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  1. A Study of Stranding of Juvenile Salmon by Ship Wakes Along the Lower Columbia River Using a Before-and-After Design: Before-Phase Results

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Walter H.; Skalski, J R.; Sobocinski, Kathryn L.; Miller, Martin C.; Johnson, Gary E.; Williams, Greg D.; Southard, John A.; Buchanan, Rebecca A.

    2006-02-01

    Ship wakes produced by deep-draft vessels transiting the lower Columbia River have been observed to cause stranding of juvenile salmon. Proposed deepening of the Columbia River navigation channel has raised concerns about the potential impact of the deepening project on juvenile salmon stranding. The Portland District of the U.S. Army Corps of Engineers requested that the Pacific Northwest National Laboratory design and conduct a study to assess stranding impacts that may be associated with channel deepening. The basic study design was a multivariate analysis of covariance of field observations and measurements under a statistical design for a before and after impact comparison. We have summarized field activities and statistical analyses for the ?before? component of the study here. Stranding occurred at all three sampling sites and during all three sampling seasons (Summer 2004, Winter 2005, and Spring 2005), for a total of 46 stranding events during 126 observed vessel passages. The highest occurrence of stranding occurred at Barlow Point, WA, where 53% of the observed events resulted in stranding. Other sites included Sauvie Island, OR (37%) and County Line Park, WA (15%). To develop an appropriate impact assessment model that accounted for relevant covariates, regression analyses were conducted to determine the relationships between stranding probability and other factors. Nineteen independent variables were considered as potential factors affecting the incidence of juvenile salmon stranding, including tidal stage, tidal height, river flow, current velocity, ship type, ship direction, ship condition (loaded/unloaded), ship speed, ship size, and a proxy variable for ship kinetic energy. In addition to the ambient and ship characteristics listed above, site, season, and fish density were also considered. Although no single factor appears as the primary factor for stranding, statistical analyses of the covariates resulted in the following equations: (1) Stranding

  2. Quality of Reporting and Study Design of CKD Cohort Studies Assessing Mortality in the Elderly Before and After STROBE: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    Anirudh Rao

    Full Text Available The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE statement was published in October 2007 to improve quality of reporting of observational studies. The aim of this review was to assess the impact of the STROBE statement on observational study reporting and study design quality in the nephrology literature.Systematic literature review.European and North American, Pre-dialysis Chronic Kidney Disease (CKD cohort studies.Studies assessing the association between CKD and mortality in the elderly (>65 years published from 1st January 2002 to 31st December 2013 were included, following systematic searching of MEDLINE & EMBASE.Time period before and after the publication of the STROBE statement.Quality of study reporting using the STROBE statement and quality of study design using the Newcastle Ottawa Scale (NOS, Scottish Intercollegiate Guidelines Network (SIGN and Critical Appraisal Skills Programme (CASP tools.37 papers (11 Pre & 26 Post STROBE were identified from 3621 potential articles. Only four of the 22 STROBE items and their sub-criteria (objectives reporting, choice of quantitative groups and description of and carrying out sensitivity analysis showed improvements, with the majority of items showing little change between the period before and after publication of the STROBE statement. Pre- and post-period analysis revealed a Manuscript STROBE score increase (median score 77.8% (Inter-quartile range [IQR], 64.7-82.0 vs 83% (IQR, 78.4-84.9, p = 0.05. There was no change in quality of study design with identical median scores in the two periods for NOS (Manuscript NOS score 88.9, SIGN (Manuscript SIGN score 83.3 and CASP (Manuscript CASP score 91.7 tools.Only 37 Studies from Europe and North America were included from one medical specialty. Assessment of study design largely reliant on good reporting.This study highlights continuing deficiencies in the reporting of STROBE items and their sub-criteria in cohort

  3. Physics before and after Einstein

    CERN Document Server

    Capria, M Mamone

    2005-01-01

    It is now a century ago that one of the icons of modern physics published some of the most influential scientific papers of all times. With his work on relativity and quantum theory, Albert Einstein has altered the field of physics forever. It should not come as a surprise that looking back at Einstein''s work, one needs to rethink the whole scope of physics, before and after his time. This books aims to provide a perspective on the history of modern physics, spanning from the late 19th century up to today. It is not an encyclopaedic work, but it presents the groundbreaking and sometimes provocative main contributions by Einstein as marking the line between ''old'' and ''new'' physics, and expands on some of the developments and open issues to which they gave rise.

  4. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

    DEFF Research Database (Denmark)

    Koivula, Robert W.; Heggie, Alison; Barnett, Anna;

    2014-01-01

    biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper...

  5. Physical Activity before and after School

    Science.gov (United States)

    Beighle, Aaron; Moore, Melanie

    2012-01-01

    This article discusses a variety of before- and after-school programs (BASPs) that can be implemented from preschool through 12th grade. These programs offer physical activity opportunities before and after school for youths of various ages, skill levels, and socioeconomic levels. In addition, strategies for the director of physical activity to…

  6. Sexual Dysfunction before and after Cardiac Rehabilitation

    OpenAIRE

    Jörg Schumann; Zellweger, Michael J.; Marcello Di Valentino; Simone Piazzalonga; Andreas Hoffmann

    2010-01-01

    Background. The aim of this study was to assess sexual function before and after cardiac rehabilitation in relation to medical variables. Methods. Analysis of patients participating in a 12-week exercise-based outpatient cardiac rehabilitation program (OCR) between April 1999 and December 2007. Exercise capacity (ExC) and quality of life including sexual function were assessed before and after OCR. Results. Complete data were available in 896 male patients. No sexual activity at all was indic...

  7. Staff perceptions of work quality of a neonatal intensive care unit before and after transition from an open bay to a private room design.

    Science.gov (United States)

    Smith, Thomas J; Schoenbeck, Kathleen; Clayton, Sandra

    2009-01-01

    This study collected staff responses to an occupancy quality survey before, and 6 and 22 months after, St. Paul Children's Hospitals and Clinics (CHC) replaced an open bay (OB) with a private room (PR) neonatal intensive care unit (NICU) design. Staff interview responses and task activity observations also were collected. The goal was to assess how this change would influence staff perceptions and performance. As a result of the transition from the OB to the PR environment: (1) rankings of overall physical environment, patient care, job, technology, and off-the-job quality significantly improved; but (2) rankings of patient care team interaction quality significantly declined. Results for the 22-month PR survey indicate essentially no meaningful changes in rankings of occupancy quality from the 6-month survey, suggesting no consolidation of quality gains in the intervening 16-month period. Written comments pertaining to private room NICU design issues by survey respondents, targeting problems with unit operations, may explain this finding. Collectively, the findings suggest that NICU operational management was not effectively modified to deal with the new design, and that an OB to PR NICU transition requires a systems approach to macroergonomic challenges imposed by the new design.

  8. VOICE QUALITY BEFORE AND AFTER THYROIDECTOMY

    Directory of Open Access Journals (Sweden)

    Dora CVELBAR

    2016-04-01

    Full Text Available Introduction: Voice disorders are a well-known complication which is often associated with thyroid gland diseases and because voice is still the basic mean of communication it is very important to maintain its quality healthy. Objectives: The aim of this study referred to questions whether there is a statistically significant difference between results of voice self-assessment, perceptual voice assessment and acoustic voice analysis before and after thyroidectomy and whether there are statistically significant correlations between variables of voice self-assessment, perceptual assessment and acoustic analysis before and after thyroidectomy. Methods: This scientific research included 12 participants aged between 41 and 76. Voice self-assessment was conducted with the help of Croatian version of Voice Handicap Index (VHI. Recorded reading samples were used for perceptual assessment and later evaluated by two clinical speech and language therapists. Recorded samples of phonation were used for acoustic analysis which was conducted with the help of acoustic program Praat. All of the data was processed through descriptive statistics and nonparametric statistical methods. Results: Results showed that there are statistically significant differences between results of voice self-assessments and results of acoustic analysis before and after thyroidectomy. Statistically significant correlations were found between variables of perceptual assessment and acoustic analysis. Conclusion: Obtained results indicate the importance of multidimensional, preoperative and postoperative assessment. This kind of assessment allows the clinician to describe all of the voice features and provides appropriate recommendation for further rehabilitation to the patient in order to optimize voice outcomes.

  9. Plasma adiponectin before and after kidney transplantation

    DEFF Research Database (Denmark)

    Idorn, Thomas; Hornum, Mads; Bjerre, Mette;

    2012-01-01

    The role of plasma adiponectin (ADPN) in patients with impaired kidney function and following kidney transplantation (Tx) is debated. We aimed to: (i) determine whether pretransplant ADPN level is an independent risk factor for deterioration of glucose tolerance including development of new......-onset diabetes mellitus after Tx, (ii) describe which parameters that influence the ADPN concentration before and after Tx. Fifty-seven nondiabetic kidney allograft recipients and 40 nondiabetic uraemic patients were included. The Tx group was examined at baseline and 3 and 12 months after Tx. The uraemic...... analysis, whereas an ordinal logistic regression analysis revealed no predictive characteristic of ADPN for aggravation of the glucose tolerance after Tx. In conclusion, kidney transplantation is accompanied by a significant reduction in ADPN concentration. Several factors determine the ADPN concentration...

  10. Happiness: before and after the kids.

    Science.gov (United States)

    Myrskylä, Mikko; Margolis, Rachel

    2014-10-01

    Understanding how having children influences parents' subjective well-being ("happiness") has great potential to explain fertility behavior. We study parental happiness trajectories before and after the birth of a child, using large British and German longitudinal data sets. We account for unobserved parental characteristics using fixed-effects models and study how sociodemographic factors modify the parental happiness trajectories. Consistent with existing work, we find that happiness increases in the years around the birth of a first child and then decreases to before-child levels. Moreover, happiness increases before birth, suggesting that the trajectories may capture not only the effect of the birth but also the broader process of childbearing, which may include partnership formation and quality. Sociodemographic factors strongly modify this pattern. Those who have children at older ages or who have more education have a particularly positive happiness response to a first birth; and although having the first two children increases happiness, having a third child does not. The results, which are similar in Britain and Germany, suggest that having up to two children increases happiness, and mostly for those who have postponed childbearing. This pattern is consistent with the fertility behavior that emerged during the second demographic transition and provides new insights into low and late fertility.

  11. Happiness: before and after the kids.

    Science.gov (United States)

    Myrskylä, Mikko; Margolis, Rachel

    2014-10-01

    Understanding how having children influences parents' subjective well-being ("happiness") has great potential to explain fertility behavior. We study parental happiness trajectories before and after the birth of a child, using large British and German longitudinal data sets. We account for unobserved parental characteristics using fixed-effects models and study how sociodemographic factors modify the parental happiness trajectories. Consistent with existing work, we find that happiness increases in the years around the birth of a first child and then decreases to before-child levels. Moreover, happiness increases before birth, suggesting that the trajectories may capture not only the effect of the birth but also the broader process of childbearing, which may include partnership formation and quality. Sociodemographic factors strongly modify this pattern. Those who have children at older ages or who have more education have a particularly positive happiness response to a first birth; and although having the first two children increases happiness, having a third child does not. The results, which are similar in Britain and Germany, suggest that having up to two children increases happiness, and mostly for those who have postponed childbearing. This pattern is consistent with the fertility behavior that emerged during the second demographic transition and provides new insights into low and late fertility. PMID:25143019

  12. Sexual Dysfunction before and after Cardiac Rehabilitation

    Directory of Open Access Journals (Sweden)

    Jörg Schumann

    2010-01-01

    variables. Methods. Analysis of patients participating in a 12-week exercise-based outpatient cardiac rehabilitation program (OCR between April 1999 and December 2007. Exercise capacity (ExC and quality of life including sexual function were assessed before and after OCR. Results. Complete data were available in 896 male patients. No sexual activity at all was indicated by 23.1% at baseline and 21.8% after OCR, no problems with sexual activity by 40.8% at baseline and 38.6% after OCR. Patients showed an increase in specific problems (erectile dysfunction and lack of orgasm from 18% to 23% (<.0001 during OCR. We found the following independent positive and negative predictors of sexual problems after OCR: hyperlipidemia, age, CABG, baseline ExC and improvement of ExC, subjective physical and mental capacity, and sense of affiliation. Conclusions. Sexual dysfunction is present in over half of the patients undergoing OCR with no overall improvement during OCR. Age, CABG, low exercise capacity are independent predictors of sexual dysfunction after OCR.

  13. Opioid prescriptions before and after high-energy trauma

    DEFF Research Database (Denmark)

    Zwisler, Stine T; Hallas, Jesper; Larsen, Morten S;

    2015-01-01

    OBJECTIVE: To describe the legal use of opioids in adult patients before and after high-energy trauma. DESIGN: The study was a retrospective database study. SETTING: Clinical care outside hospitals. PATIENTS: All patients who suffered high-energy trauma and were brought to Odense University...... Hospital (OUH), Denmark, in 2007 and 2008 were retrieved from the trauma database. These patients were linked with data on opioid use from the regional prescription database. In all, 938 patients were included. MAIN OUTCOME MEASURE: Redemption of opioid prescription during the 6 months prior...... to a multitrauma or redemption of two or more prescriptions for opioids 6 months or later after a multitrauma. RESULTS: Of the 938 patients brought to OUH with severe trauma within the study period, 61 patients died (7 percent) and six of these had redeemed prescriptions for opioids within 6 months prior...

  14. Research on Difference Design Modeling of Embroidered Insoles Before and After Reforming and Opening in Qilu Region%改革开放前后齐鲁地区绣花鞋垫图案造型比较

    Institute of Scientific and Technical Information of China (English)

    王秀丽; 张竞琼

    2012-01-01

    The embroidered insole is one of the traditional folk arts in Qilu area of China.It shows respective characteristics in corresponding period.The form and pattern of embroidered insole before and after the reform and opening are compared based on fieldwork and study on Southern Yangtze University Folk Clothing and Accessory Museum.It is shown that the pattern after the reform and opening is more mature and varied which is of great significance to the inheritance and development of the folk art.%绣花鞋垫是我国齐鲁地区传统民间艺术之一,改革开放前后的绣花鞋垫呈现出不同的特征。通过实地采风考察和对江南大学传习馆现存鞋垫的研究,主要从图案的题材、寓意与形式构成等方面比较了改革开放前后齐鲁地区绣花鞋垫的变化,从而得出改革开放后的绣花鞋垫图案更加成熟、多样化的结论,并分析产生这种变化的原因,对于该民间文化的传承和发展具有重要的意义。

  15. Strength and Flexibility in Gymnasts Before and After Menarche.

    Science.gov (United States)

    Haywood, Kathleen M.

    Twenty female gymnasts between the ages of twelve and fourteen were tested to determine possible difference in strength and flexibility before and after the development of an active menstrual cycle. Results indicate that females participating in gymnastics on a seriously competitive level tend to be short and light for their ages, as well as to…

  16. Morphological characteristics of spermatozoa before and after renal transplantation

    Institute of Scientific and Technical Information of China (English)

    Long-Gen Xu; Shi-Fang Shi; Xiao-Ping Qi; Xiao-Feng Huang; Hui-Ming Xu; Qi-Zhe Song; Xing-Hong Wang; Zong-Fu Shao; Jun-Rong Zhang

    2005-01-01

    Aim: To investigate the changes of the spermatozoa ultrastructures before and after renal transplantation in uremic patients. Methods: The sperm of five uremic patients before and after transplantation and four healthy volunteers were collected and examined by scanning electron microscopy. Results: Abnormal spermatozoa were found in patients pre-transplantation; abnormalities included deletion of the acrosome, absence of the postacrosomal and postnuclear ring, dumbbell-like changes of the head, tail curling, and absence of the mitochondrial sheath in the midsegment. After renal transplantation, most of the spermatozoa became normal. Conclusion: There are many abnormalities with regard to the appearance and structure of the head, acrosome, mitochondria and tail of the spermatozoa in uremic patients. The majority of the spermatozoa returned to normal after renal transplantation, but a few still presented some abnormalities possibly relating to the administration of immunosuppressants.

  17. Saliva in relation to dental erosion before and after radiotherapy

    DEFF Research Database (Denmark)

    Jensdottir, Thorbjorg; von Buchwald, Christian; Nauntofte, Birgitte;

    2013-01-01

    Abstract Objective. Low saliva flow and abnormal saliva composition are common conditions after radiotherapy for oral cavity and pharyngeal cancer. Both conditions increase the susceptibility to dental caries and erosion, which may be further accelerated by changes in food preferences. The aim...... of this study was to determine changes in saliva flow and susceptibility to erosive challenges in pharyngeal cancer patients before and after radiotherapy to the head and neck. Materials and methods: The erosive potential of sucking acidic candies with and without calcium was determined in nine patients (50......-68 years) before and after receiving a radiation dose of 66 Gy to the head and neck area. The erosive potential was evaluated from saliva degree of saturation with respect to hydroxyapatite (HAp) and by dissolution of HAp in candy-stimulated saliva. Results. Sucking acidic candies increased saliva flow...

  18. Antioxidant status in neonatal jaundice before and after phototherapy

    OpenAIRE

    Dahiya, Kiran; Tiwari, A. D.; Shankar, Vijay; Kharb, Simmi; Dhankhar, Rakesh

    2006-01-01

    Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA), reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control. It was observed that leve...

  19. Pulsations of blue supergiants before and after helium core ignition

    OpenAIRE

    Ostrowski, Jakub; Daszyńska-Daszkiewicz

    2013-01-01

    We present results of pulsation analyses of B-type supergiant models with masses of $14 - 18 M_\\odot$, considering evolutionary stages before and after helium core ignition. Using a non-adiabatic pulsation code, we compute instability domains for low degree modes. For selected models in these two evolutionary phases, we compare properties of pulsation modes. Significant differences are found in oscillation spectra and the kinetic energy density of pulsation modes.

  20. Patient Satisfaction Before and After Executing Health Sector Evolution Plan

    OpenAIRE

    Behrouz Hashemi; Alireza Baratloo; Mohammad Mehdi Forouzafar; Maryam Motamedi; Mohammadreza Tarkhorani

    2015-01-01

    Introduction: After long discussions, carrying out health sector evolution (HSE) plan began on May 5, 2014 throughout Iran. Shohadaye Tajrish Hospital, Tehran, was also included in this plan. This study aimed to evaluate the level of emergency department patient satisfaction, before and after running this plan. Methods: This cross-sectional study analyzed the data extracted from a standard questionnaire filled out by the patients presented to the emergency department of Shohadaye Tajrish Hosp...

  1. Effect of low-dose aspirin during pregnancy on fibrinolytic variables before and after parturition

    NARCIS (Netherlands)

    H.A. Bremer (Henk); N. Rotmans (Nel); E.J.Ph. Brommer; H.C.S. Wallenburg (Henk)

    1995-01-01

    textabstractOBJECTIVE: We assessed the effects of a daily oral dose of 60 to 80 mg of aspirin from 12 weeks gestation until delivery on fibrinolytic variables before and after parturition. STUDY DESIGN: In a prospective controlled study labor was electively induced in 24 patients, eight receiving l

  2. Phosphorus Spectroscopy of Calf Muscles before and after Exercise

    OpenAIRE

    Wcisło, Bożena; Cichocka, Monika; Urbanik, Andrzej

    2014-01-01

    Summary Background The aim of this study was to determine 31PMRS reference spectrum and intracellular pH of calf muscles in the dominant limb of healthy, young, male volunteers before and after intense physical effort. Material/Methods Examinations were performed with a 1.5 T MR system. FID CSI (Free Induction Decay Chemical Shift Imaging) sequence was used with the following parameters: TR=4000 ms, FA=90°, NEX=2 and VOI (Volume Of Interest)=8×8×8 cm3 (512 cm3) involving in calf muscles. Raw ...

  3. Evolution of agricultural production of Zaire before and after 1960

    Directory of Open Access Journals (Sweden)

    Sabiti, K.

    1991-01-01

    Full Text Available This study presents the evolution of agricultural production of Zaire before and after 1960 with the help of variable quantifies of products, the cultured area and the exported quantifies of products. A comparative analysis of quantifies of studied products shows that after 1960, the agricultural production of basis foodstuffs of the Zairian population has fallen of the order of 91 % in comparison with the first period. This study shows that the system of peasantry introduced in 1936 by the INEAC, the rationalization of cultural methods connected to the governmental explain the agricultural expansion of Zaire before 1960.

  4. Patient Satisfaction Before and After Executing Health Sector Evolution Plan

    Directory of Open Access Journals (Sweden)

    Behrouz Hashemi

    2015-02-01

    Full Text Available Introduction: After long discussions, carrying out health sector evolution (HSE plan began on May 5, 2014 throughout Iran. Shohadaye Tajrish Hospital, Tehran, was also included in this plan. This study aimed to evaluate the level of emergency department patient satisfaction, before and after running this plan. Methods: This cross-sectional study analyzed the data extracted from a standard questionnaire filled out by the patients presented to the emergency department of Shohadaye Tajrish Hospital over 6-month periods before and after the beginning of HSE. Results: 3665 patients were surveyed. After the execution of the plan, satisfaction decreased significantly regarding pre-discharge training (p = 0.03, hospitalization room condition (p = 0.0002, restroom sanitation (p = 0.007, waiting time to be visited by the physician (p = 0.04, accuracy and duration of physical examination (p = 0.007, feeling confident and desirable outcome (p = 0.03, commitment to religious and moral principles (p = 0.01, and handling financial affairs (p = 0.03. Conclusion: Based on the results of the present study, after execution of HSE plan, patient satisfaction has decreased significantly regarding pre-discharge training, hospitalization room condition, restroom sanitation, timely visit of the physicians, accuracy and duration of physical examination, suggestions for wellbeing of the patient, handling financial affairs, and commitment to religious and moral principles.

  5. A Water Rehabilitation Program in Patients with Hip Osteoarthritis Before and After Total Hip Replacement.

    Science.gov (United States)

    Łyp, Marek; Kaczor, Ryszard; Cabak, Anna; Tederko, Piotr; Włostowska, Ewa; Stanisławska, Iwona; Szypuła, Jan; Tomaszewski, Wiesław

    2016-01-01

    BACKGROUND Pain associated with coxarthrosis, typically occurring in middle-aged and elderly patients, very commonly causes considerable limitation of motor fitness and dependence on pharmacotherapy. This article provides an assessment of a rehabilitation program with tailored water exercises in patients with osteoarthritis before and after total hip replacement. MATERIAL AND METHODS A total of 192 patients (the mean age 61.03±10.89) suffering from hip osteoarthritis (OA) were evaluated before and after total hip replacement (THR). The clinical study covered measurements of hip active ranges of motion (HAROM) and the forces generated by pelvis stabilizer muscles. Pain intensity was assessed according to analogue-visual scale of pain (VAS) and according to the Modified Laitinen Questionnaire. The patients were divided into 6 groups (4 treatment and 2 control). We compared 2 rehabilitation programs using kinesitherapy and low-frequency magnetic field. One of them also had specially designed exercises in the water. Statistical analysis was carried out at the significance level α=0.05. This was a cross-sectional study. RESULTS A positive effect of water exercises on a number of parameters was found in patients with OA both before and after total hip replacement surgery. We noted a significant reduction of pain (ptreatment process (pwater exercises most significantly reduced pain in patients with OA before and after total hip replacement surgery. 2. Inclusion of water exercises in a rehabilitation program can reduce the use of medicines in patient with OA and after THR. PMID:27455419

  6. A Water Rehabilitation Program in Patients with Hip Osteoarthritis Before and After Total Hip Replacement.

    Science.gov (United States)

    Łyp, Marek; Kaczor, Ryszard; Cabak, Anna; Tederko, Piotr; Włostowska, Ewa; Stanisławska, Iwona; Szypuła, Jan; Tomaszewski, Wiesław

    2016-07-25

    BACKGROUND Pain associated with coxarthrosis, typically occurring in middle-aged and elderly patients, very commonly causes considerable limitation of motor fitness and dependence on pharmacotherapy. This article provides an assessment of a rehabilitation program with tailored water exercises in patients with osteoarthritis before and after total hip replacement. MATERIAL AND METHODS A total of 192 patients (the mean age 61.03±10.89) suffering from hip osteoarthritis (OA) were evaluated before and after total hip replacement (THR). The clinical study covered measurements of hip active ranges of motion (HAROM) and the forces generated by pelvis stabilizer muscles. Pain intensity was assessed according to analogue-visual scale of pain (VAS) and according to the Modified Laitinen Questionnaire. The patients were divided into 6 groups (4 treatment and 2 control). We compared 2 rehabilitation programs using kinesitherapy and low-frequency magnetic field. One of them also had specially designed exercises in the water. Statistical analysis was carried out at the significance level α=0.05. This was a cross-sectional study. RESULTS A positive effect of water exercises on a number of parameters was found in patients with OA both before and after total hip replacement surgery. We noted a significant reduction of pain (prehabilitation program including water exercises most significantly reduced pain in patients with OA before and after total hip replacement surgery. 2. Inclusion of water exercises in a rehabilitation program can reduce the use of medicines in patient with OA and after THR.

  7. Stress and marital satisfaction among women before and after their first cycle of in vitro fertilization and intracytoplasmic sperm injection

    NARCIS (Netherlands)

    Verhaak, C.M.; Smeenk, J.M.J.; Eugster, A.; Minnen, A. van; Kremer, J.A.M.; Kraaimaat, F.W.

    2001-01-01

    Objective: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Design: Repeated measurement. Setting: Fertility department at a universi

  8. Stress and marital satisfaction among women before and after their first cycle of in vitro fertilization and intracytoplasmic sperm injection.

    NARCIS (Netherlands)

    Verhaak, C.M.; Smeenk, J.M.J.; Eugster, A.; Minnen, A. van; Kremer, J.A.M.; Kraaimaat, F.W.

    2001-01-01

    OBJECTIVE: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). DESIGN: Repeated measurement. SETTING: Fertility department at a universi

  9. Sexual Function before and after Total Hip Replacement: Narrative Review

    Directory of Open Access Journals (Sweden)

    Rotem Meiri, BPT

    2014-12-01

    Conclusions: The ability to move comfortably is included among the many physical and psychosocial factors influencing sexual functioning. Practitioners should be encouraged to question their THR patients about sexual concerns and to provide counseling related to physical and functional aspects of sexual activity. Rehabilitation that focuses specifically on activities of daily living of sex should include sexual counseling, therapeutic exercise, and advice regarding sexual positions. Rehabilitation provided by physical therapists may help decrease pain, and facilitate greater self‐awareness, self‐confidence, and improved body image, all of which encourage and affirm optimal sexual health. Meiri R, Rosenbaum TY, and Kalichman L. Sexual function before and after total hip replacement: Narrative review. Sex Med 2014;2:159–167.

  10. Multifractal Fluctuations of Jiuzhaigou Tourists Before and after Wenchuan Earthquake

    Science.gov (United States)

    Shi, Kai; Li, Wen-Yong; Liu, Chun-Qiong; Huang, Zheng-Wen

    2013-03-01

    In this work, multifractal methods have been successfully used to characterize the temporal fluctuations of daily Jiuzhai Valley domestic and foreign tourists before and after Wenchuan earthquake in China. We used multifractal detrending moving average method (MF-DMA). It showed that Jiuzhai Valley tourism markets are characterized by long-term memory and multifractal nature in. Moreover, the major sources of multifractality are studied. Based on the concept of sliding window, the time evolutions of the multifractal behavior of domestic and foreign tourists were analyzed and the influence of Wenchuan earthquake on Jiuzhai Valley tourism system dynamics were evaluated quantitatively. The study indicates that the inherent dynamical mechanism of Jiuzhai Valley tourism system has not been fundamentally changed from long views, although Jiuzhai Valley tourism system was seriously affected by the Wenchuan earthquake. Jiuzhai Valley tourism system has the ability to restore to its previous state in the short term.

  11. Balance in Visual Impairment Before and After Intervention Based Games

    Directory of Open Access Journals (Sweden)

    Maria Cecília Moraes Frade

    2014-09-01

    Full Text Available This article’s objective was to evaluate the balance in low vision deficients before and after 16 game therapy sessions. It was approved by the Research Ethics Committee with protocol 2349/2012, and developed at the Institute of the Blind of Central Brazil in Uberaba, Minas Gerais. The sample was made with 10 individuals with low vision in the age group of 12-23 years. Initially, participants were assessed with the Berg Balance Scale, underwent a session of game therapy with Nintendo Wii Fit and then reassessed. After that, 4 of the 10 participants were chosen to conduct 16 sessions of therapy for 2 months. In the end, the balance was reassessed. The results showed significant improvement in balance. The virtual rehabilitation can be used in several kinds of treatments, as it improves motor function, decreases perception of pain and improves balance. We conclude that the game therapy showed balance improvements in the subjects.

  12. Morphometric evaluation of keratocystic odontogenic tumor before and after marsupialization

    Directory of Open Access Journals (Sweden)

    Deborah Campos Telles

    2013-12-01

    Full Text Available The aim of the present study was the morphometric evaluation of the epithelial lining and fibrous capsule in histological specimens of keratocystic odontogenic tumors (KOTs before and after marsupialization. Histological sections from six KOTs that had undergone marsupialization followed by enucleation were photographed. The thickness and features of the capsule and of the epithelial lining of the tumor were evaluated upon marsupialization and upon subsequent enucleation using Axion Vision software. The histological specimens taken upon marsupialization presented an epithelial lining that is typical of KOTs. After marsupialization, the enucleated specimens had a modified epithelial lining and a fibrous capsule that both presented a greater median thickness (p = 0.0277 and p = 0.0212, respectively, morphological changes, and significant enlargement. These modifications can facilitate full surgical treatment and may well be related to a low KOT recurrence rate.

  13. Diarrheal Diseases Hospitalization in Yemen before and after Rotavirus Vaccination.

    Science.gov (United States)

    Amood Al-Kamarany, Mohammed; Al-Areqi, Lina; Mujally, Abulatif; Alkarshy, Fawzya; Nasser, Arwa; Jumaan, Aisha O

    2016-01-01

    The study aims to assess the impact of rotavirus vaccine introduction on diarrheal diseases hospitalization and to identify the rotavirus genotypes most prevalent before and after vaccine introduction among children ≤ 5 years of age. Rotarix™ ® rotavirus vaccine is currently licensed for infants in Yemen and was introduced in 2012. The vaccination course consists of two doses. The first dose is administrated at 6 weeks of age and the second dose is completed by 10 weeks. Based on a longitudinal observational study, we assessed the impact of vaccination on rotavirus hospitalization before and after vaccination among children ≤ 5 years of age at the Yemeni-Swedish Hospital (YSH) in Taiz, Yemen. Prevaccination covered January 2009-July 2012 during which 2335 fecal samples were collected from children ≤ 5 years old. Postvaccination covered January 2013-December 2014 during which 1114 fecal samples were collected. Rotavirus was detected by Enzyme Linkage Immunosorbent Assay (ELISA). The incidence of rotavirus hospitalization decreased from 43.79% in 2009 to 10.54% in 2014. Hospitalization due to rotavirus diarrhea was reduced by 75.93%. Vaccine coverage increased from 23% in 2012 to 72% in 2014. Also, the results showed that the most predominant genotypes in prevaccination period were G2P[4] (55.0%), followed by G1P[8] (15.0%), while in postvaccination period G1P[8] (31%) was the predominant genotype, followed by G9P[8] (27.5%). In conclusion, rotavirus vaccination in Yemen resulted in sharp reduction in diarrheal hospitalization. A successful rotavirus vaccination program in Yemen will rely upon efficient vaccine delivery systems and sustained vaccine efficacy against diverse and evolving rotavirus strains. PMID:27437161

  14. Diarrheal Diseases Hospitalization in Yemen before and after Rotavirus Vaccination

    Directory of Open Access Journals (Sweden)

    Mohammed Amood AL-Kamarany

    2016-01-01

    Full Text Available The study aims to assess the impact of rotavirus vaccine introduction on diarrheal diseases hospitalization and to identify the rotavirus genotypes most prevalent before and after vaccine introduction among children ≤ 5 years of age. Rotarix™ ® rotavirus vaccine is currently licensed for infants in Yemen and was introduced in 2012. The vaccination course consists of two doses. The first dose is administrated at 6 weeks of age and the second dose is completed by 10 weeks. Based on a longitudinal observational study, we assessed the impact of vaccination on rotavirus hospitalization before and after vaccination among children ≤ 5 years of age at the Yemeni-Swedish Hospital (YSH in Taiz, Yemen. Prevaccination covered January 2009–July 2012 during which 2335 fecal samples were collected from children ≤ 5 years old. Postvaccination covered January 2013–December 2014 during which 1114 fecal samples were collected. Rotavirus was detected by Enzyme Linkage Immunosorbent Assay (ELISA. The incidence of rotavirus hospitalization decreased from 43.79% in 2009 to 10.54% in 2014. Hospitalization due to rotavirus diarrhea was reduced by 75.93%. Vaccine coverage increased from 23% in 2012 to 72% in 2014. Also, the results showed that the most predominant genotypes in prevaccination period were G2P[4] (55.0%, followed by G1P[8] (15.0%, while in postvaccination period G1P[8] (31% was the predominant genotype, followed by G9P[8] (27.5%. In conclusion, rotavirus vaccination in Yemen resulted in sharp reduction in diarrheal hospitalization. A successful rotavirus vaccination program in Yemen will rely upon efficient vaccine delivery systems and sustained vaccine efficacy against diverse and evolving rotavirus strains.

  15. Antioxidant status in neonatal jaundice before and after phototherapy

    Directory of Open Access Journals (Sweden)

    S Ayyappan

    2015-01-01

    Full Text Available Background: Neonatal jaundice refers to yellow coloration of the skin and the sclera (whites of the eyes of newborn babies that result from the accumulation of bilirubin in the skin and mucous membranes. Because bilirubin is potentially toxic to the central nervous system. Genetic disorders of bilirubin conjugation, particularly the common Gilbert′s syndrome, can also contribute to neonatal hyperbilirubinemia. Objective: The aim of this study was to evaluate the lipid per-oxidation and antioxidant enzyme activities in patients with neonatal jaundice before and after phototherapy. Materials and Methods: The study includes 50 neonatal jaundice patients with average age 2-15 days. All patients of neonatal jaundice receiving phototherapy except feeding, cleaning. Subjects selected were from the patients attending Pediatrics Department. Plasma malondialdehyde (MDA, erythrocyte glutathione peroxidase (GPX, superoxide dismutase and catalase (CAT to monitor the bilirubin level. Results: The results show increased levels of bilirubin compared with controls (P < 0.001 shows the level of plasma MDA in control, before and after phototherapy. Represents the level of GPX was significantly increased in after the phototherapy group when compared with before phototherapy and control SPSS soft ware: (P < 0.001. Shows the reduced glutathione (GSH level in plasma was significantly decreased in the after phototherapy group when compared with before phototherapy and control (P < 0.001. And finally with ascorbic acid and CAT. Conclusion: It is evident from the study that increased oxidative stress in neonatal jaundice babies leads to decrease in the levels of antioxidants like GSH and ascorbic acid and disturb their metabolism, that weaken their ability to fight the growing stress. Intense oxidative stress and decreased antioxidants may contribute to neural cell death and alter the erythrocytomembrane structure processing in neonatal jaundice.

  16. Effect of low-dose aspirin during pregnancy on fibrinolytic variables before and after parturition

    OpenAIRE

    Bremer, Henk; Rotmans, Nel; Brommer, E.J.Ph.; Wallenburg, Henk

    1995-01-01

    textabstractOBJECTIVE: We assessed the effects of a daily oral dose of 60 to 80 mg of aspirin from 12 weeks gestation until delivery on fibrinolytic variables before and after parturition. STUDY DESIGN: In a prospective controlled study labor was electively induced in 24 patients, eight receiving low-dose aspirin and 16 controls. Levels were determined in maternal and cord plasma of tissue-type plasminogen activator antigen and activity, plasminogen activator inhibitor-1 antigen, plasminogen ...

  17. Computed tomography in low back pain before and after myelography

    International Nuclear Information System (INIS)

    Forty-six patients with possible lumbar disk herniation were examined with computed tomography (CT) before and after lumbar myelography with metrizamide. Altogehter 90 intervertebral spaces (L4/L5 and L5/S1) were analyzed with regard to the diagnostic information provided by pre- and postmyelography CT. Corresponding to the level of 73 intervertebral spaces (81%) the contrast medium filling of the dural sac was homogeneous, while corresponding to 17 spaces (19%) the filling was inhomogeneous, with layering of contrast medium. The demarcation of the disk margin and of the dural sac was poor at the level of 13 spaces (14%), the majority of which (9 spaces) belonged to the group with homogeneous dural sac filling. At the level of 4 intervertebral spaces the dural sac was isodense with the intervertebral disk. The overall diagnostic information from the premyelography examination was equal to the postmyelography examination at 66 intervertebral spaces (73%). The postmyelography CT examination showed the details better than the conventional CT at 11 intervertebral spaces (12%), and poorer than conventional CT at 13 intervertebral spaces (15%). It is concluded that in general a conventional CT examination is adequate in the evaluation of patients with suggested intervertebral disk herniation. The need for a postmyelography CT examination can be specified on the basis of the findings at myelography. (orig.)

  18. Hydro reservoir handling in Norway before and after deregulation

    Energy Technology Data Exchange (ETDEWEB)

    Wolfgang, Ove; Haugstad, Arne; Mo, Birger; Gjelsvik, Anders [SINTEF Energy Research, 7465 Trondheim (Norway); Wangensteen, Ivar; Doorman, Gerard [NTNU, Department of Electric Power Engineering, 7491 Trondheim (Norway)

    2009-10-15

    The Norwegian Energy Act that came into force in 1991 deregulated the electricity market and removed the former obligation power companies had to supply electricity to the geographical area they were responsible for. Hence producers can supply electricity on the basis of profitability. In 2007 the Energy Act was evaluated by the Government. As a part of this, a study concerning hydro reservoir handling before and after deregulation was carried out by SINTEF. Public statistics show that average hydro reservoir levels measured in per cent of reservoir capacity have been reduced after 1990. We have used the power-market model EMPS (EFI's Multi-area Power-market Simulator) to analyze if this reduction can be explained by natural variation in climatic variables or by structural changes that have occurred after 1990. Simulation results show that the reduced reservoir levels cannot be explained by natural variation in climatic variables. Structural changes such as increased transmission capacities can, however, explain some of the reduction. Our study does not indicate that the present reservoir handling gives reservoir levels that are too low. In this paper we also describe the stochastic dynamic optimization problem for long-term hydropower scheduling, and we explain how this problem actually is solved by the EMPS model. (author)

  19. Commercial sexual practices before and after legalization in Australia.

    Science.gov (United States)

    Seib, Charrlotte; Dunne, Michael P; Fischer, Jane; Najman, Jackob M

    2010-08-01

    The nature of sex work changes over time for many reasons. In recent decades around the world, there has been movement toward legalization and control of sex economies. Studies of the possible impact of legalization mainly have focused on sexually transmitted infections and violence, with little attention to change in the diversity of sexual services provided. This study examined the practices of sex workers before and after legalization of prostitution. Cross-sectional surveys of comparable samples of female sex workers were conducted in 1991 (N = 200, aged 16-46 years) and 2003 (N = 247, aged 18-57 years) in Queensland, Australia, spanning a period of major change in regulation of the local industry. In 2003, male clients at brothels and private sole operators (N = 161; aged 19-72 years) were also interviewed. Over time, there was a clear increase in the provision of "exotic" sexual services, including bondage and discipline, submission, fantasy, use of sex toys, golden showers, fisting, and lesbian double acts, while "traditional" services mostly remained at similar levels (with substantial decrease in oral sex without a condom). Based on comparisons of self-reports of clients and workers, the demand for anal intercourse, anal play, and urination during sex apparently exceeded supply, especially in licensed brothels. Within this population, legalization of sex work coincided with a substantial increase in diversity of services, but it appears that in the regulated working environments, clients who prefer high risk practices might not dictate what is available to them.

  20. Oral manifestations of allograft recipients before and after renal transplantation

    Directory of Open Access Journals (Sweden)

    Gita Rezvani

    2014-01-01

    Full Text Available Renal transplantation is considered the best treatment option for patients with end-stage renal disease. In this study, the prevalence of oral lesions was studied in a cohort of renal transplant recipients before and after transplantation. Fifty-nine kidney transplant recipients were examined one week before and four months after transplantation. The information gathered included age, sex, smoking history, duration on dialysis, drugs and their doses. There were 41 males (69.5% and 18 females (30.5% with a mean age of 37 years. Before surgery, two patients had non-specific lesions and two other patients had leukoedema. Following transplantation, 24 patients (40.7% did not have any specific lesion. In six patients, we observed non-specific erythematous lesions (10.2%. Other recorded observations are as follows: Gingival hyperplasia in five patients (8.5%, oral candidiasis of the erythematous type in five patients (8.5%, hairy leukoplakia in four patients (6.8% and leukoedema in seven patients (11.9%. In our study patients, the prevalence of oral lesions increased after transplantation, although it was lower than that reported in other studies. This could be due to the differences in sample size, differences between Iranian race and other races and different pharmaceutical formulation of the drug produced in Iran.

  1. Commercial sexual practices before and after legalization in Australia.

    Science.gov (United States)

    Seib, Charrlotte; Dunne, Michael P; Fischer, Jane; Najman, Jackob M

    2010-08-01

    The nature of sex work changes over time for many reasons. In recent decades around the world, there has been movement toward legalization and control of sex economies. Studies of the possible impact of legalization mainly have focused on sexually transmitted infections and violence, with little attention to change in the diversity of sexual services provided. This study examined the practices of sex workers before and after legalization of prostitution. Cross-sectional surveys of comparable samples of female sex workers were conducted in 1991 (N = 200, aged 16-46 years) and 2003 (N = 247, aged 18-57 years) in Queensland, Australia, spanning a period of major change in regulation of the local industry. In 2003, male clients at brothels and private sole operators (N = 161; aged 19-72 years) were also interviewed. Over time, there was a clear increase in the provision of "exotic" sexual services, including bondage and discipline, submission, fantasy, use of sex toys, golden showers, fisting, and lesbian double acts, while "traditional" services mostly remained at similar levels (with substantial decrease in oral sex without a condom). Based on comparisons of self-reports of clients and workers, the demand for anal intercourse, anal play, and urination during sex apparently exceeded supply, especially in licensed brothels. Within this population, legalization of sex work coincided with a substantial increase in diversity of services, but it appears that in the regulated working environments, clients who prefer high risk practices might not dictate what is available to them. PMID:19115101

  2. A Water Rehabilitation Program in Patients with Hip Osteoarthritis Before and After Total Hip Replacement

    Science.gov (United States)

    Łyp, Marek; Kaczor, Ryszard; Cabak, Anna; Tederko, Piotr; Włostowska, Ewa; Stanisławska, Iwona; Szypuła, Jan; Tomaszewski, Wiesław

    2016-01-01

    Background Pain associated with coxarthrosis, typically occurring in middle-aged and elderly patients, very commonly causes considerable limitation of motor fitness and dependence on pharmacotherapy. This article provides an assessment of a rehabilitation program with tailored water exercises in patients with osteoarthritis before and after total hip replacement. Material/Methods A total of 192 patients (the mean age 61.03±10.89) suffering from hip osteoarthritis (OA) were evaluated before and after total hip replacement (THR). The clinical study covered measurements of hip active ranges of motion (HAROM) and the forces generated by pelvis stabilizer muscles. Pain intensity was assessed according to analogue-visual scale of pain (VAS) and according to the Modified Laitinen Questionnaire. The patients were divided into 6 groups (4 treatment and 2 control). We compared 2 rehabilitation programs using kinesitherapy and low-frequency magnetic field. One of them also had specially designed exercises in the water. Statistical analysis was carried out at the significance level α=0.05. This was a cross-sectional study. Results A positive effect of water exercises on a number of parameters was found in patients with OA both before and after total hip replacement surgery. We noted a significant reduction of pain (pdegree of degenerative deforming lesions and the effects of the treatment process (p<0.01). Conclusions 1. The rehabilitation program including water exercises most significantly reduced pain in patients with OA before and after total hip replacement surgery. 2. Inclusion of water exercises in a rehabilitation program can reduce the use of medicines in patient with OA and after THR. PMID:27455419

  3. The quality of marriage before and after vasectomy.

    Science.gov (United States)

    Howard, G

    1979-09-01

    A randomly selected sample of 145 couples were seen at the time of a vasectomy request and a year or 18 months later, regardless of whether the vasectomy had been performed, to assess the quality of marriage before and after vasectomy. The sample was seen by 10 different doctors and studied in a seminar at the Cassel Hospital, Ham (UK). All doctors had had training in dealing with psychosexual problems. As part of each interview, the marital pattern was assessed using the following scale: 1) joint, warm, reciprocal, rewarding, showing loving concern; 2) fair, strains but a bearable modest success; and 3) real strains, contained but with difficulty; 4) major strains for both and marital war or major apathy; and 5) impending disaster (breakdown, illness, break up, divorce, or other cause). Using this scale, it became apparent that the majority of marriages improved in quality following vasectomy. This was the case in all age groups. It also appeared that the majority of requests came from successful marriages (score 1 and 2), in some of which strains apparent before vasectomy were not observed afterwards. 90% of the youngest age group had only minor strains whereas in the oldest group 56% had minor strains and 44% major difficulties in the marital relationship. The 94 successful marriages showing only minor strain hoped that vasectomy would prevent further pregnancies and would remove the need for contraception. They felt that they had reached the limit of parenthood and must have absolute protection against pregnancy. Following vasectomy, these marriages improved. Minor sexual problems disappeared, and tensions were eased. The exceptions were couples who had colluded; 3 couples were about to separate and hid their problems. 2 couples hid the husband's history of previous depressive illness. Both the men became severely depressed afterwards. The 37 marriages showing difficulties had also hoped that vasectomy would prevent further pregnancies and the need for

  4. Symptoms in Children with Convergence Insufficiency: Before and After Treatment

    Science.gov (United States)

    Barnhardt, Carmen; Cotter, Susan A.; Mitchell, G. Lynn; Scheiman, Mitchell; Kulp, Marjean T.

    2012-01-01

    Purpose To investigate symptom patterns and evaluate the relationship between patient characteristics and symptom severity before and after treatment for symptomatic children with convergence insufficiency (CI). Methods In a randomized clinical trial, the Convergence Insufficiency Symptom Survey (CISS) was administered pre- and post-treatment to 221 children 9 to <18 years with symptomatic CI. Frequency of symptom type was determined at baseline, mean change in performance-related versus eye-related symptoms for treatment responders was compared, and the relationship between patient characteristics and symptom severity at baseline for the entire cohort and after treatment for those who responded to treatment, was determined. Results At baseline, the score for performance-related symptoms was greater than that for eye-related symptoms (mean response of 2.3 vs. 1.8, p<0.001) regardless age, sex, race/ethnicity, or presence of parent-reported ADHD. Symptom severity increased with age for both the overall and eye-related subscale scores (p=0.048, p=0.022, respectively). Children with parent-reported ADHD were more symptomatic (p=0.005) than those without parent-reported ADHD because of a higher performance-related score (p<0.001). A significant and equal improvement (p<0.01) for the performance-related and eye-related symptoms was found in treatment responders. Girls had significantly lower performance-related symptoms than boys (p=0.014) and African-American children reported less eye-related symptoms than White children (p=0.022). Children without parent-reported ADHD had significantly less symptoms overall and less eye-related symptoms than children with parent-reported ADHD (p=0.019, p=0.011, respectively). Conclusions Because of a high frequency of both performance- and eye-related symptoms, clinicians should perform a targeted history that addresses both types of symptoms to help identify children with symptomatic CI. Future study regarding the relationship of CI

  5. Cosmonauts' haemostasis system status before and after space flights

    Science.gov (United States)

    Kuzichkin, Dmitry; Markin, Andrey; Morukov, Boris

    Introduction. It is known that cosmonauts expose themselves to psychophysical effort in different phases of space flights as well as in pre- and post-flight period. Stress affects different body systems functioning changes including haemostasis system. It is shown that adrenalin directly activates XII coagulation cascade factor [McKay D. G., Latour I. G., Parrish M. N.,1970], initiating intrinsic clotting pathway and affects fibrinogen concentration increase in plasma [Zubairov D. M., 1978]. A post-flight increase in the fibrinogen concentration was revealed with its drop up to the pre-flight level within rehabilitation period [T. Peter Stein, Margaret D., 2006]. Stress agents influence on haemostasis system is physiologically determined and directed to body preparation before probable blood loss. One can consider this process as a function of intrinsic clotting pathway. But in case of blood loss absence the preliminary permanent coagulation activation can lead to appearance of thrombosis risk. Purpose. The purpose was to study haemostasis system main components functional activity features before and after space flights. Methods. In the citrated plasma of astronauts who performed short-term (10 to 11 days) or long-term (196 to 199 days) the following values were determined: activated partial thrombin time (APTT); prothrombin time; prothrombin index; international normalized ratio; thrombin time (TT); activity of enzymes influencing the function of proteins involved in the formation and lysis of a clot such as antithrombin III, protein C, plasminogen, antiplasmin; content of fibrinogen, as well as intermediate products of formation and degradation of fibrin such as D-dimer, soluble fibrin-monomer complexes (SFMC). Sampling of biomaterial was perfomed 30 to 45 days prior to the flight, during the 1st day of the post flight period (all the examined persons), and in the 7th and 14th day (long-term flights member only) Results. In pre-flight period cosmonauts’ APTT

  6. Effect of an environmental health educational programme for paediatricians in an Egyptian University Hospital: before and after study

    OpenAIRE

    Abbas, Reem A; Alghobashy, Ashgan A

    2012-01-01

    Objectives To study the effect of an educational intervention on paediatricians' knowledge, attitudes and practices regarding children's environmental health and to identify the sources of information and common environmental history taking constrains. Design Before and after study. Setting Zagazig University Paediatric Hospital. Participants Practising paediatricians from all specialty units. Main outcome measures The outcome of a specifically designed educational programme about paediatric ...

  7. Medication before and after a spinal cord lesion

    DEFF Research Database (Denmark)

    Jensen, Elmo K; Biering-Sørensen, F

    2014-01-01

    OBJECTIVE: To map the impact of spinal cord lesion (SCL) on medication. STUDY DESIGN: Registration of medication for 72 patients before SCL and at discharge from the Department for Spinal Cord Injuries. SETTING: Department for Spinal Cord Injuries, East Denmark. METHODS: The changes in medication...... for each Anatomical Therapeutic Chemical (ATC) Classification System group were registered for all patients, who were discharged from Department for Spinal Cord Injuries during 2010. The changes in medication per se were calculated for different parts of the population: non-traumatic, traumatic patients...... severely injured (AIS A, B and C). The increase in medication may have implications for side effects and for the economy of all involved....

  8. Sun exposure before and after a diagnosis of cutaneous malignant melanoma

    DEFF Research Database (Denmark)

    Idorn, L W; Philipsen, P A; Wulf, H C

    2011-01-01

    Previous studies on ultraviolet radiation (UVR) exposure before and after a diagnosis of cutaneous malignant melanoma (CMM) have been based primarily on questionnaires. Objective measures are needed....

  9. Pelvic organ function before and after laparoscopic bowel resection for rectosigmoid endometriosis

    DEFF Research Database (Denmark)

    Riiskjaer, M; Greisen, S; Glavind-Kristensen, M;

    2016-01-01

    OBJECTIVE: To assess urinary, sexual, and bowel function before and after laparoscopic bowel resection for rectosigmoid endometriosis. DESIGN: Prospectively collected data regarding the function of the pelvic organs. SETTING: Tertiary endometriosis referral unit, Aarhus University Hospital. SAMPLE......: A cohort of 128 patients who underwent laparoscopic bowel resection for endometriosis. METHODS: The International Consultation on Incontinence Questionnaire (ICIQ), Sexual Function-Vaginal Changes Questionnaire (SVQ), and the Low Anterior Resection Syndrome (LARS) questionnaire were answered before.......40; P = 0.002) of increased incontinence problems (I-score) 1 year after surgery. CONCLUSION: A significant and clinically relevant improvement in urinary and sexual function 1 year after laparoscopic bowel resection for endometriosis was found. Except for anastomotic leakage, this could be observed...

  10. 5-HMF and carbohydrates content in stingless bee honey by CE before and after thermal treatment.

    Science.gov (United States)

    Biluca, Fabíola C; Della Betta, Fabiana; de Oliveira, Gabriela Pirassol; Pereira, Lais Morilla; Gonzaga, Luciano Valdemiro; Costa, Ana Carolina Oliveira; Fett, Roseane

    2014-09-15

    This study aimed to assess 5-hydroximethylfurfural and carbohydrates (fructose, glucose, and sucrose) in 13 stingless bee honey samples before and after thermal treatment using a capillary electrophoresis method. The methods were validated for the parameters of linearity, matrix effects, precision, and accuracy. A factorial design was implemented to determine optimal thermal treatment conditions and then verify the postprocedural 5-HMF formation, but once 5-HMF were carbohydrate levels ranged from 48.59% to 69.36%. In the same conditions of thermal treatment, Apis mellifera honey presented higher 5-HMF content than stingless bee honey. Results suggest that a high temperature related to briefer thermal treatment could be an efficient way to extend shelf life without affecting 5-HMF content in stingless bee honey.

  11. Obstructive Sleep Apnea Severity and Overnight Body Fluid Shift before and after Hemodialysis

    Science.gov (United States)

    Forni Ogna, Valentina; Mihalache, Alexandra; Pruijm, Menno; Halabi, Georges; Phan, Olivier; Cornette, Françoise; Bassi, Isabelle; Haba Rubio, José; Burnier, Michel; Heinzer, Raphaël

    2015-01-01

    Background and objectives Obstructive sleep apnea is associated with significantly increased cardiovascular morbidity and mortality. Fluid overload may promote obstructive sleep apnea in patients with ESRD through an overnight fluid shift from the legs to the neck soft tissues. Body fluid shift and severity of obstructive sleep apnea before and after hemodialysis were compared in patients with ESRD. Design, setting, participants, & measurements Seventeen patients with hemodialysis and moderate to severe obstructive sleep apnea were included. Polysomnographies were performed the night before and after hemodialysis to assess obstructive sleep apnea, and bioimpedance was used to measure fluid overload and leg fluid volume. Results The mean overnight rostral fluid shift was 1.27±0.41 L prehemodialysis; it correlated positively with fluid overload volume (r=0.39; P=0.02) and was significantly lower posthemodialysis (0.78±0.38 L; P<0.001). There was no significant difference in the mean obstructive apnea-hypopnea index before and after hemodialysis (46.8±22.0 versus 42.1±18.6 per hour; P=0.21), but obstructive apnea-hypopnea index was significantly lower posthemodialysis (−10.1±10.8 per hour) in the group of 12 patients, with a concomitant reduction of fluid overload compared with participants without change in fluid overload (obstructive apnea-hypopnea index +8.2±16.1 per hour; P<0.01). A lower fluid overload after hemodialysis was significantly correlated (r=0.49; P=0.04) with a lower obstructive apnea-hypopnea index. Fluid overload—assessed by bioimpedance—was the best predictor of the change in obstructive apnea-hypopnea index observed after hemodialysis (standardized r=−0.68; P=0.01) in multivariate regression analysis. Conclusions Fluid overload influences overnight rostral fluid shift and obstructive sleep apnea severity in patients with ESRD undergoing intermittent hemodialysis. Although no benefit of hemodialysis on obstructive sleep apnea severity

  12. Tissue electrical properties in head and neck tumors before and after surgery: Preliminary observations

    Directory of Open Access Journals (Sweden)

    T Malecka-Massalska

    2014-01-01

    Full Text Available Context: Bioelectrical impedance analysis (BIA detects changes in tissue electrical properties and has been seen as a prognostic tool in several chronic conditions, including cancer. AIMS: The study was conducted to investigate whether there are any tissue electrical differences in patients with head and neck cancer (H and NC before and after surgery treatment. Settings and Design: The observational study was performed at the Otolaryngology Department, Head and Neck Oncology. Materials and Methods : Tissue electrical properties were assessed in 31 patients with H and NC before and 2 weeks after surgery treatment. Direct bioimpedance measures [resistance, reactance, phase angle (PA] were determined by BIA. Statistical Analysis Used: The Shapiro-Wilk test was used to assess the distribution conformity of examined parameters with a normal distribution; the Fisher (F test was used to assess variance homogeneity. For group comparisons of metric data we used the Mann-Whitney U test. P value < 0.05 was considered as statistically significant. The statistical analysis for this study was performed using the computer software STATISTICA v. 8.0 (StatSoft. Results: PA at 50 kHz was found to be significantly (P = 0.000009 lower after surgery in patients with H and NC than before treatment (4.69° ±0.71 vs. 4.22 ± 0.83, respectively. Resistance was significantly (P = 0.0005 greater after surgery in patients with H and NC than before (596.24 ± 96.31 ohm vs 647.64 ± 276.11 ohm, respectively. Conclusions: There are tissue electrical differences before and after surgery in patients diagnosed with H and NC. Further observations would be useful to feedback in support therapy planning of individual patients.

  13. The Effects of Vitamin D Supplementation on Pulmonary Function of Chronic Obstructive Pulmonary Disease Patients, before and after Clinical Trial

    OpenAIRE

    Seyed Ali Javad Moosavi; Maryam Haddadzadeh Shoushtari

    2015-01-01

    Vitamin D has several extra calcemic effects. Vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients but little is known about it’s association with lung function. Objective: To investigate whether supplementation with vitamin D could improve pulmonary function in COPD patients. Design: Before and after, double center, clinical trial. Setting: Hazrat Rasoul University Hospital, Tehran, and Imam Khomaini University Hospital, Ahvaz, Iran. Participants:...

  14. Differences of adaptation to school and self-resilience before and after sleep education for adolescent

    OpenAIRE

    Lee, So-Mi; Kim, Jong-Hee

    2016-01-01

    This study aims to verify the effectiveness of sleep education by identifying the differences of adaption to school and self-resilience of the high school students before and after sleep education for a certain period of time. The conclusion of this study is presented below: First, there were differences in adaptation to school and self-resilience of the high school students before and after sleep education for the high school students. After sleep education, adaptation to school environment ...

  15. Coral-Bacterial Communities before and after a Coral Mass Spawning Event on Ningaloo Reef

    OpenAIRE

    Janja Ceh; Jean-Baptiste Raina; Soo, Rochelle M; Mike van Keulen; Bourne, David G.

    2012-01-01

    Bacteria associated with three coral species, Acropora tenuis, Pocillopora damicornis and Tubastrea faulkneri, were assessed before and after coral mass spawning on Ningaloo Reef in Western Australia. Two colonies of each species were sampled before and after the mass spawning event and two additional samples were collected for P. damicornis after planulation. A variable 470 bp region of the 16 S rRNA gene was selected for pyrosequencing to provide an understanding of potential variations in ...

  16. Investigation of Pain in Hip Disease Patients before and after Arthroplasty

    OpenAIRE

    MORIMOTO,Yosuke(Researcher of Graduate School of Kyoto University ); Kondo, Yasutaka; Shimosako, Junpei; Kozu, Ryo; Kataoka, Hideki; Sakamoto, Junya; Nakano, Jiro; Okita, Minoru

    2011-01-01

    [Purpose] This study examined pain in patients with hip disease before and after arthroplasty and whether the pain was induced in the hip joint itself. [Subjects and Methods] Fifty-two patients presenting with hip disease who did not exhibit dementia, disease of the lower limbs or lumbar disease were included in this investigation. Regional pain, the site of maximum pain and Visual Analogue Scale (VAS) of the site of maximum pain before and after arthroplasty were evaluated. [Results] Groin d...

  17. Assessment of preclinical students’ academic motivation before and after a three-day academic affair program

    Directory of Open Access Journals (Sweden)

    Aung MN

    2015-12-01

    Full Text Available Myo Nyein Aung,1 Juraiporn Somboonwong,2 Vorapol Jaroonvanichkul,1 Pongsak Wannakrairot3 1Medical Education Unit, 2Quality Management Division and Department of Physiology, 3Academic Affairs Division, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandBackground: Medical students’ motivation is an important driving factor for academic performance, and therefore medical teachers and educators are often highly interested in this topic. This study evaluated the impact of an academic affair program upon preclinical year medical students’ motivation to study.Design and methods: An intervention study was conducted using a pretest-posttest study design. A total of 296 preclinical year medical students who had just passed their first year and were about to attend their second year at the Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, participated in the study. The intervention comprised of dialogues for personality development, pictorial expression in groups, as well as small group lectures delivered by senior students giving information on how to prepare for the forthcoming classes. Students’ academic motivation was measured before and after the intervention program, applying the transculturally translated Academic Motivation Scale (AMS. Cronbach’s alpha of Thai version AMS was 0.8992. The average scores in seven scales of AMS were compared between the pre- and posttest results, using the Wilcoxon signed-rank test. The differences were confirmed by using the multivariate analysis of variance.Results: Students’ academic motivation increased after participation in the three-day academic program. There was also a significant increase in introjected extrinsic motivation, which can enhance the students’ self-esteem and feeling of self-worth (P<0.001. Moreover, intrinsic motivation toward accomplishment increased significantly (P<0.001. This is related to the enjoyment of passing academic milestones, and a step

  18. Assessment of preclinical students’ academic motivation before and after a three-day academic affair program

    Science.gov (United States)

    Aung, Myo Nyein; Somboonwong, Juraiporn; Jaroonvanichkul, Vorapol; Wannakrairot, Pongsak

    2015-01-01

    Background Medical students’ motivation is an important driving factor for academic performance, and therefore medical teachers and educators are often highly interested in this topic. This study evaluated the impact of an academic affair program upon preclinical year medical students’ motivation to study. Design and methods An intervention study was conducted using a pretest-posttest study design. A total of 296 preclinical year medical students who had just passed their first year and were about to attend their second year at the Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, participated in the study. The intervention comprised of dialogues for personality development, pictorial expression in groups, as well as small group lectures delivered by senior students giving information on how to prepare for the forthcoming classes. Students’ academic motivation was measured before and after the intervention program, applying the transculturally translated Academic Motivation Scale (AMS). Cronbach’s alpha of Thai version AMS was 0.8992. The average scores in seven scales of AMS were compared between the pre- and posttest results, using the Wilcoxon signed-rank test. The differences were confirmed by using the multivariate analysis of variance. Results Students’ academic motivation increased after participation in the three-day academic program. There was also a significant increase in introjected extrinsic motivation, which can enhance the students’ self-esteem and feeling of self-worth (Pmotivation toward accomplishment increased significantly (Pacademic milestones, and a step ahead of autonomous motivation. Amotivation level declined significantly (Pacademic motivational constructs before and after the intervention was altogether significant (P=0.036, multivariate analysis of variance). Conclusion After experiencing a three-day intervention, the new students’ motivation advanced along the continuum of self-determination toward

  19. CHEMICAL AND ENERGETIC CONTENT OF CORN BEFORE AND AFTER PRE-CLEANING

    Directory of Open Access Journals (Sweden)

    Sandra Iara Furtado Costa Rodrigues

    2015-04-01

    Full Text Available The poultry industry normally has little control over the raw material that arrives at the processing plant. This experiment aimed to evaluate chemical and energetic quality of corn obtained in a feed mill before and after pre-cleaning. Twenty samples of 30 kg of corn each were taken from trucks delivering corn to the mill. The trucks were then unloaded and the material passed through a pre-cleaning process when another sample was taken. Samples were graded and physical properties evaluated: density (g/L, grain percentages of foreign material, impurities, fragments, broken, soft, insect damaged, fire-burnt, fermented, damaged, cracked and fine particles, as well as chemical composition analysis: Apparent metabolizable energy for poultry (AME, ether extract (EE, crude fiber (CF, starch (STA, water activity (WA, crude protein (CP, digestible and total lysine, methionine, cystine, threonine, tryptophan, valine, isoleucine, leucine, phenylalanine, histidine and arginine. The experiment was a randomized design with two treatments (before and after pre-cleaning and twenty replications. Data was analyzed using SAS ® and treatment differences obtained using F test. Correlations and principal components were calculated. There was a decrease in density after the pre-cleaning process, which was probably due to the removal of earth and stones rather than grain and its fractions. Significant increases were found for insect damage, fermented and damaged grain while fire-burn was significantly reduced after the pre-cleaning process. Starch increased after pre-cleaning which is a result of contaminants that normally are poor in this carbohydrate, but fiber levels increased too. Apparent metabolizable energy, aminoacids, digestible (P<0.05 and total (P<0.05 histidine, total lysine and methionine (P<0.1 levels were reduced after pre-cleaning. Density was higher when there were fewer impurities such as straw, husk or small grains. Broken corn was positively

  20. Electronic and Optical Properties of Aluminum Oxide Before and After Surface Reduction by Ar+ Bombardment

    Directory of Open Access Journals (Sweden)

    D. Tahir

    2014-08-01

    Full Text Available The electronic and optical properties of a-Al2O3 after induced by 3-keV Ar+ sputtering have been studied quantitatively by use of reflection electron energy loss spectroscopy (REELS spectra. The band gap values of a-Al2O3 was determined from the onset values of the energy loss spectrum to the background level of REELS spectra as a function of time Ar+ bombardment. The bandgap changes from 8.4 eV before sputtering to 6.2 eV after 4 minutes of sputtering.The optical properties of α-Al2O3 thin films have been determined by comparing the experimental cross section obtained from reflection electron energy loss spectroscopy with the theoretical inelastic scattering cross section, deduced from the simulated energy loss function (ELF by using QUEELS-ε(k-REELS software. The peak assignments are based on ELF and compared with reported data on the electronic structure of α-Al2O3 obtained using different techniques. The results demonstrate that the electronic and optical properties before and after surface reduction will provide further understanding in the fundamental properties of α-Al2O3 which will be useful in the design, modeling and analysis of devices applications performance.

  1. The E-assessment burger: Supporting the Before and After in E-Assessment Systems

    Directory of Open Access Journals (Sweden)

    Anne Adams

    2015-08-01

    Full Text Available This paper describes a threshold concept-driven e-assessment system that supports teachers in writing effective formative multiple-choice questions, creating quizzes tailored to students’ learning pathways. The system, which has been co-designed with teachers, acts as the ‘bun’ on either side of an ‘e-assessment burger’ pedagogically scaffolding quiz creation (the top of the bun, integrating the quiz within personalized learning trajectories (the burger and feeding the results back to the learners and teachers to guide the direction of future learning pathways (the bottom of the bun. The evaluation with 26 students in 3 subjects across two schools identified that supporting the before and after e-assessment empowers a shift in teachers’ encouragement for student ownership of assessment, guiding their learning pathways. Teachers also provide insights into how the system scaffolding and visualisations inspired changes to sequencing learning and teaching practices. In conclusion the changing role of assessment within a school ecosystem is debated.

  2. Immunostimulatory effects of extract of Pulicaria crispa before and after Schistosoma mansoni infection.

    Science.gov (United States)

    Maghraby, Amany S; Shalaby, Nagwa; Abd-Alla, Howida I; Ahmed, Samia A; Khaled, Hussein M; Bahgat, Mahmoud M

    2010-01-01

    The immunostimulatory effects of methanolic extract from Pulicaria crispa were investigated in mice before and after infection with Schistosoma mansoni. Mice were subjected for daily intra-peritoneal injection by the extract (33 ng/mouse) for 10 successive days followed by infecting every mouse with 100 S. mansoni cercariae. Treatment with the extract induced significant increase (p < 0.05) in sera-IL-2 before and after infection. Upon using soluble worm antigen preparation or cancer bladder homogenates as antigens in ELISA, the detected levels of IgG were significantly (p < 0.05) higher in sera from treated-infected mice than untreated P. crispa infected mice. Using crude Escherichia coli lysate as an antigen in ELISA, it was detected a significant (p < 0.05) increase in IgG levels in sera from the extract-treated mice before and after infection.

  3. Energy consumption and indoor climate in a residential building before and after comprehensive energy retrofitting

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Rose, Jørgen; Christen Mørck, Ove;

    2016-01-01

    before and after the retrofit. In three of the flats in Traneparken measurements of ventilation conditions were performed using passive tracer gas technique together with continuous registration of the room air temperature, the relative humidity and the CO2-concentration using programmable data loggers....... including new facades, new windows, additional insulation, mechanical ventilation with heat recovery and a photovoltaic installation on the roof. The measured energy consumption for heating and domestic hot water before and after renovation was 139.1 kWh/m2/year and 95.6 kWh/m2/year respectively...

  4. Exercise-induced increase in dog adipose tissue blood flow before and after denervation

    DEFF Research Database (Denmark)

    Bülow, J; Madsen, J

    1986-01-01

    Subcutaneous adipose tissue blood flow was examined during rest and exercise in the inguinal fat pads of four female dogs using the Xe wash-out technique. The experiments were performed before and after denervation of one of the pads. No difference between the resting flows in the two pads could...... be demonstrated either before or after denervation. The flow increased about two-fold on average from rest to exercise. This response was similar before and after denervation. It is concluded that direct sympathetic innervation is not involved in the regulation of adipose tissue blood flow during exercise....

  5. Blood levels of organochlorines before and after chemotherapy among non-Hodgkin's lymphoma patients.

    Science.gov (United States)

    Baris, D; Kwak, L W; Rothman, N; Wilson, W; Manns, A; Tarone, R E; Hartge, P

    2000-02-01

    Several small studies suggest a link between environmental exposure to organochlorine compounds and risk of non Hodgkin's lymphoma (NHL). Because NHL is uncommon, studies of the topic often use a population-based case-control design, in which cases generally are enrolled after treatment has begun. If chemotherapy affects blood levels of organochlorines, exposure will be misclassified and findings distorted. To determine whether chemotherapy alters serum levels of organochlorines in NHL cases, we compared serum samples before and after treatment in 22 cases diagnosed with NHL between March 1994 and August 1995 and enrolled in a clinical trial at the United States National Cancer Institute's Clinical Center. The time difference between pretreatment and posttreatment samples ranged from 15 to 27 months with an average of 20 months. Laboratory analyses were conducted in blinded pretreatment and posttreatment pairs of the subjects. Pretreatment and posttreatment organochlorine serum levels were compared using Pearson correlation coefficient (r) and paired t test. The pretreatment and posttreatment serum levels were highly correlated for 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and polychlorinated biphenyls (PCBs) PCB-138, PCB-153, PCB-156, and total PCBs (ranging from 0.78 to 0.93). Serum levels of all of these organochlorines significantly decreased between initiation and completion of chemotherapy, 25% for total PCB (P = 0.0044), 28% for DDE (P = 0.0014), 25% for PCB-138 (P = 0.0053), 27% for PCB-153 (P = 0.0031), and 29% for PCB-156 (P = 0.045). Neither weight change nor lipid change was correlated with changes in chemical levels. There was no association between the length of time between blood draws and changes in chemical levels. Our data raise the possibility that lymphoma treatment depresses serum organochlorine levels. PMID:10698481

  6. Requests for euthanasia in general practice before and after implementation of the Dutch Euthanasia Act

    Science.gov (United States)

    van Alphen, Jojanneke E; Donker, Gé A; Marquet, Richard L

    2010-01-01

    Background The Netherlands was the first country in the world to implement a Euthanasia Act in 2002. It is unknown whether legalising euthanasia under strict conditions influences the number and nature of euthanasia requests. Aim To investigate changes in the number of, and reasons for, requests for euthanasia in Dutch general practice after implementation of the Euthanasia Act. Design of study Retrospective dynamic cohort study comparing 5 years before (1998–2002) and 5 years after (2003–2007) implementation of the Act. Method Standardised registration forms were used to collect data on requests for euthanasia via the Dutch Sentinel Practice Network. This network of 45 general practices is nationally representative by age, sex, geographic distribution, and population density. Results The mean annual incidence of requests before implementation amounted to 3.1/10 000 and thereafter to 2.8/10 000 patients. However, trends differed by sex. The number of requests by males decreased significantly from 3.7/10 000 to 2.6/10 000 (P = 0.008); the requests by females increased non-significantly from 2.6/10 000 to 3.1/10 000. Before and after implementation, cancer remained the major underlying disease for requesting euthanasia: 82% versus 77% for men; 73% versus 75% for females. Pain was a major reason for a request, increasing in the period before implementation (mean 27%), but declining in the period thereafter (mean 22%). Loss of dignity became a less important reason after implementation (from 18% to 10%, P = 0.04), predominantly due to a marked decrease in the number of females citing it as a reason (from 17% to 6%, P = 0.02). Conclusion There was no increase in demand for euthanasia after implementation of the Euthanasia Act. Pain as a reason for requesting euthanasia showed an increasing trend before implementation, but declined thereafter. Loss of dignity as a reason declined, especially in females. PMID:20353671

  7. How to Make Sense of Temporal/Spatial "Before" and "After."

    Science.gov (United States)

    Feagans, Lynne

    1980-01-01

    Studies the perceptual relationship between temporal "before" and "after" and their spatial counterparts. Adults reported temporal "before" related to spatial "after" and temporal "after" related to spatial "before." Three-year old children better understood spatial "after" and spatial "before," suggesting a temporal/spatial semantic acquisition…

  8. Physical functioning before and after total hip arthroplasty : Perception and performance

    NARCIS (Netherlands)

    van den Akker-Scheek, Inge; Zijlstra, Wiebren; Groothoff, Johan W.; Bulstra, Sjoerd K.; Stevens, Martin

    2008-01-01

    Background and Purpose. Self-report and performance-based measures of physical functioning in people before and after total hip arthroplasty seem to present different information. The relationship between these different measures is not well understood, and little information is available about chan

  9. Following an HIV Regimen: Steps to Take Before and After Starting HIV Medicines

    Science.gov (United States)

    HIV Treatment Following an HIV Regimen: Steps to Take Before and After Starting HIV Medicines (Last updated 3/1/2016; last reviewed 3/1/2016) ... maintain long-term medication adherence. Before starting an HIV regimen, talk to your health care provider about ...

  10. Dynamics of the aorta before and after endovascular aneurysm repair: a systematic review.

    NARCIS (Netherlands)

    Keulen, J.W. van; Prehn, J. van; Prokop, M.; Moll, F.L.; Herwaarden, J.A. van

    2009-01-01

    OBJECTIVE: An overview of the knowledge of thoracic (TAA), and abdominal aortic aneurysm (AAA) dynamics, before and after endovascular repair, is given. METHODS: Medline, EMBASE and the Cochrane database were searched for relevant articles. After inclusion and exclusion, 25 relevant articles reporti

  11. Dynamics of the Aorta Before and After Endovascular Aneurysm Repair : A Systematic Review

    NARCIS (Netherlands)

    van Keulen, J. W.; van Prehn, J.; Prokop, M.; Moll, F. L.; van Herwaarden, J. A.

    2009-01-01

    Objective: An overview of the knowledge of thoracic (TAA), and abdominal aortic aneurysm (AAA) dynamics, before and after endovascular repair, is given. Methods: Medline, EMBASE and the Cochrane database were searched for relevant articles. After inclusion and exclusion, 25 relevant articles reporti

  12. Imaging of Gastrointestinal Stromal Tumors before and after Imatinib Mesylate Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Shankar, S.; Dundamadappa, S.K.; Karam, A.R. (Radiology Dept., Univ. of Massachusetts Medical Center, Worcester, MA (United States)); Stay, R.M. (Radiology Dept., Univ. of Virginia, Charlottesville, VA (United States)); Sonnenberg, E. van (Radiology Dept., Dana Farber Cancer Inst., Boston, MA (United States))

    2009-10-15

    Gastrointestinal stromal tumors (GISTs) account for the majority of gastrointestinal mesenchymal tumors. Recent advances in treatment using the molecular targeting agent imatinib mesylate have shown startling response rates and variegated imaging findings. We present the various imaging appearances of GIST on computed tomography (CT) and magnetic resonance imaging (MRI), both before and after treatment.

  13. Energy consumption and indoor climate in a residential building before and after comprehensive energy retrofitting

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Rose, Jørgen; Christen Mørck, Ove;

    2016-01-01

    including new facades, new windows, additional insulation, mechanical ventilation with heat recovery and a photovoltaic installation on the roof. The measured energy consumption for heating and domestic hot water before and after renovation was 139.1 kWh/m2/year and 95.6 kWh/m2/year respectively, and...

  14. Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations

    OpenAIRE

    Gesquiere, Ina; Darwich, Adam S; Van der Schueren, Bart; de Hoon, Jan; Lannoo, Matthias; Matthys, Christophe; Rostami, Amin; Foulon, Veerle; Augustijns, Patrick

    2015-01-01

    The aim of the present study was to evaluate the disposition of metoprolol after oral administration of an immediate and controlled-release formulation before and after Roux-en-Y gastric bypass (RYGB) surgery in the same individuals and to validate a physiologically based pharmacokinetic (PBPK) model for predicting oral bioavailability following RYGB.

  15. Trends in Community Pharmacy Counts and Closures before and after the Implementation of Medicare Part D

    Science.gov (United States)

    Klepser, Donald G.; Xu, Liyan; Ullrich, Fred; Mueller, Keith J.

    2011-01-01

    Purpose: Medicare Part D provided 3.4 million American seniors with prescription drug insurance. It may also have had an unintended effect on pharmacy viability. This study compares trends in the number of pharmacies and rate of pharmacy closures before and after the implementation of Medicare Part D. Methods: This retrospective observational…

  16. Television Entertainment Shows in Romania before and after the Revolution Moment in 1989

    OpenAIRE

    Calinciuc, Iulia Andreea

    2013-01-01

    A comparative analysis of the television entertainment shows before and after the revolution moment in 1989, focusing on the messages transmitted, as well as the type of entertainment, censorship, values and relationships between the technical and artistic teams at the Romanian public television (TVR)

  17. Use of symptom-relieving drugs before and after surgery for urinary incontinence in women

    DEFF Research Database (Denmark)

    Sørensen, Rikke Guldberg; Brostrøm, Søren; Kesmodel, Ulrik Schiøler;

    2013-01-01

    To describe the use of symptom-relieving drugs (antimuscarinic drugs or duloxetine) before and after surgery for urinary incontinence (UI); and for those with use of antimuscarinic drugs or duloxetine before surgery, to estimate the risk of being a postoperative user, relative to those without use...

  18. Peer Review in Higher Education: Student Perceptions before and after Participation

    Science.gov (United States)

    Mulder, Raoul A.; Pearce, Jon M.; Baik, Chi

    2014-01-01

    Peer review is integral to academic endeavour, but opportunities for students to benefit from peer review in higher education remain limited, and relatively little is known about how student perceptions influence their appreciation of peer review. University student perceptions were examined before and after experiencing student peer review in…

  19. MITOCHONDRIAL DYNAMICS IN PRE- AND POSTPUBERTAL PIG OOCYTES BEFORE AND AFTER IN VITRO MATURATION

    DEFF Research Database (Denmark)

    Pedersen, H. S.; Løvendahl, P.; Nikolaisen, N. K.;

    2013-01-01

    Oocytes from prepubertal (PRE) or postpubertal (POST) pigs are used in, for example, somatic cell nuclear transfer and in vitro fertilization. Here we describe mitochondrial dynamics in pig oocytes of different sizes before and after in vitro maturation (IVM), isolated from PRE or POST animals...

  20. Effects of outdoor temperature on changes in physiological variables before and after lunch in healthy women

    Science.gov (United States)

    Okada, Masahiro; Kakehashi, Masayuki

    2014-03-01

    Previous studies of autonomic nervous system responses before and after eating when controlling patient conditions and room temperature have provided inconsistent results. We hypothesized that several physiological parameters reflecting autonomic activity are affected by outdoor temperature before and after a meal. We measured the following physiological variables before and after a fixed meal in 53 healthy Japanese women: skin temperature, systolic and diastolic blood pressure, salivary amylase, blood glucose, heart rate, and heart rate variability. We assessed satiety before and after lunch using a visual analog scale (100 mm). We recorded outdoor temperature, atmospheric pressure, and relative humidity. Skin temperature rose significantly 1 h after eating (greater in cold weather) (P = 0.008). Cold weather markedly influenced changes in diastolic blood pressure before (P = 0.017) and after lunch (P = 0.013). Fasting salivary amylase activity increased significantly in cold weather but fell significantly after lunch (significantly greater in cold weather) (P = 0.007). Salivary amylase was significantly associated with cold weather, low atmospheric pressure, and low relative humidity 30 min after lunch (P metabolism.

  1. The focus parameters and their correlation from small earthquakes before and after the 1995 Douhe earthquake

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Based on seismic source spectrum solution by multi-station and multi-event coda method, applying Brune seismic source model, we have got the source factors and spectra of 48 small earthquakes occurred before and after the Douhe earthquake of October 6 in 1995. The seismic moments, corner frequencies and stress drops are estimated from the spectra, and their correlation and variation with time before and after the Douhe earthquake are discussed. The results indicate that the source factors show good stability, their peak frequencies and variation with frequency appear quite similar. Some events with higher stress drops occurred about one year before the Douhe earthquake. Taking into the account that the stress drop is calculated from seismic moment and frequency, as well as the correlation between them, we emphasis that the higher stress drop mentioned here just implies the higher corner frequency than the normal value.

  2. Clinical effect and necessity of interventional treatment in diabetic foot before and after amputation

    International Nuclear Information System (INIS)

    Objective: To assess the clinical effect and necessity of interventional treatment in diabetic foot before and after amputation. Methods: Combined intravascular angioplasty with intraarterial medicine perfusing were carried out in fourteen patients with diabetic foot including 10 patients treated before amputation and 4 after amputation involving superficial femoral, deep femoral, tibial and fitular arteries. Among them seventeen vessels with irregular stenosis and obstruction were treated by intravascular angioplasty through balloon dilation. Results: The technical successful rate was 100%, no complication happened. The symptoms were relieved in all patients after treatment, including promotion of lower extremity arterial blood perfusion, reducing range of amputation and wound healing after amputation. Conclusions: Intravascular interventional treatment is safe, effective and valuable in diabetic foot before and after amputation. (authors)

  3. Evaluation of quality of life before and after videothoracoscopic simpathectomy for primary hyperhidrosis

    Directory of Open Access Journals (Sweden)

    João Batista Baroncello

    2014-10-01

    Full Text Available Objective: To assess quality of life before and after thoracoscopic sympathectomy for treatment of primary hyperhidrosis. Methods: we conducted an observational, analytical, cross-sectional and quantitative study. We evaluated patients undergoing thoracoscopic sympathectomy for primary axillary hyperhidrosis, primary palmar hyperhidrosis, and axillary hyperhidrosis associated with palmar one. We applied a questionnaire on quality of life related to hyperhidrosis before and after the operation. Results: The questionnaire was administered to 51 patients with a mean age of 32.4 years, 45 women and six men. The average quality of life related to hyperhidrosis in a score of 0-100 before sympathectomy was 34.6 and after the operation it was 77.1. Compensatory hyperhidrosis occurred in 84.3% of patients. Conclusion: thoracoscopic sympathectomy improves the quality of life of patients with primary hyperhidrosis, with results supported over time. Compensatory hyperhidrosis occurred in most patients, but did not significantly influence the improved quality of life.

  4. Statistical processing of natality data for the Czech Republic before and after the Chernobyl accident

    International Nuclear Information System (INIS)

    All available data regarding natality in Czechoslovakia (or the Czech Republic) before and after the Chernobyl accident are summarized. Data from the databases of the Czech Statistical Office and of the State Office for Nuclear Safety were used to analyze natality and mortality of children in the Czech Republic and to evaluate the relationship between the level of contamination and the change in the sex ratio at time of birth that was observed in some areas in November of 1986. Although the change in the ratio of newborn boys-to-girls ratio was statistically significant, no direct relationship between that ratio and the level of contamination was found. Statistically significant changes in the sex ratio also occurred in Czechoslovakia (or in the Czech Republic) in the past, both before and after the accident. Furthermore, no statistically significant changes in the rate of stillbirths and multiple pregnancies were observed after the Chernobyl accident

  5. On the stability of preferences and attitudes before and after experiencing an electric vehicle

    DEFF Research Database (Denmark)

    Jensen, Anders Fjendbo; Cherchi, Elisabetta; Mabit, Stefan Lindhard

    2013-01-01

    after a real experience with an electric vehicle in the household. In particular, there are major changes in the preference for driving range, top speed, fuel cost, battery life and charging in city centres and train stations. In line with other studies, we find that environmental concern has a positive......In this study, we investigate the extent to which experience affects individual preferences for specific electric vehicle characteristics, individual attitudes toward the environment, and the impact of the attitudes on the choice between an electric and a conventional vehicle. We use a two......-wave stated preference experiment where data was collected before and after the respondents experienced an electric vehicle for three months. We estimate a hybrid choice model using jointly the stated choices before and after the test period. The results show that individual preferences change significantly...

  6. Zinc status before and after zinc supplementation of eating disorder patients.

    Science.gov (United States)

    McClain, C J; Stuart, M A; Vivian, B; McClain, M; Talwalker, R; Snelling, L; Humphries, L

    1992-12-01

    Reduced food consumption is a major manifestation of zinc (Zn) deficiency. Many manifestations of Zn deficiency are complications of anorexia nervosa and bulimia nervosa. We evaluated serum and 24-hour urinary Zn values in 12 healthy volunteers and 33 eating disorder patients before and after hospitalization which included either Zn supplementation (75 mg Zn/day) or placebo. Bulimics had depressed serum Zn concentrations (p deficiency may act as a "sustaining" factor for abnormal eating behavior in certain eating disorder patients. PMID:1460184

  7. Biological hazard evaluation of a pharmaceutical effluent before and after a photo-Fenton treatment.

    Science.gov (United States)

    Novoa-Luna, Karen Adriana; Mendoza-Zepeda, Arisbeht; Natividad, Reyna; Romero, Rubi; Galar-Martínez, Marcela; Gómez-Oliván, Leobardo Manuel

    2016-11-01

    The aim of this study was to evaluate the biological hazard of a pharmaceutical effluent before and after treatment. For the former, the determined 96h-LC50 value was 1.2%. The photo-Fenton treatment catalyzed with an iron-pillared clay reduced this parameter by 341.7%. Statistically significant increases with respect to the control group (PPCT, oxidative stress, genotoxic damage and LC50 in Hyalella azteca. PMID:27392336

  8. In vivo P-glycoprotein function before and after epilepsy surgery

    OpenAIRE

    Bauer, Martin; Karch, Rudolf; Zeitlinger, Markus; Liu, Joan; Koepp, Matthias J.; Asselin, Marie-Claude; Sisodiya, Sanjay M; Hainfellner, Johannes A; Wadsak, Wolfgang; Mitterhauser, Markus; Müller, Markus; Pataraia, Ekaterina; Langer, Oliver

    2014-01-01

    Objectives: To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[11C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function. Methods: Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patient...

  9. Effect of transparency on changing views regarding nuclear energy before and after Fukushima accident

    OpenAIRE

    YAMAMURA, Eiji

    2011-01-01

    Using cross-country data, this paper examines the influence of government transparency on changing views regarding nuclear energy before and after Japan’s natural and nuclear disasters of 2011. It was observed that in the majority of countries the rate of favoring nuclear energy declined after the disaster. However, empirical results have shown that this rate is less likely to decrease in a more transparent country, even after a disaster. This implies that views regarding nuclear energy were ...

  10. A comparison before and after lamotrigine use in long term continuation treatment: effect of blood level

    OpenAIRE

    Kesebir, Sermin; Akdeniz, Fisun; Demir, Aysun; Bilici, Mustafa

    2013-01-01

    Objective: The hypothesis of this study is that the efficacy of lamotrigine is related with blood level in bipolar disorder. Our aim is to compare the periods before and after lamotrigine use in cases with bipolar disorder and to investigate whether there has been any relation between lamotrigine blood level and clinical progress or not. Method: For this aim, 40 consecutive cases diagnosed with bipolar disorder type I according to DSM-IV criteria, using lamotrigine for at least two years i...

  11. Cognitive performance before and after the onset of subjective cognitive decline in old age

    OpenAIRE

    Koppara, Alexander; Wagner, Michael; Lange, Carolin; Ernst, Annette; Wiese, Birgitt; König, Hans-Helmut; Brettschneider, Christian; Riedel-Heller, Steffi; Luppa, Melanie; Weyerer, Siegfried; Werle, Jochen; Bickel, Horst; Mösch, Edelgard; Pentzek, Michael; Fuchs, Angela

    2015-01-01

    Background Our objectives were (1) to test the association between the report of subjective cognitive decline (SCD) and prospective objective cognitive performance in high age individuals and (2) to study the course of longitudinal cognitive performance before and after the first report of SCD. Methods Cognitively normal elderly participants of the German Study on Ageing, Cognition, and Dementia study (N = 2330) with SCD (subjective decline in memory with and without associated concerns) and ...

  12. Airway response to inhaled salbutamol in hyperthyroid and hypothyroid patients before and after treatment.

    OpenAIRE

    Harrison, R N; Tattersfield, A. E.

    1984-01-01

    For many years the development of thyrotoxicosis has been known to cause a deterioration in asthma but the mechanism is unknown. We have studied the effect of thyroid function on airway beta adrenergic responsiveness in 10 hyperthyroid and six hypothyroid subjects before and after treatment of their thyroid disease. Airway adrenergic responsiveness was assessed by measuring specific airway conductance (sGaw) after increasing doses of inhaled salbutamol (10-410 micrograms). After treatment the...

  13. Determination of element composition in CoffeeBricks before and after incineration

    OpenAIRE

    Fröling, Annika

    2015-01-01

    The purpose for this study was to determine the element composition in CoffeeBricks before and after incineration. The difference between element composition in CoffeeBricks (barbecue briquettes made out of spent coffee grounds) and regular barbecue briquettes was also evaluated in this study. Aqua regia digests from the ash residues of CoffeeBricks and the ash residues of regular barbecue briquettes were analyzed with Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). H2SO4/H...

  14. Pulmonary alveolar proteinosis in a child: HRCT findings before and after bronchoalveolar lavage

    International Nuclear Information System (INIS)

    We demonstrate the high-resolution computed tomography (HRCT) findings of pulmonary alveolar proteinosis in a child before and after bronchoalveolar lavage. The CT pattern in our case differs from the pattern described in previous reports. We found a more homogeneous distribution of the pulmonary changes and a ''crazy paving'' pattern. High-resolution CT may be helpful in the differential diagnosis of this rare disease and in the follow-up of the pulmonary changes after bronchoalveolar lavage. (orig.)

  15. Nociception Before and After Exercise In Rats Bred for High and Low Aerobic Capacity

    OpenAIRE

    Geisser, Michael E; Wang, Wenfei; Smuck, Matthew; Koch, Lauren G.; Britton, Steven L.; Lydic, Ralph

    2008-01-01

    Exercise and stress are known to influence pain perception. However, little is known about how level of fitness influences pain perception and the experience of pain. In the present study, pain perception before and after exercise to exhaustion was examined in 6 rats systematically bred to have a high aerobic capacity (HCR animals) and 6 rats systematically bred to have a low aerobic capacity (LCR animals). HCR animals had significantly higher pain thresholds compared to LCR animals before an...

  16. Evaluation of physiological parameters before and after respiratory physiotherapy in newborns with acute viral bronchiolitis

    OpenAIRE

    S Gonçalves, Rodrigo A; Feitosa, Sérgio; de Castro Selestrin, Cláudia; Vitor E. Valenti; de Sousa, Fernando H; F Siqueira, Arnaldo A; Petenusso, Márcio; de Abreu, Luiz Carlos

    2014-01-01

    Background Acute viral bronchiolitis is a respiratory disease with high morbidity that affects newborn in the first two years of life. Its treatment with physiotherapy has been highlighted as an important tool, however, there is no consensus regarding its effects on patients improvement. We aimed to evaluate the physiological parameters before and after the procedure respiratory therapy in newborn with acute viral bronchiolitis. Method This was a cross sectional observational study in 30 newb...

  17. Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.

    Directory of Open Access Journals (Sweden)

    Winfried Möller

    Full Text Available OBJECTIVES: Chronic rhinosinusitis (CRS is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high. This study investigates the delivery efficiency of a pulsating aerosol in comparison to a nasal pump spray to the sinuses and the nose in healthy volunteers and in CRS patients before and after sinus surgery. METHODS: (99mTc-DTPA pulsating aerosols were applied in eleven CRSsNP patients without nasal polyps before and after sinus surgery. In addition, pulsating aerosols were studied in comparison to nasal pump sprays in eleven healthy volunteers. Total nasal and frontal, maxillary and sphenoidal sinus aerosol deposition and lung penetration were assessed by anterior and lateral planar gamma camera imaging. RESULTS: In healthy volunteers nasal pump sprays resulted in 100% nasal, non-significant sinus and lung deposition, while pulsating aerosols resulted 61.3+/-8.6% nasal deposition and 38.7% exit the other nostril. 9.7+/-2.0 % of the nasal dose penetrated into maxillary and sphenoidal sinuses. In CRS patients, total nasal deposition was 56.7+/-13.3% and 46.7+/-12.7% before and after sinus surgery, respectively (p<0.01. Accordingly, maxillary and sphenoidal sinus deposition was 4.8+/-2.2% and 8.2+/-3.8% of the nasal dose (p<0.01. Neither in healthy volunteers nor in CRS patients there was significant dose in the frontal sinuses. CONCLUSION: In contrast to nasal pump sprays, pulsating aerosols can deliver significant doses into posterior nasal spaces and paranasal sinuses, providing alternative therapy options before and after sinus surgery. Patients with chronic lung diseases based on clearance dysfunction may also benefit from pulsating aerosols, since these diseases also manifest in the upper airways.

  18. Thermographic Imaging of the Superficial Temperature in Racing Greyhounds before and after the Race

    OpenAIRE

    Mari Vainionpää; Esa-Pekka Tienhaara; Marja Raekallio; Jouni Junnila; Marjatta Snellman; Outi Vainio

    2012-01-01

    A total of 47 racing greyhounds were enrolled in this study on two race days (in July and September, resp.) at a racetrack. Twelve of the dogs participated in the study on both days. Thermographic images were taken before and after each race. From the images, superficial temperature points of selected sites (tendo calcaneus, musculus gastrocnemius, musculus gracilis, and musculus biceps femoris portio caudalis) were taken and used to investigate the differences in superficial temperatures bef...

  19. Biological hazard evaluation of a pharmaceutical effluent before and after a photo-Fenton treatment.

    Science.gov (United States)

    Novoa-Luna, Karen Adriana; Mendoza-Zepeda, Arisbeht; Natividad, Reyna; Romero, Rubi; Galar-Martínez, Marcela; Gómez-Oliván, Leobardo Manuel

    2016-11-01

    The aim of this study was to evaluate the biological hazard of a pharmaceutical effluent before and after treatment. For the former, the determined 96h-LC50 value was 1.2%. The photo-Fenton treatment catalyzed with an iron-pillared clay reduced this parameter by 341.7%. Statistically significant increases with respect to the control group (Pphoto-Fenton process decreases the presence of PCT, oxidative stress, genotoxic damage and LC50 in Hyalella azteca.

  20. Iranian Medical Students’ Perception of Psychiatry: Before and After a Psychiatry Clerkship

    OpenAIRE

    Homayoun Amini; Ali-Akbar Nejatisafa; Saeed Shoar; Hosein Kaviani; Mehdi Samimi-Ardestani; Amir Shabani; Sara Esmaeili; Yasaman Moghaddam

    2013-01-01

    Objective We aimed to compare the medical students’ attitude towards psychiatry before and after psychiatry clerkship, and to examine the association of choosing psychiatry as a future career with some personal characteristics. Method In a self-controlled, quasi-experimental study, all of the medical students entering the psychiatry clerkship in three major medical schools of Iran located in Tehran (Tehran, Shahid Beheshti, and Iran University of Medical Sciences) were asked to participate an...

  1. Pulmonary function before and after anterior spinal surgery in adult idiopathic scoliosis.

    OpenAIRE

    Wong, C. A.; Cole, A. A.; L. Watson; Webb, J K; Johnston, I. D.; Kinnear, W. J.

    1996-01-01

    BACKGROUND: Little is known about the long term effects of anterior spinal surgery on pulmonary function in adult patients with idiopathic scoliosis. A study was therefore undertaken of pulmonary function before and after anterior spinal surgery in this group of patients. METHODS: Fourteen patients (12 women) of mean age 26.5 years (range 17-50, 10 > or = 20 years) were studied. All 14 patients underwent thoracotomy and anterior arthrodesis, and five also underwent posterior arthrodesis. Scol...

  2. CHEMICAL AND ENERGETIC CONTENT OF CORN BEFORE AND AFTER PRE-CLEANING

    OpenAIRE

    Sandra Iara Furtado Costa Rodrigues; José Henrique Stringhini; Márcio Ceccantini; Antonio Mário Penz Júnior; Andrea Machado Leal Ribeiro; Vanessa Peripolli; Concepta Margaret McManus Pimentel

    2015-01-01

    The poultry industry normally has little control over the raw material that arrives at the processing plant. This experiment aimed to evaluate chemical and energetic quality of corn obtained in a feed mill before and after pre-cleaning. Twenty samples of 30 kg of corn each were taken from trucks delivering corn to the mill. The trucks were then unloaded and the material passed through a pre-cleaning process when another sample was taken. Samples were graded and physical properties evaluated: ...

  3. Diffusion-weighted MR imaging of salivary glands with gustatory stimulation - Comparison before and after radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yunyan; Gu, Yajia; Peng, Weijun; Mao, Jian; Lei, Yue; Shen, Xigang [Dept. of Radiology, Fudan Univ. Shanghai Cancer Center, Shanghai (China); Dept. of Oncology, Shanghai Medical College, Fudan Univ., Shanghai (China); Ou, Dan; He, Xiayun [Dept. of Radiation Oncology, Fudan Univ. Shanghai Cancer Center, Shanghai (China); Dept. of Oncology, Shanghai Medical College, Fudan Univ., Shanghai (China)

    2013-10-15

    Background: Xerostomia is the most prominent complication in patients with head and neck carcinoma after radiotherapy (RT). Diffusion-weighted magnetic resonance imaging (DWI) with gustatory stimulation may contribute to the evaluation of salivary gland function. Purpose: To investigate the value of DWI for quantifying physiological changes of the parotid gland during gustatory stimulation in patients before and after RT. Material and Methods: Magnetic resonance imaging (MRI) was performed in 28 consecutive patients with nasopharyngeal carcinoma before and after RT and clinical xerostomia was also assessed. A DWI sequence was performed once at rest and continually repeated seven times during stimulation with ascorbic acid. Apparent diffusion coefficient (ADC) maps for parotid glands at different time points and the range of increase with stimulation were calculated. Paired two-tailed Student t tests were used to compare the ADC values before and after stimulation, and before and after RT. Results: Before RT, the ADC showed an initial increase (P<0.001) and then fluctuated during stimulation. After RT, as the clinical xerostomia changed from Grade 0 to Grade 2, the mean ADC at rest increased compared with the pre-RT value (P<0.001). A similar response to stimulation was observed, but the range of increase between the maximum ADC during stimulation and the baseline value at rest was higher post-RT than pre-RT (P=0.022). The minimum ADC during stimulation was higher than the baseline value post-RT (P=0.028), but there was no difference pre-RT (P=0.603). Conclusion: DWI combined with gustatory stimulation seems to display the physiological changes of the parotid gland following RT and may be a potential tool for non-invasively assessing salivary gland function.

  4. Optical performance of the TBC-2 solar collector before and after the 1993 mirror lustering

    Energy Technology Data Exchange (ETDEWEB)

    Houser, R.; Strachan, J. [Sandia National Labs., Albuquerque, NM (United States). Solar Thermal Test Dept.

    1995-02-01

    In 1993, the mirror facets of one of Sandia`s point-focusing solar collectors, the Test Bed Concentrator {number_sign}2 (TBC-2), were reconditioned. The concentrator`s optical performance was evaluated before and after this operation. This report summarizes and compares the results of these tests. The tests demonstrated that the concentrator`s total power and peak flux were increased while the overall flux distribution in the focal plane remained qualitatively the same.

  5. The relationship between serum vitamin A and breast cancer staging before and after radiotherapy

    OpenAIRE

    Andréa Matos; Carla Nogueira; Carlos Franca; Antônio Carvalho; Sérgio Lannes Vieira; Antônio Penna; Andréa Ramalho

    2014-01-01

    Introduction: Several adverse effects of radiotherapy have been associated with the process of increased oxidative stress in the organism. In this context, vitamin A noteworthy for its important role in combating oxidative stress, in addition to its chemoprotective effect. Objective: To assess the serum levels of vitamin A (retinol and β-carotene) and their relationship to breast cancer staging in patients before and after radiotherapy. Methods: This is a prospective study of women with breas...

  6. [Variations of IR-spectra of three coating materials before and after spraying on urea fertilizer].

    Science.gov (United States)

    Liu, Xing-bin; Chen, Li-jun; Wu, Zhi-jie; Zhang, Guang-na

    2009-09-01

    Coated fertilizer is a hot spot in the domain of fertilizer research. Related researches mainly focused on the action mechanisms of coating materials in controlling the nutrient release from coated fertilizers, but less information is available on the structural variation of the coating materials before and after spraying on fertilizers, which is the key to whether we can directly use coating materials to extrapolate its mechanisms in controlling coated fertilizers' nutrient release. With polylactic acid (PLA), poly (butynelenes succinate) (PBS), and polycarbonate (PC) as test materials, the variations of their IR spectra before and after spraying on urea fertilizer were determined, which was aimed to supply theoretical basis for further studying the action mechanisms of coating materials in controlling coated fertilizers nutrient release. The results showed that PLA and PC had less variation in their IR spectra before and after spraying on urea fertilizer, while PBS acted in reverse, suggesting that the former two coating materials could be directly used for studying the patterns of nutrient release from coated fertilizers.

  7. Differences of adaptation to school and self-resilience before and after sleep education for adolescent.

    Science.gov (United States)

    Lee, So-Mi; Kim, Jong-Hee

    2016-06-01

    This study aims to verify the effectiveness of sleep education by identifying the differences of adaption to school and self-resilience of the high school students before and after sleep education for a certain period of time. The conclusion of this study is presented below: First, there were differences in adaptation to school and self-resilience of the high school students before and after sleep education for the high school students. After sleep education, adaptation to school environment and school friends became higher, and also the emotion control, personal relations and optimism, which are the subvariables of self-resilience, became higher. Second, there were differences in adaptation to school and self-resilience before and after sleep education by grade of the high school students. The freshmen's adaptation to school friends and adaptation to school life, which are the subvariables of adaptation to school, increased after sleep education. The sophomores' adaptation to school environment, which is the subvariable of adaptation to school, went up higher after sleep education. The freshmen's emotion control, vitality and personal relations, which are the subvariables of self-resilience, were higher after sleep education. The sophomores' personal relations, which are a subvariable of self-resilience, went up higher.

  8. [Variations of IR-spectra of three coating materials before and after spraying on urea fertilizer].

    Science.gov (United States)

    Liu, Xing-bin; Chen, Li-jun; Wu, Zhi-jie; Zhang, Guang-na

    2009-09-01

    Coated fertilizer is a hot spot in the domain of fertilizer research. Related researches mainly focused on the action mechanisms of coating materials in controlling the nutrient release from coated fertilizers, but less information is available on the structural variation of the coating materials before and after spraying on fertilizers, which is the key to whether we can directly use coating materials to extrapolate its mechanisms in controlling coated fertilizers' nutrient release. With polylactic acid (PLA), poly (butynelenes succinate) (PBS), and polycarbonate (PC) as test materials, the variations of their IR spectra before and after spraying on urea fertilizer were determined, which was aimed to supply theoretical basis for further studying the action mechanisms of coating materials in controlling coated fertilizers nutrient release. The results showed that PLA and PC had less variation in their IR spectra before and after spraying on urea fertilizer, while PBS acted in reverse, suggesting that the former two coating materials could be directly used for studying the patterns of nutrient release from coated fertilizers. PMID:19950629

  9. Non-verbal auditory cognition in patients with temporal epilepsy before and after anterior temporal lobectomy

    Directory of Open Access Journals (Sweden)

    Aurélie Bidet-Caulet

    2009-11-01

    Full Text Available For patients with pharmaco-resistant temporal epilepsy, unilateral anterior temporal lobectomy (ATL - i.e. the surgical resection of the hippocampus, the amygdala, the temporal pole and the most anterior part of the temporal gyri - is an efficient treatment. There is growing evidence that anterior regions of the temporal lobe are involved in the integration and short-term memorization of object-related sound properties. However, non-verbal auditory processing in patients with temporal lobe epilepsy (TLE has raised little attention. To assess non-verbal auditory cognition in patients with temporal epilepsy both before and after unilateral ATL, we developed a set of non-verbal auditory tests, including environmental sounds. We could evaluate auditory semantic identification, acoustic and object-related short-term memory, and sound extraction from a sound mixture. The performances of 26 TLE patients before and/or after ATL were compared to those of 18 healthy subjects. Patients before and after ATL were found to present with similar deficits in pitch retention, and in identification and short-term memorisation of environmental sounds, whereas not being impaired in basic acoustic processing compared to healthy subjects. It is most likely that the deficits observed before and after ATL are related to epileptic neuropathological processes. Therefore, in patients with drug-resistant TLE, ATL seems to significantly improve seizure control without producing additional auditory deficits.

  10. Acoustical analysis of trained and untrained singers onsite before and after prolonged voice use

    Science.gov (United States)

    Jackson, Christophe E.

    Controlled acoustic environments are important in voice research. Recording environment affects the quality of voice recordings. While sound booths and anechoic chambers are examples of controlled acoustic environments widely used in research, they are both costly and not portable. The long-term goal of this project is to compare the voice usage and efficiency of trained and untrained singers onsite immediately before and after vocal performance. The specific goal of this project is the further of development a Portable Sound Booth (PSB) and standardization of onsite voice recording procedures under controlled conditions. We hypothesized that the simple and controlled acoustic environment provided by the PSB would enable consistent reliable onsite voice recordings and the immediate differences as a consequence of voice usage were measurable. Research has suggested that it would be possible to conduct onsite voice recordings. Proof of concept research titled "Construction and Characterization of a Portable Sound Booth for Onsite Measurement" was conducted before initiating the full research effort. Preliminary findings revealed that: (1) it was possible to make high-quality voice recordings onsite, (2) the use of a Portable Sound Booth (PSB) required further acoustic characterization of its inherent acoustic properties, and (3) testable differences before and after performance were evident. The specific aims were to (1) develop and refine onsite objective voice measurements in the PSB and (2) evaluate use of the PSB to measure voice quality changes before and after voice usage.

  11. Significance of assess the iron reserves of severe renal anemia patients before and after blood transfusion

    Institute of Scientific and Technical Information of China (English)

    Gui-Fen Zhang

    2015-01-01

    Objective:To study the significance of evaluating hemoglobin and iron reserves in the severe renal anemia patient before and after blood transfusion, to guide clinical treatment.Methods:Simple randomly selected 120 patients in phase 5 of chronic renal failure from the department of nephrology, who are regular dialysis with severe renal anemia, according to the situation of iron reserves before blood transfusion, patients will be divided into its reserves of iron deficiency and iron overload group and normal group, and the three groups were divided into 1 U and 2 U group. Comparing the change of different unit quantity of hemoglobin, serum iron, iron, protein and total iron binding force before and after blood transfusion and variation is compared between groups.Results: Three groups of patients with 1U blood transfusion ,Hemoglobin, serum iron and ferritin, total iron binding force, transferrin saturation are higher before a blood transfusion,The differences were statistically significant; before and after blood transfusion hemoglobin, serum iron and ferritin, total iron binding force, transferrin saturation change in 1 U group normal iron reserves compared with Insufficient iron reserves 1 U group has no statistically significant difference, iron overload 1 U group before and after blood transfusion hemoglobin, serum iron and ferritin, total iron binding force, transferrin saturation change significantly greater than Insufficient iron reserves 1 U group and 1U with normal iron reserves group, the differences were statistically significant; Three groups of patients blood transfusion after 2 U, hemoglobin, serum iron and ferritin, total iron binding force, transferrin saturation were higher before a blood transfusion, differences were statistically significant; iron overload 2 U group before and after blood transfusion hemoglobin, serum iron and ferritin, total iron binding force, transferrin saturation change significantly greater than Insufficient iron reserves 2

  12. Urinary Ghrelin Concentration in Children With Urinary Tract Infections Before and After Treatment

    Directory of Open Access Journals (Sweden)

    Sharifian

    2016-03-01

    Full Text Available Background Urinary tract infections (UTIs are common in children. They can lead to hypertension and end stage renal disease (ESRD. Ghrelin is a regulatory hormone that maintains fat tissues and body composition. Ghrelin is mainly produced in the stomach and in smaller amounts in kidneys. It stimulates release of growth hormone (GH, increases food intake, and causes weight gain. Objectives The aim of this study was to examine weather urinary Ghrelin concentration is involved in anorexia in patients with UTI and its urinary concentration changes with treatment. Patients and Methods This study was performed on 40 hospitalized children with UTI at Mofid children’s hospital during years 2013 to 2014. Ghrelin and Creatinine were measured before and after treatment. statistical analyzes were performed using the SPSS software version 18 by student t test, Wilcoxon test and Spearman coefficient and differences were considered as significant if P < 0.05. Results Mean age was 4.5 ± 3.8 years and 34 (85% were females; 14 children (35% had proteinuria, nine patients (29% had Vesicoureteral Reflux (VUR, eight (20% scare, five (12.5% hydronephrosis and 33 (82.5% anorexia. Mean urinary acylated Ghrelin before and after treatment were 138.4 ± 70.9 and 147.2 ± 72.6, respectively (P < 0.001. There was no significant difference between mean urinary Ghrelin before and after treatment in children with UTI with or without anorexia. Acylated Ghrelin had a direct correlation with the incidence of renal scarring (r = 0.37, P = 0.034. Conclusions Urinary Ghrelin concentration was lower before treatment of UTI and significantly increased after cessation of inflammation. Further studies are required for more definite results.

  13. Comparison of Bolton’s Ratios before and after Treatment in an Iranian Population

    Science.gov (United States)

    Ebadifar, Asghar; Taliee, Rojin

    2013-01-01

    Background and aims The correct relationship of the total mesiodistal width of the mandibular teeth to that of the maxillary teeth (Bolton’s ratios) is among the main factors considered in obtaining an optimal occlusion. The present study was conducted to determining the Bolton’s ratios before and after treatment in skeletal class I patients. Materials and methods In this descriptive analytical study, 200 study casts of 100 patients (including 73 females and 27 males) were selected from 1,700 patient files with fixed, non-extraction orthodontic treatment protocol. The greatest mesiodistal width of teeth was measured using a digital caliper. The total Bolton index (TBI) and anterior Bolton index (ABI) were calculated for subjects and the obtained results were compared with the values reported by Bolton using one-sample t-test. The alterations in these indexes before and after treatment were compared with paired t-test. Results Post-treatment ABI and TBI in patients were 77.35% ± 4.12% and 91.2% ± 1.66%, respectively. No significant difference was detected in ABI and TBI of patients after treatment when compared with the results of Bolton’s study (P > 0.05). However, a significant correlation was observed in values of ABI (P < 0.001) and TBI (P < 0.01) before and after treatment. Conclusion These findings suggest that patients with mild hypodontia have narrower teeth than normal subjects espe-cially in posterior segments, which may have clinical implications during the orthodontic treatment process. PMID:23487005

  14. Relationship Between Vertical Jump Height and Swimming Start Performance Before and After an Altitude Training Camp.

    Science.gov (United States)

    García-Ramos, Amador; Padial, Paulino; de la Fuente, Blanca; Argüelles-Cienfuegos, Javier; Bonitch-Góngora, Juan; Feriche, Belén

    2016-06-01

    García-Ramos, A, Padial, P, de la Fuente, B, Argüelles-Cienfuegos, J, Bonitch-Góngora, J, and Feriche, B. Relationship between vertical jump height and swimming start performance before and after an altitude training camp. J Strength Cond Res 30(6): 1638-1645, 2016-This study aimed (a) to analyze the development in the squat jump height and swimming start performance after an altitude training camp, (b) to correlate the jump height and swimming start performance before and after the altitude training period, and (c) to correlate the percent change in the squat jump height with the percent change in swimming start performance. Fifteen elite male swimmers from the Spanish Junior National Team (17.1 ± 0.8 years) were tested before and after a 17-day training camp at moderate altitude. The height reached in the squat jump exercise with additional loads of 0, 25, 50, 75, and 100% of swimmers' pretest body weight and swimming start performance (time to 5, 10, and 15 m) were the dependent variables analyzed. Significant increases in the jump height (p ≤ 0.05; effect size [ES]: 0.35-0.48) and swimming start performance (p jump height before training (r = -0.56 to -0.77) and after training (r = -0.50 to -0.71). The change in the squat jump height was inversely correlated with the change in the start time at 5 m (r = -0.47), 10 m (r = -0.73), and 15 m (r = -0.62). These results suggest that altitude training can be suitable to enhance explosive performance. The correlations obtained between the squat jump height and start time in the raw and change scores confirm the relevance of having high levels of lower-body muscular power to optimize swimming start performance.

  15. Psychological evaluation of patients with a thyroid nodule before and after surgical treatment

    Directory of Open Access Journals (Sweden)

    Čaparević Zorica

    2002-01-01

    Full Text Available Introduction Association between endocrine and mental disorders has been recognized a long time ago, as well as their mutual dependence. The aim of this study was to evaluate the psychological structure of patients with thyroid nodule before and after surgical treatment. Material and methods In order to establish the type and degree of psychological disorders, we have examined 60 patients with thyroid nodule before and after surgical treatment by using DSM-IV classification of mental disorders and psychological instruments: semi structured psychiatric interview, MMPI, Zung Depression Scale and a list of panic symptoms. Patients with nonautonomous ("cold" nodules presented as euthyroid, and those with autonomous ("hot" nodules (after a period of drug therapy if they were hyperthyroid, required surgery. After a period of drug therapy two groups of patients were compared: group 1- euthyroid with "cold" nodules and group 2 - euthyroid with "hot" nodules. Before surgical treatment both groups under went psychological evaluation. Group 2 presented with: anxiety, depression and panic disorder with or without agoraphobia (72%, 46%, 28% while group 1 presented with following results: 48%, 23%, 14% respectively. After surgical treatment patients from group 1 presented with psychologic disorders in less than 1%. Discussion and conclusion In some physical disorders, psychologic factors contribute directly or indirectly to the etiology, in others, psychologic symptoms are the direct results of a lesion affecting neural or endocrine organs. One of the key etiological factors is often a short-time or long-time stress and its direct consequence is altered functioning of various hormonal systems. Unexpected high percentage of psychological disorders in patients with thyroid disorders suggests that psychological evaluation before and after surgical treatment is unavoidable for good assessment and choice of treatment. These patients need psychotherapeutic and

  16. Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq

    Directory of Open Access Journals (Sweden)

    Park Kyung-Do

    2012-09-01

    Full Text Available Abstract Background Thoroughbred horses are the most expensive domestic animals, and their running ability and knowledge about their muscle-related diseases are important in animal genetics. While the horse reference genome is available, there has been no large-scale functional annotation of the genome using expressed genes derived from transcriptomes. Results We present a large-scale analysis of whole transcriptome data. We sequenced the whole mRNA from the blood and muscle tissues of six thoroughbred horses before and after exercise. By comparing current genome annotations, we identified 32,361 unigene clusters spanning 51.83 Mb that contained 11,933 (36.87% annotated genes. More than 60% (20,428 of the unigene clusters did not match any current equine gene model. We also identified 189,973 single nucleotide variations (SNVs from the sequences aligned against the horse reference genome. Most SNVs (171,558 SNVs; 90.31% were novel when compared with over 1.1 million equine SNPs from two SNP databases. Using differential expression analysis, we further identified a number of exercise-regulated genes: 62 up-regulated and 80 down-regulated genes in the blood, and 878 up-regulated and 285 down-regulated genes in the muscle. Six of 28 previously-known exercise-related genes were over-expressed in the muscle after exercise. Among the differentially expressed genes, there were 91 transcription factor-encoding genes, which included 56 functionally unknown transcription factor candidates that are probably associated with an early regulatory exercise mechanism. In addition, we found interesting RNA expression patterns where different alternative splicing forms of the same gene showed reversed expressions before and after exercising. Conclusion The first sequencing-based horse transcriptome data, extensive analyses results, deferentially expressed genes before and after exercise, and candidate genes that are related to the exercise are provided in this

  17. Iranian Medical Students’ Perception of Psychiatry: Before and After a Psychiatry Clerkship

    Directory of Open Access Journals (Sweden)

    Homayoun Amini

    2013-03-01

    Full Text Available Objective: We aimed to compare the medical students’ attitude towards psychiatry before and after psychiatry clerkship, and to examine the association of choosing psychiatry as a future career with some personal characteristics.Method: In a self-controlled, quasi-experimental study, all of the medical students entering the psychiatry clerkship in three major medical schools of Iran located in Tehran (Tehran, Shahid Beheshti, and Iran University of Medical Sciences were asked to participate anonymously in the study on the first and the last 3-days of their psychiatry clerkship. From 346 invited 4th-5th year medical students, 225 (65% completed anonymous self-report questionnaires before and after a 4-week psychiatry clerkship.Results: Positive response to choose psychiatry as a career was seen in 13.3 % and 18.3 % before and after psychiatry rotation, respectively. However, the difference was not statistically significant; about one-quarter of the students were turned on to psychiatry and 25% were discouraged during the clerkship. Individual pair wise comparisons revealed significant improvements only in two out of 13 measured aspects of psychiatry. Seventeen out of 38 (47.7% students who identified psychiatry as the career of choice or strong possibility reported that one of their family members or close friends’ mental illness had an impact on their choice. Those students who considered psychiatry as the strong possibility claimed that they are more interested in humanities (OR = 2.96; 95% CI: 1.17, 7.49, and playing a musical instrument (OR = 2.53; 95% CI: 1.15, 5.57.Conclusion: It may be concluded that exposure to psychiatry clerkship could influence medical students’ opinion about psychiatry positively, or negatively. Personal characteristics and individual interests of students may play an important role in choosing psychiatry as their future

  18. Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment

    Directory of Open Access Journals (Sweden)

    Cavaleriu Bogdan D.

    2015-01-01

    Full Text Available The aim of this study was to investigate antioxidant enzyme activities and lipid peroxidation levels after systemic corticoid therapy (Solu-Medrol, 250mg/day, for 7 days. The effects of corticoid treatment on superoxide dismutase (SOD and glutathione peroxidase (GPX activity were investigated. Fifteen patients diagnosed with sudden sensorineural hearing loss were enrolled. Serum markers of oxidative stress were measured using spectrophotometric methods. In ten cases, the SOD and GPX activities and malondialdehyde (MDA serum levels before and after corticoid treatment were investigated. Corticoid treatment enhanced antioxidant activity by increasing SOD and GPX activities and decreasing MDA serum levels.

  19. Dynamics of the radioecological situation in Kiev before and after the disaster on Chernobyl NPP

    International Nuclear Information System (INIS)

    The results of long standing observations of radioecological situation in Kiev, which were carried out from the beginning of 60-th and till today in 12 selected points of control are presented in this work. The dynamics of changes of main radiation situation parameters before and after Chernobyl disaster was investigated: the γ-exposure dose rate; the activity of global precipitations, atmosphere sediments and settling dust; radioactive pollution of soil and vegetation. The comparison of the radioecological situations in Kiev and dose loads due to internal and external irradiation for Kiev population in 1985 and 1992 was carried out

  20. The Market Reaction Around Ex-Dates of Stock Splits Before and After Decimalization

    OpenAIRE

    Robin K. Chou; Wan-Chen Lee; Sheng-Syan Chen

    2005-01-01

    This paper examines the stock price behavior around the ex-split dates both before and after the decimalization on the New York Stock Exchange (NYSE). We find that the abnormal ex-split day returns decrease and the abnormal trading volume increases in the 1/16th and decimal pricing eras, relative to the 1/8th pricing era. These findings are consistent with the microstructure-based explanations for the ex-day price movements. Our study also supports the hypothesis that short-term traders perfo...

  1. Change of risk information disclosure in annual report. Before and after earthquake disaster

    International Nuclear Information System (INIS)

    This research examines how risk information disclosure is changing in annual report before and after East Japan Great Earthquake Disaster. Company voluntary disclose risk information in annual report. Manager can decide a style and items of risk information. This paper explores risk information disclosures of Tokyo Electric Power Company, Chubu Power Electric Company, Kansai Electric Power Company and Toyota Motor Corporation. The managers except Tokyo Electric Company are likely to disclose own catastrophe risk before the disaster. However, they do not try to reduce their risk. Corporations' risk information do not link with own risk management. (author)

  2. Macroeconomical development of Czech Republic before and after accession to the European Union

    OpenAIRE

    DOHNAL, Jaroslav

    2011-01-01

    The diploma work deals with development, analysing and assessment of the Czech economy in the years between 2000 and 2010, with a year 2004 as a turning point. Therefore it provides an overview of macroeconomic development before and after the accession of the Czech Republic to the European Union. A conclusion of the work is dedicated to a macroeconomic prediction and its evaluation in a short-term view. Main means of the evaluation are year-on-year figures changes of macroeconomic indica...

  3. Pulmonary alveolar proteinosis in a child: HRCT findings before and after bronchoalveolar lavage

    Energy Technology Data Exchange (ETDEWEB)

    Zontsich, T.; Helbich, T.H.; Herold, C.J. [Department of Radiology, University of Vienna (Austria); Wojnarovsky, C.; Eichler, I. [Department of Pediatrics, University of Vienna (Austria)

    1998-12-01

    We demonstrate the high-resolution computed tomography (HRCT) findings of pulmonary alveolar proteinosis in a child before and after bronchoalveolar lavage. The CT pattern in our case differs from the pattern described in previous reports. We found a more homogeneous distribution of the pulmonary changes and a ``crazy paving`` pattern. High-resolution CT may be helpful in the differential diagnosis of this rare disease and in the follow-up of the pulmonary changes after bronchoalveolar lavage. (orig.) With 1 fig., 9 refs.

  4. [OPEN FIELD BEHAVIOR AS A PREDICTIVE CRITERIA REFLECTING RATS CORTICOSTERONELEVEL BEFORE AND AFTER STRESS].

    Science.gov (United States)

    Umriukhin, P E; Grigorchuk, O S

    2015-12-01

    In the presented study we investigated the possibility to use the open field behavior data for prediction of corticosterone level in rat blood plasma before and after stress. It is shown that the most reliable open field behavior parameters, reflecting high probability of significant upregulation of corticosterone after 3 hours of immobilization, are the short latency of first movement and low locomotor activity during the test. Rats with high corticosterone at normal non-stress conditions are characterized by low locomotor activity and on the contrary long latency period for the entrance of open field center.

  5. Comparison of tritium concentration in rainwater and atmosphere around TNPS before and after commercial service

    International Nuclear Information System (INIS)

    Monitoring results of tritium concentration in the rainwater and atmosphere around Tianwan Nuclear Power Station (TNPS) are introduced, and relevant factors influencing tritium concentration are analyzed. Before and after TNPS commercial service, the result shows that tritium concentration in the rainwater and atmosphere around TNPS rises from background level to twice background level or so and there is not obviously change beyond ten kilometers. Relative factors influencing tritium concentration in the rainwater and atmosphere mainly include gas tritium discharge, the distance to discharge point, the direction and frequency of wind, and amount of precipitation. (author)

  6. Importance of Proprioceptive Information for Postural Control in Children with Strabismus before and after Strabismus Surgery

    Science.gov (United States)

    Bucci, Maria P.; Soufi, Hayette; Villeneuve, Philippe; Colleville, Lucile; Bui-Quoc, Emmanuel; Lions, Cynthia

    2016-01-01

    The objective of this study is to examine the role of proprioception in postural balance in children with strabismus before and after realignment of their visual axes by eye surgery. Postural recordings were made with the TechnoConcept® force platform in 23 children. Several conditions were studied, whether the subjects had both eyes open, or either the dominant or the non-dominant eye open, without and with foam pads of 4 mm underfoot. Recordings were performed before and after strabismus surgery. The surface area, the length and the mean speed of the center of pressure (CoP) were analyzed. Before strabismus surgery, all children showed better stability with both eyes open with respect to the condition with the non-dominant eye open; furthermore postural stability improved in the presence of foam pads. After surgery, the surface area of CoP decreased significantly, especially in the non-dominant eye viewing condition. We suggest that strabismic children use mainly proprioceptive information in order to control their posture, but also visual inputs, which are important for obtaining a good postural stability. The alignment of the visual axes after surgery provides enhanced postural stability, suggesting, again the major role of visual inputs in the control of posture. Proprioceptive plasticity after strabismus surgery may allow better visual rehabilitation. PMID:27656133

  7. Analysis of variabilities of serum proteomic spectra in patients with gastric cancer before and after operation

    Institute of Scientific and Technical Information of China (English)

    Hong Ren; Ning Du; Gang Liu; Heng-Tong Hu; Wei Tian; Zhi-Ping Deng; Jing-Sen Shi

    2006-01-01

    AIM: To study the variabilities of serum proteomic spectra in patients with gastric cancer before and after operation in order to detect the specific protein markers that can be used for quick diagnosis of gastric cancer.METHODS: Proteomic spectra of 46 serum samples from patients with gastric cancer before and after operation and 40 from normal individuals were generated by IMAC-Cu protein chip and surface-enhanced laser desorption/ionization time of flight mass spectrometry.RESULTS: Fourteen differentially expressed proteins in serum were screened by analysis of proteomic spectra of preoperative patients and normal individuals. We obtained 4 proteins (heat shock protein 27, glucoseregulated protein, prohibitin, protein disulfide isomerase A3) making up marker pattern which was able to class the patient-team and normal-team. These marker patterns yielded 95.7% sensitivity and 92.5% specificity,respectively. The proteins over-expressed in serum of preoperative patients were obviously down-regulated.CONCLUSION: Specific protein markers of gastric cancer can be used for the quick diagnosis of gastric cancer and judgment of prognosis. SELDI-TOF-MS is a useful tool for the detection and identification of new protein markers in serum.

  8. Canine distemper virus infection among wildlife before and after the epidemic.

    Science.gov (United States)

    Suzuki, Junko; Nishio, Yohei; Kameo, Yuki; Terada, Yutaka; Kuwata, Ryusei; Shimoda, Hiroshi; Suzuki, Kazuo; Maeda, Ken

    2015-11-01

    In 2007-2008, a canine distemper virus (CDV) epidemic occurred among wild animals in Wakayama Prefecture, Japan, and many mammals, including the wild boar and deer, were infected. In this study, CDV prevalence among wild animals was surveyed before and after the epidemic. At first, an enzyme-linked immunosorbent assay (ELISA) with horseradish peroxidase-conjugated protein A/G was established to detect CDV antibodies in many mammalian species. This established ELISA was available for testing dogs, raccoons and raccoon dogs as well as virus-neutralization test. Next, a serological survey of wild mammalians was conducted, and it was indicated that many wild mammalians, particularly raccoons, were infected with CDV during the epidemic, but few were infected before and after the epidemic. On the other hand, many raccoon dogs died during the epidemic, but CDV remained prevalent in the remaining population, and a small epidemic occurred in raccoon dogs in 2012-2013. These results indicated that the epidemic of 2007-2008 may have been intensified by transmission to raccoons. PMID:26074342

  9. Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment.

    Science.gov (United States)

    Chen, Chuan-Liang; Li, Hong; Xing, Xiao-Hong; Guan, Hai-Shan; Zhang, Jian-Hua; Zhao, Jun-Wu

    2015-01-01

    Bronchial asthma is a worldwide disease with high incidence. It not only harms children's physical and mental health, but it also brings a heavy burden to their families as well as the society. However, the trigger and pathogenesis of the disease remain unclear. This study aimed to analyze TRPV1 gene mutation and expression of cytokines in children with acute bronchial asthma before and after treatment, thus providing theoretical guidance for the diagnosis and treatment of bronchial asthma in children. Real-time quantitative polymerase chain reaction was adopted to detect TRPV1 mRNA expression level and enzyme-linked immuno sorbent assay was used to detect the serum total IgE level, eosinophil (EOS) number, IL-4, IL-5, and interferon (IFN) gamma levels in peripheral venous blood of children in the healthy control group and asthma group before and after treatment. Logistic regression analysis was applied to analyze the most essential factor inducing bronchial asthma in children. TRPV1 mRNA level of peripheral blood in the asthma group was higher than that in the control group before treatment (p asthma in children. TRPV1 gene mutation was closely related to bronchial asthma in children, which provided a theoretical basis for the treatment and prognosis of children with bronchial asthma.

  10. ESTIMATION OF MALONDIALDEHYDE AND VITAMIN-E LEVELS IN NEONATAL HYPERBILIRUBINEMIA BEFORE AND AFTER PHOTOTHERAPY

    Directory of Open Access Journals (Sweden)

    Sidrah, Tandrapad Priyanka, Asiya Naaz, Lakshmi Chaitanya G, Sridevi D

    2015-07-01

    Full Text Available Background: Hyperbilirubinemia is a common and benign problem in neonates worldwide. It is observed during the 1st week of life in approximately 60% of term neonates and 80% of preterm neonates. Phototherapy is most widely used as therapy for unconjugated hyperbilirubinemia. Phototherapy is related to oxidative stress and lipid peroxidation. The present study is undertaken to establish the relation between anti-oxidant status and the marker of lipid peroxidation in neonatal hyperbilirubinemia before and after phototherapy. Objectives: To estimate the levels of MDA (malondialdehyde and vit-E levels in neonatal hyperbilirubinemia before and after phototherapy. Material and Methods: A total of 30 patients were eligible for the study who met the inclusion and exclusion criteria. Blood sample was collected from neonates of preterm/full term age 1 to 10 days with hyperbilirubinemia undergoing phototherapy. Total Bilirubin, Direct Bilirubin, MDA and vit-E levels were estimated in serum by thiobarbituric acid (TBA method and Backer and Frank’s Method respectively. Results: The present study showed increase in Total bilirubin, Direct bilirubin, MDA and decrease in vit-E levels before phototherapy when compared to control group and same subjects after phototherapy showed decrease in Total bilirubin and Direct bilirubin, MDA and a further decrease in vit-E levels. Conclusion: From these results it is concluded though phototherapy had a beneficial effect in treatment of neonatal hyperbilirubinemia, supplementation of vit-E is necessary in addition to phototherapy.

  11. SELECTIVE EVALUATION OF TWO URINARY ENZYMES (NAG AND AAP BEFORE AND AFTER UNILATERAL SHOCK WAVE LITHOTRIPSY

    Directory of Open Access Journals (Sweden)

    M. R. Nikoobakht

    2006-09-01

    Full Text Available Biological effects extracorporeal shock wave lithotripsy (ESWL is not precisely known. We have evaluated two urinary enzymes activity N-acetyl-B-D-glucosamine (NAG and alanine amino peptidase (AAP before and after unilateral ESWL as markers for renal parenchymal damage. Forty eight patients with kidney stones (mean age 39 who had presented for the first time or at least one year after their previous lithotripsy underwent ESWL. Urinary specimens were collected before and after first, third and seventh days of lithotripsy and NAG, AAP were evaluated. These enzymes displayed the greatest activity 24 hours after ESWL with significant difference compared to the control group, (P < 0.05 versus 0.02. Elevation of urinary enzymes activity correlated with stone size particularly stones larger than 2 cm. These data suggest that there is some tubular and parenchymal damage induced by ESWL that needs time to get improved. The higher urinary enzyme activity in patients with larger stones ( > 2 cm is probably related to injury resulting from passage of smaller stones, produced after lithotripsy of a large stone, and it is suggested that these patients are treated with a safer procedure.

  12. Observed changes in aerosol physical and optical properties before and after precipitation events

    Science.gov (United States)

    Li, Xingmin; Dong, Yan; Dong, Zipeng; Du, Chuanli; Chen, Chuang

    2016-08-01

    Precipitation scavenging of aerosol particles is an important removal process in the atmosphere that can change aerosol physical and optical properties. This paper analyzes the changes in aerosol physical and optical properties before and after four rain events using in situ observations of mass concentration, number concentration, particle size distribution, scattering and absorption coefficients of aerosols in June and July 2013 at the Xianghe comprehensive atmospheric observation station in China. The results show the effect of rain scavenging is related to the rain intensity and duration, the wind speed and direction. During the rain events, the temporal variation of aerosol number concentration was consistent with the variation in mass concentration, but their size-resolved scavenging ratios were different. After the rain events, the increase in aerosol mass concentration began with an increase in particles with diameter variation patterns of aerosol scattering and absorption coefficients before and after the rain events were similar, but their scavenging ratios differed, which may have been related to the aerosol particle size distribution and chemical composition.

  13. Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty

    Directory of Open Access Journals (Sweden)

    Narciso Almeida Vieira

    2013-09-01

    Full Text Available This study isolated and quantified intestinal bacteria of children with cleft palate before and after palatoplasty. A prospective study was conducted from May 2007 to September 2008 on 18 children with cleft palate, aged one to four years, of both genders, attending a tertiary cleft center in Brazil for palatoplasty, to analyze the effect of surgical palate repair on the concentration of anaerobes Bacteroides sp, Bifidobacterium sp and microaerophiles Lactobacillus sp in feces of infants with cleft palate before and 24 hours after treatment with cefazolin for palatoplasty. There was significant reduction of Lactobacillus sp (p < 0.002, Bacteroides sp (p < 0.001 and Bifidobacterium sp (p = 0.021 after palatoplasty, revealing that surgery and utilization of cefazolin significantly influenced the fecal microbiota comparing collections before and after surgery. However, due to study limitations, it was not possible to conclude that other isolated factors, such as surgical stress, anesthetics and other medications used in palatoplasty might have a significant influence on the microbiota. Considering the important participation of the intestinal microbiota on both local and systemic metabolic and immunological activities of the host, professionals should be attentive to the possible influence of these changes in patients submitted to cleft repair.

  14. Thermographic imaging of the superficial temperature in racing greyhounds before and after the race.

    Science.gov (United States)

    Vainionpää, Mari; Tienhaara, Esa-Pekka; Raekallio, Marja; Junnila, Jouni; Snellman, Marjatta; Vainio, Outi

    2012-01-01

    A total of 47 racing greyhounds were enrolled in this study on two race days (in July and September, resp.) at a racetrack. Twelve of the dogs participated in the study on both days. Thermographic images were taken before and after each race. From the images, superficial temperature points of selected sites (tendo calcaneus, musculus gastrocnemius, musculus gracilis, and musculus biceps femoris portio caudalis) were taken and used to investigate the differences in superficial temperatures before and after the race. The thermographic images were compared between the right and left legs of a dog, between the raced distances, and between the two race days. The theoretical heat capacity of a racing greyhound was calculated. With regard to all distances raced, the superficial temperatures measured from the musculus gastrocnemius were significantly higher after the race than at baseline. No significant differences were found between the left and right legs of a dog after completing any of the distances. Significant difference was found between the two race days. The heat loss mechanisms of racing greyhounds during the race through forced conduction, radiation, evaporation, and panting can be considered adequate when observing the calculated heat capacity of the dogs. PMID:23097633

  15. Thermographic Imaging of the Superficial Temperature in Racing Greyhounds before and after the Race

    Directory of Open Access Journals (Sweden)

    Mari Vainionpää

    2012-01-01

    Full Text Available A total of 47 racing greyhounds were enrolled in this study on two race days (in July and September, resp. at a racetrack. Twelve of the dogs participated in the study on both days. Thermographic images were taken before and after each race. From the images, superficial temperature points of selected sites (tendo calcaneus, musculus gastrocnemius, musculus gracilis, and musculus biceps femoris portio caudalis were taken and used to investigate the differences in superficial temperatures before and after the race. The thermographic images were compared between the right and left legs of a dog, between the raced distances, and between the two race days. The theoretical heat capacity of a racing greyhound was calculated. With regard to all distances raced, the superficial temperatures measured from the musculus gastrocnemius were significantly higher after the race than at baseline. No significant differences were found between the left and right legs of a dog after completing any of the distances. Significant difference was found between the two race days. The heat loss mechanisms of racing greyhounds during the race through forced conduction, radiation, evaporation, and panting can be considered adequate when observing the calculated heat capacity of the dogs.

  16. Multifrequency EPR study on freeze-dried fruits before and after X-ray irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Yordanov, N.D. [Laboratory EPR, Institute of Catalysis, Bulgarian Academy of Sciences, 1113 Sofia (Bulgaria)]. E-mail: ndyepr@bas.bg; Aleksieva, K. [Laboratory EPR, Institute of Catalysis, Bulgarian Academy of Sciences, 1113 Sofia (Bulgaria); Dimitrova, A. [Laboratory EPR, Institute of Catalysis, Bulgarian Academy of Sciences, 1113 Sofia (Bulgaria); Georgieva, L. [Institute of Cryobiology and Food Technologies, 1162 Sofia (Bulgaria); Tzvetkova, E. [Institute of Cryobiology and Food Technologies, 1162 Sofia (Bulgaria)

    2006-09-15

    X-, K- and Q-band EPR studies on lyophilized whole pulp parts of blue plum, apricot, peach, melon as well as achens and pulp separately of strawberry before and after X-ray irradiation are reported. Before irradiation all samples show in X band a weak singlet EPR line with g=2.0030+/-0.0005, except melon, which is EPR silent. Immediately after irradiation all samples exhibit complex fruit-depending spectra, which decay with time and change to give, in ca. 50days, an asymmetric singlet EPR line with g=2.0041+/-0.0005. Only apricot pulp gave a typical ''sugar-like'' EPR spectrum. Singlet EPR lines recorded after irradiation in X -band are K- and Q-band resolved as typical anisotropic EPR spectra with g{sub ||}=2.0023+/-0.0003 and g{sub -}bar =2.0041+/-0.0005. In addition, K- and Q-band EPR spectra of all samples show a superposition with the six EPR lines of Mn{sup 2+} naturally present in the fruits. The saturation behavior of the EPR spectra of achens of lyophilized and fresh strawberry is also studied. The differences in g factors of samples before and after X-ray irradiation might be used for the identification of radiation processing of fruits in the case of pulp and the differences in the EPR saturation behavior might be used for the achens of strawberry.

  17. Variability of prefrontal neuronal discharges before and after training in a working memory task.

    Directory of Open Access Journals (Sweden)

    Xue-Lian Qi

    Full Text Available Variability of neural discharges can be revealing about the computations and network properties of neuronal populations during the performance of cognitive tasks. We sought to quantify neuronal variability in the prefrontal cortex of naïve monkeys that were only required to fixate, and to examine how this measure was altered by learning and execution of a working memory task. We therefore performed analysis of a large database of recordings in the same animals, using the same stimuli, before and after training. Our results indicate that the Fano Factor, a measure of variability, differs across neurons depending on their functional properties both before and after learning. Fano Factor generally decreased after learning the task. Variability was modulated by task events and displayed lowest values during the stimulus presentation. Nonetheless, the decrease in variability after training was present even prior to the presentation of any stimuli, in the fixation period. The greatest decreases were observed comparing populations of neurons that exhibited elevated firing rate during the trial events. Our results offer insights on how properties of the prefrontal network are affected by performance of a cognitive task.

  18. Variability of prefrontal neuronal discharges before and after training in a working memory task.

    Science.gov (United States)

    Qi, Xue-Lian; Constantinidis, Christos

    2012-01-01

    Variability of neural discharges can be revealing about the computations and network properties of neuronal populations during the performance of cognitive tasks. We sought to quantify neuronal variability in the prefrontal cortex of naïve monkeys that were only required to fixate, and to examine how this measure was altered by learning and execution of a working memory task. We therefore performed analysis of a large database of recordings in the same animals, using the same stimuli, before and after training. Our results indicate that the Fano Factor, a measure of variability, differs across neurons depending on their functional properties both before and after learning. Fano Factor generally decreased after learning the task. Variability was modulated by task events and displayed lowest values during the stimulus presentation. Nonetheless, the decrease in variability after training was present even prior to the presentation of any stimuli, in the fixation period. The greatest decreases were observed comparing populations of neurons that exhibited elevated firing rate during the trial events. Our results offer insights on how properties of the prefrontal network are affected by performance of a cognitive task. PMID:22848426

  19. Comparison of Perceptual Signs of Voice before and after Vocal Hygiene Program in Adults with Dysphonia

    Directory of Open Access Journals (Sweden)

    Seyyedeh Maryam khoddami

    2011-12-01

    Full Text Available Background and Aim: Vocal abuse and misuse are the most frequent causes of voice disorders. Consequently some therapy is needed to stop or modify such behaviors. This research was performed to study the effectiveness of vocal hygiene program on perceptual signs of voice in people with dysphonia.Methods: A Vocal hygiene program was performed to 8 adults with dysphonia for 6 weeks. At first, Consensus Auditory- Perceptual Evaluation of Voice was used to assess perceptual signs. Then the program was delivered, Individuals were followed in second and forth weeks visits. In the last session, perceptual assessment was performed and individuals’ opinions were collected. Perceptual findings were compared before and after the therapy.Results: After the program, mean score of perceptual assessment decreased. Mean score of every perceptual sign revealed significant difference before and after the therapy (p≤0.0001. «Loudness» had maximum score and coordination between speech and respiration indicated minimum score. All participants confirmed efficiency of the therapy.Conclusion: The vocal hygiene program improves all perceptual signs of voice although not equally. This deduction is confirmed by both clinician-based and patient-based assessments. As a result, vocal hygiene program is necessary for a comprehensive voice therapy but is not solely effective to resolve all voice problems.

  20. Background parenchymal enhancement in breast MRI before and after neoadjuvant chemotherapy: correlation with tumour response

    International Nuclear Information System (INIS)

    To correlate the decrease in background parenchymal enhancement (BPE) and tumour response measured with MRI in breast cancer patients treated with neoadjuvant chemotherapy (NAC). One hundred and forty-six MRI examinations of 73 patients with 80 biopsy-proven breast cancers who underwent breast MRI before and after NAC were retrospectively analysed. All images were reviewed by two blinded readers, who classified BPE into categories (BEC; 1 = minimal, 2 = mild, 3 = moderate, 4 = marked) before and after NAC. Histopathological and morphological tumour responses were analysed and compared. The distribution of BEC 1/2/3/4 was 25/46/18/11 % before and 78/20/2/0 % after NAC. On average, BPE decreased by 0.87 BEC. Cohen's kappa showed substantial agreement (k = 0.73-0.77) before and moderate agreement (k = 0.43-0.60) after NAC and moderate agreement (k = 0.62-0.60) concerning the change in BEC. Correlating the change in BPE with tumour response, the average decrease in BEC was 1.3 in cases of complete remission, 0.83 in cases with partial response, 0.85 in cases with stable disease and 0.40 in cases with progressive disease. Correlation analysis showed a significant correlation between the decrease in BEC and tumour response (r = -0.24, p = 0.03). BPE decreased by, on average, 0.87 BEC following NAC for breast cancer. The degree of BPE reduction seemed to correlate with tumour response. (orig.)

  1. Before and After How has the SNO NC measurement changed things?

    CERN Document Server

    Bahcall, J N; Peña-Garay, C; Bahcall, John N.; Peña-Garay, Carlos

    2002-01-01

    We present "Before and After" global oscillation solutions, as well as predicted "Before and After" values and ranges for eight future solar neutrino observables. The ``Before'' case includes all solar neutrino data (and some theoretical improvements) available prior to April 20, 2002 and the ``After'' case includes, in addition, the new SNO data on the CC, NC, and day-night asymmetry. The LMA solution is the only currently allowed MSW oscillation solution at a CL of 98.8 %. The LOW solution is allowed only at 2.5 sigma, SMA at 3.7 sigma, and pure sterile oscillations at 5.4 sigma. Small mixing angles are ``out''(pure sterile is ``way out''); MSW with large mixing angles is definitely ``in''. Vacuum oscillations are allowed, but not robustly, at 2.1 sigma. Precise maximal mixing is excluded at 3.2 sigma for MSW solutions and at 2.8 sigma for vacuum solutions. Most of the predicted values for future observables for the BOREXINO, KamLAND, and future SNO measurements are changed only by minor amounts by the incl...

  2. Marginal microleakage of class V composite restorations before and after AFP gel application

    Directory of Open Access Journals (Sweden)

    Davari Abdolrahim

    2015-01-01

    Full Text Available   Background and Aims: The most effective preventing tooth decay method is fluoride compounds applications. Some studies suggested that APF gels caused changes on the superficial physical properties of composite. Therefore, the purpose of this study was to evaluate the marginal microleakage of class V composite restorations before and after AFP gel application.   Materials and Methods: The class V cavities in buccal surfaces of 45 molar teeth were made in such a way that occlusal margin was placed in enamel and cervical margin in cement. In group 1, at first fluoride-therapy and then cavity preparation and restoration by composite resin was done. In group 2, at first the class V cavities were prepared and restored, then fluoride-therapy was carried out. In group 3, cavities were prepared and restored with no fluoride-therapy. The dye penetration rate in occlusal and cervical margins was examined by stereomicroscope. Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney test.   Results: There was no statistically significant difference between groups ( P=0.975.   Conclusion: Fluoride-therapy using AFP gel before and after class V composite restorations, had no significant effect on the microleakage of dentin and enamel margins.

  3. Background parenchymal enhancement in breast MRI before and after neoadjuvant chemotherapy: correlation with tumour response

    Energy Technology Data Exchange (ETDEWEB)

    Preibsch, H.; Wanner, L.; Bahrs, S.D.; Wietek, B.M.; Nikolaou, K.; Wiesinger, B. [University Hospital Tuebingen, Diagnostic and Interventional Radiology, Tuebingen (Germany); Siegmann-Luz, K.C. [Diagnostic Center for Breast Cancer and Screening Mammography Brandenburg Ost, Koenigs Wusterhausen (Germany); Oberlecher, E.; Hahn, M. [University Hospital Tuebingen, Department of Gynecology and Obstetrics, Tuebingen (Germany); Staebler, A. [University Hospital Tuebingen, Institute of Pathology and Neuropathology, Tuebingen (Germany)

    2016-06-15

    To correlate the decrease in background parenchymal enhancement (BPE) and tumour response measured with MRI in breast cancer patients treated with neoadjuvant chemotherapy (NAC). One hundred and forty-six MRI examinations of 73 patients with 80 biopsy-proven breast cancers who underwent breast MRI before and after NAC were retrospectively analysed. All images were reviewed by two blinded readers, who classified BPE into categories (BEC; 1 = minimal, 2 = mild, 3 = moderate, 4 = marked) before and after NAC. Histopathological and morphological tumour responses were analysed and compared. The distribution of BEC 1/2/3/4 was 25/46/18/11 % before and 78/20/2/0 % after NAC. On average, BPE decreased by 0.87 BEC. Cohen's kappa showed substantial agreement (k = 0.73-0.77) before and moderate agreement (k = 0.43-0.60) after NAC and moderate agreement (k = 0.62-0.60) concerning the change in BEC. Correlating the change in BPE with tumour response, the average decrease in BEC was 1.3 in cases of complete remission, 0.83 in cases with partial response, 0.85 in cases with stable disease and 0.40 in cases with progressive disease. Correlation analysis showed a significant correlation between the decrease in BEC and tumour response (r = -0.24, p = 0.03). BPE decreased by, on average, 0.87 BEC following NAC for breast cancer. The degree of BPE reduction seemed to correlate with tumour response. (orig.)

  4. TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate

    Directory of Open Access Journals (Sweden)

    Kabagambe Edmond K

    2009-10-01

    Full Text Available Abstract Background Inflammation is implicated in causing diabetes. We tested whether transcription factor 7 like-2 (TCF7L2 gene polymorphisms (rs12255372 and rs7903146, consistently associated with type 2 diabetes, are associated with plasma concentrations of inflammatory markers before and after three weeks of daily treatment with fenofibrate. Methods Men and women in the Genetics of Lipid-Lowering Drugs and Diet Network study (n = 1025, age 49 ± 16 y were included. All participants suspended use of lipid-lowering drugs for three weeks and were then given 160 mg/day of fenofibrate for three weeks. Inflammatory markers and lipids were measured before and after fenofibrate. ANOVA was used to test for differences across TCF7L2 genotypes. Results Under the additive or dominant model, there were no significant differences (P > 0.05 in the concentrations of inflammatory markers (hsCRP, IL-2, IL-6, TNF-α and MCP-1 across TCF7L2 genotypes in the period before or after treatment. For both rs12255372 and rs7903146, homozygote T-allele carriers had significantly higher (P Conclusion Overall these data show no association between TCF7L2 polymorphisms and the inflammatory markers suggesting that the effects of TCF7L2 on diabetes may not be via inflammation.

  5. Patients’ expectation and satisfaction with complete denture before and after the therapy

    Directory of Open Access Journals (Sweden)

    Zou Yun

    2015-01-01

    Full Text Available Background/Aim. Difficulties in the acceptance of dentures are multifactorial including psychosocial ones. It is questionable whether the patients’ satisfaction depends only on the complete denture therapy characteristics. The aim of the study was to evaluated patients’ expectation and satisfaction with complete dentures before and after the treatment concerning phonetics, chewing, comfort of use and aesthetics. Methods. Forty complete edentulous patients rated their expectation before and satisfaction after the treatment based on a questionnaire scores. Patient-related variables regarding age, gender and previous experience (whether worn complete denture or not were also recorded. Results. Patients’ rating for expectations were higher than the satisfaction after treatment regarding phonetics, chewing, comfort of use and aesthetics. A negative significant correlation was shown between the items before and after the treatment rating for phonetics, chewing, comfort of use and aesthetics. No statistical correlation was found between all the evaluated aspects’ (i.e. phonetics, chewing, comfort of use and aesthetics of expectation and satisfaction, and age, gender, and previous experience except a weak negative correlation noticed between age and comfort of denture use. Conclusion. Patients’ expectations ratings significantly exceeded their satisfactions. Expectations and satisfaction ratings were irrespective of gender and patients previous experience.

  6. Fatigue Analysis Before and After Shaker Exercise: Physiologic Tool for Exercise Design

    OpenAIRE

    White, Kevin T.; Easterling, Caryn; Roberts, Niles; Wertsch, Jacqueline; Shaker, Reza

    2008-01-01

    Recent studies suggest that the Shaker exercise induces fatigue in the upper esophageal sphincter (UES) opening muscles and sternocleidomastoid (SCM), with the SCMs fatiguing earliest. The aim of this study was to measure fatigue induced by the isometric portion of the Shaker exercise by measuring the rate of change in the median frequency (MF rate) of the power spectral density (PSD) function, which is interpreted as proportional to the rate of fatigue, from surface electromyography (EMG) of...

  7. Student Flows and Employment Opportunities before and after Implementation of a Third Year in Vocational Programmes at Upper Secondary School

    Science.gov (United States)

    Murray, Asa; Sundin, Sven

    2008-01-01

    The present study describes students flows before and after the latest reform of upper secondary school in which a third year as well as a new grading system and new entrance requirements were introduced in vocational programmes. Published and unpublished data on student flows through upper secondary school before and after implementation of the…

  8. Liver volume, portal vein flow, and clearance of indocyanine green and antipyrine in hyperthyroidism before and after antithyroid treatment

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Sonne, J; Court-Payen, M;

    1999-01-01

    The aim of the study was to examine liver volume, portal vein flow, and indocyanine green (ICG) and antipyrine clearance in hyperthyroidism before and after antithyroid drug treatment.......The aim of the study was to examine liver volume, portal vein flow, and indocyanine green (ICG) and antipyrine clearance in hyperthyroidism before and after antithyroid drug treatment....

  9. Alveolar dead space and capnographic variables before and after thrombolysis in patients with acute pulmonary embolism

    Directory of Open Access Journals (Sweden)

    Marcos Mello Moreira

    2008-11-01

    Full Text Available Marcos Mello Moreira1, Renato G G Terzi1, Carlos Heitor N Carvalho2, Antonio Francisco de Oliveira Neto3, Mônica Corso Pereira4, Ilma Aparecida Paschoal41Department of Surgery, State University of Campinas, School of Medical Sciences; 2Department of Cardiology, State University of Campinas, School of Medical Sciences; 3Intensive Care Unit of the State University of Campinas, School of Medical Sciences; 4Department of Pulmonology, State University of Campinas, School of Medical Sciences, Campinas, BrazilAbstract: Pulmonary embolism (PE is a common condition. The central aim of this study was to describe the use of volumetric capnography (VCap before and after fibrinolytic treatment of major PE. Lung scintigraphy was used as a base of comparison for the results of this treatment. We describe the cases of two conscious and spontaneously breathing patients (20- and 24-year-old women with major PE undergoing thrombolysis. Curves of CO2 were obtained by VCap and associated with arterial blood gas analysis and D-dimer. The pattern of VCap was compared with the VCap of health volunteers. Parameters also calculated were: P(a-etCO2 gradient, alveolar dead space fraction (AVDSf , late dead space fraction (f Dlate, and slope phase III (Slp III. The VCap results before and after thrombolysis for patients 1 and 2 were, respectively, P(a-etCO2: 12.6 to 5.8 and 7.9 to 1.6 (mmHg; AVDSf: 0.46 to 0.18 and 0.25 to 0.05; fDlate: 0.46 to 0.21 and 0.24 to 0.04; Slp III: 1.75 to 5.10 and 1.21 to 5.61 (mmHg/L. Lung scintigraphy was used to compare VCap results from the two subjects with VCap results from healthy volunteers and pigs before and after treatment associated with arterial blood gas, D-dimer, and showed satisfactory agreement.Keywords: pulmonary embolism, capnography, respiratory dead space, thrombolysis, fibrin fibrinogen degradation products/fibrin fragment D

  10. Relationship Between Vertical Jump Height and Swimming Start Performance Before and After an Altitude Training Camp.

    Science.gov (United States)

    García-Ramos, Amador; Padial, Paulino; de la Fuente, Blanca; Argüelles-Cienfuegos, Javier; Bonitch-Góngora, Juan; Feriche, Belén

    2016-06-01

    García-Ramos, A, Padial, P, de la Fuente, B, Argüelles-Cienfuegos, J, Bonitch-Góngora, J, and Feriche, B. Relationship between vertical jump height and swimming start performance before and after an altitude training camp. J Strength Cond Res 30(6): 1638-1645, 2016-This study aimed (a) to analyze the development in the squat jump height and swimming start performance after an altitude training camp, (b) to correlate the jump height and swimming start performance before and after the altitude training period, and (c) to correlate the percent change in the squat jump height with the percent change in swimming start performance. Fifteen elite male swimmers from the Spanish Junior National Team (17.1 ± 0.8 years) were tested before and after a 17-day training camp at moderate altitude. The height reached in the squat jump exercise with additional loads of 0, 25, 50, 75, and 100% of swimmers' pretest body weight and swimming start performance (time to 5, 10, and 15 m) were the dependent variables analyzed. Significant increases in the jump height (p ≤ 0.05; effect size [ES]: 0.35-0.48) and swimming start performance (p < 0.01; ES: 0.48-0.52) after the training period were observed. The start time had similar correlations with the jump height before training (r = -0.56 to -0.77) and after training (r = -0.50 to -0.71). The change in the squat jump height was inversely correlated with the change in the start time at 5 m (r = -0.47), 10 m (r = -0.73), and 15 m (r = -0.62). These results suggest that altitude training can be suitable to enhance explosive performance. The correlations obtained between the squat jump height and start time in the raw and change scores confirm the relevance of having high levels of lower-body muscular power to optimize swimming start performance. PMID:26473522

  11. [Perceived attractiveness and other characteristics of different male facial types before and after orthognathic surgery].

    Science.gov (United States)

    Allon, D M; Shmuly, T

    2015-07-01

    Orthognathic intervention has not only profound implications on the individual's function and esthetics, but also on the perception of his surrounding environment. In this study, frontal and profile photographs of 3 groups of men (a control group with normal profile and prognathic and retrognathic profiles, before and after orthognathic surgery) were shown in random order to a group of 83 women, who were asked to rate the pictures according to attractiveness and several personality traits on an analog scale. Results show that men with normal profiles got the most positive scores on all categories. Men with prognathic profiles were perceived as more aggressive and assertive, while men with retrognathic profiles were perceived as less intelligent and reliable. After orthognathic intervention both retrognathic and prognathic groups had a significant improvement in their scores, which were closer to the normal profile group. PMID:26548147

  12. Internal Exposure of a Seoul Subway Passenger due to Radon Inhalation: Before and After PSD Installation

    International Nuclear Information System (INIS)

    Radon is the major source of public exposure to natural radiation and is also known to cause lung cancer. Platform screen doors (PSD) were installed primarily for passenger's safety purposes. Radon concentration and aerosol distribution have been changed since PSD installation. In this study, we have assessed the annual effective dose of regular subway passengers, before and after PSD installation, by employing current available data on air concentration of radon in Seoul subways with aerosol size distributions taken into account. ICRP recommends that the reference value for internal dose from radon be between 1.0 and 20.0 mSv. Korean Ministry of Environment enacted the indoor radon regulation, which requires the indoor radon level should not exceed 148 Bq/m3. Radon concentrations in Seoul subways and annual dose estimates meet the requirements

  13. The severity of cutaneous leishmaniasis before and after the earthquake in Bam, southeastern Iran.

    Science.gov (United States)

    Sharifi, Iraj; Aflatoonian, Mohammad Reza; Aflatoonian, Behnaz; Kermanizadeh, Alireza

    2015-12-01

    Cutaneous leishmaniasis (CL) is a major disease with significant public health concerns in Iran. The objective of this study was to compare the severity of CL among the patients before and after the earthquake in the city and suburbs of Bam, southeastern Iran. This study was carried out as a descriptive-analytical manner by house-to-house visits in 2010 in Bam, southeastern Kerman province of Iran, where a massive earthquake has recently occurred. Overall, 1,481 individuals were selected as a cluster random sampling. Suspected lesions were detected by direct smear preparation and X(2) test was used for statistical significance at P risk factors particularly after a major natural disaster. Possibly the establishment of the CL health clinic to serve patients and to coordinate various activities had a major role in planning control strategies and thus reduction in severity of the CL disease. PMID:26688645

  14. The Role of Trust in Financial Customer-seller Relationships Before and After the Financial Crisis

    DEFF Research Database (Denmark)

    Hansen, Torben

    2014-01-01

    provider. Hence, as a direct managerial implication, financial service managers should consider investing additional resources in satisfying their customers in the after crisis era. In addition, it is suggested that managers should seek to rebuild the positive relationship between trust and loyalty......This study examines the role of trust in customer-seller relationships before and after the 2008 financial crisis. On the basis of two surveys comprising 1155 and 757 bank customers, respectively, it is shown that trust is less likely to mediate the relationship between satisfaction and loyalty...... after the financial crisis compared with before the financial crisis. The results suggest that consumers rely more on satisfaction and less on trust after the financial crisis compared with before the financial crisis when determining whether they should remain loyal to a particular financial service...

  15. Electron Spectroscopy Studies on SiC Films before and after Hydrogen Ion Irradiation

    Institute of Scientific and Technical Information of China (English)

    HUANG Ningkang; YANG Bing; WANG Dezhi

    2005-01-01

    The ion beam mixing prepared SiC films on stainless steel substrates were irradiated by hydrogen ion beam with an energy of 5 keV to a dose of 1×1018 ions/cm2. AES and XPS were used for the characterization of chemical bonding states of C and Si elements in SiC films as well as contamination oxygen before and after hydrogen ion irradiation in order to study the effect of hydrogen ion irradiation on SiC films and to understand oxygen behaviors in the SiC films prepared with ion beam mixing. The results show that contamination oxygen can react with silicon to form silicon oxides,and more oxygen entered into the films during hydrogen ion irradiation.In addition, oxygen also reacts with carbon related hydrogen to form species including carbon,hydrogen and oxygen.

  16. Analysis of Serum proteom before and after Intravenous Injection of wild ginseng herbal acupuncture

    Directory of Open Access Journals (Sweden)

    Tae-Sik Kang

    2004-12-01

    Full Text Available Objectives : To observe changes in the serum proteins before and after intravenous injection of wild ginseng herbal acupuncture. Methods : Blood was collected before and after the administration of wild ginseng herbal acupuncture and only the serum was centrifuged. Then differences in the spots on the scanned image after running 2-Dimensional electrophoresis were located and conducted mass analysis and protein identification. Results : Following results were obtained from the comparative analysis of serum proteins before and after the administration of wild ginseng herbal acupuncture. 1. 28 spots were identified before and after the administration. 2. In confirming manifestation degree, spots with more than two-times increase were 204, 803, 1505, 2205, 3105, 7104, 9001 spots, with more than one-time increase were 1101, 1302, 2013, 3009, 3010, 4002, 4009, 6706, 7103, 8006, 8101, and spots with decrease were 205, 801, 3205, 5202, 6105. 3. After conducting protein identification, proteins 205, 804, 1302, 4009, 6105, 6106 are unidentified yet, and 1101 is unnamed protein. Protein 204 is identified as complement receptor CR2-C3d, 801 as YAP1 protein, 803 as antitrypsin polymer, 1505 as PRO0684, 2013 and 3010 as proapolipoprotein, 2205 as USP48, 2403 as vitamin D binding protein, 3009 as complement component 4A preprotein, 3105 as immunoglobulin lambda chain, 3205 as transthyretin, 4002 as Ras-related protein Ral-A, 4204 as beta actin, 5202 and 7104 as apolipoprotein L1, 6704 as alpha 2 macroglobulin precursor, 7103 as complement component 3 precursor, 8006 as testis-specific protein Y, 8101 as transferrin, 9001 as (Alpha-Oxy, Beta-(C112gdeoxy T-State Human Hemoglobin, and 9003 as human hemoglobin. 4. Immune protein CR2-C3d, which acts against microbes and pathogenic organisms, and Antitrypsin(803, which is secreted with inflammatory response in the lungs, were increased by more than 200% after the administration of herbal acupuncture. 5

  17. Radioimmunological investigation of calcitonine in patients with reccurent calcium nephrolithiasis before and after calcium loading

    International Nuclear Information System (INIS)

    The diagnostic value of the changes in the calcitonine serum levels for differentiation of different types of hypercalciuria was assessed. The investigation was carried out with 15 patients with recurrent calcium nephrolithiasis and hypercalciuria, 4 - with primary hyperparathyroidism, 3 - with renal hypercalciuria, 7 - with absorptive hypercalciuria and 1 -with adenomectomy of the parathyroid glands. The calcitonine serum was determined before and after loading with 1000 mg Ca. A double-antibody radioimmunological method with high specificity, accuracy and sensitivity was used for calcitonine determination. The results of the study revealed that the serum calcitonine cannot serve as differential diagnostic criterion in determination of the type of hypercalciuria, but could be useful in the diagnosis of the medullary cancer of the thyroid gland. 3 figs., 5 refs

  18. CT value analysis and clinical significance before and after percutaneous lumbar discectomy

    Institute of Scientific and Technical Information of China (English)

    刘雷; 裴福兴; 宋跃明; 沈彬; 周宗科; 宋文锴; 张聪

    2002-01-01

    To provide theoretical basis for effect and mechanism of percutaneous lumbar discectomy in clinic. Methods: A total of 180 patients with lumbar intervertebral disc herniation were evaluated by CT on the fifth day before and after operation. Meanwhile, CT value was measured in the determined level and region. Results: After operation, CT value of the central and posterior determined point of herniated intervertebral disc was lower significantly than that before operation (P<0.01), but CT value of the anterior determined point was different insignificantly. The excellent and good results of the patients together were 83% postoperatively. Conclusions: The curative effect of percutaneous lumbar discectomy is achieved through reduction of lumbar intradiscal pressure.

  19. Tobacco smoke exposure in nonsmoking hospitality workers before and after a state smoking ban.

    Science.gov (United States)

    Jensen, Joni A; Schillo, Barbara A; Moilanen, Molly M; Lindgren, Bruce R; Murphy, Sharon; Carmella, Steven; Hecht, Stephen S; Hatsukami, Dorothy K

    2010-04-01

    Secondhand smoke exposure is estimated to account for 3,000 cancer deaths per year. Although several countries and states in the United States have passed comprehensive smoke-free laws to protect all employees, a significant number of workers are still not protected. The purpose of this study was to determine the effects of passing a comprehensive smoking ban that included bars and restaurants on biomarkers of nicotine and carcinogen exposure. The urines of nonsmoking employees (n = 24) of bars and restaurants that allowed smoking before the smoke-free law were analyzed before and after the law was passed in Minnesota. The results showed significant reductions in both total cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (free plus glucuronidated) after the ban was instituted. These results provide further support for the importance of protecting employees working in all venues. PMID:20354127

  20. Tobacco Smoke Exposure in Non-smoking Hospitality Workers Before and After a State Smoking Ban

    Science.gov (United States)

    Jensen, Joni A.; Schillo, Barbara A.; Moilanen, Molly M.; Lindgren, Bruce R.; Murphy, Sharon; Carmella, Steven; Hecht, Stephen S.; Hatsukami, Dorothy K.

    2010-01-01

    Secondhand smoke exposure is estimated to account for 3000 cancer deaths per year. While several countries and states in the U.S. have passed comprehensive smoke-free laws to protect all employees, a significant number of workers are still not protected. The purpose of this study was to determine the effects of passing a comprehensive smoking ban that included bars and restaurants on biomarkers of nicotine and carcinogen exposure. The urines of non-smoking employees (N=24) of bars and restaurants that allowed smoking prior to the smoke-free law were analyzed before and after the law was passed in Minnesota. The results showed significant reductions in both total cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) (free plus glucuronidated) after the ban was instituted. These results provide further support for the importance of protecting employees working in all venues. PMID:20354127

  1. Coronal CT of the paranasal sinuses before and after functional endoscotic sinus surgery

    International Nuclear Information System (INIS)

    Coronal CT of the paranasal sinuses and the ostiomeatal complex (OMC) was performed before and 12 months after bilateral functional endoscopic sinus surgery (FESS) in 30 patients with sinusitis and 12 patients with nasal polyposis. The extent of sinus mucosal thickening was graded, and the patency of the OMC was evaluated. After FESS, the percentage of open OMCs had increased from 42% to 83% in the sinusitis group, and from 8% to 45% in the polyposis group. There was only a small improvement in mucosal score in sinuses with opened OMC, so that the overall extent of sinus opacification before and after FESS was almost the same. Despite this, 91% of the patients reported clinical relief of symptoms. Preoperative coronal CT of the paranasal sinuses serves as an anatomical map for the surgeon, but there is no benefit of routine postoperative CT. (orig.)

  2. Do supranational EU institutions make a difference? EU asylum law before and after ‘communitarization’

    Science.gov (United States)

    Ripoll Servent, Ariadna; Trauner, Florian

    2014-01-01

    ABSTRACT This article examines whether the empowerment of the European Union's (EU) supranational institutions has had an impact on the development of EU asylum. By systematically investigating EU asylum law before and after ‘communitarization’, it argues that its ‘policy core’ has maintained a high degree of continuity. An advocacy coalition under the leadership of the interior ministers managed to co-opt pivotal actors in the newly empowered European Commission and European Parliament. By contenting themselves with changes of secondary order, these EU institutions accepted and institutionalized the restrictive and weakly integrated core of EU asylum set by the Council in the first negotiation round. Their role and decisions were driven not only by the negotiation dynamics and political expediency, but also by new inter- and intra-institutional norms fostering consensual practices. PMID:26924934

  3. Impurities especially titanium in the rare earth metal gadolinium-before and after solid state electrotransport

    Institute of Scientific and Technical Information of China (English)

    苗睿瑛; 张小伟; 朱琼; 张志琦; 王志强; 颜世宏; 陈德宏; 周林; 李宗安

    2014-01-01

    Gadolinium was prepared by conventional procedures of fluorination, reduction, distillation and solid state electrotransport (SSE). The electronegativities of the metals were found to have an important influence on the electrotransport process and result of the impurity element. Meanwhile, titanium particles in the distilled gadolinium as major metallic impurities were studied by high resolution transmission electron microscopy (HRTEM) before and after solid state electrotransport. The results showed that impurities especially titanium transported from anode to cathode during SSE. In the metal before SSE, there were impurities of titanium in strip shape or embedded round shape. After SSE processing, titanium particles in the metal smaller than 50 nm in the cathode, but existed 6 to 10 times bigger in the anode.

  4. Surface roughness and gloss of current CAD/CAM resin composites before and after toothbrush abrasion.

    Science.gov (United States)

    Koizumi, Hiroyasu; Saiki, Osamu; Nogawa, Hiroshi; Hiraba, Haruto; Okazaki, Tomoyo; Matsumura, Hideo

    2015-01-01

    The purpose of this study was to evaluate the gloss and surface roughness behaviors of newly developed CAD/CAM composite blocks with different filler contents and characteristics. The gloss and surface roughness were quantified before and after a toothbrush dentifrice abrasion test; the results were compared to the gloss and surface roughness of a ceramic CAD/CAM block. Knoop hardness was determined before abrasion test. The results were analyzed by ANOVA, Tukey HSD, and Dunnett t test (pVita Enamic>Gradia block>Shofu Block HC, Lava Ultimate≥Katana Avencia block≥Cerasmart. After toothbrush abrasion, a significant difference in the gloss unit was detected between the Shofu Block HC material and the ceramic block. The Ra and Rz of the Cerasmart and Shofu Block HC materials were significantly larger than those of the ceramic block after toothbrush abrasion. PMID:26632238

  5. The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflight

    Science.gov (United States)

    Arnaud, Sara B.; Navidi, Meena; Deftos, Leonard; Thierry-Palmer, Myrtle; Dotsenko, Rita; Bigbee, Allison; Grindeland, Richard E.

    2002-01-01

    The calcium endocrine system of nonhuman primates can be influenced by chairing for safety and the weightless environment of spaceflight. The serum of two rhesus monkeys flown on the Bion 11 mission was assayed pre- and postflight for vitamin D metabolites, parathyroid hormone, calcitonin, parameters of calcium homeostasis, cortisol, and indexes of renal function. Results were compared with the same measures from five monkeys before and after chairing for a flight simulation study. Concentrations of 1,25-dihydroxyvitamin D were 72% lower after the flight than before, and more than after chairing on the ground (57%, P endocrine system were similar to the effects of chairing on the ground, but were more pronounced. Reduced intestinal calcium absorption, losses in body weight, increases in cortisol, and higher postflight blood urea nitrogen were the changes in flight monkeys that distinguished them from the flight simulation study animals.

  6. Hematologic profile of hematophagous Desmodus rotundus bats before and after experimental infection with rabies virus

    Directory of Open Access Journals (Sweden)

    Marilene Fernandes de Almeida

    2014-06-01

    Full Text Available Introduction Hematophagous Desmodus rotundus bats play an important role in the rabies lifecycle. This study describes the hematological profile of these bats before and after experimental infection with rabies virus. Methods Cells counts were performed in a Neubauer chamber. Results The average values of erythrocytes and leucocytes counts in blood before experimental infections were 9.97 × 106mm3 and 4.80 × 103mm3, respectively. Neutrophils represented 69.9% of white blood cells and the lymphocytes represented 26.9%. Following the experimental infections, the average numbers of erythrocytes and leucocytes was 9.43 × 106mm3 and 3.98 × 103mm3, respectively. Neutrophils represented 40% of white blood cells and the lymphocytes represented 59%. Conclusions The hematological profile given in this study can serve as reference values for D. rotundus bats.

  7. Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation

    Directory of Open Access Journals (Sweden)

    Bruno T. Zacharias

    2014-12-01

    Full Text Available Objective: To evaluate the influence of end-stage liver disease and orthotopic liver transplantation in the pituitary function and hormone metabolism before and after liver transplantation. Methods: In a prospective study, serum levels of follicle stimulating hormone (FSH, luteinizing hormone (LH, estradiol (E2 and prolactin (PRL of 30 male patients with cirrhosis were determined two to four hours before and six months after liver transplantation. The results were compared according to the Model for End-stage Liver Disease (MELD. Results: male patients with liver cirrhosis have hypogonadism. FSH was normal, but inappropriately low due to androgen failure; E2 and PRL, on their turn, were high. After liver transplantation, FSH and LH levels increased (p 18. The severity of cirrhosis had no influence on FSH, PRL and LH.

  8. Band Saw Blade Crack before and after Comparison and Analysis of Experiments (2

    Directory of Open Access Journals (Sweden)

    Gao Jin-gui

    2016-01-01

    Full Text Available Based on MJ3310 woodworking band saw machine as the research object, under the no-load and load of Vib system vibration signal acquisition, processing and analysis software of band saw blade transverse vibration test and the signal acquisition and analysis of the collected signals obtained: to determine the transverse vibration displacement 5.66μm ~ 7.86μm and the main vibration frequency between 624 Hz ~ 792 Hz, then saw blade crack at least 3 mm, need timely saw blade, cutting high hardness of wood band saw blade transverse vibration displacement and frequency will increase sharply. Can be generated according to the band saw blade crack before and after the changing rule of the horizontal vibration displacement and frequency of transverse vibration and scope, judgment and replacement time of saw blade saw blade defect types, which can fully rational utilization of saw blade work effectively.

  9. The Truth Before and After: Brain Potentials Reveal Automatic Activation of Event Knowledge during Sentence Comprehension.

    Science.gov (United States)

    Nieuwland, Mante S

    2015-11-01

    How does knowledge of real-world events shape our understanding of incoming language? Do temporal terms like "before" and "after" impact the online recruitment of real-world event knowledge? These questions were addressed in two ERP experiments, wherein participants read sentences that started with "before" or "after" and contained a critical word that rendered each sentence true or false (e.g., "Before/After the global economic crisis, securing a mortgage was easy/harder"). The critical words were matched on predictability, rated truth value, and semantic relatedness to the words in the sentence. Regardless of whether participants explicitly verified the sentences or not, false-after-sentences elicited larger N400s than true-after-sentences, consistent with the well-established finding that semantic retrieval of concepts is facilitated when they are consistent with real-world knowledge. However, although the truth judgments did not differ between before- and after-sentences, no such sentence N400 truth value effect occurred in before-sentences, whereas false-before-sentences elicited an enhanced subsequent positive ERPs. The temporal term "before" itself elicited more negative ERPs at central electrode channels than "after." These patterns of results show that, irrespective of ultimate sentence truth value judgments, semantic retrieval of concepts is momentarily facilitated when they are consistent with the known event outcome compared to when they are not. However, this inappropriate facilitation incurs later processing costs as reflected in the subsequent positive ERP deflections. The results suggest that automatic activation of event knowledge can impede the incremental semantic processes required to establish sentence truth value. PMID:26244719

  10. The Truth Before and After: Brain Potentials Reveal Automatic Activation of Event Knowledge during Sentence Comprehension.

    Science.gov (United States)

    Nieuwland, Mante S

    2015-11-01

    How does knowledge of real-world events shape our understanding of incoming language? Do temporal terms like "before" and "after" impact the online recruitment of real-world event knowledge? These questions were addressed in two ERP experiments, wherein participants read sentences that started with "before" or "after" and contained a critical word that rendered each sentence true or false (e.g., "Before/After the global economic crisis, securing a mortgage was easy/harder"). The critical words were matched on predictability, rated truth value, and semantic relatedness to the words in the sentence. Regardless of whether participants explicitly verified the sentences or not, false-after-sentences elicited larger N400s than true-after-sentences, consistent with the well-established finding that semantic retrieval of concepts is facilitated when they are consistent with real-world knowledge. However, although the truth judgments did not differ between before- and after-sentences, no such sentence N400 truth value effect occurred in before-sentences, whereas false-before-sentences elicited an enhanced subsequent positive ERPs. The temporal term "before" itself elicited more negative ERPs at central electrode channels than "after." These patterns of results show that, irrespective of ultimate sentence truth value judgments, semantic retrieval of concepts is momentarily facilitated when they are consistent with the known event outcome compared to when they are not. However, this inappropriate facilitation incurs later processing costs as reflected in the subsequent positive ERP deflections. The results suggest that automatic activation of event knowledge can impede the incremental semantic processes required to establish sentence truth value.

  11. Sleep Problems Before and After Acute Myocardial Infarction: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Belguzar Kara

    2012-12-01

    Full Text Available AIM: The purpose of this study was to compare patients’ sleep problems before and after acute myocardial infarction (AMI and also to determine factors affecting sleep problems in patients undergoing AMI. METHOD: This cross-sectional study was conducted at the Coronary Intensive Care Unit in a training hospital between January 1 and April 30, 2007. The sample of the study was composed of 26 patients with a first-ever AMI. Data were collected by using a questionnaire to determine the patient and illness-related descriptive characteristics and the Post Sleep Inventory Scale (PSIS. The Shapiro-Wilks test, descriptive statistics, paired samples t test, Mann Whitney U test, Wilcoxon test, reliability analysis and correlation analysis were used to analyze the data. RESULTS: The mean age of the study group was 53.2 ± 12.6 years and approximately 81% were males. The patients’ mean bedtime (t= -3.422, p= 0.001, quality of nocturnal sleep (t= -3.221, p= 0.001, awakening (t =-3.533, p<0.001 and total PSIS scores (t= -5.652, p<0.001 were significantly higher after AMI compared to before AMI. The mean PSIS scores of patients undergoing AMI were statistically significant different by gender (z= -2.164, p= 0.030 and working status (z= -2.171, p= 0.030. There was a negative correlation between the PSIS score and haemoglobin and haematocrit values (r= -0.503, p<0.01; r= -0.473, p<0.05; respectively. CONCLUSION: There were differences in the patients’ reported sleep problems between before and after AMI. The results of this study showed that sleep problems were more common among women, patients not working and those with anemia. Nurses should be aware of the sleep problems and factors that affect to sleep problems. [TAF Prev Med Bull 2012; 11(6.000: 687-694

  12. Change in antihypertensive drug prescribing after guideline implementation: a controlled before and after study

    Directory of Open Access Journals (Sweden)

    Helin-Salmivaara Arja

    2011-08-01

    Full Text Available Abstract Background Antihypertensive drug choices and treatment levels are not in accordance with the existing guidelines. We aimed to assess the impact of a guideline implementation intervention on antihypertensive drug prescribing. Methods In this controlled before and after study, the effects of a multifaceted (education, audit and feedback, local care pathway quality programme was evaluated. The intervention was carried out in a health centre between 2002 and 2003. From each health care unit (n = 31, a doctor-nurse pair was trained to act as peer facilitators in the intervention. All antihypertensive drugs prescribed by 25 facilitator general practitioners (intervention GPs and 53 control GPs were retrieved from the nationwide Prescription Register for three-month periods in 2001 and 2003. The proportions of patients receiving specific antihypertensive drugs and multiple antihypertensive drugs were measured before and after the intervention for three subgroups of hypertension patients: hypertension only, with coronary heart disease, and with diabetes. Results In all subgroups, the use of multiple concurrent medications increased. For intervention patients with hypertension only, the odds ratio (OR was 1.12 (95% CI 0.99, 1.25; p = 0.06 and for controls 1.13 (1.05, 1.21; p = 0.002. We observed no statistically significant differences in the change in the prescribing of specific antihypertensive agents between the intervention and control groups. The use of agents acting on the renin-angiotensin-aldosterone system increased in all subgroups (hypertension only intervention patients OR 1.19 (1.06, 1.34; p = 0.004 and controls OR 1.24 (1.15, 1.34; p Conclusions A multifaceted guideline implementation intervention does not necessarily lead to significant changes in prescribing performance. Rigorous planning of the interventions and quality projects and their evaluation are essential.

  13. Infinitival before and after-clauses in European Portuguese: temporal and aspectual properties

    Directory of Open Access Journals (Sweden)

    Purificação Silvano

    2015-06-01

    Full Text Available The main goal of this paper is to discuss temporal and aspectual features of sentences with clauses introduced by the connectives antes de + Infinitivo (‘before’ + Infinitive and depois de + Infinitivo (‘after’ + Infinitive combined with situations in the Pretérito Perfeito in European Portuguese. Our discussion is based on the widespread view that these clauses are locating adverbials (cf. Kamp and Reyle (1993 with temporal information of anteriority, in the case of antes de, and posteriority, in the case of depois de. However, this analysis is not as straightforward as one would expect, because, while before-clauses consistently render the same temporal relation (of anteriority, after-clauses may convey a temporal relation of inclusion, in addition to the standard posteriority relation. We put forward the hypothesis that aspectual characteristics play an important role in these differences, insofar as allowing a temporal reading that at first sight is not predicted from the semantic nature of the connective. In order to maintain a uniform treatment of before and after-clauses with respect to their temporal features, accounting simultaneously for the differences that emerge in their linguistic behaviour, we claim, along with Beaver & Condoravdi (2003 and Condoravdi (2010, that the locating time interval provided by these clauses is bounded to the left, but not to the right, that is, what is focused is the initial frontier of the situation that provides the time interval, leaving the final one undetermined. Furthermore, we show that, although the temporal mechanisms are parallel, the interference of aspectual properties leads to interesting differences in the final interpretation of before and after-sentences.

  14. Radiocesium in Canadian Arctic Beluga and Caribou Before and After the Fukushima Accident of 2011

    Energy Technology Data Exchange (ETDEWEB)

    Stocki, Trevor J.; Pellerin, Eric; Bergman, Lauren; Mercier, Jean-Francois; Genovesi, Linda; Cooke, Michael; Todd, Bonnie; Sandles, Diane; Whyte, Jeff [Radiation Protection Bureau, Health Canada, AL6302D, 775 Brookfield Road, Ottawa, Ontario, Canada, K1A 0K9 (Canada); Gamberg, Mary [Gamberg Consulting, Whitehorse, Yukon (Canada); Loseto, Lisa [Fisheries and Oceans Canada, Winnipeg, Manitoba (Canada); Wang, X. [Environment Canada, Burlington Ontario (Canada)

    2014-07-01

    Following the Fukushima Daiichi nuclear accident in March 2011, northern Canadians expressed concerns about the levels of radioactive contaminants in important traditional foods. Therefore, a study has been conducted to measure the levels of radionuclides in Arctic caribou and beluga whales. The main radionuclide of concern is cesium-137, which has a half-life of 30 years and is chemically similar to potassium, thereby easily accumulating in plants and animals. Cesium-137 was released into the atmosphere during nuclear weapons tests in the 1950's-60's and during nuclear accidents, such as Chernobyl. Previous studies have been made on the cesium-137 levels in Canadian caribou herds from 1958 to 2000, allowing researchers to determine the amount of cesium-137 in caribou specifically attributable to atmospheric weapons testing and the Chernobyl accident. Samples of lichens, mushrooms, caribou and beluga whales taken before and after the Fukushima accident were freeze dried, homogenized, and measured using gamma ray spectroscopy to identify the radionuclides present and determine the radioactivity concentration in the samples. To determine the efficiency of the detectors for the different sized samples, physical calibration standards were used and virtual simulations were also performed. A comparison of the caribou samples from before and after the accident has indicated no increase in radioactivity as a result of the Fukushima accident. Results are consistent with pre-Fukushima levels for these caribou. No Cs-137 was found in the pre-Fukushima beluga whale samples, even if all the measurements were combined into one spectrum. In the individual post-Fukushima beluga whale samples, Cs-137 was also not found. However, when the post-Fukushima beluga whale measurements were combined, an insignificant amount of radioactive Cs-137 was found. The amount of this Cs-137 was about 200 times smaller than the natural radioactive potassium in the samples. Most likely the

  15. Radiocesium in Canadian Arctic Beluga and Caribou Before and After the Fukushima Accident of 2011

    International Nuclear Information System (INIS)

    Following the Fukushima Daiichi nuclear accident in March 2011, northern Canadians expressed concerns about the levels of radioactive contaminants in important traditional foods. Therefore, a study has been conducted to measure the levels of radionuclides in Arctic caribou and beluga whales. The main radionuclide of concern is cesium-137, which has a half-life of 30 years and is chemically similar to potassium, thereby easily accumulating in plants and animals. Cesium-137 was released into the atmosphere during nuclear weapons tests in the 1950's-60's and during nuclear accidents, such as Chernobyl. Previous studies have been made on the cesium-137 levels in Canadian caribou herds from 1958 to 2000, allowing researchers to determine the amount of cesium-137 in caribou specifically attributable to atmospheric weapons testing and the Chernobyl accident. Samples of lichens, mushrooms, caribou and beluga whales taken before and after the Fukushima accident were freeze dried, homogenized, and measured using gamma ray spectroscopy to identify the radionuclides present and determine the radioactivity concentration in the samples. To determine the efficiency of the detectors for the different sized samples, physical calibration standards were used and virtual simulations were also performed. A comparison of the caribou samples from before and after the accident has indicated no increase in radioactivity as a result of the Fukushima accident. Results are consistent with pre-Fukushima levels for these caribou. No Cs-137 was found in the pre-Fukushima beluga whale samples, even if all the measurements were combined into one spectrum. In the individual post-Fukushima beluga whale samples, Cs-137 was also not found. However, when the post-Fukushima beluga whale measurements were combined, an insignificant amount of radioactive Cs-137 was found. The amount of this Cs-137 was about 200 times smaller than the natural radioactive potassium in the samples. Most likely the Cs-137

  16. Diffusion-weighted MR imaging of benign and malignant breast lesions before and after contrast enhancement

    International Nuclear Information System (INIS)

    Purpose: Many publications describe the use of diffusion-weighted imaging (DWI) in breast MRI. This article addresses the question of when to apply the DWI sequence in the course of the scan protocol. The effect of T1-shortening contrast media (CM) on the ADC values of breast lesions is investigated. Materials and Methods: Data were acquired on a 1.5 T scanner. 60 patients with 79 lesions (20 benign, 59 malignant) were included. The DWI sequence (4 mm slice thickness, b-values: 50, 400, 800) was applied before and after CM administration. Before calculating the ADC map, the b50, b400 and b800 series were analyzed concerning lesion displacement. ADC values before and after CM application were compared. Results: The mean lesion size was 1.5 ± 0.8 cm. On the basis of the b50 and b400 measurements, the mean ADC value of benign lesions was 1.89 ± 0.30 x 10-3 mm2/s before and 1.85 ± 0.28 x 10-3 mm2/s after CM administration. The consecutive values for two pure mucinous carcinomas were 1.88 x 10-3 mm2/s and 1.81 x 103 mm2/s and for the remaining malignant lesions 1.00 ± 0.18 x 10-3 mm2/s and 0.88 ± 0.21 x 10-3 mm2. On the basis of the b50, b400 and b800 measurements, the mean ADC value of benign lesions was 1.99 ± 0.37 x 10-3 mm2/s before and 1.97 ± 0.30 x 10-3 mm2/s after CM application, whereas the mean ADC value of the malignant lesions was 0.90 ± 0.14 x 10-3 mm2/s before and 0.80 ± 0.14 x 10-3 mm2/s after CM application. While there was no significant change for benign lesions, the ADC value decrease in post-contrast malignant lesions was highly significant. Conclusion: DWI after CM is possible and even leads to slightly better lesion discrimination between benign and malignant. However, further studies need to be performed to verify this. (orig.)

  17. Ovarian activity before and after gonadal suppression by GnRH-a in patients with polycystic ovary syndrome, hyperandrogenism, hyperinsulinism and acanthosis nigricans

    OpenAIRE

    Motta E.L.A.; Baracat E.C.; Haidar M.A.; Juliano I.; Lima G.R.

    1998-01-01

    OBJECTIVE: To investigate the ovarian activity before and after gonadal suppression with GnRH-analog in patients with PCO, hyperandrogenism, hyperinsulinism and acanthosis nigricans. DESIGN: Controlled clinical study. SETTING: Tertiary academic medical center. PATIENTS: Six patients with clinical findings of PCO, hirsutism and acanthosis nigricans. INTERVENTIONS: Morning blood samples in the follicular phase to determine the steroid levels, glucose and insulin curve, comparing to a control gr...

  18. Childhood IQ and all-cause mortality before and after age 65: Prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies

    OpenAIRE

    Hart, C. L.; M. D. Taylor; Davey Smith, G; Whalley, L.J.; Starr, J M; Hole, D; Wilson, V.; Deary, I J

    2005-01-01

    OBJECTIVES: The objective was to investigate how childhood IQ related to all-cause mortality before and after age 65. DESIGN: The Midspan prospective cohort studies, followed-up for mortality for 25 years, were linked to individuals' childhood IQ from the Scottish Mental Survey 1932. METHODS: The Midspan studies collected data on risk factors for cardiorespiratory disease from a questionnaire and at a screening examination, and were conducted on adults in Scotland in the 1970s. An age 11 IQ f...

  19. Lung function in volunteers before and after exposure to trichloramine in indoor pool environments and asthma in a cohort of pool workers

    OpenAIRE

    Nordberg, Gunnar F.; Lundström, Nils-Göran; Forsberg, Bertil; Hagenbjörk-Gustafsson, Annika; Lagerkvist, Birgitta J-son; Nilsson, Johan; Svensson, Mona; Blomberg, Anders; Nilsson, Leif; Bernard, Alfred; Dumont, Xavier; Bertilsson, Helen; Eriksson, Kåre

    2012-01-01

    OBJECTIVES: Exposure to trichloramine (NCl(3)) in indoor swimming-pool environments is known to cause mucous membrane irritation, but if it gives rise to changes in lung function or asthma in adults is not known. (1) We determined lung function in volunteers before and after exposure to indoor pool environments. (2) We studied the occurrence of respiratory symptoms and asthma in a cohort of pool workers. DESIGN/METHODS/PARTICIPANTS: (1) We studied two groups of volunteers, 37 previously non-e...

  20. Routine testing of liver function before and after elective laparoscopic cholecystectomy: is it necessary?

    LENUS (Irish Health Repository)

    Ahmad, Nasir Zaheer

    2012-01-31

    BACKGROUND AND OBJECTIVES: Liver function tests (LFTs) include alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bilirubin. The role of routine testing before and after laparoscopic cholecystectomy was evaluated in this study. PATIENTS AND METHODS: A total of 355 patients were retrospectively analyzed by examining the LFTs the day before, the day after, and 3 weeks after the surgery. The Wilcoxon signed-rank test and Student t test were performed to determine statistical significance. RESULTS: Alterations in the serum AST, ALT, and GGT were seen on the first postoperative day. Minor changes were seen in bilirubin and ALP. An overall disturbance in the LFTs was seen in more than two-thirds of the cases. Repeat LFTs performed after 3 weeks on follow-up were found to be within normal limits. CONCLUSION: Mild-to-moderate elevation in preoperative LFTs may not be associated with any deleterious effect, and, in the absence of clinical indications, routine preoperative or postoperative liver function testing is unnecessary.

  1. Mechanical and Microstructural Evaluations of Lightweight Aggregate Geopolymer Concrete before and after Exposed to Elevated Temperatures

    Directory of Open Access Journals (Sweden)

    Mohammed Binhussain

    2013-10-01

    Full Text Available This paper presents the mechanical and microstructural characteristics of a lightweight aggregate geopolymer concrete (LWAGC synthesized by the alkali-activation of a fly ash source (FA before and after being exposed to elevated temperatures, ranging from 100 to 800 °C. The results show that the LWAGC unexposed to the elevated temperatures possesses a good strength-to-weight ratio compared with other LWAGCs available in the published literature. The unexposed LWAGC also shows an excellent strength development versus aging times, up to 365 days. For the exposed LWAGC to the elevated temperatures of 100 to 800 °C, the results illustrate that the concretes gain compressive strength after being exposed to elevated temperatures of 100, 200 and 300 °C. Afterward, the strength of the LWAGC started to deteriorate and decrease after being exposed to elevated temperatures of 400 °C, and up to 800 °C. Based on the mechanical strength results of the exposed LWAGCs to elevated temperatures of 100 °C to 800 °C, the relationship between the exposure temperature and the obtained residual compressive strength is statistically analyzed and achieved. In addition, the microstructure investigation of the unexposed LWAGC shows a good bonding between aggregate and mortar at the interface transition zone (ITZ. However, this bonding is subjected to deterioration as the LWAGC is exposed to elevated temperatures of 400, 600 and 800 °C by increasing the microcrack content and swelling of the unreacted silicates.

  2. Circulating tumor DNA detection in lung cancer patients before and after surgery

    Science.gov (United States)

    Guo, Nannan; Lou, Feng; Ma, Yongfu; Li, Jie; Yang, Bo; Chen, Wei; Ye, Hua; Zhang, Jing-Bo; Zhao, Ming-Yu; Wu, Wen-Jun; Shi, Rong; Jones, Lindsey; Chen, Katherine S.; Huang, Xue F.; Chen, Si-Yi; Liu, Yang

    2016-01-01

    Circulating tumor DNA (ctDNA) in peripheral blood is a “liquid biopsy” that contains representative tumor information including gene mutations. Additionally, repeated ctDNA samples can be easily obtained to monitor response to treatment and disease progression, which may be especially valuable to lung cancer patients with tumors that cannot be easily biopsied or removed. To investigate the changes in ctDNA after surgical tumor resection, tumor and blood samples obtained before and after surgery were collected prospectively from 41 non-small lung cancer (NSCLC) patients. Somatic driver mutations in tumor DNA (tDNA) and pre- and post-op plasma ctDNA sample pairs were identified by targeted sequencing in several genes including EGFR, KRAS, and TP53 with an overall study concordance of 78.1% and sensitivity and specificity of 69.2% and 93.3%, respectively. Importantly, the frequency of 91.7% of ctDNA mutations decreased after surgery and these changes were observed as little as 2 days post-op. Moreover, the presence of ctDNA had a higher positive predictive value than that of six tumor biomarkers in current clinical use. This study demonstrates the use of targeted sequencing to reliably identify ctDNA changes in response to treatment, indicating a potential utility of this approach in the clinical management of NSCLC. PMID:27641744

  3. Biochemical Evaluation of Serum Adiponectin Level in Egyptian Breast Cancer Patients before and after Treatment

    International Nuclear Information System (INIS)

    In this study, serum adiponectin level was evaluated in 35 primary breast cancer patients and 10 healthy females, before and after treatment to assess if there is a relation between it and breast cancer, and to find out if it has a prognostic value. Serum adiponectin level was significantly lower in all and postmenopausal breast cancer patients before taking any type of treatment, and non-significantly lower in locally advanced breast cancer patients after treatment by 4 cycles of neoadjuvant chemotherapy than healthy controls. Non-significant elevations was shown after treatment by surgery, and also after completing treatment by surgery followed by taking 2 cycles of adjuvant chemotherapy followed by treatment by radiotherapy in case of premenopausal locally advanced breast cancer patients. Triglycerides showed significantly higher level in all groups of patients. There was statistical negative correlation between serum adiponectin level and body mass index (BMI) in postmenopausal healthy controls, and between serum adiponectin level and BMI, triglycerides in all and postmenopausal breast cancer patients before taking any type of treatment. In conclusion, this study suggests that low serum adiponectin level is likely to be associated with increased breast cancer risk, particularly among postmenopausal women. The association between obesity and breast cancer risk might be partly explained by adiponectin

  4. Effects of education on second births before and after societal transition: Evidence from the Estonian GGS

    Directory of Open Access Journals (Sweden)

    Martin Klesment

    2010-05-01

    Full Text Available This article examines the influence of educational attainment and enrolment on second births in Estonia, comparing the patterns before and after the onset of the societal transformation of the 1990s. While many Northern and Western European countries have shown a positive relationship between female education and second births, this pattern has not been found in Central and East European countries. Against that background, Estonia offers an interesting case with noticeably high second birth intensities for highly educated women. In the state socialist period, after controlling for the influence of other characteristics, including the partner's education, women with tertiary education were found to have higher second birth intensity than women from any lower educational strata. In the postsocialist period, the difference has grown smaller, but women with tertiary education still display a significantly higher transition rate to second birth than their counterparts with secondary education. Following the presentation of empirical findings, the article discusses the mechanisms that could underlie the observed relationship between education and fertility decisions in the changing societal context. The analysis employs microdata from the Estonian Generations and Gender Survey (GGS, conducted in 2004-05.

  5. Longitudinal data on cortical thickness before and after working memory training

    Science.gov (United States)

    Metzler-Baddeley, Claudia; Caeyenberghs, Karen; Foley, Sonya; Jones, Derek K.

    2016-01-01

    The data and supplementary information provided in this article relate to our research article “Task complexity and location specific changes of cortical thickness in executive and salience networks after working memory training” (Metzler-Baddeley et al., 2016) [1]. We provide cortical thickness and subcortical volume data derived from parieto-frontal cortical regions and the basal ganglia with the FreeSurfer longitudinal analyses stream (http://surfer.nmr.mgh.harvard.edu [2]) before and after Cogmed working memory training (Cogmed and Cogmed Working Memory Training, 2012) [3]. This article also provides supplementary information to the research article, i.e., within-group comparisons between baseline and outcome cortical thickness and subcortical volume measures, between-group tests of performance changes in cognitive benchmark tests (www.cambridgebrainsciences.com [4]), correlation analyses between performance changes in benchmark tests and training-related structural changes, correlation analyses between the time spent training and structural changes, a scatterplot of the relationship between cortical thickness measures derived from the occipital lobe as control region and the chronological order of the MRI sessions to assess potential scanner drift effects and a post-hoc vertex-wise whole brain analysis with FreeSurfer Qdec (https://surfer.nmr.mgh.harvard.edu/fswiki/Qdec [5]). PMID:27115029

  6. Condition of hearing sense and tinnitus before and after the treatment of otosclerosis

    Directory of Open Access Journals (Sweden)

    Terzić Negra

    2010-01-01

    Full Text Available Introduction. Otosclerosis is an osteodystrophy disease of the bony labyrinth of the ear which leads to stapes fixation and to bradyecoia of a conductive type. The microsurgical treatment by the use of a stapes prosthesis provides hearing improvement and a reduction or disappearing of tinnitus. The aim of our study was to determine the hearing condition and tinnitus before and after the treatment of otosclerosis. Material and methods. A hundred patients with otosclerosis, aged 20 to 70, were surgically treated at the Otorhinolaryngology Clinic and the Functional Diagnostics, Military Medical Academy, Belgrade. After the treatment, the audiometric examinations were performed in order to assess the hearing condition and tinnitus was assessed by a questionnaire. The subjective assessment of tinnitus was ranged as present, reduced or absent. Results. Before the treatment, hearing impairment was present in all the patients, while tinnitus was found in 91% of them. One year following the surgical treatment hearing improvement was found in 96% of the patients, and tinnitus cessation in 89% of them. Conclusion. The surgical treatment can result in hearing improvement and cessation or reduction of tinnitus.

  7. The impact of the economic situation of the couples before and after divorce

    Directory of Open Access Journals (Sweden)

    Alketa Molla

    2015-07-01

    Full Text Available Divorce is not just a problem caused by social, but also economic consequences. Social implications are vital and cannot be overlooked. It is not easy to bring up children nowadays, even if both parents are employed and contribute both economically for their welfare. There are more difficulties for divorced parents, who are forced to make such a task. It is very difficult for this category to provide good living conditions for children, especially when they do not have a house to live, when they are unemployed, or in the cases when the other parent does not contribute economically. Often parents of divorced couples provide shelter and help, but this is not enough. Many divorced parents choose another country to ensure better living conditions for their children. Main objective of this article is to present the economic situation in which couples were before and after the divorce. The survey data are taken from the personal data of divorced from the Albanian Court of Elbasan.

  8. Evaluation of Serum Zinc Levels in Hyperbilirubinemic Neonates Before and After Phototherapy

    Directory of Open Access Journals (Sweden)

    Ziba Mosayebi

    2016-03-01

    Full Text Available Background The existing therapeutic methods for neonatal jaundice are costly, time-consuming and potentially risky. Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine (bilirubin and zinc can form a complex in physiologic pH; however, zinc toxicity is an issue that must be considered since theoretically bilirubin reduction by phototherapy may increase serum zinc levels, making additional zinc supplementation the potential cause of zinc toxicity. Objectives So, our purpose was evaluating the serum zinc level alterations before and after phototherapy, in hyperbilirubinemic newborns. Materials and Methods A prospective cohort study was performed at the children’s medical center of Tehran University of Medical Sciences from 2012 to 2014. Healthy, full-term exclusively breast fed newborns with non-hemolytic jaundice were enrolled in the study. Participants were divided into two groups based on serum bilirubin levels (TSB 200 in only neonates with severe hyperbilirubinemia. Conclusions Phototherapy increases serum zinc level by reducing bilirubin level so that additional supplementation of this element can lead potentially to zinc toxicity.

  9. MRI of the knee before and after arthroscopic synovectomy in patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    The effectiveness of arthroscopic synovectomy (A-S) for the knee of rheumatoid arthritis (RA) patients was assessed by comparing the severity of synovial proliferation on MRI before and after the surgery. Twenty-five patients (30 knees) were studied. The mean duration of RA was 6 years and 7 months and the mean age at the time of A-S was 49.0 years. The mean follow-up period was 19 months (range: 6-39 months). The preoperative Larsen's classification from grade I to IV was 8, 13, 6, and 3 knees, respectively. Synovial proliferation was evaluated by the modified Takeuchi's classification (MRI score). The MRI score was investigated in relationships with the radiographic grade, wet weight of excised tissue, treatment score for RA knees of the Japanese Orthopaedic Association (JOA score), and the CRP value. The MRI score, JOA score, and CRP all significantly improved during follow-up. The radiographic grade showed less progression, the JOA score improved more, and CRP was lower during follow-up in patients with a postoperative MRI score less than 5. The wet weight of excised tissue showed no related with the MRI score. These results suggest that the effectiveness of A-S can be determined by evaluation of improvement of the MRI score. (author)

  10. Analysis of Water Properties and Geostrophic Currents in Fiji Waters Before and After Tropical Cyclone Gene

    Directory of Open Access Journals (Sweden)

    Shivneel Prasad

    2009-01-01

    Full Text Available Problem statement: Water properties influence ocean primary production and drive the ocean food chain. This study depicts changes in temperature and salinity and its effects on geostrophic currents near Fiji before and after Tropical Cyclone (TC Gene. Approach: Available Argo float data from 6 January-4 February 2008 were used for analysis since TC Gene passed the area on 28 January 2008. The dynamic height and geostrophic current data were obtained from the Aviso website. Results: The thermocline depth increased by 20 m after the cyclone. A temperature drop of approximately 3°C was also noticed in the study area. Using this drop in temperature, the heat energy removed by the cyclone was calculated to be 0.095 MWh m-2. Salinity profiles showed an increase of 0.42 psu to a depth of 35 m after the cyclone. Changes in salinity and temperature of water may also cause changes in the dynamic height and in turn the geostrophic current patterns. After plotting the geostrophic current vectors, it was observed that the current patterns changed significantly after TC gene. Seasonal changes were also evident before the cyclone. Conclusion/Recommendations: Although the lifespan of TC gene was short, its effect on the water properties near Fiji was significant as it completely changed the geostrophic current patterns and this can have a huge implication on marine life.

  11. Factors affecting isokinetic muscle strength before and after anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Yüksel, Halil Yalçin; Erkan, Serkan; Uzun, Macit

    2011-06-01

    The purpose of this study was to evaluate the factors affecting muscle strength of ACL-deficient knees before and after ACL reconstruction. The study included 122 male patients who underwent primary ACL reconstruction with a bone-patellar tendon-bone autograft. Preoperative loss and change in muscle strength in both extensor and flexor muscle groups after ACL reconstruction were calculated separately at 60 degrees/sec and 180 degrees/sec angular velocities. We evaluated the effect of surgical delay on the preoperative deficit and on its change after surgery. Muscle strength change after ACL reconstruction was also evaluated in relation to patient compliance to treatment. The longer the delay of ACL reconstruction the more the muscle strength deficit of flexor and extensor muscles increased. In the ACL deficient knees with high strength deficit, improvement in muscle strength was higher after ACL reconstruction for both muscle groups. When delay of ACL reconstruction was short and the patient was compliant to treatment, flexor muscle strength recovery was early. Shortening the delay to reconstruction had a positive influence on muscle strength after ACL reconstruction when preoperative muscle strength deficit was high. PMID:21846002

  12. MR venography in cervical myelopathy before and after direct skull traction

    International Nuclear Information System (INIS)

    MR venography (MRV) was performed to evaluate the anterior cervical venous plexuses in five normal volunteers and eight patients with cervical myelopathy before and after direct skull traction. Visibility of the plexuses from C2 to C7 was evaluated and scored by five observers in those groups. The venography was performed with FISP sequences (fast imaging with steady state precession) and with the injection of Gd-derivatives. The MRV was obtained after maximum-intensity projection and 3D reconstruction. In the normal volunteers, the internal vertebral plexus (IVP), intervertebral vein (IV) and anastomotic vein (AV) were all well demonstrated. In the patients, those plexuses were less well demonstrated in comparison with the normal volunteer, particularly in C5 which is the most frequently affected area. The patient group had lower scores than the normal group. However, the score at C5 was not lower than those at non-affected sites. After treatment, MRV demonstrated those plexuses better in some cases of cervical myelopathy; although this was not evaluated statistically. (author)

  13. MR venography in cervical myelopathy before and after direct skull traction

    Energy Technology Data Exchange (ETDEWEB)

    Sekiguchi, Akira; Enomoto, Kyoko; Kato, Hiroshi [Saitama Medical School, Moroyama (Japan)

    1999-01-01

    MR venography (MRV) was performed to evaluate the anterior cervical venous plexuses in five normal volunteers and eight patients with cervical myelopathy before and after direct skull traction. Visibility of the plexuses from C2 to C7 was evaluated and scored by five observers in those groups. The venography was performed with FISP sequences (fast imaging with steady state precession) and with the injection of Gd-derivatives. The MRV was obtained after maximum-intensity projection and 3D reconstruction. In the normal volunteers, the internal vertebral plexus (IVP), intervertebral vein (IV) and anastomotic vein (AV) were all well demonstrated. In the patients, those plexuses were less well demonstrated in comparison with the normal volunteer, particularly in C5 which is the most frequently affected area. The patient group had lower scores than the normal group. However, the score at C5 was not lower than those at non-affected sites. After treatment, MRV demonstrated those plexuses better in some cases of cervical myelopathy; although this was not evaluated statistically. (author)

  14. Tc1 Cells Percentage in Patients with Cutaneous Leishmaniasis before and after Treatment with Glucantime

    Directory of Open Access Journals (Sweden)

    M Mohajery

    2007-05-01

    Full Text Available Background: Various responses and different prognosis to specific treatment in different patients from one hand, and importance of IFN-γ producer cells on the other hand impressed us to study Tc1. Methods: The study was conducted in Ghaem Medical Center and Bu-Ali Research Institute, Mashhad University of Medical Sciences, Iran from 2001 to 2002. Lymphocytes of 36 patients were counted and cultured. Percentage of different responsible immunity cells in 29 patients, were determined by Flow Cytometry System before and after medication with glucantime (IM. Patients who showed improvement after the treatment were put into group 1 and those who did not recover were labeled group 2. In this self-control clinical trial, sampling method was consecutive non-probability and the results were analyzed by t-test consequently. Results: The percentage of Tc1 cells showed a significant increase despite of being stimulated with Phorpol-Mristate-Acetate (PMA among the whole studied patients and group 1 (P= 0.069 and P= 0.040, respectively. While no significant change was observed among patients in group 2. Conclusion: This verifies the influence of Tc1 cells for the treatment of patients with CL and perhaps the role of glucantime in improving the cell immunity response through increasing such cells.

  15. Chemical Bonding States of TiC Films before and after Hydrogen Ion Irradiation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    TiC films deposited by rf magnetron sputtering followed by Ar+ ion bombardment were irradiated with a hydrogen ion beam. X-ray photoelectron spectroscopy (XPS) was used for characterization of the chemical bonding states of C and Ti elements of the TiC films before and after hydrogen ion irradiation, in order to understand the effect of hydrogen ion irradiation on the films and to study the mechanism of hydrogen resistance of TiC films. Conclusions can be drawn that ion bombardment at moderate energy can cause preferential physical sputtering of carbon atoms from the surface of low atomic number (Z) material. This means that ion beam bombardment leads to the formation of a non-stoichiometric composition of TiC on the surface.TiC films prepared by ion beam mixing have the more excellent characteristic of hydrogen resistance. One important cause, in addition to TiC itself, is that there are many vacant sites in TiC created by ion beam mixing.These defects can easily trap hydrogen and effectively enhance the effect of hydrogen resistance.

  16. Australians' views on carbon pricing before and after the 2013 federal election

    Science.gov (United States)

    Dreyer, Stacia J.; Walker, Iain; McCoy, Shannon K.; Teisl, Mario F.

    2015-12-01

    As climate policies change through the legislative process, public attitudes towards them may change as well. Therefore, it is important to assess how people accept and support controversial climate policies as the policies change over time. Policy acceptance is a positive evaluation of, or attitude towards, an existing policy; policy support adds an active behavioural component. Acceptance does not necessarily lead to support. We conducted a national survey of Australian residents to investigate acceptance of, and support for, the Australian carbon pricing policy before and after the 2013 federal election, and how perceptions of the policy, economic ideology, and voting behaviour affect acceptance and support. We found acceptance and support were stable across the election period, which was surprising given that climate policy was highly contentious during the election. Policy acceptance was higher than policy support at both times and acceptance was a necessary but insufficient condition of support. We conclude that acceptance is an important process through which perceptions of the policy and economic ideology influence support. Therefore, future climate policy research needs to distinguish between acceptance and support to better understand this process, and to better measure these concepts.

  17. Anthropometric Measures and Fasting Insulin Levels in Children Before and after Cure of Cushing syndrome

    Science.gov (United States)

    Keil, Margaret F; Graf, Jennifer; Gokarn, Nirmal; Stratakis, Constantine A

    2011-01-01

    Background & Aims Children with Cushing syndrome present with growth delay and excess adiposity that tends to be generalized rather than centripetal. There are no prospective studies of this phenotype as it evolves before and after treatment in children. The aims of this study were to evaluate children prior to and one-year after surgical cure compared to controls and to determine fasting insulin levels and their possible association with waist circumference and waist-height ratio, pre- and post-cure of Cushing syndrome. Methods 30 children with Cushing syndrome were evaluated prior to and one-year post-treatment and compared to 14 age and body mass index-matched controls. Results Only triceps skin fold z- score showed a significant difference between patients with active Cushing syndrome and controls. A positive correlation between fasting insulin levels and waist circumference z- score was found for children with Cushing syndrome; this association persisted one-year following cure. Conclusions Unlike adults affected with Cushing syndrome, upper arm muscle area of children with Cushing syndrome did not differ from obese children without Cushing syndrome. The persistence of a positive correlation between waist circumference and fasting insulin despite remission of Cushing syndrome suggests that children with a history of Cushing syndrome may have an increased risk for adverse long-term effects of increased abdominal fat mass. Clinical Trial numbers: NCT00001595, NCT00001452, NCT00005927 PMID:22154461

  18. [Change trend of vegetation cover in Beijing metropolitan region before and after the 2008 Olympics].

    Science.gov (United States)

    Sun, Xiao-Peng; Wang, Tian-Ming; Wu, Jian-Guo; Ge, Jian-Ping

    2012-11-01

    The MODIS-NDVI data from 2000 to 2009 were used to analyze the temporal dynamics and spatial distribution of the vegetation cover in the Beijing metropolitan region before and after the 2008 Olympics. During the study period, the proportion of the significantly increased pixels of NDVI occupied 20.7% while that of the significantly decreased pixels only occupied 4.1% of the total, and the decreasing rate of the NDVI was slightly faster than the increasing rate. The significant changes of the NDVI were mainly concentrated in the low altitude and small slope areas with intensive human activities, and two bands were formed in the plain area, i. e., the vegetation increasing band within the 5th Ring Road and the vegetation decreasing band from the 5th Ring Road to the outside areas of the 6th Ring Road. In the areas with significant vegetation change, there was an obvious transition between the high and low NDVI sections but less change in the medium NDVI section, mainly due to the conversion of land cover type. In the Capital function core area and ecological conservation zones, vegetation change represented a positive trend; while in the urban function expansion area and urban development area, vegetation change had the dual characteristics of both positive and negative trends. A series of ecological engineering projects during the preparatory period of the 2008 Olympics was the main cause of the vegetation increase in the study area.

  19. Examining endothelial function and platelet reactivity in patients with depression before and after SSRI therapy

    Directory of Open Access Journals (Sweden)

    Tye eDawood

    2016-02-01

    Full Text Available While it is recognised that patients with major depressive disorder (MDD are at increased risk of developing cardiovascular disease (CVD the mechanisms responsible remain unknown. Endothelial dysfunction is one of the first signs of CVD. Using two techniques, flow mediated dilatation in response to reactive hyperaemia and laser Doppler velocimetry with iontophoresis, we examined endothelial function in the forearm before and after SSRI treatment in 31 patients with MDD. Measurement of intercellular adhesion molecule-1 (ICAM-1, vascular cell adhesion molecule-1, soluble P-selectin and noradrenaline in plasma was also performed. Prior to treatment, markers of endothelial and vascular function and platelet reactivity were within the normal range. Following SSRI therapy (95 ± 5 days symptoms of depression were reduced (paired difference between pre and post treatment Hamilton rating -18 ± 1, P<0.001 with 19 patients recovered and 4 remitted. There occurred no significant change in markers of endothelial or vascular function following SSRI therapy. The improvement in Hamilton depression rating in response to therapy could be independently predicted by the baseline arterial plasma noradrenaline concentration (r2 = 0.36, P=0.003. In this cohort of patients with MDD SSRI therapy did not influence endothelial function or markers of vascular or platelet reactivity. Patient response to SSRI therapy could be predicted by the initial circulating level of noradrenaline, with noradrenaline levels being lower in responders.

  20. Mechanical and structural characterization of tibial prosthetic interfaces before and after aging under simulated service conditions.

    Science.gov (United States)

    Cavaco, A; Ramalho, A; Pais, S; Durães, L

    2015-03-01

    Prosthesis interface is one of the most important components to promote individual׳s health and comfort, as it establishes direct contact with the skin and transfers loads generated during gait. The aim of this study was to mechanically characterize, three commercial interfaces (block copolymer, silicone gel and silicone elestomer), under static and dynamic conditions, before and after undergoing a process of chemical aging in synthetic sweat for periods up to 90 days. Static mechanical compression tests were performed on the materials, as well as fatigue tests to assess their static and dynamic mechanical behaviors, respectively. For the second, a sinusoidal load was applied with an appropriate range of deformation for each material. Several analytical techniques were also used to characterize the materials, namely Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), and morphology characterization by Scanning Electron Microscopy (SEM). All the tested materials have strong viscoelastic behavior, showing a linear response for small deformations, followed by a nonlinear behavior for higher deformation. The block copolymer and the silicone gel are affected by aging in synthetic sweat in a similar way, with a significant increase of their rigidity after 30 days, followed by a progressive reduction. The silicone elastomer displays a continuous increase of rigidity along the 90 days of storage, being the most sensitive to aging affects. It also exhibits the lowest stiffness value, being suitable for uses that require maximum comfort. All materials demonstrate chemical and structural stability under service simulated conditions. PMID:25554916

  1. Comparison of CT numbers of organs before and after plastination using standard S-10 technique.

    Science.gov (United States)

    Shanthi, Pauline; Singh, Rabi Raja; Gibikote, Sridhar; Rabi, Suganthy

    2015-05-01

    Plastination is the art of preserving biological tissues with curable polymers. Imaging with plastinates offers a unique opportunity for radiographic, anatomical, pathological correlation to elucidate complex anatomical relationships. The aim of this study was to make plastinates from cadavers using the standard S-10 plastination technique and to compare the radiological properties of the tissue before and afterwards to examine the suitability of plastinates as phantoms for planning radiotherapy treatment. An above-diaphragm and a below-diaphragm specimen were obtained from a male and a female cadaver, respectively, and subjected to the standard S-10 plastination technique. CT images were obtained before and after plastination and were compared using Treatment Planning System for anatomical accuracy, volume of organs, and CT numbers. The plastinated specimens obtained were dry, robust, and durable. CT imaging of the plastinated specimens showed better anatomical detail of the organs than the preplastinate. Organ volumes were estimated by contouring the organs' outline in the CT images of the preplastinated and postplastinated specimens, revealing an average shrinkage of 25%. CT numbers were higher in the plastinated specimens except in bones and air-filled cavities such as the maxillary air sinus. Although plastination by the standard S-10 technique preserves anatomical accuracy, it increases the CT numbers of the organs because of the density of silicone, making it unsuitable for radiation dosimetry. Further improvements of the technique could yield more suitable plastinated phantoms. PMID:25708008

  2. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment.

    Directory of Open Access Journals (Sweden)

    Ingrid Arijs

    Full Text Available BACKGROUND: Antimicrobial peptides (AMPs protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD, but it is not clear whether this is a primary defect. We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD. METHODOLOGY/PRINCIPAL FINDINGS: Mucosal gene expression of 81 AMPs was assessed in 61 IBD patients before and 4-6 weeks after their first infliximab infusion and in 12 control patients, using Affymetrix arrays. Quantitative real-time reverse-transcription PCR and immunohistochemistry were used to confirm microarray data. The dysregulation of many AMPs in colonic IBD in comparison with control colons was widely restored by infliximab therapy, and only DEFB1 expression remained significantly decreased after therapy in the colonic mucosa of IBD responders to infliximab. In ileal Crohn's disease (CD, expression of two neuropeptides with antimicrobial activity, PYY and CHGB, was significantly decreased before therapy compared to control ileums, and ileal PYY expression remained significantly decreased after therapy in CD responders. Expression of the downregulated AMPs before and after treatment (DEFB1 and PYY correlated with villin 1 expression, a gut epithelial cell marker, indicating that the decrease is a consequence of epithelial damage. CONCLUSIONS/SIGNIFICANCE: Our study shows that the dysregulation of AMPs in IBD mucosa is the consequence of inflammation, but may be responsible for perpetuation of inflammation due to ineffective clearance of microorganisms.

  3. Santorinicele: secretin-enhanced magnetic resonance cholangiopancreatography findings before and after minor papilla sphincterotomy

    Energy Technology Data Exchange (ETDEWEB)

    Boninsegna, Enrico; Manfredi, Riccardo; Ventriglia, Anna; Negrelli, Riccardo; Pedrinolla, Beatrice; Mehrabi, Sara; Pozzi Mucelli, Roberto [University of Verona, Department of Radiology - Policlinico G.B. Rossi, Verona (Italy); Gabbrielli, Armando [University of Verona, Department of Medicine - Policlinico G.B. Rossi, Verona (Italy)

    2015-08-15

    To evaluate secretin-enhanced MRCP (S-MRCP) findings of patients with pancreas divisum and Santorinicele, before and after minor papilla sphincterotomy. S-MRCP examinations of 519 patients with suspected pancreatic disease were included. Size of the main pancreatic duct, presence and calibre of Santorinicele were evaluated. Duodenal filling was assessed on dynamic images. After sphincterotomy the same parameters and the clinical findings were re-evaluated. Pancreas divisum was depicted in 55/519 patients (11 %) by MRCP and an additional 26/519 by S-MRCP (total 81/519, 16 %). Santorinicele was detected in 7/81 patients (8.6 %) with pancreas divisum by MRCP and an additional 20/81 by S-MRCP (total 27/81, 33 %). Dorsal duct in patients with Santorinicele was significantly larger in the head compared with patients with only pancreas divisum (p < 0.01), in basal conditions (average 2.4 versus 1.9 mm) and after secretin administration (average 3.0 versus 2.4 mm). Duodenal filling was impaired in 11/27 patients (41 %) with Santorinicele. After sphincterotomy significant reduction in size of Santorinicele (-33 %) and dorsal duct (-17 %), increase of pancreatic juice and symptoms improvement were observed. Secretin administration increases the accuracy of MRCP in detecting Santorinicele and demonstrates the impaired duodenal filling. S-MRCP is useful to assess results of sphincterotomy. (orig.)

  4. Lattice defects in V–Ti BCC alloys before and after hydrogenation

    Energy Technology Data Exchange (ETDEWEB)

    Matsuda, Junko, E-mail: junko.matsuda@i2cner.kyushu-u.ac.jp [International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan); Akiba, Etsuo [International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan); Department of Mechanical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan)

    2013-12-25

    Highlights: •Strain contrast with spacing smaller than 20 nm is observed in as-cast and hydrogenated V–Ti alloys. •Twin boundaries and stacking faults are introduced into the V–Ti alloys after hydrogenation. •These planar defects are formed due to accommodation of shear stress during hydrogenation. •Densities of twin boundaries are higher in the alloys with smaller contents of V. •Effective absorbing capacities at ambient condition depend on the densities of twin boundaries. -- Abstract: Microstructures of V–Ti BCC alloys before and after hydrogenation/dehydrogenation are investigated using transmission electron microscopy. Strain contrast with spacing smaller than 20 nm is observed both in the as-cast alloys and hydrogenated alloys. Twin boundaries and stacking faults with spacing of 5–20 nm are introduced into the V–Ti BCC alloys after hydrogenation. These are parallel to {11"¯1} planes of FCC hydrides. The twin boundaries and stacking faults are formed due to the accommodation of shear stress during hydrogenation accompanied by large anisotropic expansion along the c-axis direction in V–Ti BCC alloys. Density of twin boundaries is high in the alloys with small contents of V, which have a small effective hydrogen capacity at ambient condition. Dependence of microstructure evolution in the V–Ti alloys during hydrogenation on the V/Ti ratio is also discussed with the thermodynamic stabilities from measurements of Pressure–Composition isotherms and mechanical properties.

  5. Variability of isolated colonies in bean nodulating Rhizobium strains before and after exposure to high temperature

    Directory of Open Access Journals (Sweden)

    Raposeiras Rui

    2002-01-01

    Full Text Available Irregular response to bean plants to Rhizobium inoculation has been attributed to among other factors, low competitive ability, low N2 fixation efficiency and genetic instability of the symbiont. This genetic instability caused by high rates of genomic rearrangements and/or plasmid deletions can be accentuated by high temperatures. This fact may limit the utilization of these strains as inoculants, especially in tropical soils. In this study, the variability of isolated colonies derived from effective R. leguminosarum bv. phaseoli (SLP1.3 and BR 10.026 and R tropici (SLA2.2 and BR322 strains was evaluated before and after exposure to high temperatures (four consecutive thermal shocks at 45masculineC. This evaluation involved plant dry matter analysis of inoculated plants and genotypic (plasmid profile and genomic patterns via RAPD analysis of the Rhizobium strains. The results evidenced that high temperature improve the natural performance variability especially between isolated colonies from R. leguminosarum bv. phaseoli strains. The plasmid profile of isolated colonies from R. tropici strains were identical regardless of temperature treatment whereas isolated colonies from R. leguminosarum bv. phaseoli alterations were detected especially after the thermal treatment. The genomic patterns generated by AP-PCR showed more alterations and genetic variation in isolated colonies from R. leguminosarum bv. phaseoli strains indicating that R. tropici strains are more stable and lower affected by high temperature.

  6. Orbito-frontal cortex and thalamus volumes in obsessive-compulsive disorder before and after pharmacotherapy.

    Science.gov (United States)

    Atmaca, Murad; Mermi, Osman; Yildirim, Hanefi; Gurok, M Gurkan

    2016-09-01

    In the present study, we focused on the key brain regions, OFC and thalamus, to investigate the roles of antiobsessional agents on volume changes of these brain regions after 12 weeks of anti-obsessional treatment in patients with obsessive-compulsive disorder (OCD). Fourteen patients with OCD and the same number of healthy controls were included in the study. At baseline, the volumes of the OFC and thalamus were compared by using magnetic resonance imaging (MRI) between groups. The volumes of OFC and thalamus were evaluated before and after the anti-obsessional drug treatment solely in the patient group. Our study revealed that thalamus volumes were reduced statistically significantly throughout the treatment period. However, we found that OFC volumes did not change statistically significantly throughout the treatment period. In summary, our study found that anti-obsessional drug treatment had an effect on thalamus volumes throughout the treatment period for both sides but not on OFC volumes. However, future studies with larger sample are required. PMID:26311393

  7. COMPARATIVE STUDY OF EMOTIONAL DISORDERS STRUCTURE IN PATIENTS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    T. G. Mikhaylichenko

    2011-01-01

    Full Text Available Being based on a private experience, authors considered necessary to study features of emotional disorders that will allow understanding the mechanism of mental adaptation to disease at patients before and after OLT. In comparative research of structure of emotional frustration at the patients making the most numerous groups of patients before transplantation of a liver (viral hepatitis and autoimmune liver diseases, 129 persons, from them 75 before OLT are included at entering into a waiting list and 54 to through 22 ± 9 days after OLT. Distinctions in structure of emotional frustration are revealed: at patients with autoimmune liver diseases be- fore OLT and viral hepatitis after OLT the semiology combined with disturbing-depressive experiences and hypochondriac fixings is brightly expressed neurotic, them distinguishes high level of personal uneasiness. For patients with autoimmune liver diseases after OLT and viral hepatitis before OLT are characteristic moderately expressed neurotic frustration of an asthenia circle and low level of personal and situational anxiety. 

  8. Correlation between cerebral oxygen metabolism and cerebral blood flow simultaneously measured before and after acetazolamide administration

    Science.gov (United States)

    Yamaguchi, Hiroichiro; Yamauchi, Hideto; Hazama, Shiro; Hamamoto, Hirotsugu; Inoue, Nobuhiro

    1999-10-01

    The cerebral circulation and metabolism of ten preoperative cardiac surgery patients were assessed. Alterations in regional cerebral blood flow (rCBF), measured by 123I-N- isopropyl-p-iodo-amphetamine single-photon emission computed tomography, and in cerebral oxygen metabolism, simultaneously detected by near-infrared spectroscopy (NIRS) before and after acetazolamide administration, were investigated. The rCBF (ml/min/100 g) increased significantly from 40.21 +/- 7.65 to 56.24 +/- 13.69 (p equals 0.001), and a significant increase in oxyhemoglobin (Oxy-Hb) of 13.9% (p equals 0.0022) and total hemoglobin (Total-Hb) of 5.7% (0.0047) along with a significant decrease in deoxyhemoglobin (Deoxy-Hb) of 8.9% (p equals 0.0414) were observed concomitantly. Thus, the Oxy-Hb/Total- Hb ratio (%Oxy-Hb) rose significantly from 67.26 +/- 9.82% to 72.98 +/- 8.09% (p equals 0.0022). Examination of the relationships between individual parameters showed that the percentage changes in rCBF and Oxy-Hb were significantly correlated (r equals 0.758, p equals 0.011). The percentage changes in rCBF and %Oxy-Hb were also correlated significantly (r equals 0.740, p equals 0.014). In conclusion, this evidence suggested that NIRS is able to detect relative changes in cerebral hemodynamics and reflect luxury perfusion induced by acetazolamide.

  9. Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction.

    Science.gov (United States)

    Aalbers, R; de Monchy, J G; Kauffman, H F; Smith, M; Hoekstra, Y; Vrugt, B; Timens, W

    1993-06-01

    We wanted to determine whether changes in bronchial hyperresponsiveness (BHR) following allergen challenge show a time relationship with inflammatory events in the airways of allergic asthmatic subjects. Lavage was performed and endobronchial biopsies were taken via the fiberoptic bronchoscope, before, and 3 and 24 h after, allergen challenge, on separate occasions, in nine dual asthmatic responders. The numbers of activated eosinophils, identified by immunohistochemistry, using the monoclonal anti-eosinophil cationic protein antibody, EG2, were significantly increased both at 3 h and at 24 h in the submucosa and bronchial lavage. A significant negative correlation was found between the number of EG2+ cells in the submucosa and in the bronchial lavage 24 h after the allergen challenge (r = -0.70). At 24 h, the amount of eosinophil cationic protein (ECP) was increased in the bronchial lavage. A significant correlation was observed between the amount of ECP at 3 h and the log provocative dose of house dust mite producing a 20% fall in forced expiratory volume in one second (PD20 HDM) (r = -0.63). The results suggest a recruitment of activated eosinophils to the submucosa and, further, to the epithelial lining, followed by degranulation. This process has already started 3 h after allergen challenge, and lasts for at least 24 h, which may result in mucosal damage and subsequent allergen-induced increase in BHR, before and after the late asthmatic reaction. PMID:8339804

  10. Life quality of low-vision elderly people: before and after hearing and speech intervention

    Directory of Open Access Journals (Sweden)

    Mayla Myrina Bianchim Monteiro

    2015-08-01

    Full Text Available ABSTRACT Aim: To evaluate life quality of elderly people with acquired low vision before and after hearing and speech intervention. Methods: This was a descriptive cross-sectional study. The study was made with 52 elderly people with acquired low vision. Two questionnaires that measures life quality were used in this study. The first was ‘Low Quality of Life Vision (LVQOL’ and the second the ‘National Eye Institute Visual Function Questionnaire (NEIVFQ-25’. The study included people with more than 60 years with acquired low vision and who accepted to participate signing the consent form. The hearing and speech therapy were made into three months, one meeting a week. The questionnaires were applied in the first and last day of the intervention. Results: The age ranged between 60 and 91 years. The macular disorder (38%, such as age-related macular degeneration, macular hole and high myopia were the main causes of visual loss. Although the tests show superior performance after the intervention, there was no statistically significant difference. On the question about difficulties seeing in general, 17 participants answered that they had much more difficulty before the intervention and only 5 participants have reported having much difficulty after the intervention. Conclusion: The intervention trended to positive results, and after the meetings, participants showed improvements in aspects of the two questionnaires used in the study, decreasing the degree of difficulty in performing activities.

  11. Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

    Science.gov (United States)

    Schooneman, Marieke G; Napolitano, Antonella; Houten, Sander M; Ambler, Graeme K; Murgatroyd, Peter R; Miller, Sam R; Hollak, Carla E M; Tan, Chong Y; Virtue, Samuel; Vidal-Puig, Antonio; Nunez, Derek J; Soeters, Maarten R

    2016-09-15

    Acylcarnitines, fatty acid oxidation (FAO) intermediates, have been implicated in diet-induced insulin resistance and type 2 diabetes mellitus, as increased levels are found in obese insulin resistant humans. Moreover plasma acylcarnitines have been associated with clinical parameters related to glucose metabolism, such as fasting glucose levels and HbA1c. We hypothesized that plasma acylcarnitines would correlate with energy expenditure, insulin sensitivity and other clinical parameters before and during a weight loss intervention. We measured plasma acylcarnitines in 60 obese subjects before and after a 12 week weight loss intervention. These samples originated from three different interventions (diet alone (n = 20); diet and exercise (n = 21); diet and drug treatment (n = 19)). Acylcarnitine profiles were analysed in relation to clinical parameters of glucose metabolism, insulin sensitivity and energy expenditure. Conclusions were drawn from all 60 subjects together. Despite amelioration of HOMA-IR, plasma acylcarnitines levels increased during weight loss. HOMA-IR, energy expenditure and respiratory exchange ratio were not related to plasma acylcarnitines. However non-esterified fatty acids correlated strongly with several acylcarnitines at baseline and during the weight loss intervention (p < 0.001). Acylcarnitines did not correlate with clinical parameters of glucose metabolism during weight loss, questioning their role in insulin resistance and type 2 diabetes mellitus. PMID:27444119

  12. Investigating shock-driven Richtmyer-Meshkov ripple evolution before and after re-shock

    Science.gov (United States)

    Nagel, S. R.; Huntington, C. M.; MacLaren, S. A.; Raman, K. S.; Baumann, T.; Benedetti, L. R.; Doane, D. M.; Islam, T. S.; Felker, S.; Holder, J. P.; Seugling, R. M.; Wang, P.; Zhou, Y. K.; Doss, F. W.; Flippo, K. A.; Perry, T. S.

    2015-11-01

    Late-time Rayleigh-Taylor/Richtmyer-Meshkov(RM) ripple growth in an opposing-shock geometry is investigated using x-ray area backlit imaging of a shock-tube with indirectly driven shocks. The shocks are driven from opposing sides of the tube. The ablator layer on one side has pre-imposed ripples in the form of a sine wave with two amplitudes and a single wavelength. This ablator includes an opaque tracer layer that is used to track the perturbed interface as it is driven into a lower density foam. The ablator on the opposing side of the tube is flat, and is used to launch the shock that re-shocks the rippled interface. A large-area backlighter and gated x-ray radiography is used to capture images at different times during the RM instability growth. Here, first measurements obtained with this experimental platform at the NIF, including the optimization of the platform are presented. The RM ripple evolution before and after re-shock, including a possible loss of initial conditions are, also discussed. The data that informs the codes is compared to simulation results Work supported by U.S. Department of Energy under Contract DE- AC52-06NA27279. LLNL-ABS-674941.

  13. Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression

    Directory of Open Access Journals (Sweden)

    Rui Yang

    2014-01-01

    Full Text Available Sertraline, one of the oldest antidepressants, remains to be the most efficacious treatment for depression. However, major depression disorder (MDD is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive hypothalamus activity. The purpose of this study was to examine the effects of antidepressant treatment (sertraline on hypothalamus-anchored resting brain circuitry. Functional magnetic resonance imaging was conducted on depressed patients (n=12 both before and after antidepressant treatment. After eight weeks of antidepressant treatment, patients with depression showed significantly increased connectivity between the hypothalamus and dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, insula, putamen, caudate, and claustrum. By contrast, decreased connectivity of the hypothalamus-related areas was primarily located in the inferior frontal gyrus, medial frontal gyrus, cingulated gyrus, precuneus, thalamus, and cerebellum. After eight weeks of antidepressant therapy, 8 out of the 12 depressed subjects achieved 70% reduction or better in depressive symptoms, as measured on the Hamilton depression rating scale. Our findings may infer that antidepressant treatment can alter the functional connectivity of the hypothalamus resting brain to achieve its therapeutic effect.

  14. The function of the intestinal microflora in patients with ulcerative colitis before and after colectomy.

    Science.gov (United States)

    Leijonmarck, C E; Benno, P; Carlstedt-Duke, B; Monsen, U; Norin, E; Poppen, B; Saxerholt, H; Midtvedt, T

    1990-06-01

    The function of the intestinal microflora was studied in patients with ulcerative colitis before and after colectomy. The following six microflora-associated characteristics (MACs) were investigated: formation of coprostanol and urobilinogen; degradation of mucin, water-soluble protein, and beta-aspartylglycine; and presence of faecal tryptic activity. In 12 unoperated patients without sulphasalazine as maintenance therapy the six MACs were similar to those in normal subjects. In 12 unoperated patients receiving sulphasalazine the formation of coprostanol and urobilinogen was significantly lower (p less than 0.01 and p less than 0.001, respectively) and the level of faecal tryptic activity was significantly higher (p less than 0.01) than in normal subjects. The functional capacity of the microflora in operated patients treated by colectomy combined with one of four surgical procedures (ileorectal anastomosis, ileoanal anastomosis with pelvic pouch, Kock's continent ileostomy, or conventional ileostomy) was disturbed with regard to all six MACs. The disturbance was most pronounced in patients with conventional ileostomy. PMID:1972811

  15. Muscle strength and function before and after anterior cruciate ligament reconstruction using semitendonosus and gracilis.

    Science.gov (United States)

    Keays, S L; Bullock-Saxton, J; Keays, A C; Newcombe, P

    2001-10-01

    This study assessed the quadriceps and hamstring strength before and 6 months after anterior cruciate ligament (ACL) reconstructive surgery using the hamstrings and related the findings to functional performance. Six months after surgery is a critical time for assessment as this is when players are returning to sport. Maximum isokinetic strength of 31 patients with complete unilateral ACL ruptures was measured at speeds of 60 degrees and 120 degrees per second. Functional assessment included the single hop, the triple hop, the shuttle run, side-step and carioca tests. All patients underwent a controlled quadriceps emphasized home-based physiotherapy program both before and after surgery. Results show that before surgery there was a 7.3% quadriceps strength deficit at 60 degrees per second compared to the uninjured leg but no hamstring strength deficit. After surgery there was a statistically significant but relatively small loss of muscle strength. The quadriceps strength deficit had increased to 12% and there was a 10% hamstring deficit. Post-operatively there was an 11% and 6.3% improvement in the hop tests, a 9% (P < 0.01) improvement in the shuttle run, a 15% (P < 0.001) improvement in the side step and a 24% (P < 0.001) improvement in the carioca tests (P < 0.001) despite the loss of muscle strength.

  16. Dioxin body burden among blood donors before and after the Belgian dioxin/PCB incident

    Energy Technology Data Exchange (ETDEWEB)

    Debacker, N.; Sasse, A.; Wouwe, N. Van; Windal, I.; Carbonnelle, S.; Overmeire, I. Van; Sartor, F.; Goeyens, L.; Oyen, H. Van [Scientific Inst. of Public Health, Brussels (Belgium); Eppe, G.; Xhrouet, C.; Pauw, E. De [Centre of Analysis of Residues in Traces, Luik (Belgium)

    2004-09-15

    In spring 1999, Belgium faced a severe food contamination when about 50 kg of PCBs containing 1 g of dioxins were introduced in the food chain. The possible public health impact of this food chain contamination was subject of a debate between different scientists. According to Vrijens et al. and Bernard et al. there was no significant public health impact, whereas van Larebeke et al. presumed the opposite claiming a significant increase of cancer incidence. These risk assessments were based on measurements of dioxins/PCBs in contaminated foods and nutritional habits observed in a selected group of adolescents (14-18 years old) using simulation techniques or on the estimation of the incremental cancer risk associated with the incremental levels of exposure to dioxins/PCBs during the incident. In the meantime, an epidemiological survey has been carried out in order to measure the dioxin levels in plasma samples collected before and after the incident. The aim of this paper is to report the preliminary results of this epidemiological survey.

  17. Positional variation of antipodal cells in polyembryonic rice ApⅢ before and after fertilization

    Institute of Scientific and Technical Information of China (English)

    YUAN Liangchen; CHEN Yongzhe; MU Xijin; LIN Jinxing

    2003-01-01

    The variation in the position of antipodal cells before and after fertilization in polyembryonic rice strain ApⅢ was studied by using conventional sectioning technique. It was shown that initially the three antipodal cells lie at the chalazal end of the young embryo sacs. Along with the development of embryo sac, the antipodal cells proliferate into a multicellular structure containing up to about 20 cells. Most of the cells migrate to its dorsal side when the embryo sacs turn into mature. In a few embryo sacs the antipodal cells are situated in the positions adjacent to the egg apparatus at the micropylar end, while in other sacs, they spread from the midst of the embryo sac to the micropylar end clinging to the nucellar tissue. Furthermore, it is reported for the first time that cells of some egg apparatus or proembryos disorganize when antipodal cells lie at the micropylar end, indicating that the function of the antipodal cells may vary during the embryogenesis in rice ApⅢ.

  18. On capital flows and macroeconomic performance: Evidence before and after the financial crisis in Turkey

    Directory of Open Access Journals (Sweden)

    Magda Kandil

    2015-12-01

    Full Text Available The paper sheds light on the Turkish experience of capital account liberalization and its effect on key macroeconomic variables, using quarterly data in a multivariate VAR model. We also take into consideration the crisis breakpoint in 2001 and estimate the effect of shocks attributed to capital flows, using quarterly data during the sub-periods 1989:01–2001:01 and 2001:02–2009:03. The findings indicate that capital flows have varying effects on the Turkish economy before and after the crisis in 2001 and the evidence supports significant effects of liberalizing financial flows on macroeconomic performance, especially during the post-crisis period (2001:02–2009:03. Moreover, this latter period exhibited evidence of sterilization policy that has helped mopping up excess liquidity and containing inflationary pressures. These factors seem to signal deliberate efforts by the Central Bank of Turkey to stem the risk of appreciation of the real exchange rate and preserve export competitiveness during periods of high financial inflows, a trend that has been reversed recently by the surge in outflows and currency depreciation in many emerging markets in anticipation of imminent normalization of monetary policy in the United States.

  19. Trends in breast cancer mortality in Sweden before and after implementation of mammography screening.

    Directory of Open Access Journals (Sweden)

    Jari Haukka

    Full Text Available BACKGROUND: Incidence-based mortality modelling comparing the risk of breast cancer death in screened and unscreened women in nine Swedish counties has suggested a 39% risk reduction in women 40 to 69 years old after introduction of mammography screening in the 1980s and 1990s. OBJECTIVE: We evaluated changes in breast cancer mortality in the same nine Swedish counties using a model approach based on official Swedish breast cancer mortality statistics, robust to effects of over-diagnosis and treatment changes. Using mortality data from the NordCan database from 1974 until 2003, we estimated the change in breast cancer mortality before and after introduction of mammography screening in at least the 13 years that followed screening start. RESULTS: Breast mortality decreased by 16% (95% CI: 9 to 22% in women 40 to 69, and by 11% (95% CI: 2 to 20% in women 40 to 79 years of age. DISCUSSION: Without individual data it is impossible to completely separate the effects of improved treatment and health service organisation from that of screening, which would bias our results in favour of screening. There will also be some contamination of post-screening mortality from breast cancer diagnosed prior to screening, beyond our attempts to adjust for delayed benefit. This would bias against screening. However, our estimates from publicly available data suggest considerably lower benefits than estimates based on comparison of screened versus non-screened women.

  20. Inflammation and Growth in Young Children with Obstructive Sleep Apnea Syndrome before and after Adenotonsillectomy

    Directory of Open Access Journals (Sweden)

    Yuval Nachalon

    2014-01-01

    Full Text Available Background. Obstructive sleep apnea (OSA is associated with growth impairment that usually improves following effective treatment. In this study we investigated the mechanisms underlying the growth processes in young children diagnosed with OSA, before and after adenotonsillectomy (T&A. Methods. Young children (6–36 months old were enrolled and evaluated before and several months after T&A surgery for height, weight, circulating high sensitive C-reactive protein (CRP, and insulin-like growth factor 1 (IGF-1 levels. Caloric intake was assessed by a validated Short Food Frequency Questionnaire (SFFQ. Results. Following T&A, children added 4.81 cm and 1.88 kg to their height and weight, respectively (P<0.001 for both and had a significant increase in BMI Z score (P=0.002. Increased caloric intake of 377 kcal/day was noted (P<0.001, with increased protein and decreased fat intake. The decrease in CRP levels correlated with the increase in body weight in boys (P<0.05, adjusted for caloric intake. Conclusions. Adenotonsillectomy results in enhanced somatic growth in young children that correlates with a decrease in systemic inflammation and caloric intake increment. Our findings imply that systemic inflammation may have an important role in this OSA-related morbidity.

  1. Electrocortical Dynamics in Children with a Language-Learning Impairment Before and After Audiovisual Training.

    Science.gov (United States)

    Heim, Sabine; Choudhury, Naseem; Benasich, April A

    2016-05-01

    Detecting and discriminating subtle and rapid sound changes in the speech environment is a fundamental prerequisite of language processing, and deficits in this ability have frequently been observed in individuals with language-learning impairments (LLI). One approach to studying associations between dysfunctional auditory dynamics and LLI, is to implement a training protocol tapping into this potential while quantifying pre- and post-intervention status. Event-related potentials (ERPs) are highly sensitive to the brain correlates of these dynamic changes and are therefore ideally suited for examining hypotheses regarding dysfunctional auditory processes. In this study, ERP measurements to rapid tone sequences (standard and deviant tone pairs) along with behavioral language testing were performed in 6- to 9-year-old LLI children (n = 21) before and after audiovisual training. A non-treatment group of children with typical language development (n = 12) was also assessed twice at a comparable time interval. The results indicated that the LLI group exhibited considerable gains on standardized measures of language. In terms of ERPs, we found evidence of changes in the LLI group specifically at the level of the P2 component, later than 250 ms after the onset of the second stimulus in the deviant tone pair. These changes suggested enhanced discrimination of deviant from standard tone sequences in widespread cortices, in LLI children after training. PMID:26671710

  2. Isokinetic Identification of Knee Joint Torques before and after Anterior Cruciate Ligament Reconstruction.

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    Adam Czaplicki

    Full Text Available The aim of this study was to evaluate the serial change of isokinetic muscle strength of the knees before and after anterior cruciate ligament reconstruction (ACLR in physically active males and to estimate the time of return to full physical fitness. Extension and flexion torques were measured for the injured and healthy limbs at two angular velocities approximately 1.5 months before the surgery and 3, 6, and 12 months after ACLR. Significant differences (p ≤ 0.05 in peak knee extension and flexion torques, hamstring/quadriceps (H/Q strength ratios, uninvolved/involved limb peak torque ratios, and the normalized work of these muscles between the four stages of rehabilitation were identified. Significant differences between extension peak torques for the injured and healthy limbs were also detected at all stages. The obtained results showed that 12 months of rehabilitation were insufficient for the involved knee joint to recover its strength to the level of strength of the uninvolved knee joint. The results helped to evaluate the progress of the rehabilitation and to implement necessary modifications optimizing the rehabilitation training program. The results of the study may also be used as referential data for physically active males of similar age.

  3. Isokinetic Identification of Knee Joint Torques before and after Anterior Cruciate Ligament Reconstruction.

    Science.gov (United States)

    Czaplicki, Adam; Jarocka, Marta; Walawski, Jacek

    2015-01-01

    The aim of this study was to evaluate the serial change of isokinetic muscle strength of the knees before and after anterior cruciate ligament reconstruction (ACLR) in physically active males and to estimate the time of return to full physical fitness. Extension and flexion torques were measured for the injured and healthy limbs at two angular velocities approximately 1.5 months before the surgery and 3, 6, and 12 months after ACLR. Significant differences (p ≤ 0.05) in peak knee extension and flexion torques, hamstring/quadriceps (H/Q) strength ratios, uninvolved/involved limb peak torque ratios, and the normalized work of these muscles between the four stages of rehabilitation were identified. Significant differences between extension peak torques for the injured and healthy limbs were also detected at all stages. The obtained results showed that 12 months of rehabilitation were insufficient for the involved knee joint to recover its strength to the level of strength of the uninvolved knee joint. The results helped to evaluate the progress of the rehabilitation and to implement necessary modifications optimizing the rehabilitation training program. The results of the study may also be used as referential data for physically active males of similar age.

  4. Occupational Stress and Mental Health of Employees of a Petrochemical Company before and after Privatization

    Directory of Open Access Journals (Sweden)

    A Mahdad

    2010-03-01

    Full Text Available Background: Many countries make many of their governmental sectors private. This transition, however, may affect their employees in numerous ways.Objective: To determine the level of occupational stress and mental health of employees of a petrochemical company in Isfahan, Central Iran, before and 3 months after privatization.Methods: Out of the 700 employees of the studied company, using a stratified random sampling technique, 140 persons were selected. We used Steinmetz occupational stress and GHQ-28 questionnaires to determine the level of stress and mental health status of participants.Results: The reliability of the questionnaires used was acceptable (Chronbach alpha coefficients: 0.85 and 0.86, respectively. Job stress level was significantly increased 3 months after privatization; the mean±SD job stress score before and after privatization were 22.9±10.43 and 28.3±12.25, respectively (p<0.001. The mean±SD mental health score after privatization (17.57±11.63 was also significantly (p<0.001 higher than that before the privatization (13.8±6.0. There was a significant (p<0.001 positive correlation between the mental health status score and job score (r=0.476.Conclusion: After privatization, the job stress of employees increased significantly. This increase was associated with a decrease in mental health. To lessen the side effects of privatization, the process should be performed cautiously.

  5. Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment

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    Reza M. Robati

    2013-01-01

    Full Text Available Background. Prolactin (PRL level is proposed to be associated with the severity of psoriasis although the previous studies reported different results. Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH, thyroid hormones (T3 and T4, and cortisol levels between patients with psoriasis and normal controls. Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI. Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline. Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3 and serum cortisol levels were observed after treatment (P<0.05, while the changes in other hormones were not significant. Conclusion. After treatment, PRL significantly decreased, and T3 and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed.

  6. Usefulness of {sup 99m}Tc-tetrofosmin myocardial scintigraphy before and after coronary intervention

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Itaru; Hou, Nobuyoshi; Komori, Tsuyoshi; Tabuchi, Koujiro; Matsui, Ritsuo; Sueyoshi, Kouzou; Narabayashi, Isamu; Matsuda, Shigeki; Tamoto, Shigemi [Osaka Medical Coll., Takatsuki (Japan)

    1997-06-01

    Dipyridamole-loading {sup 99m}Tc-tetrofosmin myocardial scintigraphy was performed for patients with coronary artery disease who underwent percutaneous transluminal coronary angiography (PTCA) in order to examine whether SPECT imaging prior to treatment is useful for the determination of prognosis after coronary intervention. Thirty-six patients including 9 with angina pectoris (AP), 22 with old myocardial infarction (OMI) and 5 OMI with AP were underwent dipyridamole-loading {sup 99m}Tc-tetrofosmin myocardial SPECT before and after coronary intervention. The length of follow-up was 185{+-}107 days after PTCA. Improvement of myocardial uptake was observed on myocardial SPECT in all cases with AP. Improvement of the myocardial uptake was observed 50% (4/8) of patients with OMI who had no myocardial viability. It was suggested that the improvement of myocardial uptake after PTCA was due to incomplete fill-in in cases with AP and that presence of fill-in was important for level of fill-in in patients with AP. The improvement of myocardial uptake in the scar tissue in patients with OMI contributed to the hibernating myocardium. We concluded that correct detection of hibernating myocardium was difficult despite the superior imaging capacity of {sup 99m}Tc-tetrofosmin myocardial SPECT. (author)

  7. STXM and NanoSIMS investigations on EPS fractions before and after adsorption to goethite.

    Science.gov (United States)

    Liu, Xinran; Eusterhues, Karin; Thieme, Jürgen; Ciobota, Valerian; Höschen, Carmen; Mueller, Carsten W; Küsel, Kirsten; Kögel-Knabner, Ingrid; Rösch, Petra; Popp, Jürgen; Totsche, Kai U

    2013-04-01

    Extracellular polymeric substances (EPS) are expected to be an important source for the formation of mineral-organic associations in soil. Because such formations affect the composition of mobile and immobile organic matter as well as the reactivity of minerals, we investigated the composition of EPS before and after adsorption to goethite. Raman measurements on EPS extracted from Bacillus subtilis distinguished four fractions rich in proteins, polysaccharides, lipids, or lipids and proteins. Scanning transmission X-ray microscopy identified three different EPS-fractions that varied in their composition in proteins, nonaromatic proteins, and polysaccharides. Reaction of EPS with goethite led to a preferential adsorption of lipids and proteins. The organic coverage was heterogeneous, consisting of ~100 × 200 nm large patches of either lipid-rich or protein-rich material. Nanoscale secondary ion mass spectrometry showed a strong S enrichment in aggregates of ~400 nm in the goethite adsorbed EPS. From our simplified model system, we learned that only a small portion (<10%) of EPS was immobilized via adsorption to goethite. This fraction formed a coating of subμm spaced protein-rich and lipid-rich domains, i.e., of two materials which will strongly differ in their reactive sites. This will finally affect further adsorption, the particle mobility and eventually also colloidal stability.

  8. COMPARISON OF LABOUR RELATIONS OF WORKERS OF FORMER TEKEL IN ADIYAMAN BEFORE AND AFTER ITS PRIVATIZATION

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    Gazanfer KAYA

    2015-12-01

    Full Text Available The Monopoly, Turkey's oldest and is a well-established as a public enterprises has a presence for many years. This business more tobacco production, has control processes related processing and selling. The Monopoly enterprises has become a major source of income for both agricultural producers and labor. In this article, before and after privatization labour relations of the Adiyaman the former Monopoly workers were examined in a comparative perspective. According to the findings of the study area; Adiyaman closure of the Monopoly, workers and their families, economic, social, and psychological extremely negative affect. Satisfaction from the current operating conditions is very low compared to the Monopoly period. Losses incurred in the period compared with the monopoly is the main reason for this dissatisfaction. When considering the intervening four years, more than half of the interviewees (62.8% were found to continue the difficulties of labor. The main difficulties of employees in the status of temporary staff, lacks a built of permanent jobs and they do not receive a wage to live a more humane.

  9. Occurrence of neuropathies in patients with severe heart failure before and after heart transplantation.

    Science.gov (United States)

    Bagnato, Sergio; Minà, Chiara; Sant'Angelo, Antonino; Boccagni, Cristina; Prestandrea, Caterina; Caronia, Alessandra; Clemenza, Francesco; Galardi, Giuseppe

    2016-03-01

    Neuropathies may affect heart reinnervation and functional outcome after heart transplantation (HT). In this study, neurological evaluations, standard nerve conduction studies, and electromyography were performed in 32 HT candidates without a previous history of neuromuscular disorder. Ten patients underwent HT and were revaluated 3 months later. We found that before HT 10 (31.3%) patients had sensorimotor polyneuropathy (18.8%) or sensory polyneuropathy (12.5%). After HT, the percentage of patients with a neuromuscular disorder increased to 70%, most of them showing new or worsening neuropathies or neuromyopathies. The most sensitive abnormality that indicated neuromuscular involvement after HT was a reduction of the compound muscle action potential (CMAP) of the deep peroneal nerve. In conclusion, neuromuscular disorders are common in HT candidates, and they further increase in occurrence after HT. A reduction of the deep peroneal nerve CMAP amplitude after HT may help to identify patients who need a more detailed neurophysiological evaluation. The diagnosis of neuromuscular disorders before and after HT may contribute to the development of more accurate therapeutic and rehabilitative strategies for these patients. PMID:26573590

  10. Medical Brain Drain in Romania: Trends before and after Accession to the European Union

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    Irina Boncea

    2013-05-01

    Full Text Available This article aims to identify the impact of Romania’s accession to the European Union on medical emigration, analyzing the evolution of the phenomenon before and after 2007. Prior work in this field consists in theoretical and qualitative studies, highlighting the push and pull factors contributing to the emigration of Romanian physicians, the impact and the possible measures. Emigration trends before integration are analyzed using a data set existing in the literature. For the following period, between 2007 and 2010, the data set was filled by collecting statistics on the medical doctors trained in Romania and practicing abroad from the destination countries. The results confirm the concern rose about the massive emigration of medical doctors following the integration, compared to the previous period: between 2007 and 2010, Romania lost 8131 physicians. This study has major implications for academics with interest in modeling the effects of medical brain drain on economic development. Also it is a valuable instrument for policy makers, offering an overview of the magnitude of this phenomenon, helpful in adopting the right policy measures. The article offers a unique data set on the emigration of physicians, constituting a starting point in the attempt of implementing a monitoring system.

  11. Ultrastructure of the seminiferous tubules in human testes before and after varicocelectomy.

    Science.gov (United States)

    Ozgür, H; Kaya, M; Doran, S; Solmaz, S

    2003-12-01

    Ultrastructure of the membrana propria and the seminiferous epithelium was studied in infertile human testis both before and 3-6 months after varicocelectomy. The frequent alterations, observed before and after the operation, were extremely thickened membrana propria, deep invaginations, multilamination and knob-like formation of basal laminae and formation of multinucleated spermatids, which were all considered as the common response of the testis to different noxious agents. Although the cells of the seminiferous epithelium were clearly affected by varicocele before varicocelectomy, many areas exhibited normal features after the operation. Furthermore, multinucleated cells, sharing common features of Sertoli cell and spermatogonium, were observed, as well as presence of well-developed annulate lamellae in the Sertoli cells, exhibiting centrioles in the vicinity of their nuclei after varicocelectomy. These multiple ultrastructural observations indicate that Sertoli cell division takes place. This study suggests that if the observation period of the tissue samples after varicocelectomy is long enough, the reversible changes of the tubular cells would be seen much more frequently. PMID:14618398

  12. Enterovirus survey before and after poliomyelitis vaccination in Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Tan, D S; Lam, S K

    1978-09-01

    Stool samples from healthy children mainly of the low income group aged 0 to 7 years of age from five Maternal and Child Health Centres in Kuala Lumpur were obtained for isolation of enteroviruses. The specimens were collected before and after the mass vaccination given in the face of polio type 1 epidemic which started in October, 1971. The prevelance rate of enteroviruses was 11.9% (3.0% polioviruses, 8.9% non-polio enteroviruses) before the vaccination and essentially the same after. Coxsackie A viruses predominated over the other enteroviruses in the pre- and post-vaccination phases. The highest isolation rate of enteroviruses was observed in children 0 to 2 years age. No significant differences in distribution by sex, race and month were noted. A sharp fall in the prevalence rates of total enteroviruses and polioviruses was noted shortly after the mass vaccination campaign However, the rates reverted to the pre-vaccination state during the next successive years.

  13. Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

    Science.gov (United States)

    Slawik, Helen; Stoffel, Michael; Riedl, Lina; Veselý, Zdenko; Behr, Michael; Lehmberg, Jens; Pohl, Corina; Meyer, Bernhard; Wiegand, Michael; Krieg, Sandro M

    2016-02-01

    Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral oscillators. Although exogenous melatonin is approved for circadian rhythm sleep disorders and old-age insomnia, research on endogenous melatonin in humans is hindered by the great interindividual variability of its amount and circadian rhythm. Single case studies on pinealectomized patients report on disrupted but also hypersomnic sleep. This is the first systematic prospective report on sleep with respect to pinealectomy due to pinealocytoma World Health Organization grade I without chemo- or radiotherapy. Before and after pinealectomy, 8 patients completed questionnaires on sleep quality and circadian rhythm (Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Morningness-Eveningness Questionnaire), 2 nights of polysomnography, salivary evening melatonin profiles, and qualitative assessment of 2 weeks of actigraphy and sleep logs. Six patients were assessed retrospectively up to 4 years after pinealectomy. Before pinealectomy, all but 1 patient showed an evening melatonin rise typical for indifferent chronotypes. After pinealectomy, evening saliva melatonin was markedly diminished, mostly below the detection limit of the assay (0.09 pg/mL). No systematic change in subjective sleep quality or standard measures of polysomnography was found. Mean pre- and postoperative sleep efficiency was 94% and 95%, and mean sleep-onset latency was 21 and 17 min, respectively. Sleep-wake rhythm during normal daily life did not change. Retrospective patients had a reduced sleep efficiency (90%) and more stage changes, although this was not significantly different from prospective patients. In conclusion, melatonin does seem to have a modulatory, not a

  14. Sexual behaviour reported by a sample of Italian MSM before and after HIV diagnosis

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    Laura Camoni

    2011-01-01

    Full Text Available In 2006 we conducted a cross-sectional study involving hospital clinical centres in five Italian cities to compare the sexual behaviour of HIV-positive MSM (men who have sex with men before and after the diagnosis of HIV infection. Each centre was asked to enrol 30 HIV-positive persons aged > 18 years. The questionnaire was administered to 143 MSM on average 9 years after HIV diagnosis. After diagnosis there was a decrease in the number of sexual partners: the percentage of persons who reported having had more than 2 partners decreased from 95.8% before diagnosis to 76.2% after diagnosis. After diagnosis, there was a significant decrease in the percentage of persons who had never (or not always used a condom with their stable partner for anal sex from 69.2% before diagnosis to 26.6% after diagnosis and for oral-genital sex from 74.8% before diagnosis to 51.7% after diagnosis. Though at-risk behaviour seems to decrease after diagnosis, seropositive MSM continue to engage in at-risk practices: one fourth of them did not use a condom during sexually transmitted infections (STI episodes, 12.5% of the participants had had sex for money, and 8.4% had paid for sex. The study shows that our sample of Italian HIV-positive MSM, though aware of being infected, engage in sexual behaviours that could sustain transmission of HIV and other STIs. The results could constitute the first step in implementing national prevention programs for persons living with HIV.

  15. Disparities in colorectal cancer in African-Americans vs Whites: Before and after diagnosis

    Institute of Scientific and Technical Information of China (English)

    Anastasios Dimou; Kostas N Syrigos; Muhammad Wasif Saif

    2009-01-01

    There are differences between African-American and white patients with colorectal cancer, concerning their characteristics before and after diagnosis. Whites are more likely to adhere to screening guidelines. This is also the case among people with positive family history. Colorectal cancer is more frequent in Blacks. Studies have shown that that since 1985, colon cancer rates have dipped 20% to 25% for Whites, while rates have gone up for African-American men and stayed the same for African-American women. Overall, African-Americans are 38% to 43% more likely to die from colon cancer than are Whites. Furthermore, it seems that there is an African-American predominance in right-sited tumors. African Americans tend to be diagnosed at a later stage, to suffer from better differentiated tumors, and to have worse prognosis when compared with Whites. Moreover, less black patients receive adjuvant chemotherapy for resectable colorectal cancer or radiation therapy for rectal cancer. Caucasians seem to respond better to standard chemotherapy regimens than African- Americans. Concerning toxicity, it appears that patients of African-American descent are more likely to develop 5-FU toxicity than Whites, possibly because of their different dihydropyridine dehydrogenase status. Last but not least, screening surveillance seems to be higher among white than among black long-term colorectal cancer survivors. Socioeconomic and educational status account for most of these differences whereas little evidence exists for a genetic contribution in racial disparity. Understanding the nature of racial differences in colorectal cancer allows tailoring of screening and treatment interventions.

  16. Comet 17P/Holmes: contrast in activity between before and after the 2007 outburst

    Energy Technology Data Exchange (ETDEWEB)

    Ishiguro, Masateru; Kim, Yoonyoung; Warjurkar, Dhanraj S.; Ham, Ji-Beom [Department of Physics and Astronomy, Seoul National University, Gwanak, Seoul 151-742 (Korea, Republic of); Kim, Junhan [Department of Astronomy and Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Usui, Fumihiko [Department of Astronomy, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Vaubaillon, Jeremie J. [Observatoire de Paris, I.M.C.C.E., Denfert Rochereau, Bat. A., F-75014 Paris (France); Ishihara, Daisuke [Department of Physics, School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8602 (Japan); Hanayama, Hidekazu [Ishigakijima Astronomical Observatory, National Astronomical Observatory of Japan, Ishigaki, Okinawa 907-0024 (Japan); Sarugaku, Yuki; Hasegawa, Sunao [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Kasuga, Toshihiro; Watanabe, Jun-ichi [National Astronomical Observatory, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Pyo, Jeonghyun [Korea Astronomy and Space Science Institute, Daejeon 305-348 (Korea, Republic of); Kuroda, Daisuke [National Institutes of Natural Sciences, Okayama Astrophysical Observatory, Kamogata-cho, Okayama 719-0232 (Japan); Ootsubo, Takafumi [Astronomical Institute, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Sakamoto, Makoto; Narusawa, Shin-ya; Takahashi, Jun [Nishi-Harima Astronomical Observatory, Center for Astronomy, University of Hyogo, Sayo, Hyogo 679-5313 (Japan); Akisawa, Hiroki, E-mail: ishiguro@astro.snu.ac.kr [Himeji City Science Museum, Himeji, Hyogo 671-2222 (Japan)

    2013-11-20

    A Jupiter-family comet, 17P/Holmes, underwent outbursts in 1892 and 2007. In particular, the 2007 outburst is known as the greatest outburst over the past century. However, little is known about the activity before the outburst because it was unpredicted. In addition, the time evolution of the nuclear physical status has not been systematically studied. Here, we study the activity of 17P/Holmes before and after the 2007 outburst through optical and mid-infrared observations. We found that the nucleus was highly depleted in its near-surface icy component before the outburst but that it became activated after the 2007 outburst. Assuming a conventional 1 μm sized grain model, we derived a surface fractional active area of 0.58% ± 0.14% before the outburst whereas the area was enlarged by a factor of ∼50 after the 2007 outburst. We also found that large (≥1 mm) particles could be dominant in the dust tail observed around aphelion. Based on the size of the particles, the dust production rate was ≳170 kg s{sup –1} at a heliocentric distance of r{sub h} = 4.1 AU, suggesting that the nucleus was still active around the aphelion passage. The nucleus color was similar to that of the dust particles and average for a Jupiter-family comet but different from that of most Kuiper Belt objects, implying that color may be inherent to icy bodies in the solar system. On the basis of these results, we concluded that more than 76 m of surface material was blown off by the 2007 outburst.

  17. Self-Reported Cognitive Outcomes in Patients With Brain Metastases Before and After Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Ansa Maer [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Scherwath, Angela [Department of Medical Psychology, University Medical Centre Hamburg-Eppendorf, Hamburg (Germany); Ernst, Gundula [Department of Medical Psychology, Medical School Hannover, Hannover (Germany); Lanfermann, Heinrich [Institute for Neuroradiology, Medical School Hannover, Hannover (Germany); Bremer, Michael [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Steinmann, Diana, E-mail: steinmann.diana@mh-hannover.de [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany)

    2013-11-15

    Purpose: Patients with brain metastases may experience treatment-related cognitive deficits. In this study, we prospectively assessed the self-reported cognitive abilities of patients with brain metastases from any solid primary cancer before and after irradiation of the brain. Methods and Materials: The treatment group (TG) consisted of adult patients (n=50) with brain metastases who received whole or partial irradiation of the brain without having received prior radiation therapy (RT). The control group (CG) consisted of breast cancer patients (n=27) without cranial involvement who were treated with adjuvant RT. Patients were recruited between May 2008 and December 2010. Self-reported cognitive abilities were acquired before RT and 6 weeks, 3 months, and 6 months after irradiation. The information regarding the neurocognitive status was collected by use of the German questionnaires for self-perceived deficits in attention (FEDA) and subjectively experienced everyday memory performance (FEAG). Results: The baseline data showed a high proportion of self-perceived neurocognitive deficits in both groups. A comparison between the TG and the CG regarding the course of self-reported outcomes after RT showed significant between-group differences for the FEDA scales 2 and 3: fatigue and retardation of daily living activities (P=.002) and decrease in motivation (P=.032) with an increase of attention deficits in the TG, but not in the CG. There was a trend towards significance in FEDA scale 1: distractibility and retardation of mental processes (P=.059) between the TG and the CG. The FEAG assessment presented no significant differences. An additional subgroup analysis within the TG was carried out. FEDA scale 3 showed significant differences in the time-related progress between patients with whole-brain RT and those receiving hypofractionated stereotactic RT (P=.025), with less decrease in motivation in the latter group. Conclusion: Self-reported attention declined in

  18. Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.

    Directory of Open Access Journals (Sweden)

    Pascale M Y Smets

    Full Text Available Objectives of this study were to evaluate glomerular filtration rate (GFR, renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6 or placebo (control group, n = 5. Urinary markers, GFR and kidney biopsies were evaluated before (T0, during (T16 wks and after discontinuing HC administration (T24 wks. Results indicate that HC administration causes a significant increase in GFR. At all time points except T16 wks, proteinuria was higher in the control group than in the HC group, and there was no significant difference in urinary markers between groups. At T16 wks, proteinuria, urinary albumin-to-creatinine (c ratio, immunoglobulin G/c and retinol-binding protein/c were higher compared to baseline in the HC group. At T0, rare to mild renal lesions were detected in all HC dogs and rare to moderate changes in all control dogs. Glomerulosclerosis progressed in both groups until T24 wks. Tubular atrophy was detected in three HC dogs at T16 wks and T24 wks, but also in five control dogs throughout the study. At every time point, five HC dogs and all control dogs had rare to moderate interstitial inflammation. Rare to mild interstitial fibrosis was found in up to three HC dogs at T16 wks and T24 wks, and severe fibrosis in one HC dog at T24 wks. Up to four control dogs had rare to mild fibrosis at all time points. These findings indicate that clinically healthy, aged Beagle dogs may have considerable renal lesions and proteinuria, which could have implications for experimental or toxicological studies. Additional research is needed to elucidate glucocorticoid effects on renal structure, but functional changes such as hyperfiltration and proteinuria warrant attention to kidney function of canine patients with Cushing's syndrome or receiving exogenous glucocorticoids.

  19. Gene expression during Drosophila melanogaster egg development before and after reproductive diapause

    Directory of Open Access Journals (Sweden)

    Baker Dean A

    2009-05-01

    Full Text Available Abstract Background Despite the importance of egg development to the female life cycle in Drosophila, global patterns of gene expression have not been examined in detail, primarily due to the difficulty in isolating synchronised developmental stages in sufficient quantities for gene expression profiling. Entry into vitellogenesis is a key stage of oogenesis and by forcing females into reproductive diapause we are able to arrest oogenesis at the pre-vitellogenic stages. Releasing females from diapause allows collection of relatively synchronous developing egg populations and an investigation of some of the transcriptional dynamics apparent before and after reproductive diapause. Results Focusing on gender-biased transcription, we identified mechanisms of egg development suppressed during reproductive dormancy as well as other molecular changes unique to the diapausing female. A microarray based analysis generated a set of 3565 transcripts with at least 2-fold greater expression in females as compared to control males, 1392 such changes were biased during reproductive dormancy. In addition, we also detect 1922 up-regulated transcriptional changes after entry into vitellogenesis, which were classified into discrete blocks of co-expression. We discuss some of the regulatory aspects apparent after re-initiation of egg development, exploring the underlying functions, maternal contribution and evolutionary conservation of co-expression patterns involved in egg production. Conclusion Although much of the work we present is descriptive, fundamental aspects of egg development and gender-biased transcription can be derived from our time-series experiment. We believe that our dataset will facilitate further exploration of the developmental and evolutionary characteristics of oogenesis as well as the nature of reproductive arrest in Drosophila.

  20. Characterization of Brazilian mango kernel fat before and after gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, Fabiana da Silva; Ramos, Clecio Souza, E-mail: fasiaquino@yahoo.com.br, E-mail: clecio@dcm.ufrpe.br [Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE (Brazil); Aquino, Katia Aparecida da Silva, E-mail: aquino@ufpe.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

    2013-07-01

    Mangifera indica Linn (family of Anacardiaceae) is a tree indigenous to India, whose both unripe and ripe fruits (mangoes) are widely used by the local population. After consumption or industrial processing of the fruits, considerable amounts of mango seeds are discarded as waste. The kernel inside the seed represents from 45% to 75% of the seed and about 20% of the whole fruit and lipid composition of mango seed kernels has attracted the attention of researches because of their unique physical and chemical characteristics. Our study showed that fat of the mango kernel obtained by Soxhlet extraction with hexane had a solid consistency at environmental temperature (27 deg C) because it is rich in saturated acid. The fat contents of the seed of Mangifera indica was calculated to 10% and are comparable to the ones for commercial vegetable oils like soybean (11-25%). One problem found in the storage of fast and oils is the attack by microorganisms and the sterilization process becomes necessary. Samples of kernel fat were irradiated with gamma radiation ({sup 60}Co) at room temperature and air atmosphere at 5 and 10 kGy (sterilization doses). The data of GC-MS analysis revealed the presence of four major fatty acids in the sample of mango kernel examined and that the chemical profile of the sample not altered after being irradiated. Moreover, analysis of Proton Nuclear Magnetic Resonance (NMR H{sup 1}) was used to obtain the mango kernel fat parameters before and after gamma irradiation. The data interpretation of RMN H{sup 1} indicated that there are significant differences in the acidity and saponification indexes of fat. However, it was found an increase of 14% in iodine index of fat after irradiation. This result means that some double bonds were formed on the irradiation process of the fat. (author)

  1. Self-Reported Cognitive Outcomes in Patients With Brain Metastases Before and After Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: Patients with brain metastases may experience treatment-related cognitive deficits. In this study, we prospectively assessed the self-reported cognitive abilities of patients with brain metastases from any solid primary cancer before and after irradiation of the brain. Methods and Materials: The treatment group (TG) consisted of adult patients (n=50) with brain metastases who received whole or partial irradiation of the brain without having received prior radiation therapy (RT). The control group (CG) consisted of breast cancer patients (n=27) without cranial involvement who were treated with adjuvant RT. Patients were recruited between May 2008 and December 2010. Self-reported cognitive abilities were acquired before RT and 6 weeks, 3 months, and 6 months after irradiation. The information regarding the neurocognitive status was collected by use of the German questionnaires for self-perceived deficits in attention (FEDA) and subjectively experienced everyday memory performance (FEAG). Results: The baseline data showed a high proportion of self-perceived neurocognitive deficits in both groups. A comparison between the TG and the CG regarding the course of self-reported outcomes after RT showed significant between-group differences for the FEDA scales 2 and 3: fatigue and retardation of daily living activities (P=.002) and decrease in motivation (P=.032) with an increase of attention deficits in the TG, but not in the CG. There was a trend towards significance in FEDA scale 1: distractibility and retardation of mental processes (P=.059) between the TG and the CG. The FEAG assessment presented no significant differences. An additional subgroup analysis within the TG was carried out. FEDA scale 3 showed significant differences in the time-related progress between patients with whole-brain RT and those receiving hypofractionated stereotactic RT (P=.025), with less decrease in motivation in the latter group. Conclusion: Self-reported attention declined in

  2. Radiation incidents involving human exposure in the former USSR before and after Chernobyl

    International Nuclear Information System (INIS)

    The Chernobyl accident has changed the people representations on the degree of danger for the person of development of a nuclear power. From more than 384 people involved, from 134 suffered from acute radiation syndrome, from which 28 persons died at the acute period. And what has been happening before and after Chernobyl? Which radiating incidents took place on a territory of former USSR and on which ''background'' Chernobyl consequences are observed? Materials of the Registry of SRSR - Institute of Biophysics (IBP), which clinical department has provided medical assistance, observation and treatment in the majority of victims damaged at radiating incidents on a territory of former USSR, certifies that at least 147 radiating incidents have taken place for a period from 1950 to 1996 (excluding South Urals accidents, nuclear submarine accidents and consequences of nuclear explosions). More than 776 individuals were exposed in these incidents. It is authentically known, that at least 393 of them were observed with clinical symptoms of acute radiation injury, local radiation damages or their combinations, and 57 patients died during acute period of radiation injury and about half of given statistics are on the Chernobyl accident. More than half the cases (79 of 147) were connected to radioisotope devices and their sources of radiations. In the last three decades small fluctuations of frequency of radiating incidents, on the average are observed: about 3-4 cases in a year (maximum 9, 1971) from which, only 1-2 with two and more damaged and about one case in two years with fatal outcomes at the acute period. Quantity of victims with clinical symptoms makes on the average 5-6 in a year, and with fatal outcome - on the average less than one case in a year before Chernobyl accident and only three cases for 10-year period after Chernobyl

  3. Characterization of Brazilian mango kernel fat before and after gamma irradiation

    International Nuclear Information System (INIS)

    Mangifera indica Linn (family of Anacardiaceae) is a tree indigenous to India, whose both unripe and ripe fruits (mangoes) are widely used by the local population. After consumption or industrial processing of the fruits, considerable amounts of mango seeds are discarded as waste. The kernel inside the seed represents from 45% to 75% of the seed and about 20% of the whole fruit and lipid composition of mango seed kernels has attracted the attention of researches because of their unique physical and chemical characteristics. Our study showed that fat of the mango kernel obtained by Soxhlet extraction with hexane had a solid consistency at environmental temperature (27 deg C) because it is rich in saturated acid. The fat contents of the seed of Mangifera indica was calculated to 10% and are comparable to the ones for commercial vegetable oils like soybean (11-25%). One problem found in the storage of fast and oils is the attack by microorganisms and the sterilization process becomes necessary. Samples of kernel fat were irradiated with gamma radiation (60Co) at room temperature and air atmosphere at 5 and 10 kGy (sterilization doses). The data of GC-MS analysis revealed the presence of four major fatty acids in the sample of mango kernel examined and that the chemical profile of the sample not altered after being irradiated. Moreover, analysis of Proton Nuclear Magnetic Resonance (NMR H1) was used to obtain the mango kernel fat parameters before and after gamma irradiation. The data interpretation of RMN H1 indicated that there are significant differences in the acidity and saponification indexes of fat. However, it was found an increase of 14% in iodine index of fat after irradiation. This result means that some double bonds were formed on the irradiation process of the fat. (author)

  4. Free living energy expenditure in post menopausal women before and after exercise training.

    Science.gov (United States)

    Keytel, L R; Lambert, M I; Johnson, J; Noakes, T D; Lambert, E V

    2001-06-01

    The aim of the study was to determine the effects of 8 weeks of moderate exercise training, on 24-hour free living energy expenditure in previously sedentary post-menopausal women. The experimental group (EX) included 9 women. Ten non-exercising control subjects (CON) were recruited to undergo pre- and post-testing. Estimated total daily energy expenditure (TDEE), total 24-hour heart beats (HB), total energy intake (TEI), resting metabolic rate, maximal oxygen consumption (VáO2max), body composition, and submaximal heart rate were measured before and after the exercise intervention. Body composition did not change (body fat % in CON 34.0 +/- 4.0% vs. 33.9 +/- 3.6% and EX 34.1 +/- 4.0% vs. 34.0 +/- 3.4%). Mean submaximal heart rate during steady-state exercise in EX was lower after training compared to CON (p post, respectively), RMR (CON 134.2 +/- 9.4 vs. 136.9 +/- 15.0 KJ/kgFFM/day, and EX 138.4 +/- 6.4 vs. 140.7 +/- 14.2 KJ/kgFFM/day, pre vs. post, respectively), TEI (CON 7.9 +/- 2.2 vs. 8.2 +/- 2.5 MJ, and EX 9.4 +/-1.6 vs. 8.3 +/- 2.8 MJ), nor HB (CON 110,808 +/- 12,574 vs. 107,366 +/- 12,864 beats, and EX 110,188 +/- 9,219 vs. 114,590 +/- 12,750 beats) change over 8 weeks in either group. These data suggest that a moderate exercise program may not impact on TDEE, RMR, TEI, or HB in previously sedentary, older women.

  5. Mutans streptococci strains prevalence before and after cavity preparation during Atraumatic Restorative Treatment.

    Science.gov (United States)

    Toi, C S; Bönecker, M; Cleaton-Jones, P E

    2003-06-01

    Critics argue that all carious dentine is not removed from the hand-prepared cavity during the Atraumatic Restorative Treatment (ART) procedure, and that the caries process is soon resumed. The aim of this study was to determine the effectiveness of ART in removing carious tissue, by investigating the numbers of mutans streptococci and lactobacilli, with emphasis on the prevalence of Streptococcus mutans and Streptococcus sobrinus strains before, and after ART treatment of dental caries. Two microbiology samples were collected. The first sample was removed from the centre of the carious lesion at the enamel-dentine junction, and the second was collected from the centre of the hard cavity wall above the pulp, after the soft infected dentine had been manually removed. A total of 71 mutans streptococci isolates from 31 children and 40 carious teeth were subcultured, biochemically characterised and genotyped by the arbitrarily primed polymerase chain reaction (AP-PCR). Results showed a significant decrease in TVC (Ppreparation. AP-PCR identified S. mutans strains that were undetectable during biotyping, and divided clinical isolates into two main clusters. In all, 63% (45/71) of isolates from the carious lesions comprised S. mutans strains. After cavity preparation, this was reduced to 35% (25/71), of which 30% (21/71) were S. mutans and the remaining 6% (4/71) S. sobrinus strains. The number of mutans streptococci strains was below detectable levels in 19 of the prepared cavities. The significant decrease in bacteria after manual cavity preparation demonstrates the reliability of a standardized ART technique, yet the presence of S. mutans strains shows that the effectiveness of the ART procedure can vary during treatment and between dental practitioners.

  6. Environmental organic pollutants in human milk before and after weight loss.

    Science.gov (United States)

    Lignell, Sanna; Winkvist, Anna; Bertz, Fredrik; Rasmussen, Kathleen M; Glynn, Anders; Aune, Marie; Brekke, Hilde Kristin

    2016-09-01

    Many persistent organic pollutants (POPs) are banned because they accumulate in organisms and are toxic. Lipophilic POPs are stored in maternal adipose tissue and concentrations in human milk (HM) may increase during weight loss. Our aim was to examine associations between weight loss and concentrations of chlorinated POPs in HM in lactating women participating in a weight loss study. We analysed POPs (PCB 28, PCB 153, HCB, DDE) in HM at 12 and 24 weeks postpartum from 32 women who participated in a randomized, 2 × 2 factorial trial of diet and exercise for postpartum weight loss. Participants donated milk before and after the intervention period. We examined associations between weight loss and change in POP concentrations and estimated the intake of POPs by their breastfed infants. Most (n = 27) women lost weight during intervention, 0.45 ± 0.30 kg/week (mean ± SD). Among these women, the concentration of PCB 153 in HM was significantly (p = 0.04) higher at follow-up than at baseline. Weight loss was significantly positively associated with changes in concentrations of all studied POPs (2.0-2.4% increase per percent weight loss). Estimated mean intakes of POPs (ng/day) remained stable because infant milk consumption decreased during the study period. As infants gained weight, estimated mean intakes per kg body weight decreased 17-22%. Changes in concentrations of POPs in HM correlated positively with maternal weight loss, but it is unlikely that the balance between the benefits and risks of breastfeeding will change if the weight loss is restricted to 0.5 kg per week. PMID:27281542

  7. The cost of hospital care in the year before and after parasuicide.

    Science.gov (United States)

    O'Sullivan, M; Lawlor, M; Corcoran, P; Kelleher, M J

    1999-01-01

    This study, based in Ireland in the Limerick centre of the WHO/EURO Multicentre Study of Parasuicide, tests the hypothesis that the uptake of hospital services increases significantly following an act of parasuicide. To investigate this, the costs of hospital attendance in the year before and in the year after an act of parasuicide are measured and compared. The sample is comprised of the first 100 individuals who attended an acute general hospital following an act of parasuicide after July 1, 1995. Using a computerized patient record system, every hospital attendance is identified, for each individual, in the 12 months before and after the parasuicide act. This includes every visit to the Emergency Room as well as both general and psychiatric inpatient admissions and outpatient attendances. There was a 50% increase in the uptake of hospital services--32% of the sample attended hospital in the year before compared with 48% in the year after. The total yearly costs for the 100 patients almost doubled from IR 53,652 Pounds (Euro 68,138) to IR 104,454 Pounds (Euro 132,657). Generalizing to the 539 individuals who engaged in parasuicide in the Limerick catchment area, total costs increased from IR 289,184 Pounds (Euro 367,264) to IR 563,007 Pounds (Euro 715,019). This study is an initial step toward the more complex task of estimating to what extent the increased uptake of hospital services is due to the consequences of parasuicide and how much is due to other aspects of the patient's health. PMID:10680285

  8. Plasticity of visual attention in Isha yoga meditation practitioners before and after a 3-month retreat

    Directory of Open Access Journals (Sweden)

    Claire eBraboszcz

    2013-12-01

    Full Text Available Meditation has lately received considerable interest from cognitive neuroscience. Studies suggest that daily meditation leads to long lasting attentional and neuronal plasticity. We present changes related to the attentional systems before and after a 3 month intensive meditation retreat. We used 3 behavioral psychophysical tests - a Stroop task, an attentional blink task, and a global-local letter task - to assess the effect of Isha yoga meditation on attentional resource allocation. 82 Isha yoga practitioners were tested at the beginning and at the end of the retreat. Our results showed an increase in correct responses specific to incongruent stimuli in the Stroop task. Congruently, a positive correlation between previous meditation experience and accuracy to incongruent Stroop stimuli was also observed at baseline. We also observed a reduction of the attentional blink. Unexpectedly, a negative correlation between previous meditation experience and attentional blink performance at baseline was observed. Regarding spatial attention orientation as assessed using the global-local letter task, participants showed a bias toward local processing. Only slight differences in performance were found pre- vs. post- meditation retreat. Previous meditation experience influenced the Stroop and attentional blink tasks in opposite directions – for the Stroop task congruent with the improvements seen after the retreat whereas for the attentional blink previous experience correlated negatively with performance. Biasing towards the local stimuli in the global-local task and negative correlation of previous meditation experience with attentional blink performance is consistent with Isha practices being more focused-attention practices. Given the relatively small effect sizes and the absence of a control group, our results do not allow clear support nor rejection of the hypothesis of meditation-driven neuronal plasticity in the attentional system for Isha yoga

  9. Microscopic Structures of Endosperms Before and After Gelatinization in Rice Varieties with Varied Grain Quality

    Institute of Scientific and Technical Information of China (English)

    YANG Ze-min; WANG Wei-jin; LAN Sheng-yin; XU Zhen-xiu; ZHOU Zhu-qing; WANG Meng

    2003-01-01

    The microscopic structures of the endosperm of indica rice varieties with different quality be-fore and after gelatinization were observed using scanning electron microscope. The results showed that the de-gree of gelatinization varied in different parts of the grain and in different varieties under the same experimen-tal conditions. The gelatinization of dorsal side was the most complete. Its cells were decomposed totally intopuff-like or flocculent materials. The ventral side gelatinized less thoroughly, appearing agglomerate and somecell frames were still visible. The middle part gelatinized most incompletely and the cells were still integrated.Evident differences in gelatinization were observed among different varieties, the dorsal, ventral and middleparts of high quality varieties gelatinized more thoroughly than those of the corresponding parts of low qualityvarieties respectively. An obvious concavity often appeared in the middle of the cross-section of the low qualitygrains while the cross-section of high quality grains was normally flat. The same phenomenon was noted whencomparing the early maturing indica rice and the late maturing indica rice. Varietal difference of gelatiniza-tion in dorsal sides was not as distinct as in middle parts and ventral sides. The difference among dorsal side,middle part and ventral side in gelatinization was greater in low quality grains than that of high quality grains.In addition, a lot of ruptured cells were observed in the cross-section of high quality rice, while few of themcould be found in the low quality rice. Apparently, the number of ruptured cells is positively correlated withrice quality. Quality of rice grain also has positive correlation with the rate of water absorption and extension. Highrates of water absorption and extension lead to better gelatinization of rice grain, and hence indicate good quality.

  10. Changes in angiotensin II receptor bindings in the hen neurohypophysis before and after oviposition.

    Science.gov (United States)

    Takahashi, T; Nozaki, Y; Nakagawa-Mizuyachi, K; Nakayama, H; Kawashima, M

    2011-11-01

    The present study was performed to elucidate whether the angiotensin II (ANG II) receptor exists in the plasma membrane fraction of the neurohypophysis in hens, to estimate the time of action of ANG II on the neurohypophysis before and after oviposition, and to examine relationships between the action of ANG II on the neurohypophysis and those of estrogen and prostaglandin F(2α) (PGF(2α)) in relation to arginine vasotocin (AVT) release. The specific binding had a binding specificity to chicken ANG II (cANG II), reversibility, and saturation in the [(125)I]cANG II binding assay. Scatchard analysis revealed that the binding sites are of a single class. The equilibrium dissociation constant (K(d)) obtained by kinetic analysis and Scatchard analysis suggested a high affinity, and the maximum binding capacity (B(max)) obtained by Scatchard analysis suggested a limited capacity. These results suggest that an ANG II receptor exists in the neurohypophysis of hens. The K(d) and the B(max) value was significantly smaller in laying hens than in nonlaying hens, which suggests that bindings of the cANG II receptor change, depending on the difference in laying condition. Values of the K(d) and the B(max) decreased approximately 15 min before oviposition in laying hens, and decreased 1 h after an intramuscular injection of estradiol-17β and 5 min after an intravenous injection of cANG II in nonlaying hens. The amount of specific binding of PGF(2α) receptor in the neurohypophysis also decreased and AVT concentration in blood increased after the cANG II injection. It seems likely that the action of cANG II in the neurohypophysis increases due to the effect of estrogen approximately 15 min before oviposition, and the cANG II action stimulates AVT release through the increase in the PGF(2α) action in this tissue. PMID:22010242

  11. Bioimpedance spectroscopy for assessment of volume status in patients before and after general anaesthesia.

    Directory of Open Access Journals (Sweden)

    Matthäus Ernstbrunner

    Full Text Available BACKGROUND: Technically assisted assessment of volume status before surgery may be useful to direct intraoperative fluid administration. We therefore tested a recently developed whole-body bioimpedance spectroscopy device to determine pre- to postoperative fluid distribution. METHODS: Using a three-compartment physiologic tissue model, the body composition monitor (BCM, Fresenius Medical Care, Germany measures total body fluid volume, extracellular volume, intracellular volume and fluid overload as surplus or deficit of 'normal' extracellular volume. BCM-measurements were performed before and after standardized general anaesthesia for gynaecological procedures (laparotomies, laparoscopies and vaginal surgeries. BCM results were blinded to the attending anaesthesiologist and data analysed using the 2-sided, paired Student's t-test and multiple linear regression. RESULTS: In 71 females aged 45 ± 15 years with body weight 67 ± 13 kg and Duration of anesthesia 154 ± 69 minutes [corrected] duration of anaesthesia 154 ± 68 min, pre- to postoperative fluid overload increased from -0.7 ± 1.1 L to 0.1 ± 1.0 L, corresponding to -5.1 ± 7.5% and 0.8 ± 6.7% of normal extracellular volume, respectively (both p<0.001, after patients had received 1.9 ± 0.9 L intravenous crystalloid fluid. Perioperative urinary excretion was 0.3 ± 0.2 L [corrected]. The increase in extracellular volume was paralleled by an increase in total body fluid volume, while intracellular volume increased only slightly and without reaching statistical significance (p = 0.15. Net perioperative fluid balance (administered fluid volume minus urinary excretion was significantly associated with change in extracellular volume (r(2 = 0.65, but was not associated with change in intracellular volume (r(2 = 0.01. CONCLUSIONS: Routine intraoperative fluid administration results in a significant, and clinically meaningful increase in the extracellular compartment. BCM-measurements yielded

  12. Immunocytochemical studies of chicken somatotrophs and somatotroph granules before and after hatching.

    Science.gov (United States)

    Malamed, S; Gibney, J A; Cain, L D; Perez, F M; Scanes, C G

    1993-05-01

    Immunocytochemical methods were used to gain information about the embryonic development of chicken somatotrophs before and after hatching. To localize growth hormone, anterior pituitary sections were incubated with growth-hormone antibody, and then an indirect peroxidase method was used for light microscopy and an immunogold method for electron microscopy. The earliest evidence of embryonic somatotrophs was seen at 12 days. At this stage somatotrophs were sparse (0.2% of parenchymal cells) and their granules were pleomorphic with elongated ovoid and lozenge shapes predominating. Few of the immunogold-labeled somatotroph granules of the embryo were spherical until 15 days after fertilization. At 18 days, most of the granules were spherical (their shape in the adult chicken). During the six days between the 15-day-old embryo and the 1-day-old chick, the number of gold particles per granule section approximately doubled suggesting an increase in growth hormone content of the granules. This rise was the result of increases in the size of the granule sections and in the concentration of gold particles in the sections. During the embryonic period of 12-20 days, somatotrophs were not more than 3.6% of the anterior pituitary cell population. During the following two days, between the 20-day-old embryo and the 1-day-old chick, the percentage of somatotrophs in the pituitary parenchymal cell population rose rapidly from 3.6% to 20.7% and then increased slowly to 24.6% during the period of 1-5 days after hatching.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

    Science.gov (United States)

    Chowdhury, Abeed H; Camara, Miguel; Martinez-Pomares, Luisa; Zaitoun, Abed M; Eremin, Oleg; Aithal, Guruprasad P; Lobo, Dileep N

    2016-09-01

    This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and their expression of co-stimulatory molecules were also studied. Forty patients with OJ and ten non-jaundiced patients with normal gastroscopy findings were recruited. Ten healthy volunteers provided control blood samples for immunological assays. Patients with OJ had blood and duodenal mucosa sampled at the time of endoscopic retrograde cholangiopancreatography (ERCP) and further blood sampled during the recovery phase. Monocyte cytokine responses to LPS, DC subsets and co-stimulatory molecule expression were compared with controls. Duodenal morphology and occludin expression were also assessed. Monocytes obtained before ERCP from jaundiced patients demonstrated reduced cytokine responses to endotoxin compared with controls (IL-1β: 2678 compared with 4631 pg/ml, P=0.04 and IL-6: 3442 compared with 6157 pg/ml, P=0.002). Monocytes from patients with malignancy had poorer responses to endotoxin than from those with benign OJ (IL-1β: 2025 compared with 3332 pg/ml, P=0.001). After ERCP, the secretion of inflammatory cytokines by monocytes obtained from jaundiced patients increased (IL-1β: 2150 compared with 2520 pg/ml, P=0.03 and IL-6: 2488 compared with 3250 pg/ml, P=0.01). Occludin expression (85 compared with 95%, P=0.004) and mean duodenal villus height (334 compared with 404 μm, P=0.03) were lower in jaundiced patients. Before biliary drainage, patients with OJ had a higher percentage of myeloid dendritic cells (mDCs) and greater mDC expression of CD40 (P=0.04) and CD86 (P=0.04). Monocytes from patients with OJ had lower proinflammatory cytokine secretion in response to LPS, an effect reversed following biliary drainage. PMID:27252406

  14. Changes in quality of life and perceptions of general health before and after operation of wind turbines.

    Science.gov (United States)

    Jalali, Leila; Bigelow, Philip; McColl, Stephen; Majowicz, Shannon; Gohari, Mahmood; Waterhouse, Ryan

    2016-09-01

    Ontario is Canada's provincial leader in wind energy, with over 4000 MW of installed capacity supplying approximately five percent of the province's electricity demand. Wind energy is now one of the fastest-growing sources of renewable power in Canada and many other countries. However, its possible negative impact on population health, as a new source of environmental noise, has raised concerns for people living in proximity to wind turbines (WTs). The aims of this study were to assess the effect of individual differences and annoyance on the self-reported general health and health-related quality of life (QOL) of nearby residents, using a pre- and post-exposure design. Prospective cohort data were collected before and after WT operations, from the individuals (n = 43) in Ontario, Canada. General health and QOL metrics were measured using standard scales, such as SF12, life satisfaction scales developed by Diener (SWLS) and the Canadian Community Health Survey (CCHS-SWL). The mean values for the Mental Component Score of SF12 (p = 0.002), SWLS (p < 0.001), and CCHS-SWL (p = 0.044) significantly worsened after WT operation for those participants who had a negative attitude to WTs, who voiced concerns about property devaluation, and/or who reported being visually or noise annoyed.

  15. Engaging life in two Irish nursing home units for people with dementia: Quantitative comparisons before and after implementing household environments.

    LENUS (Irish Health Repository)

    Morgan-Brown, Mark

    2012-09-03

    Objectives: This study compares the Social Engagement and Interactive Occupation of residents with dementia in two Irish nursing homes, before and after conversion to a household model environment. The changes were an open plan design and a functioning unit kitchen, supported by a homemaker role and operational policies which reduced task-based work in favour of person-centred care offering choice. Method: A snapshot observation method was used to obtain quantitative data of resident activity using the Assessment Tool for Occupation and Social Engagement (ATOSE). Residents were assessed for four hours, on seven different weekdays, over a six-week period both pre- and post-renovation. The exception to this was the assessment of the traditional model unit (TMU) for Nursing Home 1 which was reduced to four days due to the early start of the building work. Results: The results were consistent for both nursing homes and data were aggregated. Residents spent more time in the communal living spaces and were more likely to be active and engaged in the household model units (HMUs) compared to the TMUs. Using the independent t-test, these changes were found to be highly significant (p < 0.001). Conclusion: Creating an HMU increased the Interactive Occupation and Social Engagement of residents in the communal areas of the two nursing homes. The physical environment change, in conjunction with supportive staff procedures and organizational initiatives, improved the well-being of residents with dementia. The outcomes must be viewed in context with financial implications.

  16. Changes in quality of life and perceptions of general health before and after operation of wind turbines.

    Science.gov (United States)

    Jalali, Leila; Bigelow, Philip; McColl, Stephen; Majowicz, Shannon; Gohari, Mahmood; Waterhouse, Ryan

    2016-09-01

    Ontario is Canada's provincial leader in wind energy, with over 4000 MW of installed capacity supplying approximately five percent of the province's electricity demand. Wind energy is now one of the fastest-growing sources of renewable power in Canada and many other countries. However, its possible negative impact on population health, as a new source of environmental noise, has raised concerns for people living in proximity to wind turbines (WTs). The aims of this study were to assess the effect of individual differences and annoyance on the self-reported general health and health-related quality of life (QOL) of nearby residents, using a pre- and post-exposure design. Prospective cohort data were collected before and after WT operations, from the individuals (n = 43) in Ontario, Canada. General health and QOL metrics were measured using standard scales, such as SF12, life satisfaction scales developed by Diener (SWLS) and the Canadian Community Health Survey (CCHS-SWL). The mean values for the Mental Component Score of SF12 (p = 0.002), SWLS (p < 0.001), and CCHS-SWL (p = 0.044) significantly worsened after WT operation for those participants who had a negative attitude to WTs, who voiced concerns about property devaluation, and/or who reported being visually or noise annoyed. PMID:27321878

  17. Gallbladder motility in patients with hepatic cirrhosis before and after portal azygous disconnection

    Institute of Scientific and Technical Information of China (English)

    Hong-Xu Jin; Shuo-Dong Wu; Xue-Feng Zhang; Xian-Ying Chen; Guo-Xu Zhang

    2004-01-01

    AIM: To determine and compare the effect of vagus nerve on gallbladder motility in patients with hepatic cirrhosis before and after portal azygous disconnection (PAD).METHODS: PAD operation (or Hassab's operation) was performed on 18 patients with portal hypertension, and anterior and posterior vagal trunks were cut. On d 3 before operation and d 10 after operation, 99mTc-EHIDA 185 MBq was administered intravenously to the patients, and scintigraphy was performed at 0.25 min/frame. A standard fat meal was administered 30 min after scintigraphy, and dynamic imaging was performed 60 min after the fat meal.Following appearance of the region of interest (ROI) in gallbladder, the time-activity curve of ROI was established.The following seven parameters were used: radioactivity at 30 min after injection of 99mTc-EHIDA (RC 30min), bile emptying fraction (EF), bile emptying period (EP), emptying rate (ER), latent period (LP), latent period radiocounting increment (LI), and latent period radiocounting increment rate (LR).RESULTS: The RC 30 min decreased significantly after operation,compared with that before operation (2 693.6± 2 406.9 vs 5 606.8±2 625.4, P<0.05). The radiocounting of gallbladder increased gradually during LP. LP after operation was significantly longer than that before operation (13.36±5.92 vs 2.24± 1.48,P<0.01). LI and LR after operation were significantly higher than those before operation (2 861.62±028.3 vs 331.21±421.02, and 113.42±49.52 vs7.57±10.75,respectively, both P<0.01). EP after operation was significantly shorter than that before operation (18.5±6.3vs 24.1±6.4, P<0.05). EF and ER after operation were significantly lower than those before operation (13.1±5.4vs32.3±16.3, and 0.7±0.3 vs 1.4±0.8, respectively, both P<0.01).CONCLUSION: PAD operation is a good clinical model in studying the effect of vagus on gallbladder motility. The gallbladder tension after PAD operation decreases significantly during the interdigestive

  18. Lava flow hazard at Fogo Volcano, Cabo Verde, before and after the 2014-2015 eruption

    Science.gov (United States)

    Richter, Nicole; Favalli, Massimiliano; de Zeeuw-van Dalfsen, Elske; Fornaciai, Alessandro; da Silva Fernandes, Rui Manuel; Pérez, Nemesio M.; Levy, Judith; Silva Victória, Sónia; Walter, Thomas R.

    2016-08-01

    Lava flow simulations help to better understand volcanic hazards and may assist emergency preparedness at active volcanoes. We demonstrate that at Fogo Volcano, Cabo Verde, such simulations can explain the 2014-2015 lava flow crisis and therefore provide a valuable base to better prepare for the next inevitable eruption. We conducted topographic mapping in the field and a satellite-based remote sensing analysis. We produced the first topographic model of the 2014-2015 lava flow from combined terrestrial laser scanner (TLS) and photogrammetric data. This high-resolution topographic information facilitates lava flow volume estimates of 43.7 ± 5.2 × 106 m3 from the vertical difference between pre- and posteruptive topographies. Both the pre-eruptive and updated digital elevation models (DEMs) serve as the fundamental input data for lava flow simulations using the well-established DOWNFLOW algorithm. Based on thousands of simulations, we assess the lava flow hazard before and after the 2014-2015 eruption. We find that, although the lava flow hazard has changed significantly, it remains high at the locations of two villages that were destroyed during this eruption. This result is of particular importance as villagers have already started to rebuild the settlements. We also analysed satellite radar imagery acquired by the German TerraSAR-X (TSX) satellite to map lava flow emplacement over time. We obtain the lava flow boundaries every 6 to 11 days during the eruption, which assists the interpretation and evaluation of the lava flow model performance. Our results highlight the fact that lava flow hazards change as a result of modifications of the local topography due to lava flow emplacement. This implies the need for up-to-date topographic information in order to assess lava flow hazards. We also emphasize that areas that were once overrun by lava flows are not necessarily safer, even if local lava flow thicknesses exceed the average lava flow thickness. Our

  19. Single photon emission computed tomography (SPECT of anxiety disorders before and after treatment with citalopram

    Directory of Open Access Journals (Sweden)

    Seedat Soraya

    2004-10-01

    Full Text Available Abstract Background Several studies have now examined the effects of selective serotonin reuptake inhibitor (SSRI treatment on brain function in a variety of anxiety disorders including obsessive-compulsive disorder (OCD, posttraumatic stress disorder (PTSD, and social anxiety disorder (social phobia (SAD. Regional changes in cerebral perfusion following SSRI treatment have been shown for all three disorders. The orbitofrontal cortex (OFC (OCD, caudate (OCD, medial pre-frontal/cingulate (OCD, SAD, PTSD, temporal (OCD, SAD, PTSD and, thalamic regions (OCD, SAD are some of those implicated. Some data also suggests that higher perfusion pre-treatment in the anterior cingulate (PTSD, OFC, caudate (OCD and antero-lateral temporal region (SAD predicts subsequent treatment response. This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed treatment response across anxiety disorders with SSRI treatment. Methods Single photon emission computed tomography (SPECT using Tc-99 m HMPAO to assess brain perfusion was performed on subjects with OCD, PTSD, and SAD before and after 8 weeks (SAD and 12 weeks (OCD and PTSD treatment with the SSRI citalopram. Statistical parametric mapping (SPM was used to compare scans (pre- vs post-medication, and responders vs non-responders in the combined group of subjects. Results Citalopram treatment resulted in significant deactivation (p = 0.001 for the entire group in the superior (t = 4.78 and anterior (t = 4.04 cingulate, right thalamus (t = 4.66 and left hippocampus (t = 3.96. Deactivation (p = 0.001 within the left precentral (t = 4.26, right mid-frontal (t = 4.03, right inferior frontal (t = 3.99, left prefrontal (3.81 and right precuneus (t= 3.85 was more marked in treatment responders. No pattern of baseline activation distinguished responders from non-responders to subsequent pharmacotherapy. Conclusions Although each of the anxiety disorders may be mediated by different

  20. Carbon uptake before and after the felling of an Eucalyptus forest

    Science.gov (United States)

    Pita, Gabriel; Rodrigues, Abel; Mateus, Joao; Santos Pereira, Joao

    2010-05-01

    Espirra site (38°38'N,8°36'W) is located in a 300ha Eucalyptus globulus plantation, with a Mediterranean type climate with a mean annual precipitation of 709mm and a mean annual air temperature of 15.9°C. The plantation was established in 1986 with about 1100 trees ha-1. A 33m observation tower was installed in 2002, with an eddy covariance system. A harvesting of trees was made at the end of the 2nd rotation period, from November to December 2006. During the last four years of the second rotation the coppice were 20m height. Harvesting was planned in order to initiate a new 12 year productive cycle. In October 2008 a first thinning was made in three fourths of emerging stems from stumps. At this stage the forest trees had a mean height of 6m. during the period of analyses the total annual precipitation has varied between a minimum of 248mmYr-1 (2005) to a maximum of 796mm Yr-1 (2007), pattern typical of a Mediterranean climate. The diminution of precipitation (and also how it is distributed along the year) affects the forest uptake of Carbon .The GPP and the Reco show lower values in dry years, both in the adult forest as in the young one. The GPP of the growing eucalyptus has been affected by the dry year but also by the thinning that took place in Oct 2008. The Ecosystem total respiration shows high values after the felling ( the same order of magnitude as the forest before the felling) due to the leaves and branches that were left over the soil after the harvesting. Three years after the felling the GPP of the young forest is 61% the value of the adult forest (mean value, excluding the dry year). The seasonal pattern of RECO is similar before and after the felling, but in the young forest the GPP is lower and the NEE becomes positive in the summer time. In an annual base the growing eucalyptus forest only in the first year after felling was a source of carbon.

  1. Oxygen Oases Before and After the GOE: Insights From Metals and Models

    Science.gov (United States)

    Olson, S. L.; Reinhard, C. T.; Planavsky, N. J.; Lyons, T. W.; Roy, M.; Anbar, A. D.

    2014-12-01

    The evolution of oxygenic photosynthesis fundamentally changed the structure of the marine biosphere and the chemistry of Earth's ocean-atmosphere system. Atmospheric oxygenation, however, was decoupled from the onset of biological O2 production—possibly lagging by as much as half a billion years—and O2 remained low for two billion years following initial O2 accumulation. Although uncertainties remain regarding the fate of biogenic O2 during the Precambrian, it is becoming clear that the consequences of oxygenesis were both spatially and temporally variable. Several lines of evidence support the existence of aerobic ecosystems associated with O2 oases within an otherwise anoxic Archean ocean; however—with notable exceptions—atmospheric O2 remained low enough to severely curtail oxidative weathering processes on long-term average throughout the Archean. During the subsequent Great Oxidation Event (GOE) in the early Paleoproterozoic, atmospheric O2 irreversibly increased above the sensitivity thresholds of several well-established proxies, but the level at which O2 eventually stabilized remains unclear. Consequently, the dynamics of O2 cycling are poorly characterized both before and after the GOE. Nevertheless, recent analytical and numerical results suggest exceptionally low O2 levels that may have favored Archean-style O2 oases in the mid-Proterozoic. We used Fe speciation and trace metal records from Precambrian shales, including data from two new cores that target the 2.7 Ga Roy Hill Shale, to investigate pre- and post- GOE redox heterogeneity in Earth's surface environments. Fe speciation supports the reconstruction of local marine redox conditions, and, in this context, trace metals can allow glimpses of redox conditions beyond the local environment, which may have throttled the supply of key redox-sensitive trace metals to the ocean. Then, using O2 constraints derived from these inorganic proxies, we use an Earth System model to explore C, O, and

  2. Expression of sIL-2R before and after Chemotherapy in Patients with Breast Cancer

    Institute of Scientific and Technical Information of China (English)

    FAN Yuan-ming; SUN Zhi-jun

    2008-01-01

    Objective:To investigate the difference of peripheral blood sIL-2R before and after chemotherapy in breast cancer patients,and evaluate the clinical value of the sIL-2R in breast cancer's diagnosis and therapy.Methods:The peripheral blood sIL-2R levels of the breast cancer patients with or without chemotherapy were detected by ELISA.The healthy persons were made as the control group.Results:The slL-2R levels of the breast cancer patients were higher than that of the control group(P<0.05);the slL-2R's levels in Ⅰ~Ⅱ stage breast cancer were lower than that in Ⅲ~Ⅳ stag e breast cancer (P<0.05);the sIL-2R levels of the patients before chemotherapy were higher than that of the patients undergone chemotherapy(P<0.05);The level of the patient with chemotherapy was still higher than that of the control group(P<0.05);the sIL-2R levels of the patients whose chemotherapies were noneffective were higher than that of the patients received effective chemotherapies(P<0.05).There was no significant difference between the group with ER(+)or PR(+)and the group with ER(-)or PR(-)(P>0.05).Conclusion:The breast cancer patients have the high slL-2R levels.There is a close relationship between the cancer incidence and the patients,immune situation.The level of slL-2R could be a clinical index which Can be used for evaluating the cancer degree,because the higher levels of slL-2R can indicate that the immune ability of patient is worse.There is a significant difference between the slL-2R levels of the patients before chemotherapy and that of the patients undergone chemotherapy.

  3. Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy

    Institute of Scientific and Technical Information of China (English)

    Anna Zub-Pokrowiecka; Kazimierz Rembiasz; Peter C Konturek; Andrzej Budzyński; Stanis(l)aw J Konturek; Marek Winiarski; W(l)adys(l)aw Bielański

    2011-01-01

    AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori ) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori -negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcriptionpolymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori -positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients

  4. Depression and anxiety before and after percutaneous coronary intervention and their relationship to age

    Institute of Scientific and Technical Information of China (English)

    Zhiyong Zhao; Jing Luo; Jianmei Wang; Yan Su

    2008-01-01

    Percutaneous coronary intervention (PCI) is becoming a common practice in the treatment of patients with coronary heart disease (CHD) of all age.Depression is considered to be a risk factor for the development of CHD and deteriorates the outcome after cardiac rehabilitation efforts.The aim of our study was to evaluate the presence of clinically relevant anxiety and depression in patients before and after PCI.Additionally we evaluated their relationship to age because of the increasing number of elderly patients undergoing PCI.Methods One hundred and twelve consecutive patients in three Sanatoria for Retired Cadres in Beijing who underwent PCI were asked to fill in the Hospital Anxiety and Depression Scale (HADS) to measure depression and anxiety scores two days before and ten days after PCI.Differences between these pre- and post-surgical scores were then calculated as means for changes,and the amount of elevated scores was appraised,in order to investigate the relationship between age and anxiety and depression,respectively,Spearman correlations between age and the difference scores were calculated.In addition,ANOVA procedures with the factor "age group" and McNemar tests were calculated.Results 25.8% of the patients were clinically depressed before and 17.5% after PCI;34.0% of the patients were clinically anxious before and 24.7% after PCI.This overall change is not significant.We found a significant negative correlation between age and the difference between the two time points for anxiety (Spearman rho = -.218,P = 0.03),but not for depression (Spearman rho = -.128,P = 0.21).ANOVA and McNemar tests revealed that anxiety scores and the number of patients high in anxiety declined statistically meaningful only in the youngest patient group.Such a relationship could not be found for depression.Conclusions Our data show a relationship between age and anxiety.Younger patients are more anxious before PCI than older ones and show a decline in symptoms while elderly

  5. Analysis of diaphragmatic movement before and after pulmonary rehabilitation using fluoroscopy imaging in patients with COPD

    Directory of Open Access Journals (Sweden)

    Chun EM

    2015-01-01

    Full Text Available Eun Mi Chun,1 Soo Jeong Han,2 Hitesh N Modi3 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul, Republic of Korea; 2Rehabilitation Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea; 3Scoliosis Research Institute, Department of Orthopedics, Korea University Guro Hospital, Seoul, Republic of Korea Background: The diaphragm is the principal inspiratory muscle. The purpose of this study was to assess improvements in diaphragmatic movement before and after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD, using a fluoroscopy-guided chest X-ray.Patients and methods: Among 117 patients with COPD receiving pulmonary rehabilitation who underwent the initial fluoroscopy-guided chest X-ray and pulmonary function test, 37 of those patients who underwent both initial and follow-up fluoroscopy and pulmonary function tests were enrolled in this study. After hospital education, participants received pulmonary rehabilitation through regular home-based training for at least 3 months by the same physiatrist. We assessed the changes in diaphragm area with fluoroscopy-guided posteroanterior chest X-rays between pre- and postpulmonary rehabilitation. To minimize radiation hazards for subjects, the exposure time for fluoroscopy to take chest X-rays was limited to less than 5 seconds.Results: There were significant improvements (2,022.8±1,548.3 mm² to 3,010.7±1,495.6 mm² and 2,382.4±1,475.9 mm² to 3,315.9±1,883.5 mm²; right side P=0.001 and left side P=0.019, respectively in diaphragmatic motion area during full inspiration and expiration in both lungs after pulmonary rehabilitation. Pulmonary function tests showed no statistically significant difference between pre- and postpulmonary rehabilitation.Conclusion: The study suggests that the strategy to assess diaphragm movement using fluoroscopy is a relatively effective tool for the evaluation of pulmonary

  6. The applied observation of ultrasonography on before and after anti-early pregnancy with mifepristone (reports of 660 cases)

    International Nuclear Information System (INIS)

    Objective: To estimate the clinical significance of ultrasonography on before and after anti-early pregnancy with mifepristone. Methods: 660 cases of premedical abortion were ultrasonic diagnosed to know the status of inner-uterus pregnancy and exclude the taboo of medical abortion; after-medical abortion ultrasonic were performed to find rudimental embryo in uterus, recuperation of uterus, etc. Results: 88.18% of cases are full abortion; 10.15% of cases are semi-abortion; 1.7% of cases are unsuccessful abortion. Conclusions: It is a quick and safe method to use ultrasonography before and after medical abortion. (authors)

  7. Effectiveness of a 1-Year Resident Training Program in Clinical Research: A Controlled Before-and-After Study

    Science.gov (United States)

    Hartmann, Mechthild; Wild, Beate; Nikendei, Christoph; Kroenke, Kurt; Niehoff, Dorothea; Henningsen, Peter; Zipfel, Stephan; Herzog, Wolfgang

    2007-01-01

    Background To increase the number of clinician scientists and to improve research skills, a number of clinical research training programs have been recently established. However, controlled studies assessing their effectiveness are lacking. Objective To investigate the effectiveness of a 1-year resident training program in clinical research. Design Controlled before-and-after study. The training program included a weekly class in clinical research methods, completion of a research project, and mentorship. Participants Intervention subjects were 15 residents participating in the 1-year training program in clinical research. Control subjects were 22 residents not participating in the training program. Measurements and Main Results Assessments were performed at the beginning and end of the program. Outcomes included methodological research knowledge (multiple-choice progress test), self-assessed research competence, progress on publications and grant applications, and evaluation of the program using quantitative and qualitative methods. Results Intervention subjects and controls were well matched with respect to research experience (5.1 ± 2.2 vs 5.6 ± 5.8 years; p = .69). Methodological knowledge improved significantly more in the intervention group compared to the control group (effect size = 2.5; p < .001). Similarly, self-assessed research competence increased significantly more in the intervention group (effect size = 1.1; p = .01). At the end of the program, significantly more intervention subjects compared to controls were currently writing journal articles (87% vs 36%; p = .003). The intervention subjects evaluated the training program as highly valuable for becoming independent researchers. Conclusions A 1-year training program in clinical research can substantially increase research knowledge and productivity. The program design makes it feasible to implement in other academic settings. PMID:17922168

  8. Comparison of Blood Cholesterol Profiles Before and After The Measurements of Maximum Aerobic Capacity (VO2max

    Directory of Open Access Journals (Sweden)

    Ar Rasyid Shadiqin

    2013-11-01

    Full Text Available This study is aimed to compare the blood cholesterol profile, before and after the measurement of maximum aerobic capacity (VO2max in the students of Jurusan Pendidikan Olahraga dan Kesehatan (JPOK pada Fakultas Keguruan dan Ilmu Pendidikan (FKIP Universitas Lambung Mangkurat Banjarmasin.Variables in this study consist of lipid profiles, including total cholesterol, high density lipoprotein (HDL, low density lipoprotein (LDL, triglyceride (TG and Maximum Aerobic Capacity (VO2max. The concept of VO2max according to Kent(1994:268: “maximum oxygen volume consumed per minute to show total work capacity, or volume per minute relative to body weight (ml/kg.min”. Operationally, VO2max referred in this study is the maximum volume of oxygen that can be consumed per minute, as measured at progressive run (Bleep Test.The method used in this study is pre-experimental with one group pretest-posttest design. This design implies that a group of subjects are treated for a specific period and the measurements are taken both pre and post.The results: There are changes in blood cholesterol profile after the measurement of maximum oxygen capacity (VO2max, shown by significant decrease of total cholesterol variable, increased HDL, and decreased LDL. Changes in triglyceride variable showed no significant decrease despite the statistic differences. Specific HDL sub-class increasing after exercise is a constructive lipoprotein sub-class whereas LDL is destructive lipoproteins sub-class that might damage the body. Therefore, an increase in HDL and decrease in LDL found in this study appears to be advantageous and consequently might alter the risk of coronary heart disease.

  9. Concentrations of cardiac Troponin I before and after ovariohysterectomy in 46 female dogs with pyometra

    Directory of Open Access Journals (Sweden)

    Hagman Ragnvi

    2008-09-01

    total, 20 dogs (43% had increased pre- or postoperative cTnI concentrations. Seven dogs (15% had pre-or postoperative concentrations of cTnI of 1.0 μg/l or higher. Conclusion Mild to moderate increases in cTnI appears to be common in dogs with pyometra before and after surgery, but the clinical importance of this finding is uncertain. None of the studied clinical variables were found to reliably predict increased preoperative cTnI concentrations. Because of the pre- and postoperative variation in cTnI concentrations, it was not possible to identify a negative effect of anaesthesia and surgery on myocardial cell integrity.

  10. Epidemiology of birth defects, perinatal mortality and thyroid cancer before and after the Chernobyl catastrophe

    International Nuclear Information System (INIS)

    Spatial and temporal trends of birth defects and perinatal mortality in Germany and Europe as well as in least and most contaminated regions have been compared and investigated by trends. In numerous data sets, especially from northern and eastern Europe, positive and significant trend variations with upward 'disturbances' in temporal relation associated with the Chernobyl accident 1986 have been identified and spatial associations with regional fallout have been found. A surprisingly consistent picture evolves of significantly raised stillbirth rates after Chernobyl of ca. 5 % in Poland, ca. 10 % in parts of Germany and Sweden, ca. 20 % in Denmark and Finland, and up to ca. 30% in Iceland and Hungary. Low as compared to higher contaminated regions show weaker or stronger effects, respectively. The additional relative risks for birth defects are in the same order of magnitude as the additional relative risks for stillbirth, namely 0,5%-20 %/kBq·m2. Using well-known conversion coefficients, the excess relative risk of 1 %/kBq·m2 translates theoretically to a preliminary relative risk of 1,6/mSv/a. The incidence of thyroid carcinoma among children affected by Chernobyl fallout has increased dramatically in certain parts of Europe. Less evidence exists for a similar effect among adolescents and adults. The cancer registry of the Czech Republic provides an opportunity to study various determinants of the occurrence of thyroid cancer. After the Chernobyl accident, the thyroid cancer incidence of the Czech Republic reveals an additional annual increase of up to 5% depending on age and gender. The additional increases of thyroid cancer in the whole population of the Czech Republic are consistent with reports from other countries. To investigate trends in the sex distribution of newborns before and after the Chernobyl accident, gender-specific annual birth statistics were obtained from the Czech Republic, Denmark, Finland, Germany, Hungary, Norway, Poland, and Sweden

  11. Disposition of Patients Before and After Establishment of Emergency Medicine Specialists

    Directory of Open Access Journals (Sweden)

    Payman Asadi

    2014-09-01

    hospitalization mean of the patient has remarkably decreased from 1.08±0.44 days to 0.35±0.05 days in 2009-2012 (p=0.021. The occupied bed mean before and after the presence of emergency medicine specialists were 12173±3453 and 6217±219, respectively, showed a descending trend into the past (p=0.018. Conclusion: It seems that presenting of emergency medicine specialists in health system leads to improve the service delivery to patients and decrease the waiting time.  Also with decreasing the waiting time of patients and timely disposition, more prepared beds can be accessible in the ED for future admission.

  12. Before and after the earthquake: a case study of attrition from the HIV antiretroviral therapy program in Haiti

    Directory of Open Access Journals (Sweden)

    Nancy H. Puttkammer

    2014-08-01

    Full Text Available Background: On January 12, 2010, a devastating 7.0 magnitude earthquake struck the West Department of Haiti, killing more than 200,000 people and injuring or displacing many more. This disaster threatened continuity of HIV care and treatment services. Objectives: This case study examined the effect of the devastating 2010 earthquake in Haiti on attrition from the HIV antiretroviral therapy (ART program. Design: The study triangulated retrospective data from existing sources, including: 1 individual-level longitudinal patient data from an electronic medical record for ART patients at two large public sector departmental hospitals differently affected by the earthquake; and 2 aggregate data on the volume of HIV-related services delivered at the two hospitals before and after the earthquake. Methods: The study compared ART attrition and service delivery in Jacmel, a site in the ‘very strong’ zone of earthquake impact, and in Jérémie, a site in the ‘light’ zone of earthquake impact. The analysis used time-to-event analysis methods for the individual-level patient data, and descriptive statistical methods for the aggregate service delivery data. Results: Adjusted ART attrition risk was lower at the hospital in Jacmel after vs. before the earthquake (HR=0.51; p=0.03, and was lower in Jacmel vs. Jérémie both before (HR=0.55; p=0.01 and after the earthquake (HR=0.35; p=0.001. The number of new ART patient enrollments, new HIV patient registrations, and HIV clinical visits dropped notably in Jacmel immediately after the earthquake, but then rapidly rebounded. On average, there was no change in new ART enrollments per month after vs. before the earthquake at either site. Conclusion: These findings underscore the resilience of Haitian ART providers and patients, and contribute evidence that it is possible to maintain continuity of ART services even in the context of a complex humanitarian crisis.

  13. Pathways into homelessness: recently homeless adults - problems and service use before and after becoming homeless in Amsterdam

    NARCIS (Netherlands)

    I.R. van Laere; M.A. de Wit; N.S. Klazinga

    2009-01-01

    ABSTRACT: OBJECTIVE: To improve homelessness prevention practice, we met with recently homeless adults, to explore their pathways into homelessness, problems and service use, before and after becoming homeless. METHODS: Recently homeless adults (last housing lost up to two years ago and legally stay

  14. Senior Medical Students' Attitudes toward Psychiatry as a Career Choice before and after an Undergraduate Psychiatry Internship in Iran

    Science.gov (United States)

    Amini, Homayoun; Moghaddam, Yasaman; Nejatisafa, Ali-Akbar; Esmaeili, Sara; Kaviani, Hosein; Shoar, Saeed; Shabani, Amir; Samimi-Ardestani, Mehdi; Akhlaghi, Amir Abbas Keshavarz; Noroozi, Alireza; Mafi, Mostafa

    2013-01-01

    Objectives: The study aimed to assess 1) the attitudes of medical students in the sixth and seventh years (known as interns in Iran) toward psychiatry as a career choice, and 2) the degree of attractiveness of psychiatry as a career choice, with regard to various defined aspects, before and after an undergraduate psychiatry internship (similar to…

  15. Head injury resulting from scooter accidents in Rome: Differences before and after implementing a universal helmet law

    NARCIS (Netherlands)

    G. La Torre (Giuseppe); E.F. van Beeck (Ed); G. Bertazzoni (Giuliano); W. Ricciardi

    2007-01-01

    textabstractObjectives: To estimate the incidence rates and related determinants of head injuries before and after the implementation of a new universal helmet law in Italy. Methods: The investigation took place in the Emergency Room of the Accident and Emergency Department, Teaching Hospital 'Umber

  16. Publication Productivity among Doctoral Graduates of Educational Psychology Programs at Research Universities before and after the Year 2000

    Science.gov (United States)

    Barnard-Brak, Lucy; Saxon, Terrill F.; Johnson, Heather

    2011-01-01

    Research suggests that new doctoral graduates face increased publication pressure to achieve tenure: doctoral programs may have also increased this expectation. We examined whether faculty graduating before and after the year 2000 differed significantly in total publications, peer-reviewed publications, and first-authored publications as of the…

  17. A Comparative Study of Pre-Service Teachers' Self-Efficacy Beliefs before and after Work-Integrated Learning

    Science.gov (United States)

    Matoti, S. N.; Junqueira, K. E.; Odora, R. J.

    2011-01-01

    The purpose of the study was to compare the teaching efficacy beliefs of pre-service teachers before and after work-integrated learning (WIL) in a South African University of Technology. The comparison groups were formed based on the criterion of WIL. Pre-service teachers in their third year of the B.Ed. (FET) programme participated in the study…

  18. A Comparative Study of Pre-Service Teachers' Teaching Efficacy Beliefs before and after Work-Integrated Learning: Part Two

    Science.gov (United States)

    Junqueira, K. E.; Matoti, S. N.

    2013-01-01

    The study, which is grounded in Bandura's concept of self-efficacy, assessed the teaching efficacy beliefs of student teachers before and after completing six months of work-integrated learning. This was necessitated by research which shows that self-efficacy is an important aspect which influences a teacher's ability to teach as well as the…

  19. Use of Cough and Cold Medications in Severe Bronchiolitis Before and After a Health Advisory Warning against Their Use

    Science.gov (United States)

    O’Donnell, Katherine; Mansbach, Jonathan M.; LoVecchio, Frank; Cheng, John; Piedra, Pedro A.; Clark, Sunday; Sullivan, Ashley F.; Camargo, Carlos A.

    2015-01-01

    We compared the use of cough and cold medications in two multicenter studies of young children hospitalized with bronchiolitis before and after the 2008 Food and Drug Administration cough and cold medications advisory. Although cough and cold medications use decreased after the advisory, nearly 20% of children age 12–23.9 months with severe bronchiolitis received cough and cold medications. PMID:25888349

  20. Schooling in Violent Situations: The Politicization of Education in Nepal, before and after the 2006 Peace Agreement

    Science.gov (United States)

    Pherali, Tejendra J.

    2013-01-01

    This article examines the contentious relationship between education and the Maoist insurgency in Nepal, analyzing the political intrusion on the education sector before and after the multi-party polity was restored in 1990, and the violent experiences of teachers and students during the decade-long conflict (1996-2006). It argues that the end of…

  1. Fetal ductus venosus flow velocity waveforms and maternal serum AFP before and after first-trimester transabdominal chorionic villus sampling

    NARCIS (Netherlands)

    C.A. Brezinka (Christoph); A.M. Hagenaars (A.); J.W. Wladimiroff (Juriy); F.J. Los

    1995-01-01

    textabstractDoppler flow velocity waveform recording in the fetal ductus venosus and umbilical artery as well as maternal blood sampling for serum alpha-fetoprotein (MSAFP) was performed before and after transabdominal chorion villus sampling (TACVS) in 36 women of advanced maternal age (≥ 36 years)

  2. Affect Intensity and Phasic REM Sleep in Depressed Men before and after Treatment with Cognitive-Behavioral Therapy.

    Science.gov (United States)

    Nofzinger, Eric A.; And Others

    1994-01-01

    Explored relationship between daytime affect and REM (rapid eye movement) sleep in 45 depressed men before and after treatment with cognitive-behavioral therapy and in control group of 43 healthy subjects. For depressed subjects only, intensity of daytime affect correlated significantly and positively with phasic REM sleep measures at pre- and…

  3. Participation in Society in Patients With Coronary Artery Disease Before and After Cardiac Rehabilitation

    NARCIS (Netherlands)

    ter Hoeve, Nienke; van Geffen, Myrna E.; Post, Marcel W.; Stam, Henk J.; Sunamura, Madoka; van Domburg, Ron T.; van den Berg-Emons, Rita J.

    2015-01-01

    Objectives: To assess changes in participation in society (frequency, restrictions, satisfaction) during and after cardiac rehabilitation (CR) and to assess associations between participation and heath-related quality of life (HRQOL). Design: Prospective cohort study. Setting: Outpatient CR center.

  4. Comparison of the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences

    Directory of Open Access Journals (Sweden)

    MASOUMEH DELARAM

    2014-01-01

    Full Text Available Introduction: Inappropriate advice interferes with the students’ achievement of educational and professional goals and they may fail to use proper resources for their educational needs. The present study was carried out to compare the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences. Methods: This longitudinal study was carried out using census report on 244 students in different courses at Shahrekord University of Medical Sciences in two stages at the first semester of 2010-2011 and first semester of 2011-2012. To collect the data, we used a self-designed questionnaire including individual and educational information and 10 multiple-choice questions with Likert scale to assess the students’ satisfaction about the advisors’ performance. Data were analyzed in SPSS 14 using paired t-test, qui-square test. P<0.05 was considered significant. Results: Of the ten items of satisfaction, there was only a significant difference in “accessibility to an advisor before and after the advisor project in students of nursing and midwifery school” (p=0.010, and the difference was not significant in other items in these students. No significant difference was found in ten items of satisfaction in students at other schools before and after the advisor project (p=0.010. Conclusion: It seems that the implementation of advisor project could not provide a satisfactory position for students. Adequate supervision of university officials on proper implementation of the advisor project, supporting faculty advisors and strengthening their position can help to improve the process.

  5. Stroke rehabilitation at home before and after discharge reduced disability and improved quality of life

    DEFF Research Database (Denmark)

    Rasmussen, Rune Skovgaard; Østergaard, Ann; Kjær, Pia;

    2016-01-01

    OBJECTIVE: To evaluate if home-based rehabilitation of inpatients improved outcome compared to standard care. DESIGN: Interventional, randomised, safety/efficacy open-label trial. SETTING: University hospital stroke unit in collaboration with three municipalities. SUBJECTS: Seventy-one eligible s...... and increased quality of life. Compared to standard care, home-based stroke rehabilitation was more cost-effective....

  6. Straylight before and after hyperopic laser in situ keratomileusis or laser-assisted subepithelial keratectomy

    NARCIS (Netherlands)

    R. Lapid-Gortzak; J.W. van der Linden; I.J.E. van der Meulen; C.P. Nieuwendaal; M.P. Mourits; T.J.T.P. van den Berg

    2010-01-01

    PURPOSE To compare straylight values before and 3 months after hyperopic laser in situ keratomileusis (LASIK) or laser-assisted subepithelial keratectomy (LASEK) and determine the cause of any change SETTING Private refractive surgery clinic, Driebergen, The Netherlands DESIGN Comparative case serie

  7. Biocide and antibiotic susceptibility of Salmonella isolates obtained before and after cleaning at six Danish pig slaughterhouses

    DEFF Research Database (Denmark)

    Gantzhorn, Mette Rørbæk; Pedersen, Karl; Olsen, John Elmerdahl;

    2014-01-01

    that bacteria exposed to disinfectants can develop resistance toward disinfectants and can have a higher risk of developing antibiotic resistance.The objectives of this study were to examine the prevalence of biocide resistant Salmonella sp. in Danish pig slaughterhouses, to evaluate if there was a correlation....... The susceptibility toward three different biocides, triclosan and two commercial disinfection products: Desinfect Maxi, a quaternary ammonium compound, and Incimaxx DES, an acetic compound, was determined. We found no resistance toward the biocides tested, but we did find that isolates obtained after cleaning had...... that there was a weak statistical correlation between MICs toward the biocides and some antibiotics, but no difference in log(MIC)s toward antibiotics between isolates obtained before and after cleaning, nor did we find any difference in the number of resistances of isolates obtained before and after cleaning...

  8. Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K.M.; Chapman, R.S.; Shen, M.; Lubin, J.H.; Silverman, D.T.; He, X.; Hosgood, H.D.; Chen, B.E.; Rajaraman, P.; Caporaso, N.E.; Fraumeni, J.F.; Blair, A.; Lan, Q. [NCI, Bethesda, MD (USA)

    2010-08-24

    In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement. We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.

  9. Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

    Science.gov (United States)

    Lee, K-M; Chapman, R S; Shen, M; Lubin, J H; Silverman, D T; He, X; Hosgood, H D; Chen, B E; Rajaraman, P; Caporaso, N E; Fraumeni, J F; Blair, A; Lan, Q

    2010-01-01

    Background: In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods: We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement. Results and conclusion: We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure. PMID:20648014

  10. Use of Health Care Services Before and After a Natural Disaster Among Survivors With and Without PTSD

    DEFF Research Database (Denmark)

    Rosendal, Susanne; Mortensen, Erik Lykke; Andersen, Henrik Steen;

    2014-01-01

    . METHODS Ten months after the December 26, 2004, Southeast Asian tsunami, Danish tourists who had been in areas exposed to the disaster were mailed a questionnaire asking about demographic characteristics and exposure to the tsunami. The questionnaire included the PTSD Checklist, which measures symptoms...... on annual number of contacts with health care services before (2002-2004) and after (2005-2007) the tsunami. RESULTS Survivors with PTSD or partial PTSD used health care services more than survivors without PTSD before and after the tsunami. The severity of posttraumatic stress symptoms was positively......OBJECTIVE This study used a questionnaire to identify individuals who met criteria for posttraumatic stress disorder (PTSD) ten months after surviving a disaster and compared their use of health care services before and after the disaster with that of survivors who did not meet criteria for PTSD...

  11. Analysis by NASA's VESGEN Software of Retinal Blood Vessels Before and After 70-Day Bed Rest: A Retrospective Study

    Science.gov (United States)

    Raghunandan, Sneha; Vyas, Ruchi J.; Vizzeri, Gianmarco; Taibbi, Giovanni; Zanello, Susana B.; Ploutz-Snyder, Robert; Parsons-Wingerter, Patricia A.

    2016-01-01

    Significant risks for visual impairment associated with increased intracranial pressure (VIIP) are incurred by microgravity spaceflight, especially long-duration missions. Impairments include decreased near visual acuity, posterior globe flattening, choroidal folds, optic disc edema and cotton wool spots. We hypothesize that microgravity-induced fluid shifts result in pathological changes within the retinal blood vessels that precede development of visual and other ocular impairments. Potential contributions of retinal vascular remodeling to VIIP etiology are therefore being investigated by NASAs innovative VESsel GENeration Analysis (VESGEN) software for two studies: (1) head-down tilt in human subjects before and after 70 days of bed rest, and (2) U.S. crew members before and after ISS missions. VESGEN analysis in previous research supported by the US National Institutes of Health identified surprising new opportunities to regenerate retinal vessels during early-stage, potentially reversible progression of the visually impairing and blinding disease, diabetic retinopathy.

  12. A Register-Based Study of Occupational Functioning in Non-Psychotic Patients Before and After Psychotherapy

    DEFF Research Database (Denmark)

    Fenger, Morten Munthe; Poulsen, Stig Bernt; Mortensen, Erik Lykke;

    2013-01-01

    higher number of days on sick leave (pcompared to the control group, while the change in days with unemployment was insignificant (p=0.501). Conclusion: Occupational outcome of psychotherapy may be less advantageous than shown in previous studies. Differences can...... perhaps be explained by the length and symmetry of the observation period before and after intervention. Other possible reasons for the outcome are: disorder chronicity; a labor market that excludes individuals with mental disorders; and that psychotherapy does not address occupational functioning....

  13. Sensation Seeking and Perceived Need for Structure Moderate Soldiers’ Well-Being Before and After Operational Deployment

    OpenAIRE

    Parmak, Merle; Mylle, Jacques J. C.; Martin C. Euwema

    2014-01-01

    This study examined associations between sensation seeking and perceived need for structure, and changes in reported well-being among deployed soldiers. Participants (n = 167) were assessed before and after a six-month deployment to south Afghanistan. Results indicated that although well-being declined in the soldier sample as a whole following deployment, the degree of decrease was significantly different among soldiers with different personality profiles. Differences were moderated by soldi...

  14. Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy

    OpenAIRE

    Kasimir-Bauer, Sabine; BITTNER, ANN-KATHRIN; König, Lisa; Reiter, Katharina; Keller, Thomas; Kimmig, Rainer; HOFFMANN, OLIVER

    2016-01-01

    Background Patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NACT) may experience metastatic relapse despite achieving a pathologic complete response. We analyzed patients with BC before and after NACT for disseminated tumor cells (DTCs) in the bone marrow(BM); comprehensively characterized circulating tumor cells (CTCs), including stem cell–like CTCs (slCTCs), in blood to prove the effectiveness of treatment on these cells; and correlated these findings with response to t...

  15. Comparing Cystatin C Changes as a Measure of Renal Function Before and After Radiotherapy in Patients with Stomach Cancer

    OpenAIRE

    Ahmad Ameri; Asadollah Alidoosti; Khosro Mojir Sheybani; Farnaz Taslimi; Morteza Tabatabaiefar; Maryam Mirzaie Moghadam; Hooshang Amir Rasouli; Pedram Fadavi; Shahrzad Aref

    2012-01-01

    The objective of this study was to determine and compare Cystatin C changes before and after radiotherapy in patients with stomach cancer who were candidate for radiotherapy. This study was conducted as a prospective cohort one. Eighteen patients with definite diagnosis of stomach cancer under treatment by radiotherapy who presented to Radiotherapy-Oncology Center of Imam Hossein Hospital, Tehran-Iran, and the treatment in all cases was simultaneous chemoradiation with Xeloda were included. I...

  16. Effects of Oxygen on Exercise Duration in Chronic Obstructive Pulmonary Disease Patients before and after Pulmonary Rehabilitation

    OpenAIRE

    Nha Voduc; Caroline Tessier; Elham Sabri; Dean Fergusson; Lyne Lavallee; Aaron, Shawn D.

    2010-01-01

    BACKGROUND: Supplemental oxygen therapy has been shown to improve exercise performance in patients with chronic obstructive pulmonary disease (COPD). It is unknown whether the magnitude of this benefit would be affected by participation in a pulmonary rehabilitation program.OBJECTIVE: To compare the effects of supplemental oxygen on exercise capacity in nonhypoxemic COPD patients before and after participation in a pulmonary rehabilitation program.METHODS: Sixteen patients with COPD underwent...

  17. Does Marriage Lead to Specialization? An Evaluation of Swedish Trends in Adult Earnings Before and After Marriage

    OpenAIRE

    Sundström, Marianne; Ginther, Donna K.

    2010-01-01

    We examine whether marriage leads to specialization in Sweden by implementing a model that differentiates specialization in the household by cohabitation and marriage. Our paper evaluates this model using panel data to analyze trends in earnings before and after marriage between 1985 and 1995 for married and long-term cohabiting Swedish couples with children. To identify the effect of marriage on earnings we use the reform of the widow’s pension system that resulted in a marriage boom in Swed...

  18. Prevalence of lipid abnormalities before and after introduction of lipid modifying therapy among Swedish patients with dyslipidemia (PRIMULA)

    OpenAIRE

    Martinell Mats; Sazonov Vasilisa; Ambegaonkar Baishali; Pettersson Billie; Stålhammar Jan; Wändell Per

    2010-01-01

    Background: Data on the prevalence of dyslipidemia and attainment of goal/normal lipid levels in a Swedish population are scarce. The objective of this study is to estimate the prevalence of dyslipidemia and attainment of goal/normal lipid levels in patients treated with lipid modifying therapy (LMT). Methods: This longitudinal retrospective observational study covers time periods before and after treatment. Data were collected from 1994-2007 electronic patient records in public primary healt...

  19. Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: a prospective cohort studya prospective cohort study

    OpenAIRE

    Kubo, Kimitoshi; Kawakami, Hiroshi; Kuwatani, Masaki; Nishida, Mutsumi; Kawakubo, Kazumichi; Kawahata, Shuhei; Taya, Yoko; Kubota, Yoshimasa; Amano, Toraji; Shirato, Hiroki; Sakamoto, Naoya

    2016-01-01

    Background Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elas...

  20. Values Following a Major Terrorist Incident: Finnish Adolescent and Student Values Before and After September 11, 2001

    OpenAIRE

    Goodwin, R; Verkasalo, M.; Bezmenova, I

    2006-01-01

    The horrific terrorist attacks on the United States on September 11, 2001, left an indelible mark on perceptions of security and threat across the world. This paper uses Schwartz’s (1992) value circumplex model to examine value change across matched high school and university student samples in Finland, questioned before and after the World Trade Center (WTC) and associated attacks. In Study 1 (N5419), security values of adolescents were higher the day following the WTC atta...

  1. Comparison of anti-mullerian hormone level in non-endometriotic benign ovarian cyst before and after laparoscopic cystectomy

    OpenAIRE

    Sedigheh Amooee; Mahboubeh Gharib; Parsa Ravanfar

    2015-01-01

    Background: Benign ovarian cysts are common among both pre- and postmenstrual women. Surgical intervention for excision of an ovarian cyst is mandated when symptomatic, or chance for malignancy is high. The damaging effect of surgical ovarian cystectomy on ovarian reserve is debated in recent studies. Objective: In the present study we investigated serum level of anti-mullerian hormone (AMH) as an indicator of ovarian reserve before and after surgical cystectomy. Materials and Methods: ...

  2. Influence of Weave on Fabric Wrinkle Recovery Property before and after Resin Treatment

    Institute of Scientific and Technical Information of China (English)

    马海青; 周翔

    2001-01-01

    Cotton fabrics with different weaves are designed and the influence of weave on wrinkle recovery property and tensile property is analyzed. Weave type plays a prominent part in determining fabric wrinkle recovery property and tensile property. Weave factor C is in direct relation to wrinkle recovery angle and in inverse relation to tensile property. This trend also exists after resin treatment. 3/1 left-twill fabric shows good wrinkle recovery angle and lest tensile loss after resin treatment.

  3. Stage of Change and Motivation to a Healthier Lifestyle before and after an Intensive Lifestyle Intervention

    OpenAIRE

    Buratta Livia; Reginato Elisa; Ranucci Claudia; Pippi Roberto; Aiello Cristina; Sbroma Tomaro Emilia; Perrone Chiara; Tirimagni Alberto; Russo Angelo; De Feo Pierpaolo; Mazzeschi Claudia

    2016-01-01

    Objective. Lifestyle modification programs are different but typically include both nutritional aspects and physical activity as main domains with different behavioral and/or psychological strategies designed to affect change. A fundamental role in modifying unhealthy habits is played by personal motivation for change. The present study sought to investigate, in a group of 100 overweight/obese outpatients with and/or without TMD2, treatment seeking, the effect of an intensive lifestyle progra...

  4. Reduced incidence of admissions for myocardial infarction associated with public smoking ban: before and after study

    OpenAIRE

    Sargent, R P; Shepard, R M; Glantz, Stanton A. Ph.D.

    2004-01-01

    Objective To determine whether there was a change in hospital admissions for acute myocardial infarction while a local law banning smoking in public and in workplaces was in effect. Design Analysis of admissions front December 1997 through November 2003 using Poisson analysis. Setting Helena, Montana, a geographical]), isolated community with one hospital serving a population of 68140. Participants All patients admitted for acute myocardial infarction. Main outcome measures Number of monthly ...

  5. Relative shrinkage of adipocytes by paraffin in proportion to plastic embedding in human adipose tissue before and after weight loss.

    Science.gov (United States)

    Verhoef, Sanne P M; van Dijk, Paul; Westerterp, Klaas R

    2013-01-01

    Adipocyte size is a major modulator of endocrine functioning of adipose tissue and methods allowing accurate determination of adipocyte size are important to study energy metabolism. The aim of this study was to assess the relative shrinkage of adipocytes before and after weight loss by comparing adipose tissue from the same subjects embedded in paraffin and plastic. 18 healthy subjects (5 males and 13 females) aged 20-50 y with a BMI of 28-38 kg/m² followed a very low energy diet for 8 weeks. Adipose tissue biopsies were taken prior to and after weight loss and were processed for paraffin and plastic sections. Parameters of adipocyte size were determined with computer image analysis. Mean adipocyte size was smaller in paraffin compared to plastic embedded tissue both before (66 ± 4 vs. 103 ± 5 μm, P paraffin embedded tissue in proportion to plastic embedded tissue was not significantly different before and after weight loss (73 and 69%, respectively). Shrinkage due to the type of embedding of the adipose tissue can be ignored when comparing before and after weight loss. Plastic embedding of adipose tissue provides more accurate and sensitive results.

  6. Time-Based Network Analysis Before and After the M_w 8.3 Illapel Earthquake 2015 Chile

    Science.gov (United States)

    Pastén, Denisse; Torres, Felipe; Toledo, Benjamín; Muñoz, Víctor; Rogan, José; Valdivia, Juan Alejandro

    2016-06-01

    A complex network analysis of the seismic activity in the central zone of Chile is made, where each node corresponds to a location, where a seism occurs. The M_w = 8.3 Illapel earthquake (16 September 2015) is included in the data set studied. Assuming a self-similar data network, the value of the power law characteristic exponent γ for the link probability distribution of the directed network and the value of the power law characteristic exponent δ for the cumulative distribution of the betweenness centrality are studied, before and after the earthquake. Both exponents have a different values before and after the earthquake when the network is built with cell size of 5 × 5 × 5 km, but there is no difference when the cell size is 10 × 10 × 10 km. The exponents were evaluated for the data set with the total number of seismic events and for three cutoffs in magnitude. There is not much variation when applying the cutoff. Variations of both exponents are found when both subsets, before and after the main event, are compared, suggesting that the topological features of the complex network of seisms are modified by major events.

  7. The study of KBP of road construction workers of highway AIDS prevention project before and after intervention

    Institute of Scientific and Technical Information of China (English)

    Dan Liu; Si-Ping Dong; Guang-Ming Gao; Ming-Yu Fan; Zong-Jiu Zhang; Peng-Qian Fang

    2013-01-01

    Objective:To get scientific basis for further health education through the research of the road construction workers’KBP before and after the interventions of highwayAIDS prevention project. Methods:Multi-stage random sampling method was employeed to select workers of8 sites from14 sites along highway to investigate theirAIDS knowledge, belief and performance(KBP) before and after highwayAIDS prevention project.Results:Over90% of the investigated workers had ever heard aboutAIDS, and the non-skilled workers of lower educational level improved more after intervention.The correct answer rate of the three transmitting ways ofAIDS of drivers which is the focused group of highway before and after intervention had the obvious statistical significance(P<0.05), and the other group’s correct answer rates also had improved after intervention.Most people’s understanding of preventingAIDS through correct use of condoms when having sex had a statistically significant difference(P<0.05) after prevention.The rates of using condoms of foremen and skilled workers when having sex with commercial sex worker/casual partner increased after intervention.Conclusions:The health education ofHIV among the road construction workers is effective and further health education ofHIV prevention should be carried out among the road construction workers to improve their knowledge and awareness of avoiding the high-risk behaviors.

  8. CT perfusion assessment of Moyamoya syndrome before and after direct revascularization (superficial temporal artery to middle cerebral artery bypass)

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yueqin [Hospital of Qingdao University, Department of Radiology, Qingdao (China); Hospital of Jining Medical College, CT Department, Jining (China); Xu, Wenjian [Hospital of Qingdao University, Department of Radiology, Qingdao (China); Guo, Xiang; Shi, Zhitao; Sun, Zhanguo; Wang, Jiehuan [Hospital of Jining Medical College, CT Department, Jining (China); Gao, Lingyun [Hospital of Jining Medical College, MR Department, Jining (China); Jin, Feng [Hospital of Jining Medical College, Department of Neurosurgery, Jining (China); Chen, Weijian; Yang, Yunjun [Hospital of Wenzhou Medical University, Department of Radiology, Wenzhou (China)

    2016-01-15

    To evaluate the utility of CT perfusion (CTP) for the assessment of superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis in patients with Moyamoya syndrome (MMS). Twenty-four consecutive MMS patients, who underwent unilateral STA-MCA bypass surgery, received CTP before and after surgery. The relative perfusion parameter values of surgical hemispheres before treatment were compared with post-treatment values. All patients underwent CT angiography (CTA) before and after surgery in order to confirm the patency of bypass. The follow-up CTA after surgery clearly demonstrated 20 (20/24, 83.3 %) bypass arteries, whereas four (16.7 %) bypass arteries were occluded or very small. Postoperative rMTT and rTTP values (P < 0.05) of the surgical side were significantly lower than pre-operation. In patients (n = 20) with bypass patency, postoperative rCBF, rMTT and rTTP values (P < 0.05) of the surgical side were significantly improved. However, the differences of all parameters were not significant (P > 0.05) in the patients (n = 4) without bypass patency after revascularization. This study demonstrates that CTP can provide a crucial quantitative assessment of cerebral haemodynamic changes in MMS before and after STA-MCA anastomosis. (orig.)

  9. Quality of life in patients with primary axillary hyperhidrosis before and after treatment with fractionated microneedle radiofrequency

    Directory of Open Access Journals (Sweden)

    Bahareh Abtahi-Naeini

    2015-01-01

    Full Text Available Background: Primary axillary hyperhidrosis (PAH is a common condition with a great impact on the patient′s quality of life (QOL. It is associated with serious social, emotional, and occupational distress. The aim of this study was to investigate the QOL in patients with PAH before and after treatment with fractionated microneedle radiofrequency (FMR. Materials and Methods: We evaluated 25 patients with severe PAH. Each patient had three sessions of FMR treatment using a novel applicator at 3-week intervals. The study was based on Dermatology Life Quality Index (DLQI Questionnaires. Patients were evaluated at baseline and 3 months after the last session. Results: Our patients included 32% males and 68% females. The mean ± standard deviation (SD age of subjects was 30.2 ± 6.27 years. The mean ± SD of the DLQI before and after treatment was 12.96 ± 5.93, and 4.29 ± 2.21, respectively. There was a statistically significant difference between the before and after intervention (P < 0.001. No major, permanent adverse effects were shown. Conclusion: Treatment with FMR can improve the DLQI of patients with PAH.

  10. Ivy signs on FLAIR images before and after STA-MCA anastomosis in patients with Moyamoya disease

    Energy Technology Data Exchange (ETDEWEB)

    Ideguchi, Reiko; Enokizono, Mikako; Uetani, Masataka (Dept. of Radiological Sciences, Nagasaki Univ. Graduate School of Biomedical Sciences, Nagasaki (Japan)), e-mail: qqtt37gd9@forest.ocn.ne.jp; Morikawa, Minoru (Dept. of Radiology, Nagasaki Univ. School of Medicine, Nagasaki (Japan)); Ogawa, Yoji (Dept. of Radiology, Hanwa Daini Senboku Hospital, Osaka (Japan)); Nagata, Izumi (Dept. of Neurosurgery, Nagasaki Univ. School of Medicine, Nagasaki (Japan))

    2011-04-15

    Background: Leptomeningeal high signal intensity (ivy sign) on fluid-attenuated inversion-recovery (FLAIR) MR imaging is one of the features of Moyamoya disease. However, the correlation between ivy sign and cerebral perfusion status has not been fully evaluated. Purpose: To characterize ivy sign on FLAIR images in Moyamoya disease and compare this finding with hemodynamic alterations on perfusion single-photon emission CT (SPECT) obtained before and after bypass surgery. Material and Methods: Sixteen patients with angiographically confirmed Moyamoya disease who underwent superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis were included in the study. The presence of ivy sign on FLAIR images was classified as 'negative', 'minimal' and 'positive'. We evaluated the relationship between ivy sign and findings of SPECT, including cerebral vascular reserve (CVR) before and after surgery. Results: Minimal or positive ivy sign was seen in 13 (81%) of 16 patients, and 21 (66%) of 32 hemispheres. CVR in the areas with positive or minimal ivy sign was lower than that in the areas with negative ivy sign. After STA-MCA anastomosis, ivy sign disappeared or decreased in all 21 hemispheres demonstrating ivy sign. SPECT demonstrated apparent hemodynamic improvement in areas demonstrating disappearance or decrease of ivy sign. Conclusion: Ivy sign on FLAIR image is seen in areas with decreased cerebral perfusion. The sign is useful for non-invasive assessment of cerebral hemodynamic status before and after surgery

  11. Microbial water quality before and after the repair of a failing onsite wastewater treatment system adjacent to coastal waters

    Science.gov (United States)

    Conn, K.E.; Habteselassie, M.Y.; Denene, Blackwood A.; Noble, R.T.

    2012-01-01

    Aims: The objective was to assess the impacts of repairing a failing onsite wastewater treatment system (OWTS, i.e., septic system) as related to coastal microbial water quality. Methods and Results: Wastewater, groundwater and surface water were monitored for environmental parameters, faecal indicator bacteria (total coliforms, Escherichia coli, enterococci) and the viral tracer MS2 before and after repairing a failing OWTS. MS2 results using plaque enumeration and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) often agreed, but inhibition limited the qRT-PCR assay sensitivity. Prerepair, MS2 persisted in groundwater and was detected in the nearby creek; postrepair, it was not detected. In groundwater, total coliform concentrations were lower and E.??coli was not detected, while enterococci concentrations were similar to prerepair levels. E.??coli and enterococci surface water concentrations were elevated both before and after the repair. Conclusions: Repairing the failing OWTS improved groundwater microbial water quality, although persistence of bacteria in surface water suggests that the OWTS was not the singular faecal contributor to adjacent coastal waters. A suite of tracers is needed to fully assess OWTS performance in treating microbial contaminants and related impacts on receiving waters. Molecular methods like qRT-PCR have potential but require optimization. Significance and Impact of Study: This is the first before and after study of a failing OWTS and provides guidance on selection of microbial tracers and methods. ?? 2011 The Authors. Journal of Applied Microbiology ?? 2011 The Society for Applied Microbiology.

  12. Validity of resting energy expenditure predictive equations before and after an energy-restricted diet intervention in obese women.

    Directory of Open Access Journals (Sweden)

    Jonatan R Ruiz

    Full Text Available BACKGROUND: We investigated the validity of REE predictive equations before and after 12-week energy-restricted diet intervention in Spanish obese (30 kg/m(2>BMI<40 kg/m(2 women. METHODS: We measured REE (indirect calorimetry, body weight, height, and fat mass (FM and fat free mass (FFM, dual X-ray absorptiometry in 86 obese Caucasian premenopausal women aged 36.7±7.2 y, before and after (n = 78 women the intervention. We investigated the accuracy of ten REE predictive equations using weight, height, age, FFM and FM. RESULTS: At baseline, the most accurate equation was the Mifflin et al. (Am J Clin Nutr 1990; 51: 241-247 when using weight (bias:-0.2%, P = 0.982, 74% of accurate predictions. This level of accuracy was not reached after the diet intervention (24% accurate prediction. After the intervention, the lowest bias was found with the Owen et al. (Am J Clin Nutr 1986; 44: 1-19 equation when using weight (bias:-1.7%, P = 0.044, 81% accurate prediction, yet it provided 53% accurate predictions at baseline. CONCLUSIONS: There is a wide variation in the accuracy of REE predictive equations before and after weight loss in non-morbid obese women. The results acquire especial relevance in the context of the challenging weight regain phenomenon for the overweight/obese population.

  13. Seismic reflection surveys before and after BEXAR at the Nevada Test Site

    International Nuclear Information System (INIS)

    It is believed that spall may have an important effect on various DOE systems designed for verification of -nuclear underground test treaties. The acoustic pulse studied by the Ionospheric Monitoring Program is created specifically by the rapid acceleration of the ground surface of the spall region. Simulation studies indicated that spall effects on surface and body waves may need to be included for proper regional discrimination and yield estimation (Taylor and Randall, 1989). Detailed experimental studies of spall have been sparse. Some work with small contained chemical explosions (Stump, 1985) have measured the spall mass and characteristics. There is a need to extend these measurements to full UGT strengths

  14. Student Performance in a Pharmacotherapy Oncology Module Before and After Flipping the Classroom.

    Science.gov (United States)

    Bossaer, John B; Panus, Peter; Stewart, David W; Hagemeier, Nick E; George, Joshua

    2016-03-25

    Objective. To determine if a flipped classroom improved student examination performance in a pharmacotherapy oncology module. Design. Third-year pharmacy students in 2012 experienced the oncology module as interactive lectures with optional case studies as supplemental homework. In 2013, students experienced the same content in a primarily flipped classroom. Students were instructed to watch vodcasts (video podcasts) before in-class case studies but were not held accountable (ie, quizzed) for preclass preparation. Examination questions were identical in both cohorts. Performance on examination questions was compared between the two cohorts using analysis of covariance (ANCOVA), with prior academic performance variables (grade point average [GPA]) as covariates. Assessment. The students who experienced the flipped classroom approach performed poorer on examination questions than the cohort who experienced interactive lecture, with previous GPA used as a covariate. Conclusion. A flipped classroom does not necessarily improve student performance. Further research is needed to determine optimal classroom flipping techniques. PMID:27073284

  15. Student Performance in a Pharmacotherapy Oncology Module Before and After Flipping the Classroom.

    Science.gov (United States)

    Bossaer, John B; Panus, Peter; Stewart, David W; Hagemeier, Nick E; George, Joshua

    2016-03-25

    Objective. To determine if a flipped classroom improved student examination performance in a pharmacotherapy oncology module. Design. Third-year pharmacy students in 2012 experienced the oncology module as interactive lectures with optional case studies as supplemental homework. In 2013, students experienced the same content in a primarily flipped classroom. Students were instructed to watch vodcasts (video podcasts) before in-class case studies but were not held accountable (ie, quizzed) for preclass preparation. Examination questions were identical in both cohorts. Performance on examination questions was compared between the two cohorts using analysis of covariance (ANCOVA), with prior academic performance variables (grade point average [GPA]) as covariates. Assessment. The students who experienced the flipped classroom approach performed poorer on examination questions than the cohort who experienced interactive lecture, with previous GPA used as a covariate. Conclusion. A flipped classroom does not necessarily improve student performance. Further research is needed to determine optimal classroom flipping techniques.

  16. Clinical and urodynamic evaluation of women with detrusor instability before and after functional pelvic floor electrostimulation.

    Science.gov (United States)

    Arruda, R M; Castro, R A; Sartori, M G F; Takano, C C; Baracat, E C; Rodrigues de Lima, G; Girão, M J B C

    2003-01-01

    Detrusor instability is the second most frequent cause of female urinary incontinence. There are many therapeutic options, including non-invasive and surgical procedures. In this study, we evaluated the effects of pelvic floor vaginal electrostimulation using equipment designed in our institution, over three consecutive months, for treatment of 29 women with detrusor instability. After treatment 22 patients (76%) considered themselves cured or symptomatically improved; seven patients (24%) had no change in symptoms after therapy. There was objective cure and improvement in ten (34.5%) and in eight (27.5%) patients, respectively, and the urodynamic parameters did not change in 11 patients (38%). Electrical stimulation resulted in a gradual decrease in the number of urinary leakage episodes and increase in maximum cystometric capacity in first desire to void and in urinary volume.

  17. Microstructure of AE44 magnesium alloy before and after hot-chamber die casting

    Directory of Open Access Journals (Sweden)

    A. Kiełbus

    2007-01-01

    Full Text Available Purpose: AE44 magnesium alloy allows attractive high temperature mechanical properties, as well as diecastabilityand good corrosion resistance. It contains magnesium, aluminum, cerium and lanthanum. Typically,it is used in automotive industry for structural components working at elevated temperature (150÷175°C. Theaim of this paper is to present the results of investigations on the microstructure of the AE44 magnesium alloybefore and after hot chamber die casting.Design/methodology/approach: Die casting was carried out on 280 tone locking force hot-chamber die castingmachine. For the microstructure observation, a Olympus GX+70 metallographic microscope and a HITACHIS-3400N scanning electron microscope with a Thermo Noran EDS spectrometer equipped with SYSTEM SIXwere used.Findings: Based on the investigation carried out it was found that the AE44 magnesium alloy before diecasting is characterized by α-Mg solid solution with globular, lamellar and acicular precipitations of Al11RE3and Al3RE phases. Moreover, there was found globular Mn-rich phase existence (probably Al8CeMn4 phase.After hot-chamber die casting the microstructure of AE44 alloys consist of equiaxed dendrites of α-Mg withprecipitates of Al11RE3 and probably Al2RE phase.Research limitations/implications: Future researches should contain investigations of the influence of the hotchamber die casting process parameters on the microstructure and mechanical properties of AE44 magnesiumalloy.Practical implications: AE44 magnesium alloy can be cast with cold- and hot-chamber die casting machine.Results of investigation may be useful for preparing die casting technology of this alloy.Originality/value: The results of the researches make up a basis for the investigations of new magnesium alloyscontaining rare earth elements for hot chamber die casting designed to service in elevated temperature.

  18. Performance evaluation before and after solar seasonal storage coupled with ground source heat pump

    International Nuclear Information System (INIS)

    Highlights: • A solar seasonal storage coupled with ground source heat pump system was designed and implemented. • The COP of GSHP system and coupled system were calculated and compared. • The COP of the coupled system was higher than that of GSHP system. • The soil temperature increased after solar seasonal storage process. - Abstract: The COP (Coefficient of Performance) of the ground-source heat pump (GSHP) system decreased gradually year after year mainly caused by imbalance of thermal energy inputting, especially in heating-dominated climate zones. An experimental system of solar seasonal storage coupling with ground-source heat pump was designed and implemented. This system was installed in a group of new buildings of the new campus in Tianjin, China, which is located in cold climate zone and heat demand is dominated. To make evaluation to this system, a mathematical method was developed to calculate the COP of GSHP system and the coupled system. In this thermal storage experiment process, a system with 1500 m2 solar thermal collectors and 580 sets of 120 m deep ground thermal exchangers was involved in this research. Results show that the soil temperature has not descended but increased by 0.21 °C, and the COP of system and heat pump unit increased 3.4% and 2.4% respectively compared to the operation data without solar seasonal storage process during last year. Although the effectiveness of solar seasonal storage coupled is not conspicuous as expected during the testing period, it indicates that the tendency of COP declination is prevented, and further illustrating that improving the COP of the system is a long-term work, the application of solar seasonal storage coupled with GSHP system should be encouraged for long-term operation

  19. Self-Reported Psychosocial Health in Obese Patients before and after Weight Loss

    Directory of Open Access Journals (Sweden)

    G. Osei-Assibey

    2010-01-01

    Full Text Available Psychosocial profiles were examined in 255 morbidly obese patients attending a hospital service offering access to standard weight loss therapies. 129 patients were reassessed after at least 6-month follow-up. At baseline, 51.8% and 32.7% of patients, respectively, had evidence of anxiety and depressive disorders, 24% had severe impairments in self esteem, and 29.7% had an increased risk of eating disorders. At follow-up, weight loss from baseline was significant in all 3 therapies: diet only is 0.74±1.8 kg; pharmacotherapy is 6.7±4.2 kg; and surgery is 20.1±13.6 kg. Anxiety scores improved in all three groups (<.05. Patients having pharmacotherapy or surgery had significant improvements in physical and work function and public distress compared to those having dietary treatment only (<.05. Our observational data suggest that weight management services can lead to psychosocial benefit in morbidly obese patients. Well-designed studies are necessary to examine the link between weight loss and emotional health.

  20. Background Noise Distribution before and afterHigh-Resolution Processing in Ship-borne Radar

    Institute of Scientific and Technical Information of China (English)

    ZHANGZhong

    2005-01-01

    When high-resolution algorithm is applied in ship-borne radar~ high-resolution algorithm's nonlinearity and distributional characteristics before highresolution processing determine background clutter's distributional characteristics after high-resolution and detector design afterwards. Because background noise before high-resolution has physical significance, the statistical model of first-order Bragg lines and second order components of sea clutter is put forward. Then by using higher-order cumulative quantity's statistical verification of actually measured data, it is concluded that background noise before high-resolution conforms to normal distribution in ship-borne radar. The non-linearity of high-resolution algorithm determines that background noise after high-resolution processing conforms to non-normal distribution. Non-normal distributed clutter mainly include Weibull, Lognormal and K clutter. Rayleigh clutter can be seen as special case of Weibull clutter. These clutter have differently statistical characteristics and can be discriminated by clutter characteristics recognition. The numerical domain's distribution after high-resolution processing is determined by improved minimum entropy clutter characteristics recognition method based on rule AIC, namely two-parameter domain scanning method. This identification method has higher recognition rate. It is verified that background noise after high-resolution by pre-whitenedMUSIC conforms to lognormal distribution.

  1. From research to the construction of repository - Development before and after construction license

    International Nuclear Information System (INIS)

    The disposal of spent nuclear fuel from the Finnish nuclear power plants will be implemented by Posiva Oy, a company jointly owned by the two nuclear power companies Fortum Oyj and Teollisuuden Voima Oy. Posiva Oy coordinates, manages and prepares the research, development and construction activities within time frames set already in beginning of 1980 by The Finnish Government. After extensive site investigations the Olkiluoto site in Eurajoki municipality was selected for further investigations in spring 2001. To construct a KBS-3 type repository at the depth of 400-500 metres of crystalline bedrock the construction license application will be submitted in 2012. After the construction licence, the next major milestone is the operating licence, scheduled for 2020. The operational phase will be rather long. Taking into account the current plans for the operation of the nuclear power plants, the disposal facility will be closed sometime in the 2100's. In preparation for the construction licence Posiva is constructing the underground rock characterisation facility ONKALO. It aims to confirm the results from site investigations, allows practicing the underground characterisation and construction methods during the construction. It also serves as an opportunity to develop quality management practices and investigate, test and demonstrate the functioning of the engineered barrier system. When ONKALO will reach the target depth 420 meters it also helps to design the repository layout and characterise the repository panels further in detail. ONKALO will also be part of the repository serving as an access to the repository. ONKALO access tunnel has been excavated with the conventional drill and blast method with inclination 1:10, which means that the length of the access tunnel will be approximately 5 km.. Concurrently with the tunnel excavation three raise bored vertical shafts are under construction for taking care the ventilation and personnel access to the ONKALO. The

  2. Comparing environmental issues in Cuba before and after the Special Period: balancing sustainable development and survival.

    Science.gov (United States)

    Maal-Bared, Rasha

    2006-04-01

    Following the Earth Summit in 1992, Cuba designed and implemented a variety of programs, administrative structures, and public awareness activities to promote sound environmental management and sustainable development. This came shortly after the fall of the Soviet Union and the strengthening of the US blockade in 1990, which resulted in a 35% drop in Cuban GDP. This period, referred to as the Special Period, witnessed a decrease in many environmentally damaging activities both by choice and by necessity, but also resulted in many decisions to resuscitate the Cuban economy. The purpose of this work was to compare and rank the environmental risks Cuba faced before and during the Special Period (1990-2000) using two Comparative environmental risk assessments (CERAs). To do so, an ecosystem integrity risk assessment matrix was constructed with 42 risk end points. The matrix assessed the risk posed by 17 problem areas including air pollution, water contamination, solid waste sites, pesticides and ecosystem degradation. The risks were calculated using five criteria: area affected, vulnerability of affected population, severity of impact, irreversibility of effect and uncertainty. To construct this matrix, both literature reviews and expert interviews in Cuba were conducted in 2000. The results showed a general decrease in risk scores during the Special Period. Before the Special Period, high risks were posed by: terrestrial degradation and industrial wastewater and sludge, followed by freshwater degradation, surface water stressors, and pesticides. After the Special Period, industrial wastewater and sludge and pesticides were no longer high-risk areas, but municipal wastewater and marine coastal degradation ranked higher than previously. Also, the risk endpoints most stressed after 1990 were affected by activities controlled by the government, such as mining and tourism, and lack of infrastructure. Therefore, the claims that public environmental education is the main

  3. Complying with the smoking ban by students before and after introducing legislative intervention

    Directory of Open Access Journals (Sweden)

    Adam Rzeźnicki

    2015-04-01

    Full Text Available Objectives: More and more countries introduce a total ban on smoking tobacco in public places. The aim of this work was to evaluate the effectiveness of “The Act of 8 April 2010 on amendment of the act on protection of health against the consequences of consumption of tobacco and tobacco products and act on National Sanitary Inspectorate” and assess the frequency of complying with the smoking bans by the students of the Medical University of Lodz, Poland. Material and Methods: Between 2007–2011, at the Social Medicine Institute of the Medical University of Lodz, a study using random survey was carried out involving students who were starting their studies at the Health Department of the Medical University of Lodz. The analysis of the collected material showed that 1038 people reported being smokers at the time of the study. Among that group, 530 students were included in the study prior to, and 508 after the introduction of the amendment. In order to verify their compliance with the smoking ban, the respondents were asked whether they smoked only in designated areas or wherever they wanted to. Results: The ratio of people claiming they smoked anywhere they wanted to, disregarding the smoking ban, was 60% (N = 318 and after the amendment had been introduced, this ratio was 62.2% (N = 316, it increased by 2.2 percentage points. The observed difference was statistically irrelevant (Chi2 = 0.530, p > 0.05. Conclusions: The Act ”On amendment of the act on protection of health against the consequences of consumption of tobacco and tobacco products and Act on National Sanitary Inspectorate” in Poland did not result in the expected changes in the frequency of complying with the smoking ban by the 1st year students.

  4. Earthquake engineering development before and after the March 4, 1977, Vrancea, Romania earthquake

    International Nuclear Information System (INIS)

    At 25 years since the of the Vrancea earthquake of March, 4th 1977, we can analyze in an open and critical way its impact on the evolution of earthquake engineering codes and protection policies in Romania. The earthquake (MG-R = 7.2; Mw = 7.5), produced 1,570 casualties and more than 11,300 injured persons (90% of the victims in Bucharest), seismic losses were estimated at more then USD 2 billions. The 1977 earthquake represented a significant episode of XXth century in seismic zones of Romania and neighboring countries. The INCERC seismic record of March 4, 1977 put, for the first time, in evidence the spectral content of long period seismic motions of Vrancea earthquakes, the duration, the number of cycles and values of actual accelerations, with important effects of overloading upon flexible structures. The seismic coefficients ks, the spectral curve (the dynamic coefficient βr) and the seismic zonation map, the requirements in the antiseismic design norms were drastically, changed while the microzonation maps of the time ceased to be used, and the specific Vrancea earthquake recurrence was reconsidered based on hazard studies Thus, the paper emphasises: - the existing engineering knowledge, earthquake code and zoning maps requirements until 1977 as well as seismology and structural lessons since 1977; - recent aspects of implementing of the Earthquake Code P.100/1992 and harmonization with Eurocodes, in conjunction with the specific of urban and rural seismic risk and enforcing policies on strengthening of existing buildings; - a strategic view of disaster prevention, using earthquake scenarios and loss assessments, insurance, earthquake education and training; - the need of a closer transfer of knowledge between seismologists, engineers and officials in charge with disaster prevention public policies. (author)

  5. Characterization of silicon pixel detectors with the $n^{+} n/p^{+}$ and double-sided multiguard ring structure before and after neutron-irradiation

    CERN Document Server

    Cho Hyo Sung; Chien, C Y; Liang, G W; Huang, W; Dezillie, B; Eremin, V V; Li, Z

    2000-01-01

    The lifetime of silicon detectors in a severe radiation environment at CERN LHC depends strongly upon careful detector design and material selection, due to the anticipated radiation-induced damage. We fabricated recently more radiation-tolerant CMS forward pixel sensors with new designs of silicon pixel detectors with the n/sup + //n/p/sup +/ and double-sided multiguard ring structure. Electrical characterization of such devices was performed before and after irradiation to neutron fluences (1 MeV equivalent) up to 6*10/sup 14/ n/cm/sup 2/, measuring leakage current, potential distribution over the guard rings and full depletion voltage. Studies on the radiation hardness using oxygen-enriched silicon substrates are being presented separately. (7 refs).

  6. Characterization of silicon pixel detectors with the $n^{+}/n/p^{+}$ and double-sided multiguard ring structure before and after neutron irradiation

    CERN Document Server

    Cho Hyo Sung; Chien, C Y; Liang, G W; Huang, W; Dezillie, B; Eremin, V V; Li, Z

    2000-01-01

    The lifetime of silicon detectors in a severe radiation environment at CERN LHC depends strongly upon careful detector design and material selection, due to the anticipated radiation-induced damage. We fabricated recently more radiation-tolerant CMS forward pixel sensors with new designs of silicon pixel detectors with the n/sup + //n/p/sup +/ and double-sided multiguard ring structure. Electrical characterization of such devices was performed before and after irradiation to neutron fluences (1 MeV equivalent) up to 6*10/sup 14/ n/cm/sup 2/, measuring leakage current, potential distribution over the guard rings and full depletion voltage. Studies on the radiation hardness using oxygen-enriched silicon substrates are being presented separately. (7 refs).

  7. Dopamine transporter density assessed with [123]IPT SPECT before and after risperidone treatment in children with tourette's disorder

    International Nuclear Information System (INIS)

    Tourette's disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the dopamine transporter (DAT) densities between drug-naive children with TD and normal children, and investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using iodine-123 labelled N-(3-iodopropen-2-yl)-2β-carbomethoxy-3beta-(4-chlorophenyl)tropane ([123I]IPT) single photon emission computed tomography (SPECT). [123I]IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in nine drug-naive children with TD. Eleven normal children also underwent SPECT imaging 2 hours after an intravenous administration of [123I]IPT. Drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with risperidone in children with TD was found, although tic symptoms were significantly improved with risperidone. These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system

  8. Vascular endothelial growth factor before and after locoregional treatment and its relation to treatment response in hepatocelluar carcinoma patients

    Institute of Scientific and Technical Information of China (English)

    Heba Sedrak; Noaman El-Garem; Mervat Naguib; Heba El-Zawahry; Mohamed Esmat; Lila Rashed

    2015-01-01

    Objective: To evaluate vascular endothelial growth factor (VEGF) levels in hepatocel-lular carcinoma patients before and after transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) and its relation to treatment response. Methods: A total of 40 patients with unrespectable hepatocelluar carcinoma were assessed clinically. Twenty patients were suitable to be treated by TACE, while other 20 patients were treated with PEI. Serum VEGF levels were measured before and 1 month after each procedure by ELISA. Response was assessed after 1 month according to Union Internationale Contre le Cancer evaluation criteria based on change in tumor size as measured by ultrasound. Results: There was no significant difference between TACE and PEI groups with regard to age, sex, tumor size, response to local therapy, or VEGF and alpha-fetoprotein before and after therapy. VEGF levels after TACE were significantly higher than before TACE [(298.1 ± 123.6) pg/mL vs. (205.8 ± 307.3) pg/mL;P=0.001]. Also, VEGF levels were significantly higher after PEI than before PEI [(333.8 ± 365.6) pg/mL vs. (245.3 ± 301.8) pg/mL;P=0.000]. Non-responders of both groups had significantly high VEGF levels than responder's, both before [(985.0 ± 113.2) pg/mL vs. (117.1 ± 75.3) pg/mL;P Conclusions: Both TACE and PEI were associated with an increase in serum VEGF in hepatocelluar carcinoma patients. Higher levels of VEGF before and after therapy were found in non-responders, suggesting that VEGF is a useful marker in predicting treatment response.

  9. Sleep before and after learning promotes the consolidation of both neutral and emotional information regardless of REM presence.

    Science.gov (United States)

    Cellini, Nicola; Torre, Jacopo; Stegagno, Luciano; Sarlo, Michela

    2016-09-01

    Sleep may play a role in consolidating emotional memories. However, studies on the effects of REM sleep on negative vs. neutral memories have produced inconsistent evidence. Here, we assess the role of NREM and REM sleep before and after learning in promoting the consolidation of neutral and arousing pleasant and unpleasant memories. Forty-six (32 F) healthy university students were exposed to a set of pictures at 1:00PM (Session 1) and to an equivalent set at 4:45PM (Session 2). All the pictures in Session 1 and Session 2 were presented again, intermixed with new similar pictures at 5:15PM in a memory recognition task. Following Session 1, participants took a 90/120-min nap (NAP group), while 16 participants remained awake (WAKE group). Via polysomnographic recording, the NAP group was segregated into REM (N=14) and NoREM groups (N=16). Indices of memory consolidation for both stimuli presented before (discriminability of Session 1 pictures in Session 3) and after sleep (discriminability of Session 2 pictures in Session 3) were calculated. Memory consolidation for pictures presented both before and after the sleep period was higher in the NAP group as compared to the WAKE group, but no differential role of REM sleep emerged. A memory consolidation advantage was evident for neutral over pleasant (but not unpleasant) pictures. Taken together, these results indicate that a daytime nap (with or without REM sleep) facilitates consolidation of declarative memories presented before and after sleep irrespective of their valence. PMID:27321589

  10. Behavioral and Neurological Responses to Musical Features in Adolescent Cochlear Implant Users Before and After an Intensive Musical Training Program

    DEFF Research Database (Denmark)

    Petersen, Bjørn

    This study aimed to investigate perception and processing of musical features in prelingually deaf adolescent CI-users and examine whether this is influenced by music training. Eleven adolescent CI-users received intensive music training for two weeks. Before and after training they completed...... responses for timbre, intensity and rhythm but not for pitch. No effect of training was found in the MMN responses. The findings indicate that despite congenital deafness and late implantation, young CI users are able to discriminate details in music. Furthermore, the behavioral advances suggest that...

  11. Study on determination of stress level by seismic stress drops and the stress axis deflections before and after large earthquakes

    Institute of Scientific and Technical Information of China (English)

    WAN Yong-ge

    2006-01-01

    To obtain the stress level at the earthquake source, this paper sets forth the solution of the stress magnitude at the earthquake source by seismic stress drop and the stress axis deflections before and after large earthquakes. The pre-seismic and post-seismic stress direction can be statistically determined by a large collection of foreshock and aftershock focal mechanism data while the stress drop can be determined through the source fracture inversion from seismic wave data or crust deformation data. The paper attempts to make a fundamental contribution to seismic dynamics.

  12. Gambling Behavior and Lotto Participation in Iceland: A Comparison before and after the Economic Collapse in 2008

    OpenAIRE

    Gunnur H. Stefánsdóttir 1988

    2015-01-01

    Gambling is popular all over the world and the accessibility to gambling has become more convenient and widespread with the advent of the Internet. The main aim of this study was to examine gambling behavior on the Icelandic national lottery (Lottó 5/40), before and after the economic collapse in Iceland 2008. The purpose was also to examine the effects of the jackpot size on participants’ purchases. The current study used data from the Icelandic Lottery and Sports betting database. Participa...

  13. Assessment of hepatocellular carcinoma vascularity before and after transcatheter arterial chemoembolization by using first pass perfusion weighted MR imaging

    Institute of Scientific and Technical Information of China (English)

    Jun-Gong Zhao; Gan-Sheng Feng; Xiang-Quan Kong; Xin Li; Ming-Hua Li; Ying-Sheng Cheng

    2004-01-01

    AIM: To assess the vascularity of hepatocellular carcinoma (HCC)before and after transcatheter arterial chemoembolization (TACE) with the quantitative parameters obtained by first pass perfusion weighted MR imaging (FP-MRI).METHODS: Seventeen consecutive patients with one to three lesions in liver underwent FP-MRI before treatment.FP-MRI was also performed one, three, six, nine months,and one year after TACE. The baseline signal intensity (SO)of pre-TACE and one month after TACE was analyzed, the vascularity of HCC assessed by steepest slope of the signal intensity versus time curves (SS) was blindly correlated with their DSA feature and clinical outcome.RESULT: No significant difference was found on baseline signal intensity (SO) between pre-TACE and one month after TACE (F=0.309, P=0.583), The SS (mean, 32% per second) of lesion one month after TACE was lower than that of pre-TACE (mean, 69% per second), but with no statistical significance (F=3.067, P=0.092). When local recurrence occurred, the time intensity curves became steeper. The vascularity of HCC before and after TACE graded by SS closely correlated with that by DSA (K=0.453, P<0.05).CONCLUSION: FP-MRI is a useful criterion for selecting effective interventional treatment for patients with HCC in their initial treatment and during follow up.

  14. PET Study in a Patient with Spinocerebellar Degeneration before and after Long-Term Administration of Thyrotropin Releasing Hormone

    Directory of Open Access Journals (Sweden)

    H. Tanji

    1996-01-01

    Full Text Available We studied the chronic effect of thyrotropin releasing hormone (TRH in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG and positron emission tomography (PET. A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. CMRG1c was markedly decreased in the cerebellum and there was no significant difference before and after the treatment, i.e. mean CMRG1c values were 4.92 and 4.90 mg/100 g/min, and the ratios of the cerebellum versus the frontal cortex were 0.50 and 0.51, respectively. The degree of disequilibrium of her body examined with stabilography became better by the 19th day and further improved by the 26th day after the start of TRH treatment. Based on the present study we conclude that long-term administration of TRH did not improve CMRG1c in the cerebellum, but evidently improved the sway of gravity center by stabilography. We speculate that the chronic effect of TRH was not necessarily due to an improvement of cerebellar function, because TRH receptors are widely distributed throughout the central nervous system.

  15. Changes of biogeochemical activities before and after significant mud displacement at the Håkon Mosby Mud Volcano (HMMV)

    Science.gov (United States)

    Felden, J.; Wenzhöfer, F.; Yoerger, D.; Camilli, R.; German, C.; Olu, K.; Feseker, T.; de Beer, D.; Boetius, A.

    2012-04-01

    The Håkon Mosby Mud Volcano (72°N, 14° 43' E, 1250 m water depth) was studied for a period of a year by the Long-term Observatory On Mud-volcano Eruptions (LOOME) in 2009-2010, to investigate temporal variations of mud volcanism and consequences for biogeochemical processes. The HMMV is a highly active methane cold seep ecosystem characterized by high rates of methane efflux. It hosts different chemosynthetic communities such as thiotrophic bacterial mats and siboglinid tubeworm assemblages. This study focuses on changes in community composition and biogeochemical activity such as methane emission, total benthic oxygen uptake, microbial methane and sulfate consumption before and after a major mud displacement recorded by LOOME. The sensor-enabled long-term observations of the HMMV habitats were combined with short-term analyses before and after the displacement events by ROVs QUEST (MARUM) and GENESIS (University of Gent), the AUV Sentry (WHOI) equipped with a multibeam and subbottom profiler, CTD and photographic unit as well as with a mass spectrometer. We found shifts in the distribution patterns of chemosynthetic communities and also substantial changes in their activity, consistent with changes in temperature gradients. This study was sponsored by the EU-Projects HERMIONE "Hotspot Ecosystem Research and Man's Impact on European Seas", and ESONET "European Seas Observatory Network" (Demonstration Mission LOOME "Long term observations on mud volcano eruptions").

  16. Comparison of Static Balance on a Platform in Young Adults With Down Syndrome Before and After a Dance Program.

    Science.gov (United States)

    Gutiérrez-Vilahú, Lourdes; Massó-Ortigosa, Núria; Costa-Tutusaus, Lluís; Guerra-Balic, Miriam; Rey-Abella, Ferran

    2016-07-01

    The purpose of the study was to compare postural control in static standing in young adults with and without Down syndrome (DS), with eyes closed and eyes open, before and after an 18-wk dance-based training program. The study included 11 young people with DS age 20.5 (1.3) yr and 11 without DS age 20.2 (2.0) yr. All parameters were recorded before and after the training program. Parameters related to center of pressure (COP; closed and open eyes) were recorded from a platform with the participant in bipedal standing position during 30 s. The results suggest that young people with DS have worse COP control in both visual conditions (closed and open eyes) and are affected by visual information in a different way than their peers without DS. In the group of young adults with DS, the dance-based training program improved some parameters related to the use of visual input in controlling COP.

  17. Pathways into homelessness: recently homeless adults problems and service use before and after becoming homeless in Amsterdam

    Directory of Open Access Journals (Sweden)

    de Wit Matty A

    2009-01-01

    Full Text Available Abstract Background To improve homelessness prevention practice, we met with recently homeless adults, to explore their pathways into homelessness, problems and service use, before and after becoming homeless. Methods Recently homeless adults (last housing lost up to two years ago and legally staying in the Netherlands were sampled in the streets, day centres and overnight shelters in Amsterdam. In April and May 2004, students conducted interviews and collected data on demographics, self reported pathways into homelessness, social and medical problems, and service use, before and after becoming homeless. Results among 120 recently homeless adults, (male 88%, Dutch 50%, average age 38 years, mean duration of homelessness 23 weeks, the main reported pathways into homelessness were evictions 38%, relationship problems 35%, prison 6% and other reasons 22%. Compared to the relationship group, the eviction group was slightly older (average age 39.6 versus 35.5 years; p = 0.08, belonged more often to a migrant group (p = 0.025, and reported more living single (p Conclusion the recently homeless fit the overall profile of the homeless population in Amsterdam: single (Dutch men, around 40 years, with a mix of financial debts, addiction, mental and/or physical health problems. Contacts with services were fragmented and did not prevent homelessness. For homelessness prevention, systematic and outreach social medical care before and during homelessness should be provided.

  18. Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children.

    Science.gov (United States)

    Igic, Marija; Mihailovic, Dragan; Kesic, Ljiljana; Milasin, Jelena; Apostolovic, Mirjana; Kostadinovic, Ljiljana; Janjic, Olivera Trickovic

    2012-07-01

    Gingival epithelial cells are the first physical barrier against periodontal pathogenic microorganisms. Bacterial products may penetrate the epithelium and directly disturb its integrity. We investigated the clinical and cytomorphological status of the gingiva in children with gingivitis before and after low-level laser therapy. The study enrolled 130 children divided into three groups: group 1 comprised 50 children with chronic catarrhal gingivitis who received basic treatment, group 2 comprised 50 children with chronic catarrhal gingivitis who received low-level laser treatment in addition to basic treatment, and group 3 comprised 30 children with healthy gingiva as controls. Oral hygiene and the status of the gingiva were assessed using the appropriate indexes before and after treatment. Inflammation of the gingiva was monitored by cytomorphometric evaluation. Cytomorphometric analysis revealed a statistically significant difference (p gingivitis. Evaluation using clinical parameters showed that treatment of gingivitis with basic treatment was successful. Cytomorphometric analysis showed that after basic treatment the nuclei of the stratified squamous epithelial cells of the gingiva were reduced in size, although not to the size found in healthy gingiva. However, after adjuvant low-level laser therapy, the size of the nuclei of the stratified squamous epithelial cells in the gingiva matched the size of the nuclei in the cells in healthy gingiva.

  19. Differences in regional pulmonary pressure–impedance curves before and after lung injury assessed with a novel algorithm

    International Nuclear Information System (INIS)

    Global pressure–volume (PV) curves are an adjunct measure to describe lung characteristics in patients with acute respiratory distress syndrome (ARDS). There is convincing evidence that high peak inspiratory pressures (PIP) cause barotrauma, while optimized positive end-expiratory pressure (PEEP) helps avoid mechanical injury to the lungs by preventing repeated alveolar opening and closing. The optimal values of PIP and PEEP are deduced from the shape of the PV curve by the identification of so-called lower and upper inflection points. However, it has been demonstrated using electrical impedance tomography (EIT) that the inflection points vary across the lung. This study employs a simple curve-fitting technique to automatically define inflection points on both pressure–volume (PV) and pressure–impedance (PI) curves to asses the differences between global PV and regional PI estimates in animals before and after induced lung injury. The results demonstrate a clear increase in lower inflection point (LIP) along the gravitational axis both before and after lung injury. Moreover, it is clear from comparison of the local EIT-derived LIPs with those derived from global PV curves that a ventilation strategy based on the PV curve alone may leave dependent areas of the lung collapsed. EIT-based PI curve analysis may help choosing an optimal ventilation strategy

  20. Preceptors' reflections on their educational role before and after a preceptor preparation course: A prospective qualitative study.

    Science.gov (United States)

    Mårtensson, Gunilla; Löfmark, Anna; Mamhidir, Anna-Greta; Skytt, Bernice

    2016-07-01

    During clinical practice, preceptors play an important educational role in helping nursing students become secure and effective practitioners. For this educational role they need adequate preparation. The aim of the present prospective study was to describe preceptors' experiences of their educational role before and after attending a university preceptor preparation course. This 7.5-credit, Master's level course is offered on a part-time basis and covers one semester. The theoretical approach was self-directed and reflective learning. Twentyseven preceptors participated in group interviews before and after the course, and data were analyzed using qualitative content analysis. The findings revealed a shift in preceptors' perceptions. Their view of the educational role changed from being characterized by individual experiences and notions to being guided by personal and formal demands. Before the course, the lack of sufficient preconditions for preceptorship predominated, whereas after the course participants described ways of creating such preconditions. Before the course, the supervisory process was described as teaching, whereas after the course it was described as a learning process for students. Using reflective learning in a preceptor preparation course can develop and strengthen preceptors' view of their educational role and help them manage and create the preconditions for preceptorship. PMID:27428684

  1. Comparison of Static Balance on a Platform in Young Adults With Down Syndrome Before and After a Dance Program.

    Science.gov (United States)

    Gutiérrez-Vilahú, Lourdes; Massó-Ortigosa, Núria; Costa-Tutusaus, Lluís; Guerra-Balic, Miriam; Rey-Abella, Ferran

    2016-07-01

    The purpose of the study was to compare postural control in static standing in young adults with and without Down syndrome (DS), with eyes closed and eyes open, before and after an 18-wk dance-based training program. The study included 11 young people with DS age 20.5 (1.3) yr and 11 without DS age 20.2 (2.0) yr. All parameters were recorded before and after the training program. Parameters related to center of pressure (COP; closed and open eyes) were recorded from a platform with the participant in bipedal standing position during 30 s. The results suggest that young people with DS have worse COP control in both visual conditions (closed and open eyes) and are affected by visual information in a different way than their peers without DS. In the group of young adults with DS, the dance-based training program improved some parameters related to the use of visual input in controlling COP. PMID:27623608

  2. Color stability of the artificial iris button in an ocular prosthesis before and after acrylic resin polymerization.

    Science.gov (United States)

    Moreno, Amália; Goiato, Marcelo Coelho; Oliveira, Kamila Freitas; Iyda, Mariana Garib; Haddad, Marcela Filié; de Carvalho Dekon, Stefan Fiuza; dos Santos, Daniela Micheline

    2015-12-01

    This study investigated the effects of the ocular prosthesis fabrication technique and the paint on the color stability of the artificial iris button before and after polymerization of the colorless resin. Sixty samples simulating artificial eyes were made, including 30 samples with blue- and 30 samples with sepia-colored artificial irises. Ten samples were made by each of three techniques (i.e., conventional, prefabricated cap, and inverted painting) for each color. The color of the artificial iris button was measured through reflection spectrophotometry by the CIE L*a* b* system before and after polymerization of the prosthesis (colorless resin). Data were evaluated by analysis of variance (ANOVA) and the Tukey honestly significant different (HSD) tests (α=0.05). All of the samples exhibited color changes. Samples made by the prefabricated cap technique exhibited the highest color change values for both colors (Partificial irises (Partificial irises exhibited lower color change values than blue-colored artificial irises for both techniques (Partificial iris color for each color tone and the conventional technique and the painting technique inverted were considered clinically acceptable for sepia color.

  3. Latent growth curve analysis of fear during a speech task before and after treatment for social phobia.

    Science.gov (United States)

    Price, Matthew; Anderson, Page L

    2011-11-01

    Models of social phobia highlight the importance of anticipatory anxiety in the experience of fear during a social situation. Anticipatory anxiety has been shown to be highly correlated with performance anxiety for a variety of social situations. A few studies show that average ratings of anxiety during the anticipation and performance phases of a social situation decline following treatment. Evidence also suggests that the point of confrontation with the feared stimulus is the peak level of fear. No study to date has evaluated the pattern of anxious responding across the anticipation, confrontation, and performance phases before and after treatment, which is the focus of the current study. Socially phobic individuals (N = 51) completed a behavioral avoidance task before and after two types of manualized cognitive behavioral therapy, and gave ratings of fear during the anticipation and performance phases. Results from latent growth curve analysis were the same for the two treatments and suggested that before treatment, anxiety sharply increased during the anticipation phase, was highly elevated at the confrontation, and gradually increased during the performance phase. After treatment, anxiety increased during the anticipation phase, although at a much slower rate than at pretreatment, peaked at confrontation, and declined during the performance phase. The findings suggest that anticipatory experiences are critical to the experience of fear for public speaking and should be incorporated into exposures. PMID:21907972

  4. Proteomic changes between male and female worms of the polychaetous annelid Neanthes arenaceodentata before and after spawning.

    Directory of Open Access Journals (Sweden)

    Kondethimmanahalli H Chandramouli

    Full Text Available The Neanthesacuminata species complex (Polychaeta are cosmopolitan in distribution. Neanthesarenaceodentata, Southern California member of the N. acuminata complex, has been widely used as toxicological test animal in the marine environment. Method of reproduction is unique in this polychaete complex. Same sexes fight and opposite sexes lie side by side until egg laying. Females lose about 75% of their weight and die after laying eggs. The male, capable of reproducing up to nine times, fertilizes the eggs and incubates the embryos for 3-4 weeks. The objective of this study was to determine if there is any set of proteins that influences this unique pattern of reproduction. Gel-based two-dimensional electrophoresis (2-DE and gel-free quantitative proteomics methods were used to identify differential protein expression patterns before and after spawning in both male and female N. arenaceodentata. Males showed a higher degree of similarity in protein expression patterns but females showed large changes in phosphoproteme before and after spawning. There was a decrease (about 70% in the number of detected phosphoproteins in spent females. The proteins involved in muscular development, cell signaling, structure and integrity, and translation were differentially expressed. This study provides proteomic insights of the male and female worms that may serve as a foundation for better understanding of unusual reproductive patterns in polychaete worms.

  5. The Parkinsonian Gait Spatiotemporal Parameters Quantified by a Single Inertial Sensor before and after Automated Mechanical Peripheral Stimulation Treatment

    Directory of Open Access Journals (Sweden)

    Ana Kleiner

    2015-01-01

    Full Text Available This study aims to evaluate the change in gait spatiotemporal parameters in subjects with Parkinson’s disease (PD before and after Automated Mechanical Peripheral Stimulation (AMPS treatment. Thirty-five subjects with PD and 35 healthy age-matched subjects took part in this study. A dedicated medical device (Gondola was used to administer the AMPS. All patients with PD were treated in off levodopa phase and their gait performances were evaluated by an inertial measurement system before and after the intervention. The one-way ANOVA for repeated measures was performed to assess the differences between pre- and post-AMPS and the one-way ANOVA to assess the differences between PD patients and the control group. Spearman’s correlations assessed the associations between patients with PD clinical status (H&Y and the percentage of improvement of the gait variables after AMPS (α<0.05 for all tests. The PD group had an improvement of 14.85% in the stride length; 14.77% in the gait velocity; and 29.91% in the gait propulsion. The correlation results showed that the higher the H&Y classification, the higher the stride length percentage of improvement. The treatment based on AMPS intervention seems to induce a better performance in the gait pattern of PD patients, mainly in intermediate and advanced stages of the condition.

  6. [Study on antiplatelet and antithrombin activitives and effective components variation of Puhuang-Wulingzhi before and after compatibility].

    Science.gov (United States)

    Su, Shu-lan; Xue, Ping; Ouyang, Zhen; Zhou, Wei; Duan, Jin-ao

    2015-08-01

    The changes of bioactive constituents were analyzed for Puhuang-Wulingzhi before and after compatibility and the antiplatelet and antithrombin activitives were evaluated in order to elucidate the scientific and reasonable of Puhuang-Wulingzhi compatibility. UPLC-QTOF-MA-Markerlynx, principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis were used for data analysis and tracking changes of chemical composition during the decocting process. In vitro platelet aggregation induced by ADP, thrombin time(TT) and prothrombin time (PT) were investigated for Puhuang-Wulingzhi before and after compatibility. The results showed that significant differences were found between the mixed decoction and codecoction of Wulingzhi and Puhuang. Five compounds changed obviously were identified as typhaneoside, naringenin, isorhamnetin-3-O-ruinoside, quercetin-3-O-neohesperidoside, kaempferol-3-O-neohesperidoside. The codecoction, comparing with the single decoction, was more significant in antiplatelet aggregation and could prolong thrombin time. In the same crude drug dose, the thrombin time (TT) elongation were greater. These data could provide references for elucidation of bioactive components for this herb pair. PMID:26790290

  7. Transport and noise properties of Si nanowire channels with different lengths before and after gamma radiation treatment

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jing; Vitusevich, Svetlana; Pud, Sergii; Sydoruk, Viktor; Offenhäusser, Andreas [Peter Grünberg Institute, Forschungszentrum Jülich (Germany); Petrychuk, Mykhailo [Taras Shevchenko National University, Kiev (Ukraine); Danilchenko, Boris [Institute of Physics, NASU, Kiev (Ukraine)

    2013-12-04

    The transport properties of Si nanowire (NW) structures fabricated on the basis of silicon on insulator (SOI) wafers were studied using noise spectroscopy before and after treatment with small doses of gamma radiation. The total resistance obtained from the I-V characteristics of Si NW structures scaled perfectly with length. Normalized flicker noise demonstrated 1/L{sup 2} dependence, which is a characteristic of dominant noise contribution from near-contact regions. The behavior changed to 1/L dependence after a small dose (1×10{sup 4} Gy) of gamma radiation treatment. Comparison of the random telegraph signal (RTS) noise parameters in the samples with small lengths before and after the treatment revealed a decrease in RTS amplitude and a shift to a lower frequency range after gamma irradiation. These results confirmed that the main changes in the samples were related to strain relaxation near-contact regions. In addition, such treatment resulted in a considerable decrease in the scattering data of device parameters.

  8. Effects of gamma-irradiation before and after cooking on bacterial population and sensory quality of Dakgalbi

    International Nuclear Information System (INIS)

    The purpose of this study was to compare the effect of gamma irradiation on the total bacterial population and the sensory quality of Dakgalbi irradiated before and after cooking. Fresh chicken meat was cut into small pieces and used to prepare Dakgalbi. For the preparation of Dakgalbi cooked with gamma-irradiated chicken meat and sauce (IBC), raw chicken meat and Dakgalbi sauce were irradiated and then stir-fried. For the preparation of Dakgalbi irradiated after cooking with raw chicken meat and sauce (IAC), raw chicken meat and Dakgalbi sauce were first cooked and subsequently irradiated. Under the accelerated storage condition of 35 °C for 7 days, bacteria in IBC were below the detection limit (1 log CFU/g) on day 1 but were detected on day 2 and gradually increased hereafter. In IAC, on the other hand, bacteria were not detected at all. Evaluation of sensory quality also decreased on both samples. However, IAC showed a better trend. Our results indicate that IAC protocol was a more effective method for reducing bacterial growth in Dakgalbi. - Highlights: ► We compared the microbial safety and sensory property of Dakgalbi irradiated before and after cooking. ► Dakgalbi irradiated after cooking can be more effective processing method on microbial safety. ► Sensory property decreased on both Dakgalbis by irradiation-induced off-flavor. ► Dakgalbi irradiated after cooking showed a better tendency on the sensory evaluation.

  9. Changes of fundus blood flow state of patients with open-angle glaucoma before and after the treatment

    Institute of Scientific and Technical Information of China (English)

    Huai-Jie Huang; Mei-Min Niu; Yi Yang; Ke-Qin Li

    2016-01-01

    Objective:To To study and observe the change situation of fundus blood flow state of patients with open-angle glaucoma before and after the treatment.Methods:A total of 60 patients with open-angle glaucoma treated in our hospital from October 2013 to May 2015 were selected as the observation group, and 60 healthy persons with physical examination at the same period were the control group, then the RI, PI, PSV, EDV and VM levels of ocular artery, central retinal artery and posterior ciliary artery of observation group before the treatment and at 2th, 4th, 8th and 12th week after the treatment and control group were compared.Results:The RI and PI levels of ocular artery, central retinal artery and posterior ciliary artery of observation group before the treatment and at 2th, 4th and 8th week after the treatment were higher than those of control group, while the PSV, EDV and VM levels of ocular artery, central retinal artery and posterior ciliary artery were lower than those of control group. The detection results of observation group at different time after the treatment were better than those before the treatment, and there were significant differences (P0.05).Conclusions:The changes of fundus blood flow state of patients with open-angle glaucoma before and after the treatment are great, and the various artery blood flow presents continuous improvement.

  10. Persistent inelastic deformation in central Japan revealed by GPS observation before and after the Tohoku-oki earthquake

    Science.gov (United States)

    Meneses-Gutierrez, Angela; Sagiya, Takeshi

    2016-09-01

    We analyze strain rate distribution in central-northeastern Japan based on continuous GPS data before and after the occurrence of the Great Tohoku earthquake (Mw 9.0) on March 11th, 2011, focusing on the far-field response in the Niigata Kobe Tectonic Zone (NKTZ), an E-W contraction region along the Japan seacoast of central Japan. Wavelength decomposition of the strain rate on the E-W direction, calculated from GPS data, indicates that the long-wavelength pattern changed from preseismic E-W contraction to postseismic E-W extension, representing elastic response to plate interaction at the Japan Trench. However, the short wavelength patterns reveal a persistent localized contraction zone around northern NKTZ before and after the Tohoku-oki earthquake. The persistent localized deformation pattern can be reproduced by an aseismic slip on a fault cutting the lower crust and a part of the upper crust. These results demonstrate that an inelastic process plays an essential role in the deformation of the Japan island arc.

  11. Proteomic Changes between Male and Female Worms of the Polychaetous Annelid Neanthes arenaceodentata before and after Spawning

    KAUST Repository

    Chandramouli, Kondethimmanahalli

    2013-08-30

    The Neanthes acuminata species complex (Polychaeta) are cosmopolitan in distribution. Neanthes arenaceodentata, complex, has been widely used as toxicological test animal in the marine environment. Method of reproduction is unique in this polychaete complex. Same sexes fight and opposite sexes lie side by side until egg laying. Females lose about 75% of their weight and die after laying eggs. The male, capable of reproducing up to nine times, fertilizes the eggs and incubates the embryos for 3-4 weeks. The objective of this study was to determine if there is any set of proteins that influences this unique pattern of reproduction. Gel-based two-dimensional electrophoresis (2-DE) and gel-free quantitative proteomics methods were used to identify differential protein expression patterns before and after spawning in both male and female N. arenaceodentata. Males showed a higher degree of similarity in protein expression patterns but females showed large changes in phosphoproteme before and after spawning. There was a decrease (about 70%) in the number of detected phosphoproteins in spent females. The proteins involved in muscular development, cell signaling, structure and integrity, and translation were differentially expressed. This study provides proteomic insights of the male and female worms that may serve as a foundation for better understanding of unusual reproductive patterns in polychaete worms. © 2013 Chandramouli et al.

  12. Ultrasound evaluation of patients with carpal tunnel syndrome before and after endoscopic release of the transverse carpal ligament

    Energy Technology Data Exchange (ETDEWEB)

    Abicalaf, C.A. [Department of Radiology, University of Sao Paulo (Brazil)]. E-mail: abicalaf@uol.com.br; Barros, N. de [Department of Radiology, University of Sao Paulo (Brazil); Sernik, R.A. [Department of Radiology, University of Sao Paulo (Brazil); Pimentel, B.F. [Department of Orthopedic Surgery, University of Taubate, Sao Paulo (Brazil); Braga-Baiak, A. [Department of Radiology, University of Sao Paulo (Brazil); Braga, L. [Department of Radiology, University of Nebraska Medical Center (United States); Houvet, P. [Department of Radiology, Pitie Salpetriere Hospital, Paris (France); Brasseur, J.-L. [Department of Radiology, Pitie Salpetriere Hospital, Paris (France); Roger, B. [Clinique des Lilas, Paris (France); Cerri, G.G. [Department of Radiology, University of Sao Paulo (Brazil)

    2007-09-15

    Aim: To evaluate the cross-sectional area of the median nerve using ultrasound in carpal tunnel syndrome patients before and after endoscopic intervention. Material and methods: Twenty patients with carpal tunnel syndrome (15 women and five men; mean age 55 years) were prospectively evaluated. Informed consent was obtained from all participants. The study was approved by our Institutional Review Board (IRB). Median nerve cross-sectional area was evaluated at the proximal level before and at 4, 8, and 12 weeks after endoscopic release of the transverse ligament. In the present study, the median nerve cross-sectional area cut-off point was 10 mm{sup 2}. Repeated measures analysis of variance test (ANOVA) was applied to compare the reproducibility of ultrasound measurements before and after intervention. Results: The mean cross-sectional area of the median nerve was 15 mm{sup 2} (SD {+-} 2.1) before surgery; and 11.1 mm{sup 2} (SD {+-} 3); 9.2 mm{sup 2} (SD {+-} 2); and 8.6 mm{sup 2} (SD {+-} 1.6) at 4, 8, and 12 weeks after surgery. Repeated measures analyses of variance were found to be statistically significant (p < 0.001). Conclusion: The results of the present study demonstrated that there was a decrease in the cross-sectional area of the median nerve after the release of the transverse carpal ligament.

  13. Profiling of Sediment Microbial Community in Dongting Lake before and after Impoundment of the Three Gorges Dam.

    Science.gov (United States)

    Huang, Wei; Jiang, Xia

    2016-01-01

    The sediment microbial community in downstream-linked lakes can be affected by the operation of large-scale water conservancy projects. The present study determined Illumina reads (16S rRNA gene amplicons) to analyze and compare the bacterial communities from sediments in Dongting Lake (China) before and after impoundment of the Three Gorges Dam (TGD), the largest hydroelectric project in the world. Bacterial communities in sediment samples in Dongting Lake before impoundment of the TGD (the high water period) had a higher diversity than after impoundment of the TGD (the low water period). The most abundant phylum in the sediment samples was Proteobacteria (36.4%-51.5%), and this result was due to the significant abundance of Betaproteobacteria and Deltaproteobacteria in the sediment samples before impoundment of the TGD and the abundance of Gammaproteobacteria in the sediment samples after impoundment of the TGD. In addition, bacterial sequences of the sediment samples are also affiliated with Acidobacteria (11.0% on average), Chloroflexi (10.9% on average), Bacteroidetes (6.7% on average), and Nitrospirae (5.1% on average). Variations in the composition of the bacterial community within some sediment samples from the river estuary into Dongting Lake were related to the pH values. The bacterial community in the samples from the three lake districts of Dongting Lake before and after impoundment of the TGD was linked to the nutrient concentration. PMID:27338434

  14. Profiling of Sediment Microbial Community in Dongting Lake before and after Impoundment of the Three Gorges Dam

    Directory of Open Access Journals (Sweden)

    Wei Huang

    2016-06-01

    Full Text Available The sediment microbial community in downstream-linked lakes can be affected by the operation of large-scale water conservancy projects. The present study determined Illumina reads (16S rRNA gene amplicons to analyze and compare the bacterial communities from sediments in Dongting Lake (China before and after impoundment of the Three Gorges Dam (TGD, the largest hydroelectric project in the world. Bacterial communities in sediment samples in Dongting Lake before impoundment of the TGD (the high water period had a higher diversity than after impoundment of the TGD (the low water period. The most abundant phylum in the sediment samples was Proteobacteria (36.4%–51.5%, and this result was due to the significant abundance of Betaproteobacteria and Deltaproteobacteria in the sediment samples before impoundment of the TGD and the abundance of Gammaproteobacteria in the sediment samples after impoundment of the TGD. In addition, bacterial sequences of the sediment samples are also affiliated with Acidobacteria (11.0% on average, Chloroflexi (10.9% on average, Bacteroidetes (6.7% on average, and Nitrospirae (5.1% on average. Variations in the composition of the bacterial community within some sediment samples from the river estuary into Dongting Lake were related to the pH values. The bacterial community in the samples from the three lake districts of Dongting Lake before and after impoundment of the TGD was linked to the nutrient concentration.

  15. Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication

    Directory of Open Access Journals (Sweden)

    Sadegh Massarrat

    2014-01-01

    Full Text Available Background. The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication. Methods. First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years after H. pylori eradication. The morphological changes in two categories (normal to mild and moderate to severe were compared with level of pepsinogens I and II before eradication (n=369, after eradication (n=115, and in those with persistent infection (n=250. Results: After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values. Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change. After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL, higher pepsinogen II (9.4 versus 6.9 μ/mL, and lower ratio (7.9 versus 11.6 than those without (P<0.05. Conclusion. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.

  16. Profiling of Sediment Microbial Community in Dongting Lake before and after Impoundment of the Three Gorges Dam

    Science.gov (United States)

    Huang, Wei; Jiang, Xia

    2016-01-01

    The sediment microbial community in downstream-linked lakes can be affected by the operation of large-scale water conservancy projects. The present study determined Illumina reads (16S rRNA gene amplicons) to analyze and compare the bacterial communities from sediments in Dongting Lake (China) before and after impoundment of the Three Gorges Dam (TGD), the largest hydroelectric project in the world. Bacterial communities in sediment samples in Dongting Lake before impoundment of the TGD (the high water period) had a higher diversity than after impoundment of the TGD (the low water period). The most abundant phylum in the sediment samples was Proteobacteria (36.4%–51.5%), and this result was due to the significant abundance of Betaproteobacteria and Deltaproteobacteria in the sediment samples before impoundment of the TGD and the abundance of Gammaproteobacteria in the sediment samples after impoundment of the TGD. In addition, bacterial sequences of the sediment samples are also affiliated with Acidobacteria (11.0% on average), Chloroflexi (10.9% on average), Bacteroidetes (6.7% on average), and Nitrospirae (5.1% on average). Variations in the composition of the bacterial community within some sediment samples from the river estuary into Dongting Lake were related to the pH values. The bacterial community in the samples from the three lake districts of Dongting Lake before and after impoundment of the TGD was linked to the nutrient concentration. PMID:27338434

  17. Eye movements and visuoverbal descriptions exhibit heterogeneous and dissociated patterns before and after prismatic adaptation in unilateral spatial neglect.

    Science.gov (United States)

    Datié, A-M; Paysant, J; Destainville, S; Sagez, A; Beis, J-M; André, J-M

    2006-07-01

    This prospective study examined the effects of prismatic adaptation on visual exploration strategies in patients with left unilateral spatial neglect (USN). Photo-oculographic gaze recordings were obtained, as the subjects (28 brain-damaged; 15 control) performed a free visual exploration task before and after a session of prismatic adaptation. (i) Before prismatic adaptation, the pattern of visual exploration described two subgroups of patients (symmetrical exploration of hemispaces - similar to the control subjects, deficient exploration of left hemispace). Twelve of 20 patients failed to describe significant elements in the left part of the displayed image. Several visuoverbal patterns were observed, some dissociating visual exploration and verbal description. (ii) Immediately after prismatic adaptation, patients with asymmetrical visual exploration presented a significant increase in the number of point fixations and saccades in the left hemispace. Patients with symmetrical exploration presented the opposite pattern. Improved pattern of visual exploration contrasted with an absence of improved verbal description. Eye movements and visuoverbal descriptions exhibit heterogeneous and dissociated patterns before and after prismatic adaptation. This results demonstrate that prismatic adaptation has no effect in certain patients, suggesting that therapeutic indications and evaluation of prismatic test results should take into consideration the heterogeneous nature of USN.

  18. Profile of hepatocyte apoptosis and bile lakes before and after bile duct decompression in severe obstructive jaundice patients

    Institute of Scientific and Technical Information of China (English)

    ToarJMLalisang; RadenSjamsuhidajat; NurjatiCSiregar; AkmalTaher

    2010-01-01

    BACKGROUND: Excessive hepatocyte apoptosis and bile lakes in severe obstructive jaundice might impair liver functions. Although decompression of the bile duct has been reported to improve liver functions in animal studies, the mechanism of obstruction differs from that in humans. This study aimed to determine the profiles of hepatocyte apoptosis and bile lakes following bile duct decompression in patients with severe obstructive jaundice in the clinical setting. METHODS: We conducted a "before and after study" on severe obstructive jaundice patients as a model of inhibition of the excessive process by bile duct decompression. Specimens of liver biopsies were taken before and after decompression of the bile duct and then stained by terminal deoxynucleotide transferase-mediated dUTP nick end-labeling (TUNEL) to identify hepatocyte apoptosis and by hematoxilin-eosin (HE) to identify bile lakes. All measurements were independently done by 2 observers. RESULTS: Twenty-one severe obstructive jaundice patients were included. In all patients, excessive hepatocyte apoptosis and bile lakes were apparent. After decompression, the hepatocyte apoptosis index decreased from 53.1 (SD 105) to 11.7 (SD 13.6) (P CONCLUSION: Bile duct decompression improves hepatocyte apoptosis and bile lakes in cases of severe obstructive jaundice, similar to the findings in animal studies.

  19. Identification of new ovulation-related genes in humans by comparing the transcriptome of granulosa cells before and after ovulation triggering in the same controlled ovarian stimulation cycle

    DEFF Research Database (Denmark)

    Wissing, M L; Kristensen, S G; Andersen, C Y;

    2014-01-01

    with ovarian cancer, while down-regulated genes mainly represented cell cycle and proliferation. WHAT IS KNOWN ALREADY: Radical changes occur in the follicle during final follicle maturation after the ovulatory trigger: these range from ensuring an optimal milieu for the oocyte in meiotic arrest to the release...... of a mature oocyte and remodeling into a corpus luteum. A wide range of mediators of final follicle maturation has been identified in rodents, non-human primates and cows. STUDY DESIGN, SIZE, DURATION: Prospective cohort study including 24 women undergoing ovarian stimulation with the long gonadotrophin-releasing...... hormone agonist protocol during 2010-2012 at Holbæk Fertility Clinic. Nine paired samples of GC and 24 paired samples of follicular fluid (FF) were obtained before and after recombinant human chorionic gonadotrophin (rhCG) administration. PARTICIPANTS/MATERIALS, SETTING, METHODS: Nine paired (nine arrays...

  20. Cross shift changes in lung function among bar and restaurant workers before and after implementation of a smoking ban

    Science.gov (United States)

    Skogstad, M; Kjærheim, K; Fladseth, G; Gjølstad, M; Daae, H L; Olsen, R; Molander, P; Ellingsen, D G

    2006-01-01

    Objective To study possible cross shift effects of environmental tobacco smoke (ETS) on pulmonary function among bar and restaurant employees before and after the implementation of a smoking ban in Norway. Methods The study included 93 subjects employed in 13 different establishments in Oslo. They were examined at the beginning and end of a workshift both while ETS exposure was present and when smoking was banned. The mean exposure level of nicotine and total dust before the ban was 28 μg/m3 (range 3–65) and 275 μg/m3 (range 81–506), respectively. Following the smoking ban, the mean level of nicotine and total dust was 0.6 μg/m3 and 77 μg/m3, respectively. Assessment of lung function included dynamic lung volumes and flows. Results The cross shift reduction in forced vital capacity (FVC) among 69 subjects participating in both examinations changed from 81 ml (SD 136) during exposure to ETS to 52 ml (SD 156) (p = 0.24) following the smoking ban. The reduction in forced expired volume in one second (FEV1) during a workshift, was borderline significantly reduced when comparing the situation before and after the intervention, by 89 ml (SD = 132) compared to 46 ml (SD = 152) (p = 0.09), respectively. The reduction in forced mid‐expiratory flow rate (FEF25–75%) changed significantly from 199 ml/s (SD = 372) to 64 ml/s (SD = 307) (p = 0.01). Among 26 non‐smokers and 11 asthmatics, the reduction in FEV1 and FEF25–75% was significantly larger during ETS exposure compared to after the smoking ban. There was an association between the dust concentration and decrease in FEF25–75% before the ban among non‐smokers (p = 0.048). Conclusions This first study of cross shift changes before and after the implementation of a smoking ban in restaurants and bars shows a larger cross shift decrease in lung function before compared with after the implementation of the ban. PMID:16551754

  1. Vascular endothelial growth factor before and after locoregional treatment and its relation to treatment response in hepatocelluar carcinoma patients

    Institute of Scientific and Technical Information of China (English)

    Heba; Sedrak; Noaman; El-Garem; Mervat; Naguib; Heba; El-Zawahry; Mohamed; Esmat; Lila; Rashed

    2015-01-01

    Objective:To evaluate vascular endothelial growth factor(VEGF)levels in hepatocellular carcinoma patients before and after transcatheter arterial chemoembolization(TACE)and percutaneous ethanol injection(PEI)and its relation to treatment response.Methods:A total of 40 patients with unrespectable hepatocelluar carcinoma were assessed clinically.Twenty patients were suitable to be treated by TACE,while other 20patients were treated with PEI.Serum VEGF levels were measured before and 1 month after each procedure by ELISA.Response was assessed after 1 month according to Union Internationale Contre le Cancer evaluation criteria based on change in tumor size as measured by ultrasound.Results:There was no significant difference between TACE and PEI groups with regard to age,sex,tumor size,response to local therapy,or VEGF and alpha-fetoprotein before and after therapy.VEGF levels after TACE were significantly higher than before TACE[(298.1±123.6)pg/m L vs.(205.8±307.3)pg/m L;P=0.001].Also,VEGF levels were significantly higher after PEI than before PEI[(333.8±365.6)pg/m L vs.(245.3±301.8)pg/m L;P=0.000].Non-responders of both groups had significantly high VEGF levels than responder’s,both before[(985.0±113.2)pg/m L vs.(117.1±75.3)pg/m L;P<0.001]and after therapy[(1 330.6±495.7)pg/m L vs.(171.0±94.7)pg/m L;P=0.000)].Conclusions:Both TACE and PEI were associated with an increase in serum VEGF in hepatocelluar carcinoma patients.Higher levels of VEGF before and after therapy were found in non-responders,suggesting that VEGF is a useful marker in predicting treatment response.

  2. The change of portal hemodynamics before and after transjugular intrahepatic portosystemic shunt according to variceal type: gastric and esophageal varix

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee Sang; Kim, Jae Kyu; Koe, Eun Hae; Lim, Hyo Son; Cho, Yong Ho; Park, Jin Gyoon; Kang, Heoung Keun; Kim, Sei Jong [Medical School, Chonnam University, Kwanju (Korea, Republic of)

    2000-09-01

    To investigae the changes occurring in portal hemodynamics in patients with esophageal and gastric varices, according to variceal type, before and after TIPS. Between January 1994 and after June 1999, we evaluated 22 of 44 patients who had undergone TIPS and endoscopy on admission. In these 22, hepatic venous and main portal venous pressure were measured. On the basis of endoscopic findings, the esophageal and gastric varices were classified as one of three types. Changes in portal hemodynamics in relation to the diameter of the portal vein, mean portosystemic gradient before and after TIPS, {delta}MPSG, and the presence of hepatic encephalopathy and gastrorenal shunt were all evaluated. Endoscopy indicated that there were ten Type-I cases, nine Type-II, and three Type-III. The diameter of the main portal vein was 14.95 {+-} 1.79 mm in Type I cases, and 13.35 {+-} 1.59 mm in Type II. Before TIPS, main portal venous pressure was 31.40 {+-} 6.79 mmHg (Type I) 22.80 {+-}4.26 mmHg (Type II), and the mean portosystemic gradient was 16.10 {+-} 7.0 mmHg (Type I), 11.20 {+-} 5.36 mmHg (Type II). After TIPS, the pressure readings were 25.70 {+-}7.60 mmHg (Type I) and 17.80 {+-} 6.52 mmHg (Type II), while those relating to were 10.80 {+-} 4.94 mmHg (Type I) and 5.25 {+-} 3.67 mmHg (Type II). {delta}MPSG was 6.04 {+-} 2.98 mmHg (Type I) and 5.91 {+-} 3.98 mmHg (Type II). Angiography revealed that the gastrorenal shunt was Type I in 10% of cases, Type II in 77%, and Type III in 33%. Hepatic encephalopathy after TIPS occured in three Type-I cases, three Type-II, and two Type-III. The diameter of the main portal vein was significantly smaller, and portal venous pressure and mean portosystemic gradient before and after TIPS significantly lower in patients with dominant gastric varices than in those with dominant esophageal varices (p less than 0.05). Gastrorenal shunt was more frequent amomg patients with dominant gastric varices. No difference in the incidence of hepatic

  3. [Analysis on component difference in Citrus reticulata before and after being processed with salt by UPLC-Q-TOF/MS].

    Science.gov (United States)

    Zeng, Rui; Fu, Juan; Wu, La-Bin; Huang, Lin-Fang

    2013-07-01

    To analyze components of Citrus reticulata and salt-processed C. reticulata by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS), and compared the changes in components before and after being processed with salt. Principal component analysis (PCA) and partial least squares discriminant analysis (OPLS-DA) were adopted to analyze the difference in fingerprint between crude and processed C. reticulata, showing increased content of eriocitrin, limonin, nomilin and obacunone increase in salt-processed C. reticulata. Potential chemical markers were identified as limonin, obacunone and nomilin, which could be used for distinguishing index components of crude and processed C. reticulata. PMID:24199563

  4. IL-1, IL-4 production and IgE levels in acute and chronic fasciolosis before and after triclabendazole treatment.

    Science.gov (United States)

    Allam, A F; Osman, M M; el-Sayed, M H; Demian, S R

    2000-12-01

    IL-1 generation by mononuclear phagocytes, IL-4 production by Th2 lymphocytes and IgE levels in serum were measured in eight patients with acute fasciolosis and seven patients in the chronic stage of the disease before and after triclabendazole treatment. Results were compared with those of a control group of ten individuals. The monocytes and lymphocytes from patients with acute and chronic fasciolosis produced significantly lower levels of IL-1 and IL-4 respectively, particularly in the chronic phase of the disease, as compared to the control. A significant increase in IgE level in both acute and chronic fasciolosis was observed. The level was significantly higher in acute as compared to chronic cases. After treatment with triclabendazole IL-1, IL-4 and IgE levels moved towards the control indicating obvious improvement in the immunological responses of the patients. PMID:11198376

  5. Mössbauer studies of iron doped poly(methyl methacrylate) before and after ion beam modification

    Indian Academy of Sciences (India)

    D R S Somayajulu; C N Murthy; D K Awasthi; N V Patel; M Sarkar

    2001-08-01

    High-energy MeV ions from accelerators are known to produce drastic modifications in polymers. The typical effects include chain scissions, crosslinks, molecular emission and double bond formation. Poly(methyl methacrylate) was doped with Fe(III) and irradiated with 95 MeV O7+ ions. 57Fe-Mössbauer studies were done on the doped samples before and after irradiation. Before irradiation, no Mössbauer absorption was observed. The irradiated samples showed a good Mössbauer absorption, which seems to indicate that there is a significant interaction between the metal ion and the polymer matrix. Two possibilities exist at these doses (∼ 22 × 1012 ions/cm): Fe(III) ions may be bridging the various polymer segments through crosslinking or amorphization of the sample leading to Fe–C bonding. Studies of FTIR, conductivity and glass transition temperatures on these samples support these observations.

  6. Elemental analysis of ash residue from combustion of CCA treated wood waste before and after electrodialytic extraction

    DEFF Research Database (Denmark)

    Pedersen, Anne Juul; Ottosen, Lisbeth M.

    2006-01-01

    Element distribution in a combined fly ash and bottom ash from combustion of copper chromate arsenate (CCA) treated wood waste was investigated by scanning electron microscopy (SEM/EDX) before and after electrodialytic extraction. The untreated ash contained various particles, including pieces...... in the incompletely combusted wood pieces and was also found in almost pure form in a surface layer of some matrix particles – indicating surface condensation of volatile Cu species. In treated ash, Ca and As were no longer found together, indicating that Ca-arsenates had been dissolved due to the electrodialytic....... Chemical analyses of untreated and treated ash confirmed that most As, but only smaller amounts of Cu and Cr was removed due to the electrodialytic extraction. Overall metal contents in the original ash residue were: 1.4 g As, 2.76 g Cu and 2.48 g Cr, after electrodialytic extraction these amounts were...

  7. Role of Cardiac Imaging (CT/MR Before and After RF Catheter Ablation in Patients with Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Aravindan Kolandaivelu, MD

    2012-08-01

    Full Text Available Pre-procedure X-ray computed tomography (CT and magnetic resonance imaging (MRI angiography are commonly used to delineate the complex and variable relationship of the left atrium, pulmonary veins, and surrounding structures. 3D CT and MR angiography are routinely incorporated into electroanatomic mapping systems to guide ablation lesion placement in the context of patient specific anatomy. Post-procedure CT and MRI have also proven useful for evaluating complications such as pulmonary vein stenosis. In the future, these imaging modalities may be used to visualize more detailed tissue characteristics such as atrial fibrosis and ablation lesions. This could improve selection of patients for different treatment strategies and perhaps guide more effective ablation. This review will discuss current and emerging applications of CT and MRI before and after radiofrequency catheter ablation of atrial fibrillation.

  8. Iodine isotopes in precipitation: Four-year time series variations before and after 2011 Fukushima nuclear accident

    DEFF Research Database (Denmark)

    Xu, Sheng; Zhang, Luyuan; Freeman, Stewart P. H. T.;

    2016-01-01

    Rainwater samples were collected monthly from Fukushima, Japan, in 2012-2014 and analysed for 127I and 129I. These are combined with previously reported data to investigate atmospheric levels and behaviour of Fukushima-derived 129I before and after the 2011 nuclear accident. In the new datasets...... values in winter and spring-summer. The high 129I levels in winter and spring-summer are most likely attributed to local resuspension of the Fukushima-derived radionuclide-bearing fine soil particles deposited on land surfaces, and re-emission through vegetation taking up 129I from contaminated soil...... and water, respectively. Long-term declining rate suggests that contribution of the Fukushima-derived 129I to the atmosphere would become less since 2014....

  9. Mensuration of cardioangiopulmonary indices by radiocardiogram before and after the verapamil oral administration in subjects with chronic obstructive pulmonary disease

    International Nuclear Information System (INIS)

    Twenty subjects with chronic obstructive pulmonary disease were studied. The diagnosis was obtained from the history, clinical evaluation, pulmonary radiography, pulmonary and hepatic scintigraphies and spirometry. About 360 mg of verapamil was administered daily, every eight hours for ten days. Before and after drug administration, the arterial pressures, the spirometric measurements and nine cardiac roentgenographic indexes were measured. Vital capacity increased in all cases, but did not reach the normal levels. These data suggest that the effect of verapamil on the pulmonary circulation brought benefits to the subjects. This occurred either by direct pulmonary vasodilation, or by bronchodilation, reducing hypoxia. In all cases, the pulmonary resistance was diminished. Finally, verapamil seems to be a drug with real benefits in subjects with chronic obstructive pulmonary disease and we advise a continuation of the studies. (author)

  10. Study on ventilation-perfusion lung scintigraphy before and after closed surgery for atrial septal defect with persistent ostium secundum

    International Nuclear Information System (INIS)

    To examine changes of ventilation and perfusion distribution before and after closed surgery in atrial septal defect (ASD), a total of 25 ventrilation-perfusion lung scintigraphies were performed in a supine position in 15 ASD patients. Their ages ranged from one year and 11 months to 23 years (an average age of 7 years and one month). Ventilation and perfusion distribution was almost uniform before surgery. Preoperative time constant obtained from Xe-133 washout curve had a positive correlation with pulmonary blood flow per pulmonary volume. Although preoperative higher perfusion was seen in the upper lobe, perfusion tended to be uniform after surgery. Non-uniform distribution of ventilation/perfusion ratio became uniform within a few weeks after surgery. (N.K.)

  11. ROLE OF PERIPHERAL LYMPHOCYTES SIALYL LEWIS(X) (CD15s)ANTIGEN BEFORE AND AFTER KIDNEY TRANSPLANTATION

    Institute of Scientific and Technical Information of China (English)

    Pan Xiaoming; Wang Yong; Xue Wujun; Tian Puxun

    2006-01-01

    Objective To investigate the role of peripheral lymphocytes Sialyl Lewis(x) (CD15s) antigen before and after kidney transplantation. Methods Flow cytometry technique was applied to examine the expression of peripheral lymphoid cell surface CD15s antigen after renal transplantation, and to evaluate various therapeutic regimen. Results The statistic analysis results of peripheral lymphoid cell surface CD15s antigen expression level showed that there was significant difference among the patients with acute rejection, long-term dialysis and with normal renal function post-transplant; significant difference of CD15s expression level between group of rejection and infection; no significant difference of CD15s expression among the different groups treated by various therapeutic regimens. Conclusion The different therapeutic regimen has no influence to CD15s expression; Detection of peripheral lymphoid cell surface CD15s antigen expression periodically, intelligently make convenience to understand suitable status of immunosuppression.

  12. IL-1, IL-4 production and IgE levels in acute and chronic fasciolosis before and after triclabendazole treatment.

    Science.gov (United States)

    Allam, A F; Osman, M M; el-Sayed, M H; Demian, S R

    2000-12-01

    IL-1 generation by mononuclear phagocytes, IL-4 production by Th2 lymphocytes and IgE levels in serum were measured in eight patients with acute fasciolosis and seven patients in the chronic stage of the disease before and after triclabendazole treatment. Results were compared with those of a control group of ten individuals. The monocytes and lymphocytes from patients with acute and chronic fasciolosis produced significantly lower levels of IL-1 and IL-4 respectively, particularly in the chronic phase of the disease, as compared to the control. A significant increase in IgE level in both acute and chronic fasciolosis was observed. The level was significantly higher in acute as compared to chronic cases. After treatment with triclabendazole IL-1, IL-4 and IgE levels moved towards the control indicating obvious improvement in the immunological responses of the patients.

  13. The Dynamics and Structural Changes of Foreign Direct Investments In Romania � before and after the Recent Global Crisis

    Directory of Open Access Journals (Sweden)

    Ramona Mariana Calinica

    2016-07-01

    Full Text Available In the context of the economic globalisation and level of openness increase of various countries� economies to the rest of world, more and more enterprises extended their activity over their national borders, therefore the foreign direct investments being considered key elements in the process of economic integration, playing a major role in the host country�s economy. The aim of this paper consists in realising an in-depth analysis of the FDIs� volume, structure and dynamics in Romania before and after the recent global crisis, on types, sectors and branches, development regions and origin countries, by highlighting in the same time their impact over Romania�s balance of trade.

  14. Survival in women with ovarian cancer before and after the introduction of adjuvant paclitaxel; a 25-year, single institution review.

    LENUS (Irish Health Repository)

    Shireen, R

    2012-02-01

    Adjuvant chemotherapy regime for ovarian cancer patients remains to be a contentious issue. The aim of this study was to compare the overall and progression-free survival of women with ovarian cancer before and after introduction of paclitaxel in our unit in 1992. A sample of 112 women who received adjuvant therapy following surgery for ovarian cancer was collected, 68 (61%) received platinum+alkylating agent before 1992 and later 44 (39%) received platinum+paclitaxel. Five-year survival was same in both treatment groups when there was no macroscopic disease after surgery (78% versus 70%) and when residual disease was <2 cm (50% versus 40%). Survival was greater in women with residual disease >2 cm in the platinum+paclitaxel group (50% versus 24%), (p = 0.04). However, progression-free survival was similar in both groups irrespective of stage or residual volume of disease. Therefore consideration to selective use of paclitaxel could reduce patient morbidity and costs significantly.

  15. Changes of plasma ET and serum IgE levels in children with asthma before and after allergen immunotherapy (AIT)

    International Nuclear Information System (INIS)

    Objective: To investigate the relationship between the changes of plasma ET-1, serum IgE levels and allergen immunotherapy(AIT) in children with asthma. Methods: Plasma levels of ET-1 and serum levels of IgE were measured with radioimmunoassay in 46 children with asthma before and after allergen immunotherapy. Results: In 35 patients benefited from allergen immunotherapy, the plasma levels of ET-1 (59.1 ± 11.7pg/ml) and serum levels of IgE (11.1 ± 3.2IU/ml) were higher significantly than those in controls (P0.05, respectively). Conclusion: These data suggested that the changes of ET-1 and IgE levels after AIT may play an important role in the effective treatment of asthma with AIT. (authors)

  16. CT studies before and after CNS treatment for acute lymphoblastic leukemia and malignant non-Hodgkin's lymphoma in childhood

    International Nuclear Information System (INIS)

    CT was performed on 72 children with acute lymphoblasitc leukemia or non-Hodgkin's lymphoma. Thirty-two of these patients were investigated prior to CNS radiation and intrathecal methotrexate therapy. Ten of these patients (31%) were known to have hydrocephalic dilatation of the CSF spaces. Clinical data and subsequent observations with analysis of the CT findings show that no difference in the attenuation values of brain tissue occurs in the absence of a CNS relapse. The percentage of abnormal findings before and after therapy remains constant. The adverse late effects described in the CT literature seem principally to be damage diagnosed too late. It is questionable if the CT demonstration of dilated CSF spaces before treatment has a prognostic significance. (orig.)

  17. Knee joint biomechanics and neuromuscular control during gait before and after total knee arthroplasty are sex-specific.

    Science.gov (United States)

    Astephen Wilson, Janie L; Dunbar, Michael J; Hubley-Kozey, Cheryl L

    2015-01-01

    The future of total knee arthroplasty (TKA) surgery will involve planning that incorporates more patient-specific characteristics. Despite known biological, morphological, and functional differences between men and women, there has been little investigation into knee joint biomechanical and neuromuscular differences between men and women with osteoarthritis, and none that have examined sex-specific biomechanical and neuromuscular responses to TKA surgery. The objective of this study was to examine sex-associated differences in knee kinematics, kinetics and neuromuscular patterns during gait before and after TKA. Fifty-two patients with end-stage knee OA (28 women, 24 men) underwent gait and neuromuscular analysis within the week prior to and one year after surgery. A number of sex-specific differences were identified which suggest a different manifestation of end-stage knee OA between the sexes.

  18. Price elasticities in the German Statutory Health Insurance market before and after the health care reform of 2009.

    Science.gov (United States)

    Pendzialek, Jonas B; Danner, Marion; Simic, Dusan; Stock, Stephanie

    2015-05-01

    This paper investigates the change in price elasticity of health insurance choice in Germany after a reform of health insurance contributions. Using a comprehensive data set of all sickness funds between 2004 and 2013, price elasticities are calculated both before and after the reform for the entire market. The general price elasticity is found to be increased more than 4-fold from -0.81 prior to the reform to -3.53 after the reform. By introducing a new kind of health insurance contribution the reform seemingly increased the price elasticity of insured individuals to a more appropriate level under the given market parameters. However, further unintended consequences of the new contribution scheme were massive losses of market share for the more expensive sickness funds and therefore an undivided focus on pricing as the primary competitive element to the detriment of quality. PMID:25670009

  19. Glucose-induced thermogenesis in patients with small cell lung carcinoma. Before and after inhibition of tumour growth by chemotherapy

    DEFF Research Database (Denmark)

    Simonsen, L; Bülow, J; Sengeløv, H;

    1993-01-01

    Seven weight-losing patients with histologically verified small cell lung carcinoma were given an oral glucose load of 75 g before and at least 3 weeks after the end of chemotherapy to examine the effect of glucose on whole body and skeletal muscle thermogenesis before and after reduction of tumour....... Whole body energy expenditure was measured by the open circuit ventilated hood system. Forearm blood flow was measured by venous-occlusion strain-gauge plethysmography. The uptake of oxygen in skeletal muscle was calculated as the product of the forearm blood flow and the difference in a-v oxygen....... This is significantly increased compared to that found in a healthy control group (74.7 +/- 4.8 kJ 180 min-1, P muscles was 6.9 +/- 0.3 mumol 100 g-1 min...

  20. Activity of the neuroendocrine axes in patients with polymyalgia rheumatica before and after TNF-α blocking etanercept treatment

    DEFF Research Database (Denmark)

    Kreiner, Frederik Flindt; Galbo, Henrik

    2012-01-01

    treatment in patients, levels had decreased (P hormones never differed significantly between groups (P > 0.05). CONCLUSIONS: In PMR, TNF-α may increase the activities of the hypothalamic-pituitary-adrenal and the hypothalamic......-reactive protein (CRP) markedly in PMR. METHODS: Plasma samples were collected from 10 glucocorticoid-naïve patients with PMR and 10 matched controls before and after etanercept treatment (25 mg biweekly for 2 weeks). The primary end points were pre- and posttreatment levels of adrenocorticotropic hormone (ACTH......), cortisol, adrenaline, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), prolactin, and insulin-like growth factor 1 (IGF-1). RESULTS: Before TNF-α-blocking treatment, plasma TNF-α, ACTH, and cortisol levels were higher in patients versus controls (P

  1. Health care providers′ acceptance of unsedated colonoscopy before and after a state-of-the-art lecture on the feasibility of the option

    Directory of Open Access Journals (Sweden)

    Felix W Leung

    2012-01-01

    Full Text Available Background/Aim: The impact of education on acceptance of unsedated colonoscopy by health care providers is unknown. To test the hypothesis that knowledge imparted by a lecture on unsedated colonoscopy is associated with its enhanced acceptance. Settings and Design: At the State-of-the-Art Lecture on "Unsedated colonoscopy: Is it feasible?" presented at the 8 th Pan-Arab Conference on Gastroenterology, February, 2011, Riyadh, Saudi Arabia, a questionnaire survey of the audience was undertaken. Materials and Methods: An expectation questionnaire was administered before and after the lecture. Attendees responded anonymously. Statistical analysis used: The responses of a convenient sample of 49 attendees who provided completed responses to the questionnaire both before and after the lecture were analyzed. Data are expressed as frequency counts and means±SEM. Repeated measures analysis of variance (ANOVA, ANOVA with contrasts and Chi-square analysis (Statview II Program for Macintosh computers were used to assess the data. A P value of <0.05 is considered significant. Results and Conclusions: The mean±SEM credibility score (maximum possible score=50 was 25.8 ± 1.8 before and 33.3 ± 2.1 after the lecture, with a significant improvement in mean score of 7.5 ± 1.3 (P=0.001, paired t test. Nineteen (39% respondents were not willing to consider unsedated colonoscopy for themselves before the lecture. This number decreased to 13 (27% after the lecture. Before the lecture only 4 (8% respondents were willing to consider unsedated colonoscopy for themselves. After the lecture this number increased to 8 (16%. The data suggest education of healthcare professionals regarding the feasibility of unsedated colonoscopy appears to enhance its acceptance as a credible patient care option at a Pan-Arab Gastroenterology Conference.

  2. HIV, syphilis, and behavioral risk factors among female sex workers before and after implementation of harm reduction programs in a high drug-using area of China.

    Directory of Open Access Journals (Sweden)

    Li Zhang

    Full Text Available OBJECTIVE: To evaluate the impact of harm reduction programs on HIV and syphilis infection and related risk behaviors among female sex workers (FSWs in a drug trafficking city in Southwest China. DESIGN: Before and after harm reduction program study. METHODS: Two cross-sectional surveys were conducted among FSWs before and after harm reduction programs were launched in Xichang city, Sichuan province. The first and second cross-sectional surveys were conducted in 2004 and 2010, respectively. Temporal changes in odds of HIV, syphilis, and behavioral risk factors were assessed by multivariable logistic regression while controlling for socio-demographics. RESULTS: The 2004 and 2010 cross-sectional surveys recruited 343 and 404 FSWs, respectively. From 2004 to 2010, the odds of syphilis infection decreased by 35% and was of borderline statistical significance (AOR: 0.65, 95% CI: 0.41-1.03, while odds of HIV infection rose, but not significantly (AOR: 4.12, 95% CI: 0.76-22.45. Although odds of unprotected sex with primary sex partners did not significantly change over time (AOR: 0.96; 95% CI: 0.61-1.50, odds of unprotected sex with clients declined significantly and remarkably (AOR: 0.14, 95% CI: 0.09-0.21. Notably, the odds of reporting ≥10 new sex partners in the previous month increased by 37% (AOR: 1.37; 95% CI: 0.98-1.90. CONCLUSIONS: Harm reduction strategies may be an effective means of reducing unprotected sex with clients among FSWs. Future research is needed to better target both FSWs and IDUs and interrupt bridging networks for HIV transmission in high drug-using areas of China.

  3. Psychosocial well-being of people living with HIV and the community before and after a HIV stigma-reduction community "hub" network intervention.

    Science.gov (United States)

    Prinsloo, Catharina D; Greeff, Minrie; Kruger, Annamarie; Ellis, Suria

    2016-09-01

    The purpose of the research was to determine whether an HIV stigma-reduction community "hub" network intervention in a South African urban area would bring about a difference in the psychosocial well-being of people living with HIV (PLWH), as well as their community (living in the same municipal ward). A single case pre-test post-test design was implemented. The sample for this study included 62 PLWH who were selected through accessibility sampling and 570 community members who were selected through random voluntary sampling. Participants completed the Patient Health Questionnaire (PHQ-9) and the Mental Health Continuum-Short Form (MHC-SF) before and after the intervention. A dependent t-test as well as Cohen's d-values were used to calculate the differences between the pre- and post-test results for depression and well-being. Levels of languishing, moderate mental health and flourishing before and after the intervention were determined. Although the focus of the HIV stigma-reduction community "hub" intervention that was followed in this study was on the involvement of PLWH and people living close to them (PLC) to share their knowledge as community mobilisers and to mobilise and empower their own community to reduce HIV stigma, it can be concluded that a secondary gain was the effect it had on both depression and mental health of the PLWH as well as the community. Of interest is how these effects differed for PLWH and the community. It is thus recommended that future interventions should give special attention to aspects of depression and well-being. PMID:27681150

  4. ¹H-MRS before and after resuscitation following selective cerebral ultra-profound hypothermic blood flow occlusion in monkeys.

    Science.gov (United States)

    Niu, X-Q; Zhao, X-X; Li, B-C; Gao, Y-J; Xu, W; Fan, Y-D; Fu, G-P; Wang, K; Pu, J

    2015-01-01

    We investigated the effect of selective cerebral ultra-profound hypothermic blood flow occlusion on brain tissue and cell metabolism to ascertain the efficacy and safety of selective deep hypothermic technologies using proton magnetic resonance spectroscopy ((1)H-MRS). The bilateral carotid artery was blocked at room temperature for 10 min. Other neck vessels were then blocked through cold perfusion of the internal carotid artery and reflux of the ipsilateral jugular vein. Thus, selective cerebral extracorporeal circulation was established. Brain temperature was reduced to 15.1° ± 0.9°C. After 60 min, cerebral blood flow recovered naturally. Routine magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and (1)H-MRS examination of the bilateral frontal cortex and basal ganglia were performed prior to surgery and 4, 24, 72 h, 21 days after recovery. The formants and areas under the curve (AUC) of N-acetyl aspartate (NAA), choline (Cho), creatine/phosphocreatine (Cr/Cr2) were analyzed using 1H-MRS. The pre- and postoperative AUC of NAA and Cho at different time points were compared. Conventional MRI and DWI showed no abnormal signal changes in the brain parenchyma or right basal ganglia before and after surgery (P > 0.05). There was no significant difference in the ratio between NAA/(Cr+Cr2) and Cho/(Cr+Cr2) before and after surgery in the bilateral basal ganglia and frontoparietal regions of the cortex (P > 0.05). Quantitative (1)H-MRS showed that selective deep cerebral hypothermia significantly improved the brain's tolerance to ischemia and hypoxia. Our results could provide a better understanding of the efficacy and safety of selective deep hypothermia and blood flow occlusion. PMID:26505410

  5. Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.

    Science.gov (United States)

    Guo, Zhen; Gong, Jianfeng; Li, Yi; Gu, Lili; Cao, Lei; Wang, Zhiming; Zhu, Weiming; Li, Jieshou

    2016-01-01

    MicroRNAs (miRNAs) have been shown to be important for the pathogenesis of Crohn's disease (CD). Exclusive enteral nutrition (EEN) is an effective therapy for inducing remission in CD. We aimed to investigate the alteration of miRNAs expression profile in the terminal ileal mucosa of CD patients before and after EEN. Twenty-five patients and ten healthy individuals were included. MiRNAs expression profile was firstly assessed using microarray technology and then validation was performed by qRT-PCR. The correlations between miRNAs and CD activity index (CDAI) score and serum C-reactive protein (CRP) level were also evaluated. Microarray analysis showed that mucosal miRNAs expression profile after EEN therapy was significantly changed compared with inflamed mucosa before treatment, and was most similar to the healthy one among all CD groups. Altered expressions of hsa-miR-192-5p, hsa-miR-423-3p, hsa-miR-99a-5p, hsa-miR-124-3p, hsa-miR-301a-5p, hsa-miR-495-5p, and hsa-let-7b-5p were confirmed by qRT-PCR. hsa-let-7b-5p was significantly correlated with serum CRP levels before and after EEN treatment (r = -0.518, p = 0.008, and r = -0.569, p = 0.003). Our study showed EEN induction therapy was associated with a trend for normalizing of the mucosal miRNAs expression profile, and expression of mucosal hsa-let-7b-5p was correlated with serum CRP level in patients with CD. PMID:27556489

  6. A comparative analysis of benthic nematode assemblages from Zostera noltii beds before and after a major vegetation collapse

    Science.gov (United States)

    Materatski, Patrick; Vafeiadou, Anna-Maria; Ribeiro, Rui; Moens, Tom; Adão, Helena

    2015-12-01

    Benthic nematodes are widely regarded as very suitable organisms to monitor potential ecological effects of natural and anthropogenic disturbances in aquatic ecosystems. During 2008, the seagrass beds of Zostera noltii located in the Mira estuary (SW Portugal) disappeared completely. However, during 2009, slight symptoms of natural recovery were observed, a process which has since evolved intermittently. This study aims to investigate changes in patterns of nematode density, diversity, and trophic composition between two distinct habitat conditions: "before" the collapse of seagrass beds, and during the early recovery "after" the seagrass habitat loss, through the analysis of: i) temporal and spatial distribution patterns of nematode communities, and ii) the most important environmental variables influencing the nematode assemblages. The following hypotheses were tested: i) there would be differences in nematode assemblage density, biodiversity and trophic composition during both ecological conditions, "before" and "after"; and ii) there would be differences in nematode assemblage density, biodiversity and trophic composition at different sampling occasions during both ecological conditions. Nematode density and diversity were significantly different between the two ecological situations. A higher density was recorded before, but a higher diversity was evident after the collapse of Z. noltii. In spite of the disturbance caused by the seagrass habitat loss in the Mira estuary, the nematode trophic composition did not significantly differ between the before and after seagrass collapse situations. Despite the significant differences found among sampling occasions, a consistent temporal pattern was not evident. The response of nematode communities following this extreme event exhibited considerable resistance and resilience to the new environmental conditions.

  7. CHANGES OF PLASMA ENDOTHELIN CONCENTRATIONS BEFORE AND AFTER PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY IN PATIENTS WITH MITRAL STENOSIS

    Institute of Scientific and Technical Information of China (English)

    尹瑞兴; 赵定菁; 朱树雄; 陶新智; 曾知恒; 夏树楹

    1996-01-01

    Plasma concentrations of endothalln in blood from the femoral vein and the antecnbital vein were measured in 35 patients with mitral stenosis and heart failure before and after percutaneous balloon mitral valvuloplasty(PBMV). The basal plasma concentrations of endothelin in blood from the antecubital vein inthe patients were significantly higher than those in 32 control subjects (15.40±3. 32 vs. 9.59±2.66 pg/ml, P<0. 001). Plasma endothefin concentrations in patients in New York Heart Asscclation functional classes Ⅱ and Ⅰ were significantly higher than thee in control subjects, spectiveiy. The concentrationsof endotheiin in patients with atrial fibrillation were also significantly higher than those in patients withnormal sinus rhythm. Ten to fifteen minutes after PBMV, plasma endothelin concentrations in blood (ramthe femoral vein significantly decreased from 16. 14±3.34 to 13. 74±3.78 pg/ml (P<0. 01). Seventy-two hours after the procedure, the concentrations of endothelin in blood from the antecnbital vein had fallen to 12. 31+2. 55 pg/ml (P<0. 001 vs. before PBMV and control subjects). Plasma endothelin concentrations still tended to be higher in patients with atrial fibrillation than those in normal sinus rhythm,but the difference did not reach statistlaal significance. There were ,Weak bnt signlficamly correlations of plasma endotbelin concentrations with the mean left atrial pressure (r= 0. 424, P<0. 001 ), mean right atrial pressure (r=0. 323, P<0. 01), mean transmittal pressure gradient (r=0. 397, P<0. 001), heart rate (r=0. 350,P<0. 005) and mitral valve area (r=-0. 454, P<0. 001) in the patients before and after PBMV.

  8. Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

    Science.gov (United States)

    Zhao, Cailei; Li, Yongxin; Cao, Weiguo; Xiang, Kui; Zhang, Heye; Yang, Jian; Gan, Yungen

    2016-01-01

    Abstract To explore the use of diffusion tensor imaging (DTI) parameters in the quantitative assessment of early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus. Ten patients with communicating hydrocephalus (age: 2–36 months) and 14 age-/gender-matched controls (age: 2–36 months) were enrolled in this study. All patients underwent the ventriculoperitoneal shunt procedure. The imaging data were collected before and 3 months after the operation. Regions of interests (ROIs) included the white matter near the frontal horn of the lateral ventricles (FHLV), the occipital horn of the lateral ventricles (OHLV), occipital subcortical (OS) area, frontal subcortical (FS) area, and thalamus. Fractional anisotropies (FA) and apparent diffusion coefficients (ADC) of the ROIs before and after ventriculoperitoneal shunt were compared between the patients and the controls. Three months after surgery, the patients recovered from the surgery with ameliorated intracranial pressure and slight improvement of clinical intelligence scale and motor scale. Before ventriculoperitoneal shunt, the FA values (except the right FHLV) were significantly decreased and the ADC values were significantly increased in the patients with hydrocephalus, compared with the controls. After the ventriculoperitoneal shunt, the FA values in the FHLV and OHLV of the patients were similar to the controls, but the FA values in other ROIs were still significantly lower than controls. The ADC values in the FS and OS white matter areas of the patients were similar to the controls; however, the ADC values in other ROIs were still significantly higher in patients. The increase of FA and the reduction in ADC in the ROIs preceded the clinical function improvement in patients with high intracranial pressure hydrocephalus and reflected the early changes in brain tissue microstructure, such as the compression of the white matter areas in

  9. Local recurrence of rectal cancer: MR imaging before and after oral superparamagnetic particles vs contrast-enhanced computed tomography

    International Nuclear Information System (INIS)

    The aim of this study was to compare three imaging strategies for the diagnosis of local recurrence of rectal cancer: (a) MR imaging; (b) MR imaging after administration of enteral superparamagnetic particles (Ferristene); and (c) contrast-enhanced CT. Seventeen patients with previous surgery for rectal cancer were examined, 12 patients with local tumour recurrence in the pelvis and 5 patients with postoperative changes. Pelvic multi-coil MR imaging before and after oral administration of superparamagnetic contrast medium [Abdoscan (Ferristene USAN), Nycomed-Amersham, Lidingoe, Sweden] as well as abdominal and pelvic CT was performed in all patients. The examinations were independently evaluated by three different radiologists. The general effect of the oral MR contrast medium, the delineation of normal and pathological structures as well as confidence in the diagnosis were registered on a visual analog scale (VAS). The diagnosis according to MR before and after oral contrast medium, and CT, was compared, in 16 patients, with the final diagnosis which was verified by biopsy (n = 3), surgery (n = 6), clinical follow-up (n = 4) and by follow-up with MR or CT (n = 3). No significant improvement in MR image quality was found after enteral contrast medium. The post-contrast MR diagnosis was not changed in any of the patients. The diagnosis on MR correlated with the final diagnosis in 12 of 16 patients (sensitivity 91 %, accuracy 62 %) and the diagnosis on CT in 11 of 16 patients (sensitivity 82 %, accuracy 56 %). The radiologists' ''confidence'' in the diagnosis and the degree of accordance with the final diagnosis did not score higher on MR after than before oral contrast administration; however, the accordance with the final diagnosis scored better on MR than on CT. No advantages of orally administered superparamagnetic contrast medium were observed in the examined patient group. Magnetic resonance is preferable to CT in diagnosing local tumour recurrence. (orig.)

  10. Evaluation of ductile-brittle transition temperature before and after neutron irradiation for RPV steels using small punch tests

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min-Chul [Korea Atomic Energy Research Institute, 150 Deokjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)]. E-mail: mckim@kaeri.re.kr; Oh, Yong Jun [Hanbat National University, Deogmyeong-dong, Yuseong-gu, Daejeon 305-719 (Korea, Republic of); Lee, Bong Sang [Korea Atomic Energy Research Institute, 150 Deokjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)

    2005-08-01

    Small punch (SP) tests were performed to evaluate the ductile-brittle transition temperature before and after a neutron irradiation of reactor pressure vessel (RPV) steels produced by different manufacturing (refining) processes. The results were compared to the standard transition temperature shifts from the conventional Charpy tests and the Master Curve fracture toughness tests in accordance with the American Society for Testing and Materials (ASTM) standard E1921. Small punch specimens were taken from a 1/4t location of the vessel thickness and machined into a 10 mm x 10 mm x 0.5 mm dimension. The specimens were irradiated in the research reactors at Korea Atomic Energy Research Institute Nuclear Research Institute in the Czech Republic at the different fluence levels of about 290 deg C. Small punch tests were performed in the temperature range of RT to -196 deg C using a 2.4 mm diameter ball. For the materials before and after irradiation, the small punch transition temperatures (T {sub SP}), which are determined at the middle of the upper small punch energies, showed a linear correlation with the Charpy index temperature, T {sub 41J}. T {sub SP} from the irradiated samples was increased with the fluence levels and was well within the deviation range of the unirradiated data. However, the transition temperature shift from the Charpy test ({delta}T {sub 41J}) shows a better correlation with the transition temperature shift ({delta}T {sub SP(E)}) when a specific small punch energy level rather than the middle energy level of the small punch curve is used to determine the transition temperature. T {sub SP} also had a correlation with the reference temperature (T {sub 0}) from the Master Curve method using a pre-cracked Charpy V-notched (PCVN) specimen.

  11. Correlation Analysis between Complex Relative Permittivity and Biochemical Components for Blood of Dialysis Patients before and after Hemodialysis

    Science.gov (United States)

    Takeda, Akira; Takata, Kazuyuki; Nagao, Hirotomo; Wang, Jianqing; Fujiwara, Osamu

    We previously measured for healthy subjects and patients who require hemodialysis the complex relative permittivity (εr´-jεr´´) of whole blood, and found that εr´-axis intercept εrt´ of straight line approximation to the Cole-Cole plots at frequencies from 200 MHz to 1GHz is significantly different with a level of less than 1% among its averaged values for healthy subjects and patients before and after dialysis, though any correlations between εrt´ and blood urea nitrogen (BUN) and creatinine being used as main indices for hemodialysis evaluation have not so far been clarified. In this study, to make correlation analyses between the intercept εrt´ and blood biochemical components for nine patients before and after hemodialysis, we measured six kinds of their blood components including BUN and creatinine, and calculated their Pearson product-moment correlation coefficients for εrt´ along with significant probability P based on a t-test. It should be noted that P is a reference probability to determine whether or not a null hypothesis can be rejected, and that the P value of 0.05 is commonly used as a significance level for statistical test. As a result, we found that a strong correlation with P 0.05 between εrt´ and other blood components including BUN and creatinine. Although albumin is not used as an index for hemodialysis efficiency, it can reflect water amount in blood vessels and liver operation. This finding implies that εrt´ could be used as an index for evaluating blood viscosity and liver function.

  12. Study on the change of hepatic fibrosis indicators in serum before and after I-131 treatment in Graves' Patients

    International Nuclear Information System (INIS)

    Full text: Objective: To explore the change of hepatic fibrosis indicators, i.e., PC-III (type III procollagen), IV-C (type IV collagen), HA (hyaluronic acid), LN (laminin) levels in serum of Graves' patients before and after I-131 treatment. Methods: Control group were 40 healthy cases (female 25, male 15, aged 18-60 years) with normal serum levels of those indicators by medical examination in our hospital. Fifty-five Graves' patients (female 32, male 23, aged 17-58) were diagnosed by thyroid function indicators (TT3, TT4, FT3, FT4, TSH) tests, thyroid iodine intake and clinical symptoms and signs, with normal hepatic function indicators and without combined history of hepatic disease, cardiac disease, diabetes, and rheumatic disease. Three to six months after I-131 treatment these were completely recovered (back to normal thyroid function, shrunken thyroid gland volume from swelling, and disappeared clinical symptoms and signs). In both controls and Graves' patients, 2 ml venous blood was taken at early morning from each case with limosis respectively before and after I- 131 treatment. RIA method was adopted for detection of each serum indicator with reagents kit. Data were analyzed by t test in the SPSS statistical software pack. Results: 1. In Graves' patients, before treatment PC- III (type III procollagen) levels were statistically higher than that in controls (p0.05). 2. In Graves' patients, PC-III significantly decreased to a lower level after treatment than before (p05). 3. In Graves' patients, after treatment there is no significant difference of indicator levels when compared with controls (p>0.05). Conclusion: Graves' patients had certain degree of hyperplasia of hepatic connective tissue, and this pathogenesis recovered with healing of Graves' disease. PC-III positive rate and thyroid function indicator positive rate may be better in accordance with the disease process than IV-C, Ha and LN indicators. These data showed that of four serum hepatic

  13. Persistent Aseismic Deformation in Central Japan Revealed by GPS Observation Before and After the 2011 Tohoku-Oki Earthquake

    Science.gov (United States)

    Meneses Gutierrez, A. D. V.; Sagiya, T.

    2015-12-01

    On March 11th, 2011 the occurrence of the Tohoku-oki Earthquake (Mw 9.0) considerably changed the observed crustal deformation pattern in Central -Eastern Japan, providing the opportunity to study the mechanical properties in the area, since elastic and inelastic mediums would have different response to the coseismic instantaneous displacement as well as transient postseismic displacement. In the near field of the 2011 Tohoku-oki earthquake, it is difficult to extract a pure deformation response since direct effects from the postseismic deformation source are mixed. In order to focus on the response at the far field, we analyzed postseismic crustal deformation in Central Japan. Before the quake, we observe general East-West contraction with localize deformation in the eastern margin of the Japan Sea, known as the Niigata Kobe Tectonic Zone (NKTZ) (Sagiya, 2000), whereas the coseismic response, which corresponds to the instantaneous elastic strain release, do not indicate highly concentrated strain feature, as expected if the deformation could be explain only by an elastic behavior. This implies that the interseismic and coseismic strains are not balanced and there is significant amount of contribution of inelastic processes. In the Earth's crust, inelastic processes are expected to take a form of aseismic faulting, and should be distinguished from elastic behavior by its spatial wavelength. Also, the inelastic behavior can be persistent before and after the quake since the coseismic stress change in the far field is considered to be too small to change the regional stress that drives the inelastic process. Thus we review temporal variation of crustal deformation pattern in Central Japan based on daily coordinates of 837 GPS sites from GEONET, before and after the Tohoku-oki earthquake in order to distinguish elastic and inelastic behavior within the NKTZ. We found that the deformation in the area can be explained as a combination of two processes: an elastic

  14. Knowledge, attitude and skills before and after a module on pharmaceutical promotion in a Nepalese medical school

    Directory of Open Access Journals (Sweden)

    Shankar P Ravi

    2012-01-01

    Full Text Available Abstract Background Pharmaceutical promotion is widespread and can impact prescribing by health professionals. Little research has been conducted on interactions between medical students and the pharmaceutical industry. Teaching about pharmaceutical promotion is inadequate. A survey showed that many schools spend only about two hours teaching this important topic while others spend around six hours. Recently a manual on understanding and responding to promotion has been published by Health Action International (HAI and the World Health Organization (WHO. From April to August 2011 the department of Clinical Pharmacology at KIST Medical College, Lalitpur, Nepal conducted a module on pharmaceutical promotion for second year students based on the manual. The module used active learning strategies such as brainstorming sessions, role plays and group activities. The study worked on the hypothesis that a module on pharmaceutical promotion will be effective in improving the knowledge, attitude and skills of medical students regarding pharmaceutical promotion. The impact of the module on knowledge, attitude and skills was tested using a retrospective-pre questionnaire. The scores according to gender and method of financing of medical education before and after the module were compared using appropriate non-parametric tests. Results Eighty-seven of the 100 second year students (87% participated in the study. 47 were females (54% and 39 (44.83% were males and one did not state the gender. Seventy-seven students (88.5% were self-financing while 9 were scholarship students. The median knowledge, attitude and skills score before the module were 9, 13 and 6 respectively while the overall score was 28. The scores increased significantly to 16, 15 and 14 respectively after the module while the overall score increased to 45. The median attitude scores and total scores were significantly higher among females both before and after the module. The scores did not

  15. Aerosol Physical and Chemical Properties Before and After the Manaus Plume in the GoAmazon2014 Experiment

    Science.gov (United States)

    Artaxo, P.; Barbosa, H. M.; Ferreira De Brito, J.; Wurm, F.; Holanda, B. A.; Carbone, S.; Arana, A.; Cirino, G. G.; Souza, R. A. F. D.; Rizzo, L. V.; Martin, S. T.; Andreae, M. O.; Holben, B. N.; Schafer, J.

    2014-12-01

    As part of the GoAmazon2014 experiment, several aerosol and trace gas monitoring stations are being operated for at least one year before and after the Manaus plume. Three sites are being operated in pristine conditions, with atmospheric properties under natural biogenic conditions. These three sites called T0 are: ATTO (Amazon Tall Tower Observatory), ZF2 ecological research site and a third site called EMBRAPA. After the air masses are exposed to the Manaus plume, one site (called T2) is being operated right on the opposite side of the Negro River under the direct influence of the Manaus plume at 5 Km downwind of Manaus. Finally, at about 150 Km downwind of Manaus is the T3 Manacapuru site. Aerosol chemical composition is being analyzed using filters for fine (PM2.5) and coarse mode aerosol as well as three Aerodyne ACSM (Aerosol Chemical Speciation Monitors) instruments. Aerosol absorption is being studied with several aethalometers and MAAP (Multi Angle Absorption Photometers). Aerosol light scattering are being measured at several wavelengths using nephelometers. Aerosol size distribution is determined using scanning mobility particle sizers. The aerosol column is measures using AERONET sunphotometers before and after the Manaus plume, as well as several Lidar systems. The three sites before the Manaus plume show remarkable similar variability in aerosol concentrations and optical properties. This pattern is very different at the T2 site, with large aerosol concentrations enhancing aerosol absorption and scattering significantly. The aerosol is very oxidized before being exposed to the Manaus plume, and this pattern changes significantly for T2 and T3 sites, with a much higher presence of less oxidized aerosol. Typical ozone concentrations at mid-day before Manaus plume is a low 10-12 ppb, value that changes to 50-70 ppb for air masses suffering the influence of Manaus plume. A detailed comparison of aerosol characteristics and composition for the several

  16. Emergency Department Visits for Homelessness or Inadequate Housing in New York City before and after Hurricane Sandy.

    Science.gov (United States)

    Doran, Kelly M; McCormack, Ryan P; Johns, Eileen L; Carr, Brendan G; Smith, Silas W; Goldfrank, Lewis R; Lee, David C

    2016-04-01

    Hurricane Sandy struck New York City on October 29, 2012, causing not only a large amount of physical damage, but also straining people's health and disrupting health care services throughout the city. In prior research, we determined that emergency department (ED) visits from the most vulnerable hurricane evacuation flood zones in New York City increased after Hurricane Sandy for several medical diagnoses, but also for the diagnosis of homelessness. In the current study, we aimed to further explore this increase in ED visits for homelessness after Hurricane Sandy's landfall. We performed an observational before-and-after study using an all-payer claims database of ED visits in New York City to compare the demographic characteristics, insurance status, geographic distribution, and health conditions of ED patients with a primary or secondary ICD-9 diagnosis of homelessness or inadequate housing in the first week after Hurricane Sandy's landfall versus the baseline weekly average in 2012 prior to Hurricane Sandy. We found statistically significant increases in ED visits for diagnosis codes of homelessness or inadequate housing in the week after Hurricane Sandy's landfall. Those accessing the ED for homelessness or inadequate housing were more often elderly and insured by Medicare after versus before the hurricane. Secondary diagnoses among those with a primary ED diagnosis of homelessness or inadequate housing also differed after versus before Hurricane Sandy. These observed differences in the demographic, insurance, and co-existing diagnosis profiles of those with an ED diagnosis of homelessness or inadequate housing before and after Hurricane Sandy suggest that a new population cohort-potentially including those who had lost their homes as a result of storm damage-was accessing the ED for homelessness or other housing issues after the hurricane. Emergency departments may serve important public health and disaster response roles after a hurricane, particularly for

  17. The patient safety culture as perceived by staff at two different emergency departments before and after introducing a flow-oriented working model with team triage and lean principles: a repeated cross-sectional study

    OpenAIRE

    Burström, Lena; Letterstal, Anna; Engström, Marie-Loise Walker; Berglund, Anders; Enlund, Mats

    2014-01-01

    Background: Patient safety is of the utmost importance in health care. The patient safety culture in an institution has great impact on patient safety. To enhance patient safety and to design strategies to reduce medical injuries, there is a current focus on measuring the patient safety culture. The aim of the present study was to describe the patient safety culture in an ED at two different hospitals before and after a Quality improvement (QI) project that was aimed to enhance patient safety...

  18. Effect of Novel, School-Based High-Intensity Interval Training (HIT) on Cardiometabolic Health in Adolescents: Project FFAB (Fun Fast Activity Blasts) - An Exploratory Controlled Before-And-After Trial

    OpenAIRE

    Weston, Kathryn L; Azevedo, Liane B.; Bock, Susan; Weston, Matthew; George, Keith P.; Batterham, Alan M.

    2016-01-01

    Background Low-volume high-intensity interval training holds promise for cardiometabolic health promotion in adolescents, but sustainable interventions must be practical and engaging. We examined the effect of a school-based multi-activity low-volume high-intensity interval training intervention on adolescents’ cardiometabolic health. Methods In an exploratory controlled before-and-after design, 101 adolescents (mean age ± standard deviation [SD] 14.0 ± 0.3 years) were recruited from four sch...

  19. Adsorption properties of ultradispersed powders of aluminum alloys with rare-earth metals, before and after water treatment

    Science.gov (United States)

    Ryabina, A. V.; Shevchenko, V. G.; Eselevich, D. A.

    2014-10-01

    Adsorption of nitrogen on Al-3% La, Al-1.5% Sc, and Al-3% Ce powders before and after processing with water in the relative pressure range p/p s = 10˜3 to 0.999 is experimentally studied at a temperature of 78 K. It is shown that the interaction between ultradispersed powder and water depends on the properties of the original powder, including the original content and composition of the oxide-hydroxide phases in the surface layers of metal particles, and the length and conditions of storage. Results confirming that processing powders containing rare-earth metals with water at room temperature leads to the formation of new phases and affects their morphology are presented. It is shown that the nanopores formed between crystallites on the surface of the particles during oxidation with water and subsequent thermal dehydration play an important role in the properties of powders processed with water. The specific surface and the porosity of powders are calculated.

  20. Characterization and photoluminescence studies of CdTe nanoparticles before and after transfer from liquid phase to polystyrene

    Indian Academy of Sciences (India)

    Shugang Wang; Yaoxian Li; Jie Bai; Qingbiao Yang; Yan Song; Chaoqun Zhang

    2009-10-01

    The major objective of this work was to detect the change of photoluminescence (PL) intensity of CdTe nanoparticles (NPs) before and after transfer from liquid phase to polystyrene (PS) matrix by electrospinning technique. Thio-stabilized CdTe NPs were first synthesized in aqueous, then enwrapped by cetyltrimethylammonium bromide (CTAB), and finally, transferred into PS matrix to form CdTe/PS nanofibres by electrospinning. Then, CdTe/PS nanofibres were characterized by scanning electron microscope (SEM) and transmission electron microscope (TEM) to observe their morphology and distribution, respectively. The selective area electronic diffraction (SAED) pattern proved that the CdTe NPs were cubic lattice. The PL spectrum indicated that CdTe NPs have been transferred into PS nanofibres, and the PL intensity of CdTe NPs in the nanofibres was even higher than that before CdTe NPs were introduced into PS nanofibres. Moreover, X-ray photoelectron spectra (XPS) revealed that thiol-stabilized CdTe NPs were enwrapped by CTAB, and PS acted as a dispersant in the process of electrospinning.

  1. Downstream migration of recently metamorphosed sea lampreys in the Ocqueoc River, Michigan, before and after treatment with lampricides

    Science.gov (United States)

    Hanson, Lee H.; Swink, William D.

    1989-01-01

    The objectives of this study were to determine the effectiveness ofchemical treatments of the Ocqueoc River, Michigan, in reducing the number of recently metamorphosed sea lampreys Petromyzon marinus migrating to Lake Huron and to estimate total numbers of migrants produced before and after treatment. Sea lampreys were captured during their downstream migration in a single fyke net fished in the same location from September 1963 through August 1975. The catch, which averaged 3,474 sea lampreys (range, 3,248-3,913) during four migration periods (September-June) before treatment in 1968, declined to 4 during the 1974-1975 migration period. Markrecapture studies were conducted to determine the capture efficiency of the net for recently metamorphosed sea lampreys and to estimate the total downstream migration for each migration period. Estimated downstream migrations before treatment averaged 62,036 sea lampreys (range, 58,000-69,875) for four migration periods and declined to 71 during the 1974-1975 migration period. Catches were usually greater in fall than in spring. The fall peak in migratory activity was in November or December, and the spring peak was in April; both peaks occurred while water levels were high and water temperatures were near 5A?C.

  2. Radiographic evaluation of elbow joints before and after surgery in dogs with possible fragmented medial coronoid process

    International Nuclear Information System (INIS)

    To determine the usefulness of 5 radiographic projections of the elbow joint for identification of fragmented coronoid process (FCP) and associated secondary degenerative changes in dogs. Longitudinal clinical study. 19 dogs suspected of having FCP (7 dogs, 1 elbow joint; 12 dogs, both elbow joints). 5 radiographic projections were obtained before and after surgery for all elbow joints on which exploratory arthrotomy was performed because of suspected FCP. Radiographs obtained before surgery were compared with radiographs obtained after surgery and radiographs taken of the excised fragments. Each projection was evalated for its utility in definitively identifying FCP and 7 specific degenerative changes. Interevaluator agreement, use of each radiographic projection for definitively identifying a feature, and ability of the 4 evaluators to definitively identify a feature were analyzed. The craniolateral-caudomedial oblique (Cr15L-CdMO) projection had a significantly higher sensitivity for definitively identifying FCP, compared with the other 4 projections. Interevaluator and kappa agreement for the 5 projections did not differ significantly among the 7 degenerative changes evaluated. The radiographic projection with the highest sensitivity and specificity for detection of a particular degenerative change varied by feature. Of the 5 radiographic projections evaluated, the Cr15L-CdMO projection provided the highest sensitivity and was the best projection to use for definitively identifying FCP. The craniocaudal, Cr15L-CdMO, and mediolateral projections most reliably allowed for identification of secondary degenerative changes

  3. Bone-marrow MR imaging before and after autologous marrow transplantation in lymphoma patients without known bone-marrow involvement

    International Nuclear Information System (INIS)

    Purpose: To study lumbar bone marrow by means of MR imaging before and after bone-marrow transplantation in lymphoma patients. Particular emphasis was paid to heterogeneity and to focal manifestations, i.e. appearances that could simulate tumor. Material and Methods: Twenty-two patients who were disease-free for a minimum of 30 months after transplantation were studied in 107 MR examinations. Two radiologists visually evaluated coronal T1-weighted and short inversion time inversion-recovery (STIR) images. Results: T1-weighted images demonstrated a more heterogeneous marrow after transplantation than before it. Sharply defined focal low signal intensity areas appeared on this sequence in 5 (23%) of the 22 patients at between 21 and 60 weeks after transplantation. The mean age of these 5 patients was 48.4 years (range 42-54 years). The difference in age between these 5 patients and the remaining 17 patients, who had a mean age of 33.4 years (range 14-51 years), was statistically significant (p<0.01, Student's t-test, 2-sided test). Conclusion: Sharply defined focal low signal intensity areas may be seen on T1-weighted images of bone marrow in patients who are in complete remission after transplantation, particularly in those aged over 40-45 years. (orig.)

  4. Self-assessment of facial form oral function and psychosocial function before and after orthognathic surgery: A retrospective study

    Directory of Open Access Journals (Sweden)

    Narayanan Vinod

    2008-01-01

    Full Text Available Orthognathic surgery is a well-accepted treatment for patients with skeletal discrepancies. The primary motivation of many patients who seek orthognathic surgery is esthetics and not for correction of functional disability. The treatment is incomplete if the surgeon attempts to correct the physical deformity alone without adequate understanding and regard for the emotional framework. The purpose of this study is aimed at patient′s self-perceptions of facial form oral function and psychosocial function before and after orthognathic surgery. Fifty patients were included in the study, of which 21 were used as control. Twenty-two questions were asked to evaluate the problem in all four areas as mentioned earlier. Each question takes a score from one to five. In group I, the internal consistency of each scale indicates moderate to high internal reliability, ranging from α = 0.71 for general health to α = 0.88 for psychosocial problem. In group II, except for functional problems, the internal consistency of each scale has moderate to high reliability. The psychological wellbeing of an orthognathic surgery patient is enhanced by careful preoperative counseling regarding the expected surgical treatment objectives, the operative course, and the expected postoperative sequelae. Patients who undergo orthognathic surgery readily accept the changes in their postoperative appearance and are satisfied with achieved results.

  5. General anaesthesia vs. conscious sedation for transfemoral aortic valve implantation: a single UK centre before-and-after study.

    Science.gov (United States)

    Miles, L F; Joshi, K R; Ogilvie, E H; Densem, C G; Klein, A A; O'Sullivan, M; Martinez, G; Sudarshan, C D; Abu-Omar, Y; Irons, J F

    2016-08-01

    Reported data suggest that 99% of transfemoral, transcatheter aortic valve implantations in the UK are performed under general anaesthesia. This before-and-after study is the first UK comparison of conscious sedation vs. general anaesthesia for this procedure. Patients who underwent general anaesthesia received tracheal intubation, positive pressure ventilation, radial arterial and central venous access and urinary catheterisation. Anaesthesia was maintained with propofol or sevoflurane. Patients who received conscious sedation had a fascia iliaca and ilioinguinal nerve block and low-dose remifentanil infusion, without invasive monitoring or urinary catheterisation. Recruitment took place between August 2012 and July 2015, with a 6-month crossover period between November 2013 and June 2014. A total of 88 patients were analysed, evenly divided between the two groups. Patients receiving conscious sedation had a shorter anaesthetic time (mean (SD) 121 (28) min vs. 145 (41) min; p < 0.001) and recovery room time (110 (50) min vs. 155 (48) min; p = 0.001), lower requirement for inotropes (4.6% vs 81.8%; OR (95% CI) 0.1 (0.002-0.050); p < 0.001) and a lower incidence of malignant dysrhythmia (0% vs 11.4%; p = 0.020). Conscious sedation appears a feasible alternative to general anaesthesia for this procedure and is associated with a reduced requirement for inotropic support and improved efficiency. PMID:27353456

  6. Probing the Structure and Chemistry of Perylenetetracarboxylic Dianhydride on Graphene Before and After Atomic Layer Deposition of Alumina.

    Science.gov (United States)

    Johns, James E; Karmel, Hunter J; Alaboson, Justice M P; Hersam, Mark C

    2012-07-11

    The superlative electronic properties of graphene suggest its use as the foundation of next generation integrated circuits. However, this application requires precise control of the interface between graphene and other materials, especially the metal oxides that are commonly used as gate dielectrics. Towards that end, organic seeding layers have been empirically shown to seed ultrathin dielectric growth on graphene via atomic layer deposition (ALD), although the underlying chemical mechanisms and structural details of the molecule/dielectric interface remain unknown. Here, confocal resonance Raman spectroscopy is employed to quantify the structure and chemistry of monolayers of 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) on graphene before and after deposition of alumina with the ALD precursors trimethyl aluminum (TMA) and water. Photoluminescence measurements provide further insight into the details of the growth mechanism, including the transition between layer-by-layer growth and island formation. Overall, these results reveal that PTCDA is not consumed during ALD, thereby preserving a well-defined and passivating organic interface between graphene and deposited dielectric thin films. PMID:22905282

  7. Relating Pneumococcal Carriage Among Children to Disease Rates Among Adults Before and After the Introduction of Conjugate Vaccines.

    Science.gov (United States)

    Weinberger, Daniel M; Grant, Lindsay R; Weatherholtz, Robert C; Warren, Joshua L; O'Brien, Katherine L; Hammitt, Laura L

    2016-06-01

    The use of pneumococcal conjugate vaccines (PCVs) in children has a strong indirect effect on disease rates in adults. When children are vaccinated with PCVs, other serotypes that are not targeted by the vaccine can increase in frequency (serotype replacement) and reduce the direct and indirect benefits of the vaccine. To understand and predict the likely impacts of serotype replacement, it is important to know how patterns in the transmission of serotypes among children relate to disease rates in adults. We used data on pneumococcal carriage and disease from Navajo Nation children and adults collected before and after the routine use of PCVs (1998-2012). Using regression models within a Bayesian framework, we found that serotype-specific carriage and invasiveness (disease incidence divided by carriage prevalence) had similar patterns in children and adults. Moreover, carriage in children, invasiveness in children, and a serotype-specific random intercept (which captured additional variation associated with the serotypes) could predict the incidence serotype-specific pneumococcal disease in adults 18-39 years of age and those 40 years of age or older in the era of routine use of PCVs. These models could help us predict the effects of future pneumococcal vaccine use in children on disease rates in adults, and the modeling approach developed here could be used to test these findings in other settings. PMID:27188949

  8. Microstructural morphology of the semi-solid high carbon steel T12 before and after rheo-rolling

    Institute of Scientific and Technical Information of China (English)

    Jiguang Li; Yonglin Kang; Aimin Zhao; Yi Sun; Man Cheng

    2005-01-01

    The semi-solid high carbon steel T12 was rolled in a closed box groove under a certain condition by the rheo-rolling equipment, and the microstructural morphology of the semi-solid T12 before and after deformation was investigated by optical microscope to analyze and summarize the microstructure evolution law of T12 deformed in semi-solid state. The experiment results show that the grain shape before deformation of the semi-solid T12 steel displays globule or ellipse by the electromagnetic stirring,the distribution of solid and liquid phases is homogeneous. But the microstructure of semi-solid product after rheo-rolling exhibits macrosegregation that the distribution of liquid and solid phases changes, the liquid phases divorce from the solid phases. In the transverse section, most of the solid phases get together in the center of the specimen, the liquid phases flow to the surface or the edge of the specimen, and the grains occur plastic deformation while reduction increased. In longitudinal section, the middle microstructure of the specimen is more homogeneous than that at the head or tail, the head microstructure is similar to the tail and the size of the grains is not homogeneous.

  9. Tobacco control policies in hospitals before and after the implementation of a national smoking ban in Catalonia, Spain

    Directory of Open Access Journals (Sweden)

    Puig Montse

    2009-05-01

    Full Text Available Abstract Background Diverse projects and guidelines to assist hospitals towards the attainment of comprehensive smoke-free policies have been developed. In 2006, Spain government passed a new smoking ban that reinforce tobacco control policies and banned completely smoking in hospitals. This study assesses the progression of tobacco control policies in the Catalan Network of Smoke-free Hospitals before and after a comprehensive national smoking ban. Methods We used the Self-Audit Questionnaire of the European Network for Smoke-free Hospitals to score the compliance of 9 policy standards (global score = 102. We used two cross-sectional surveys to evaluate tobacco control policies before (2005 and after the implementation of a national smoking ban (2007 in 32 hospitals of Catalonia, Spain. We compared the means of the overall score in 2005 and 2007 according to the type of hospital, the number of beds, the prevalence of tobacco consumption, and the number of years as a smoke-free hospital. Results The mean of the implementation score of tobacco control policies was 52.4 (95% CI: 45.4–59.5 in 2005 and 71.6 (95% CI: 67.0–76.2 in 2007 with an increase of 36.7% (p 300 beds (41.1% increase; p Conclusion The national smoking ban appears to increase tobacco control activities in hospitals combined with other non-bylaw initiatives such as the Smoke-free Hospital Network.

  10. Diagnostic accuracy of short-time inversion recovery sequence in Graves' ophthalmopathy before and after prednisone treatment

    Energy Technology Data Exchange (ETDEWEB)

    Tortora, Fabio; Belfiore, Maria Paola; Romano, Francesco; Cappabianca, Salvatore; Cirillo, Sossio [' ' F. Magrassi-A. Lanzara' ' Second University, Naples (Italy). Dept. of Clinical and Experimental Medicine and Surgery; Prudente, Mariaevelina [Second University, Naples (Italy). Medicine Dept.; Vita Salute San Raffaele Univ., Milan (Italy). Dept. of Neuroradiology; Cirillo, Mario [Second University, Naples (Italy). Neuroradiological Services; Elefante, Andrea [Federic II Univ., Naples (Italy). Neuroradilogical Dept.; Carella, Carlo [Polidiagnostic Center Check-Up, Salerno (Italy)

    2014-05-15

    In Graves' Ophthalmopathy, it is important to distinguish active inflammatory phase, responsive to immunosuppressive treatment, from fibrotic unresponsive inactive one. The purpose of this study is, first, to identify the relevant orbital magnetic resonance imaging signal intensities before treatment, so to classify patients according to their clinical activity score (CAS), discriminating inactive (CAS < 3) from active Graves' Ophthalmopathy (GO) (CAS > 3) subjects and, second, to follow post-steroid treatment disease. An observational study was executed on 32 GO consecutive patients in different phases of disease, based on clinical and orbital Magnetic Resonance Imaging parameters, compared to 32 healthy volunteers. Orbital Magnetic Resonance Imaging was performed on a 1.5 tesla Magnetic Resonance Unit by an experienced neuroradiologist blinded to the clinical examinations. In pre-therapy patients, compared to controls, a medial rectus muscle statistically significant signal intensity ratio (SIR) in short-time inversion recovery (STIR) (long TR/TE) sequence was found, as well as when comparing patients before and after treatment, both medial and inferior rectus muscle SIR resulted significantly statistically different in STIR. These increased outcomes explain the inflammation oedematous phase of disease, moreover after steroid administration, compared to controls; patients presented lack of that statistically significant difference, thus suggesting treatment effectiveness. In our study, we proved STIR signal intensities increase in inflammation oedematous phase, confirming STIR sequence to define active phase of disease with more sensibility and reproducibility than CAS alone and to evaluate post-therapy involvement. (orig.)

  11. Cognitive functions in adults with β-thalassemia major: before and after blood transfusion and comparison with healthy controls.

    Science.gov (United States)

    Raz, Sivan; Koren, Ariel; Dan, Orrie; Levin, Carina

    2016-07-01

    While β-thalassemia major (β-TM)-related physiological complications have been well established, less is known about implications for neuropsychological and cognitive function. The few existing studies have focused almost exclusively on children. We evaluated cognitive function in adult β-TM patients compared to healthy controls (study 1) and in β-TM patients before and after blood transfusion (study 2). Performance intelligence quotient (IQ) was evaluated with four subtests from the Wechsler Adult Intelligence Scale (WAIS-III). Attention functions were evaluated using the online continuous performance test (OCPT). The results of study 1 revealed poorer performance of β-TM patients on three of the four intelligence subtests, with significantly lower total performance IQ scores compared with controls. The percentage of participants with abnormal performance IQ (<85) was almost five times higher in the β-TM group (58%) than in the control group (12%). In study 2, significant differences were found in OCPT performance as a function of blood transfusion. Before transfusion, patients had higher rates of omission and commission errors, slower response times (RTs), and lower RT consistency than after transfusion. As β-TM patients' life expectancy is increasing, assessment and treatment of neurocognitive functions should become an integral part of appropriate follow-up to improve patients' quality of life. PMID:27447535

  12. Ventricular repolarization before and after treatment in patients with secondary hypertension due to renal-artery stenosis and primary aldosteronism.

    Science.gov (United States)

    Maule, Simona; Bertello, Chiara; Rabbia, Franco; Milan, Alberto; Mulatero, Paolo; Milazzo, Valeria; Papotti, Grazia; Veglio, Franco

    2011-10-01

    A prolonged QT interval is a risk factor for ischemic heart disease in hypertensive subjects. Patients with renal-artery stenosis and primary aldosteronism (PA) are at increased risk of cardiovascular events. The objective of the present study was to evaluate the QT interval in patients with renovascular hypertension (RV) and PA before and after treatment. A total of 24 patients with RV and 38 with PA were studied; 89 patients with essential hypertension (EH) served as control group. Corrected QT intervals (QTcH) were measured from a 12-lead ECG. Basal QTcH was longer in RV (429±30 ms) and PA (423±23 ms) compared with EH controls (407±18 ms; P440 ms was higher in RV (29%) and PA patients (29%) compared with EH controls (4%; P<0.001). QTcH interval was evaluated after treatment in 19 RV and 15 PA patients. QTcH was reduced after renal-artery angioplasty in RV patients (419±14 ms; P=0.02), and after spironolactone or adrenalectomy in PA (403±12 ms; P=0.01). In conclusion, QT interval was prolonged in patients with RV and PA compared with controls with EH. After angioplasty of renal-artery stenosis in RV, and treatment with spironolactone or adrenalectomy in PA, the cardiovascular risk of such patients may be reduced by concomitant blood pressure lowering and QT duration shortening. PMID:21677661

  13. Cine-MR imaging aqueductal CSF flow in normal pressure hydrocephalus syndrome before and after CSF shunt

    International Nuclear Information System (INIS)

    Reproducibility of the aqueductal CSF signal intensity on a gradient echo cine-MR sequence exploiting through plane inflow enhancement was tested in 11 patients with normal or dilated ventricles. Seven patients with normal pressure hydrocephalus (NPH) syndrome were investigated with the sequence before and after CSF shunting. Two patients exhibiting central flow void within a hyperintense aqueductal CSF improved after surgery and the flow void disappeared after shunting. One patient with increased maximum and minimum aqueductal CSF signal as compared to 18 healthy controls also improved and the aqueductal CSF signal was considerably decreased after shunting. Three patients with aqueductal CSF values similar to those in the controls did not improve, notwithstanding their maximum aqueductal CSF signals decreasing slightly after shunting. No appreciable aqueductal CSF flow related enhancement consistent with non-communicating hydrocephalus was found in the last NPH patient who improved after surgery. Cine-MR with inflow technique yields a reproducible evaluation of flow-related aqueductal CSF signal changes which might help in identifying shunt responsive NPH patients. These are likely to be those with hyperdynamic aqueductal CSF or aqueductal obstruction. (orig.)

  14. The Numerical Study of the Hemodynamic Characteristics in the Patient-Specific Intracranial Aneurysms before and after Surgery

    Science.gov (United States)

    Byun, Jun Soo; Choi, Sun-Young

    2016-01-01

    The patient-specific pre- and postsurgery cerebral arterial geometries in the study were reconstructed from computed tomography angiography (CTA). Three-dimensional computational fluid dynamics models were used to investigate the hemodynamic phenomena in the cerebral arteries before and after surgery of the aneurysm under realistic conditions. CFD simulations for laminar flow of incompressible Newtonian fluid were conducted by using commercial software, ANSYS v15, with the rigid vascular wall assumption. The study found that the flow patterns with the complex vortical structures inside the aneurysm were similar. We also found that the inflow jet streams were coming strongly in aneurysm sac in the presurgery models, while the flow patterns in postsurgery models were quite different from those in presurgery models. The average wall shear stress after surgery for model 1 was approximately three times greater than that before surgery, while it was about twenty times greater for model 2. The area of low WSS in the daughter saccular aneurysm region in model 2 is associated with aneurysm rupture. Thus the distribution of WSS in aneurysm region provides useful prediction for the risk of aneurysm rupture. PMID:27274764

  15. Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects before and after Drastic Weight Loss

    Science.gov (United States)

    Kim, Min-Ji; Marchand, Philippe; Henegar, Corneliu; Antignac, Jean-Philippe; Alili, Rohia; Poitou, Christine; Bouillot, Jean-Luc; Basdevant, Arnaud; Le Bizec, Bruno; Barouki, Robert; Clément, Karine

    2011-01-01

    Background In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. Objectives We characterized POP total body burden and their redistribution in obese individuals before and after drastic weight loss and compared these values with a variety of molecular, biological, and clinical parameters. Methods Seventy-one obese subjects were enrolled and underwent bariatric surgery. Blood and adipose tissue samples were obtained at different times from these individuals as well as from 18 lean women. Results POP content (17 dioxins/furans and 18 polychlorinated biphenyl congeners) in different adipose tissue territories was similar, allowing us to assess total POP body burden from a single biopsy. Total POP body burden was 2 to 3 times higher in obese than in lean individuals. We also found increased expression of some POP target genes in obese adipose tissue. Drastic weight loss led to increased serum POPs and, within 6–12 months, to a significant 15% decrease in total polychlorinated biphenyl body burden. Importantly, serum POP levels were positively correlated with liver toxicity markers and lipid parameters, independently of age and body mass index. Conclusions POP content in adipose tissue and serum correlate with biological markers of obesity-related dysfunctions. Drastic weight loss leads to a redistribution of POPs and to a moderate decrease of their total body burden. PMID:21156398

  16. Thin-section computed tomography findings before and after azithromycin treatment of neutrophilic reversible lung allograft dysfunction

    Energy Technology Data Exchange (ETDEWEB)

    Jong, Pim A. de [Department of Radiology, Katholieke Universiteit Leuven, Leuven (Belgium); Lung Transplantation Unit, Katholieke Universiteit Leuven, Leuven (Belgium); University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Vos, Robin; Verleden, Geert M.; Vanaudenaerde, Bart M. [Lung Transplantation Unit, Katholieke Universiteit Leuven, Leuven (Belgium); Verschakelen, Johny A. [Department of Radiology, Katholieke Universiteit Leuven, Leuven (Belgium)

    2011-12-15

    Recently a novel subgroup of bronchiolitis obliterans syndrome (BOS) has been described in patients after lung transplantation with high neutrophil counts in broncho-alveolar lavage and recovery of lung functional decline with azithromycin treatment. We aimed to describe the thin-section computed tomography (CT) findings of these neutrophilic reversible allograft dysfunction (NRAD) patients before and after azithromycin. A cohort of 100 lung transplant recipients with BOS were treated with azithromycin and underwent lung function testing, broncho-alveolar lavage and CT before azithromycin treatment and during follow-up. The 200 CT data sets were scored for bronchial dilatation, mucus plugging, centrilobular abnormalities, airway wall thickening, consolidation, ground glass and end-expiratory air trapping. NRAD was characterized by more centrilobular abnormalities on CT (p = 0.03 for prevalence and p = 0.06 for severity) compared to non-responders. At follow-up NRAD patients showed improvement in all CT abnormalities including air trapping, but the degree of improvement in all CT abnormalities was significantly different between responders and non-responders (who showed progression of bronchus dilatation, consolidation and air trapping). Within BOS patients those with NRAD differ from azithromycin non-responders by more centrilobular abnormalities on CT before azithromycin and improvement in bronchus dilatation, consolidation and air trapping during treatment. (orig.)

  17. Tracheomalacia before and after aortosternopexy: dynamic and quantitative assessment by electron-beam computed tomography with clinical correlation

    Energy Technology Data Exchange (ETDEWEB)

    Kao, S.C.S. [Dept. of Radiology, The Univ. of Iowa Coll. of Medicine, Iowa City, IA (United States); Kimura, K. [Dept. of Surgery, The Univ. of Iowa Coll. of Medinice, Iowa City, IA (United States); Smith, W.L. [Dept. of Radiology, The Univ. of Iowa Coll. of Medicine, Iowa City, IA (United States); Sato, Y. [Dept. of Radiology, The Univ. of Iowa Coll. of Medicine, Iowa City, IA (United States)

    1995-11-01

    To correlate the dynamics of tracheal collapse with clinical upper airway obstruction before and after aortosternopexy, seven boys and three girls (mean age, 10 months) underwent dynamic evaluation of the trachea by electron-beam computed tomography (EBCT). The site, extent, and severity of collapse were correlated with symptomatology and details of operative procedure. When >50% area collapse was used as the criterion for tracheomalacia, segmental involvement occurred above the aortic arch in all patients, extending to the aortic arch level in only four. Tracheomalacia involved two or fewer 8-mm levels in seven patients and more than two levels in three. Eight patients underwent one aortosternopexy procedure, resulting in clinical improvement in six and correlating well with EBCT findings. Of the remaining two patients who had single aortosternopexy and did not show clinical and radiographic improvement, one required operative repair of a vascular ring and the other continued to have recurrent respiratory tract infections. On the basis of EBCT findings, two patients required additional innominate arteriopexies: One improved, and the other remained symptomatic, requiring tracheostomy. EBCT is a noninvasive modality that allows preoperative diagnosis of tracheomalacia. More importantly, the operative decision and technique are guided by an objective and quantitative assessment of tracheal collapse. (orig.)

  18. Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment

    Institute of Scientific and Technical Information of China (English)

    Cha-Ze Lee; Hsuan-Shu Lee; Guan-Tarn Huang; Pei-Ming Yang; Jin-Chuan Sheu

    2006-01-01

    AIM: To develop a PCR assay using mutant-specific primers to detect mutation of tyrosine-methionineaspartate-aspartate (YMDD) motif of HBV to tyrosinevaline-aspartate-aspartate (YVDD) or tyrosine-isoleucineaspartate-aspartate (YIDD).METHODS: Cloned wild-type and mutant HBV sequences were used as templates to test the sensitivity and specificity of the assay. A variety of primer construction, primer concentration, dNTP concentration,and annealing temperature of primers were systematically examined. Pair primers specific to rtL180M and rtM204V were selected for YVDD detection. Primer specific to rtM204I with an additional 3'-penultimate base mismatched to both the mutant and wild-type sequence was selected for YIDD detection. We applied this assay to study YMDD mutants in 28 chronic hepatitis B patients before and after lamivudine treatment.RESULTS: We could detect as little as 0.001%-0.00001%of mutant viruses coexisting in 108-109 copies of wildtype HBV using this assay. YMDD mutants were detected in 8 of 12 HBeAg-positive patients and 8 of 16 HBeAgnegative patients before lamivudine treatment. After treatment, two more patients in HBeAg-positive patients and seven more patients in HBeAg-negative patients developed YMDD mutations.CONCLUSION: We developed a highly sensitive and specific assay for detecting YMDD mutants. This assay can be applied to monitor chronic hepatitis B patients before and during lamivudine treatment.

  19. Single photon emission computed tomography before and after treatment of anxiety using a selective serotonin reuptake inhibitor

    International Nuclear Information System (INIS)

    Background: The selective serotonin reuptake inhibitors (SSRIs) are currently recommended as first line medications for a number of different anxiety disorders, including obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and social anxiety disorder (social phobia) (SAD). This raises the question of what effects these agents have on the functional neuroanatomy of anxiety disorders. Methods: Single photon emission computed tomography (SPECT) brain scanning was undertaken in patients with OCD, PTSD, and SAD before and after treatment with citalopram, the most selective of the SSRIs. Statistical parametric mapping (SPM) was used to compare scans (pre- vs post-medication, and responders vs nonresponders) in the combined group of subjects. Results: Citalopram pharmacotherapy resulted in significant deactivation within anterior and superior cingulate and left hippocampus. Deactivation within the anterior cingulate, left paracingular cortex, and right inferior frontal cortex was more marked in treatment responders. Baseline activation did not, however, predict response to pharmacotherapy. Conclusion: Although each of the anxiety disorders may be mediated by different neurocircuits, there are some overlaps in the functional neuroanatomy of their response to SSRI treatment. The current data is consistent with previous work demonstrating the importance of limbic circuits in this spectrum of disorders. These play a crucial role in cognitive-affective processing, and are innervated by serotonergic neurons

  20. Lipid peroxidation and nitric oxide metabolites in sedentary subjects and sportsmen before and after a cardiopulmonary test.

    Science.gov (United States)

    Lo Presti, Rosalia; Canino, Baldassare; Montana, Maria; Caimi, Gregorio

    2013-01-01

    Our aim was to investigate the effects of an exercise test on some indices of oxidative status and endothelial function, in trained and untrained subjects. We examined lipid peroxidation, nitric oxide metabolites (NOx) and their ratio before and after a cardiopulmonary test, using a cycloergometer. We enrolled 60 male subjects who practiced sport unprofessionally, subdivided in two groups (A and B) according to the values of VO2max. Group A included sportsmen with poor or fair aerobic fitness (VO2max 39 ml/Kg/min). The control group included 19 male sedentary subjects. Lipid peroxidation was evaluated by detection of the thiobarbituric acid-reactive substances (TBARS); the NOx were evaluated employing the Griess reagent. At rest, in comparison with sedentary controls, an increase in TBARS, NOx and TBARS/NOx ratio was found in all sportsmen and partially in the two groups. After the cardiopulmonary test, the increase of TBARS and TBARS/NOx ratio was significantly more evident in sedentary controls than in sportsmen. No variation was observed for NOx in any group. These data suggest that sportsmen are protected against the acute oxidative stress induced by an exercise test, and that protection is not strictly dependent on the aerobic fitness. PMID:22710809

  1. Cine-MR imaging aqueductal CSF flow in normal pressure hydrocephalus syndrome before and after CSF shunt

    Energy Technology Data Exchange (ETDEWEB)

    Mascalchi, M. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Arnetoli, G. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Inzitari, D. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Dal Pozzo, G. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Lolli, F. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Caramella, D. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy)); Bartolozzi, C. (Sezione di Radiodiagnostica, Dipt. di Fisiopatologia Clinica, and Dipt. di Scienze Neurologiche, Florence Univ. (Italy))

    1993-11-01

    Reproducibility of the aqueductal CSF signal intensity on a gradient echo cine-MR sequence exploiting through plane inflow enhancement was tested in 11 patients with normal or dilated ventricles. Seven patients with normal pressure hydrocephalus (NPH) syndrome were investigated with the sequence before and after CSF shunting. Two patients exhibiting central flow void within a hyperintense aqueductal CSF improved after surgery and the flow void disappeared after shunting. One patient with increased maximum and minimum aqueductal CSF signal as compared to 18 healthy controls also improved and the aqueductal CSF signal was considerably decreased after shunting. Three patients with aqueductal CSF values similar to those in the controls did not improve, notwithstanding their maximum aqueductal CSF signals decreasing slightly after shunting. No appreciable aqueductal CSF flow related enhancement consistent with non-communicating hydrocephalus was found in the last NPH patient who improved after surgery. Cine-MR with inflow technique yields a reproducible evaluation of flow-related aqueductal CSF signal changes which might help in identifying shunt responsive NPH patients. These are likely to be those with hyperdynamic aqueductal CSF or aqueductal obstruction. (orig.).

  2. Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine.

    Directory of Open Access Journals (Sweden)

    Silvio D Brugger

    Full Text Available BACKGROUND: Simultaneous carriage of more than one strain of Streptococcus pneumoniae promotes horizontal gene transfer events and may lead to capsule switch and acquisition of antibiotic resistance. We studied the epidemiology of cocolonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal vaccine (PCV7. METHODOLOGY: Nasopharyngeal swabs (n 1120 were collected from outpatients between 2004 and 2009 within an ongoing nationwide surveillance program. Cocolonization was detected directly from swabs by restriction fragment length polymorphism (RFLP analysis. Serotypes were identified by agglutination, multiplex PCR and microarray. PRINCIPAL FINDINGS: Rate of multiple colonization remained stable up to three years after PCV7 introduction. Cocolonization was associated with serotypes of low carriage prevalence in the prevaccine era. Pneumococcal colonization density was higher in cocolonized samples and cocolonizing strains were present in a balanced ratio (median 1.38. Other characteristics of cocolonization were a higher frequency at young age, but no association with recurrent acute otitis media, recent antibiotic exposure, day care usage and PCV7 vaccination status. CONCLUSIONS: Pneumococcal cocolonization is dominated by serotypes of low carriage prevalence in the prevaccine era, which coexist in the nasopharynx. Emergence of such previously rare serotypes under vaccine selection pressure may promote cocolonization in the future.

  3. Salivary cortisol and testosterone responses to high-intensity cycling before and after an 11-day intensified training period.

    Science.gov (United States)

    Hough, John; Corney, Robert; Kouris, Antonios; Gleeson, Michael

    2013-01-01

    This study examined salivary cortisol and testosterone responses to two, different high-intensity, ∼30-min cycles separated by 2 h rest before and after an 11-day intensified training period. Twelve recreationally active, healthy males completed the study. Saliva samples were collected before, immediately after and 30 min after both bouts with salivary cortisol and testosterone concentrations assessed. Compared with pre-training blunted exercise-induced salivary cortisol, testosterone and cortisol/testosterone responses to both bouts post-training were observed (P cortisol, testosterone and cortisol/testosterone decreased from 11.1 to 3.1 and 7.0 to 4.4 nmol · L⁻¹ (cortisol), from 407 to 258 and from 473 to 274 pmol · L⁻¹ (testosterone) and from 12 to 4 and 7 to 5 (cortisol/testosterone) for the first and second bouts, respectively (P 0.05). Fatigue and Burnout scores were higher post- compared with pre-training (P cortisol and testosterone responses suggestive of increased fatigue.

  4. Isotopic composition of atmospheric water vapor before and after the monsoon's end in the Nagqu River Basin

    Institute of Scientific and Technical Information of China (English)

    YU Wusheng; YAO Tandong; TIAN Lide; WANG Yu; YIN Changliang

    2005-01-01

    Atmospheric water vapor samples were collected in the Nagqu River Basin in the middle of Tibetan Plateau between August and October in 2004. Results show that there exist some fluctuations of the δ18O of atmospheric water vapor, especially before and after the monsoon's end. Moreover, the variety trend of the δ 18O of atmospheric water vapor inverse correlates with that of dew point. Precipitation events make an important effect upon the variation of δ18O of atmospheric water vapor. During the whole sampling period, the δ18O values of atmospheric water vapor are low while precipitation events occurred. The moisture origins also contribute to the variation of δ18O of atmospheric water vapor. The oceanic moisture transported by the southwest monsoon results in lower δ18O of atmospheric water vapor in the Nagqu River Basin. Compared with the influence of the oceanic moisture, the δ18O values, however, appear high resulting from the effect of the continental air mass in this region.

  5. THE ROLE OF LIPOTROPIC THERAPY IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE BEFORE AND AFTER CORONARY REVASCULARIZATION

    Directory of Open Access Journals (Sweden)

    R. N. Adzhiev

    2013-01-01

    Full Text Available Review of large of trials that prove the positive impact of high-dose lipid-lowering therapy on the prognosis in patients with ischemic heart disease (IHD are presented. The data on the efficacy of the lipid profile correction by lipid apheresis in patients with hypercholesterolemia that is refractory to optimal medical therapy are showed. The results of the large trials (LIPS, ARMYDA, NAPLES II, ARMYDA-RECAPTURE, Post-CABG, TNT and meta-analyzes on the role of statins, prescribed before and after coronary artery bypass surgery and stenting, in reducing the risk of early and late cardiac events and the need for repeat myocardial revascularization are analyzed. The issue of therapeutic apheresis should be considered in cases of refractory hypercholesterolemia according to ESC/EAS Guidelines for the management of dyslipidaemias (2011. The tendency to reduction in the risk of stent restenosis and vein graft lesions after lipid apheresis is found in very high risk patients with IHD and refractory hypercholesterolemia that underwent coronary stenting or bypass surgery.

  6. THE ROLE OF LIPOTROPIC THERAPY IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE BEFORE AND AFTER CORONARY REVASCULARIZATION

    Directory of Open Access Journals (Sweden)

    R. N. Adzhiev

    2015-09-01

    Full Text Available Review of large of trials that prove the positive impact of high-dose lipid-lowering therapy on the prognosis in patients with ischemic heart disease (IHD are presented. The data on the efficacy of the lipid profile correction by lipid apheresis in patients with hypercholesterolemia that is refractory to optimal medical therapy are showed. The results of the large trials (LIPS, ARMYDA, NAPLES II, ARMYDA-RECAPTURE, Post-CABG, TNT and meta-analyzes on the role of statins, prescribed before and after coronary artery bypass surgery and stenting, in reducing the risk of early and late cardiac events and the need for repeat myocardial revascularization are analyzed. The issue of therapeutic apheresis should be considered in cases of refractory hypercholesterolemia according to ESC/EAS Guidelines for the management of dyslipidaemias (2011. The tendency to reduction in the risk of stent restenosis and vein graft lesions after lipid apheresis is found in very high risk patients with IHD and refractory hypercholesterolemia that underwent coronary stenting or bypass surgery.

  7. Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder.

    Science.gov (United States)

    Kujawa, Autumn; Weinberg, Anna; Bunford, Nora; Fitzgerald, Kate D; Hanna, Gregory L; Monk, Christopher S; Kennedy, Amy E; Klumpp, Heide; Hajcak, Greg; Phan, K Luan

    2016-11-01

    Increased error monitoring, as measured by the error-related negativity (ERN), has been shown to persist after treatment for obsessive-compulsive disorder in youth and adults; however, no previous studies have examined the ERN following treatment for related anxiety disorders. We used a flanker task to elicit the ERN in 28 youth and young adults (8-26years old) with primary diagnoses of generalized anxiety disorder (GAD) or social anxiety disorder (SAD) and 35 healthy controls. Patients were assessed before and after treatment with cognitive-behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRI), and healthy controls were assessed at a comparable interval. The ERN increased across assessments in the combined sample. Patients with SAD exhibited an enhanced ERN relative to healthy controls prior to and following treatment, even when analyses were limited to SAD patients who responded to treatment. Patients with GAD did not significantly differ from healthy controls at either assessment. Results provide preliminary evidence that enhanced error monitoring persists following treatment for SAD in youth and young adults, and support conceptualizations of increased error monitoring as a trait-like vulnerability that may contribute to risk for recurrence and impaired functioning later in life. Future work is needed to further evaluate the ERN in GAD across development, including whether an enhanced ERN develops in adulthood or is most apparent when worries focus on internal sources of threat. PMID:27495356

  8. Do prevailing societal models influence reports of near-death experiences?: a comparison of accounts reported before and after 1975.

    Science.gov (United States)

    Athappilly, Geena K; Greyson, Bruce; Stevenson, Ian

    2006-03-01

    Transcendental near-death experiences show some cross-cultural variation that suggests they may be influenced by societal beliefs. The prevailing Western model of near-death experiences was defined by Moody's description of the phenomenon in 1975. To explore the influence of this cultural model, we compared near-death experience accounts collected before and after 1975. We compared the frequency of 15 phenomenological features Moody defined as characteristic of near-death experiences in 24 accounts collected before 1975 and in 24 more recent accounts matched on relevant demographic and situational variables. Near-death experience accounts collected after 1975 differed from those collected earlier only in increased frequency of tunnel phenomena, which other research has suggested may not be integral to the experience, and not in any of the remaining 14 features defined by Moody as characteristic of near-death experiences. These data challenge the hypothesis that near-death experience accounts are substantially influenced by prevailing cultural models.

  9. Opioid consumption before and after the establishment of a palliative medicine unit in an Egyptian cancer centre.

    Science.gov (United States)

    Alsirafy, Samy A; Ibrahim, Noha Y; Abou-Elela, Enas N

    2012-01-01

    Opioid consumption before and after the establishment of a palliative medicine unit (PMU) in an Egyptian cancer centre was reviewed. A comparison of consumption during the year before the PMU was established to consumption during the third year after the PMU's establishment revealed that morphine consumption increased by 698 percent, fentanyl by 217 percent, and tramadol by 230 percent. Expressed in defined daily dose (DDD) and adjusted for 1,000 new cancer patients, consumption increased by 460 percent, from 4,678 DDD/1,000 new patients to 26,175 DDD/1,000 new patients. Expressed in grams of oral morphine equivalent (g OME), consumption increased by 644 percent, from 233 g OME/1,000 new patients to 1,731 g OME/1,000 new patients. The establishment of the PMU was associated with an increase in opioid consumption, especially morphine, which is an indicator of improvement in cancer pain control. The expression of opioid consumption in OME in addition to DDD may provide further information, especially when weak opioids are included in the analysis.

  10. Biological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell cultures

    Institute of Scientific and Technical Information of China (English)

    Stéphane Larré; Philippe Camparo; Eva Comperat; Delphine Boulbés; Mohammed Haddoum; Sylvain Baulande; Pascal Soularue; Pierre Costa; Olivier Cussenot

    2012-01-01

    Pygeum africanum (Tadenan) is a popular phytotherapeutic agent used in the treatment of symptomatic benign prostatic hyperplasia.The active compounds of the drug have not been identified,and determining the plasma concentration of the drug is,therefore,not possible.Because there are conflicting results on the efficacy of this drug,we aimed to investigate its effect on prostate cell growth in vitro using human serum collected before and after Pygeum africanum intake.We used primary and organotypic cultures of human prostatic stromal myofibroblast cell line WPMY and prostatic epithelial cell line PNT2.We also used fresh benign prostatic tissue.The serum of a treated man induced decreases in the proliferation of primary cells,organotypic cells and WPMY cells but not PNT2 cells.We also analysed the effect of treated serum on the gene expression profile of WPMY cells.The transcriptome analysis revealed an upregulation of genes involved in multiple tumour suppression pathways and a downregulation of genes involved in inflammation and oxidative-stress pathways.The oral intake of Pygeum africanum resulted in serum levels of active substances that were sufficient to inhibit the proliferation of cultured myofibroblasts prostatic cells.This inhibition was associated with changes in the transcriptome.

  11. Evaluation of physicians' knowledge about prevention of rheumatic fever and rheumatic heart disease before and after a teaching session.

    Science.gov (United States)

    Osman, Gehan M; Abdelrahman, Sirageldin M K; Ali, Sulafa K M

    2015-01-01

    Rheumatic fever (RF) and rheumatic heart disease RHD remain as one of the major cardiovascular problems in Sudanese children. The cornerstones for control of RF and RHD are primary and secondary preventions as adopted by Sudan's programme. This study aimed to describe and raise the paediatric doctors' awareness about prevention of RF and RHD using lectures. It was a prospective, cross-sectional, hospital based study, conducted in Khartoum. The study populations were paediatric doctors including house officers, medical officers and registrars. Data were collected through self-administered questionnaire, which was constructed to assess the doctor's awareness about RF and RHD prevention before and after attending lectures. Eighty seven doctors participated in the study. The results showed that the overall doctors' awareness about prevention of rheumatic fever and rheumatic heart disease was at average level. It was raised by intervention through lectures to good level. It is recommended to introduce training programs for physicians in order to improve doctors' awareness about prevention of RF and RHD. Such activities need to be conducted at regular intervals. PMID:27493434

  12. Comparison of before and after CBCT image registration based on the lung cancer intensity-modulated planning

    International Nuclear Information System (INIS)

    Objective: To study the CBCT image registration of PTV enlarging distance and IMRT planning (CT-1) for patients with lung cancer,and evaluate their characters. Methods: Ten patients with lung cancer were included in the study. Two sets image, before and after radiotherapy, were acquired every week. Then delineated the targeted volume and made the planning (CT-2) according the enlarging distance data. To compare the parameters of DVH for lung and spinal cord, volumes and dose of PTV and NTCP with CT-1 and CT-2. The difference of two plan was analyzed by covariance analysis or Wilcoxson's z-test. Results: The max, min and mean dose of PTV, the lung V5, V10, V20, V30, V50 were similar in both plans (P =0.242-0.663). There was superiority in CT-2 of PTV and lung's mean dose (P =0.049, 0.035). The NTCP had the decent tendency followed by the increasing of lung V5, V10, V20 (P =0.146, 0.053, 0.000). Conclusions: CBCT based image registration can reduce PTV, the mean dose of lung, NTCP, and increase PTV dose. This provides a tool for exploring accurate radiotherapy strategies. (authors)

  13. Impact of Endografting on the Thoracic Aortic Anatomy: Comparative Analysis of the Aortic Geometry before and after the Endograft Implantation

    Energy Technology Data Exchange (ETDEWEB)

    Midulla, Marco, E-mail: marco.midulla@chru-lille.fr [University Hospital of Lille, Cardiovascular and Interventional Radiology (France); Moreno, Ramiro, E-mail: ramoroa@gmail.com [Rangueil University Hospital, Department of Radiology (France); Negre-Salvayre, Anne, E-mail: anne.negre-salvayre@inserm.fr [INSERM, UMR 1048, I2MC (France); Nicoud, Franc, E-mail: franck.nicoud@univ-montp2.fr [CNRS, UMR 5149 I3M, CC 051, University Montpellier II (France); Pruvo, Jean Pierre, E-mail: jean-pierre.pruvo@chru-lille.fr [University Hospital of Lille, Cardiovascular and Interventional Radiology (France); Haulon, Stephan, E-mail: stephan.haulon@chru-lille.fr [University Hospital of Lille, Department of Vascular Surgery (France); Rousseau, Hervé, E-mail: rousseau.h@chu-toulouse.fr [Rangueil University Hospital, Department of Radiology (France)

    2013-03-13

    PurposeAlthough the widespread acceptance of thoracic endovascular aortic repair (TEVAR) as a first-line treatment option for a multitude of thoracic aortic diseases, little is known about the consequences of the device implantation on the native aortic anatomy. We propose a comparative analysis of the pre- and postoperative geometry on a clinical series of patients and discuss the potential clinical implicationsMethodsCT pre- and postoperative acquisitions of 30 consecutive patients treated by TEVAR for different pathologies (20 thoracic aortic aneurysms, 6 false aneurysms, 3 penetrating ulcers, 1 traumatic rupture) were used to model the vascular geometry. Pre- and postoperative geometries were compared for each patient by pairing and matching the 3D models. An implantation site was identified, and focal differences were detected and described.ResultsSegmentation of the data sets was successfully performed for all 30 subjects. Geometry differences between the pre- and postoperative meshes were depicted in 23 patients (76 %). Modifications at the upper implantation site were detected in 14 patients (47 %), and among them, the implantation site involved the arch (Z0–3) in 11 (78 %).ConclusionModeling the vascular geometry on the basis of imaging data offers an effective tool to perform patient-specific analysis of the vascular geometry before and after the treatment. Future studies will evaluate the consequences of these changes on the aortic function.

  14. Heart rate variability in non-apneic snorers and controls before and after continuous positive airway pressure

    Directory of Open Access Journals (Sweden)

    Mateika Jason H

    2005-07-01

    Full Text Available Abstract Background We hypothesized that sympathetic nervous system activity (SNSA is increased and parasympathetic nervous system activity (PNSA is decreased during non-rapid eye movement (NREM sleep in non-apneic, otherwise healthy, snoring individuals compared to control. Moreover, we hypothesized that these alterations in snoring individuals would be more evident during non-snoring than snoring when compared to control. Methods To test these hypotheses, heart rate variability was used to measure PNSA and SNSA in 11 normotensive non-apneic snorers and 12 control subjects before and 7-days after adapting to nasal continuous positive airway pressure (nCPAP. Results Our results showed that SNSA was increased and PNSA was decreased in non-apneic snorers during NREM compared to control. However, these changes were only evident during the study in which snoring was eliminated with nCPAP. Conversely, during periods of snoring SNSA and PNSA were similar to measures obtained from the control group. Additionally, within the control group, SNSA and PNSA did not vary before and after nCPAP application. Conclusion Our findings suggest that long-lasting alterations in autonomic function may exist in snoring subjects that are otherwise healthy. Moreover, we speculate that because of competing inputs (i.e. inhibitory versus excitatory inputs to the autonomic nervous system during snoring, the full impact of snoring on autonomic function is most evident during non-snoring periods.

  15. Gait analysis before and after achilles tendon surgical suture in a single-subject study: a case report.

    Science.gov (United States)

    Marcolin, Giuseppe; Buriani, Alessandro; Balasso, Alberto; Villaminar, Renato; Petrone, Nicola

    2015-01-01

    Achilles tendon rupture is a disabling injury that requires a long recovery time. We describe a unique case of a 46-year-old male who had undergone gait analysis as part of a personal physical examination and who, 16 months later, ruptured his left Achilles tendon while running. With gait kinematic and kinetic data available both before and after his injury, we determined the residual gait asymmetries on his uninjured side and compared the pre- and postinjury measurements. We analyzed his gait at 1, 4, and 7 weeks after his return to full weightbearing. Compared with the preinjury values, at 7 weeks he had almost complete range of motion in his left ankle (-2%) and a slight increase in gait velocity (+6%) and cadence (+3%). The peak power of his injured ankle was 90% of its preinjury value. In contrast, the unaffected ankle was at 118%. These observations suggest that measuring the asymmetries of the gait cycle, especially at the beginning of rehabilitation, can be used to improve treatment. We had the patient strengthen his ankle using a stationary bicycle before he returned to running. Kinetics also appears to be more powerful than kinematics in detecting functional asymmetries associated with reduced calf strength, even 15 weeks after surgery. Gait analysis could be used to predict the effectiveness of rehabilitation protocols and help calibrate and monitor the return to sports participation while preventing overloading muscle and tendon syndromes.

  16. Parenting a child with autism in India: narratives before and after a parent-child intervention program.

    Science.gov (United States)

    Brezis, Rachel S; Weisner, Thomas S; Daley, Tamara C; Singhal, Nidhi; Barua, Merry; Chollera, Shreya P

    2015-06-01

    In many low and middle income countries where autism-related resources are scarce, interventions must rely on family and parents. A 3-month Parent-Child Training Program (PCTP) at Action For Autism, New Delhi, India is aimed at empowering and educating parents, encouraging acceptance of their child, and decreasing parent stress. Forty couples were asked to describe their child with autism using the Five Minute Speech Sample (FMSS), an open-ended narrative method, before and after the program. Parents described a wide range of child behaviors, primarily social and cognitive skills. While all families were of a relatively affluent strata compared to the general Indian population, there were nonetheless significant differences in parents' narratives based on their income levels. Coming into the program, parents with relatively less income focused on their child's immediate and material needs, while higher income parents discussed their parental roles and vision for society. After the PCTP, parents were more likely to reflect on their child beyond comparisons to 'normality,' and beyond the here-and-now. Mothers were more likely than fathers to reflect on themselves and their relationships with their child. Understanding parents' experiences and narratives is essential for the evaluation of interventions such as the PCTP, as Indian parents are incorporated into a growing global network of 'parents of children with autism.' PMID:25739529

  17. Studying of some physical properties for natural polymers (hemoglobin) for cancer patients before and after exposure to gamma irradiation

    International Nuclear Information System (INIS)

    The effect of radiotherapy on hemoglobin (Hb) polymer, obtained from patients (cases) before and after two periods of local gamma irradiation was studied. The results were compared with healthy volunteer. The patients were classified into two main groups. The first group represents cases that suffer from breast cancer, while, the second group represents cases that suffer from pelvic cancer. The total doses for breast cancer were ranged from 45 to 50 Gy, divided into 25 fractions for 5 weeks. While the total doses for pelvic irradiation were ranged from 20 to 66 Gy; divided into 10-25 fraction for 2-5 weeks. The physical properties of Hb have been studied via several characterization techniques, such as X-ray diffraction, viscosity, Fourier Transform Infra-red spectroscopy (FTIR), Electron Spin Resonance (ESR) and UV-visible spectra. The resultant effects of radiotherapy can be summarized as follows: X-ray diffraction pattern of Hb polymer, for control and cancer breast before and after exposure to accumulated gamma irradiation, were characterized by halo consisting of two adjacent peaks with maximum intensity observed at 2θ = 9.549 and 21.222, respectively. By increasing the gamma doses, a decrease in crystalline phase (disordering character) were obtained. Also, the halos width at half of maximal intensity (δW) shows a decrease followed by an increase with increasing the accumulative gamma dose up to 50 Gy, but still below + ve and -ve control values. The viscosity were measured for Hb solutions of concentration 4.1x10-5 Mol on the base of heme-heme interaction and at different shear rates (10-400 sec-1). The plastic viscosity for every hemoglobin samples was calculated by Bingham equation using specific software of the viscometer. There was an increase in the plastic viscosity of Hb cancer patients compared to -ve control. On irradiation the viscosity shows an increase with increasing the accumulative gamma dose. Fourier transform infra-red spectra (FTIR

  18. Marginal and internal adaptation of Class II ormocer and hybrid resin composite restorations before and after load cycling.

    Science.gov (United States)

    Kournetas, N; Chakmakchi, M; Kakaboura, A; Rahiotis, C; Geis-Gerstorfer, J

    2004-09-01

    To overcome the shortcomings of the conventional composite restorative materials, ormocer materials have been introduced over the past few years. The purpose of this study was to evaluate the marginal and internal adaptation of two ormocer restorative systems (Admira, Voco and Definite, Degussa) compared to a hybrid composite one (TPH Spectrum, Dentsply/ DeTrey), before and after load cycling in Class II restorations. Standardized Class II restorations with cervical margins on enamel were divided into three groups ( n=16). Teeth of each group were filled with one of the restoratives tested and its respective bonding agent. Each group was divided into two equal subgroups. The marginal and internal adaptation of the first subgroup was evaluated after 7-day water storage at room temperature and of the second after cyclic loading in a mastication simulator (1.2x10(6) cycles, 49 N, 1.6 Hz). The occlusal and cervical marginal evaluation was conducted by videomicroscope and ranked as "excellent" and "not excellent". One thin section (150 microm), in mesial-distal direction, of each restoration, was examined under metallographic microscope to determine the quality of internal adaptation. The occlusal and cervical adaptation of both ormocer restorative systems was similar and clearly worse compared with the hybrid composite restorative one before as well as after load cycling. Concerning internal adaptation, no gap-free ormocer restorations were detected, whereas all Spectrum restorations presented perfect adaptation. The bonding agents of the ormocers formed layers with unacceptable features (pores, fractures) whereas that of the hybrid composite achieved perfect bonding layer even after loading. The rheological characteristics of the bonding agents of the ormocer restorative systems are proposed to be responsible for their inferior marginal and internal quality in Class II restorations compared with the hybrid composite one.

  19. Comparison of rates of referral and diagnosis of axial spondyloarthritis before and after an ankylosing spondylitis public awareness campaign.

    Science.gov (United States)

    Harrison, Andrew A; Badenhorst, Christoffel; Kirby, Sandra; White, Douglas; Athens, Josie; Stebbings, Simon

    2014-07-01

    The objective of this research is to measure the effect of a national ankylosing spondylitis (AS) public awareness campaign on numbers of referrals for suspected AS and numbers of cases diagnosed with axial spondyloarthritis (SpA). A television advertising campaign was conducted by Arthritis New Zealand in 2011 to raise public awareness of AS. A retrospective analysis was made of referrals received by the three rheumatology services 3 months before the campaign started and 3 months after the campaign ended. The age, gender, number of referrals for suspected AS and number of referrals resulting in a diagnosis of axial SpA were recorded. Independent analysis showed that the awareness campaign reached 82 % of the primary target audience. In the 3 months after the awareness campaign, there was a significant increase in referrals for suspected AS compared with the 3 months before the campaign (54 vs. 88, 63 %, p = 0.0056). Referrals for other conditions did not change. The number of referrals resulting in a diagnosis of axial SpA also increased (27 vs. 44, 63 %, p = 0.0576). The mean ages of the patients referred and of those diagnosed with axial SpA did not change. The male/female ratio was 1:1 among the referrals for suspected AS and 2:1 in referrals diagnosed with axial SpA, before and after the campaign. The Arthritis New Zealand AS public awareness campaign was associated with a significant increase in referrals to rheumatology services for suspected AS and an increase in the diagnosis of axial SpA in clinics. PMID:24609715

  20. A Comparison of Frontal Theta Activity During Shooting among Biathletes and Cross-Country Skiers before and after Vigorous Exercise.

    Directory of Open Access Journals (Sweden)

    Harri Luchsinger

    Full Text Available Previous studies using electroencephalography (EEG to monitor brain activity have linked higher frontal theta activity to more focused attention and superior performance in goal-directed precision tasks. In biathlon, shooting performance requires focused attention after high-intensity cross-country skiing.To compare biathletes (serving as experts and cross-country skiers (novices and examine the effect of vigorous exercise on frontal theta activity during shooting.EEG frontal theta (4-7 Hz activity was compared between nine biathletes and eight cross-country skiers at comparable skiing performance levels who fired 100 shots on a 5-m indoor shooting range in quiescent condition followed by 20 shots after each of five 6-min high-intensity roller skiing sessions in the skating technique on a treadmill.Biathletes hit 80±14% and 81±10% before and after the roller skiing sessions, respectively. For the cross-country skiers these values were significantly lower than for the biathletes and amounted to 39±13% and 44±11% (p<0.01. Biathletes had on average 6% higher frontal theta activity during shooting as compared to cross-country skiers (F1,15 = 4.82, p = 0.044, but no significant effect of vigorous exercise on frontal theta activity in either of the two groups were found (F1,15 = 0.14, p = 0.72.Biathletes had significantly higher frontal theta activity than cross-country skiers during shooting, indicating higher focused attention in biathletes. Vigorous exercise did not decrease shooting performance or frontal theta activity during shooting in biathletes and cross-country skiers.

  1. Temporal variation of shear-wave splitting parameters before and after the 2008 Movri Mountain earthquake in northwest Peloponnese (Greece

    Directory of Open Access Journals (Sweden)

    Dimitrios Giannopoulos

    2013-02-01

    Full Text Available On June 8, 2008, at 12:25 GMT, a Mw 6.4 earthquake, the Movri Mountain earthquake, occurred in the area of northwest Peloponnese, western Greece. The epicenter was located in the municipality of Movri, 35 km southwest of Patras. For this study, a crustal anisotropy analysis was performed in the epicentral area of the Movri Mountain earthquake. Specifically, the shear-wave splitting phenomenon and its temporal evolution in relation to the Movri Mountain earthquake was studied, using the cross-correlation method. The data analysis revealed the presence of shear-wave splitting in the study area. Both before and after the Movri Mountain earthquake, the polarization directions of the fast component of the shear waves followed a general NNW-SSE direction. The observed mean fast polarization direction was not consistent with the regional stress field, which showed a general E-W direction of the maximum horizontal compressive stress. The differences between the estimated fast polarization directions and the properties of the regional stress field suggest the presence of a local stress field in the area around the fault. An increase in time delays was observed soon after the Movri Mountain earthquake. The average value of the delay times before the earthquake was ca. 18 ±2.6 ms, while after the earthquake this was ca. 40 ±4.6 ms. This increase in the time delay indicates changes in the crustal properties, which were possibly caused by variations in the pre-existing micro-crack system characteristics related to the Movri Mountain earthquake, and the possible involvement of over-pressured fluids.

  2. Evaluation of slim-edge, multi-guard, and punch-through-protection structures before and after proton irradiation

    International Nuclear Information System (INIS)

    Planar geometry silicon pixel and strip sensors for the high luminosity upgrade of the LHC (HL-LHC) require a high bias voltage of 1000 V in order to withstand a radiation damage caused by particle fluences of 1×1016 1 MeV neq/cm2 and 1×1015 1 MeV neq/cm2 for pixel and strip detectors, respectively. In order to minimize the inactive edge space that can withstand a bias voltage of 1000 V, edge regions susceptible to microdischarge (MD) should be carefully optimized. We fabricated diodes with various edge distances (slim-edge diodes) and with 1–3 multiple guard rings (multi-guard diodes). AC coupling insulators of strip sensors are vulnerable to sudden heavy charge deposition, such as an accidental beam splash, which may destroy the readout AC capacitors. Thus various types of punch-through-protection (PTP) structures were implemented in order to find the most effective structure to protect against heavy charge deposition. These samples were irradiated with 70 MeV protons at fluences of 5×1012 1 MeV neq/cm2–1×1016 1 MeV neq/cm2. Their performances were evaluated before and after irradiation in terms of an onset voltage of the MD, a turn-on voltage of the PTP, and PTP saturation resistance. -- Highlights: ► We have evaluated radiation tolerance of n-in-p sensors up to 1×1016 1 MeV neq/cm2. ► Both n-bulk and p-bulk require a field width≥450 μm in order to withstand 1000 V. ► The MD onset voltage was found to be independent of the edge width. ► With increasing number of guard rings, bias voltage tolerance improved before irrad. ► BZ4D-5 (with full extension) performs the best among the samples.

  3. Genome-Wide Evolutionary Analyses of G1P[8] Strains Isolated Before and After Rotavirus Vaccine Introduction

    Science.gov (United States)

    Zeller, Mark; Donato, Celeste; Trovão, Nídia Sequeira; Cowley, Daniel; Heylen, Elisabeth; Donker, Nicole C.; McAllen, John K.; Akopov, Asmik; Kirkness, Ewen F.; Lemey, Philippe; Van Ranst, Marc; Matthijnssens, Jelle; Kirkwood, Carl D.

    2015-01-01

    Rotaviruses are the most important etiological agent of acute gastroenteritis in young children worldwide. Among the first countries to introduce rotavirus vaccines into their national immunization programs were Belgium (November 2006) and Australia (July 2007). Surveillance programs in Belgium (since 1999) and Australia (since 1989) offer the opportunity to perform a detailed comparison of rotavirus strains circulating pre- and postvaccine introduction. G1P[8] rotaviruses are the most prominent genotype in humans, and a total of 157 G1P[8] rotaviruses isolated between 1999 and 2011 were selected from Belgium and Australia and their complete genomes were sequenced. Phylogenetic analysis showed evidence of frequent reassortment among Belgian and Australian G1P[8] rotaviruses. Although many different phylogenetic subclusters were present before and after vaccine introduction, some unique clusters were only identified after vaccine introduction, which could be due to natural fluctuation or the first signs of vaccine-driven evolution. The times to the most recent common ancestors for the Belgian and Australian G1P[8] rotaviruses ranged from 1846 to 1955 depending on the gene segment, with VP7 and NSP4 resulting in the most recent estimates. We found no evidence that rotavirus population size was affected after vaccine introduction and only six amino acid sites in VP2, VP3, VP7, and NSP1 were identified to be under positive selective pressure. Continued surveillance of G1P[8] strains is needed to determine long-term effects of vaccine introductions, particularly now rotavirus vaccines are implemented in the national immunization programs of an increasing number of countries worldwide. PMID:26254487

  4. Genome-Wide Evolutionary Analyses of G1P[8] Strains Isolated Before and After Rotavirus Vaccine Introduction.

    Science.gov (United States)

    Zeller, Mark; Donato, Celeste; Trovão, Nídia Sequeira; Cowley, Daniel; Heylen, Elisabeth; Donker, Nicole C; McAllen, John K; Akopov, Asmik; Kirkness, Ewen F; Lemey, Philippe; Van Ranst, Marc; Matthijnssens, Jelle; Kirkwood, Carl D

    2015-09-01

    Rotaviruses are the most important etiological agent of acute gastroenteritis in young children worldwide. Among the first countries to introduce rotavirus vaccines into their national immunization programs were Belgium (November 2006) and Australia (July 2007). Surveillance programs in Belgium (since 1999) and Australia (since 1989) offer the opportunity to perform a detailed comparison of rotavirus strains circulating pre- and postvaccine introduction. G1P[8] rotaviruses are the most prominent genotype in humans, and a total of 157 G1P[8] rotaviruses isolated between 1999 and 2011 were selected from Belgium and Australia and their complete genomes were sequenced. Phylogenetic analysis showed evidence of frequent reassortment among Belgian and Australian G1P[8] rotaviruses. Although many different phylogenetic subclusters were present before and after vaccine introduction, some unique clusters were only identified after vaccine introduction, which could be due to natural fluctuation or the first signs of vaccine-driven evolution. The times to the most recent common ancestors for the Belgian and Australian G1P[8] rotaviruses ranged from 1846 to 1955 depending on the gene segment, with VP7 and NSP4 resulting in the most recent estimates. We found no evidence that rotavirus population size was affected after vaccine introduction and only six amino acid sites in VP2, VP3, VP7, and NSP1 were identified to be under positive selective pressure. Continued surveillance of G1P[8] strains is needed to determine long-term effects of vaccine introductions, particularly now rotavirus vaccines are implemented in the national immunization programs of an increasing number of countries worldwide. PMID:26254487

  5. Hospital admissions for acute myocardial infarction before and after implementation of a comprehensive smoke-free policy in Uruguay

    Science.gov (United States)

    Sebrié, Ernesto Marcelo; Sandoya, Edgardo; Hyland, Andrew; Bianco, Eduardo; Glantz, Stanton A; Cummings, K Michael

    2012-01-01

    Background Stimulated by the WHO Framework Convention on Tobacco Control, many countries in Latin America adopted comprehensive smoke-free policies. In March 2006, Uruguay became the first Latin American country to adopt 100% smoke-free national legislation, which ended smoking in all indoor public places and workplaces, including restaurants and bars. The objective of this study was to evaluate trends in hospital admissions for cardiovascular disease 2 years before and 2 years after the policy was implemented in Uruguay. Methods Reports of hospital admissions for acute myocardial infarction (AMI) (International Classification of Disease-10 I21) from 37 hospitals (79% of all hospital admissions in the country), representing the period 2 years before and 2 years after the adoption of a nationwide smoke-free policy in Uruguay (between 1 March 2004 and 29 February 2008), were reviewed. A time series analysis was undertaken to compare the average monthly number of events of hospital admission for AMI before and after the smoke-free law. Results A total of 7949 hospital admissions for AMI were identified during the 4-year study period. Two years after the smoke-free policy was enacted, hospital admissions for AMI fell by 22%. The same pattern and roughly the same magnitude of reduction in AMI admissions were observed for patients seen in public and private hospitals, men, women and people aged 40–65 years and older than 65 years. Conclusions The national smoke-free policy implemented in Uruguay in 2006 was associated with a significant reduction in hospital admissions for AMI. PMID:22337557

  6. Force spectroscopy of membrane hardness of SH-SY5Y neuroblastoma cells before and after differentiation

    Science.gov (United States)

    Kwon, Sangwoo; Yang, Woochul; Choi, Yun Kyong; Park, Jung Keuck

    2014-05-01

    Atomic force microscopy (AFM) is utilized in many studies for measuring the structure and the physical characteristics of soft and bio materials. In particular, the force spectroscopy function in the AFM system allows us to explore the mechanical properties of bio cells. In this study, we probe the variation in the membrane hardness of human neuroblastoma SH-SY5Y cells (SH-cells) before and after differentiation by using force spectroscopy. The SH-cell, which is usually differentiated by using a chemical treatment with retinoic acid (RA), is a neuronal cell line employed widely as an in-vitro model for neuroscience research. In force spectroscopy, the force-distance curves are obtained from both the original and the RA-treated cells while the AFM tip approaches and pushes on the cell membranes. The slope deduced from linear region in the force-distance curve is the spring constant and corresponds to the hardness of the cell membrane. The spring constant of the RA-treated cells (0.597 ± 0.010 nN/nm) was smaller than that of the original cells (0.794 ± 0.010 nN/nm), reflecting a hardness decrease in the cells differentiated with the RA treatments. The results clearly demonstrated that the differentiated cells are softer than the original cells. The change in the elasticity of the differentiated cells might be caused by morphological modification during differentiation process. We suggest that force spectroscopy can be employed as a novel method to determine the degree of differentiation of stem cells into various functional cells.

  7. Iodine isotopes in precipitation: Four-year time series variations before and after 2011 Fukushima nuclear accident.

    Science.gov (United States)

    Xu, Sheng; Zhang, Luyuan; Freeman, Stewart P H T; Hou, Xiaolin; Watanabe, Akira; Sanderson, David C W; Cresswell, Alan; Yamaguchi, Katsuhiko

    2016-05-01

    Rainwater samples were collected monthly from Fukushima, Japan, in 2012-2014 and analysed for (127)I and (129)I. These are combined with previously reported data to investigate atmospheric levels and behaviour of Fukushima-derived (129)I before and after the 2011 nuclear accident. In the new datasets, (127)I and (129)I concentrations between October 2012 and October 2014 varied from 0.5 to 10 μg/L and from 1.2 × 10(8) to 6.9 × 10(9) atoms/L respectively, resulting in (129)I/(127)I atomic ratio ranges from 3 × 10(-8) to 2 × 10(-7). The (127)I concentrations were in good agreement with those in the previous period from March 2011 to September 2012, whereas the (129)I concentrations and (129)I/(127)I ratios followed declining trends since the accident. Although (129)I concentrations in five samples during the period of 2013-2014 have approached the pre-accident levels, (129)I concentrations in most samples remained higher values in winter and spring-summer. The high (129)I levels in winter and spring-summer are most likely attributed to local resuspension of the Fukushima-derived radionuclide-bearing fine soil particles deposited on land surfaces, and re-emission through vegetation taking up (129)I from contaminated soil and water, respectively. Long-term declining rate suggests that contribution of the Fukushima-derived (129)I to the atmosphere would become less since 2014.

  8. Aortic annulus eccentricity before and after transcatheter aortic valve implantation: Comparison of balloon-expandable and self-expanding prostheses

    International Nuclear Information System (INIS)

    Highlights: • Post-implant geometry of catheter-based aortic valve prostheses is influenced by aortic valve calcification. • Balloon-expandable prostheses are more circular as compared to self-expanding prostheses. • The impact of post-implant geometry on valve function needs to be investigated. - Abstract: Introduction: The geometry of the aortic annulus and implanted transcatheter aortic valve prosthesis might influence valve function. We investigated the influence of valve type and aortic valve calcification on post-implant geometry of catheter-based aortic valve prostheses. Methods: Eighty consecutive patients with severe aortic valve stenosis (mean age 82 ± 6 years) underwent computed tomography before and after TAVI. Aortic annulus diameters were determined. Influence of prosthesis type and degree of aortic valve calcification on post-implant eccentricity were analysed. Results: Aortic annulus eccentricity was reduced in patients after TAVI (0.21 ± 0.06 vs. 0.08 ± 0.06, p < 0.0001). Post-TAVI eccentricity was significantly lower in 65 patients following implantation of a balloon-expandable prosthesis as compared to 15 patients who received a self-expanding prosthesis (0.06 ± 0.05 vs. 0.15 ± 0.07, p < 0.0001), even though the extent of aortic valve calcification was not different. After TAVI, patients with a higher calcium amount retained a significantly higher eccentricity compared to patients with lower amounts of calcium. Conclusions: Patients undergoing TAVI with a balloon-expandable prosthesis show a more circular shape of the implanted prosthesis as compared to patients with a self-expanding prosthesis. Eccentricity of the deployed prosthesis is affected by the extent of aortic valve calcification

  9. The Knowledge, Attitude and Behavior of HIV/AIDS Patients’ Family toward Their Patients before and after Counseling

    Directory of Open Access Journals (Sweden)

    Behnam Honarvar

    2010-12-01

    Full Text Available Background: Acquired immunodeficiency may impose considerableconsequences on patients’ family behaviors towardthem. The objective of the present study was to investigatewhether a counseling program at Behavioral Counseling Centerin the city of Shiraz, Iran could change the attitude, knowledgeand behavior of patients' family members.Methods: 125 HIV/AIDS patients’ family members were interviewed,using a valid and reliable questionnaire before andafter performing counseling sessions at Behavioral CounselingCenter. The findings were analyzed using nonparametric tests.Results: The age of the participants was 40±13 years. Sixty fivepercent were female, 63% married and 79% educated. Forty fourpercent of participants had spousal relationships with their patients.Their knowledge about the main routes of HIV transmissionwere 9.76 ± 2.59 and10.64±0.88 before and after counseling,respectively (P=0.028. Supportive behaviors of families towardtheir patients reached to 79% after counseling compared with 44% before that (P=0.004. Belief to isolate the patients and thepractice of this approach at home dropped from 71% to 15% andfrom 29% to 7% after counseling, respectively (P0.05.Conclusion: Ongoing counseling for HIV/AIDS patients’ familiesat Behavioral Counseling Center of Shiraz did advance theirknowledge about AIDS and improved their attitude and behaviortoward their patients However, the counseling program didnot show remarkable success in some aspects such as the removalof fear about HIV spread in the family or the change ofthe patients’ wives attitude to have protected sex with their HIVinfected husbands.Iran J Med Sci 2010; 35(4: 287-292.

  10. Gasoline-related organics in Lake Tahoe before and after prohibition of carbureted two-stroke engines

    Science.gov (United States)

    Lico, M.S.

    2004-01-01

    On June 1, 1999, carbureted two-stroke engines were banned on waters within the Lake Tahoe Basin of California and Nevada. The main gasoline components MTBE (methyl tert-butyl ether) and BTEX (benzene, toluene, ethylbenzene, and xylenes) were present at detectable concentrations in all samples taken from Lake Tahoe during 1997-98 prior to the ban. Samples taken from 1999 through 2001 after the ban contained between 10 and 60 percent of the pre-ban concentrations of these compounds, with MTBE exhibiting the most dramatic change (a 90 percent decrease). MTBE and BTEX concentrations in water samples from Lake Tahoe and Lower Echo Lake were related to the amount of boat use at the sampling sites. Polycyclic aromatic hydrocarbon (PAH) compounds are produced by high-temperature pyrolytic reactions. They were sampled using semipermeable membrane sampling devices in Lake Tahoe and nearby Donner Lake, where carbureted two-stroke engines are legal. PAHs were detected in all samples taken from Lake Tahoe and Donner Lake. The number of PAH compounds and their concentrations are related to boat use. The highest concentrations of PAH were detected in samples from two heavily used boating areas, Tahoe Keys Marina and Donner Lake boat ramp. Other sources of PAH, such as atmospheric deposition, wood smoke, tributary streams, and automobile exhaust do not contribute large amounts of PAH to Lake Tahoe. Similar numbers of PAH compounds and concentrations were found in Lake Tahoe before and after the ban of carbureted two-stroke engines. ?? by the North American Lake Management Society 2004.

  11. Public perceptions of climate change and energy futures before and after the Fukushima accident: A comparison between Britain and Japan

    International Nuclear Information System (INIS)

    The threats posed by climate change call for strong action from the international community to limit carbon emissions. Before the Fukushima accident that followed the Great East Japan earthquake and tsunami on 11 March 2011, both Britain and Japan were considering an ambitious expansion of nuclear power as part of their strategy to reduce carbon emissions. However, the accident may have thrown nuclear power as a publicly accep’ energy technology into doubt. This study uses several nationally representative surveys from before and after the Fukushima accident to examine how it may have changed public perceptions of climate change and energy futures in Britain and Japan. The study found that already before the accident the Japanese public were less supportive of nuclear power than the British. While British attitudes have remained remarkably stable over time, the Japanese public appear to have completely lost trust in nuclear safety and regulation, and have become less acceptive of nuclear power even if it would contribute to climate change mitigation or energy security. In Japan the public are now less likely to think that any specific energy source will contribute to a reliable and secure supply of energy. The implications for energy policy are discussed. - highlights: • We report data from 2005 to 2011 of British and Japanese attitudes towards nuclear power and climate change. • The Japanese are less supportive of nuclear power as a solution to climate change than the British. • Public support for and trust in nuclear power has collapsed in Japan after Fukushima. • British public attitudes to nuclear power are remarkably robust in the wake of Fukushima

  12. Blood gases and energy metabolites in mouse blood before and after cerebral ischemia: the effects of anesthetics.

    Science.gov (United States)

    Schwarzkopf, Tina M; Horn, Tobias; Lang, Dorothee; Klein, Jochen

    2013-01-01

    The levels of blood gases and energy metabolites strongly influence the outcome of animal experiments, for example in experimental stroke research. While mice have become prominent animal models for cerebral ischemia, little information is available on the effects of anesthetic drugs on blood parameters such as blood gases, glucose and lactate in this species. In this work, we collected arterial and venous blood samples from female CD-1 mice before and after cerebral ischemia induced by middle cerebral artery occlusion (MCAO), and we tested the influence of different anesthetic drugs. We found that all of the injectable anesthetics tested (ketamine/xylazine, chloral hydrate, propofol and pentobarbital) caused a decrease in blood pH and partial pressure of oxygen (pO2) and an increase of partial pressure of carbon dioxide (pCO2), indicating respiratory depression. This was not observed with inhalable anesthetics such as isoflurane, sevoflurane and halothane. Significant and up to two-fold increases of blood glucose concentration were observed under isoflurane, halothane, ketamine/xylazine, chloral hydrate, and propofol anesthesia. Lactate concentration rose significantly by 2-3-fold during inhalation of isoflurane and halothane treatment, but decreased by more than 50% after administration of pentobarbital. Permanent cerebral ischemia induced respiratory acidosis (low pH and pO2, high pCO2) which was most prominent after 24 h. Postsurgical treatment with Ringer-lactate solution (1 mL, intraperitoneal) caused a recovery of blood gases to basal levels after 24 h. Use of isoflurane for surgery caused a minor increase of blood glucose concentrations after one hour, but a strong increase of blood lactate. In contrast, anesthesia with pentobarbital did not affect glucose concentration but strongly reduced blood lactate concentrations one hour after surgery. All values recovered at three hours after MCAO. In conclusion, anesthetic drugs have a strong influence on murine

  13. Precise Sediment Yield and Riverbed Change Detected by using LiDAR DTMs before and after a Typhoon Season

    Science.gov (United States)

    Hsieh, Y.; Chan, Y.; Hu, J.; Lin, C.

    2009-12-01

    Sediment yield and riverbed change from watersheds greatly influence the conservation of water and soil, the planning of hydraulic engineering, and the river habitat, etc. At present, sediment yield calculation often used empirical or theoretical formula as well as data collected at hydrological stations, and rarely had the actual measured value through high-resolution topography. The Lanyang river is one of main rivers in Taiwan and often suffers the influence of typhoon during summer. In 2008, there are four significant typhoon events influencing this area, including the Kalmaegi, Fung-wong, Sinlaku, and Jangmi typhoons. This study of topographic variations surveyed the terrain of the Lanyang River before and after the 2008 typhoon season using airborne LiDAR technique. The variations of the terrain on the riverbed may be regarded as the sediment yield of the bed load transported during the typhoon season. This research used high-resolution terrain models to compute sediment yield of the bed load, and further discussed sediment yield volume in the watershed during the typhoon season. In the Lanyang river we discovered that the upstream and midstream channels had significant characteristics of erosion and transportation during the typhoon season. The sediment on the riverbed reduced approximately 2.3 million cubic meters; and the erosion rate of the bed load sediments were estimated about 3.4 mm during the 2008 typhoon season. The results indicate that considerable sediment yield and transportation in the Lanyang river during only a single typhoon season in which cumulated rain falls are high. Further analysis of the collected data in the Lanyang river are needed to better understand the typhoon influence and apply the results to the prevention of the common flash flooding hazards.

  14. Aortic annulus eccentricity before and after transcatheter aortic valve implantation: Comparison of balloon-expandable and self-expanding prostheses

    Energy Technology Data Exchange (ETDEWEB)

    Schuhbaeck, Annika, E-mail: annika.schuhbaeck@uk-erlangen.de [Department of Cardiology, University of Erlangen, Erlangen (Germany); Weingartner, Christina [Department of Cardiology, University of Gießen, Giessen (Germany); Arnold, Martin; Schmid, Jasmin; Pflederer, Tobias; Marwan, Mohamed [Department of Cardiology, University of Erlangen, Erlangen (Germany); Rixe, Johannes; Nef, Holger [Department of Cardiology, University of Gießen, Giessen (Germany); Schneider, Christian [Department of Radiology, University of Gießen, Giessen (Germany); Lell, Michael; Uder, Michael [Department of Radiology, University of Erlangen, Erlangen (Germany); Ensminger, Stephan [Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen (Germany); Feyrer, Richard; Weyand, Michael [Department of Cardiothoracic Surgery, University of Erlangen, Erlangen (Germany); Achenbach, Stephan [Department of Cardiology, University of Erlangen, Erlangen (Germany)

    2015-07-15

    Highlights: • Post-implant geometry of catheter-based aortic valve prostheses is influenced by aortic valve calcification. • Balloon-expandable prostheses are more circular as compared to self-expanding prostheses. • The impact of post-implant geometry on valve function needs to be investigated. - Abstract: Introduction: The geometry of the aortic annulus and implanted transcatheter aortic valve prosthesis might influence valve function. We investigated the influence of valve type and aortic valve calcification on post-implant geometry of catheter-based aortic valve prostheses. Methods: Eighty consecutive patients with severe aortic valve stenosis (mean age 82 ± 6 years) underwent computed tomography before and after TAVI. Aortic annulus diameters were determined. Influence of prosthesis type and degree of aortic valve calcification on post-implant eccentricity were analysed. Results: Aortic annulus eccentricity was reduced in patients after TAVI (0.21 ± 0.06 vs. 0.08 ± 0.06, p < 0.0001). Post-TAVI eccentricity was significantly lower in 65 patients following implantation of a balloon-expandable prosthesis as compared to 15 patients who received a self-expanding prosthesis (0.06 ± 0.05 vs. 0.15 ± 0.07, p < 0.0001), even though the extent of aortic valve calcification was not different. After TAVI, patients with a higher calcium amount retained a significantly higher eccentricity compared to patients with lower amounts of calcium. Conclusions: Patients undergoing TAVI with a balloon-expandable prosthesis show a more circular shape of the implanted prosthesis as compared to patients with a self-expanding prosthesis. Eccentricity of the deployed prosthesis is affected by the extent of aortic valve calcification.

  15. Opuntia ficus-indica ingestion stimulates peripheral disposal of oral glucose before and after exercise in healthy men.

    Science.gov (United States)

    Van Proeyen, Karen; Ramaekers, Monique; Pischel, Ivo; Hespel, Peter

    2012-08-01

    The purpose of this study was to investigate the effect of Opuntia ficus-indica (OFI) cladode and fruit-skin extract on blood glucose and plasma insulin increments due to high-dose carbohydrate ingestion, before and after exercise. Healthy, physically active men (n = 6; 21.0 ± 1.6 years, 78.1 ± 6.0 kg) participated in a double-blind placebo-controlled crossover study involving 2 experimental sessions. In each session, the subjects successively underwent an oral glucose tolerance test at rest (OGTT(R)), a 30-min cycling bout at ~75% VO(2max), and another OGTT after exercise (OGTT(EX)). They received capsules containing either 1,000 mg OFI or placebo (PL) 30 min before and immediately after the OGTT(R). Blood samples were collected before (t₀) and at 30-min intervals after ingestion of 75 g glucose for determination of blood glucose and serum insulin. In OGTT(EX) an additional 75-g oral glucose bolus was administered at t₆₀. In OGTT(R), OFI administration reduced the area under the glucose curve (AUC(GLUC)) by 26%, mainly due to lower blood glucose levels at t₃₀ and t₆₀ (p < .05). Furthermore, a higher serum insulin concentration was noted after OFI intake at baseline and at t₃₀ (p < .05). In OGTT(EX), blood glucose at t₆₀ was ~10% lower in OFI than in PL, which resulted in a decreased AUC(GLUC) (-37%, p < .05). However, insulin values and AUC(INS) were not different between OFI and PL. In conclusion, the current study shows that OFI extract can increase plasma insulin and thereby facilitate the clearance of an oral glucose load from the circulation at rest and after endurance exercise in healthy men.

  16. Comparing the Effect of Dexamethasone before and after Tracheal Intubation on Sore Throat after Tympanoplasty Surgery: A Randomized Controlled trial

    Directory of Open Access Journals (Sweden)

    Mahmoud Eidi

    2014-04-01

    Full Text Available Introduction: Presence of a sore throat after surgery is a common side effect of general anesthesia with intratracheal intubation and can cause discomfort for the patient and prolong the recovery process. In this study we compared the effect of dexamethasone before and after intubation on the incidence of sore throat after tympanoplasty surgery.   Materials and Methods: In a double-blind, randomized clinical trial, 70 patients aged 30–60 years with American Society of Anesthesiologists (ASA physical status I or II who were candidates for tympanoplasty under anesthetic conditions were studied in two separate groups. The first group received intravenous (IV dexamethasone (8 mg 30 mins prior to intubation while the second group received the same dose of dexamethasone 30 mins after intubation. The incidence and severity of the sore throat in both groups were then evaluated.   Results: There was no significant difference between two groups in intensity of sore throat (62.9% vs. 57.1%, cough (65.7% vs. 62.9%, or hoarseness (62.9% vs. 65.7% within 24 h after surgery. Detection of blood in oral secretions or on the tracheal tube was the same in both groups (5.7%. The incidence of coughs during the extubation was 0% in first group and 11.4% in second group.   Conclusion:  According to the results of this research there was no significant difference in incidence and intensity of sore throat in patients receiving dexamethasone before or after intubation. Further, no significant difference in intensity of coughs or hoarseness was observed.  

  17. Comparing Cystatin C Changes as a Measure of Renal Function Before and After Radiotherapy in Patients with Stomach Cancer

    Directory of Open Access Journals (Sweden)

    Ahmad Ameri

    2012-01-01

    Full Text Available The objective of this study was to determine and compare Cystatin C changes before and after radiotherapy in patients with stomach cancer who were candidate for radiotherapy. This study was conducted as a prospective cohort one. Eighteen patients with definite diagnosis of stomach cancer under treatment by radiotherapy who presented to Radiotherapy-Oncology Center of Imam Hossein Hospital, Tehran-Iran, and the treatment in all cases was simultaneous chemoradiation with Xeloda were included. In all patients before radiotherapy and after radiotherapy serum creatinine (Cr and Cystatin C were measured simultaneously. Mean cystatin level before treatment (1.2±0.4 was significantly lower than that of post-treatment (1.6±0.36, (P=0.001. Serum Cr level before treatment was 1.15±0.33 and after radiotherapy was 1.08±0.24 and did not show significant difference. Glomerular filtration rate (GFR of the patients before radiotherapy was -46.8 ± 21.0 and after radiotherapy was 43.8±15.8 that did not have significant difference (P=0.146 and also blood urea nitrogen (BUN before radiotherapy was 20.72±3.7 and 20 ± 6.38 after radiotherapy that did not have significant difference (P=0.6. Comparison of the Cystatin C difference with total radiation dose of the kidneys that are put in three dose groups in radiotherapy field had association that in dose of less that 18 gray (Gy the Cystatin C change showed significant and positive association (P=0.027; r=0.52 and about 18-24 Gy the Cystatin C difference showed significant and negative association (P=0.023, r=-0.53. It seems that for evaluating the renal function, serum Cystatin C measurement is preferable than serum Cr. level.

  18. Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

    International Nuclear Information System (INIS)

    A frequent side effect after radiotherapy of lung tumors is a decrease of pulmonary function accompanied by dyspnea due to developing lung fibrosis. The aim of this study was to monitor lung motion as a correlate of pulmonary function and intrathoracic tumor mobility before and after radiotherapy (RT) using dynamic MRI (dMRI). Thirty-five patients with stage I non-small-cell lung carcinoma were examined using dMRI (trueFISP; three images/s). Tumors were divided into T1 and T2 tumors of the upper, middle and lower lung region (LR). Maximum craniocaudal (CC) lung dimensions and tumor mobility in three dimensions were monitored. Vital capacity (VC) was measured and correlated using spirometry. Before RT, the maximum CC motion of the tumor-bearing hemithorax was 5.2±0.9 cm if the tumor was located in the lower LR (middle LR: 5.5±0.8 cm; upper LR: 6.0±0.6 cm). After RT, lung motion was significantly reduced in the lower LR (P<0.05). Before RT, the maximum CC tumor mobility was significantly higher in tumors of the lower LR 2.5±0.6 vs. 2.0±0.3 cm (middle LR; P<0.05) vs. 0.7±0.2 cm (upper LR; P<0.01). After RT, tumor mobility was significantly reduced in the lower LR (P<0.01) and in T2 tumor patients (P<0.05). VC showed no significant changes. dMRI is capable of monitoring changes in lung motion that were not suspected from spirometry. This might make the treatment of side effects possible at a very early stage. Changes of lung motion and tumor mobility are highly dependent on the tumor localization and tumor diameter. (orig.)

  19. Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Plathow, Christian [Eberhard-Karls University Tuebingen, Department of Diagnostic Radiology, Tuebingen (Germany); German Cancer Research Center, Department of Radiology, Heidelberg (Germany); Hof, Holger; Kuhn, Sabine [University of Heidelberg, Department of Radiation Therapy, Clinic for Thoracic Diseases, Heidelberg (Germany); Puderbach, Michael; Ley, Sebastian; Biederer, Juergen; Kauczor, Hans-Ulrich [German Cancer Research Center, Department of Radiology, Heidelberg (Germany); Claussen, Claus D.; Schaefer, Juergen [Eberhard-Karls University Tuebingen, Department of Diagnostic Radiology, Tuebingen (Germany); Huber, Peter E. [University of Heidelberg, Department of Radiation Therapy, Clinic for Thoracic Diseases, Heidelberg (Germany); German Cancer Research Center, Department of Radiation Oncology, Heidelberg (Germany); Tuengerthal, Siegfried [University of Heidelberg, Department of Radiology, Heidelberg (Germany)

    2006-09-15

    A frequent side effect after radiotherapy of lung tumors is a decrease of pulmonary function accompanied by dyspnea due to developing lung fibrosis. The aim of this study was to monitor lung motion as a correlate of pulmonary function and intrathoracic tumor mobility before and after radiotherapy (RT) using dynamic MRI (dMRI). Thirty-five patients with stage I non-small-cell lung carcinoma were examined using dMRI (trueFISP; three images/s). Tumors were divided into T1 and T2 tumors of the upper, middle and lower lung region (LR). Maximum craniocaudal (CC) lung dimensions and tumor mobility in three dimensions were monitored. Vital capacity (VC) was measured and correlated using spirometry. Before RT, the maximum CC motion of the tumor-bearing hemithorax was 5.2{+-}0.9 cm if the tumor was located in the lower LR (middle LR: 5.5{+-}0.8 cm; upper LR: 6.0{+-}0.6 cm). After RT, lung motion was significantly reduced in the lower LR (P<0.05). Before RT, the maximum CC tumor mobility was significantly higher in tumors of the lower LR 2.5{+-}0.6 vs. 2.0{+-}0.3 cm (middle LR; P<0.05) vs. 0.7{+-}0.2 cm (upper LR; P<0.01). After RT, tumor mobility was significantly reduced in the lower LR (P<0.01) and in T2 tumor patients (P<0.05). VC showed no significant changes. dMRI is capable of monitoring changes in lung motion that were not suspected from spirometry. This might make the treatment of side effects possible at a very early stage. Changes of lung motion and tumor mobility are highly dependent on the tumor localization and tumor diameter. (orig.)

  20. Gait pattern of heifers before and after claw trimming: a high-speed cinematographic study on a treadmill.

    Science.gov (United States)

    Meyer, S W; Weishaupt, M A; Nuss, K A

    2007-02-01

    The manner in which the claws contacted the ground at the walk was evaluated in 18 healthy heifers. The animals were filmed before and after claw trimming while walking on a treadmill using high-speed cinematography (500 frames/s). For each limb, 4 consecutive steps were recorded from a side and a frontal plane. The objectives of the study were to evaluate 1) the order of claw contact with the treadmill surface, 2) the initial claw contact area, and 3) the effect of trimming on claw contact patterns. The heifers placed their front feet on the ground in a plane sagittal to the shoulders, whereas the hind feet were advanced more toward the median plane. Before trimming, the lateral claws contacted the ground before the medial in 83% of front and 100% of hind limbs. Trimming changed the percentage to 92% in the front and to 97% in the hind limbs. The percentage with which the heel of the lateral claws became the region of initial contact with the ground increased from 47 to 64% in the front feet and from 50 to 78% in the hind feet. In the medial claws of the forelimbs, claw trimming shifted the region of initial contact from the toe to the abaxial wall and heel. In the hind limbs, the main region of initial contact of the medial claws became the abaxial wall. Weight bearing by the medial claw became visibly apparent only during the midstance, propulsion, and push-off phases. "Heel first" contact of the lateral claws in the front and hind limbs may be the normal gait pattern in cattle. On hard surfaces, this pattern may lead to overload and predispose to disease, especially in the hind limbs. PMID:17235142

  1. Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment

    Institute of Scientific and Technical Information of China (English)

    Yao-Pan Wu; Pei-Qiang Cai; Li Tian; Jie-Hua Xu; Richard Alan Mitteer Jr; Yi Fan; Zhenfeng Zhang

    2015-01-01

    Introduction:Patients with nasopharyngeal carcinoma (NPC) sporadically develop abnormal adenoids. Nasopharyngeal adenoids are usually included in the gross tumor volume (GTV) but may have different therapeutic responses than tumor tissue. Therefore, distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy. We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging (MRI). Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed. The features of the adenoid masses, including location, striped appearance, size, interface, symmetry/asymmetry, and cysts, were evaluated. Treatment response were scored according to the World Health Organization guidelines. Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment. In these 36 cases, the average GTVs including and excluding the uninvolved adenoids were 19.8 cm3 and 14.8 cm3, respectively. The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%. Stable disease in the adenoids was identified in 27 (96.4%) of 28 patients after neoadjuvant chemotherapy, while NPC clearly regressed. Partial adenoid responses were identified in 33 (82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy, whereas complete tumor responses were achieved in all patients. Six months after treatment, the adenoids continued to atrophy but did not disappear, and tumor recurrence was not found. Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy. These findings contribute to better delineating the GTV of NPC, based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and

  2. Spectral analysis of the electromyograph of the erector spinae muscle before and after a dynamic manual load-lifting test

    Directory of Open Access Journals (Sweden)

    Cardozo A.C.

    2004-01-01

    Full Text Available The aim of the present study was to assess the spectral behavior of the erector spinae muscle during isometric contractions performed before and after a dynamic manual load-lifting test carried out by the trunk in order to determine the capacity of muscle to perform this task. Nine healthy female students participated in the experiment. Their average age, height, and body mass (± SD were 20 ± 1 years, 1.6 ± 0.03 m, and 53 ± 4 kg, respectively. The development of muscle fatigue was assessed by spectral analysis (median frequency and root mean square with time. The test consisted of repeated bending movements from the trunk, starting from a 45º angle of flexion, with the application of approximately 15, 25 and 50% of maximum individual load, to the stand up position. The protocol used proved to be more reliable with loads exceeding 50% of the maximum for the identification of muscle fatigue by electromyography as a function of time. Most of the volunteers showed an increase in root mean square versus time on both the right (N = 7 and the left (N = 6 side, indicating a tendency to become fatigued. With respect to the changes in median frequency of the electromyographic signal, the loads used in this study had no significant effect on either the right or the left side of the erector spinae muscle at this frequency, suggesting that a higher amount and percentage of loads would produce more substantial results in the study of isotonic contractions.

  3. Particle morphology and mineral structure of heavy metal-contaminated kaolin soil before and after electrokinetic remediation.

    Science.gov (United States)

    Roach, Nicole; Reddy, Krishna R; Al-Hamdan, Ashraf Z

    2009-06-15

    This study aims to characterize the physical distribution of heavy metals in kaolin soil and the chemical and structural changes in kaolinite minerals that result from electrokinetic remediation. Three bench-scale electrokinetic experiments were conducted on kaolin that was spiked with Cr(VI) alone, Ni (II) alone, and a combination of Cr(VI), Ni(II) and Cd(II) under a constant electric potential of 1VDC/cm for a total duration of 4 days. Transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) analyses were performed on the soil samples before and after electrokinetic remediation. Results showed that the heavy metal contaminant distribution in the soil samples was not observable using TEM and EDX. EDX detected nickel and chromium on some kaolinite particles and titanium-rich, high-contrast particles, but no separate phases containing the metal contaminants were detected. Small amounts of heavy metal contaminants that were detected by EDX in the absence of a visible phase suggest that ions are adsorbed to kaolinite particle surfaces as a thin coating. There was also no clear correlation between semiquantitative analysis of EDX spectra and measured total metal concentrations, which may be attributed to low heavy metal concentrations and small size of samples used. X-ray diffraction analyses were aimed to detect any structural changes in kaolinite minerals resulting from EK. The diffraction patterns showed a decrease in peak height with decreasing soil pH value, which indicates possible dissolution of kaolinite minerals during electrokinetic remediation. Overall this study showed that the changes in particle morphology were found to be insignificant, but a relationship was found between the crystallinity of kaolin and the pH changes induced by the applied electric potential. PMID:19013716

  4. Particle morphology and mineral structure of heavy metal-contaminated kaolin soil before and after electrokinetic remediation

    Energy Technology Data Exchange (ETDEWEB)

    Roach, Nicole; Reddy, Krishna R. [Department of Civil and Materials Engineering, University of Illinois at Chicago, 842 West Taylor Street, Chicago, IL 60607 (United States); Al-Hamdan, Ashraf Z., E-mail: alhamdan@eng.uah.edu [Department of Civil and Environmental Engineering, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899 (United States)

    2009-06-15

    This study aims to characterize the physical distribution of heavy metals in kaolin soil and the chemical and structural changes in kaolinite minerals that result from electrokinetic remediation. Three bench-scale electrokinetic experiments were conducted on kaolin that was spiked with Cr(VI) alone, Ni (II) alone, and a combination of Cr(VI), Ni(II) and Cd(II) under a constant electric potential of 1 VDC/cm for a total duration of 4 days. Transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) analyses were performed on the soil samples before and after electrokinetic remediation. Results showed that the heavy metal contaminant distribution in the soil samples was not observable using TEM and EDX. EDX detected nickel and chromium on some kaolinite particles and titanium-rich, high-contrast particles, but no separate phases containing the metal contaminants were detected. Small amounts of heavy metal contaminants that were detected by EDX in the absence of a visible phase suggest that ions are adsorbed to kaolinite particle surfaces as a thin coating. There was also no clear correlation between semiquantitative analysis of EDX spectra and measured total metal concentrations, which may be attributed to low heavy metal concentrations and small size of samples used. X-ray diffraction analyses were aimed to detect any structural changes in kaolinite minerals resulting from EK. The diffraction patterns showed a decrease in peak height with decreasing soil pH value, which indicates possible dissolution of kaolinite minerals during electrokinetic remediation. Overall this study showed that the changes in particle morphology were found to be insignificant, but a relationship was found between the crystallinity of kaolin and the pH changes induced by the applied electric potential.

  5. Assessment of Anterior Segment Measurements with Swept Source Optical Coherence Tomography before and after Ab Interno Trabeculotomy (Trabectome) Surgery

    Science.gov (United States)

    Huang, Ping

    2016-01-01

    Purpose. To compare the changes of anterior segment parameters, assessed by swept source anterior segment optical coherence tomography (AS-OCT) after combined Trabectome-cataract surgery and Trabectome-only surgery in open angle glaucoma patients. Methods. Thirty-eight eyes of 24 patients with open angle glaucoma were scanned with swept source AS-OCT before and 4 weeks after combined Trabectome-cataract or Trabectome-only surgery. Intraocular pressure, number of medications, and AS-OCT parameters, such as angle opening distance at 500 and 750 μm from the scleral spur (AOD500 and AOD750), trabecular-iris space area at 500 and 750 mm2 (TISA500, TISA750), angle recess area at 500 and 750 mm2 (ARA500, ARA750), trabecular iris angle (TIA), anterior chamber depth (ACD), anterior chamber width (ACW), and anterior chamber volume (ACV), were obtained before the surgery. These parameters were compared to evaluate whether the outcome of the surgery differed among the patients after the surgery. The width of the trabecular cleft was also measured for both groups. Results. The reduction of IOP and number of medications was found to be statistically significant in both groups (p ACV, and angle parameters such as AOD 500/750, TISA 500/750, ARA 500/750, and TIA500 showed significantly greater changes from the preoperative values to postoperative 1st month values in combined Trabectome-cataract surgery group (p 0.05). There was no statistically significant difference between two groups for the width of the trabecular cleft (p = 0.7). Conclusion. Anterior chamber angle parameters measured with swept source AS-OCT may be useful for evaluating glaucoma patients before and after Trabectome surgery with or without cataract surgery. PMID:27795855

  6. Knee cartilage quality assessed with dGEMRIC in rheumatoid arthritis patients before and after treatment with a TNF inhibitor

    Energy Technology Data Exchange (ETDEWEB)

    Tiderius, Carl Johan; Dahlberg, Leif E. (Dept. of Orthopedics, Malmoe Univ. Hospital, Lund Univ., Malmoe (Sweden)), e-mail: carl-johan.tiderius@skane.se; Svensson, Jonas (Dept. of Radiation Physics, Malmoe Univ. Hospital, Lund Univ., Malmoe (Sweden)); Sandin, Joakim; Jacobsson, Lennart (Dept. of Rheumatology, Malmoe Univ. Hospital, Lund Univ., Malmoe (Sweden))

    2010-11-15

    Background: TNF-a inhibitors are potent anti-inflammatory drugs that have revolutionized the treatment of rheumatoid arthritis (RA). Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a non-invasive method to study cartilage quality, in particular the glycosaminoglycan (GAG) content. Purpose: To evaluate knee cartilage quality before and after treatment with a TNF-a inhibitor (infliximab) in patients with RA using dGEMRIC and to study clinical parameters and serum cartilage oligomeric protein (COMP) after the same treatment. Material and Methods: Seven patients with chronic RA received infusions of 3 mg/kg infliximab at weeks 0, 2, 6, 14, and 22. Clinical examination, serum COMP level, and dGEMRIC scans (1.5 T) were performed at baseline and after 7 months. The dGEMRIC index (ms), reflecting cartilage GAG content, was calculated using an inversion recovery sequence in the femoral weight-bearing cartilage. Seven years after treatment, charts were reviewed regarding joint replacement surgery (T{sub k}A). Results: Clinical parameters showed an improvement for all patients after the 7-month treatment period. Serum COMP decreased from 13+-4.5 to 11+-3.4 (mug, mean +- SD) mug/ml (P<0.05). The dGEMRIC index was lower at follow-up than at baseline, 332+-85 and 382+-69 (ms, mean +- SD), respectively (P<0.05), indicating loss of GAG. The two patients with the lowest dGEMRIC index had received a T{sub k}A 7 years after treatment. Conclusion: This longitudinal study indicates a substantial GAG loss from the knee cartilage matrix in patients with chronic RA. Treatment with infliximab does not seem to protect the cartilage from further deterioration despite improvements in clinical parameters and decreased serum COMP

  7. Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study

    Institute of Scientific and Technical Information of China (English)

    Zeyu Xie; Minghua Zhuang; Lan Lin; Hongwu Xu; Linxing Chen; Lina Hu

    2007-01-01

    . Hyperbaric oxygenation took an hour for once a day and 10 times were regarded as a course. Venous blood was collected before treatment and on the next day of the first course end. Content of C-reactive protein in plasma was measured with immune turbidimetry in hyperbaric oxygenation group; in addition, content of C-reactive protein in plasma was directly measured with the same method at the corresponding time in the control group. If the content was less or equal to 8 mg/L, it was regarded as normal value. Effects of the two groups were evaluated based on Glasgow Coma Score before and after treatment. MAIN OUTCOME MEASURES: Content of plasma C-reactive protein and Glasgow Coma Score in the two groups before and after treatment.RESULTS: All 60 patients were involved in the final analysis. Protein: The two contents were obviously higher than normal value after craniocerebral injury. There was no significant difference in the two groups before treatment (P > 0.05), but both contents were decreased after treatment, and there was significant difference between HBOT group and control group after treatment (t =4.756, P < 0.01). In addition, there was significant difference in hyperbaric oxygen therapy group before and after treatment (t =5.236, P < 0.01). Glasgow Coma Score: There was no significant difference in the two groups before treatment (P > 0.05), but scores were increased in both groups after treatment (t =9.92, 2.51, P < 0.01, 0.05); on the other hand, therefore, there was significant difference between the two groups after treatment (t=9.21, P < 0.01).CONCLUSION: Hyperbaric oxygenation can remarkably decrease content of plasma C-reactive protein in patients with craniocerebral injury at the phase of stress.

  8. Changes in the latencies of visual-evoked potentials in people undergoing tennis training Dynamic comparison before and after 8 weeks training

    Institute of Scientific and Technical Information of China (English)

    Jingguo Zhao; Shujuan Pang

    2008-01-01

    BACKGROUND: Some previous studies have shown that exercise is an important factor that affects the latencies of visual-evoked potentials (VEPs).OBJECTIVE: To investigate the effects of spending a period of time undergoing tennis training on the latencies of VEPs by comparing the latencies of VEPs before tennis training with those after 8 weeks of tennis training.DESIGN, TIME AND SETTING: The non-randomly concurrent controlled experiment was performed in the Department of Human Movement Sciences, Physical Education College, Shandong Normal University from April to June 2007.PARTICIPANTS: In total, 45 healthy volunteers from Shandong Normal University were selected as subjects, including 31 students majoring in physical education (11 males and 5 females participated in the tennis training plan for 8 weeks), and 14 students from other subjects. Informed consent was obtained. According to whether they were majoring in physical education or not, and whether or not they took part in tennis training, the students were divided into 3 groups: a tennis group of physical education students (n =16), a non-tennis group of physical education students (n =15) and a non-tennis group of non-physical education students (n =14). METHODS: The subjects in the tennis group took part in a regular tennis training plan of 2 hours a day and 3 days per week, for 8 weeks, while the subjects in two non-tennis groups were not in the tennis training plan. The NDI-200 neural electricity tester (Shanghai Haishen Medical Electronic Instrument Co., Ltd.) was used to measure VEPs before and after the experiment in all three groups, and to compare the latencies of VEPs recorded before training with those recorded after training.MAIN OUTCOME MEASURES: Comparison of the changes in latencies of VEPs before and after 8 weeks of tennis training.RESULTS: All 45 subjects finished the test and datas from all were included in the statistical analysis. There were no significant differences among all the three

  9. Crohn's Disease Evaluated with Magnetic Resonance Enteroclysis: Diagnostic Performance of Experienced and Inexperienced Readers before and after Training

    International Nuclear Information System (INIS)

    Background: Magnetic resonance enteroclysis (MRE) is suggested to become the preferred radiological method in small-bowel Crohn's disease (CD). However, the performance of inexperienced readers may influence the diagnostic value of the method and has not been previously investigated. Purpose: To compare readings of MRE in small-bowel CD performed by experienced and inexperienced readers before and after training.Material and Methods: One experienced radiologist (observer 1) and two trainees (observers 2 and 3) reviewed 60 MRE examinations. A second reading was performed after training. Bowel wall thickness (BWT), ulcers (BWU), stenosis (BWS), fistulas (FIS), and abscesses (ABS) were evaluated. A reference standard based on clinical records was established. Results: BWT in the terminal ileum was evaluated with high diagnostic performance (sensitivity: observer 1, 83%; observer 2, 72%; observer 3, 78%). Only BWU was diagnosed with a higher sensitivity by observer 1 (78% vs. 33% and 39%, respectively; P=0.02). False-positive findings for BWT in the jejunum (observer 2: 7; observer 3: 4) and fistulas and abscesses (observer 2: 11/5; observer 3: 5/4) were made by the trainees. Interobserver agreement in the jejunum was poor (observer 1/observer 2: κ=0.23; observer 1/observer 3: κ=-0.03) and in the ileum good (observer 1/observer 2: κ=0.78; observer 1/observer 3: κ=0.73). After training, evaluation of BWU (observer 2: 56%, P=0.22; observer 3: 44%, P=0.03), BWT (observer 2: 2; observer 3: 2), and interobserver agreement in the jejunum improved (observer 1/observer 2: κ=0.66; observer 1/observer 3: κ=0.66). However, the number of diagnosed fistulas and abscesses remained high. Conclusion: Before training, most findings of Crohn's disease in the terminal ileum were evaluated with high diagnostic performance by all readers. However, the inexperienced readers evaluated BWU with a low sensitivity and overestimated the number of FIS, number of ABS, and increased BWT in

  10. Lipid profile and levels of homocysteine, leptin, fibrinogen and C-reactive protein in hyperthyroid patients before and after treatment

    Directory of Open Access Journals (Sweden)

    Emine Sütken

    2010-03-01

    Full Text Available Objectives: The present study was carried out to determine whether thyroid hormones affect lipid profile and levels of erithrocyte sedimentation rate (ESR, serum total homocysteine (t-hcy, leptin, fibrinogen, C-reactive protein (CRP in patients with hyperthyroidism.Materials and methods: This study was carried out on 23 hyperthroid subjects (3 men / 20 women, mean age 41.8 ± 2.4 years. Serum levels of homocysteine, leptin, fibrinogen, CRP, total cholesterol (TC, high-density lipoprotein cholesterol (HDL-C, low-density lipoprotein cholesterol (LDL-C and ESR were measured and body mass index (BMI were calculated before and after treatment of hyperthyroidism.Results: Pretreatment t-hcy, TC, LDL-C, HDL-C levels and BMI of patients were significantly lower than those of the post-treatment (p<0.001, for each variable. However, fibrinogen and ESR decreased after the treatment (p<0.001 and p<0.05, respectively. There were no differences in leptin and CRP levels between pre- and post-treatment periods. Pre and post treatment TC and LDL-C levels were negatively correlated with free triiodothyronine (fT3 levels (r=-0.588, p<0.01; r=-0.534, p<0.01; r=-0.543, p<0.01 and r =-0.653, p<0.01, respectively. Pre-treatment HDL-C was inversely correlated with TSH (r=-0.423, p<0.05. Pre-post- treatment LDL-C was negatively correlated with free thyroxine (fT4 levels (r=-0.536, p<0.001 and r=- 0.422, p<0.05 respectively. Pre-treatment TC was inversely correlated with fT4 (r=-0.590, p<0.01.Conclusion: Hyperthyroidism is associated with high plasma fibrinogen and ESR levels. Elevated plasma fibrinogen and ESR levels may be a possible explanation for the high cardiovascular morbidity among hyperthyroidic subjects. These changes may reflect low-grade inflammation or disturbances in coagulation in hyperthyroidism.

  11. Providing education on evidence-based practice improved knowledge but did not change behaviour: a before and after study

    Directory of Open Access Journals (Sweden)

    Lovarini Meryl

    2005-12-01

    Full Text Available Abstract Background Many health professionals lack the skills to find and appraise published research. This lack of skills and associated knowledge needs to be addressed, and practice habits need to change, for evidence-based practice to occur. The aim of this before and after study was to evaluate the effect of a multifaceted intervention on the knowledge, skills, attitudes and behaviour of allied health professionals. Methods 114 self-selected occupational therapists were recruited. The intervention included a 2-day workshop combined with outreach support for eight months. Support involved email and telephone contact and a workplace visit. Measures were collected at baseline, post-workshop, and eight months later. The primary outcome was knowledge, measured using the Adapted Fresno Test of Evidence-Based Practice (total score 0 to 156. Secondary outcomes were attitude to evidence-based practice (% reporting improved skills and confidence; % reporting barriers, and behaviour measured using an activity diary (% engaging/not engaging in search and appraisal activities, and assignment completion. Results Post-workshop, there were significant gains in knowledge which were maintained at follow-up. The mean difference in the Adapted Fresno Test total score was 20.6 points (95% CI, 15.6 to 25.5. The change from post-workshop to follow-up was small and non-significant (mean difference 1.2 points, 95% CI, -6.0 to 8.5. Fewer participants reported lack of searching and appraisal skills as barriers to evidence-based practice over time (searching = 61%, 53%, 24%; appraisal 60%, 65%, 41%. These differences were statistically significant (p = 0.0001 and 0.010 respectively. Behaviour changed little. Pre-workshop, 6% engaged in critical appraisal increasing to 18% post-workshop and 18% at follow-up. Nearly two thirds (60% were not reading any research literature at follow-up. Twenty-three participants (20.2% completed their assignment. Conclusion Evidence

  12. Measurement of energy expenditure in overweight men and women using [C-14]-bicarbonate-urea before and after weight loss

    International Nuclear Information System (INIS)

    Full text: Many studies have demonstrated significant declines in 24-hour energy expenditure (TEE) measured by whole body calorimetry with either the process of weight loss or the maintenance of reduced body weight. The aims of this study were to determine the effect of weight loss and two weeks of weight maintenance on TEE using [14C]-bicarbonate-urea, Eleven subjects (6 males, 5 females), mean (±SE) age 50 ± 3 years, BMI 34.1 ± 2.1 kg/m2 and body fat 38.7 ± 3% were studied before and after a decrease in body weight of > 8% over a period of 8 weeks, followed by two weeks of weight maintenance. Weight loss was induced using the combination of Modifast and one small meal a day (∼3.34 MJ/day). Body composition (DEXA), resting energy expenditure (REE) and the thermic effect of a 2.7 MJ test meal (TEF) were measured in addition to TEE at week 2 and again at week 12. Diet was assessed using diaries and physical activity energy expenditure (PAEE) was calculated from the equation: 0.9 x TEE-REE, which assumes that 10% of TEE is accounted for by the TEE. Body weight decreased by 11.8 ± 1.0% from week 2 to 10, and remained stable thereafter. Total fat mass, abdominal fat mass and lean mass decreased by 19.7 ± 1.8%, 21.8 ± 2.3% and 6.0 ± 1.1 % respectively. At week 12, REE decreased by 5.7 ± 1.3% (p < 0.002). The decreases in TEF (13.3 ± 13.7%), PAEE (31 ± 57.5%) and TEE (0.18 + 3.68%) were not significant. There was a significant relationship between the change in REE and overall body weight (p < 0.026) but not lean mass. It is concluded that in free-living subjects, after weight loss and two weeks of weight maintenance, REE but not TEE decreases, although there is substantial variability between individuals.Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  13. Indoor air quality in a bar/restaurant before and after the smoking ban in Athens, Greece.

    Science.gov (United States)

    Konstantopoulou, Sophia S; Behrakis, Panagiotis K; Lazaris, Andreas C; Nicolopoulou-Stamati, Polyxeni

    2014-04-01

    In this study we compared indoor air pollutant concentrations in a bar/restaurant in Greece before and after the enactment of a smoking ban legislation of 2008. This was done to investigate whether the separation of the venue into smoking and non-smoking areas will have an impact on workers and customers from secondhand smoke (SHS) exposure (null hypothesis). The study was completed within an 8-month period beginning in March 2010 and ending on November 2010. We compared the average of the measured PM0.1 concentrations in the smoking zones between the pre-ban and post-ban periods. Overall reduction in the number of particles was 18% between pre-ban and post-ban periods. The mean of the 36 total CO2 measurements for the pre- and the post-ban period was 611ppm. We calculated the ventilation rates per occupant (Vo in l/s/occ) and found it to be higher in the post-ban period (19.4l/s/occ), thus complying with the ASHARAE standard for Vo of 15l/s/occ at maximum occupancy, than in the pre-ban period (10.7l/s/occ). The mean of the 36 total CO measurements for the pre-ban period was 2 ppm. CO measurements in the post-ban period were less than the detection limit of 1 ppm. Emissions of nitrogen dioxide and formaldehyde weren't detected in any of the zones. It was observed there was about 50% distribution of pollutants from the smoking zones to the smoke-free zones. The smoking ban effect on the occupancy levels was initially reduced by 16%, but based on other similar studies this transition period will be followed by an increase in the occupancy. Passive smoking and associated risks were significantly reduced but not totally eliminated, indicating the need for stronger enforcement or complete partition between smoking and non-smoking areas. PMID:24463032

  14. Tuberculosis, before and after Antiretroviral Therapy among HIV-Infected Children in Nigeria: What Are the Risk Factors?

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    Emmanuel A Anígilájé

    Full Text Available In Nigeria, there is a dearth of pediatric data on the risk factors associated with tuberculosis (TB, before and after antiretroviral therapy (ART.A retrospective observational cohort study, between October 2010 and December 2013, at the Federal Medical Centre, Makurdi, Nigeria. TB was noted among children less than 15 years of age at ART enrolment (prevalent TB-PrevTB, within 6 months (early incident tuberculosis-EITB and after 6 months (late incident tuberculosis-LITB of a 12-month follow-up on ART. Potential risk factors for PrevTB and incident TB were assessed using the multivariate logistic and Cox regression models respectively.Among 368 HIV-1 infected children, PrevTB was diagnosed in 73 children (19.8%. Twenty-eight EITB cases were diagnosed among 278 children over 132 person-years (py with an EITB rate of 21.2/100 py. Twelve LITB cases were seen among 224 children over 221.9 py with a LITB rate of 5.4/100 py. A significant reduction in the incidence rates of TB was found over time (75%, p˂ 0.001. Young age of children (12-35 months, aOR; 24, 95% CI; 4.1-146.6, p ˂ 0.001; 36-59 months, aOR;21, 95%CI;4.0-114.3, p ˂ 0.001; history of TB in children (aOR; 29, 95% CI; 7.3-119.4, P˂ 0.001; severe immunosuppression (aOR;38, 95% CI;12-123.2,p ˂ 0.001; oropharyngeal candidiasis (aOR;3.3, 95% CI; 1.4-8.0, p = 0.009 and sepsis (aOR; 3.2, 95% CI;1.0-9.6, p = 0.043 increased the risk of PrevTB. Urban residency was protective against EITB (aHR; 0.1, 95% CI; 0.0-0.4, p = 0.001. Virological failure (aHR; 4.7, 95% CI; 1.3-16.5, p ˂ 0.001 and sepsis (aHR; 26, 95% CI; 5.3-131.9, p ˂ 0.001 increased the risk of LITB.In our cohort of HIV-infected children, a significant reduction in cases of incident TB was seen following a 12-month use of ART. After ART initiation, TB screening should be optimized among children of rural residency, children with sepsis, and those with poor virological response to ART.

  15. Presence of depression and anxiety before and after coronary artery bypass graft surgery and their relationship to age

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    Herzog Michael

    2007-09-01

    Full Text Available Abstract Background Scientific literature on depression and anxiety in patients with coronary heart disease (CHD consistently reports data of elevated anxiety and depression scores indicating clinically relevant quantities of these psychopathological conditions. Depression is considered to be a risk factor for the development of CHD and deteriorates the outcome after cardiac rehabilitation efforts. The aim of our study was to evaluate the presence of clinically relevant anxiety and depression in patients before and after coronary artery bypass grafting (CABG. Additionally we evaluated their relationship to age because of the increasing number of elderly patients undergoing CABG surgery. Methods One hundred and forty-two consecutive patients who underwent CABG in our hospital were asked to fill in the "Hospital Anxiety and Depression Scale – German Version (HADS" to measure depression and anxiety scores two days before and ten days after CABG surgery. Differences between these pre- and post-surgical scores were then calculated as means for changes, and the amount of elevated scores were appraised. In order to investigate the relationship between age and anxiety and depression, respectively, Spearman correlations between age and the difference scores were calculated. In addition, ANOVA procedures with the factor "age group" and McNemar tests were calculated. Therefore the sample was divided into four equally sized age groups. Results 25.8% of the patients were clinically depressed before and 17.5% after surgery; 34.0% of the patients were clinically anxious before and 24.7% after surgery. This overall change is not significant. We found a significant negative correlation between age and the difference between the two time points for anxiety (Spearman rho = -.218; p = 0.03, but not for depression (Spearman rho = -.128; p = 0.21. ANOVA and McNemar-Tests revealed that anxiety scores and the number of patients high in anxiety declined statistically

  16. Young children's probability of dying before and after their mother's death: a rural South African population-based surveillance study.

    Directory of Open Access Journals (Sweden)

    Samuel J Clark

    Full Text Available BACKGROUND: There is evidence that a young child's risk of dying increases following the mother's death, but little is known about the risk when the mother becomes very ill prior to her death. We hypothesized that children would be more likely to die during the period several months before their mother's death, as well as for several months after her death. Therefore we investigated the relationship between young children's likelihood of dying and the timing of their mother's death and, in particular, the existence of a critical period of increased risk. METHODS AND FINDINGS: Data from a health and socio-demographic surveillance system in rural South Africa were collected on children 0-5 y of age from 1 January 1994 to 31 December 2008. Discrete time survival analysis was used to estimate children's probability of dying before and after their mother's death, accounting for moderators. 1,244 children (3% of sample died from 1994 to 2008. The probability of child death began to rise 6-11 mo prior to the mother's death and increased markedly during the 2 mo immediately before the month of her death (odds ratio [OR] 7.1 [95% CI 3.9-12.7], in the month of her death (OR 12.6 [6.2-25.3], and during the 2 mo following her death (OR 7.0 [3.2-15.6]. This increase in the probability of dying was more pronounced for children whose mothers died of AIDS or tuberculosis compared to other causes of death, but the pattern remained for causes unrelated to AIDS/tuberculosis. Infants aged 0-6 mo at the time of their mother's death were nine times more likely to die than children aged 2-5 y. The limitations of the study included the lack of knowledge about precisely when a very ill mother will die, a lack of information about child nutrition and care, and the diagnosis of AIDS deaths by verbal autopsy rather than serostatus. CONCLUSIONS: Young children in lower income settings are more likely to die not only after their mother's death but also in the months before

  17. Innovative psycho-educational program to prevent common postpartum mental disorders in primiparous women: a before and after controlled study

    Directory of Open Access Journals (Sweden)

    Rowe Heather J

    2010-07-01

    Full Text Available Abstract Background Universal interventions to prevent postnatal mental disorders in women have had limited success, perhaps because they were insufficiently theorised, not gender-informed and overlooked relevant risk factors. This study aimed to determine whether an innovative brief psycho-educational program for mothers, fathers and first newborns, which addressed salient learning needs about infant behaviour management and adjustment tasks in the intimate partner relationship, prevented postpartum mental health problems in primiparous women. Methods A before and after controlled study was conducted in primary care in seven local government areas in Victoria, Australia. English-speaking couples with one-week old infants were invited consecutively to participate by the maternal and child health nurse at the universal first home visit. Two groups were recruited and followed sequentially: both completed telephone interviews at four weeks and six months postpartum and received standard health care. Intervention group participants were also invited to attend a half-day program with up to five couples and one month old infants, facilitated by trained, supervised nurses. The main outcome was any Composite International Diagnostic Interview (CIDI diagnosis of Depression or Anxiety or Adjustment Disorder with Depressed Mood, Anxiety, or Mixed Anxiety and Depressed Mood in the first six months postpartum. Factors associated with the outcome were established by logistic regression controlling for potential confounders and analysis was by intention to treat. Results In total 399/646 (62% women were recruited; 210 received only standard care and 189 were also offered the intervention; 364 (91% were retained at follow up six months postpartum. In women without a psychiatric history (232/364; 64%, 36/125 (29% were diagnosed with Depression or Anxiety or Adjustment Disorder with Depressed Mood, Anxiety, or Mixed Anxiety and Depressed Mood in the control group

  18. Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France

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    Cohen Robert

    2012-03-01

    Full Text Available Abstract Background Several studies have investigated the impact of 7-valent pneumococcal conjugate vaccine (PCV7 on pneumococcal (Sp and staphylococcal (Sa nasopharyngeal (NP carriage. Few have investigated the impact on Haemophilus influenzae (Hi and Moraxella catarrhalis (Mc carriage. We aimed to compare the NP carriage rates in young children with acute otitis media (AOM before and after PCV7 implementation in France. Methods Prior to PCV7 implementation, we performed 4 successive randomized trials with NP samples. These studies compared several antibiotic regimens for treating AOM in young children (6 to 30 months. After PCV7 implementation, to assess the impact of the vaccination program on NP flora, young children with AOM were enrolled in a prospective surveillance study. In each study, we obtained an NP sample to analyze the carriage rates of Sp, Hi, Mc and Sa and the factors influencing the carriage. Standardized history and physical examination findings were recorded; the methods used for NP swabs (sampling and cultures were the same in all studies. Results We enrolled 4,405 children (mean age 13.9 months, median 12.8. Among the 2,598 children enrolled after PCV7 implementation, 98.3% were vaccinated with PCV7. In comparing the pre- and post-PCV7 periods, we found a slight but non-significant decrease in carriage rates of pneumococcus (AOR = 0.85 [0.69;1.05], H. influenzae (AOR = 0.89 [0.73;1.09] and S. aureus (AOR = 0.92 [0.70;1.19]. By contrast, the carriage rate of M. catarrhalis increased slightly but not significantly between the 2 periods (AOR = 1.08 [0.95;1.2]. Among Sp carriers, the proportion of PCV7 vaccine types decreased from 66.6% to 10.7% (P Conclusion The carriage rates of otopathogen species (Sp, Hi, Mc and Sa did not significantly change in children with AOM after PCV7 implementation in France. However, we observed significant changes in carriage rates of PCV7 vaccine serotypes and penicillin non-susceptible Sp.

  19. Assessment of left ventricular torsion in patients with anterior wall myocardial infarction before and after revascularization using speckle tracking imaging

    Institute of Scientific and Technical Information of China (English)

    HAN Wei; XIE Ming-xing; WANG Xin-fang; L(U) Qing; WANG Jing; ZHANG li; ZHANG Jing

    2008-01-01

    Background Rotation of the left ventricular(LV)apex to the base,or LV torsion,is related to myocardial contractility and structure and has recently been recognized as a sensitive indicator of cardiac performance,but it has been difficult to measure.The recent development of 2-dimensional(2D)speckle tracking imaging(STI)may provide a powerful means of assessing LV torsion.This study was conducted to evaluate the global and regional LV twist in patients with anterior wall myocardial infarction(AMI)disease before and after revascularization by STI.Methods 2D STI was performed in 35 AMI patients before and one month after revascularization,as well as in 32 normal controls.Left ventricular global and regional rotations were obtained at basal and apical short-axis levels;LV torsion was defined as apical rotation relative to the base.The time sequences were normalized to the percentage of systolic and diastolic duration.Results Before revascularization,LV peak regional and global torsion in patients with Aml were significantly reduced as the result of reduced apical and basal rotation relative to those of normal control group(all P<0.001):most significantly in the anterior and anterior-septal regions(P<0.001);one month after revascularization,there were significant changes in peak rotation at either the base or apex relative to pre-revascularization values(all P<0.001).Similarly,peak regional and global LV torsion were increased significantly(all P<0.001).Global torsion inversely correlated with EDV(r=0.605,P=0.028)and ESV(r=-0.638,P=-0.019):and positively correlated with LVEF(r=0.630,P=0.021).tlght relations were also found between torsion and.LV longitudinal and short axis function.Conclusions Systolic torsion was decreased in AMI patients.Revascularization therapy can improve the LV function of the AMI patients.STI has a potential to quantify left ventricular global and segment torsion in patients with AMI,and may make the assessment more available in clinical and

  20. Diet of a catfish before and after damming of the salto caxias reservoir, iguaçu river

    Directory of Open Access Journals (Sweden)

    Rosilene Luciana Delariva

    2007-09-01

    Full Text Available This study evaluated the diet of Pimelodus sp., before and after damming of Salto Caxias, (waterfall in the Iguaçu river, as well spatial and ontogenetic diet shift. Surveys were carried out from March 1997 to February 1998 (before damming and from April 1999 to January 2000 (after damming inside the reservoir and adjacent tributaries. Stomach contents analysis of 682 specimens revealed omnivory with high degree of trophic opportunism to this species. Analysis of variance (three way ANOVA for scores produced from Detrended Correspondence Analysis (DCA yielded a significant interaction between the damming phases and size of the individuals (juveniles and adults (F = 4.68; P = 0.04. After damming, adults exploited mainly fish, whereas the juveniles fed mostly on plants, dipterans larvae and scales at different sites. From significant differences in the ordination among the factors considered, it could be inferred that the diet of Pimelodus sp. was influenced by the formation of the reservoir and this depended on the life stage considered. Position of the sites (feeding grounds did not lead to significant alterations in diet.Esse estudo avaliou a dieta de Pimelodus sp., antes e após o represamento de Salto Caxias, no rio Iguaçu, bem como variações espaciais e ontogenéticas na dieta da espécie. As amostragens foram realizadas antes do represamento (março/97 a fevereiro/98 e no período posterior (abril/99 a janeiro/00, no corpo principal do reservatório e tributários adjacentes. A análise de conteúdos estomacais de 682 exemplares revelou que esta espécie é onívora com elevado oportunismo trófico. Após o represamento, indivíduos adultos exploraram principalmente peixes, enquanto que os juvenis consumiram especialmente plantas, larvas de Diptera e escamas em diferentes locais de coleta. A análise de variância (ANOVA trifatorial aplicada sobre os escores da análise de correspondência com remoção do efeito do arco (DCA, mostrou

  1. A Dual Lung Scan for the Evaluation of Pulmonary Function in Patients with Pulmonary Tuberculosis before and after Treatment

    International Nuclear Information System (INIS)

    In 20 normal cases and 39 pulmonary tuberculosis cases, regional pulmonary arterial blood flow measurement and lung perfusion scans by 131I-Macroaggregated albumin, lung inhalation scans by colloidal 198Au and spirometries by respirometer were done at the Radiological Research Institute. The measured lung function tests were compared and the results were as the following: 1) The normal distribution of pulmonary blood flow was found to be 54.5±2.82% to the right lung and 45.5±2.39% to the left lung. The difference between the right and left pulmonary arterial blood flow was significant statistically (p131I-MAA in patients with pulmonary tuberculosis was as follows: a) In the pretreated minimal pulmonary tuberculosis, the decreased area of pulmonary arterial blood flow was corresponding to the chest roentgenogram, but the decrease of pulmonary arterial blood flow was more extensive than had been expected from the chest roentgenogram in the apparently healed minimal pulmonary tuberculosis. b) In the pretreated moderately advanced pulmonary tuberculosis, the decrease of pulmonary arterial blood flow to the diseased area was corresponding to the chest roentgenogram, but the decrease of pulmonary arterial blood flow was more extensive in the treated moderately advanced pulmonary tuberculosis as in the treated minimal pulmonary tuberculosis. c) Pulmonary arterial blood flow in the patients with far advanced pulmonary tuberculosis both before and after chemotherapy were almost similar to the chest roentgenogram. Especially the decrease of pulmonary arterial blood flow to the cavity was usually greater than had been expected from the chest roentgenogram. 3) Lung inhalation scan by colloidal 198Au in patients with pulmonary tuberculosis was as follows: a) In the minimal pulmonary tuberculosis, lung inhalation scan showed almost similar decrease of radioactivity corresponding to the chest roentgenogram. b) In the moderately advanced pulmonary tuberculosis the decrease of

  2. Venus' upper atmospheric dynamical structure from ground-based observations shortly before and after Venus' inferior conjunction 2009

    Science.gov (United States)

    Sornig, M.; Sonnabend, G.; Stupar, D.; Kroetz, P.; Nakagawa, H.; Mueller-Wodarg, I.

    2013-07-01

    Investigations on the dynamical structure of Venus upper atmosphere were carried out by infrared heterodyne Doppler wind measurements shortly before and after the venusian inferior conjunction on March 27, 2009. The Cologne Tuneable Heterodyne Infrared Spectrometer (THIS) has been installed at the McMath-Pierce Solar Telescope on Kitt Peak, Arizona, USA to detect non-local thermodynamical equilibrium (non-LTE) emission lines of CO2 at a wavelength of 10.5 μm. These solar induced emission lines originate at a pressure level of 1 μbar corresponding to an altitude level of 110 ± 10 km. From the frequency position of the spectral lines we directly derived Doppler winds without any additional information. The high spatial resolution with a field-of-view of 1.6 arcsec compared to an apparent diameter of Venus of 57 arcsec allowed to collect information at different latitudes of the illuminated planet. Line of sight wind velocities between 189 ± 11 m/s and 41 ± 14 m/s were detected along the illuminated evening (western) limb in March and along the bright morning (eastern) limb in April. Single observations at the evening and morning terminator do not show a systematic difference of wind velocities. The measured wind is uniform at low and mid latitudes. In March a lower mean value of 134 ± 1 m/s was found compared to April where we retrieved a value of 141 ± 1 m/s. Poleward of a latitude of 50° we observed a strong decrease in wind speed down to 41 ± 14 m/s. In addition to the pure line of sight wind velocities we used the observing geometry for additional interpretations regarding a global flow from the subsolar point to the antisolar point (SS-AS flow) and a global retrograde superrotational zonal wind (RSZ). The estimations indicate a dominating SS-AS flow with a maximum wind velocity at the terminator of 138 ± 1 m/s at low and mid latitudes. No indication of a global RSZ component was found. Corresponding wind values for the latter yield wind velocities in

  3. Effects of two commercial electronic prescribing systems on prescribing error rates in hospital in-patients: a before and after study.

    Directory of Open Access Journals (Sweden)

    Johanna I Westbrook

    2012-01-01

    Full Text Available BACKGROUND: Considerable investments are being made in commercial electronic prescribing systems (e-prescribing in many countries. Few studies have measured or evaluated their effectiveness at reducing prescribing error rates, and interactions between system design and errors are not well understood, despite increasing concerns regarding new errors associated with system use. This study evaluated the effectiveness of two commercial e-prescribing systems in reducing prescribing error rates and their propensities for introducing new types of error. METHODS AND RESULTS: We conducted a before and after study involving medication chart audit of 3,291 admissions (1,923 at baseline and 1,368 post e-prescribing system at two Australian teaching hospitals. In Hospital A, the Cerner Millennium e-prescribing system was implemented on one ward, and three wards, which did not receive the e-prescribing system, acted as controls. In Hospital B, the iSoft MedChart system was implemented on two wards and we compared before and after error rates. Procedural (e.g., unclear and incomplete prescribing orders and clinical (e.g., wrong dose, wrong drug errors were identified. Prescribing error rates per admission and per 100 patient days; rates of serious errors (5-point severity scale, those ≥3 were categorised as serious by hospital and study period; and rates and categories of postintervention "system-related" errors (where system functionality or design contributed to the error were calculated. Use of an e-prescribing system was associated with a statistically significant reduction in error rates in all three intervention wards (respectively reductions of 66.1% [95% CI 53.9%-78.3%]; 57.5% [33.8%-81.2%]; and 60.5% [48.5%-72.4%]. The use of the system resulted in a decline in errors at Hospital A from 6.25 per admission (95% CI 5.23-7.28 to 2.12 (95% CI 1.71-2.54; p<0.0001 and at Hospital B from 3.62 (95% CI 3.30-3.93 to 1.46 (95% CI 1.20-1.73; p<0.0001. This

  4. Dehydrated citrus pulp alters feedlot performance of crossbred heifers during the receiving period and modulates serum metabolite concentrations before and after an endotoxin challenge.

    Science.gov (United States)

    Cribbs, J T; Bernhard, B C; Young, T R; Jennings, M A; Burdick Sanchez, N C; Carroll, J A; Callaway, T R; Schmidt, T B; Johnson, B J; Rathmann, R J

    2015-12-01

    English × Continental heifers ( = 180) were sourced in 2 loads (219.3 ± 16.0 and 221.4 ± 16.4 kg, respectively) from commercial auction barns to study the effects of feeding dehydrated citrus pulp (DCP) on feedlot performance of newly received heifers. A completely randomized block design was used with BW nested within arrival load and blocked by BW into 3 dietary treatments (36 pens, 5 heifers/pen, 12 blocks, 3 pens/block, and 12 pens/treatment). Treatment diets contained 1) 0% DCP (control diet [CON]), 2) 10% DCP, or 3) 20% DCP on a DM basis. Diets containing DCP were exchanged with steam-flaked corn on a 1:1 basis. Cattle were fed a 63, 73, and 83% concentrate diet from d 0 to 28, d 28 to 42, and d 42 to 56, respectively. Over the 56-d trial period, as the amount of dietary DCP increased, DMI decreased ( = 0.01), ADG decreased ( heifers ( = 22; 307.89 ± 3.32 kg on d 63) were used to evaluate blood metabolite concentrations before and after a lipopolysaccharide (LPS) challenge. On d 63, heifers were fitted with jugular catheters and moved into individual stalls. On d 64, heifers were intravenously challenged with LPS (0.5 μg/kg BW), and blood samples were collected every 0.5 h from -2 to 8 h and at 24 h relative to the LPS challenge (0 h). Serum glucose, serum urea nitrogen (SUN), and NEFA concentrations were determined. Cattle lost less weight at both 24 and 72 h after the LPS challenge with increasing DCP percentage ( heifers following an endotoxin challenge and affected feedlot performance when incorporated in receiving diets in replacement of corn. Future studies will need to address strategies to increase DMI or explore levels of DC