluorescent protein and a full length Bid,was used as a fluorescence resonance energy transfer analysis (FRET) probe. Using the FRET technique based on YFP-Bid-CFP, we found that Bid activation was initiated at 9±1 h after UV irradiation, and the average duration of the activation was 75± 10 min. Bid activation coincided with a collapse of the mitochondrial membrane potential with an average duration of 50±10 min. When cells were pretreated with Z-IETD-fmk(caspase-8 specific inhibitor) the process of Bid activation was completely inhibited, but the apoptosis was only partially affected. Z-DEVD-fmk (caspase-3 inhibitor) and Z-FA-fmk (non asp specific inhibitor) did not block Bid activation. Furthermore, the endogenous Bid activation with or without Z-IETD-fmk in response to UV irradiation was confirmed by Western blotting. In summary, using the FRET technique, we observed the dynamics of Bid activation during UV-induced apoptosis and found that it was a caspase-8 dependent event.

  4. Bid, a Widely Expressed Proapoptotic Protein of the Bcl-2 Family, Displays Lipid Transfer Activity

    Science.gov (United States)

    Esposti, Mauro Degli; Erler, Janine T.; Hickman, John A.; Dive, Caroline

    2001-01-01

    Bid is an abundant proapoptotic protein of the Bcl-2 family that is crucial for the induction of death receptor-mediated apoptosis in primary tissues such as liver. Bid action has been proposed to involve the relocation of its truncated form, tBid, to mitochondria to facilitate the release of apoptogenic cytochrome c. The mechanism of Bid relocation to mitochondria was unclear. We report here novel biochemical evidence indicating that Bid has lipid transfer activity between mitochondria and other intracellular membranes, thereby explaining its dynamic relocation to mitochondria. First, physiological concentrations of phospholipids such as phosphatidic acid and phosphatidylgycerol induced an accumulation of full-length Bid in mitochondria when incubated with light membranes enriched in endoplasmic reticulum. Secondly, native and recombinant Bid, as well as tBid, displayed lipid transfer activity under the same conditions and at the same nanomolar concentrations leading to mitochondrial relocation and release of cytochrome c. Thus, Bid is likely to be involved in the transport and recycling of mitochondrial phospholipids. We discuss how this new role of Bid may relate to its proapoptotic action. PMID:11585909

  5. RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection.

    Directory of Open Access Journals (Sweden)

    Arshed Nazmi

    Full Text Available BACKGROUND: Neuroinflammation associated with Japanese encephalitis (JE is mainly due to the activation of glial cells with subsequent release of proinflammatory mediators from them. The recognition of viral RNA, in part, by the pattern recognition receptor retinoic acid-inducible gene I (RIG-I has been indicated to have a role in such processes. Even though neurons are also known to express this receptor, its role after JE virus (JEV infections is yet to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS: Upon infecting murine neuroblastoma cells and primary cortical neurons with JEV the expression profile of key proinflammatory cyto/chemokines were analyzed by qRT-PCR and bead array, both before and after ablation of RIG-I. Immunoblotting was performed to evaluate the levels of key molecules downstream to RIG-I leading to production of proinflammatory mediators. Changes in the intracellular viral antigen expression were confirmed by intracellular staining and immunoblotting. JEV infection induced neuronal expression of IL-6, IL-12p70, MCP-1, IP-10 and TNF-α in a time-dependent manner, which showed significant reduction upon RIG-I ablation. Molecules downstream to RIG-I showed significant changes upon JEV-infection, that were modulated following RIG-I ablation. Ablation of RIG-I in neurons also increased their susceptibility to JEV. CONCLUSIONS/SIGNIFICANCE: In this study we propose that neurons are one of the potential sources of proinflammatory cyto/chemokines in JEV-infected brain that are produced via RIG-I dependent pathways. Ablation of RIG-I in neurons leads to increased viral load and reduced release of the cyto/chemokines.

  6. Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV

    Directory of Open Access Journals (Sweden)

    Wenping Xu

    2015-07-01

    Full Text Available Retinoic acid-inducible gene I (RIG-I, a cytosolic pattern recognition receptor (PRR, can sense various RNA viruses, including the avian influenza virus (AIV and infectious bursal disease virus (IBDV, and trigger the innate immune response. Previous studies have shown that mammalian RIG-I (human and mice and waterfowl RIG-I (ducks and geese are essential for type I interferon (IFN synthesis during AIV infection. Like ducks, pigeons are also susceptible to infection but are ineffective propagators and disseminators of AIVs, i.e., “dead end” hosts for AIVs and even highly pathogenic avian influenza (HPAI. Consequently, we sought to identify pigeon RIG-I and investigate its roles in the detection of A/Chicken/Shandong/ZB/2007 (H9N2 (ZB07, Gansu/Tianshui (IBDV TS and Beijing/CJ/1980 (IBDV CJ-801 strains in chicken DF-1 fibroblasts or human 293T cells. Pigeon mRNA encoding the putative pigeon RIG-I analogs was identified. The exogenous expression of enhanced green fluorescence protein (EGFP-tagged pigeon RIG-I and caspase activation and recruitment domains (CARDs, strongly induced antiviral gene (IFN-β, Mx, and PKR mRNA synthesis, decreased viral gene (M gene and VP2 mRNA expression, and reduced the viral titers of ZB07 and IBDV TS/CJ-801 virus strains in chicken DF-1 cells, but not in 293T cells. We also compared the antiviral abilities of RIG-I proteins from waterfowl (duck and goose and pigeon. Our data indicated that waterfowl RIG-I are more effective in the induction of antiviral genes and the repression of ZB07 and IBDV TS/CJ-801 strain replication than pigeon RIG-I. Furthermore, chicken melanoma differentiation associated gene 5(MDA5/ mitochondrial antiviral signaling (MAVS silencing combined with RIG-I transfection suggested that pigeon RIG-I can restore the antiviral response in MDA5-silenced DF-1 cells but not in MAVS-silenced DF-1 cells. In conclusion, these results demonstrated that pigeon RIG-I and CARDs have a strong antiviral

  7. Full Length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

    Directory of Open Access Journals (Sweden)

    Ward Manus W

    2007-02-01

    Full Text Available Abstract Background Bcl-2 homology domain (BH 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to the mitochondrial cell death pathways. The BH3-only protein Bid can be activated in response to death receptor activation via caspase 8-mediated cleavage into a truncated protein (tBid, which subsequently translocates to mitochondria and induces the release of cytochrome-C. Using a single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that, in contrast to death receptor-induced apoptosis, caspase-independent excitotoxic apoptosis involves a translocation of full length Bid (FL-Bid from the cytosol to mitochondria. We induced a delayed excitotoxic cell death in cultured rat hippocampal neurons by a 5-min exposure to the glutamate receptor agonist N-methyl-D-aspartate (NMDA; 300 μM. Results Western blot experiments confirmed a translocation of FL-Bid to the mitochondria during excitotoxic apoptosis that was associated with the release of cytochrome-C from mitochondria. These results were confirmed by immunofluorescence analysis of Bid translocation during excitotoxic cell death using an antibody raised against the amino acids 1–58 of mouse Bid that is not able to detect tBid. Finally, inducible overexpression of FL-Bid or a Bid mutant that can not be cleaved by caspase-8 was sufficient to induce apoptosis in the hippocampal neuron cultures. Conclusion Our data suggest that translocation of FL-Bid is sufficient for the activation of mitochondrial cell death pathways in response to glutamate receptor overactivation.

  8. Auctioning Process Innovations when Losers’ Bids Determine Royalty Rates

    OpenAIRE

    Fan, Cuihong; Jun, Byoung Heon; Elmar G. Wolfstetter

    2009-01-01

    We consider a licensing mechanism for process innovations that combines a license auction with royalty contracts to those who lose the auction. Firms’ bids are dual signals of their cost reductions: the winning bid signals the own cost reduction to rival oligopolists, whereas the losing bid influences the beliefs of the innovator who uses that information to set the royalty rate. We derive conditions for existence of a separating equilibrium, explain why a sufficiently high reserve price is...

  9. Research Note--Strategic Bid-Shading and Sequential Auctioning with Learning from Past Prices

    OpenAIRE

    Robert Zeithammer

    2007-01-01

    This paper analyzes sequential auctioning of single units of an indivisible good to a fluctuating population composed of overlapping generations of unit-demand bidders. Two phenomena emergent in such a market are investigated: forward-looking bidding strategies, and closed-loop selling strategies that involve learning from past prices. The buyers shade their bids down, i.e., bid less than they would in a single isolated auction, whenever they expect the seller to sell another unit of the good...

  10. Regulation of Retinoic Acid Inducible Gene-I (RIG-I Activation by the Histone Deacetylase 6

    Directory of Open Access Journals (Sweden)

    Helene Minyi Liu

    2016-07-01

    Full Text Available Retinoic acid inducible gene-I (RIG-I is a cytosolic pathogen recognition receptor that initiates the immune response against many RNA viruses. Upon RNA ligand binding, RIG-I undergoes a conformational change facilitating its homo-oligomerization and activation that results in its translocation from the cytosol to intracellular membranes to bind its signaling adaptor protein, mitochondrial antiviral-signaling protein (MAVS. Here we show that RIG-I activation is regulated by reversible acetylation. Acetyl-mimetic mutants of RIG-I do not form virus-induced homo-oligomers, revealing that acetyl-lysine residues of the RIG-I repressor domain prevent assembly to active homo-oligomers. During acute infection, deacetylation of RIG-I promotes its oligomerization upon ligand binding. We identify histone deacetylase 6 (HDAC6 as the deacetylase that promotes RIG-I activation and innate antiviral immunity to recognize and restrict RNA virus infection.

  11. Stochastic programming of drilling rigs supplies; Programacao estocastica de suprimentos de sondas

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Bruno Ferreira; Ferreira Filho, Virgilio Jose Martins [Coordenacao dos Programas de Pos-Graduacao de Engenharia (COPPE/UFRJ), RJ (Brazil)

    2012-07-01

    The goal of this work is to use techniques of stochastic programming to reduce logistic costs regarding offshore drilling rigs. This theme is of great interest to Brazilian oil industry since there is an increasing number of wells that need to be perforated so that Brazilian oil production can reach its expected growth over the next ten years (PETROBRAS in particular has an ambitious strategy in this respect). Proper treatment of the uncertainties involved in the deliveries of supplies to offshore drilling rigs is essential, namely, these uncertainties need to be included in the models used in logistic models. Delays in the deliveries of products such as chemicals, perforation fluids and tubes may force drilling rigs to stop their operations what highly increases costs. The daily hiring rates of drilling rigs represent the highest cost in the perforation and completion of a well. (author)

  12. Development of a low cost test rig for standalone WECS subject to electrical faults.

    Science.gov (United States)

    Himani; Dahiya, Ratna

    2016-11-01

    In this paper, a contribution to the development of low-cost wind turbine (WT) test rig for stator fault diagnosis of wind turbine generator is proposed. The test rig is developed using a 2.5kW, 1750 RPM DC motor coupled to a 1.5kW, 1500 RPM self-excited induction generator interfaced with a WT mathematical model in LabVIEW. The performance of the test rig is benchmarked with already proven wind turbine test rigs. In order to detect the stator faults using non-stationary signals in self-excited induction generator, an online fault diagnostic technique of DWT-based multi-resolution analysis is proposed. It has been experimentally proven that for varying wind conditions wavelet decomposition allows good differentiation between faulty and healthy conditions leading to an effective diagnostic procedure for wind turbine condition monitoring.

  13. Endoscopic PIV measurements in a low pressure turbine rig

    Energy Technology Data Exchange (ETDEWEB)

    Kegalj, Martin; Schiffer, Heinz-Peter [Technische Universitaet Darmstadt (Germany). Department of Gas Turbines and Aerospace Propulsion

    2009-10-15

    Particle-Image-Velocimetry (PIV) is a useful way to acquire information about the flow in turbomachinery. Several premises have to be fulfilled to achieve high-quality data, for example, optical access, low vibrations and low reflections. However, not all test facilities comply with these requirements. If there is no optical access to the test area, measurements cannot be performed. The use of borescopic optics is a possible solution to this issue, as the access required is very small. Several different techniques can be used to measure the three components of the velocity vector, one of which is Stereo-PIV. These techniques require either large optical access from several viewing angles or highly complex setups. Orthogonal light sheet orientations in combination with borescopic optics using Planar-PIV can deliver sufficient information about the flow. This study will show the feasibility of such an approach in an enclosed test area, such as the interblade space in a Low-Pressure-Turbine-Rig. The results from PIV will be compared with data collected with conventional techniques, such as the Five-Hole-Probe and the 2-component Hot-Wire-Anemometry. An analysis of time- and phase-averaged data will be performed. (orig.)

  14. Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin.

    Directory of Open Access Journals (Sweden)

    Domingo Miranzo-Navarro

    Full Text Available Retinoic acid inducible gene I (RIG-I is a viral RNA sensor crucial in defense against several viruses including measles, influenza A and hepatitis C. RIG-I activates type-I interferon signalling through the adaptor for mitochondrial antiviral signaling (MAVS. The E3 ubiquitin ligase, tripartite motif containing protein 25 (TRIM25, activates human RIG-I through generation of anchored K63-linked polyubiquitin chains attached to lysine 172, or alternatively, through the generation of unanchored K63-linked polyubiquitin chains that interact non-covalently with RIG-I CARD domains. Previously, we identified RIG-I of ducks, of interest because ducks are the host and natural reservoir of influenza viruses, and showed it initiates innate immune signaling leading to production of interferon-beta (IFN-β. We noted that K172 is not conserved in RIG-I of ducks and other avian species, or mouse. Because K172 is important for both mechanisms of activation of human RIG-I, we investigated whether duck RIG-I was activated by TRIM25, and if other residues were the sites for attachment of ubiquitin. Here we show duck RIG-I CARD domains are ubiquitinated for activation, and ubiquitination depends on interaction with TRIM25, as a splice variant that cannot interact with TRIM25 is not ubiquitinated, and cannot be activated. We expressed GST-fusion proteins of duck CARD domains and characterized TRIM25 modifications of CARD domains by mass spectrometry. We identified two sites that are ubiquitinated in duck CARD domains, K167 and K193, and detected K63 linked polyubiquitin chains. Site directed mutagenesis of each site alone, does not alter the ubiquitination profile of the duck CARD domains. However, mutation of both sites resulted in loss of all attached ubiquitin and polyubiquitin chains. Remarkably, the double mutant duck RIG-I CARD still interacts with TRIM25, and can still be activated. Our results demonstrate that anchored ubiquitin chains are not necessary for

  15. Expression of Bcl-2 Family Member Bid in Normal and Malignant Tissues

    Directory of Open Access Journals (Sweden)

    Maryla Krajewska

    2002-01-01

    Full Text Available Bid is the only known Bcl-2 family member that can function as an agonist of proapoptotic Bcl-2-related proteins such as Bax and Bak. Expression of the proapoptotic Bcl-2 family protein Bid was assessed by immunoblotting and immunohistochemical methods in normal murine and human tissues, and in several types of human cancers and tumor cell lines. Bid expression in normal tissues varied widely, with prominent Bid immunostaining occurring in several types of short-lived cells (e.g., germinal center B cells, peripheral blood granulocytes, differentiated keratinocytes and in apoptosissensitive cells (e.g., adult neurons. Analysis of Bid expression by immunostaining of 100 colon, 95 ovarian, and 254 prostate cancers, as well as 59 brain tumors and 50 lymphomas, revealed evidence of altered Bid regulation in sometypes of cancers. Correlations with clinical outcome data revealed association of higher levels of Bid with longer recurrence-free survival in men with locally advanced (T3 stage prostate cancer (P=0.04. Immunoblot analysis of Bid protein levels in the NCI's panel of 60 human tumor cell lines revealed a correlation between higher levels of Bid and sensitivity to ribonucleotide reductase (RR-inhibiting drugs (P<0.0005. Overexpression of Bid in a model tumor cell line by gene transfection resulted in increased sensitivity to apoptosis induction by a RR inhibitor. Taken together, these observations suggest a potential role for Bid in tumor responses to specific chemotherapeutic drugs, and lay a foundation for future investigations of this member of the Bcl-2 family in healthy and diseased tissues.

  16. Test rig for investigations of force excited and synchrocoupling loaded rotor

    Science.gov (United States)

    Rauch, Adam

    1987-10-01

    The main topics of test rig based rotor investigations are: dynamic relations of a rotor bearing foundation system, shaft cracking, torsional simulation of rotor-generator hunting, flexural-torsional coupling of vibrations, and other areas of rotor dynamics including balancing, maintenance and modal analysis of a rotor. The present paper describes a general purpose rotor test rig capable of handling a great number of these areas. The test rig simulates a heavy, power-loaded rotor mounted on a flexible foundation. Five forms of excitation are provided: oscillating or impact torque, impact force, step force, bearing and foundation excitation. They can be combined if necessary. New research facilities offered by the rig are: external flexural force loading, driving torque loading by synchrocoupling with a full recovery of brake energy, bending release of rotor ends by pivoting, and multi-pulse impact force excitation. The most remarkable is the synchroaxle principle, called SAP for short, which is described in detail. Test rig features have been proved to be successful by research of shaft cracking and rotor-foundation vibrations. This presentation concerns only the general description, calculation and application aspects of the rig.

  17. Into the deep : Seabed Rig could help reduce risks in the Arctic

    Energy Technology Data Exchange (ETDEWEB)

    Macedo, R.

    2009-12-15

    According to the United States Geological Survey, the Arctic accounts for 13 per cent of the world's undiscovered oil, 30 per cent of the natural gas and 20 per cent of the natural gas liquids. Approximately 84 per cent of the estimated resources are expected to be offshore in harsh physical environments. A Norwegian company is designing a rig that will avoid problems associated with floating ice, icebergs and sub-zero temperatures. The unmanned Seabed Rig AS drilling rig will sit on the ocean floor. Automated and robotized working operations will be controlled remotely from an interactive 3D interface connected to the vessel through an umbilical. The umbilical with power control and mud flow can be disconnected in the event of an emergency, allowing the vessel to abandon the area. Supporters of the technology include Statoil ASA, Convexa, iPark AS, the Norwegian Research Council and Innovasjon Norge. An interactive, computer generated 3-dimensional model will be produced to view the entire rig remotely. Each subsea control system will send continuous feedback to the visualizator, which updates the 3D model in real time on a big screen. Although the rig is suited for operation in Arctic areas and deep waters, it could also be used in traditional drilling. A full-scale prototype of the core of the technology is being developed. The Seabed Rig will require fewer operating personnel and standby vessels. 1 ref., 2 figs.

  18. Simulation of Fluid Flows through the Irradiation Test Rig for DUPIC Mini-element

    Energy Technology Data Exchange (ETDEWEB)

    Park, Joo Hwan; Yoon, Churl; Lee, Chul Yong; Song, Kee Chan

    2006-02-15

    The flow characteristic of the irradiation test rigs has been investigated by using a commercial CFD code, CFX-5.7(Ansys Inc.). The test rigs had been developed and fabricated to irradiate the DUPIC mini-elements in the HANARO research reactor of the Korea Atomic Energy Research Institute. First, the fluid flow through the DUPIC-2 test rig was calculated and compared with an experimental data. The computed pressure drops across the DUPIC-2 test rig match well with the experimental data. Then, a CFD analysis has been performed for the fluid flow through the newly-designed DUPIC-6 test rig. As results of the prediction, it is estimated that the mass flow rate is 8.0 kg/s under the pressure drop across the DUPIC-6 test rig of 215.5 kPa. The corresponding the maximum vibration displacement is expected to be around 50 {open_square}m, which satisfies the license limit with large margin.

  19. Preventing conflicts among bid curves used with transactive controllers in a market-based resource allocation system

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, Jason C.; Chassin, David P.; Pratt, Robert G.; Hauer, Matthew; Tuffner, Francis K.

    2017-03-07

    Disclosed herein are representative embodiments of methods, apparatus, and systems for distributing a resource (such as electricity) using a resource allocation system. One of the disclosed embodiments is a method for operating a transactive thermostatic controller configured to submit bids to a market-based resource allocation system. According to the exemplary method, a first bid curve is determined, the first bid curve indicating a first set of bid prices for corresponding temperatures and being associated with a cooling mode of operation for a heating and cooling system. A second bid curve is also determined, the second bid curve indicating a second set of bid prices for corresponding temperatures and being associated with a heating mode of operation for a heating and cooling system. In this embodiment, the first bid curve, the second bid curve, or both the first bid curve and the second bid curve are modified to prevent overlap of any portion of the first bid curve and the second bid curve.

  20. CFD-Guided Development of Test Rigs for Studying Erosion and Large-Particle Damage of Thermal Barrier Coatings

    Directory of Open Access Journals (Sweden)

    Maria A. Kuczmarski

    2011-01-01

    Full Text Available Burner rigs are routinely used to qualify materials for gas turbine applications. The most useful rig tests are those that can replicate, often in an accelerated manner, the degradation that materials experience in the engine. Computational fluid dynamics (CFD can be used to accelerate the successful development and continuous improvement of combustion burner rigs for meaningful materials testing. Rig development is typically an iterative process of making incremental modifications to improve the rig performance for testing requirements. Application of CFD allows many of these iterations to be done computationally before hardware is built or modified, reducing overall testing costs and time, and it can provide an improved understanding of how these rigs operate. This paper describes the use of CFD to develop burner test rigs for studying erosion and large-particle damage of thermal barrier coatings (TBCs used to protect turbine blades from high heat fluxes in combustion engines. The steps used in this study—determining the questions that need to be answered regarding the test rig performance, developing and validating the model, and using it to predict rig performance—can be applied to the efficient development of other test rigs.

  1. On low bidding price in construction project bidding%对建设工程招投标中低价竞标的探讨

    Institute of Scientific and Technical Information of China (English)

    司宏卫

    2009-01-01

    根据我国建筑行业招投标的现状,阐述了实行低价竞标的利弊,分析了造成低于成本价竞标的原因,并提出了关于招投标工作的几点建议,从而使建筑企业获取一定的合理利润,促进整个建筑业健康发展.%According to the current situation of Chinese construction industry bidding, the author describes the advantages and disadvantages of carrying out low bidding price, analyzes the causes of bidding with price lower than cost price, and provides some suggestions about bidding work, thus making the construction enterprise get certain reasonable benefit and promoting the healthy development of whole construction industry.

  2. Comprehensive bidding strategies with genetic programming/finite state automata

    Energy Technology Data Exchange (ETDEWEB)

    Richter, C.W. Jr.; Sheble, G.B.; Ashlock, D.

    1999-11-01

    This research is an extension of the authors' previous work in double auctions aimed at developing bidding strategies for electric utilities which trade electricity competitively. The improvements detailed in this paper come from using data structures which combine genetic programming and finite state automata termed GP-Automata. The strategies developed by the method described here are adaptive--reacting to inputs--whereas the previously developed strategies were only suitable in the particular scenario for which they had been designed. The strategies encoded in the GP-Automata are tested in an auction simulator. The simulator pits them against other distribution companies (distcos) and generation companies (gencos), buying and selling power via double auctions implemented in regional commodity exchanges. The GP-Automata are evolved with a genetic algorithm so that they possess certain characteristics. In addition to designing successful bidding strategies (whose usage would result in higher profits) the resulting strategies can also be designed to imitate certain types of trading behaviors. The resulting strategies can be implemented directly in on-line trading, or can be used as realistic competitors in an off-line trading simulator.

  3. Strategic Bidding in Multi-Unit Auctions with Capacity Constrained Bidders

    DEFF Research Database (Denmark)

    Schwenen, Sebastian

    2015-01-01

    This article employs a simple model to describe bidding behavior in multi-unit uniform price procurement auctions when firms are capacity constrained. Using data from the New York City procurement auctions for power generating capacity, I find that firms use simple bidding strategies to coordinate...

  4. Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.

    Science.gov (United States)

    Liu, Y; Aiello, A; Zinkel, S S

    2012-10-01

    Hematopoietic stem cells (HSCs) possess long-term self-renewal capacity and multipotent differentiative capacity, to maintain the hematopoietic system. Long-term hematopoietic homeostasis requires effective control of genotoxic damage to maintain HSC function and prevent propagation of deleterious mutations. Here we investigate the role of the BH3-only Bcl-2 family member Bid in the response of murine hematopoietic cells to long-term replicative stress induced by hydroxyurea (HU). The PI3-like serine/threonine kinase, ATR, initiates the DNA damage response (DDR) to replicative stress. The pro-apoptotic Bcl-2 family member, Bid, facilitates this response to replicative stress in hematopoietic cells, but the in vivo role of this DDR function of Bid has not been defined. Surprisingly, we demonstrate that long-term HU treatment expands wild-type myeloid progenitor cells (MPCs) and HSC-enriched Lin(-)Sca1(+)Kit(+) (LSK) cells to maintain bone marrow function as measured by long-term competitive repopulating ability. Bid-/- MPCs demonstrate increased sensitivity to HU and are depleted. Bid-/- LSK cells demonstrate increased mobilization manifest by increased Bromodeoxyuridine (BrdU) incorporation. Bid-/- MPCs and LSK cells are relatively depleted, however, and bone marrow from Bid-/- mice demonstrates decreased long-term competitive repopulating ability in both primary and secondary transplants. We thus describe a survival function of Bid in hematopoiesis in the setting of chronic replicative stress.

  5. 48 CFR 242.771 - Independent research and development and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Indirect Cost Rates 242.771 Independent research and development and bid and proposal costs. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Independent research and development and bid and proposal costs. 242.771 Section 242.771 Federal Acquisition Regulations System...

  6. 48 CFR 970.3102-05-18 - Independent research and development and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... proposal costs. (c) Independent Research and Development and Bid and Proposal costs are unallowable... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and development and bid and proposal costs. 970.3102-05-18 Section 970.3102-05-18 Federal Acquisition...

  7. 47 CFR 1.2105 - Bidding application and certification procedures; prohibition of certain communications.

    Science.gov (United States)

    2010-10-01

    .... (6) Any applicant that makes or receives a communication of bids or bidding strategies prohibited... immediately, and in no case later than five business days after the communication occurs. An applicant's... procedures; prohibition of certain communications. 1.2105 Section 1.2105 Telecommunication...

  8. The degree of rationality in actual bidding of hydropower at Nord Pool

    DEFF Research Database (Denmark)

    Alnæs, Erik Nicholas; Grøndahl, Roger; Fleten, Stein-Erik;

    2013-01-01

    In deregulated electricity markets, power producers bid to sell tomorrow's generation in day-ahead auctions. We analyse bids submitted by three medium to large sized Norwegian reservoir hydropower producers over four two-week periods in 2011. Being price takers, the producers maximize their profi...

  9. Implementation of the Takeover Bids Directive in the Netherlands : Chapter 12

    NARCIS (Netherlands)

    Cremers, Jan; van Het Kaar, R.H.; Cremers, Jan; Vitols, Sigurt

    2016-01-01

    Chapter dedicated to the Dutch implementation of EU Takeover Bids Directive. The case is particularly interesting because of the strong position of works councils within Dutch companies, including in restructuring situations. Implementation of the Takeover Bids Directive in the Netherlands did not l

  10. 47 CFR 25.401 - Satellite DARS applications subject to competitive bidding.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Satellite DARS applications subject to...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Competitive Bidding Procedures for DARS § 25.401 Satellite DARS applications subject to competitive bidding. Mutually exclusive initial applications for...

  11. Existence and computation of equilibria of first-price auctions with integral valuations and bids

    DEFF Research Database (Denmark)

    Escamocher, Guillaume; Miltersen, Peter Bro; Santillan, Rocio

    2009-01-01

    We consider existence and computation of symmetric Pure Strategy Nash Equilibrium (PSNE) in single-item, sealed-bid, first-price auctions with integral valuations and bids. For the most general case, we show that existence of PSNE is NP-hard. Then, we present algorithmic results for the case of i...

  12. Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid

    DEFF Research Database (Denmark)

    Jalmar, Olivier; Franc¸ois-Moutal, Liberty; García-Sáez, Ana-Jesus

    2013-01-01

    Caspase-8 is involved in death receptor-mediated apoptosis in type II cells, the proapoptotic programme of which is triggered by truncated Bid. Indeed, caspase-8 and Bid are the known intermediates of this signalling pathway. Cardiolipin has been shown to provide an anchor and an essential activa...

  13. Structural basis of RNA recognition and activation by innate immune receptor RIG-I

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Fuguo; Ramanathan, Anand; Miller, Matthew T.; Tang, Guo-Qing; Gale, Jr., Michael; Patel, Smita S.; Marcotrigiano, Joseph (Rutgers); (RWJ-Med); (UW-MED)

    2012-05-29

    Retinoic-acid-inducible gene-I (RIG-I; also known as DDX58) is a cytoplasmic pathogen recognition receptor that recognizes pathogen-associated molecular pattern (PAMP) motifs to differentiate between viral and cellular RNAs. RIG-I is activated by blunt-ended double-stranded (ds)RNA with or without a 5'-triphosphate (ppp), by single-stranded RNA marked by a 5'-ppp and by polyuridine sequences. Upon binding to such PAMP motifs, RIG-I initiates a signalling cascade that induces innate immune defences and inflammatory cytokines to establish an antiviral state. The RIG-I pathway is highly regulated and aberrant signalling leads to apoptosis, altered cell differentiation, inflammation, autoimmune diseases and cancer. The helicase and repressor domains (RD) of RIG-I recognize dsRNA and 5'-ppp RNA to activate the two amino-terminal caspase recruitment domains (CARDs) for signalling. Here, to understand the synergy between the helicase and the RD for RNA binding, and the contribution of ATP hydrolysis to RIG-I activation, we determined the structure of human RIG-I helicase-RD in complex with dsRNA and an ATP analogue. The helicase-RD organizes into a ring around dsRNA, capping one end, while contacting both strands using previously uncharacterized motifs to recognize dsRNA. Small-angle X-ray scattering, limited proteolysis and differential scanning fluorimetry indicate that RIG-I is in an extended and flexible conformation that compacts upon binding RNA. These results provide a detailed view of the role of helicase in dsRNA recognition, the synergy between the RD and the helicase for RNA binding and the organization of full-length RIG-I bound to dsRNA, and provide evidence of a conformational change upon RNA binding. The RIG-I helicase-RD structure is consistent with dsRNA translocation without unwinding and cooperative binding to RNA. The structure yields unprecedented insight into innate immunity and has a broader impact on other areas of biology, including

  14. Optimal Demand Side Bidding with Carbon Emission by Using MRS Strategy

    Directory of Open Access Journals (Sweden)

    Kaustubh Dwivedi

    2014-01-01

    Full Text Available A new moderate-random-search strategy (MRPSO is used for an optimal bidding strategy of a supplier, considering linear bidding curve model with a precise model and emission as constraints, and who delivered electricity to end users in oligopolistic dynamic electricity is studied. Bidding strategy of a supplier is solved by MRPSO, where mean best position (mbest boosts the diversity and the exploration ability of particle. The MRPSO adopts an attractor pd as the main moving direction of particles, which replaces the velocity update procedure in the particle swarm optimization. The effectiveness of the proposed approach is tested with linear bidding model and the results are compared with the solutions obtained using classical PSO. In this paper, a comparative study has been done by a competitive bidding model tested on IEEE 14- and IEEE 39-bus systems and results motivate the suppliers towards opting green technologies.

  15. Bidding process in online auctions and winning strategy: Rate equation approach

    Science.gov (United States)

    Yang, I.; Kahng, B.

    2006-06-01

    Online auctions have expanded rapidly over the last decade and have become a fascinating new type of business or commercial transaction in this digital era. Here we introduce a master equation for the bidding process that takes place in online auctions. We find that the number of distinct bidders who bid k times up to the t th bidding progresses, called the k -frequent bidder, seems to scale as nk(t)˜tk-2.4 . The successfully transmitted bidding rate by the k -frequent bidder is likely to scale as qk(t)˜k-1.4 , independent of t for large t . This theoretical prediction is close to empirical data. These results imply that bidding at the last moment is a rational and effective strategy to win in an eBay auction.

  16. Bidding process in online auctions and winning strategy:rate equation approach

    CERN Document Server

    Yang, I

    2006-01-01

    Online auctions have expanded rapidly over the last decade and have become a fascinating new type of business or commercial transaction in this digital era. Here we introduce a master equation for the bidding process that takes place in online auctions. We find that the number of distinct bidders who bid $k$ times, called the $k$-frequent bidder, up to the $t$-th bidding progresses as $n_k(t)\\sim tk^{-2.4}$. The successfully transmitted bidding rate by the $k$-frequent bidder is obtained as $q_k(t) \\sim k^{-1.4}$, independent of $t$ for large $t$. This theoretical prediction is in agreement with empirical data. These results imply that bidding at the last moment is a rational and effective strategy to win in an eBay auction.

  17. Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

    Science.gov (United States)

    Anguissola, Sergio; Köhler, Barbara; O'Byrne, Robert; Düssmann, Heiko; Cannon, Mary D; Murray, Frank E; Concannon, Caoimhin G; Rehm, Markus; Kögel, Donat; Prehn, Jochen H M

    2009-11-01

    The Bcl-2 homology 3-only protein Bid is an important mediator of death receptor-induced apoptosis. Recent reports and this study suggest that Bid may also mediate genotoxic drug-induced apoptosis of various human cancer cells. Here, we characterized the role of Bid and the mechanism of Bid activation during oxaliplatin-induced apoptosis of HeLa cervical cancer cells. Small hairpin RNA-mediated silencing of Bid protected HeLa cells against both death receptor- and oxaliplatin-induced apoptosis. Expression of a Bid mutant in which caspase-8 cleavage site was mutated (D59A) reactivated oxaliplatin-induced apoptosis in Bid-deficient cells but failed to reactivate death receptor-induced apoptosis, suggesting that caspase-8-mediated Bid cleavage did not contribute to oxaliplatin-induced apoptosis. Overexpression of bcl-2 or treatment with the pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-dl-Asp-fluoromethylketone abolished caspase-2, -8, -9, and -3 activation as well as Bid cleavage in response to oxaliplatin, suggesting that Bid cleavage occurred downstream of mitochondrial permeabilization and was predominantly mediated by caspases. We also detected an early activation of calpains in response to oxaliplatin. Calpain inhibition reduced Bid cleavage, mitochondrial depolarization, and activation of caspase-9, -3, -2, and -8 in response to oxaliplatin. Further experiments, however, suggested that Bid cleavage by calpains was not a prerequisite for oxaliplatin-induced apoptosis: single-cell imaging experiments using a yellow fluorescent protein-Bid-cyan fluorescent protein probe demonstrated translocation of full-length Bid to mitochondria that was insensitive to calpain or caspase inhibition. Moreover, calpain inhibition showed a potent protective effect in Bid-silenced cells. In conclusion, our data suggest that calpains and Bid act in a cooperative, but mutually independent, manner to mediate oxaliplatin-induced apoptosis of HeLa cells.

  18. Hydraulic testing of helium cooled irradiation rigs of the IFMIF High Flux Test Module

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Christine, E-mail: Christine.Klein@kit.edu [Karlsruhe Institute of Technology, INR, Eggenstein-Leopoldshafen (Germany); Arbeiter, Frederik; Jackowski, Thomas; Martin, Thomas; Schlindwein, Georg [Karlsruhe Institute of Technology, INR, Eggenstein-Leopoldshafen (Germany)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Uniform perfusion of the multiple parallel minichannels of the rig model B by helium gas, which is of importance to obtain uniform and predictable temperatures, could be verified by measuring the mean velocity profiles of the rectangular jets are measured using hot-wire anemometry. Black-Right-Pointing-Pointer The pressure drop in the test section with rig model B was measured and delivers data for the validation of computational fluid dynamics (CFD) modeling approach for application in the IFMIF High Flux Test Module. The pressure drop depends significantly on the pressure level; acceleration resulting from the volumetric expansion of helium gas has to be modeled carefully in simulations. Black-Right-Pointing-Pointer Measurements with strain gage show the pressure depending deformation of the compartment container without the rig. The results agree well with simulations and approximation calculations. - Abstract: The hydraulic testing of a single 1:1 irradiation rig inside a mock-up container is part of the validation activities which support the engineering design of the High Flux Test Module. Uniform perfusion of the multiple parallel minichannels of the irradiation rigs by helium gas is of importance to obtain uniform and predictable temperatures. To evaluate the uniform distribution to the different parallel minichannels, the mean velocity profiles of the rectangular jets are measured using hot-wire anemometry. The velocity profiles show a symmetric and constant distribution of the mass flow to the parallel minichannels. The pressure drop in the test section with one of the candidate rig shapes is measured. The pressure drop depends significantly on the entrance pressure level; acceleration resulting from the volumetric expansion of helium gas has to be taken into account in simulations. Measurements with strain gage show the pressure depending deformation of the compartment container without the rig. The results agree

  19. 48 CFR 603.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 603.104-4... contractor bid or proposal information and source selection information. (a) The following classes of persons may be authorized to receive contractor bid or proposal information or source selection information...

  20. 48 CFR 1403.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 1403.104-4... marking of contractor bid or proposal information and source selection information. (a) The following classes of persons may be authorized access to contractor bid or proposal information and source...

  1. 48 CFR 1303.104-4 - Disclosure, protection and marking of contractor bid or proposal information and source selection...

    Science.gov (United States)

    2010-10-01

    ... marking of contractor bid or proposal information and source selection information. 1303.104-4 Section... contractor bid or proposal information and source selection information. Contractor bid or proposal information and source selection information must be protected from unauthorized disclosure in accordance...

  2. 31 CFR 356.12 - What are the different types of bids and do they have specific requirements or restrictions?

    Science.gov (United States)

    2010-07-01

    ... BUREAU OF THE PUBLIC DEBT SALE AND ISSUE OF MARKETABLE BOOK-ENTRY TREASURY BILLS, NOTES, AND BONDS... missing decimals as zero, for example, a bid of 5.32 will be treated as 5.320. The rate bid may be a... bid, expressed with three decimals, for example, 4.170. We will treat any missing decimals as...

  3. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

    Science.gov (United States)

    Saito, Takeshi; Hirai, Reiko; Loo, Yueh-Ming; Owen, David; Johnson, Cynthia L.; Sinha, Sangita C.; Akira, Shizuo; Fujita, Takashi; Gale, Michael

    2007-01-01

    RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of IFN-α/β immune defenses that impact cell permissiveness for hepatitis C virus (HCV). Here we evaluated the processes that control RIG-I signaling. RNA binding studies and analysis of cells lacking RIG-I, or the related MDA5 protein, demonstrated that RIG-I, but not MDA5, efficiently binds to secondary structured HCV RNA to confer induction of IFN-β expression. We also found that LGP2, a helicase related to RIG-I and MDA5 but lacking CARDs and functioning as a negative regulator of host defense, binds HCV RNA. In resting cells, RIG-I is maintained as a monomer in an autoinhibited state, but during virus infection and RNA binding it undergoes a conformation shift that promotes self-association and CARD interactions with the IPS-1 adaptor protein to signal IFN regulatory factor 3- and NF-κB-responsive genes. This reaction is governed by an internal repressor domain (RD) that controls RIG-I multimerization and IPS-1 interaction. Deletion of the RIG-I RD resulted in constitutive signaling to the IFN-β promoter, whereas RD expression alone prevented signaling and increased cellular permissiveness to HCV. We identified an analogous RD within LGP2 that interacts in trans with RIG-I to ablate self-association and signaling. Thus, RIG-I is a cytoplasmic sensor of HCV and is governed by RD interactions that are shared with LGP2 as an on/off switch controlling innate defenses. Modulation of RIG-I/LGP2 interaction dynamics may have therapeutic implications for immune regulation. PMID:17190814

  4. The Design and Manufacturing Report of Non-Instrumented Rig for Dual-cooled Annular Fuel Irradiation Test in HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Bang, Je Geon; Lim, Ik Sung; Kim, Sun Ki; Yang, Yong Sik; Song, Kun Woo; Seo, Chul Gyo; Park, Chan Kook

    2008-09-15

    This project is preparing to irradiation test of the developed double cooled annular fuel pellet in HANARO for pursuit advanced performance in High Performance Fuel Technology Development as a part Nuclear Mid and Long-term R and D Program. On the basis test rod is performed the nuclei property and preliminary fuel performance analysis, test rod and non-instrumented rig designed and manufactured for irradiation test in HANARO OR hole. This non- instrumented rig was confirmed the compatibility of HANARO and the integrity of rig structure, and satisfied the quality assurance requirements. This non- instrumented rig is adopt to the irradiation test for double cooled annular fuel pellet in HANARO.

  5. Learning for Dynamic Bidding in Cognitive Radio Resources

    CERN Document Server

    Fu, Fangwen

    2007-01-01

    In this paper, we model the various wireless users in a cognitive radio network as a collection of selfish, autonomous agents that strategically interact in order to acquire the dynamically available spectrum opportunities. Our main focus is on developing solutions for wireless users to successfully compete with each other for the limited and time-varying spectrum opportunities, given the experienced dynamics in the wireless network. We categorize these dynamics into two types: one is the disturbance due to the environment (e.g. wireless channel conditions, source traffic characteristics, etc.) and the other is the impact caused by competing users. To analyze the interactions among users given the environment disturbance, we propose a general stochastic framework for modeling how the competition among users for spectrum opportunities evolves over time. At each stage of the dynamic resource allocation, a central spectrum moderator auctions the available resources and the users strategically bid for the require...

  6. Work over rig itinerary optimization; Otimizacao do itinerario de sondas de intervencao

    Energy Technology Data Exchange (ETDEWEB)

    Paiva, Ronaldo Oliveira de

    1997-07-01

    The costs of work over and the loss of revenue in wells waiting work over rigs are very high. This work proposes methods to prioritize these wells in order to minimize the total cost. To determine the work over sequence it is necessary to compare the rig expense with the wells losses. For calculating the wells losses, it is necessary to analyze the monetary influence of the well shutdown in the production curves. In this work, this analysis is made by using a numerical reservoir simulator. Simplified calculation procedures are also presented. The priority of the wells is based on the reduction of the total cost, which consists of the rig costs plus the revenue losses due to work over waiting. There are many algorithms able to determine the ideal rig path. Simple and intuitive algorithms are implemented and compared. The Simulated Annealing algorithm is recommended. This algorithm was implemented to optimize work over rig routes in a brazilian production region. Optimization of the work over sequence carried out in that region in 1996 identified a potential economy of 15% in the production losses, equivalent to 4.000m{sup 3}/year of oil (25.000 b bl/year). (author)

  7. Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling

    Directory of Open Access Journals (Sweden)

    Vlasak Reinhard

    2011-02-01

    Full Text Available Abstract The nonstructural proteins 1 (NS1 from influenza A and B viruses are known as the main viral factors antagonising the cellular interferon (IFN response, inter alia by inhibiting the retinoic acid-inducible gene I (RIG-I signalling. The cytosolic pattern-recognition receptor RIG-I senses double-stranded RNA and 5'-triphosphate RNA produced during RNA virus infections. Binding to these ligands activates RIG-I and in turn the IFN signalling. We now report that the influenza C virus NS1 protein also inhibits the RIG-I-mediated IFN signalling. Employing luciferase-reporter assays, we show that expression of NS1-C proteins of virus strains C/JJ/50 and C/JHB/1/66 considerably reduced the IFN-β promoter activity. Mapping of the regions from NS1-C of both strains involved in IFN-β promoter inhibition showed that the N-terminal 49 amino acids are dispensable, while the C-terminus is required for proper modulation of the IFN response. When a mutant RIG-I, which is constitutively active without ligand binding, was employed, NS1-C still inhibited the downstream signalling, indicating that IFN inhibitory properties of NS1-C are not necessarily linked to an RNA binding mechanism.

  8. Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode

    Energy Technology Data Exchange (ETDEWEB)

    Akhrymuk, Ivan; Frolov, Ilya; Frolova, Elena I., E-mail: evfrolova@UAB.edu

    2016-01-15

    Alphaviruses are a family of positive-strand RNA viruses that circulate on all continents between mosquito vectors and vertebrate hosts. Despite a significant public health threat, their biology is not sufficiently investigated, and the mechanisms of alphavirus replication and virus–host interaction are insufficiently understood. In this study, we have applied a variety of experimental systems to further understand the mechanism by which infected cells detect replicating alphaviruses. Our new data strongly suggest that activation of the antiviral response by alphavirus-infected cells is determined by the integrity of viral genes encoding proteins with nuclear functions, and by the presence of two cellular pattern recognition receptors (PRRs), RIG-I and MDA5. No type I IFN response is induced in their absence. The presence of either of these PRRs is sufficient for detecting virus replication. However, type I IFN activation in response to pathogenic alphaviruses depends on the basal levels of RIG-I or MDA5. - Highlights: • Both RIG-I and MDA5 detect alphavirus replication. • Alphavirus-induced transcriptional shutoff affects type I IFN induction. • Sensing of alphavirus replication by RIG-I and MDA5 depends on their concentrations. • High basal level of RIG-I and MDA5 allows IFN induction by pathogenic alphaviruses. • This dependence determines the discrepancy between the in vivo and in vitro data.

  9. Design and Checkout of a High Speed Research Nozzle Evaluation Rig

    Science.gov (United States)

    Castner, Raymond S.; Wolter, John D.

    1997-01-01

    The High Flow Jet Exit Rig (HFJER) was designed to provide simulated mixed flow turbojet engine exhaust for one- seventh scale models of advanced High Speed Research test nozzles. The new rig was designed to be used at NASA Lewis Research Center in the Nozzle Acoustic Test Rig and the 8x6 Supersonic Wind Tunnel. Capabilities were also designed to collect nozzle thrust measurement, aerodynamic measurements, and acoustic measurements when installed at the Nozzle Acoustic Test Rig. Simulated engine exhaust can be supplied from a high pressure air source at 33 pounds of air per second at 530 degrees Rankine and nozzle pressure ratios of 4.0. In addition, a combustion unit was designed from a J-58 aircraft engine burner to provide 20 pounds of air per second at 2000 degrees Rankine, also at nozzle pressure ratios of 4.0. These airflow capacities were designed to test High Speed Research nozzles with exhaust areas from eighteen square inches to twenty-two square inches. Nozzle inlet flow measurement is available through pressure and temperature sensors installed in the rig. Research instrumentation on High Speed Research nozzles is available with a maximum of 200 individual pressure and 100 individual temperature measurements. Checkout testing was performed in May 1997 with a 22 square inch ASME long radius flow nozzle. Checkout test results will be summarized and compared to the stated design goals.

  10. An inexpensive heat-and-pull rig for fiber taper fabrication

    CERN Document Server

    Ward, J; Shortt, B; Morrissey, M; Deasy, K; Chormaic, S N

    2006-01-01

    We describe an inexpensive and reproducible method of fabricating adiabatic tapers with 3-4 micron diameter. The method is based on a heat-and-pull rig, whereby a CO2 laser is continuously scanned across a length of fiber that is being pulled synchronously. Our system relies on a CO2 mirror mounted on an inexpensive geared stepper motor in order to scan the laser beam across the taper region and ensure adiabaticity. We show that this system offers a reliable alternative to more traditional rigs incorporating galvanometer scanners. We have routinely obtained transmission losses between 0.1 and 0.3 dB. The operation of the rig is described in detail and an analysis on the produced tapers is provided. The flexibility of the rig is demonstrated by fabricating prolate dielectric microresonators using the microtapering technique. Such a rig is of interest to a range of fields that require tapered fiber fabrication such as microcavity-taper coupling, atom guiding along a tapered fiber, optical fiber sensing and the ...

  11. Optimal Bidding Strategies for Wind Power Producers in the Day-ahead Electricity Market

    Directory of Open Access Journals (Sweden)

    Xiaolin Liu

    2012-11-01

    Full Text Available Wind Power Producers (WPPs seek to maximize profit and minimize the imbalance costs when bidding into the day-ahead market, but uncertainties in the hourly available wind and forecasting errors make the bidding risky. This paper assumes that hourly wind power output given by the forecast follows a normal distribution, and proposes three different bidding strategies, i.e., the expected profit-maximization strategy (EPS, the chance-constrained programming-based strategy (CPS and the multi-objective bidding strategy (ECPS. Analytical solutions under the three strategies are obtained. Comparisons among the three strategies are conducted on a hypothetical wind farm which follows the Spanish market rules. Results show that bid under the EPS is highly dependent on market clearing price, imbalance prices, and also the mean value and standard deviation of wind forecast, and that bid under the CPS is largely driven by risk parameters and the mean value and standard deviation of the wind forecast. The ECPS combining both EPS and CPS tends to choose a compromise bid. Furthermore, the ECPS can effectively control the tradeoff between expected profit and target profit for WPPs operating in volatile electricity markets.

  12. Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium.

    Science.gov (United States)

    Driak, D; Dvorska, M; Bolehovska, P; Svandova, I; Novotny, J; Halaska, M

    2014-01-01

    The most common malignancies of the female genital tract are endometrial carcinomas, whose are generally proceeded by hyperplasia. The maintenance of tissue homeostasis is to great extent governed by apoptosis, whose defects can lead to the preneoplastic and/or cancerous changes. Endometrial apoptosis involves among others three groups of proteins of the Bcl-2 family. First group contains anti-apoptotic proteins (e. g. Bcl-2, Bcl-xL). The other two groups belong to the pro-apoptotic proteins with three (e. g. Bax, Bak) or one (e. g. Bad, Bid) so-called BH domains. Bad and Bid trigger the oligomerization of Bak and Bax protein, which permeabilize the outer mitochondrial wall. Unlike Bid, Bad cannot directly trigger apoptosis. Instead, Bad lowers the threshold at which apoptosis is induced, by binding anti-apoptotic Bcl-2 proteins. However, their mutual counterbalance or synergism in the human endometrium has not been reported yet.In this study, the levels of Bid and Bad were measured using SDS-PAGE and Western blotting with specific antibodies, with the aim to analyse expression of Bid and Bad proteins in normal (NE), hyperplastic (HE) and cancerous (CE) endometrium. We demonstrated that Bid expression in CE reached only 47% and 50% of this observed in NE and HE. Conversely, Bad expression in HE reached only 40% and 36% of this observed in NE and CE, respectively. We detected no significant changes of Bid expression between HE and NE, and levels of Bad protein were not different between CE and NE.Trend of Bid and Bad protein expression is clearly opposite in HE and CE. We hypothesise that disrupted apoptotic program in CE seems to be reduced further by lowering levels of direct apoptotic trigger protein Bid. We suggest that the adenocarcinoma tissue of human endometrium thus tries to strengthen its apoptotic effort by lowering the apoptotic threshold via higher Bad levels.

  13. The method of rigged spaces in singular perturbation theory of self-adjoint operators

    CERN Document Server

    Koshmanenko, Volodymyr; Koshmanenko, Nataliia

    2016-01-01

    This monograph presents the newly developed method of rigged Hilbert spaces as a modern approach in singular perturbation theory. A key notion of this approach is the Lax-Berezansky triple of Hilbert spaces embedded one into another, which specifies the well-known Gelfand topological triple. All kinds of singular interactions described by potentials supported on small sets (like the Dirac δ-potentials, fractals, singular measures, high degree super-singular expressions) admit a rigorous treatment only in terms of the equipped spaces and their scales. The main idea of the method is to use singular perturbations to change inner products in the starting rigged space, and the construction of the perturbed operator by the Berezansky canonical isomorphism (which connects the positive and negative spaces from a new rigged triplet). The approach combines three powerful tools of functional analysis based on the Birman-Krein-Vishik theory of self-adjoint extensions of symmetric operators, the theory of singular quadra...

  14. Developmental test report, assessment of XT-70E percussion drill rig operation in tank farms

    Energy Technology Data Exchange (ETDEWEB)

    Dougherty, L.F., Westinghouse Hanford

    1996-09-10

    The following report documents the testing of the XT-70E percussion drill rig for use in the 241-SX Tank Farm. The test is necessary to support evaluation of the safety and authorization level of the proposed activity of installing up to three new drywells in the 241- SX Tank Farm. The proposed activity plans to install drywells by percussion drilling 7 inch O.D./6 inch I.D. pipe in close proximity of underground storage tanks and associated equipment. The load transmitted from the drill rig`s percussion hammer through the ground to the tank structure and equipment is not known and therefore testing is required to ensure the activity is safe and authorized.

  15. Prion-like behavior of MAVS in RIG-I signaling

    Institute of Scientific and Technical Information of China (English)

    Eva Marie Y Moresco; Diantha La Vine; Bruce Beutler

    2011-01-01

    Viral infection triggers the innate antiviral response in part through activation of RIG-I,a cytoplasmic sensor of 5'-triphosphorylated and uncapped single- or double-stranded RNA,which are not found among endogenous selfRNA.RIG-I signaling depends on the function of mitochondrial antiviral signaling (MAVS) protein,an adapter that links RIG-I,and the related RNA sensor MDA5,to events leading to transcriptional activation by NF-κB and IRF3.In contrast to the cytoplasmic localization of other innate immune signaling adapters,MAVS is positioned at mitochondrial membranes [ 1 ],and to a lesser extent at peroxisomal membranes [2],by virtue of a C-terminal transmembrane domain.

  16. Non-technical skills: enhancing safety in operating theatres (and drilling rigs).

    Science.gov (United States)

    Flin, Rhona

    2014-03-01

    On April 20th 2010, a large Transocean drilling rig called the Deepwater Horizon was operating in the Gulf of Mexico to drill the Macondo well, for the oil company BP. The job was six weeks behind schedule and $58 million over budget and had not been without difficulty: it was a high pressure well, 2.5 miles below the seabed. At 5.45 am, the Halliburton cementing engineer sent an email to say: 'We have completed the job and it went well'. At 9.43 pm, 16 hours later, there was a release of hydrocarbons into the well bore and the drilling rig experienced a catastrophic blowout as the high pressure oil and gas escaped onto the rig and into the ocean. The resulting explosions and fire killed 11 of the crew of 126, injured many more and created an enormous oil spill across the Gulf.

  17. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

    Science.gov (United States)

    Abdullah, Zeinab; Schlee, Martin; Roth, Susanne; Mraheil, Mobarak Abu; Barchet, Winfried; Böttcher, Jan; Hain, Torsten; Geiger, Sergej; Hayakawa, Yoshihiro; Fritz, Jörg H; Civril, Filiz; Hopfner, Karl-Peter; Kurts, Christian; Ruland, Jürgen; Hartmann, Gunther; Chakraborty, Trinad; Knolle, Percy A

    2012-01-01

    Immunity against infection with Listeria monocytogenes is not achieved from innate immune stimulation by contact with killed but requires viable Listeria gaining access to the cytosol of infected cells. It has remained ill-defined how such immune sensing of live Listeria occurs. Here, we report that efficient cytosolic immune sensing requires access of nucleic acids derived from live Listeria to the cytoplasm of infected cells. We found that Listeria released nucleic acids and that such secreted bacterial RNA/DNA was recognized by the cytosolic sensors RIG-I, MDA5 and STING thereby triggering interferon β production. Secreted Listeria nucleic acids also caused RIG-I-dependent IL-1β-production and inflammasome activation. The signalling molecule CARD9 contributed to IL-1β production in response to secreted nucleic acids. In conclusion, cytosolic recognition of secreted bacterial nucleic acids by RIG-I provides a mechanistic explanation for efficient induction of immunity by live bacteria. PMID:23064150

  18. A Multi-Agent Based Equipment Bidding System on the Web

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper puts forward a new framework of multi-agent based equipment bidding system on the Web(MAEBSW). The purpose of the paper is to make the process of enterprise equipment bidding, especially the decisionprocess of enterprise equipment bidding, more intelligent. The system discussed in this paper is an efficient method forthe enterprises doing business electronically. We also present our opinion of the approaches to defining agents. We em-phasize the importance of agent being able to provide explanation about its behavior for the user or other agents. Based onthis opinion we design a new common architecture of most agents in MAEBSW.

  19. Bidding to the Top: VCG and Equilibria of Position-Based Auctions

    OpenAIRE

    Aggarwal, Gagan; Muthukrishnan, S.; Feldman, Jon

    2006-01-01

    Many popular search engines run an auction to determine the placement of advertisements next to search results. Current auctions at Google and Yahoo! let advertisers specify a single amount as their bid in the auction. This bid is interpreted as the maximum amount the advertiser is willing to pay per click on its ad. When search queries arrive, the bids are used to rank the ads linearly on the search result page. The advertisers pay for each user who clicks on their ad, and the amount charged...

  20. Study of impacts of physical contracts and financial contracts on bidding strategies of GENCOs

    Energy Technology Data Exchange (ETDEWEB)

    Xiaoling Chen [Sichuan Electric Power Company, Chengdu (China); He, Y.; Song, Y.H. [Brunel Univ., Uxbridge (United Kingdom). Inst. of Power Systems; Nakanishi, Yosuke; Nakanishi, Chikashi; Takahashi, Satoru; Sekine, Yoshinori [Fuji Electric Group (Japan)

    2004-11-01

    This paper studies the impacts of physical contracts and financial contracts on the bidding strategies of GENCOs, including Physical Bilateral Contracts, Contracts for Difference (CfDs), Call Options and Put Options under discriminatory pricing mechanism. The integrated bidding decision model is applied, which has three main modules - probabilistic local marginal price simulator, market-oriented unit commitment model and multi-criteria decision system. The numerical results show that the GENCO will choose different bidding strategies if it holds different types of contract. The results also suggest that CfDs have the best performance for risk alleviation. (author)

  1. Multi-Objective Bidding Strategy for Genco Using Non-Dominated Sorting Particle Swarm Optimization

    Science.gov (United States)

    Saksinchai, Apinat; Boonchuay, Chanwit; Ongsakul, Weerakorn

    2010-06-01

    This paper proposes a multi-objective bidding strategy for a generation company (GenCo) in uniform price spot market using non-dominated sorting particle swarm optimization (NSPSO). Instead of using a tradeoff technique, NSPSO is introduced to solve the multi-objective strategic bidding problem considering expected profit maximization and risk (profit variation) minimization. Monte Carlo simulation is employed to simulate rivals' bidding behavior. Test results indicate that the proposed approach can provide the efficient non-dominated solution front effectively. In addition, it can be used as a decision making tool for a GenCo compromising between expected profit and price risk in spot market.

  2. A comparison of pay-as-bid and marginal pricing in electricity markets

    Science.gov (United States)

    Ren, Yongjun

    This thesis investigates the behaviour of electricity markets under marginal and pay-as-bid pricing. Marginal pricing is believed to yield the maximum social welfare and is currently implemented by most electricity markets. However, in view of recent electricity market failures, pay-as-bid has been extensively discussed as a possible alternative to marginal pricing. In this research, marginal and pay-as-bid pricing have been analyzed in electricity markets with both perfect and imperfect competition. The perfect competition case is studied under both exact and uncertain system marginal cost prediction. The comparison of the two pricing methods is conducted through two steps: (i) identify the best offer strategy of the generating companies (gencos); (ii) analyze the market performance under these optimum genco strategies. The analysis results together with numerical simulations show that pay-as-bid and marginal pricing are equivalent in a perfect market with exact system marginal cost prediction. In perfect markets with uncertain demand prediction, the two pricing methods are also equivalent but in an expected value sense. If we compare from the perspective of second order statistics, all market performance measures exhibit much lower values under pay-as-bid than under marginal pricing. The risk of deviating from the mean is therefore much higher under marginal pricing than under pay-as-bid. In an imperfect competition market with exact demand prediction, the research shows that pay-as-bid pricing yields lower consumer payments and lower genco profits. This research provides quantitative evidence that challenges some common claims about pay-as-bid pricing. One is that under pay-as-bid, participants would soon learn how to offer so as to obtain the same or higher profits than what they would have obtained under marginal pricing. This research however shows that, under pay-as-bid, participants can at best earn the same profit or expected profit as under marginal

  3. Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.

    Directory of Open Access Journals (Sweden)

    Marie-Line Goulet

    Full Text Available The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5' triphosphate (5'ppp terminal structure. In the present study, an RNA agonist of RIG-I was synthesized in vitro and shown to stimulate RIG-I-dependent antiviral responses at concentrations in the picomolar range. In human lung epithelial A549 cells, 5'pppRNA specifically stimulated multiple parameters of the innate antiviral response, including IRF3, IRF7 and STAT1 activation, and induction of inflammatory and interferon stimulated genes - hallmarks of a fully functional antiviral response. Evaluation of the magnitude and duration of gene expression by transcriptional profiling identified a robust, sustained and diversified antiviral and inflammatory response characterized by enhanced pathogen recognition and interferon (IFN signaling. Bioinformatics analysis further identified a transcriptional signature uniquely induced by 5'pppRNA, and not by IFNα-2b, that included a constellation of IRF7 and NF-kB target genes capable of mobilizing multiple arms of the innate and adaptive immune response. Treatment of primary PBMCs or lung epithelial A549 cells with 5'pppRNA provided significant protection against a spectrum of RNA and DNA viruses. In C57Bl/6 mice, intravenous administration of 5'pppRNA protected animals from a lethal challenge with H1N1 Influenza, reduced virus titers in mouse lungs and protected animals from virus-induced pneumonia. Strikingly, the RIG-I-specific transcriptional response afforded partial protection from influenza challenge, even in the absence of type I interferon signaling. This systems approach provides transcriptional, biochemical, and in vivo analysis of the antiviral efficacy of 5'pppRNA and highlights the therapeutic potential associated with the use of RIG-I agonists as broad spectrum antiviral agents.

  4. Design and Development of Hydraulic Disc Brake Systems for Well Servicing Rig Drawworks

    Institute of Scientific and Technical Information of China (English)

    Gao xiangqian; Zhou Yongxia

    1996-01-01

    @@ The conventional band brakes have been known to be important but also the most unlnerable part in servicing rig deawworks.. The failures in braking and releasing operations haven't well been avoided. There have evidently existed the problems of difficult operation and inconvenient maintenance in this connection. The use of power-assisted hydraulic cylinders or pneumatic cylinders can not meet the requirements of operations either. Since the late 1980s, we have cooperated with Shengli oilfields and others in the successful design and development of PST25 hydraulic disc brake systems for well servicing rig in a fully closed working state.

  5. China's First 6000 m Electric-Driven Desert Oil Drilling Rig

    Institute of Scientific and Technical Information of China (English)

    CP News

    1996-01-01

    @@ The newly-developed Model ZJ 60DS electric-driven desert oil drilling rig with a drilling capacity of 6000 m is the first of its kind in China. It is a success of the common efforts given by seven scientific research institutes and manufacturer with the Lanzhou Petroleum Chemical Engineering Machinery General Factory as the main contractor. The drilling rig passes the technical appraisement jointly organized by the Ministry of Machinery Industry of the People's Republic of China and China National Petroleum Corporation in Lanzhou on March 30, 1996.

  6. Design and Demonstration of a Test-Rig for Static Performance-Studies of Permanent Magnet Couplings

    DEFF Research Database (Denmark)

    Högberg, Stig; Jensen, Bogi Bech; Bendixen, Flemming Buus

    2013-01-01

    The design and construction of an easy-to-use test-rig for permanent magnet couplings is presented. Static torque of permanent magnet couplings as a function of angular displacement is measured of permanent magnet couplings through an semi-automated test system. The test-rig is capable of measuring...

  7. 30 CFR 285.222 - What does MMS do with my bid?

    Science.gov (United States)

    2010-07-01

    ... to, insufficiency, illegality, anti-competitive behavior, administrative error, and the presence of... Energy Leases Competitive Lease Award Process § 285.222 What does MMS do with my bid? (a) If...

  8. Modeling bidding competitiveness and position performance in multi-attribute construction auctions

    Directory of Open Access Journals (Sweden)

    Pablo Ballesteros-Pérez

    2015-12-01

    This paper details a practical methodology based on simple statistical calculations for modeling the performance of a single bidder or a group of bidders, constituting a useful resource for analyzing one’s own success while benchmarking potential bidding competitors.

  9. 47 CFR 1.2102 - Eligibility of applications for competitive bidding.

    Science.gov (United States)

    2010-10-01

    ... applications filed after July 26, 1993, in the Interactive Video Data Service (see 47 CFR part 95, subpart F... rules that apply to competitive bidding, specific service rules should also be consulted....

  10. 7 CFR 1942.18 - Community facilities-Planning, bidding, contracting, constructing.

    Science.gov (United States)

    2010-01-01

    ... International (SBCCI) Standard Building Code. (ii) The date, signature, and seal of a registered architect or..., financial, legal or other services related to planning, bidding, contracting, and constructing community... architectural and engineering reports must conform with customary professional standards. Preliminary...

  11. The Clustering of Bid/Ask Prices and the Spread in the Foreign Exchange Market

    OpenAIRE

    Riccardo Curcio; Charles Goodhart

    1991-01-01

    Following Lawrence Harris (1989b) study of price clustering in stock prices, we examine the smae phenomenon in the forex market. The pattern of clustering in the final digit of bid/ask prices depends on the desired degree of price resolution. The selection of spreads also involves clustering, but this is driven by a different behavioural pattern, consistent with the pure attraction hypothesis. The combination of the two patterns can explain the differing frequencies of final digits in the bid...

  12. Building and Researching the Bidding Model Based on the Cost of Power Plant

    Institute of Scientific and Technical Information of China (English)

    秦春申; 叶春; 赵景峰

    2004-01-01

    A bidding model of neural network was presented to pursue the largest benefit according to the policy of separating power plants from network and bidding transaction. This model bases on the cost of power plant and its research object is a power plant in the market. The market clearing price (MCP) can be predicted and an optimized load curve can be decided in this model. The model may provide technical support for the power plant.

  13. Study on the Winning Probability for a Bid in Procurement Combinational Auction with Tree Structure

    Institute of Scientific and Technical Information of China (English)

    CHEN Jian; HUANG He

    2004-01-01

    In this paper, the processes to determine winning probability for the correspondingbidder's deterministic bid are presented. The analysis of the winning probability is Crucial for studying the bidding equilibria and designing the mechanism of procurement combinational auctions (CAs), and it also provides the decision making support for bidders who are in commercial synergies surrounding.Finally, an example is used to illustrate the feasibility and detailed processes of calculating winning probability.

  14. Current Practices to Decrease Subcontractor Bid Shopping in the Public Sector

    Science.gov (United States)

    1993-01-01

    rarely done because most contractors refuse to accept such a condition (6s15). Those public agencies adhering to the doctrine of promissory estoppel ...also encourage bid shopping. The doctrine of promissory estoppel dictates that a subcontractor must stand by his bid quote if it is used by the prime...Holman was not awarded the subcontract. (3) It is unfair to bind the subcontractor under promissory estoppel without binding the general contractor. (4

  15. Negotiating a demand side bid: City of San Jose case study

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report emphasizes the transferability of the gathered information to other local municipal governments. The report provides: general background information on demand side bidding; advantages and disadvantages of participation; alternative and ``ideal`` scenarios for bidding; review of potential pitfalls and lessons learned; and a general framework of information based on this particular request for DSB proposals and the City of San Joe`s response experience.

  16. The 2003 proposal for a directive on Takeover Bids - Impact on the regulation in Scandinavia

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2003-01-01

    The article analysis the exspected impact of the proposed directive on takeover bids in Denmark, Norway and Sweden. The article focus on the impact on the duties of managers and of the 'mini breack-through rule'.......The article analysis the exspected impact of the proposed directive on takeover bids in Denmark, Norway and Sweden. The article focus on the impact on the duties of managers and of the 'mini breack-through rule'....

  17. Estimation of block values using a competitive bidding in Brazil: the impact of PETROBRAS

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, Ricardo [Universidade Estadual de Campinas, SP (Brazil). Inst. de Geociencias; Suslick, Saul B. [Universidade Estadual de Campinas, SP (Brazil). Inst. de Geociencias. Centro de Estudo do Petroleo

    2004-07-01

    The concession process for oil and gas exploration through competitive bidding marks a significant step in the opening of Brazil's petroleum sector. So far, since 1999, five licensing rounds for oil and gas have taken place in Brazil, where 189 blocks have been bid. Approximately US$ 720 million have been collected conceding about 198 thousands of km{sup 2} in area, involving more than 43 oil companies. PETROBRAS, alone or in a joint venture, is the operator of 116 blocks acquired in the bidding process until 2003. The company invested US$ 230 million in the five rounds and acquired approximately 80 thousands of km{sup 2}. PETROBRAS participation is very important in this new Brazilian regulatory setting, due to its performance as oil firm for 50 years in the country. This paper attempts to delineate the behavior of the PETROBRAS in the five rounds, comparing its participation with other companies and its role as a boundary market marker in the bidding process. Considering that the bid value is a fraction of the estimated reserve value, another objective of this paper is to reach a set of proxies of unknown values of the blocks through the successful bids. The blocks are divided considering their geological characteristics and the winners' value is estimated for each group. The estimated value of the blocks is calculated through stochastic simulation of these bid fractions using a compound probability distribution. The East Margin Deep Water is the most attractive area, where is concentrated about 90% of Brazilian oil production. These values can be used as auxiliary decision framework for new investments by oil firms as well as for the regulatory agency to evaluate bid performance. (author)

  18. Forecasting Winning Bid Prices in an Online Auction Market:Data Mining Approaches

    Institute of Scientific and Technical Information of China (English)

    KIM Hongil; BAEK Seung

    2004-01-01

    To solve information asymmetry problem on online auction, this study suggests and validates a forecasting model of winning bid prices. Especially, it explores the usability of data mining approaches, such as neural network and Bayesian network in building a forecasting model. This research empirically shows that, in forecasting winning bid prices on online auction, data mining techniques have shown better performance than traditional statistical analysis, such as logistic regression and multivariate regression.

  19. One Way to Eliminate Corruption—Educating People——Brief Introduction on Bid

    Institute of Scientific and Technical Information of China (English)

    QiuShi-feng; YangRu-ping

    2001-01-01

    This article,according to the author's working experience in a hydropower project,briefly introduces some basic knowledge about bidding process and sample contract document.It is aiming at giving a common knowledge to the students who will be involved in work relating to bid after their graduation in the college.It is hoped that this kind of knowledge can help people properly use funds for a project and thus corruption can be minimized.

  20. Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).

    Science.gov (United States)

    Salvadori, Severo; Fiorini, Stella; Trapella, Claudio; Porreca, Frank; Davis, Peg; Sasaki, Yusuke; Ambo, Akihiro; Marczak, Ewa D; Lazarus, Lawrence H; Balboni, Gianfranco

    2008-03-15

    H-Dmt-Tic-NH-CH(2)-Bid (UFP-502) was the first delta-opioid agonist prepared from the Dmt-Tic pharmacophore. It showed interesting pharmacological properties, such as stimulation of mRNA BDNF expression and antidepression. To evaluate the importance of 1H-benzimidazol-2-yl (Bid) in the induction of delta-agonism, it was substituted by similar heterocycles: The substitution of NH(1) by O or S transforms the reference delta-agonist into delta-antagonists. Phenyl ring of benzimidazole is not important for delta-agonism; in fact 1H-imidazole-2-yl retains delta-agonist activity.

  1. New Sealed-Bid Electronic Auction with Fairness, Security and Efficiency

    Institute of Scientific and Technical Information of China (English)

    Chia-Chi Wu; Chin-Chen Chang; Iuon-Chang Lin

    2008-01-01

    Electronic sealed-bid auction schemes usually have a common drawback, the third party (auction host) can conspire with a malicious bidder to leak all bidding prices before the opening stage. It results in the malicious bidder wining the auction with an optimal bidding price. Recently, Liaw et al. proposed an auction protocol for electronic online bidding in which they designed a deposit deduction certification for government procurement. However, it also has above mentioned flaw. Moreover, we further found that there were some extra security drawbacks in their protocol. First, the bidder can forge a bidding receipt to claim that he/she is a valid auction winner. Second, it may suffer from the third party forging attack. Third, their protocol leaked some bidders' private information to the third party, such as the bidder's bank account number and the authorization code. Thus, it cannot protect the bidder's privacy at all. In this paper, we not only point out the drawbacks from the previous scheme but also propose a new electronic auction scheme to overcome the above mentioned drawbacks. Furthermore, the computational complexity can be decreased in our online sealed-bid auction scheme.

  2. Minority business bidding for local government contracts: the complexity of availability.

    Science.gov (United States)

    Bangs, Ralph L; Murrell, Audrey; Constance-Huggins, Monique

    2007-01-01

    While minority-business enterprises (MBEs) have gained some access to local government contracts during the last three decades, these firms continue to receive a small share of local government contract spending relative to the number of available firms. Researchers have suggested two general explanations for the low representation of MBEs in contract awards: (1) lack of qualifications and capacity among MBEs, and (2) public and private discrimination against MBEs in contracting processes. This study on prime contract opportunities in a Northern central city and county with a large minority population finds that low bid rates greatly contribute to the low MBE shares of prime contracts and that bidding is reduced by both local government processes and characteristics of the firms. Some implications of these findings are that local governments need to: (1) monitor MBE shares of prime contract bids by size of contract and use share of bids as one measure of program and organizational effectiveness; (2) identify MBEs that are qualified for prime contracts and encourage and help interested firms to submit competitive bids; and (3) ensure that local government policies and practices do not diminish access to information about prime contract opportunities for qualified and interested minority firms. Another implication is that bidders lists should not be a primary basis for determining MBE availability, since many qualified and interested MBEs do not bid because of perceived barriers in local government.

  3. BIDS apps: Improving ease of use, accessibility, and reproducibility of neuroimaging data analysis methods

    Science.gov (United States)

    Auer, Tibor; Churchill, Nathan W.; Flandin, Guillaume; Guntupalli, J. Swaroop; Raffelt, David; Quirion, Pierre-Olivier; Smith, Robert E.; Strother, Stephen C.; Varoquaux, Gaël

    2017-01-01

    The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms. PMID:28278228

  4. Optimal bidding strategies in oligopoly markets considering bilateral contracts and transmission constraints

    Energy Technology Data Exchange (ETDEWEB)

    A.Badri; Jadid, S. [Department of Electrical Engineering, Iran University of Science and Technology (Iran); Rashidinejad, M. [Shahid Bahonar University, Kerman (Iran); Moghaddam, M.P. [Tarbiat Modarres University, Tehran (Iran)

    2008-06-15

    In electricity industry with transmission constraints and limited number of producers, Generation Companies (GenCos) are facing an oligopoly market rather than a perfect competition one. Under oligopoly market environment, each GenCo may increase its own profit through a favorable bidding strategy. This paper investigates the problem of developing optimal bidding strategies of GenCos, considering bilateral contracts and transmission constraints. The problem is modeled with a bi-level optimization algorithm, where in the first level each GenCo maximizes its payoff and in the second level a system dispatch will be accomplished through an OPF problem in which transmission constraints are taken into account. It is assumed that each GenCo has information about initial bidding strategies of other competitors. Impacts of exercising market power due to transmission constraints as well as irrational biddings of the some generators are studied and the interactions of different bidding strategies on participants' corresponding payoffs are presented. Furthermore, a risk management-based method to obtain GenCos' optimal bilateral contracts is proposed and the impacts of these contracts on GenCos' optimal biddings and obtained payoffs are investigated. At the end, IEEE 30-bus test system is used for the case study in order to demonstrate the simulation results and support the effectiveness of the proposed model. (author)

  5. A vague-set-based fuzzy multi-objective decision making model for bidding purchase

    Institute of Scientific and Technical Information of China (English)

    WANG Zhou-jing; QIAN Edward Y.

    2007-01-01

    A vague-set-based fuzzy multi-objective decision making model is developed for evaluating bidding plans in a bidding purchase process. A group of decision-makers (DMs) first independently assess bidding plans according to their experience and preferences, and these assessments may be expressed as linguistic terms, which are then converted to fuzzy numbers. The resulting decision matrices are then transformed to objective membership grade matrices. The lower bound of satisfaction and upper bound of dissatisfaction are used to determine each bidding plan's supporting, opposing, and neutral objective sets, which together determine the vague value of a bidding plan. Finally, a score function is employed to rank all bidding plans. A new score function based on vague sets is introduced in the model and a novel method is presented for calculating the lower bound of satisfaction and upper bound of dissatisfaction. In a vague-set-based fuzzy multi-objective decision making model, different valuations for upper and lower bounds of satisfaction usually lead to distinct ranking results. Therefore, it is crucial to effectively contain DMs' arbitrariness and subjectivity when these values are determined.

  6. Research on Power Producer’s Bidding Behavior Based on the Best-Response Dynamic Model

    Directory of Open Access Journals (Sweden)

    Jingqi Sun

    2014-01-01

    Full Text Available As China’s electricity market is facing many problems, the research on power producer’s bidding behavior can promote the healthy and sustainable development of China’s electricity market. As a special commodity, the “electricity” possesses complicated production process. The instable market constraint condition, nonsymmetric information, and a lot of random factors make the producer’s bidding process more complex. Best-response dynamic is one of the classic dynamic mechanisms of the evolutionary game theory, which applies well in the repeated game and strategy evolution that happen among a few bounded rational players with a quick learning capability. The best-response dynamic mechanism is employed to study the power producer’s bidding behavior in this paper, the producer’s best-response dynamic model is constructed, and how the producers would engage in bidding is analyzed in detail. Taking two generating units in South China regional electricity market as the example, the producer’s bidding behavior by following the producer’s best-response dynamic model is verified. The relationships between the evolutionarily stable strategy (ESS of power producer’s bidding and the market demand, and ceiling and floor price as well as biding frequency are discussed in detail.

  7. Development and verification of a reciprocating test rig designed for investigation of piston ring tribology

    DEFF Research Database (Denmark)

    Pedersen, Michael Torben; Imran, Tajammal; Klit, Peder

    2009-01-01

    This paper describes the development and verification of a reciprocating test rig, which was designed to study the piston ring tribology. A crank mechanism is used to generate a reciprocating motion for a moving plate, which acts as the liner. A stationary block acting as the ring package is loaded......, which is suitable for the study of piston ring tribology....

  8. A kinematic-freedom analysis of a flexed-knee-stance testing rig.

    Science.gov (United States)

    Zavatsky, A B

    1997-03-01

    The Oxford Rig was designed for biomechanical testing of post-mortem human knee-joint specimens during simulated flexed-knee stance, such as occurs when riding a bicycle, rising from a chair, or climbing stairs. It has been asserted, but never proven, that the movements of the 'ankle' and 'hip' assemblies of the Oxford Rig combine to allow a knee specimen its natural six degrees-of-freedom of movement (6 d.o.f.). This paper investigates this claim mathematically using the general mobility criterion for spatial linkages and the basics of screw theory. It is shown that within the physiological range of knee-joint movement and the physical construction of the Rig, the knee specimen is allowed full spatial freedom (6 d.o.f.). The general approach used in this paper could also be applied to the analysis and, in particular, to the design of other rigs used for biomechanical testing of post-mortem human joint specimens.

  9. A Built for Purpose Micro-Hole Coiled Tubing Rig (MCTR)

    Energy Technology Data Exchange (ETDEWEB)

    Bart Patton

    2007-09-30

    This report will serve as the final report on the work performed from the contract period October 2005 thru April 2007. The project 'A Built for Purpose Microhole Coiled Tubing Rig (MCTR)' purpose was to upgrade an existing state-of-the-art Coiled Tubing Drilling Rig to a Microhole Coiled Tubing Rig (MCTR) capable of meeting the specifications and tasks of the Department of Energy. The individual tasks outlined to meet the Department of Energy's specifications are: (1) Concept and development of lubricator and tool deployment system; (2) Concept and development of process control and data acquisition; (3) Concept and development of safety and efficiency improvements; and (4) Final unit integration and testing. The end result of the MCTR upgrade has produced a unit capable of meeting the following requirements: (1) Capable of handling 1-inch through 2-3/8-inch coiled tubing (Currently dressed for 2-3/8-inch coiled tubing and capable of running up to 3-1/2-inch coiled tubing); (2) Capable of drilling and casing surface, intermediate, production and liner hole intervals; (3) Capable of drilling with coiled tubing and has all controls and installation piping for a top drive; (4) Rig is capable of running 7-5/8-inch range 2 casing; and (5) Capable of drilling 5,000 ft true vertical depth (TVD) and 6,000 ft true measured depth (TMD).

  10. 16 CFR Figure 1 to Part 1512 - Bicycle Front Fork Cantilever Bending Test Rig

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Bicycle Front Fork Cantilever Bending Test Rig 1 Figure 1 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 1 Figure 1 to Part 1512—Bicycle...

  11. Complete Genome Sequence of the Campylobacter ureolyticus Clinical Isolate RIGS 9880

    DEFF Research Database (Denmark)

    Miller, William G; Yee, Emma; On, Stephen L W;

    2015-01-01

    The emerging pathogen Campylobacter ureolyticus has been isolated from human and animal genital infections, human periodontal disease, domestic and food animals, and from cases of human gastroenteritis. We report the whole-genome sequence of the human clinical isolate RIGS 9880, which is the first...

  12. Pattern recognition and signaling mechanisms of RIG-I and MDA5

    Directory of Open Access Journals (Sweden)

    Stephanie eReikine

    2014-07-01

    Full Text Available Most organisms rely on innate immune receptors to recognize conserved molecular structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5, detect viral double-stranded RNA in the cytoplasm. The inflammatory response triggered by these RIG-I-like receptors (RLRs is one of the first and most important lines of defense against infection. RIG-I recognizes short RNA ligands with 5’-triphosphate caps. MDA5 recognizes long kilobase-scale genomic RNA and replication intermediates. Ligand binding induces conformational changes and oligomerization of RLRs that activate the signaling partner MAVS on the mitochondrial and peroxisomal membranes. This signaling process is under tight regulation, dependent on post-translational modifications of RIG-I and MDA5, and on regulatory proteins including unanchored ubiquitin chains and a third RLR, LGP2. Here we review recent advances that have shifted the paradigm of RLR signaling away from the conventional linear signaling cascade. In the emerging RLR signaling model, large multimeric signaling platforms generate a highly cooperative, self-propagating and context-dependent signal, which varies with the subcellular localization of the signaling platform.

  13. An Experience-Based Evaluation Process for ERP Bids

    Directory of Open Access Journals (Sweden)

    Adnan Al Bar

    2014-04-01

    Full Text Available Enterprise Resource Planning (ERP systems integrate information across an entire organization that automate core activities such as finance/accounting , human resources, manufacturing, production and upply chain management... etc. to facilitate an inte grated centralized system and rapid decision making – resulting in cost reduction, greater planning, and increased control. Many organizations are updating their current management information systems with ERP sys tems. This is not a trivial task. They have to identify the organization’s objectives and satisfy a myriad of stakeholders. They have to understand what business processes they have, how they can be improved, and what particular systems would best suit their needs . They have to understand how an ERP system is built; it involves the modification of an existing system with its own set of business rules. Deciding what to ask for and how to select the best option is a very complex operation and there is limited experience with this type of contractingn organizations. In this paper we discuss a particular experience with contracting out an ERP system, provide some lessons learned, and offer suggestions in how the RFP and bid selection processes could have been improved.

  14. DMPD: Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immuneresponse. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17667934 Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate imm...g) (.svg) (.html) (.csml) Show Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune...response. PubmedID 17667934 Title Toll-like receptors, RIG-I-like RNA helicases and the anti

  15. The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I.

    Directory of Open Access Journals (Sweden)

    William G Davis

    Full Text Available Retinoic acid inducible gene-I (RIG-I is a key regulator of antiviral immunity. RIG-I is generally thought to be activated by ssRNA species containing a 5'-triphosphate (PPP group or by unphosphorylated dsRNA up to ~300 bp in length. However, it is not yet clear how changes in the length, nucleotide sequence, secondary structure, and 5' end modification affect the abilities of these ligands to bind and activate RIG-I. To further investigate these parameters in the context of naturally occurring ligands, we examined RNA sequences derived from the 5' and 3' untranslated regions (UTR of the influenza virus NS1 gene segment. As expected, RIG-I-dependent interferon-β (IFN-β induction by sequences from the 5' UTR of the influenza cRNA or its complement (26 nt in length required the presence of a 5'PPP group. In contrast, activation of RIG-I by the 3' UTR cRNA sequence or its complement (172 nt exhibited only a partial 5'PPP-dependence, as capping the 5' end or treatment with CIP showed a modest reduction in RIG-I activation. Furthermore, induction of IFN-β by a smaller, U/A-rich region within the 3' UTR was completely 5'PPP-independent. Our findings demonstrated that RNA sequence, length, and secondary structure all contributed to whether or not the 5'PPP moiety is needed for interferon induction by RIG-I.

  16. Discussion on new Technology of Oil Drilling Rig%石油钻机新技术探讨

    Institute of Scientific and Technical Information of China (English)

    宋云; 刘文兵

    2015-01-01

    分析了石油勘探开发和工程技术的新发展,特别是针对三大钻机技术(水平井钻井技术、欠平衡钻井技术、深井钻井技术),应运而生的新型石油钻井装备。还阐述了与之相关的新型石油钻井装备,如液压钻机、四象限运行的交流变频电驱钻机、模块钻机、快移快装钻机、钻机智能化、钻机顶驱装置等。%Analysis of the new development of petroleum exploration and development and engineering technology, especial⁃ly for the technology of three type rig technology (horizontal well, less balance well ,deep well drilling), model of petroleum drill⁃ing equipment emerge as the times require. Also elaborated the new oil drilling equipment and related, such as the AC frequency conversion rig, hydraulic drilling rig, four quadrant drive rig, modular drilling rig, quickly moving fast drilling rig, drill rig top drive device of intelligent, etc..

  17. Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction.

    Science.gov (United States)

    Fan, Lina; Briese, Thomas; Lipkin, W Ian

    2010-02-01

    The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection that regulates the cellular beta interferon (IFN-beta) response. The nucleoproteins (NP) of arenaviruses are reported to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3). Here, we demonstrate that the Z proteins of four New World (NW) arenaviruses, Guanarito virus (GTOV), Junin virus (JUNV), Machupo virus (MAVC), and Sabia virus (SABV), bind to RIG-I, resulting in downregulation of the IFN-beta response. We show that expression of the four NW arenavirus Z proteins inhibits IFN-beta mRNA induction in A549 cells in response to RNA bearing 5' phosphates (5'pppRNA). NW arenavirus Z proteins interact with RIG-I in coimmunoprecipitation studies and colocalize with RIG-I. Furthermore, expression of Z proteins interferes with the interaction between RIG-I and MAVS. Z expression also impedes the nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) and IRF-3 activation. Our results indicate that NW arenavirus Z proteins, but not Z protein of the Old World (OW) arenavirus lymphocytic choriomeningitis virus (LCMV) or Lassa virus, bind to RIG-I and inhibit downstream activation of the RIG-I signaling pathway, preventing the transcriptional induction of IFN-beta.

  18. Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.

    Science.gov (United States)

    Hu, Ming-Ming; Liao, Chen-Yang; Yang, Qing; Xie, Xue-Qin; Shu, Hong-Bing

    2017-04-03

    Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and RIG-I-mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoylation at K43/K865 and K96/K888, respectively, before and after viral infection. The sumoylation of MDA5 and RIG-I suppresses their K48-linked polyubiquitination and degradation in uninfected or early-infected cells. Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection. At the late phase of viral infection, both MDA5 and RIG-I are desumoylated by SENP2, resulting in their K48-linked polyubiquitination and degradation. These findings suggest that dynamic sumoylation and desumoylation of MDA5 and RIG-I modulate efficient innate immunity to RNA virus and its timely termination.

  19. A Study on the Dynamic Analysis of the Nuclear Fuel Test Rig Using 1-Way Fluid-Structure Coupled Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Tae-Ho; Hong, Jin-Tae; Ahn, Sung-Ho; Joung, Chang-Young; Heo, Sung-Ho; Jang, Seo-Yun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    1-way fluid-structure coupled analysis is used to estimate the dynamic characteristic of the fuel test rig. the motion at the bottom of the test rig is confirmed. The maximum deformation of the test rig is 0.11 mm. The structural integrity of the test rig is performed by using the comparison with the Von-mises stress of the analysis and yield stress of the material. It is evaluated that the motion at the bottom of the test rig is able to cause other structural problem. Using the 2-way fluid-structural coupled analysis, the structural integrity of the test rig will be performed in further paper. The cooling water with specific flow rate was flowed in the nuclear fuel test rig. The structural integrity of the test rig was affected by the vibration. The fluid-induced vibration test had to be performed to obtain the amplitude of the vibration on the structure. Various test systems was developed. Flow-induced vibration and pressure drop experimental tester was developed in Korea Atomic Energy Research Institute. The vibration test with high fluid flow rate was difficult by the tester. To generate the nuclear fuel test environment, coolant flow simulation system was developed. The scaled nuclear fuel test was able to be performed by the simulation system. The mock-up model of the test rig was used in the simulation system. The mock-up model in the simulation system was manufactured with scaled down full model. In this paper, the fluid induced vibration characteristic of the full model in the nuclear fuel test is studied. The hydraulic pressure on the velocity of the fluid was calculated. The static structure analysis was performed by using the pressure. The structural integrity was assessed using the results of the analysis.

  20. Technology of load-sensitivity used in the hydraulic system of an all-hydraulic core rig

    Institute of Scientific and Technical Information of China (English)

    XIN De-zhong; CHEN Song-ling; WANG Qing-feng

    2009-01-01

    The existing hydraulic system always have problems of temperature rise, run-ning stability and anti-interference of the implementation components, reliability of hydrau-lic components, maintenance difficulties, and other issues. With high efficiency, energy saving, reliability, easy operating, stable running, anti-interference ability, and other ad-vantages, the load-sensitive hydraulic system is more suitable for coal mine all-hydraulic core rig. Therefore, for the technical development of the coal mine all-hydraulic core rig, the load-sensitive technology employed by the rig should be of great significance.

  1. Laboratory facility for testing electric-vehicle batteries Test rig for simulating duty cycles with different discharge modes

    Science.gov (United States)

    Hamilton, J. A.; Rand, D. A. J.

    1983-03-01

    A test rig has been designed and constructed to examine the performance of batteries under laboratory conditions that simulate the power characteristics of electric vehicles. Each station in the rig subjects a battery to continuous charge/discharge cycles, with an equalising charge every eighth cycle. The battery discharge follows the current-verse-time profile of a given vehicle operating under a driving schedule normal to road service. The test rig allows both smooth- and pulsed-current discharge to be investigated. Data collection is accomplished either with multi-pen recorders or with a computer-based information logger.

  2. Molecular factors in cell (and tumor) response to photodynamic therapy: the role of Bid

    Science.gov (United States)

    Chiu, Song-mao; Xue, Liang-yan; Lam, Minh; Rodriguez, Myriam E.; Zhang, Ping; Kenney, Malcolm E.; Nieminen, Anna-Liisa; Oleinick, Nancy L.

    2010-02-01

    The phthalocyanine photosensitizer Pc 4 binds preferentially to mitochondrial and endoplasmic reticulum membranes. Upon photoirradiation of Pc 4-loaded cells, membrane components, including Bcl-2, are photodamaged and apoptosis is triggered. We recently prepared analogues of Pc 4 containing two axial ligands, one identical to the single ligand in Pc 4, and the other containing one or two hydroxyl groups on a dimethylsiloxy alkyl chain. Pc 181 is representative of this group of photosensitizers. In MCF-7 human breast cancer cells, the new analogues preferentially localized in lysosomes and were highly efficient in inducing apoptosis and overall cell death. The Bcl-2 family member Bid is required for signaling to mitochondria for apoptosis in response to primary lysosomal photodamage. To further evaluate the role of Bid, we compared the effects of PDT with Pc 4 or Pc 181 in wild-type murine embryonic fibroblasts and those knocked out for Bid. We find that the two cell lines are equally sensitive to killing by Pc 4-PDT, but the Bid-/- cells are significantly more resistant to killing and apoptosis induction by Pc 181-PDT than are the Bid+/+ cells. The data show that low levels of lysosomal photodamage are not alone lethal and that a specific defect in a factor required for apoptosis can severely compromise cell response to PDT.

  3. Quantifying fluctuations in market liquidity: analysis of the bid-ask spread.

    Science.gov (United States)

    Plerou, Vasiliki; Gopikrishnan, Parameswaran; Stanley, H Eugene

    2005-04-01

    Quantifying the statistical features of the bid-ask spread offers the possibility of understanding some aspects of market liquidity. Using quote data for the 116 most frequently traded stocks on the New York Stock Exchange over the two-year period 1994-1995, we analyze the fluctuations of the average bid-ask spread S over a time interval deltat. We find that S is characterized by a distribution that decays as a power law P[S>x] approximately x(-zeta(S) ), with an exponent zeta(S) approximately = 3 for all 116 stocks analyzed. Our analysis of the autocorrelation function of S shows long-range power-law correlations, (S(t)S(t + tau)) approximately tau(-mu(s)), similar to those previously found for the volatility. We next examine the relationship between the bid-ask spread and the volume Q, and find that S approximately ln Q; we find that a similar logarithmic relationship holds between the transaction-level bid-ask spread and the trade size. We then study the relationship between S and other indicators of market liquidity such as the frequency of trades N and the frequency of quote updates U, and find S approximately ln N and S approximately ln U. Lastly, we show that the bid-ask spread and the volatility are also related logarithmically.

  4. Bidding Strategy for Aggregators of Electric Vehicles in Day-Ahead Electricity Markets

    Directory of Open Access Journals (Sweden)

    Yunpeng Guo

    2017-01-01

    Full Text Available To make full use of the flexible charging and discharging capabilities of the growing number of electric vehicles (EVs, a bidding strategy for EV aggregators to participate in a day-ahead electricity energy market is proposed in this work. The proposed bidding strategy is able to reduce the operating cost of the EV aggregators and to handle the uncertainties of day-ahead market prices properly at the same time. Agreements between the EV owners and the aggregators are discussed, and a hierarchical market structure is proposed. While assuming the aggregators as economic rational entities, the bidding strategy is established based on the market prices, extra battery charging/discharging costs and the expected profits. The bidding clearing system will display the current/temporal market clearance results of the day-ahead market before the final clearance, and hence the market participants can revise their bids and mitigate the risks, to some extent, of forecasted market price forecast errors. Numerical results with a modified IEEE 30-bus system have demonstrated the feasibility and effectiveness of the proposed strategy.

  5. A Bidding Methodology by Nash Equilibrium for Finite Generators Participating in Imperfect Electricity Markets

    Science.gov (United States)

    Satyaramesh, P. V.

    2014-01-01

    This paper presents an application of finite n-person non-cooperative game theory for analyzing bidding strategies of generators in a deregulated energy marketplace with Pool Bilateral contracts so as to maximize their net profits. A new methodology to build bidding methodology for generators participating in oligopoly electricity market has been proposed in this paper. It is assumed that each generator bids a supply function. This methodology finds out the coefficients in the supply function of generators in order to maximize benefits in an environment of competing rival bidders. A natural choice for developing strategies is Nash Equilibrium (NE) model incorporating mixed strategies, for solving the bidding problem of electrical market. Associated optimal profits are evaluated for a combination of set of pure strategies of bidding of generators, and payoff matrix has been constructed. The optimal payoff is calculated by using NE. An attempt has also been made to minimize the gap between the optimal payoff and the payoff obtained by a possible mixed strategies combination. The algorithm is coded in MATLAB. A numerical example is used to illustrate the essential features of the approach and the results are proved to be the optimal values.

  6. Facilitators and Inhibitors of Bidding and Hosting Mega Sporting Events in Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Koosha

    2013-01-01

    Full Text Available Legacies of hosting mega sporting events have been attempting idea for both the developed and the developing nations to participate in "bidding" competitions. Through mega sporting events bid process, despite all defined essentials infrastructures, the viewpoint of local organizing committee play a significant role to propose a winning bid and delivery of successful games. This research aims to identify the facilitators and inhibitors of bidding and hosting mega sporting events in Iran from the viewpoints of the Iranian distinguished professors in the sport management and the sport executive managers. Researcher questionnaire and Semi-structure interviews were conducted to gain in depth data. The results indicated that Iran currently has limitations to have winning bid and successful host mega sporting events; even though, it possesses the potential to do so. Public interest and support for hosting the sport events, good security condition against terrorism and tourist attractions are known as the strong points and he challenges and inhibitors which Iran is faced with includes: the qualitative and quantitative weakness in the transportation infrastructures and sport venues, west countries economic boycott, unstable government support and the lack of long-run planning for the events.

  7. A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Oshiumi

    Full Text Available The innate immune system is essential for controlling viral infections, but several viruses have evolved strategies to escape innate immunity. RIG-I is a cytoplasmic viral RNA sensor that triggers the signal to induce type I interferon production in response to viral infection. RIG-I activation is regulated by the K63-linked polyubiquitin chain mediated by Riplet and TRIM25 ubiquitin ligases. TRIM25 is required for RIG-I oligomerization and interaction with the IPS-1 adaptor molecule. A knockout study revealed that Riplet was essential for RIG-I activation. However the molecular mechanism underlying RIG-I activation by Riplet remains unclear, and the functional differences between Riplet and TRIM25 are also unknown. A genetic study and a pull-down assay indicated that Riplet was dispensable for RIG-I RNA binding activity but required for TRIM25 to activate RIG-I. Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase. Our data indicate that Riplet is a prerequisite for TRIM25 to activate RIG-I signaling. We investigated the biological importance of this mechanism in human cells and found that hepatitis C virus (HCV abrogated this mechanism. Interestingly, HCV NS3-4A proteases targeted the Riplet protein and abrogated endogenous RIG-I polyubiquitination and association with TRIM25 and TBK1, emphasizing the biological importance of this mechanism in human antiviral innate immunity. In conclusion, our results establish that Riplet-mediated K63-linked polyubiquitination released RIG-I RD autorepression, which allowed the access of positive factors to the RIG-I protein.

  8. Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.

    Science.gov (United States)

    Akhrymuk, Ivan; Frolov, Ilya; Frolova, Elena I

    2016-01-01

    Alphaviruses are a family of positive-strand RNA viruses that circulate on all continents between mosquito vectors and vertebrate hosts. Despite a significant public health threat, their biology is not sufficiently investigated, and the mechanisms of alphavirus replication and virus-host interaction are insufficiently understood. In this study, we have applied a variety of experimental systems to further understand the mechanism by which infected cells detect replicating alphaviruses. Our new data strongly suggest that activation of the antiviral response by alphavirus-infected cells is determined by the integrity of viral genes encoding proteins with nuclear functions, and by the presence of two cellular pattern recognition receptors (PRRs), RIG-I and MDA5. No type I IFN response is induced in their absence. The presence of either of these PRRs is sufficient for detecting virus replication. However, type I IFN activation in response to pathogenic alphaviruses depends on the basal levels of RIG-I or MDA5.

  9. A REAL TIME DECISION SUPPORT SYSTEM FOR THE ADJUSTMENT OF SAILBOAT RIGGING

    Directory of Open Access Journals (Sweden)

    Inmaculada Ortigosa

    2016-01-01

    Full Text Available The operational complexity and performance requirements of modern racing yachts demand the use of advanced applications, such as a decision support system (DSS able to assist crew members during navigation. In this article, the authors describe a near-time computational solver as the main piece of a DSS which analyses and monitors the behaviour of sails and rigging. The solver is made up of two different interconnected tools: an iterative Fluid-Structure Interaction algorithm and an advanced Wireless Sensor Network to monitor rigging. The real-time DSS quantifies crew manoeuvres in physical terms, which are reproduced by a simulation program. It can be used in the design phase of sailing yachts and as an aid for real-time boat performance optimisation and accident prevention. This novel DSS is a useful tool for navigation, especially in races.

  10. A Comparison Study of Magnetic Bearing Controllers for a Fully Suspended Dynamic Spin Rig

    Science.gov (United States)

    Choi, Benjamin; Johnson, Dexter; Morrison, Carlos; Mehmed, Oral; Huff, Dennis (Technical Monitor)

    2002-01-01

    NASA Glenn Research Center (GRC) has developed a fully suspended magnetic bearing system for the Dynamic Spin Rig (DSR) that is used to perform vibration tests of turbomachinery blades and components under spinning conditions in a vacuum. Two heteropolar radial magnetic bearings and a thrust bearing and the associated control system were integrated into the DSR to provide noncontact magnetic suspension and mechanical excitation of the 35 lb vertical rotor with blades to induce turbomachinery blade vibration. A simple proportional-integral-derivative (PID) controller with a special feature for multidirectional radial excitation worked very well to both support and shake the shaft with blades. However, more advanced controllers were developed and successfully tested to determine the optimal controller in terms of sensor and processing noise reduction, smaller rotor orbits, and energy savings for the system. The test results of a variety of controllers we demonstrated up to the rig's maximum allowable speed of 10,000 rpm are shown.

  11. Optimal Controller Tested for a Magnetically Suspended Five-Axis Dynamic Spin Rig

    Science.gov (United States)

    Choi, Benjamin B.

    2003-01-01

    NASA Glenn Research Center's Structural Mechanics and Dynamics Branch has developed a fully suspended magnetic bearing system for their Dynamic Spin Rig, which performs vibration tests of turbomachinery blades and components under spinning conditions in a vacuum. Two heteropolar radial magnetic bearings and a thrust magnetic bearing and the associated control system were integrated into the Dynamic Spin Rig to provide magnetic excitation as well as noncontact magnetic suspension of the 35-lb vertical rotor with blades to induce turbomachinery blade vibration (ref. 1). The new system can provide longer run times at higher speeds and larger vibration amplitudes for rotating blades. Also, it was proven that bearing mechanical life was substantially extended and flexibility was increased in the excitation orientation (direction and phasing).

  12. Threshold Assessment of Gear Diagnostic Tools on Flight and Test Rig Data

    Science.gov (United States)

    Dempsey, Paula J.; Mosher, Marianne; Huff, Edward M.

    2003-01-01

    A method for defining thresholds for vibration-based algorithms that provides the minimum number of false alarms while maintaining sensitivity to gear damage was developed. This analysis focused on two vibration based gear damage detection algorithms, FM4 and MSA. This method was developed using vibration data collected during surface fatigue tests performed in a spur gearbox rig. The thresholds were defined based on damage progression during tests with damage. The thresholds false alarm rates were then evaluated on spur gear tests without damage. Next, the same thresholds were applied to flight data from an OH-58 helicopter transmission. Results showed that thresholds defined in test rigs can be used to define thresholds in flight to correctly classify the transmission operation as normal.

  13. Mechanical Design of a Performance Test Rig for the Turbine Air-Flow Task (TAFT)

    Science.gov (United States)

    Forbes, John C.; Xenofos, George D.; Farrow, John L.; Tyler, Tom; Williams, Robert; Sargent, Scott; Moharos, Jozsef

    2004-01-01

    To support development of the Boeing-Rocketdyne RS84 rocket engine, a full-flow, reaction turbine geometry was integrated into the NASA-MSFC turbine air-flow test facility. A mechanical design was generated which minimized the amount of new hardware while incorporating all test and instrumentation requirements. This paper provides details of the mechanical design for this Turbine Air-Flow Task (TAFT) test rig. The mechanical design process utilized for this task included the following basic stages: Conceptual Design. Preliminary Design. Detailed Design. Baseline of Design (including Configuration Control and Drawing Revision). Fabrication. Assembly. During the design process, many lessons were learned that should benefit future test rig design projects. Of primary importance are well-defined requirements early in the design process, a thorough detailed design package, and effective communication with both the customer and the fabrication contractors.

  14. Design and development of a high-speed bearing test rig

    Science.gov (United States)

    Cockburn, J. A.

    1995-01-01

    The development of a high-speed test rig, to be used for compiling an experimental data base of bearing signatures for bearings with known faults, is described. This bearing test rig can be adapted to test oil-film bearings as well as rolling element bearings. This is achieved by mounting the test bearing in one of two special test housings, either of which can be mounted onto a common test shaft which can be driven up to 30,000 rpm. The test bearing housing for rolling element bearings can accommodate proximity displacement transducers, accelerometers, thermocouples, and acoustic emission sensors. The test bearing housing for the fluid-film bearings can accommodate the same instrumentation as well as Bourdon tube-type transducers for measuring oil film pressures around the bearing circumference.

  15. FUNCTIONAL REQUIREMENTS FOR STABILITY OF JACK UP DRILLING RIGS ON WORKING POSITION

    Directory of Open Access Journals (Sweden)

    Damir Zadravec

    2008-12-01

    Full Text Available Jack up drilling platforms are offshore drilling units composed by drilling rig situated on naval structure without self propelling device. Jack up drilling rigs are units used for drilling and completion of deep well bores in offshore oil and gas exploration industry or field development. By reaching the theoretical center of gravity and equilibrium while towing and balance of acting forces on the unit while operations on location ensures the stability and safe mode of operations of entire unit. Penetration of legs spud cans in sea bad produced by weight of unit and acting of preload force, depending on geotechnical characteristics, type and bearing capacity of sea bad, and taking in consideration working environmental forces which acts on unit (wind, waves, sea current, ice, snow ensures proper foundation, environmental forces balancing and safe mode of operations (the paper is published in Croatian.

  16. Development of a test rig for a helium twin-screw compressor

    Science.gov (United States)

    Wang, B. M.; Hu, Z. J.; Zhang, P.; Li, Q.

    2014-01-01

    A large helium cryogenic system is being developed for use in great science projects, such as the International Thermonuclear Experimental Reactor (ITER), Large Helical Device (LHD), and the Experimental Advanced Superconducting Tokamak (EAST). In this cryogenic system, a twin-screw compressor is a key component. Therefore, it is necessary to obtain the compressor performance. To obtain the performance characteristics, a test rig for the compressor has been built. All the important performance parameters, including adiabatic efficiency, volumetric efficiency, oil injection characteristic, and noise characteristic can be acquired with the rig when sensors are installed in the test system. With the test performance, the helium twin-screw compressor can be evaluated. Using these results, the design of the compressor can be improved.

  17. The Hydraulic Test Procedure for Non-instrumented Irradiation Test Rig of Annular Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Lee, Kang Hee; Shin, Chang Hwan; Park, Chan Kook

    2008-08-15

    This report presents the procedure of pressure drop test, vibration test and endurance test for the non-instrumented rig using the irradiation test in HANARO of advanced PWR annular fuel which were designed and fabricated by KAERI. From the out-pile thermal hydraulic tests, confirm the flow rate at the 200 kPa pressure drop and measure the RMS displacement at this time. And the endurance test is confirmed the wear and the integrity of the non-instrumented rig at the 110% design flow rate. This out-pile test perform the Flow-Induced Vibration and Pressure Drop Experimental Tester(FIVPET) facility. The instruments in FIVPET facility was calibrated in KAERI and the pump and the thermocouple were certified by manufacturer.

  18. Mixed mode properties of CNT reinforced composites using Arcan test rig

    Institute of Scientific and Technical Information of China (English)

    Jacob MUTHU

    2015-01-01

    Composite materials reinforced with carbon nanotubes were mechanical tested using Arcan test rig under Mode-I, Mode-II and mixed mode loading conditions to obtain their fracture properties. The butterfly composite specimens were fabricated with 0.02, 0.05 and 0. I wt % CNTs. The polyester/CNT composite was fabricated using VRTM (Vacuum Resin Transfer Molding) where the CNTs were first functionalised to reach an optimum properties. Arcan test rig was designed and fabricated to work with the Shimadzu testing machine. The results show that the functionalised CNTs have improved the fracture behavior by acting as bridge between the cracked face. In addition, the fracture properties were not improved for the higher weight fraction of 0.1 wt% CNTs.

  19. Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity

    Institute of Scientific and Technical Information of China (English)

    John; S.Errett; Michael; Gale; Jr.

    2015-01-01

    Innate immunity is critical for the control of virus infection and operates to restrict viral susceptibility and direct antiviral immunity for protection from acute or chronic viral-associated diseases including cancer. RIG-I like receptors(RLRs) are cytosolic RNA helicases that function as pathogen recognition receptors to detect RNA pathogen associated molecular patterns(PAMPs) of virus infection. The RLRs include RIG-I, MDA5, and LGP2. They function to recognize and bind to PAMP motifs within viral RNA in a process that directs the RLR to trigger downstream signaling cascades that induce innate immunity that controls viral replication and spread. Products of RLR signaling also serve to modulate the adaptive immune response to infection. Recent studies have additionally connected RLRs to signaling cascades that impart inflammatory and apoptotic responses to virus infection. Viral evasion of RLR signaling supports viral outgrowth and pathogenesis, including the onset of viral-associated cancer.

  20. The predictive analysis of wear work-rates in wear test rigs

    Energy Technology Data Exchange (ETDEWEB)

    Phalippou, C.; Delaune, X.

    1996-12-31

    Impact and sliding wear in components is classically studied, as far as the wear laws are concerned, in specific wear test rigs that simulate the vibratory motion induced by the flow. In this paper, an experimental and numerical study on the impact forces and wear work-rates of a typical AECL rig is presented. The mode shapes and frequencies are measured and compared with finite element computations. Impact and sliding motions between the wear specimens are calculated and compared to the experimental results. Impact forces, mean values of wear work-rates as well as the specimen relative motions are found to be close to the experimental data. (authors). 14 refs., 9 figs., 5 tabs.

  1. Multibody dynamics modelling and system identification of a quarter-car test rig with McPherson strut suspension

    Science.gov (United States)

    Sandu, Corina; Andersen, Erik R.; Southward, Steve

    2011-02-01

    In this paper, we develop a multibody dynamics model of a quarter-car test-rig equipped with a McPherson strut suspension and we apply a system identification technique on it. Constrained equations of motion in the Lagrange multiplier form are derived and employed to characterise the dynamic behaviour of the test rig modelled once as a linear system and once as a non-linear system. The system of differential algebraic equations is integrated using a Hilber-Hughes-Taylor integrator. The responses of both models (linear and non-linear) to a given displacement input are obtained and compared with the experimental response recorded using the physical quarter-car test rig equipped with a McPherson strut suspension. The system identification is performed for control purposes. The results, as well as the performance and area of applicability of the test rig models derived, are discussed.

  2. 78 FR 70326 - Rigging Equipment for Material Handling; Extension of the Office of Management and Budget's (OMB...

    Science.gov (United States)

    2013-11-25

    ... require affixing identification tags or markings on rigging equipment, developing and maintaining... read or download through the Web site. All submissions, including copyrighted material, are available... durable identification tags stating size, grade, rated capacity and sling ] manufacturer. Paragraph...

  3. The Hydraulic Test Report for Non-instrumented Irradiation Test Rig of DUO-Cooled Annular Pellet

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Lee, Kang Hee; Shin, Chang Hwan; Yang, Yong Sik; Kim, Sun Ki; Bang, Je Geon; Song, Kun Woo

    2007-08-15

    This report presents the results of pressure drop test and vibration test for non-instrumented rig of Advanced PWR DUO-Fuel Annular Pellet which were designed and fabricated by KAERI. From the pressure drop test results, it is noted that the flow velocity across the non-instrumented rig of Advanced PWR DUO-Fuel Annular Pellet corresponding to the pressure drop of 200 kPa is measured to be about 8.30 kg/sec. Vibration frequency results for the non-instrumented rig at the pump spin frequency ranges from 19.0 to 32.0 Hz, RMS(Root Mean Square) displacement for the non-instrumented rig of Advanced PWR DUO-Fuel Annular Pellet is less than 7.25 m, and the maximum displacement is less than 31.27 {mu}m. This test was performed at the FIVPET facility.

  4. Design of multi-module experiment-rig of vessel electrical propulsion prime mover

    Institute of Scientific and Technical Information of China (English)

    XIE Chun-ling; WANG Yuan-hui

    2005-01-01

    Combined power plant is widely used in large or medium surface vessel for its predominant performance. It is important to research on using combined power plant as electrical propulsion prime mover for developing the electric propulsion warship.This paper, designs a multi-module experiment-rig and introduces its composition, working principle and disposition scheme,and carried out the dynamic characteristic experiment of the GTD350 gas turbine.

  5. Design of Seismic Test Rig for Control Rod Drive Mechanism of Jordan Research and Training Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Jongoh; Kim, Gyeongho; Yoo, Yeonsik; Cho, Yeonggarp; Kim, Jong In [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The reactor assembly is submerged in a reactor pool filled with water and its reactivity is controlled by locations of four control absorber rods(CARs) inside the reactor assembly. Each CAR is driven by a stepping motor installed at the top of the reactor pool and they are connected to each other by a tie rod and an electromagnet. The CARs scram the reactor by de-energizing the electromagnet in the event of a safe shutdown earthquake(SSE). Therefore, the safety function of the control rod drive mechanism(CRDM) which consists of a drive assembly, tie rod and CARs is to drop the CAR into the core within an appropriate time in case of the SSE. As well known, the operability for complex equipment such as the CRDM during an earthquake is very hard to be demonstrated by analysis and should be verified through tests. One of them simulates the reactor assembly and the guide tube of the CAR, and the other one does the pool wall where the drive assembly is installed. In this paper, design of the latter test rig and how the test is performed are presented. Initial design of the seismic test rig and excitation table had its first natural frequency at 16.3Hz and could not represent the environment where the CRDM was installed. Therefore, experimental modal analyses were performed and an FE model for the test rig and table was obtained and tuned based on the experimental results. Using the FE model, the design of the test rig and table was modified in order to have higher natural frequency than the cutoff frequency. The goal was achieved by changing its center of gravity and the stiffness of its sliding bearings.

  6. Fully Suspended, Five-Axis, Three-Magnetic-Bearing Dynamic Spin Rig With Forced Excitation

    Science.gov (United States)

    Morrison, Carlos R.; Provenza, Andrew; Kurkov, Anatole; Montague, Gerald; Duffy, Kirsten; Mehmed, Oral; Johnson, Dexter; Jansen, Ralph

    2004-01-01

    The Five-Axis, Three-Magnetic-Bearing Dynamic Spin Rig, a significant advancement in the Dynamic Spin Rig (DSR), is used to perform vibration tests of turbomachinery blades and components under rotating and nonrotating conditions in a vacuum. The rig has as its critical components three magnetic bearings: two heteropolar radial active magnetic bearings and a magnetic thrust bearing. The bearing configuration allows full vertical rotor magnetic suspension along with a feed-forward control feature, which will enable the excitation of various natural blade modes in bladed disk test articles. The theoretical, mechanical, electrical, and electronic aspects of the rig are discussed. Also presented are the forced-excitation results of a fully levitated, rotating and nonrotating, unbladed rotor and a fully levitated, rotating and nonrotating, bladed rotor in which a pair of blades was arranged 180 degrees apart from each other. These tests include the bounce mode excitation of the rotor in which the rotor was excited at the blade natural frequency of 144 Hz. The rotor natural mode frequency of 355 Hz was discerned from the plot of acceleration versus frequency. For nonrotating blades, a blade-tip excitation amplitude of approximately 100 g/A was achieved at the first-bending critical (approximately 144 Hz) and at the first-torsional and second-bending blade modes. A blade-tip displacement of 70 mils was achieved at the first-bending critical by exciting the blades at a forced-excitation phase angle of 908 relative to the vertical plane containing the blades while simultaneously rotating the shaft at 3000 rpm.

  7. Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.

    Directory of Open Access Journals (Sweden)

    Qian Feng

    Full Text Available Upon viral infections, pattern recognition receptors (PRRs recognize pathogen-associated molecular patterns (PAMPs and stimulate an antiviral state associated with the production of type I interferons (IFNs and inflammatory markers. Type I IFNs play crucial roles in innate antiviral responses by inducing expression of interferon-stimulated genes and by activating components of the adaptive immune system. Although pegylated IFNs have been used to treat hepatitis B and C virus infections for decades, they exert substantial side effects that limit their use. Current efforts are directed toward the use of PRR agonists as an alternative approach to elicit host antiviral responses in a manner similar to that achieved in a natural infection. RIG-I is a cytosolic PRR that recognizes 5' triphosphate (5'ppp-containing RNA ligands. Due to its ubiquitous expression profile, induction of the RIG-I pathway provides a promising platform for the development of novel antiviral agents and vaccine adjuvants. In this study, we investigated whether structured RNA elements in the genome of coxsackievirus B3 (CVB3, a picornavirus that is recognized by MDA5 during infection, could activate RIG-I when supplied with 5'ppp. We show here that a 5'ppp-containing cloverleaf (CL RNA structure is a potent RIG-I inducer that elicits an extensive antiviral response that includes induction of classical interferon-stimulated genes, as well as type III IFNs and proinflammatory cytokines and chemokines. In addition, we show that prophylactic treatment with CVB3 CL provides protection against various viral infections including dengue virus, vesicular stomatitis virus and enterovirus 71, demonstrating the antiviral efficacy of this RNA ligand.

  8. IFNγ inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I.

    Directory of Open Access Journals (Sweden)

    Stephanie P Jehl

    Full Text Available The activation of host cells by interferon gamma (IFNγ is essential for inhibiting the intracellular replication of most microbial pathogens. Although significant advances have been made in identifying IFNγ-dependent host factors that suppress intracellular bacteria, little is known about how IFNγ enables cells to recognize, or restrict, the growth of pathogens that replicate in the host cytoplasm. The replication of the cytosolic bacterial pathogen Shigella flexneri is significantly inhibited in IFNγ-stimulated cells, however the specific mechanisms that mediate this inhibition have remained elusive. We found that S. flexneri efficiently invades IFNγ-activated mouse embryonic fibroblasts (MEFs and escapes from the vacuole, suggesting that IFNγ acts by blocking S. flexneri replication in the cytosol. This restriction on cytosolic growth was dependent on interferon regulatory factor 1 (IRF1, an IFNγ-inducible transcription factor capable of inducing IFNγ-mediated cell-autonomous immunity. To identify host factors that restrict S. flexneri growth, we used whole genome microarrays to identify mammalian genes whose expression in S. flexneri-infected cells is controlled by IFNγ and IRF1. Among the genes we identified was the pattern recognition receptor (PRR retanoic acid-inducible gene I (RIG-I, a cytoplasmic sensor of foreign RNA that had not been previously known to play a role in S. flexneri infection. We found that RIG-I and its downstream signaling adaptor mitochondrial antiviral signaling protein (MAVS--but not cytosolic Nod-like receptors (NLRs--are critically important for IFNγ-mediated S. flexneri growth restriction. The recently described RNA polymerase III pathway, which transcribes foreign cytosolic DNA into the RIG-I ligand 5'-triphosphate RNA, appeared to be involved in this restriction. The finding that RIG-I responds to S. flexneri infection during the IFNγ response extends the range of PRRs that are capable of recognizing

  9. Field Trials of the Prototype Pounder Rig, Uganda, 20th August - 13th November 1999.

    OpenAIRE

    1999-01-01

    A prototype low-cost drilling rig was imported to Uganda in August 1999 and handed over to Mpigi District Government. Field trials of this machine were undertaken between 20 th August and 13 th November 1999. This work was enabled through a tripartite Memorandum of Understanding between the Cranfield University/DFID Low Cost well Drilling Project, the Directorate of Water Development (DWD) of the Government of Uganda, and the local Government of Mpigi District. A total of fo...

  10. Burner Rig with an Unattached Duct for Evaluating the Erosion Resistance of Thermal Barrier Coatings

    Science.gov (United States)

    Miller, Robert A.; Kuczmarski, Maria A.; Zhu, Dongming

    2011-01-01

    Extensive computational fluid dynamics (CFD) modeling backed by experimental observation has demonstrated the feasibility of using an unattached duct to increase the velocity and spatial spread of erodent particles exiting from a burner rig. It was shown that gas velocity and temperature are mostly retained if the inner diameter of the unattached duct equaled the exit diameter of the burner rig nozzle. For particles having a mean diameter of 550 millimeters, the modeled velocity attained at a distance 2.0 in. (50.8 millimeters) beyond the exit of a 12 in. (305 millimeters) long duct was approximately twice as large as the velocity the same distance from the nozzle when the duct was not present. For finer particles, the relative enhancement was somewhat less approximately 1.5 times greater. CFD modeling was also used to guide the construction of a device for slowing down the velocity of the particles being injected into the burner rig. This device used a simple 45 degree fitting to slow the particle velocity in the feed line from 20 meters per second, which is in the range needed to convey the particles, to about 3 meters per second just as they are injected into the burner. This lower injection velocity would lessen the severity of the collision of large particles with the wall of the burner liner opposite the injection port, thereby reducing potential damage to the burner liner by high-velocity particles.

  11. Comparison of laser welding conditions of Zircaloy-4 and stainless steel for nuclear fuel irradiation rig

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kahye; Hong, Jintae; Joung, Changyoung; Heo, Sungho [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Various materials for Zircaloy-4, SUS 316L, such as Inconel, are used as a survey rig that has been produced for fuel irradiation testing. Precision sensors, thermocouples, LVDT, and SPND should also be assembled. Therefore, a welding device for connecting them is necessary. With a high density of energy, laser welding can be properly used in a deep permeation, and in precisely welding narrow and deep joints. In particular, it has been applied to other fields such as metal welding. Since the technology bears no pores or cavities, resulting in a clean surface after the welding process, it does not require an 'after-process' such as grinding or polishing, which is useful where high water-tightness is required. Therefore, we developed and researched a special fiber laser welding system for the production of a nuclear research rig. Through the above test, the different conditions of laser welding were found for Zircaloy-4 and AISI 316L used for producing a nuclear fuel research rig, performing the most optimal welding conditions according to the properties of the materials in the future.

  12. Design and construction of a point-contact spectroscopy rig with lateral scanning capability.

    Science.gov (United States)

    Tortello, M; Park, W K; Ascencio, C O; Saraf, P; Greene, L H

    2016-06-01

    The design and realization of a cryogenic rig for point-contact spectroscopy measurements in the needle-anvil configuration is presented. Thanks to the use of two piezoelectric nano-positioners, the tip can move along the vertical (z) and horizontal (x) direction and thus the rig is suitable to probe different regions of a sample in situ. Moreover, it can also form double point-contacts on different facets of a single crystal for achieving, e.g., an interferometer configuration for phase-sensitive measurements. For the later purpose, the sample holder can also host a Helmholtz coil for applying a small transverse magnetic field to the junction. A semi-rigid coaxial cable can be easily added for studying the behavior of Josephson junctions under microwave irradiation. The rig can be detached from the probe and thus used with different cryostats. The performance of this new probe has been tested in a Quantum Design PPMS system by conducting point-contact Andreev reflection measurements on Nb thin films over large areas as a function of temperature and magnetic field.

  13. DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation.

    Directory of Open Access Journals (Sweden)

    Ji-Seung Yoo

    2014-03-01

    Full Text Available RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by regulating double-stranded RNA (dsRNA-dependent protein kinase (PKR activation, which has been shown to be essential for the formation of antiviral stress granule (avSG. We found that DHX36 and PKR form a complex in a dsRNA-dependent manner. By forming this complex, DHX36 facilitates dsRNA binding and phosphorylation of PKR through its ATPase/helicase activity. Using DHX36 KO-inducible MEF cells, we demonstrated that DHX36 deficient cells showed defect in IFN production and higher susceptibility in RNA virus infection, indicating the physiological importance of this complex in host defense. In summary, we identify a novel function of DHX36 as a critical regulator of PKR-dependent avSG to facilitate viral RNA recognition by RIG-I-like receptor (RLR.

  14. DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation.

    Science.gov (United States)

    Yoo, Ji-Seung; Takahasi, Kiyohiro; Ng, Chen Seng; Ouda, Ryota; Onomoto, Koji; Yoneyama, Mitsutoshi; Lai, Janice Ching; Lattmann, Simon; Nagamine, Yoshikuni; Matsui, Tadashi; Iwabuchi, Kuniyoshi; Kato, Hiroki; Fujita, Takashi

    2014-03-01

    RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by regulating double-stranded RNA (dsRNA)-dependent protein kinase (PKR) activation, which has been shown to be essential for the formation of antiviral stress granule (avSG). We found that DHX36 and PKR form a complex in a dsRNA-dependent manner. By forming this complex, DHX36 facilitates dsRNA binding and phosphorylation of PKR through its ATPase/helicase activity. Using DHX36 KO-inducible MEF cells, we demonstrated that DHX36 deficient cells showed defect in IFN production and higher susceptibility in RNA virus infection, indicating the physiological importance of this complex in host defense. In summary, we identify a novel function of DHX36 as a critical regulator of PKR-dependent avSG to facilitate viral RNA recognition by RIG-I-like receptor (RLR).

  15. Pricing strategies, the strength of bidding intentions, and online auction performance: a cross-cultural study.

    Science.gov (United States)

    Peng, Yu-Shu; Jan, Lih-Tsyr

    2009-10-01

    Over the past decade, electronic markets based on the Internet, particularly online auctions, have become popular venues for conducting business. Previous studies often focused on the construction of the best bidding model, while few studies have tried to integrate multiple pricing strategies to predict the probability of closing an auction and the price premium. This study constructs a mediated model to examine the relationship among pricing strategies, the strength of bidding intentions, and online auction performance. The sample consists of 1,055 auctions of iPod MP3 players from eBay Web sites in Hong Kong, Singapore, Belgium, and France. Empirical results show that the pricing strategies directly influence both the probability of closing an auction and the level of price premium. The pricing strategies also indirectly influence the price premium through the mediating effect of the strength of bidding intentions.

  16. A Data-Driven Bidding Model for a Cluster of Price-Responsive Consumers of Electricity

    DEFF Research Database (Denmark)

    Saez Gallego, Javier; Morales González, Juan Miguel; Zugno, Marco;

    2016-01-01

    -response of the cluster. The complex market bid is defined as a series of marginal utility functions plus some constraints on demand, such as maximum pick-up and drop-off rates. The proposed modeling approach also leverages information on exogenous factors that may influence the consumption behavior of the cluster, e......This paper deals with the market-bidding problem of a cluster of price-responsive consumers of electricity. We develop an inverse optimization scheme that, recast as a bilevel programming problem, uses price-consumption data to estimate the complex market bid that best captures the price.......g., weather conditions and calendar effects. We test the proposed methodology for a particular application: forecasting the power consumption of a small aggregation of households that took part in the Olympic Peninsula project. Results show that the price-sensitive consumption of the cluster of flexible loads...

  17. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

    Science.gov (United States)

    Andree, Maria; Seeger, Jens M; Schüll, Stephan; Coutelle, Oliver; Wagner-Stippich, Diana; Wiegmann, Katja; Wunderlich, Claudia M; Brinkmann, Kerstin; Broxtermann, Pia; Witt, Axel; Fritsch, Melanie; Martinelli, Paola; Bielig, Harald; Lamkemeyer, Tobias; Rugarli, Elena I; Kaufmann, Thomas; Sterner-Kock, Anja; Wunderlich, F Thomas; Villunger, Andreas; Martins, L Miguel; Krönke, Martin; Kufer, Thomas A; Utermöhlen, Olaf; Kashkar, Hamid

    2014-10-01

    The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. During apoptosis, XIAP is antagonized by SMAC, which is released from the mitochondria upon caspase-mediated activation of BID. Recent studies suggest that XIAP is involved in immune signaling. Here, we explore XIAP as an important mediator of an immune response against the enteroinvasive bacterium Shigella flexneri, both in vitro and in vivo. Our data demonstrate for the first time that Shigella evades the XIAP-mediated immune response by inducing the BID-dependent release of SMAC from the mitochondria. Unlike apoptotic stimuli, Shigella activates the calpain-dependent cleavage of BID to trigger the release of SMAC, which antagonizes the inflammatory action of XIAP without inducing apoptosis. Our results demonstrate how the cellular death machinery can be subverted by an invasive pathogen to ensure bacterial colonization.

  18. Stochastic Optimal Wind Power Bidding Strategy in Short-Term Electricity Market

    DEFF Research Database (Denmark)

    Hu, Weihao; Chen, Zhe; Bak-Jensen, Birgitte

    2012-01-01

    minimization problem for trading wind power in the short-term electricity market is described, to help the wind power owners optimize their bidding strategy. Stochastic optimization and a Monte Carlo method are adopted to find the optimal bidding strategy for trading wind power in the short-term electricity...... market in order to deal with the uncertainty of the regulation price, the activated regulation of the power system and the forecasted wind power generation. The Danish short-term electricity market and a wind farm in western Denmark are chosen as study cases due to the high wind power penetration here....... Simulation results show that the stochastic optimal bidding strategy for trading wind power in the Danish short-term electricity market is an effective measure to maximize the revenue of the wind power owners....

  19. Stochastic Optimal Wind Power Bidding Strategy in Short-Term Electricity Market

    DEFF Research Database (Denmark)

    Hu, Weihao; Chen, Zhe; Bak-Jensen, Birgitte

    2012-01-01

    minimization problem for trading wind power in the short-term electricity market is described, to help the wind power owners optimize their bidding strategy. Stochastic optimization and a Monte Carlo method are adopted to find the optimal bidding strategy for trading wind power in the short-term electricity....... Simulation results show that the stochastic optimal bidding strategy for trading wind power in the Danish short-term electricity market is an effective measure to maximize the revenue of the wind power owners.......Due to the fluctuating nature and non-perfect forecast of the wind power, the wind power owners are penalized for the imbalance costs of the regulation, when they trade wind power in the short-term liberalized electricity market. Therefore, in this paper a formulation of an imbalance cost...

  20. Simulating GenCo bidding strategies in electricity markets with an agent-based model

    Energy Technology Data Exchange (ETDEWEB)

    Botterud, Audun; Thimmapuram, Prakash R.; Yamakado, Malo

    2005-12-15

    In this paper we use an agent-based simulation model, EMCAS, to analyze market power in electricity markets. We focus on the effect of congestion management on the ability of generating companies (GenCos) to raise prices beyond competitive levels. An 11-node test power system is used to compare a market design based on locational marginal pricing with a market design that uses system marginal pricing and congestion management by counter trading. Bidding strategies based on both physical and economic withholding are compared to a base case with production cost bidding. The results show that unilateral market power is exercised under both pricing mechanisms. However, the largest changes in consumer costs and GenCo profits due to strategic bidding occur under the locational marginal pricing scheme. The analysis also illustrates that agent-based modeling can contribute important insights into the complex interactions between the participants in transmission-constrained electricity markets. (Author)

  1. Identify the costs and benefits of bidding for the hosting of a mega-event

    Institute of Scientific and Technical Information of China (English)

    熊淑一

    2014-01-01

    A mega-event which attracts attention from all over the world might have both positive and negative effect on the hosting city(Syme et al.1989).The aim of this paper is to evaluate the costs and benefits of bidding for the hosting of megaevents.It identified legacies of bidding for the hosting of megaevents from following four aspects,which are economics,public life,infrastructure,and image of the hosting city,with the methods of literature review,logic analysis,examples,and contrast analysis.The result of this study unveiled that when a city bids for hosting a mega-event for the purpose of stimulating its local economic,improving civic pride,developing basic public infrastructures,and enhance its city image to the worldwide,it also needs to pay attention to potential drawbacks of hosting the event,such as debt crisis,interfering the daily life of the public.

  2. Optimal risky bidding strategy for a generating company by self-organising hierarchical particle swarm optimisation

    Energy Technology Data Exchange (ETDEWEB)

    Boonchuay, Chanwit [Energy Field of Study, School of Environment, Resources and Development, Asian Institute of Technology (Thailand); Ongsakul, Weerakorn, E-mail: ongsakul@ait.asi [Energy Field of Study, School of Environment, Resources and Development, Asian Institute of Technology (Thailand)

    2011-02-15

    In this paper, an optimal risky bidding strategy for a generating company (GenCo) by self-organising hierarchical particle swarm optimisation with time-varying acceleration coefficients (SPSO-TVAC) is proposed. A significant risk index based on mean-standard deviation ratio (MSR) is maximised to provide the optimal bid prices and quantities. The Monte Carlo (MC) method is employed to simulate rivals' behaviour in competitive environment. Non-convex operating cost functions of thermal generating units and minimum up/down time constraints are taken into account. The proposed bidding strategy is implemented in a multi-hourly trading in a uniform price spot market and compared to other particle swarm optimisation (PSO). Test results indicate that the proposed SPSO-TVAC approach can provide a higher MSR than the other PSO methods. It is potentially applicable to risk management of profit variation of GenCo in spot market.

  3. Supplier bidding strategy based on non-cooperative game theory concepts in single auction power pools

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dong-Joo [Korea Electrotechnology Research Institute, 665 Naeson2-dong, Uiwang City, Gyeonggi Province 437-808 (Korea); Kim, Balho H. [Hong-Ik University, School of Electronic and Electrical Engineering, 72-1 Sangsu-dong, Mapo-gu, Seoul 121-791 (Korea); Hur, Don [Kwangwoon University, Department of Electrical Engineering, 447-1 Wolgye1-dong, Nowon-gu, Seoul 139-701 (Korea)

    2007-04-15

    In single auction power pools, only generators bid several energy price segments depending on the amount of energy supply, at individual generating companies' (GENCO) own discretion, for every trading interval. Then all selected bidders are paid a uniform Market Clearing Price (MCP). In this paper, it is realized that each GENCO has the complete information on its own payoff as well as the other parties' payoffs, corresponding to each potential combination of choices of strategies by all the players. Specifically, all the suppliers attempt to estimate the others' bids using the concept of Nash equilibrium in the general sense of profit maximization. Under some simplified assumptions, this problem can be modeled as a simultaneous-move game confronted by the bidders. Here, the system demand forecast by competitive sellers is captured for the purpose of constructing the optimal bidding strategy. Finally, a numerical example is presented demonstrating the effectiveness of the proposed solution scheme. (author)

  4. Hydraulic and thermal testing of different helium cooled irradiation rig models for the IFMIF High Flux Test Module

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Christine, E-mail: Christine.Klein@kit.edu; Arbeiter, Frederik; Martin, Thomas; Taubmann, Peter

    2016-03-15

    Highlights: • Two different single 1:1 irradiation rigs inside a mock-up container are presented. • Pressure drops in the single rig minichannels are measured. • Temperature fields are measured under different heater and flow conditions. • Predictability and reproducibility of the cooling flows can be shown. - Abstract: The hydraulic and thermal testing of two different irradiation rig models A and B, differing in the inlet nozzle design, bottom reflector length and steps inside a mock-up container is part of the HFTM validation activities which support the engineering design of the High Flux Test Module. The pressure drops for all models in the test section are measured for overall mass flow rates of 1–12 g/s and different absolute pressures of 1500 hPa and 2500 hPa at the pressure port at the inlet section. The pressure drops in different sections of the experiment and in the single rig minichannels are also measured with additional pressure ports on the surfaces of the rig models. Predictability and reproducibility of the cooling effects of the main cooling channels in the HFTM irradiation zone can be shown. Rig model B with a backward facing step is for high mass flow rates >∼7.5 g/s (this is the operation regime of the HFTM) superior to rig model A. Uniform perfusion of the multiple parallel minichannels of the irradiation rigs by helium gas is of importance to obtain uniform and predictable temperatures. Temperature fields under different heater and flow conditions have been measured.

  5. Federal mineral-lease-bidding data bases versus the real world and vice versa

    Energy Technology Data Exchange (ETDEWEB)

    Lohrenz, J.; Waller, R.A.

    1979-01-01

    From the vantage point of builders and operators of Federal mineral-lease-bidding data bases, users are addressed. Users are a polyglot lot of empiricists, mechanists, and theorists. The users' perfect data base would contain all data needed to examine all bidding theories and predict bidders' behavior using the theories. That ideal data base has not been attained. However, even the richly flawed history of these data bases leads one to the not particularly prescient notion that users, with omnipresent complaints about errors in and lack of data, will keep the data bases functioning by using them.

  6. A Dynamic Analysis of Bid-Ask Spreads with Multiple Trade Sizes

    OpenAIRE

    Shino Takayama; Han Ozsoylev

    2005-01-01

    This paper studies how the trade size and the historical sequence of trades affect bid-ask spreads, investors’ trading strategies, and the market maker’s learning process in a multi-period economy. First, we show that there is a nonzero cut-off size below which informed traders never buy or sell, and that larger trade sizes have positive bid-ask spreads, while smaller sizes do not. Then, we prove that the cut-off size decreases stochastically . We also derive the functional relationship betwe...

  7. 48 CFR 3.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 3.104-4... marking of contractor bid or proposal information and source selection information. (a) Except as... information or source selection information to any person other than a person authorized, in accordance...

  8. 48 CFR 2903.104-5 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 2903.104-5... contractor bid or proposal information and source selection information. (a) Government employees serving in the following positions are authorized access to proprietary or source selection information, but...

  9. 48 CFR 203.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 203.104-4....104-4 Disclosure, protection, and marking of contractor bid or proposal information and source selection information. (d)(3) For purposes of FAR 3.104-4(d)(3) only, DoD follows the...

  10. 48 CFR 1503.104-5 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ... marking of contractor bid or proposal information and source selection information. 1503.104-5 Section... marking of contractor bid or proposal information and source selection information. (a)(1) The Chief of.... 2. I agree to use any proposal information only for evaluation purposes. I agree not to copy...

  11. An analytical Study on Dynamics of Public Procurement System and Bidding-Strategy in Local Contractor's Management

    Science.gov (United States)

    Ninomiya, Hitoshi; Nanerikawa, Susumu

    Public procurement system such as Overall-Evaluation dynamically has been changed on local public works in Japan. However some characteristics of Bidding-Strategy and procurement system have not enough clarified. This paper attempt to analysis for a syatem dynamics and mechanisum of Overall-Evaluation by developing new simulation model focused on Bidding-Strategy, to propose some improvement scenario.

  12. 48 CFR 9904.420 - Accounting for independent research and development costs and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Accounting for independent research and development costs and bid and proposal costs. 9904.420 Section 9904.420 Federal Acquisition... Accounting for independent research and development costs and bid and proposal costs....

  13. 13 CFR 126.601 - What additional requirements must a qualified HUBZone SBC meet to bid on a contract?

    Science.gov (United States)

    2010-01-01

    ... a qualified HUBZone SBC meet to bid on a contract? 126.601 Section 126.601 Business Credit and... requirements must a qualified HUBZone SBC meet to bid on a contract? (a) The Federal Acquisition Regulatory... offer on a specific HUBZone contract, the qualified HUBZone SBC, together with its affiliates, must...

  14. 47 CFR 1.1181 - Authority to prescribe and collect fees for competitive bidding-related services and products.

    Science.gov (United States)

    2010-10-01

    ... competitive bidding-related services and products. 1.1181 Section 1.1181 Telecommunication FEDERAL... § 1.1181 Authority to prescribe and collect fees for competitive bidding-related services and products... prescribe regulations that establish charges for the provision of government services and products....

  15. Discuss the Preparation of Project Bidding and Bidding Strategies Budget%探讨工程投标预算的编制与报价策略

    Institute of Scientific and Technical Information of China (English)

    孔祥慧

    2014-01-01

    在工程建设市场中,投标企业都希望自己的企业能够中标,并且获得良好的信誉和经济效益。然而,工程投标预算的编制和报价是一项严谨且复杂的工作,要保证预算在编制过程中的质量,就需要在编制预算时选择正确的依据。编制人员要充分了解工程的设计图纸和资料,熟悉工程的实际情况,掌握其中的定额,切合实际地进行编制。针对工程投标预算的编制和报价策略进行分析。%In the construction market, bidding companies want their businesses to bid and get a good reputation and economic benefits. However, budget preparation and tender offer engineering is a rigorous and complex work, to ensure the quality of budget preparation process, you need to select the correct basis in preparing the budget. Staffing levels should fully understand the actual situation of the design drawings and data, familiar engineering, master of them fixed, realistically be compiled. In view of the engineering bidding budget preparation and bidding strategies are analyzed.

  16. 36 CFR 223.84 - Small business bid form provisions on sales with specified road construction.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Small business bid form provisions on sales with specified road construction. 223.84 Section 223.84 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM...

  17. 36 CFR 223.86 - Bid restriction on resale of noncompleted contract.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bid restriction on resale of noncompleted contract. 223.86 Section 223.86 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Timber Sale Contracts Advertisement and...

  18. 36 CFR 223.230 - Bid restriction on resale of incomplete contracts, permits, or other instruments.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bid restriction on resale of incomplete contracts, permits, or other instruments. 223.230 Section 223.230 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM...

  19. Bid Optimization for Internet Graphical Ad Auction Systems via Special Ordered Sets

    CERN Document Server

    Wiggins, Ralphe

    2007-01-01

    This paper describes an optimization model for setting bid levels for certain types of advertisements on web pages. This model is non-convex, but we are able to obtain optimal or near-optimal solutions rapidly using branch and cut open-source software. The financial benefits obtained using the prototype system have been substantial.

  20. Accounting protesting and warm glow bidding in Contingent Valuation surveys considering the management of environmental goods

    DEFF Research Database (Denmark)

    Grammatikopoulou, Ioanna; Olsen, Søren Bøye

    2013-01-01

    Based on a Contingent Valuation survey aiming to reveal the willingness to pay (WTP) for conservation of a wetland area in Greece, we show how protest and warm glow motives can be taken into account when modeling WTP. In a sample of more than 300 respondents, we find that 54% of the positive bids...

  1. 47 CFR 101.1107 - Bidding credits for very small businesses, small businesses and entrepreneurs.

    Science.gov (United States)

    2010-10-01

    ..., small businesses and entrepreneurs. 101.1107 Section 101.1107 Telecommunication FEDERAL COMMUNICATIONS... Procedures for LMDS § 101.1107 Bidding credits for very small businesses, small businesses and entrepreneurs.... (c) A winning bidder that qualifies as an entrepreneur, as defined in § 101.1112, or a consortium...

  2. Learning Based Bidding Strategy for HVAC Systems in Double Auction Retail Energy Markets

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yannan; Somani, Abhishek; Carroll, Thomas E.

    2015-07-01

    In this paper, a bidding strategy is proposed using reinforcement learning for HVAC systems in a double auction market. The bidding strategy does not require a specific model-based representation of behavior, i.e., a functional form to translate indoor house temperatures into bid prices. The results from reinforcement learning based approach are compared with the HVAC bidding approach used in the AEP gridSMART® smart grid demonstration project and it is shown that the model-free (learning based) approach tracks well the results from the model-based behavior. Successful use of model-free approaches to represent device-level economic behavior may help develop similar approaches to represent behavior of more complex devices or groups of diverse devices, such as in a building. Distributed control requires an understanding of decision making processes of intelligent agents so that appropriate mechanisms may be developed to control and coordinate their responses, and model-free approaches to represent behavior will be extremely useful in that quest.

  3. Industrial Fuel Gas Demonstration Plant Program. Bid packages for materials (Deliverable No. 28)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    Fixed-price supply type bid packages for materials and/or service essentially are comprised of two parts, namely: (1) a technical requisition of the material, equipment, or service to be supplied; and (2) commercial and legal requirements, normally referred to as terms and conditions. Requisitions, providing technical requirements, for all equipment items identified for the Industrial Fuel Gas Demonstration Plant may be found in the 12 volumes of the Demonstration Plant Mechanical Design. The requisitions have been included within separate sections of the design report, sorted by appropriate plant unit. Combined with any General Notes Requisition and the necessary FWEC Job Standards, these various item requisitions provide all technical information for the prospective vendor to furnish his bid. The terms and conditions (boiler plate) to be included in the bid package identify all the contractual requirements which will be imposed upon the bidder. These requirements cover the conditions he must meet to bid on the particular item as well as the clauses to be included within the eventual purchase order/subcontract. A typical package of such terms and conditions is included.

  4. Automation of Capacity Bidding with an Aggregator Using Open Automated Demand Response

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila; Piette, Mary Ann

    2008-10-01

    This report summarizes San Diego Gas& Electric Company?s collaboration with the Demand Response Research Center to develop and test automation capability for the Capacity Bidding Program in 2007. The report describes the Open Automated Demand Response architecture, summarizes the history of technology development and pilot studies. It also outlines the Capacity Bidding Program and technology being used by an aggregator that participated in this demand response program. Due to delays, the program was not fully operational for summer 2007. However, a test event on October 3, 2007, showed that the project successfully achieved the objective to develop and demonstrate how an open, Web?based interoperable automated notification system for capacity bidding can be used by aggregators for demand response. The system was effective in initiating a fully automated demand response shed at the aggregated sites. This project also demonstrated how aggregators can integrate their demand response automation systems with San Diego Gas& Electric Company?s Demand Response Automation Server and capacity bidding program.

  5. Bid rounds: progress and future prospects; Rodadas de licitacoes: evolucao e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    Amorelli Junior, D.C.; Silva, Paulo Alexandre S.; Campos, Thiago N. [Agencia Nacional do Petroleo, Gas Natural e Biocombustiveis (ANP), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The National Agency of Petroleum, Natural Gas and Biofuels - ANP is an institution integrating the indirect Federal Administration, under the special autarchic regime, as an entity regulating the petroleum industry, linked to the Ministry of Mines and Energy - MME. The Minister of MME is the president of the National Council of Energy Policy - CNPE, which has the attribution of proposing national policies and specific measures to the President of the Republic. The ANP aims at promoting the regulation, contraction and inspection of the economic activities related to the petroleum industry, and shall elaborate the bidding protocols and promote the bidding for the concession of exploration, development and production activities, signing the relevant contracts and inspecting its execution. The Brazilian Bidding Rounds of blocks with exploratory risk, promoted by ANP, included areas from 22 of the 38 main Brazilian sedimentary basins divided into three exploratory models: High Potential Areas, New Frontier Areas and Mature Basins Areas. This work presents the framework evolution obtained in Bid Rounds, analyzing the main results of the auctions, and the future perspectives for management of the exploration and production activities according the national energy policy statements. (author)

  6. The Preterm Infant's Use of Triangular Bids at Three Months, Adjusted Age: Two Case Studies

    Science.gov (United States)

    Hansen, Ellen Saeter

    2011-01-01

    This article focuses on preterm infants' early triangular capacity, restricted to the use of triangular bids in interaction with their parents. An observational setting, the Lausanne Trilogue Play (LTP), is used for studying the patterns of interaction. This is an approach focusing on the family as a whole. These observations are part of a study…

  7. Cooperative Petroleum Contracts of the First Bidding Round are Perfectly Implemented in Tarim Basin

    Institute of Scientific and Technical Information of China (English)

    Pengpeng; Zhang Yirong

    1995-01-01

    @@ Tarim Basin is one of the largest sedimentary basins in the world covering an area of 560 000 square kilometers, with a fairly-good petroleum geological conditions and richaccumulated petroleum resources.Therefore, the southeast part of Tarim Basin was selected as the first bidding rotund area that are divided into five blocks. The coverage area is 72 730 square kilometers in total.

  8. New approach for strategic bidding of Gencos in energy and spinning reserve markets

    Energy Technology Data Exchange (ETDEWEB)

    Soleymani, S. [Sharif University of Technology, Tehran (Iran); Ranjbar, A.M. [Sharif University of Technology, Tehran (Iran); Niroo Research Institute, Tehran (Iran); Shirani, A.R. [Niroo Research Institute, Tehran (Iran)

    2007-07-15

    In restructured and de-regulated power systems, generating companies (Gencos) are responsible for supplying electricity for both energy and reserve markets, which usually operate simultaneously. In this condition, the question is how much and for what price must each Genco generate for each market to maximize its profit, so this paper intends to answer to this question. In this paper, first, the combined energy and reserve markets are considered, and the Nash equilibrium points are determined. Then, the bidding strategies for each Genco at these points will be presented. The bids for the energy and 10 min spinning reserve (TMSR) markets are separated in the second stage, and again, the bidding strategies for each Genco for the two separated markets will be demonstrated. Comparison of the results shows that the separated bidding strategies, while being simplified with the algebraic optimization model and reducing the time consumed, give the same results as the combined ones. The Western System Coordinating Council (WSCC) nine bus test system is employed to illustrate and verify the results of the proposed method. (author)

  9. Application of online bid system%在线开标系统应用研究

    Institute of Scientific and Technical Information of China (English)

    庄圣强; 汤慧敏; 冯海东; 杨云瑞

    2016-01-01

    Guangdong Grid Co Logistics Service Center to carry out the bidding project bid opening mode by field artificial opening mode,subject to the bid opening room location, quantitative restrictions, supervisors,providers across the country must arrive on time at the Guangzhou opening room scene,pay a lot of travel time and cost, resulting in a huge waste of the power grid company,social resources. According to the laws and regulations and the current Internet technology.Members of the studio put forward the technical scheme of online bid opening on the Internet.%广东电网公司招标项目开标模式采用现场人工开标模式,受到开标室地理位置、数量限制,监察人员、全国各地供应商必须按时到达开标室现场,付出大量差旅和时间成本,造成了电网公司、社会资源的巨大浪费。根据法律法规及现有互联网技术,本文提出了在互联网上进行“在线开标”的技术解决方案。

  10. China National Petroleum Corporation Notice for the Second Round of Bidding

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    @@ Authorized by the Government of the People's Republic of China, China National petroleum Corporation (CNPC) hereby announces the commencement of the Second Round of Bidding for the Exploitation of Land Petroleum Resources of P.R. China in Cooperation with Foreign Enterprises.

  11. Bid-Ask Spreads, Trading Volume and Return Volatility: Intraday Evidence from Indian Stock Market

    Directory of Open Access Journals (Sweden)

    Rashmi Ranjan Paital

    2016-01-01

    Full Text Available This paper empirically examines the relationship between stock return volatility, trading volume and bid-ask spread within the scope of mixture of distribution hypothesis (MDH and sequential information arrival hypothesis (SIAH in the Indian stock market using high frequency 5-minute data set over the period of 2 July 2012 to 31 December 2012. This is the first kind of study in India using bid-ask spread as an additional information variable along with trading volume to investigate the relationship with stock return volatility. Our empirical findings provide evidence of a positive contemporaneous relationship between return volatility and trading volume, and also between return volatility and bid-ask spread. Moreover, the results of Granger causality test show that the information content of trading volume and bid-ask spread are useful for predicting stock return volatility. Our results indicate that information arrival to investors tends to follow a sequential rather than a simultaneous process. This finding is consistent with the sequential information arrival hypothesis and contradicts the mixture of distribution hypothesis.

  12. Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.

    Directory of Open Access Journals (Sweden)

    Sébastien Plumet

    Full Text Available BACKGROUND: Double stranded RNA (dsRNA is widely accepted as an RNA motif recognized as a danger signal by the cellular sentries. However, the biology of non-segmented negative strand RNA viruses, or Mononegavirales, is hardly compatible with the production of such dsRNA. METHODOLOGY AND PRINCIPAL FINDINGS: During measles virus infection, the IFN-beta gene transcription was found to be paralleled by the virus transcription, but not by the virus replication. Since the expression of every individual viral mRNA failed to activate the IFN-beta gene, we postulated the involvement of the leader RNA, which is a small not capped and not polyadenylated RNA firstly transcribed by Mononegavirales. The measles virus leader RNA, synthesized both in vitro and in vivo, was efficient in inducing the IFN-beta expression, provided that it was delivered into the cytosol as a 5'-trisphosphate ended RNA. The use of a human cell line expressing a debilitated RIG-I molecule, together with overexpression studies of wild type RIG-I, showed that the IFN-beta induction by virus infection or by leader RNA required RIG-I to be functional. RIG-I binds to leader RNA independently from being 5-trisphosphate ended; while a point mutant, Q299A, predicted to establish contacts with the RNA, fails to bind to leader RNA. Since the 5'-triphosphate is required for optimal RIG-I activation but not for leader RNA binding, our data support that RIG-I is activated upon recognition of the 5'-triphosphate RNA end. CONCLUSIONS/SIGNIFICANCE: RIG-I is proposed to recognize Mononegavirales transcription, which occurs in the cytosol, while scanning cytosolic RNAs, and to trigger an IFN response when encountering a free 5'-triphosphate RNA resulting from a mislocated transcription activity, which is therefore considered as the hallmark of a foreign invader.

  13. Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry.

    Directory of Open Access Journals (Sweden)

    Young Bong Choi

    Full Text Available Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of host cells. For HHV-8, viral interferon regulatory factor-1 (vIRF-1 contributes to this process in part via inhibitory interactions with BH3-only protein (BOP Bim, recently identified as an interaction partner of vIRF-1. Here we recognize that the Bim-binding domain (BBD of vIRF-1 resembles a region (BH3-B of Bid, another BOP, which interacts intramolecularly with the functional BH3 domain of Bid to inhibit it pro-apoptotic activity. Indeed, vIRF-1 was found to target Bid in addition to Bim and to interact, via its BBD region, with the BH3 domain of each. In functional assays, BBD could substitute for BH3-B in the context of Bid, to suppress Bid-induced apoptosis in a BH3-binding-dependent manner, and vIRF-1 was able to protect transfected cells from apoptosis induced by Bid. While vIRF-1 can mediate nuclear sequestration of Bim, this was not the case for Bid, and inhibition of Bid and Bim by vIRF-1 could occur independently of nuclear localization of the viral protein. Consistent with this finding, direct BBD-dependent inactivation by vIRF-1 of Bid-induced mitochondrial permeabilization was demonstrable in vitro and isolated BBD sequences were also active in this assay. In addition to Bim and Bid BH3 domains, BH3s of BOPs Bik, Bmf, Hrk, and Noxa also were found to bind BBD, while those of both pro- and anti-apoptotic multi-BH domain Bcl-2 proteins were not. Finally, the significance of Bid to virus replication was demonstrated via Bid-depletion in HHV-8 infected cells, which enhanced virus production. Together, our data demonstrate and characterize BH3 targeting and associated inhibition of BOP pro-apoptotic activity by vIRF-1 via Bid BH3-B mimicry, identifying a novel mechanism of viral evasion from host cell defenses.

  14. A durability test rig and methodology for erosion-resistant blade coatings in turbomachinery

    Science.gov (United States)

    Leithead, Sean Gregory

    A durability test rig for erosion-resistant gas turbine engine compressor blade coatings was designed, completed and commissioned. Bare and coated 17-4PH steel V103-profile blades were rotated at up to 11500 rpm and impacted with Garnet sand for 5 hours at an average concentration of 2.51 gm3of air , at a blade leading edge Mach number of 0.50. The rig was determined to be an acceptable first stage axial compressor representation. Two types of 16 microm-thick coatings were tested: Titanium Nitride (TiN) and Chromium-Aluminum-Titanium Nitride (CrAlTiN), both applied using an Arc Physical Vapour Deposition technique at the National Research Council in Ottawa, Canada. A Leithead-Allan-Zhao (LAZ) score was created to compare the durability performance of uncoated and coated blades based on mass-loss and blade dimension changes. The bare blades' LAZ score was set as a benchmark of 1.00. The TiN-coated and CrAlTiN-coated blades obtained LAZ scores of 0.69 and 0.41, respectively. A lower score meant a more erosion-resistant coating. Major modes of blade wear included: trailing edge, leading edge and the rear suction surface. Trailing edge thickness was reduced, the leading edge became blunt, and the rear suction surface was scrubbed by overtip and recirculation zone vortices. It was found that the erosion effects of vortex flow were significant. Erosion damage due to reflected particles was not present due to the low blade solidity of 0.7. The rig is best suited for studying the performance of erosion-resistant coatings after they are proven effective in ASTM standardized testing. Keywords: erosion, compressor, coatings, turbomachinery, erosion rate, blade, experimental, gas turbine engine

  15. 工程投标报价的常用技巧%Commonly Used Skills for Engineering Bidding Price Quotations

    Institute of Scientific and Technical Information of China (English)

    王雪芬; 王雪军

    2014-01-01

    Engineering bidding skills involves the whole process of tender offer. The scientific and reasonable use of bidding skills is the key to the whole project bidding quotation. This article first introduces the bidding skill before bid opening, including pre-qualification stage, research the tender stage, on-site inspection stages. Then several engineering bidding skills and their respective scope of application and matters needing attention are introduced. At last, specific engineering bidding cases are used to analyze the skills.%工程投标技巧所包含的内容涉及投标报价过程的全部过程,能否科学、合理地运用投标技巧,是整个工程投标报价工作的关键所在。为此,文章首先介绍了开标前的投标技巧,资格预审阶段、研究标书阶段、现场考察阶段等阶段的投标技巧。然后介绍了几种工程投标技巧及各自的适用范围和注意事项,最后通过具体的工程投标技巧案例分析来说明。

  16. Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression

    Science.gov (United States)

    Zhu, Zixiang; Wang, Guoqing; Yang, Fan; Cao, Weijun; Mao, Ruoqing; Du, Xiaoli; Zhang, Xiangle; Li, Chuntian; Li, Dan; Zhang, Keshan; Shu, Hongbing; Liu, Xiangtao

    2016-01-01

    ABSTRACT The role of retinoic acid-inducible gene I (RIG-I) in foot-and-mouth disease virus (FMDV)-infected cells remains unknown. Here, we showed that RIG-I inhibits FMDV replication in host cells. FMDV infection increased the transcription of RIG-I, while it decreased RIG-I protein expression. A detailed analysis revealed that FMDV leader proteinase (Lpro), as well as 3C proteinase (3Cpro) and 2B protein, decreased RIG-I protein expression. Lpro and 3Cpro are viral proteinases that can cleave various host proteins and are responsible for several of the viral polyprotein cleavages. However, for the first time, we observed 2B-induced reduction of host protein. Further studies showed that 2B-mediated reduction of RIG-I is specific to FMDV, but not other picornaviruses, including encephalomyocarditis virus, enterovirus 71, and coxsackievirus A16. Moreover, we found the decreased protein level of RIG-I is independent of the cleavage of eukaryotic translation initiation factor 4 gamma, the induction of cellular apoptosis, or the association of proteasome, lysosome, and caspase pathways. A direct interaction was observed between RIG-I and 2B. The carboxyl-terminal amino acids 105 to 114 and amino acids 135 to 144 of 2B were essential for the reduction of RIG-I, while residues 105 to 114 were required for the interaction. These data suggest the antiviral role of RIG-I against FMDV and a novel antagonistic mechanism of FMDV that is mediated by 2B protein. IMPORTANCE This study demonstrated that RIG-I could suppress FMDV replication during virus infection. FMDV infection increased the transcriptional expression of RIG-I, while it decreased RIG-I protein expression. FMDV 2B protein interacted with RIG-I and induced reduction of RIG-I. 2B-induced reduction of RIG-I was independent of the induction of the cleavage of eukaryotic translation initiation factor 4 gamma or cellular apoptosis. In addition, proteasome, lysosome, and caspase pathways were not involved in this process

  17. Drilling rig noise assessment model vs. field monitoring results Imperial Oil Resources Cold Lake in-situ bitumen development area

    Energy Technology Data Exchange (ETDEWEB)

    Nixon, J.; MacDonald, T. [Imperial Oil Resources, Calgary, AB (Canada). Cold Lake Projects; Wright, R. [HFP Acoustical Consultants Corp., Calgary, AB (Canada)

    2007-07-01

    Oil and gas companies in Alberta must comply with the noise-emissions standards in the Noise Control Directive 038 of the Alberta Energy and Utilities Board (EUB). Licensees are responsible for risk when choosing sites and designing facilities. As such, they are required to work proactively to minimize potential impacts of new developments and must report existing noise levels. Imperial Oil Resources (IOR) Cold Lake operation is Canada's largest in-situ bitumen development facility which undergoes significant, ongoing development including the addition of up to 10 new multi-well production sites per year. In this study, the following equipment was assessed as a component of the noise impact assessment: the draw works, rotary table and drilling floor operations of a typical pad-drilling rig; the equipment skid for a typical diesel-electric rig, which includes two diesel engines, mud pumps and mud tanks; and, the equipment skid for a typical all electric rig, which includes only the mud pumps and mud tanks. Drilling rig noise measurements taken in 2006 at at two operating drill rigs were compared with 1996 drilling rig noise measurements. Sound level measurements at the U08 and U09 operating drill rigs were completed at distances of 5 m, 10 m, 20 m and 40 m and the measurements were used to calculate sound power levels for the drilling floor. A comparison of predicted sound levels to measured sound levels was then presented. Higher sound power level values in the 2006 measurements were due to equipment noise being centered at the drilling complex as opposed to the rig floor in 1996. The 2006 field monitoring data were then used by HFP Acoustical Consultants to update the predictive model which was provided to IOR in January 2006. The updated sound levels around the electric drilling rigs range from approximately 60 dBA near the edge of the lease up to 83 dBA near the noisiest equipment. It was concluded that the predictions from the model remain conservative and

  18. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.

    Science.gov (United States)

    Diao, Feici; Li, Shu; Tian, Yang; Zhang, Min; Xu, Liang-Guo; Zhang, Yan; Wang, Rui-Peng; Chen, Danying; Zhai, Zhonghe; Zhong, Bo; Tien, Po; Shu, Hong-Bing

    2007-07-10

    Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs produced during viral replication. In this study, we identified DAK, a functionally unknown dihydroacetone kinase, as a specific MDA5-interacting protein. DAK was associated with MDA5, but not RIG-I, under physiological conditions. Overexpression of DAK inhibited MDA5- but not RIG-I- or TLR3-mediated IFN-beta induction. Overexpression of DAK also inhibited cytoplasmic dsRNA and SeV-induced activation of the IFN-beta promoter, whereas knockdown of endogenous DAK by RNAi activated the IFN-beta promoter, and increased cytoplasmic dsRNA- or SeV-triggered activation of the IFN-beta promoter. In addition, overexpression of DAK inhibited MDA5- but not RIG-I-mediated antiviral activity, whereas DAK RNAi increased cytoplasmic dsRNA-triggered antiviral activity. These findings suggest that DAK is a physiological suppressor of MDA5 and specifically inhibits MDA5- but not RIG-I-mediated innate antiviral signaling.

  19. Dynamic Spin Rig Upgraded With a Five- Axis-Controlled Three-Magnetic-Bearing Support System With Forward Excitation

    Science.gov (United States)

    Morrison, Carlos R.; Mehmed, Oral

    2003-01-01

    The NASA Glenn Research Center Dynamic Spin Rig is used for experimental evaluation of vibration analysis methods and dynamic characteristics for rotating systems. Measurements are made while rotors are spun and vibrated in a vacuum chamber. The rig has been upgraded with a new active magnetic bearing rotor support and excitation system. This design is expected to provide operational improvements over the existing rig. The rig will be able to be operated in either the old or new configuration. In the old configuration, two ball bearings support the vertical shaft of the rig, with the test article located between the bearings. Because the bearings operate in a vacuum, lubrication is limited to grease. This limits bearing life and speed. In addition, the old configuration employs two voice-coil electromagnetic shakers to apply oscillatory axial forces or transverse moments to the rotor shaft through a thrust bearing. The excitation amplitudes that can be imparted to the test article with this system are not adequate for components that are highly damped. It is expected that the new design will overcome these limitations.

  20. Roughnecks, rock bits and rigs : the evolution of oil well drilling technology in Alberta, 1883-1970

    Energy Technology Data Exchange (ETDEWEB)

    Gow, A.

    2005-07-01

    This book provides a comprehensive review of the evolving technologies related to oil and gas exploration in the province of Alberta. Oil well drilling technology evolved significantly during the era of conventional oil exploration in the province, from 1883 through 1970. Technologies such as drill bits and power sources were developed largely through trial and error to meet the specific needs of individuals working in the oilfield. The competence and resolve to innovate by drill crews was told through accounts of evolution in drilling processes and equipment, along with personal accounts of those who worked on the rigs. The technology of the oilfield was placed into context with a summary of the history and geology of oil and gas in Alberta. The book also presents a considerate view of events in relation to those who invested in the industry, carried out research drilling and serviced the exploration industry. The first part of the book provides the background to the oil and gas industry. Part 2 examines the earliest technology, the standard cable tool drilling rig, the combination rig and some associated developments in drilling. The third part focuses on the rotary drilling rig and the final part outlines the types of challenges faced by the drillers and the hazards of working on Alberta's rigs. refs., tabs., figs.

  1. CONCENTRIC TUBE-FOULING RIG FOR INVESTIGATION OF FOULING DEPOSIT FORMATION FROM PASTEURISER OF VISCOUS FOOD LIQUID

    Directory of Open Access Journals (Sweden)

    N. I. KHALID

    2013-02-01

    Full Text Available This paper reports the work on developing concentric tube-fouling rig, a new fouling deposit monitoring device. This device can detect and quantify the level of fouling deposit formation. It can also functioning as sampler for fouling deposit study, which can be attached at any food processing equipment. The design is initiated with conceptual design. The rig is designed with inner diameter of 7 cm and with tube length of 37 cm. A spiral insert with 34.5 cm length and with 5.4 cm diameter is fitted inside the tube to ensure the fluid flows around the tube. In this work, the rig is attached to the lab-scale concentric tube-pasteurizer to test its effectiveness and to collect a fouling sample after pasteurization of pink guava puree. Temperature changes are recorded during the pasteurization and the data is used to plot the heat transfer profile. Thickness of the fouling deposit is also measured. The trends for thickness, heat resistance profile and heat transfer profile for concentric tube-fouling rig matched the trends obtained from lab-scale concentric tube-pasteurizer very well. The findings from this work have shown a good potential of this rig however there is a limitation with spiral insert, which is discussed in this paper.

  2. A Thrust Allocation Method for Efficient Dynamic Positioning of a Semisubmersible Drilling Rig Based on the Hybrid Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Luman Zhao

    2015-01-01

    Full Text Available A thrust allocation method was proposed based on a hybrid optimization algorithm to efficiently and dynamically position a semisubmersible drilling rig. That is, the thrust allocation was optimized to produce the generalized forces and moment required while at the same time minimizing the total power consumption under the premise that forbidden zones should be taken into account. An optimization problem was mathematically formulated to provide the optimal thrust allocation by introducing the corresponding design variables, objective function, and constraints. A hybrid optimization algorithm consisting of a genetic algorithm and a sequential quadratic programming (SQP algorithm was selected and used to solve this problem. The proposed method was evaluated by applying it to a thrust allocation problem for a semisubmersible drilling rig. The results indicate that the proposed method can be used as part of a cost-effective strategy for thrust allocation of the rig.

  3. Rigging Test Bed Development for Validation of Multi-Stage Decelerator Extractions

    Science.gov (United States)

    Kenig, Sivan J.; Gallon, John C.; Adams, Douglas S.; Rivellini, Tommaso P.

    2013-01-01

    The Low Density Supersonic Decelerator project is developing new decelerator systems for Mars entry which would include testing with a Supersonic Flight Dynamics Test Vehicle. One of the decelerator systems being developed is a large supersonic ringsail parachute. Due to the configuration of the vehicle it is not possible to deploy the parachute with a mortar which would be the preferred method for a spacecraft in a supersonic flow. Alternatively, a multi-stage extraction process using a ballute as a pilot is being developed for the test vehicle. The Rigging Test Bed is a test venue being constructed to perform verification and validation of this extraction process. The test bed consists of a long pneumatic piston device capable of providing a constant force simulating the ballute drag force during the extraction events. The extraction tests will take place both inside a high-bay for frequent tests of individual extraction stages and outdoors using a mobile hydraulic crane for complete deployment tests from initial pack pull out to canopy extraction. These tests will measure line tensions and use photogrammetry to track motion of the elements involved. The resulting data will be used to verify packing and rigging as well, as validate models and identify potential failure modes in order to finalize the design of the extraction system.

  4. Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity

    Directory of Open Access Journals (Sweden)

    Helene Minyi Liu

    2010-01-01

    Full Text Available Exposure to hepatitis C virus (HCV usually results in persistent infection that often develops into chronic liver disease. Interferon-alpha (IFN treatment comprises the foundation of current approved therapy for chronic HCV infection but is limited in overall efficacy. IFN is a major effector of innate antiviral immunity and is naturally produced in response to viral infection when viral pathogen-associated molecular patterns (PAMPs are recognized as nonself and are bound by cellular pathogen recognition receptors (PRRs, including Toll-like receptors (TLRs and the RIG-I-like receptors (RLRs. Within hepatocytes, RIG-I is a major PRR of HCV infection wherein PAMP interactions serve to trigger intracellular signaling cascades in the infected hepatocyte to drive IFN production and the expression of interferon-stimulated genes (ISGs. ISGs function to limit virus replication, modulate the immune system, and to suppress virus spread. However, studies of HCV-host interactions have revealed several mechanisms of innate immune regulation and evasion that feature virus control of PRR signaling and regulation of hepatic innate immune programs that may provide a molecular basis for viral persistence.

  5. Estimation of Tree Stem Attributes Using Terrestrial Photogrammetry with a Camera Rig

    Directory of Open Access Journals (Sweden)

    Mona Forsman

    2016-03-01

    Full Text Available We propose a novel photogrammetric method for field plot inventory, designed for simplicity and time efficiency on-site. A prototype multi-camera rig was used to acquire images from field plot centers in multiple directions. The acquisition time on-site was less than two minutes. From each view, a point cloud was generated using a novel, rig-based matching of detected SIFT keypoints. Stems were detected in the merged point cloud, and their positions and diameters were estimated. The method was evaluated on 25 hemi-boreal forest plots of a 10-m radius. Due to difficult lighting conditions and faulty hardware, imagery from only six field plots was processed. The method performed best on three plots with clearly visible stems with a 76% detection rate and 0% commission. Diameters could be estimated for 40% of the stems with an RMSE of 2.8–9.5 cm. The results are comparable to other camera-based methods evaluated in a similar manner. The results are inferior to TLS-based methods. However, our method is easily extended to multiple station image schemas, something that could significantly improve the results while retaining low commission errors and time on-site. Furthermore, with smaller hardware, we believe this could be a useful technique for measuring stem attributes in the forest.

  6. Investigation of Flow Conditioners for Compact Jet Engine Simulator Rig Noise Reduction

    Science.gov (United States)

    Doty, Michael J.; Haskin, Henry H.

    2011-01-01

    The design requirements for two new Compact Jet Engine Simulator (CJES) units for upcoming wind tunnel testing lead to the distinct possibility of rig noise contamination. The acoustic and aerodynamic properties of several flow conditioner devices are investigated over a range of operating conditions relevant to the CJES units to mitigate the risk of rig noise. An impinging jet broadband noise source is placed in the upstream plenum of the test facility permitting measurements of not only flow conditioner self-noise, but also noise attenuation characteristics. Several perforated plate and honeycomb samples of high porosity show minimal self-noise but also minimal attenuation capability. Conversely, low porosity perforated plate and sintered wire mesh conditioners exhibit noticeable attenuation but also unacceptable self-noise. One fine wire mesh sample (DP450661) shows minimal selfnoise and reasonable attenuation, particularly when combined in series with a 15.6 percent open area (POA) perforated plate upstream. This configuration is the preferred flow conditioner system for the CJES, providing up to 20 dB of broadband attenuation capability with minimal self-noise.

  7. 76 FR 6154 - Notice of Realty Action: Modified Competitive Bid Sale of Public Lands in Santa Cruz County, CA

    Science.gov (United States)

    2011-02-03

    ... Valuation Services. Under the regulations 43 CFR 2711.3-2, the BLM may limit bidding to certain persons when... including the sale procedures and conditions, appraisal, planning and environmental documents, and a...

  8. The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook.

    Science.gov (United States)

    Stanger, Frédéric V; de Beer, Tjaart A P; Dranow, David M; Schirmer, Tilman; Phan, Isabelle; Dehio, Christoph

    2017-01-03

    The BID (Bep intracellular delivery) domain functions as secretion signal in a subfamily of protein substrates of bacterial type IV secretion (T4S) systems. It mediates transfer of (1) relaxases and the attached DNA during bacterial conjugation, and (2) numerous Bartonella effector proteins (Beps) during protein transfer into host cells infected by pathogenic Bartonella species. Furthermore, BID domains of Beps have often evolved secondary effector functions within host cells. Here, we provide crystal structures for three representative BID domains and describe a novel conserved fold characterized by a compact, antiparallel four-helix bundle topped with a hook. The conserved hydrophobic core provides a rigid scaffold to a surface that, despite a few conserved exposed residues and similarities in charge distribution, displays significant variability. We propose that the genuine function of BID domains as T4S signal may primarily depend on their rigid structure, while the plasticity of their surface may facilitate adaptation to secondary effector functions.

  9. Uranium Mill Tailings Remedial Action Project (UMTRAP), Slick Rock, Colorado, Revision 1. Bid schedule, special conditions, specifications, and subcontract drawings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    This volume contains: bidding requirements; terms and conditions; specifications for Division 1 -- general requirements; specifications for Division 2 -- sitework; specifications for Divisions 5 -- metals; subcontract drawings, (general, Union Carbide processing site, North Continent processing site, and Burro Canyon disposal site).

  10. Browns Park National Wildlife Refuge, Colorado State Lands and Bureau of Land Management : Request for Proposal [Bid Proposal

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This bid proposal proposal from Natural Resource Options, Inc. (a consultation service) is a response to the Browns Park Committee's Request for Proposals on the...

  11. Optimal Bidding Strategies using New Aggregated Demand Model with Particle Swarm Optimization Technique

    Directory of Open Access Journals (Sweden)

    Dr.B.Subramanyam

    2013-02-01

    Full Text Available In this paper, Particle Swarm optimization(PSO and Artificial Bee Colony (ABC algorithms are used to determine the optimal bidding strategy in competitive auction market implementation. The deregulated power industry meets the challenges of increase their profits and also minimize the associadted risks of the system. Themarket includes generating companies(Gencos and large Consumers. The demand prediction of the system has been determined by the neural network, which is trained by using the previous day demand dataset, the training process is achieved by the back propagation algorithm. The fitness of the system compared with PSO and ABC technique, the maximized fitness is the optimal bidding strategy of the system . The results for two techniques will be analyzed in this paper. The implementation of the two techniques could be implemented in theMATLAB Platform.

  12. Bidding strategy based on artificial intelligence for a competitive electric market

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Y.-Y.; Tsai, S.-W.; Weng, M.-T. [Chung Yuan Univ., Dept. of Electrical Engineering, Chung Li (China)

    2001-03-01

    A bidding strategy using a fuzzy-c-mean (FCM) algorithm and the artificial neural network (ANN) was developed for competitive electric markets. The nodal price information was assumed to be released into the market. The FCM was used, first, to classify the daily load pattern into peak, medium-peak and off-peak levels and, secondly, to classify the competitive generation companies (gencos) into less-menacing, possible-menacing and menacing gencos. The back-propagation ANN was used for determining the bidding price for a genco. The FCM results aided in lessening the training data and reducing the ANN input nodes. The IEEE 30-busbar system was used for illustrating the applicability of the proposed method. (Author)

  13. Combining hydro-generation and wind energy. Biddings and operation on electricity spot markets

    Energy Technology Data Exchange (ETDEWEB)

    Angarita, Jorge Marquez; Usaola, Julio Garcia [Universidad Carlos III de Madrid, Department of Power Engineering, Avenida de la Universidad, 30, 28911 Leganes, Madrid (Spain)

    2007-04-15

    Wind generation is growing rapidly in all the world, especially in Europe. The power produced by this kind of generation is difficult to predict and the predictions are not very accurate. In most systems these imbalances are costly. These penalties reduce the revenue for the wind generation company (WGENCOs). An option to solve this problem would be to work together with another agent. In this paper, a combined strategy for bidding and operating in a power exchange is presented. It considers the combination of a WGENCO and a hydro-generation company (HGENCO). The mathematical formulation for the optimal bids and for the optimal operation is presented, as well as results from realistic cases. (author)

  14. Optimal Bidding Strategies for Generation Companies in a Day-Ahead Electricity Market with Risk Management Taken into Account

    Directory of Open Access Journals (Sweden)

    Azmi Saleh

    2009-01-01

    Full Text Available Problem statement: In a competitive electricity market with limited number of producers, Generation Companies (Gencos is facing an oligopoly market rather than a perfect competition. Under oligopoly market environment, each Genco may increase its own profit through a favorable bidding strategy. The objective of a Genco is to maximize its profit and minimize the associated risk. In order to achieve this goal, it is necessary and important for the Genco to make optimal bidding strategies with risk management before bidding into spot market to get an expected high profit, since spot prices are substantially volatile. This study propose a method to build optimal bidding strategies in a day-ahead electricity market with incomplete information and considering both risk management and unit commitment. Approach: The proposed methodology employs the Monte Carlo simulation for modeling a risk management and a strategic behavior of rival. A probability density function (pdf, Value at Risk (VaR and Monte Carlo simulation used to build optimal bidding strategies for a Genco. Results: The result of the proposed method shows that a Genco can build optimal bidding strategies to maximize expected total profit considering unit commitment and risk management. The Genco controls the risk by setting the confidence level. If the Genco increase the confidence level, the expected total VaR of profit decrease. Conclusions/Recommendations: The proposed method for building optimal bidding strategies in a day-ahead electricity market to maximize expected total profit considering unit commitment and risk management is helpful for a Genco to make a decision to submit bidding to the Independent System Operator (ISO.

  15. Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB.

    Science.gov (United States)

    Li, Dong; Sun, Junjun; Liu, Wenfang; Wang, Xuan; Bals, Robert; Wu, Junlu; Quan, Wenqiang; Yao, Yiwen; Zhang, Yu; Zhou, Hong; Wu, Kaiyin

    2016-10-04

    The expression of the retinoic acid-induced G (Rig-G) gene, an all trans retinoic acid (ATRA)-inducible gene, was observed in multiple cancer cells, including lung cancer cells. However, whether Rig-G is a tumor suppressor in lung cancer is unknown. Here, we found that ectopic expression of Rig-G can lead to a significant decrease in proliferation of lung cancer cells, resulting in an inhibition of tumor growth. Rig-G knockdown results in a modest increase in cell proliferation, as well as confers an increase in colony formation. Furthermore, transcriptome and pathway analyses of cancer cells revealed a fundamental impact of Rig-G on various growth signaling pathways, including the NF-κB pathway. Rig-G inhibits NF-κB activity by suppressing STAT3 in lung cancer cells. The downregulation of miR21 and miR181b-1 and subsequent activation of PTEN/Akt and CYLD/IκB signaling axis leading to decreased NF-κB activity required to maintain the tumor-inhibiting effect of Rig-G.. Our findings contribute to a better understanding of the antitumor effect mechanism of Rig-G, as well as offer a novel strategy for lung cancer therapy.

  16. Suggestions on the Writing of Speeches Bidding for Votes from the Perspective of Functional Grammar

    Institute of Scientific and Technical Information of China (English)

    叶瑞娟

    2009-01-01

    This paper carries on a tentative functional discourse analysis of Yang Lan's speech bidding for Olympic Games from Interpersonal, Experiential and Textual Metafunctions, which aims to help readers understand and evaluate the speech regarding its suitability. By revealing how choices of linguistic items in discourse production and comprehension help to meet Yang Lan's purposes of the speech, the writer hopes to provide some guidance to make better speeches bidding for votes. The research shows that,(1) In the Interpersonal Metafunction, positive declarative clauses are dominant in Yang Lan's speech; items about culture are constantly used to be the Subject;"will" appears at a high rate.(2) In the Experiential Metafunction, Material Processes are adopted most frequently in the speech; Mental Processes are in the second position. (3)In the Textual Metafunction, items about culture dominate the Theme; and a "you--we--you" thematic pattern turns up occasionally in the speech. This study has promising implications for speeches bidding for votes as foilows:(1)Positive declarative clauses are recommended to convey information and convince the prospective voters with fact.(2)The focus of the speech should be chosen as the Subject to call the attention of the audience; and the high modal commitment of modal verbal operators can show the addresser's firm determination to finish tasks.(3) Material Processes can emphasize the addresser's getting true action, instead of just stopping in a "slogan"; while a few Mental Processes are always helpful in moving the prospective voters with emotion.(4) The focus of the speech should be frequently chosen to be the Theme; a"you--we--you" thematic pattern helps to create an intimate dialogic style, which can further persuade the audience to share the same proposal of the addresser.[KeyWords] Functional Discourse Analysis; Three Metafunctions; Speeches bidding for votes

  17. To Bid or to Buy?: Online Shoppers’ Preferences for Online Purchasing Channels

    OpenAIRE

    Fan-Chen Tseng

    2010-01-01

    Online retailing is a rapidly expanding business. There are three major purchasing channels for online shoppers to choose when they conduct online purchasing: (1) shopping in online stores, (2) bidding in online auctions, and (3) direct purchasing in online auctions. Each channel has its strengths and weaknesses, and suits different kinds of online shoppers. This article explores the relationships between online shoppers’ lifestyles and their preferences for online purchasing channels. Know...

  18. Eesti tüübid : meie siin maal / Maris Rosenthal

    Index Scriptorium Estoniae

    Rosenthal, Maris

    2009-01-01

    Eesti Rahva Muuseumi ja fotograaf Alar Madissoni projekti "Eesti tüübid" raames valminud fotonäitus "Meie siin maal" Tartus Raadi mõisapargis. Kaasaega dokumenteeriva projekti eesmärgiks oli jäädvustada kõigis Eesti maakondades elavaid eri generatsioonide ja sotsiaalsete rühmade esindajaid ERMi fotokogu täiendamiseks. Meenutusi pildistamistelt 2008. aasta suvel

  19. Cooperation and Competition when Bidding for Complex Projects: Centralized and Decentralized Perspectives

    OpenAIRE

    Skowron, Piotr; Rzadca, Krzysztof; Datta, Anwitaman

    2014-01-01

    To successfully complete a complex project, be it a construction of an airport or of a backbone IT system, agents (companies or individuals) must form a team having required competences and resources. A team can be formed either by the project issuer based on individual agents' offers (centralized formation); or by the agents themselves (decentralized formation) bidding for a project as a consortium---in that case many feasible teams compete for the contract. We investigate rational strategie...

  20. Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.

    Science.gov (United States)

    Mühleisen, A; Giaisi, M; Köhler, R; Krammer, P H; Li-Weber, M

    2014-12-18

    The human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression of the Bcl-2 family of antiapoptotic proteins. In this study, we show that the expression of proapoptotic BH3-only proteins Bim (Bcl-2-interacting mediator of cell death) and Bid (BH3-interacting domain death agonist) is diminished in HTLV-1-infected leukemic cells. Using a Tax-inducible system and a transient overexpression approach, we demonstrate that Tax downregulates Bid and Bim expression at the transcriptional level. We show that reinforced expression of Bim and Bid in HTLV-1-infected T-cell lines sensitizes CD95/TRAIL- and anticancer drug-induced apoptosis. Furthermore, we show that Tax suppresses Bid and Bim expression by enhancing hypoxia-inducible factor-1α (HIF-1α) protein expression. siRNA knockdown of HIF-1α or chemical inhibition of the transactivation activity of HIF-1α resulted in an increase in Bid and Bim expression and, consequently, in an increase in CD95/TRAIL- and anticancer drug-induced apoptosis in HTLV-1-infected leukemic T-cell lines. Our study provides evidence that besides upregulation of prosurvival Bcl-2 proteins, Tax may also confer apoptosis resistance to HTLV-1-infected T cells by suppressing the expression of the proapoptotic BH3-only proteins Bim and Bid.

  1. Estimation of Bid Curves in Power Exchanges using Time-varying Simultaneous-Equations Models

    Science.gov (United States)

    Ofuji, Kenta; Yamaguchi, Nobuyuki

    Simultaneous-equations model (SEM) is generally used in economics to estimate interdependent endogenous variables such as price and quantity in a competitive, equilibrium market. In this paper, we have attempted to apply SEM to JEPX (Japan Electric Power eXchange) spot market, a single-price auction market, using the publicly available data of selling and buying bid volumes, system price and traded quantity. The aim of this analysis is to understand the magnitude of influences to the auctioned prices and quantity from the selling and buying bids, than to forecast prices and quantity for risk management purposes. In comparison with the Ordinary Least Squares (OLS) estimation where the estimation results represent average values that are independent of time, we employ a time-varying simultaneous-equations model (TV-SEM) to capture structural changes inherent in those influences, using State Space models with Kalman filter stepwise estimation. The results showed that the buying bid volumes has that highest magnitude of influences among the factors considered, exhibiting time-dependent changes, ranging as broad as about 240% of its average. The slope of the supply curve also varies across time, implying the elastic property of the supply commodity, while the demand curve remains comparatively inelastic and stable over time.

  2. Understanding Irrigator Bidding Behavior in Australian Water Markets in Response to Uncertainty

    Directory of Open Access Journals (Sweden)

    Alec Zuo

    2014-11-01

    Full Text Available Water markets have been used by Australian irrigators as a way to reduce risk and uncertainty in times of low water allocations and rainfall. However, little is known about how irrigators’ bidding trading behavior in water markets compares to other markets, nor is it known what role uncertainty and a lack of water in a variable and changing climate plays in influencing behavior. This paper studies irrigator behavior in Victorian water markets over a decade (a time period that included a severe drought. In particular, it studies the evidence for price clustering (when water bids/offers end mostly around particular numbers, a common phenomenon present in other established markets. We found that clustering in bid/offer prices in Victorian water allocation markets was influenced by uncertainty and strategic behavior. Water traders evaluate the costs and benefits of clustering and act according to their risk aversion levels. Water market buyer clustering behavior was mostly explained by increased market uncertainty (in particular, hotter and drier conditions, while seller-clustering behavior is mostly explained by strategic behavioral factors which evaluate the costs and benefits of clustering.

  3. Identify the costs and benefits of bidding for the hosting of a mega-event

    Institute of Scientific and Technical Information of China (English)

    熊淑一

    2014-01-01

    A mega-event which attracts attention from all over the world might have both positive and negative effect on the hosting city (Syme et al.1989).The aim of this paper is to evaluate the costs and benefits of bidding for the hosting of mega-events.It identified legacies of bidding for the hosting of mega-events from following four aspects,which are economics,public life,infrastructure,and image of the hosting city,with the methods of literature review,logic analysis,examples,and contrast analysis.The result of this study unveiled that when a city bids for hosting a mega-event for the purpose of stimulating its local economic,improving civic pride,developing basic public infrastructures,and enhance its city image to the worldwide,it also needs to pay attention to potential drawbacks of hosting the event,such as debt crisis,interfering the daily life of the public.

  4. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis.

    Science.gov (United States)

    Simmen, Thomas; Aslan, Joseph E; Blagoveshchenskaya, Anastassia D; Thomas, Laurel; Wan, Lei; Xiang, Yang; Feliciangeli, Sylvain F; Hung, Chien-Hui; Crump, Colin M; Thomas, Gary

    2005-02-23

    The endoplasmic reticulum (ER) and mitochondria form contacts that support communication between these two organelles, including synthesis and transfer of lipids, and the exchange of calcium, which regulates ER chaperones, mitochondrial ATP production, and apoptosis. Despite the fundamental roles for ER-mitochondria contacts, little is known about the molecules that regulate them. Here we report the identification of a multifunctional sorting protein, PACS-2, that integrates ER-mitochondria communication, ER homeostasis, and apoptosis. PACS-2 controls the apposition of mitochondria with the ER, as depletion of PACS-2 causes BAP31-dependent mitochondria fragmentation and uncoupling from the ER. PACS-2 also controls formation of ER lipid-synthesizing centers found on mitochondria-associated membranes and ER homeostasis. However, in response to apoptotic inducers, PACS-2 translocates Bid to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated Bid, the release of cytochrome c, and the activation of caspase-3, thereby causing cell death. Together, our results identify PACS-2 as a novel sorting protein that links the ER-mitochondria axis to ER homeostasis and the control of cell fate, and provide new insights into Bid action.

  5. Characterization of rotavirus RNAs that activate innate immune signaling through the RIG-I-like receptors.

    Directory of Open Access Journals (Sweden)

    Dina Uzri

    Full Text Available In mammalian cells, the first line of defense against viral pathogens is the innate immune response, which is characterized by induction of type I interferons (IFN and other pro-inflammatory cytokines that establish an antiviral milieu both in infected cells and in neighboring uninfected cells. Rotavirus, a double-stranded RNA virus of the Reoviridae family, is the primary etiological agent of severe diarrhea in young children worldwide. Previous studies demonstrated that rotavirus replication induces a MAVS-dependent type I IFN response that involves both RIG-I and MDA5, two cytoplasmic viral RNA sensors. This study reports the isolation and characterization of rotavirus RNAs that activate IFN signaling. Using an in vitro approach with purified rotavirus double-layer particles, nascent single-stranded RNA (ssRNA transcripts (termed in vitro ssRNA were found to be potent IFN inducers. In addition, large RNAs isolated from rotavirus-infected cells six hours post-infection (termed in vivo 6 hr large RNAs, also activated IFN signaling, whereas a comparable large RNA fraction isolated from cells infected for only one hour lacked this stimulatory activity. Experiments using knockout murine embryonic fibroblasts showed that RIG-I is required for and MDA5 partly contributes to innate immune signaling by both in vitro ssRNA and in vivo 6 hr large RNAs. Enzymatic studies demonstrated that in vitro ssRNA and in vivo 6 hr large RNA samples contain uncapped RNAs with exposed 5' phosphate groups. RNAs lacking 2'-O-methylated 5' cap structures were also detected in the in vivo 6 hr large RNA sample. Taken together, our data provide strong evidence that the rotavirus VP3 enzyme, which encodes both guanylyltransferase and methyltransferase activities, is not completely efficient at either 5' capping or 2'-O-methylation of the 5' cap structures of viral transcripts, and in this way produces RNA patterns that activate innate immune signaling through the RIG

  6. Drill-rig noise suppression using the Karhunen-Loéve transform for seismic-while-drilling experiment at Brukunga, South Australia

    Science.gov (United States)

    Sun, Baichun; Bóna, Andrej; Zhou, Binzhong; King, Andrew; Dupuis, Christian; Kepic, Anton

    2016-02-01

    Diamond-impregnated drill bits are known to be low energy vibration seismic sources. With the strong interference from the drill rig, it is difficult to obtain the drill-bit wavefield with a surface receiver array. To overcome the challenge of surface wave interference generated from the rig for seismic-while-drilling (SWD), we need to separate the rig- and bit-generated signals. To this end, we apply two wavefield separation methods, the Karhunen-Loéve (KL) transform and the f - k filter, and compare their performance. The applicability of these methods is based on the drill rig and drill bit having different spatial positions. While the drill-bit spatial position changes during the process of drilling, the drill rig remains stationary. This results in the source wavefields from the drill rig and the drill-bit having different characteristics, and allows us to separate and extract the drill-bit signal. We use a synthetic model to compare the KL transform and f - k filter. Both techniques are robust when the noise wavefield has consistent amplitude moveout. However, for changing amplitudes, such as the rig noise, which has an unrepeatable wavefield due to power amplitude variation, we show that the KL transform performs better in such situations. We also show the results of signal analysis of the SWD experiment data acquired from Brukunga, South Australia. We demonstrate the feasibility of the KL transform in separating the coherent noises from the stationary drill rig in a hard rock drilling environment, particularly emphasising the suppression of the surface and direct waves from the rig. The results show that drill-rig noise can be effectively suppressed in the correlation domain.

  7. Analysis of the Cause of Project Bid-rigging Based on Conspiracy Theory%基于合谋理论的工程串通投标成因探析

    Institute of Scientific and Technical Information of China (English)

    黄严; 杨伟文

    2009-01-01

    用合谋理论对串通投标成因进行分析,指出串通投标形成的决定性因素是串通投标收入和成本.串通投标私下合约依靠一种声誉机制来执行.遏制串通投标的思路是提高串通投标成本.

  8. The effect of virtual bidding on forward premiums in the New York wholesale energy market

    Science.gov (United States)

    Knudsen, Andrew D.

    In many parts of the United States, the power industry has been deregulated and replaced with regional wholesale energy markets, where utilities purchase electricity from generators at competitive market rates for subsequent distribution to customers. Numerous studies have shown that in each of these markets, the price of energy purchased in the Day Ahead (futures) market exceeds the price in the Real Time (spot) market on average. The existence of this "forward premium" is evidence of market inefficiency and may indicate participants' aversion to risk in the Real Time market or the exercise of market power by generators. To address this inefficiency, the New York Independent System Operator introduced a virtual bidding system within its wholesale market, which permitted participants to engage in purely financial transactions and hedge their exposure to risk. The new policy was expected to promote price convergence by allowing bidders to arbitrage expected differences between Day Ahead and Real Time prices. This study examines whether the presence of virtual bidding was associated with a change in the mean value and magnitude of forward premiums in the NYISO energy market. The study applies a GARCH model to hourly pricing data from 2001 to 2009, controlling for temperature and economic activity. The results indicate that prior to 2005, virtual bidding was associated with significantly lower and less volatile forward premiums in New York's five most congested zones but with increased premiums in the remaining less congested zones. However, when the entire period from 2001 to 2009 is examined, the results suggest that prices have become significantly more divergent in the presence of virtual bidding. Closer examination of the data reveals a dramatic increase in forward premium volatility across all zones beginning in 2005 that is not accounted for by temperature or economic activity and may have biased the results. This study attempts to account for this unexplained

  9. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

    Directory of Open Access Journals (Sweden)

    Koji Onomoto

    Full Text Available Retinoic acid inducible gene I (RIG-I-like receptors (RLRs function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular localization of RIG-I in response to viral infection using newly generated anti-RIG-I antibody. Immunohistochemical analysis revealed that RLRs localized in virus-induced granules containing stress granule (SG markers together with viral RNA and antiviral proteins. Because of similarity in morphology and components, we termed these aggregates antiviral stress granules (avSGs. Influenza A virus (IAV deficient in non-structural protein 1 (NS1 efficiently generated avSGs as well as IFN, however IAV encoding NS1 produced little. Inhibition of avSGs formation by removal of either the SG component or double-stranded RNA (dsRNA-dependent protein kinase (PKR resulted in diminished IFN production and concomitant enhancement of viral replication. Furthermore, we observed that transfection of dsRNA resulted in IFN production in an avSGs-dependent manner. These results strongly suggest that the avSG is the locus for non-self RNA sensing and the orchestration of multiple proteins is critical in the triggering of antiviral responses.

  10. Influence of twin and multi-rig trawl systems on CPUE in the Danish Norway lobster (Nephrops norvegicus) fishery

    DEFF Research Database (Denmark)

    Feekings, Jordan P.; Berg, Casper Willestofte; Krag, Ludvig Ahm;

    2016-01-01

    analyse catchrates of four target species, Norway lobster (Nephrops norvegicus), cod (Gadus morhua), plaice (Pleuronectesplatessa) and haddock (Melanogrammus aeglefinus), to try and understand how the use of multi-rig trawlshave altered catch rates within the Danish demersal trawl fishery over the last 16...

  11. The Thermal-hydraulic Performance Test Report for the Non-instrumented Irradiation Test Rig of Annular Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Lee, Kang Hee; Shin, Chang Hwan

    2008-09-15

    This report presents the results of pressure drop test, vibration test and endurance test for the non-instrumented rig using the irradiation test in HANARO of the double cooled annular fuel which were designed and fabricated by KAERI. From the out-pile thermal hydraulic tests, corresponding to the pressure drop of 200 kPa is measured to be about 9.72 kg/sec. Vibration frequency for the non-instrumented rig ranges from 5.0 to 10.7 kg/s. RMS(Root Mean Square) displacement for non-instrumented rig is less than 11.73 m, and the maximum displacement is less than 54.87m. The flow rate for endurance test were 10.5 kg/s, which was 110% of 9.72 kg/s. And the endurance test was carried out for 3 days. The test results found not to the wear and satisfied to the limits of pressure drop, flow rate, vibration and wear in the non-instrumented rig. This test was performed at the FIVPET facility.

  12. High Pressure Burner Rig Testing of Advanced Environmental Barrier Coatings for Si3N4 Turbine Components

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Pastel, Robert T.

    2007-01-01

    Advanced thermal and environmental barrier coatings are being developed for Si3N4 components for turbine engine propulsion applications. High pressure burner rig testing was used to evaluate the coating system performance and durability. Test results demonstrated the feasibility and durability of the coating component systems under the simulated engine environments.

  13. Investigation of piston ring – cylinder liner dry wear using a block-on-ring test rig

    DEFF Research Database (Denmark)

    Bihlet, Uffe; Klit, Peder; Felter, Christian L.;

    material combinations for piston rings and cylinder liners are examined using a block-on-ring test rig. An accelerated wear test run without lubricant is used. Results show that the morphology of cast iron is an important parameter affecting the wear resistance of the material. It is also demonstrated...

  14. 33 CFR 155.400 - Platform machinery space drainage on oceangoing fixed and floating drilling rigs and other...

    Science.gov (United States)

    2010-07-01

    ... Elimination System (NPDES) permit issued in accordance with section 402 of the Clean Water Act and 40 CFR... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Platform machinery space drainage... machinery space drainage on oceangoing fixed and floating drilling rigs and other platforms. (a) No...

  15. A Comparison Between Measured and Predicted Hydrodynamic Damping for a Jack-Up Rig Model

    DEFF Research Database (Denmark)

    Laursen, Thomas; Rohbock, Lars; Jensen, Jørgen Juncher

    1996-01-01

    An extensive set of measurements funded by the EU project Large Scale Facilities Program has been carried out on a model of a jack-up rig at the Danish Hydraulic Institute. The test serieswere conducted by MSC and include determination of base shears and overturning moments in both regular...... and irregular waves.In the paper these results will be compared with theoretical predictions based on two different methods. The first is time simulation procedure using various stretching methods for the wavekinematics above the still water level and applying both the relative and absolute velocityassumption...... in Morison's equation for the wave load. The second procedure is a non-linear, single degree-of-freedom method making use of thetheory of diffusion processes. This procedure is able to account for the spectral content in therandom waves and requires much lesser computational effort than the time simulation...

  16. Risk Management for Complex Calculations: EuSpRIG Best Practices in Hybrid Applications

    CERN Document Server

    Cernauskas, Deborah; VanVliet, Ben

    2008-01-01

    As the need for advanced, interactive mathematical models has increased, user/programmers are increasingly choosing the MatLab scripting language over spreadsheets. However, applications developed in these tools have high error risk, and no best practices exist. We recommend that advanced, highly mathematical applications incorporate these tools with spreadsheets into hybrid applications, where developers can apply EuSpRIG best practices. Development of hybrid applications can reduce the potential for errors, shorten development time, and enable higher level operations. We believe that hybrid applications are the future and over the course of this paper, we apply and extend spreadsheet best practices to reduce or prevent risks in hybrid Excel/MatLab applications.

  17. Optimization of inverse model identification for multi-axial test rig control

    Directory of Open Access Journals (Sweden)

    Müller Tino

    2016-01-01

    Full Text Available Laboratory testing of multi-axial fatigue situations improves repeatability and allows a time condensing of tests which can be carried out until component failure, compared to field testing. To achieve realistic and convincing durability results, precise load data reconstruction is necessary. Cross-talk and a high number of degrees of freedom negatively affect the control accuracy. Therefore a multiple input/multiple output (MIMO model of the system, capturing all inherent cross-couplings is identified. In a first step the model order is estimated based on the physical fundamentals of a one channel hydraulic-servo system. Subsequently, the structure of the MIMO model is optimized using correlation of the outputs, to increase control stability and reduce complexity of the parameter optimization. The identification process is successfully applied to the iterative control of a multi-axial suspension rig. The results show accurate control, with increased stability compared to control without structure optimization.

  18. Bridge Maintenance Robotic Arm:Mechanical Technique to Reduce the Nozzle Force of a Sandblastine Rig

    Institute of Scientific and Technical Information of China (English)

    Nathan Kirchner; Gavin Paul; D.K. Liu

    2006-01-01

    This paper describes a mechanical technique to reduce the nozzle reaction force of a sandblasting rig. A theoretical evaluation of the magnitudes and direction of action of typical sandblasting nozzle forces has been conducted and a technique for exploiting available energy in order to reduce the magnitude of the forces at the nozzle has been developed.Experimental results from a variety of tests in different configurations have confirmed the theoretically determined force magnitude's accuracy and shown that forces of up to 106N can be present in typical sandblasting operations. The results have also shown that an up to 77% reduction of force at the nozzle can be achieved by applying the developed mechanicaltechnique.

  19. Fatigue life on a full scale test rig: Forged versus cast wind turbine rotor shafts

    Science.gov (United States)

    Herrmann, J.; Rauert, T.; Dalhoff, P.; Sander, M.

    2016-09-01

    To reduce uncertainties associated with the fatigue life of the highly safety relevant rotor shaft and also to review today's design practice, the fatigue behaviour will be tested on a full scale test rig. Until now tests on full scale wind turbine parts are not common. Therefore, a general lack of experience on how to perform accelerated life time tests for those components exists. To clarify how to transfer real conditions to the test environment, the arrangements and deviations for the upcoming experimental test are discussed in detail. In order to complete investigations of weight saving potentials, next to getting a better comprehension of the fatigue behaviour by executing a full scale test, a further outcome are suggestions for the usage of cast and forged materials regarding the fatigue and the remaining life of the rotor shaft. It is shown, that it is worthwhile to think about a material exchange for the forged rotor shaft.

  20. Light as a key driver of freshwater biofouling surface roughness in an experimental hydrocanal pipe rig.

    Science.gov (United States)

    Ravizza, Matilde; Giosio, Dean; Henderson, Alan; Hovenden, Mark; Hudson, Monica; Salleh, Sazlina; Sargison, Jane; Shaw, Jennifer L; Walker, Jessica; Hallegraeff, Gustaaf

    2016-07-01

    Biofouling in canals and pipelines used for hydroelectric power generation decreases the flow capacity of conduits. A pipeline rig was designed consisting of test sections of varying substrata (PVC, painted steel) and light levels (transparent, frosted, opaque). Stalk-forming diatoms were abundant in both the frosted and transparent PVC pipes but negligible in the painted steel and opaque PVC pipes. Fungi were slightly more abundant in the painted steel pipe but equally present in all the other pipes while bacterial diversity was similar in all pipes. Photosynthetically functional biofouling (mainly diatoms) was able to develop in near darkness. Different biological fouling compositions generated differing friction factors. The highest friction factor was observed in the transparent pipe (densest diatom fouling), the lowest peak friction for the opaque PVC pipe (lowest fouling biomass), and with the painted steel pipe (high fouling biomass, but composed of fungal and bacterial crusts) being intermediate between the opaque and frosted PVC pipes.

  1. Development of the Compact Jet Engine Simulator from concept to useful test rig

    Science.gov (United States)

    Hoedebecke, Blake Louis

    Two Compact Jet Engine Simulator (CJES) units were designed for integrated wind tunnel acoustic experiments involving a Hybrid Wing Body (HWB) vehicle. To meet the 5.8% scale of the HWB model, Ultra Compact Combustor technology from the Air Force Research Laboratory was used. The CJES units were built and integrated with a control system in the NASA Langley Low Speed Aeroacoustic Wind Tunnel. The combustor liners, plug--vane and flow conditioner components were built in-house at Langley Research Center. The operation of the CJES units was mapped and fixes found for combustor instability tones and rig flow noise. The original concept remained true, but the internal hardware evolved through out the process. The CJES units sucssfully completed the HWB validation test and can be used for acoustic testing or propulsion integration studies that require jet engines.

  2. Rotating Rig Development for Droplet Deformation/Breakup and Impact Induced by Aerodynamic Surfaces

    Science.gov (United States)

    Feo, A.; Vargas, M.; Sor, A.

    2012-01-01

    This work presents the development of a Rotating Rig Facility by the Instituto Nacional de Tecnica Aeroespacial (INTA) in cooperation with the NASA Glenn Research Center. The facility is located at the INTA installations near Madrid, Spain. It has been designed to study the deformation, breakup and impact of large droplets induced by aerodynamic bodies. The importance of these physical phenomena is related to the effects of Supercooled Large Droplets in icing clouds on the impinging efficiency of the droplets on the body, that may change should these phenomena not be taken into account. The important variables and the similarity parameters that enter in this problem are presented. The facility's components are described and some possible set-ups are explained. Application examples from past experiments are presented in order to indicate the capabilities of the new facility.

  3. Non Self-conjugate Strings, Singular Strings and Rigged Configurations in the Heisenberg Model

    CERN Document Server

    Deguchi, Tetsuo

    2014-01-01

    It is observed that there exists a different kind of string solutions in the isotropic Heisenberg spin 1/2 chain starting from $N=12$, where the central rapidity of the odd strings become complex making the strings non self conjugate individually. We show that there are at most (N-2)/2 singular highest weight solutions for M=4, M=5, and for N\\geq 2M and at most (N^2-6N+8)/8 singular solutions for M=6 , M=7 and for N\\geq 2M in an even length chain. Correspondence of the non self conjugate string as well as singular string solutions with the Rigged configurations is also discussed.

  4. Non self-conjugate strings, singular strings and rigged configurations in the Heisenberg model

    Science.gov (United States)

    Deguchi, Tetsuo; Ranjan Giri, Pulak

    2015-02-01

    We observe a different type of complex solutions in the isotropic spin-1/2 Heisenberg chain starting from N = 12, where the central rapidity of some of the odd-length strings becomes complex so that not all the strings self-conjugate individually. We show that there are at most (N - 2)/2 singular solutions for M = 4, M = 5 down-spins and at most (N2 - 6N + 8)/8 singular solutions for M = 6, M = 7 down-spins in an even-length chain with N ⩾ 2M. Correspondence of the non self-conjugate string solutions and the singular string solutions to the rigged configurations has also been shown.

  5. Study on the collision detection method between the 2-arm drill rig arms and the roadway

    Directory of Open Access Journals (Sweden)

    Fuxiang ZHANG

    2015-12-01

    Full Text Available In order to achieve the automation drilling of the improved CMJ2-27 drill, kinematic analysis of the drill rig is conducted aiming the collision between the arms and the roadway during the operation process. By suing the Denavit-Hartenberg (D-H method, the transformation matrix of coordinate system is obtained, then the coordinates of each joint and the ends are derived. The collision detection approach between the arm and the roadway is given. Theoretical calculation and the motion simulation experiment are conducted by using the detection method for a 88-hole drilling program for a mine. The research results show that the method is feasible and has the characteristics of simple procedures and high efficiency.

  6. C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map

    Directory of Open Access Journals (Sweden)

    Yuzhalin AE

    2012-02-01

    Full Text Available Anton G Kutikhin, Arseniy E YuzhalinDepartment of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian FederationAbstract: The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like receptors. They are key sensors for a number of infectious agents, some of which are oncogenic, and they launch an immune response against them, normally promoting their eradication. Inherited variations in genes encoding these receptors and proteins and their signaling pathways may affect their function, possibly modulating cancer risk and features of cancer progression. There are numerous studies investigating the association of single nucleotide polymorphisms within or near genes encoding Toll-like receptors and NOD-like receptors, cancer risk, and features of cancer progression. However, there is an almost total absence of articles analyzing the correlation between polymorphisms of genes encoding C-type lectin receptors and RIG-I-like receptors and cancer risk or progression. Nevertheless, there is some evidence supporting the hypothesis that inherited C-type lectin receptor and RIG-I-like receptor variants can be associated with increased cancer risk. Certain C-type lectin receptors and RIG-I-like receptors recognize pathogen-associated molecular patterns of potentially oncogenic infectious agents, and certain polymorphisms of genes encoding C-type lectin receptors and RIG-I-like receptors may have functional consequences at the molecular level that can lead to association of such single nucleotide polymorphisms with risk or progression of some diseases that may modulate cancer risk, so these gene polymorphisms may affect cancer risk indirectly. Polymorphisms of genes encoding C-type lectin receptors and RIG-I-like receptors thereby may be correlated with a risk of lung, oral, esophageal, gastric, colorectal, and liver cancer, as well as nasopharyngeal carcinoma

  7. Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.

    Directory of Open Access Journals (Sweden)

    Ricardo Rajsbaum

    Full Text Available Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses encode for non-structural 1 (NS1 proteins that are more efficient in suppressing the host immune response. The NS1 protein inhibits type-I interferon (IFN production partly by blocking the TRIM25 ubiquitin E3 ligase-mediated Lys63-linked ubiquitination of the viral RNA sensor RIG-I, required for its optimal downstream signaling. In order to understand possible mechanisms of viral adaptation and host tropism, we examined the ability of NS1 encoded by human (Cal04, avian (HK156, swine (SwTx98 and mouse-adapted (PR8 influenza viruses to interact with TRIM25 orthologues from mammalian and avian species. Using co-immunoprecipitation assays we show that human TRIM25 binds to all tested NS1 proteins, whereas the chicken TRIM25 ortholog binds preferentially to the NS1 from the avian virus. Strikingly, none of the NS1 proteins were able to bind mouse TRIM25. Since NS1 can inhibit IFN production in mouse, we tested the impact of TRIM25 and NS1 on RIG-I ubiquitination in mouse cells. While NS1 efficiently suppressed human TRIM25-dependent ubiquitination of RIG-I 2CARD, NS1 inhibited the ubiquitination of full-length mouse RIG-I in a mouse TRIM25-independent manner. Therefore, we tested if the ubiquitin E3 ligase Riplet, which has also been shown to ubiquitinate RIG-I, interacts with NS1. We found that NS1 binds mouse Riplet and inhibits its activity to induce IFN-β in murine cells. Furthermore, NS1 proteins of human but not swine or avian viruses were able to interact with human Riplet, thereby suppressing RIG-I ubiquitination. In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production.

  8. 医疗设备招投标过程中常见问题与对策%Problems and Countermeasures of Medical Equipment Tendering and Bidding

    Institute of Scientific and Technical Information of China (English)

    黄祖勇

    2014-01-01

    本文从招标文件编制、评标专家、招标代理机构、供应商投标文件编制等过程分析医疗设备招投标过程中存在的常见问题与对策,以提高招投标的规范化管理。%In order to improve the standardization of the bidding management, this paper analyzes the problems existed in the medical equipment bidding process including bidding document compilation, the bid evaluation experts, bidding agency, supplier document for bidding and so on, then presents corresponding countermeasures.

  9. Validation of RELAP5 model of experimental test rig simulating the natural convection in MTR research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Khedr, A.; Abdel-Latif, Salwa H. [Nuclear and Radiological Regulatory Authority, Cairo (Egypt); Abdel-Hadi, Eed A. [Benha Univ., Cairo (Egypt). Shobra Faculty of Engineering; D' Auria, F. [Pisa Univ. (Italy)

    2016-03-15

    In an attempt to understand the built-up of natural circulation in MTR pool type upward flow research reactors after loss of power, an experimental test rig was built to simulate the loop of natural circulation in MTR reactors. The test rig consisting of two vertically oriented branches, in one of them the core is simulated by two rectangular, electrically heated, parallel channels. The other branch simulates the part of the return pipe that participates in the development of core natural circulation. In the first phase of the work, many experimental runs at different conditions of channel's power and branch's initial temperatures are performed. The channel's coolant and surface temperatures were measured. The measurements and their interpretation were published by the first three authors. In the present work the thermal hydraulic behavior of the test rig is complemented by theoretical analysis using RELAP5 Mod 3.3 system code. The analysis consisting of two parts; in the first part RELAP5 model is validated against the measured values and in the second part some of the other not measured hydraulic parameters are predicted and analyzed. The test rig is typically nodalized and an input dick is prepared. In spite of the low pressure of the test rig, the results show that RELAP5 qualitatively predicts the thermal hydraulic behaviour and the accompanied phenomenon of flow inversion of such facilities. Quantitatively, there is a difference between the predicted and measured values especially the channel's surface temperature. This difference may be return to the uncertainties in initial conditions of experimental runs, the position of the thermocouples which buried inside the heat structure, and the heat transfer package in RELAP5.

  10. Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I.

    Directory of Open Access Journals (Sweden)

    Gretja Schnell

    Full Text Available Viral infection of mammalian cells triggers the innate immune response through non-self recognition of pathogen associated molecular patterns (PAMPs in viral nucleic acid. Accurate PAMP discrimination is essential to avoid self recognition that can generate autoimmunity, and therefore should be facilitated by the presence of multiple motifs in a PAMP that mark it as non-self. Hepatitis C virus (HCV RNA is recognized as non-self by RIG-I through the presence of a 5'-triphosphate (5'-ppp on the viral RNA in association with a 3' poly-U/UC tract. Here we define the HCV PAMP and the criteria for RIG-I non-self discrimination of HCV by examining the RNA structure-function attributes that impart PAMP function to the poly-U/UC tract. We found that the 34 nucleotide poly-uridine "core" of this sequence tract was essential for RIG-I activation, and that interspersed ribocytosine nucleotides between poly-U sequences in the RNA were required to achieve optimal RIG-I signal induction. 5'-ppp poly-U/UC RNA variants that stimulated strong RIG-I activation efficiently bound purified RIG-I protein in vitro, and RNA interaction with both the repressor domain and helicase domain of RIG-I was required to activate signaling. When appended to 5'-ppp RNA that lacks PAMP activity, the poly-U/UC U-core sequence conferred non-self recognition of the RNA and innate immune signaling by RIG-I. Importantly, HCV poly-U/UC RNA variants that strongly activated RIG-I signaling triggered potent anti-HCV responses in vitro and hepatic innate immune responses in vivo using a mouse model of PAMP signaling. These studies define a multi-motif PAMP signature of non-self recognition by RIG-I that incorporates a 5'-ppp with poly-uridine sequence composition and length. This HCV PAMP motif drives potent RIG-I signaling to induce the innate immune response to infection. Our studies define a basis of non-self discrimination by RIG-I and offer insights into the antiviral therapeutic

  11. Policy Rules and Bidding Behaviour in the Ethiopian Foreign Exchange Auction Policy Rules and Bidding Behaviour in the Ethiopian Foreign Exchange Auction

    Directory of Open Access Journals (Sweden)

    Janine Aron

    1998-03-01

    Full Text Available Ethiopia adopted a repeated Dutch auction for foreign exchange in May, 1993, for dedicated imports by the private and the state sectors. Various African countries with rudimentary financial systems and thin foreign exchange markets have successfully employed auctions in transition from centralised, controlled systems to decentralised interbank markets. This paper characterises the rules, regime shifts and auction outcomes in Ethiopia. It is emphasised that institutional micro-design and operation of an auction can have important macroeconomic consequences during of an auction can have important macroeconomic consequences during liberalisation. Models for the Central Bank’s supply rules for pre-announced supply of dollars in fortnightly can later weekly auctions, confirm the objective was to stabilise the exchange rate (the marginal auction price in a thin market around depreciating trends. Bidders were able to learn the supply rules, clustering their bids around predicted target rates. Using a method novel in auction empirical literature, bidders’ learning in repeated auctions is examined via the adjustment to equilibrium in error correction equations for the bid spread. Robust models for a similar learning process were found across both frequency regimes; but learning was faster where the exchange rate target was more transparent and uncertainty lower. Thus, a fairly stable depreciation was achieved over four years, despite considerable regime shifts from trade liberalisation, the progressive lifting of auction entry barriers, increased frequency of auctions, fiscal and other seasonality in demand, and temporary price shocks in coffee export earnings. Ethiopia adopted a repeated Dutch auction for foreign exchange in May, 1993, for dedicated imports by the private and the state sectors. Various African countries with rudimentary financial systems and thin foreign exchange markets have successfully employed auctions in transition from

  12. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

    DEFF Research Database (Denmark)

    Erler, Janine Terra; Cawthorne, Christopher J; Williams, Kaye J;

    2004-01-01

    of the Bcl-2 protein family. Oxygen deprivation of human colon cancer cells in vitro provoked decreased mRNA and protein levels of proapoptotic Bid and Bad. Hypoxia-inducible factor 1 (HIF-1) was dispensable for the down-regulation of Bad but required for that of Bid, consistent with the binding of HIF-1......alpha to a hypoxia-responsive element (positions -8484 to -8475) in the bid promoter. Oxygen deprivation resulted in proteosome-independent decreased expression of Bax in vitro, consistent with a reduction in global translation efficiency. The physiological relevance of Bid and Bax down...

  13. Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection

    Directory of Open Access Journals (Sweden)

    Rong Jiang

    2014-01-01

    Full Text Available Japanese encephalitis virus (JEV infection can cause central nervous system disease with irreversible neurological damage in humans and animals. Evidence suggests that overactivation of microglia leads to greatly increased neuronal damage during JEV infection. However, the mechanism by which JEV induces the activation of microglia remains unclear. Toll-like receptor 3 (TLR3 and retinoic acid-inducible gene I (RIG-I can recognize double-stranded RNA, and their downstream signaling results in production of proinflammatory mediators. In this study, we investigated the roles of TLR3 and RIG-I in the inflammatory response caused by JEV infection in the mouse microglial cell line. JEV infection induced the expression of TLR3 and RIG-I and the activation of extracellular signal-regulated kinase (ERK and p38 mitogen-activated protein kinase (p38MAPK. Knockdown of TLR3 and RIG-I attenuated activation of ERK, p38MAPK, activator protein 1 (AP-1, and nuclear factor κB (NF-κB. Secretion of TNF-α, IL-6, and CCL-2, which was induced by JEV, was reduced by TLR3 and RIG-I knockdown and inhibitors of phosphorylated ERK and p38MAPK. Furthermore, viral proliferation was increased following knockdown of TLR3 and RIG-I. Our findings suggest that the signaling pathways of TLR3 and RIG-I play important roles in the JEV-induced inflammatory response of microglia.

  14. Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling.

    Science.gov (United States)

    Morosky, Stefanie A; Zhu, Jianzhong; Mukherjee, Amitava; Sarkar, Saumendra N; Coyne, Carolyn B

    2011-08-12

    Cytoplasmic caspase recruiting domain (CARD)-containing molecules often function in the induction of potent antimicrobial responses in order to protect mammalian cells from invading pathogens. Retinoic acid-induced gene-I (RIG-I) and nucleotide binding oligomerization domain 2 (NOD2) serve as key factors in the detection of viral and bacterial pathogens, and in the subsequent initiation of innate immune signals to combat infection. RIG-I and NOD2 share striking similarities in their cellular localization, both localize to membrane ruffles in non-polarized epithelial cells and both exhibit a close association with the junctional complex of polarized epithelia. Here we show that RIG-I and NOD2 not only colocalize to cellular ruffles and cell-cell junctions, but that they also form a direct interaction that is mediated by the CARDs of RIG-I and multiple regions of NOD2. Moreover, we show that RIG-I negatively regulates ligand-induced nuclear factor-κB (NF-κB) signaling mediated by NOD2, and that NOD2 negatively regulates type I interferon induction by RIG-I. We also show that the three main Crohn disease-associated mutants of NOD2 (1007fs, R702W, G908R) form an interaction with RIG-I and negatively regulate its signaling to a greater extent than wild-type NOD2. Our results show that in addition to their role in innate immune recognition, RIG-I and NOD2 form a direct interaction at actin-enriched sites within cells and suggest that this interaction may impact RIG-I- and NOD2-dependent innate immune signaling.

  15. Guía BID de apoyo a proyectos de seguridad vial

    OpenAIRE

    Alejandro Taddia; Elena de la Peña

    2012-01-01

    Presentación de Elena de la Peña de la Asociación Española de la Carretera y Alejandro Taddia, especialista de Transporte del BID donde se muestra esta Guía interactiva para preparación de proyectos de seguridad vial en el contexto latinoamericano. Se realizó durante el Congreso Iberoamericano de Seguridad Vial (CISEV) III de Bogotá DC. Para acceder al recurso mencionado en la presentación, consulte el campo "Related URL" más abajo.

  16. Robust optimisation for self-scheduling and bidding strategies of hybrid CSP-fossil power plants

    DEFF Research Database (Denmark)

    Pousinho, H.M.I.; Contreras, J.; Pinson, P.

    2015-01-01

    -schedule under the worst-case realisation of uncertainties due to the electricity market prices and the thermal production from the solar field (SF). These uncertainties are modelled by asymmetric prediction intervals around average values. Additionally, a budget parameter is used to parameterise the degree...... of conservatism of the decision. The decision provides the optimal bidding strategies consisting in supply functions built not only for different budget parameter values, but also for different emission allowance levels. Finally, a realistic case study is presented to show the effectiveness of the proposed...

  17. The System of Public Acquisitions by Means of Electronic Bids in the Light of European Regulations

    Directory of Open Access Journals (Sweden)

    Costantin Roman

    2007-01-01

    Full Text Available E-commerce can lead in many different ways to cost reduction in case of a supplier and can subsequently increase the competition potential of a company. As for the competition mechanism, such changes produce significant modifications within a market economy. The Internet renders the possibility of creating business contacts in a rapid and geographically independent manner, as well as possibilities of obtaining data and realizing transactions within the world’s economy. Public acquisitions by means of dynamic systems and electronic bids are currently one of the significant areas of electronic commerce.

  18. New Dynamic Spin Rig Capabilities Used to Determine Rotating Blade Dynamics

    Science.gov (United States)

    Provenza, Andrew J.

    2004-01-01

    The Dynamic Spin Rig Facility at the NASA Glenn Research Center is used to determine the structural response of rotating engine components without the effects of aerodynamic loading. Recently, this rig's capabilities were enhanced through the replacement of grease-lubricated ball bearings with magnetic bearings. Magnetic bearings offer a number of advantages--the most important here being that they not only fully support the rotor system, but excite it as well. Three magnetic bearings support the rotor and provide five axes of controlled motion: an x- and y-axis translation at each of two radial bearings and a z-axis translation in the vertical or axial direction. Sinusoidal excitation (most commonly used) can be imparted on the rotor through the radial magnetic bearings in either a fixed or rotating frame of reference. This excitation is added directly to the magnetic bearing control output. Since the rotor is fully levitated, large translations and rotations of the rotor system can be achieved. Some of the capabilities of this excitation system were determined and reported. The accelerations obtained at the tip of a titanium flat plate test article versus the swept sine excitation sent to both radial bearings in phase and perpendicular to the plane containing the two blades are shown. Recent tests required the excitation of fundamental bending and torsional blade resonances at rotor speeds up to 10,000 rpm. Successful fixed synchronous rotation of the excitation signal provided the best detectable blade resonant vibrations at excitation frequencies up to 1100 Hz for the particular blades of interest. A noncontacting laser measurement system was used to collect blade-tip motions. From these data, the amplitude and frequency of the motion could be determined as well as the blade damping properties. Damping could be determined using two methods: (1) free decay and (2) curve fitting the vibration amplitude as a function of frequency in and around the resonance of

  19. Modelling the nonlinear behaviour of an underplatform damper test rig for turbine applications

    Science.gov (United States)

    Pesaresi, L.; Salles, L.; Jones, A.; Green, J. S.; Schwingshackl, C. W.

    2017-02-01

    Underplatform dampers (UPD) are commonly used in aircraft engines to mitigate the risk of high-cycle fatigue failure of turbine blades. The energy dissipated at the friction contact interface of the damper reduces the vibration amplitude significantly, and the couplings of the blades can also lead to significant shifts of the resonance frequencies of the bladed disk. The highly nonlinear behaviour of bladed discs constrained by UPDs requires an advanced modelling approach to ensure that the correct damper geometry is selected during the design of the turbine, and that no unexpected resonance frequencies and amplitudes will occur in operation. Approaches based on an explicit model of the damper in combination with multi-harmonic balance solvers have emerged as a promising way to predict the nonlinear behaviour of UPDs correctly, however rigorous experimental validations are required before approaches of this type can be used with confidence. In this study, a nonlinear analysis based on an updated explicit damper model having different levels of detail is performed, and the results are evaluated against a newly-developed UPD test rig. Detailed linear finite element models are used as input for the nonlinear analysis, allowing the inclusion of damper flexibility and inertia effects. The nonlinear friction interface between the blades and the damper is described with a dense grid of 3D friction contact elements which allow accurate capturing of the underlying nonlinear mechanism that drives the global nonlinear behaviour. The introduced explicit damper model showed a great dependence on the correct contact pressure distribution. The use of an accurate, measurement based, distribution, better matched the nonlinear dynamic behaviour of the test rig. Good agreement with the measured frequency response data could only be reached when the zero harmonic term (constant term) was included in the multi-harmonic expansion of the nonlinear problem, highlighting its importance

  20. Inquiry on capital construction bidding of universities%高校基本建设招标工作探讨

    Institute of Scientific and Technical Information of China (English)

    李发国

    2015-01-01

    结合高校建设工程管理的现状,分析了高校基本建设项目的优缺点,并对高校建设工程招标的原则和方式进行了论述,提出了招标中的问题与不足,促使高校基本建设招标工作的健康发展。%Combining with university construction engineering management status,the paper analyzes merits and defects of capital university con-struction project. It describes engineering bidding principles and methods,and points out bidding problems and defects,so as to promote healthy development of capital university bidding.

  1. On bidding and pricing strategies and skills%投标报价策略与技巧

    Institute of Scientific and Technical Information of China (English)

    谢彬兴

    2011-01-01

    According to the bidding and pricing status of the current engineering bill model, the paper explores the bidding strategies and skills, illustrates the main bidding strategies, including the low-price strategy, the reasonable optimization strategy and the future strategy, and indicates the unbalanced unit cost method and the sudden price adjustment method, so as to direct the practice.%针对目前工程量清单报价模式下招标现状,探讨了投标报价策略及技巧,分别阐述了低价策略,合理优化策略及未来策略等几种主要的投标策略,并着重阐述了不平衡单价法和突然调价法两种技巧,以期指导实践。

  2. 施工企业投标报价的技巧%Skills of Bidding and Quotation for Construction Enterprises

    Institute of Scientific and Technical Information of China (English)

    郑洪川

    2015-01-01

    投标策略和报价技巧在企业最终获得利润多少的问题上,起着举足轻重的作用。本文通过对报价策略的分析,投标技巧的介绍,施工企业只有结合自身实际情况才能在激烈市场竞争中立于不败之地。%The bidding strategies and quotation skills have important significance for the final profit of enterprises. Through the analysis of bidding strategy and the introduction of quotation skill, this paper puts forward that in order to be in an unassailable position in the fierce market competition, construction enterprises must be based on their actual situation in bidding.

  3. Foreign awakenings: rig work in war-torn Sudan convinces Canadians their civilized version of industry is needed

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, A.

    2000-05-01

    Experiences of some Canadian geologists working in Sudan are described. Glad to be back in Canada after several years of exploration work for various international exploration companies, they have fond memories of the people, who for the most part live under very primitive conditions, and constant exposure to the ravages of tribal wars. They characterize the attitude of Canadians working in Sudan towards the native population as one that puts high values on human rights, safety, work ethics, and individual responsibility. They defend Canadian presence in these far-off regions as beneficial to the native population, by bringing Canadian standards and a civilized version of industry to an area that has seen very little of that in the past. In contrast to the situation on Canadian rigs, on Chinese oil rigs favoritism and racism are the rule; the Chinese do not see that humanitarian issues are any of their concerns.

  4. RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.

    Directory of Open Access Journals (Sweden)

    A M A Nasirudeen

    Full Text Available Dengue virus (DV infection is one of the most common mosquito-borne viral diseases in the world. The innate immune system is important for the early detection of virus and for mounting a cascade of defense measures which include the production of type 1 interferon (IFN. Hence, a thorough understanding of the innate immune response during DV infection would be essential for our understanding of the DV pathogenesis. A recent application of the microarray to dengue virus type 1 (DV1 infected lung carcinoma cells revealed the increased expression of both extracellular and cytoplasmic pattern recognition receptors; retinoic acid inducible gene-I (RIG-I, melanoma differentiation associated gene-5 (MDA-5 and Toll-like receptor-3 (TLR3. These intracellular RNA sensors were previously reported to sense DV infection in different cells. In this study, we show that they are collectively involved in initiating an effective IFN production against DV. Cells silenced for these genes were highly susceptible to DV infection. RIG-I and MDA5 knockdown HUH-7 cells and TLR3 knockout macrophages were highly susceptible to DV infection. When cells were silenced for only RIG-I and MDA5 (but not TLR3, substantial production of IFN-β was observed upon virus infection and vice versa. High susceptibility to virus infection led to ER-stress induced apoptosis in HUH-7 cells. Collectively, our studies demonstrate that the intracellular RNA virus sensors (RIG-I, MDA5 and TLR3 are activated upon DV infection and are essential for host defense against the virus.

  5. Scientific Drilling with the Sea Floor Drill Rig MeBo

    Directory of Open Access Journals (Sweden)

    Gerold Wefer

    2007-09-01

    Full Text Available In March 2007 the sea floor drill rig MeBo (short for “Meeresboden-Bohrgerät”, ‘sea floor drill rig’ in German returned from a 17-day scientific cruise with the new German research vessel Maria S. Merian. Four sites between 350 m and 1700 m water depth were sampled at the continental slope off Morocco by push coring and rotary drilling. Up to 41.5-m-long sediment cores were recovered from Miocene, Pliocene, and Pleistocene marls. MeBo bridges the gapbetween conventional sampling methods from standard multipurpose research vessels (gravity corer, piston corer, dredges and drill ships. Most bigger research vessels will be able to support deployment of the MeBo. Since the drill system can be easily transported within 20-ft containers, worldwide operation from vessels of opportunity is possible. With the MeBo a new system is available for marine geosciences that allows the recovery of high quality samples from soft sediments and hard rock from the deep sea withoutrelying on the services of expensive drilling vessels.

  6. Applications of rigged Hilbert spaces in quantum mechanics and signal processing

    Science.gov (United States)

    Celeghini, E.; Gadella, M.; del Olmo, M. A.

    2016-07-01

    Simultaneous use of discrete and continuous bases in quantum systems is not possible in the context of Hilbert spaces, but only in the more general structure of rigged Hilbert spaces (RHS). In addition, the relevant operators in RHS (but not in Hilbert space) are a realization of elements of a Lie enveloping algebra and support representations of semigroups. We explicitly construct here basis dependent RHS of the line and half-line and relate them to the universal enveloping algebras of the Weyl-Heisenberg algebra and su(1, 1), respectively. The complete sub-structure of both RHS and of the operators acting on them is obtained from their algebraic structures or from the related fractional Fourier transforms. This allows us to describe both quantum and signal processing states and their dynamics. Two relevant improvements are introduced: (i) new kinds of filters related to restrictions to subspaces and/or the elimination of high frequency fluctuations and (ii) an operatorial structure that, starting from fix objects, describes their time evolution.

  7. Heat Flux and Wall Temperature Estimates for the NASA Langley HIFiRE Direct Connect Rig

    Science.gov (United States)

    Cuda, Vincent, Jr.; Hass, Neal E.

    2010-01-01

    An objective of the Hypersonic International Flight Research Experimentation (HIFiRE) Program Flight 2 is to provide validation data for high enthalpy scramjet prediction tools through a single flight test and accompanying ground tests of the HIFiRE Direct Connect Rig (HDCR) tested in the NASA LaRC Arc Heated Scramjet Test Facility (AHSTF). The HDCR is a full-scale, copper heat sink structure designed to simulate the isolator entrance conditions and isolator, pilot, and combustor section of the HIFiRE flight test experiment flowpath and is fully instrumented to assess combustion performance over a range of operating conditions simulating flight from Mach 5.5 to 8.5 and for various fueling schemes. As part of the instrumentation package, temperature and heat flux sensors were provided along the flowpath surface and also imbedded in the structure. The purpose of this paper is to demonstrate that the surface heat flux and wall temperature of the Zirconia coated copper wall can be obtained with a water-cooled heat flux gage and a sub-surface temperature measurement. An algorithm was developed which used these two measurements to reconstruct the surface conditions along the flowpath. Determinations of the surface conditions of the Zirconia coating were conducted for a variety of conditions.

  8. An improved Harmony Search algorithm for optimal scheduling of the diesel generators in oil rig platforms

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, Parikshit; Kumar, Rajesh; Panda, S.K.; Chang, C.S. [Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576 (Singapore)

    2011-02-15

    Harmony Search (HS) algorithm is music based meta-heuristic optimization method which is analogous with the music improvisation process where musician continue to polish the pitches in order to obtain better harmony. The paper focuses on the optimal scheduling of the generators to reduce the fuel consumption in the oil rig platform. The accurate modeling of the specific fuel consumption is significant in this optimization. The specific fuel consumption has been modeled using cubic spline interpolation. The SFC curve is non-linear and discrete in nature, hence conventional methods fail to give optimal solution. HS algorithm has been used for optimal scheduling of the generators of both equal and unequal rating. Furthermore an Improved Harmony Search (IHS) method for generating new solution vectors that enhances accuracy and convergence rate of HS has been employed. The paper also focuses on the impacts of constant parameters on Harmony Search algorithm. Numerical results show that the IHS method has good convergence property. Moreover, the fuel consumption for IHS algorithm is lower when compared to HS and other heuristic or deterministic methods and is a powerful search algorithm for various engineering optimization problems. (author)

  9. Control Study for Five-axis Dynamic Spin Rig Using Magnetic Bearings

    Science.gov (United States)

    Choi, Benjamin; Johnson, Dexter; Provenza, Andrew; Morrison, Carlos; Montague, Gerald

    2003-01-01

    The NASA Glenn Research Center (GRC) has developed a magnetic bearing system for the Dynamic Spin Rig (DSR) with a fully suspended shaft that is used to perform vibration tests of turbomachinery blades and components under spinning conditions in a vacuum. Two heteropolar radial magnetic bearings and a thrust magnetic bearing and the associated control system were integrated into the DSR to provide magnetic excitation as well as non-contact mag- netic suspension of a 15.88 kg (35 lb) vertical rotor with blades to induce turbomachinery blade vibration. For rotor levitation, a proportional-integral-derivative (PID) controller with a special feature for multidirectional radial excitation worked well to both support and shake the shaft with blades. However, more advanced controllers were developed and successfully tested to determine the optimal controller in terms of sensor and processing noise reduction, smaller rotor orbits, more blade vibration amplitude, and energy savings for the system. The test results of a variety of controllers that were demonstrated up to 10.000 rpm are shown. Furthermore, rotor excitation operation and conceptual study of active blade vibration control are addressed.

  10. Comparison Analysis Between Nevada and TSS Using a Jet Engine Exhaust Nozzle Test Rig

    Science.gov (United States)

    Baumeister, Joseph F.; Yuko, James R.

    1999-01-01

    Thermal analysis in both simple and complex models can require calculating the propagation of radiant energy to and from multiple surfaces. This can be accomplished through simple estimation techniques or complex computationally intense computer modeling simulations. Currently there are a variety of computer analysis techniques used to simulate the propagation of radiant energy, each having advantages and disadvantages. The major objective of this effort was to compare two ray tracing radiation propagation analysis programs (NEVADA and TSS) Net Energy Verification and Determination Analyzer and Thermal Synthesizer System with experimental data. Results from a non-flowing, electrically heated test rig was used to verify the calculated radiant energy propagation from a nozzle geometry that represents an aircraft propulsion nozzle system. In general the programs produced comparable overall results, and results slightly higher then the experimental data. Upon inspection of individual radiation interchange factors, differences were evident and would have been magnified if a more radical model temperature profile was analyzed. Bidirectional reflectivity data (BRDF) was not used do to modeling limitations in TSS. For code comparison purposes, this nozzle geometry represents only one case for one set of analysis conditions. Since each computer code has advantages and disadvantages bases on scope, requirements, and desired accuracy, the usefulness of this single case study may be limiting.

  11. Modeling of Laser Vaporization and Plume Chemistry in a Boron Nitride Nanotube Production Rig

    Science.gov (United States)

    Gnoffo, Peter A.; Fay, Catharine C.

    2012-01-01

    Flow in a pressurized, vapor condensation (PVC) boron nitride nanotube (BNNT) production rig is modeled. A laser provides a thermal energy source to the tip of a boron ber bundle in a high pressure nitrogen chamber causing a plume of boron-rich gas to rise. The buoyancy driven flow is modeled as a mixture of thermally perfect gases (B, B2, N, N2, BN) in either thermochemical equilibrium or chemical nonequilibrium assuming steady-state melt and vaporization from a 1 mm radius spot at the axis of an axisymmetric chamber. The simulation is intended to define the macroscopic thermochemical environment from which boron-rich species, including nanotubes, condense out of the plume. Simulations indicate a high temperature environment (T > 4400K) for elevated pressures within 1 mm of the surface sufficient to dissociate molecular nitrogen and form BN at the base of the plume. Modifications to Program LAURA, a finite-volume based solver for hypersonic flows including coupled radiation and ablation, are described to enable this simulation. Simulations indicate that high pressure synthesis conditions enable formation of BN vapor in the plume that may serve to enhance formation of exceptionally long nanotubes in the PVC process.

  12. Perforated mechanism of a water line outlet tee pipe for an oil well drilling rig

    Directory of Open Access Journals (Sweden)

    Peng Cheng-hong

    2015-10-01

    Full Text Available A corroded tee pipe belonging to a 10-in new separator water line outlet installed in an offshore oil well drilling rig was investigated. The configuration of the large corroded pit had the shape of an imperfect horse's hoof with a completely corroded interior and a honeycomb-like cavity. There is a badly corroded pit at the welded seam at the joint connecting the tee pipe and flange. The material strength of the tee pipe meets the requirement of ASTM-A234 Gr. WPR, but its chemical composition does not meet the stipulated requirements. A deformed streamline structure or twin crystal in the ferrite phase can be seen near the surface or sub-surface of the perforated corrosion puncture edge. The micro-hardness is also different from that of the original material. The SEM results show that the puncture appears to have been a mode of quasi-cleavage fractures with secondary cracks along the direction of the crystal grain; thus, the failure has the features of mechanical and chemical corrosion. The corroded surface contains high amounts of O, C, and N, as well as S, Cl, Si, Na, Mg, Al, K, Ti, etc., all of which are corrosion products caused by sea water. The penetrating puncture hole at the turn of the tee pipe is likely the result of cavitation erosion accompanied by chemical/electrochemical corrosion, and the corrosion on the seam connecting the tee pipe and flange is likely the result of electrochemical corrosion.

  13. A radiological survey of the Eğrigöz granitoid, Western Anatolia/Turkey.

    Science.gov (United States)

    Canbaz Öztürk, B; Yaprak, G; Çam, N F; Candan, O

    2015-06-01

    A radiological survey of the granitoid areas throughout Western Anatolia was conducted during 2007-14. As a part of this radiological survey, this article presents results obtained from Eğrigöz pluton, which lies in the northeastern region of Western Anatolia. In the investigated area, the activity measurements of the natural gamma-emitting radionuclides ((226)Ra, (232)Th and (40)K) in the granitic rock samples and soils have been carried out by means of the NaI(Tl) gamma-ray spectrometry system. The activity concentrations of the relevant natural radionuclides in the granite samples appeared in the ranges as follows: (226)Ra, 28-95 Bq kg(-1); (232)Th, 50-122 Bq kg(-1) and (40)K, 782-1365 Bq kg(-1), while the typical ranges of the (226)Ra, (232)Th and (40)K activities in the soil samples were found to be 7-184, 11-174 and 149-1622 Bq kg(-1), respectively. Based on the available data, the radiation hazard parameters associated with the surveyed rocks/soils are calculated. The corresponding absorbed dose rates in air from all those radionuclides were always much lower than 200 nGy h(-1) and did not exceed the typical range of worldwide average values noted in the UNSCEAR (2000) report. Furthermore, the data are also used for the mapping of the surface soil activity of natural radionuclides and the corresponding gamma dose rates of the surveyed area.

  14. Biannular Airbreathing Nozzle Rig (BANR) facility checkout and plug nozzle performance test data

    Science.gov (United States)

    Cummings, Chase B.

    2010-09-01

    The motivation for development of a supersonic business jet (SSBJ) platform lies in its ability to create a paradigm shift in the speed and reach of commercial, private, and government travel. A full understanding of the performance capabilities of exhaust nozzle configurations intended for use in potential SSBJ propulsion systems is critical to the design of an aircraft of this type. Purdue University's newly operational Biannular Airbreathing Nozzle Rig (BANR) is a highly capable facility devoted to the testing of subscale nozzles of this type. The high accuracy, six-axis force measurement system and complementary mass flowrate measurement capabilities of the BANR facility make it rather ideally suited for exhaust nozzle performance appraisal. Detailed accounts pertaining to methods utilized in the proper checkout of these diagnostic capabilities are contained herein. Efforts to quantify uncertainties associated with critical BANR test measurements are recounted, as well. Results of a second hot-fire test campaign of a subscale Gulfstream Aerospace Corporation (GAC) axisymmetric, shrouded plug nozzle are presented. Determined test article performance parameters (nozzle thrust efficiencies and discharge coefficients) are compared to those of a previous test campaign and numerical simulations of the experimental set-up. Recently acquired data is compared to published findings pertaining to plug nozzle experiments of similar scale and operating range. Suggestions relating to the future advancement and improvement of the BANR facility are provided. Lessons learned with regards to test operations and calibration procedures are divulged in an attempt to aid future facility users, as well.

  15. Burner Rig Hot Corrosion of Five Ni-Base Alloys Including Mar-M247

    Science.gov (United States)

    Nesbitt, James A.; Helmink, R.; Harris, K.; Erickson, G.

    2000-01-01

    The hot corrosion resistance of four new Ni-base superalloys was compared to that of Mar-M247 by testing in a Mach 0.3 burner rig at 900 C for 300 1-hr cycles. While the Al content was held the same as in the Mar-M247, the Cr and Co levels in the four new alloys were decreased while other strengthening elements (Re, Ta) were increased. Surprisingly, despite their lower Cr and Co contents, the hot corrosion behavior of all four new alloys was superior to that of the Mar-M247 alloy. The Mar-M247 alloy began to lose weight almost immediately whereas the other four alloys appeared to undergo an incubation period of 50-150 1-hr cycles. Examination of the cross-sectional microstructures showed regions of rampant corrosion attack (propagation stage) in all five alloys after 300 1-hr cycles . This rampant corrosion morphology was similar for each of the alloys with Ni and Cr sulfides located in an inner subscale region. The morphology of the attack suggests a classic "Type I", or high temperature, hot corrosion attack.

  16. Matrine inhibits proliferation and induces apoptosis via BID-mediated mitochondrial pathway in esophageal cancer cells.

    Science.gov (United States)

    Wang, Qiao; Du, Haoxin; Geng, Guojun; Zhou, Huan; Xu, Minying; Cao, Hanwei; Zhang, Bing; Song, Gang; Hu, Tianhui

    2014-05-01

    Matrine, as a member of Sophora family, is an alkaloid found in plants, and produces plethora pharmacological effects, including anti-cancer effects. However, the mechanism involved remains largely unknown. This study is conducted to investigate the anti-cancer mechanisms of matrine in human esophageal cancer in vitro and in vivo. In human esophageal cancer cell Eca-109, matrine significantly decreased the cell viability in a dose-dependent manner, and induced apoptosis as well as cell cycle arrest in G0/G1 phase by up-regulation of P53 and P21. The expression of several apoptosis-related proteins in cells and tumor tissues were evaluated by Western blot analysis. We found that matrine induced cell apoptosis by down-regulation of the ratio of BCL-2/BID and increasing activation of caspase-9. Further studies indicated that matrine induced apoptosis of Eca-109 was through the mitochondria-mediated internal pathway, but not by death receptor-mediated extrinsic apoptotic pathway, which was confirmed by the fact that Bid translocated from the nucleus to mitochondria during the process of the apoptosis induced by matrine. In vivo study found that matrine effectively inhibited the tumor formation of Eca-109 cells in nude mice. Our study suggests that matrine could serve as a potential novel agent from natural products to treat esophageal cancer.

  17. Application of Q-learning with temperature variation for bidding strategies in market based power systems

    Energy Technology Data Exchange (ETDEWEB)

    Naghibi-Sistani, M.B.; Akbarzadeh-Tootoonchi, M.R.; Javidi-Dashte Bayaz, M.H.; Rajabi-Mashhadi, H. [Department of Electrical Engineering, Ferdowsi University of Mashhad, P.O. Box 91775-1111, Mashhad (Iran)

    2006-07-15

    The electric power industry is confronted with restructuring in which the operation scheduling is going to be decided based on a competitive market. In this new arrangement, bidding strategy has become a major issue. Participants in this deregulated energy market place may be able to compete better by choosing a suitable bidding strategy for trading electricity. Different classical methods for decision making in the uncertain environment of the market can be applied to select a suitable strategy. Most of these methods, such as game theory, that insure reaching the best solution for all market participants, require a lot of information about the other market players and the market. However, in the real market place only a little information, such as the spot price, is available for all participants. In this paper, a modified reinforcement learning based on temperature variation has been first proposed and then applied to determine the optimal strategy for a power supplier in the electricity market. A Pool-Co model has been considered here, and the simulation results are shown to be the same as those of standard game theory. Adaptation of the method in the presence of parameter variation has been verified as well. The main advantage of the proposed method is that no information about other participants is required. Furthermore, our investigation shows that even if all participants use this method, they will stay in Nash equilibrium. (author)

  18. Using and comparing metaheuristic algorithms for optimizing bidding strategy viewpoint of profit maximization of generators

    Science.gov (United States)

    Mousavi, Seyed Hosein; Nazemi, Ali; Hafezalkotob, Ashkan

    2015-12-01

    With the formation of the competitive electricity markets in the world, optimization of bidding strategies has become one of the main discussions in studies related to market designing. Market design is challenged by multiple objectives that need to be satisfied. The solution of those multi-objective problems is searched often over the combined strategy space, and thus requires the simultaneous optimization of multiple parameters. The problem is formulated analytically using the Nash equilibrium concept for games composed of large numbers of players having discrete and large strategy spaces. The solution methodology is based on a characterization of Nash equilibrium in terms of minima of a function and relies on a metaheuristic optimization approach to find these minima. This paper presents some metaheuristic algorithms to simulate how generators bid in the spot electricity market viewpoint of their profit maximization according to the other generators' strategies, such as genetic algorithm (GA), simulated annealing (SA) and hybrid simulated annealing genetic algorithm (HSAGA) and compares their results. As both GA and SA are generic search methods, HSAGA is also a generic search method. The model based on the actual data is implemented in a peak hour of Tehran's wholesale spot market in 2012. The results of the simulations show that GA outperforms SA and HSAGA on computing time, number of function evaluation and computing stability, as well as the results of calculated Nash equilibriums by GA are less various and different from each other than the other algorithms.

  19. BID-ASK SPREAD DAN PERIODE KEPEMILIKAN SAHAM PADA PERUSAHAAN LQ-45

    Directory of Open Access Journals (Sweden)

    Vinus Maulina

    2011-10-01

    Full Text Available Global crisis gives quite big impact to the Indonesian Stock Exchange and also changes the investor behavior as well. Fundamental exchange which is considered fragile becomes instability threat and reflects uncertain condition. This research aims to analyze and explain empirically the impact of variance return, trading volume, stock prices and return shares toward bid-ask spread which is the measurement of asymmetrical information cost, also the impact of variance return, market value, bid-ask spread and dividend pay out towards common shares holding periods in Indonesia Stock Exchange and some dominant variable that affect them.The findings of this research strengthen the presumption that in conducting the investment, investors in Indonesian Stock Exchange is more oriented to short term investment by expecting more on common shares than dividend. Most investors keep their ownership in common shares in Indonesian Stock Exchange for two years. Besides, the efficient investment strategy which optimizes profit is “switching strategy”, following the market movement every time exactly, using technical information to active shares by moving from the shares that the price is predicted to decline to the increased ones. Moreover, the researcher also got the evidence that the investors in Indonesian capital market conduct their investment irrationally, investor’s analysis is getting technical and gives less attention to the fundamental factors. The decision of selling and buying which is conducted by the investors on common shares is based on the trading activity, that is actually a measurement of the scale of asymmetry information.

  20. New approach to bidding strategies of generating companies in day ahead energy market

    Energy Technology Data Exchange (ETDEWEB)

    Soleymani, S.; Ranjbar, A.M. [Sharif University of Technology, Tehran (Iran); Niroo Research Institute, Tehran (Iran); Shirani, A.R. [Niroo Research Institute, Tehran (Iran)

    2008-06-15

    In the restructured power systems, generating companies (Genco) are responsible for selling their product in the energy market. In this condition, the question is how much and for what price must each Genco generate to maximize its profit. Therefore, this paper intends to propose a rational method to answer this question. In the proposed methodology, the hourly forecasted market clearing price (FMCP) is used as a reference to model the possible and probable price strategies of Gencos. The forecasted price is the basis of the bidding strategies of each Genco, which can be achieved by solving a bi-level optimization problem using GAMS (general algebraic modeling system) language. The first level, called upper sub-problem is used to maximize the individual Genco's payoffs for obtaining the optimal offered quantity of Gencos. The second one, hereafter called the lower sub-problem uses the results of the upper sub-problem and minimizes the consumer's payment with regard to the technical and network constraints, which leads to the awarded generation of the Gencos. Similar to the other game problems, the Nash equilibrium strategies are the optimum bidding strategies of Gencos. A six bus system is employed to illustrate the application of the proposed method and to show its high precision and capabilities. (author)

  1. Use of multi-criteria decision analysis in public bidding processes: a case study

    Directory of Open Access Journals (Sweden)

    André Andrade Longaray

    2014-02-01

    Full Text Available Institutions of Higher Education in Brazil (IFES play an important role in the country’s social and scientific development. Focused mainly on teaching, research and extension activities, the IFES are backed by support foundations aimed to the management of financial, human and material resources. Characterized as public bodies, the support foundations are governed by Law no 8.666/93 in what concerns the procurement of goods and services. Therefore, the present study is aimed to develop a model to assist the managers of such foundations in the selection of suppliers to participate in bidding processes that use invitation for bids. Therefore, we conducted a case study in one of the 55 foundations that support Brazilian federal universities. The intervention tool used was the Analytic Hierarchy Process (AHP. Firstly, we established the hierarchy of criteria for problem-solving. Then, a paired comparison was made between criteria for the same level. Subsequently, the consistency analysis of comparison matrices was verified. Finally, the relative priorities of each criterion were obtained and the objective function of the model was constructed. The model was tested through the assessment of the performance of three potential suppliers of IT equipment, and the result was legitimized by decision makers who found the instrument a valid tool to aid in making decisions on supplier selection for the foundation.

  2. Application of SVG in grid electric drilling rig%SVG在网电钻机中的应用

    Institute of Scientific and Technical Information of China (English)

    林鸿元; 马保慧

    2015-01-01

    介绍了电动钻机使用网电的意义,指出钻机电控系统存在谐波和无功的来源,提出基于SVG技术的治理方案,简述SVG的工作原理,给出了设计要点和配置要点。现场应用的测试结果表明,SVG在网电钻机中的应用性价比高,经济效益显著,值得推广。%The significance of the electric drilling rigs powered by the grid is introduced. The source of producing harmonic and reactive power in the electric control systems of the drilling rigs are pointed out. The control scheme based on the SVG technology is put forward. The working principle of SVG is given. The key points for design and configuration are presented. The practical applications and the testing results show that SVG used in grid electric drilling rig has high performance to price ratio, remarkable economic benefit and is worth being promoted to be widely applied.

  3. Structural dynamics modification for derrick of deep well drilling rig based on experimental modal test and frequency sensitivity analysis

    Directory of Open Access Journals (Sweden)

    Hua Jian

    2015-09-01

    Full Text Available A statically designed derrick of deep oil well drilling rig may have poor dynamic characteristics, which can cause earlier structure failure of the drilling rig and harsh working condition. One such designed derrick is found to vibrate severely in operation while the rotation speed of rotary table is about 120 r/min with the working frequency of 2.0 Hz. To solve this problem, an experimental modal test of the derrick is conducted and the modal frequencies and vibration shapes are obtained. Through comparison of modal frequencies with that of exciting devices, it is found that the severe vibration of the drilling rig is caused by the resonance of second modal frequency (1.96 Hz and the working frequency of rotary table. Based on principles of sensitivity analysis and structural dynamics modification method, the frequency sensitivities of all nodes on the derrick are calculated and compared, and then seven nodes with high-frequency sensitivity are selected on which corresponding mass are added to vary the modal frequency. Result shows that the second modal frequency of the derrick is reduced to 1.42 Hz and is out of the normal working frequency range of rotary table, which demonstrates that the dynamic characteristics of the derrick is improved and severe vibration can be avoided.

  4. 48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

    Science.gov (United States)

    2010-10-01

    ... development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... bid and proposal (B&P) costs. (c)(2) IR&D costs are recoverable under DOE contracts to the extent they... the DOE program. The term “DOE program” encompasses the DOE total mission and its objectives....

  5. 13 CFR 126.613 - How does a price evaluation preference affect the bid of a qualified HUBZone SBC in full and open...

    Science.gov (United States)

    2010-01-01

    ... preference affect the bid of a qualified HUBZone SBC in full and open competition? 126.613 Section 126.613....613 How does a price evaluation preference affect the bid of a qualified HUBZone SBC in full and open... deem the price offered by a qualified HUBZone SBC to be lower than the price offered by another...

  6. RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.

    Science.gov (United States)

    Crill, Emma K; Furr-Rogers, Samantha R; Marriott, Ian

    2015-12-01

    A defining feature of viral central nervous system (CNS) infection is the rapid onset of severe neuroinflammation. However, the mechanisms underlying glial responses to replicative neurotropic viruses are only now becoming apparent with the discovery of a number of cytosolic sensors for viral nucleic acids. We have described the expression by murine and human glial cells of two disparate pattern recognition receptors, retinoic acid inducible gene-I (RIG-I) and DNA-dependent activator of interferon regulatory factors (DAI), receptors for viral RNA and DNA moieties, respectively. In the present study, we demonstrate the functional significance of RIG-I expression in primary murine microglia and astrocytes. Our data indicate that murine glial immune responses to a model neurotropic RNA virus, vesicular stomatitis virus, are RIG-I dependent and independent of levels of DAI expression or RNA polymerase III activity. In contrast, maximal glial inflammatory and antiviral responses to the DNA virus herpes simplex virus-1 (HSV-1) are dependent on the expression of both RIG-I and DAI, and require RNA polymerase III activity. These findings indicate that the RNA sensor, RIG-I, acts in parallel with DAI in an RNA polymerase III-dependent manner to initiate glial responses to HSV-1. We therefore suggest that RIG-I plays a significant role in the detection of both RNA and DNA pathogens by microglia and astrocytes.

  7. Rig mode option for semi-submersible drilling platform%深水半潜式钻井平台钻机选型

    Institute of Scientific and Technical Information of China (English)

    岳吉祥; 綦耀光; 肖文生; 杨磊; 陈军

    2009-01-01

    深水钻机是半潜式钻井平台关键设备,如何选择,配置深水钻机系统是设计与建造我国第六代半潜式钻井平台首要问题.从深水钻机并行和离线操作能力与配置、作业效率、可变载荷及专利影响等方面论证了深水海洋钻机模式选型问题.常规深水海洋钻机、离线钻机和双井架钻机结构特点、应用情况以及离线操作配置分析表明,离线作业配置越完整全面,作业效率提升越大.以甘特图和深水钻井实例详细分解、探讨双井架钻机作业机理,即在工序之间进行并行作业和工序内进行离线作业.对比分析3种深水海洋钻机钻单井、钻多井及完井作业效率,发现双井架钻机相对离线钻机和常规钻机可大幅度提高作业效率,但双井架钻机系统质量增加,且受专利影响,成本增加.采用增量净现值模型综合各种影响因素分析表明:双井架钻机总体优干离线钻机.图7表5参17%Mode option of deepwater rigs can affect the configuration and construction of the 6~(th) generation semi-submersible drilling platform in China. This paper assesses the mode option of deepwater rigs through analyzing different kinds of rigs off line operation ability and offline configuration, working efficiency, variable deck load (VDL) and patent influence. The analysis of design,application and offline configuration of three types of rigs-single rigs, offline rigs and dual derrick rigs, reveals the relation between offline configuration and work efficiency, that is, the more complete offline equipments are, the greater the work efficiency can be improved. The mechanism of dual derrick rigs is demonstrated by Gantt chart decomposing the whole drilling procedure of a deepwater exploration well, which is current operation and offline operation. Comparing the operation efficiency of the three-type deepwater rigs in drilling single wells, multiple wells and wells completion shows that dual derrick rigs

  8. 工程建设招投标环节职务犯罪的法律规制研究%Research on Legal Regulation of Duty-related Crime during Bid and Bidding of Engineering Construction

    Institute of Scientific and Technical Information of China (English)

    李晓鹏; 许少朋

    2011-01-01

    Recently,the field of engineering construction has became seriously corrupted in duty-related crime The amount of these subject matters is huge,and then will result in great losses for our state and the people.Specifically speaking,misfeasance and rule violation in bid and bidding stage of engineering construction are more serious.Therefore,a precise recognition on the essence and regular pattern of crimes by taking advantage of duty in bid and bidding stage of engineering construction,and effective prevention and restraint on these crimes are our predominant projects to be researched continuously.%现阶段工程建设领域业已成为职务犯罪的高发领域,涉案金额大,后果严重,给国家和人民利益造成了巨大损失,其中工程建设招投标环节违法违规问题尤为突出。正确认识工程建设招投标环节职务犯罪的特点,分析招投标职务犯罪的根源,加强工程建设招投标环节职务犯罪的法律规制研究,是预防和遏制工程建设领域职务犯罪的有效措施。

  9. BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

    DEFF Research Database (Denmark)

    Martin, Nellie Anne; Bonner, Helena; Elkjær, Maria Louise

    2016-01-01

    The BH3 interacting-domain death agonist (BID) is a pro-apoptotic protein involved in death receptor-induced and mitochondria-mediated apoptosis. Recently, it has also been suggested that BID is involved in the regulation of inflammatory responses in the central nervous system. We found that BID ...

  10. Challenges in licensing the industrial double-rig trawl fisheries in Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo-Pezzuto

    2015-07-01

    Full Text Available Bottom trawling is important in Brazilian fisheries and is currently highly multi-specific due to the overexploitation of the original targets; unselective fishing method; very large permitted fishing area and the country's high marine biodiversity. Fishing licensing in Brazil was modified in 2012 and is now based in five criteria: target species; "expected by-catch"; "incidental catches"; fishing method and area of operation. Licenses of trawling fleets exhibit, therefore, dozens of species catchable under the first three criteria. In this paper, we analyze industrial double-rig trawling fleets targeting shrimps and demersal fishes, in order to verify in what extent the new system adhere to the current fishing reality, giving new information to improve the current management regime. A total of 4,194 trips from 191 vessels were studied between 2008 and 2010 in southern Brazil. In spite of depending economically on their targets, the fleets are formally authorized to catch a high percentage of species in common (41 to 71%, and the actual landings revealed an even greater overlapping among them (71 to 82%. Vessels licensed to catch demersal fishes obtained nearly 50% of their revenue from items not included in their licenses. It was concluded that the current system encourages excessive effort concentrations over fishing resources, as they can be legally caught by most vessels irrespective of their licenses. It is suggested that licensing should move from a species-based to a spatial-based approach, by defining smaller management areas according to the respective species assemblages. Landing composition would be, therefore, mostly a biological and technological consequence, making management more reasonable and workable under a multi-specific and mega-diverse scenario.

  11. Optimal bidding strategy of battery storage in power markets considering performance based regulation and battery cycle life

    DEFF Research Database (Denmark)

    He, Guannan; Chen, Qixin; Kang, Chongqing

    2016-01-01

    Large-scale battery storage will become an essential part of the future smart grid. This paper investigates the optimal bidding strategy for battery storage in power markets. Battery storage could increase its profitability by providing fast regulation service under a performance-based regulation...

  12. 33 CFR 116.45 - Submission of bids, approval of award, guaranty of cost, and partial payments for bridges...

    Science.gov (United States)

    2010-07-01

    ... award, guaranty of cost, and partial payments for bridges eligible for funding under the Truman-Hobbs... SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.45 Submission of bids, approval of award, guaranty of cost, and partial payments for bridges eligible for funding under the...

  13. Bidding for Brains: Intellectual Property Rights and the International Migration of Knowledge Workers. NBER Working Paper No. 15486

    Science.gov (United States)

    McAusland, Carol; Kuhn, Peter J.

    2009-01-01

    We introduce international mobility of knowledge workers into a model of Nash equilibrium IPR policy choice among countries. We show that governments have incentives to use IPRs in a bidding war for global talent, resulting in Nash equilibrium IPRs that can be too high, rather than too low, from a global welfare perspective. These incentives…

  14. Evaluation of Orange and Rockland Utilities, Inc.`s competitive bidding program for demand-side resources. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Peters, J.S.; Stucky, L.; Seratt, P.; Darden-Butler, D. [Barakat and Chamberlin, Inc., Portland, OR (United States)

    1993-02-01

    The process evaluation reports on the implementation of Orange and Rockland Utilities demand-side bidding program in New York State during 1991 and 1992. The program is implemented by two energy service companies in Orange and rockland`s New York State service territory. The process evaluation methodology included interviews with utility staff (3), energy service company staff (2), and participating (6) and nonparticipating (7) utility customers. The two energy service companies had enrolled 14 customers in the program by summer 1992. One company had achieved 90% of their 2.75 MW bid and the other had achieved less than 90% of their 6.9 MW bid. Critical factors in success were determination of a reasonable bid amount for the market and marketing to the appropriate customers. Customers most interested in the program included those with limited access to capital and medium-sized firms with poor cash flows, particularly schools and hospitals. The findings also show that due to the incentive structure and associated need for substantial customer contributions, lighting measures dominate all installations. Customers, however, were interested in the potential savings and six of the nonparticipants chose to either install measures on their own or enroll in the utility`s rebate program.

  15. 76 FR 16812 - Notice of Realty Action: Modified Competitive Bid Sale of Public Land in Santa Clara County, CA

    Science.gov (United States)

    2011-03-25

    ... Notice of Realty Action: Modified Competitive Bid Sale of Public Land in Santa Clara County, CA AGENCY... approximately 9.27 acres in Santa Clara County, California, for not less than the appraised fair market value of..., more or less, in Santa Clara County. The public land was originally identified as suitable for...

  16. Influence of feasibility constrains on the bidding strategy selection in a day-ahead electricity market session

    Energy Technology Data Exchange (ETDEWEB)

    Borghetti, Alberto [Dept. of Electrical Engineering, University of Bologna, Viale risorgimento 2, 40136 Bologna (Italy); Massucco, Stefano; Silvestro, Federico [Dept. of Electrical Engineering, University of Genova, via all' Opera Pia 11a, 16145 Genova (Italy)

    2009-12-15

    Large part of liberalized electricity markets, including the Italian one, features an auction mechanism, called day-ahead energy market, which matches producers' and buyers' simple bids, consisting of energy quantity and price pairs. The match is achieved by a merit-order economic dispatch procedure independently applied for each of the hours of the following day. Power plants operation should, however, take into account several technical constraints, such as maximum and minimum production bounds, ramp constraints and minimum up and downs times, as well as no-load and startup costs. The presence of these constraints forces to adjust the scheduling provided by the market in order to obtain a feasible scheduling. The paper presents an analysis of the possibility and the limits of taking into account the power plants technical constraints in the bidding strategy selection procedure of generating companies (Gencos). The analysis is carried out by using a computer procedure based both on a simple static game-theory approach and on a cost-minimization unit-commitment algorithm. For illustrative purposes, we present the results obtained for a system with three Gencos, each owning several power plants, trying to model the bidding behaviour of every generator in the system. This approach, although complex from the computational point of view, allows an analysis of both price and quantity bidding strategies and appears to be applicable to markets having different rules and features. (author)

  17. 42 CFR 423.272 - Review and negotiation of bid and approval of plans submitted by potential Part D sponsors.

    Science.gov (United States)

    2010-10-01

    ... determinations. (1) Application of revenue requirements standard. CMS approves a bid submitted under § 423.265... revenue requirements (as used for purposes of section 1302(8)(C) of the Public Health Service Act) for... within a formulary is consistent with the model guidelines (if any) established by the United...

  18. 76 FR 18578 - Notice of Realty Action: Competitive Sealed Bid Sale of Public Lands in Clark County, NV

    Science.gov (United States)

    2011-04-04

    ... proposed sale of public land and the Competitive Sealed Bid Sale, June 1, 2011 Environmental Assessment (EA... Disposal Boundary Environmental Impact Statement (EIS), approved by Record of Decision on December 23, 2004... instrumentality, or political subdivision authorized to hold real property. United States citizenship is...

  19. Chaotic behavior of price in the power markets with pay-as-bid payment mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Bigdeli, N. [Linear Systems Control Lab., EE Department, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of)], E-mail: bigdeli@ee.sharif.edu; Afshar, K. [Electrical Machinery Lab., EE Department, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of)], E-mail: k_afshar@ee.sharif.edu

    2009-11-30

    Price forecasting in the current deregulated power markets is an important requirement for deriving proper bidding strategy and profit maximization of producers. On the other hand, the energy price in the power market experiences lots of fluctuations which may affect the accuracy of the price forecasting seriously. Seeking for predictability, in this paper, the characteristics of these fluctuations are investigated through time series analysis methods. The results of analyses are representative of the existence of a deterministic chaos in the system with a mimic predictability. Besides, it is observed that because of existing the seasonality and non-stationarity in the system dynamics, a fixed model cannot perform properly even in case of normalized input data, but the developed models should be updated regularly.

  20. Combined hydro-wind generation bids in a pool-based electricity market

    Energy Technology Data Exchange (ETDEWEB)

    Angarita, Jorge L. [INDRA S.A., Parque Empresarial LA FINCA, edif. 4 y 5 P del Club Deportivo 1, 28223-Pozuelo de Alarcon, Madrid (Spain); Usaola, Julio; Martinez-Crespo, Jorge [Department of Electrical Engineering, Universidad Carlos III de Madrid, Avda. Universidad 30, 28911-Leganes, Madrid (Spain)

    2009-07-15

    Present regulatory trends are promoting the direct participation of wind energy in electricity markets. The final result of these markets sets the production scheduling for the operation time, including a power commitment from the wind generators. However, wind resources are uncertain, and the final power delivered usually differs from the initial power committed. This imbalance produces an overcost in the system, which must be paid by those who produce it, e.g., wind generators among others. As a result, wind farm revenue decreases, but it could increase by allowing wind farms to submit their bids to the markets together with a hydro generating unit, which may easily modify its production according to the expected imbalance. This paper presents a stochastic optimization technique that maximizes the joint profit of hydro and wind generators in a pool-based electricity market, taking into account the uncertainty of wind power prediction. (author)

  1. Financing long term care under Medicaid: competitive bidding, vouchers and expenditure matching in an HMO framework.

    Science.gov (United States)

    Hogan, A J

    1983-01-01

    Within the framework of a Long Term Care--HMO, a series of innovative financing mechanisms are proposed to encourage efficiency, reduce cost increases and promote the quality of long term care. Competitive bidding is used to set prices for long term care. Based upon these competitively set prices, HMO enrollees are given long term care vouchers with which to purchase care. Cost savings, arising from choices of care less expensive than the value of the voucher, are shared with the enrollee and the case management team. Incentive payments to this team are made only after a quality of care review. A portion of the payment to the long term care provider is set aside as a quality assurance withhold. If quality of care is inadequate, the withhold is forfeit.

  2. A Sealed-Bid Two-Attribute Yardstick AuctionWithout Prior Scoring

    DEFF Research Database (Denmark)

    Leth Hougaard, Jens; Nielsen, Kurt; Papakonstantinou, Athanasios

    2016-01-01

    that following this type of equilibrium behavior often leads to winner’s curse. The simulations show that in auctions with more than 12 participants the chance of facing winner’s curse is around 95%. Truthful reporting, on the other hand, does not constitute a Nash equilibrium but it is ex post individually......We analyze a two-attribute single item procurement auction that uses yardstick competition to settle prices. The auction simplifies the procurement process by reducing the principal’s articulation of preferences to simply choosing the most preferred offer as if it was a market with posted prices...... rational. Using a simulation study we demonstrate that truthful bidding may indeed represent some kind of focal point....

  3. Neural correlates of reinforcement learning and social preferences in competitive bidding.

    Science.gov (United States)

    van den Bos, Wouter; Talwar, Arjun; McClure, Samuel M

    2013-01-30

    In competitive social environments, people often deviate from what rational choice theory prescribes, resulting in losses or suboptimal monetary gains. We investigate how competition affects learning and decision-making in a common value auction task. During the experiment, groups of five human participants were simultaneously scanned using MRI while playing the auction task. We first demonstrate that bidding is well characterized by reinforcement learning with biased reward representations dependent on social preferences. Indicative of reinforcement learning, we found that estimated trial-by-trial prediction errors correlated with activity in the striatum and ventromedial prefrontal cortex. Additionally, we found that individual differences in social preferences were related to activity in the temporal-parietal junction and anterior insula. Connectivity analyses suggest that monetary and social value signals are integrated in the ventromedial prefrontal cortex and striatum. Based on these results, we argue for a novel mechanistic account for the integration of reinforcement history and social preferences in competitive decision-making.

  4. Power Pool中发电公司的竞价策略%BIDDING STRATEGIES OF GENERATION COMPANIES IN POWER POOL

    Institute of Scientific and Technical Information of China (English)

    李灿; 龚乐年; 宋燕敏; 曹荣章; 朱为民

    2001-01-01

    This paper studies the bidding strategies of generation companiesin Power Pool. In an imperfect competition Power Pool, some generation companies (GenComs) may have market power. A GenCom can bid as a price acceptor or as a price changer. A price acceptor will bid according to its marginal cost curve, but the minimum bid price must be decided by dynamic programming based on price forecasting. A price changer will bid according to the strategy of restricting output and forcing up price. The Power Pool will be inefficient when market power of GenComs are strong.%研究了电力联营体(PowerPool)中发电公司的报价策略。在非完全竞争的PowerPool中,发电公司可以作为一个价格接受者,也可利用其市场势力操纵市场价格。发电公司作为价格接受者时将基于边际成本曲线报价,但其最低报价必须根据市场行情而变化;具有市场势力的发电公司可以采取限制产量、抬高电价的策略。PowerPool中市场势力的存在不利于资源的优化配置和利用。

  5. Struktur Nalar Arab-Islam menurut ‘Âbid Al-Jâbirî

    Directory of Open Access Journals (Sweden)

    M. Faishol

    2016-03-01

    Full Text Available The project of ‘Âbid Al-Jâbirî’s thoughts has become epistemological critic to traditional frame of Islam-Arab knowledge through analyzing socio-political background on the logic of Arab formulation. According to Al-Jâbirî, the logic of Arabic thought could be devised into three methods: bayâni, ‘irfâni and burhâni. Therefore, the structure of Islam-Arab culture has occurred based on: (1 authoritative texts—because the logic of Arab is exceedingly based on religious texts, (2 authoritative salaf, that is, focused on ‘ulama’s considerations, and (3 authoritative permissivism along with anti-causality (sult}ah at-tajwîz al-lâsababiyyah. Hence, Arabic culture becomes unproductive, poor of concept and theory. As a solution, Al-Jâbirî invites to contextualize the spirit of critic such as rational-empiricism of Ibn H{azm and al-Shât}ibî on fiqh, Ibn Rushd on philosophy, Ibn Khaldûn on sociology, etc. This article will probe specifically about ‘Âbid Al-Jâbirî’s reform thought. Al-Jâbirî’s thinking distinctiveness lies in the epistemological critique conducted on the science that develops in the Arab-Islamic civilization. The epistemological critique becomes a realm of science that not much attention, especially by Muslim thinkers. Al-Jâbirî’s epistemological critique offers to the Muslim world an attempt to reconstruct the building of reason-epistemic knowledge to keep pace and change its Islamic world towards the progress of civilization.

  6. Discussion on base bid price controlling strategies in engineering tendering%谈工程招标中的标底控制策略

    Institute of Scientific and Technical Information of China (English)

    李学兵

    2012-01-01

    On the basis of introducing the definition and functions of base bid price, the paper comprehensively explores base bid price control- ling strategies from aspects of determining engineering project, compiling basic principles of base bid price, common compiling base bid price methods, improving rationality of base bid price, and common methods and points of determining base bid price and so on, with a view to guar- antee smooth operation of bidding and tendering work.%在介绍了标底的定义和分析了标底作用的基础上,从工程项目确定和编制标底的基本原则、编制工程项目标底的常用方法、提高工程项目标底合理性、确定工程项目标底的常用方法和要点等几个方面,全面探讨了工程招标中的标底控制策略,以期保障招投标工作的顺利进行。

  7. Penalty model for delay of bidding section construction period in South-to-North Water Diversion Eastern Route Project from perspective of programs

    Directory of Open Access Journals (Sweden)

    Jing-chun FENG

    2012-09-01

    Full Text Available According to the multi-project and program management theory, this paper analyzes the program generation principle and establishes a program based on progress goals. On the basis of the present situation of calculation of penalty for delay of the bidding section construction period with the critical path method, we studied the effects of contractor-induced delay of the bidding section construction period in detail, including the effects on the construction period of the bidding section itself, the earliest start times of the next bidding section and other subsequent bidding sections, and the construction period of the program, and then constructed a penalty model for delay of the bidding section construction period from the perspective of programs. Using the penalty model, we conducted a practical analysis of penalty for delay of the construction period of the Baoying station program in the South-to-North Water Diversion Project. The model can help determine the amount of penalty for delay of the construction period in bidding sections scientifically and reasonably.

  8. Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance

    Science.gov (United States)

    Erler, Janine T.; Cawthorne, Christopher J.; Williams, Kaye J.; Koritzinsky, Marianne; Wouters, Bradley G.; Wilson, Clare; Miller, Crispin; Demonacos, Costas; Stratford, Ian J.; Dive, Caroline

    2004-01-01

    Solid tumors with disorganized, insufficient blood supply contain hypoxic cells that are resistant to radiotherapy and chemotherapy. Drug resistance, an obstacle to curative treatment of solid tumors, can occur via suppression of apoptosis, a process controlled by pro- and antiapoptotic members of the Bcl-2 protein family. Oxygen deprivation of human colon cancer cells in vitro provoked decreased mRNA and protein levels of proapoptotic Bid and Bad. Hypoxia-inducible factor 1 (HIF-1) was dispensable for the down-regulation of Bad but required for that of Bid, consistent with the binding of HIF-1α to a hypoxia-responsive element (positions −8484 to −8475) in the bid promoter. Oxygen deprivation resulted in proteosome-independent decreased expression of Bax in vitro, consistent with a reduction in global translation efficiency. The physiological relevance of Bid and Bax down-regulation was confirmed in tumors in vivo. Oxygen deprivation resulted in decreased drug-induced apoptosis and clonogenic resistance to agents with different mechanisms of action. The contribution of Bid and/or Bax down-regulation to drug responsiveness was demonstrated by the relative resistance of normoxic cells that had no or reduced expression of Bid and/or Bax and by the finding that forced expression of Bid in hypoxic cells resulted in increased sensitivity to the topoisomerase II inhibitor etoposide. PMID:15024076

  9. Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.

    Science.gov (United States)

    Lemos de Matos, Ana; McFadden, Grant; Esteves, Pedro J

    2014-01-01

    One of the most severe European rabbit (Oryctolagus cuniculus) pathogens is myxoma virus (MYXV), a rabbit-specific leporipoxvirus that causes the highly lethal disease myxomatosis. Other leporid genera, Sylvilagus and Lepus, encompass species with variable susceptibilities to MYXV, but these do not develop the lethal form of the disease. The protective role of the retinoic acid-inducible gene-I (RIG-I/DDX58) in sensing MYXV in nonpermissive human myeloid cells prompted the study of the RIG-I-like receptor (RLR) family evolution in the three leporid genera. This viral-sensor family also includes the melanoma differentiation-associated factor 5 (MDA5/IFIH1), and the laboratory of genetics and physiology 2 (LGP2/DHX58). Considering specifically the MYXV susceptible host (European rabbit) and one of the virus natural long-term hosts (Sylvilagus bachmani, brush rabbit), the amino acid differences of positively selected sites in RIG-I between the two species were located in the protein region responsible for viral RNA recognition and binding, the repressor domain. Such differences might play a determinant role in how MYXV is sensed. When looking for episodic selection on MDA5 and LGP2 of the eastern cottontail (Sylvilagus floridanus), we also uncovered evidence of selective pressures that might be exerted by a species-specific leporipoxvirus, the Shope fibroma virus. Finally, a putative alternative splicing case was identified in Oryctolagus and Lepus MDA5 isoforms, corresponding to the deletion of one specific exon. This study provided the first insights into the evolution of the leporid RLR gene family that helps illuminate the origins of the species-specific innate responses to pathogens and more specifically to MYXV.

  10. Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I.

    Directory of Open Access Journals (Sweden)

    Stéphane Biacchesi

    Full Text Available Viral infections are detected in most cases by the host innate immune system through pattern-recognition receptors (PRR, the sensors for pathogen-associated molecular patterns (PAMPs, which induce the production of cytokines, such as type I interferons (IFN. Recent identification in mammalian and teleost fish of cytoplasmic viral RNA sensors, RIG-I-like receptors (RLRs, and their mitochondrial adaptor: the mitochondrial antiviral signaling (MAVS protein, also called IPS-1, highlight their important role in the induction of IFN at the early stage of a virus infection. More recently, an endoplasmic reticulum (ER adaptor: the stimulator of interferon genes (STING protein, also called MITA, ERIS and MPYS, has been shown to play a pivotal role in response to both non-self-cytosolic RNA and dsDNA. In this study, we cloned STING cDNAs from zebrafish and showed that it was an ortholog to mammalian STING. We demonstrated that overexpression of this ER protein in fish cells led to a constitutive induction of IFN and interferon-stimulated genes (ISGs. STING-overexpressing cells were almost fully protected against RNA virus infection with a strong inhibition of both DNA and RNA virus replication. In addition, we found that together with MAVS, STING was an important player in the RIG-I IFN-inducing pathway. This report provides the demonstration that teleost fish possess a functional RLR pathway in which MAVS and STING are downstream signaling molecules of RIG-I. The Sequences presented in this article have been submitted to GenBank under accession numbers: Zebrafish STING (HE856619; EPC STING (HE856620; EPC IRF3 (HE856621; EPC IFN promoter (HE856618.

  11. Continuous structural monitoring of oil rig sub-sea structures for flooded member detection using underwater ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Mijarez, R. [Gerencia de Control e Instrumentacion, Cuernavaca, Morelos (Mexico). Inst. de Investigaciones Electricas; Gaydecki, P. [Manchester Univ. (United Kingdom). School of Electrical and Electronic Engineering; Burdekin, M. [Fatigue Monitoring Bureau, Macclesfield (United Kingdom)

    2006-07-01

    An underwater ultrasound system for detecting flooding in the hollow sub-sea structures of offshore steel oil-rigs is presented. A sensor, attached to a subsea structure and powered by seawater, transmits underwater ultrasound chirpencoded signals to a real-time digital signal processing monitoring system at surface level. Experiments performed using a jointed steel pipe structure 1 ton in weight, with dimensions of 7 m x 0.5 m x 16 mm, completely immersed in seawater showed excellent performance using a central excitation frequency of 38 kHz, over distances of 100 m. (orig.)

  12. Desenvolvimento de rigging e movimento para cães em Animação 3D

    OpenAIRE

    Pinheiro, Ricardo Miranda

    2015-01-01

    Esta dissertação tem como objetivo principal abordar, no âmbito do cinema de animação 3D, a elaboração de rigging e movimento para personagens caninos. Desta forma, o objeto de estudo foca-se em todas as etapas de desenvolvimento de personagens caninas, tendo como ponto de partida o estudo da anatomia óssea e muscular canina. Depois de analisada a anatomia, será necessário transferir esses conhecimentos para o ambiente 3D. O estudo da anatomia muscular irá permitir-nos iniciar o processo d...

  13. Materials and boiler rig testing to support chemical cleaning of once-through AGR boilers

    Energy Technology Data Exchange (ETDEWEB)

    Tice, D.R.; Platts, N.; Raffel, A.S. [Serco Assurance (United Kingdom); Rudge, A. [British Energy Generation Ltd. (United Kingdom)

    2002-07-01

    reagent being chosen. This paper describes the results of the latter two activities: additional materials testing necessary to support a full scale plant clean and the trial clean on a model boiler rig replicating a single boiler tube together with the pre- and post-clean thermohydraulic behaviour. (authors)

  14. STRUCTURE OF CONSORTIUM DESTRUCTIVE COMPONENTS IN THE INDUSTRIAL AREA OF KRIVYI RIG BASIN

    Directory of Open Access Journals (Sweden)

    Kachinskaya V.V.

    2014-08-01

    Full Text Available Тhe structural organization and a biological variety of ground mesofauna on consortium level of the organization of ecosystems are considered. The analysis of indicators of the structural organization and a biodiversity of ground mesofauna in consortium Ulmus and Populus in the conditions of territories of industrial mining – metallurgical complex of Krivyi Rig Basin is carried out. It is established that taxonomical structure of ground mesofauna is characterized by insignificant number and quantity of taxonomical groups. Prevalence in morfo-ecological structure of hortobiontes and herpetobiontes testifies about faunae considerable attachment to consortium determinants and influences of a steppe climate on its structure. Prevalence of phytophages and polyphages in trophic structure is caused by combination of determinants specificity of consortium and zone source of fauna formations. The structural organization of ground mesofauna in consortium Ulmus and Populus in the conditions of industrial sites is characterized simplified taxonomical structure with a low biodiversity at all levels. It was suggested that structural and functional organization of destructive components of the block consortium of Ulmus and Populus in the conditions of industrial sites are simplified and determined by biogeochemical patterns of pedogenic and leaf litter layer of consortium and type of anthropogenic impact. Management and sustainable use of consortium under technogenic pressure should be based on the effects of extreme and critical components in the evolution of consortium. These critical points are the type of leading man-made factors and pedogenic and leaf litter biogeochemical conditions of consortium determinants, which results in inhibition of development and simplification of the structural and functional organization of destructive components of the block. The elaboration of measures to restore and maintain that structural and functional organization

  15. STRUCTURE OF CONSORTIUM DESTRUCTIVE COMPONENTS IN THE INDUSTRIAL AREA OF KRIVYI RIG BASIN

    Directory of Open Access Journals (Sweden)

    V. V. Kachinskaya

    2014-07-01

    Full Text Available Тhe structural organization and a biological variety of ground mesofauna on consortium level of the organization of ecosystems are considered. The analysis of indicators of the structural organization and a biodiversity of ground mesofauna in consortium Ulmus and Populus in the conditions of territories of industrial mining – metallurgical complex of Krivyi Rig Basin is carried out. It is established that taxonomical structure of ground mesofauna is characterized by insignificant number and quantity of taxonomical groups. Prevalence in morfo-ecological structure of hortobiontes and herpetobiontes testifies about faunae considerable attachment to consortium determinants and influences of a steppe climate on its structure. Prevalence of phytophages and polyphages in trophic structure is caused by combination of determinants specificity of consortium and zone source of fauna formations. The structural organization of ground mesofauna in consortium Ulmus and Populus in the conditions of industrial sites is characterized simplified taxonomical structure with a low biodiversity at all levels. It was suggested that structural and functional organization of destructive components of the block consortium of Ulmus and Populus in the conditions of industrial sites are simplified and determined by biogeochemical patterns of pedogenic and leaf litter layer of consortium and type of anthropogenic impact. Management and sustainable use of consortium under technogenic pressure should be based on the effects of extreme and critical components in the evolution of consortium. These critical points are the type of leading man-made factors and pedogenic and leaf litter biogeochemical conditions of consortium determinants, which results in inhibition of development and simplification of the structural and functional organization of destructive components of the block. The elaboration of measures to restore and maintain that structural and functional organization

  16. Wear mechanism of disc-brake block material for new type of drilling rig

    Institute of Scientific and Technical Information of China (English)

    Xinhua WANG; Simin WANG; Siwei ZHANG; Deguo WANG

    2008-01-01

    To improve friction and wear performance and service life of the disc-brake pair material of a drilling rig, a new type of asbestos-free frictional material with better performance for disc-brake blocks is developed, and its wear mechanism is investigated by friction and wear experiments. Topography and ele-mentary components of the brake block's wear surface are analyzed by employing SEM and EDAX patterns, revealing its tribological behaviour and wear mechan-ism. When the frictional temperature is lower, the surface film of the brake block is thinner, dense, smooth with plasticity, and divided into the mixture area, Fe-abundant area, carbon-abundant area and spalling area. The mixture area consists of various constituents of frictional pairs without ploughing and rolling trace. The Fe-abundant area mainly consists of iron and other constituents. The carbon-abundant area is the zone where graphite and organic fibre are comparatively gathered, while the spalling area is the zone where the surface film is spalled and its surface is rough and uneven, with a loose and denuded state. During the period of high frictional temperature, the frictional surface is also divided into the mixture area, Fe-abundant area and spalling area. In this case, the mixture area consists of abrasive dust from friction pairs, and the surface film is distributed with crumby hard granules, exiguous oxide, carbide granules and sheared slender fibre. The Fe-abundant area is mostly an oxide layer of iron with a flaky distribution. Fracture and spalling traces as well as an overlapping structure of multilayer surface films can be easily found on the surface film. The components of the spalling area are basically the same as that of the matrix. At the beginning of wear, the hard peaks from the friction surface of the disc-brake plough on the surface of the brake block. With increasing frictional temperature, the friction surface begins to soften and expand, and oxidized wear occurs at the same

  17. Water Well Drilling Rig Status Quo and Development Trend in China%国内水井钻机的现状及发展趋势

    Institute of Scientific and Technical Information of China (English)

    高占听

    2014-01-01

    The paper has introduced development history of water well drilling rigs briefly and general situation,technical features at present. Through performance comparison of home and abroad,analyzed technological gap of rotary table water well rigs between Chi-na and abroad. Combined with fully hydraulic top drive water well rig technical characteristics,have advised to develop multifunction-al fully hydraulic top drive water well rig can greatly narrow the gap,thus the development orientation of water well rig in China.%简要介绍了水文水井钻机的发展历史,以及我国现阶段水井钻机的概况及技术特点,通过与国外钻机的性能对比,分析了我国转盘式水井钻机在技术上与国外的差距,结合全液压动力头水井钻机的技术特点,提出了研制多功能全液压动力头水井钻机,可以大大缩短我国与国外在技术上的差距,这也是当前各国水井钻机的发展方向。

  18. BID-F1 and BID-F2 domains of Bartonella henselae effector protein BepF trigger together with BepC the formation of invasome structures.

    Science.gov (United States)

    Truttmann, Matthias C; Guye, Patrick; Dehio, Christoph

    2011-01-01

    The gram-negative, zoonotic pathogen Bartonella henselae (Bhe) translocates seven distinct Bartonella effector proteins (Beps) via the VirB/VirD4 type IV secretion system (T4SS) into human cells, thereby interfering with host cell signaling [1], [2]. In particular, the effector protein BepG alone or the combination of effector proteins BepC and BepF trigger massive F-actin rearrangements that lead to the establishment of invasome structures eventually resulting in the internalization of entire Bhe aggregates [2], [3]. In this report, we investigate the molecular function of the effector protein BepF in the eukaryotic host cell. We show that the N-terminal [E/T]PLYAT tyrosine phosphorylation motifs of BepF get phosphorylated upon translocation but do not contribute to invasome-mediated Bhe uptake. In contrast, we found that two of the three BID domains of BepF are capable to trigger invasome formation together with BepC, while a mutation of the WxxxE motif of the BID-F1 domain inhibited its ability to contribute to the formation of invasome structures. Next, we show that BepF function during invasome formation can be replaced by the over-expression of constitutive-active Rho GTPases Rac1 or Cdc42. Finally we demonstrate that BID-F1 and BID-F2 domains promote the formation of filopodia-like extensions in NIH 3T3 and HeLa cells as well as membrane protrusions in HeLa cells, suggesting a role for BepF in Rac1 and Cdc42 activation during the process of invasome formation.

  19. BID-F1 and BID-F2 domains of Bartonella henselae effector protein BepF trigger together with BepC the formation of invasome structures.

    Directory of Open Access Journals (Sweden)

    Matthias C Truttmann

    Full Text Available The gram-negative, zoonotic pathogen Bartonella henselae (Bhe translocates seven distinct Bartonella effector proteins (Beps via the VirB/VirD4 type IV secretion system (T4SS into human cells, thereby interfering with host cell signaling [1], [2]. In particular, the effector protein BepG alone or the combination of effector proteins BepC and BepF trigger massive F-actin rearrangements that lead to the establishment of invasome structures eventually resulting in the internalization of entire Bhe aggregates [2], [3]. In this report, we investigate the molecular function of the effector protein BepF in the eukaryotic host cell. We show that the N-terminal [E/T]PLYAT tyrosine phosphorylation motifs of BepF get phosphorylated upon translocation but do not contribute to invasome-mediated Bhe uptake. In contrast, we found that two of the three BID domains of BepF are capable to trigger invasome formation together with BepC, while a mutation of the WxxxE motif of the BID-F1 domain inhibited its ability to contribute to the formation of invasome structures. Next, we show that BepF function during invasome formation can be replaced by the over-expression of constitutive-active Rho GTPases Rac1 or Cdc42. Finally we demonstrate that BID-F1 and BID-F2 domains promote the formation of filopodia-like extensions in NIH 3T3 and HeLa cells as well as membrane protrusions in HeLa cells, suggesting a role for BepF in Rac1 and Cdc42 activation during the process of invasome formation.

  20. Advances in developing the air-lift drilling technology. Concept of a portal drilling rig - trial of a steerable shaft drilling bit

    Energy Technology Data Exchange (ETDEWEB)

    Weber, W.

    1988-12-01

    The Federal Minister of Research and Technology is supporting a project of Wirth GmbH to develop a new drilling rig suitable for drilling deep shafts from the surface through ground of almost any condition, from unstable formations to solid rock. The development of such drilling rig is based on the blind drilling method with air-assisted reverse circulation. - Various concepts of drilling rigs have been developed in accordance with different planning stages of a combined RD-project. Based on the experience of an extensive R and D program a steerable vertical drilling bit has been developed by which deviations from the vertical can be positively corrected. The prototype of this steerable bit with a diameter of 2.1 m has been tested successfully while drilling a well with a depth of more than 200 m in an open pit coal mine.

  1. Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome

    Science.gov (United States)

    Cao, Zhongying; Zhou, Yaqin; Zhu, Shengli; Feng, Jian; Chen, Xueyuan; Liu, Shi; Peng, Nanfang; Yang, Xiaodan; Xu, Gang; Zhu, Ying

    2016-01-01

    When retinoic acid-inducible gene 1 protein (RIG-I)-like receptors sense viral dsRNA in the cytosol, RIG-I and melanoma differentiation-associated gene 5 (MDA5) are recruited to the mitochondria to interact with mitochondrial antiviral signaling protein (MAVS) and initiate antiviral immune responses. In this study, we demonstrate that the biotin-containing enzyme pyruvate carboxylase (PC) plays an essential role in the virus-triggered activation of nuclear factor kappa B (NF-κB) signaling mediated by MAVS. PC contributes to the enhanced production of type I interferons (IFNs) and pro-inflammatory cytokines, and PC knockdown inhibits the virus-triggered innate immune response. In addition, PC shows extensive antiviral activity against RNA viruses, including influenza A virus (IAV), human enterovirus 71 (EV71), and vesicular stomatitis virus (VSV). Furthermore, PC mediates antiviral action by targeting the MAVS signalosome and induces IFNs and pro-inflammatory cytokines by promoting phosphorylation of NF-κB inhibitor-α (IκBα) and the IκB kinase (IKK) complex, as well as NF-κB nuclear translocation, which leads to activation of interferon-stimulated genes (ISGs), including double-stranded RNA-dependent protein kinase (PKR) and myxovirus resistance protein 1 (Mx1). Our findings suggest that PC is an important player in host antiviral signaling. PMID:26906558

  2. Investigation of the 4-Quadrant behaviour of a mixed flow diffuser pump with CFD-methods and test rig evaluation

    Science.gov (United States)

    Höller, S.; Benigni, H.; Jaberg, H.

    2016-11-01

    The complete pump characteristics including its 4-quadrant behaviour are of essential interest for off-design operations such as a pump trip. At this exceptional load case the pump enters the dissipation mode and moves further into the turbine mode while the direction of rotation and the flow direction will change. The time-consuming and expensive experimental investigation of the 4-quadrant behaviour requires a specific test rig, allowing the flow direction as well as the rotational direction of the investigated pump to be reverted. By measuring the pump performance (head and efficiency) at variable positive and negative discharge and rotation the complete pump characteristics are evaluated. Nowadays CFD- analysis allows for the reliable prediction of the hydraulic performance of a pump near the design point. However, abnormal operating conditions lead to complex and unsteady flow phenomena inside the pump. Besides steady-state calculations in the normal operating conditions quite comprehensive transient CFD-investigations are required to simulate the whole pump characteristics accurately. The present study focuses on the comparison of the results obtained on the test rig and by numerical methods and shows a remarkably good agreement between them. It can be shown that it is possible to reliably simulate the 4-quadrant behaviour of a mixed flow diffuser pump based on CFD-methods. Furthermore an exemplary waterhammer calculation shows the successful application of the numerically calculated 4- quadrant behaviour.

  3. Experimental analysis of control loops with different delay times in the supply air system of a radiator test rig

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yongpan; Zhao, Tianyi [School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Zhang, Jili; Lu, Zhen [School of Civil and Hydraulic Engineering, Dalian University of Technology, Dalian 116024 (China); Liu, Hui [Beijing Siemens Cerberus Electronics Ltd, Beijing 100085 (China)

    2011-01-15

    The test rig of low-temperature hot-water radiator is a typical multi-input multi-output (MIMO) thermal system with large time delay. Aiming at the control of the supply air temperature and the temperature of the environmental chamber in the test rig, the paper carries out the fuzzy control experiments and PI control experiments based on adjusting the electric heater in the supply air system, in which there are two control loops with various delay time. The experiments researched two types of fuzzy control methods which are the basic fuzzy control (BFC), and the self-organizing rules fuzzy control (SORFC) with zero initial control rules. For the control loop of supply air temperature with short delay time, PI control performs better with fast convergence speed and small overshoot than the BFC and the SORFC. The convergence speed of the BFC method is lower than other two control methods. For the control loop of chamber temperature with long delay time, the SORFC has a satisfied control performance with less overshoot and stable error than the BFC and PI control. (author)

  4. ANALISA PERHITUNGAN KEBUTUHAN PENERANGAN PADA BANGUNAN RIG RAISIS (OFFSHORE BERDASARKAN CLASS ABS DAN BKI BERBASIS VISUAL BASIC

    Directory of Open Access Journals (Sweden)

    Feri Diana

    2014-02-01

    Full Text Available Rig RAISIS adalah salah satu pengeboran milik P.T Apexindo Pratama Duta Tbk (APEX yang disewa oleh P.T TOTAL untuk memperpanjang kontraknya selama beberapa tahun. Rig RAISIS ini adalah bangunan offshore yang sudah lama berdiri namun perlu direnovasi. Untuk merenovasi diperlukan konsultan bangunan maritim yang salah satunya ditangani oleh P.T Terafulk Megantara Design. Dalam hal ini mereka masih menggunakan perhitungan secara manual. Maka untuk merencanakan penerangan dengan mudah dibuatlah program perhitungan lampu menggunakan program Visual Basic. Program ini dirancang menggunakan beberapa menu perhitungan berdasarkan dua formula, yaitu formula yang sudah lama diterapkan di PT Terafulk Megantara Design dan formula secara teoritis. Langkah menggunakan program ini adalah dengan memasukkan dimensi ruangan, iluminasi, dan luminasi maka akan muncul hasil luas ruangan dan jumlah lampu berdasarkan tipe lampu yang sudah dipilih. Program ini bisa digunakan untuk menghitung jumlah lampu berdasarkan 2 class yaitu ABS dan BKI. Berdasarkan 2 class yang sudah dihitung maka class ABS mempunyai jumlah lampu lebih banyak dibandingkan ruangan yang menggunakan class BKI. Program ini juga lebih cepat digunakan oleh perancang dengan waktu 45 menit dibandingkan menggunakan perhitungan manual yang memakan waktu 1,5 jam saat menghitung Deck Level 31.

  5. A unique laboratory test rig reduces the need for offshore tests to combat calcium naphthenate deposition in oilfield process equipment.

    Energy Technology Data Exchange (ETDEWEB)

    Mediaas, Heidi; Grande, Knut; Hustad, Britt-Marie; Hoevik, Kim Reidar; Kummernes, Hege; Nergaard, Bjoern; Vindstad, Jens Emil

    2006-03-15

    Producing and refining high-TAN crude oils introduces a number of challenges, among which calcium naphthenate deposition in process facilities is the most serious production issue. Until recently, the only option for studying chemicals and process parameters in order to prevent naphthenate deposition has been field tests. Statoil has now developed a small scale pilot plant where these experiments can be performed in the laboratory at Statoil's Research and Technology Center in Trondheim, Norway. The results from the pilot plant are in full agreement with the extensive naphthenate experience obtained from almost 9 years operation of the Heidrun oilfield. The design and operational procedures for this test facility are based on the recent discovery by Statoil and ConocoPhillips of the ARN acid. The ARN acid is a prerequisite for calcium naphthenate deposition. The new continuous flow pilot plant, the Naphthenate Rig, is used to develop new environmental friendly naphthenate inhibitors and to optimize process operating conditions. Since it operates on real crudes the need for field tests in qualifying new naphthenate inhibitors is reduced. To the best of our knowledge, the rig is the first of its kind in the world. (Author)

  6. Notification: Hotline Complaint – Region 7 Compliance with Bid, Payment, and Performance Bond Requirements Outlined in Federal Acquisition Regulation (FAR) Part 28

    Science.gov (United States)

    June 1, 2012. In response to an anonymous hotline complaint, the OIG plans to conduct a review of Region 7’s compliance with bid, payment, and performance bond requirements outlined in Federal Acquisition Regulation (FAR) Part 28.

  7. Common problems and their countermeasures of the tendering and bidding%招投标常见问题及对策

    Institute of Scientific and Technical Information of China (English)

    刘志飞

    2016-01-01

    结合实践工作经验,从组织机构、招投标流程、招标文件编制、定标原则、资格预审等方面,分析了工程建设招投标工作中常见的问题,并提出了具体的解决措施,从而促进招投标市场的良性发展。%Combining with the practical work experience,from the organization,bidding process,bidding document compilation,scale principle, prequalification and other aspects,this paper analyzed the common problems in engineering construction bidding work,and put forward some spe-cific solutions,so as to promote the benign development of bidding market.

  8. The reflection on consummating the bid evaluation expert bank of library book-purchase bidding%关于完善高校图书采购招标评标专家库的思考

    Institute of Scientific and Technical Information of China (English)

    钟萍

    2012-01-01

      This paper expounds the characteristic of book-purchase and the importance of the public bidding of book-purchasing, emphasizes, as the crux of quality control, the expert’s principal role during the process of the public bidding. Aiming at the analysis of the existing problems turning up in the practical work,the author discusses how to chose the experts in a scientific, standard way and how to consummate the construction of the bid evaluation expert bank so as to guarantee the work of book-purchasing to develop towards a healthy, standard, order way.%  论述了图书采购招标的重要意义及图书采购的特点,强调了作为质量控制关键的评标专家在评标活动中的主体作用。结合近年来评标专家在评标工作中出现的问题,就如何科学化、规范化地建设评标专家队伍,完善高校评标专家库建设进行了探讨,从而保证图书采购工作朝着健康、规范、有序的方向发展

  9. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Bao-guang [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Department of Gastrointestinal Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong (China); Liu, Li-ping [Department of Hepatobiliary and Pancreas Department of Hepatobiliary Surgery, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China); Chen, George G., E-mail: gchen@cuhk.edu.hk [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Ye, Cai Guo; Leung, Kevin K.C.; Ho, Rocky L.K.; Lin, Marie C.; Lai, Paul B.S. [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong)

    2014-06-10

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo.

  10. Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.

    Directory of Open Access Journals (Sweden)

    Matthias Habjan

    Full Text Available Innate immunity is critically dependent on the rapid production of interferon in response to intruding viruses. The intracellular pathogen recognition receptors RIG-I and MDA5 are essential for interferon induction by viral RNAs containing 5' triphosphates or double-stranded structures, respectively. Viruses with a negative-stranded RNA genome are an important group of pathogens causing emerging and re-emerging diseases. We investigated the ability of genomic RNAs from substantial representatives of this virus group to induce interferon via RIG-I or MDA5. RNAs isolated from particles of Ebola virus, Nipah virus, Lassa virus, and Rift Valley fever virus strongly activated the interferon-beta promoter. Knockdown experiments demonstrated that interferon induction depended on RIG-I, but not MDA5, and phosphatase treatment revealed a requirement for the RNA 5' triphosphate group. In contrast, genomic RNAs of Hantaan virus, Crimean-Congo hemorrhagic fever virus and Borna disease virus did not trigger interferon induction. Sensitivity of these RNAs to a 5' monophosphate-specific exonuclease indicates that the RIG-I-activating 5' triphosphate group was removed post-transcriptionally by a viral function. Consequently, RIG-I is unable to bind the RNAs of Hantaan virus, Crimean-Congo hemorrhagic fever virus and Borna disease virus. These results establish RIG-I as a major intracellular recognition receptor for the genome of most negative-strand RNA viruses and define the cleavage of triphosphates at the RNA 5' end as a strategy of viruses to evade the innate immune response.

  11. Effect of 25-hydroxyvitamin D3 on rotavirus replication and gene expressions of RIG-I signalling molecule in porcine rotavirus-infected IPEC-J2 cells.

    Science.gov (United States)

    Zhao, Ye; Yu, Bing; Mao, Xiangbing; He, Jun; Huang, Zhiqing; Zheng, Ping; Yu, Jie; Han, Guoquan; Liang, Xiaofang; Chen, Daiwen

    2015-01-01

    The study evaluated whether a 25-hydroxyvitamin D3 (25D3) supplementation decreases the replication of rotavirus by the retinoic acid-inducible gene I (RIG-I) signalling pathway in a porcine small intestinal epithelial cell line (IPEC-J2). The results show that IPEC-J2 cells express high baseline levels of 1α-hydroxylase (CYP27B1), which converts inactive 25D3 to the active 1,25-dihydroxyvitamin D3 (1,25D3). Porcine rotavirus (PRV) infection alone resulted in a significant increase in CYP27B1 mRNA, which augmented the production of active vitamin D. Physiological concentrations of 25D3 were found to decrease PRV replication in IPEC-J2 cells. RIG-I plays an important role in the recognition of double-stranded RNA virus by host cells. Upon recognition, RIG-I triggers a series of signalling molecules such as interferon-β (IFN-β) promoter stimulator 1 (IPS-1) leading to the expression of type I interferons (IFN-β). Active 25D3 that was generated by PRV-infected IPEC-J2 cells led to an increased expression of toll-like receptors 3 (TLR3), RIG-I, IPS-1, IFN-β and IFN-stimulated genes 15 (ISG15) with important innate immune functions. Inhibiting CYP27B1 also failed to increase RIG-I, IPS-1, IFN-β and ISG15 mRNA expression. These observations suggest that 25D3 can directly inhibit PRV in IPEC-J2 cells, which requires this active form of vitamin D. The anti-rotavirus effect of 25D3 is mediated at least in part by RIG-I signalling pathways in IPEC-J2 cells.

  12. 推行合理低价法的意义%Meaning of promoting reasonable low bidding price

    Institute of Scientific and Technical Information of China (English)

    董卫亭

    2011-01-01

    从现阶段合理低价法的现状入手,总结了合理低价法在实际操作中存在的问题,重点论述了实施合理低价法的必要性及意义,并给出了实施合理低价法必须坚持的原则,从而最终实现最低价中标。%Starting from the status of reasonable low price, the essay summarizes the problems existing in actual low price bidding, mainly discusses the necessity and meaning of implementing reasonable low price, and shows principles which should be held in implementing reasonable low price, so as to realize the lowest bidding price.

  13. Seguridad Vial - BID: Una estrategia para la región de América Latina y el Caribe

    OpenAIRE

    Néstor Roa

    2012-01-01

    Presentación del Jefe de la División de Transporte del Banco, Nestor Roa, durante el principal evento regional de Seguridad Vial de América Latina y el Caribe, CISEV III que se realizó en Bogotá DC entre el 12 y el 14 de junio de 2012. El documento muestra el trabajo de la estrategia de Seguridad Vial del BID.

  14. "Fan-Tip-Drive" High-Power-Density, Permanent Magnet Electric Motor and Test Rig Designed for a Nonpolluting Aircraft Propulsion Program

    Science.gov (United States)

    Brown, Gerald V.; Kascak, Albert F.

    2004-01-01

    A scaled blade-tip-drive test rig was designed at the NASA Glenn Research Center. The rig is a scaled version of a direct-current brushless motor that would be located in the shroud of a thrust fan. This geometry is very attractive since the allowable speed of the armature is approximately the speed of the blade tips (Mach 1 or 1100 ft/s). The magnetic pressure generated in the motor acts over a large area and, thus, produces a large force or torque. This large force multiplied by the large velocity results in a high-power-density motor.

  15. A New Design of the Universal Test Rig to Measure the Wear Characterizations of Polymer Acetal Gears (Spur, Helical, Bevel, and Worm)

    OpenAIRE

    Samy Yousef; Osman, T. A.; Khattab, M.; Bahr, Ahmed A.; Ahmed M. Youssef

    2015-01-01

    This work aims to study the wear characterization of common types of acetal polymer gears (spur, helical, bevel, and worm) using a new TS universal test rig, in order to obtain reliable results and as a reference when compared with acetal nanocomposite gears later. The TS universal test rig consists of three different units that are connected by a main driver shaft and a pair of constantly meshing metal spur gears, which transfer power to the bevel and worm test units. The first unit is used ...

  16. Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response.

    Science.gov (United States)

    Reynard, Stéphanie; Russier, Marion; Fizet, Alexandra; Carnec, Xavier; Baize, Sylvain

    2014-12-01

    Lassa virus (LASV), which causes a viral hemorrhagic fever, inhibits the innate immune response. The exonuclease (ExoN) domain of its nucleoprotein (NP) is implicated in the suppression of retinoic acid-inducible gene I (RIG-I) signaling. We show here that a LASV in which ExoN function has been abolished strongly activates innate immunity and that this effect is dependent on RIG-I signaling. These results highlight the key role of NP ExoN function in the immune evasion that occurs during LASV infection.

  17. Joint bidding restriction policy for selective E and P firms in the US Gulf of Mexico OCS: How persuasive is its effectiveness?

    Energy Technology Data Exchange (ETDEWEB)

    Iledare, Omowumi O.; Pulsipher, Allan G. [Louisiana State University, Baton Rouge, LA (United States). Center for Energy Studies

    2007-06-15

    The principal Minerals Management Service (MMS) policy or regulation intended to promote competition (or inhibit collusion) in the lease market is the Restricted Joint Bidders List. It is compiled and published twice a year and applies to all lease sales held during the subsequent six-month period or until the next list is issued. This paper applies descriptive and econometric analyses to data on lease sales in the US Gulf of Mexico OCS region to evaluate the effectiveness of this policy. In the aggregate, empirical analyses suggest that the imposition of joint bid restrictions on some E and P firms reduces bidding effectiveness for petroleum leases on the OCS. The patterns of bidding for leases on the OCS by E and P firms restricted from bidding jointly do not seem to indicate anticompetitive behavior. Further, joint bidding is found to be consistently associated with higher average high bids and this seems to be consistent with, and perhaps enhances competition in the lease market. (author)

  18. DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

    Science.gov (United States)

    Tasdogan, Alpaslan; Kumar, Suresh; Allies, Gabriele; Bausinger, Julia; Beckel, Franziska; Hofemeister, Helmut; Mulaw, Medhanie; Madan, Vikas; Scharfetter-Kochanek, Karin; Feuring-Buske, Michaela; Doehner, Konstanze; Speit, Günter; Stewart, A Francis; Fehling, Hans Joerg

    2016-12-01

    Mouse mutants with an impaired DNA damage response frequently exhibit a set of remarkably similar defects in the HSPC compartment that are of largely unknown molecular basis. Using Mixed-Lineage-Leukemia-5 (Mll5)-deficient mice as prototypical examples, we have identified a mechanistic pathway linking DNA damage and HSPC malfunction. We show that Mll5 deficiency results in accumulation of DNA damage and reactive oxygen species (ROS) in HSPCs. Reduction of ROS efficiently reverses hematopoietic defects, establishing ROS as a major cause of impaired HSPC function. The Ink4a/Arf locus also contributes to HSPC phenotypes, at least in part via promotion of ROS. Strikingly, toxic ROS levels in Mll5(-/-) mice are critically dependent on type 1 interferon (IFN-1) signaling, which triggers mitochondrial accumulation of full-length Bid. Genetic inactivation of Bid diminishes ROS levels and reverses HSPC defects in Mll5(-/-) mice. Overall, therefore, our findings highlight an unexpected IFN-1 > Bid > ROS pathway underlying DNA damage-associated HSPC malfunction.

  19. 浅谈工程施工投标技巧%Discussion on Project Construction Bidding Skills

    Institute of Scientific and Technical Information of China (English)

    王震宇

    2012-01-01

    With the development of economic conditions, market competition becomes increasingly intense. In project tendering process, a prerequisite for the successful bidding of bidding companies is a reasonable budget and investment quotes. Therefore, the tender offer is the key to the construction tender, and the accurate or not tender offer is directly related to the economic interests of construction units. So, the bid quotation must be effectively and reasonably controlled. The paper discussed the issue and talked about awareness and use of the budget and tender offer skills.%目前,随着经济条件的发展,市场竞争日趋白热化.在工程招标的过程中,投标企业能否取胜的先决条件来自于能否合理进行预算和投资报价.因此,投标报价是工程施工投标的关键,准确与否直接关系建设单位及施工单位的经济利益,所以,就必须对工程投标报价工作进行有效合理的控制,本文就这一问题展开论述,谈谈预算和投标报价技巧的认知和运用.

  20. ADVANCES IN SIGNALING PATHWAYS AND REGULATION OF RIG-I-LIKE RECEPTOR%RIG-I样受体信号通路及其调控研究进展

    Institute of Scientific and Technical Information of China (English)

    丁云磊; 孙英杰; 王晓旭; 胡跃; 费荣梅; 丁铲

    2014-01-01

    The RIG-I-like receptors (RLRs) family of pattern recognition receptors (PRRs) is a group of cytosolic RNA helicase proteins that can identify viral RNA as non-self via binding to pathogen associated molecular pattern (PAMP) motifs within RNA ligands. This interaction then leads to triggering of an innate antiviral response within the infected cells through RLR induction of downstream effector molecules such as type I interferon (IFN) and other proinflammatory cytokines that serve to induce antiviral and inflammatory gene expression. In this paper, the composition of the RLR signaling pathway and regulation of ubiquitination reaction are described briefly. The mechanisms of viruses targeting RLR pathways to escape from the immune response are also summarized. Furthermore, the signaling crosstalk between RLR pathways and NOD-like receptor (NLR) pathways are introduced. Understanding the pivotal role of RLRs in immune regulation and signaling crosstalk in antiviral immunity may provide new insights into therapeutic strategies for the control of virus infection and immunity.%模式识别受体(pattern-recognition receptors,PRRs)中的RIG-I样受体(RIG-I like receptors,RLRs)是细胞质中一类RNA解旋酶,它们可以通过其RNA配体结合病原相关分子模式(pathogen associated molecular pattern,PAMP),识别非自身的病毒RNA。被感染的细胞中,这种相互作用可以通过触发RLRs以及下游信号分子的活化,最终导致I型干扰素的产生和炎性因子的产生,细胞做出抗病毒免疫应答。本文简单介绍了RLR信号通路的组成及其泛素化调控,总结了病毒逃避RLR通路信号转导的机制,最后阐述了NOD样受体(NOD-like receptors,NLRs)通路对RLR通路的影响。通过对RLR信号通路分子在抗病毒免疫调节中的作用了解,可以为控制病毒的感染和免疫调节提供一个新的思路。

  1. BSEA: A Blind Sealed-Bid E-Auction Scheme for E-Commerce Applications

    Directory of Open Access Journals (Sweden)

    Rohit Kumar Das

    2016-12-01

    Full Text Available Due to an increase in the number of internet users, electronic commerce has grown significantly during the last decade. Electronic auction (e-auction is one of the famous e-commerce applications. Even so, security and robustness of e-auction schemes still remain a challenge. Requirements like anonymity and privacy of the b i d value are under threat from the attackers. Any auction protocol must not leak the anonymity and the privacy of the b i d value of an honest Bidder. Keeping these requirements in mind, we have firstly proposed a controlled traceable blind signature scheme (CTBSS because e-auction schemes should be able to trace the Bidders. Using CTBSS, a blind sealed-bid electronic auction scheme is proposed (BSEA. We have incorporated the notion of blind signature to e-auction schemes. Moreover, both the schemes are based upon elliptic curve cryptography (ECC, which provides a similar level of security with a comparatively smaller key size than the discrete logarithm problem (DLP based e-auction protocols. The analysis shows that BSEA fulfills all the requirements of e-auction protocol, and the total computation overhead is lower than the existing schemes.

  2. Meeting the Northwest's Energy Needs Through Competitive Bidding.

    Energy Technology Data Exchange (ETDEWEB)

    McCoy, Gilbert A.; Bloomquist, R. Gordon

    1990-07-01

    Utilities have traditionally met load growth requirements through building projects (self-build), purchasing power from other utilities, or from running conservation programs. During the 1980s, alternative capacity expansion approaches were developed. Resources are now also obtained through PURPA-based or competitive bidding acquisition programs. Self-build programs typically involve large-scale hydropower; coal-, natural gas-, and oil-fired projects; and nuclear thermal electric generating projects. Characteristics of these projects, in addition to size, include long lead times, capital intensiveness, substantial environmental impacts, and a significant risk of cost overruns. The risk element became immediately apparent to those investor-owned utilities that, because of decreased load growth, had thermal project investments disallowed in rate cases or were forced to terminate projects. Phrases such as prudent investment,'' used and useful,'' and least-cost planning'' became familiar to the utility industry. Many utilities, once burned, subsequently adopted a policy of never again constructing a base-loaded generating plant. 2 figs.

  3. Use of Markov Chains to Design an Agent Bidding Strategy for Continuous Double Auctions

    CERN Document Server

    Birmingham, W P; Park, S; 10.1613/jair.1466

    2011-01-01

    As computational agents are developed for increasingly complicated e-commerce applications, the complexity of the decisions they face demands advances in artificial intelligence techniques. For example, an agent representing a seller in an auction should try to maximize the seller?s profit by reasoning about a variety of possibly uncertain pieces of information, such as the maximum prices various buyers might be willing to pay, the possible prices being offered by competing sellers, the rules by which the auction operates, the dynamic arrival and matching of offers to buy and sell, and so on. A naive application of multiagent reasoning techniques would require the seller?s agent to explicitly model all of the other agents through an extended time horizon, rendering the problem intractable for many realistically-sized problems. We have instead devised a new strategy that an agent can use to determine its bid price based on a more tractable Markov chain model of the auction process. We have experimentally ident...

  4. The bid to lose weight: impact of social media on weight perceptions, weight control and diabetes.

    Science.gov (United States)

    Das, Leah; Mohan, Ranjini; Makaya, Tafadzwa

    2014-01-01

    Over the last decade the internet has come to permeate every aspect of our lives. With huge leaps in accessibility of the internet via mobile personal devices such as smart cellular phones and tablets, individuals are connected to the internet virtually all the time. It is no surprise therefore that social media now dominates the lives of many people within society. The authors take a look at how social media is influencing diabetes with particular focus on weight perception, weight management and eating behaviours. The authors explore the concept of how the advertising of Size 0 models and photo-shopping of images which are easily available on line and via social media is causing an increase in the number of young people with distorted body images. This has led to an increased number of people resorting to sometimes drastic weight loss programmes. We focus on the bid for 'low-fat' consumption and highlight how this could actually be leading to an increased risk for developing diabetes or worsening the complications of diabetes. We also discuss the increase of eating disorder in diabetes related to this distorted body image.

  5. Optimal Bidding of a Microgrid Based on Probabilistic Analysis of Island Operation

    Directory of Open Access Journals (Sweden)

    Siyoung Lee

    2016-10-01

    Full Text Available Island operation of a microgrid increases operation survivability and reliability when there is a large accident in a main grid. However, because a microgrid typically has limited generation capability, a microgrid operator (MGO has to take the risk of island operation into account in its market participation and generation scheduling to ensure efficient operation. In this paper, a microgrid islanding event is interpreted as a trade suspension of a contract, and a set of islanding rules is presented in the form of a market rule. The risk of island operation is evaluated by modeling the microgrid islanding stochastically using an islanding probability function, which is defined in the form of a conditional probability to reflect the influence of outside conditions. An optimal bidding strategy is obtained for the MGO by formulating and solving an optimization problem to minimize the expected operating cost. The effectiveness of the proposed method was investigated by numerical simulations in which the proposed method and two other methods were applied to the same microgrid. Numerical sensitivity analyses of the coefficients of the islanding probability function were conducted to determine how an MGO copes with changes in outside conditions.

  6. Del MERCOSUR al ALCA: críticas al modelo liberal de nuevo regionalismo del BID

    Directory of Open Access Journals (Sweden)

    Alexis Saludjian

    2005-01-01

    Full Text Available En la primera sección se discute un modelo del Banco Interamericano de Desarrollo (BID en favor del ALCA, sobre la base de la aplicación de la teoría de economía geográfica al proceso de integración económica del Cono Sur de América Latina (MERCOSUR. En la segunda sección, abordamos los límites de este modelo, insistiendo en la ausencia de ciertas variables fundamentales para el estudio de las economías de estas regiones. Por cierto, los aspectos de las economías industrial internacional, del desarrollo y de la inserción de estos países de la periferia en la economía mundial, son esenciales para analizar el régimen de acumulación dominado por el espacio financiero que la mayoría de las naciones latinoamericanas experimentan, así como el proceso de integración de América.

  7. THE TECHNOLOGY ASSESSMENT OF DEMAND SIDE BIDDING IN THE SOUTH AFRICAN CONTEXT*

    Directory of Open Access Journals (Sweden)

    H.K. Grover

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT:South Africa is currently in the grip of a severe power supply capacity constraint. January 2007 saw blackouts throughout the country, and worse was expected in the months to come. As a measure of immediate remedy Eskom has turned to demand side bidding (DSB, a methodology whereby the demand side has an opportunity to sell back flexible load to the supply side. This paper assesses DSB with the aim of evaluating and gauging the current and potential future standing of DSB as a technology product within the South African context.

    AFRIKAANSE OPSOMMING: Suid-Afrika ervaar tans ’n ernstige vraagstuk in elektrisiteitsvoorsiening. Vanaf Januarie 2007 kom gereelde kragonderbrekings voor, en volgens alle aanduidings lê die ergste nog voor. As ’n korttermynmaatreël beoog ESKOM ’n strategie van aanvraagbestuur en spesifiek aanvraag-bie, ’n metodologie waarvolgens verbruikers die geleentheid kry om elektrisiteit aan die verskaffer terug te verkoop. Hierdie artikel assesseer die metodologie ten einde die huidige en toekomstige gebruikersmoontlikhede daarvan as ’n tegnologieproduk binne Suid-Afrikaanse konteks te bepaal.

  8. Performance Evaluation of Bidding-Based Multi-Agent Scheduling Algorithms for Manufacturing Systems

    Directory of Open Access Journals (Sweden)

    Antonio Gordillo

    2014-10-01

    Full Text Available Artificial Intelligence techniques have being applied to many problems in manufacturing systems in recent years. In the specific field of manufacturing scheduling many studies have been published trying to cope with the complexity of the manufacturing environment. One of the most utilized approaches is (multi agent-based scheduling. Nevertheless, despite the large list of studies reported in this field, there is no resource or scientific study on the performance measure of this type of approach under very common and critical execution situations. This paper focuses on multi-agent systems (MAS based algorithms for task allocation, particularly in manufacturing applications. The goal is to provide a mechanism to measure the performance of agent-based scheduling approaches for manufacturing systems under key critical situations such as: dynamic environment, rescheduling, and priority change. With this mechanism it will be possible to simulate critical situations and to stress the system in order to measure the performance of a given agent-based scheduling method. The proposed mechanism is a pioneering approach for performance evaluation of bidding-based MAS approaches for manufacturing scheduling. The proposed method and evaluation methodology can be used to run tests in different manufacturing floors since it is independent of the workshop configuration. Moreover, the evaluation results presented in this paper show the key factors and scenarios that most affect the market-like MAS approaches for manufacturing scheduling.

  9. 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

    Directory of Open Access Journals (Sweden)

    García-Sastre Adolfo

    2010-05-01

    Full Text Available Abstract Background Emergence of drug-resistant strains of influenza viruses, including avian H5N1 with pandemic potential, 1918 and 2009 A/H1N1 pandemic viruses to currently used antiviral agents, neuraminidase inhibitors and M2 Ion channel blockers, underscores the importance of developing novel antiviral strategies. Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I has recently been shown to induce antiviral state. Results In the present investigation, using real time RT-PCR, immunofluorescence, immunoblot, and plaque assay we show that 5'PPP-containing single stranded RNA (5'PPP-RNA, a ligand for the intracytoplasmic RNA sensor, RIG-I can be used as a prophylactic agent against known drug-resistant avian H5N1 and pandemic influenza viruses. 5'PPP-RNA treatment of human lung epithelial cells inhibited replication of drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza viruses in a RIG-I and type 1 interferon dependant manner. Additionally, 5'PPP-RNA treatment also inhibited 2009 H1N1 viral replication in vivo in mice. Conclusions Our findings suggest that 5'PPP-RNA mediated activation of RIG-I can suppress replication of influenza viruses irrespective of their genetic make-up, pathogenicity, and drug-sensitivity status.

  10. Aging Jack-Up Rig Fleet in Need of 200 NewbuUds BY ROB ALMEIDA ON JUNE 22,2012-6-26

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    At the 25th annual Marine Money conference in New York this week, Andreas Stubsrud, Head of Research at Pareto Securities, predicted a need for 200 new jack up rigs as nearly half of the 450 jack ups worldwide approach their 40th birthdays by 2020.

  11. Micro-pyrolysis of technical lignins in a new modular rig and product analysis by GC-MS/FID and GC x GC-TOFMS/FID

    NARCIS (Netherlands)

    Windt, Michael; Meier, Dietrich; Marsman, Jan Henk; Heeres, Hero Jan; de Koning, Sjaak

    2009-01-01

    A new offline-pyrolysis rig has been designed to allow multifunctional experiments for preparative and analytical purposes. The system conditions can be set and monitored, e.g. temperature, its gradients and heat flux. Some special features include ( I) high heating rates up to 120 degrees C/s with

  12. Experimental Analysis of Mast Lifting and Bending Forces on Vibration Patterns Before and After Pinion Reinstallation in an OH-58 Transmission Test Rig

    Science.gov (United States)

    Huff, Edward M.; Lewicki, David G.; Tumer, Irem Y.; Decker, Harry; Barszez, Eric; Zakrajsek, James J.; Norvig, Peter (Technical Monitor)

    2000-01-01

    As part of a collaborative research program between NASA Ames Research Center (ARC), NASA Glenn Research Center (GRC), and the US Army Laboratory, a series of experiments is being performed in GRC's 500 HP OH-58 Transmission Test Rig facility and ARC's AH-I Cobra and OH-58c helicopters. The findings reported in this paper were drawn from Phase-I of a two-phase test-rig experiment, and are focused on the vibration response of an undamaged pinion gear operating in the transmission test rig. To simulate actual flight conditions, the transmission system was run at three torque levels, as well as two mast lifting and two mast bending levels. The test rig was also subjected to disassembly and reassembly of the main pinion housing to simulate the effect of maintenance operations. An analysis of variance based on the total power of the spectral distribution indicates the relative effect of each experimental factor, including Wong interactions with torque. Reinstallation of the main pinion assembly is shown to introduce changes in the vibration signature, suggesting the possibility of a strong effect of maintenance on HUMS design and use. Based on these results, further research will be conducted to compare these vibration responses with actual OH58c helicopter transmission vibration patterns.

  13. Inlet flow test calibration for a small axial compressor rig. Part 2: CFD compared with experimental results

    Science.gov (United States)

    Miller, D. P.; Prahst, P. S.

    1995-01-01

    An axial compressor test rig has been designed for the operation of small turbomachines. A flow test was run to calibrate and determine the source and magnitudes of the loss mechanisms in the compressor inlet for a highly loaded two-stage axial compressor test. Several flow conditions and inlet guide vane (IGV) angle settings were established, for which detailed surveys were completed. Boundary layer bleed was also provided along the casing of the inlet behind the support struts and ahead of the IGV. Several computational fluid dynamics (CFD) calculations were made for selected flow conditions established during the test. Good agreement between the CFD and test data were obtained for these test conditions.

  14. Efficient thermal cycling of solar panels in solar simulation facilities with a multi-panel test rig

    Science.gov (United States)

    Brinkmann, P. W.; Reimann, J.

    1980-06-01

    It is shown that efficient thermal cycling tests under vacuum can be performed at reduced costs to cover the requirements for qualifications and acceptance testing of solar panels. A suitable test rig was developed which allows simultaneous testing of up to 3 solar panels with a dimension of 1.3 m x 1.7 m each. The tests can be performed in an existing solar simulation facility with a beam diameter of only 2.4 m. This means that a close simulation of orbital conditions can be achieved, including severe eclipse conditions with rapid temperature changes. Chamber dimensions, descriptions of suspension devices, and other data needed by potential users are given.

  15. In Situ Measurement of Discomfort Curves for Seated Subjects in a Car on the Four-Post Rig

    Directory of Open Access Journals (Sweden)

    T. Ibicek

    2014-01-01

    Full Text Available The aim of this study is to measure and quantify perceived intensity of discomfort due to vibration in a vehicle in situ considering complete vehicle dynamic behaviour. The shaker table based discomfort curves or the road test results may not accurately and universally indicate the true level of human discomfort in a vehicle. A new experimental method, using a seated human in a car on the four-post rig simulator, is proposed to quantify discomfort. The intensity of perception to vibration decreased with decreasing input and increasing frequency; the rate of change is different from the published literature; the difference is large for angular modes of inputs. Vehicle dynamic response is used to inform and analyse the results. The repeatability of the method and the fact that they are in situ measurements may eventually help reduce reliance on the road tests. Furthermore, discomfort curves obtained, subsequently, can be used in predictive models.

  16. Does the Lowest Bid Price Evaluation Criterion Make for a More Efficient Public Procurement Selection Criterion? (Case of the Czech Republic

    Directory of Open Access Journals (Sweden)

    Ochrana František

    2015-06-01

    Full Text Available Through the institute of public procurement a considerable volume of financial resources is allocated. It is therefore in the interest of contracting entities to seek ways of how to achieve an efficient allocation of resources. Some public contract-awarding entities, along with some public-administration authorities in the Czech Republic, believe that the use of a single evaluation criterion (the lowest bid price results in a more efficient tender for a public contract. It was found that contracting entities in the Czech Republic strongly prefer to use the lowest bid price criterion. Within the examined sample, 86.5 % of public procurements were evaluated this way. The analysis of the examined sample of public contracts proved that the choice of an evaluation criterion, even the preference of the lowest bid price criterion, does not have any obvious impact on the final cost of a public contract. The study concludes that it is inappropriate to prefer the criterion of the lowest bid price within the evaluation of public contracts that are characterised by their complexity (including public contracts for construction works and public service contracts. The findings of the Supreme Audit Office related to the inspection of public contracts indicate that when using the lowest bid price as an evaluation criterion, a public contract may indeed be tendered with the lowest bid price, but not necessarily the best offer in terms of supplied quality. It is therefore not appropriate to use the lowest bid price evaluation criterion to such an extent for the purpose of evaluating work and services. Any improvement to this situation requires a corresponding amendment to the Law on Public Contracts and mainly a radical change in the attitude of the Office for the Protection of Competition towards proposed changes, as indicated within the conclusions and recommendations proposed by this study.

  17. Importance of International Project Bidding Management and Planning%国际工程投标管理规划的重要性

    Institute of Scientific and Technical Information of China (English)

    李传海

    2012-01-01

    In the fierce competition in the international construction market, the construction enterprise how to face the complicated and volatile international situation and environment influence factors to compile and sub- mit a bidding documents with advanced technology, reasonable economy and competitiveness bidding is a key research content of management unit or departments in project bidding, is also an important compre- hensive subject of keeping sustainable development. This combination combines the international engi- neering bidding practice and related engineering experience in recent years to discuss the control meas- ures of compiling bidding documents in the project bidding management and eonstruction management ac- cording to the importance of making international project bidding management and planning.%在国际建筑市场的激烈竞争中,施工企业如何面对复杂多变的国际形势和环境影响因素,针对招标项目编制提交一份完全符合招标文件要求,且技术先进、经济合理又富有竞争力的投标文件,是经营管理单位或部门在工程投标阶段需要研究的重点工作内容,也是企业保持可持续发展的一个重要综合性课题。此文结合近年来国际工程投标实践及相关工程经验,从制订国际工程投标管理规划的重要性入手,论述工程投标管理与施工管理有效结合编制投标文件和报价应采取的控制措施。

  18. Optimal Bidding Strategies for a Small Generation Company in a Day-Ahead Electricity Market with Bilateral Contracts Taken into Account

    Directory of Open Access Journals (Sweden)

    Azmi Saleh

    2009-01-01

    Full Text Available Problem Statement: Deregulation power systems have been force to change their structures, from vertically integrated to open market systems. Each generation company (Genco is required to compete with rivals through bidding in a pool market and making a bilateral contract with a distribution company (Disco or consumers to maximize its own profits. A unit commitment becomes responsible for each Genco and difficult for Genco that have one generation plant or small generation capacity. The objective of a Genco is to maximize its profits with makes a decision submit bidding price function to the Independent System Operator (ISO. In order to achieve this goal, it is necessary and important for a small Genco to build optimal bidding strategies considering a bilateral contract and a unit commitment with constraints in time periods for possibilities to get a discontinuous dispatch that could reduce total profits. Approach: The proposed methodology employs an optimization method like Lagrange Relaxation to solve the optimal bidding problem. The solution procedure is applied in the study case and change the market condition to show the effect of bilateral contract to marginal clearing price (MCP, generation output and total profit for a small Genco. Result: The result of the proposed method shows that a Genco can build optimal bidding strategies to maximize total profit considering unit commitment and bilateral contract. Simulation results of a numerical example have demonstrated the bilateral contract reduced the hourly MCP. The bilateral contract will guarantee the Genco getting continuous dispatch during time periods. Conclusions/Recommendations: The proposed method for building optimal bidding strategies in a day-ahead electricity market to maximize total profit considering unit commitment and bilateral contract is helpful for a Genco to make decision in submit bidding to an ISO.

  19. Development of ZJ50/3150LDB-1 Drilling Rig%ZJ50/3150LDB-1型钻机研制

    Institute of Scientific and Technical Information of China (English)

    温晓莉; 田建新; 赵学锋; 齐国忠

    2011-01-01

    In order to adapt to the needs of the modern drilling rig, based on summing up the features of the original ZJ50/3150LDB drilling rig,ZJ50/3150LDB-1 drilling rig is developed. It features in operational safety,simple structure,reliable performance. In the situation of having no use for stringing,it can implemented one stringing,and double lifting;the dog house is lifted together with rear substructure;high and low speed of drawworks drum is adopted with electric control,so the speed of clutch on off is quick;the rotary table is driven dependently. ZJ50/3150LDB-1 drilling rig is a great market potential for development drilling rig.%为适应现代钻井的需要,在总结ZJ50/3150LDB型钻机特点的基础上,研制了ZJ50/3150LDB-1型钻机.该钻机操作安全,结构简单,性能稳定可靠;能够在不倒绳的情况下实现1次穿绳、2次起升;司钻偏房与前台底座一起起升;绞车高、低速采用电控摘开、挂合,反应速度快;转盘采用电机独立驱动,是一种具有市场发展潜力的钻机.

  20. Construction of pCMV-Myc-RIG-I-2CARD vector and its expression and localization in HeLa cells%RIG-I蛋白2CARD结构域真核表达载体的构建及其在HeLa细胞中的表达定位

    Institute of Scientific and Technical Information of China (English)

    张丽丽; 程丽鑫; 张华; 曹宏伟; 杨琦; 闫江翠; 张雅婷; 陈宁; 丁筠; 邹德华; 李兴志; 郑亮

    2016-01-01

    Objective To construct pCMV-Myc-RIG-I-2CARD vector and give its expression and localization in HeLa cells.Methods Retinoic acid inducible gene-I (RIG-I) as the pattern recognition receptor, can participate in the MAVS-mediated NF-κB innate anti-viral immune response. Caspase activation and recruitment domain (CARD) is two repeatable caspase activation recruiting areas on the N-terminal of RIG-I. In the processes virus infection, 2CARD domain plays important roles in recognizing and priming immune response. In this study, 2CARD gene was amplified with PCR method, and then was inserted into pCMV-Myc plasmid. The obtained pCMV-Myc-RIG-I-2CARD was transfected into HeLa cells, and the expression of 2CARD gene was confirmed by Western Blot and immunofluorescent. Results The result showed that the 2CARD fusion protein was successfully expressed in HeLa cells. Conclusions This research constructs the pCMV-Myc-RIG-I-2CARD vector, through 2CARD fusion protein successfully expressed in HeLa cells, establishes a foundation to further studies of interactions between virus and RIG-I.%目的:构建 RIG-I 蛋白2CARD 结构域真核表达载体及其在 HeLa 细胞中的表达定位。方法 RIG-I是一种模式识别受体,它能够参与由 MAVS 介导的 NF-κB 天然抗病毒免疫反应。2CARD (Caspase activation and recruitment domain,CARD)结构域是视黄酸诱导基因-I(Retinoin acid inducible gene I,RIG-I)N 端的2个串联重复的半胱天冬酶激活招募区,在病毒侵染细胞过程中,2CARD 结构域发挥了识别并启动机体免疫应答的功能。本研究通过 PCR 获取2CARD 片段酶切后,与 pCMV-Myc 载体连接后转染 HeLa 细胞,在 HeLa 细胞中表达,并应用 Western Blot 和免疫荧光进行鉴定。结果2CARD 基因在HeLa 细胞中成功表达。结论本研究成功构建了 pCMV-Myc-RIG-I-2CARD 真核表达载体,通过将 RIG-I分子中负责信号转导的2CARD 在 HeLa 中表达,为研究病毒与 RIG-I 的互作关系奠定一定的基础。