WorldWideScience

Sample records for beam attenuation radiation

  1. Broad beam and narrow beam attenuation in Lipowitz's metal.

    Science.gov (United States)

    el-Khatib, E E; Podgorsak, E B; Pla, C

    1987-01-01

    Attenuation properties of Lipowitz's metal have been studied for narrow and broad beams of cobalt-60 gamma rays and 4-10 MV x-rays. The measured transmitted fraction for geometries used in radiotherapy depends on the field size and depth of measurement. Therefore a calculation of dose for partially attenuated beams based on narrow beam attenuation coefficients can cause large errors in dosimetry. Our simple calculation of transmitted fractions based on primary attenuation and scattered radiation agrees quite well with the measured data for therapeutic geometries. Also given is a table for linear, mass attenuation, and mass energy absorption coefficients of Lipowitz's metal in the photon energy range from 10 keV to 10 MeV. PMID:3104738

  2. Analysis of the variation of the attenuation curve in function of the radiation field size for k Vp X-ray beams using the MCNP-5C code

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R., E-mail: marco@cetea.com.b, E-mail: marfernandes@fmb.unesp.b [Universidade Estadual Paulista Julio de Mesquita Filho (FMB/UNESP), Botucatu, SP (Brazil). Fac. de Medicina; Ribeiro, Victor A.B. [Universidade Estadual Paulista Julio de Mesquita Filho (IBB/UNESP), Botucatu, SP (Brazil). Inst. de Biociencias; Viana, Rodrigo S.S.; Coelho, Talita S. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The paper illustrates the use of the Monte Carlo method, MCNP-5C code, to analyze the attenuation curve behavior of the 50 kVp radiation beam from superficial radiotherapy equipment as Dermopan2 model. The simulations seek to verify the MCNP-5C code performance to study the variation of the attenuation curve - percentage depth dose (PDD) curve - in function of the radiation field dimension used at radiotherapy of skin tumors with 50 kVp X-ray beams. The PDD curve was calculated for six different radiation field sizes with circular geometry of 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 cm in diameter. The radiation source was modeled considering a tungsten target with inclination 30 deg, focal point of 6.5 mm in diameter and energy beam of 50 kVp; the X-ray spectrum was calculated with the MCNP-5C code adopting total filtration (beryllium window of 1 mm and aluminum additional filter of 1 mm). The PDD showed decreasing behavior with the attenuation depth similar what is presented on the literature. There was not significant variation at the PDD values for the radiation field between 1.0 and 4.0 cm in diameter. The differences increased for fields of 5.0 and 6.0 cm and at attenuation depth higher than 1.0 cm. When it is compared the PDD values for fields of 3.0 and 6.0 cm in diameter, it verifies the greater difference (12.6 %) at depth of 5.7 cm, proving the scattered radiation effect. The MCNP-5C code showed as an appropriate procedure to analyze the attenuation curves of the superficial radiotherapy beams. (author)

  3. Modeling transmission and scatter for photon beam attenuators.

    Science.gov (United States)

    Ahnesjö, A; Weber, L; Nilsson, P

    1995-11-01

    The development of treatment planning methods in radiation therapy requires dose calculation methods that are both accurate and general enough to provide a dose per unit monitor setting for a broad variety of fields and beam modifiers. The purpose of this work was to develop models for calculation of scatter and transmission for photon beam attenuators such as compensating filters, wedges, and block trays. The attenuation of the beam is calculated using a spectrum of the beam, and a correction factor based on attenuation measurements. Small angle coherent scatter and electron binding effects on scattering cross sections are considered by use of a correction factor. Quality changes in beam penetrability and energy fluence to dose conversion are modeled by use of the calculated primary beam spectrum after passage through the attenuator. The beam spectra are derived by the depth dose effective method, i.e., by minimizing the difference between measured and calculated depth dose distributions, where the calculated distributions are derived by superposing data from a database for monoenergetic photons. The attenuator scatter is integrated over the area viewed from the calculation point of view using first scatter theory. Calculations are simplified by replacing the energy and angular-dependent cross-section formulas with the forward scatter constant r2(0) and a set of parametrized correction functions. The set of corrections include functions for the Compton energy loss, scatter attenuation, and secondary bremsstrahlung production. The effect of charged particle contamination is bypassed by avoiding use of dmax for absolute dose calibrations. The results of the model are compared with scatter measurements in air for copper and lead filters and with dose to a water phantom for lead filters for 4 and 18 MV. For attenuated beams, downstream of the buildup region, the calculated results agree with measurements on the 1.5% level. The accuracy was slightly less in situations

  4. Modeling transmission and scatter for photon beam attenuators.

    Science.gov (United States)

    Ahnesjö, A; Weber, L; Nilsson, P

    1995-11-01

    The development of treatment planning methods in radiation therapy requires dose calculation methods that are both accurate and general enough to provide a dose per unit monitor setting for a broad variety of fields and beam modifiers. The purpose of this work was to develop models for calculation of scatter and transmission for photon beam attenuators such as compensating filters, wedges, and block trays. The attenuation of the beam is calculated using a spectrum of the beam, and a correction factor based on attenuation measurements. Small angle coherent scatter and electron binding effects on scattering cross sections are considered by use of a correction factor. Quality changes in beam penetrability and energy fluence to dose conversion are modeled by use of the calculated primary beam spectrum after passage through the attenuator. The beam spectra are derived by the depth dose effective method, i.e., by minimizing the difference between measured and calculated depth dose distributions, where the calculated distributions are derived by superposing data from a database for monoenergetic photons. The attenuator scatter is integrated over the area viewed from the calculation point of view using first scatter theory. Calculations are simplified by replacing the energy and angular-dependent cross-section formulas with the forward scatter constant r2(0) and a set of parametrized correction functions. The set of corrections include functions for the Compton energy loss, scatter attenuation, and secondary bremsstrahlung production. The effect of charged particle contamination is bypassed by avoiding use of dmax for absolute dose calibrations. The results of the model are compared with scatter measurements in air for copper and lead filters and with dose to a water phantom for lead filters for 4 and 18 MV. For attenuated beams, downstream of the buildup region, the calculated results agree with measurements on the 1.5% level. The accuracy was slightly less in situations

  5. Radiation-attenuated vaccine for lungworm disease

    International Nuclear Information System (INIS)

    The work done at the Indian Veternary Research Institute, Izatnagar, on the development of a vaccine for lungworm diseases is reported. Research work done includes: (1) studies on the epidemiology and the incidence of the lungworm infections, (ii) studies on the radiation-attenuated lungworm Dictyocaulus filaria vaccine, (iii) studies on other parasites using ionizing radiation, (iv) incidence of lungworm infection in sheep in Jammu and Kashmir State, (v) suitable dose of gamma radiation for attenuation, (vi) laboratory studies with radiation-attenuated D. filaria vaccine, (vii) serology of D. filaria infection, (viii) field trials with the radiation-attenuated vaccine, (ix) immune response of previously exposed lambs to vaccination, (x) comparative susceptibility of sheep and goats to infection with D. filaria, (xi) quantitative studies of D. filaria in lambs and (xii) production and supply of lungworm vaccine. (A.K.)

  6. Simple Scheme for Variable High Power Laser Beam Attenuation

    OpenAIRE

    Bialkowski, Stephen E.

    1987-01-01

    A venetian style infrared attenuator placed prior to a pinhole spatial filter results in variable high‐power laser attenuation. This attenuation scheme has a wide dynamic range, results in high‐quality Gaussian beams, does not introduce beam walk‐off error, and is independent of polarization.

  7. Energy release, beam attenuation radiation damage, gas production and accumulation of long-lived activity in Pb, Pb-Bi and Hg targets

    Energy Technology Data Exchange (ETDEWEB)

    Shubin, Yu.N. [IPPE, Obninsk (Russian Federation)

    1996-06-01

    The calculation and analysis of the nuclei concentrations and long-lived residual radioactivity accumulated in Pb, Pb-Bi and Hg targets irradiated by 800 MeV, 30 mA proton beam have been performed. The dominating components to the total radioactivity of radionuclides resulting from fission and spallation reactions and radiative capture by both target nuclei and accumulated radioactive nuclei for various irradiation and cooling times were analyzed. The estimations of spectral component contributions of neutron and proton fluxes to the accumulated activity were carried out. The contributions of fission products to the targets activity and partial activities of main long-lived fission products to the targets activity and partial activities of main long-lived fission products were evaluated. The accumulation of Po isotopes due to reactions induced by secondary alpha-particles were found to be important for the Pb target as compared with two-step radiative capture. The production of Tritium in the targets and its contribution to the total targets activity was considered in detail. It is found that total activities of both targets are close to one another.

  8. Attenuation coefficient determination of printed ABS and PLA samples in diagnostic radiology standard beams

    Science.gov (United States)

    Veneziani, G. R.; Corrêa, E. L.; Potiens, M. P. A.; Campos, L. L.

    2016-07-01

    IAEA code of practice TRS-457 states that standard phantoms should offer the same primary attenuation and scatter production as relevant body section of a representative patient. Material cost, availability and dimensional stability must also be considered. The goal of this study is to determine the attenuation coefficient of printed ABS and PLA samples in standard X-ray beams, verifying if phantoms printed with these materials could be an easier-handle substitute for PMMA, enabling the creation of different designs in an easier and cheaper way. Results show that PMMA presents higher attenuation coefficient, followed by PLA and ABS, which means that thinner PMMA layer creates higher radiation attenuation.

  9. Attenuation coefficient determination of printed ABS and PLA samples in diagnostic radiology standard beams

    Energy Technology Data Exchange (ETDEWEB)

    Veneziani, G.R.; Correa, E.L.; Potiens, M.P.A.; Campos, L.L., E-mail: venezianigr@gmail.com [Instituto de Pesquisas Energeticas e Nucleres (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    IAEA code of practice TRS-457 states that standard phantoms should offer the same primary attenuation and scatter production as relevant body section of a representative patient. Material cost, availability and dimensional stability must also be considered. The goal of this study is to determine the attenuation coefficient of printed ABS and PLA in standard X-ray beams, verifying if phantoms printed with these materials could be an easier-handle substitute for PMMA, enabling the creation of different designs in an easier and cheaper way. Results show that PMMA presents higher attenuation coefficient, followed by PLA and ABS, which means that thinner PMMA layer creates higher radiation attenuation. (author)

  10. Beam diagnostics with synchrotron radiation

    International Nuclear Information System (INIS)

    Synchrotron radiation is often used to measure the dimensions of an electron beam. The transverse size is obtained from an image of the beam cross section formed by means of the emitted synchrotron radiation. Because of the small natural opening angle the resolution is limited by diffraction. The angular spread of the particles in the beam can be measured by observing the radiation directly. Here, the resolution is limited by the natural opening angle of the emitted light. Measuring both beam cross section and angular spread gives the emittance of the beam. However, in most cases only one of these two parameters is observed and the other deduced from the known particle beam optics at the source of the radiation. Usually one observes radiation emitted in long bending magnets. However, short magnets and undulators are also useful sources for these measurements. For practical reasons the beam diagnostics is carried out using visible or ultraviolet light. This part of the spectrum is usually far below the critical frequency, and corresponding approximations can be applied. Synchrotron radiation is an extremely useful tool for diagnostics in electron (or positron) rings. In some cases it has also served in proton rings using special magnets. (author)

  11. Attenuation of gamma radiation in concrete shields

    International Nuclear Information System (INIS)

    The attenuation characteristics of γ radiation in concrete layers considering their mechanical resistence and densities were determined. A 137Cs source was used in a 'good geometry' arrangement to eliminate the effects of the buildup factor. The ordinary and the heavy concrete were irradiated and for the latter it was used as additives iron ore and Fe2O3 pellets in various grain sizes. The detection system consisted of a 2' x 2' NaI (Tl) crystal coupled to a photomultiplier tube and the associated electronic equipment. FORTRAN programs were used for determining the absorption coefficients and the attenuation factors. These programs calculate photopeak areas eliminating all contributions due to Compton effect and background. (Author)

  12. Creating a collimated ultrasound beam in highly attenuating fluids.

    Science.gov (United States)

    Raeymaekers, Bart; Pantea, Cristian; Sinha, Dipen N

    2012-04-01

    We have devised a method, based on a parametric array concept, to create a low-frequency (300-500 kHz) collimated ultrasound beam in fluids highly attenuating to sound. This collimated beam serves as the basis for designing an ultrasound visualization system that can be used in the oil exploration industry for down-hole imaging in drilling fluids. We present the results of two different approaches to generating a collimated beam in three types of highly attenuating drilling mud. In the first approach, the drilling mud itself was used as a nonlinear mixing medium to create a parametric array. However, the short absorption length in mud limits the mixing length and, consequently, the resulting beam is weak and broad. In the second improved approach, the beam generation process was confined to a separate "frequency mixing tube" that contained an acoustically non-linear, low attenuation medium (e.g., water) that allowed establishing a usable parametric array in the mixing tube. A low-frequency collimated beam was thus created prior to its propagation into the drilling fluid. Using the latter technique, the penetration depth of the low frequency ultrasound beam in the drilling fluid was significantly extended. We also present measurements of acoustic nonlinearity in various types of drilling mud. PMID:22204917

  13. Metamaterial radiation from attenuated total reflection at terahertz frequencies

    Science.gov (United States)

    Ramani, Suchitra

    The focus of this research was to explore the behavior of two-dimensional planar metamaterials or metafilms and understand the various excitation schemes for application of metafilms to Terahertz-Attenuated Total Reflection spectroscopy (THz-ATR). A standard THz time domain spectroscopy system based on photoconductive switches was modified to implement the ATR technique. Finite metamaterial arrays with varying singly- split ring resonator sizes were excited in the Kretschmann ATR configuration using finite sized terahertz beams. Numerical approaches using commercial software were looked into to explain the experimental observations. Various theoretical models were used to explain the observed phenomena. The ATR measurements showed an unexpected strengthening of the resonance when the metafilm sample was illuminated near the edge. This phenomenon referred to in this study as "the anomalous edge enhancement" was observed strongly in metafilms with closely spaced rings. A re-radiation signal was observed across the total internal reflection barrier where no signal is expected. It consisted of two peaks one at the fundamental metamaterial resonance and the second peak was due to the periodicity of the metafilm array. The anomalous behavior seen in the ATR measurements is attributed to the edge currents at the boundary of the metafilm array giving rise to this re-radiation signal. Results from analytic treatments based on Floquet method and method of moments were able to qualitatively model the measurements. The observed re-radiation signal is a potential loss mechanism that could impact observations from commonly used transmission measurements on metamaterials.

  14. Heat radiative characteristics of ultra-attenuated materials

    Institute of Scientific and Technical Information of China (English)

    Dehong Xia; Yonghong Wu

    2004-01-01

    From the microstructure of heat radiation, the interaction between the incident heat radiative wave and the electromagnetism syntonic wave is analyzed to reveal the emission, absorption, transmission and reflection mechanisms of the incident heat radiative wave in materials. Based on Lorentz dispersion theory, the effect of optical parameters on heat radiative characteristics is also analyzed. The method of ultra-attenuation and nanocrystallization improving the heat radiative characteristics of the material and the emissivity dispersion of the ultra-attenuated materials are brought to light.

  15. Photon counting spectroscopic CT with dynamic beam attenuator

    CERN Document Server

    Atak, Haluk

    2016-01-01

    Purpose: Photon counting (PC) computed tomography (CT) can provide material selective CT imaging at lowest patient dose but it suffers from suboptimal count rate. A dynamic beam attenuator (DBA) can help with count rate by modulating x-ray beam intensity such that the low attenuating areas of the patient receive lower exposure, and detector behind these areas is not overexposed. However, DBA may harden the beam and cause artifacts and errors. This work investigates positive and negative effects of using DBA in PCCT. Methods: A simple PCCT with single energy bin, spectroscopic PCCT with 2 and 5 energy bins, and conventional energy integrating CT with and without DBA were simulated and investigated using 120kVp tube voltage and 14mGy air dose. The DBAs were modeled as made from soft tissue (ST) equivalent material, iron (Fe), and holmium (Ho) K-edge material. A cylindrical CT phantom and chest phantom with iodine and CaCO3 contrast elements were used. Image artifacts and quantification errors in general and mat...

  16. Imaging the attenuation coefficients of magnetically constrained positron beams in matter

    Science.gov (United States)

    Watson, Charles C.

    2016-09-01

    This paper describes a method for tomographically imaging the linear attenuation coefficients (LACs) of positron beams in heterogeneous materials. A β+ ray emitter such as 68Ga, placed in a uniform 3T static magnetic field, generates a well-defined positron beam that maintains its spatial coherence over an attenuation of more than 10-3 while signaling its intensity via the annihilation radiation it generates. A positron emission tomography (PET) system embedded in the magnetic field measures the positron-electron annihilation distribution within objects illuminated by the beam. It's shown that this image can be decomposed into maps of the positron beam's flux and its material-dependent LACs without need for auxiliary measurements or transmission of the beam completely through the object. The initial implementation employs a hybrid PET/magnetic resonance imaging (MRI) scanner developed for medical applications. Mass thicknesses up to 0.55 g/cm2 at a spatial resolution of a few millimeters have been imaged.

  17. Radiation dermatitis following electron beam therapy

    International Nuclear Information System (INIS)

    Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis. Although most patients had had acute radiation dermatitis, only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads

  18. Radiation dermatitis following electron beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Price, N.M.

    1978-01-01

    Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis. Although most patients had had acute radiation dermatitis, only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads.

  19. Phase Aberration and Attenuation Effects on Acoustic Radiation Force-Based Shear Wave Generation.

    Science.gov (United States)

    Carrascal, Carolina Amador; Aristizabal, Sara; Greenleaf, James F; Urban, Matthew W

    2016-02-01

    Elasticity is measured by shear wave elasticity imaging (SWEI) methods using acoustic radiation force to create the shear waves. Phase aberration and tissue attenuation can hamper the generation of shear waves for in vivo applications. In this study, the effects of phase aberration and attenuation in ultrasound focusing for creating shear waves were explored. This includes the effects of phase shifts and amplitude attenuation on shear wave characteristics such as shear wave amplitude, shear wave speed, shear wave center frequency, and bandwidth. Two samples of swine belly tissue were used to create phase aberration and attenuation experimentally. To explore the phase aberration and attenuation effects individually, tissue experiments were complemented with ultrasound beam simulations using fast object-oriented C++ ultrasound simulator (FOCUS) and shear wave simulations using finite-element-model (FEM) analysis. The ultrasound frequency used to generate shear waves was varied from 3.0 to 4.5 MHz. Results: The measured acoustic pressure and resulting shear wave amplitude decreased approximately 40%-90% with the introduction of the tissue samples. Acoustic intensity and shear wave displacement were correlated for both tissue samples, and the resulting Pearson's correlation coefficients were 0.99 and 0.97. Analysis of shear wave generation with tissue samples (phase aberration and attenuation case), measured phase screen, (only phase aberration case), and FOCUS/FEM model (only attenuation case) showed that tissue attenuation affected the shear wave generation more than tissue aberration. Decreasing the ultrasound frequency helped maintain a focused beam for creation of shear waves in the presence of both phase aberration and attenuation.

  20. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  1. Attenuation of X and Gamma Rays in Personal Radiation Shielding Protective Clothing.

    Science.gov (United States)

    Kozlovska, Michaela; Cerny, Radek; Otahal, Petr

    2015-11-01

    A collection of personal radiation shielding protective clothing, suitable for use in case of accidents in nuclear facilities or radiological emergency situations involving radioactive agents, was gathered and tested at the Nuclear Protection Department of the National Institute for Nuclear, Chemical and Biological Protection, Czech Republic. Attenuating qualities of shielding layers in individual protective clothing were tested via spectra measurement of x and gamma rays, penetrating them. The rays originated from different radionuclide point sources, the gamma ray energies of which cover a broad energy range. The spectra were measured by handheld spectrometers, both scintillation and High Purity Germanium. Different narrow beam geometries were adjusted using a special testing bench and a set of various collimators. The main experimentally determined quantity for individual samples of personal radiation shielding protective clothing was x and gamma rays attenuation for significant energies of the spectra. The attenuation was assessed comparing net peak areas (after background subtraction) in spectra, where a tested sample was placed between the source and the detector, and corresponding net peak areas in spectra, measured without the sample. Mass attenuation coefficients, which describe attenuating qualities of shielding layers materials in individual samples, together with corresponding lead equivalents, were determined as well. Experimentally assessed mass attenuation coefficients of the samples were compared to the referred ones for individual heavy metals. PMID:26425983

  2. Electron beam instrumentation techniques using coherent radiation

    International Nuclear Information System (INIS)

    Much progress has been made on coherent radiation research since coherent synchrotron radiation was first observed in 1989. The use of coherent radiation as a bunch length diagnostic tool has been studied by several groups. In this paper, brief introductions to coherent radiation and far-infrared measurement are given, the progress and status of their beam diagnostic application are reviewed, different techniques are described, and their advantages and limitations are discussed

  3. Light beam attenuation and backscattering properties of particles in the Bohai Sea and Yellow Sea with relation to biogeochemical properties

    Science.gov (United States)

    Wang, Shengqiang; Qiu, Zhongfeng; Sun, Deyong; Shen, Xiaojing; Zhang, Hailong

    2016-06-01

    This study reports the first results of the variability in light beam attenuation and the backscattering properties of particles and their controlling factors during the summer in the Bohai Sea (BS) and Yellow Sea (YS), which are two typical shallow and semienclosed seas. We observe large variations in the particulate beam attenuation (cp) and backscattering coefficients (bbp); such variations are mainly attributed to changes in the total suspended matter, while the cross-sectional area concentration shows tighter relationships with both cp and bbp. The mass-specific beam attenuation (cp*) and backscattering coefficients (bbp*) vary more widely over about two orders of magnitude. The attenuation (Qce) and backscattering efficiencies (Qbbe) are important factors that control cp* and bbp*, which clearly separate all the samples into two types. Type 1 samples show low Qce and Qbbe and contain relatively high proportions of organic or large particles, while type 2 samples have high Qce and Qbbe and mainly contain relatively small mineral particles. The majority of the variability in cp* and bbp* within each type is related to the inverse of the product of particle apparent density (ρa) and mean diameter (DA); ρa plays a major role, while DA exerts only a slight impact. Overall, this study provides general knowledge of particulate beam attenuation and the backscattering properties in the BS and YS, which may improve our understanding of underwater radiative transfer processes, marine biogeochemical processes and ocean color algorithms.

  4. Plume attenuation of laser radiation during high power fiber laser welding

    International Nuclear Information System (INIS)

    The results of an in-situ plume-laser interaction measurement during welding of mild steel with a 5 kW ytterbium fiber laser are reported. A measurement of the attenuation of probe laser beam passing through the plume has allowed to estimate the plume characteristics like the size of the extinction area and the spatial distribution of the extinction coefficient. The power loss of the fiber laser radiation propagating through the whole plume length was calculated. Together with a measured temporal characteristics of extinction the result indicates a significant decreasing of the laser radiation stability, which can lead to the formation of the macroscopic welding defects

  5. ALICE Transition Radiation Detector (TRD), test beam.

    CERN Multimedia

    2003-01-01

    Electrons and positrons can be discriminated from other charged particles using the emission of transition radiation - X-rays emitted when the particles cross many layers of thin materials. To develop such a Transition Radiation Detector(TRD) for ALICE many detector prototypes were tested in mixed beams of pions and electrons, as in the example shown here.

  6. Characteristics of liver tissue for attenuate the gamma radiation

    International Nuclear Information System (INIS)

    It was determined the lineal attenuation coefficient of hepatic tissue before gamma radiation of a source of 137 Cs. When exposing organic material before X or gamma radiation fields, part of the energy of the photons is absorbed by the material, while another part crosses it without producing any effect. The quantity of energy that is absorbed is a measure of the dose that receives the material. The three main mechanisms by means of which the gamma rays interacting with the matter are: The Photoelectric Effect, the Compton dispersion and the Even production; the sum of these three processes is translated in the attenuation coefficient of the radiation. In this work we have used hepatic tissue of bovine, as substitute of the human hepatic tissue, and we have measured the lineal attenuation coefficient for photons of 0.662 MeV. Through a series of calculations we have determined the lineal attenuation coefficient for photons from 10-3 to 10-5 MeV and the measured coefficient was compared with the one calculated. (Author)

  7. The Gas Flow from the Gas Attenuator to the Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Ryutov, D.D.

    2010-12-03

    The gas leak from the gas attenuator to the main beam line of the Linac Coherent Light Source has been evaluated, with the effect of the Knudsen molecular beam included. It has been found that the gas leak from the gas attenuator of the present design, with nitrogen as a working gas, does not exceed 10{sup -5} torr x l/s even at the highest pressure in the main attenuation cell (20 torr).

  8. Radiative trapping in intense laser beams

    Science.gov (United States)

    Kirk, J. G.

    2016-08-01

    The dynamics of electrons in counter-propagating, circularly polarized laser beams are shown to exhibit attractors whose ability to trap particles depends on the ratio of the beam intensities and a single parameter describing radiation reaction. Analytical expressions are found for the underlying limit cycles and the parameter range in which they are stable. In high-intensity optical pulses, where radiation reaction strongly modifies the trajectories, the production of collimated gamma-rays and the initiation of non-linear cascades of electron-positron pairs can be optimized by a suitable choice of the intensity ratio.

  9. Radiative trapping in intense laser beams

    CERN Document Server

    Kirk, J G

    2016-01-01

    The dynamics of electrons in counter-propagating, circularly polarized laser beams are shown to exhibit attractors whose ability to trap particles depends on the ratio of the beam intensities and a single parameter describing radiation reaction. Analytical expressions are found for the underlying limit cycles and the parameter range in which they are stable. In high-intensity optical pulses, where radiation reaction strongly modifies the trajectories, the production of collimated gamma-rays and the initiation of non-linear cascades of electron-positron pairs can be optimized by a suitable choice of the intensity ratio.

  10. Radiative trapping in intense laser beams

    Science.gov (United States)

    Kirk, J. G.

    2016-08-01

    The dynamics of electrons in counter-propagating, circularly polarized laser beams are shown to exhibit attractors whose ability to trap particles depends on the ratio of the beam intensities and a single parameter describing radiation reaction. Analytical expressions are found for the underlying limit cycles and the parameter range in which they are stable. In high-intensity optical pulses, where radiation reaction strongly modifies the trajectories, the production of collimated gamma-rays and the initiation of non-linear cascades of electron–positron pairs can be optimized by a suitable choice of the intensity ratio.

  11. Influence of magnetite and boron carbide on radiation attenuation of cement-fiber/composite

    International Nuclear Information System (INIS)

    Trial was made to create composites from agriculture fibers, which have good mechanical, physical and radiation attenuation properties for different applications. Fast neutron and gamma ray spectra, as well as, slow neutron fluxes behind samples of cement-fiber (CF) (ρ=2.095 g cm-3) and cement-fiber-magnetite (CFM) (ρ=2.858 g cm-3)/composites have been investigated. Neutron and gamma spectra have been measured using a collimated reactor beam and neutron- gamma spectrometer with stilbene scintillator. A pulse shape discrimination technique based on zero cross over method was used to discriminate between neutron and gamma ray pulses. While, slow neutron fluxes have been measured using a collimated reactor beam and BF3 counter. Results were used to achieve removal cross sections (ΣR,meas.), total attenuation coefficients (μ) and macroscopic cross sections (Σ) of fast neutrons, gamma rays and slow neutrons respectively from the attenuation relations. Also, removal cross sections (ΣR,cal.) and total mass attenuation coefficients (μ/ρ) of fast neutrons and gamma rays have been calculated using the composites elemental composition and XCOM code respectively. Measured and calculated results were compared and a reasonable agreement was found

  12. Interlaboratory comparison of radiation-induced attenuation in optical fibers

    Energy Technology Data Exchange (ETDEWEB)

    Friebele, E.J.; Lyons, P.B.; Blackburn, J.C.; Henschel, H.; Johan, A.; Krinsky, J.A.; Robinson, A.; Schneider, W.; Smith, D.; Taylor, E.W. (Naval Research Lab., Washington, DC (USA); Los Alamos National Lab., NM (USA); Harry Diamond Labs., Adelphi, MD (USA); Fraunhofer-Institut fuer Naturwissenschaftlich-Technische Trendanalysen (INT), Euskirchen (Germany, F.R.); Direction des Recherches, Etudes et Techni

    1989-08-01

    A comparison of the losses induced in step index multimode, graded index multimode and single mode fibers by pulsed radiation exposure has been made among 12 laboratories over a period of 5 years. The recoveries of the incremental attenuations from 10{sup -9} to 10{sup 1} s are reported. Although a standard set of measurement parameters was attempted, differences between the laboratories are evident; possible origins for these are discussed. 18 refs., 18 figs., 7 tabs.

  13. Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice.

    Directory of Open Access Journals (Sweden)

    Seung Jun Lee

    Full Text Available Radiation-induced lung injury (RILI is a common and unavoidable complication of thoracic radiotherapy. The current study was conducted to evaluate the ability of clarithromycin (CLA to prevent radiation-induced pneumonitis, oxidative stress, and lung fibrosis in an animal model. C57BL/6J mice were assigned to control, irradiation only, irradiation plus CLA, and CLA only groups. Test mice received single thoracic exposures to radiation and/or oral CLA (100 mg/kg/day. Histopathologic findings and markers of inflammation, fibrosis, and oxidative stress were compared by group. On a microscopic level, CLA inhibited macrophage influx, alveolar fibrosis, parenchymal collapse, consolidation, and epithelial cell changes. The concentration of collagen in lung tissue was lower in irradiation plus CLA mice. Radiation-induced expression of tumor necrosis factor (TNF-α, TNF receptor 1, acetylated nuclear factor kappa B, cyclooxygenase 2, vascular cell adhesion molecule 1, and matrix metallopeptidase 9 were also attenuated by CLA. Expression levels of nuclear factor erythroid 2-related factor 2 and heme oxygenase 1, transforming growth factor-β1, connective tissue growth factor, and type I collagen in radiation-treated lungs were also attenuated by CLA. These findings indicate that CLA ameliorates the deleterious effects of thoracic irradiation in mice by reducing pulmonary inflammation, oxidative damage, and fibrosis.

  14. Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice.

    Science.gov (United States)

    Lee, Seung Jun; Yi, Chin-ok; Heo, Rok Won; Song, Dae Hyun; Cho, Yu Ji; Jeong, Yi Yeong; Kang, Ki Mun; Roh, Gu Seob; Lee, Jong Deog

    2015-01-01

    Radiation-induced lung injury (RILI) is a common and unavoidable complication of thoracic radiotherapy. The current study was conducted to evaluate the ability of clarithromycin (CLA) to prevent radiation-induced pneumonitis, oxidative stress, and lung fibrosis in an animal model. C57BL/6J mice were assigned to control, irradiation only, irradiation plus CLA, and CLA only groups. Test mice received single thoracic exposures to radiation and/or oral CLA (100 mg/kg/day). Histopathologic findings and markers of inflammation, fibrosis, and oxidative stress were compared by group. On a microscopic level, CLA inhibited macrophage influx, alveolar fibrosis, parenchymal collapse, consolidation, and epithelial cell changes. The concentration of collagen in lung tissue was lower in irradiation plus CLA mice. Radiation-induced expression of tumor necrosis factor (TNF)-α, TNF receptor 1, acetylated nuclear factor kappa B, cyclooxygenase 2, vascular cell adhesion molecule 1, and matrix metallopeptidase 9 were also attenuated by CLA. Expression levels of nuclear factor erythroid 2-related factor 2 and heme oxygenase 1, transforming growth factor-β1, connective tissue growth factor, and type I collagen in radiation-treated lungs were also attenuated by CLA. These findings indicate that CLA ameliorates the deleterious effects of thoracic irradiation in mice by reducing pulmonary inflammation, oxidative damage, and fibrosis. PMID:26114656

  15. Laser synchrotron radiation and beam cooling

    Energy Technology Data Exchange (ETDEWEB)

    Esarey, E.; Sprangle, P.; Ting, A. [Naval Research Lab., Washington, DC (United States)] [and others

    1995-12-31

    The interaction of intense {approx_gt} 10{sup 18} W/cm{sup 2}, short pulse ({approx_lt} 1 ps) lasers with electron beams and plasmas can lead to the generation of harmonic radiation by several mechanisms. Laser synchrotron radiation may provide a practical method for generating tunable, near monochromatic, well collimated, short pulse x-rays in compact, relatively inexpensive source. The mechanism for the generation of laser synchrotron radiation is nonlinear Thomson scattering. Short wavelengths can be generated via Thomson scattering by two methods, (i) backscattering from relativistic electron beams, in which the radiation frequency is upshifted by the relativistic factor 4{gamma}{sup 2}, and (ii) harmonic scattering, in which a multitude of harmonics are generated with harmonic numbers extending out to the critical harmonic number nc{approx_equal}a{sub 0}{sup 3} {much_gt} 1, where a{sub 0} {approx_equal}10{sup -9}{lambda}I{sup 1/2}, {lambda} is the laser wavelength in {mu}m and I is the laser intensity in W/cm{sup 2}. Laser synchrotron sources are capable of generating short ({approx_lt} ps) x-ray pulses with high peak flux ({approx_gt} 10{sup 21} photons/s) and brightness ({approx_gt}{sup 19} photons/s-mm{sup 2}-mrad{sup 2} 0.1%BW. As the electron beam radiates via Thomson scattering, it can subsequently be cooled, i.e., the beam emittance and energy spread can be reduced. This cooling can occur on rapid ({approximately} ps) time scales. In addition, electron distributions with sufficiently small axial energy spreads can be used to generate coherent XUV radiation via a laser-pumped FEL mechanism.

  16. Principle of Terahertz Radiation Using Electron Beams

    Science.gov (United States)

    Shin, Young-Min; Choi, Eun-Mi; Park, Gun-Sik

    This part introduces high power THz coherent radiation sources that take advantage of free electron beams. Following a description of characteristics on vacuum electron devices (VEDs), fundamental radiation principle of beam-wave interaction is explained with specifying their types and applications. Conventional high power microwave VEDs such as klystrons, TWTs, gyrotrons, and FELs are described in their technical perspectives with brief overview of device characteristics. Addressing technical challenges on up-conversion-to-THz of conventional approach, this part explores the state-of-the-art micro-VEDs considered for modern THz applications such as communication, imaging, sensing, spectroscopy, and so on, which are combined with modern microfabrication technologies. Novel MEMS techniques to microminiaturize RF components such as electron gun and RF interaction circuits are also presented.

  17. Radiation damping in pulsed Gaussian beams

    CERN Document Server

    Harvey, Chris

    2011-01-01

    We consider the effects of radiation damping on the electron dynamics in a Gaussian beam model of a laser field. For high intensities, i.e. with dimensionless intensity a0 \\gg 1, it is found that the dynamics divide into three regimes. For low energy electrons (low initial {\\gamma}-factor, {\\gamma}0) the radiation damping effects are negligible. At higher energies, but still at 2{\\gamma}0 a0 one is in a regime of radiation reaction induced electron capture. This capture is found to be stable with respect to the spatial properties of the electron beam and results in a significant energy loss of the electrons. In this regime the plane wave model of the laser field provides a good description of the dynamics, whereas for lower energies the Gaussian beam and plane wave models differ significantly. Finally the dynamics are considered for the case of an XFEL field. It is found that the significantly lower intensities of such fields inhibits the damping effects.

  18. Ocean Lidar Measurements of Beam Attenuation and a Roadmap to Accurate Phytoplankton Biomass Estimates

    Science.gov (United States)

    Hu, Yongxiang; Behrenfeld, Mike; Hostetler, Chris; Pelon, Jacques; Trepte, Charles; Hair, John; Slade, Wayne; Cetinic, Ivona; Vaughan, Mark; Lu, Xiaomei; Zhai, Pengwang; Weimer, Carl; Winker, David; Verhappen, Carolus C.; Butler, Carolyn; Liu, Zhaoyan; Hunt, Bill; Omar, Ali; Rodier, Sharon; Lifermann, Anne; Josset, Damien; Hou, Weilin; MacDonnell, David; Rhew, Ray

    2016-06-01

    Beam attenuation coefficient, c, provides an important optical index of plankton standing stocks, such as phytoplankton biomass and total particulate carbon concentration. Unfortunately, c has proven difficult to quantify through remote sensing. Here, we introduce an innovative approach for estimating c using lidar depolarization measurements and diffuse attenuation coefficients from ocean color products or lidar measurements of Brillouin scattering. The new approach is based on a theoretical formula established from Monte Carlo simulations that links the depolarization ratio of sea water to the ratio of diffuse attenuation Kd and beam attenuation C (i.e., a multiple scattering factor). On July 17, 2014, the CALIPSO satellite was tilted 30° off-nadir for one nighttime orbit in order to minimize ocean surface backscatter and demonstrate the lidar ocean subsurface measurement concept from space. Depolarization ratios of ocean subsurface backscatter are measured accurately. Beam attenuation coefficients computed from the depolarization ratio measurements compare well with empirical estimates from ocean color measurements. We further verify the beam attenuation coefficient retrievals using aircraft-based high spectral resolution lidar (HSRL) data that are collocated with in-water optical measurements.

  19. Radiative transfer simulations of magnetar flare beaming

    Science.gov (United States)

    van Putten, T.; Watts, A. L.; Baring, M. G.; Wijers, R. A. M. J.

    2016-09-01

    Magnetar giant flares show oscillatory modulations in the tails of their light curves, which can only be explained via some form of beaming. The fireball model for magnetar bursts has been used successfully to fit the phase-averaged light curves of the tails of giant flares, but so far no attempts have been made to fit the pulsations. We present a relatively simple numerical model to simulate beaming of magnetar flare emission. In our simulations, radiation escapes from the base of a fireball trapped in a dipolar magnetic field, and is scattered through the optically thick magnetosphere of the magnetar until it escapes. Beaming is provided by the presence of a relativistic outflow, as well as by the geometry of the system. We find that a simple picture for the relativistic outflow is enough to create the pulse fraction and sharp peaks observed in pulse profiles of magnetar flares, while without a relativistic outflow the beaming is insufficient to explain giant flare rotational modulations.

  20. Radiative transfer simulations of magnetar flare beaming

    CERN Document Server

    van Putten, T; Baring, M G; Wijers, R A M J

    2016-01-01

    Magnetar giant flares show oscillatory modulations in the tails of their light curves, which can only be explained via some form of beaming. The fireball model for magnetar bursts has been used successfully to fit the phase-averaged light curves of the tails of giant flares, but so far no attempts have been made to fit the pulsations. We present a relatively simple numerical model to simulate beaming of magnetar flare emission. In our simulations, radiation escapes from the base of a fireball trapped in a dipolar magnetic field, and is scattered through the optically thick magnetosphere of the magnetar until it escapes. Beaming is provided by the presence of a relativistic outflow, as well as by the geometry of the system. We find that a simple picture for the relativistic outflow is enough to create the pulse fraction and sharp peaks observed in pulse profiles of magnetar flares, while without a relativistic outflow the beaming is insufficient to explain giant flare rotational modulations.

  1. Attenuation coefficient of usable solar radiation of the global oceans

    Science.gov (United States)

    Lin, Junfang; Lee, Zhongping; Ondrusek, Michael; Kahru, Mati

    2016-05-01

    Usable solar radiation (USR) represents spectrally integrated solar energy in the spectral range of 400-560 nm, a domain where photons penetrate the most in oceanic waters and thus contribute to photosynthesis and heating at deeper depths. Through purely numerical simulations, it was found that the diffuse attenuation coefficient of downwelling USR (Kd(USR), m-1) is nearly a constant vertically in the upper water column for clear waters and most turbid waters. Subsequently an empirical model was developed to estimate Kd(USR) based on the diffuse attenuation coefficient at 490 nm (Kd(490), m-1). We here evaluate this relationship using data collected from a wide range of oceanic and coastal environments and found that the relationship between Kd(490) and Kd(USR) developed via the numerical simulation is quite robust. We further refined this relationship to extend the applicability to "clearest" natural waters. This refined relationship was then used to produce sample distribution of Kd(USR) of global oceans. As expected, extremely low Kd(USR) (˜0.02 m-1) was observed in ocean gyres, while significantly higher Kd(USR) (˜5.2 m-1) was found in very turbid coastal regions. A useful application of Kd(USR) is to easily and accurately propagate surface USR to deeper depths, potentially to significantly improve the estimation of basin scale primary production and heat fluxes in the upper water column.

  2. Enhancement of heat radiative characteristics of coatings by ultra-attenuation

    Institute of Scientific and Technical Information of China (English)

    Dehong Xia; Yonghong Wu

    2004-01-01

    The absorption process of radiative heat in its transmission medium and the effect of ultra-attenuation on the radiative characteristics are analyzed in detail. A method of ultra-attenuation to enhance the radiative characteristics of the medium is proposed. It is proved that decreasing the particle size of coatings can increase the transmission depth of radiative heat and get higher emissivity and absorptivity both theoretically and practically. Ultra-attenuation and nanocrystallization will bring a brilliant prospect to the development of radiative coatings.

  3. Coherent Radiation from Relativistic Electron Beams.

    Science.gov (United States)

    Chen, Kuan-Ren

    Two new laser concepts, the Ion-Ripple Laser (IRL) and the Ion-Channel Laser (ICL), are proposed. A unified theory for coherent radiation from relativistic electron beams devices is developed; the theory not only links the physics of Cyclotron Masers (CMs) and Free Electron Lasers (FELs) but covers the physics of the IRLs and the ICLs. We have also invented a new numerical method, the Neo-Finite -Difference (NFD) method, for electromagnetic plasma simulations and applied it to studies of these lasers. The unified amplification theory compares the growth mechanisms. Two bunching mechanisms (both axial and azimuthal) exist, not only for the noncollective single electron resonance regime, but also in the collective gain regime. Competition or reinforcement between the two bunching mechanisms is determined by the q value (a parameter that determines how the electron oscillation frequency depends on energy), the electron axial velocity, and the wave phase velocity. The unified theory concludes that, for wave amplification, the sign of the electron mismatch frequency is required to be the same as the sign of a bunching parameter that is determined by the total bunching. In an IRL, a relativistic electron beam propagates obliquely through an ion ripple in a plasma. The radiation frequency depends on the beam energy, the ripple wave number, and the angle: omega ~ 2gamma ^{2}k_{ir}ccos theta. By proper choice of device parameters, sources of microwaves, optical, and perhaps even X-rays can be made. The dispersion relation for wave coupling is derived and used to calculate the radiation frequency and linear growth rate. The nonlinear saturation mechanism is explored. Computer simulation is used to verify the ideas, scaling laws and nonlinear mechanisms. In an ICL, the ion focusing force causes the electrons to oscillate about the channel axis and plays a similar role to the magnetic field in a CM. This electron motion is nonlinear and is studied. Simulations were performed

  4. External beam radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. -- The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. -- Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. -- The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachytherapy. The current status of radical prostatectomy and cryotherapy will be summarized. Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. -- Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. -- The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

  5. The VANILLA sensor as a beam monitoring device for X-ray radiation therapy.

    Science.gov (United States)

    Velthuis, J J; Hugtenburg, R P; Cussans, D; Perry, M; Hall, C; Stevens, P; Lawrence, H; McKenzie, A

    2014-01-01

    Cancer treatments such as intensity-modulated radiotherapy (IMRT) require increasingly complex methods to verify the accuracy and precision of the treatment delivery. In vivo dosimetry based on measurements made in an electronic portal imaging device (EPID) has been demonstrated. The distorting effect of the patient anatomy on the beam intensity means it is difficult to separate changes in patient anatomy from changes in the beam intensity profile. Alternatively, upstream detectors scatter and attenuate the beam, changing the energy spectrum of the beam, and generate contaminant radiation such as electrons. We used the VANILLA device, a Monolithic Active Pixel Sensor (MAPS), to measure the 2D beam profile of a 6 MV X-ray beam at Bristol Hospital in real-time in an upstream position to the patient without clinically significant disturbance of the beam (0.1% attenuation). MAPSs can be made very thin (~20 μm) with still a very good signal-to-noise performance. The VANILLA can reconstruct the collimated beam edge with approximately 64 μm precision.

  6. Influence of magnetite, ilmenite and boron carbide on radiation attenuation of polyester composites

    International Nuclear Information System (INIS)

    This work is concerned with studying polyester/ magnetite CUP/Mag (ρ=2.75 g cm−3) and polyester/ ilmenite CUP/Ilm (ρ=2.7 g cm−3) composites for shielding of medical facilities, laboratory hot cells and for various purposes. Mechanical and physical properties such as compressive, flexural and impact strengths, as well as, a.c. electrical conductivity, specific heat, water absorption and porosity have been performed to evaluate the composite capabilities for radiation shielding. A collimated beam from fission 252Cf (100 µg) neutron source and neutron-gamma spectrometer with stilbene scintillator based on the zero cross over method and pulse shape discrimination (P.S.D.) technique have been used to measure neutron and gamma ray spectra. Fluxes of thermal neutrons have been measured using the BF3 detector and thermal neutron detection system. The attenuation parameters, namely macroscopic effective removal cross-section ΣR, total attenuation coefficient µ and macroscopic cross-section Σ of fast neutrons, gamma rays and thermal neutrons respectively have been evaluated. Theoretical calculations using MCNP–4C2 code was used to calculate ΣR,μ and Σ. Also, MERCSF-N program was used to calculate macroscopic effective removal cross-section ΣR. Measured and calculated results were compared and reasonable agreement was found. - Highlights: • Loaded polyester composites were investigated for radiation shielding. • Some mechanical and physical properties were examined. • Experimental and theoretical attenuation parameters were studied. • Experimental and theoretical (MCNP-4C2) results were in good agreement

  7. Radiation shielding of the beam absorber in the MI 8-GeV beam line

    Energy Technology Data Exchange (ETDEWEB)

    Rakhno, I.; /Fermilab

    2006-01-01

    Results of Monte Carlo radiation shielding calculations performed for the beam absorber of the MI 8 GeV beam line are presented and discussed. The possibility to reach the level of 10{sup 19} protons per year is investigated.

  8. Estuarine morphometry governs optically active substances, Kd(PAR) and beam attenuation

    DEFF Research Database (Denmark)

    Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.;

    2013-01-01

    this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two......Data on optical properties such as diffuse attenuation coefficient Kd(PAR), beam attenuation coefficient (cp) and the optically active constituents (OACs) CDOM, Chl-a and suspended particulate matter were obtained in a Danish temperate coastal plain estuary (56°N) and a Vietnamese tropical ria (12...

  9. Transverse beam shape measurements of intense proton beams using optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Scarpine, Victor E.; /Fermilab

    2012-03-01

    A number of particle physics experiments are being proposed as part of the Department of Energy HEP Intensity Frontier. Many of these experiments will utilize megawatt level proton beams onto targets to form secondary beams of muons, kaons and neutrinos. These experiments require transverse size measurements of the incident proton beam onto target for each beam spill. Because of the high power levels, most beam intercepting profiling techniques will not work at full beam intensity. The possibility of utilizing optical transition radiation (OTR) for high intensity proton beam profiling is discussed. In addition, previous measurements of OTR beam profiles from the NuMI beamline are presented.

  10. Attenuation coefficient of 123 keV gamma radiation by dilute solution of ferrous sulphate

    International Nuclear Information System (INIS)

    Linear and mass attenuation coefficients of 123 keV gamma radiation from Co57 by dilute solutions of FeSO4.7H2O salt are studied for varying concentrations. The mixture rule for theoretical calculation of attenuation coefficients is developed for solutions. The study explores the validity of the expected exponential attenuation absorption law for gamma radiation in solutions and also provides alternative method for direct determination of linear and mass attenuation coefficients of soluble salts in solid form without obtaining them in pure crystalline form. (author). 12 refs., 1 tab., 1 fig

  11. Calculation of narrow beam γ ray mass attenuation coefficients of absorbing medium by Monte Carlo method

    International Nuclear Information System (INIS)

    The mathematics model of particle transportation was built, based on the sample of the impaction trace of the narrow beam γ photon in the medium according to the principle of interaction between γ photon and the material, and a computer procedure was organized to simulate the process of transportation for the γ photon in the medium and record the emission probability of γ photon and its corresponding thickness of medium with LabWindows/CVI, which was used to calculate narrow beam γ ray mass attenuation coefficients of absorbing medium. The results show that it is feasible for Monte Carlo method to calculate narrow beam γ ray mass attenuation coefficients of absorbing medium. (authors)

  12. Determination of the Absorption Coefficient and Cloudiness Multiplicity Attenuation During the Gamma-Radiation Passage

    Science.gov (United States)

    Orlova, K. N.; Borovikov, I. F.; Gaidamak, M. A.

    2016-08-01

    The paper presents background value equivalent dose of gamma-radiation investigation in different weather: clear cloudy and overcast. The change of the dose rate of gamma radiation, depending on the weather and the ability cloudiness to shield gamma rays is shown. A new method for eliminating the consequences of accidents at nuclear power plants or plants using radioactive elements is proposed. A calculation method of cloudiness coefficient absorption and cloudiness gamma-radiation multiplicity attenuation is developed. The gamma- radiation multiplicity attenuation and the absorption coefficient of gamma radiation were calculated.

  13. Shielding data for hadron-therapy ion accelerators: Attenuation of secondary radiation in concrete

    CERN Document Server

    Agosteo, S; Sagia, E; Silari, M

    2014-01-01

    The secondary radiation field produced by seven different ion species (from hydrogen to nitrogen), impinging onto thick targets made of either iron or ICRU tissue, was simulated with the FLUKA Monte Carlo code, and transported through thick concrete shields: the ambient dose equivalent was estimated and shielding parameters evaluated. The energy for each ion beam was set in order to reach a maximum penetration in ICRU tissue of 290 mm (equivalent to the therapeutic range of 430 MeV/amu carbon ions). Source terms and attenuation lengths are given as a function of emission angle and ion species, along with fits to the Monte Carlo data, for shallow depth and deep penetration in the shield. Trends of source terms and attenuation lengths as a function of neutron emission angle and ion species impinging on tar- get are discussed. A comparison of double differential distributions of neutrons with results from similar simulation works reported in the literature is also included. The aim of this work is to provide shi...

  14. Cellular effects after exposure to mixed beams of ionizing radiation

    OpenAIRE

    Staaf, Elina

    2012-01-01

    Mixed beams of ionizing radiation in our environment originate from space, the bedrock and our own houses. Radiotherapy patients treated with boron neutron capture therapy or with high energy photons are also exposed to mixed beams of gamma radiation and neutrons. Earlier investigations have reported additivity as well as synergism (a greater than additive response) when combining radiations of different linear energy transfer. However, the outcome seemed to be dependent on the experimental s...

  15. Determination of mass attenuation coefficients of gamma radiation for different fuel compositions

    International Nuclear Information System (INIS)

    In the work experimental methods for determination of gamma-radiation mass attenuation coefficients by the way of attenuation curves reading is given. The gamma-spectrometric method is used for 235U content in different fuel compositions (uranium dioxide (UO2), uranium intermetallic (U(AlSi)3), uranium mononitride (UN), double uranium carbide (UC+ZrC+C). Attenuation curves for gamma-quanta with Eγ=185 keV is given

  16. Rosiglitazone attenuates pulmonary fibrosis and radiation-induced intestinal damage

    International Nuclear Information System (INIS)

    Full text of publication follows: Purpose.-The aim of the study was to evaluate radioprotective effect of rosiglitazone (RGZ) on a murine model of late pulmonary damage and of acute intestinal damage. Methods.- Lung fibrosis: C57 mice were treated with the radiomimetic agent bleomycin, with or without rosiglitazone (5 mg/kg/day). To obtain an independent qualitative and quantitative measure for lung fibrosis we used high resolution CT, performed twice a week during the entire observation period. Hounsfield Units (HU) of section slides from the upper and lower lung region were determined. On day 31 lungs were collected for histological analysis. Acute intestinal damage: mice underwent 12 Gy total body irradiation with or without rosiglitazone. Mice were sacrificed 24 or 72 h after total body irradiation and ileum and colon were collected. Results.- Lung fibrosis: after bleomycin treatment, mice showed typical CT features of lung fibrosis, including irregular septal thickening and patchy peripheral reticular abnormalities. Accordingly, HU lung density was dramatically increased. Rosiglitazone markedly attenuated the radiological signs of fibrosis and strongly inhibited HU lung density increase (60% inhibition at the end of the observation period). Histological analysis revealed that in bleomycin-treated mice, fibrosis involved 50-55% of pulmonary parenchyma and caused an alteration of the alveolar structures in 10% of parenchyma, while in rosiglitazone-treated mice, fibrosis involved only 20-25% of pulmonary parenchyma, without alterations of the alveolar structures. Acute intestinal damage: 24 h after 12 Gy of total body irradiation intestinal mucosa showed villi shortening, mucosal thickness and crypt necrotic changes. Rosiglitazone showed a histological improvement of tissue structure, with villi and crypts normalization and oedema reduction. Conclusion.- These results demonstrate that rosiglitazone displays a protective effect on pulmonary fibrosis and radiation

  17. Rosiglitazone attenuates pulmonary fibrosis and radiation-induced intestinal damage

    Energy Technology Data Exchange (ETDEWEB)

    Mangoni, M.; Gerini, C.; Sottili, M.; Cassani, S.; Stefania, G.; Biti, G. [Radiotherapy Unit, Clinical Physiopathology Department, University of Florence, Firenze (Italy); Castiglione, F. [Department of Human Pathology and Oncology, University of Florence, Firenze (Italy); Vanzi, E.; Bottoncetti, A.; Pupi, A. [Nuclear Medicine Unit, Clinical Physiopathology Department, University of Florence, Firenze (Italy)

    2011-10-15

    Full text of publication follows: Purpose.-The aim of the study was to evaluate radioprotective effect of rosiglitazone (RGZ) on a murine model of late pulmonary damage and of acute intestinal damage. Methods.- Lung fibrosis: C57 mice were treated with the radiomimetic agent bleomycin, with or without rosiglitazone (5 mg/kg/day). To obtain an independent qualitative and quantitative measure for lung fibrosis we used high resolution CT, performed twice a week during the entire observation period. Hounsfield Units (HU) of section slides from the upper and lower lung region were determined. On day 31 lungs were collected for histological analysis. Acute intestinal damage: mice underwent 12 Gy total body irradiation with or without rosiglitazone. Mice were sacrificed 24 or 72 h after total body irradiation and ileum and colon were collected. Results.- Lung fibrosis: after bleomycin treatment, mice showed typical CT features of lung fibrosis, including irregular septal thickening and patchy peripheral reticular abnormalities. Accordingly, HU lung density was dramatically increased. Rosiglitazone markedly attenuated the radiological signs of fibrosis and strongly inhibited HU lung density increase (60% inhibition at the end of the observation period). Histological analysis revealed that in bleomycin-treated mice, fibrosis involved 50-55% of pulmonary parenchyma and caused an alteration of the alveolar structures in 10% of parenchyma, while in rosiglitazone-treated mice, fibrosis involved only 20-25% of pulmonary parenchyma, without alterations of the alveolar structures. Acute intestinal damage: 24 h after 12 Gy of total body irradiation intestinal mucosa showed villi shortening, mucosal thickness and crypt necrotic changes. Rosiglitazone showed a histological improvement of tissue structure, with villi and crypts normalization and oedema reduction. Conclusion.- These results demonstrate that rosiglitazone displays a protective effect on pulmonary fibrosis and radiation

  18. Two Effective Heuristics for Beam Angle Optimization in Radiation Therapy

    CERN Document Server

    Yarmand, Hamed

    2013-01-01

    In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem can be modeled using mixed integer programming (MIP) whose solution gives the optimal beam orientation as well as optimal beam intensity. The challenge, however, is the computation time for this large scale MIP. We propose and investigate two novel heuristic approaches to reduce the computation time considerably while attaining high-quality solutions. We introduce a family of heuristic cuts based on the concept of 'adjacent beams' and a beam elimination scheme based on the contribution of each beam to deliver the dose to the tumor in the ideal plan in which all potential beams can be used simultaneously. We show the effectiveness of these heuristics for intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) on a clinical liver case.

  19. Critical analysis of soil hydraulic conductivity determination using monoenergetic gamma radiation attenuation

    International Nuclear Information System (INIS)

    Three soil samples of different textures: LVA (red yellow latosol), LVE (dark red latosol) and LRd (dystrophic dark red latosol) were utilized for unsaturated hydraulic conductivity K(θ) measurements. Soil bulk densities and water contents during internal water drainage were measured by monoenergetic gamma radiation attenuation, using homogeneous soil columns assembled in the laboratory. The measurements were made with a collimated gamma beam of 0.003 m in diameter using a Nal(Tl) (3'' x 3 '') detector and a 137Cs gamma source of 74 X 108 Bq and 661.6 KeV. Soil columns were scanned with the gamma beam from 0.01 to 0.20 m depth, in 0.01m steps, for several soil water redistribution times. The results show a great variability of the unsaturated hydraulic conductivity relation K(θ), even though homogeneous soils were used. The variability among methods is significantly smaller in relation to variability in space. The assumption of unit hydraulic gradient during redistribution of soil water utilized in the methods of Hillel, Libardi and Sisson leads to hydraulic conductivity values that increase in depth. The exponential character of the K(θ) relationship, is responsible for the difficulty of estimating soil hydraulic conductivity, which is a consequence of small variations in the porous arrangement, even in samples supposed to be homogeneous. (author)

  20. Attenuation of 10 MeV electron beam energy to achieve low doses does not affect Salmonella spp. inactivation kinetics

    Science.gov (United States)

    Hieke, Anne-Sophie Charlotte; Pillai, Suresh D.

    2015-05-01

    The effect of attenuating the energy of a 10 MeV electron beam on Salmonella inactivation kinetics was investigated. No statistically significant differences were observed between the D10 values of either Salmonella 4,[5],12:i:- or a Salmonella cocktail (S. 4,[5],12:i:-, Salmonella Heidelberg, Salmonella Newport, Salmonella Typhimurium, Salmonella) when irradiated with either a non-attenuated 10 MeV eBeam or an attenuated 10 MeV eBeam (~2.9±0.22 MeV). The results show that attenuating the energy of a 10 MeV eBeam to achieve low doses does not affect the inactivation kinetics of Salmonella spp. when compared to direct 10 MeV eBeam irradiation.

  1. Power Beaming Leakage Radiation as a SETI Observable

    CERN Document Server

    Benford, James N

    2016-01-01

    The most observable leakage radiation from an advanced civilization may well be from the use of power beaming to transfer energy and accelerate spacecraft. Applications suggested for power beaming involve Earth-to-space applications such as launching spacecraft to orbit, raising satellites to a higher orbit, and interplanetary concepts involving space-to-space transfers of cargo or passengers. We also quantify beam-driven launch to the outer solar system, interstellar precursors and ultimately starships. We estimate the principal observable parameters of power beaming leakage. Extraterrestrial civilizations would know their power beams could be observed, and so could put a message on the power beam and broadcast it for our receipt at little additional energy or cost. By observing leakage from power beams we may find a message embedded on the beam. Recent observations of the anomalous star KIC 8462852 by the Allen Telescope Array (ATA) set some limits on extraterrestrial power beaming in that system. We show t...

  2. Attenuation of gamma-radiation by multilayer polymer disperse-filled structures

    International Nuclear Information System (INIS)

    The results of attenuation of gamma-radiation in multilayered structures containing polymer matrix and super-dispersed powders are presented. These structures, which represented as combination of layers with gradient of effective atomic number, reveal anisotropy of attenuation of low-energy gamma-radiation in normal direction relative to plane of layers. Application of structures in engineering materials of containers for radioactive waste or spent fuel provide reduction of their weight comparatively of containers made from steel and concrete.

  3. The radiation measurement applied to beam lifetime study on the synchrotron radiation facilities

    Science.gov (United States)

    Li, Yuxiong; Li, Juexin; Liu, Zuping; Cui, Yonggang; Gong, Guanghua; Shao, Beibei

    2003-06-01

    To collect beam loss information from an accelerator radiation field is helpful to machine study and operation. For a synchrotron radiation storage ring, shower electrons give a distinct clue to loss location and a BLM-XS model detector is suitable to detect them. Recently, we set up a new beam loss monitoring system by this method for National Synchrotron Radiation Laboratory (NSRL) storage ring. It does not interfere with the vacuum chamber and machine operation. Different from other systems, the detectors are used in pairs, fixed on opposite sides of the chamber separately. Some interesting phenomena about beam lifetime were observed. We located exactly where an excessive beam loss took place during ramping process and solved the problem. It was proved that gas accumulated at the front ends of photo-beam lines strongly impacted the electron beam and led to beam lifetime decreases. The cause of beam lifetime decrease because of superconducting wiggler is discussed.

  4. Particle beam radiation therapy:re-introducing the future

    Institute of Scientific and Technical Information of China (English)

    Omar Abdel-Rahman

    2014-01-01

    Particle radiation therapy is an exciting area of radiotherapy basic and clinical researches. The majority of particle radiotherapy work is being done with proton beams having essential y the same radiobiologic properties as conventional photon/electron radiation but al owing a much more precise control of the radiation dose distribution. However, other charged particles are also playing an increasing role, like neutrons. In this review article we wil summarize the data related to basic and clinical experiences related to particle beam radiation therapy.

  5. Synchrotron radiation based beam diagnostics at the Fermilab Tevatron

    CERN Document Server

    Thurman-Keup, R; Hahn, A; Hurh, P; Lorman, E; Lundberg, C; Meyer, T; Miller, D; Pordes, S; Valishev, A

    2011-01-01

    Synchrotron radiation has been used for many years as a beam diagnostic at electron accelerators. It is not normally associated with proton accelerators as the intensity of the radiation is too weak to make detection practical. However, if one utilizes the radiation originating near the edge of a bending magnet, or from a short magnet, the rapidly changing magnetic field serves to enhance the wavelengths shorter than the cutoff wavelength, which for more recent high energy proton accelerators such as Fermilab's Tevatron, tends to be visible light. This paper discusses the implementation at the Tevatron of two devices. A transverse beam profile monitor images the synchrotron radiation coming from the proton and antiproton beams separately and provides profile data for each bunch. A second monitor measures the low-level intensity of beam in the abort gaps which poses a danger to both the accelerator's superconducting magnets and the silicon detectors of the high energy physics experiments. Comparisons of measur...

  6. Beaming of particles and synchrotron radiation in relativistic magnetic reconnection

    CERN Document Server

    Kagan, Daniel; Piran, Tsvi

    2016-01-01

    Relativistic reconnection has been invoked as a mechanism for particle acceleration in numerous astrophysical systems. According to idealised analytical models reconnection produces a bulk relativistic outflow emerging from the reconnection sites (X-points). The resulting radiation is therefore highly beamed. Using two-dimensional particle-in-cell (PIC) simulations, we investigate particle and radiation beaming, finding a very different picture. Instead of having a relativistic average bulk motion with isotropic electron velocity distribution in its rest frame, we find that the bulk motion of particles in X-points is similar to their Lorentz factor gamma, and the particles are beamed within about 5/gamma. On the way from the X-point to the magnetic islands, particles turn in the magnetic field, forming a fan confined to the current sheet. Once they reach the islands they isotropise after completing a full Larmor gyration and their radiation is not strongly beamed anymore. The radiation pattern at a given freq...

  7. Fibre-Coupling Zig-Zag Beam Deflection Technology for Investigation of Attenuation Process of Laser-Induced Shock Waves

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ping; BIAN Bao-Min; LI Zhen-Hua

    2005-01-01

    @@ A novel fibre-coupling zig-zag beam deflection technology is developed to investigate the attenuation process of laser-induced shock waves in air. Utilizing ordinal reflections of probe beams by a pair of parallel mirrors,a zig-zag beam field is formed, which has eleven probe beams in the horizontal plane. When a laser-induced shock wave propagates through the testing field, it causes eleven deflection signals one after another. The whole attenuation process of the shock wave in air can be detected and illuminated clearly on one experimental curve.

  8. Aerosols attenuating the solar radiation collected by solar tower plants: The horizontal pathway at surface level

    Science.gov (United States)

    Elias, Thierry; Ramon, Didier; Dubus, Laurent; Bourdil, Charles; Cuevas-Agulló, Emilio; Zaidouni, Taoufik; Formenti, Paola

    2016-05-01

    Aerosols attenuate the solar radiation collected by solar tower plants (STP), along two pathways: 1) the atmospheric column pathway, between the top of the atmosphere and the heliostats, resulting in Direct Normal Irradiance (DNI) changes; 2) the grazing pathway close to surface level, between the heliostats and the optical receiver. The attenuation along the surface-level grazing pathway has been less studied than the aerosol impact on changes of DNI, while it becomes significant in STP of 100 MW or more. Indeed aerosols mostly lay within the surface atmospheric layer, called the boundary layer, and the attenuation increases with the distance covered by the solar radiation in the boundary layer. In STP of 100 MW or more, the distance between the heliostats and the optical receiver becomes large enough to produce a significant attenuation by aerosols. We used measured aerosol optical thickness and computed boundary layer height to estimate the attenuation of the solar radiation at surface level at Ouarzazate (Morocco). High variabilities in aerosol amount and in vertical layering generated a significant magnitude in the annual cycle and significant inter-annual changes. Indeed the annual mean of the attenuation caused by aerosols over a 1-km heliostat-receiver distance was 3.7% in 2013, and 5.4% in 2014 because of a longest desert dust season. The monthly minimum attenuation of less than 3% was observed in winter and the maximum of more than 7% was observed in summer.

  9. Beaming of Particles and Synchrotron Radiation in Relativistic Magnetic Reconnection

    Science.gov (United States)

    Kagan, Daniel; Nakar, Ehud; Piran, Tsvi

    2016-08-01

    Relativistic reconnection has been invoked as a mechanism for particle acceleration in numerous astrophysical systems. According to idealized analytical models, reconnection produces a bulk relativistic outflow emerging from the reconnection sites (X-points). The resulting radiation is therefore highly beamed. Using two-dimensional particle-in-cell simulations, we investigate particle and radiation beaming, finding a very different picture. Instead of having a relativistic average bulk motion with an isotropic electron velocity distribution in its rest frame, we find that the bulk motion of the particles in X-points is similar to their Lorentz factor γ, and the particles are beamed within ˜ 5/γ . On the way from the X-point to the magnetic islands, particles turn in the magnetic field, forming a fan confined to the current sheet. Once they reach the islands they isotropize after completing a full Larmor gyration and their radiation is no longer strongly beamed. The radiation pattern at a given frequency depends on where the corresponding emitting electrons radiate their energy. Lower-energy particles that cool slowly spend most of their time in the islands and their radiation is not highly beamed. Only particles that quickly cool at the edge of the X-points generate a highly beamed fan-like radiation pattern. The radiation emerging from these fast cooling particles is above the burn-off limit (˜100 MeV in the overall rest frame of the reconnecting plasma). This has significant implications for models of gamma-ray bursts and active galactic nuclei that invoke beaming in that frame at much lower energies.

  10. Cerenkov light spectrum in an optical fiber exposed to a photon or electron radiation therapy beam

    International Nuclear Information System (INIS)

    A Cerenkov signal is generated when energetic charged particles enter the core of an optical fiber. The Cerenkov intensity can be large enough to interfere with signals transmitted through the fiber. We determine the spectrum of the Cerenkov background signal generated in a poly(methyl methacrylate) optical fiber exposed to photon and electron therapeutic beams from a linear accelerator. This spectral measurement is relevant to discrimination of the signal from the background, as in scintillation dosimetry using optical fiber readouts. We find that the spectrum is approximated by the theoretical curve after correction for the wavelength dependent attenuation of the fiber. The spectrum does not depend significantly on the angle between the radiation beam and the axis of the fiber optic but is dependent on the depth in water at which the fiber is exposed to the beam.

  11. Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice

    OpenAIRE

    Lee, Seung Jun; Yi, Chin-ok; Heo, Rok Won; Song, Dae Hyun; Cho, Yu Ji; Jeong, Yi Yeong; Kang, Ki Mun; Roh, Gu Seob; Lee, Jong Deog

    2015-01-01

    Radiation-induced lung injury (RILI) is a common and unavoidable complication of thoracic radiotherapy. The current study was conducted to evaluate the ability of clarithromycin (CLA) to prevent radiation-induced pneumonitis, oxidative stress, and lung fibrosis in an animal model. C57BL/6J mice were assigned to control, irradiation only, irradiation plus CLA, and CLA only groups. Test mice received single thoracic exposures to radiation and/or oral CLA (100 mg/kg/day). Histopathologic finding...

  12. Determination of radiation attenuation coefficients of heavyweight- and normal-weight concretes containing colemanite and barite for 0.663 MeV γ-rays

    International Nuclear Information System (INIS)

    Highlights: → Some concrete were determined photon radiation absorbent for 0.663 keV. → It was concluded that barite was effective. → As known, colemanite was good absorbent to prevent for neutron transmission. → As a neutron absorbent, colemanite would be preferred to normal aggregate. - Abstract: Accurate measurements have been made to determine radiation transmission of concretes produced with barite, colemanite and normal aggregate by using beam transmission method for 0.663 MeV γ-rays energy of 137Cs radioactive isotopes by using NaI(Tl) scintillation detector. Linear and mass attenuation coefficients of thirteen heavy- and four normal-weight concretes were calculated. It was determined that the linear attenuation coefficient (μ, cm-1) decreased with colemanite concentration and increased with barite concentration in both type of the concretes. Mass attenuation coefficient values of our concretes were compared with the values proposed by the United States National Institute of Standards and Technology (NIST).

  13. Attenuation and cross-attenuation in taste aversion learning in the rat: Studies with ionizing radiation, lithium chloride and ethanol

    International Nuclear Information System (INIS)

    The preexposure paradigm was utilized to evaluate the similarity of ionizing radiation, lithium chloride and ethanol as unconditioned stimuli for the acquisition of a conditioned taste aversion. Three unpaired preexposures to lithium chloride (3.0 mEq/kg, IP) blocked the acquisition of a taste aversion when a novel sucrose solution was paired with either the injection of the same dose of lithium chloride or exposure to ionizing radiation (100 rad). Similar pretreatment with radiation blocked the acquisition of a radiation-induced aversion, but had no effect on taste aversions produced by lithium chloride (3.0 or 1.5 mEq/kg). Preexposure to ethanol (4 g/kg, PO) disrupted the acquisition of an ethanol-induced taste aversion, but not radiation- or lithium chloride-induced aversions. In contrast, preexposure to either radiation or lithium chloride attenuated an ethanol-induced taste aversion in intact rats, but not in rats with lesions of the area postrema. The results are discussed in terms of relationships between these three unconditioned stimuli and in terms of implications of these results for understanding the nature of the proximal unconditioned stimulus in taste aversion learning

  14. Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, K. M.; Schell, S.; Wilkens, J. J. [Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München (Germany)

    2013-07-26

    Laser-accelerated particles can provide a promising opportunity for radiation therapy of cancer. Potential advantages arise from combining a compact, cost-efficient treatment unit with the physical advantages in dose delivery of charged particle beams. We consider different dose delivery schemes and the required devices to design a possible treatment unit. The secondary radiation produced in several beam line elements remains a challenge to be addressed.

  15. Attenuative effects of G-CSF in radiation induced intestinal injury

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joong Sun; Gong, Eun Ji; Kim, Sung Dae; Heo, Kyu; Ryoo, Seung Bum; Yang, Kwang Mo [Dongnam Institute of Radiological and Medical Sciences, Busan (Korea, Republic of)

    2011-11-15

    Granulocyte colony stimulating factor (G-CSF) has been reported to protect from radiationinduced myelosuppression. Growing evidence suggests that G-CSF also has many important non-hematopoietic functions in other tissues, including the intestine (Kim et al., 2010; Kim et al., 2011). However, little is known about the influence of G-CSF on intestinal injury. Examination 12 hours after radiation (5 Gy) revealed that the G-CSF treated mice were significantly protected from apoptosis of jejunal crypt, compared with radiation controls. G-CSF treatment attenuated intestinal morphological changes such as decreased survival crypt, the number of villi, villous shortening, crypt depth and length of basal lamina of 10 enterocytes compared with the radiation control 3.5 days after radiation (10 Gy). G-CSF attenuated the change of peripheral blood from radiation-induced myelosuppression and displayed attenuation of mortality in lethally-irradiated (10 Gy) mice. The present results support the suggestion that G-CSF administrated prior to radiation plays an important role in the survival of irradiated mice, possibly due to the protection of hematopoietic cells and intestinal stem cells against radiation. The results indicate that G-CSF protects from radiation-mediated intestinal damage and from hematopoietic injury. G-CSF treatment may be useful clinically in the prevention of injury following radiation.

  16. Dual Laser Beam Attenuation Processing: A Method for Line-averaging of Air Temperature

    Science.gov (United States)

    Afsharnaderi, H. R.; Pishvaei, M. R.

    2009-04-01

    In local scale there is a demand to measure horizontal air temperature averaged over farming and horticulture plots for frost point monitoring and evapotranspiration calculations. Using several dry bulb thermometers is problematic. This work then attends to laser instrumentation of air thermometry. The attenuation of laser beams from Rayleigh scattering has been applied for this purpose. The ratio of attenuation quantity for two isosceles parallel laser beams (850nm and 1064nm with 5W output) led to independent line-averaging of air temperature from transmission path-lengths. Typical measurements have been executed over 400x200 m2 garden. Digital resolution is 0.1°C but spatial resolution is quite fine. One of the advantages of dual signal processing is the filtration of ambiguities caused by beam scintillations. Usage of this instrument is recommended over plane area or in green-houses and limited by topography. Applicability may be extended to other studies such as micrometeorology and propagation experiments.

  17. Radiative Transfer Model of Dust Attenuation Curves in Clumpy, Galactic Environments

    CERN Document Server

    Seon, Kwang-Il

    2016-01-01

    The attenuation of starlight by dust in galactic environments is investigated through models of radiative transfer in a spherical, clumpy ISM. Extinction properties for MW, LMC, and SMC dust types are considered. It is illustrated that the attenuation curves are primarily determined by the wavelength dependence of absorption rather than by the underlying extinction (absorption+scattering) curve. Attenuation curves consistent with the "Calzetti attenuation curve" are found by assuming the silicate-carbonaceous dust model for the MW, but with the 2175A absorption bump suppressed or absent. The discrepancy between our results and previous work that claimed the SMC-type dust to be the most likely origin of the Calzetti curve is ascribed to the difference in adopted albedos; this study uses the theoretically calculated albedos whereas the previous ones adopted empirically derived albedos from observations of reflection nebulae. It is also found that the model attenuation curves calculated with the MW dust are well...

  18. Shielding NSLS-II light source: Importance of geometry for calculating radiation levels from beam losses

    Science.gov (United States)

    Kramer, S. L.; Ghosh, V. J.; Breitfeller, M.; Wahl, W.

    2016-11-01

    Third generation high brightness light sources are designed to have low emittance and high current beams, which contribute to higher beam loss rates that will be compensated by Top-Off injection. Shielding for these higher loss rates will be critical to protect the projected higher occupancy factors for the users. Top-Off injection requires a full energy injector, which will demand greater consideration of the potential abnormal beam miss-steering and localized losses that could occur. The high energy electron injection beam produces significantly higher neutron component dose to the experimental floor than a lower energy beam injection and ramped operations. Minimizing this dose will require adequate knowledge of where the miss-steered beam can occur and sufficient EM shielding close to the loss point, in order to attenuate the energy of the particles in the EM shower below the neutron production threshold (energy on the bulk shield walls and thereby the dose penetrating the shield walls. Designing supplemental shielding near the loss point using the analytic shielding model is shown to be inadequate because of its lack of geometry specification for the EM shower process. To predict the dose rates outside the tunnel requires detailed description of the geometry and materials that the beam losses will encounter inside the tunnel. Modern radiation shielding Monte-Carlo codes, like FLUKA, can handle this geometric description of the radiation transport process in sufficient detail, allowing accurate predictions of the dose rates expected and the ability to show weaknesses in the design before a high radiation incident occurs. The effort required to adequately define the accelerator geometry for these codes has been greatly reduced with the implementation of the graphical interface of FLAIR to FLUKA. This made the effective shielding process for NSLS-II quite accurate and reliable. The principles used to provide supplemental shielding to the NSLS-II accelerators and

  19. Acoustic radiation force on a double-layer microsphere by a Gaussian focused beam

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Rongrong; Cheng, Kaixuan; Liu, Jiehui; Mao, Yiwei; Gong, Xiufen [Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093 (China); Liu, Xiaozhou, E-mail: xzliu@nju.edu.cn [Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093 (China); State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190 (China)

    2014-10-14

    A new model for calculating the radiation force on double-layer microsphere is proposed based on the ray acoustics approach. The axial acoustic radiation force resulting from a focused Gaussian beam incident on spherical shells immersed in water is examined theoretically in relation to its thickness and the contents of its double-layer. The attenuation both in the water and inside the sphere is considered in this method, which cannot be ignored while the high frequency ultrasonic is used. Results of numerical calculations are presented for fat and low density polyethylene materials, with the hollow region filled with animal oil, water, or air. These results show how the acoustic impedance and the sound velocity of both layers, together with the thickness of the shell, affect the acoustic radiation force.

  20. Study on external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT.

  1. Study on external beam radiation therapy

    International Nuclear Information System (INIS)

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT

  2. Power Beaming Leakage Radiation as a SETI Observable

    Science.gov (United States)

    Benford, James N.; Benford, Dominic J.

    2016-07-01

    The most observable leakage radiation from an advanced civilization may well be from the use of power beaming to transfer energy and accelerate spacecraft. Applications suggested for power beaming involve launching spacecraft to orbit, raising satellites to a higher orbit, and interplanetary concepts involving space-to-space transfers of cargo or passengers. We also quantify beam-driven launch to the outer solar system, interstellar precursors, and ultimately starships. We estimate the principal observable parameters of power beaming leakage. Extraterrestrial civilizations would know their power beams could be observed, and so could put a message on the power beam and broadcast it for our receipt at little additional energy or cost. By observing leakage from power beams we may find a message embedded on the beam. Recent observations of the anomalous star KIC 8462852 by the Allen Telescope Array (ATA) set some limits on extraterrestrial power beaming in that system. We show that most power beaming applications commensurate with those suggested for our solar system would be detectable if using the frequency range monitored by the ATA, and so the lack of detection is a meaningful, if modest, constraint on extraterrestrial power beaming in that system. Until more extensive observations are made, the limited observation time and frequency coverage are not sufficiently broad in frequency and duration to produce firm conclusions. Such beams would be visible over large interstellar distances. This implies a new approach to the SETI search: instead of focusing on narrowband beacon transmissions generated by another civilization, look for more powerful beams with much wider bandwidth. This requires a new approach for their discovery by telescopes on Earth. Further studies of power beaming applications should be performed, potentially broadening the parameter space of the observable features that we have discussed here.

  3. Synchrotron radiation damping, intrabeam scattering and beam-beam simulations for HE-LHC

    CERN Document Server

    Valishev, A

    2011-01-01

    The proposed High-Energy LHC project presents an unusual combination of strong synchrotron radiation (SR) damping and intrabeam scattering (IBS), which is not seen in present-day hadron colliders. The subject of investigation reported in this paper was the simulation of beam-beam effect for the HE-LHC parameters. Parameters of SR and IBS are calculated, and the luminosity evolution is simulated in the absence of beambeam interaction. Then, a weak-strong numerical simulation is used to predict the effect of beam-beam interaction on particle losses and emittance evolution.

  4. Radiation Background and Attenuation Model Validation and Development

    Energy Technology Data Exchange (ETDEWEB)

    Peplow, Douglas E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Santiago, Claudio P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-05

    This report describes the initial results of a study being conducted as part of the Urban Search Planning Tool project. The study is comparing the Urban Scene Simulator (USS), a one-dimensional (1D) radiation transport model developed at LLNL, with the three-dimensional (3D) radiation transport model from ORNL using the MCNP, SCALE/ORIGEN and SCALE/MAVRIC simulation codes. In this study, we have analyzed the differences between the two approaches at every step, from source term representation, to estimating flux and detector count rates at a fixed distance from a simple surface (slab), and at points throughout more complex 3D scenes.

  5. Radiation Shielding Design for ISOL System Beam Line

    Institute of Scientific and Technical Information of China (English)

    WANG; Feng; QIN; Jiu-chang

    2013-01-01

    The beam line of the ISOL system passes through the shielding wall and connects the HI-13 tandem accelerator.Neutron produced by tandem accelerator will affect the area of BRIF through the beam line.To protect the staff in BRIF area from radiation a shielding design of the beam line is carried out.The neutron source in the vault of tandem accelerator is the H.E Faraday cup of HI-13 tandem accelerator as showed in Fig.1.The Faraday cup is consisted of 1 mm molybdenum sheet and 10 mm

  6. Whistler-mode radiation from the Spacelab 2 electron beam

    Science.gov (United States)

    Gurnett, D. A.; Kurth, W. S.; Steinberg, J. T.; Banks, P. M.; Bush, R. I.

    1986-01-01

    During the Spacelab 2 mission the Plasma Diagnostics Package (PDP) performed a fly-around of the Shuttle at distances of up to 300 meters while an electron beam was being ejected from the Shuttle. A magnetic conjunction of the Shuttle and the PDP while the electron gun was operating in a steady (DC) mode is discussed. During this conjunction, the PDP detected a clear funnel-shaped emission that is believed to be caused by whistler-mode emission from the beam. Ray-path calculations show that the shape of the funnel can be accounted for by whistler-mode waves propagating near the resonance cone. Because the beam and waves are propagating in the same direction, the radiation must be produced by a Landau interaction with the beam. Other types of waves generated by the beam are also described.

  7. Optical Synchrotron Radiation Beam Imaging with a Digital Mask

    Energy Technology Data Exchange (ETDEWEB)

    Fiorito, R. B. [University of Maryland, College Park, MD (United States); Zhang, H. D. [University of Maryland, College Park, MD (United States); Corbett, W. J. [SLAC, Menlo Park, CA (United States); Fisher, A. S. [SLAC, Menlo Park, CA (United States); Mok, W. Y. [SLAC, Menlo Park, CA (United States); Tian, K. [SLAC, Menlo Park, CA (United States); Douglas, D. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Wilson, F. G. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Zhang, S. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Mitsuhashi, T. M. [KEK, Tsukuba (Japan); Shkvarunets, A. G. [University of Maryland, College Park, MD (United States)

    2012-11-01

    We have applied a new imaging/optical masking technique, which employs a digital micro-mirror device (DMD) and optical synchrotron radiation (OSR), to perform high dynamic range (DR) beam imaging at the JLAB Energy Recovery Linac and the SLAC/SPEAR3 Synchrotron Light Source. The OSR from the beam is first focused onto the DMD to produce a primary image; selected areas of this image are spatially filtered by controlling the state of individual micro-mirrors; and finally, the filtered image is refocused onto a CCD camera. At JLAB this technique has been used successfully to view the beam halo with a DR ~ 105. At SPEAR3 the DMD was used to filter out the bright core of the stored beam to study the turn-by-turn dynamics of the 10-3 weaker injected beam. We describe the optical performance, present limitations and our plans to improve the DR of both experimental systems.

  8. Spectral properties of Compton inverse radiation: Application of Compton beams

    CERN Document Server

    Bulyak, Eugene

    2013-01-01

    Compton inverse radiation emitted due to backscattering of laser pulses off the relativistic electrons possesses high spectral density and high energy of photons - in hard x-ray up to gamma-ray energies - because of short wavelength of laser radiation as compared with the classical electromagnetic devices such as undulators. In this report, the possibility of such radiation to monochromatization by means of collimation is studied. Two approaches have been considered for the description of the spectral-angular density of Compton radiation based on the classical field theory and on the quantum electrodynamics. As is shown, both descriptions produce similar total spectra. On the contrary, angular distribution of the radiation is different: the classical approach predicted a more narrow radiation cone. Also proposed and estimated is a method of the `electronic' monochromatization based on the electronic subtraction of the two images produced by the electron beams with slightly different energies. A `proof-of-prin...

  9. Curcumin Attenuates Gamma Radiation Induced Intestinal Damage in Rats

    International Nuclear Information System (INIS)

    Small Intestine exhibits numerous morphological and functional alterations during radiation exposure. Oxidative stress, a factor implicated in the intestinal injury may contribute towards some of these alterations. The present work was designed to evaluate the efficacy of curcumin, a yellow pigment of turmeric on y-radiation-induced oxidative damage in the small intestine by measuring alterations in the level of thiobarbituric acid reactive substances (TSARS), serotonin metabolism, catecholamine levels, and monoamine oxidase (MAO) activity in parallel to changes in the architecture of intestinal tissues. In addition, monoamine level, MAO activity and TSARS level were determined in the serum. Curcumin was supplemented orally via gavages, to rats at a dose of (45 mg/ Kg body wt/ day) for 2 weeks pre-irradiation and the last supplementation was 30 min pre exposure to 6.5 Gy gamma radiations (applied as one shot dose). Animals were sacrificed on the 7th day after irradiation. The results demonstrated that, whole body exposure of rats to ionizing radiation has induced oxidative damage in small intestine obvious by significant increases of TSARS content, MAO activity and 5-hydroxy indole acetic acid (5-HIAA) and by significant decreases of serotonin (5-HT), dopamine (DA), norepinephrine (NE) and epinephrine (EPI) levels. In parallel histopathological studies of the small intestine of irradiated rats through light microscopic showed significant decrease in the number of villi, villus height, mixed sub mucosa layer with more fibres and fibroblasts. Intestinal damage was in parallel to significant alterations of serum MAO activity, TBARS, 5-HT, DA, NE and EPI levels. Administration of curcumin before irradiation has significantly improved the levels of monoamines in small intestine and serum of irradiated rats, which was associated with significant amelioration in MAO activity and TBARS contents

  10. Calculating the background radiation in the vicinity of the beam catchers of the ELBE radiation source

    International Nuclear Information System (INIS)

    The ELBE radiation sources comprises beam catchers in the experimenting sites which absorb the primary electron beam as well as the generated secondary radiation. The beam catcher consists of an ultrapure graphite absorber enclosed in a water-cooled stainless steel shell. Background radiation is shielded by iron, lead and heavy concrete. The beam parameters and the position of the beam catchers differ between experimenting sites. In order to determine the dose dependence of photon and neutron fluence and the dose equivalent at the cooling shell of the beam catcher, simulations were carried out using the FLUKA code. Radiation energies of 20 MeV and 50 MeV and electron fluxes of 1 mA were considered. The spatial and energetic distributions of the dose rate equivalent provide a basis for dimensioning of the radiation shields. The calculated distributions of the energy dose rate in the beam catcher serve as a basis for assessing thermal loads on materials and for designing the cooling system. (orig.)

  11. Electron Beam Instrumentation Techniques Using Coherent Radiation

    Science.gov (United States)

    Wang, D. X.

    1997-05-01

    In recent years, there has been increasing interest in short electron bunches for different applications such as short wavelength FELs, linear colliders, advanced accelerators such as laser or plasma wakefield accelerators, and Compton backscattering X-ray sources. A short bunch length is needed to meet various requirements such as high peak current, low momentum spread, high luminosity, small ratio of bunch length to plasma wavelength, or accurate timing. Meanwhile, much progress has been made on photoinjectors and different magnetic and RF bunching schemes to produce very short bunches. Measurement of those short bunches becomes essential to develop, characterize, and operate such demanding machines. Conventionally, bunch duration of short electron bunches is measured by transverse RF deflecting cavities or streak camera. With such devices it becomes very challenging to measure bunch length down to a few hundred femtoseconds. Many frequency domain techniques have been recently developed, based on a relation between bunch profile and coherent radiation spectrum. These techniques provide excellent performance for short bunches. In this paper, coherent radiation and its applications to bunch length measurement will be discussed. A strategy for bunch length control at Jefferson Lab will be presented, which includes a noninvasive coherent synchrotron radiation (CSR) monitor, a zero-phasing technique used to calibrate the CSR detector, and phase transfer measurement used to correct RF phase drifts.

  12. Short Electron Beam Bunch Characterization Through Measurement of Terahertz Radiation

    CERN Document Server

    Zhang, Shukui; Douglas, David; Shinn, Michelle D; Williams, Gwyn

    2004-01-01

    Characterization of the electron beam bunch length of the upgrade FEL at Jefferson Lab was performed by analyzing the FTIR spectra of the coherent terahertz pulses. The results are compared with autocorrelation from a scanning polarization autocorrelator that measures the optical transition radiation. The limitations of the different methods to such a characterization are presented in this paper.

  13. A phase-space beam position monitor for synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Samadi, Nazanin, E-mail: nazanin.samadi@usask.ca [University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK (Canada); Bassey, Bassey; Martinson, Mercedes [University of Saskatchewan, 116 Science Place, Saskatoon, SK (Canada); Belev, George; Dallin, Les; Jong, Mark de [Canadian Light Source, 44 Innovation Boulevard, Saskatoon, SK (Canada); Chapman, Dean [University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK (Canada)

    2015-06-25

    A system has been developed to measure the vertical position and angle of the electron beam at a single location from a synchrotron source. The system uses a monochromator tuned to the absorption edge of a contrast material and has a sensitivity comparable with other beam position monitors. The stability of the photon beam position on synchrotron beamlines is critical for most if not all synchrotron radiation experiments. The position of the beam at the experiment or optical element location is set by the position and angle of the electron beam source as it traverses the magnetic field of the bend-magnet or insertion device. Thus an ideal photon beam monitor would be able to simultaneously measure the photon beam’s position and angle, and thus infer the electron beam’s position in phase space. X-ray diffraction is commonly used to prepare monochromatic beams on X-ray beamlines usually in the form of a double-crystal monochromator. Diffraction couples the photon wavelength or energy to the incident angle on the lattice planes within the crystal. The beam from such a monochromator will contain a spread of energies due to the vertical divergence of the photon beam from the source. This range of energies can easily cover the absorption edge of a filter element such as iodine at 33.17 keV. A vertical profile measurement of the photon beam footprint with and without the filter can be used to determine the vertical centroid position and angle of the photon beam. In the measurements described here an imaging detector is used to measure these vertical profiles with an iodine filter that horizontally covers part of the monochromatic beam. The goal was to investigate the use of a combined monochromator, filter and detector as a phase-space beam position monitor. The system was tested for sensitivity to position and angle under a number of synchrotron operating conditions, such as normal operations and special operating modes where the photon beam is intentionally altered

  14. Attenuation of Ultraviolet Radiation by Dust in Interstellar Clouds

    Science.gov (United States)

    Escalante, V.

    1994-07-01

    Se han obtenido soluciones de la ecuación de transporte para la dispersión coherente, no conservativa y anisotrópica para estimar la precisión de métodos aproximados, usados en modelos de nubes en que la luz es atenuada principalmente por el polvo. En los cálculos se ha aplicado el metodo de armónicos esféricos para distintos parámetros del polvo. Se ha explorado la posibilidad de descubrir cambios en las caracterísiticas del polvo mediante observaciones de regiones fotodisociadas. Se muestra que para altos valores del albedo de dispersión simple y del parametro de asimetria de Ia función de fase que son adecuados para el polvo galáctico, no es posible determinar variaciones de más de un factor de 2 en el cociente de gas a polvo. Solutions to the transfer equation for coherent, non-conservative, anisotropic scattering have been obtained in order to estimate the accuracy of approximate methods used in models of clouds where light is attenuated mostly by dust. In the calculations the spherical harmonic method has been applied for different grain parameters. The possibility of discovering changes of dust characteristics through observations of photodissociation regions has been considered. It is shown that for the high values of the single scattering albedo and the asymmetry parameter of the phase function for redistribution that appear to be appropriate for galactic dust, it is not possible to determine variations of more than a factor of 2 in the gas to dust ratio.

  15. Liquid deuterium neutron attenuator for broad-band photon beam facility

    International Nuclear Information System (INIS)

    The photo-production facility at Fermilab uses a two section liquid deuterium attenuator, 103 feet in length, to reduce the neutron flux and produce a pure high energy photon beam. The facility is located in the Proton East experimental hall, and includes nine 10 foot long sweeping magnets. A unique refrigeration system supplies mechanically refrigerated helium gas trace cooling to condense deuterium directly in a flask. The control system permits remote operation of the cryogenic system and also acts as an interface to the Proton Area operations computer. The computer can be used to monitor the operating parameters and for partial control of the system. The facility is presently in use as part of the Proton Area experimental program. (auth)

  16. Study of radiation detectors response in standard X, gamma and beta radiation standard beams

    International Nuclear Information System (INIS)

    The response of 76 Geiger-Mueller detectors, 4 semiconductor detectors and 34 ionization chambers were studied. Many of them were calibrated with gamma radiation beams (37Cs and 60Co), and some of them were tested in beta radiation (90Sr+9'0Y e 204Tl) and X radiation (N-60, N-80, N-100, N-150) beams. For all three types of radiation, the calibration factors of the instruments were obtained, and the energy and angular dependences were studied. For beta and gamma radiation, the angular dependence was studied for incident radiation angles of 0 deg and +- 45 deg. The curves of the response of the instruments were obtained over an angle interval of 0 deg to +- 90 deg, for gamma, beta and X radiations. The calibration factors obtained for beta radiation were compared to those obtained for gamma radiation. For gamma radiation, 24 of the 66 tested Geiger-Mueller detectors presented results for the energy dependence according to international recommendation of ISO 4037-2 and 56 were in accordance with the Brazilian ABNT 10011 recommendation. The ionization chambers and semiconductors were in accordance to national and international recommendations. All instruments showed angular dependence less than 40%. For beta radiation, the instruments showed unsatisfactory results for the energy dependence and angular dependence. For X radiation, the ionization chambers presented results for energy dependence according to the national recommendation, and the angular dependence was less than 40%. (author)

  17. Radiation Tolerance of Cryogenic Beam Loss Monitor Detectors

    CERN Document Server

    Kurfuerst, C; Bartosik, M; Dehning, B; Eisel, T; Sapinski, M; Eremin, V; Verbitskaya, E; Fabjan, C; Griesmayer, E

    2013-01-01

    At the triplet magnets, close to the interaction regions of the LHC, the current Beam Loss Monitoring system is sensitive to the particle showers resulting from the collision of the two beams. For the future, with beams of higher energy and intensity resulting in higher luminosity, distinguishing between these interaction products and possible quench-provoking beam losses from the primary proton beams will be challenging. Investigations are therefore underway to optimise the system by locating the beam loss detectors as close as possible to the superconducting coils of the triplet magnets. This means putting detectors inside the cold mass in superfluid helium at 1.9 K. Previous tests have shown that solid state diamond and silicon detectors as well as liquid helium ionisation chambers are promising candidates. This paper will address the final open question of their radiation resistance for 20 years of nominal LHC operation, by reporting on the results from high irradiation beam tests carried out at CERN in a...

  18. External Beam Radiation in Differentiated Thyroid Carcinoma

    Directory of Open Access Journals (Sweden)

    Salem Billan

    2016-01-01

    Full Text Available The treatment of differentiated thyroid carcinoma (DTC is surgery followed in some cases by adjuvant treatment, mostly with radioactive iodine (RAI. External beam radiotherapy (EBRT is less common and not a well-established treatment modality in DTC. The risk of recurrence depends on three major prognostic factors: extra-thyroid extension, patient’s age, and tumor with reduced iodine uptake. Increased risk for recurrence is a major factor in the decision whether to treat the patient with EBRT. Data about the use of EBRT in DTC are limited to small retrospective studies. Most series have demonstrated an increase in loco-regional control. The risk/benefit from giving EBRT requires careful patient selection. Different scoring systems have been proposed by different investigators and centers. The authors encourage clinicians treating DTC to become familiarized with those scoring systems and to use them in the management of different cases. The irradiated volume should include areas of risk for microscopic disease. Determining those areas in each case can be difficult and requires detailed knowledge of the surgery and pathological results, and also understanding of the disease-spreading pattern. Treatment with EBRT in DTC can be beneficial, and data support the use of EBRT in high-risk patients. Randomized controlled trials are needed for better confirmation of the role of EBRT.

  19. Generation and modelling of megavoltage photon beams for contrast-enhanced radiation therapy

    Science.gov (United States)

    Robar, J. L.

    2006-11-01

    Contrast-enhanced radiation therapy (CERT) is a treatment approach involving the irradiation of tumours containing high atomic number (Z) contrast media, using low-quality x-ray beams. This work describes the experimental generation of x-ray beams using a linear accelerator with low-Z target materials (beryllium and aluminium), in order to produce photon energy spectra appropriate for CERT. Measurements were made to compare the experimental beams to conventional linear accelerator photon beams in terms of per cent depth dose. Monte Carlo simulation was used to model the generation of each beam, and models were validated against experimental measurement. Validated models were used to demonstrate changes in photon spectra as well as to quantify the variation of tumour dose enhancement with iodinated contrast medium concentration in a simulated tumour volume. Finally, the ratio of the linear attenuation coefficient for iodinated contrast medium relative to water was determined experimentally as a function of iodine concentration. Beams created with low-Z targets show significant changes in energy spectra compared to conventional beams. For the 4 MeV/Be beam, for example, 33% of photons have energies below 60 keV. Measurements and calculation show that both the linear attenuation coefficient ratio and dose enhancement factor (DEF) increase most rapidly at concentrations below 46 mg I ml-1. There is a significant dependence of DEF on electron energy and a lesser dependence on target material. The 4 MeV/Be beam is the most promising in terms of magnitude of DEF—for example, DEF values of 1.16 and 1.29 are obtained for concentrations of 20 mg I ml-1 and 50 mg I ml-1, respectively. DEF will increase or decrease, respectively, for shallower or deeper tumours at a rate of approximately 1.1% cm-1. In summary, we show that significant dose enhancement is possible by altering the linear accelerator target and filtration, but the magnitude is highly dependent on contrast

  20. Radiation protection system at the RIKEN RI beam factory.

    Science.gov (United States)

    Uwamino, Y; Fujita, S; Sakamoto, H; Ito, S; Fukunishi, N; Yabutani, T; Yamano, T; Fukumura, A

    2005-01-01

    The RIKEN RI (radioactive isotope) Beam Factory is scheduled to commence operations in 2006, and its maximum energy will be 400 MeV u(-1) for ions lighter than Ar and 350 MeV u(-1) for uranium. The beam intensity will be 1 pmicroA (6 x 10(12) particles s(-1)) for any element at the goal. For the hands-on-maintenance and the rational shield thickness of the building, the beam loss must be controlled with several kinds of monitors. Three types of radiation monitors will be installed. The first one consists of a neutron dose equivalent monitor and an ionisation chamber, which are commercially available area monitors. The second one is a conventional hand-held dose equivalent monitor wherein the logarithmic signal is read by a programmable logic controller based on the radiation safety interlock system (HIS). The third one is a simple plastic scintillator called a beam loss monitor. All the monitors have threshold levels for alarm and beam stop, and HIS reads all these signals.

  1. Monoenergetic proton beams accelerated by a radiation pressure driven shock

    CERN Document Server

    Palmer, C A J; Pogorelsky, I; Babzien, M; Dudnikova, G I; Ispiriyan, M; Polyanskiy, M N; Schreiber, J; Shkolnikov, P; Yakimenko, V; Najmudin, Z

    2010-01-01

    High energy ion beams (> MeV) generated by intense laser pulses promise to be viable alternatives to conventional ion beam sources due to their unique properties such as high charge, low emittance, compactness and ease of beam delivery. Typically the acceleration is due to the rapid expansion of a laser heated solid foil, but this usually leads to ion beams with large energy spread. Until now, control of the energy spread has only been achieved at the expense of reduced charge and increased complexity. Radiation pressure acceleration (RPA) provides an alternative route to producing laser-driven monoenergetic ion beams. In this paper, we show the interaction of an intense infrared laser with a gaseous hydrogen target can produce proton spectra of small energy spread (~ 4%), and low background. The scaling of proton energy with the ratio of intensity over density (I/n) indicates that the acceleration is due to the shock generated by radiation-pressure driven hole-boring of the critical surface. These are the fi...

  2. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    CERN Document Server

    Povoli, Marco; Bravin, Alberto; Cornelius, Iwan; Bräuer-Krisch, Elke; Fournier, Pauline; Hansen, Thor-Erik; Kok, Angela; Lerch, Michael; Monakhov, Edouard; Morse, John; Petasecca, Marco; Requardt, Herwig; Rosenfeld, Anatoly; Röhrich, Dieter; Sandaker, Heidi; Salomé, Murielle; Stugu, Bjarne

    2015-01-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any...

  3. Radiation monitoring and beam dump system of the OPAL silicon microvertex detector

    CERN Document Server

    Braibant, S

    1997-01-01

    The OPAL microvertex silicon detector radiation monitoring and beam dump system is described. This system was designed and implemented in order to measure the radiation dose received at every beam crossing and to induce a fast beam dump if the radiation dose exceeds a given threshold.

  4. Terahertz plasmonic laser radiating in an ultra-narrow beam

    CERN Document Server

    Wu, Chongzhao; Reno, John L; Kumar, Sushil

    2016-01-01

    Plasmonic lasers (spasers) generate coherent surface-plasmon-polaritons (SPPs) and could be realized at subwavelength dimensions in metallic cavities for applications in nanoscale optics. Plasmonic cavities are also utilized for terahertz quantum-cascade lasers (QCLs), which are the brightest available solid-state sources of terahertz radiation. A long standing challenge for spasers is their poor coupling to the far-field radiation. Unlike conventional lasers that could produce directional beams, spasers have highly divergent radiation patterns due to their subwavelength apertures. Here, we theoretically and experimentally demonstrate a new technique for implementing distributed-feedback (DFB) that is distinct from any other previously utilized DFB schemes for semiconductor lasers. The so-termed antenna-feedback scheme leads to single-mode operation in plasmonic lasers, couples the resonant SPP mode to a highly directional far-field radiation pattern, and integrates hybrid SPPs in surrounding medium into the ...

  5. Off-Axis Undulator Radiation for CLIC Drive Beam Diagnostics

    CERN Document Server

    Jeff, A; Welsch, CP

    2013-01-01

    The Compact LInear Collider (CLIC) will use a novel acceleration scheme in which energy extracted from a very intense beam of relatively low-energy electrons (the Drive Beam) is used to accelerate a lower intensity Main Beam to very high energy. The high intensity of the Drive Beam, with pulses of more than 1015 electrons, poses a challenge for conventional profile measurements such as wire scanners. Thus, new non-invasive profile measurements are being investigated. In this paper we propose the use of relatively inexpensive permanent-magnet undulators to generate off-axis visible Synchrotron Radiation from the CLIC Drive Beam. The field strength and period length of the undulator should be designed such that the on-axis undulator wavelength is in the ultra-violet. A smaller but still useable amount of visible light is then generated in a hollow cone. This light can be reflected out of the beam pipe by a ring-shaped mirror placed downstream and imaged on a camera. In this contribution, results of SRW and ZEMA...

  6. ATEN, a didactic program to study gamma radiation attenuation through matter

    CERN Document Server

    Paniagua, J; Rio, M D; Jiménez, A; Baeza, A; Miro, C

    1995-01-01

    A simulation model is described, which is based on the Monte-Carlo technique, for the computer study of the attenuation which gamma radiation undergoes as it interacts with matter. The interaction modes that were considered are exclusively the photoelectric, Compton, and pair production effects. A computer program, ATEN, has been developed for this model, which allows one to obtain the attenuation coefficient of an absorbing material for gamma radiation of known energy, using cross sections of those processes considered in the model for energies between 0.1 and 10 MeV. ATEN was developed for didactic purposes and was designed to be used as an interesting support for laboratory practical classes for undergraduates in their first university courses. (author)

  7. Measurement of the linear attenuation coefficients of breast tissues by synchrotron radiation computed tomography

    Science.gov (United States)

    Chen, R. C.; Longo, R.; Rigon, L.; Zanconati, F.; De Pellegrin, A.; Arfelli, F.; Dreossi, D.; Menk, R.-H.; Vallazza, E.; Xiao, T. Q.; Castelli, E.

    2010-09-01

    The measurement of the linear attenuation coefficients of breast tissues is of fundamental importance in the field of breast x-ray diagnostic imaging. Different groups have evaluated the linear attenuation coefficients of breast tissues by carrying out direct attenuation measurements in which the specimens were thin and selected as homogeneous as possible. Here, we use monochromatic and high-intensity synchrotron radiation computed tomography (SR CT) to evaluate the linear attenuation coefficients of surgical breast tissues in the energy range from 15 to 26.5 keV. X-ray detection is performed by a custom digital silicon micro-strip device, developed in the framework of the PICASSO INFN experiment. Twenty-three human surgical breast samples were selected for SR CT and histological study. Six of them underwent CT, both as fresh tissue and after formalin fixation, while the remaining 17 were imaged only as formalin-fixed tissues. Our results for fat and fibrous tissues are in good agreement with the published values. However, in contrast to the published data, our measurements show no significant differences between fibrous and tumor tissues. Moreover, our results for fresh and formalin-fixed tissues demonstrate a reduction of the linear attenuation coefficient for fibrous and tumor tissues after fixation.

  8. Measurement of the linear attenuation coefficients of breast tissues by synchrotron radiation computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Chen, R C; Xiao, T Q [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai (China); Longo, R; Arfelli, F; Castelli, E [Department of Physics, University of Trieste, Trieste (Italy); Rigon, L; Dreossi, D; Menk, R-H; Vallazza, E [INFN, Sezione di Trieste, Trieste (Italy); Zanconati, F; De Pellegrin, A, E-mail: rongchang.chen@gmail.co [Department of Pathologic Anatomy, University of Trieste, Trieste (Italy)

    2010-09-07

    The measurement of the linear attenuation coefficients of breast tissues is of fundamental importance in the field of breast x-ray diagnostic imaging. Different groups have evaluated the linear attenuation coefficients of breast tissues by carrying out direct attenuation measurements in which the specimens were thin and selected as homogeneous as possible. Here, we use monochromatic and high-intensity synchrotron radiation computed tomography (SR CT) to evaluate the linear attenuation coefficients of surgical breast tissues in the energy range from 15 to 26.5 keV. X-ray detection is performed by a custom digital silicon micro-strip device, developed in the framework of the PICASSO INFN experiment. Twenty-three human surgical breast samples were selected for SR CT and histological study. Six of them underwent CT, both as fresh tissue and after formalin fixation, while the remaining 17 were imaged only as formalin-fixed tissues. Our results for fat and fibrous tissues are in good agreement with the published values. However, in contrast to the published data, our measurements show no significant differences between fibrous and tumor tissues. Moreover, our results for fresh and formalin-fixed tissues demonstrate a reduction of the linear attenuation coefficient for fibrous and tumor tissues after fixation.

  9. Shielding and Radiation Protection in Ion Beam Therapy Facilities

    Science.gov (United States)

    Wroe, Andrew J.; Rightnar, Steven

    Radiation protection is a key aspect of any radiotherapy (RT) department and is made even more complex in ion beam therapy (IBT) by the large facility size, secondary particle spectra and intricate installation of these centers. In IBT, large and complex radiation producing devices are used and made available to the public for treatment. It is thus the responsibility of the facility to put in place measures to protect not only the patient but also the general public, occupationally and nonoccupationally exposed personnel working within the facility, and electronics installed within the department to ensure maximum safety while delivering maximum up-time.

  10. Seismic Wave Attenuation Estimated from Tectonic Tremor and Radiated Energy in Tremor for Various Subduction Zones

    Science.gov (United States)

    Yabe, S.; Baltay, A.; Ide, S.; Beroza, G. C.

    2013-12-01

    Ground motion prediction is an essential component of earthquake hazard assessment. Seismic wave attenuation with distance is an important, yet difficult to constrain, factor for such estimation. Using the empirical method of ground motion prediction equations (GMPEs), seismic wave attenuation with distance, which includes both the effect of anelastic attenuation and scattering, can be estimated from the distance decay of peak ground velocity (PGV) or peak ground acceleration (PGA) of ordinary earthquakes; however, in some regions where plate-boundary earthquakes are infrequent, such as Cascadia and Nankai, there are fewer data with which to constrain the empirical parameters. In both of those subduction zones, tectonic tremor occurs often. In this study, we use tectonic tremor to estimate the seismic wave attenuation with distance, and in turn use the attenuation results to estimate the radiated seismic energy of tremor. Our primary interest is in the variations among subduction zones. Ground motion attenuation and the distribution of released seismic energy from tremors are two important subduction zone characteristics. Therefore, it is very interesting to see whether there are variations of these parameters in different subduction zones, or regionally within the same subduction zone. It is also useful to estimate how much energy is released by tectonic tremor from accumulated energy to help understand subduction dynamics and the difference between ordinary earthquakes and tremor. We use the tectonic tremor catalog of Ide (2012) in Nankai, Cascadia, Mexico and southern Chile. We measured PGV and PGA of individual tremor bursts at each station. We assume a simple GMPE relationship and estimate seismic attenuation and relative site amplification factors from the data. In the Nankai subduction zone, there are almost no earthquakes on the plate interface, but intra-slab earthquakes occur frequently. Both the seismic wave attenuation with distance and the site

  11. Measurement of 60CO gamma radiation induced attenuation in multimode step-index POF at 530 nm

    Directory of Open Access Journals (Sweden)

    Kovačević Milan S.

    2013-01-01

    Full Text Available As optical fibres are used ever more extensively in space applications, nuclear industry, medicine and high-energy physics experiments, it has become essential to investigate the influence of ionizing radiation on their characteristics. In this work, the radiation-induced attenuation at 530 nm is investigated experimentally in step-index multimode polymethyl-methacrylate plastic optical fibres exposed to low dose-rate gamma radiation. Cumulative doses ranged from 50 Gy to 500 Gy. The radiation induced attenuation has been empirically found to obey the power law RIA= aDb, where D is the total radiation dose and a and b are the constants determined by fitting.

  12. Development of resistant materials to beam impact and radiation damage

    Science.gov (United States)

    Kawai, Masayoshi; Kokawa, Hiroyuki; Okamura, Hiroshi; Kawasaki, Akira; Yamamura, Tsutomu; Hara, Nobuyoshi; Akao, Noboru; Futakawa, Masatoshi; Kikuchi, Kenji

    2006-09-01

    Materials that have strong resistance to both beam impact (or shock-wave) and radiation damage are required for the beam target of an intense accelerator and space applications. Recently, Futakawa et al. found in their experiments that Kolsterising specimens have a stronger resistance to pitting than SS316 CW. A similar effect can be expected for other hardening treatments, and new material development is hopeful. Accordingly, we have started the development of high-performance materials by organizing the project team from KEK, JAEA and universities. In this paper, the scope of the project is introduced. Recent topics involve the development of intergranular crack (IGC)-resistant austenitic stainless-steel, AlN-TiN ceramics and cladding techniques of thin tantalum or CrN film on a tungsten target by means of a molten-salt method and ion-beam-enhanced deposition. New observations on corrosion resistance are presented.

  13. Reinfection immunity in schistosomiasis. With special reference to immunity induced by radiation attenuated Cercariae

    Energy Technology Data Exchange (ETDEWEB)

    Kamiya, Haruo

    1987-07-01

    Schistosomiasis is one of the most important parasitic diseases in the world, especially in endemic areas of developing countries. This situation has prompted parasitologist to attempt intensive researches on immune mechanisms, especially those of reinfection immunity associated with eliminating challenge infection. The current knowledge of reinfection immunity against Schistosoma spp. infection was therefore reviewed briefly and discussed with special reference to our data on protective immune responses induced by radiation-attenuated cercarial infection. A recently developed technique of compressed organ autoradiography (COA) has contributed to assessing parasite attrition in immune animals following challenge infection. Our study using COA has demonstrated that major attrition of schistosomula from challenge infection occurs in the skin of CBA/Ca mice vaccinated with 20 Krad gamma radiation-attenuated cercariae of S. mansoni, while in both lungs and liver of similarly vaccinated guinea pig model. Furthermore, gamma-irradiation to cercariae affected their migration potential and surface-antigen profiles. The immunizing stimuli of gamma radiation-attenuated cercariae profoundly affected the expression of responsiveness in vaccinated animals. The change in antigenic profiles and migration potential of those vaccinating population was discussed in relation to the kinetics of reinfection immunity induced in vaccinated amimal models. These works might provide a base line data to develop a practical vaccine for schistosomiasis using defined antigens. It must be emphasized that these vaccines could serve as a practical prophylactic measure for schistosomiasis in the endemic areas, even if the vaccines fail to induce sterilizing immunity. (author). 141 refs.

  14. Beam Loss Position Monitor Using Cerenkov Radiation in Optical Fibers

    CERN Document Server

    Körfer, M

    2005-01-01

    Single pass Free Electron Lasers SASE-FELs are developed for high brightness and short wavelength applications. The VUV-FEL at DESY will reach an average beam power of about 72 kW. To avoid particle losses in the radiation sensitive undulators a collimator system is installed. However, the proper operation of the collimator system needs to be measured with a beam loss monitor. Conventional radiation sensor systems are not suited for the VUV-FEL undulators, because the free space in the undulator gap is less than 1 mm. A Beam Loss Position Monitor (BLPM) based on Cerenkov light in optical fibers allows the monitoring of losses inside the undulator. Electrons with energies above 175 keV generate Cerenkov light during their penetration of the optical fiber. The fast response of the Cerenkov signal is detected with photomultipliers at the end of the irradiated fibers. The beam loss position along the section of interest can be determinate by exploiting the system trigger (bunch clock) of the accelerator system. T...

  15. Radiation Shielding Analysis of Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    The objective of this technical report are to establish the radiation shielding technology of a high-energy electron accelerator to the facilities which utilize with electron beam. The technologies of electron beam irradiation(300 KeV -10 MeV) demand on the diverse areas of material processing, surface treatment, treatments on foods or food processing, improvement of metal properties, semiconductors, and ceramics, sterilization of medical goods and equipment, treatment and control of contamination and pollution, and so on. In order to acquire safety design for the protection of personnel from the radiations produced by electron beam accelerators, it is important to develop the radiation shielding analysis technology. The shielding analysis are carried out by which define source term, calculation modelling and computer calculations for 2 MeV and 10 MeV accelerators. And the shielding analysis for irradiation dump shield with 10 MeV accelerators are also performed by solving the complex 3-D geometry and long computer run time problem. The technology development of shielding analysis will be contributed to extend the further high energy accelerator development

  16. Producing acoustic 'Frozen Waves': simulated experiments with diffraction/attenuation resistant beams in lossy media.

    Science.gov (United States)

    Prego-Borges, José L; Zamboni-Rached, Michel; Recami, Erasmo; Costa, Eduardo Tavares

    2014-08-01

    The so-called Localized Waves (LW), and the "Frozen Waves" (FW), have raised significant attention in the areas of Optics and Ultrasound, because of their surprising energy localization properties. The LWs resist the effects of diffraction for large distances, and possess an interesting self-reconstruction -self-healing- property (after obstacles with size smaller than the antenna's); while the FWs, a sub-class of LWs, offer the possibility of arbitrarily modeling the longitudinal field intensity pattern inside a prefixed interval, for instance 0⩽z⩽L, of the wave propagation axis. More specifically, the FWs are localized fields "at rest", that is, with a static envelope (within which only the carrier wave propagates), and can be endowed moreover with a high transverse localization. In this paper we investigate, by simulated experiments, various cases of generation of ultrasonic FW fields, with the frequency of f0=1 MHz in a water-like medium, taking account of the effects of attenuation. We present results of FWs for distances up to L=80 mm, in attenuating media with absorption coefficient α in the range 70⩽α⩽170 dB/m. Such simulated FW fields are constructed by using a procedure developed by us, via appropriate finite superpositions of monochromatic ultrasonic Bessel beams. We pay due attention to the selection of the FW parameters, constrained by the rather tight restrictions imposed by experimental Acoustics, as well as to some practical implications of the transducer design. The energy localization properties of the Frozen Waves can find application even in many medical apparatus, such as bistouries or acoustic tweezers, as well as for treatment of diseased tissues (in particular, for the destruction of tumor cells, without affecting the surrounding tissues; also for kidney stone shuttering, etc.).

  17. Measure of the attenuation curve of a beam of X-rays with TLD-100 dosimeters of LiF; Medicion de la curva de atenuacion de un haz de rayos X con dosimetros TLD-100 de LiF

    Energy Technology Data Exchange (ETDEWEB)

    Bonzi, E. V.; Mainardi, R. T. [Universidad Nacional de Cordoba, Facultad de Matematica, Astronomia y Fisica, Av. Haya de la Torre y Av. Medina Allende s/n, Ciudad Universitaria, Cordoba (Argentina); Germanier, A. [Ministerio de Ciencia y Tecnologia, Ceprocor, Unidad de Estudios Fisicos, Alvarez de Arenas 230, X5004AAP Barrio Juniors, Cordoba (Argentina); Delgado, V. [Universidad Complutense de Madrid, Departamento de Fisica Medica, Ciudad Universitaria, 28040 Madrid (Spain)

    2011-10-15

    The attenuation curve of a beam of X-rays represents the beam intensity in function of the attenuator thickness interposed between the source and the detector. To know with the major possible precision the attenuation curve is indispensable in procedures of spectral reconstruction. Their periodic measuring also offers valuable information on the correct operation of a tube of X-rays, diagnostic or therapy, when not have a specific detector for that activity. In this work was measured the attenuation curve of a tube of X-rays operated to 50 kV and 0.5 ma, using existent elements in any diagnostic or therapy laboratory with radiations. In the measures commercial aluminum foil was used, bent until 24 times and thermoluminescent dosimeters TLD 100 - LiF. Also, for comparison, was measured this attenuation curve with an ionization chamber brand Capintec model 192. Was determined by X-rays fluorescence the composition of the aluminium foil, since the present elements in the alloy can to affect the form of the attenuation curve. It is interesting to observe that these elements are in very low proportion (ppm) that they do not alter the attenuation capacity of the pure aluminium. Finally in a precision balance we weigh a big piece (30 cm x 100 cm) of aluminium foil and we obtained the thickness in g/c m2. It is possible to obtain attenuation curves of a beam of X-rays, with a high precision procedure and reproducibility. The use of TLD-100 dosimeters of LiF or similar makes that this activity was also quick and simple. (Author)

  18. Towards a quantitative, measurement-based estimate of the uncertainty in photon mass attenuation coefficients at radiation therapy energies.

    Science.gov (United States)

    Ali, E S M; Spencer, B; McEwen, M R; Rogers, D W O

    2015-02-21

    In this study, a quantitative estimate is derived for the uncertainty in the XCOM photon mass attenuation coefficients in the energy range of interest to external beam radiation therapy-i.e. 100 keV (orthovoltage) to 25 MeV-using direct comparisons of experimental data against Monte Carlo models and theoretical XCOM data. Two independent datasets are used. The first dataset is from our recent transmission measurements and the corresponding EGSnrc calculations (Ali et al 2012 Med. Phys. 39 5990-6003) for 10-30 MV photon beams from the research linac at the National Research Council Canada. The attenuators are graphite and lead, with a total of 140 data points and an experimental uncertainty of ∼0.5% (k = 1). An optimum energy-independent cross section scaling factor that minimizes the discrepancies between measurements and calculations is used to deduce cross section uncertainty. The second dataset is from the aggregate of cross section measurements in the literature for graphite and lead (49 experiments, 288 data points). The dataset is compared to the sum of the XCOM data plus the IAEA photonuclear data. Again, an optimum energy-independent cross section scaling factor is used to deduce the cross section uncertainty. Using the average result from the two datasets, the energy-independent cross section uncertainty estimate is 0.5% (68% confidence) and 0.7% (95% confidence). The potential for energy-dependent errors is discussed. Photon cross section uncertainty is shown to be smaller than the current qualitative 'envelope of uncertainty' of the order of 1-2%, as given by Hubbell (1999 Phys. Med. Biol 44 R1-22).

  19. Sensitivity of modeled ocean heat content to errors in short wave radiation and its attenuation with depth

    Science.gov (United States)

    Shulman, Igor; Gould, Richard W.; Anderson, Stephanie; Sakalaukus, Peter

    2016-05-01

    Short wave radiation (SWR) and its attenuation with depth have a major impact on the vertical distribution of the oceanic water temperature, dynamical processes, and ocean-atmosphere interactions. In numerical modeling of oceanic processes, the SWR usually comes from the atmospheric model predictions, while the short wave attenuation schemes are internally prescribed (estimated) inside the oceanic dynamical model. It has been reported that atmospheric models show a tendency to overestimate the shortwave radiation due to underestimation of predicted low-level clouds. Most existing schemes to specify the attenuation of SWR with depth in numerical models are based on: the Jerlov (1976) water-types classification; climatological estimates of attenuation coefficients or from the biological model predictions of light-absorbing and scattering water constituents. All of the above attenuation schemes are prone to introducing errors in the attenuation of short wave radiation with depth. As a result, we have to deal with two types of errors in the oceanic modeling: those due to the incorrect specification of the magnitude of SWR at the surface (from the atmospheric model), and those due to inaccurate vertical attenuation of SWR (prescribed in the oceanic model). We have developed an approach for estimating errors in the oceanic model heat budget due to errors in surface values of SWR and in its attenuation with depth. Based on this approach, we present examples illustrating sensitivities of the heat budget of the water column to the changes in specification of surface SWR and its attenuation.

  20. Spectral properties of Compton inverse radiation: Application of Compton beams

    Science.gov (United States)

    Bulyak, Eugene; Urakawa, Junji

    2014-05-01

    Compton inverse radiation emitted due to backscattering of laser pulses off the relativistic electrons possesses high spectral density and high energy of photons - in hard x-ray up to gamma-ray energies - because of short wavelength of laser radiation as compared with the classical electromagnetic devices such as undulators. In this report, the possibility of such radiation to monochromatization by means of collimation is studied. Two approaches have been considered for the description of the spectral-angular density of Compton radiation based on the classical field theory and on the quantum electrodynamics. As is shown, both descriptions produce similar total spectra. On the contrary, angular distribution of the radiation is different: the classical approach predicted a more narrow radiation cone. Also proposed and estimated is a method of the 'electronic' monochromatization based on the electronic subtraction of the two images produced by the electron beams with slightly different energies. A 'proof-of-principle' experiment of this method is proposed for the LUXC facility of KEK (Japan).

  1. Predicting Secchi disk depth from average beam attenuation in a deep, ultra-clear lake

    Science.gov (United States)

    Larson, G.L.; Hoffman, R.L.; Hargreaves, B.R.; Collier, R.W.

    2007-01-01

    We addressed potential sources of error in estimating the water clarity of mountain lakes by investigating the use of beam transmissometer measurements to estimate Secchi disk depth. The optical properties Secchi disk depth (SD) and beam transmissometer attenuation (BA) were measured in Crater Lake (Crater Lake National Park, Oregon, USA) at a designated sampling station near the maximum depth of the lake. A standard 20 cm black and white disk was used to measure SD. The transmissometer light source had a nearly monochromatic wavelength of 660 nm and a path length of 25 cm. We created a SD prediction model by regression of the inverse SD of 13 measurements recorded on days when environmental conditions were acceptable for disk deployment with BA averaged over the same depth range as the measured SD. The relationship between inverse SD and averaged BA was significant and the average 95% confidence interval for predicted SD relative to the measured SD was ??1.6 m (range = -4.6 to 5.5 m) or ??5.0%. Eleven additional sample dates tested the accuracy of the predictive model. The average 95% confidence interval for these sample dates was ??0.7 m (range = -3.5 to 3.8 m) or ??2.2%. The 1996-2000 time-series means for measured and predicted SD varied by 0.1 m, and the medians varied by 0.5 m. The time-series mean annual measured and predicted SD's also varied little, with intra-annual differences between measured and predicted mean annual SD ranging from -2.1 to 0.1 m. The results demonstrated that this prediction model reliably estimated Secchi disk depths and can be used to significantly expand optical observations in an environment where the conditions for standardized SD deployments are limited. ?? 2007 Springer Science+Business Media B.V.

  2. Gamma radiation attenuation to study soil particle distribution to forest and sugar cane soils

    International Nuclear Information System (INIS)

    The use of a new soil particle size distribution analysis methodology is presented in connection with the study of particle size distribution in soils covered by natural forest and sugar cane crop cultivated during 16, 30 and 50 years, continuously. The technique is based on the attenuation of a gamma ray beam by a conventional soil/water suspension under sedimentation. Results show a significant difference in clay content for the upper soil layer as a function of sugar cane cultivation. (author). 3 refs., 3 figs

  3. Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis

    Science.gov (United States)

    Dadrich, Monika; Nicolay, Nils H.; Flechsig, Paul; Bickelhaupt, Sebastian; Hoeltgen, Line; Roeder, Falk; Hauser, Kai; Tietz, Alexandra; Jenne, Jürgen; Lopez, Ramon; Roehrich, Manuel; Wirkner, Ute; Lahn, Michael; Huber, Peter E.

    2016-01-01

    ABSTRACT Background: Radiotherapy (RT) is a mainstay for the treatment of lung cancer, but the effective dose is often limited by the development of radiation-induced pneumonitis and pulmonary fibrosis. Transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) play crucial roles in the development of these diseases, but the effects of dual growth factor inhibition on pulmonary fibrosis development remain unclear. Methods: C57BL/6 mice were treated with 20 Gy to the thorax to induce pulmonary fibrosis. PDGF receptor inhibitors SU9518 and SU14816 (imatinib) and TGFβ receptor inhibitor galunisertib were applied individually or in combinations after RT. Lung density and septal fibrosis were measured by high-resolution CT and MRI. Lung histology and gene expression analyses were performed and Osteopontin levels were studied. Results: Treatment with SU9518, SU14816 or galunisertib individually attenuated radiation-induced pulmonary inflammation and fibrosis and decreased radiological and histological signs of lung damage. Combining PDGF and TGFβ inhibitors showed to be feasible and safe in a mouse model, and dual inhibition significantly attenuated radiation-induced lung damage and extended mouse survival compared to blockage of either pathway alone. Gene expression analysis of irradiated lung tissue showed upregulation of PDGF and TGFβ-dependent signaling components by thoracic irradiation, and upregulation patterns show crosstalk between downstream mediators of the PDGF and TGFβ pathways. Conclusion: Combined small-molecule inhibition of PDGF and TGFβ signaling is a safe and effective treatment for radiation-induced pulmonary inflammation and fibrosis in mice and may offer a novel approach for treatment of fibrotic lung diseases in humans. Translational statement: RT is an effective treatment modality for cancer with limitations due to acute and chronic toxicities, where TGFβ and PDGF play a key role. Here, we show that a combined

  4. Diel variability of the beam attenuation and backscattering coefficients in the northwestern Mediterranean Sea (BOUSSOLE site)

    Science.gov (United States)

    Kheireddine, Malika; Antoine, David

    2014-08-01

    The diel variability of the particulate beam attenuation coefficient, cp, and of the particulate backscattering coefficient, bbp, were investigated during five seasonal cycles at an oceanic site in the northwestern Mediterranean Sea, covering contrasting physical and trophic situations. We observed a diel cycle in cp and bbp, related to changes in phytoplankton properties (i.e., size and refractive index) induced by the accumulation of carbon within phytoplankton cells associated with photosynthetic processes, during the winter mixing of the water column, the development of the spring phytoplankton bloom, its decline, and during the summer oligotrophy. The relative amplitude of the cp diel variability was much larger during the spring bloom (20-50%) than during other seasons (10-20%), whereas that of bbp is steadily around 20% and does not show significant seasonal variability. The minimal cp and bbp occurred at sunrise and are synchronized, whereas maximum bbp values are often reached 3-6 h before those for cp (except during bloom conditions), which occur near sunset. These different amplitudes and timing are tentatively explained using Mie computations, which allow discerning the respective roles of changes in the particle size distribution and refractive index. The differences observed here in the diel cycles of cp and bbp show that they cannot be used interchangeably to determine the daily increase of the particle pool. This result has implications on the feasibility to determine net community production from the bbp diel changes, when only bbp is measured in situ or available from ocean color observations.

  5. Successful beam tests for ALICE Transition Radiation Detector

    CERN Multimedia

    2002-01-01

    Another round of beam tests of prototypes for the Transition Radiation Detector (TRD) for ALICE has been completed and there are already some good results. Mass production of the components of the detector will start early next year.   Top view of the setup for the Transition Radiation Detector prototype tests at CERN.On the left, can be seen the full-scale TRD prototype together with four smaller versions. These are busy days for the TRD (Transition Radiation Detector) team of ALICE. Twenty people - mainly from Germany, but also from Russia and Japan - were working hard during the beam tests this autumn at CERN to assess the performance of their detector prototypes. Analysis of the data shows that the TRD can achieve the desired physics goal even for the highest conceivable multiplicities in lead-lead collisions at the LHC. In its final configuration in the ALICE experiment, the TRD will greatly help in identifying high-momentum electrons, which are 'needles in a haystack' that consists mostly of...

  6. Theory for beam-plasma millimeter-wave radiation source experiments

    International Nuclear Information System (INIS)

    This paper reports on theoretical studies for millimeter-wave plasma source experiments. In the device, millimeter-wave radiation is generated in a plasma-filled waveguide driven by counter-streaming electron beams. The beams excite electron plasma waves which couple to produce radiation at twice the plasma frequency. Physics topics relevant to the high electron beam current regime are discussed

  7. Coniferyl aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function.

    Directory of Open Access Journals (Sweden)

    Ye-Ji Jeong

    Full Text Available Radiation enteropathy is a common complication in cancer patients. The aim of this study was to investigate whether radiation-induced intestinal injury could be alleviated by coniferyl aldehyde (CA, an HSF1-inducing agent that increases cellular HSP70 expression. We systemically administered CA to mice with radiation enteropathy following abdominal irradiation (IR to demonstrate the protective effects of CA against radiation-induced gastrointestinal injury. CA clearly alleviated acute radiation-induced intestinal damage, as reflected by the histopathological data and it also attenuated sub-acute enteritis. CA prevented intestinal crypt cell death and protected the microvasculature in the lamina propria during the acute and sub-acute phases of damage. CA induced HSF1 and HSP70 expression in both intestinal epithelial cells and endothelial cells in vitro. Additionally, CA protected against not only the apoptotic cell death of both endothelial and epithelial cells but also the loss of endothelial cell function following IR, indicating that CA has beneficial effects on the intestine. Our results provide novel insight into the effects of CA and suggest its role as a therapeutic candidate for radiation-induced enteropathy due to its ability to promote rapid re-proliferation of the intestinal epithelium by the synergic effects of the inhibition of cell death and the promotion of endothelial cell function.

  8. Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy

    Institute of Scientific and Technical Information of China (English)

    Arunkumar Anandharaj; Senthilkumar Cinghu; Woo-Yoon Park

    2011-01-01

    Survivin, an antiapoptotic protein, is elevated in most malignancies and attributes to radiation resistance in tumors including glioblastoma multiforme. The downregulation of survivin could sensitize glioblastoma ceils to radiation therapy. In this study, we investigated the effect of rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), in attenuating survivin and enhancing the therapeutic efficacy for glioblastoma cells, and elucidated the underlying mechanisms. Here we tested various concentrations of rapamycin (1-8 nM) in combination with radiation dose 4 Gy. Rapamycin effectively modulated the protein kinase B (Akt)/mTOR pathway by inhibiting the phosphorylation of Akt and mTOR proteins, and this inhibition was further enhanced by radiation. The expression level of survivin was decreased in rapamycin pre-treatment glioblastoma ceils followed by radiation; meanwhile, the phosphorylation of H2A histone family member X (H2AX) at serine-139 (γ-H2AX) was increased, p21 protein was also induce on radiation with rapamycin pre-treatment, which enhanced G1 arrest and the accumulation of cells at G0/subG1 phase. Furthermore, the clonogenic cell survival assay revealed a significant dose-dependent decrease in the surviving fraction for all three cell lines pre-treated with rapamycin. Our studies demonstrated that targeting survivin may be an effective approach for radiosensitization of malignant glioblastoma.

  9. Radiation protection considerations along a radioactive ion beam transport line

    Science.gov (United States)

    Sarchiapone, Lucia; Zafiropoulos, Demetre

    2016-09-01

    The goal of the SPES project is to produce accelerated radioactive ion beams for Physics studies at “Laboratori Nazionali di Legnaro” (INFN, Italy). This accelerator complex is scheduled to be built by 2016 for an effective operation in 2017. Radioactive species are produced in a uranium carbide target, by the interaction of 200 μA of protons at 40 MeV. All of the ionized species in the 1+ state come out of the target (ISOL method), and pass through a Wien filter for a first selection and an HMRS (high mass resolution spectrometer). Then they are transported by an electrostatic beam line toward a charge state breeder (where the 1+ to n+ multi-ionization takes place) before selection and reacceleration at the already existing superconducting linac. The work concerning dose evaluations, activation calculation, and radiation protection constraints related to the transport of the radioactive ion beam (RIB) from the target to the mass separator will be described in this paper. The FLUKA code has been used as tool for those calculations needing Monte Carlo simulations, in particular for the evaluation of the dose rate due to the presence of the radioactive beam in the selection/interaction points. The time evolution of a radionuclide inventory can be computed online with FLUKA for arbitrary irradiation profiles and decay times. The activity evolution is analytically evaluated through the implementation of the Bateman equations. Furthermore, the generation and transport of decay radiation (limited to gamma, beta- and beta+ emissions) is possible, referring to a dedicated database of decay emissions using mostly information obtained from NNDC, sometimes supplemented with other data and checked for consistency. When the use of Monte Carlo simulations was not feasible, the Bateman equations, or possible simplifications, have been used directly.

  10. Loss of Matrix Metalloproteinase-13 Attenuates Murine Radiation-Induced Pulmonary Fibrosis

    International Nuclear Information System (INIS)

    Purpose: Pulmonary fibrosis is a disorder of the lungs with limited treatment options. Matrix metalloproteinases (MMPs) constitute a family of proteases that degrade extracellular matrix with roles in fibrosis. Here we studied the role of MMP13 in a radiation-induced lung fibrosis model using a MMP13 knockout mouse. Methods and Materials: We investigated the role of MMP13 in lung fibrosis by investigating the effects of MMP13 deficiency in C57Bl/6 mice after 20-Gy thoracic irradiation (6-MV Linac). The morphologic results in histology were correlated with qualitative and quantitative results of volume computed tomography (VCT), magnetic resonance imaging (MRI), and clinical outcome. Results: We found that MMP13 deficient mice developed less pulmonary fibrosis than their wildtype counterparts, showed attenuated acute pulmonary inflammation (days after irradiation), and a reduction of inflammation during the later fibrogenic phase (5-6 months after irradiation). The reduced fibrosis in MMP13 deficient mice was evident in histology with reduced thickening of alveolar septi and reduced remodeling of the lung architecture in good correlation with reduced features of lung fibrosis in qualitative and quantitative VCT and MRI studies. The partial resistance of MMP13-deficient mice to fibrosis was associated with a tendency towards a prolonged mouse survival. Conclusions: Our data indicate that MMP13 has a role in the development of radiation-induced pulmonary fibrosis. Further, our findings suggest that MMP13 constitutes a potential drug target to attenuate radiation-induced lung fibrosis.

  11. Radiation produced by the modulated electron beam of a free electron laser

    OpenAIRE

    Neighbours, John Robert; Maruyama, Xavier K.; Buskirk, Fred Ramon

    1986-01-01

    The electron beam in a free electron laser (FEL) becomes axially modulated at the optical wave length of the FEL radiation. This electron beam passed through a gas may produce intense Cerenkov radiation. The effects of the radial and axial dimension of the electron bunches on the radiation are explored

  12. Experimental realization of fluence field modulated CT using digital beam attenuation

    International Nuclear Information System (INIS)

    Tailoring CT scan acquisition parameters to individual patients is a topic of much research in the CT imaging community. It is now common place to find automatically adjusted tube current options for modern CT scanners. In addition, the use of beam shaping filters, commonly called bowtie filters, is available on most CT systems and allows for different body regions to receive different incident x-ray fluence distributions. However, no method currently exists which allows for the form of the incident x-ray fluence distribution to change as a function of the view angle. This study represents the first experimental realization of fluence field modulated CT (FFMCT) for a c-arm geometry CT scan. X-ray fluence modulation is accomplished using a digital beam attenuator (DBA). The device is composed of ten iron wedge pairs that modulate the thickness of iron, the x-rays must traverse before reaching a patient. Using this device, experimental data was taken using a Siemens Zeego c-arm scanner. Scans were performed on a cylindrical polyethylene phantom and on two different sections of an anthropomorphic phantom. The DBA was used to equalize the x-ray fluence striking the detector for each scan. Non DBA, or ‘flat field’ scans were also acquired of the same phantom objects for comparison. In addition, a scan was performed in which the DBA was used to enable volume of interest (VOI) imaging. In VOI, only a small sub-volume within a patient receives full dose and the rest of the patient receives a much lower dose. Data corrections unique to using a piece-wise constant modulator were also developed. The feasibility of FFMCT implemented using a DBA device has been demonstrated. Initial results suggest dose reductions of up to 3.6 times relative to ‘flat field’ CT. In addition to dose reduction, the DBA enables a large improvement in image noise uniformity and the ability to provide regionally enhanced signal to noise using VOI imaging techniques. The results presented in

  13. Experimental realization of fluence field modulated CT using digital beam attenuation

    Science.gov (United States)

    Szczykutowicz, T. P.; Mistretta, C. A.

    2014-03-01

    Tailoring CT scan acquisition parameters to individual patients is a topic of much research in the CT imaging community. It is now common place to find automatically adjusted tube current options for modern CT scanners. In addition, the use of beam shaping filters, commonly called bowtie filters, is available on most CT systems and allows for different body regions to receive different incident x-ray fluence distributions. However, no method currently exists which allows for the form of the incident x-ray fluence distribution to change as a function of the view angle. This study represents the first experimental realization of fluence field modulated CT (FFMCT) for a c-arm geometry CT scan. X-ray fluence modulation is accomplished using a digital beam attenuator (DBA). The device is composed of ten iron wedge pairs that modulate the thickness of iron, the x-rays must traverse before reaching a patient. Using this device, experimental data was taken using a Siemens Zeego c-arm scanner. Scans were performed on a cylindrical polyethylene phantom and on two different sections of an anthropomorphic phantom. The DBA was used to equalize the x-ray fluence striking the detector for each scan. Non DBA, or ‘flat field’ scans were also acquired of the same phantom objects for comparison. In addition, a scan was performed in which the DBA was used to enable volume of interest (VOI) imaging. In VOI, only a small sub-volume within a patient receives full dose and the rest of the patient receives a much lower dose. Data corrections unique to using a piece-wise constant modulator were also developed. The feasibility of FFMCT implemented using a DBA device has been demonstrated. Initial results suggest dose reductions of up to 3.6 times relative to ‘flat field’ CT. In addition to dose reduction, the DBA enables a large improvement in image noise uniformity and the ability to provide regionally enhanced signal to noise using VOI imaging techniques. The results presented in

  14. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Centre, Department of Surgery (Netherlands); Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Kemerink, Gerrit J., E-mail: gerrit.kemerink@mumc.nl; Jeukens, Cécile R. L. P. N., E-mail: cecile.jeukens@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands)

    2015-02-15

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight.

  15. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    Science.gov (United States)

    Povoli, M.; Alagoz, E.; Bravin, A.; Cornelius, I.; Bräuer-Krisch, E.; Fournier, P.; Hansen, T. E.; Kok, A.; Lerch, M.; Monakhov, E.; Morse, J.; Petasecca, M.; Requardt, H.; Rosenfeld, A. B.; Röhrich, D.; Sandaker, H.; Salomé, M.; Stugu, B.

    2015-11-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper.

  16. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    International Nuclear Information System (INIS)

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper

  17. Characterization of barite and crystal glass as attenuators in X-ray and gamma radiation shieldings

    International Nuclear Information System (INIS)

    Aiming to determine the barium sulphate (BaSO4) ore and crystal glass attenuation features, both utilized as shieldings against ionizing X and gamma radiations in radiographic installations, a study of attenuation using barite plaster and barite concrete was carried out, which are used, respectively, on wall coverings and in block buildings. The crystal glass is utilized in screens and in windows. To do so, ten plates of barite plaster and three of barite concrete with 900 cm2 and with an average thickness ranging from 1 to 5 cm, and three plates of crystal glass with 323 cm2 and with thicknesses of 1, 2 and 4 cm were analyzed. The samples were irradiated with X-rays with potentials of 60, 80, 110 and 150 kilovolts, and also with 60Co gamma rays. Curves of attenuation were obtained for barite plaster and barite concrete (mGy/mA.min) and (mGy/h), both at 1 meter, as a function of thickness and curve of transmission through barite plaster and barite concrete as a function of the thickness. The equivalent thicknesses of half and tenth value layers for barite plaster, barite concrete and crystal glass for all X-Ray energies were also determined. (author)

  18. Radiation Safety System for SPIDER Neutral Beam Accelerator

    Science.gov (United States)

    Sandri, S.; Coniglio, A.; D'Arienzo, M.; Poggi, C.

    2011-12-01

    SPIDER (Source for Production of Ion of Deuterium Extracted from RF Plasma only) and MITICA (Megavolt ITER Injector Concept Advanced) are the ITER neutral beam injector (NBI) testing facilities of the PRIMA (Padova Research Injector Megavolt Accelerated) Center. Both injectors accelerate negative deuterium ions with a maximum energy of 1 MeV for MITICA and 100 keV for SPIDER with a maximum beam current of 40 A for both experiments. The SPIDER facility is classified in Italy as a particle accelerator. At present, the design of the radiation safety system for the facility has been completed and the relevant reports have been presented to the Italian regulatory authorities. Before SPIDER can operate, approval must be obtained from the Italian Regulatory Authority Board (IRAB) following a detailed licensing process. In the present work, the main project information and criteria for the SPIDER injector source are reported together with the analysis of hypothetical accidental situations and safety issues considerations. Neutron and photon nuclear analysis is presented, along with special shielding solutions designed to meet Italian regulatory dose limits. The contribution of activated corrosion products (ACP) to external exposure of workers has also been assessed. Nuclear analysis indicates that the photon contribution to worker external exposure is negligible, and the neutron dose can be considered by far the main radiation protection issue. Our results confirm that the injector has no important radiological impact on the population living around the facility.

  19. Radiation Safety System for SPIDER Neutral Beam Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Sandri, S.; Poggi, C. [ENEA, Radiation Protection Institute, IRP-FUAC, Frascati (Italy); Coniglio, A. [Medical Physics Department, S. Giovanni Calibita Hospital, Fatebenefratelli, Isola Tiberina, Roma (Italy); D' Arienzo, M. [ENEA, Ionizing Radiation Metrology National Institute, METR, Casaccia, Rome (Italy)

    2011-12-13

    SPIDER (Source for Production of Ion of Deuterium Extracted from RF Plasma only) and MITICA (Megavolt ITER Injector Concept Advanced) are the ITER neutral beam injector (NBI) testing facilities of the PRIMA (Padova Research Injector Megavolt Accelerated) Center. Both injectors accelerate negative deuterium ions with a maximum energy of 1 MeV for MITICA and 100 keV for SPIDER with a maximum beam current of 40 A for both experiments. The SPIDER facility is classified in Italy as a particle accelerator. At present, the design of the radiation safety system for the facility has been completed and the relevant reports have been presented to the Italian regulatory authorities. Before SPIDER can operate, approval must be obtained from the Italian Regulatory Authority Board (IRAB) following a detailed licensing process. In the present work, the main project information and criteria for the SPIDER injector source are reported together with the analysis of hypothetical accidental situations and safety issues considerations. Neutron and photon nuclear analysis is presented, along with special shielding solutions designed to meet Italian regulatory dose limits. The contribution of activated corrosion products (ACP) to external exposure of workers has also been assessed. Nuclear analysis indicates that the photon contribution to worker external exposure is negligible, and the neutron dose can be considered by far the main radiation protection issue. Our results confirm that the injector has no important radiological impact on the population living around the facility.

  20. A new non intercepting beam size diagnostics using diffraction radiation from a Slit

    Energy Technology Data Exchange (ETDEWEB)

    Castellano, M. [Istituto Nazionale di Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati

    1996-09-01

    A new non interpreting beam size diagnostic for high charge electron beams is presented. This diagnostics is based on the analysis of the angular distribution of the `diffracted` transition radiation emitted by the beam when crossing a slit cut in metallic foil. It allows a resolution better then the radiation transverse formation zone. Numerical results based on the parameters of the TTF FEL beam are given as example.

  1. Effective radiation attenuation calibration for breast density: compression thickness influences and correction

    Directory of Open Access Journals (Sweden)

    Thomas Jerry A

    2010-11-01

    Full Text Available Abstract Background Calibrating mammograms to produce a standardized breast density measurement for breast cancer risk analysis requires an accurate spatial measure of the compressed breast thickness. Thickness inaccuracies due to the nominal system readout value and compression paddle orientation induce unacceptable errors in the calibration. Method A thickness correction was developed and evaluated using a fully specified two-component surrogate breast model. A previously developed calibration approach based on effective radiation attenuation coefficient measurements was used in the analysis. Water and oil were used to construct phantoms to replicate the deformable properties of the breast. Phantoms consisting of measured proportions of water and oil were used to estimate calibration errors without correction, evaluate the thickness correction, and investigate the reproducibility of the various calibration representations under compression thickness variations. Results The average thickness uncertainty due to compression paddle warp was characterized to within 0.5 mm. The relative calibration error was reduced to 7% from 48-68% with the correction. The normalized effective radiation attenuation coefficient (planar representation was reproducible under intra-sample compression thickness variations compared with calibrated volume measures. Conclusion Incorporating this thickness correction into the rigid breast tissue equivalent calibration method should improve the calibration accuracy of mammograms for risk assessments using the reproducible planar calibration measure.

  2. Lateral vibration attenuation of a beam with circular cross-section by a support with integrated piezoelectric transducers shunted to negative capacitances

    Science.gov (United States)

    Götz, Benedict; Schaeffner, Maximilian; Platz, Roland; Melz, Tobias

    2016-09-01

    Undesired vibration may occur in lightweight structures due to excitation and low damping. For the purpose of lateral vibration attenuation in beam structures, piezoelectric transducers shunted to negative capacitances can be an appropriate measure. In this paper, a new concept for lateral vibration attenuation by integrated piezoelectric stack transducers in the elastic support of a beam with circular cross-section is presented. In the piezoelastic support, bending of the beam in an arbitrary direction is transformed into a significant axial deformation of three stack transducers and, thus, the beam’s surface may remain free from transducers. For multimodal vibration attenuation, each piezoelectric transducer is shunted to a negative capacitance. It is shown by numerical simulation and experiment that the concept of an elastic beam support with integrated shunted piezoelectric stack transducers is capable of reducing the lateral vibration of the beam in an arbitrary direction.

  3. Radiative damping and electron beam dynamics in plasma-based accelerators.

    Science.gov (United States)

    Michel, P; Schroeder, C B; Shadwick, B A; Esarey, E; Leemans, W P

    2006-08-01

    The effects of radiation reaction on electron beam dynamics are studied in the context of plasma-based accelerators. Electrons accelerated in a plasma channel undergo transverse betatron oscillations due to strong focusing forces. These oscillations lead to emission by the electrons of synchrotron radiation, with a corresponding energy loss that affects the beam properties. An analytical model for the single particle orbits and beam moments including the classical radiation reaction force is derived and compared to the results of a particle transport code. Since the betatron amplitude depends on the initial transverse position of the electron, the resulting radiation can increase the relative energy spread of the beam to significant levels (e.g., several percent). This effect can be diminished by matching the beam into the channel, which could require micron sized beam radii for typical values of the beam emittance and plasma density.

  4. Radiative damping and electron beam dynamics in plasma-based accelerators

    Science.gov (United States)

    Michel, P.; Schroeder, C. B.; Shadwick, B. A.; Esarey, E.; Leemans, W. P.

    2006-08-01

    The effects of radiation reaction on electron beam dynamics are studied in the context of plasma-based accelerators. Electrons accelerated in a plasma channel undergo transverse betatron oscillations due to strong focusing forces. These oscillations lead to emission by the electrons of synchrotron radiation, with a corresponding energy loss that affects the beam properties. An analytical model for the single particle orbits and beam moments including the classical radiation reaction force is derived and compared to the results of a particle transport code. Since the betatron amplitude depends on the initial transverse position of the electron, the resulting radiation can increase the relative energy spread of the beam to significant levels (e.g., several percent). This effect can be diminished by matching the beam into the channel, which could require micron sized beam radii for typical values of the beam emittance and plasma density.

  5. Equalization of Medipix2 imaging detector energy thresholds using measurement of polychromatic X-ray beam attenuation

    International Nuclear Information System (INIS)

    The single photon counting pixel detector Medipix2 is a powerful tool for energy resolved X-ray imaging. It allows the energies of incoming X-rays to be discriminated by setting an energy threshold common to all pixels. As the parameters of individual pixels vary, each pixel further contains a 3-bit digital-to-analogue converter (DAC) adjustment. Values of these DACs are traditionally determined by finding the noise floor in each pixel. Our approach is based on a polychromatic X-ray beam attenuation measurement. An attenuation curve is measured using varying thickness of aluminium foil. The attenuation curve is fitted in each pixel with a function calculating the detected signal. Free parameters of the fit are the beam intensity and the energy threshold. The measurement is done twice, with the threshold adjustment set to minimum resp. maximum value in all pixels. The result is a calibration of the adjustment DACs, allowing the value of the adjustment DAC in each pixel to be found such that the dispersion of energy thresholds between pixels is minimized. It is a fast and simple to use method that does not require modification of the imaging setup. It will be shown that it reduces the dispersion of threshold values by up to 40% compared to the noise-floor based technique of equalization.

  6. Beam stabilization in the two-dimensional nonlinear Schrodinger equation with an attractive potential by beam splitting and radiation

    DEFF Research Database (Denmark)

    leMesurier, B.J.; Christiansen, Peter Leth; Gaididei, Yuri Borisovich;

    2004-01-01

    and can lead to a stable oscillating beam. This is observed to involve a splitting of the beam into an inner part that is oscillatory and of subcritical power and an outer dispersing part. An analysis is given in terms of the rate competition between the linear and nonlinear focusing effects, radiation...

  7. The Beaming Pattern of Doppler Boosted Thermal Annihilation Radiation: Application to MeV Blazars

    OpenAIRE

    Skibo, J. G.; Dermer, C. D.; Schlickeiser, R.

    1997-01-01

    The beaming pattern of thermal annihilation radiation is broader than the beaming pattern produced by isotropic nonthermal electrons and positrons in the jets of radio-emitting active galactic nuclei which Compton scatter photons from an external isotropic radiation field. Thus blueshifted thermal annihilation radiation can provide the dominant contribution to the high-energy radiation spectrum at observing angles theta > 1/Gamma, where Gamma is the bulk Lorentz factor of the outflowing plasm...

  8. Impact of Atmospheric Attenuations Time Resolutions in Solar Radiation Derived from Satellite Imagery

    Science.gov (United States)

    Cony, Marco; Liria, Juan; Weisenberg, Ralf; Serrano, Enrique

    2014-05-01

    Accurate knowledge of solar irradiance components at the earth surface is of highly interest in many scientific and technology branches concerning meteorology, climate, agriculture and solar energy applications. In the specific case of solar energy systems the solar resource analysis with accuracy is a first step in every project since it is a required data for design, power output estimations, systems simulations and risk assessments. Solar radiation measurement availability is increasing both in spatial density and in historical archiving. However, it is still quite limited and most of the situations cannot make use of a long term ground database of high quality since solar irradiance is not generally measured where users need data. Satellite-derived solar radiation estimations are a powerful and valuable tool for solar resource assessment studies that have achieved a relatively high maturity due to years of developments and improvements. However, several sources of uncertainty are still present in satellite-derived methods. In particular, the strong influence of atmospheric attenuation information as input to the method is one of the main topics of improvement. Since solar radiation attenuation by atmospheric aerosols, and water vapor in a second place, is, after clouds, the second most important factor determining solar radiation, and particularly direct normal irradiance, the accurate knowledge of aerosol optical depth and water vapor content is relevant in the final output of satellite-derived methods. This present work, two different datasets we are used for extract atmospheric attenuation information. On the one hand the monthly mean values of the Linke turbidity factor from Meteotest database, which are twelve unique values of the Linke turbidity worldwide with a spatial resolution of 1/12º. On the other hand, daily values of AOD (Aerosol Optical Depth) at 550 nm, Angstrom alpha exponent and water vapor column were taken from a gridded database that

  9. Radiation sterilization of fluoroquinolones in solid state: Investigation of effect of gamma radiation and electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Babita K., E-mail: singhbab2001@rediffmail.co [Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033 (India); Central Forensic Science Laboratory, Ramanthapur, Hyderabad 500013 (India); Parwate, Dilip V. [Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033 (India); Dassarma, Indrani B. [Jhulelal Institute of Technology, Nagpur (India); Shukla, Sudhir K. [Central Forensic Science Laboratory, Ramanthapur, Hyderabad 500013 (India)

    2010-09-15

    The effect of gamma radiation from {sup 60}Co source and 2 MeV electron beam was studied on two fluoroquinolone antibiotics viz norfloxacin and gatifloxacin in the solid state. The changes in reflectance spectrum, yellowness index, vibrational characteristics, thermal behavior, UV spectrum, chemical potency (HPLC) and microbiological potency were investigated. ESR measurement gave the number of free radical species formed and their population. The nature of final radiolytic impurities was assessed by studying the HPLC impurity profile. Both norfloxacin and gatifloxacin were observed to be radiation resistant, and did not show significant changes in their physico-chemical properties. They could be radiation sterilized at a dose of 25 kGy.

  10. Ambient ultraviolet radiation induces protective responses in soybean but does not attenuate indirect defense

    Energy Technology Data Exchange (ETDEWEB)

    Winter, Thorsten R. [Department of Botany II, Julius-von-Sachs Institute for Biosciences, University of Wuerzburg, Julius-von-Sachs-Platz 3, 97082 Wuerzburg (Germany); Rostas, Michael [Department of Botany II, Julius-von-Sachs Institute for Biosciences, University of Wuerzburg, Julius-von-Sachs-Platz 3, 97082 Wuerzburg (Germany)], E-mail: rostas@botanik.uni-wuerzburg.de

    2008-09-15

    We investigated the effects of ambient ultraviolet (UV) radiation on (i) the performance and chemistry of soybean plants, (ii) the performance of Spodoptera frugiperda and (iii) the foraging behavior of the herbivore's natural enemy Cotesia marginiventris which exploits herbivore-induced plant volatiles (VOC) for host location. The accumulation of protective phenolics was faster in plants receiving ambient UV than in controls exposed to sun light lacking UV. Accordingly, isorhamnetin- and quercetin-based flavonoids were increased in UV exposed plants. No UV effects were found on the performance and feeding behavior of S. frugiperda. Herbivore-damaged plants emitted the same VOC when grown under ambient or attenuated UV for 5, 10 or 30 days. Consequently, C. marginiventris was attracted but did not discriminate between exposed and unexposed soybeans. In summary, ambient UV radiation affected soybean morphology and physiology but did not destabilize interactions between trophic levels. - Ambient ultraviolet radiation does not alter induced VOC emission in soybean and thus host location of the parasitoid Cotesia marginiventris remains effective.

  11. Toxicity attenuation optimization of crotalic venom by gamma radiation and studies of its immunogenic properties

    International Nuclear Information System (INIS)

    Literature data show that 2.0 kGy dose of gamma radiation, generated by 60 source, reduces the toxic activity of Crotalus durissus terrificus venom, without altering its immunogenic capacity. When crotoxin, main toxin from crotalic venom, was irradiated with the same dose, toxicity was also reduced and the immunogenicity was maintained. This fact was attributed to aggregates (compounds with high molecular weight generated during irradiation), that showed no toxicity but were able to induce the antibodies formation against native venom. Crotalus durissus terrificus venom was irradiated with 2.0, 3.0, 5.0 and 10.0 kGy doses and submitted to molecular exclusion chromatography, in order to find an efficient dose that produces large amounts of non toxic but still immunogenic aggregates. After being isolated, the products of irradiation were evaluated for the amount produced, molecular alteration, and toxic and immunogenic activities. These parameters were also analyzed for the whole venom irradiated. The results from different doses irradiated venom were compared with native one, and 2.0 kGy dose was confirmed to be the most efficient in the association of toxicity attenuation with maintenance of immunogenicity of the crotalic venom, while other doses, in spite of being efficient in the toxicity attenuation, they were not able to keep the immunogenicity property. So, the dose of 2.0 kGy could be used to immunize animals in order to improve anticrotalic sera production. (author)

  12. Maximum entropy inference of seabed attenuation parameters using ship radiated broadband noise.

    Science.gov (United States)

    Knobles, D P

    2015-12-01

    The received acoustic field generated by a single passage of a research vessel on the New Jersey continental shelf is employed to infer probability distributions for the parameter values representing the frequency dependence of the seabed attenuation and the source levels of the ship. The statistical inference approach employed in the analysis is a maximum entropy methodology. The average value of the error function, needed to uniquely specify a conditional posterior probability distribution, is estimated with data samples from time periods in which the ship-receiver geometry is dominated by either the stern or bow aspect. The existence of ambiguities between the source levels and the environmental parameter values motivates an attempt to partially decouple these parameter values. The main result is the demonstration that parameter values for the attenuation (α and the frequency exponent), the sediment sound speed, and the source levels can be resolved through a model space reduction technique. The results of this multi-step statistical inference developed for ship radiated noise is then tested by processing towed source data over the same bandwidth and source track to estimate continuous wave source levels that were measured independently with a reference hydrophone on the tow body. PMID:26723313

  13. The effect of a metal hip prosthesis on the radiation dose in therapeutic photon beam irradiations

    International Nuclear Information System (INIS)

    Prostate and cervical cancer patients are often treated with external X-ray beams of bi-lateral incidence. Such treatment may incur some dose effect that cannot be predicted precisely in commercial treatment planning systems (TPS) for patients having undergone total hip replacement. This study performs a Monte Carlo (MC) simulation and an analytical calculation (convolution superposition algorithm which is implemented in ADAC TPS) of a 6 MV, 5x5 cm2 X-ray beam incident into water with the existence of hip prosthesis, e.g. Ti6Al4V and CoCrMo alloy. The results indicate that ADAC TPS cannot precisely account for the scatter and backscatter radiation that a metal hip prosthesis causes. For percent depth dose (PDD) curves, the maximum underdosage of ADAC TPS up to 5 mm above the interface between dense material and water is 5%, 20% and 27% for PDDBone, PDDTi and PDDCo, respectively. The dose re-buildup, which occurs behind the hip region, becomes more and more obvious for denser medium existed in water. Increasing inhomogeneity also enhances the underdosage of ADAC for greater depth (>10 cm), as the figures of nearly 2% in PDDBone, PDDTi and 4-5% in PDDCo reveal. Overestimating the attenuated power of high-density non-water material in ADAC TPS causes this underdosage. For dose profiles, no significant differences were found in ProfileBone at any depth. ProfileTi reveals that MC slightly exceeds ADAC at off-axis position 1.0-2.0 cm. ProfileCo reveals this more obviously. This finding means that scatter radiation from these denser materials is significant and cannot be predicted precisely in ADAC

  14. Study of Synchrotron Radiation for the Electron Beam Polarimeter for the MEIC

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-06

    This is a look at the synchrotron radiation coming from the chicane in the electron beam line for the MEIC design. The power density on the beam pipe as well as transmission through the beam pipe is studied. The optics design is version 12.

  15. Statistical uncertainty in educational experiment on the attenuation of gamma radiation

    CERN Document Server

    Pilakouta, Mirofora

    2011-01-01

    Due to time and financial restrictions in an educational laboratory, we are making compromises, using experimental setups in which limitations and uncertainties are important. In these cases we should pay particular attention to the role of different factors that affect our experiment, in order to achieve the best possible educational outcome and to avoid misconceptions. In this paper problems related to the use of very low activity source 60Co in the experiment of measuring the linear attenuation coefficient of gamma rays through matter, will be presented. The role of background radiation in measurements and in the relative statistical uncertainty as well as the role of statistical uncertainty in the choice of representative measurements is discussed. Moreover students' difficulties and misconceptions related mainly to the statistical uncertainty and its connection to measurements overlapping are recorded. An explanation for the possible reasons of these misunderstandings is attempted in order to improve the...

  16. Design, construction and characterization of special ionization chambers for X radiation beams monitoring

    International Nuclear Information System (INIS)

    X radiation equipment may show fluctuations in the radiation beam intensity, as they are connected to the power net. These intensity variations can, in turn, modify the air kerma rate produced by this radiation beam. In a calibration laboratory, where radiation detectors (from clinics and hospital services) are calibrated, variations in the radiation beam intensity may cause an error in the absorbed dose determination. The monitor ionization chambers are used to verify the radiation beam intensity constancy, and to provide a correction for possible fluctuations. In this work, monitor ionization chambers for X radiation beams were designed, assembled and characterized. The developed ionization chambers have an innovative design, ring-shaped, with aluminium or graphite electrodes. These ring-shaped ionization chambers have the advantage of not interfering in the direct radiation beams. A double-volume ionization chamber with graphite electrodes was also developed. This ionization chamber is similar to the commercial monitor ionization chamber used in the Calibration Laboratory of the Instituto de Pesquisas Energeticas e Nucleares. All developed ionization chambers were tested in several standardized radiation beams and their performances were compared with those of commercial ionization chambers. The results show that two of the four ionization chambers developed showed performance comparable to that of the commercial ionization chambers tested. Besides presenting good results, the ionization chambers were designed and manufactured using low cost materials, which are easily found on the Brazilian market. (author)

  17. Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes.

    Directory of Open Access Journals (Sweden)

    Gary P Dillon

    Full Text Available BACKGROUND: Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising radiation that truncates their migration in the lungs. However, the underlying molecular mechanisms responsible for the altered phenotype of the irradiated parasite that primes for protection have yet to be identified. METHODOLOGY/PRINCIPAL FINDINGS: We have used a custom microarray comprising probes derived from lung-stage parasites to compare patterns of gene expression in schistosomula derived from normal and irradiated cercariae. These were transformed in vitro and cultured for four, seven, and ten days to correspond in development to the priming parasites, before RNA extraction. At these late times after the radiation insult, transcript suppression was the principal feature of the irradiated larvae. Individual gene analysis revealed that only seven were significantly down-regulated in the irradiated versus normal larvae at the three time-points; notably, four of the protein products are present in the tegument or associated with its membranes, perhaps indicating a perturbed function. Grouping of transcripts using Gene Ontology (GO and subsequent Gene Set Enrichment Analysis (GSEA proved more informative in teasing out subtle differences. Deficiencies in signalling pathways involving G-protein-coupled receptors suggest the parasite is less able to sense its environment. Reduction of cytoskeleton transcripts could indicate compromised structure which, coupled with a paucity of neuroreceptor transcripts, may mean the parasite is also unable to respond correctly to external stimuli. CONCLUSIONS/SIGNIFICANCE: The transcriptional differences observed are concordant with the known extended transit of attenuated parasites through skin-draining lymph nodes and the lungs: prolonged priming of the immune system by the parasite, rather than over-expression of novel antigens, could thus

  18. STUDY OF THE BEAM INDUCED RADIATION IN THE CMS DETECTOR AT THE LARGE HADRON COLLIDER

    CERN Document Server

    Singh, Amandeep P; Mokhov, Nikolai; Beri, Suman Bala

    2009-01-01

    point, are most vulnerable to beam-induced radiation. We have recently carried out extensive monte carlo simulation studies using MARS program to estimate particle fluxes and radiation dose in the CMS silicon pixel and strip trackers from proton-proton collisions at $\\sqrt s $=14 TeV and from machine induced background such as beam-gas interactions and beam-halo. We will present results on radiation dose, particle fluxes and spectra from these studies and discuss implications for radiation damage and performance of the CMS silicon tracker detec...

  19. Imaging and characterization of primary and secondary radiation in ion beam therapy

    Science.gov (United States)

    Granja, Carlos; Martisikova, Maria; Jakubek, Jan; Opalka, Lukas; Gwosch, Klaus

    2016-07-01

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  20. Variable laser attenuator

    Science.gov (United States)

    Foltyn, Stephen R.

    1988-01-01

    The disclosure relates to low loss, high power variable attenuators comprng one or more transmissive and/or reflective multilayer dielectric filters. The attenuator is particularly suitable to use with unpolarized lasers such as excimer lasers. Beam attenuation is a function of beam polarization and the angle of incidence between the beam and the filter and is controlled by adjusting the angle of incidence the beam makes to the filter or filters. Filters are selected in accordance with beam wavelength.

  1. Wheat Germ Oil Attenuates Gamma Radiation- Induced Skeletal Muscles Damage in Rats

    International Nuclear Information System (INIS)

    Muscular strength is important in sport as well as in daily activities. Exposure to ionizing radiation is thought to increase oxidative stress and damage muscle tissue. Wheat germ oil is a natural unrefined vegetable oil. It is an excellent source of vitamin E, octacosanol, linoleic and linolenic essential fatty acids, which may be beneficial in neutralizing the free oxygen radicals. The present study was designed to investigate the efficacy of wheat germ oil, on radiation-induced oxidative damage in rats skeletal muscle. Wheat germ oil was supplemented orally via gavages to rats at a dose of 54 mg/ kg body weight/day for 14 successive days pre- and 7 post-exposure to 5 Gy (one shot dose) of whole body gamma irradiation. Animals were sacrificed 7, 14 and 21 days post radiation exposure. The results revealed that whole body gamma-irradiation of rats induces oxidative stress in skeletal muscles obvious by significant elevation in the level of thiobarbituric acid reactive substances (TBARS) associated with significant decreases in the content of reduced glutathione (GSE1), as well as decreases in superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities. Irradiated rats showed, also, significant decreases in creatine phosphokinase (CPK), glutamate dehydrogenase (GDH) and glucose-6-phosphate dehydrogenase (G-6-PD) activities. Furthermore, total iron, total copper and total calcium levels were significantly increased in skeletal muscles of irradiated rats group compared to control group. Wheat germ oil treated-irradiated rats showed significantly less sever damage and remarkable improvement in all the measured parameters, compared to irradiated rats. It could be concluded that wheat germ oil by attenuating radiation induced oxidative stress might play a role in maintaining skeletal muscle integrity

  2. Generation of high-power electromagnetic radiation by a beam-driven plasma antenna

    Science.gov (United States)

    Annenkov, V. V.; Volchok, E. P.; Timofeev, I. V.

    2016-04-01

    In this paper we study how efficiently electromagnetic radiation can be generated by a relativistic electron beam with a gigawatt power level during its injection into a thin magnetized plasma. It is shown that, if the transverse beam and plasma size is compared with the radiation wavelength and the plasma density is modulated along the magnetic field, such a beam-plasma system can radiate electromagnetic waves via the antenna mechanism. We propose a theoretical model describing generation of electromagnetic waves by this plasma antenna and calculate its main radiation characteristics. In the two-dimensional case theoretical predictions on the radiation efficiency are shown to be confirmed by the results of particle-in-cell simulations, and the three-dimensional variant of this theory is used to estimate the peak power of sub-terahertz radiation that can be achieved in beam-plasma experiments in mirror traps.

  3. Calculation of radiation attenuation coefficients in Portland cements mixed with silica fume, blast furnace slag and natural zeolite

    International Nuclear Information System (INIS)

    This paper presents the radiation attenuation coefficients expressed as mass attenuation coefficients for Portland cement, zeolite, blast furnace slag, silica fume and their mixed types in function of the Photon energy over the energy range of 1 keV to 2 MeV. It was observed that different percentages of constituents in cement and cement mixed with different additives such as zeolite, silica fume and blast furnace slag, lead to significant variations in total mass attenuation coefficients. The elemental compositions of samples were analyzed using a wavelength dispersive XRF spectrometer. The calculated values of total mass attenuation coefficients were discussed on the basis of different percentages of constituents of cement and cement mixed with different additives

  4. Helium-tight Laser Beam Welding of Aluminum with Brillant Laser Beam Radiation

    Science.gov (United States)

    Heinen, Paul; Wu, Hao; Olowinsky, Alexander; Gillner, Arnold

    The substitution of steel as base metal for casings and packaging applications has increased during the last years. Especially aluminum with advantages in weight and machining effort has become a versatile solution for applications in fine mechanics (e.g. sensor housings) and automotive applications. Joining of aluminum components is more critical due to possible crack formation in the joining seam and uneven seam geometry. With the high intensity of brillant laser beam sources the specific challenges of aluminum welding can be overcome. Due to its hydrogen affinity and high degree of reflection for laser radiation at a wavelength of 1 μm (95%) aluminum needs to be welded with proper shielding gas support and high beam quality in order to avoid seam defects. Cracks and pores can lead to non-sufficient tightness for sensor applications and early failure. Housing components have been joined to form a functioning unit in order to seal electrical or measuring components, which are helium-tight for these applications.

  5. Effect of ocular implants of different materials on the dosimetry of external beam radiation therapy

    International Nuclear Information System (INIS)

    Purpose: To study the attenuation and scattering effects of ocular implants, made from different materials, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams used in orbital radiotherapy. Methods and Materials: Central axis depth-dose measurements were performed in a polystyrene phantom with embedded spherical ocular implants using film dosimetry of a 6 MV photon beam and electron beams of 6, 9, and 12 MeV energy. The isodose distributions were also calculated by a computerized treatment planning system using computerized tomography (CT) scans of a polystyrene phantom that had silicone, acrylic, and hydroxyapatite ocular implants placed into it. Results: Electron beam dose distributions display distortions both on the measured and calculated data. This effect is most accentuated for the hydroxyapatite implants, for which the transmissions through ocular implants are on the order of 93% for the 6 MV photon beam, and range from 60% for 6 MeV electrons to 90% for 12 MeV electrons. Conclusion: We studied the effect of ocular implants of various materials, embedded in a polystyrene phantom, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams. Our investigations show that while 6 MV photons experience only a few percent attenuation, lower energy electron beam with 60% transmission is not a suitable choice of treating tumors behind the ocular implants

  6. Silibinin attenuates ionizing radiation-induced pro-angiogenic response and EMT in prostate cancer cells

    International Nuclear Information System (INIS)

    Graphical abstract: Potential model showing mechanism of silibinin-mediated attenuation of IR-induced angiogenic phenotype and EMT in tumor cells. Silibinin counters radiation induced invasive and migratory phenotype of cancer cells by down-regulating mitogenic pathways activated by IR, leading to inhibition of molecules including VEGF, iNOS, MMPs and N-cadherin. Silibinin also reverses IR mediated E-cadherin down-regulation, inhibiting EMT in tumor cells. Silibinin also radiosensitizes endothelial cells, reduces capillary tube formation by targeting various pro-angiogenic molecules. Further, silibinin may inhibit autocrine and paracrine signaling between tumor and endothelial cells by decreasing the levels of VEGF and other signaling molecules activated in response to IR. - Highlights: • Silibinin radiosensitizes endothelial cells. • Silibinin targets ionization radiation (IR)-induced EMT in PCa cells. • Silibinin is in phase II clinical trial in PCa patients, hence clinically relevant. - Abstract: Radiotherapy of is well established and frequently utilized in prostate cancer (PCa) patients. However, recurrence following therapy and distant metastases are commonly encountered problems. Previous studies underline that, in addition to its therapeutic effects, ionizing radiation (IR) increases the vascularity and invasiveness of surviving radioresistant cancer cells. This invasive phenotype of radioresistant cells is an upshot of IR-induced pro-survival and mitogenic signaling in cancer as well as endothelial cells. Here, we demonstrate that a plant flavonoid, silibinin can radiosensitize endothelial cells by inhibiting expression of pro-angiogenic factors. Combining silibinin with IR not only strongly down-regulated endothelial cell proliferation, clonogenicity and tube formation ability rather it strongly (p < 0.001) reduced migratory and invasive properties of PCa cells which were otherwise marginally affected by IR treatment alone. Most of the pro

  7. Off-axial acoustic radiation force of repulsor and tractor bessel beams on a sphere.

    Science.gov (United States)

    Silva, Glauber T; Lopes, J Henrique; Mitri, Farid G

    2013-06-01

    Acoustic Bessel beams are known to produce an axial radiation force on a sphere centered on the beam axis (on-axial configuration) that exhibits both repulsor and tractor behaviors. The repulsor and the tractor forces are oriented along the beam's direction of propagation and opposite to it, respectively. The behavior of the acoustic radiation force generated by Bessel beams when the sphere lies outside the beam's axis (off-axial configuration) is unknown. Using the 3-D radiation force formulas given in terms of the partial wave expansion coefficients for the incident and scattered waves, both axial and transverse components of the force exerted on a silicone- oil sphere are obtained for a zero- and a first-order Bessel vortex beam. As the sphere departs from the beam's axis, the tractor force becomes weaker. Moreover, the behavior of the transverse radiation force field may vary with the sphere's size factor ka (where k is the wavenumber and a is the sphere radius). Both stable and unstable equilibrium regions around the beam's axis are found, depending on ka values. These results are particularly important for the design of acoustical tractor beam devices operating with Bessel beams. PMID:25004483

  8. Design Specifications for a Radiation Tolerant Beam Loss Measurement ASIC

    CERN Document Server

    Venturini, G G; Effinger, E; Zamantzas, C

    2009-01-01

    A novel radiation-hardened current digitizer ASIC is in planning stage, aimed at the acquisition of the current signals from the ionization chambers employed in the Beam Loss Monitoring system at CERN. The purpose is to match and exceed the performance of the existing discrete component design, currently in operation in the Large Hadron Collider (LHC). The specifications include: a dynamic range of nine decades, defaulting to the 1 pA-1mA range but adjustable by the user, ability to withstand a total integrated dose of 10 kGy at least in 20 years of operation and user selectable integrating windows, as low as 500 ns. Moreover, the integrated circuit should be able to digitize currents of both polarity with a minimum number of external components and without needing any configuration. The target technology is the IBM 130nm CMOS process. The specifications, the architecture choices and the reasons on which they are based upon are discussed in this paper.

  9. Spectral attenuation of solar radiation in Patagonian fjord and coastal waters and implications for algal photobiology

    Science.gov (United States)

    Huovinen, Pirjo; Gómez, Iván

    2011-03-01

    The spectral attenuation of solar irradiation was measured during summer in two types of coastal waters in southern Chile, a north Patagonian fjord (Seno Reloncaví) and open coast (Valdivia). In order to relate the light availability with the light requirements of upper subtidal seaweeds, the saturating irradiance for photosynthesis ( Ek) from P- I curves was measured. In addition the UV risk was assessed. Based on the z1% of PAR, the lower limit of the euphotic zone in the studied systems averaged 21 m ( Kd 0.24 m -1) in Seno Reloncaví and 18 m ( Kd 0.27 m -1) in the coast of Valdivia. Photosynthesis of the studied seaweeds was saturated at markedly lower irradiances than found in their natural depths at the time of the study. Solar radiation penetrating into these depths at both locations largely supports the light requirements for the photosynthesis of subtidal species: 50-160 μmol m -2 s -1 for seaweeds from Seno Reloncaví (7 m tidal range) and 20-115 μmol m -2 s -1 for Valdivia assemblages (2 m tidal range). Optimal light conditions to saturate photosynthesis ( Ek) were present at 10-16 m water depth. The attenuation of solar irradiation did not vary significantly between the fjord and coastal sites of this study. However, the underwater light climates to which seaweeds are exposed in these sites vary significantly because of the stronger influence of tidal range affecting the fjord system as compared with the open coastal site. The patterns of UV-B penetration in these water bodies suggest that seaweeds living in upper littoral zones such as the intertidal and shallow subtidal (<3 m) may be at risk.

  10. Development of modulated electron beam for intensity modulated radiation therapy (IMRT) on a photocathode electron gun

    International Nuclear Information System (INIS)

    Radiation therapy of cancer is developing to un-uniform irradiation, for concentrating dose to a cancer tumor and reducing dose to normal tissue. As a step toward the Intensity modulated radiation therapy, we examined dynamic optical modulation of electron beam produced by a photocathode electron gun. Images on photo-masks were transferred onto a photocathode by relay imaging. Electron beam could be controlled by a remote mirror. Modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods. As a second step, optical modulation of electron beam and dynamic control succeeded by a digital micro mirror device (DMD). (author)

  11. EFFECT OF ELECTRON BEAM RADIATIONS ON ANXIETY IN EXPERIMENTAL ANIMAL MODELS

    OpenAIRE

    Deepa B; Shyamjith Manikkoth

    2015-01-01

    Objectives: The aim of the study was to test the effect of whole body electron beam radiation on anxiety statein Swiss albino mice. Methods: Mice were irradiated with three different doses (2Gy,4Gy,6Gy)of electron beam radiations.After 24hours of radiation exposure animals were taken for testing level of anxiety using elevated plus maze and light dark arena apparatus. Results: Whole body electron beam irradiation at doses of 2, 4 and 6Gy lead to significant (p

  12. Characteristics of liver tissue for attenuate the gamma radiation; Caracteristicas del tejido hepatico para atenuar la radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Arcos P, A.; Rodriguez N, S.; Pinedo S, A.; Amador V, P.; Chacon R, A.; Vega C, H.R. [Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2005-07-01

    It was determined the lineal attenuation coefficient of hepatic tissue before gamma radiation of a source of {sup 137} Cs. When exposing organic material before X or gamma radiation fields, part of the energy of the photons is absorbed by the material, while another part crosses it without producing any effect. The quantity of energy that is absorbed is a measure of the dose that receives the material. The three main mechanisms by means of which the gamma rays interacting with the matter are: The Photoelectric Effect, the Compton dispersion and the Even production; the sum of these three processes is translated in the attenuation coefficient of the radiation. In this work we have used hepatic tissue of bovine, as substitute of the human hepatic tissue, and we have measured the lineal attenuation coefficient for photons of 0.662 MeV. Through a series of calculations we have determined the lineal attenuation coefficient for photons from 10{sup -3} to 10{sup -5} MeV and the measured coefficient was compared with the one calculated. (Author)

  13. Experimental study of acoustic radiation force of an ultrasound beam on absorbing and scattering objects

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaeva, Anastasiia V., E-mail: niko200707@mail.ru; Kryzhanovsky, Maxim A.; Tsysar, Sergey A. [Department of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991 (Russian Federation); Kreider, Wayne [Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St. Seattle WA 98105 (United States); Sapozhnikov, Oleg A. [Department of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991 (Russian Federation); Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St. Seattle WA 98105 (United States)

    2015-10-28

    Acoustic radiation force is a nonlinear acoustic effect caused by the transfer of wave momentum to absorbing or scattering objects. This phenomenon is exploited in modern ultrasound metrology for measurement of the acoustic power radiated by a source and is used for both therapeutic and diagnostic sources in medical applications. To calculate radiation force an acoustic hologram can be used in conjunction with analytical expressions based on the angular spectrum of the measured field. The results of an experimental investigation of radiation forces in two different cases are presented in this paper. In one case, the radiation force of an obliquely incident ultrasound beam on a large absorber (which completely absorbs the beam) is considered. The second case concerns measurement of the radiation force on a spherical target that is small compared to the beam diameter.

  14. Radiation safety aspects of the operation of first three synchrotron beam lines of Indus-2.

    Science.gov (United States)

    Nayak, M K; Nair, Haridas G; Bakshi, A K; Sahani, P K; Singh, Sunil; Khan, Saleem; Verma, Dimple; Dev, Vipin; Sahu, T K; Khare, Mukesh; Kumar, Vijay; Bandyopadhyay, Tapas; Tripathi, R M; Sharma, D N

    2015-04-01

    Five synchrotron radiation beam lines are commissioned and now under regular operation at the Synchrotron Radiation Source, Indus-2 at Raja Ramanna Centre For Advanced Technology (RRCAT), Indore, India. Nine beam lines are under trial operation, and six beam lines are in the installation stage. In the early phase of installation of beam lines on Indus-2, three bending magnet beam lines, Extended X-ray Absorption Fine Structure (EXAFS, BL-8), Energy Dispersive X-ray Diffraction (EDXRD, BL-11) and Angle Dispersive X-ray Diffraction (ADXRD, BL-12), were installed and commissioned, after approval from Atomic Energy Regulatory Board (AERB), India. These beam lines are pink (BL-8), white (BL-11) and monochromatic (BL-12), which are housed in specially designed shielded hutches. In order to ensure safety of users and other working personnel from ionizing radiations present in these beam lines, several safety systems are incorporated and safety procedures are followed. The paper describes the radiological safety aspects of the three beam lines during its initial commissioning trials and also the measurements on radiation levels carried out in and around the beam line hutches. PMID:25209995

  15. Cone beam computed tomography radiation dose and image quality assessments.

    Science.gov (United States)

    Lofthag-Hansen, Sara

    2010-01-01

    Diagnostic radiology has undergone profound changes in the last 30 years. New technologies are available to the dental field, cone beam computed tomography (CBCT) as one of the most important. CBCT is a catch-all term for a technology comprising a variety of machines differing in many respects: patient positioning, volume size (FOV), radiation quality, image capturing and reconstruction, image resolution and radiation dose. When new technology is introduced one must make sure that diagnostic accuracy is better or at least as good as the one it can be expected to replace. The CBCT brand tested was two versions of Accuitomo (Morita, Japan): 3D Accuitomo with an image intensifier as detector, FOV 3 cm x 4 cm and 3D Accuitomo FPD with a flat panel detector, FOVs 4 cm x 4 cm and 6 cm x 6 cm. The 3D Accuitomo was compared with intra-oral radiography for endodontic diagnosis in 35 patients with 46 teeth analyzed, of which 41 were endodontically treated. Three observers assessed the images by consensus. The result showed that CBCT imaging was superior with a higher number of teeth diagnosed with periapical lesions (42 vs 32 teeth). When evaluating 3D Accuitomo examinations in the posterior mandible in 30 patients, visibility of marginal bone crest and mandibular canal, important anatomic structures for implant planning, was high with good observer agreement among seven observers. Radiographic techniques have to be evaluated concerning radiation dose, which requires well-defined and easy-to-use methods. Two methods: CT dose index (CTDI), prevailing method for CT units, and dose-area product (DAP) were evaluated for calculating effective dose (E) for both units. An asymmetric dose distribution was revealed when a clinical situation was simulated. Hence, the CTDI method was not applicable for these units with small FOVs. Based on DAP values from 90 patient examinations effective dose was estimated for three diagnostic tasks: implant planning in posterior mandible and

  16. Schistosoma mansoni polypeptides immunogenic in mice vaccinated with radiation-attenuated cercariae

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, J.P.; Strand, M.

    1987-10-01

    We compared the humoral immune response of mice protected against Schistosoma mansoni by vaccination with radiation-attenuated cercariae to that of patently infected mice, and we identified antigens that elicit a greater, or unique, immune response in the vaccinated mice. These comparisons were based upon radioimmunoprecipitations and immunodepletion of (/sup 35/S)methionine-labeled schistosomular and adult worm polypeptides, followed by one- and two-dimensional polyacrylamide gel analyses. The humoral responses of patently infected mice and of mice vaccinated once were remarkably similar and were directed against schistosome glycoproteins ranging in molecular size from greater than 300 to less than 10 kDa. Exposing mice to a second vaccination resulted in a marked change in the immune response, to one predominantly directed toward high molecular size glycoproteins. Sequential immunodepletion techniques identified five schistosomular and seven adult worm antigens that showed a greater or unique immunogenicity in vaccinated mice as compared with patently infected mice. These adult worm antigens were purified by preparative sequential immunoaffinity chromatography and used to prepare a polyclonal antiserum, anti-irradiated vaccine. This antiserum bound to the surface of live newly transformed and lung-stage schistosomula, as assessed by immunofluorescence assays, and was reactive with a number of /sup 125/I-labeled schistosomular surface polypeptides, including a doublet of 150 kDa that was also recognized by sera of vaccinated mice but not by sera of patently infected mice.

  17. Theoretical and experimental study of an energy-reinforced braking radiation photon beam

    International Nuclear Information System (INIS)

    This research thesis reports the theoretical study of a photon beam raised towards high energies, its experimental implementation, the definition of a gamma spectrometry method which aimed at checking various hypotheses used in the beam theoretical study. After a presentation of the theory of phenomena of electron braking radiation, of materialisation of photons into positon-negaton pair, and of issues related to multiple Coulomb diffusion, the author reports the study of the different solutions which allow a photon beam to be obtained. A braking radiation of mono-kinetic electron has been used. This braking radiation is reinforced by absorption of low energy protons in a column of lithium hydride. The author describes how the beam is built up, and the experimental approach. He describes how raw data are processed to get rid of the influence of the multiple Coulomb diffusion and of the braking radiation. Experimental results are compared with those obtained by convolution of photon spectra and differential cross section

  18. Gamma-ray beam attenuation as an auxiliary technique for the evaluation of the soil water retention curve

    Energy Technology Data Exchange (ETDEWEB)

    Bacchi, O.O.S.; Reichardt, K. [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil); Nielsen, D.R. [California Univ., Davis, CA (United States). Dept. of Land, Air and Water Resources; Oliveira, J.C.M

    1998-09-01

    The soil water retention curve is fundamental for the hydraulic characterization of a soil and has many applications in agricultural research as well as in practical agriculture. A new procedure for soil moisture and soil bulk density evaluation inside closed pressure chambers through gamma-ray beam attenuation is presented. The proposed procedure presents several advantages in relation to the traditional process: avoids the need of continuous sample manipulation; minimizes the problem of hysteresis; allows a more precise evaluation of soil moisture by taking into account changes of soil bulk density due to swelling or shrinking on addition or removal of water allows frequent evaluation of soil moisture without the need of opening the pressure chamber; allows a more precise judgement of equilibrium; reduces drastically the time of the determination of the retention curve and alloys easy automation of data acquisition by a computer. (author) 6 refs., 1 fig.

  19. Des-Aspartate-Angiotensin I Attenuates Mortality of Mice Exposed to Gamma Radiation via a Novel Mechanism of Action.

    Directory of Open Access Journals (Sweden)

    Hong Wang

    Full Text Available ACE inhibitors and ARBs (angiotensin receptor blockers have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways that are up-regulated during gamma radiation in organ systems such as the brain, lung, kidney, and bone marrow. ACE inhibitors inhibit ACE and attenuate the formation of angiotensin II from angiotensin I; ARBs block the angiotensin AT1 receptor and attenuate the actions of angiotensin II that are elicited through the receptor. DAA-I (des-aspartate-angiotensin I, an orally active angiotensin peptide, also attenuates the deleterious actions of angiotensin II. It acts as an agonist on the angiotensin AT1 receptor and elicits responses that oppose those of angiotensn II. Thus, DAA-I was investigated for its anticipated radioprotection in gamma irradiated mice. DAA-I administered orally at 800 nmole/kg/day for 30 days post exposure (6.4 Gy attenuated the death of mice during the 30-day period. The attenuation was blocked by losartan (50 nmole/kg/day, i.p. that was administered sequential to DAA-I administration. This shows that the radioprotection was mediated via the angiotensin AT1 receptor. Furthermore, the radioprotection correlated to an increase in circulating PGE2 of surviving animals, and this suggests that PGE2 is involved in the radioprotection in DAA-I-treated mice. At the hematopoietic level, DAA-I significantly improved two syndromes of myelosuppression (leucopenia and lymphocytopenia, and mice pre-treated with DAA-I prior to gamma irradiation showed significant improvement in the four myelodysplastic syndromes that were investigated, namely leucopenia, lymphocytopenia, monocytopenia and thrombocytopenia. Based on the known ability of PGE2 to attenuate the loss of functional hematopoietic stem and progenitor cells in radiation injury, we hypothesize that PGE2 mediated the action of DAA

  20. Optical Transition Radiation Measurement of Electron Beam for Beijing Free Electron Laser

    Institute of Scientific and Technical Information of China (English)

    ZHAO Qiang; XIE Jia-Lin; LI Yong-Gui; ZHUANG Jie-Jia

    2001-01-01

    We used transition radiation techniques instead of the original phosphor targets to improve the electronic beam diagnostic system at Beijing Free Electron Laser. The beam profile, size (3.3 × 2.4 mm), position and divergence angle (σrms = 2.5 mrad) in transverse have been obtained from optical transition radiation. We also present the experimental set-up and some preliminary results.

  1. Bronchiolitis obliterans organizing pneumonia after tangential beam irradiation to the breast. Discrimination from radiation pneumonitis

    Energy Technology Data Exchange (ETDEWEB)

    Nambu, Atsushi; Ozawa, Katsura; Kanazawa, Masaki; Miyata, Kazuyuki [Kofu Municipal Hospital (Japan); Araki, Tsutomu; Ohki, Zennosuke [Yamanashi Medical Coll., Tamaho (Japan)

    2002-06-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) secondary to tangential beam irradiation to the breast, which occurred seven months after the completion of radiotherapy. Although radiation pneumonitis is an alternative consideration, BOOP could be differentiated from it by its relatively late onset and extensive distribution, which did not respect the radiation field. This disease should always be kept in mind in patients with a history of tangential beam irradiation to the breast. (author)

  2. An analysis of whistler mode radiation from the Spacelab 2 electron beam

    Science.gov (United States)

    Farrell, W. M.; Gurnett, D. A.; Banks, P. M.; Bush, R. I.; Raitt, W. J.

    1988-01-01

    During the Spacelab 2 mission the plasma diagnostics package (PDP) was released from the Shuttle to free fly. At times during this free flight, when the PDP was magnetically connected to the Shuttle, Stanford's fast-pulsed electron generator, located in the Shuttle cargo bay, ejected a 1-keV 50-mA electron beam. The PDP plasma-wave instrument detected intense whistler-mode radiation during these beam ejections. This paper presents a study of a whistler mode emission detected during one particular continuous electron beam firing. Calculations indicate that the beam radiated approximately 1.6 mW in the whistler mode as the beam traversed the 200 m from the Shuttle to the PDP. The emissivity also decreased by about a factor of 10 over this same distance. The measured wave powers are 10 to the 7th greater than wave powers expected from incoherent Cerenkov radiation, verifying that the radiation is generated by a coherent process. Estimates of the emissivity based on measured electric field intensities in the beam indicate that the whistler-mode noise is produced by radiation from electron bunches created by an electrostatic beam-plasma instability.

  3. Accounting for Transverse Inhomogeneity of Radiation Beams in Laser Raman Scattering

    Science.gov (United States)

    Apanasevich, P. A.; Dashkevich, V. I.; Timofeeva, G. I.

    2016-05-01

    A simple method of accounting for transverse inhomogeneity of the pump and Stokes radiation beams in the description of stimulated Raman scattering (SRS) using intensity-transfer equations for interacting beams is proposed. Features of the method are illustrated using the calculated dependences of the Raman laser efficiency on the output mirror reflectivity and the pump pulse energy as examples.

  4. Characterization and application of two extrapolation chambers in standard X radiation beams

    International Nuclear Information System (INIS)

    The extrapolation chambers are ionization chambers with variable volume, and they are mainly utilized as beta radiation detectors. In this work two extrapolation chambers were characterized, a commercial PTW extrapolation chamber and another extrapolation chamber developed at the Calibration Laboratory of IPEN, for application as reference systems in mammography, conventional diagnostic radiology and radiotherapy beams. The results obtained from the characterization tests of the chamber response: leakage current, short- and medium terms stability, determination of the saturation currents and the ion collection efficiencies, angular and energy dependence, show that these extrapolation chambers may be utilized for low-energy X radiation beam dosimetry. The transmission factors in tissue and the calibration factors were also determined for all cited radiation qualities. Finally, a procedure was established for calibration of radiation detectors in standard X radiation beams, using the extrapolation chambers. (author)

  5. Verification of the dose attenuation of a newly developed vacuum cushion for intensity-modulated radiation therapy of prostate cancer.

    Science.gov (United States)

    Takakura, Toru; Ito, Yoshiyuki; Higashikawa, Akinori; Nishiyama, Tomohiro; Sakamoto, Takashi

    2016-07-01

    This study measured the dose attenuation of a newly developed vacuum cushion for intensity-modulated radiation therapy (IMRT) of prostate cancer, and verified the effect of dose-correction accuracy in a radiation treatment planning system (RTPS). The new cushion was filled with polystyrene foams inflated 15-fold (Sφ ≒ 1 mm) to reduce contraction caused by air suction and was compared to normal polystyrene foam inflated to 50-fold (Sφ ≒ 2 mm). The dose attenuation at several thicknesses of compression bag filled with normal and low-inflation materials was measured using an ionization chamber; and then the calculated RTPS dose was compared to ionization chamber measurements, while the new cushion was virtually included as region of interest in the calculation area. The dose attenuation rate of the normal cushion was 0.010 %/mm (R (2) = 0.9958), compared to 0.031 %/mm (R (2) = 0.9960) in the new cushion. Although the dose attenuation rate of the new cushion was three times that of the normal cushion, the high agreement between calculated dose by RTPS and ionization chamber measurements was within approximately 0.005 %/mm. Thus, the results of the current study indicate that the new cushion may be effective in clinical use for dose calculation accuracy in RTPS. PMID:27260347

  6. Why the radiation-attenuated cercarial immunization studies failed to guide the road for an effective schistosomiasis vaccine: A review

    OpenAIRE

    Rashika El Ridi; Hatem Tallima

    2014-01-01

    Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to 90% was achieved, providing a sound proof that vaccination against this infection is feasible. Exte...

  7. Radiation pressure cross section exerted on homogenous dielectric spherical particle by zeroth order Mathieu beams

    Science.gov (United States)

    Chafiq, A.; Belafhal, A.

    2016-08-01

    In this paper, we present a full calculation of radiation pressure cross section and optical forces exerted by linearly polarized zeroth order Mathieu beams on homogenous dielectric spherical particle in the framework of generalized Lorenz-Mie theory (GLMT). In this theory, the scattered fields are dependent upon the Mie scattering coefficients and the beam shape coefficients. So a new optical property such as force and torque appears by changing the beam profile and the nature of particle. In this way, this work is devoted to the analysis of both transverse and longitudinal optical forces exerted on a simple dielectric spherical particle by zeroth order Mathieu beams and zeroth order Bessel (which is a particular case of the first beam). Thus, through numerical simulations, we show that zeroth order Mathieu beams can't trap this particle but Bessel beam presents some dimensional stable equilibrium points.

  8. Summary report of working group 5: Beam and radiation generation, monitoring, and control

    Energy Technology Data Exchange (ETDEWEB)

    Church, Mike; /Fermilab; Kim, Ki-Yong; /Maryland U.

    2010-01-01

    This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

  9. A Monitor and Control System for the Synchrotron Radiation Beam Lines at DAΦNE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Three synchrotron radiation beam lines have been built on DAΦNE,the Frascati electron-positron accelerator.It is Possible to monitor and control all the elements on the beam lines using a modular network distributed I/O system by National Instrunments (FieldPoint) with Bridge VIEW/Lab VIEW programs,Two of these beam lines have radiation safety problems solved by two independent and redundant systems,using mechanical switches ,and S7-200 PLC's by Siemens.In this article our solution will be described in details.

  10. Transverse beam size measurement system using visible synchrotron radiation at HLS II

    Science.gov (United States)

    Tang, Kai; Sun, Bao-Gen; Yang, Yong-Liang; Lu, Ping; Tang, Lei-Lei; Wu, Fang-Fang; Cheng, Chao-Cai; Zheng, Jia-Jun; Li, Hao

    2016-09-01

    An interferometer system and an imaging system using visible synchrotron radiation (SR) have been installed in the Hefei Light Source (HLS) II storage ring. Simulations of these two systems are given using Synchrotron Radiation Workshop (SRW) code. With these two systems, the beam energy spread and the beam emittance can be measured. A detailed description of these two systems and the measurement method is given in this paper. The measurement results of beam size, emittance and energy spread are given at the end. Supported by National Natural Science Foundation of China (11105141, 11175173) and Upgrade Project of Hefei Light Source

  11. Summary report of working group 5: Beam and radiation generation, monitoring, and control

    CERN Document Server

    Church, Mike; 10.1063/1.3520295

    2012-01-01

    This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

  12. Real-time dosimetry in external beam radiation therapy

    Institute of Scientific and Technical Information of China (English)

    Ramachandran; Prabhakar

    2013-01-01

    With growing complexity in radiotherapy treatment delivery,it has become mandatory to check each and every treatment plan before implementing clinically.This process is currently administered by an independent secondary check of all treatment parameters and as a pre-treatment quality assurance (QA) check for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy treatment plans.Although pre-treatment IMRT QA is aimed to ensure the correct dose is delivered to the patient,it does not necessarily predict the clinically relevant patient dose errors.During radiotherapy,treatment uncertainties can affect tumor control and may increase complications to surrounding normal tissues.To combat this,image guided radiotherapy is employed to help ensure the plan conditions are mimicked on the treatment machine.However,it does not provide information on actual delivered dose to the tumor volume.Knowledge of actual dose delivered during treatment aid in confirming the prescribed dose and also to replan/reassess the treatment in situations where the planned dose is not delivered as expected by the treating physician.Major accidents in radiotherapy would have been averted if real time dosimetry is incorporated as part of the routine radiotherapy procedure.Of late real-time dosimetry is becoming popular with complex treatments in radiotherapy.Realtime dosimetry can be either in the form of point doses or planar doses or projected on to a 3D image dataset to obtain volumetric dose.They either provide entrance dose or exit dose or dose inside the natural cavities of a patient.In external beam radiotherapy,there are four different established platforms whereby the delivered dose information can be obtained:(1)Collimator;(2)Patient;(3)Couch;and(4)Electronic Portal Imaging Device.Current real-time dosimetric techniques available in radiotherapy have their own advantages and disadvantages and a combination of one or more of these methods provide vital information

  13. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710 Section 892.5710 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy...

  14. Accuracy and Radiation Dose of CT-Based Attenuation Correction for Small Animal PET: A Monte Carlo Simulation Study

    International Nuclear Information System (INIS)

    -Small animal PET allows qualitative assessment and quantitative measurement of biochemical processes in vivo, but the accuracy and reproducibility of imaging results can be affected by several parameters. The first aim of this study was to investigate the performance of different CT-based attenuation correction strategies and assess the resulting impact on PET images. The absorbed dose in different tissues caused by scanning procedures was also discussed to minimize biologic damage generated by radiation exposure due to PET/CT scanning. A small animal PET/CT system was modeled based on Monte Carlo simulation to generate imaging results and dose distribution. Three energy mapping methods, including the bilinear scaling method, the dual-energy method and the hybrid method which combines the kVp conversion and the dual-energy method, were investigated comparatively through assessing the accuracy of estimating linear attenuation coefficient at 511 keV and the bias introduced into PET quantification results due to CT-based attenuation correction. Our results showed that the hybrid method outperformed the bilinear scaling method, while the dual-energy method achieved the highest accuracy among the three energy mapping methods. Overall, the accuracy of PET quantification results have similar trend as that for the estimation of linear attenuation coefficients, whereas the differences between the three methods are more obvious in the estimation of linear attenuation coefficients than in the PET quantification results. With regards to radiation exposure from CT, the absorbed dose ranged between 7.29-45.58 mGy for 50-kVp scan and between 6.61-39.28 mGy for 80-kVp scan. For 18F radioactivity concentration of 1.86x105 Bq/ml, the PET absorbed dose was around 24 cGy for tumor with a target-to-background ratio of 8. The radiation levels for CT scans are not lethal to the animal, but concurrent use of PET in longitudinal study can increase the risk of biological effects. The

  15. Beam Propagation Method Calculating Attenuated Total Reflection Spectra to Excite Hybridized Surface Plasmon Polaritons

    Directory of Open Access Journals (Sweden)

    Hongli Zhou

    2015-08-01

    Full Text Available Using the beam propagation method, an analytical expression of the reflection spectra of a Kretschmann configuration is derived in order to excite hybridized surface plasmonic polaritons (HSPPs. In this configuration, the cladding is a uniaxial dielectric with the optical axis parallel to the interface. The validity of the analytical expression is confirmed by a finite-difference time-domain algorithm and a reported experimental result, respectively. Based on this expression, the properties and the conditions for excitation of the HSPPs are discussed in detail, with regard to the strongly anisotropic cladding and the weakly anisotropic cladding.

  16. Off-axial acoustic radiation force of pressor and tractor Bessel beams on a sphere

    CERN Document Server

    Silva, Glauber T; Lobo, Tiago P; Mitri, Farid G

    2012-01-01

    Acoustic Bessel beams are known to produce an axial radiation force on a sphere centered on the beam axis (on-axial configuration) that exhibits both "pressor" and "tractor" behaviors. The pressor and the tractor forces are oriented along the beam's direction of propagation and opposite to it, respectively. The behavior of the acoustic radiation force generated by Bessel beams when the sphere lies outside the beam's axis (off-axial configuration) is unknown. Using the 3D radiation force formulas given in terms of the partial wave expansion coefficients for the incident and scattered waves, both axial and transverse components of the force exerted on a silicone-oil sphere are obtained for a zero- and a first-order Bessel vortex beam. As the sphere departs from the beam's axis, the tractor force becomes weaker. Moreover, the behavior of the transverse radiation force field may vary with the sphere's size factor $ka$ (where $k$ is the wavenumber and $a$ is the sphere radius). Both stable and unstable equilibrium...

  17. Feasibility of optical diffraction radiation for a non-invasive low-emittance beam diagnostics

    CERN Document Server

    Urakawa, J; Kubo, K; Kuroda, S; Terunuma, N; Kuriki, M; Okugi, T; Naito, T; Araki, S; Potylitsin, A P; Naumenko, G A; Karataev, P; Potylitsyna, N A; Vnukov, I; Hirose, T; Hamatsu, R; Muto, T; Ikezawa, M; Shibata, Y

    2001-01-01

    A 'proof-of-principle' experiment on the optical diffraction radiation (ODR) as a single-pulse beam profile monitor is planned using an electron beam extracted from the KEK-ATF damping ring. The main goals of this experiment are the following: (i) To measure the yield and the angular distributions of the optical diffraction radiation from a large-size target at different wavelengths, impact parameters and beam characteristics for a comparison with analogous characteristics of optical transition radiation from a foil with identical optical parameters and for a verification of the model assumption (perfectly conducting semi-infinite target). (ii) To investigate the ODR angular distributions from a tilted target with a slit for observing the interference effects. (iii) To compare the results obtained by simulations based on classical approaches, taking into account the optical characteristics of the equipment and the beam parameters. (iv) To estimate the prospects of using ODR as a new non-invasive tool for ultr...

  18. Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures

    International Nuclear Information System (INIS)

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-off, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, multipactoring inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation when the machine is tuned for 130 MeV operation

  19. Radiation losses in PLT during neutral beam and ICRF heating experiments

    International Nuclear Information System (INIS)

    Radiation and charge exchange losses in the PLT tokamak are compared for discharges with ohmic heating only (OH), and with additional heating by neutral beams (NB) or RF in the ion cyclotron frequency range (ICRF). Spectroscopic, bolometric and soft x-ray diagnostics were used. The effects of discharge cleaning, vacuum wall gettering, and rate of gas inlet on radiation losses from OH plasmas and the correlation between radiation from plasma core and edge temperatures are discussed

  20. Producing acoustic 'Frozen Waves': Simulated experiments with diffraction/attenuation resistant beams, in lossy media

    CERN Document Server

    Prego-Borges, Jose' L; Recami, Erasmo; Tavares-Costa, Eduardo

    2013-01-01

    The so-called Localized Waves (LW), and the "Frozen Waves" (FW), have arisen significant attention in the areas of Optics and Ultrasound, because of their surprising energy localization properties. The LWs resist the effects of diffraction for large distances, and possess an interesting self-reconstruction (self-healing) property, after obstacles with size smaller than the antenna's; while the FWs, a sub-class of theirs, offer the possibility of arbitrarily modeling the field longitudinal intensity pattern inside a prefixed interval, for instance 0 < z < L, of the wave propagation axis. More specifically, the FWs are localized fields "at rest", that is, with a static envelope (within which only the carrier wave propagates), and can be endowed moreover with a high transverse localization. In this paper we investigate by simulated experiments, various cases of generation of ultrasonic FW fields, with frequency f_o = 1 MHz in a water-like medium, taking account of the effects of attenuation. We present res...

  1. Effects of high-energy-pulse-electron beam radiation on biomacromolecules

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    To study the molecular mechanism of high mutation frequency induced by high-energy-pulse-electron (HEPE) beam radiation, the effects of HEPE radiation on yeast cells, plasma membrane, plasmid DNA, and protein activity were investigated by means of cell counting, gel electrophoresis, AO/EB double fluorescent staining, etc. The results showed that the viability of yeast cells declined statistically with increase of absorbed doses. The half lethal dose (LD50) was 134 Gy. HEPE beam radiation had little influence on the function of plasma membrane and protein, while it could induce much DNA damage of single strand breaks (SSB) and double strand breaks (DSB) that were required for gene mutation. The G-value for DSB formation of HEPE beam radiation in aqueous solution was 5.7 times higher than that caused by 60Co gamma rays. HEPE can be a new effective method for induced mutation breeding and deserves further research in the future.

  2. Evaluation of ozone concentration for a white beam line hutch at Indus-2 synchrotron radiation source

    International Nuclear Information System (INIS)

    In the synchrotron radiation source Indus-2, 26 synchrotron radiation beam lines are planned, out of which 7 beam lines are operational and several are in installation stage. For carrying out experiments, SR beam is brought out to air through the beam lines (which are housed in shielded hutches). Due to the interaction of SR with air, ozone is produced, which is a noxious gas and is hazardous, if inhaled in excess. The production of ozone is high in white beam lines in comparison with pink and monochromatic beam lines. In the present paper ozone generation for a white beam line of Indus-2 is estimated. The ozone production rate, saturation concentration, ventilation rate and delay time are also estimated. The saturation concentration of ozone for the white beam line (energy dispersive X-ray diffraction beam line) BL-11 was found to be 0.965 ppm for 100 cm interaction path length and 51.45 m3 hutch volume without any ventilation. The paper presents the details of the calculation and the results. (author)

  3. Effect of electron beam radiations on anxiety in experimental animal models

    International Nuclear Information System (INIS)

    Exposures to ionizing radiation have been an inevitable part of the environment. This type of radiation can disrupt atoms, creating positive and negative charged particles, and cause biological harm. Ionizing radiation includes X-rays, gamma rays, alpha particles, beta particles and neutrons. They have the potential to cause both beneficial and harmful effects. There are concerns about these radiations as they are widely used in hospitals for treatment and diagnosis of various diseases. The present work was designed to test the effect of whole body electron beam radiation on anxiety in mice using the Elevated plus maze and Light dark arena, the commonly used models for assessing anxiety in rodents. Mice were irradiated with three different doses (2 Gy, 4 Gy and 6 Gy) of electron beam radiations. Statistical analysis revealed that whole body irradiation of the moderate dose range (2-6 Gy) of electron beam leads to a significant (p<0.001) anxiogenic activity in irradiated mice. Electron beam induced anxiety can be due to radiation induced reactive oxygen species in brain. (author)

  4. Beam Size Measurement by Optical Diffraction Radiation and Laser System for Compton Polarimeter

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chuyu [Peking Univ., Beijing (China)

    2012-12-31

    Beam diagnostics is an essential constituent of any accelerator, so that it is named as "organs of sense" or "eyes of the accelerator." Beam diagnostics is a rich field. A great variety of physical effects or physical principles are made use of in this field. Some devices are based on electro-magnetic influence by moving charges, such as faraday cups, beam transformers, pick-ups; Some are related to Coulomb interaction of charged particles with matter, such as scintillators, viewing screens, ionization chambers; Nuclear or elementary particle physics interactions happen in some other devices, like beam loss monitors, polarimeters, luminosity monitors; Some measure photons emitted by moving charges, such as transition radiation, synchrotron radiation monitors and diffraction radiation-which is the topic of the first part of this thesis; Also, some make use of interaction of particles with photons, such as laser wire and Compton polarimeters-which is the second part of my thesis. Diagnostics let us perceive what properties a beam has and how it behaves in a machine, give us guideline for commissioning, controlling the machine and indispensable parameters vital to physics experiments. In the next two decades, the research highlight will be colliders (TESLA, CLIC, JLC) and fourth-generation light sources (TESLA FEL, LCLS, Spring 8 FEL) based on linear accelerator. These machines require a new generation of accelerator with smaller beam, better stability and greater efficiency. Compared with those existing linear accelerators, the performance of next generation linear accelerator will be doubled in all aspects, such as 10 times smaller horizontal beam size, more than 10 times smaller vertical beam size and a few or more times higher peak power. Furthermore, some special positions in the accelerator have even more stringent requirements, such as the interaction point of colliders and wigglor of free electron lasers. Higher performance of these accelerators increases the

  5. Efficacy of electron beams in radiation disinfestation of jute bags

    International Nuclear Information System (INIS)

    An irradiator generating electron radiation may be employed for radiation disinfestation of jute bags infested with larvae and adults of the confused flour beetle, Tribolium confusum DuV., if they are created as separate units or small batches, containing up to 40 bags, and are irradiated with a 2 kGy dose. (author)

  6. ATLAS Transition Radiation Tracker test-beam results

    CERN Document Server

    Åkesson, T; Baker, K; Baron, S; Benjamin, D; Bertelsen, H; Bondarenko, V; Bychkov, V; Callahan, J; Capéans-Garrido, M; Cardiel-Sas, L; Catinaccio, A; Cetin, S A; Cwetanski, Peter; Dam, M; Danielsson, H; Dittus, F; Dolgoshein, B A; Dressnandt, N; Driouichi, C; Ebenstein, W L; Eerola, Paule Anna Mari; Farthouat, Philippe; Fedin, O; Froidevaux, D; Gagnon, P; Grichkevitch, Y; Grigalashvili, N S; Hajduk, Z; Hansen, P; Kayumov, F; Keener, P T; Kekelidze, G D; Khristatchev, A; Konovalov, S; Koudine, L; Kovalenko, S; Kowalski, T; Kramarenko, V A; Krüger, K; Laritchev, A; Lichard, P; Luehring, F C; Lundberg, B; Maleev, V; Markina, I; McFarlane, K W; Mialkovski, V; Mitsou, V A; Mindur, B; Morozov, S; Munar, A; Muraviev, S; Nadtochy, A; Newcomer, F M; Ögren, H O; Oh, S H; Oleshko, S; Olszowska, J; Passmore, S; Patritchev, S; Peshekhonov, V D; Petti, R; Price, M; Rembser, C; Rohne, O; Romaniouk, A; Rust, D R; Ryabov, Yu; Shchegelskii, V; Seliverstov, D M; Shin, T; Shmeleva, A; Smirnov, S; Sosnovtsev, V V; Soutchkov, V; Spiridenkov, E; Tikhomirov, V; Van Berg, R; Vassilakopoulos, V I; Vassilieva, L; Wang, C; Williams, H H; Zalite, A

    2004-01-01

    Several prototypes of the Transition Radiation Tracker for the ATLAS experiment at the LHC have been built and tested at the CERN SPS accelerator. Results from detailed studies of the straw-tube hit registration efficiency and drift-time measurements and of the pion and electron spectra without and with radiators are presented. (10 refs).

  7. Smith-Purcell terahertz radiation from laser modulated electron beam over a metallic grating

    Science.gov (United States)

    Kumar, Pawan; Bhasin, Lalita; Tripathi, V. K.; Kumar, Ashok; Kumar, Manoj

    2016-09-01

    We propose a novel scheme of terahertz (THz) radiation generation from the beat frequency modulation of an electron beam by two co-propagating lasers and the generation of terahertz radiation by the modulated beam passing over a periodic metallic grating. The lasers cause velocity modulation of the beam by exerting a longitudinal ponderomotive force on it. In the drift space between the modulator and metallic grating, the velocity modulation translates into density and current modulation. The modulated beam, propagating over the grating of specific wave number, induces space periodic image current in the conductor that emits beat frequency Smith-Purcell radiation. With 1 μm, 4 × 1016 W/cm2 lasers, beam current modulation of the order of 50% can be achieved at optimum lengths of the modulator and drift space. Employing 10 mA, 0.5 MeV short-period electron beam, propagating at a height of 50 μ m above the grating of period 150 μm, one may obtain THz radiated power of the order of 6 mW at 10 THz.

  8. A study of chemical composition and radiation attenuation properties in clinoptilolite-rich natural zeolite from Turkey

    International Nuclear Information System (INIS)

    Clinoptilolite, a type of natural zeolite, has been commonly used as pozzolanic additive in concrete. This type of natural zeolite is generally used as a mineral admixture by substitution in Portland cement to produce high performance concretes. In the present study, the major, minor and trace element levels present in the clinoptilolite-rich natural zeolite (CRNZ) have been determined using a wavelength dispersive X-ray fluorescence spectrometer. Also, the clinoptilolite-rich natural zeolite has been compared with Portland cement with respect to the radiation attenuation properties. From the results it can be concluded that due to the natural radioactive content of clinoptilolite-rich natural zeolite (CRNZ) even if it is in trace level and also due to the poorer X-ray attenuation compared with Portland cement, special care should be taken to use this type of natural zeolite as blend materials in cements, etc.

  9. Acoustical radiation torque and force for spheres and Bessel beam extinction efficiency

    Science.gov (United States)

    Marston, Philip L.; Zhang, Likun

    2014-11-01

    The scattering of optical and acoustical beams is relevant to the levitation and manipulation of drops. Here we examine theoretical developments in the acoustical case. We previously showed how the optical theorem for extinction can be extended to invariant beams. The example of a sphere in a Bessel beam facilitates the direct comparison with a circular disc computed using Babinet's principle and the Kirchhoff approximation. In related work, by considering traveling or standing wave first-order vortex beams we previously showed that the radiation torque is the ratio of the absorbed power and the radian acoustic frequency. By modifying the scattering to account for the viscosity of the surrounding fluid in the analysis of the absorbed power, approximations for radiation torque and force are obtained at long wavelengths in special cases and these can be compared with results published elsewhere.

  10. Resonant terahertz radiation from warm collisional inhomogeneous plasma irradiated by two Gaussian laser beams

    Science.gov (United States)

    Niknam, A. R.; Banjafar, M. R.; Jahangiri, F.; Barzegar, S.; Massudi, R.

    2016-05-01

    Terahertz (THz) radiation generation by the interaction of two co-propagating high intensity laser beams with a warm collisional inhomogeneous plasma is analytically investigated. By presenting the dielectric permittivity of plasma and taking into account the ponderomotive force, the nonlinear current at THz frequency is obtained. A secondary resonant enhancement of THz radiation is observed, in addition to that occurs at the plasma frequency, which can be tuned by plasma density and temperature. Moreover, we show that for each beat frequency, there exists an optimum temperature at which THz radiation is maximized. It is also shown that the power and efficiency of THz radiation decrease by increasing the collision frequency.

  11. Betatron radiation based diagnostics for plasma wakefield accelerated electron beams at the SPARC_LAB test facility

    Science.gov (United States)

    Shpakov, V.; Anania, M. P.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Curcio, A.; Dabagov, S.; Ferrario, M.; Filippi, F.; Marocchino, A.; Paroli, B.; Pompili, R.; Rossi, A. R.; Zigler, A.

    2016-09-01

    Recent progress with wake-field acceleration has shown a great potential in providing high gradient acceleration fields, while the quality of the beams remains relatively poor. Precise knowledge of the beam size at the exit from the plasma and matching conditions for the externally injected beams are the key for improvement of beam quality. Betatron radiation emitted by the beam during acceleration in the plasma is a powerful tool for the transverse beam size measurement, being also non-intercepting. In this work we report on the technical solutions chosen at SPARC_LAB for such diagnostics tool, along with expected parameters of betatron radiation.

  12. Seeing the invisible: Direct visualization of therapeutic radiation beams using air scintillation

    Energy Technology Data Exchange (ETDEWEB)

    Fahimian, Benjamin; Türkcan, Silvan; Kapp, Daniel S.; Pratx, Guillem, E-mail: pratx@stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 (United States); Ceballos, Andrew [Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States)

    2014-01-15

    Purpose: To assess whether air scintillation produced during standard radiation treatments can be visualized and used to monitor a beam in a nonperturbing manner. Methods: Air scintillation is caused by the excitation of nitrogen gas by ionizing radiation. This weak emission occurs predominantly in the 300–430 nm range. An electron-multiplication charge-coupled device camera, outfitted with an f/0.95 lens, was used to capture air scintillation produced by kilovoltage photon beams and megavoltage electron beams used in radiation therapy. The treatment rooms were prepared to block background light and a short-pass filter was utilized to block light above 440 nm. Results: Air scintillation from an orthovoltage unit (50 kVp, 30 mA) was visualized with a relatively short exposure time (10 s) and showed an inverse falloff (r{sup 2} = 0.89). Electron beams were also imaged. For a fixed exposure time (100 s), air scintillation was proportional to dose rate (r{sup 2} = 0.9998). As energy increased, the divergence of the electron beam decreased and the penumbra improved. By irradiating a transparent phantom, the authors also showed that Cherenkov luminescence did not interfere with the detection of air scintillation. In a final illustration of the capabilities of this new technique, the authors visualized air scintillation produced during a total skin irradiation treatment. Conclusions: Air scintillation can be measured to monitor a radiation beam in an inexpensive and nonperturbing manner. This physical phenomenon could be useful for dosimetry of therapeutic radiation beams or for online detection of gross errors during fractionated treatments.

  13. Radiation hardness of polysiloxane scintillators analyzed by ion beam induced luminescence

    Energy Technology Data Exchange (ETDEWEB)

    Quaranta, A., E-mail: quaranta@ing.unitn.i [University of Trento, Dipartimento di Ingegneria dei Materiali e delle Tecnologie Industriali - DIMTI, Via Mesiano 77, I-38050 Povo, Trento (Italy); INFN, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy); Carturan, S. [Universita di Padova, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy); Marchi, T.; Antonaci, A. [INFN, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy); Scian, C. [Universita di Padova, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy); Kravchuk, V.L. [Universita di Bologna, Dipartimento di Fisica, Viale Carlo Berti Pichat 6, I-40127 Bologna (Italy); Degerlier, M.; Gramegna, F. [INFN, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy); Maggioni, G. [Universita di Padova, Laboratori Nazionali di Legnaro, Via dell' Universita 2, I-35020 Legnaro, Padova (Italy)

    2010-10-01

    The radiation hardness of polysiloxane based scintillators has been measured by ion beam induced luminescence (IBIL). The light intensity as a function of the irradiation fluence with an He{sup +} beam at 1.8 MeV (1.0 {mu}A/cm{sup 2}) has been measured on undoped polymers synthesized with different amounts of phenyl units and on polysiloxanes doped with two different dye molecules (BBOT and Lumogen Violet) sensitizing the scintillation yield.

  14. Radiation Exposure of Patients by Cone Beam CT during Endobronchial Navigation - A Phantom Study

    OpenAIRE

    Hohenforst-Schmidt, Wolfgang; Banckwitz, Rosemarie; Zarogoulidis, Paul; Vogl, Thomas; Darwiche, Kaid; Goldberg, Eugene; Huang, Haidong; Simoff, Michael; Li, Qiang; Browning, Robert; Freitag, Lutz; Turner, J. Francis; Pivert, Patrick Le; Yarmus, Lonny; Zarogoulidis, Konstantinos

    2014-01-01

    Rationale: Cone Beam Computed Tomography imaging has become increasingly important in many fields of interventional therapies. Objective: Lung navigation study which is an uncommon soft tissue approach. Methods: As no effective organ radiation dose levels were available for this kind of Cone Beam Computed Tomography application we simulated in our DynaCT (Siemens AG, Forchheim, Germany) suite 2 measurements including 3D acquisition and again for 3D acquisition and 4 endobronchial navigation m...

  15. Noninvasive measurement of micron electron beam size of high energy using diffraction radiation

    CERN Document Server

    Naumenko, G A

    2003-01-01

    Treatments of the usage of diffraction radiation from the relativistic electrons moving though a conductive slit for the transverse beam size measurement encounter hard limitation of the method sensitivity for the electron energy larger than 1 GeV. We consider in this article a possibility of application of the artificial phase shift, which can take place when transverse electron position varies. This allows us to realize the measurements of transverse size of supper-relativistic electron beams with the small emittance.

  16. Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

    International Nuclear Information System (INIS)

    Ionizing radiation-induced hematopoietic injury could occur either due to accidental exposure or due to diagnostic and therapeutic interventions. Currently there is no approved drug to mitigate radiation toxicity in hematopoietic cells. This study investigates the potential of ON 01210.Na, a chlorobenzylsulfone derivative, in ameliorating radiation-induced hematopoietic toxicity when administered after exposure to radiation. We also investigate the molecular mechanisms underlying this activity. Male C3H/HeN mice (n = 5 mice per group; 6-8 weeks old) were exposed to a sub-lethal dose (5 Gy) of γ radiation using a 137Cs source at a dose rate of 0.77 Gy/min. Two doses of ON 01210.Na (500 mg/kg body weight) were administered subcutaneously at 24 h and 36 h after radiation exposure. Mitigation of hematopoietic toxicity by ON 01210.Na was investigated by peripheral white blood cell (WBC) and platelet counts at 3, 7, 21, and 28 d after radiation exposure. Granulocyte macrophage colony forming unit (GM-CFU) assay was done using isolated bone marrow cells, and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) was performed on bone marrow sections at 7 d post-exposure. The DNA damage response pathway involving ataxia telangiectasia mutated (ATM) and p53 was investigated by Western blot in bone marrow cells at 7 d post-exposure. Compared to the vehicle, ON 01210.Na treated mice showed accelerated recovery of peripheral WBC and platelet counts. Post-irradiation treatment of mice with ON 01210.Na also resulted in higher GM-CFU counts. The mitigation effects were accompanied by attenuation of ATM-p53-dependent DNA damage response in the bone marrow cells of ON 01210.Na treated mice. Both phospho-ATM and phospho-p53 were significantly lower in the bone marrow cells of ON 01210.Na treated than in vehicle treated mice. Furthermore, the Bcl2:Bax ratio was higher in the drug treated mice than the vehicle treated groups. ON 01210.Na treatment significantly

  17. Image-guided small animal radiation research platform: calibration of treatment beam alignment

    International Nuclear Information System (INIS)

    Small animal research allows detailed study of biological processes, disease progression and response to therapy with the potential to provide a natural bridge to the clinical environment. The small animal radiation research platform (SARRP) is a portable system for precision irradiation with beam sizes down to approximately 0.5 mm and optimally planned radiation with on-board cone-beam CT (CBCT) guidance. This paper focuses on the geometric calibration of the system for high-precision irradiation. A novel technique for the calibration of the treatment beam is presented, which employs an x-ray camera whose precise positioning need not be known. Using the camera system we acquired a digitally reconstructed 3D 'star shot' for gantry calibration and then developed a technique to align each beam to a common isocenter with the robotic animal positioning stages. The calibration incorporates localization by cone-beam CT guidance. Uncorrected offsets of the beams with respect to the calibration origin ranged from 0.4 mm to 5.2 mm. With corrections, these alignment errors can be reduced to the sub-millimeter range. The calibration technique was used to deliver a stereotactic-like arc treatment to a phantom constructed with EBT Gafchromic films. All beams were shown to intersect at a common isocenter with a measured beam (FWHM) of approximately 1.07 mm using the 0.5 mm collimated beam. The desired positioning accuracy of the SARRP is 0.25 mm and the results indicate an accuracy of 0.2 mm. To fully realize the radiation localization capabilities of the SARRP, precise geometric calibration is required, as with any such system. The x-ray camera-based technique presented here provides a straightforward and semi-automatic method for system calibration.

  18. Analytical study of the heat loss attenuation by clothing on thermal manikins under radiative heat loads

    NARCIS (Netherlands)

    Hartog, E.A. den; Havenith, G.

    2010-01-01

    For wearers of protective clothing in radiation environments there are no quantitative guidelines available for the effect of a radiative heat load on heat exchange. Under the European Union funded project ThermProtect an analytical effort was defined to address the issue of radiative heat load whil

  19. Electron Beam Spectrum Diagnostics with Optical Transition Radiation on the Beijing Free-Electron Laser

    Institute of Scientific and Technical Information of China (English)

    李泉凤; 吴频; 高建江; 吴刚

    2004-01-01

    A measurement system was developed to measure the electron beam spectrum of the Beijing free-electron laser based on the optical transition radiation (OTR). This paper describes the system, which consists of a 32-channel high resolution of 0.02% OTR detector, especially the spectrometer. The OTR angular-distribution pattern at the focal plane has two apexes, but the two apexes are smoothed out due to the electron beam energy distribution. The energy spectrum can be measured if the magnet energy resolution is higher than 0.7% to distinguish the electron beam energy distribution.

  20. Radiative and collisional processes of highly charged heavy ions studied with electron beam ion traps

    International Nuclear Information System (INIS)

    We have been studying radiative and collisional processes of highly charged heavy ions using two electron beam ion traps (EBITs) at the University of Electro-Communications (UEC/Tokyo); one is the Tokyo-EBIT constructed in 1995 for the operation with a high energy (up to 200 keV) electron beam, and another is “CoBIT” constructed recently for the operation with a low energy (< 1 keV) electron beam. Recent activities using the two EBITs are presented. (author)

  1. Effects of transverse electron beam size on transition radiation angular distribution

    Energy Technology Data Exchange (ETDEWEB)

    Chiadroni, E., E-mail: enrica.chiadroni@lnf.infn.it [Laboratori Nazionali di Frascati-INFN, via E. Fermi, 40, 00044 Frascati (Italy); Castellano, M. [Laboratori Nazionali di Frascati-INFN, via E. Fermi, 40, 00044 Frascati (Italy); Cianchi, A. [University of Rome ' Tor Vergata' and INFN-Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy); Honkavaara, K.; Kube, G. [Deutsches Elektronen-Synchrotron, Notkestrasse 85, 22607 Hamburg (Germany)

    2012-05-01

    In this paper we consider the effect of the transverse electron beam size on the Optical Transition Radiation (OTR) angular distribution in case of both incoherent and coherent emission. Our results confute the theoretical argumentations presented first in Optics Communications 211, 109 (2002), which predicts a dependence of the incoherent OTR angular distribution on the beam size and emission wavelength. We present here theoretical and experimental data not only to validate the well-established Ginzburg-Frank theory, but also to show the impact of the transverse beam size in case of coherent emission.

  2. Beam conditions for radiation generated by an electromagnetic Hermite-Gaussian model source

    Institute of Scientific and Technical Information of China (English)

    LI Jia; XIN Yu; CHEN Yan-ru

    2011-01-01

    @@ Within the framework of the correlation theory of electromagnetic laser beams, the far field cross-spectral density matrix of the light radiated from an electromagnetic Hermite-Gaussian model source is derived.By utilizing the convergence property of Hermite polynomials, the conditions of the matrices for the source to generate an electromagnetic Hermite-Gaussian beam are obtained.Furthermore, in order to generate a scalar Hermite-Gaussian model beam, it is required that the source should be locally rather coherent in the spatial domain.

  3. Overview of nonintercepting beam-size monitoring with optical diffraction radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, Alex H.; /Fermilab

    2010-08-01

    The initial demonstrations over the last several years of the use of optical diffraction radiation (ODR) as nonintercepting electron-beam-parameter monitors are reviewed. Developments in both far-field imaging and near-field imaging are addressed for ODR generated by a metal plane with a slit aperture, a single metal plane, and two-plane interferences. Polarization effects and sensitivities to beam size, divergence, and position will be discussed as well as a proposed path towards monitoring 10-micron beam sizes at 25 GeV.

  4. Economical aspects of radiation sterilization with electron beam

    International Nuclear Information System (INIS)

    Radiation sterilization has been introduced in Poland in the early seventies. Since then continuous progress is observed in quantity of sterilized products. The commercial irradiation facility was built in 1993 to fulfill growing demands for radiation service. The real costs of running this plant were shown. The share of the cost of investment and the cost of maintenance and spare parts in accelerator exploitation, as well as the cost of one hour accelerator exploitation against time of one year accelerator exploitation were taken into account

  5. Use of high-power electron beam radiation for the treatment of municipal and industrial wastes

    International Nuclear Information System (INIS)

    One of the factors impeding the use of ionizing radiation for waste treatment has been the relatively high cost of large radiation sources. This obstacle has been reduced by the recent development of powerful electron beam accelerators that are now being used by many manufacturers to crosslink plastic and rubber compounds, and to sterilize ethical products. The industrial demand for radiation processing equipment has produced a new technology which can be applied to the irradiation of waste materials. Electron accelerators can now provide 150 kW of useful beam power for continuous service. Such machines could process 3.1 MGD(million US gallons daily) of water to an average dose of 0.1 Mrad. The unit cost for the radiation process would be about $0.22 per 1000 gallons. Larger systems delivering up to a megawatt of power could be developed within a few years if needed for large-scale applications. Such equipment would bring the radiation processing cost down still further and would increase the capacity to about 22 MGD. This throughput would be comparable with the waste water effluent of large sewage treatment plants in the New York City area. High-power electron beams may be particularly useful in the treatment of gaseous wastes. The irradiation of stack gases from large electric power stations, a process that is now being investigated in Japan, is a possible application that could justify the development of multi-megawatt electron beam systems. (Author)

  6. Audit of high energy therapy beams in hospital oncology departments by the National Radiation Laboratory

    International Nuclear Information System (INIS)

    In 1993 the output of every high energy radiotherapy beam used clinically in New Zealand was measured by National Radiation Laboratory (NRL) staff using independent dosimetry equipment. The purpose of this was to audit the dosimetry that is used by hospital physicists for the basis of patient treatments, and to uncover any errors that may be clinically significant. This report analyses the uncertainties involved in comparing the NRL and hospital measurements, and presents the results of the 1993 audit. The overall uncertainty turns out to be about 1.5%. The results for linear accelerator photon beams are consistent with a purely random variation within this uncertainty. Electron beams show some small errors beyond the expected uncertainty. Gamma beams have the potential to be the most accurately measured, but in practice are less accurately measured than linear accelerator beams. None of the disagreements indicated an error of clinical significance. 8 refs., 3 figs., 2 tabs

  7. Calculation of radiation acoustical fields from phased arrays with nonparaxial multi-Gaussian beam model

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xinyu; GANG Tie; ZHANG Bixing

    2009-01-01

    A nonparaxial multi-Gaussian beam model based on the rectangular aperture is proposed in order to overcome the hmitation of paraxial Gaussian beam model which losing accuracy in off-axis beam fields. With the method, acoustical field generated by an ultra-sonic linear phased array transducer is calculated and compared with the corresponding field obtained by Rayleigh-Sommerfeld integral, paraxial multi-Gaussian beam model, and Fraunhof-fer approximation method. Simulation examples show that nonparaxial multi-Gaussian beam model is not limited by the paraxial approximation condition and can predict efficiently and accurately the acoustical field radiated by a linear phased array transducer over a wide range of steering angles.

  8. Synchrotron Radiation and beam tube vacuum in a Very Large Hadron Collider; Stage 1 VLHC

    International Nuclear Information System (INIS)

    Synchrotron radiation induced photodesorption in particle accelerators may lead to pressure rise and to beam-gas scattering losses, finally affecting the beam lifetime. We discuss the beam tube vacuum in the low field Stage 1 Very Large Hadron Collider VLHC. Since VLHC Stage 1 has a room temperature beam tube, a non-evaporable getter (NEG St101 strip) pumping system located inside a pumping antechamber, supplemented by lumped ion pumps for pumping methane is considered. A possible beam conditioning scenario is presented for reaching design intensity. The most important results are summarized in this paper. More detailed reports of the calculations will be presented at the PAC2001 Conference, Chicago, IL to be held in June 2001, and at the Snowmass Conference, CO, to be held on July 2001

  9. Enhancement of FEM radiation by prebunching of the e-beam (stimulated super-radiance)

    CERN Document Server

    Arbel, M; Kleinman, H; Yakover, I M; Abramovich, A; Pinhasi, Y; Luria, Y; Tecimer, M; Gover, A

    2001-01-01

    An electron beam (e-beam) prebunched at the synchronous FEM frequency and traversing through a waveguide, located coaxially with a magnetic undulator, emits coherent radiation at the bunching frequency. Introduction of both a premodulated e-beam and a radio-frequency (r.f.) signal at the same frequency at the input of the waveguide can lead to more efficient interaction, and thus more power can be extracted from the electron beam. In order to achieve this, the density modulation of the electron beam should be at an appropriate phase with respect to the r.f. signal. We report a first experimental demonstration of the influence of the phase difference between the r.f. input signal and the fundamental component of the density modulation of the e-beam on the radiated power in a Free-Electron Maser (FEM). Our experimental system allows control of the current density modulation, of the r.f. input power level, in the undulator region and of the phase between that r.f. input and the modulation of the e-beam. A compar...

  10. High-current CW beam profile monitors using transition radiation at CEBAF

    Science.gov (United States)

    Piot, P.; Denard, J.-C.; Adderley, P.; Capek, K.; Feldl, E.

    1997-01-01

    One way of measuring the profile of CEBAF's low-emittance, high-power beam is to use the optical transition radiation (OTR) emitted from a thin foil surface when the electron beam passes through it. We present the design of a monitor using the forward OTR emitted from a 0.25-μm carbon foil. We believe that the monitor will resolve three main issues: i) whether the maximum temperature of the foil stays below the melting point, ii) whether the beam loss remains below 0.5%, in order not to trigger the machine protection system, and iii) whether the monitor resolution (unlike that of synchrotron radiation monitors) is better than the product λγ. It seems that the most serious limitation for CEBAF is the beam loss due to beam scattering. We present results from Keil's theory and simulations from the computer code GEANT as well as measurements with aluminum foils with a 45-MeV electron beam. We also present a measurement of a 3.2-GeV beam profile that is much smaller than λγ, supporting Rule and Fiorito's calculations of the OTR resolution limit due to diffraction.

  11. Calculation of radiation attenuation coefficients, effective atomic numbers and electron densities for some building materials

    International Nuclear Information System (INIS)

    Some building materials, regularly used in Turkey, such as sand, cement, gas concrete (lightweight, aerated concrete), tile and brick, have been investigated in terms of mass attenuation coefficient, effective atomic, numbers (Zeff), effective electron densities (Ne) and photon interaction cross section (σa) at 14 different energies from 81- to 1332-keV gamma-ray energies. The gamma rays were detected by using gamma-ray spectroscopy, a High Purity Germanium (HPGe) detector. The elemental compositions of samples were analysed using an energy dispersive X-ray fluorescence spectrometer. Mass attenuation coefficients of these samples have been compared with tabulations based upon the results of WinXcom. The theoretical mass attenuation coefficients were estimated using the mixture rule and the experimental values of investigated parameters were compared with the calculated values. The agreement of measured values of mass attenuation coefficient, effective atomic numbers, effective electron densities and photon interaction cross section with the theory has been found to be quite satisfactory. (authors)

  12. Calculation of radiation attenuation coefficients, effective atomic numbers and electron densities for some building materials.

    Science.gov (United States)

    Damla, N; Baltas, H; Celik, A; Kiris, E; Cevik, U

    2012-07-01

    Some building materials, regularly used in Turkey, such as sand, cement, gas concrete (lightweight, aerated concrete), tile and brick, have been investigated in terms of mass attenuation coefficient (μ/ρ), effective atomic, numbers (Z(eff)), effective electron densities (N(e)) and photon interaction cross section (σ(a)) at 14 different energies from 81- to 1332-keV gamma-ray energies. The gamma rays were detected by using gamma-ray spectroscopy, a High Purity Germanium (HPGe) detector. The elemental compositions of samples were analysed using an energy dispersive X-ray fluorescence spectrometer. Mass attenuation coefficients of these samples have been compared with tabulations based upon the results of WinXcom. The theoretical mass attenuation coefficients were estimated using the mixture rule and the experimental values of investigated parameters were compared with the calculated values. The agreement of measured values of mass attenuation coefficient, effective atomic numbers, effective electron densities and photon interaction cross section with the theory has been found to be quite satisfactory. PMID:22128356

  13. Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

    LENUS (Irish Health Repository)

    Robb, W B

    2010-03-01

    The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine\\'s effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.

  14. Experimental and theoretical investigation of microwave and millimeter wave radiation from hollow, rotating, electron beams

    Science.gov (United States)

    Destler, W. W.; Weiler, R. L.; Striffler, C. D.

    1981-11-01

    During this period this effort has explored the scaling of the negative mass instability to regimes associated with smaller plasmas and short wavelengths for the plasma-produced radiation. An experimental apparatus for these studies is near completion. The nonlinear electromagnetic interaction between the collective/bunches of electrons and the radiation field has been formulated in an attempt to derive the efficiency of the production of radiation. In addition, the Dragon electron beam source is currently being improved for future radiation production experiments based on the negative mass instability. Experimental efforts at high powers have resulted in the enhancement of radiation at a single frequency. This last effort has utilized a "double-magnetron cavity' to enhance the radiation power in Ka band at 26 and 41GHz.

  15. Dosimetric Audits of Photon Beams in Radiation Therapy Centres

    International Nuclear Information System (INIS)

    Data related to eleven years of high-energy photon radiotherapy beams dosimetry are presented and analyzed. Dosimetric evaluations were carried out using water phantoms and thimble ionization chambers. Measurements were done at reference conditions for a standard absorbed dose of 100 cGy. The first dosimetry surveys from 1996 to 1998 showed deviations of 22% and 18.7%, although small deviations were also obtained. After 1998 the improvement of dosimetry quality control by the radiotherapy centers became clear, with most of the deviations situated within the ±3% range. (author)

  16. Design of a digital beam attenuation system for computed tomography. Part II. Performance study and initial results

    Energy Technology Data Exchange (ETDEWEB)

    Szczykutowicz, Timothy P. [Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705 (United States); Mistretta, Charles A. [Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705 (United States); Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, Madison, Wisconsin 53792 (United States); Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Drive, Madison, Wisconsin 53706 (United States)

    2013-02-15

    Purpose: The purpose of this work is to present a performance study of the digital beam attenuator (DBA) for implementing fluence field modulated CT (FFMCT) using a simulation framework developed to model the incorporation of the DBA into an existing CT system. Additionally, initial results will be presented using a prototype DBA and the realization of the prototype will be described. To our knowledge, this study represents the first experimental use of a device capable of modulating x-ray fluence as a function of fan angle using a CT geometry. Methods: To realize FFMCT, the authors propose to use a wedge design in which one wedge is held stationary and another wedge is moved over the stationary wedge. Due to the wedge shape, the composite thickness of the two wedges changes as a function of the amount of overlap between the wedges. This design allows for the wedges to modulate the photon fluence incident onto a patient. Using a simulation environment, the effect of changing the number of wedges has on dose, scatter, detector dynamic range, and noise uniformity is explored. Experimental results are presented using a prototype DBA having ten Fe wedges and a c-arm CT system geometry. The experimental DBA results are compared to non-DBA scans using scatter and detector dynamic range as metrics. Both flat field and bowtie filtered CT acquisitions were simulated for comparison with the DBA. Results: Numerical results suggest that substantial gains in noise uniformity and scatter-to-primary ratio (SPR) can be obtained using only seven wedges. After seven wedges, the decrease in noise ununiformity and SPR falls off at a lower rate. Simulations comparing CT acquisitions between flat field, bowtie enabled, and DBA CT acquisitions suggest DBA-FFMCT can reduce dose relative to flat field CT by Almost-Equal-To 3 times. A bowtie filter under the same imaging conditions was shown to only allow a dose reduction of 1.65 times. Experimentally, a 10 wedge DBA prototype result showed

  17. Separated high-energy electron beams using synchrotron radiation

    CERN Document Server

    Farley, F J M; Picasso, Emilio

    1972-01-01

    Electrons with kinetic energy in the 100 GeV range may be separated from other particles by using their energy-loss due to synchrotron radiation in a high-field magnet. In this paper the associated fluctuations in energy and angle are shown to be small enough for the method to be useful. Detailed design formulae are presented for several magnet configurations. (7 refs).

  18. Normal tissue tolerance to external beam radiation therapy: Skin

    International Nuclear Information System (INIS)

    Acute skin toxicity is frequent during radiation therapy and can lead to temporary arrest of the treatment. Chronic toxicity can occur and conduct to cosmetic problems. Alopecia is the most frequent toxicity concerning hair and is most of the time reversible. Several factors linked to patients influence skin toxicity, such as under-nutrition, old age, obesity, smoking, skin diseases, autoimmune diseases, failure of DNA reparation. Skin, hair and nail toxicities depend also on radiation schedule. Acute toxicity is greater when dose per fraction increases. Chronic and acute toxicities are more often when total dose increases. Under 45 Gy, the risk of severe skin toxicity is low, and begins above 50 Gy. Skin toxicity depends also on the duration of radiotherapy and split course schedules are associated with less toxicities. Irradiation surface seems to influence skin toxicity but interaction is more complex. Reirradiation is often feasible in case of cancer recurrence but with a risk of grade 3-4 toxicity above all in head and neck cancer. The benefit/risk ratio has to be always precisely evaluated. Permanent alopecia is correlated with the follicle dose. Modern techniques of radiation therapy allow to spare skin. (authors)

  19. Inferring phytoplankton carbon and eco-physiological rates from diel cycles of spectral particulate beam-attenuation coefficient

    Directory of Open Access Journals (Sweden)

    G. Dall'Olmo

    2011-11-01

    Full Text Available The diurnal fluctuations in solar irradiance impose a fundamental frequency on ocean biogeochemistry. Observations of the ocean carbon cycle at these frequencies are rare, but could be considerably expanded by measuring and interpreting the inherent optical properties. A method is presented to analyze diel cycles in particulate beam-attenuation coefficient (cp measured at multiple wavelengths. The method is based on fitting observations with a size-structured population model coupled to an optical model to infer the particle size distribution and physiologically relevant parameters of the cells responsible for the measured diel cycle in cp. Results show that the information related to size and contained in the spectral data can be exploited to independently estimate growth and loss rates during the day and night. In addition, the model can characterize the population of particles affecting the diel variability in cp. Application of this method to spectral cp measured at a station in the oligotrophic Mediterranean Sea suggests that most of the observed variations in cp can be ascribed to a synchronized population of cells with an equivalent spherical diameter around 4.6±1.5 μm. The inferred carbon biomass of these cells was about 5.2–6.0 mg m−3 and accounted for approximately 10% of the total particulate organic carbon. If successfully validated, this method may improve our in situ estimates of primary productivity.

  20. Inferring phytoplankton carbon and eco-physiological rates from diel cycles of spectral particulate beam-attenuation coefficient

    Directory of Open Access Journals (Sweden)

    G. Dall'Olmo

    2011-03-01

    Full Text Available The diurnal fluctuations in solar irradiance impose a fundamental frequency on ocean biogeochemistry. Observations of the ocean carbon cycle at these frequencies are rare, but could be considerably expanded by measuring and interpreting the inherent optical properties. A method is presented to analyze diel cycles in particulate beam-attenuation coefficient (cp measured at multiple wavelengths. The method is based on fitting observations with a size-structured population and optical model to infer the particle size distribution and physiologically relevant parameters of the cells responsible for the measured diel cycle in cp. Results show that the information related to size and contained in the spectral data can be exploited to independently estimate growth and loss rates during the day and night. In addition, the model can characterize the population of particles affecting the cp diel variability. Application of this method to spectral cp measured at a station in the oligotrophic Mediterranean Sea suggests that most of the observed variations in cp can be ascribed to a synchronized population of cells with an equivalent spherical diameter between 1 and 4 μm. The inferred carbon biomass of these cells was about 8–13 mg m−3 and accounted for approximately 20% of the total particulate organic carbon. If successfully validated and implemented on autonomous platforms, this method could improve our understanding of the ocean carbon cycle.

  1. Monsoon variability of ultraviolet radiation (UVR) attenuation and bio-optical factors in the Asian tropical coral-reef waters

    Science.gov (United States)

    Mizubayashi, Keiko; Kuwahara, Victor S.; Segaran, Thirukanthan C.; Zaleha, Kassim; Effendy, A. W. M.; Kushairi, M. R. M.; Toda, Tatsuki

    2013-07-01

    The East coast of Peninsular Malaysia is strongly influenced by the North-East (NE) monsoon, and may significantly influence the optical environment of coral-reef ecosystems. However, our knowledge of temporal variability, including episodic events, of environmental factors in Asian tropical regions is still limited. The objectives of this study were to (1) observe temporal variability in ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) attenuation and (2) determine the bio-optical factors regulating the optical environment in shallow coral-reef waters. Downwelling UVR and PAR irradiance and in situ bio-optical factors were measured monthly near Bidong Island on the East coast of Peninsular Malaysia from June 2010 to June 2011. The NE monsoon was recognized between November 2010 and January 2011. The highest diffuse attenuation coefficient at 305 nm was 2.05 ± 0.03 m-1 in a coral-reef area on December 2010. The most significant bio-optical factor at 305, 380, 440 nm during the NE monsoon season was CDOM (89 ± 8% at 305 nm, 84 ± 9% at 380 nm and 49 ± 17% at 440 nm). All UVR attenuation coefficients showed significant correlations with the CDOM absorption coefficients (aCDOM). CDOM with relatively low S275-295 during the NE monsoon season (0.0177 ± 0.0020 nm-1) suggests terrestrial sources, which is also supported by the correlation between salinity and aCDOM(305). A significant correlation between S275-295 and the carbon specific absorbance coefficient (a*(305)) suggest the potential to measure DOC optically in these waters. The high CDOM during the NE monsoon season may have an important role to reduce harmful UVR exposure reaching benthic communities.

  2. Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

    OpenAIRE

    Cho, Yu Ji; Yi, Chin Ok; Jeon, Byeong Tak; Jeong, Yi Yeong; Kang, Gi Mun; Lee, Jung Eun; Roh, Gu Seob; Lee, Jong Deog

    2013-01-01

    A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage acc...

  3. Nanoscale radiation transport and clinical beam modeling for gold nanoparticle dose enhanced radiotherapy (GNPT) using X-rays.

    Science.gov (United States)

    Zygmanski, Piotr; Sajo, Erno

    2016-01-01

    We review radiation transport and clinical beam modelling for gold nanoparticle dose-enhanced radiotherapy using X-rays. We focus on the nanoscale radiation transport and its relation to macroscopic dosimetry for monoenergetic and clinical beams. Among other aspects, we discuss Monte Carlo and deterministic methods and their applications to predicting dose enhancement using various metrics.

  4. Cherenkov imaging during volumetric modulated arc therapy for real-time radiation beam tracking and treatment response monitoring

    Science.gov (United States)

    Andreozzi, Jacqueline M.; Zhang, Rongxiao; Glaser, Adam K.; Gladstone, David J.; Jarvis, Lesley A.; Pogue, Brian W.

    2016-03-01

    External beam radiotherapy utilizes high energy radiation to target cancer with dynamic, patient-specific treatment plans. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high energy beam and tissue. Using a specialized camera-system, the Cherenkov emission can thus be used to track the radiation beam on the surface of the patient in real-time, even for complex cases such as volumetric modulated arc therapy (VMAT). Two patients undergoing VMAT of the head and neck were imaged and analyzed, and the viability of the system to provide clinical feedback was established.

  5. High-power beam-based coherently enhanced THz radiation source

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yuelin; /Argonne; Sun, Yin-E; /Argonne /Fermilab; Kim, Kwang-Je; /Argonne

    2008-08-01

    We propose a compact Smith-Purcell radiation device that can potentially generate high average power THz radiation with high conversion efficiency. The source is based on a train of short electron bunches from an rf photoemission gun at an energy of a few MeV. Particle tracking simulation and analysis show that, with a beam current of 1 mA, it is feasible to generate hundreds of watts of narrow-band THz radiation at a repetition rate of 1 MHz.

  6. Terahertz coherent transition radiation based on an ultrashort electron bunching beam

    Science.gov (United States)

    Liu, Wen-Xin; Huang, Wen-Hui; Du, Ying-Chao; Yan, Li-Xin; Wu, Dai; Tang, Chuan-Xiang

    2011-07-01

    The experimental result of terahertz (THz) coherent transition radiation generated from an ultrashort electron bunching beam is reported. During this experiment, the window for THz transmission from ultrahigh vacuum to free air is tested. The compact measurement system which can simultaneously test the THz wave power and frequency is built and proofed. With the help of improved Martin—Puplett interferometer and Kramers—Krong transform, the longitudinal bunch length is measured. The results show that the peak power of THz radiation wave is more than 80 kW, and its radiation frequency is from 0.1 THz to 1.5 THz.

  7. Ion beam induced charge and cathodoluminescence imaging of response uniformity of CVD diamond radiation detectors

    CERN Document Server

    Sellin, P J; Galbiati, A; Maghrabi, M; Townsend, P D

    2002-01-01

    The uniformity of response of CVD diamond radiation detectors produced from high quality diamond film, with crystallite dimensions of >100 mu m, has been studied using ion beam induced charge imaging. A micron-resolution scanning alpha particle beam was used to produce maps of pulse height response across the device. The detectors were fabricated with a single-sided coplanar electrode geometry to maximise their sensitivity to the surface region of the diamond film where the diamond crystallites are highly ordered. High resolution ion beam induced charge images of single crystallites were acquired that demonstrate variations in intra-crystallite charge transport and the termination of charge transport at the crystallite boundaries. Cathodoluminescence imaging of the same crystallites shows an inverse correlation between the density of radiative centres and regions of good charge transport.

  8. Development and application of a dosimetric methodology of therapeutic X radiation beams using a tandem system

    International Nuclear Information System (INIS)

    In radiotherapy the use of orthovoltage X radiation beams is still recommended; to obtain satisfactory results, a periodic control is necessary to check the performance of the ionization chambers and the radiation beams characteristics. This control is performed by using standard dosimetric procedures, as for example the determination of half-value layers and the absorbed dose rates. A Tandem system was established in this work using a pair of ionization chambers (a thimble type and a superficial type) used for measures in a medical institution, in substitution to the routine conventional procedure of determination of half-value layers using absorbers. The results obtained show the application of this method in dosimetric procedures of orthovoltage beams (radiotherapy) as a complement for a quality control program. (author)

  9. A novel method involving Matlab coding to determine the distribution of a collimated ionizing radiation beam

    Science.gov (United States)

    Ioan, M.-R.

    2016-08-01

    In ionizing radiation related experiments, precisely knowing of the involved parameters it is a very important task. Some of these experiments are involving the use of electromagnetic ionizing radiation such are gamma rays and X rays, others make use of energetic charged or not charged small dimensions particles such are protons, electrons, neutrons and even, in other cases, larger accelerated particles such are helium or deuterium nuclei are used. In all these cases the beam used to hit an exposed target must be previously collimated and precisely characterized. In this paper, a novel method to determine the distribution of the collimated beam involving Matlab coding is proposed. The method was implemented by using of some Pyrex glass test samples placed in the beam where its distribution and dimension must be determined, followed by taking high quality pictures of them and then by digital processing the resulted images. By this method, information regarding the doses absorbed in the exposed samples volume are obtained too.

  10. Study of filamentation dynamics of ultrashort laser radiation in air: beam diameter effect

    International Nuclear Information System (INIS)

    A single filamentation of femtosecond gigawatt laser radiation with a millimeter-size aperture upon collimated and sharply focused propagation in atmospheric air at 800 nm and 400 nm wavelengths is studied both theoretically and experimentally. The influence of beam initial radius on the parameters of the forming filament is analyzed. Three filament parameters, namely, start coordinate, filament length, and longitudinal continuity are considered. We report that unlike Marburger’s formula the single filamentation onset reveals marked nonquadratic dependence on the laser beam radius providing the same initial pulse power. Additionally, for sharply focused radiation the minor dependence of the filament length on the laser beam diameter at the constant initial pulse intensity was experimentally revealed. (paper)

  11. Photon beam audits for radiation therapy clinics: A pilot mailed dosemeter study in Turkey

    International Nuclear Information System (INIS)

    A thermoluminescent dosemeter (TLD) mailed dose audit programme was performed at five radiotherapy clinics in Turkey. The intercomparison was organised by the Univ. of Wisconsin Radiation Calibration Laboratory (UWRCL), which was responsible for the technical aspects of the study including reference irradiations, distribution, collection and evaluation. The purpose of these audits was to perform an independent dosimetry check of the radiation beams using TLDs sent by mail. Acrylic holders, each with five TLD chips inside and instructions for their irradiation to specified absorbed dose to water of 2 Gy, were mailed to all participating clinics. TLD irradiations were performed with a 6 MV linear accelerator and 60Co photon beams. The deviations from the TL readings of UWRCL were calculated. Discrepancies inside the limits of ±5 % between the participant-stated dose, and the TLD-measured dose were considered acceptable. One out of 10 beams checked was outside this limit, with a difference of 5.8 %. (authors)

  12. Poster — Thur Eve — 18: Cherenkov Emission By High-Energy Radiation Therapy Beams: A Characterization Study

    Energy Technology Data Exchange (ETDEWEB)

    Zlateva, Y.; El Naqa, I. [Medical Physics Unit, Department of Oncology, McGill University, Montreal, QC (Canada); Quitoriano, N. [Department of Mining and Materials Engineering McGill University, Montreal, QC (Canada)

    2014-08-15

    We investigate Cherenkov emission (CE) by radiotherapy beams via radiation dose-versus-CE correlation analyses, CE detection optimization by means of a spectral shift towards the near-infrared (NIR) window of biological tissue, and comparison of CE to on-board MV imaging. Dose-CE correlation was investigated via simulation and experiment. A Monte Carlo (MC) CE simulator was designed using Geant4. Experimental phantoms include: water; tissue-simulating phantom composed of water, Intralipid®, and beef blood; plastic phantom with solid water insert. The detector system comprises an optical fiber and diffraction-grating spectrometer incorporating a front/back-illuminated CCD. The NIR shift was carried out with CdSe/ZnS quantum dots (QDs), emitting at (650±10) nm. CE and MV images were acquired with a CMOS camera and electronic portal imaging device. MC and experimental studies indicate a strong linear dose-CE correlation (Pearson coefficient > 0.99). CE by an 18-MeV beam was effectively NIR-shifted in water and a tissue-simulating phantom, exhibiting a significant increase at 650 nm for QD depths up to 10 mm. CE images exhibited relative contrast superior to MV images by a factor of 30. Our work supports the potential for application of CE in radiotherapy online imaging for patient setup and treatment verification, since CE is intrinsic to the beam and non-ionizing and QDs can be used to improve CE detectability, potentially yielding image quality superior to MV imaging for the case of low-density-variability, low-optical-attenuation materials (ex: breast/oropharynx). Ongoing work involves microenvironment functionalization of QDs and application of multi-channel spectrometry for simultaneous acquisition of dosimetric and tumor oxygenation signals.

  13. The Performance of the Beam Conditions and Radiation Monitoring System of CMS

    CERN Document Server

    Dabrowski, Anne

    2011-01-01

    The Beam Conditions and Radiation Monitoring System (BRM), is installed in CMS to protect the CMS detector from high beam losses and to provide feedback to the LHC and CMS on the beam conditions. The primary detector sub-systems are based on either single crystal diamond sensors (BCM1F) for particle counting with nanosecond resolution or on polycrystalline diamonds (BCM2; BCM1L) for integrated signal current measurements. Beam scintillation counters (BSC) are also used during low luminosity running. The detectors have radiation hard front-end electronics and are read out independently of the CMS central data acquisition and are online whenever there is beam in the LHC machine. The various sub-systems exploit different time resolutions and position locations to be able to monitor the beam induced backgrounds and the flux of particles produced during collisions. This paper describes the CMS BRM system and the complementary aspects of the installed BRM sub-detectors to measure both single particle count rates a...

  14. External beam radiation for retinoblastoma: Results, patterns of failure, and a proposal for treatment guidelines

    International Nuclear Information System (INIS)

    Purpose: To analyze treatment results and patterns of failure following external beam radiation for retinoblastoma and propose treatment guidelines according to specific clinical variables. Methods and Materials: We analyzed 27 patients (34 eyes) with retinoblastoma who received external beam radiation as initial treatment at Hahnemann University Hospital from October 1980 to December 1991 and have been followed for at least 1 year. Of the 34 eyes, 14 were Groups I-II (Reese-Ellsworth classification), 7 were Group III, and 13 were Groups IV-V. Doses ranged from 34.5-49.5 Gy (mean 44.3 Gy, median 45 Gy) in 1.5-2.0 Gy fractions generally delivered through anterior and lateral wedged pair fields. Results: At a mean follow up of 35.2 months (range 12-93 months), local tumor control was obtained in 44% (15 out of 34) of eyes with external beam radiation alone. Salvage therapy (plaque brachytherapy, cryotherapy, and/or photocoagulation) controlled an additional 10 eyes (29.5%), so that overall ocular survival has been 73.5%. Local tumor control with external beam radiotherapy alone was obtained in 78.5% (11 out of 14) of eyes in Groups I-II, but in only 20% (4 out of 20) of eyes in Groups III-V. A total of 67 existing tumors were identified prior to treatment in the 34 treated eyes and local control with external beam radiation alone was obtained in 87% (46 out of 53) of tumors measuring 15 mm or less and in 50% (7 out of 14) of tumors measuring more than 15 mm. When analyzing patterns of failure in the 19 eyes that relapsed, a total of 28 failure sites were identified and consisted of progression of vitreous seeds in seven instances (25% of failure sites) recurrences from previously existing tumors in 10 instances (36% of failure sites) and development of new tumors in previously uninvolved retina in 11 instances (39% of failure sites). Conclusions: 1) We find that external beam radiation to a dose of 45 Gy in fractions of 1.5 to 2.0 Gy provides adequate tumor control

  15. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    Energy Technology Data Exchange (ETDEWEB)

    Kosunen, A

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?){sup water} {sub air}, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in {sup 60}Co gamma beams. In photon beam dosimetry (S I ?){sup water} {sub air} can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation

  16. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    International Nuclear Information System (INIS)

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?)waterair, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in 60Co gamma beams. In photon beam dosimetry (S I ?)waterair can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation). To improve the accuracy of

  17. Efficient, radiation-hardened, 800-keV neutral beam injection system

    International Nuclear Information System (INIS)

    Recent advances and new concepts in negative ion generation, transport, acceleration, and neutrailzation make it appear likely that an efficient, radiation-hardened neutral beam injection system could be developed in time for the proposed FED-A tokamak. These new developments include the operation of steady-state H- ion sources at over 5 A per meter of source length, the concept of using strong-focussing electrostatic structures for low-gradient dc acceleration of high-current sheet beams of negative ions and the transport of these beams around corners, and the development of powerful oxygen-iodine chemical lasers which will make possible the efficient conversion of the negative ions to neutrals using a photodetachment scheme in which the ion beam passes through the laser cavity

  18. Electromagnetic Coupling Between High Intensity LHC Beams and the Synchrotron Radiation Monitor Light Extraction System

    CERN Document Server

    Andreazza, W; Bravin, E; Caspers, F; Garlasch`e, M; Gras, J; Goldblatt, A; Lefevre, T; Jones, R; Metral, E; Nosych, A; Roncarolo_, F; Salvant, B; Trad, G; Veness, R; Vollinger, C; Wendt, M

    2013-01-01

    The CERN LHC is equipped with two Synchrotron Radiation Monitor (BSRT) systems used to characterise transverse and longitudinal beam distributions. Since the end of the 2011 LHC run the light extraction system, based on a retractable mirror, has suffered deformation and mechanical failure that is correlated to the increase in beam intensity. Temperature probes have associated these observations to a strong heating of the mirror support with a dependence on the longitudinal bunch length and shape, indicating the origin as electromagnetic coupling between the beam and the structure. This paper combines all this information with the aim of characterising and improving the system in view of its upgrade during the current LHC shutdown. Beam-based observations are presented along with electromagnetic and thermomechanical simulations and complemented by laboratory measurements, including the study of the RF properties of different mirror bulk and coating materials.

  19. Time-Resolved Emittance Characterization of an Induction Linac Beam using Optical Transition Radiation

    CERN Document Server

    Le Sage, G P

    2002-01-01

    An induction linac is used by Lawrence Livermore National Laboratory to perform radiographic testing at the Flash X-ray Radiography facility. Emittance characterization is important since x-ray spot size impacts the resolution of shadow-graphs. Due to the long pulse length, high current, and beam energy, emittance measurement using Optical Transition Radiation is an attractive alternative for reasons that will be described in the text. The utility of OTR-based emittance measurement has been well demonstrated for both RF and induction linacs. We describe the time-resolved emittance characterization of an induction linac electron beam. We have refined the optical collection system for the induction linac application, and have demonstrated a new technique for probing the divergence of a subset of the beam profile. The experimental apparatus, data reduction, and conclusions will be presented. Additionally, a new scheme for characterizing the correlation between beam divergence and spatial coordinates within the b...

  20. Influence of Vertical Attenuation of Photosynthetically Active Radiation on the Growth of Submerged Aquatic Vegetation in Tropical Reservoir.

    Science.gov (United States)

    da Silva Rotta, L. H.; Mishra, D. R.; Alcântara, E. H.; Imai, N. N.

    2015-12-01

    Reservoir construction cause many changes in lotic ecosystems and can favor the aquatic macrophyte growth. Nova Avanhandava Reservoir (São Paulo, Brazil), is fully inhabited by submerged aquatic vegetation (SAV) which may cause serious problems to hydropower and irrigation systems. The goal of this study was to assess the radiation availability in the water column in Nova Avanhandava and analyze its influence on SAV development and growth. The measurements were carried out between 28th and 30th June, 2013, at 19 sampling stations. Water samples for analytical determination of the suspended solids and chlorophyll-a concentration were collected. Hyperspectral downwelling irradiance (Ed) data, at several depths, were measured using the TriOS/RAMSES optical sensor. Depths and SAV heights were collected through hydroacoustic measurements by transects using the scientific digital sonar BioSonics DT-X (Echosounder). The Ed data were normalized, than calculated the Kd PAR - downwelling diffuse attenuation coefficient of photosynthetically active radiation, and the euphotic zone depth (ZEZ). Results showed that SAV height values were lower at upstream (around P01) with highest TSS (Total Suspended Solids) and Kd, compared to areas downstream (around P19) (Figure). The maximum depth of SAV development, average SAV height, maximum SAV height, variability, and depth of occurrence of SAV were primarily influenced by Kd. A linear inverse relationship between the average SAV height and the Kd PAR (R2 = 0.56, p<0.001), and between maximum SAV height and Kd PAR (R²=0.5, p<0.001) demonstrated that the SAV heigth can be estimated by Kd PAR with significant accuracy. Therefore, studies on subaquatic radiation availability measured by the vertical attenuation of Ed PAR in the water column and the optically active components can be effiectivly linked to SAV growth and occurrence and aid in understanding SAV in tropical reservoirs, contributing to its management.

  1. Attenuation of an ultrasonic beam by suspended particles and range of acoustic flow meters in sewer networks.

    Science.gov (United States)

    Larrarte, Frédérique; François, Pierre

    2012-01-01

    Ultrasonic flow meters are commonly used in wastewater management. Under certain circumstances, a reduction in the flow meter range may occur and cause significant error in the flow rate measurement. Attenuation due to suspended particles is one of the phenomena capable of reducing the flow meter range. The present paper examines attenuation resulting from re-suspended pond sediment over a wide range of concentration values. It appears that a formula established for sand suspensions provides a good estimate of ultrasound attenuation for these types of particles as well. Experiments conducted for wastewater under particle concentrations commonly encountered in sewer networks demonstrate that the attenuation by particles only contributes to a negligible extent towards intensity decay, in accordance with theoretical predictions. We also theoretically determine herein the operating conditions under which the range of an ultrasonic flow meter would be significantly reduced due to particle attenuation. PMID:22258678

  2. Effect of electron-beam radiation on graphite epoxy composites

    International Nuclear Information System (INIS)

    Specimens of unidirectional graphite/epoxy laminates were irradiated by 10-MeV electrons up to a total dose of 5000 Mrads at 50, 150, and 250 C and then tested mechanically to determine their flexural and interlaminar shear strengths. The radiation-generated volatile products and the components extracted by a solvent from the irradiated specimens were analyzed by gas-chromatographic and mass spectrometric techniques; the degradation of the matrix resin (bisphenol based epoxy) was characterized by FT-IR spectroscopy. It is found that the flexural strength of the specimens irradiated in air decreases with increasing dose. The flexural strength of the irradiated specimens, however, can be almost completely restored through a thermal cycling treatment. It is also shown that the degradation of the matrix increases with the irradiation dose. 9 references

  3. Development of monoenergetic electron beam sources for radiation-instrument calibration

    Science.gov (United States)

    Soares, C. G.; Dick, C. E.; Pruitt, J. S.; Sparrow, J. H.

    1985-05-01

    Accelerator-produced electron beams are being studied for use in obtaining the response of beta-particle dosimetry instrumenta- tion as a function of electron energy. The NBS 4 MV Van de Graaff and 500 kV cascaded rectifier accelerators are being used to generate electron beams from 200 keV to 2.5 MeV. A device capable of scanning the electron beam in two dimensions over an area large enough to cover radiation-survey instruments uniformly is attached to the beam-handling system of each accelerator. The scanned beam exits from vacuum through a 16 cm 2 window consisting of either 25 μm Kapton (for energies below 500 keV) or 100 μm aluminum. The electron beams produced have been characterized in terms of (1) spatial distribution, (2) energy spectrum, and (3) absorbed dose to plastic. Spatial distributions were determined using film, while spectra were measured using a 5 mm-deep Si surface barrier detector. An extrapolation chamber is being used for beam standardization in terms of absorbed dose to plastic.

  4. Development of monoenergetic electron beam sources for radiation-instrument calibration

    Energy Technology Data Exchange (ETDEWEB)

    Soares, C.G.; Dick, C.E.; Pruitt, J.S.; Sparrow, J.H.

    1985-05-15

    Accelerator-produced electron beams are being studied for use in obtaining the response of beta-particle dosimetry instrumentation as a function of electron energy. The NBS 4 MV Van de Graaff and 500 kV cascaded rectifier accelerators are being used to generate electron beams from 200 keV to 2.5 MeV. A device capable of scanning the electron beam in two dimensions over an area large enough to cover radiation-survey instruments uniformly is attached to the beam-handling system of each accelerator. The scanned beam exits from vacuum through a 16 cm/sup 2/ window consisting of either 25 ..mu..m Kapton (for energies below 500 keV) or 100 ..mu..m aluminum. The electron beams produced have been characterized in terms of (1) spatial distribution, (2) energy spectrum, and (3) absorbed dose to plastic. Spatial distributions were determined using film, while spectra were measured using a 5 mm-deep Si surface barrier detector. An extrapolation chamber is being used for beam standardization in terms of absorbed dose to plastic. (orig.).

  5. Radiation and Background Levels in a CLIC Detector due to Beam-Beam Effects Optimisation of Detector Geometries and Technologies

    CERN Document Server

    Sailer, André; Lohse, Thomas

    2013-01-10

    The high charge density---due to small beam sizes---and the high energy of the proposed CLIC concept for a linear electron--positron collider with a centre-of-mass energy of up to 3~TeV lead to the production of a large number of particles through beam-beam interactions at the interaction point during every bunch crossing (BX). A large fraction of these particles safely leaves the detector. A still significant amount of energy will be deposited in the forward region nonetheless, which will produce secondary particles able to cause background in the detector. Furthermore, some particles will be created with large polar angles and directly cause background in the tracking detectors and calorimeters. The main sources of background in the detector, either directly or indirectly, are the incoherent $mathrm{e}^{+}mathrm{e}^{-}$ pairs and the particles from $gammagamma ightarrow$ hadron events. The background and radiation levels in the detector have to be estimated, to study if a detector is feasible, that can han...

  6. The Role of Beam polarization for Radiative Neutralino Production at the ILC

    CERN Document Server

    Dreiner, H K; Langenfeld, U; Dreiner, Herbert K.; Kittel, Olaf; Langenfeld, Ulrich

    2007-01-01

    We analyze the impact of electron and positron beam polarization on radiative neutralino production at the International Linear Collider (ILC). We focus on three different mSUGRA scenarios in turn at the Higgs strahlung threshold, the top pair production threshold, and at $\\sqrt{s} =500\\GeV$. In these scenarios at the corresponding $\\sqrt{s}$, radiative neutralino production is the only supersymmetric production mechanism which is kinematically allowed. The heavier neutralinos, and charginos as well as the sleptons, squarks and gluinos are too heavy to be pair produced. We calculate the signal cross section and also the Standard Model background from radiative neutrino production. For our scenarios, we obtain significances larger than 10 and signal to background ratios between 2% and 5%, if we have electron beam polarization $P_{e^-} = 0.0- 0.8$ and positron beam polarization $P_{e^+} = 0.0 - 0.3$. If we have electron beam polarization of $P_{e^-} = 0.9$, then the signal is observable with $P_{e^+} = 0.0$ but...

  7. Cooling of relativistic electron beams in intense laser pulses: Chirps and radiation

    Science.gov (United States)

    Yoffe, S. R.; Noble, A.; Macleod, A. J.; Jaroszynski, D. A.

    2016-09-01

    Next-generation high-power laser facilities (such as the Extreme Light Infrastructure) will provide unprecedented field intensities, and will allow us to probe qualitatively new physical regimes for the first time. One of the important fundamental questions which will be addressed is particle dynamics when radiation reaction and quantum effects play a significant role. Classical theories of radiation reaction predict beam cooling in the interaction of a relativistic electron bunch and a high-intensity laser pulse, with final-state properties only dependent on the laser fluence. The observed quantum suppression of this cooling instead exhibits a dependence on the laser intensity directly. This offers the potential for final-state properties to be modified or even controlled by tailoring the intensity profile of the laser pulse. In addition to beam properties, quantum effects will be manifest in the emitted radiation spectra, which could be manipulated for use as radiation sources. We compare predictions made by classical, quasi-classical and stochastic theories of radiation reaction, and investigate the influence of chirped laser pulses on the observed radiation spectra.

  8. Integrating and automating the software environment for the Beam and Radiation Monitoring for CMS

    CERN Document Server

    Filyushkina, Olga; Juslin, J

    2010-01-01

    The real-time online visualization framework used by the Beam and Radiation Monitoring group at the Compact Muon Solenoid at Large Hadron Collider, CERN. The purpose of the visualization framework is to provide real-time diagnostic of beam conditions, which defines the set of the requirements to be met by the framework. Those requirements include data quality assurance, vital safety issues, low latency, data caching, etc. The real-time visualization framework is written in the Java programming language and based on JDataViewer--a plotting package developed at CERN. At the current time the framework is run by the Beam and Radiation Monitoring, Pixel, Tracker groups, Run Field Manager and others. It contributed to real-time data analysis during 2009-2010 runs as a stable monitoring tool. The displays reflect the beam conditions in a real-time with the low latency level, thus it is the first place at the CMS detector where the beam collisions are observed.

  9. Radiation optic neuropathy after external beam radiation therapy for acromegaly : report of two cases

    NARCIS (Netherlands)

    van den Bergh, ACM; Hoving, MA; Links, TP; Dullaart, RPF; Ranchor, AV; ter Weeme, CA; Canrinus, AA; Szabo, BG; Pott, JWR

    2003-01-01

    For diagnosing radiation optic neuropathy (RON) ophthalmological and imaging data were evaluated from 63 acromegalic patients, irradiated between 1967 and 1998. Two patients developed RON: one patient in one optic nerve 10 years and another patient in both optic nerves 5 months after radiation thera

  10. A novel method for sub-micrometer transverse electron beam size measurements using optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Aryshev, A; Boogert, S T; Karataev, P [John Adams Institute at Royal Holloway, Egham, Surrey, TW20 0EX (United Kingdom); Howell, D [John Adams Institute at Oxford University, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Terunuma, N; Urakawa, J, E-mail: alar@post.kek.j [KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2010-06-01

    Optical Transition Radiation (OTR) appearing when a charged particle crosses a boundary between two media with different dielectric properties has widely been used as a tool for transverse profile measurements of charged particle beams in various facilities worldwide. The resolution of the monitor is defined by so-called Point Spread Function (PSF), source distribution generated by a single electron and projected by an optical system onto a screen. In this paper we represent the development of a novel sub-micrometre electron beam profile monitor based on the measurements of the PSF structure. The first experimental results are presented and future plans on the optimization of the monitor are discussed

  11. Determination of the LEP Beam Energy using Radiative Fermion-pair Events, 2004

    CERN Document Server

    Abbiendi, G; Åkesson, P F; Alexander, G; Allison, J; Amaral, P; Anagnostou, G; Anderson, K J; Asai, S; Axen, D A; Bailey, I; Barberio, E; Barillari, T; Barlow, R J; Batley, J Richard; Bechtle, P; Behnke, T; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bethke, Siegfried; Biebel, O; Boeriu, O; Bock, P; Boutemeur, M; Braibant, S; Brown, R M; Burckhart, H J; Campana, S; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Ciocca, C; Csilling, A; Cuffiani, M; Dado, S; de Roeck, A; De Wolf, E A; Desch, Klaus; Dienes, B; Donkers, M; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Etzion, E; Fabbri, Franco Luigi; Ferrari, P; Fiedler, F; Fleck, I; Ford, M; Frey, A; Gagnon, P; Gary, J W; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Giunta, M; Goldberg, J; Gross, E; Grunhaus, Jacob; Gruwé, M; Günther, P O; Sen-Gupta, A; Hajdu, C; Hamann, M; Hanson, G G; Harel, A; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, R J; Herten, G; Heuer, R D; Hill, J C; Hoffman, K; Horváth, D; Igo-Kemenes, P; Ishii, K; Jeremie, H; Jovanovic, P; Junk, T R; Kanzaki, J; Karlen, Dean A; Kawagoe, K; Kawamoto, T; Keeler, R K; Kellogg, R G; Kennedy, B W; Kluth, S; Kobayashi, T; Kobel, M; Komamiya, S; Kramer, T; Krieger, P; Von Krogh, J; Kühl, T; Kupper, M; Lafferty, G D; Landsman, Hagar Yaël; Lanske, D; Lellouch, D; Letts, J; Levinson, L; Lillich, J; Lloyd, S L; Loebinger, F K; Lü, J; Ludwig, A; Ludwig, J; Mader, W; Marcellini, S; Martin, A J; Masetti, G; Mashimo, T; Mättig, P; McKenna, J A; McPherson, R A; Meijers, F; Menges, W; Merritt, F S; Mes, H; Meyer, N; Michelini, A; Mihara, S; Mikenberg, G; Miller, D J; Mohr, W; Mori, T; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nisius, R; O'Neale, S W; Oh, A; Oreglia, M J; Orito, S; Pahl, C; Pásztor, G; Pater, J R; Pilcher, J E; Pinfold, J L; Plane, D E; Pooth, O; Przybycien, M B; Quadt, A; Rabbertz, K; Rembser, C; Renkel, P; Roney, J M; Rossi, A M; Rozen, Y; Runge, K; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Schaile, A D; Schaile, O; Scharff-Hansen, P; Schieck, J; Schörner-Sadenius, T; Schröder, M; Schumacher, M; Seuster, R; Shears, T G; Shen, B C; Sherwood, P; Skuja, A; Smith, A M; Sobie, R J; Söldner-Rembold, S; Spanó, F; Stahl, A; Strom, D; Ströhmer, R; Tarem, S; Tasevsky, M; Teuscher, R; Thomson, M A; Torrence, E; Toya, D; Tran, P; Trigger, I; Trócsányi, Z L; Tsur, E; Turner-Watson, M F; Ueda, I; Ujvári, B; Vollmer, C F; Vannerem, P; Vertesi, R; Verzocchi, M; Voss, H; Vossebeld, Joost Herman; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wengler, T; Wermes, N; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Zer-Zion, D; Zivkovic, L

    2004-01-01

    We present a determination of the LEP beam energy using "radiative return" fermion-pair events recorded at centre-of-mass energies from 183 GeV to 209 GeV. We find no evidence of a disagreement between the OPAL data and the LEP Energy Workings Group's standard calibration. Including the energy- averaged 11 MeV uncertainty in the standard determination, the beam energy we obtain from the OPAL data is higher than that obtained from the LEP calibration by 0+-34(stat.)+-27(syst.)MeV

  12. Radiative corrections to chargino production in electron-positron collisions with polarized beams

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, Marco A.; King, Stephen F.; Ross, Douglas A.

    2001-07-01

    We study radiative corrections to chargino production at linear colliders with polarized electron beams. We calculate the one-loop corrected cross sections for polarized electon beams due to three families of quarks and squarks, working in the {ovr MS} scheme, extending our previous calculation of the unpolarized cross section with one-loop corrections due to the third family of quarks and squarks. In some cases we find rather large corrections to the tree-level cross sections. For example, for the case of right-handed polarized electrons and large tan{beta} the corrections can be of order 30%, allowing sensitivity to the squark mass parameters.

  13. Role of the rise rate of beam current in the microwave radiation of vircator

    Science.gov (United States)

    Li, Limin; Cheng, Guoxin; Zhang, Le; Ji, Xiang; Chang, Lei; Xu, Qifu; Liu, Lie; Wen, Jianchun; Li, Chuanlu; Wan, Hong

    2011-04-01

    In this paper, the effect of the rise rate of beam current on the microwave radiation of a virtual cathode oscillator (vircator) is presented. Interestingly, it was observed that the rise rate of the beam current increased as the pulse shot proceeded, which is accompanied by the decrease in microwave power. By comparing the experimental results of two cathode materials (carbon fiber and stainless steel), it was found that the above behavior is independent of the cathode materials. The ion flow, induced by the repetitive action of beam electrons with the anode grid, directly affects the development of beam current. A twice-increased process of ion flow was observed, and there are two factors involved in this process, namely, the reflection of electrons between the cathode and virtual cathode and the effect of one-time bombardment of electron beam. After the irradiation of pulsed electron beam, some microprotrusions toward the cathode appeared on the anode surface, with a quasiperiodic structure. The appearance of ion flow, as the anode plasma forms, increases the beam current and enhances the beam current density. The anode plasma is generated relatively easily as the shot test proceeds, due to the aging of anode grid, which allows the possibility of the decrease in the microwave power. As the pulse shot proceeds, the changes in the rise rate of beam current are closely related to the aging process of anode surface. Therefore, the further enhancement of vircator efficiency needs to lengthen the lifetime of anode, besides the optimization of explosive emission cathodes.

  14. Gracilaria bursa-pastoris (Gmelin) Silva extract attenuates ultraviolet B radiation-induced oxidative stress in human keratinocytes.

    Science.gov (United States)

    Piao, M J; Kim, K C; Zheng, J; Yao, C W; Cha, J W; Kang, H K; Yoo, E S; Koh, Y S; Ko, M H; Lee, N H; Hyun, Jin Won

    2014-01-01

    The purpose of this study was to assess the protective effects of an ethanol extract derived from the red alga Gracilaria bursa-pastoris (Gmelin) Silva (GBE) on ultraviolet B (UVB)-irradiated human HaCaT keratinocytes. GBE exhibited scavenging activity against intracellular reactive oxygen species that were induced by either hydrogen peroxide or UVB radiation. In addition, both the superoxide anion and the hydroxyl radical were scavenged by GBE in cell-free systems. GBE absorbed light in the UVB range (280-320 nm) of the electromagnetic spectrum and lessened the extent of UVB-induced oxidative damage to cellular lipids, proteins, and DNA. Finally, GBE-treated keratinocytes showed a reduction in UVB-induced apoptosis, as exemplified by fewer apoptotic bodies. These results suggest that GBE exerts cytoprotective actions against UVB-stimulated oxidative stress by scavenging ROS and absorbing UVB rays, thereby attenuating injury to cellular constituents and preventing cell death.

  15. Why the radiation-attenuated cercarial immunization studies failed to guide the road for an effective schistosomiasis vaccine: A review

    Directory of Open Access Journals (Sweden)

    Rashika El Ridi

    2015-05-01

    Full Text Available Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to 90% was achieved, providing a sound proof that vaccination against this infection is feasible. Extensive histopathological, tissue mincing and incubation, autoradiographic tracking, parasitological, and immunological studies led to defining conditions and settings for achieving optimal protection and delineating the resistance underlying mechanisms. The present review aims to summarize these findings and draw the lessons that should have guided the development of an effective schistosomiasis vaccine.

  16. Why the radiation-attenuated cercarial immunization studies failed to guide the road for an effective schistosomiasis vaccine: A review.

    Science.gov (United States)

    El Ridi, Rashika; Tallima, Hatem

    2015-05-01

    Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to 90% was achieved, providing a sound proof that vaccination against this infection is feasible. Extensive histopathological, tissue mincing and incubation, autoradiographic tracking, parasitological, and immunological studies led to defining conditions and settings for achieving optimal protection and delineating the resistance underlying mechanisms. The present review aims to summarize these findings and draw the lessons that should have guided the development of an effective schistosomiasis vaccine. PMID:26257924

  17. Radiation-induced transient attenuation of optical fibers at 800 and 1300 nm

    International Nuclear Information System (INIS)

    Radiation-induced absorption in optical fibers has been a subject of considerable interest throughout the world. As availability and applications of fibers have evolved from ''first window'' systems operating near 850 nm to ''second window'' systems near 1300 nm, interest in wavelength dependence of radiation effects in optical fibers has similarly evolved. The present work summarizes second-window, radiation-induced transient absorption measurements in optical fibers for times shorter than 5 μs. Comparisons to first window data for these fibers are also presented. Only high purity silica fibers with low-OH concentrations were used in the present study to avoid the large OH absorption band in this region. This paper also collects first window data on several high-OH optical fibers

  18. Irradiation of 135 MeV/u carbon and neon beams for studies of radiation biology

    International Nuclear Information System (INIS)

    A heavy ion irradiation system was designed and constructed at RIKEN ring cyclotron facility for studies of radiation physics and radiation biology. Carbon and neon beams of 135 MeV/u were firstly used for the experiments. A pair of wobbler magnets and a scatterer were used for obtaining the uniform radiation field of about 10 cm in diameter. A parallel plate ionization chamber was used for dose monitoring. A range shifter was used for degrading the initial energy of the heavy ions. Precise depth dose distributions were measured by a small parallel plate ionization chamber and a variable length water column. LET (linear energy transfer) of the heavy ion radiation fields were measured by a parallel plate proportional chamber. From these basic measurements, biological experiments using these heavy ions are now carried out at this facility. (author)

  19. An examination of human factors in external beam radiation therapy: Findings and implications

    International Nuclear Information System (INIS)

    To better understand the contributing factors to human error in external beam radiation therapy, the US Nuclear Regulatory Commission has undertaken a series of human factors evaluations. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted visits to 24 radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of human-system interfaces, procedures, training and qualifications, and organizational policies and practices. Representative findings and implications for improvement are discussed within the context of a dynamic model which holds that misadministration likely results from the unanticipated interaction of several necessary but singly insufficient conditions

  20. CMS Run-2 Instrumentation for beam radiation and luminosity measurement using novel detector technologies

    Science.gov (United States)

    Gomez Espinosa, Alejandro; CMS Collaboration Collaboration

    2016-03-01

    The higher energy and luminosity for Run 2 at the LHC initiated the development of dedicated technologies for beam radiation monitoring and luminosity measurement. A dedicated pixel luminosity detector measures coincidences in several three layer telescopes of silicon pixel detectors to arrive at a luminosity for each colliding LHC bunch pair. The full pixel data is also read out at a lower rate to reconstruct charged particle tracks for monitoring and beam spot determination. The upgraded fast beam conditions monitor measures the particle flux using 24 two pad single crystalline diamond sensors, equipped with a fast front-end ASIC, produced in 130 nm CMOS technology, for excellent time resolution. A new beam-halo monitor exploits Cerenkov light production in fused quartz crystals to provide direction sensitivity and excellent time resolution to separate incoming and outgoing particles. The back-end electronics of the beam monitoring systems include dedicated modules with high bandwidth digitizers developed in both VME and microTCA standards for per bunch beam measurements and gain monitoring. All sub-detectors have been taking data from the first day of LHC operation in April 2015. Detector performance results from the 2015 LHC Run II will be presented.

  1. Physical conditions for sources radiating a cosh-Gaussian model beam

    Institute of Scientific and Technical Information of China (English)

    LI Jia

    2011-01-01

    Based on the coherence theory of diffracted optical field and the model for partially coherent beams, analytical expressions for the cross-spectral density and the irradiance spectral density in the far zone are derived, respectively. Utilizing the theoretical model of radiation from secondary planar sources, the physical conditions for sources generating a cosh-Gaussian (CHG) beam are investigated. Analytical results demonstrate that the parametric conditions strongly depend on the coherence property of sources. When almost coherence property is satisfied in the source plane, the conditions are the same as those for fundamental Gaussian beams; when partial coherence or almost incoherence property is satisfied in the spatial source plane, the conditions are the same as those for Gaussian-Schell model beams. The results also indicate that the variance of cosine parameters has no influence on the conditions. Our results may provide potential applications for some investigations such as the modulations of cosh-Gaussian beams and the designs of source beam parameters.

  2. A Novel Approach to Beam Steering Using Arrays Composed of Multiple Unique Radiating Modes

    Science.gov (United States)

    Labadie, Nathan Richard

    Phased array antennas have found wide application in both radar and wireless communications systems particularly as implementation costs continue to decrease. The primary advantages of electronically scanned arrays are speed of beam scan and versatility of beamforming compared to mechanically scanned fixed beam antennas. These benefits come at the cost of a few well known design issues including element pattern rolloff and mutual coupling between elements. Our primary contribution to the field of research is the demonstration of significant improvement in phased array scan performance using multiple unique radiating modes. In short, orthogonal radiating modes have minimal coupling by definition and can also be generated with reduced rolloff at wide scan angles. In this dissertation, we present a combination of analysis, full-wave electromagnetic simulation and measured data to support our claims. The novel folded ring resonator (FRR) antenna is introduced as a wideband and multi-band element embedded in a grounded dielectric substrate. Multiple radiating modes of a small ground plane excited by a four element FRR array were also investigated. A novel hemispherical null steering antenna composed of two collocated radiating elements, each supporting a unique radiating mode, is presented in the context of an anti-jam GPS receiver application. Both the antenna aperture and active feed network were fabricated and measured showing excellent agreement with analytical and simulated data. The concept of using an antenna supporting multiple radiating modes for beam steering is also explored. A 16 element hybrid linear phased array was fabricated and measured demonstrating significantly improved scan range and scanned gain compared to a conventional phased array. This idea is expanded to 2 dimensional scanning arrays by analysis and simulation of a hybrid phased array composed of novel multiple mode monopole on patch antenna sub-arrays. Finally, we fabricated and

  3. Attenuation of an ultrasonic beam by suspended particles and range of acoustic flow meters in sewer networks

    OpenAIRE

    Larrarte, Frédérique; Francois, Pierre

    2012-01-01

    Ultrasonic flow meters are commonly used in wastewater management. Under certain circumstances, a reduction in the flow meter range may occur and cause significant error in the flow rate measurement. Attenuation due to suspended particles is one of the phenomena capable of reducing the flow meter range. The present paper examines attenuation resulting from re-suspended pond sediment over a wide range of concentration values. It appears that a formula established for sand suspensions provides ...

  4. Radiation dose estimation and mass attenuation coefficients of cement samples used in Turkey

    International Nuclear Information System (INIS)

    Different cement samples commonly used in building construction in Turkey have been analyzed for natural radioactivity using gamma-ray spectrometry. The mean activity concentrations observed in the cement samples were 52, 40 and 324 Bq kg-1 for 226Ra, 232Th and 40K, respectively. The measured activity concentrations for these radionuclides were compared with the reported data of other countries and world average limits. The radiological hazard parameters such as radium equivalent activities (Raeq), gamma index (Iγ) and alpha index (Iα) indices as well as terrestrial absorbed dose and annual effective dose rate were calculated and compared with the international data. The Raeq values of cement are lower than the limit of 370 Bq kg-1, equivalent to a gamma dose of 1.5 mSv y-1. Moreover, the mass attenuation coefficients were determined experimentally and calculated theoretically using XCOM in some cement samples. Also, chemical compositions analyses of the cement samples were investigated.

  5. Control of Coherent Synchrotron Radiation and Micro-Bunching Effects During Transport of High Brightness Electron Beams

    CERN Document Server

    Douglas, D R; Hutton, A; Krafft, G A; Li, R; Neil, G R; Roblin, Y; Tennant, C D; Tsai, C -Y

    2014-01-01

    Beam quality preservation during transport of high-brightness electron beams is of general concern in the design of modern accelerators. Methods to manage incoherent synchrotron radiation (ISR) have been in place for decades; as beam brightness has improved coherent synchrotron radiation (CSR) and the microbunching instability (uBI) have emerged as performance limitations. We apply the compensation analysis of diMitri, Cornacchia, and Spampinati - as previously used by Borland - to the design of transport systems for use with low-emittance beams, and find that appropriately configured second order achromats will suppress transverse emittance growth due to CSR and appear to limit uBI gain.

  6. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    Energy Technology Data Exchange (ETDEWEB)

    Sole, C.V. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Instituto de Radiomedicina, Service of Radiation Oncology, Santiago (Chile); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Calvo, F.A. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lozano, M.A.; Gonzalez-Sansegundo, C. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Gonzalez-Bayon, L. [Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Alvarez, A. [Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lizarraga, S. [Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Garcia-Sabrido, J.L. [Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain)

    2014-02-15

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  7. Radiation Therapy of Large Intact Breasts Using a Beam Spoiler or Photons with Mixed Energies

    International Nuclear Information System (INIS)

    Radiation treatment of large intact breasts with separations of more than 24 cm is typically performed using x-rays with energies of 10 MV and higher, to eliminate high-dose regions in tissue. The disadvantage of the higher energy beams is the reduced dose to superficial tissue in the buildup region. We evaluated 2 methods of avoiding this underdosage: (1) a beam spoiler: 1.7-cm-thick Lucite plate positioned in the blocking tray 35 cm from the isocenter, with 15-MV x-rays; and (2) combining 6- and 15-MV x-rays through the same portal. For the beam with the spoiler, we measured the dose distribution for normal and oblique incidence using a film and ion chamber in polystyrene, as well as a scanning diode in a water tank. In the mixed-energy approach, we calculated the dose distributions in the buildup region for different proportions of 6- and 15-MV beams. The dose enhancement due to the beam spoiler exhibited significant dependence upon the source-to-skin distance (SSD), field size, and the angle of incidence. In the center of a 20 x 20-cm2 field at 90-cm SSD, the beam spoiler raises the dose at 5-mm depth from 77% to 87% of the prescription, while maintaining the skin dose below 57%. Comparison of calculated dose with measurements suggested a practical way of treatment planning with the spoiler-usage of 2-mm 'beam' bolus-a special option offered by in-house treatment planning system. A second method of increasing buildup doses is to mix 6- and 15-MV beams. For example, in the case of a parallel-opposed irradiation of a 27-cm-thick phantom, dose to Dmax for each energy, with respect to midplane, is 114% for pure 6-, 107% for 15-MV beam with the spoiler, and 108% for a 3:1 mixture of 15- and 6-MV beams. Both methods are practical for radiation therapy of large intact breasts

  8. Beam-induced radiation in the compact muon solenoid tracker at the Large Hadron Collider

    Indian Academy of Sciences (India)

    A P Singh; P C Bhat; N V Mokhov; S Beri

    2010-05-01

    The intense radiation environment at the Large Hadron Collider, CERN at a design energy of $\\sqrt{s} = 14$ TeV and a luminosity of 1034 cm−2S−1 poses unprecedented challenges for safe operation and performance quality of the silicon tracker detectors in the CMS and ATLAS experiments. The silicon trackers are crucial for the physics at the LHC experiments, and the inner layers, being situated only a few centimeters from the interaction point, are most vulnerable to beam-induced radiation. We have recently carried out extensive Monte Carlo simulation studies using MARS program to estimate particle fluxes and radiation dose in the CMS silicon pixel and strip trackers from proton–proton collisions at $\\sqrt{s} = 14$ TeV and from machine-induced background such as beam–gas interactions and beam halo. We will present results on radiation dose, particle fluxes and spectra from these studies and discuss implications for radiation damage and performance of the CMS silicon tracker detectors.

  9. Palliative treatment of advanced cancer using multiple nonconfluent pencil beam radiation. A pilot study

    International Nuclear Information System (INIS)

    In the era of orthovoltage radiation, multiple nonconfluent pencil beam radiation (GRID) therapy was utilized to minimize superficial normal tissue damage while delivering tumorcidal doses at specified depths in tissues. The success of GRID therapy was based on the fact that small volumes of tissues could tolerate high doses of radiation. Since the development of megavoltage radiation and skin sparing, GRID therapy has been abandoned. In a pilot study, the authors adapted the principles of GRID therapy to megavoltage photon beams to treat patients with massive tumors or recurrent tumors after tolerance doses of radiation. Twenty-two patients have been entered in the study. All patients were symptomatic and had exhaustive conventional surgery, chemotherapy, and radiotherapy approaches to treatment. A 50:50 GRID (open to closed areas) was utilized, and a prescribed dose of 1000 to 1500 cGy to the open areas was given using a single photon field. In four patients, a second GRID treated was delivered at a split course interval of 4 weeks. The follow-up in these patients ranges from 1 month to 18 months. The results of treatment have been remarkable with 20 of 22 patients achieving dramatic relief of severe symptoms, and several patients showing significant objective regression. No acute effects have been observed, including those patients having large volumes of the abdomen irradiated. No unusual skin or subcutaneous early or late damage has been observed in follow-up

  10. Evaluation of risk from space radiation with high-energy heavy ion beams

    Science.gov (United States)

    Schimmerling, W.; Wilson, J. W.; Cucinotta, F.; Kim, M. H.

    1998-01-01

    The most challenging radiation in space consists of fully ionized atomic elements with high energy for which only the few lowest energy ions can be stopped in shielding materials. The health risk from exposure to these ions and their secondary radiations generated in shield materials is poorly understood since there are few human data and a systematic study in relevant animal model systems has not been made. The accuracy of risk prediction is described as the major limiting factor in the management of space radiation risk. The expected impact of systematic studies is examined using the limited available biological data and models. Given the limitations of current predictions, models must be developed that are able to incorporate the required fundamental scientific data into accurate risk estimates. The important radiation components that can be provided for laboratory testing are identified. The use of ground-based accelerator beams to simulate space radiation is explained and quantitative scientific constraints on such facilities are derived. Three facilities, one each in the United States, in Germany and in Japan, currently have the partial capability to satisfy these constraints. A facility has been proposed using the Brookhaven National Laboratory Booster Synchrotron in the United States; in conjuction with other on-site accelerators, it will be able to provide the full range of heavy ion beams and energies required.

  11. Protective effect of allium sativum ethanol extract on cultured human lymphocytes against electron beam radiation

    International Nuclear Information System (INIS)

    The development of radioprotective agent has been the subject of intense research because exposure to ionizing radiation causes DNA damage which may cause mutation and ultimately leads to cancer, on the other hand radiotherapy has become an integral part in treatment of cancer which uses ionizing radiations like X rays, gamma rays to kill the cancer cells. Amifostine is a well-known radioprotector which is clinically approved. There are many other radioprotectors like cysteine, cystamine, serotine but they are not used because of its normal tissue toxicity. Allium sativum is commonly known as garlic which has already been reported for its medicinal properties. In this study we evaluated radioprotection property of Allium sativum on DNA damage caused by electron beam radiation in cultured human lymphocytes. Allium sativum ethanol extract was used for this study. Cell viability was performed by MTT assay. DNA damage was assessed by comet assay parameters. The cultured lymphocytes were incubated with different concentrations 10, 50 and 100 μg/mL of Allium sativum extracts for 2, 4, 6 and 24 hour time intervals. Treatment of lymphocytes with various concentration of Allium sativum extract resulted in significant decrease in the level of DNA damage (Percentage tail DNA 6%) and increase in cell viability 93% (p>0.05) compare to the radiation control group. Results of this study revealed that Allium sativum protects cultured lymphocytes when exposed to electron beam radiation at its sub lethal dose. (author)

  12. Ion-beam simulation of radiation damage produced by fast neutrons in heterophase structures

    Energy Technology Data Exchange (ETDEWEB)

    Tetelbaum, D.I., E-mail: tetelbaum@phys.unn.ru [Lobachevsky State University of Nizhny Novgorod, 23/3 Gagarin prospect, Nizhny Novgorod, 603950 (Russian Federation); Guseinov, D.V.; Vasiliev, V.K.; Mikhaylov, A.N.; Belov, A.I.; Korolev, D.S.; Obolensky, S.V. [Lobachevsky State University of Nizhny Novgorod, 23/3 Gagarin prospect, Nizhny Novgorod, 603950 (Russian Federation); Kachemtsev, A.N. [Sedakov Scientific-Research Institute, GSP-486, Nizhny Novgorod 603950 (Russian Federation)

    2014-05-01

    3D Monte-Carlo algorithm and computer code have been developed that allows choosing and optimizing the conditions of ion irradiation needed for the adequate ion-beam simulation of radiation damage under fast neutron irradiation. It is established that, by the proper selection of energy and dose of Si{sup +} ions, it is possible to reproduce well the effect of irradiation with fission neutrons of subsurface and buried layers of silicon or Si-based 2D and 3D-heterostructures. The results can be used for testing the radiation hardness of silicon-based electronic and optoelectronic device structures.

  13. In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy.

    Science.gov (United States)

    Nemoz, Christian; Kibleur, Astrid; Hyacinthe, Jean Noël; Berruyer, Gilles; Brochard, Thierry; Bräuer-Krisch, Elke; Le Duc, Géraldine; Brun, Emmanuel; Elleaume, Hélène; Serduc, Raphaël

    2016-01-01

    A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment. PMID:26698083

  14. Small Radiation Beam Dosimetry for Radiosurgery of Trigeminal Neuralgia: One Case Analysis

    Science.gov (United States)

    García-Garduño, O. A.; Lárraga-Gutiérrez, J. M.; Rodríguez-Villafuerte, M.; Martínez-Dávalos, A.; Moreno-Jiménez, S.; Suárez-Campos, J. J.; Celis, M. A.

    2008-08-01

    The use of small radiation beams for trigeminal neuralgia (TN) treatment requires high precision and accuracy in dose distribution calculations and delivery. Special attention must be kept on the type of detector to be used. In this work, the use of GafChromic EBT® radiochromic and X-OMAT V2 radiographic films for small radiation beam characterization is reported. The dosimetric information provided by the films (total output factors, tissue maximum ratios and off axis ratios) is compared against measurements with a shielded solid state (diode) reference detector. The film dosimetry was used for dose distribution calculations for the treatment of trigeminal neuralgia radiosurgery. Comparison of the isodose curves shows that the dosimetry produced with the X-OMAT radiographic film overestimates the dose distributions in the penumbra region.

  15. Small Radiation Beam Dosimetry for Radiosurgery of Trigeminal Neuralgia: One Case Analysis

    International Nuclear Information System (INIS)

    The use of small radiation beams for trigeminal neuralgia (TN) treatment requires high precision and accuracy in dose distribution calculations and delivery. Special attention must be kept on the type of detector to be used. In this work, the use of GafChromic EBT registered radiochromic and X-OMAT V2 radiographic films for small radiation beam characterization is reported. The dosimetric information provided by the films (total output factors, tissue maximum ratios and off axis ratios) is compared against measurements with a shielded solid state (diode) reference detector. The film dosimetry was used for dose distribution calculations for the treatment of trigeminal neuralgia radiosurgery. Comparison of the isodose curves shows that the dosimetry produced with the X-OMAT radiographic film overestimates the dose distributions in the penumbra region

  16. Diffraction Radiation Diagnostics for Moderate to High Energy Charged Particle Beams

    CERN Document Server

    Fiorito, R B

    2001-01-01

    Diffraction radiation (DR) is produced when a charged particle passes throughan aperture or near a discontinuity in the media in which it is traveling. DRis closely related to transition radiation (TR), which is produced when acharged particle traverses the boundary between media with different dielectricconstants. In contrast to TR, which is now extensively used for beam diagnosticpurposes, the potential of DR as a non-interceptive, multi-parameter beamdiagnostic remains largely undeveloped. For diagnostic measurements it isuseful to observe backward reflected DR from an circular aperture or slitinclined with respect to the beam velocity. However, up to now, well foundedequations for the spectral-angular intensities of backward DR from suchapertures have not been available. We present a new derivation of the spectralangular intensity of backward DR produced from an inclined slit for twoorientations of the slit axis, i.e. perpendicular and parallel to the plane ofincidence. Our mathematical approach is genera...

  17. In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy.

    Science.gov (United States)

    Nemoz, Christian; Kibleur, Astrid; Hyacinthe, Jean Noël; Berruyer, Gilles; Brochard, Thierry; Bräuer-Krisch, Elke; Le Duc, Géraldine; Brun, Emmanuel; Elleaume, Hélène; Serduc, Raphaël

    2016-01-01

    A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment.

  18. Modelling radiation fields of ion beams in tissue-like materials

    Energy Technology Data Exchange (ETDEWEB)

    Burigo, Lucas Norberto

    2014-07-16

    Fast nuclei are ionizing radiation which can cause deleterious effects to irradiated cells. The modelling of the interactions of such ions with matter and the related effects are very important to physics, radiobiology, medicine and space science and technology. A powerful method to study the interactions of ionizing radiation with biological systems was developed in the field of microdosimetry. Microdosimetry spectra characterize the energy deposition to objects of cellular size, i.e., a few micrometers. In the present thesis the interaction of ions with tissue-like media was investigated using the Monte Carlo model for Heavy-Ion Therapy (MCHIT) developed at the Frankfurt Institute for Advanced Studies. MCHIT is a Geant4-based application intended to benchmark the physical models of Geant4 and investigate the physical properties of therapeutic ion beams. We have implemented new features in MCHIT in order to calculate microdosimetric quantities characterizing the radiation fields of accelerated nucleons and nuclei. The results of our Monte Carlo simulations were compared with recent experimental microdosimetry data. In addition to microdosimetry calculations with MCHIT, we also investigated the biological properties of ion beams, e.g. their relative biological effectiveness (RBE), by means of the modified Microdosimetric-Kinetic model (MKM). The MKM uses microdosimetry spectra in describing cell response to radiation. MCHIT+MKM allowed us to study the physical and biological properties of ion beams. The main results of the thesis are as follows: MCHIT is able to describe the spatial distribution of the physical dose in tissue-like media and microdosimetry spectra for ions with energies relevant to space research and ion-beam cancer therapy; MCHIT+MKM predicts a reduction of the biological effectiveness of ions propagating in extended medium due to nuclear fragmentation reactions; We predicted favourable biological dose-depth profiles for monoenergetic helium and

  19. Approximate analytical formulas for total cross sections and for mass attenuation coefficients of narrow gamma beams for 3 to 100 MeV

    International Nuclear Information System (INIS)

    Tabulated data by Storm and Israel for total cross sections and mass attenuation coefficients for narrow gamma beams of 3 to 100 MeV and elements with Z equal to 26 to 94 were approximated by an analytical formula analogous to the ultrarelativistic case of Compton scattering and pair creation. The reproduction accuracy of the tabulated data is better than 1 to 2% in a region of 3 to 60 MeV and better than 3 to 4% from 60 to 100 MeV. In the analytical formula three constants were needed for each Z, the tables of which are given. (author)

  20. Instrumentation for beam radiation and luminosity measurement in the CMS experiment using novel detector technologies

    CERN Document Server

    Guthoff, Moritz

    2016-01-01

    The higher energy and luminosity of the LHC initiated the development of dedicated technologies for radiation monitoring and luminosity measurement. A pixelated luminosity detector counts coincidences in several three layer telescopes of silicon pixel detectors to measure the luminosity for each colliding LHC bunch pair. In addition, charged particle tracking allows to monitor the location of the collision point.The upgraded fast beam conditions monitor measures the particle flux using 24 two pad single crystalline diamond sensors, equipped with a fast front-end ASIC produced in 130 nm CMOS technology. The excellent time resolution is used to separate collision products from machine induced background.A new beam-halo monitor at larger radius exploits Cerenkov light produced by relativistic charged particles in fused quartz crystals to provide direction sensitivity and time resolution to separate incoming and outgoing particles. The back-end electronics of the beam monitoring systems includes dedicated modules...

  1. Fabrication and optimization of a fiber-optic radiation sensor for proton beam dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Jang, K.W.; Yoo, W.J.; Seo, J.K.; Heo, J.Y.; Moon, J.; Park, J.-Y. [School of Biomedical Engineering, College of Biomedical and Health Science, Research Institute of Biomedical Engineering, Konkuk University, Chungju 380-701 (Korea, Republic of); Hwang, E.J.; Shin, D.; Park, S.-Y. [Proton Therapy Center, National Cancer Center, Goyang 410-769 (Korea, Republic of); Cho, H.-S. [Basic Atomic Energy Research Institute and Department of Radiological Science, Yonsei University, Wonju 220-710 (Korea, Republic of); Lee, B., E-mail: bslee@kku.ac.kr [School of Biomedical Engineering, College of Biomedical and Health Science, Research Institute of Biomedical Engineering, Konkuk University, Chungju 380-701 (Korea, Republic of)

    2011-10-01

    In this study, we fabricated a fiber-optic radiation sensor for proton therapy dosimetry and measured the output and the peak-to-plateau ratio of scintillation light with various kinds of organic scintillators in order to select an organic scintillator appropriate for measuring the dose of a proton beam. For the optimization of an organic scintillator, the linearity between the light output and the stopping power of a proton beam was evaluated for two different diameters of the scintillator, and the angular dependency and standard deviation of the light pulses were investigated for four different scintillator lengths. We also evaluated the linearity between the light output and the dose rate and monitor units of a proton generator, respectively. The relative depth-dose curve of the proton beam was obtained and corrected using Birk's theory.

  2. Growth Defects in Langasite Crystals Observed with White Beam Synchrotron Radiation Topography

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Langasite single crystal was grown by the Czochralski method and its perfection was assessed by white beam synchrotron radiation topography. It is found that the growth core and the growth striations are the primary growth defects and they show strong X-ray kinematical contrast in the topographs. Another typical defect in LGS crystal is dislocation. The formation mechanisms of these growth defects in LGS crystals were discussed.

  3. Exercise for laboratory comparison of calibration coefficient in 137Cs beam, radiation protection - 2013/2014

    International Nuclear Information System (INIS)

    This work deals with the preliminary results of the second exercise of comparing the radiation monitors calibration laboratories in Brazil. The exercise involved eight laboratories and the measured quantity is the air kerma in a beam of 137Cs for radioprotection. The exercise was conducted by the LNMRI/IRD, in a star shaped arrangement from October 2013 to July 2015. The largest deviation was 2% of the calibration coefficient that is acceptable for applications in radioprotection. (author)

  4. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Antonio C. Westphalen

    2009-04-01

    Full Text Available PURPOSE: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. MATERIAL AND METHODS: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher’s exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25 and those imaged more than 3 years after therapy (n = 34. Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. RESULTS: Thirty-four of 59 patients (58% had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59 for reader 1 and 71% for reader 2 (42/59. For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2. CONCLUSION: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy.

  5. Beam plug replacement and alignment under high radiation conditions for cold neutron facilities at Hanaro

    International Nuclear Information System (INIS)

    Full text : The HANARO, an open-tank-in-pool type research reactor of a 30 MWth power in Korea, has been operating for 15 years since its initial criticality in February 1995. The beam port assigned for the cold neutron at HANARO had been used for an 8-m SANS without neutron guides until it was replaced by a cold neutron guide system in 2008. It was developed a cold neutron guide system for the delivery of cold neutrons from the cold neutron source in the reactor to the neutron scattering instruments in the guide hall. Since the HANARO has been operated from 1995, it was a big challenge to replace the existing plug and shutter with the new facilities under high radiation conditions. When the old plug was removed from the beam port in 2008, the radiation level was 230 mSv/hr at the end of beam port. In addition to that, there were more difficult situations such as the poor as-built dimensions of the beam port, limited work space and time constraint due to other constructions in parallel in the reactor hall. Before the removal of the old plug the level of the radiation was measured coming out through a small hole of the plug to estimate the radiation level during the removal of the old plug and installation of a new plug. Based on the measurement and analysis results, special tools and various shielding facilities were developed for the removal of old in-pile plug and the installation of the new in-pile plug assembly safely. In 2008, the old plug and shutter were successfully replaced by the new plug and shutter as shown in this article with a minimum exposure to the workers. A laser tracker system was also one of the main factors in our successful installation and alignment under high radiation conditions and limited work space. The laser tracker was used to measure and align all the mechanical facilities and the neutron guides with a minimum radiation exposure to workers. The alignment of all the guides and accessories were possible during reactor operation because

  6. Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System

    Directory of Open Access Journals (Sweden)

    Kazuhisa Nakajima

    2014-12-01

    Full Text Available We present a new external-beam radiation therapy system using very-high-energy (VHE electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.

  7. Radiation hygienization of cattle and swine slurry with high energy electron beam

    Science.gov (United States)

    Skowron, Krzysztof; Olszewska, Halina; Paluszak, Zbigniew; Zimek, Zbigniew; Kałuska, Iwona; Skowron, Karolina Jadwiga

    2013-06-01

    The research was carried out to assess the efficiency of radiation hygienization of cattle and swine slurry of different density using the high energy electron beam based on the inactivation rate of Salmonella ssp, Escherichia coli, Enterococcus spp and Ascaris suum eggs. The experiment was conducted with use of the linear electron accelerator Elektronika 10/10 in Institute of Nuclear Chemistry and Technology in Warsaw. The inoculated slurry samples underwent hygienization with high energy electron beam of 1, 3, 5, 7 and 10 kGy. Numbers of reisolated bacteria were determined according to the MPN method, using typical microbiological media. Theoretical lethal doses, D90 doses and hygienization efficiency of high energy electron beam were determined. The theoretical lethal doses for all tested bacteria ranged from 3.63 to 8.84 kGy and for A. suum eggs from 4.07 to 5.83 kGy. Salmonella rods turned out to be the most sensitive and Enterococcus spp were the most resistant to electron beam hygienization. The effectiveness or radiation hygienization was lower in cattle than in swine slurry and in thick than in thin one. Also the species or even the serotype of bacteria determined the dose needed to inactivation of microorganisms.

  8. Radiation defect dynamics in Si at room temperature studied by pulsed ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, J. B.; Myers, M. T. [Lawrence Livermore National Laboratory, Livermore, California 94550, USA and Department of Nuclear Engineering, Texas A& M University, College Station, Texas 77843 (United States); Charnvanichborikarn, S.; Bayu Aji, L. B.; Kucheyev, S. O. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Shao, L. [Department of Nuclear Engineering, Texas A& M University, College Station, Texas 77843 (United States)

    2015-10-07

    The evolution of radiation defects after the thermalization of collision cascades often plays the dominant role in the formation of stable radiation disorder in crystalline solids of interest to electronics and nuclear materials applications. Here, we explore a pulsed-ion-beam method to study defect interaction dynamics in Si crystals bombarded at room temperature with 500 keV Ne, Ar, Kr, and Xe ions. The effective time constant of defect interaction is measured directly by studying the dependence of lattice disorder, monitored by ion channeling, on the passive part of the beam duty cycle. The effective defect diffusion length is revealed by the dependence of damage on the active part of the beam duty cycle. Results show that the defect relaxation behavior obeys a second order kinetic process for all the cases studied, with a time constant in the range of ∼4–13 ms and a diffusion length of ∼15–50 nm. Both radiation dynamics parameters (the time constant and diffusion length) are essentially independent of the maximum instantaneous dose rate, total ion dose, and dopant concentration within the ranges studied. However, both the time constant and diffusion length increase with increasing ion mass. This demonstrates that the density of collision cascades influences not only defect production and annealing efficiencies but also the defect interaction dynamics.

  9. The approximation of energetic dependences of mass attenuation coefficients of γ-radiation for CsI and Zn Se scintillators

    International Nuclear Information System (INIS)

    The formulae for energetic dependences of the mass attenuation coefficients of γ-radiation of CsI and Zn Se scintillators in the range of energies of 0.01-100 MeV are found. The difference of approximative dependences from the source data is less than 3%

  10. Association of amphibians with attenuation of ultraviolet-b radiation in montane ponds

    Science.gov (United States)

    Adams, M.J.; Schindler, D.E.; Bury, B.R.

    2001-01-01

    Ambient ultraviolet-b (UV-B) radiation (280-320 nm) has increased at north-temperate latitudes in the last two decades. UV-B can be detrimental to amphibians, and amphibians have shown declines in some areas during this same period. We documented the distribution of amphibians and salmonids in 42 remote, subalpine and alpine ponds in Olympic National Park, Washington, United States. We inferred relative exposure of amphibian habitats to UV-B by estimating the transmission of 305- and 320-nm radiation in pond water. We found breeding Ambystoma gracile, A. macrodactylum and Rana cascadae at 33%, 31%, and 45% of the study sites, respectively. Most R. cascadae bred in fishless shallow ponds with relatively low transmission of UV-B. The relationship with UV-B exposure remained marginally significant even after the presence of fish was included in the model. At 50 cm water depth, there was a 55% reduction in incident 305-nm radiation at sites where breeding populations of R. cascadae were detected compared to other sites. We did not detect associations between UV-B transmission and A. gracile or A. macrodactylum. Our field surveys do not provide evidence for decline of R. cascadae in Olympic National Park as has been documented in Northern California, but are consistent with the hypothesis that the spatial distribution of R. cascadae breeding sites is influenced by exposure to UV-B. Substrate or pond depth could also be related to the distribution of R. cascadae in Olympic National Park.

  11. Treatment of Head and Neck Paragangliomas With External Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dupin, Charles, E-mail: c.dupin@bordeaux.unicancer.fr [Department of Radiotherapy, Comprehensive Cancer Center, Institut Bergonié, Bordeaux (France); Lang, Philippe [Department of Radiotherapy, Pitié Salpétrière, Paris (France); Dessard-Diana, Bernadette [Department of Radiotherapy, Hopital Européen Georges Pompidou, Paris (France); Simon, Jean-Marc; Cuenca, Xavier; Mazeron, Jean-Jacques; Feuvret, Loïc [Department of Radiotherapy, Pitié Salpétrière, Paris (France)

    2014-06-01

    Purpose: To retrospectively assess the outcomes of radiation therapy in patients with head and neck paragangliomas. Methods and Materials: From 1990 to 2009, 66 patients with 81 head and neck paragangliomas were treated by conventional external beam radiation therapy in 25 fractions at a median dose of 45 Gy (range, 41.4-68 Gy). One case was malignant. The median gross target volume and planning target volume were 30 cm{sup 3} (range, 0.9-243 cm{sup 3}) and 116 cm{sup 3} (range, 24-731 cm{sup 3}), respectively. Median age was 57.4 years (range, 15-84 years). Eleven patients had multicentric lesions, and 8 had family histories of paraganglioma. Paragangliomas were located in the temporal bone, the carotid body, and the glomus vagal in 51, 18, and 10 patients, respectively. Forty-six patients had exclusive radiation therapy, and 20 had salvage radiation therapy. The median follow-up was 4.1 years (range, 0.1-21.2 years). Results: One patient had a recurrence of temporal bone paraganglioma 8 years after treatment. The actuarial local control rates were 100% at 5 years and 98.7% at 10 years. Patients with multifocal tumors and family histories were significantly younger (42 years vs 58 years [P=.002] and 37 years vs 58 years [P=.0003], respectively). The association between family predisposition and multifocality was significant (P<.001). Two patients had cause-specific death within the 6 months after irradiation. During radiation therapy, 9 patients required hospitalization for weight loss, nausea, mucositis, or ophthalmic zoster. Two late vascular complications occurred (middle cerebral artery and carotid stenosis), and 2 late radiation-related meningiomas appeared 15 and 18 years after treatment. Conclusion: Conventional external beam radiation therapy is an effective and safe treatment option that achieves excellent local control; it should be considered as a first-line treatment of choice for head and neck paragangliomas.

  12. Obtaining the mass attenuation coefficient of the wood to a beam of gamma-ray of 241Am

    International Nuclear Information System (INIS)

    Full text: The quality of wood produced in Brazil reforestation has been the subject of many discussions in the Forestry Sector. SeEKXing to produce a rapid growth and wood quality, the Forestry Sector, found in Applied Nuclear Physics, a precise method of determining the density of wood known as ad hoc technique of attenuation of gamma-ray. The radioisotope used in this technique is that it has a picture 241Am peak of 59.6 keV gamma-ray. This work has the objective of determining the mass attenuation coefficient of wood of the genus Eucalyptus for 241Am radioisotope. We used 324 samples of wood from six different treatments: a seminal of Eucalyptus grandis; two clones of E. grandis; three clones of the hybrid E. grandis x E. urophylla. The same assay was used for the six treatments. It was determined the basic density of the samples by the method of immersion in water and then the basic density was converted into apparent density in the moisture equilibrium and it was determined the attenuation coefficient of mass. Preliminary results showed that the attenuation coefficient of mass did not vary between treatments, and its average value 0.1822 ± 0.0015. It was to here that the attenuation coefficient of mass in the wood of the genus Eucalyptus in moisture equilibrium can be constant. (author)

  13. Radiation dose estimation and mass attenuation coefficients of marble used in Turkey

    International Nuclear Information System (INIS)

    In this study the natural radioactivity in marble samples used in Turkey was measured by means of gamma spectrometry. The results showed that the specific activities of 226Ra, 232Th and 40K ranged from 10 to 92 Bq kg-1, from 4 to 122 Bq kg-1 and from 28 to 676 Bq kg-1, respectively. The radiological hazards in marble samples due to the natural radioactivity were inferred from calculations of radium equivalent activities (Raeq), indoor absorbed dose rate in air values, the annual effective dose and gamma and alpha indexes. These radiological parameters were evaluated and compared with the internationally recommended values. The measurements showed that marble samples used in Turkey have low level of natural radioactivity; therefore, the use of these types of marble in dwellings is safe for inhabitants. Mass attenuation coefficients (μ/ρ) were obtained both experimentally and theoretically for different marble samples produced in Turkey by using gamma-ray transmission method. Experimental values showed a good agreement with the theoretical values.

  14. Radiation dose estimation and mass attenuation coefficients of cement samples used in Turkey.

    Science.gov (United States)

    Damla, N; Cevik, U; Kobya, A I; Celik, A; Celik, N; Van Grieken, R

    2010-04-15

    Different cement samples commonly used in building construction in Turkey have been analyzed for natural radioactivity using gamma-ray spectrometry. The mean activity concentrations observed in the cement samples were 52, 40 and 324 Bq kg(-1) for (226)Ra, (232)Th and (40)K, respectively. The measured activity concentrations for these radionuclides were compared with the reported data of other countries and world average limits. The radiological hazard parameters such as radium equivalent activities (Ra(eq)), gamma index (I(gamma)) and alpha index (I(alpha)) indices as well as terrestrial absorbed dose and annual effective dose rate were calculated and compared with the international data. The Ra(eq) values of cement are lower than the limit of 370 Bq kg(-1), equivalent to a gamma dose of 1.5 mSv y(-1). Moreover, the mass attenuation coefficients were determined experimentally and calculated theoretically using XCOM in some cement samples. Also, chemical compositions analyses of the cement samples were investigated. PMID:20018450

  15. Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Mohammad Eftekhari

    2015-01-01

    Full Text Available Objective(s: Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. Methods: To minimize potential confounding factors, only those patients with low 10-year risk of coronary artery disease (based on Framingham risk scoring were included. All patients were initially treated by modified radical mastectomy and then were managed by postoperative 3D Conformal Radiation Therapy (CRT to the surgical bed with an additional 1-cm margin, delivered by 46-50 Gy (in 2 Gy daily fractions over a 5-week course. The same dose-adjusted chemotherapy regimen (including anthracyclines, cyclophosphamide and taxol was given to all patients. Six months after radiation therapy, all patients underwent cardiac SPECT for the evaluation of myocardial perfusion. Results: A total of 71 patients with a mean age of 45.3±7.2 years [35 patients with leftsided breast cancer (exposed and 36 patients with right-sided cancer (controls] were enrolled. Dose-volume histogram (DVH [showing the percentage of the heart exposed to >50% of radiation] was significantly higher in patients with left-sided breast cancer. Visual interpretation detected perfusion abnormalities in 42.9% of cases and 16.7% of controls (P=0.02, Odds ratio=1.46. In semiquantitative segmental analysis, only apical (28.6% versus 8.3%, P=0.03 and anterolateral (17.1% versus 2.8%, P=0.049 walls showed significantly reduced myocardial perfusion in the exposed group. Summed Stress Score (SSS of>3 was observed in twelve cases (34.3%, while in five of the controls (13.9%,(Odds ratio=1.3. There was no significant difference between the groups regarding left ventricular ejection fraction. Conclusion: The risk of radiation induced myocardial

  16. Electron-Beam Noise and spontaneous emission Suppression and the Fundamental Coherence Limits of Free Electron Radiators

    Science.gov (United States)

    Gover, Avraham

    2010-02-01

    It is shown that the electron beam current noise can be reduced at optical frequencies below the classical shot-noise limit. This self-ordering phenomenon takes place due to longitudinal collective Coulomb interaction when the beam parameters are set to excite Langmuir plasma-wave single mode oscillation [1]. Full 3-D particle dynamics simulations confirm the theoretical model. Based on this result, it is shown that it is possible to obtain sub-radiance (in the sense of Dicke [2]) of spontaneous emission from electron-beam radiators. This results in fundamental limit expressions for the coherence of FELs and other e-beam radiators, analogously to the Schawlow-Towns limit [3]. Surpassing the shot-noise limit, the coherence of free electron laser radiation is limited by the e-beam energy spread at frequencies below the IR, and fundamentally limited by quantum noise at higher frequencies. )

  17. Intense microwave radiation from a repetitive backward-wave oscillator driven by a relativistic electron beam

    International Nuclear Information System (INIS)

    High-power microwaves (20--50 MW, 8.8 GHz) have been produced in repetitive pulses at a rate of 10 Hz in a joint experiment by Harry Diamond Laboratories and Sandia National Laboratories. These microwaves were produced with Harry Diamond Laboratories' backward-wave oscillator (BWO), driven by a 600 to 800-kV, 2-kA electron beam, which was guided by a magnetic field of variable strength from 0.75 to 1.05 T. The beam was produced with Sandia National Laboratories' repetitive high-voltage pulser, RAVEN. Microwave diagnostic instrumentation included a directional coupler, heterodyne receiver, dispersive waveguide delay line, and calorimeter. In a train of 10 pulses, the shape, duration, and amplitude of the injection voltage and beam current remained unchanged for each individual pulse. The intensity of the final microwave pulse was 40% of the first pulse, and the final pulse was 80% as long as the first. The basic pulse shape remained unchanged. More intense microwave radiation should be obtained with a higher magnetic field. Computer simulations using the code magic predicted the characteristic dip in the magnetic field strength versus microwave power output curve. Code predictions of microwave power output with a warm beam agree very well with experimental results. Finally, cyclotron resonance is presented in a descriptive fashion to account for the power output dip. This is the first experiment with a repetitively pulsed high-power BWO driven by a relativistic electron beam performed outside the USSR

  18. Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation

    Science.gov (United States)

    Chen, Jiangang; Hou, Gary Y.; Marquet, Fabrice; Han, Yang; Camarena, Francisco; Konofagou, Elisa

    2015-10-01

    Acoustic attenuation represents the energy loss of the propagating wave through biological tissues and plays a significant role in both therapeutic and diagnostic ultrasound applications. Estimation of acoustic attenuation remains challenging but critical for tissue characterization. In this study, an attenuation estimation approach was developed using the radiation-force-based method of harmonic motion imaging (HMI). 2D tissue displacement maps were acquired by moving the transducer in a raster-scan format. A linear regression model was applied on the logarithm of the HMI displacements at different depths in order to estimate the acoustic attenuation. Commercially available phantoms with known attenuations (n=5 ) and in vitro canine livers (n=3 ) were tested, as well as HIFU lesions in in vitro canine livers (n=5 ). Results demonstrated that attenuations obtained from the phantoms showed a good correlation ({{R}2}=0.976 ) with the independently obtained values reported by the manufacturer with an estimation error (compared to the values independently measured) varying within the range of 15-35%. The estimated attenuation in the in vitro canine livers was equal to 0.32   ±   0.03 dB cm-1 MHz-1, which is in good agreement with the existing literature. The attenuation in HIFU lesions was found to be higher (0.58   ±   0.06 dB cm-1 MHz-1) than that in normal tissues, also in agreement with the results from previous publications. Future potential applications of the proposed method include estimation of attenuation in pathological tissues before and after thermal ablation.

  19. Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation.

    Science.gov (United States)

    Chen, Jiangang; Hou, Gary Y; Marquet, Fabrice; Han, Yang; Camarena, Francisco; Konofagou, Elisa

    2015-10-01

    Acoustic attenuation represents the energy loss of the propagating wave through biological tissues and plays a significant role in both therapeutic and diagnostic ultrasound applications. Estimation of acoustic attenuation remains challenging but critical for tissue characterization. In this study, an attenuation estimation approach was developed using the radiation-force-based method of harmonic motion imaging (HMI). 2D tissue displacement maps were acquired by moving the transducer in a raster-scan format. A linear regression model was applied on the logarithm of the HMI displacements at different depths in order to estimate the acoustic attenuation. Commercially available phantoms with known attenuations (n = 5) and in vitro canine livers (n = 3) were tested, as well as HIFU lesions in in vitro canine livers (n = 5). Results demonstrated that attenuations obtained from the phantoms showed a good correlation (R² = 0.976) with the independently obtained values reported by the manufacturer with an estimation error (compared to the values independently measured) varying within the range of 15-35%. The estimated attenuation in the in vitro canine livers was equal to 0.32   ±   0.03 dB cm(-1) MHz(-1), which is in good agreement with the existing literature. The attenuation in HIFU lesions was found to be higher (0.58   ±   0.06 dB cm(-1) MHz(-1)) than that in normal tissues, also in agreement with the results from previous publications. Future potential applications of the proposed method include estimation of attenuation in pathological tissues before and after thermal ablation. PMID:26371501

  20. Recoil separators for radiative capture using radioactive ion beams. Recent advances and detection techniques

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, Chris [TRIUMF, Vancouver, BC (Canada); Greife, Uwe; Hager, Ulrike [Colorado School of Mines, Golden, CO (United States)

    2014-06-15

    Radiative capture reactions involving the fusion of hydrogen or helium are ubiquitous in the stellar history of the universe, and are some of the most important reactions in the processes that govern nucleosynthesis and energy generation in both static and explosive scenarios. However, radiative capture reactions pose some of the most difficult experimental challenges due to extremely small cross sections. With the advent of recoil separators and techniques in inverse kinematics, it is now possible to measure radiative capture reactions on very short-lived radioactive nuclei, and in the presence of high experimental backgrounds. In this paper we review the experimental needs for making measurements of astrophysical importance on radiative capture reactions. We also review some of the important historical advances in the field of recoil separators as well as describe current techniques and performance milestones, including descriptions of some of the separators most recently working at radioactive ion beam facilities, such as DRAGON at TRIUMF and the DRS at the Holifield Radioactive Ion Beam Facility. We will also summarize some of the scientific highlight measurements at the RIB facilities. (orig.)

  1. Study on the radiation problem caused by electron beam loss in accelerator tubes

    Institute of Scientific and Technical Information of China (English)

    LI Quan-Feng; GUO Bing-Qi; ZHANG Jie-Xi; CHEN Huai-Bi

    2008-01-01

    The beam dynamic code PARMELA was used to simulate the transportation process of accelerating electrons in S-band SW linacs with different energies of 2.5, 6 and 20 MeV. The results indicated that in the ideal condition, the percentage of electron beam loss was 50% in accelerator tubes. Also we calculated the spectrum, the location and angular distribution of the lost electrons. Calculation performed by Monte Carlo code MCNP demonstrated that the radiation distribution of lost electrons was nearly uniform along the tube axis, the angular distributions of the radiation dose rates of the three tubes were similar, and the highest leaking dose was at the angle of 160° with respect to the axis. The lower the energy of the accelerator, the higher the radiation relative leakage. For the 2.5 MeV accelerator, the maximum dose rate reached 5% of the main dose and the one on the head of the electron gun was 1%, both of which did not meet the eligible protection requirement for accelerators. We adopted different shielding designs for different accelerators. The simulated result showed that the shielded radiation leaking dose rates fulfilled the requirement.

  2. Beam and radiation tests of a fast, warm liquid open-quotes swimming poolclose quotes calorimeter

    International Nuclear Information System (INIS)

    A fast, warm liquid calorimeter module with lead absorber immersed in tetramethyl pentane (TMP) as the liquid medium (i.e. a open-quotes swimming poolclose quotes configuration) has been built and tested in a high energy beam at FNAL, and exposed to intense radiation from a strong Co60 source. A two-tower prototype, incorporating the concept of the electrostatic transformer for fast readout, exhibited very good uniformity and small cross-talk in the beam test. This same calorimeter was exposed to over 10 Mrad of radiation from the Co60 source, and the electron drift lifetime was measured as a function of accumulated dose. The lifetime improved significantly with small doses of radiation, up to a few hundred krad, then decreased gradually at higher doses, and extrapolated to a minimum useful lifetime of 0.1 μs at over 150 Mrad. This result was confirmed by measurements on a small single-electrode test cell which was irradiated to more than 25 Mrad. In this case, the lifetime decreased from 10μs to 0.1 μs when extrapolated to a dose of over 600 Mrad. This cell was also used to measure the effect of positive ion open-quotes space chargeclose quotes buildup under intense radiation. The results suggest that such effects are small even at the highest intensity available, about 1.3 Mrad/day, for applied fields ≥25 kV/cm

  3. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice.

    Science.gov (United States)

    Ran, Yuanyuan; Wang, Ran; Gao, Qian; Jia, Qiutian; Hasan, Murtaza; Awan, Muhammad Umer Farooq; Tang, Bo; Zhou, Rui; Dong, Yiming; Wang, Xiao; Li, Qiang; Ma, Hong; Deng, Yulin; Qing, Hong

    2014-07-01

    Dragon's blood (DB) possesses great medicinal values due to the presence of several phenolic compounds. This study was designed to investigate the effects of DB and its extracts (DBEs) on oxidative stress in mice exposed to whole body (60)Co-γ irradiation (4 Gy). DB and DBEs were intragastrically administered to mice for 5 d prior to radiation. The antioxidant activities, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels in liver and spleen were measured using kits. Furthermore, DB and DBE effects were determined by organ indices and histology of liver and spleen. Our results indicated that the DB and DBE-treated groups showed a significant decrease (P < 0.05) in levels of MDA in liver and spleen compared with the irradiation-only group. Moreover, the activity of SOD, CAT and the level of GSH in liver and spleen tissue were enhanced significantly (P < 0.05) in the DB and DBE groups. DB and DBE also had a significant effect on the recovery of thymus indices. The histological observations of groups having treatment with DB and DBE indicated significant reduction in the radiation-induced damage to the liver and spleen, together with improvement in the morphology of the liver and spleen. These results suggest that DB and DBE treatment prevents radiation-induced oxidative stress injury and restores antioxidant status and histopathological changes in the liver and spleen, but there is need for further study to explore the precise molecular mechanism and strategy for optimal practical application of DB and DBE.

  4. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice

    International Nuclear Information System (INIS)

    Dragon's blood (DB) possesses great medicinal values due to the presence of several phenolic compounds. This study was designed to investigate the effects of DB and its extracts (DBEs) on oxidative stress in mice exposed to whole body 60Co-γ irradiation (4 Gy). DB and DBEs were intragastrically administered to mice for 5 d prior to radiation. The antioxidant activities, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels in liver and spleen were measured using kits. Furthermore, DB and DBE effects were determined by organ indices and histology of liver and spleen. Our results indicated that the DB and DBE-treated groups showed a significant decrease (P < 0.05) in levels of MDA in liver and spleen compared with the irradiation-only group. Moreover, the activity of SOD, CAT and the level of GSH in liver and spleen tissue were enhanced significantly (P < 0.05) in the DB and DBE groups. DB and DBE also had a significant effect on the recovery of thymus indices. The histological observations of groups having treatment with DB and DBE indicated significant reduction in the radiation-induced damage to the liver and spleen, together with improvement in the morphology of the liver and spleen. These results suggest that DB and DBE treatment prevents radiation-induced oxidative stress injury and restores antioxidant status and histopathological changes in the liver and spleen, but there is need for further study to explore the precise molecular mechanism and strategy for optimal practical application of DB and DBE. (author)

  5. Application of THz probe radiation in low-coherent tomographs based on spatially separated counterpropagating beams

    Energy Technology Data Exchange (ETDEWEB)

    Kuritsyn, I I; Shkurinov, A P; Nazarov, M M [Department of Physics, M.V. Lomonosov Moscow State University (Russian Federation); Mandrosov, V I [Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow Region (Russian Federation); Cherkasova, O P [Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk (Russian Federation)

    2013-10-31

    A principle of designing a high-resolution low-coherent THz tomograph, which makes it possible to investigate media with a high spatial resolution (in the range λ{sub 0} – 2λ{sub 0}, where λ{sub 0} is the average probe wavelength) is considered. The operation principle of this tomograph implies probing a medium by radiation with a coherence length of 8λ{sub 0} and recording a hologram of a focused image of a fixed layer of this medium using spatially separated counterpropagating object and reference beams. Tomograms of the medium studied are calculated using a temporal approach based on application of the time correlation function of probe radiation. (terahertz radiation)

  6. Radiation reaction induced spiral attractors in ultra-intense colliding laser beams

    CERN Document Server

    Gong, Z; Shou, Y R; Qiao, B; Chen, C E; Xu, F R; He, X T; Yan, X Q

    2016-01-01

    The radiation reaction effects on electron dynamics in counter-propagating circularly polarized laser beams are investigated through the linearization theorem and the results are in great agreement with numeric solutions. For the first time, the properties of fixed points in electron phase-space were analyzed with linear stability theory, showing that center nodes will become attractors if the classical radiation reaction is considered. Electron dynamics are significantly affected by the properties of the fixed points and the electron phase-space densities are found to be increasing exponentially near the attractors. The density growth rates are derived theoretically and further verified by particle-in-cell simulations, which can be detected in experiments to explore the effects of radiation reaction qualitatively. The attractor can also facilitate to realize a series of nanometer-scaled flying electron slices via adjusting the colliding laser frequencies.

  7. Belle-II VXD radiation monitoring and beam abort with sCVD diamond sensors

    Science.gov (United States)

    Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, T.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; Divekar, S. T.; Doležal, Z.; Dutta, D.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C.; Kandra, J.; Kang, K. H.; Kato, E.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kvasnička, P.; Lanceri, L.; Lettenbicher, J.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Negishi, K.; Nisar, N. K.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Rozanska, M.; Sandilya, S.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Tanaka, S.; Tanida, K.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, Lorenzo; Volpi, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.

    2016-07-01

    The Belle-II VerteX Detector (VXD) has been designed to improve the performances with respect to Belle and to cope with an unprecedented luminosity of 8 ×1035cm-2s-1 achievable by the SuperKEKB. Special care is needed to monitor both the radiation dose accumulated throughout the life of the experiment and the instantaneous radiation rate, in order to be able to promptly react to sudden spikes for the purpose of protecting the detectors. A radiation monitoring and beam abort system based on single-crystal diamond sensors is now under an active development for the VXD. The sensors will be placed in several key positions in the vicinity of the interaction region. The severe space limitations require a challenging remote readout of the sensors.

  8. Signatures of quantum radiation reaction in laser-electron-beam collisions

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H. Y. [Helmholtz Institute Jena, Fröbelstieg 3, 07743 Jena (Germany); Yan, X. Q. [State Key Laboratory of Nuclear Physics and Technology, and Key Lab of High Energy Density Physics Simulation, CAPT, Peking University, Beijing 100871 (China); Zepf, M., E-mail: m.zepf@uni-jena.de [Helmholtz Institute Jena, Fröbelstieg 3, 07743 Jena (Germany); School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom)

    2015-09-15

    Electron dynamics in the collision of an electron beam with a high-intensity focused ultrashort laser pulse are investigated using three-dimensional QED particle-in-cell (PIC) simulations, and the results are compared with those calculated by classical Landau and Lifshitz PIC simulations. Significant differences are observed from the angular dependence of the electron energy distribution patterns for the two different approaches, because photon emission is no longer well approximated by a continuous process in the quantum radiation-dominated regime. The stochastic nature of photon emission results in strong signatures of quantum radiation-reaction effects under certain conditions. We show that the laser spot size and duration greatly influence these signatures due to the competition of QED effects and the ponderomotive force, which is well described in the classical approximation. The clearest signatures of quantum radiation reaction are found in the limit of large laser spots and few cycle pulse durations.

  9. Disinfestation of agricultural products with electron beams and their radiation tolerance

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Toru [National Food Research Inst., Tsukuba, Ibaraki (Japan)

    1996-12-31

    Some agricultural products contaminated with insect pests are fumigated with methyl bromide for quarantine purposes. However, the use of methyl bromide is preferably restricted because of its ozone depleting effect. Therefore, establishing alternative quarantine techniques is highly desirable; one such technique is exposure to ionizing radiation. Few data are available on the effects of radiation on insect pests other than fruit flies and stored-product insects and on the radiation tolerance of host commodities. Radiation technology as an alternative to methyl bromide fumigation will be used to inactivate not only insects but also mites, spider mites, thrips, nematodes, scales, mealybugs and thrips contaminating fruits, grains, cut flowers, vegetables, timbers, seedlings and seeds. In order to collect data on the effects of irradiation on pests and host commodities, IAEA and FAO have conducted an international project, `FAO/IAEA Coordinated Research Programme on Irradiation as a Quarantine Treatment of Mites, Nematodes and Insects other than Fruit Fly` since 1992. The project determines the minimum doses necessary to inactivate pests and the maximum doses host commodities tolerate. All pests except nematodes can be inactivated at doses 400Gy or lower. Various varieties of cut flowers and herbs are tolerant to 400Gy of radiation, although some flowers and herbs such as chrysanthemum, rose, lily, calla, anthurium, sweet pea, iris, dill, basil and arugula are intolerant to 200Gy of radiation. Japanese research project on treatment of cut flowers with electron beams carried out mainly by Yokohama Plant Protection Station greatly contributes to these conclusions. Aqueous solution (2%) of sucrose, glucose, fructose or maltose prevents radiation-induced detrimental effects of radiation on chrysanthemums. Sugars reduce radiation-induced physiological deterioration of chrysanthemums. (author)

  10. Quantitative analysis of artifacts in 4D DSA: the relative contributions of beam hardening and scatter to vessel dropout behind highly attenuating structures

    Science.gov (United States)

    Hermus, James; Szczykutowicz, Timothy P.; Strother, Charles M.; Mistretta, Charles

    2014-03-01

    When performing Computed Tomographic (CT) image reconstruction on digital subtraction angiography (DSA) projections, loss of vessel contrast has been observed behind highly attenuating anatomy, such as dental implants and large contrast filled aneurysms. Because this typically occurs only in a limited range of projection angles, the observed contrast time course can potentially be altered. In this work, we have developed a model for acquiring DSA projections that models both the polychromatic nature of the x-ray spectrum and the x-ray scattering interactions to investigate this problem. In our simulation framework, scatter and beam hardening contributions to vessel dropout can be analyzed separately. We constructed digital phantoms with large clearly defined regions containing iodine contrast, bone, soft issue, titanium (dental implants) or combinations of these materials. As the regions containing the materials were large and rectangular, when the phantoms were forward projected, the projections contained uniform regions of interest (ROI) and enabled accurate vessel dropout analysis. Two phantom models were used, one to model the case of a vessel behind a large contrast filled aneurysm and the other to model a vessel behind a dental implant. Cases in which both beam hardening and scatter were turned off, only scatter was turned on, only beam hardening was turned on, and both scatter and beam hardening were turned on, were simulated for both phantom models. The analysis of this data showed that the contrast degradation is primarily due to scatter. When analyzing the aneurysm case, 90.25% of the vessel contrast was lost in the polychromatic scatter image, however only 50.5% of the vessel contrast was lost in the beam hardening only image. When analyzing the teeth case, 44.2% of the vessel contrast was lost in the polychromatic scatter image and only 26.2% of the vessel contrast was lost in the beam hardening only image.

  11. Evening Primrose Oil Attenuates Certain Radiation Induced Functional and structural Disorders in Female Rats

    Directory of Open Access Journals (Sweden)

    Fatma, L.R. and Rezk R. G

    2004-09-01

    Full Text Available The aim of the present study was to evaluate the modulator role of evening primrose oil (EPO on the radiation induced changes in certain biochemical and histological abnormalities. Female rats were exposed to 5 Gy whole body -irradiation delivered as single dose. EPO was orally administrated to rats (9 ml/100g b.wt 7 days before irradiation exposure. Animals were sacrificed 1 day (oestrus stage, 6 days (one estrus cycle and 12 days (two estrus cycle after irradiation. The results obtained revealed that treatment with EPO diminished the increase in total cholesterol, urea and creatinine levels in plasma in comparison with the levels recorded in the plasma of irradiated rats. Significant amelioration of the radiation induced changes in RBC,s WBC,s count and the haemoglobin concentration, calcium level, FSH and LH hormones were also recorded in the plasma of EPO treated and irradiated rats. Histological observations of photomicrograph of kidney and ovary sections showed that irsaoiaun resulted in irradiation induced ruptured, dilated, haemorrhage glomerulei dissolution of the majority of primary follicles, and atrophy in ovary size. All these changes were obviously improved in animals supplied with EPO. It could be concluded that EPO could be useful adjunct for maintaining the integrity of biochemical functions and restoring the original histological architecture of kidney and ovary after irradiation.

  12. Effect on the insulation material of a MOSFET device submitted to a standard diagnostic radiation beam

    Energy Technology Data Exchange (ETDEWEB)

    De Magalhaes, C M S; Dos Santos, L A P; Souza, D do N; Maia, A F, E-mail: cinthiamsm@yahoo.com.b

    2010-11-01

    MOSFET electronic devices have been used for dosimetry in radiology and radiotherapy. Several communications show that due to the radiation exposure defects appear on the semiconductor crystal lattice. Actually, the structure of a MOSFET consists of three materials: a semiconductor, a metal and an insulator between them. The MOSFET is a quadripolar device with a common terminal: gate-source is the input; drain-source is the output. The gate controls the electrical current passing through semiconductor medium by the field effect because the silicon oxide acts as insulating material. The proposal of this work is to show some radiation effects on the insulator of a MOSFET device. A 6430 Keithley sub-femtoamp SourceMeter was used to verify how the insulating material layer in the structure of the device varies with the radiation exposure. We have used the IEC 61267 standard radiation X-ray beams generated from a Pantak industrial unit in the radiation energy range of computed tomography. This range was chosen because we are using the MOSFET device as radiation detector for dosimetry in computed tomography. The results showed that the behaviour of the electrical current of the device is different in the insulator and semiconductor structures.

  13. eBooking of beam-time over internet for beamlines of Indus synchrotron radiation sources

    International Nuclear Information System (INIS)

    Users from various research labs and academic institutes carry out experiments on beamlines of two Synchrotron Radiation Sources Indus-1 and Indus-2 available at RRCAT, Indore. To carry out experimental work on beamlines of both synchrotron radiation sources, beam-time is booked over Internet by the users of beamlines using user portal designed, developed and deployed over Internet. This portal has made the process of beamtime booking fast, hassle free and paperless as manual booking of beam-time for carrying out experiment on a particular beamline is cumbersome. The portal facilitates in-charge of Indus-1 and Indus-2 beamlines to keep track of users' records, work progress and other activities linked to experiments carried on beamlines. It is important to keep record and provide statistics about the usage of the beam lines from time-to-time. The user portal for e-booking of beam-time has been developed in-house using open source software development tools. Multi-step activities of users and beamline administrators are workflow based with seamless flow of information across various modules and fully authenticated using role based mechanism for different roles of software usage. The software is in regular use since November 2013 and has helped beamline in- charges in efficiently managing various activities related to user registration, booking of beam-time, booking of Guest House, Generation of Security permits, User feedback etc. Design concept, role based authentication mechanism and features provided by the web portal are discussed in detail in this paper. (author)

  14. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Gunther, Jillian R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sato, Mariko; Chintagumpala, Murali [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Ketonen, Leena [Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Jones, Jeremy Y. [Department of Pediatric Radiology, Texas Children' s Hospital, Houston, Texas (United States); Allen, Pamela K. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Paulino, Arnold C. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Okcu, M. Fatih; Su, Jack M. [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Weinberg, Jeffrey [Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Boehling, Nicholas S. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Khatua, Soumen [Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Adesina, Adekunle [Department of Pathology, Baylor College of Medicine, Texas Children' s Hospital, Houston, Texas (United States); Dauser, Robert; Whitehead, William E. [Department of Neurosurgery, Texas Children' s Hospital, Houston, Texas (United States); Mahajan, Anita, E-mail: amahajan@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2015-09-01

    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem.

  15. Attenuation measurements show that the presence of a TachoSil surgical patch will not compromise target irradiation in intra-operative electron radiation therapy or high-dose-rate brachytherapy

    International Nuclear Information System (INIS)

    Surgery of locally advanced and/or recurrent rectal cancer can be complemented with intra-operative electron radiation therapy (IOERT) to deliver a single dose of radiation directly to the unresectable margins, while sparing nearby sensitive organs/structures. Haemorrhages may occur and can affect the dose distribution, leading to an incorrect target irradiation. The TachoSil (TS) surgical patch, when activated, creates a fibrin clot at the surgical site to achieve haemostasis. The aim of this work was to determine the effect of TS on the dose distribution, and ascertain whether it could be used in combination with IOERT. This characterization was extended to include high dose rate (HDR) intraoperative brachytherapy, which is sometimes used at other institutions instead of IOERT. CT images of the TS patch were acquired for initial characterization. Dosimetric measurements were performed in a water tank phantom, using a conventional LINAC with a hard-docking system of cylindrical applicators. Percentage Depth Dose (PDD) curves were obtained, and measurements made at the depth of dose maximum for the three clinically used electron energies (6, 9 and 12MeV), first without any attenuator and then with the activated patch of TS completely covering the tip of the IOERT applicator. For HDR brachytherapy, a measurement setup was improvised using a solid water phantom and a Farmer ionization chamber. Our measurements show that the attenuation of a TachoSil patch is negligible, both for high energy electron beams (6 to 12MeV), and for a HDR 192Ir brachytherapy source. Our results cannot be extrapolated to lower beam energies such as 50 kVp X-rays, which are sometimes used for breast IORT. The TachoSil surgical patch can be used in IORT procedures using 6MeV electron energies or higher, or HDR 192Ir brachytherapy

  16. Improving the Fermilab Booster Notching Efficiency, Beam Losses and Radiation Levels

    Energy Technology Data Exchange (ETDEWEB)

    Rakhno, I.L.; Drozhdin, A.I.; Mokhov, N.V.; Sidorov, V.I.; Tropin, I.S.; /Fermilab

    2012-05-14

    A fast vertical 1.08-m long kicker (notcher) located in the Fermilab Booster Long-05 straight section is currently used to remove 3 out of 84 circulating bunches after injection to generate an abort gap. With the maximum magnetic field of 72.5 Gauss, it removes only 87% of the 3-bunch intensity at 400 MeV, with 75% loss on pole tips of the focusing Booster magnets, 11% on the Long-06 collimators, and 1% in the rest of the ring. We propose to improve the notching efficiency and reduce beam loss in the Booster by using three horizontal kickers in the Long-12 section. STRUCT calculations show that using horizontal notchers, one can remove up to 96% of the 3-bunch intensity at 400-700 MeV, directing 95% of it to a new beam dump at the Long-13 section. This fully decouples notching and collimation. The beam dump absorbs most of the impinging proton energy in its jaws. The latter are encapsulated into an appropriate radiation shielding that reduces impact on the machine components, personnel and environment to the tolerable levels. MARS simulations show that corresponding prompt and residual radiation levels can be reduced ten times compared to the current ones.

  17. Performance of a Roos ionization chamber in gamma radiation beams ({sup 60}Co)

    Energy Technology Data Exchange (ETDEWEB)

    Perini, Ana P.; Neves, Lucio P.; Caldas, Linda V.E., E-mail: lcaldas@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    Among the different types of dosimetry instruments, the ionization chambers are the most practical and and important radiation measurement devices due to their high sensitivity and relatively constant response within a wide range of energies. A commercial PTW ionization chamber (Roos electron chamber) usually utilized in X-ray beams, was tested to verify the possibility of its dosimetric application in {sup 60}Co beams. The main tests in this work were: short- and long-term stability, saturation, ion collection efficiency, polarity effect, leakage current and angular dependence. The characterization tests were performed using a Gammatron {sup 60}Co irradiator and a special goniometer made of PMMA. All results were within international recommendations. The reproducibility test presented results within the recommended limit of {+-}1%, and all coefficients of variation observed in the repeatability test were lower than {+-}0.07%. The ion collection efficiency was better than 99.9% for both polarities. For all pairs of polarity evaluated during the saturation test, the polarity effect was lower than the recommended limit. The maximum variation obtained for angular dependence test was only 0.5%. The chamber tested in this work achieved the expected results in the case of all pre-operational tests realized: stability, leakage current, angular dependence, saturation, ion collection and polarity effect. Evaluating the satisfactory results obtained, it is possible to indicate the usefulness of this ionization chamber for dosimetry in {sup 60}Co gamma radiation beams. (author)

  18. Intensity-Modulated Radiation Therapy with Noncoplanar Beams for Treatment of Prostate Cancer in Patients with Bilateral Hip Prosthesis-A Case Study

    International Nuclear Information System (INIS)

    Megavoltage photon intensity-modulated radiation therapy (IMRT) is typically used in the treatment of prostate cancer at our institution. Approximately 1% to 2% of patients with prostate cancer have hip prostheses. The presence of the prosthesis usually complicates the planning process because of dose perturbation around the prosthesis, radiation attenuation through the prosthesis, and the introduction of computed tomography artifacts in the planning volume. In addition, hip prostheses are typically made of materials of high atomic number, which add uncertainty to the dosimetry of the prostate and critical organs in the planning volume. When the prosthesis is bilateral, treatment planning is further complicated because only a limited number of beam angles can be used to avoid the prostheses. In this case study, we will report the observed advantages of using noncoplanar beams in the delivery of IMRT to a prostate cancer patient with bilateral hip prostheses. The treatment was planned for 75.6 Gy using a 7-field coplanar approach and a noncoplanar arrangement, with all fields avoiding entrance though the prostheses. Our results indicate that, compared with the coplanar plan, the noncoplanar plan delivers the prescribed dose to the target with a slightly better conformality and sparing of rectal tissue versus the coplanar plan.

  19. Two-parametric model of electron beam in computational dosimetry for radiation processing

    Science.gov (United States)

    Lazurik, V. M.; Lazurik, V. T.; Popov, G.; Zimek, Z.

    2016-07-01

    Computer simulation of irradiation process of various materials with electron beam (EB) can be applied to correct and control the performances of radiation processing installations. Electron beam energy measurements methods are described in the international standards. The obtained results of measurements can be extended by implementation computational dosimetry. Authors have developed the computational method for determination of EB energy on the base of two-parametric fitting of semi-empirical model for the depth dose distribution initiated by mono-energetic electron beam. The analysis of number experiments show that described method can effectively consider random displacements arising from the use of aluminum wedge with a continuous strip of dosimetric film and minimize the magnitude uncertainty value of the electron energy evaluation, calculated from the experimental data. Two-parametric fitting method is proposed for determination of the electron beam model parameters. These model parameters are as follow: E0 - energy mono-energetic and mono-directional electron source, X0 - the thickness of the aluminum layer, located in front of irradiated object. That allows obtain baseline data related to the characteristic of the electron beam, which can be later on applied for computer modeling of the irradiation process. Model parameters which are defined in the international standards (like Ep- the most probably energy and Rp - practical range) can be linked with characteristics of two-parametric model (E0, X0), which allows to simulate the electron irradiation process. The obtained data from semi-empirical model were checked together with the set of experimental results. The proposed two-parametric model for electron beam energy evaluation and estimation of accuracy for computational dosimetry methods on the base of developed model are discussed.

  20. The attenuation effect of UVc radiation doses in gram-negative bacteria (Brucella, Yersinia, Escherichia coli)

    International Nuclear Information System (INIS)

    The gram-negative bacteria Yersinia enterocolitica sero group O:3 and O:9, and Brucella (Melitensis and abortus) together with Escherichia coli (O:157, DH5α-pEt15b), were investigated to evaluate their susceptibility to UV radiation at 254 nm. If the dose of UVc was 18.7 mW/cm2, the time required for inactivation of Y. enterocolitica and E. coli DH5α-pEt15b and O:157 was 240s and 360s in the dark and light respectively; where if the dose was 19.5 mW/cm2, the time required was 60s in the dark and 120s in light respectively. The time required for inactivation of Brucella strains (melitensis and abortus) if the dose was 18.7 mW/cm2 was 240s in both dark and light, whereas it was 120s(dark) and 240s (light) respectively, when the dose was 19.5 mW/cm2. Using E. coli O:157 as control, it appears that Y. enterocolitica sero group O:3 and O:9 and vaccinal strains of Brucella (Rev. 1 and S19) are more sensitive to UV than wild Brucella strains. No relation was found between the sensitivity of Y. enterocolitica to UV and the presence or absence of a pYV+ virulence plasmid. (author)

  1. Radiation Resistance testing of commercial components for the new SPS Beam Position Measurement System

    CERN Document Server

    Deplano, C; Bogey, T; Gonzalez, J L; Savioz, J J

    2013-01-01

    A new Front-End (FE) electronics is under development for the SPS Multi Orbit POsition System (MOPOS). To cover the large dynamic range of beam intensities (70 dB) to be measured in the SPS, the beam position monitor signals are processed using logarithmic amplifiers. They are then digitized locally and transmitted via optical fibers over long distances (up to 1 km) to VME acquisition boards located in surface buildings. The FE board is designed to be located in the SPS tunnel, where it must withstand radiation doses of up to 100 Gy per year. Analogue components, such as Logarithmic Amplifiers (LA), ADC-Drivers (ADC-D) and Voltage Regulators (VR), have been tested at PSI (Paul Scherrer Institute) for radiation hardness, while several families of bidirectional SFP, both single-fiber and double-fiber, have been tested at both PSI and CNRAD. This paper gives a description of the overall system architecture and presents the results of the radiation hardness tests in detail.

  2. The results of radiotherapy for T1 glottic cancers; influence of radiation beam energy.

    Directory of Open Access Journals (Sweden)

    Yamamoto M

    1999-04-01

    Full Text Available We analyzed the influence of various parameters on the results of radiotherapy for T1 glottic cancer by assessing the outcomes of 60 patients with this cancer who received definitive radiotherapy between 1985 and 1994. Seven patients were treated with a cobalt-60 unit, and the other 53 with a linear accelerator (26 patients at 3-MV, 10 at 6-MV, and 17 at 10-MV. Of the 17 patients treated at 10-MV, 4 also received part of their treatment with a cobalt-60 unit. The total radiation dose ranged from 56 Gy to 70 Gy (mean, 61 Gy. The total radiation dose of 51 patients (85% was 60 Gy. The factors found to influence local control were the strength of the radiation beam energy and whether or not there was gross tumor invasion of the anterior commissure. The local control rate was 71% in the patients treated with a 10-MV linear accelerator, 56% in those treated with a 6-MV linear accelerator and, 97% in those treated with a cobalt-60 unit or a 3-MV linear accelerator (P = 0.0173. The local control rate was 43% in the patients with gross anterior commissure invasion and 88% in those without (P = 0.0075. We conclude that low energy photon beams are more suitable for the treatment of early glottic cancers, especially if the lesion grossly invades the anterior commissure.

  3. Chromium Waste Treatment from Leather Manufacture Using Electron Beam Radiation Technic

    International Nuclear Information System (INIS)

    Leather manufacture chromium waste treatment using chemical methods have an essential disadvantage, because of the production of the secondary contamination of wastes and separated sediments used by reagents. Therefore, a new technique is needed to solve this problem. The aim of the research to learn the advantages of electron beam radiation for chromium waste treatment. Water radiolysis can be produced by the interaction between electron beam and water or liquid substances. This phenomenon produces many reducing agents and ions that could reduce chromium concentrations in the liquid waste. Ethyl alcohol as a scavenger was added in the waste samples, then the pH of varied from 1, 4, 8 to 12, then were irradiated. Irradiation were done by Electron Beam Machine with dose 15, 25, and 35 kGy. After irradiation, chromium concentration in the samples were analyzed by AAS and UV-vis spectrophotometer. The results had shown that chromium could be reduced by high dose electron beam. The optimum reduction of chromium was achieved at liquid waste pH 8 and irradiation dose 35 kGy. (author)

  4. A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Coupling beam angle optimization with dose optimization in intensity-modulated radiation therapy (IMRT) increases the size and complexity of an already large-scale combinatorial optimization problem. We have developed a novel algorithm, nested partitions (NP), that is capable of finding suitable beam angle sets by guiding the dose optimization process. NP is a metaheuristic that is flexible enough to guide the search of a heuristic or deterministic dose optimization algorithm. The NP method adaptively samples from the entire feasible region, or search space, and coordinates the sampling effort with a systematic partitioning of the feasible region at successive iterations, concentrating the search in promising subsets. We used a 'warm-start' approach by initiating NP with beam angle samples derived from an integer programming (IP) model. In this study, we describe our implementation of the NP framework with a commercial optimization algorithm. We compared the NP framework with equi-spaced beam angle selection, the IP method, greedy heuristic and random sampling heuristic methods. The results of the NP approach were evaluated using two clinical cases (head and neck and whole pelvis) involving the primary tumor and nodal volumes. Our results show that NP produces better quality solutions than the alternative considered methods

  5. A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

    Science.gov (United States)

    D'Souza, Warren D.; Zhang, Hao H.; Nazareth, Daryl P.; Shi, Leyuan; Meyer, Robert R.

    2008-06-01

    Coupling beam angle optimization with dose optimization in intensity-modulated radiation therapy (IMRT) increases the size and complexity of an already large-scale combinatorial optimization problem. We have developed a novel algorithm, nested partitions (NP), that is capable of finding suitable beam angle sets by guiding the dose optimization process. NP is a metaheuristic that is flexible enough to guide the search of a heuristic or deterministic dose optimization algorithm. The NP method adaptively samples from the entire feasible region, or search space, and coordinates the sampling effort with a systematic partitioning of the feasible region at successive iterations, concentrating the search in promising subsets. We used a 'warm-start' approach by initiating NP with beam angle samples derived from an integer programming (IP) model. In this study, we describe our implementation of the NP framework with a commercial optimization algorithm. We compared the NP framework with equi-spaced beam angle selection, the IP method, greedy heuristic and random sampling heuristic methods. The results of the NP approach were evaluated using two clinical cases (head and neck and whole pelvis) involving the primary tumor and nodal volumes. Our results show that NP produces better quality solutions than the alternative considered methods.

  6. Mission critical operation archiving system using a database for synchrotron radiation beam lines at the Photon Factory

    International Nuclear Information System (INIS)

    The mission critical operation archiving system has been designed and built using the Oracle database for the twenty-two synchrotron radiation beam lines at the 2.5 GeV positron storage ring at the Photon Factory, where X-ray/VUV synchrotron radiation experiments are simultaneously carried out. When any one of beam lines is malfunctioning, neither injecting the 2.5 GeV beam into the storage ring nor operation of the ring is allowed due to the radiation safety reason. The system is designed for critical operation of the synchrotron radiation beam lines to provide a quick recovery from a failure, allowing a long term operation. The system has real-time capability to automatically store the database with all possible operational events of all vacuum valves/shutters and safety interlock signals, and all static operational data, including the pressures of the beam lines and the storage ring, and related operational data which represent the physical behaviors of the beam lines. By retrieving any combination of operational data, the system allows to reproduce the physical behaviors that have occurred in the beam lines. The total number of items to be inspected by the system is over 40 million in order to obtain a correlation between the faulty component and other physical components that suggests the cause of the failure. With the aid of the system, the operator at the control room can easily determine the faulty component, and recover the accelerator component. (author)

  7. Inclined-incidence quasi-Fresnel lens for prefocusing of synchrotron radiation x-ray beams

    Science.gov (United States)

    Kagoshima, Yasushi; Takano, Hidekazu; Takeda, Shingo

    2012-10-01

    An inclined-incidence quasi-Fresnel lens made of acrylic resin has been developed for prefocusing in synchrotron radiation x-ray beamlines. By inclining the lens, the grating aspect ratio is large enough for x-ray use. As it operates in transmission mode with negligible beam deflection and offset, little additional equipment is needed to introduce it into existing beamlines. It is fabricated by sheet-press forming, enabling inexpensive mass production. The prototype was able to focus a 730-μm-wide beam to a width of 80 μm with a photon flux density gain of 5.6 at an x-ray energy of 10 keV.

  8. Improving precision and safety in the use of beam modifying devices in radiation therapy

    International Nuclear Information System (INIS)

    Reliable and safe implementation of beam modifying devices such as wedges and block trays requires careful design and construction. Inappropriate design may pose problems ranging from user-hostile operation to hard-to-track, but significant variations in actual position in a beam. This may cause variation in actual wedge output factors, or variation in the position of a block tray. In case of simple mechanical failure or personnel mistake, design related mechanical conditions may result in injury to either a patient or a staff member. This paper is based on experience with linear accelerators from one manufacturer, but similar conditions are likely to exist with other radiation machines. A simple technical modification is offered which improves both accuracy and reproducibility in the placement of wedge-type filters. For our machines the solution also provides improved safety in the use of both wedge trays and block trays

  9. Hydrogel wound dressing preparation at the laboratory scale by using electron beam and gamma radiation

    International Nuclear Information System (INIS)

    The present work describes the preparation of hydrogel based on cross-linked networks of poly (N-vinylpirrolidone), PVP, with polyethyleneglicol and agar with 90% water and PVP nancomposites with a synthetic nanoclay, Laponite XLG, for use as burn dressings. These systems were obtained in two ways: using gamma Co-60 and electron beam radiation. The gelation obtained dose was Dg= 1.72 kGy. The elastic modulus of hydrogel was independent of the method of irradiation. It was 0.39 MPa for the hydrogel irradiated with gamma Co-60 and 0.38 MPa for electron beam irradiation. The elastic modulus of the nanocomposite membrane was 1.25 MPa, three times higher. These results indicate that the PVP/Laponite XLG nanocomposite hydrogel membrane is the best choice for wound dressing applications due to its high water sorption capacity and its superior mechanical properties.

  10. Radiation-Induced Centers in Lead Silicate Glasses Irradiated by Stationary and Pulsed Electron Beams

    Science.gov (United States)

    Zhidkov, I. S.; Zatsepin, A. F.; Konev, S. F.; Cholakh, S. O.

    2015-08-01

    Radiation-induced centers formed in heavy flint glasses irradiated by electron beams are investigated by the methods of optical and EPR spectroscopy. It is revealed that stable and short-living optical absorption centers of close natures are formed under irradiation by fast electrons. A correlation is established between the stable optical absorption bands and the EPR signals interpreted as signals of the (Pb2+)/h+ hole centers. The shortliving color centers are formed due to short-term distortion of the O-Pb bonds, and the stable centers are formed due to the spatial separation, thermalization, and subsequent stabilization of excited electrons and holes in tails of the localized states. Irradiation by electron beams leads to a change in the spectral characteristics of the fundamental absorption edge and, in particular, of the Urbach energy that determines the degree of structural disorder.

  11. Particle in cell simulation of laser-accelerated proton beams for radiation therapy

    International Nuclear Information System (INIS)

    In this article we present the results of particle in cell (PIC) simulations of laser plasma interaction for proton acceleration for radiation therapy treatments. We show that under optimal interaction conditions protons can be accelerated up to relativistic energies of 300 MeV by a petawatt laser field. The proton acceleration is due to the dragging Coulomb force arising from charge separation induced by the ponderomotive pressure (light pressure) of high-intensity laser. The proton energy and phase space distribution functions obtained from the PIC simulations are used in the calculations of dose distributions using the GEANT Monte Carlo simulation code. Because of the broad energy and angular spectra of the protons, a compact particle selection and beam collimation system will be needed to generate small beams of polyenergetic protons for intensity modulated proton therapy

  12. Study of the properties of inverted liquid sugar processed with gamma radiation and electron beam

    International Nuclear Information System (INIS)

    Brazil occupies position of prominence in the sugar market and high consumption of this ingredient in the liquid form, in special for the beverages and food industries. The liquid sugar presents advantages in relation to the bulk granulated system such as easiness of the handling and dosage, reduced space for the storage, reduction of the losses, costs and hand of workmanship, improvement of the sanitizing and great possible variation in the ratios of different mixtures of sugars. The inverted liquid sugar is a solution of sucrose, glucose and fructose in water. This ingredient receives this name because during its production it has an inversion of the optic power of rotation of the solution. In the productive process of the inverted sugar some points occur that can generate contamination by microorganisms, so its become important the development of techniques that propitiate the efficient sanitizing of this raw material. This work aims at to consider two alternative techniques of microbiologic control: gamma radiation with source of cobalto-60 and radiation with electron beam. The study was lead in the doses of 5, 10, 20, 30 and 50 kGy. Concentration of sucrose presented in syrup decreased with the radiation indicating the scission of glycosidic linkage in addition with the glucose and fructose formation, generating the increase in solids soluble. The acid compounds formation occurred, confirmed by the reduction of pH, that it was proportional with the increase of the radiation dose. The biggest doses had provoked change of color in the syrup by the long molecular chain polymers formation. Viscosity in the samples processed by gamma radiation increased in relation to the control, indicating the prevalence of polymerization of molecules, whereas in the radiation with electron beam the polymerization was only observed in the sample that received the dose of 50 kGy, In the sensorial analysis, the judges had pointed significant difference (5%) in the flavor among

  13. A proposal for PET/MRI attenuation correction with μ-values measured using a fixed-position radiation source and MRI segmentation

    Energy Technology Data Exchange (ETDEWEB)

    Kawaguchi, Hiroshi, E-mail: kwgc@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Hirano, Yoshiyuki, E-mail: yhirano@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Yoshida, Eiji, E-mail: rush@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Kershaw, Jeff, E-mail: len@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Shiraishi, Takahiro, E-mail: tshira@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Suga, Mikio, E-mail: mikio.suga@faculty.chiba-u.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Engineering of Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Ikoma, Yoko, E-mail: ikoma@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Obata, Takayuki, E-mail: t_obata@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Ito, Hiroshi, E-mail: hito@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Yamaya, Taiga, E-mail: taiga@nirs.go.jp [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

    2014-01-11

    Several MRI-based attenuation correction methods have been reported for PET/MRI; these methods are expected to make efficient use of high-quality anatomical MRIs and reduce the radiation dose for PET/MRI scanning. The accuracy of the attenuation map (μ-map) from an MRI depends on the accuracy of tissue segmentation and the attenuation coefficients to be assigned (μ-values). In this study, we proposed an MRI-based μ-value estimation method with a non-rotational radiation source to construct a suitable μ-map for PET/MRI. The proposed method uses an accurately segmented tissue map, the partial path length of each tissue, and detected intensities of attenuated radiation from a fixed-position (rather than a rotating) radiation source to obtain the μ-map. We estimated the partial path length from a virtual blank scan of fixed-point radiation with the same scanner geometry using the known tissue map from MRI. The μ-values of every tissue were estimated by inverting a linear relationship involving the partial path lengths and measured radioactivity intensity. Validation of the proposed method was performed by calculating a fixed- point data set based upon real a real transmission scan. The root-mean-square error between the μ-values derived from a conventional transmission scan and those obtained with our proposed method were 2.4±1.4%, 17.4±9.1% and 6.6±4.3% for brain, bone and soft tissue other than brain, respectively. Although the error estimates for bone and soft tissue are not insignificant, the method we propose is able to estimate the brain μ-value accurately and it is this factor that most strongly affects the quantitative value of PET images because of the large volumetric ratio of the brain. -- Highlights: • An MRI-derived µ-map for the attenuation correction of PET images is proposed. • Method relies on segmentation of MRI and a fixed-point source transmission scan. • Tissue segmentation reduces the number of unknown µ-values. • Method

  14. Measurement of therapeutic photon beams-induced Cerenkov radiation generated in PMMA- and PS-based plastic optical fibers

    Science.gov (United States)

    Lee, Bongsoo; Shin, Sang Hun; Yoo, Wook Jae; Jang, Kyoung Won

    2016-07-01

    In this study, we characterized Cerenkov radiation generated in polystyrene (PS)- and polymethyl methacrylate (PMMA)-based plastic optical fibers (POFs) to select an adequate optical fiber for producing Cerenkov radiation. To determine the relationship between the absorbed dose and the intensity of Cerenkov radiation, we calculated the energy depositions of photon beams and fluxes of electrons inducing Cerenkov radiation using the Monte Carlo N-Particle eXtended code. Also, intensities of Cerenkov radiation generated in PS- and PMMA-based POFs were measured as functions of dose rate and monitor unit. At last, therapeutic photon beams-induced Cerenkov radiation in PS- and PMMA-based POFs was measured according to depths of solid water phantom.

  15. Effect of Photon Beam Energy, Gold Nanoparticle Size and Concentration on the Dose Enhancement in Radiation Therapy

    Directory of Open Access Journals (Sweden)

    Nahideh Gharehaghaji

    2013-02-01

    Full Text Available Introduction: Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC simulation. Methods: We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanoparticles were simulated. The macroscopic dose enhancement factor was calculated for gold nanoparticles with sizes of 30, 50, and 100 nm. Also, we simulated different photon beams including mono-energetic beams (50-120 keV, a Cobalt-60 beam, 6 & 18 MV photon beams of a conventional linear accelerator. Results: We found a dose enhancement factor (DEF of from 1.4 to 3.7 for monoenergetic kilovoltage beams, while the DEFs for megavoltage beams were negligible and less than 3% for all GNP sizes and concentrations. The optimum energy for higher DEF was found to be the 90 keV monoenergetic beam. The effect of GNP size was not considerable, but the GNP concentration had a substantial impact on achieved DEF in GNP-based radiation therapy. Conclusion: The results were in close agreement with some previous studies considering the effect of photon energy and GNP concentration on observed DEF. Application of GNP-based radiation therapy using kilovoltage beams is recommended.

  16. A study on beams passing through hip prosthesis for pelvic radiation treatment

    International Nuclear Information System (INIS)

    Purpose: To study the dose distributions at the interface due to the presence of a metal implant; to show the dose distributions in combined fields in the presence of hip prostheses; and to demonstrate the capabilities and limitations of a conventional system. Methods and Materials: Perturbations in the dose distribution caused by a hip prosthesis can result in unacceptable dose inhomogeneities within the target volume and in regions where tissues interface with implant. The Monte Carlo technique and a conventional treatment planning system are used to calculate the dose distributions. Results: Dose increases of 15% in tissue are seen at the interface between metal implant and tissue. Dose reductions of 5-25% or 10-45% are observed in the shadow of the hip prosthesis made of 0.5-3-cm-thick titanium or steel alloy respectively. We compared predicted dose distribution between the Monte Carlo simulation and a commercial treatment planning system (CADPLAN). We found that CADPLAN underestimated the attenuation of hip prostheses. This has led to overestimation of the target dose by 14% for a typical four-field box technique. Conclusions: An acceptable dose distribution can be achieved with a proper lateral beam weighting and compensation using an eight-field technique. The beam compensation may be applied to achieve an adequate target dose

  17. Finite element analysis on electron beam brazing temperature and stresses of stainless steel radiator

    Institute of Scientific and Technical Information of China (English)

    Chen Furong; Liu Jun; Xie Ruijun; Liu Fangjun; Hu Gang

    2006-01-01

    Based on thermal-elasto-plastic finite element theory, a two-dimensional finite element model for calculating electron beam brazing temperature and residual stress fields of stainless steel radiator are presented.The distributions of temperature and residual stress are studied.The results showed that temperature distribution on brazing surface is rather uniform, ranging from 1026 ℃ to 1090 ℃.The residual stresses are varied from initial compressive to tensile , and the variation of residual stress is very little in total zone of brazing surface.

  18. Tailoring of Highly Intense THz Radiation Through High Brightness Electron Beams Longitudinal Manipulation

    Directory of Open Access Journals (Sweden)

    Flavio Giorgianni

    2016-02-01

    Full Text Available The ultra-short electron beams, produced through the velocity bunching compression technique at the SPARC_LAB test Facility (Frascati, Italy, are used to produce Coherent Transition Radiation in the terahertz (THz range. This paper reports on the main features of this THz source, which have a spectral coverage up to 5 THz, a pulse duration down to 100 fs, and an energy per pulse on the order of tens of μJ. These figures of merits open the possibility to apply this source for nonlinear and THz pump-probe experiments in Solid-State Physics and material science.

  19. Microwave radiation power of relativistic electron beam with virtual cathode in the external magnetic field

    Science.gov (United States)

    Kurkin, S. A.; Hramov, A. E.; Koronovskii, A. A.

    2013-07-01

    The study of the output power of the electromagnetic radiation of the relativistic electron beam (REB) with virtual cathode in the presence of external magnetic field has been found out. The typical dependencies of the output microwave power of the vircator versus external magnetic field have been analyzed by means of 3D electromagnetic simulation. It has been shown that the power of vircator demonstrates several maxima with external magnetic field growth. The characteristic features of the power behavior are determined by the conditions of the virtual cathode formation in the presence of the external transversal magnetic field and the REB self-magnetic fields.

  20. Microwave radiation power of relativistic electron beam with virtual cathode in the external magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Kurkin, S. A.; Hramov, A. E.; Koronovskii, A. A. [Saratov State University, Astrakhanskaja 83, Saratov 410012 (Russian Federation); Saratov State Technical University, Politechnicheskaja 77, Saratov 410028 (Russian Federation)

    2013-07-22

    The study of the output power of the electromagnetic radiation of the relativistic electron beam (REB) with virtual cathode in the presence of external magnetic field has been found out. The typical dependencies of the output microwave power of the vircator versus external magnetic field have been analyzed by means of 3D electromagnetic simulation. It has been shown that the power of vircator demonstrates several maxima with external magnetic field growth. The characteristic features of the power behavior are determined by the conditions of the virtual cathode formation in the presence of the external transversal magnetic field and the REB self-magnetic fields.

  1. RADIATION DOSIMETRY AT THE BNL HIGH FLUX BEAM REACTOR AND MEDICAL RESEARCH REACTOR.

    Energy Technology Data Exchange (ETDEWEB)

    HOLDEN,N.E.

    1999-09-10

    RADIATION DOSIMETRY MEASUREMENTS HAVE BEEN PERFORMED OVER A PERIOD OF MANY YEARS AT THE HIGH FLUX BEAM REACTOR (HFBR) AND THE MEDICAL RESEARCH REACTOR (BMRR) AT BROOKHAVEN NATIONAL LABORATORY TO PROVIDE INFORMATION ON THE ENERGY DISTRIBUTION OF THE NEUTRON FLUX, NEUTRON DOSE RATES, GAMMA-RAY FLUXES AND GAMMA-RAY DOSE RATES. THE MCNP PARTICLE TRANSPORT CODE PROVIDED MONTE CARLO RESULTS TO COMPARE WITH VARIOUS DOSIMETRY MEASUREMENTS PERFORMED AT THE EXPERIMENTAL PORTS, AT THE TREATMENT ROOMS AND IN THE THIMBLES AT BOTH HFBR AND BMRR.

  2. Noncoplanar Beam Angle Class Solutions to Replace Time-Consuming Patient-Specific Beam Angle Optimization in Robotic Prostate Stereotactic Body Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Linda, E-mail: l.rossi@erasmusmc.nl; Breedveld, Sebastiaan; Aluwini, Shafak; Heijmen, Ben

    2015-07-15

    Purpose: To investigate development of a recipe for the creation of a beam angle class solution (CS) for noncoplanar prostate stereotactic body radiation therapy to replace time-consuming individualized beam angle selection (iBAS) without significant loss in plan quality, using the in-house “Erasmus-iCycle” optimizer for fully automated beam profile optimization and iBAS. Methods and Materials: For 30 patients, Erasmus-iCycle was first used to generate 15-, 20-, and 25-beam iBAS plans for a CyberKnife equipped with a multileaf collimator. With these plans, 6 recipes for creation of beam angle CSs were investigated. Plans of 10 patients were used to create CSs based on the recipes, and the other 20 to independently test them. For these tests, Erasmus-iCycle was also used to generate intensity modulated radiation therapy plans for the fixed CS beam setups. Results: Of the tested recipes for CS creation, only 1 resulted in 15-, 20-, and 25-beam noncoplanar CSs without plan deterioration compared with iBAS. For the patient group, mean differences in rectum D{sub 1cc}, V{sub 60GyEq}, V{sub 40GyEq}, and D{sub mean} between 25-beam CS plans and 25-beam plans generated with iBAS were 0.2 ± 0.4 Gy, 0.1% ± 0.2%, 0.2% ± 0.3%, and 0.1 ± 0.2 Gy, respectively. Differences between 15- and 20-beam CS and iBAS plans were also negligible. Plan quality for CS plans relative to iBAS plans was also preserved when narrower planning target volume margins were arranged and when planning target volume dose inhomogeneity was decreased. Using a CS instead of iBAS reduced the computation time by a factor of 14 to 25, mainly depending on beam number, without loss in plan quality. Conclusions: A recipe for creation of robust beam angle CSs for robotic prostate stereotactic body radiation therapy has been developed. Compared with iBAS, computation times decreased by a factor 14 to 25. The use of a CS may avoid long planning times without losses in plan quality.

  3. Influence of nuclear radiation and laser beams on optical fibers and components

    Directory of Open Access Journals (Sweden)

    Pantelić Slađana N.

    2011-01-01

    Full Text Available The influence of nuclear radiation and particles has been the object of investigation for a long time. For new materials and systems the research should be continued. Human activities in various environments, including space, call for more detailed research. The role of fibers in contemporary communications, medicine, and industry increases. Fibers, their connections and fused optics components have one type of tasks - the transmission of information and power. The other type of tasks is reserved for fiber lasers: quantum generators and amplifiers. The third type of tasks is for fiber sensors, including high energy nuclear physics. In this paper we present some chosen topics in the mentioned areas as well as our experiments with nuclear radiation and laser beams to fiber and bulk materials of various nature (glass, polymer, metallic, etc..

  4. Preparation and characterization of polyethylene glycol diacrylate microgels using electron beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hamzah, Mohd Yusof [Makmal Nanoteknologi, Bahagian Teknologi Sinaran (Malaysia); Isa, Naurah Mat; Napia, Liyana M. Ali [ALURTRON, Bahagian Kemudahan Iradiasi, Malaysian Nuclear Agency, 43000, Kajang, Selangor (Malaysia)

    2014-02-12

    The use of microemulsion in the development of nanosized gels based on polyethylene glycol diacrylate (PEGDA) is demonstrated. PEGDA was solubilized in n-heptane with use of sodium docusate (AOT) at 0.15M concentration to form reverse micelles. These micelles were than irradiated at 5, 10, 15, 20 and 25 kGy using electron beam (EB) to crosslink the entrapped polymer in the micelles. Ionizing radiation was imparted to the emulsions to generate crosslinking reaction in the micelles formed. The nanosized gels were evaluated in terms of particle diameter using dynamic light scattering (DLS) and the images of the nanosized gels were studied using transmission electron microscopy (TEM). Results show that the size and shape of the particles are influenced by concentration of PEGDA and radiation dose. This study showed that this method can be utilized to produce nanosized gels.

  5. Absolute power scaling measurements of Electromagnetic radiation at 2ω /sub uh/ generated by steady state colliding electron beams

    International Nuclear Information System (INIS)

    Space physics data indicate Electromagnetic (EM) emission correlated with the existence of electron beams in solar and planetary sources. The EM power is too large to be produced by linear plasma production mechanisms, suggesting that non-linear beam processes can coherently, enhance the generation of EM radiation. Steady state counterstreaming electron beams are produced in a triple plasma device, where they collide in a filament discharge target plasma. Neutral pressure is low (5 x 10-5 Torr), with background target density, n /sub e/ less than or equal to 1010 cm-3 and electron temperature T /sub e/ less than or equal to 4 eV . Beams are grid extracted from sources and collimated with a small axial magnetic field (B /sub o/ less than or equal to 10 Gauss). Beam density is n /sub b/ less than or equal to 108 cm-3 and beam energy is E /sub b/ < 150 eV. Plasma ions with varying masses such as He+, Ar+, Xe+ are used. Diagnostics are carried out with electrostatic probes and absolutely calibrated single turn Faraday shielded loop antennae. When counterstreaming electron beams are allowed to collide in the target, steady state electrostatic and electromagnetic disturbances are observed respectively at the upper hybrid frequency and the first harmonic. The colliding beam EM radiation power is seen to be greatly enhanced over that of the single beam case

  6. Effects of electron-beam radiation on nutritional parameters of Portuguese chestnuts (Castanea sativa Mill.).

    Science.gov (United States)

    Carocho, Márcio; Barreira, João C M; Antonio, Amilcar L; Bento, Albino; Kaluska, Iwona; Ferreira, Isabel C F R

    2012-08-01

    Chestnuts are a widely consumed fruit around the world, with Portugal being the fourth biggest producer in Europe. Storage of these nuts is an important step during processing, and the most widely used fumigant was banned in the European Union under the Montreal Protocol because of its toxicity. Recently, radiation has been introduced as a cheap and clean conservation method. Previous studies of our research group proved that γ radiation had no negative effect on the nutritional value of chestnuts; in fact, storage time had a much bigger influence on the chestnut quality. In the present study, we report the effect of a less ionizing radiation, electron beam, with doses of 0, 0.5, 1, 3, and 6 kGy in the nutritional value of chestnuts (ash, energy, fatty acids, sugars, and tocopherols), previously stored at 4 °C for 0, 30, and 60 days. The storage time seemed to reduce fat and energetic values but reported a tendency for higher values of dry matter. With regard to fatty acids, there was a higher detected quantity of C20:2 in non-irradiated samples and four fatty acids were only detected in trace quantities (C6:0, C8:0, C10:0, and C12:0). γ-Tocopherol decreased during storage time but did not alter its quantity for all of the radiation doses (as like α-, β-, and δ-tocopherol); in fact, these compounds were present in higher concentrations in the irradiated samples. Sucrose and total sugars were lower in non-irradiated samples, and raffinose was only detected in irradiated samples. Electron-beam irradiation seems to be a suitable methodology, because the effects on chemical and nutritional composition are very low, while storage time seems to be quite important in chestnut deterioration.

  7. One-dimensional carbon nanostructures for terahertz electron-beam radiation

    Science.gov (United States)

    Tantiwanichapan, Khwanchai; Swan, Anna K.; Paiella, Roberto

    2016-06-01

    One-dimensional carbon nanostructures such as nanotubes and nanoribbons can feature near-ballistic electronic transport over micron-scale distances even at room temperature. As a result, these materials provide a uniquely suited solid-state platform for radiation mechanisms that so far have been the exclusive domain of electron beams in vacuum. Here we consider the generation of terahertz light based on two such mechanisms, namely, the emission of cyclotronlike radiation in a sinusoidally corrugated nanowire (where periodic angular motion is produced by the mechanical corrugation rather than an externally applied magnetic field), and the Smith-Purcell effect in a rectilinear nanowire over a dielectric grating. In both cases, the radiation properties of the individual charge carriers are investigated via full-wave electrodynamic simulations, including dephasing effects caused by carrier collisions. The overall light output is then computed with a standard model of charge transport for two particularly suitable types of carbon nanostructures, i.e., zigzag graphene nanoribbons and armchair single-wall nanotubes. Relatively sharp emission peaks at geometrically tunable terahertz frequencies are obtained in each case. The corresponding output powers are experimentally accessible even with individual nanowires, and can be scaled to technologically significant levels using array configurations. These radiation mechanisms therefore represent a promising paradigm for light emission in condensed matter, which may find important applications in nanoelectronics and terahertz photonics.

  8. Physiologically gated micro-beam radiation therapy using electronically controlled field emission x-ray source array

    Science.gov (United States)

    Chtcheprov, Pavel; Hadsell, Michael; Burk, Laurel; Ger, Rachel; Zhang, Lei; Yuan, Hong; Lee, Yueh Z.; Chang, Sha; Lu, Jianping; Zhou, Otto

    2013-03-01

    Micro-beam radiation therapy (MRT) uses parallel planes of high dose narrow (10-100 um in width) radiation beams separated by a fraction of a millimeter to treat cancerous tumors. This experimental therapy method based on synchrotron radiation has been shown to spare normal tissue at up to 1000Gy of entrance dose while still being effective in tumor eradication and extending the lifetime of tumor-bearing small animal models. Motion during the treatment can result in significant movement of micro beam positions resulting in broader beam width and lower peak to valley dose ratio (PVDR), and thus can reduce the effectiveness of the MRT. Recently we have developed the first bench-top image guided MRT system for small animal treatment using a high powered carbon nanotube (CNT) x-ray source array. The CNT field emission x-ray source can be electronically synchronized to an external triggering signal to enable physiologically gated firing of x-ray radiation to minimize motion blurring. Here we report the results of phantom study of respiratory gated MRT. A simulation of mouse breathing was performed using a servo motor. Preliminary results show that without gating the micro beam full width at tenth maximum (FWTM) can increase by 70% and PVDR can decrease up to 50%. But with proper gating, both the beam width and PVDR changes can be negligible. Future experiments will involve irradiation of mouse models and comparing histology stains between the controls and the gated irradiation.

  9. Design of a synchrotron radiation detector for the test beam lines at the Superconducting Super Collider Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, R.D.

    1994-01-01

    As part of the particle- and momentum-tagging instrumentation required for the test beam lines of the Superconducting Super Collider (SSC), the synchrotron radiation detector (SRD) was designed to provide electron tagging at momentum above 75 GeV. In a parallel effort to the three test beam lines at the SSC, schedule demands required testing and calibration operations to be initiated at Fermilab. Synchrotron radiation detectors also were to be installed in the NM and MW beam lines at Femilab before the test beam lines at the SSC would become operational. The SRD is the last instrument in a series of three used in the SSC test beam fines. It follows a 20-m drift section of beam tube downstream of the last silicon strip detector. A bending dipole just in of the last silicon strip detector produces the synchrotron radiation that is detected in a 50-mm-square cross section NaI crystal. A secondary scintillator made of Bicron BC-400 plastic is used to discriminate whether it is synchrotron radiation or a stray particle that causes the triggering of the NaI crystal`s photo multiplier tube (PMT).

  10. Design of a synchrotron radiation detector for the test beam lines at the Superconducting Super Collider Laboratory

    International Nuclear Information System (INIS)

    As part of the particle- and momentum-tagging instrumentation required for the test beam lines of the Superconducting Super Collider (SSC), the synchrotron radiation detector (SRD) was designed to provide electron tagging at momentum above 75 GeV. In a parallel effort to the three test beam lines at the SSC, schedule demands required testing and calibration operations to be initiated at Fermilab. Synchrotron radiation detectors also were to be installed in the NM and MW beam lines at Femilab before the test beam lines at the SSC would become operational. The SRD is the last instrument in a series of three used in the SSC test beam fines. It follows a 20-m drift section of beam tube downstream of the last silicon strip detector. A bending dipole just in of the last silicon strip detector produces the synchrotron radiation that is detected in a 50-mm-square cross section NaI crystal. A secondary scintillator made of Bicron BC-400 plastic is used to discriminate whether it is synchrotron radiation or a stray particle that causes the triggering of the NaI crystal's photo multiplier tube (PMT)

  11. Modification of the Theory of Dual Radiation Action for attenuated fields. II. Application to the analysis of soft X-ray results

    International Nuclear Information System (INIS)

    A formalism developed in the first paper in this series, based on the generalized Theory of Dual Radiation Action, is applied to survival data for cells exposed to soft X rays. It is shown that, in contrast to previous published analyses, this formalism, modified to account for the attenuation of dose across the sensitive matrix of the cell, is fully consistent with the experimental results. The reasons for previous disagreements are discussed

  12. Measurement of transverse beam parameters at X-ray diagnostic beamlines in Indus-2 synchrotron radiation source

    International Nuclear Information System (INIS)

    Indus-2 is a 3rd generation synchrotron radiation source at RRCAT, Indore with 2.5 GeV energy and 200 mA beam current. The average beam sizes of electron beam are a few hundred micrometers (∼ 250 μn) in the transverse plane. In Indus-2, various types of diagnostic devices have been installed in the storage ring for the measurement of beam orbit, beam profile, beam current, tune etc. To further enhance the performance of the beam diagnostic system, two diagnostic beamlines have been designed and developed viz. X-ray diagnostic beamline (X-DBL) and visible diagnostic beamline (V- DBL). Beamline BL-24 at 10° port of bending magnet (DP-10) of Indus-2 storage ring has been developed as X-DBL. X-DBL is based on x-ray imaging (8-18 keV) with a pinhole array system. It is primarily used for beam size, beam emittance and beam position measurement. In X-ray diagnostic beamline a LabVIEW based graphical user interface (Gill) has been developed for online image processing and measurement of various beam parameters. Beamline is used routinely for the online measurements of beam sizes, beam emittance and beam stability. Measured data is analyzed to find changes in SR source point parameters under different conditions of the beam operation. In the present optics setting, typical measured beam size (RMS) is 440 ± 20 μnm horizontal and 55 ± 5 μm vertical, and correspondingly typical measured emittance is 155 ± 20 nm rad horizontal and 0.4 ± 0.05 nm rad vertical during the natural decay of beam current from 120 mA to 40 mA. Beam position remains stable within ± 20 μm horizontal and ± 15 μm vertical during the natural decay of beam current in Indus-2. Photon beam position (at 8 m from source point) remains stable within ± 20 μm during this natural decay of beam current. In this paper various measurement results of the beamline are described. (author)

  13. Transverse coherence properties of X-ray beams in third-generation synchrotron radiation sources

    CERN Document Server

    Geloni, Gianluca; Schneidmiller, Evgeni; Yurkov, Mikhail

    2008-01-01

    This article describes a complete theory of spatial coherence for undulator radiation sources. Current estimations of coherence properties often assume that undulator sources are quasi-homogeneous, like thermal sources, and rely on the application of the van Cittert-Zernike theorem for calculating the degree of transverse coherence. Such assumption is not adequate when treating third generation light sources, because the vertical(geometrical) emittance of the electron beam is comparable or even much smaller than the radiation wavelength in a very wide spectral interval that spans over four orders of magnitude (from 0.1 Angstrom up to 10^3 Angstrom). Sometimes, the so-called Gaussian-Schell model, that is widely used in statistical optics in the description of partially-coherent sources, is applied as an alternative to the quasi-homogeneous model. However, as we will demonstrate, this model fails to properly describe coherent properties of X-ray beams from non-homogeneous undulator sources. As a result, a more...

  14. Intraoperative Electron-Beam Radiation Therapy for Pediatric Ewing Sarcomas and Rhabdomyosarcomas: Long-Term Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Sole, Claudio V., E-mail: csole@iram.cl [Department of Radiation Oncology, Instituto de Radiomedicina, Santiago (Chile); School of Medicine, Complutense University, Madrid (Spain); Calvo, Felipe A. [School of Medicine, Complutense University, Madrid (Spain); Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Polo, Alfredo [Service of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid (Spain); Cambeiro, Mauricio [Service of Radiation Oncology, Clínica Universidad de Navarra, Pamplona (Spain); Gonzalez, Carmen [School of Medicine, Complutense University, Madrid (Spain); Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Desco, Manuel [School of Medicine, Complutense University, Madrid (Spain); Department of Experimental Surgery and Medicine, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Martinez-Monge, Rafael [Service of Radiation Oncology, Clínica Universidad de Navarra, Pamplona (Spain)

    2015-08-01

    Purpose: To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). Methods and Materials: Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 2012. Local control (LC), overall survival (OS), and disease-free survival were estimated using Kaplan-Meier methods. For survival outcomes, potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results: After a median follow-up of 72 months (range, 4-310 months), 10-year LC, disease-free survival, and OS was 74%, 57%, and 68%, respectively. In multivariate analysis after adjustment for other covariates, disease status (P=.04 and P=.05) and R1 margin status (P<.01 and P=.04) remained significantly associated with LC and OS. Nine patients (13%) reported severe chronic toxicity events (all grade 3). Conclusions: A multimodal IOERT-containing approach is a well-tolerated component of treatment for pediatric EWS and RMS patients, allowing reduction or substitution of external beam radiation exposure while maintaining high local control rates.

  15. Intraoperative Electron-Beam Radiation Therapy for Pediatric Ewing Sarcomas and Rhabdomyosarcomas: Long-Term Outcomes

    International Nuclear Information System (INIS)

    Purpose: To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). Methods and Materials: Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 2012. Local control (LC), overall survival (OS), and disease-free survival were estimated using Kaplan-Meier methods. For survival outcomes, potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results: After a median follow-up of 72 months (range, 4-310 months), 10-year LC, disease-free survival, and OS was 74%, 57%, and 68%, respectively. In multivariate analysis after adjustment for other covariates, disease status (P=.04 and P=.05) and R1 margin status (P<.01 and P=.04) remained significantly associated with LC and OS. Nine patients (13%) reported severe chronic toxicity events (all grade 3). Conclusions: A multimodal IOERT-containing approach is a well-tolerated component of treatment for pediatric EWS and RMS patients, allowing reduction or substitution of external beam radiation exposure while maintaining high local control rates

  16. Multichannel Data Acquisition System comparison for Quality Assurance in external beam radiation therapy

    International Nuclear Information System (INIS)

    Megavoltage photon radiation therapies are widely used in modern cancer treatment. The improvement of the treatment has lead to the need of Quality Assurance (QA) devices to detect malfunctioning or human mistakes during the planning phase and treatment verification. Active electronic devices for 2D or 3D QA in external beam radiotherapy are typically based on analogue/digital mixed signal Data Acquisition Systems (DAS) which are required to have high spatial resolution, large dynamic range, high sensitivity, large numbers of channels and fast real-time capabilities. The Centre of Medical Radiation Physics (CMRP) has developed several multichannel DAS architectures based on different analogue front-ends to suit a wide range of radiotherapy applications. For the purpose of this study, two DAS, with different front-ends, have been equipped with 128 channels and tested in a clinical environment. Data show a good agreement within 1% between the two systems and the ionising chamber currently used for daily QA. - Highlights: • Two multichannels Data Acquisition Systems (DAS A and B) have been designed by the CMRP for Quality Assurance purposes. • The DAS have been tested and compared to ion chamber showing agreement of the results within 1%. • DAS have been used to characterise megavoltage LINAC beam profile and timing performances

  17. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    International Nuclear Information System (INIS)

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  18. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Do, Sharon [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Lum, Sharon; Garberoglio, Carlos [Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Mirshahidi, Hamid [Department of Medical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Patyal, Baldev; Grove, Roger; Slater, Jerry D. [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States)

    2014-11-01

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  19. Attenuation of Weather Radar Signals Due to Wetting of the Radome by Rainwater or Incomplete Filling of the Beam Volume

    Science.gov (United States)

    Merceret, Francis J.; Ward, Jennifer G.

    2000-01-01

    A search of scientific literature, both printed and electronic, was undertaken to provide quantitative estimates of attenuation effects of rainfall on weather radar radomes. The emphasis was on C-band (5 cm) and S-Band (10 cm) wavelengths. An empirical model was developed to estimate two-way wet radome losses as a function of frequency and rainfall rate for both standard and hydrophobic radomes. The model fits most of the published data within +/- 1 dB at both target wavelengths for rain rates from less than ten to more than 200 mm/hr. Rainfall attenuation effects remain under 1 dB at both frequencies regardless of radome type for rainfall rates up to 10 mm/hr. S-Band losses with a hydrophobic radome such as that on the WSR-88D remain under 1 dB up to 100 mm/hr. C-Band losses on standard radomes such as that on the Patrick AFB (Air Force Base) WSR-74C can reach as much as 5 dB at 50 mm/hr. In addition, calculations were performed to determine the reduction in effective reflectivity, Z, when a radar target is smaller than the sampling volume of the radar. Results are presented for both the Patrick Air Force Base WSR-74C and the WSR-88D as a function of target size and range.

  20. Beam test of novel n-in-p strip sensors for high radiation environment

    International Nuclear Information System (INIS)

    Highly radiation tolerant n-in-p strip sensors have been developed for the high-luminosity LHC (HL-LHC). This paper reports the results of measurements with 392 MeV kinetic energy proton beam at RCNP in December 2011. The data was taken with a new DAQ system consisting of an universal read-out board ‘SEABAS’ and beam tracking telescopes whose spacial resolution is better than 5μm. The aim of this beam test is to evaluate the new 1 cm×1 cm n-in-p miniature sensors before and after 1015 neq cm−2 irradiation. The median charge of un-irradiated sensor is 6.2 fC at full depletion voltage, while the median charge after 1015 neq cm−2 irradiation of the sensor is 4.2 fC. The novel Punch-Through-Protection (PTP) has been implemented in these sensors. The length of active region of the sensor around PTP is observed to be decreased by 12μm in the irradiated sensors at 1015 neq cm−2

  1. Radiation damage of semi-conductor device using micro ion-beam

    Energy Technology Data Exchange (ETDEWEB)

    Nishijima, Toshiji [Electrotechnical Lab., Tsukuba, Ibaraki (Japan)

    2001-02-01

    Ion beam induced charge collection (IBIC) analyzing method using fast micro ion-beam is a very useful technique for observation of interaction of fine solid materials for electronics with incident ions. This method is applied for development of semiconductor devices and investigation of single event upset phenomena (SEU) in an integrated circuit. To study on a basic process of the SEU, high energy ions are irradiated to the following three micro diode devices; silicon junction diode, silicon-on-insulator device (SOI), and SiC Schottky barrier diode. Transient currents induced in the micro diode devices by He{sup +} ion incidence of 2 MeV are measured through a charge sensitive preamplifier and a linear amplifier. The current signals are digitized by an analog to digital converter and measured by using a pulse height analyzer. The micro ion-beam are irradiated within the area of 10 {mu} m{sup 2} on the diode devices with 1-2 particles/ {mu} m{sup 2} by using the IBIC technique. Radiation damage of the diodes can be measured with the IBIC current pulse height. SiC Schottky barrier diode is unstable on the ion irradiation in comparison with Si junction diode and SOI junction diode. The SOI junction diode is stable within the range of irradiation rate, 3.7E+10 - 3.7E+12 ions/cm{sup 2}. (M. Suetake)

  2. Improving the Fermilab Booster Notching Efficiency, Beam Losses and Radiation Levels

    CERN Document Server

    Rakhno, I L; Mokhov, N V; Sidorov, V I; Tropin, I S

    2012-01-01

    Currently a fast vertical 1.08-m long kicker (notcher) located in the Fermilab Booster Long-5 straight section is used to remove 3 out of 84 circulating bunches after injection to generate an abort gap. With magnetic field of 72.5 Gauss it removes only 87% of the 3-bunch intensity at 400 MeV, with 75% loss on pole tips of the focusing Booster magnets, 11% on the Long-6 collimators, and 1% in the rest of the ring. We propose to improve the notching efficiency and reduce beam loss in the Booster by using two horizontal kickers in the Long-12 section. The STRUCT calculations show that using such horizontal notchers, one can remove up to 99% of the 3-bunch intensity at 400-700 MeV, directing 96% of it to a new beam dump at the Long-13 section. This fully decouples notching and collimation. The beam dump absorbs most of the impinging proton energy in its jaws. The latter are encapsulated into an appropriate radiation shielding that reduces impact on the machine components, personnel and environment to the tolerabl...

  3. Radiation environment simulations at the Tevatron, studies of the beam profile and measurement of the Bc meson mass

    Energy Technology Data Exchange (ETDEWEB)

    Nicolas, Ludovic Y.

    2005-09-01

    The description of a computer simulation of the CDF detector at Fermilab and the adjacent accelerator parts is detailed, with MARS calculations of the radiation background in various elements of the model due to the collision of beams and machine-related losses. Three components of beam halo formation are simulated for the determination of the principal source of radiation background in CDF due to beam losses. The effect of a collimator as a protection for the detector is studied. The simulation results are compared with data taken by a CDF group. Studies of a 150 GeV Tevatron proton beam are performed to investigate the transverse diffusion growth and distribution. A technique of collimator scan is used to scrape the beam under various experimental conditions, and computer programs are written for the beam reconstruction. An average beam halo growth speed is given and the potential of beam tail reconstruction using the collimator scan is evaluated. A particle physics analysis is conducted in order to detect the B{sub c} {yields} J/{psi}{pi} decay signal with the CDF Run II detector in 360 pb{sup -1} of data. The cut variables and an optimization method to determine their values are presented along with a criterion for the detection threshold of the signal. The mass of the B{sub c} meson is measured with an evaluation of the significance of the signal.

  4. The development and role of megavoltage cone beam computerized tomography in radiation oncology

    Science.gov (United States)

    Morin, Olivier

    External beam radiation therapy has now the ability to deliver doses that conform tightly to a tumor volume. The steep dose gradients planned in these treatments make it increasingly important to reproduce the patient position and anatomy at each treatment fraction. For this reason, considerable research now focuses on in-room three-dimensional imaging. This thesis describes the first clinical megavoltage cone beam computed tomography (MVCBCT) system, which utilizes a conventional linear accelerator equipped with an amorphous silicon flat panel detector. The document covers the system development and investigation of its clinical applications over the last 4-5 years. The physical performance of the system was evaluated and optimized for soft-tissue contrast resolution leading to recommendations of imaging protocols to use for specific clinical applications and body sites. MVCBCT images can resolve differences of 5% in electron density for a mean dose of 9 cGy. Hence, the image quality of this system is sufficient to differentiate some soft-tissue structures. The absolute positioning accuracy with MVCBCT is better than 1 mm. The accuracy of isodose lines calculated using MVCBCT images of head and neck patients is within 3% and 3 mm. The system shows excellent stability in image quality, CT# calibration, radiation exposure and absolute positioning over a period of 8 months. A procedure for MVCBCT quality assurance was developed. In our clinic, MVCBCT has been used to detect non rigid spinal cord distortions, to position a patient with a paraspinous tumor close to metallic hardware, to position prostate cancer patients using gold markers or soft-tissue landmarks, to monitor head and neck anatomical changes and their dosimetric consequences, and to complement the convention CT for treatment planning in presence of metallic implants. MVCBCT imaging is changing the clinical practice of our department by increasingly revealing patient-specific errors. New verification

  5. Radiation retinopathy after external-beam irradiation: Analysis of time-dose factors

    International Nuclear Information System (INIS)

    To investigate the risk of radiation-induced retinopathy according to total radiation dose and fraction size, based on both retorspective and prospectively collected data. Between October 1964 and May 1989, 68 retinae in 64 patients received fractionated external-beam irradiation during the treatment of primary extracranial head and neck tumors. All patients had a minimum of 3 years of ophthalmologic follow-up (range, 3 to 26 years; mean, 9 years; median, 8 years). Twenty-seven eyes in 26 patients developed radiation retinopathy resulting in visual acuity of 20/200 or worse. The mean and median times to the onset of symptoms attributable to retinal ischemia were 2.8 and 2.5 years, respectively. Fourteen of the injured eyes developed rubeosis iridis and/or neovascular glaucoma. Radiation retinopathy was not observed at doses below 45 Gy, but increased steadily in incidence at doses ≥45Gy. In the range of doses between 45 and 55 Gy, there was an increased risk of injury among patients who received doses per fraction of ≥1.9Gy (p - .09). There was also a trend toward increased risk of injury among patients who received chemotherapy (two of two vs. four of ten in the 45-51 Gy range; p - .23). The lowest dose associated with retinopathy was 45 Gy delivered to a diabetic patient by twice-a-day fractionation. The data did not suggest an increased risk of radiation retinopathy with increasing age. The current study suggests the importance of total dose as well as dose per fraction, and adds support to a small body of literature suggesting that patients with diabetes mellitus or who receive chemotherapy are at increased risk of injury. A sigmoid dose-response curve is constructed from our current data and data from the literature. 36 refs., 5 figs., 4 tabs

  6. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Depauw, Nicolas, E-mail: ndepauw@partners.org [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Batin, Estelle; Daartz, Julianne [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Rosenfeld, Anatoly [Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Adams, Judith; Kooy, Hanne; MacDonald, Shannon; Lu, Hsiao-Ming [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-02-01

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  7. Disinfection and reduction of organic load of sewage water by electron beam radiation

    Science.gov (United States)

    Maruthi, Y. Avasn; Das, N. Lakshmana; Hossain, Kaizar; Sarma, K. S. S.; Rawat, K. P.; Sabharwal, S.

    2011-09-01

    The efficacy of electron beam radiation for the disinfection and reduction of organic load of sewage water was assessed with ILU-6 Accelerator at Radiation Technology Development Division of the Bhabha Atomic Research Centre, Mumbai India. The current problem on environmental health in relation to water pollution insists for the safe disposal of sewage water. In general, sewage water comprises heterogeneous organic based chemicals as well as pathogens. EB treatment of the wastewater has found to be very effective in reducing the pathogens as well as organic load. EB dose of 1.5 kGy was sufficient for complete elimination of total coli forms. The experimental results elucidated the reduction of biological oxygen demand—BOD (35 and 51.7%) in both inlet and outlet sewage samples. Similarly reduction of chemical oxygen demand—COD was observed (37.54 and 52.32%) in both sewage samples with respect to increase in irradiation doses (0.45-6 kGy). The present study demonstrated the potential of ionizing radiation for disinfection of sewage and to increase the water quality of the wastewater by decreasing BOD and COD. So, the irradiation sewage water can find its application either in agriculture for irrigation, in industry for cooling purpose and some selected domestic purposes.

  8. Effect of radiation by electron beam on the mechanical properties of high density polyethylene

    International Nuclear Information System (INIS)

    In this work, the high density polyethylene (HDPE) was submitted to radiation doses ranging from 150 to 250 kGy in a 1.5 MeV electron accelerator, with purpose to evaluate the radiation dose effects on his mechanical properties. The irradiations were accomplished at 14 kGy/s dose, room temperature and presence of air. The material mechanical properties changes due to the irradiation were evaluated by means of traction and flexure resistance tests. The results presented a gain up to 150 % in the original rupture traction of the HDPE (not irradiated samples, gain up to 10 % in the percentage of maximum elongation in rupture for the irradiated samples, except for the 250 kGy, where no significant changes were observed (p < 0.05). The results also presented gains up to 20 % in the flexure resistance and losses of the order of 3 to 4 % in the traction resistance in the HDPE drainage related to the original, for the studied radiation dose interval (p <0.05). These results indicate that the irradiation by electron beam, at the conditions studied in this work, is a adequate d process for the modification of the HDPE mechanical properties, mainly for those applications requiring a high resistance to the traction solicitations

  9. Multiple scattering correction to measurement of beam attenuation in bubble wakes%气泡尾流光束衰减测量中的复散射校正

    Institute of Scientific and Technical Information of China (English)

    鲁刚; 孙春生; 张晓晖

    2012-01-01

    为了分析复散射对气泡尾流衰减测量的影响,采用小角度辐射传输方程,引入了表征复散射效应强弱的校正因子,通过数值求解分析了典型的尾流气泡尺度分布和数密度条件下复散射校正因子与接收视场角、光学厚度、光束大小和接收截面大小等参量之间的关系.结果表明,接收视场角在前向小角度范围内的变化对复散射校正因子的影响很大,而视场角较大时对复散射校正因子的影响基本相同;光学厚度的变化对复散射校正因子的影响显著,且在光学厚度小于1时,影响更明显;接收截面大小的变化在光学厚度小于1时对复散射校正因子的影响很小,但在光学厚度较大时,对复散射校正因子的影响比较明显;光束大小的变化对复散射因子的影响相对较小,且在光束束腰较大时对复散射因子的影响基本不变.该研究为尾流光束衰减测量条件的选择和优化提供了理论依据.%For analyzing the influence of multiple scattering on measuring beam attenuation in bubble wakes, the correction coefficient was introduced which denotes the extent of multiple scattering, and its theoretical formulations was derived by means of a narrow angle approximation solution to the radiation transfer equation. Given a typical bubbles size distribution function and number density in bubbles wakes, the relation among the correction coefficient and detector Geld of view ( FOV), wake optical depth, beam size, received section size were analyzed by numerical calculation. Analysis shows that the influence of FOV in forward small angle on the correction coefficient is great, but it has a little change when the FOV is wide; and the impact of optical depth on the correction coefficient is prominent, besides the impact is more prominent when the optical depth is less than 1; and the effect of received section size on the correction coefficient is very little when depth is less lhan 1, but it

  10. A novel diamond-based beam position monitoring system for the High Radiation to Materials facility at CERN SPS

    CERN Document Server

    AUTHOR|(CDS)2092886; Höglund, Carina

    The High Radiation to Materials facility employs a high intensity pulsed beam imposing several challenges on the beam position monitors. Diamond has been shown to be a resilient material with its radiation hardness and mechanical strength, while it is also simple due to its wide bandgap removing the need for doping. A new type of diamond based beam position monitor has been constructed, which includes a hole in the center of the diamond where the majority of the beam is intended to pass through. This increases the longevity of the detectors as well as allowing them to be used for high intensity beams. The purpose of this thesis is to evaluate the performance of the detectors in the High Radiation to Materials facility for various beam parameters, involving differences in position, size, bunch intensity and bunch number. A prestudy consisting of calibration of the detectors using single incident particles is also presented. The detectors are shown to work as intended after a recalibration of the algorithm, alb...

  11. Construction and performance test of radiation shielding for 300 keV/20 mA electron beam machine

    International Nuclear Information System (INIS)

    The construction and performance test of radiation shielding for 300 keV/20 mA electron beam machine (EBM) has been done. Radiation shielding is used for reduce X-ray radiation which is generated by operation of the EBM, so it is not harmful for people who work in that environment. Radiation shielding plates made of bars of lead (Pb) with a length of 135 cm, 10 cm of width, 2.5 cm of thick and composed a EBM radiation shielding. The plates are made of lead by way of casting and finished mechanically by machine, then installed manually on a frame to form a EBM radiation shielding. In the calculation of thick radiation shield already qualified dose rate limit is set by BAPETEN ≤ 2.5 mrem/hr. The results of the initial test radiation shielding is functioning, it is shown by the results of measurements of the maximum dose rate 0.26 mrem/hr at the operating conditions of EBM with voltage 209 kV and 50 mA of electron beam current. Based on the results test of the construction of radiation shielding are qualified dose rate limit set by BAPETEN. (author)

  12. Adaptive Radiation Therapy for Postprostatectomy Patients Using Real-Time Electromagnetic Target Motion Tracking During External Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: Using real-time electromagnetic (EM) transponder tracking data recorded by the Calypso 4D Localization System, we report inter- and intrafractional target motion of the prostate bed, describe a strategy to evaluate treatment adequacy in postprostatectomy patients receiving intensity modulated radiation therapy (IMRT), and propose an adaptive workflow. Methods and Materials: Tracking data recorded by Calypso EM transponders was analyzed for postprostatectomy patients that underwent step-and-shoot IMRT. Rigid target motion parameters during beam delivery were calculated from recorded transponder positions in 16 patients with rigid transponder geometry. The delivered doses to the clinical target volume (CTV) were estimated from the planned dose matrix and the target motion for the first 3, 5, 10, and all fractions. Treatment adequacy was determined by comparing the delivered minimum dose (Dmin) with the planned Dmin to the CTV. Treatments were considered adequate if the delivered CTV Dmin is at least 95% of the planned CTV Dmin. Results: Translational target motion was minimal for all 16 patients (mean: 0.02 cm; range: −0.12 cm to 0.07 cm). Rotational motion was patient-specific, and maximum pitch, yaw, and roll were 12.2, 4.1, and 10.5°, respectively. We observed inadequate treatments in 5 patients. In these treatments, we observed greater target rotations along with large distances between the CTV centroid and transponder centroid. The treatment adequacy from the initial 10 fractions successfully predicted the overall adequacy in 4 of 5 inadequate treatments and 10 of 11 adequate treatments. Conclusion: Target rotational motion could cause underdosage to partial volume of the postprostatectomy targets. Our adaptive treatment strategy is applicable to post-prostatectomy patients receiving IMRT to evaluate and improve radiation therapy delivery

  13. Adaptive Radiation Therapy for Postprostatectomy Patients Using Real-Time Electromagnetic Target Motion Tracking During External Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Mingyao [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States); Bharat, Shyam [Philips Research North America, Briarcliff Manor, New York (United States); Michalski, Jeff M.; Gay, Hiram A. [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States); Hou, Wei-Hsien [St Louis University School of Medicine, St Louis, Missouri (United States); Parikh, Parag J., E-mail: pparikh@radonc.wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States)

    2013-03-15

    Purpose: Using real-time electromagnetic (EM) transponder tracking data recorded by the Calypso 4D Localization System, we report inter- and intrafractional target motion of the prostate bed, describe a strategy to evaluate treatment adequacy in postprostatectomy patients receiving intensity modulated radiation therapy (IMRT), and propose an adaptive workflow. Methods and Materials: Tracking data recorded by Calypso EM transponders was analyzed for postprostatectomy patients that underwent step-and-shoot IMRT. Rigid target motion parameters during beam delivery were calculated from recorded transponder positions in 16 patients with rigid transponder geometry. The delivered doses to the clinical target volume (CTV) were estimated from the planned dose matrix and the target motion for the first 3, 5, 10, and all fractions. Treatment adequacy was determined by comparing the delivered minimum dose (D{sub min}) with the planned D{sub min} to the CTV. Treatments were considered adequate if the delivered CTV D{sub min} is at least 95% of the planned CTV D{sub min}. Results: Translational target motion was minimal for all 16 patients (mean: 0.02 cm; range: −0.12 cm to 0.07 cm). Rotational motion was patient-specific, and maximum pitch, yaw, and roll were 12.2, 4.1, and 10.5°, respectively. We observed inadequate treatments in 5 patients. In these treatments, we observed greater target rotations along with large distances between the CTV centroid and transponder centroid. The treatment adequacy from the initial 10 fractions successfully predicted the overall adequacy in 4 of 5 inadequate treatments and 10 of 11 adequate treatments. Conclusion: Target rotational motion could cause underdosage to partial volume of the postprostatectomy targets. Our adaptive treatment strategy is applicable to post-prostatectomy patients receiving IMRT to evaluate and improve radiation therapy delivery.

  14. Measurement of Cerenkov light in a fiber-optic radiation sensor by using high-energy photon and electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Kyoung Won; Cho, Dong Hyun; Yoo, Wook Jae; Seo, Jeong Ki; Heo, Ji Yeon; Lee, Bong Soo [Konkuk University, Chungju (Korea, Republic of); Cho, Young Ho [Catholic University, Daegu (Korea, Republic of); Park, Byung Gi [Soonchunhyang University, Asan (Korea, Republic of); Moon, Joo Hyun [Dongguk University, Gyeongju (Korea, Republic of); Kim, Sin [Cheju National University, Cheju (Korea, Republic of)

    2010-03-15

    In this study, we used a charge coupled device to measure scintillating and Cerenkov light generated in a scintillating fiber-optic radiation sensor irradiated by high-energy photon and electron beams. The intensities of Cerenkov light are measured and characterized as a function of the incident angles of the high-energy photon and electron beams from a clinical linear accelerator. To minimize or remove Cerenkov light, we investigated a subtraction method using a dummy optical fiber and a wavelength discrimination method using optical filters. Also, the intensities of Cerenkov light induced by high-energy photon and electron beams are compared.

  15. On the generation of supershort avalanche electron beams and x radiation during nanosecond discharges in dense gases (results and discussion)

    Science.gov (United States)

    Tarasenko, V. F.; Rybka, D. B.; Baksht, E. H.; Kostyrya, I. D.; Lomaev, M. I.

    2007-09-01

    Results of investigations of the generation of subnanosecond runaway electron beams and x radiation in gas diodes at elevated pressures are presented. The energy distributions of runaway electron beams generated in air at atmospheric pressure and the amplitude and duration of beam current pulses downstream of the foil have been measured, and also the mechanism of generation of a runaway electron beam has been analyzed. To record the beam current pulses, a collector which provided ˜50-ps time resolution and a Tektronix TDS6604 real-time oscilloscope were used in the experiment. It has been shown that the new experimental data and model predictions confirm in the main the results earlier obtained at the Institute of High Current Electronics of the Russian Academy of Sciences Siberian Division. Evidence is cited that the key statements of L. P. Babich are erroneous.

  16. Increasing Use of Dose-Escalated External Beam Radiation Therapy for Men With Nonmetastatic Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Swisher-McClure, Samuel, E-mail: Swisher-Mcclure@uphs.upenn.edu [Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (United States); Leonard Davis Institute of Health Economics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (United States); Mitra, Nandita; Woo, Kaitlin [Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Smaldone, Marc; Uzzo, Robert [Division of Urologic Oncology, Department of Surgery, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA (United States); Bekelman, Justin E. [Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (United States); Leonard Davis Institute of Health Economics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (United States); Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania (United States)

    2014-05-01

    Purpose: To examine recent practice patterns, using a large national cancer registry, to understand the extent to which dose-escalated external beam radiation therapy (EBRT) has been incorporated into routine clinical practice for men with prostate cancer. Methods and Materials: We conducted a retrospective observational cohort study using the National Cancer Data Base, a nationwide oncology outcomes database in the United States. We identified 98,755 men diagnosed with nonmetastatic prostate cancer between 2006 and 2011 who received definitive EBRT and classified patients into National Comprehensive Cancer Network (NCCN) risk groups. We defined dose-escalated EBRT as total prescribed dose of ≥75.6 Gy. Using multivariable logistic regression, we examined the association of patient, clinical, and demographic characteristics with the use of dose-escalated EBRT. Results: Overall, 81.6% of men received dose-escalated EBRT during the study period. The use of dose-escalated EBRT did not vary substantially by NCCN risk group. Use of dose-escalated EBRT increased from 70.7% of patients receiving treatment in 2006 to 89.8% of patients receiving treatment in 2011. On multivariable analysis, year of diagnosis and use of intensity modulated radiation therapy were significantly associated with receipt of dose-escalated EBRT. Conclusions: Our study results indicate that dose-escalated EBRT has been widely adopted by radiation oncologists treating prostate cancer in the United States. The proportion of patients receiving dose-escalated EBRT increased nearly 20% between 2006 and 2011. We observed high utilization rates of dose-escalated EBRT within all disease risk groups. Adoption of intensity modulated radiation therapy was strongly associated with use of dose-escalated treatment.

  17. Optimal beam design on intensity-modulated radiation therapy with simultaneous integrated boost in nasopharyngeal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Mei-Chun [Division of Radiation Oncology, Department of Oncology Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (China); Hu, Yu-Wen; Liu, Ching-Sheng [Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan (China); Lee, Jeun-Shenn [Division of Radiation Oncology, Department of Oncology Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Huang, Pin-I; Yen, Sang-Hue; Lee, Yuh-Lin; Hsieh, Chun-Mei [Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan (China); Shiau, Cheng-Ying, E-mail: cyshiau@vghtpe.gov.tw [Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan (China)

    2014-10-01

    This study aims to determine the optimal beam design among various combinations of field numbers and beam trajectories for intensity-modulated radiation therapy (IMRT) with simultaneous integrated boost (SIB) technique for the treatment of nasopharyngeal cancer (NPC). We used 10 fields with gantry angles of 155°, 130°, 75°, 25°, 0° L, 0° R, 335°, 285°, 230°, and 205° denoted as F10. To decrease doses in the spinal cord, the F10 technique was designed by featuring 2 pairs of split-opposed beam fields at 155° to 335° and 205° to 25°, as well as one pair of manually split beam fields at 0°. The F10 technique was compared with 4 other common field arrangements: F7E, 7 fields with 50° equally spaced gantry angles; F7, the basis of F10 with 155°, 130°, 75°, 0°, 285°, 230°, and 205°; F9E, 9 fields with 40° equally spaced gantry angles; and FP, 7 posterior fields with 180°, 150°, 120°, 90°, 270°, 240°, and 210°. For each individual case of 10 patients, the customized constraints derived after optimization with the standard F10 technique were applied to 4 other field arrangements. The 4 new optimized plans of each individual case were normalized to achieve the same coverage of planning target volume (PTV){sub 63} {sub Gy} as that of the standard F10 technique. The F10 field arrangement exhibited the best coverage in PTV{sub 70} {sub Gy} and the least mean dose in the trachea-esophagus region. Furthermore, the F10 field arrangement demonstrated the highest level of conformity in the low-dose region and the least monitor unit. The F10 field arrangement performed more outstandingly than the other field arrangements in PTV{sub 70} {sub Gy} coverage and spared the central organ. This arrangement also exhibited the highest conformity and delivery efficiency. The F10 technique is recommended as the standard beam geometry for the SIB-IMRT of NPC.

  18. High flux and high resolution VUV beam line for synchrotron radiation

    International Nuclear Information System (INIS)

    A beam line has been optimized for high flux and high resolution in the wavelength range from 30 nm to 300 nm. Sample chambers for luminescence spectroscopy on gaseous, liquid and solid samples and for photoelectron spectroscopy have been integrated. The synchrotron radiation from the storage ring DORIS (at DESY, Hamburg) emitted into 50 mrad in horizontal and into 2.2 mrad in vertical direction is focused by a cylindrical and a plane elliptical mirror into the entrance slit of a 2m normal incidence monochromator. The light flux from the exit slit is focused by a rotational elliptic mirror onto the sample yielding a size of the light spot of 4 x 0.15 mm2. The light flux at the sample reaches 7 x 1012 photons nm-1s-1 at 8 eV photon energy for a current of 100 mA in DORIS. A resolution of 0.007 nm has been obtained. (orig.)

  19. Polarized Uniform Linear Array System: Beam Radiation Pattern, Beamforming Diversity Order, and Channel Capacity

    Directory of Open Access Journals (Sweden)

    Xin Su

    2015-01-01

    Full Text Available There have been many studies regarding antenna polarization; however, there have been few publications on the analysis of the channel capacity for polarized antenna systems using the beamforming technique. According to Chung et al., the channel capacity is determined by the density of scatterers and the transmission power, which is obtained based on the assumption that scatterers are uniformly distributed on a 3D spherical scattering model. However, it contradicts the practical scenario, where scatterers may not be uniformly distributed under outdoor environment, and lacks the consideration of fading channel gain. In this study, we derive the channel capacity of polarized uniform linear array (PULA systems using the beamforming technique in a practical scattering environment. The results show that, for PULA systems, the channel capacity, which is boosted by beamforming diversity, can be determined using the channel gain, beam radiation pattern, and beamforming diversity order (BDO, where the BDO is dependent on the antenna characteristics and array configurations.

  20. Investigation of GEM-Micromegas Detector on X-ray Beam of Synchrotron Radiation

    CERN Document Server

    Zhang, YuLian; Hu, BiTao; Fan, ShengNan; Wang, Bo; Liu, Mei; Zhang, Jian; Liu, RongGuang; Chang, GuangCai; Liu, Peng; Ouyang, Qun; Chen, YuanBo; Yi, FuTing

    2013-01-01

    To solve the discharge of the standard Bulk Micromegas and GEM detector, the GEM-Micromegas detector was developed in Institute of High Energy Physics. Taking into account the advantages of the two detectors, one GEM foil was set as a preamplifier on the mesh of Micromegas in the structure and the GEM preamplification decreased the working voltage of Micromegas to reduce the effect of the discharge significantly. In the paper, the performance of detector in X-ray beam was studied at 1W2B laboratory of Beijing Synchrotron Radiation Facility. Finally, the result of the energy resolution under various X-ray energies was given in different working gases. It indicated that the GEM-Micromegas detector had the energy response capability in all the energy range and it could work better than the standard Bulk-Micromegas.

  1. Time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. (Argonne National Lab., IL (United States)); Wilke, M.D. (Los Alamos National Lab., NM (United States))

    1992-01-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.

  2. Time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. [Argonne National Lab., IL (United States); Wilke, M.D. [Los Alamos National Lab., NM (United States)

    1992-09-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.

  3. Further time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. (Argonne National Lab., IL (United States). Advanced Photon Source Accelerator Systems Div.); Wilke, M.D. (Los Alamos National Lab., NM (United States))

    1992-01-01

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 [mu]s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.

  4. Further time-resolved electron-beam characterizations with optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H. [Argonne National Lab., IL (United States). Advanced Photon Source Accelerator Systems Div.; Wilke, M.D. [Los Alamos National Lab., NM (United States)

    1992-12-31

    Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.

  5. Brain tumors and synchrotron radiation: new methods for mini-beams radiation therapy and treatment follow-up by functional imaging

    International Nuclear Information System (INIS)

    An innovative method of synchrotron radiation therapy, called mini-beams, was proposed by A. Dilmanian et al. in 2006. Mini-beams consists in tumor irradiation with monochromatic sub-millimetric x-ray beams spatially fractionated produced by a synchrotron source. To obtain a homogeneous dose in the target volume, an interleaving is realized using two orthogonal incidences. Adjacent healthy tissue is only partially irradiated by mini-beams, the areas between the beams only receive scattered radiation and therefore the energy deposited is 10 to 15 times lower than on one mini-beam axis, leading to a sparing effect of healthy tissue even when a high dose is deposited in the target volume. The thesis project is the development of this experimental method of monochromatic mini-beams, which involves the control of the irradiation geometry, the control of dosimetry and its modeling by Monte Carlo simulations. To evaluate the method, preclinical experiments on models of brain tumors implanted in rats (F98) are performed. Follow-up by anatomical and functional imaging is carried out to evaluate the effectiveness of the treatment. Functional imaging of cerebral perfusion (volume and cerebral blood flow, mean transit time of heavy elements) appears to be associated in the literature as a relevant method for monitoring prognostic. The key parameters of the cerebral vasculature are mainly studied in magnetic resonance imaging (MRI), because of the harmlessness of this imaging modality. The relation between MRI signal and contrast agent concentration is very complex and no quantitative relationship is well known. Synchrotron Radiation Computed Tomography (SRCT) is an imaging modality with performances to measure absolute contrast agent concentration very close to the theoretical limits and can be used as gold-standard. The used pharmacokinetic models need as input parameters a contrast agent concentration versus time. A comparison of perfusion measurements between MRI and SRCT

  6. Emission and propagation of Saturn kilometric radiation: Magnetoionic modes, beaming pattern, and polarization state

    Science.gov (United States)

    Lamy, L.; Cecconi, B.; Zarka, P.; Canu, P.; Schippers, P.; Kurth, W. S.; Mutel, R. L.; Gurnett, D. A.; Menietti, D.; Louarn, P.

    2011-04-01

    The Cassini mission crossed the source region of the Saturn kilometric radiation (SKR) on 17 October 2008. On this occasion, the Radio and Plasma Wave Science (RPWS) experiment detected both local and distant radio sources, while plasma parameters were measured in situ by the magnetometer and the Cassini Plasma Spectrometer. A goniopolarimetric inversion was applied to RPWS three-antenna electric measurements to determine the wave vector k and the complete state of polarization of detected waves. We identify broadband extraordinary (X) mode as well as narrowband ordinary (O) mode SKR at low frequencies. Within the source region, SKR is emitted just above the X mode cutoff frequency in a hot plasma, with a typical electron-to-wave energy conversion efficiency of ˜1% (2% peak). The knowledge of the k vector is then used to derive the locus of SKR sources in the kronian magnetosphere, which shows X and O components emanating from the same regions. We also compute the associated beaming angle at the source θ‧ = (k, -B) either from (1) in situ measurements or a model of the magnetic field vector (for local to distant sources) or (2) polarization measurements (for local sources). Obtained results, similar for both modes, suggest quasi-perpendicular emission for local sources, whereas the beaming pattern of distant sources appears as a hollow cone with a frequency-dependent constant aperture angle: θ‧ = 75° ± 15° below 300 kHz, decreasing at higher frequencies to reach θ‧ (1000 kHz) = 50° ± 25°. Finally, we investigate quantitatively the SKR polarization state, observed to be strongly elliptical at the source, and quasi-purely circular for sources located beyond approximately two kronian radii. We show that conditions of weak mode coupling are achieved along the raypath, under which the magnetoionic theory satisfactorily describes the evolution of the observed polarization. These results are analyzed comparatively with the auroral kilometric radiation at

  7. Incidence of primary hypothyroidism in patients exposed to therapeutic external beam radiation, where radiation portals include a part or whole of the thyroid gland

    Directory of Open Access Journals (Sweden)

    B A Laway

    2012-01-01

    Full Text Available Introduction: Hypothyroidism is a known consequence of external-beam radiotherapy to the neck encompassing a part or whole of the thyroid gland. In this non-randomized prospective study, we have tried to evaluate the response of the thyroid gland to radiation by assessing thyroid function before irradiation and at regular intervals after irradiation. Aims and Objectives: The aim of this study were to assess in the cancer patients, who were exposed to the therapeutic external beam radiation, where radiation portals include a part or whole of the thyroid gland: the incidence of primary hypothyroidism, the time required to become hypothyroid, any relation between the total dose for the development of hypothyroidism, and whether there are any patient or treatment-related factors that are predictive for the development of hypothyroidism, including the use of concurrent chemotherapy. Materials and Methods: This non-randomized, prospective study was conducted for a period of 2 years in which thyroid function was assessed in 59 patients (cases of head and neck cancer, breast cancer, lymphoma patients and other malignancies, who had received radiotherapy to the neck region. 59 euthyroid healthy patients (controls were also taken, who had not received the neck irradiation. These patients/controls were assessed periodically for 2 years. Results: The incidence of hypothyroidism after external beam radiation therapy (EBRT to neck where radiation portals include part or whole of the thyroid gland was 16.94%, seven cases had subclinical hypothyroidism (11.86% and three cases had clinical hypothyroidism (5.08%. Mean time for development of hypothyroidism was 4.5 months. There was no effect of age, gender, primary tumor site, radiation dose and chemotherapy, whether neoadjuvant or concurrent with the development of hypothyroidism. Conclusion: In summary, we found that thyroid dysfunction is a prevalent, yet easily treatable source of morbidity in patients

  8. The WebCam vs. the Particle Beam: A CRaTER Visualization of the Effects of Radiation

    Science.gov (United States)

    Case, A. W.; Gross, N. A.; Spence, H. E.

    2008-12-01

    The term "radiation" can cause significant anxiety to a general audience in part because of the associated health risks, but also because of lack of a conceptual framework about the nature of radiation. A visual depiction of radiation may go a long way towards providing just such a framework. The CRaTER Team had an opportunity to create just such a video. The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) is a radiation instrument that will fly on the Lunar Reconnaissance Orbiter (LRO) and is designed to determine the effects of energetic particles on living tissue. In order to calibrate CRaTER and characterize its reaction to various radiation environments, the CRaTER team has used particle beam facilities include the Proton Radiation Therapy Facility at Massachusetts General Hospital (MGH). During one of the sessions at MGH, the team placed an off the shelf web camera into the beam and recorded the visual effects. This video recording was used as the basis for an edited video describing what was done and the results. The hope is that this video will provide a general audience with a visual framework for the nature and effects of radiation

  9. Hypofractionated electron-beam radiation therapy for keloids. Retrospective study of 568 cases with 834 lesions

    International Nuclear Information System (INIS)

    We aimed to analyze the outcomes of hypofractionated high-energy electron beam radiotherapy for the treatment of keloids. From February 1998 to January 2012, 568 patients with a total of 834 keloids underwent radiotherapy: 826 lesions with postoperative radiotherapy, and 36 with skin-grafting. Lesion size was >5 cm in 335 keloids. An electron-beam of 6 or 7 MeV was used, with a total dose of 18 Gy (two fractions with a 1-week interval) covering the lesion with a 1-cm margin. The time between surgery and radiotherapy was 24–48 h. Skin-grafted patients underwent radiotherapy 10–15 days after the operation. The median follow-up was 40 months (range: 12–160 months). The local control rate was 88.25% (736/834). The relapse rate was 9.59% (80/834), and the time to relapse was 6–28 months (median: 12 months). Univariate analyses showed that gender, age, keloid size, keloid site, skin grafting, and operation-to-irradiation interval influenced the local control rate. Multivariate analysis showed that the relapse rate was correlated with gender (P = 0.048), age (P < 0.01), operation-to-irradiation interval (P < 0.01), keloid site (P < 0.01), surgical method (P = 0.04) and keloid size (P < 0.02). Adverse effects were observed in 9.83% (82/834). No radiation-induced cancers were observed. Hypofractionated high-energy electron beam radiotherapy for keloids yielded excellent outcomes, especially in cases without skin grafting. Early postoperative radiotherapy with limited hypofractionation could be a good choice for keloid treatment. (author)

  10. Molecular beam mass spectrometry with tunable vacuum ultraviolet (VUV) synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Golan, Amir; Ahmed, Musahid

    2012-01-01

    Tunable soft ionization coupled to mass spectroscopy is a powerful method to investigate isolated molecules, complexes and clusters and their spectroscopy and dynamics.[1-4] Fundamental studies of photoionization processes of biomolecules provide information about electronic structure of these systems. Furthermore determinations of ionization energies and other properties of biomolecules in the gas phase are not trivial, and these experiments provide a platform to generate these data. We have developed a thermal vaporization technique coupled with supersonic molecular beams that provides a gentle way to transport these species into the gas phase. Judicious combination of source gas and temperature allows for formation of dimers and higher clusters of the DNA bases. The focus of this particular work is on the effects of non-covalent interactions, i.e., hydrogen bonding, stacking, and electrostatic interactions, on the ionization energies and proton transfer of individual biomolecules, their complexes and upon micro-hydration by water.[1, 5-9] We have performed experimental and theoretical characterization of the photoionization dynamics of gas-phase uracil and 1,3-methyluracil dimers using molecular beams coupled with synchrotron radiation at the Chemical Dynamics Beamline[10] located at the Advanced Light Source and the experimental details are visualized here. This allowed us to observe the proton transfer in 1,3-dimethyluracil dimers, a system with pi stacking geometry and with no hydrogen bonds[1]. Molecular beams provide a very convenient and efficient way to isolate the sample of interest from environmental perturbations which in return allows accurate comparison with electronic structure calculations[11, 12]. By tuning the photon energy from the synchrotron, a photoionization efficiency (PIE) curve can be plotted which informs us about the cationic electronic states. These values can then be compared to theoretical models and calculations and in turn, explain

  11. Improvement of the fracture toughness matrix cured by electron beam radiation, by incorporation of thermoplastic

    International Nuclear Information System (INIS)

    The aim of the present study is to improve the fracture toughness of a vinyl-ester matrix cured by electron beam radiation, by incorporation of a thermoplastic polymer. The ultimate plan is to improve the fracture toughness of the composite material made of this reinforced matrix and carbon fibres. The first step deals with the study of an epoxy matrix reinforced by a polyether-sulfone. This well-known material, as it is used in industrial formulation, allowed us to characterize all the parameters needed to obtain a good reinforcement as for instance the morphology, and also to compare two kinds of processes: thermal and electron beam curing. In fact, we are really interested in increasing fracture toughness of a vinyl-ester matrix that is not miscible with polyether-sulfone. So a copolymer which has a similar structure as polyether-sulfone is synthesized in order to obtain a miscible blend. The corresponding material has good fracture toughness, with an increase of 80 % for 15 % addition of thermoplastic. (author)

  12. Dose Rate Effects on The Radiation Oxidation of Polyethylene: Electron Beam vs Gamma Irradiation

    International Nuclear Information System (INIS)

    The yields and spatial distribution of the oxidation products stemming from the oxidation of LLPE films induced by 60-Co gamma and by irradiation with 300 kev, 0.3 mA electrons in the dose range 0.04 kGy/h - 0.6 kGy/h (gamma) and at 1.5 kGy/hr ( e-beam) have been determined by applying a methodology involving FTIR microscopy (carbonyl products, resolution 10 μ), iodometric analysis (peroxides). The FTIR and EPR spectroscopies coupled with the multilayer technique (resolution 25 μ) were also employed for carrying on measurements of the film depth profiles of peroxyl radicals and their alky radicals precursors, radical decay kinetics, 'free' and ' bound' hydroperoxides and alcools. With gamma radiations the products yields are enhanced following the decrease of the dose rate from 0.7 to 0.04 kGy/h without substantial effect on the film depth distributions which appear rather uniform. Using e-beam (dose rate 1.5 kGy/h) a low level concentration limit is attained confined within the first 50 μ which is about 1 order of magnitude smaller as compared to gamma. The mechanistic implications inherent to the experimental results as well as the practical consequences related to the use of radiooxidation as a tool for inducing graft copolymerization reactions are discussed

  13. Impact of the Wiggler Coherent Synchrotron Radiation Impedance on the Beam Instability

    CERN Document Server

    Wu, J; Raubenheimer, T O; Huang, Z; Huang, Zhirong

    2003-01-01

    Coherent Synchrotron Radiation (CSR) can play an important role by not only increasing the energy spread and emittance of a beam, but also leading to a potential instability. Previous studies of the CSR induced longitudinal instability were carried out for the CSR impedance due to dipole magnets. However, many storage rings include long wigglers where a large fraction of the synchrotron radiation is emitted. This includes high-luminosity factories such as DAPHNE, PEP-II, KEK-B, and CESR-C as well as the damping rings of future linear colliders. In this paper, the instability due to the CSR impedance from a wiggler is studied assuming a large wiggler parameter $K$. The primary consideration is a low frequency microwave-like instability, which arises near the pipe cut-off frequency. Detailed results are presented on the growth rate and threshold for the damping rings of several linear collider designs. Finally, the optimization of the relative fraction of damping due to the wiggler systems is discussed for the ...

  14. Enhanced terahertz radiation from an elliptical-beam-illuminated sawtooth photoconductive antenna: design and numerical analysis

    CERN Document Server

    Zhang, Jitao

    2014-01-01

    The enhanced terahertz radiation from a new photoconductive antenna (PCA) has been predicted by numerical simulation. Different from the conventional PCA, the proposed PCA has electrodes with sawtooth structures on the edge, which will introduce stronger localized bias field than common electrode (e.g. strip-line structure). In addition, the elliptical beam of the laser source is used to illuminate the sawtooth structure of the PCA, so that the effective region of the terahertz excitation is enlarged and higher laser power can be applied before saturation effect occurs. The design of the proposed PCA is presented, and its performance is predicated by numerical analysis based on the full-wave finite-difference-time-domain method. The simulated result shows that, comparing with a conventional PCA, the proposed PCA achieves $1.4$ times enhancement of the THz radiation field(i.e. peak of the time-domain THz pulse) at the same condition. Further enhancement as high as $2$ times can be achieved when considering the...

  15. A laser beam welding facility for sealing of miniature radiation sources

    International Nuclear Information System (INIS)

    Full text: A Nd : YAG laser welding facility was installed in a radioactive laboratory of the Radiopharmaceuticals Division, BARC to obtain high quality welds of the titanium encased radiation sources. Radiation sources based on 125I for the treatment of ocular tumors were developed and titanium capsules as specified by IS0 standards were fabricated. The inner core of the tiny sources were prepared and were sealed in titanium capsules of dimensions O.8mm (φ) x 4.5mm (1) by laser welding. The laser beam parameters such as energy, frequency, pulse duration and welding speed were optimized to obtain leak proof welds. Laser welds were also characterized by optical and scanning electron microscopy for assessing its quality. The welded sources showed a total release 125I, which is well below the permissible levels. In this paper we describe the laser welding set up and results of initial development work. We also share our experience to obtain radioactive leak proof laser welding of the 125I sources in titanium capsules

  16. Beam test of a one-dimensional position sensitive chamber on synchrotron radiation

    CERN Document Server

    Mei, Liu; Hui-Rong, Qi; Bao-An, Zhuang; Jian, Zhang; Rong-Guang, Liu; Qi-Ming, Zhu; Qun, Ouyang; Yuan-Bo, Chen; Xiao-Shan, Jiang; Ya-Jie, Wang; Peng, Liu; Guang-Cai, Chang

    2013-01-01

    One-dimensional single-wire chamber was developed to provide high position resolution for powder diffraction experiments with synchrotron radiation. A diffraction test using the sample of SiO2 has been accomplished at 1W2B laboratory of Beijing Synchrotron Radiation Source. The data of beam test were analyzed and some diffraction angles were obtained. The experimental results were in good agreement with standard data from ICDD powder diffraction file. The precision of diffraction angles was 1% to 4.7%. Most of relative errors between measured values of diffraction angles and existing data were less than 1%. As for the detector, the best position resolution in the test was 138 um (sigma value) with an X-ray tube. Finally, discussions of the results were given. The major factor that affected the precision of measurement was deviation from the flat structure of detector. The effect was analyzed and it came to a conclusion that it would be the optimal measurement scheme when the distance between the powder sample...

  17. Radiation dose evaluation of dental cone beam computed tomography using an anthropomorphic adult head phantom

    Science.gov (United States)

    Wu, Jay; Shih, Cheng-Ting; Ho, Chang-hung; Liu, Yan-Lin; Chang, Yuan-Jen; Min Chao, Max; Hsu, Jui-Ting

    2014-11-01

    Dental cone beam computed tomography (CBCT) provides high-resolution tomographic images and has been gradually used in clinical practice. Thus, it is important to examine the amount of radiation dose resulting from dental CBCT examinations. In this study, we developed an in-house anthropomorphic adult head phantom to evaluate the level of effective dose. The anthropomorphic phantom was made of acrylic and filled with plaster to replace the bony tissue. The contour of the head was extracted from a set of adult computed tomography (CT) images. Different combinations of the scanning parameters of CBCT were applied. Thermoluminescent dosimeters (TLDs) were used to measure the absorbed doses at 19 locations in the head and neck regions. The effective doses measured using the proposed phantom at 65, 75, and 85 kVp in the D-mode were 72.23, 100.31, and 134.29 μSv, respectively. In the I-mode, the effective doses were 108.24, 190.99, and 246.48 μSv, respectively. The maximum percent error between the doses measured by the proposed phantom and the Rando phantom was l4.90%. Therefore, the proposed anthropomorphic adult head phantom is applicable for assessing the radiation dose resulting from clinical dental CBCT.

  18. Hounsfield unit recovery in clinical cone beam CT images of the thorax acquired for image guided radiation therapy

    DEFF Research Database (Denmark)

    Thing, Rune Slot; Bernchou, Uffe; Mainegra-Hing, Ernesto;

    2016-01-01

    A comprehensive artefact correction method for clinical cone beam CT (CBCT) images acquired for image guided radiation therapy (IGRT) on a commercial system is presented. The method is demonstrated to reduce artefacts and recover CT-like Hounsfield units (HU) in reconstructed CBCT images of five...

  19. The profile of the electron beam in the PTB synchrotron, and its influence on radiometric measurements with synchrotron radiation

    International Nuclear Information System (INIS)

    A simple method is described to determine the beam profile in an electron synchrotron; the measured results are compared with calculated values. Moreover, the influence of synchrotron- and betatron-oscillations on synchrotron radiation measurements is discussed, and a method is given to correct this. (orig.)

  20. [Specific effect of attenuated strain of Francisella tularensis on the development of radiation induced lesions in experimental animals and effictiveness of antibacterial therapy for lesions induced by radiation combined with virulemt strain of the bacteria].

    Science.gov (United States)

    Nesterenko, V S; Meshcheriakova, I S; Savina, N P; Iatsenko, E M; Kormilitsina, M I; Moiseeva, L A; Khakaiu, I L

    2008-01-01

    For study of the effects of whole-body gamma-radiation (1 and 4 Gy) on the response of the body to administration of vaccines and virulent strains of tularemia 206 outbred white mice were used. The results of the study shown that the administration of attenuated bacterial cells in 5 days after exposure to radiation (1 and 4 Gy) caused more severe post-radiation effects and the increase in the number of died animals. The severity of the disease was less if mice were vaccinated in 26 days after irradiation (4 Gy). The treatment of tularemia in irradiated mice twith Riphampicin (daily peroral administration, 5 mg/mouse, duration of treatment--7 days) administered in 4 hours after infection was effective and caused high survival of affected mice. The results show effectiveness of the riphampicin treatment of tularemia in the animals exposed to sublethal dose of radiation.

  1. A beaming model of the Io-independent Jovian decameter radiation based on multipole models of the Jovian magnetic field

    International Nuclear Information System (INIS)

    A geometrical model is presented in which the apparent source locations of the Io-independent decameter radiation are computed. The calculations assume that the radiation is produced by stably trapped electrons radiating near the electron gyrofrequency and that the emission is then beamed onto a conical surface. The maximum occurrence probability of noise storms is associated with regions in the Jovian magnetosphere where the axis of the emission cone is most inclined toward the Jovian equatorial plane. The calculations utilize and compare two of the octupole spherical harmonic expansions of the Jovian magnetic field constructed from data accumulated by the fluxgate and vector helium magnetometers on board Pioneer 11

  2. Beaming model of the Io-independent jovian decameter radiation based on multipole models of the jovian magnetic field

    International Nuclear Information System (INIS)

    A geometrical model is presented in which the apparent source locations of the Io-independent decameter radiation are computed. The calculations assume that the radiation is produced by stably trapped electrons radiating near the local electron gyrofrequency and that the emission is then beamed onto a conical surface. The maximum occurrence probability of noise storms is a associated with regions in the Jovian magnetosphere where the axis of the emission cone is most inclined toward the Jovian equatorial plane. The calculations utilize and compare two of the octopole spherical harmonic expansions of the Jovian magnetic field constructed from data accumulated by the fluxgate and vector helium magnetometers on board Pioneer 11

  3. Measurement of longitudinal electron beam parameters using indigenously developed streak camera system at Indus-1 synchrotron radiation source

    International Nuclear Information System (INIS)

    Indus-1 is a 450 MeV synchrotron radiation source (SRS) operational at RRCAT, Indore. A diagnostic beamline utilizing visible portion of wide synchrotron radiation spectrum is used for the measurement of electron beam parameters. Its RF frequency and harmonic number are 31.6 MHz and 2 respectively. Among the five operational user beamlines at Indus-1 SRS visible diagnostic beamline (V-DBL, BL-5) is used for the measurement and study of electron beam parameters at dipole magnet DP-3 in Indus-1 .The bunch length represents the extent of longitudinal distribution of electrons inside the bunch, and bunch centroid position is the temporal position or phase of bunch with respect to accelerating voltage inside RF cavity which are important beam dynamics parameters in an accelerator. For measuring the longitudinal beam profile, bunch length, bunch centroid position (of the order of few tens of picoseconds) etc. of the electron beam, a very high temporal resolution device such as streak camera is required to capture the images of the beam in the time domain. For this purpose, an indigenously developed single shot S-20 streak camera has been developed to capture longitudinal profile of electrons bunches in Indus-1 and installed at V-DBL (BL-5). In this paper various measurements carried out using this indigenously developed streak camera system at Indus-1 SRS are discussed

  4. Radioprotective Properties of Allium sativum (Garlic Extract on Cultured Human Lymphocytes against Electron Beam Radiation

    Directory of Open Access Journals (Sweden)

    Shama N Rao

    2015-03-01

    Full Text Available The radioprotective effects of naturally occurring compounds from herbs have been investigated in vitro and in vivo considering their ethnopharmacological role in prevention and treatment of cancer. Allium sativum supplementation in diet has been shown to be beneficial to cancer patients. The present study was designed to detect the radioprotective effect of garlic extract (GE on cultured human peripheral blood lymphocytes. Garlic bulbs were extracted using ethanol and water separately followed by assays on antioxidant activities to assess the efficiency of radical scavenging capacity of various extracts. Lymphocytes were treated with different concentrations of GE for 2, 4, 6 and 24 hr periods. Cell survival was determined by tryphan blue dye exclusion assay, single strand DNA damage by alkaline comet assay and in vitro cytogenetic damages were evaluated by micronucleus assays. Ethanol boiled GE showed highest radical scavenging capacity and reducing property. Treatment of GE to lymphocytes before and after exposure to 4Gy of electron beam radiation (EBR the percentage of tail DNA was reduced from 24.06±3.92 to 2.87±0.18. The elevated micronucleus formation in radiation control group (13.15±0.75 was significantly reduced in various concentrations of GE treated groups (10.35±0.44, 7.05±1.17, 6.42±0.47 respectively. Cells treated with GE at 10µg/mL showed maximum viability after exposure to EBR. Present investigations indicate that ethanol boiled GE shows good radiation protection at 10µg/mL concentration. However, increase in concentration above this dose though resulted in higher protection, increased cell toxicity was also noticed.

  5. Radiation-hard Beam Position Detector for Use in the Accelerator Dump Lines

    CERN Document Server

    Degtiarenko, Pavel; Popov, Vladimir

    2005-01-01

    Proper transport of the electron beam with over 0.5MW of power to the beam dump is a prerequisite for operations at Jefferson Lab. Operations has relied on imaging the beam on a beam viewer located at the entrance to the beam dump. The large beam size at the dump entrance, due to beam scattering in the experimental target, sometimes results in no observable image on the view-screen. Chemical vapor deposited silicon carbide (CVD) material with its large thermal conductivity and high melting point is well suited for surviving the thermal effects of beam exposure with this power density. We are exploring the CVD properties and how it can be used as a robust beam position monitor. Results of some beam tests with 0.5MW beams will be presented.

  6. UO and Zr gamma radiation attenuation coefficients measurements for correction of burn up determination on material self absorption

    International Nuclear Information System (INIS)

    The mass attenuation coefficients of UO2 and Zr have been determined in the energy range 0.5 to 0.8 MeV and used to improve a gamma scanning method developed to determine fuel discontinuities and burnup. The measured values of the UO2 attenuation coefficients were similar to those for Pb and the value of μsub(Zr) was very close to μsub(Mo). In addition measurements are reported which were made on the efficiency in the range 0.5. to 1.2 MeV of the Ge(Li) detector used in the system. (U.K.)

  7. Landing gear noise attenuation

    Science.gov (United States)

    Moe, Jeffrey W. (Inventor); Whitmire, Julia (Inventor); Kwan, Hwa-Wan (Inventor); Abeysinghe, Amal (Inventor)

    2011-01-01

    A landing gear noise attenuator mitigates noise generated by airframe deployable landing gear. The noise attenuator can have a first position when the landing gear is in its deployed or down position, and a second position when the landing gear is in its up or stowed position. The noise attenuator may be an inflatable fairing that does not compromise limited space constraints associated with landing gear retraction and stowage. A truck fairing mounted under a truck beam can have a compliant edge to allow for non-destructive impingement of a deflected fire during certain conditions.

  8. Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Zwicker, F.; Roeder, F.; Debus, J.; Huber, P.E. [University Hospital Center Heidelberg, Heidelberg (Germany). Dept. of Radiation Oncology; Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany). Clinical Cooperation Unit Molecular Radiation Oncology; Kirsner, A.; Weber, K.J. [University Hospital Center Heidelberg, Heidelberg (Germany). Dept. of Radiation Oncology; Peschke, P. [Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany). Clinical Cooperation Unit Molecular Radiation Oncology

    2013-08-15

    Background: Inhibition of pyruvate dehydrogenase kinase (PDK) by dichloroacetate (DCA) can shift tumor cell metabolism from anaerobic glycolysis to glucose oxidation, with activation of mitochondrial activity and chemotherapy-dependent apoptosis. In radiotherapy, DCA could thus potentially enhance the frequently moderate apoptotic response of cancer cells that results from their mitochondrial dysfunction. The aim of this study was to investigate tumor-specific radiosensitization by DCA in vitro and in a human tumor xenograft mouse model in vivo. Materials and methods: The interaction of DCA with photon beam radiation was investigated in the human tumor cell lines WIDR (colorectal) and LN18 (glioma), as well as in the human normal tissue cell lines HUVEC (endothelial), MRC5 (lung fibroblasts) and TK6 (lymphoblastoid). Apoptosis induction in vitro was assessed by DAPI staining and sub-G1 flow cytometry; cell survival was quantified by clonogenic assay. The effect of DCA in vivo was investigated in WIDR xenograft tumors growing subcutaneously on BALB/c-nu/nu mice, with and without fractionated irradiation. Histological examination included TUNEL and Ki67 staining for apoptosis and proliferation, respectively, as well as pinomidazole labeling for hypoxia. Results: DCA treatment led to decreased clonogenic survival and increased specific apoptosis rates in tumor cell lines (LN18, WIDR) but not in normal tissue cells (HUVEC, MRC5, TK6). However, this significant tumor-specific radiosensitization by DCA in vitro was not reflected by the situation in vivo: The growth suppression of WIDR xenograft tumors after irradiation was reduced upon additional DCA treatment (reflected by Ki67 expression levels), although early tumor cell apoptosis rates were significantly increased by DCA. This apparently paradoxical effect was accompanied by a marked DCA-dependent induction of hypoxia in tumor-tissue. Conclusion: DCA induced tumor-specific radiosensitization in vitro but not in vivo

  9. Axial and transverse acoustic radiation forces on a fluid sphere placed arbitrarily in Bessel beam standing wave tweezers

    Energy Technology Data Exchange (ETDEWEB)

    Mitri, F.G., E-mail: mitri@chevron.com

    2014-03-15

    The axial and transverse radiation forces on a fluid sphere placed arbitrarily in the acoustical field of Bessel beams of standing waves are evaluated. The three-dimensional components of the time-averaged force are expressed in terms of the beam-shape coefficients of the incident field and the scattering coefficients of the fluid sphere using a partial-wave expansion (PWE) method. Examples are chosen for which the standing wave field is composed of either a zero-order (non-vortex) Bessel beam, or a first-order Bessel vortex beam. It is shown here, that both transverse and axial forces can push or pull the fluid sphere to an equilibrium position depending on the chosen size parameter ka (where k is the wave-number and a the sphere’s radius). The corresponding results are of particular importance in biophysical applications for the design of lab-on-chip devices operating with Bessel beams standing wave tweezers. Moreover, potential investigations in acoustic levitation and related applications in particle rotation in a vortex beam may benefit from the results of this study. -- Highlights: •The axial and transverse forces on a fluid sphere in acoustical Bessel beams tweezers are evaluated. •The attraction or repulsion to an equilibrium position in the standing wave field is examined. •Potential applications are in particle manipulation using standing waves.

  10. Attenuation-based automatic kilovolt (kV)-selection in computed tomography of the chest: Effects on radiation exposure and image quality

    Energy Technology Data Exchange (ETDEWEB)

    Eller, Achim; Wuest, Wolfgang; Scharf, Michael; Brand, Michael [Department of Radiology, University Erlangen (Germany); Achenbach, Stephan [Department of Cardiology, University Erlangen (Germany); Uder, Michael [Department of Radiology, University Erlangen (Germany); Imaging Science Institute, Erlangen (Germany); Lell, Michael M., E-mail: Michael.lell@uk-erlangen.de [Department of Radiology, University Erlangen (Germany); Imaging Science Institute, Erlangen (Germany)

    2013-12-01

    Objectives: To evaluate an automated attenuation-based kV-selection in computed tomography of the chest in respect to radiation dose and image quality, compared to a standard 120 kV protocol. Materials and methods: 104 patients were examined using a 128-slice scanner. Fifty examinations (58 ± 15 years, study group) were performed using the automated adaption of tube potential (100–140 kV), based on the attenuation profile of the scout scan, 54 examinations (62 ± 14 years, control group) with fixed 120 kV. Estimated CT dose index (CTDI) of the software-proposed setting was compared with a 120 kV protocol. After the scan CTDI volume (CTDIvol) and dose length product (DLP) were recorded. Image quality was assessed by region of interest (ROI) measurements, subjective image quality by two observers with a 4-point scale (3 – excellent, 0 – not diagnostic). Results: The algorithm selected 100 kV in 78% and 120 kV in 22%. Overall CTDIvol reduction was 26.6% (34% in 100 kV) overall DLP reduction was 22.8% (32.1% in 100 kV) (all p < 0.001). Subjective image quality was excellent in both groups. Conclusion: The attenuation based kV-selection algorithm enables relevant dose reduction (∼27%) in chest-CT while keeping image quality parameters at high levels.

  11. Contribution to the beam plasma material interactions during material processing with TEA CO2 laser radiation

    Science.gov (United States)

    Jaschek, Rainer; Konrad, Peter E.; Mayerhofer, Roland; Bergmann, Hans W.; Bickel, Peter G.; Kowalewicz, Roland; Kuttenberger, Alfred; Christiansen, Jens

    1995-03-01

    The TEA-CO2-laser (transversely excited atmospheric pressure) is a tool for the pulsed processing of materials with peak power densities up to 1010 W/cm2 and a FWHM of 70 ns. The interaction between the laser beam, the surface of the work piece and the surrounding atmosphere as well as gas pressure and the formation of an induced plasma influences the response of the target. It was found that depending on the power density and the atmosphere the response can take two forms. (1) No target modification due to optical break through of the atmosphere and therefore shielding of the target (air pressure above 10 mbar, depending on the material). (2) Processing of materials (air pressure below 10 mbar, depending on the material) with melting of metallic surfaces (power density above 0.5 109 W/cm2), hole formation (power density of 5 109 W/cm2) and shock hardening (power density of 3.5 1010 W/cm2). All those phenomena are usually linked with the occurrence of laser supported combustion waves and laser supported detonation waves, respectively for which the mechanism is still not completely understood. The present paper shows how short time photography and spatial and temporal resolved spectroscopy can be used to better understand the various processes that occur during laser beam interaction. The spectra of titanium and aluminum are observed and correlated with the modification of the target. If the power density is high enough and the gas pressure above a material and gas composition specific threshold, the plasma radiation shows only spectral lines of the background atmosphere. If the gas pressure is below this threshold, a modification of the target surface (melting, evaporation and solid state transformation) with TEA-CO2- laser pulses is possible and the material specific spectra is observed. In some cases spatial and temporal resolved spectroscopy of a plasma allows the calculation of electron temperatures by comparison of two spectral lines.

  12. Gamma, electron beam and ultraviolet radiation on control of storage rots and quality of Walla Walla onions

    International Nuclear Information System (INIS)

    Walla Walla onions were irradiated with doses of 0.1, 0.3, 1.0, 2.0 and 3.0 kGy of gamma rays; 0.1, 1.0, 2.0, 3.0 and 5.0 kGy of electron beams; or 0.44 × 104 1.32 × 104, 3.52 × 104, 7.33 × 104 and 19.1 × 104 erg/mm± of UV. The onions were stored up to four weeks at 20–25 C. UV irradiated onions exhibited the greatest percentage of marketable onions and reduction in postharvest rots. Sprouting was obsened with control, UV and electron beam irradiated onions but not with gamma irradiated onions. Effect of gamma, electron beams and UV on pH, moisture, ascorbic acid and color were not significant. Onions became soft with the high dose of gamma radiation (3.0 kGy). Total sugar content was not affected by UV and electron beam but tended to be greatest at the 1.0 kGy gamma radiation. The effect of the radiation on the onion sensory scores was not clearly indicated except that 3.0 kGy gamma ray irradiated onions had the lowest firmness score

  13. Intensity Modulated Proton Beam Radiation for Brachytherapy in Patients With Cervical Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Clivio, Alessandro [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Kluge, Anne [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany); Cozzi, Luca, E-mail: lucozzi@iosi.ch [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Köhler, Christhardt [Department of Gynecology, Charité University Hospital, Berlin (Germany); Neumann, Oliver [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany); Vanetti, Eugenio [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Wlodarczyk, Waldemar; Marnitz, Simone [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany)

    2013-12-01

    Purpose: To evaluate intensity modulated proton therapy (IMPT) in patients with cervical cancer in terms of coverage, conformity, and dose–volume histogram (DVH) parameters correlated with recommendations from magnetic resonance imaging (MRI)-guided brachytherapy. Methods and Materials: Eleven patients with histologically proven cervical cancer underwent primary chemoradiation for the pelvic lymph nodes, the uterus, the cervix, and the parametric region, with a symmetric margin of 1 cm. The prescription was for 50.4 Gy, with 1.8 Gy per fraction. The prescribed dose to the parametria was 2.12 Gy up to 59.36 Gy in 28 fractions as a simultaneous boost. For several reasons, the patients were unable to undergo brachytherapy. As an alternative, IMPT was planned with 5 fractions of 6 Gy to the cervix, including the macroscopic tumor with an MRI-guided target definition, with an isotropic margin of 5 mm for planning target volume (PTV) definition. Groupe-Europeen de Curietherapie and European society for Radiotherapy and Oncology (GEC-ESTRO) criteria were used for DVH evaluation. Reference comparison plans were optimized for volumetric modulated rapid arc (VMAT) therapy with the RapidArc (RA). Results: The dose to the high-risk volume was calculated with α/β = 10 with 89.6 Gy. For IMPT, the clinical target volume showed a mean dose of 38.2 ± 5.0 Gy (35.0 ±1.8 Gy for RA). The D{sub 98%} was 31.9 ± 2.6 Gy (RA: 30.8 ± 1.0 Gy). With regard to the organs at risk, the 2Gy Equivalent Dose (EQD2) (α/β = 3) to 2 cm{sup 3} of the rectal wall, sigmoid wall, and bladder wall was 62.2 ± 6.4 Gy, 57.8 ± 6.1 Gy, and 80.6 ± 8.7 Gy (for RA: 75.3 ± 6.1 Gy, 66.9 ± 6.9 Gy, and 89.0 ± 7.2 Gy, respectively). For the IMPT boost plans in combination with external beam radiation therapy, all DVH parameters correlated with <5% risk for grades 2 to 4 late gastrointestinal and genitourinary toxicity. Conclusion: In patients who are not eligible for brachytherapy, IMPT as a boost

  14. Beam-excited whistler waves at oblique propagation with relation to STEREO radiation belt observations

    Directory of Open Access Journals (Sweden)

    K. Sauer

    2010-06-01

    Full Text Available Isotropic electron beams are considered to explain the excitation of whistler waves which have been observed by the STEREO satellite in the Earth's radiation belt. Aside from their large amplitudes (~240 mV/m, another main signature is the strongly inclined propagation direction relative to the ambient magnetic field. Electron temperature anisotropy with Te⊥>Te||, which preferentially generates parallel propagating whistler waves, can be excluded as a free energy source. The instability arises due to the interaction of the Doppler-shifted cyclotron mode ω=−Ωe+kVbcosθ with the whistler mode in the wave number range of kce≤1 (θ is the propagation angle with respect to the background magnetic field direction, ωe is the electron plasma frequency and Ωe the electron cyclotron frequency. Fluid and kinetic dispersion analysis have been used to calculate the growth rate of the beam-excited whistlers including the most important parameter dependencies. One is the beam velocity (Vb which, for instability, has to be larger than about 2VAe, where VAe is the electron Alfvén speed. With increasing VAe the propagation angle (θ of the fastest growing whistler waves shifts from θ~20° for Vb=2VAe to θ~80° for Vb=5VAe. The growth rate is reduced by finite electron temperatures and disappears if the electron plasma beta (βe exceeds βe~0.2. In addition, Gendrin modes (kce≈1 are analyzed to determine the conditions under which stationary nonlinear waves (whistler oscillitons can exist. The corresponding spatial wave profiles are calculated using the full nonlinear fluid approach. The results are compared with the STEREO satellite observations.

  15. Points to be noted in using radiation treatment planning system; External photon beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Irifune, Toraji (Tokyo Metropolitan Coll. of Allied Medical Sciences (Japan))

    1993-09-01

    The accuracy of absorbed dose calculations for external photon beam therapy depends on the computational algorithms being used: the acquisition of basic beam data, the patient's anatomical information, the spacing of the points in the matrices, the interpolation routine, inhomogeneity corrections, etc. At present, the dose calculation algorithms employed in most commercially available treatment planning systems for absorbed dose calculation are two-dimensional methods for photon fluence and do not take electronic equilibrium into account. Therefore, their use for radiation treatment planning is limited. In particular, the problem of inhomogeneity correction for lung is the most significant. The inhomogeneity correction methods most commonly used are ratio of TAR (RTAR), power law TAR (PTAR) and equivalent TAR (ETAR) methods. One Japanese society for therapeutic radiology and oncology (JASTRO) task group has compared the three correction methods mentioned above with measured values using the same JARP level dosimeter and lung model phantom. The photon energies were [sup 60]Co [gamma] rays, 4, 6, 10 and 18 MV x rays, and field sizes were 5 x 5, 10 x 10 and 20 x 20 cm[sup 2] at SSD 100 cm. RTAR lead to errors (%) of 2.5 to 12.6, 1.7 to 10.9, 2.7 to 8.5, 3.1 to 9.9, and 1.0 to 19.1; PTAR errors were -0.7 to 2.3, -2.1 to 1.6, -1.1 to 2.2, -0.3 to 3.9, and -2.0 to 6.6; and ETAR errors were 0.7 to 2.5, 0 to 3.1, -0.1 to 6.8, 3.4 to 9.2, and 1.0 to 18.6 for [sup 60]Co [gamma] rays, 4, 6, 10 and 18 MV x rays, respectively. Survey results showed that about 50% of the institutions used measured data obtained by themselves. Basic beam data acquisition should be self-contained. (author).

  16. Study of the measurement of critical parameters in an electron beam radiation facility. Application to the case of the first accelerator dedicated to radiation in Tunisia

    Energy Technology Data Exchange (ETDEWEB)

    M' Garrech, S. [Laboratoire de Radio-traitement, Centre National des Sciences et Technologies Nucleaires, 2020 Sidi-Thabet (Tunisia)], E-mail: mgslah@yahoo.fr; Ezzouch, A. [Institut National des Sciences Appliquees et de Technologie, 1080 Tunis (Tunisia)

    2009-02-15

    The Tunisian National Center for Nuclear Sciences and Technologies will acquire the first North African Radio Frequency linear accelerator of electrons in 2009. The facility will be designed primarily for sterilization of medical devices and preservation of foodstuff. The first part of this paper is dedicated to a description of the facility. In order to adjust the treatment conditions and to control the good operation of the accelerator, it is necessary to find out several electron beam parameters. The second part of the paper is devoted to the presentation of the system dedicated to determining several key parameters of the electron beam. The performances and advantages of the diagnostic system cited in this report make it quite suitable for process control application at an electron beam radiation processing facility.

  17. Study of the measurement of critical parameters in an electron beam radiation facility. Application to the case of the first accelerator dedicated to radiation in Tunisia

    International Nuclear Information System (INIS)

    The Tunisian National Center for Nuclear Sciences and Technologies will acquire the first North African Radio Frequency linear accelerator of electrons in 2009. The facility will be designed primarily for sterilization of medical devices and preservation of foodstuff. The first part of this paper is dedicated to a description of the facility. In order to adjust the treatment conditions and to control the good operation of the accelerator, it is necessary to find out several electron beam parameters. The second part of the paper is devoted to the presentation of the system dedicated to determining several key parameters of the electron beam. The performances and advantages of the diagnostic system cited in this report make it quite suitable for process control application at an electron beam radiation processing facility.

  18. Analysis and comparison of immune reactivity in guinea-pigs immunized with equivalent numbers of normal or radiation-attenuated cercariae of Schistosoma mansoni

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, M.V.; McLaren, D.J.

    1987-08-01

    Guinea-pigs immunized with equivalent numbers of normal or radiation-attenuated cercariae of Schistosoma mansoni develop close to complete resistance to reinfection at weeks 12 and 4.5 respectively. We here analyse and compare the immune responses induced by the two populations of cercariae. Both radiation-attenuated and normal parasites of S. mansoni elicited an extensive germinal centre response in guinea-pigs by week 4.5 post-immunization. The anti-parasite antibody titre and cytotoxic activity of serum from 4.5-week-vaccinated, or 4.5-week-infected guinea-pigs were approximately equal, but sera from 12-week-infected individuals had high titres of anti-parasite antibody, which promoted significant larvicidal activity in vitro. In all cases, larvicidal activity was mediated by the IgG/sub 2/ fraction of the immune serum. Lymphocyte transformation tests conducted on splenic lymphocytes from 4.5-week vaccinated guinea-pigs revealed maximal stimulation against cercarial, 2-week and 3-week worm antigens, whereas spleen cells from 4.5-week-infected guinea-pigs were maximally stimulated by cercarial and 6-week worm antigens. The splenic lymphocyte responses of 12-week infected animals were dramatic against antigens prepared from all life-stages of the parasite.

  19. Measuring radiation damage dynamics by pulsed ion beam irradiation. 2015 Annual Progress Report for DOE/NE/NEET

    Energy Technology Data Exchange (ETDEWEB)

    Kucheyev, S. O. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-03-07

    The major goal of this project is to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation processes in nuclear materials. In particular, the project exploits a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. For Year 2, this project had the following two major milestones: (i) measurement of the temperature dependence of defect dynamics in SiC and (ii) the evaluation of the robustness of the pulsed beam method from studies of the defect generation rate. As we describe below, both of these milestones have been met.

  20. Measuring radiation damage dynamics by pulsed ion beam irradiation. 2015 Annual Progress Report for DOE/NE/NEET

    International Nuclear Information System (INIS)

    The major goal of this project is to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation processes in nuclear materials. In particular, the project exploits a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. For Year 2, this project had the following two major milestones: (i) measurement of the temperature dependence of defect dynamics in SiC and (ii) the evaluation of the robustness of the pulsed beam method from studies of the defect generation rate. As we describe below, both of these milestones have been met.

  1. Evaluation of radiotherapy beams attenuation and scattering caused by a printed phantom filled with an organic solution used in nanoparticle synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Eduardo L.; Bosch-Santos, Brianna; Veneziani, Glauco R.; Vivolo, Vitor; Carbonari, Artur W.; Potiens, Maria da Penha A., E-mail: educorrea1905@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    In the past years nanotechnology has been distinguishing as a quick growing field, with many medical applications including drug delivery and medical images. For medical procedures gold nanoparticles (AuNPs) have been widely studied. The characteristics that make this material a good option to improve radiosensitivity in a specific tissue are their stability in a biological ambient and affinity to polyethylene glycol, which reduces its toxicity in mammals. A good method to produce AuNPs for medical applications is thermal decomposition, which is known for providing homogenous nanostructures and narrow size distribution. This production process consists in mixing gold acetate in an organic solution containing diphenyl ether, oleylamine, oleic acid and 1,2 octanediol, which is kept in a temperature of 300 deg C for about two hours. After cooled the mixture must be centrifuged and washed in order to obtain the nanostructured grains. In this study a behavior comparison between water and the organic solution was made. The goal is to verify the viability of using this solution, instead of water, with a 3D printed phantom, as a dosimetric reference, since the removal process of nanoparticles from this solution to take them to water may cause a huge material loss. The comparison procedure was made in an industrial X-ray system operating in a voltage range from 10 kV to 50 kV. The results presented a variation up to 42.2 % between water and the organic solution radiation attenuation and up to 30 % for radiation scattering. (author)

  2. Evaluation of radiotherapy beams attenuation and scattering caused by a printed phantom filled with an organic solution used in nanoparticle synthesis

    International Nuclear Information System (INIS)

    In the past years nanotechnology has been distinguishing as a quick growing field, with many medical applications including drug delivery and medical images. For medical procedures gold nanoparticles (AuNPs) have been widely studied. The characteristics that make this material a good option to improve radiosensitivity in a specific tissue are their stability in a biological ambient and affinity to polyethylene glycol, which reduces its toxicity in mammals. A good method to produce AuNPs for medical applications is thermal decomposition, which is known for providing homogenous nanostructures and narrow size distribution. This production process consists in mixing gold acetate in an organic solution containing diphenyl ether, oleylamine, oleic acid and 1,2 octanediol, which is kept in a temperature of 300 deg C for about two hours. After cooled the mixture must be centrifuged and washed in order to obtain the nanostructured grains. In this study a behavior comparison between water and the organic solution was made. The goal is to verify the viability of using this solution, instead of water, with a 3D printed phantom, as a dosimetric reference, since the removal process of nanoparticles from this solution to take them to water may cause a huge material loss. The comparison procedure was made in an industrial X-ray system operating in a voltage range from 10 kV to 50 kV. The results presented a variation up to 42.2 % between water and the organic solution radiation attenuation and up to 30 % for radiation scattering. (author)

  3. Self-consistent simulation of radiation and space-charge in high-brightness relativistic electron beams

    Science.gov (United States)

    Gillingham, David R.

    2007-12-01

    The ability to preserve the quality of relativistic electron beams through transport bend elements such as a bunch compressor chicane is increasingly difficult as the current increases because of effects such as coherent synchrotron radiation (CSR) and space-charge. Theoretical CSR models and simulations, in their current state, often make unrealistic assumptions about the beam dynamics and/or structures. Therefore, we have developed a model and simulation that contains as many of these elements as possible for the purpose of making high-fidelity end-to-end simulations. Specifically, we are able to model, in a completely self-consistent, three-dimensional manner, the sustained interaction of radiation and space-charge from a relativistic electron beam in a toroidal waveguide with rectangular cross-section. We have accomplished this by combining a time-domain field solver that integrates a paraxial wave equation valid in a waveguide when the dimensions are small compared to the bending radius with a particle-in-cell dynamics code. The result is shown to agree with theory under a set of constraints, namely thin rigid beams, showing the stimulation resonant modes and including comparisons for waveguides approximating vacuum, and parallel plate shielding. Using a rigid beam, we also develop a scaling for the effect of beam width, comparing both our simulation and numerical integration of the retarded potentials. We further demonstrate the simulation calculates the correct longitudinal space-charge forces to produce the appropriate potential depression for a converging beam in a straight waveguide with constant dimensions. We then run fully three-dimensional, self-consistent end-to-end simulations of two types of bunch compressor designs, illustrating some of the basic scaling properties and perform a detailed analysis of the output phase-space distribution. Lastly, we show the unique ability of our simulation to model the evolution of charge/energy perturbations on a

  4. The geometric calibration of cone-beam imaging and delivery systems in radiation therapy

    CERN Document Server

    Matsinos, E; Kaissl, Wolfgang; Matsinos, Evangelos

    2006-01-01

    We propose a method to achieve the geometric calibration of cone-beam imaging and delivery systems in radiation therapy; our approach applies to devices where an X-ray source and a flat-panel detector, facing each other, move in circular orbits around the irradiated object. In order to extract the parameters of the geometry from the data, we use a light needle phantom which is easy to manufacture. A model with ten free parameters (spatial lengths and distortion angles) has been put forth to describe the geometry and the mechanical imperfections of the units being calibrated; a few additional parameters are introduced to account for residual effects (small effects which lie beyond our model). The values of the model parameters are determined from one complete scan of the needle phantom via a robust optimisation scheme. The application of this method to two sets of five counterclockwise (ccw) and five clockwise (cw) scans yielded consistent and reproducible results. A number of differences have been observed be...

  5. Coupled electron beam radiation and MBR treatment of textile wastewater containing polyvinyl alcohol.

    Science.gov (United States)

    Sun, Weihua; Chen, Jun; Chen, Lujun; Wang, Jianlong; Zhang, Yongming

    2016-07-01

    Advanced oxidation processes (AOP) can be combined with biological treatments for recalcitrant organic pollutant decomposition. However, there has been no thorough investigation on the coupling of AOPs and membrane bioreactors (MBR) to treat polymer organic pollutants. This study proposes a new AOP that couples electron beam (EB) radiation and MBR treatment. This method was applied to treat real textile effluents containing polyvinyl alcohol (PVA). During the stable operation stage, 31 ± 7% (n = 28) COD was removed by the EB-MBR process. COD removal was enhanced to 45% at the end of the research period without process optimization. In addition, both the membrane flux and activated sludge system exhibited good stability. Only a 2% membrane flux decreased was observed after a 46 d operation period. PVA radiolysis and biofacies analysis mechanisms are also discussed. By contrast, PVA degradation using only the MBR treatment was ineffective in this study. This ineffectiveness was caused by membrane interception and floccule formation by PVA and activated sludge. PMID:27107385

  6. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    CERN Document Server

    Watt, J; Campbell, M; Mathieson, K; Mikulec, B; O'Shea, V; Passmore, M S; Schwarz, C; Smith, K M; Whitehill, C

    2001-01-01

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 mu m thick SI-LEC GaAs detector patterned in a 64*64 array of 170 mu m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO/sub 3/ have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the Omega 3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the Omega 3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and...

  7. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    Energy Technology Data Exchange (ETDEWEB)

    Watt, J. E-mail: j.watt@physics.gla.ac.uk; Bates, R.; Campbell, M.; Mathieson, K.; Mikulec, B.; O' Shea, V.; Passmore, M-S.; Schwarz, C.; Smith, K.M.; Whitehill, C

    2001-03-11

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 {mu}m thick SI-LEC GaAs detector patterned in a 64x64 array of 170 {mu}m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO{sub 3} have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the {omega}3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the {omega}3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and image processing are given, showing a marked reduction in patient dose and dead time compared with film.

  8. Wettability modification of human tooth surface by water and UV and electron-beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Tiznado-Orozco, Gaby E., E-mail: gab0409@gmail.com [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Unidad Académica de Odontología, Universidad Autónoma de Nayarit, Edificio E7, Ciudad de la Cultura “Amado Nervo”, C.P. 63190 Tepic, Nayarit (Mexico); Reyes-Gasga, José, E-mail: jreyes@fisica.unam.mx [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Instituto de Física, UNAM, Circuito de la Investigación s/n, Ciudad Universitaria, 04510 Coyoacan, México, D.F. (Mexico); Elefterie, Florina, E-mail: elefterie_florina@yahoo.com [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Beyens, Christophe, E-mail: christophe.beyens@ed.univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Maschke, Ulrich, E-mail: Ulrich.Maschke@univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Brès, Etienne F., E-mail: etienne.bres@univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France)

    2015-12-01

    The wettability of the human tooth enamel and dentin was analyzed by measuring the contact angles of a drop of distilled water deposited on the surface. The samples were cut along the transverse and longitudinal directions, and their surfaces were subjected to metallographic mirror-finish polishing. Some samples were also acid etched until their microstructure became exposed. Wettability measurements of the samples were done in dry and wet conditions and after ultraviolet (UV) and electron beam (EB) irradiations. The results indicate that water by itself was able to increase the hydrophobicity of these materials. The UV irradiation momentarily reduced the contact angle values, but they recovered after a short time. EB irradiation raised the contact angle and maintained it for a long time. Both enamel and dentin surfaces showed a wide range of contact angles, from approximately 10° (hydrophilic) to 90° (hydrophobic), although the contact angle showed more variability on enamel than on dentin surfaces. Whether the sample's surface had been polished or etched did not influence the contact angle value in wet conditions. - Highlights: • Human tooth surface wettability changes in dry/wet and UV/EB radiation conditions. • More variability in contact angle is observed on enamel than on dentin surfaces. • Water by itself increases the hydrophobicity of the human tooth surface. • UV irradiation reduces momentarily the human tooth surface hydrophobicity. • EB irradiation increases and maintains the hydrophobicity for a long time.

  9. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    Science.gov (United States)

    Watt, J.; Bates, R.; Campbell, M.; Mathieson, K.; Mikulec, B.; O'Shea, V.; Passmore, M.-S.; Schwarz, C.; Smith, K. M.; Whitehill, C.; XIMAGE Project

    2001-03-01

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 μm thick SI-LEC GaAs detector patterned in a 64×64 array of 170 μm pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO 3 have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the Ω3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the Ω3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and image processing are given, showing a marked reduction in patient dose and dead time compared with film.

  10. Radiation response of multi-quantum well solar cells: Electron-beam-induced current analysis

    Energy Technology Data Exchange (ETDEWEB)

    Maximenko, S. I., E-mail: sergey.maximenko@nrl.navy.mil; Scheiman, D. A.; Jenkins, P. P.; Walters, R. J. [Naval Research Laboratory, Washington, DC 20375 (United States); Lumb, M. P.; Hoheisel, R. [The George Washington University, Washington, DC 20052 (United States); Gonzalez, M. [Sotera Defense Solutions, Herndon, Virginia 20171 (United States); Messenger, S. R. [University of Maryland Baltimore County, Baltimore, Maryland 21250 (United States); Tibbits, T. N. D. [QuantaSol Ltd, Kingston-upon-Thames KT1 3GZ (United Kingdom); Imaizumi, M. [Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki 305-8505 (Japan); Ohshima, T.; Sato, S. I. [Japan Atomic Energy Agency (JAEA), Takasaki, Gunma 370-1292 (Japan)

    2015-12-28

    Solar cells utilizing multi-quantum well (MQW) structures are considered promising candidate materials for space applications. An open question is how well these structures can resist the impact of particle irradiation. The aim of this work is to provide feedback about the radiation response of In{sub 0.01}Ga{sub 0.99}As solar cells grown on Ge with MQWs incorporated within the i-region of the device. In particular, the local electronic transport properties of the MQW i-regions of solar cells subjected to electron and proton irradiation were evaluated experimentally using the electron beam induced current (EBIC) technique. The change in carrier collection distribution across the MQW i-region was analyzed using a 2D EBIC diffusion model in conjunction with numerical modeling of the electrical field distribution. Both experimental and simulated findings show carrier removal and type conversion from n- to p-type in MQW i-region at a displacement damage dose as low as ∼6.06–9.88 × 10{sup 9} MeV/g. This leads to a redistribution of the electric field and significant degradation in charge carrier collection.

  11. Radiation chemistry in alanine irradiated with γ-rays and ion beams

    International Nuclear Information System (INIS)

    In order to extend the application of alanine dosimetry, the behavior of free radicals in solid α-alanine irradiated with γ-rays and with ion beams was studied by electron spin resonance. Stable neutral radicals are produced through the decomposition of originally generated ion radicals in alanine irradiated at 300 K, while at 77 K the ion radicals are stable, and also do not decompose. The rate of the combination reaction of the neutral radicals and of the ion radicals was studied by measuring the saturation behavior of the radical concentration in γ-radiolysis at 300 and at 77 K. The yield of the neutral radicals was compared between 0.5, 1,2 and 3 MeV H+, 0.5, 1, and 3 MeV He+, 175 MeV Ar8+ and 460 MeV Ar13+ ion irradiations. Dependence of the radical yield on the radiation quality is understood more in terms of the rate of the combination reaction between the ion radicals than with that between the neutral radicals, and has to do with high local dose within the ion tracks. (Author)

  12. Radiation chemistry in alanine irradiated with {gamma}-rays and ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Koizumi, Hitoshi; Ichikawa, Tsuneki; Yoshida, Hiroshi [Hokkaido Univ., Sapporo (Japan). Faculty of Engineering

    1997-01-01

    In order to extend the application of alanine dosimetry, the behavior of free radicals in solid {alpha}-alanine irradiated with {gamma}-rays and with ion beams was studied by electron spin resonance. Stable neutral radicals are produced through the decomposition of originally generated ion radicals in alanine irradiated at 300 K, while at 77 K the ion radicals are stable, and also do not decompose. The rate of the combination reaction of the neutral radicals and of the ion radicals was studied by measuring the saturation behavior of the radical concentration in {gamma}-radiolysis at 300 and at 77 K. The yield of the neutral radicals was compared between 0.5, 1,2 and 3 MeV H{sup +}, 0.5, 1, and 3 MeV He{sup +}, 175 MeV Ar{sup 8+} and 460 MeV Ar{sup 13+} ion irradiations. Dependence of the radical yield on the radiation quality is understood more in terms of the rate of the combination reaction between the ion radicals than with that between the neutral radicals, and has to do with high local dose within the ion tracks. (Author).

  13. Long-term results of intraoperative electron beam radiation therapy for nonmetastatic locally advanced pancreatic cancer

    Science.gov (United States)

    Chen, Yingtai; Che, Xu; Zhang, Jianwei; Huang, Huang; Zhao, Dongbing; Tian, Yantao; Li, Yexiong; Feng, Qinfu; Zhang, Zhihui; Jiang, Qinglong; Zhang, Shuisheng; Tang, Xiaolong; Huang, Xianghui; Chu, Yunmian; Zhang, Jianghu; Sun, Yuemin; Zhang, Yawei; Wang, Chengfeng

    2016-01-01

    Abstract To assess prognostic benefits of intraoperative electron beam radiation therapy (IOERT) in patients with nonmetastatic locally advanced pancreatic cancer (LAPC) and evaluate optimal adjuvant treatment after IOERT. A retrospective cohort study using prospectively collected data was conducted at the Cancer Hospital of the Chinese Academy of Medical Sciences, China National Cancer Center. Two hundred forty-seven consecutive patients with nonmetastatic LAPC who underwent IOERT between January 2008 and May 2015 were identified and included in the study. Overall survival (OS) was calculated from the day of IOERT. Prognostic factors were examined using Cox proportional hazards models. The 1-, 2-, and 3-year actuarial survival rates were 40%, 14%, and 7.2%, respectively, with a median OS of 9.0 months. On multivariate analysis, an IOERT applicator diameter strategy incorporating IOERT and postoperative adjuvant treatment. Chemoradiotherapy followed by chemotherapy might be a recommended adjuvant treatment strategy for well-selected cases. Intraoperative interstitial sustained-release 5-fluorouracil chemotherapy should not be recommended for patients with nonmetastatic LAPC. PMID:27661028

  14. Investigation of GEM-Micromegas detector on X-ray beam of synchrotron radiation

    Science.gov (United States)

    Zhang, Yu-Lian; Qi, Hui-Rong; Hu, Bi-Tao; Fan, Sheng-Nan; Wang, Bo; Liu, Mei; Zhang, Jian; Liu, Rong-Guang; Chang, Guang-Cai; Liu, Peng; Ouyang, Qun; Chen, Yuan-Bo; Yi, Fu-Ting

    2014-04-01

    To reduce the discharge of the standard bulk Micromegas and GEM detectors, a GEM-Micromegas detector was developed at the Institute of High Energy Physics. Taking into account the advantages of the two detectors, one GEM foil was set as a preamplifier on the mesh of Micromegas in the structure and the GEM preamplification decreased the working voltage of Micromegas to significantly reduce the effect of the discharge. At the same gain, the spark probability of the GEM-Micromegas detector can be reduced to a factor 0.01 compared to the standard Micromegas detector, and an even higher gain could be obtained. This paper describes the performance of the X-ray beam detector that was studied at 1W2B Laboratory of Beijing Synchrotron Radiation Facility. Finally, the result of the energy resolution under various X-ray energies was given in different working gases. This indicates that the GEM-Micromegas detector has an energy response capability in an energy range from 6 keV to 20 keV and it could work better than the standard bulk-Micromegas.

  15. Deformable image registration of CT and truncated cone-beam CT for adaptive radiation therapy

    Science.gov (United States)

    Zhen, Xin; Yan, Hao; Zhou, Linghong; Jia, Xun; Jiang, Steve B.

    2013-11-01

    Truncation of a cone-beam computed tomography (CBCT) image, mainly caused by the limited field of view (FOV) of CBCT imaging, poses challenges to the problem of deformable image registration (DIR) between computed tomography (CT) and CBCT images in adaptive radiation therapy (ART). The missing information outside the CBCT FOV usually causes incorrect deformations when a conventional DIR algorithm is utilized, which may introduce significant errors in subsequent operations such as dose calculation. In this paper, based on the observation that the missing information in the CBCT image domain does exist in the projection image domain, we propose to solve this problem by developing a hybrid deformation/reconstruction algorithm. As opposed to deforming the CT image to match the truncated CBCT image, the CT image is deformed such that its projections match all the corresponding projection images for the CBCT image. An iterative forward-backward projection algorithm is developed. Six head-and-neck cancer patient cases are used to evaluate our algorithm, five with simulated truncation and one with real truncation. It is found that our method can accurately register the CT image to the truncated CBCT image and is robust against image truncation when the portion of the truncated image is less than 40% of the total image. Part of this work was presented at the 54th AAPM Annual Meeting (Charlotte, NC, USA, 29 July-2 August 2012).

  16. Axial and transverse acoustic radiation forces on a fluid sphere placed arbitrarily in Bessel beam standing wave tweezers

    Science.gov (United States)

    Mitri, F. G.

    2014-03-01

    The axial and transverse radiation forces on a fluid sphere placed arbitrarily in the acoustical field of Bessel beams of standing waves are evaluated. The three-dimensional components of the time-averaged force are expressed in terms of the beam-shape coefficients of the incident field and the scattering coefficients of the fluid sphere using a partial-wave expansion (PWE) method. Examples are chosen for which the standing wave field is composed of either a zero-order (non-vortex) Bessel beam, or a first-order Bessel vortex beam. It is shown here, that both transverse and axial forces can push or pull the fluid sphere to an equilibrium position depending on the chosen size parameter ka (where k is the wave-number and a the sphere's radius). The corresponding results are of particular importance in biophysical applications for the design of lab-on-chip devices operating with Bessel beams standing wave tweezers. Moreover, potential investigations in acoustic levitation and related applications in particle rotation in a vortex beam may benefit from the results of this study.

  17. Diamonds are not forever - scCVD radiation damage study with high intensity Au beam in HADES

    International Nuclear Information System (INIS)

    Since more than 10 years the HADES group has been involved in the development of diamond detectors based on pcCVD material. These detectors showed very good performance (time resolution below 100 ps sigma) and stable long term operation (over several weeks) at moderate beam (12C) intensities about 105 particles/s/cm2. With the recently finished upgrade of the HADES spectrometer, aimed at preparing for experiments at SIS-100 at the future FAIR facility, the DAQ performance was significantly increased allowing for high intensity beams. The upcoming Au+Au experiment, scheduled for 2012, will utilize an Au beam at intensities between 2-5.106 Au ions/s. Due to the requested very small target diameter, 2.2 mm, the HADES beam focus system has to provide a beam spot below 2 mm2 in the HADES focal point. During a recently conducted five day long test experiment at this beam intensity we have reached a total particle dose close to 2.37.1013 Au ions/cm2 on our diamond start detector which was never archived before. By analysing the surface of the detector and properties like signal amplitude and time resolution we have identified significant radiation damage. In this talk the observed effects are discussed.

  18. SU-E-T-571: Newly Emerging Integrated Transmission Detector Systems Provide Online Quality Assurance of External Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: Two newly emerging transmission detectors positioned upstream from the patient have been evaluated for online quality assurance of external beam radiotherapy. The prototype for the Integral Quality Monitor (IQM), developed by iRT Systems GmbH (Koblenz, Germany) is a large-area ion chamber mounted on the linac accessory tray to monitor photon fluence, energy, beam shape, and gantry position during treatment. The ion chamber utilizes a thickness gradient which records variable response dependent on beam position. The prototype of Delta4 Discover™, developed by ScandiDos (Uppsala, Sweden) is a linac accessory tray mounted 4040 diode array that measures photon fluence during patient treatment. Both systems are employable for patient specific QA prior to treatment delivery. Methods: Our institution evaluated the reproducibility of measurements using various beam types, including VMAT treatment plans with both the IQM ion chamber and the Delta4 Discover diode array. Additionally, the IQM’s effect on photon fluence, dose response, simulated beam error detection, and the accuracy of the integrated barometer, thermometer, and inclinometer were characterized. The evaluated photon beam errors are based on the annual tolerances specified in AAPM TG-142. Results: Repeated VMAT treatments were measured with 0.16% reproducibility by the IQM and 0.55% reproducibility by the Delta4 Discover. The IQM attenuated 6, 10, and 15 MV photon beams by 5.43±0.02%, 4.60±0.02%, and 4.21±0.03% respectively. Photon beam profiles were affected <1.5% in the non-penumbra regions. The IQM’s ion chamber’s dose response was linear and the thermometer, barometer, and inclinometer agreed with other calibrated devices. The device detected variations in monitor units delivered (1%), field position (3mm), single MLC leaf positions (13mm), and photon energy. Conclusion: We have characterized two new transmissions detector systems designed to provide in-vivo like measurements upstream

  19. X-ray diffraction using synchrotron radiation on the G.I.L.D.A. beam line at the E.S.R.F

    Energy Technology Data Exchange (ETDEWEB)

    Balerna, A. [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Meneghini, C. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)]|[INFM, Genoa (Italy); Bordoni, S. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica; Mobilio, S. [Rome Univ. III (Italy). Dip. di Fisica `E. Amaldi`

    1996-09-01

    The aim of this lecture is to make a short introduction on Synchrotron radiation, its history and main properties. The main components of a synchrotron radiation beam line will be described. The Italian beam line, General purpose Italian beam line Line for Diffraction and Absorption (G.I.L.D.A.) at the European Synchrotron Radiation Facility (E.S.R.F.) in Grenoble will be used as an example. The G.I.L.D.A. diffractometer will be described in detail reporting also some experimental results.

  20. Performance studies of an optical fiber OSL/RL dosimetry system in pulsed high-intensity radiation beams

    CERN Document Server

    Ravotti, F; Dusseau, Laurent; Mukherjee, Bhaskar; Glaser, Maurice; Ravotti, Federico

    2010-01-01

    The SrS:Ce,Sm phosphor is suitable for operation in harsh radiation environments where real-time dosimetry measurements are needed to survey the Total Ionizing Dose (TID) damage in electronic components. For these applications, the OSL and RL emissions from this phosphor can be exploited by mounting the SrS crystal at the edge of a single, radiation-hard, optical fiber. In this work we present an exhaustive characterization of this real-time OSL/RL probe including stability, repeatability of the measured signals, dosimetry performance and measurements of the temporal behavior of the RI signal in pulsed particle beams. (C) 2009 Elsevier Ltd. All rights reserved.

  1. Neutron attenuation characteristics of polyethylene, polyvinyl chloride, and heavy aggregate concrete and mortars.

    Science.gov (United States)

    Abdul-Majid, S; Othman, F

    1994-03-01

    Polyethylene and polyvinyl chloride pellets were introduced into concrete to improve its neutron attenuation characteristics while several types of heavy coarse aggregates were used to improve its gamma ray attenuation properties. Neutron and gamma ray attenuation were studied in concrete samples containing coarse aggregates of barite, pyrite, basalt, hematite, and marble as well as polyethylene and polyvinyl chloride pellets in narrow-beam geometry. The highest neutron attenuation was shown by polyethylene mortar, followed by polyvinyl chloride mortar; barite and pyrite concrete showed higher gamma ray attenuation than ordinary concrete. Broad-beam and continuous (infinite) medium geometries were used to study the neutron attenuation of samples containing polymers at different concentrations with and without heavy aggregates, the fitting equations were established, and from these the neutron removal coefficients were deduced. In a radiation field of neutrons and gamma rays, the appropriate concentration of polymer and heavy aggregate can be selected to give the optimum total dose attenuation depending on the relative intensities of each type of radiation. This would give much better design flexibility over ordinary concrete. The compressive strength tests performed on mortar and concrete samples showed that their value, in general, decreases as polymer concentration increases and that the polyvinyl chloride mortar showed higher values than the polyethylene mortar. For general construction purposes, the compression strength was considered acceptable in these samples.

  2. Evaluating the influence of 6 MV and 15 MV photon beams on prostate intensity-modulated radiation therapy plans

    Institute of Scientific and Technical Information of China (English)

    Reham A El Gendy; Ehab M Attalla; Yasser M Elkerm; Ali Alfarrash

    2016-01-01

    Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy (IMRT) photon beams on the target volume planning and on the critical organs in the case of prostate can-cer. Methods Thirty plans were generated by using either 6 MV or 15 MV beams separately, and a combination of both 6 and 15 MV beams. Al plans were generated by using suitable planning objectives and dose con-straints, which were identical across the plans, except the beam energy. The plans were analyzed in terms of their target coverage, conformity, and homogeneity, regardless of the beam energy. Results The mean percentage values of V70 Gy for the rectal wal for the plans with 6 MV, 15 MV, and mixed-energy beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were 53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 MV, 15 MV, and mixed-en-ergy plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 MV plans was 10% larger than those for the 15 MV and mixed-energy plans. Conclusion These preliminary results suggest that mixed-energy IMRT plans may be advantageous with respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the organs at risk may not be clinical y relevant, in this study, IMRT plans using mixed-energy beams exhibited better OAR sparing and overal higher plan quality for deep-seated tumors.

  3. Calculation And Design Of A New Configuration For Radiation Shielding At Neutron Beam No.3 For Fundamental And Applied Researches

    International Nuclear Information System (INIS)

    The tangential horizontal channel of No. 3 of the Dalat Research Reactor has been opened and used during the 1990s. The utilizations of the thermal neutron beam at this channel were the Neutron Radiography and the Prompt Gamma Neutron Activation Analysis method (PGNAA). At present, the neutron beam used for nuclear structure data researches based on the Summing of Amplitude Coincident Pulses system (SACP). Beside, several related research equipments have been set up and operated for the research purposes. A renovation of the neutron channel, therefore, will play an important role in safe and effective utilizations of the neutron beam in fields of nuclear physic training and researches. A new configuration for radiation shielding has been simulated by MCNP code. The calculated results of dose rates for neutron and gamma at working positions are in range of dose rate limit. (author)

  4. Determination Of Some Specific Parameters In Energy Spectrum Of Electron Beams From The Radiation Therapy Linear Accelerator Siemens PRIMUS

    International Nuclear Information System (INIS)

    Mean energy E0 and maximum probability energy Ep,0 of electron beams on the patient skin are important parameters using in radiotherapy. This report presents the experimental method assessing quality of 12 MeV electron beam from Radiation therapy Linac-SIEMENS Primus at the National Cancer Hospital (K Hospital). Absorbed dose distribution and absorbed curve of a certain field size at the depths in medium have been defined by absorbed measurement technique in water phantom. The determination of Ep,0 and E0 is based on the use of semi- empirical relationships between electron energy and range parameters, which are determined in percentage depth dose curve for electron beam in water phantom. (author)

  5. Measurement and simulation of the impact of coherent synchrotron radiation on the Jefferson Laboratory energy recovery linac electron beam

    Science.gov (United States)

    Hall, C. C.; Biedron, S. G.; Edelen, A. L.; Milton, S. V.; Benson, S.; Douglas, D.; Li, R.; Tennant, C. D.; Carlsten, B. E.

    2015-03-01

    In an experiment conducted on the Jefferson Laboratory IR free-electron laser driver, the effects of coherent synchrotron radiation (CSR) on beam quality were studied. The primary goal of this work was to explore CSR output and effect on the beam with variation of the bunch compression in the IR recirculator. Here we examine the impact of CSR on the average energy loss as a function of bunch compression as well as the impact of CSR on the energy spectrum of the bunch. Simulation of beam dynamics in the machine, including the one-dimensional CSR model, shows very good agreement with the measured effect of CSR on the average energy loss as a function of compression. Finally, a well-defined structure is observed in the energy spectrum with a feature in the spectrum that varies as a function of the compression. This effect is examined in simulations, as well, and a simple explanation for the variation is proposed.

  6. Analytical Solution for the Sound Radiation Field of a Viscoelastically Supported Beam Traversed by a Moving Load

    Directory of Open Access Journals (Sweden)

    Rezgar Shakeri

    2014-01-01

    Full Text Available Sound radiation from a beam resting on a viscoelastic foundation is analytically studied when it is subjected to a moving load. The topic could cover a range of applications such as submerged floating tunnels, buried pipelines, and railway tracks. Galerkin’s method is employed to obtain the transverse vibration of the beam. Based on the Rayleigh integral approach, acoustic pressure distribution around the beam is obtained in the time domain. In the second part of this paper, corresponding displacement and acoustic pressure are obtained by the use of the Rayleigh-Ritz approach in conjunction with the Laplace transform method and by the use of the Fourier transform, respectively. Durbin’s numerical Laplace transform inversion scheme is eventually employed to obtain dynamic responses. A parametric study is then carried out and influences of the design parameters as well as the loading conditions on the acoustic pressure field are investigated.

  7. Analysis of the power system from an electron beam accelerator and the correlation with the theoretical dosimetry for radiation processing

    Energy Technology Data Exchange (ETDEWEB)

    Somessari, Samir Luiz; Somessari, Elizabeth S. Ribeiro; Silveira, Carlos Gaia da; Calvo, Wilson Aparecido Parejo, E-mail: somessar@ipen.br, E-mail: esomessa@ipen.br, E-mail: cgsilvei@ipen.br, E-mail: wapcalvo@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Dynamitron DC1500/25/04 type electron beam accelerator (EBA), model JOB 188, was manufactured by IBA Industrial (Radiation Dynamics, Inc.) and installed at IPEN/CNEN-SP in 1978. The technical specifications of the EBA are: energy 0.5 to 1.5 MeV; beam current: 0.3 to 25.0 mA; beam scanning: 60 to 120 cm; beam width: 25.4 mm and frequency: 100 Hz. Nowadays, this accelerator has been used for innumerable applications, such as: for sterilization of medical, pharmaceutical and biological products; treatment of industrial and domestic effluents and sludge; preservation and disinfestation of foods and agricultural products; lignocellulosic material irradiation as a pre-treatment to produce ethanol bio-fuel; decontamination of pesticide packing; solid residues remediation; organic compounds removal from wastewater; treatment of effluent from petroleum production units; crosslinking of foams, wires and electric cables; composite and nanocomposite materials and carbon fibers irradiation; irradiated grafting ion-exchange membranes for fuel cells application; natural polymers and multilayer packages irradiation, and biodegradable blends production. The energy of the electron beam is calculated as a function of the current in the accelerator high-voltage divisor, taking into account the thickness and density of the material to be irradiated. This energy is calculated considering the electron through the entire material and the distance from the titanium foil window, so that the absorbed doses at the point of entrance and exit are equivalent on the material. The dose is directly proportional to the beam current and the exposure time of the material under the electron beam and inversely proportional to the scan width. The aim of this paper is to analyze the power system parameters of the EBA Dynamitron DC1500/25/04 accelerator, such as, voltage and root-mean-square (RMS) current in the oscillator system, high voltage generator and waveform, using software developed in the

  8. New ICRU quantities for the environmental and individual monitoring. Standardization of individual dosemeters by using external beams of photon radiation

    International Nuclear Information System (INIS)

    The quantities introduced by ICRU for the radiological monitoring are commented, specially those implied in individual protection against external photons. A procedure is proposed in order to standardize the individual dosemeters by using the kerma in air references of CIEMAT-JEN. The reference radiation beams are described in connection with ISO standards. Provisional values are selected for the appropriate conversion and correction factors. (Author) 23 refs

  9. Polymer gels impregnated with gold nanoparticles implemented for measurements of radiation dose enhancement in synchrotron and conventional radiotherapy type beams

    International Nuclear Information System (INIS)

    Normoxic type polyacrylamide gel (nPAG) dosimeters are established for dose quantification in three-dimensions for radiotherapy and hence represent an adequate dosimeter for quantification of the dose variation due to the existence of the gold nanoparticles (AuNPs) in the target during irradiation. This work compared the degree of polymerisation in gel doped with nanoparticles (nPAG–AuNP) with control gel samples when irradiated by various sources. Samples were irradiated with a synchrotron radiation source of mean energy 125 keV, 80 kV X-ray beams from superficial therapy machine (SXRT), 6 MV X-rays and 6 MeV electron beams from linear accelerator. Analysis of the dose–response relation was used to determine a dose enhancement factor (DEF) of 1.76 ± 0.34 and 1.64 ± 0.44 obtained for samples irradiated with kilovoltage X-rays energy from synchrotron source and SXRT respectively. Similarly, including AuNPs in gel results in a DEF of approximately 1.37 ± 0.35 when irradiated by an electron beam and 1.14 ± 0.28 for high energy X-ray beams. The results demonstrate the use of AuNPs embedded in polymer gels for measuring the enhancement of radiation caused by metallic nanoparticles.

  10. Studies on high γ-aminobutyric acid-producing monascus purpureus which breeding with heavy ion beam radiation

    International Nuclear Information System (INIS)

    γ-Aminobutyric Acid (GABA) is a kind of nonprotein amino acid, which is reported to antihypertension, tranquilization, improve liver function, prevent obesity and avoid senile dementia, etc., and is an important effective component in health products. In this study, Monascus Purpureus spores were radiated with 96 MeV/u, LET=28.12 keV/μm 12C6+ ion beams. Doses were set as 20, 50 and 80 Gy, respectively. The experiments were run as follows: preparation of monospore suspension → irradiated with heavy ion beam → diluted and spread on dish → screening and stored in inclined plane → shaking culture → GABA extraction → GABA concentration determined by paper chromatography. One stable high productive strain HQ06 was obtained in this study. The content of GABA in HQ06 was 2.50±0.04 mg/ml, 3.7±1.7% higher than that in control (which was 2.41±0.03 mg/ml). Results showed that it is feasible for breeding high GABA producing strains with heavy ion beam radiation, and the heavy ion beam is a kind of effective mutation source. Further studies should be done for breeding much higher productive strains to satisfy the demands of industry. (authors)

  11. Clinical Implementation of Intrafraction Cone Beam Computed Tomography Imaging During Lung Tumor Stereotactic Ablative Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Ruijiang; Han, Bin; Meng, Bowen [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Maxim, Peter G.; Xing, Lei; Koong, Albert C. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States); Diehn, Maximilian, E-mail: Diehn@Stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States); Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California (United States); Loo, Billy W., E-mail: BWLoo@Stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States)

    2013-12-01

    Purpose: To develop and clinically evaluate a volumetric imaging technique for assessing intrafraction geometric and dosimetric accuracy of stereotactic ablative radiation therapy (SABR). Methods and Materials: Twenty patients received SABR for lung tumors using volumetric modulated arc therapy (VMAT). At the beginning of each fraction, pretreatment cone beam computed tomography (CBCT) was used to align the soft-tissue tumor position with that in the planning CT. Concurrent with dose delivery, we acquired fluoroscopic radiograph projections during VMAT using the Varian on-board imaging system. Those kilovolt projections acquired during millivolt beam-on were automatically extracted, and intrafraction CBCT images were reconstructed using the filtered backprojection technique. We determined the time-averaged target shift during VMAT by calculating the center of mass of the tumor target in the intrafraction CBCT relative to the planning CT. To estimate the dosimetric impact of the target shift during treatment, we recalculated the dose to the GTV after shifting the entire patient anatomy according to the time-averaged target shift determined earlier. Results: The mean target shift from intrafraction CBCT to planning CT was 1.6, 1.0, and 1.5 mm; the 95th percentile shift was 5.2, 3.1, 3.6 mm; and the maximum shift was 5.7, 3.6, and 4.9 mm along the anterior-posterior, left-right, and superior-inferior directions. Thus, the time-averaged intrafraction gross tumor volume (GTV) position was always within the planning target volume. We observed some degree of target blurring in the intrafraction CBCT, indicating imperfect breath-hold reproducibility or residual motion of the GTV during treatment. By our estimated dose recalculation, the GTV was consistently covered by the prescription dose (PD), that is, V100% above 0.97 for all patients, and minimum dose to GTV >100% PD for 18 patients and >95% PD for all patients. Conclusions: Intrafraction CBCT during VMAT can provide

  12. Sugarcane bagasse ash reinforced HDPE composites: effects of electron-beam radiation crosslinking on tensile and morphological properties

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Jaciele G.; Gomes, Michelle G.; Oliveira, Rene R.; Silva, Valquiria A.; Sartori, Mariana M.; Ortiz, Angel V.; Moura, Esperidiana A.B., E-mail: jacielegteixeira@yahoo.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Environmental issues have led to the development of polymeric materials reinforced with fibers originated from renewable agricultural sources such as pineapple leaf, sisal, jute, piassava, coir, and sugarcane bagasse. Although sugarcane bagasse fiber residues has been extensively studied and used as a source of reinforcement of polymers, the major portion of these residues is currently burnt for energy supply in the sugar and alcohol industries and as a result of its burning, tons of ashes are produced. Due to the inorganic composition, ashes can be used as reinforcement in polymeric materials. This study presents the preparation and characterization of a composite based on HDPE matrix and sugarcane bagasse ashes as reinforcement cross-linked by electron-beam radiation. The HDPE /Ash composite (95:5 wt %) was obtained by using a twin-screw extruder machine followed by injection molding. After extrusion and injection molding process, the composites were subjected to electron-beam radiation, at radiation doses of 150 kGy and 250 kGy using a Dynamitron electron beam accelerator, at room temperature in the presence of air. The irradiated and non-irradiated composite specimens were characterization by tensile and MFI tests, scanning electron microscopy (SEM), X-ray diffraction (XRD) and sol-gel analysis. In addition, ash from bagasse fiber was characterized by WDXRF. (author)

  13. Application of electron beam radiation for peat sterilization and suppression of microbe contaminants

    International Nuclear Information System (INIS)

    Inoculation of root nodule bacteria into legume seeds such as soybean [Glycine max. (L.)], common bean (Phaseolus vulgaris L.) and forage pasture has been effective and convenient as this simple procedure may introduce effective strains of Bradyrhizobium/Rhizobium into agricultural soils without a past history of successful cropping systems with the legume hosts. Peat-based substrates previously sterilized have been used for decades as bacteria carrier, protecting them from the prevailing harsh conditions in tropical soils and ensuring their survival with nutrient and protection against the soil antagonists. The Brazilian Government requires that all peat-based substrates must be gamma-sterilized from a cobalt-60 (60Co) source, prior the introduction of the root nodule bacteria into the package. The recommendation is for a dose up to 50 kGy for an effective suppression of pathogens and saprophytes, in order to avoid competition among the substrate microbiota. Recently, the use of the electron beam (EB) accelerator has shown to be a new alternative for peat pre-sterilization, as this technique may promote reactive free-radicals which are efficient to suppress microbial contaminants. This fast technology is considered more environment and ecology friendly-sound than gamma radiation (γ). The disadvantage of not reaching higher depth than gamma rays from 60Co must be considered, and attempts of optimizing the technique are crucial. This study compared both methods by using increasing rates of radiation by 60Co by the EB method - O, 10, 20, 30, 40 e 50 kGy in a commercial peat used for inoculants. Experimental data from days 7, 14, 21 and 28 days (growth period) and 150, 180 and 210 days (storage period) indicated high numbers of the strain Rhizobium tropici CM-01, labelled with gusA+ (Study 1) and celB+ (Study 2) from both eat-sterilizing techniques, reaching values above the minimum of 1x108 cells g-1 peat. At high rates, above 40 kGy, and after long incubation

  14. Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors

    International Nuclear Information System (INIS)

    A study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors. A total of 47 patients with 59 lesions who underwent PBRT for oligometastatic lung tumors between 2003 and 2011 were included in this study. Patient median age was 66 (range, 39–84) years. The primary tumor site was the colorectum in 11 patients (23.4%), lung in 10 patients (21.3%) and a variety of other sites in 26 patients (55.3%). Thirty-one patients (66%) received chemotherapy prior to PBRT. Thirty-three lesions were treated with 320-MeV carbon ions and 26 were treated with 150- or 210-Mev protons in 1–4 portals. A median total dose of 60 (range, 52.8–70.2) GyE was delivered at the isocenter in 8 (range, 4–26) fractions. The median follow-up time was 17 months. The local control, overall survival and progression-free survival rates at 2 years were 79%, 54 and 27% respectively. PBRT-related toxicities were observed; six patients (13%) had grade 2 toxicity (including grade 2 radiation pneumonitis in 2) and six patients (13%) had grade 3 toxicity. Univariate analysis indicated that patients treated with a biologically equivalent dose of 10 (BED10) <110 GyE10, had a significantly higher local recurrence rate. Local control rates were relatively lower in the subsets of patients with the colorectum as the primary tumor site. No local progression was observed in metastases from colorectal cancer irradiated with a BED10 ≥ 110 GyE10. There was no difference in treatment results between proton and carbon ion therapy. PRBT is well tolerated and effective in the treatment of oligometastatic lung tumors. To further improve local control, high-dose PBRT with a BED10 ≥ 110 GyE10 may be promising. Further investigation of PBRT for lung oligometastases is warranted

  15. Results of a 5-Week Schedule of Modern Total Skin Electron Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Stephen Lloyd, E-mail: stephen.morris@gstt.nhs.uk [St Johns Institute of Dermatology, Guys and St Thomas Hospital, London (United Kingdom); McGovern, Mark; Bayne, Sally; Wain, Mary; Child, Fiona; Whittaker, Sean [St Johns Institute of Dermatology, Guys and St Thomas Hospital, London (United Kingdom)

    2013-08-01

    Purpose: To report the outcomes of a 5-week schedule of total skin electron beam radiation therapy (TSEB) for mycosis fungoides (MF). Methods: Over 5 years, 41 patients with confirmed MF were treated with a modern TSEB technique delivering 30 Gy in 20 fractions over 5 weeks to the whole skin surface. Data were collected prospectively and entered into the skin tumor unit research database. Skin modified skin weighted assessment tool score data were collected to determine response, duration of response, survival, and toxicity. The outcomes were analyzed according to the patient's stage before TSEB, prognostic factors, and adjuvant treatments. Results: Seventeen patients were stage 1B, 19 were stage IIB, 3 were stage III, and 2 were stage IV. The overall response rate was 95%, with a complete response rate of 51%. Seventy-six percent of patients had relapsed at median follow-up of 18 months. The median time to relapse was 12 months, to systemic therapy was 15 months, and to modified skin weighted assessment tool progression above baseline was 44 months. The complete response rate was 59% in stage IB and 47% in stage IIB patients. The median time to skin relapse was longer in stage IB compared with stage IIB, 18 months versus 9 months. The median time to systemic therapy was longer in stage IB compared with stage IIB, >56 months versus 8 months. The median overall survival was 35 months: >56 months for stage IB, 25 months for stage IIB, 46 months for stage III, and 23.5 months for stage IV. Fifteen patients received adjuvant psoralen + ultraviolet A treatment with no difference seen in the time to relapse. Conclusions: This 5-week schedule of TSEB for MF has a high response rate with comparable duration of response to other regimens. Future studies are needed to find adjuvant and combination treatments to improve the duration of response.

  16. Cone-Beam Computed Tomographic Image Guidance for Lung Cancer Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To determine the geometric accuracy of lung cancer radiotherapy using daily volumetric, cone-beam CT (CBCT) image guidance and online couch position adjustment. Methods and Materials: Initial setup accuracy using localization CBCT was analyzed in three lung cancer patient cohorts. The first (n = 19) involved patients with early-stage non-small-cell lung cancer (NSCLC) treated using stereotactic body radiotherapy (SBRT). The second (n = 48) and third groups (n = 20) involved patients with locally advanced NSCLC adjusted with manual and remote-controlled couch adjustment, respectively. For each group, the couch position was adjusted when positional discrepancies exceeded ±3 mm in any direction, with the remote-controlled couch correcting all three directions simultaneously. Adjustment accuracy was verified with a second CBCT. Population-based setup margins were derived from systematic (Σ) and random (σ) positional errors for each group. Results: Localization imaging demonstrates that 3D positioning errors exceeding 5 mm occur in 54.5% of all delivered fractions. CBCT reduces these errors; post-correction Σ and σ ranged from 1.2 to 1.9 mm for Group 1, with 82% of all fractions within ±3 mm. For Group 2, Σ and σ ranged between 0.8 and 1.8 mm, with 76% of all treatment fractions within ±3 mm. For Group 3, the remote-controlled couch raised this to 84%, and Σ and σ were reduced to 0.4 to 1.7 mm. For each group, the postcorrection setup margins were 4 to 6 mm, 3 to 4 mm, and 2 to 3 mm, respectively. Conclusions: Using IGRT, high geometric accuracy is achievable for NSCLC patients, potentially leading to reduced PTV margins, improved outcomes and empowering adaptive radiation therapy for lung cancer

  17. Determination of total mass attenuation coefficients, effective atomic numbers and electron densities for different shielding materials used in radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Almeida J, A. T. [FUNDACENTRO, Centro Regional de Minas Gerais, Brazilian Institute for Safety and Health at Work, Belo Horizonte, 30180-100 Minas Gerais (Brazil); Nogueira, M. S. [Center of Development of Nuclear Technology / CNEN, Av. Pte. Antonio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais (Brazil); Santos, M. A. P., E-mail: mnogue@cdtn.br [Regional Center for Nuclear Science / CNEN, 50.740-540 Recife, Pernambuco (Brazil)

    2015-10-15

    Full text: In this paper, the interaction of X-rays with some shielding materials has been studied for materials containing different amounts of barite and aggregates. The total mass attenuation coefficient (μ{sub t}) for three shielding materials has been calculated by using WinXCOM program in the energy range from RQR qualities (RQR-4, RQR-6, RQR-9, and RQR-10). They were: cream barite (density 2.99 g/cm{sup 3} collected in the State of Sao Paulo), purple barite (density 2.95 g/cm{sup 3} collected in the State of Bahia) and white barite (density 3.10 g/cm{sup 3} collected in the State of Paraiba). The chemical analysis was carried out by an X-ray fluorescence spectrometer model EDX-720, through dispersive energy. The six elements of the higher concentration found in the sample and analyzed by Spectrophotometry of Energy Dispersive X-ray for the samples were Ba(60.9% - white barite), Ca(17,92% - cream barite), Ce(3,60% - white barite), Fe(17,16% - purple barite), S(12,11% - white barite) and Si(29,61% - purple barite). Also, the effective atomic number (Z{sub eff}) and the effective electron density (N{sub eff}) were calculated using the values of the total mass attenuation coefficient. The dependence of these parameters on the incident photon energy and the chemical composition has been examined. (Author)

  18. Determination of total mass attenuation coefficients, effective atomic numbers and electron densities for different shielding materials used in radiation protection

    International Nuclear Information System (INIS)

    Full text: In this paper, the interaction of X-rays with some shielding materials has been studied for materials containing different amounts of barite and aggregates. The total mass attenuation coefficient (μt) for three shielding materials has been calculated by using WinXCOM program in the energy range from RQR qualities (RQR-4, RQR-6, RQR-9, and RQR-10). They were: cream barite (density 2.99 g/cm3 collected in the State of Sao Paulo), purple barite (density 2.95 g/cm3 collected in the State of Bahia) and white barite (density 3.10 g/cm3 collected in the State of Paraiba). The chemical analysis was carried out by an X-ray fluorescence spectrometer model EDX-720, through dispersive energy. The six elements of the higher concentration found in the sample and analyzed by Spectrophotometry of Energy Dispersive X-ray for the samples were Ba(60.9% - white barite), Ca(17,92% - cream barite), Ce(3,60% - white barite), Fe(17,16% - purple barite), S(12,11% - white barite) and Si(29,61% - purple barite). Also, the effective atomic number (Zeff) and the effective electron density (Neff) were calculated using the values of the total mass attenuation coefficient. The dependence of these parameters on the incident photon energy and the chemical composition has been examined. (Author)

  19. Assessment of natural radiation exposure levels and mass attenuation coefficients of lime and gypsum samples used in Turkey.

    Science.gov (United States)

    Damla, Nevzat; Cevik, Uğur; Kobya, Ali Ihsan; Celik, Ahmet; Celik, Necati

    2010-11-01

    The activity concentrations of 226Ra, 232Th, and 40K in lime and gypsum samples used as building materials in Turkey were measured using gamma spectrometry. The mean activity concentrations of 226Ra, 232Th, and 40K were found to be 38±16, 20±9, and 156±54 Bq kg(-1) for lime and found to be 17±6, 13±5, and 429±24 Bq kg(-1) for gypsum, respectively. The radiological hazards due to the natural radioactivity in the samples were inferred from calculations of radium equivalent activities (Raeq), indoor absorbed dose rate in the air, the annual effective dose, and gamma and alpha indices. These radiological parameters were evaluated and compared with the internationally recommended limits. The experimental mass attenuation coefficients (μ/ρ) of the samples were determined in the energy range 81-1,332 keV. The experimental mass attenuation coefficients were compared with theoretical values obtained using XCOM. It is found that the calculated values and the experimental results are in good agreement. PMID:19921450

  20. Radiation Simulations and Development of Concepts for High Power Beam Dumps, Catchers and Pre-separator Area Layouts for the Fragment Separators for RIA

    CERN Document Server

    Ronningen, Reginald; Beene, James R; Blideanu, Valetin; Boles, Jason; Bollen, Georg; Burgess, Thomas; Carter, Ken; Conner, David L; Gabriel, Tony A; Geissel, Hans; Gomes, Itacil C; Heilbronn, Lawrence; Iwase, Hiroshi; Lawton, Don; Levand, Anthony; Mansur, Louis; Momozaki, Yoichi; Morrissey, David; Nolen, Jerry; Reed, Claude; Remec, Igor; Rennich, Mark; Reyes, Susana; Sherrill, Bradley; Stein, Werner; Stoyer, Mark; Stracener, Dan; Wendel, Mark; Zeller, Al

    2005-01-01

    The development of high-power beam dumps and catchers, and pre-separator layouts for proposed fragment separators of the Rare-Isotope Accelerator (RIA) facility are important in realizing how to handle the 400 kW in the primary beam. We will present examples of pre-conceptual designs of beam dumps, fragment catchers, and the pre-separator layout. We will also present examples of ongoing work on radiation simulations using the heavy-ion-transport code PHITS, characterizing the secondary radiation produced by the high-power ion beams interacting with these devices. Results on radiation heating of targets, magnet coils, associated hardware and shielding, component activation, and levels of radiation dose will be presented. These initial studies will yield insight into the impact of the high-power dissipation on fragment separator design, remote handling concepts, nuclear safety and potential facility hazard classification, shielding design, civil construction design, component design, and material choices. Furth...

  1. Evaluation of the sealing properties and TMA study of multilayer PA/PE film treated with e-beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Angel V.; Gargalaka Junior, Joao [UNIPAC Embalagens Ltda., Sao Paulo, SP (Brazil)]. E-mail: angel.ortiz@unipacnet.com.br; joao.gargalaka@unipacnet.com.br; Wiebeck, Helio [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica]. E-mail: hwiebeck@usp.br

    2007-07-01

    Multilayer films are widely used in the food industry as thermoforming as well as non thermoforming vacuum packaging. In this study a PA6/LDPE multilayer film underwent E-beam radiation and its sealing properties were evaluated over 3 years after the film was irradiated. Packaging materials have been widely processed by ionizing radiation in order to improve their chemical and physical properties and also for sterilization purposes. Basically, flexible packaging manufacturers apply specific radiation doses to promote cross-linking and scission of the polymeric chains and thus obtain alterations in certain properties. While enhancing a specific property, significant losses may result in others. We examined the effects of E-beam radiation on the sealing properties of the multilayer film irradiated with doses up to 127 kGy. Results showed that as doses go up, the sealing strength goes down. The TMA study shows that the softening/melting temperatures of the LDPE layer (sealing layer) varies according to the irradiation doses and helps explain the results of the sealing strength tests. (author)

  2. Evaluation of the sealing properties and TMA study of multilayer PA/PE film treated with e-beam radiation

    International Nuclear Information System (INIS)

    Multilayer films are widely used in the food industry as thermoforming as well as non thermoforming vacuum packaging. In this study a PA6/LDPE multilayer film underwent E-beam radiation and its sealing properties were evaluated over 3 years after the film was irradiated. Packaging materials have been widely processed by ionizing radiation in order to improve their chemical and physical properties and also for sterilization purposes. Basically, flexible packaging manufacturers apply specific radiation doses to promote cross-linking and scission of the polymeric chains and thus obtain alterations in certain properties. While enhancing a specific property, significant losses may result in others. We examined the effects of E-beam radiation on the sealing properties of the multilayer film irradiated with doses up to 127 kGy. Results showed that as doses go up, the sealing strength goes down. The TMA study shows that the softening/melting temperatures of the LDPE layer (sealing layer) varies according to the irradiation doses and helps explain the results of the sealing strength tests. (author)

  3. Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Atanu Ghorai

    2014-01-01

    Full Text Available Cancer treatment with high LET heavy ion beam, especially, carbon ion beam (12C, is becoming very popular over conventional radiotherapy like low LET gamma or X-ray. Combination of Poly(ADP-ribose polymerase (PARP inhibitor with xenotoxic drugs or conventional radiation (gamma or X-ray is the newer approach for cancer therapy. The aim of our study was to compare the radiosensitivity and induction of apoptosis by high LET 12C and low LET gamma radiation in HeLa and PARP-1 knocked down cells. We did comet assay to detect DNA breaks, clonogenic survival assay, and cell cycle analysis to measure recovery after DNA damage. We measured apoptotic parameters like nuclear fragmentation and caspase-3 activation. DNA damage, cell killing, and induction of apoptosis were significantly higher for 12C than gamma radiation in HeLa. Cell killing and apoptosis were further elevated upon knocking down of PARP-1. Both 12C and gamma induced G2/M arrest although the 12C had greater effect. Unlike the gamma, 12C irradiation affects DNA replication as detected by S-phase delay in cell cycle analysis. So, we conclude that high LET 12C has greater potential over low LET gamma radiation in killing cells and radiosensitization upon PARP-1 inhibition was several folds greater for 12C than gamma.

  4. Dried Plum Protects From Radiation-Induced Bone Loss by Attenuating Pro-Osteoclastic and Oxidative Stress Responses

    Science.gov (United States)

    Globus, Ruth

    2015-01-01

    Future space explorations beyond the earths magnetosphere will increase human exposure to space radiation and associated risks to skeletal health. We hypothesize that oxidative stress resulting from radiation exposure plays a major role in progressive bone loss and dysfunction in associated tissue. In animal studies, increased free radical formation is associated with pathological changes in bone structure, enhanced bone resorption, reduced bone formation and decreased bone mineral density, which can lead to skeletal fragility. Our long-term goals are to define the mechanisms and risk of bone loss in the spaceflight environment and to facilitate the development of effective countermeasures. We had previously reported that exposure to low or high-LET radiation correlates with an acute increase in the expression of pro-osteoclastic and oxidative stress genes in bone during the early response to radiation followed by pathological changes in skeletal structure. We then conducted systematic screening for potential countermeasures against bone loss where we tested the ability of various antioxidants to mitigate the radiation-induced increase in expression of these markers. For the screen, 16-week old C57Bl6J mice were treated with a dietary antioxidant cocktail, injectable DHLA or a dried plum-enriched diet (DP). Mice were then exposed to 2Gy 137Cs radiation and one day later, marrow cells were collected and the relevant genes analyzed for expression levels. Among the candidate countermeasures tested, DP was most effective in reducing the expression of genes associated with bone loss. Furthermore, analysis of skeletal structure by microcomputed tomography (microCT) revealed that DP also prevents the radiation-induced deterioration in skeletal microarchitecture as indicated by parameters such as percent bone volume (BVTV), trabecular spacing and trabecular number. We also found that DP has similar protective effects on skeletal structure in a follow-up study using 1 Gy of

  5. Beta attenuation transmission system (BATS)

    Energy Technology Data Exchange (ETDEWEB)

    Hagan, R.C.; Fullbright, H.J.

    1977-01-01

    The beta attenuation transmission system (BATS) is an automated radiation gauge designed for quantitative measurement of component thickness in explosive detonators. The BATS was designed and built by Group M-1, the Nondestructive Testing Group, of the Los Alamos Scientific Laboratory to measure the areal thickness, in mg/cm/sup 2/, of a cylinder of high explosive (HE) enclosed within a plastic holder. The problem is to determine the density of the HE. A /sup 90/Sr source is collimated by a 0.25 x 1.59-mm slit, and the transmitted beta-particle flux is detected by a plastic scintillator, coupled to a photomultiplier tube. The detonator is transported through the radiation beam by a leadscrew, ballnut, stepping-motor combination. Continuous analog position data are available, derived from the output from a linear-actuated potentiometer attached to the scanner. A linear electrometer amplifies the detected signal, which is then integrated for a preselected time, to obtain the desired statistical accuracy. A microprocessor (..mu..P) is used to control the scanner position and to make the data readings at the assigned positions. The data are stored, and, at the completion of the scan, are processed into the desired format. The final answer is displayed to the operator or output to a peripheral device for permanent record. The characteristics of the radiation source, the collimator, the signal detection and conditioning, and the final results are described in detail. The scanner and the microprocessor control system are briefly outlined.

  6. R-CHOP with dose-attenuated radiation therapy could induce good prognosis in gastric diffuse large B cell lymphoma

    Directory of Open Access Journals (Sweden)

    Mishima Yuko

    2012-09-01

    Full Text Available Abstract Background The treatment strategy for gastric diffuse large cell lymphoma (DLBCL has not been standardized in such as to the cycles of chemotherapy, dose of radiation, or necessity for the surgery. Although the results of CHOP or R-CHOP treatments have demonstrated the good prognosis, the treatments have been controversial in many cases. Methods We retrospectively analyzed 40 gastric DLBCL patients receiving chemotherapy with or without radiation in our institute. Those in stages II-IV were treated with six cycles of R-CHOP without radiation; for those in stage I, we administered three cycles of R-CHOP with radiation. Results The three-year overall survival (OS and progression-free survival (PFS rates were 95.2 and 91.8%, respectively. Those in stage I obtained 100% of OS. The radiation dose prescribed was 30.6 Gy for CR cases and 39.6 to 40 Gy for PR after chemotherapy. Although survival rates tended to correlate with staging groups or age-adjusted IPI classifications, multivariate statistical analysis did not show clear differences. All 14 patients with initial bleeding were successfully managed without surgery during treatment. Conclusion R-CHOP therapy was very effective for gastric DLBCL. It may be not necessary to use more than 30.6 Gy of radiotherapy in the highly chemo-sensitive cases. Less toxic treatments should be made available to gastric DLBCL patients.

  7. A Novel Diagnostics of Ultrashort Electron Bunches Based on Detection of Coherent Radiation from Bunched Electron Beam in an Undulator

    CERN Document Server

    Saldin, Evgeny L; Yurkov, Mikhail V

    2004-01-01

    We propose a new method for measurements of the longitudinal profile of 100 femtosecond electron bunches for X-ray Free Electron Lasers (XFELs). The method is based on detection of coherent undulator radiation produced by modulated electron beam. Seed optical quantum laser is used to produce exact optical replica of ultrashort electron bunches. The replica is generated in apparatus which consists of an input undulator (energy modulator), and output undulator (radiator) separated by a dispersion section. The radiation in the output undulator is excited by the electron bunch modulated at the optical wavelength and rapidly reaches a hundred-MW-level power. We then use the now-standard method of ultrashort laser pulse-shape measurement, a tandem combination of autocorrelator and spectrum (FROG -- frequency resolved optical gating) providing real-time single-shot measurements of the electron bunch structure. The big advantage of proposed technique is that it can be used to determine the slice energy spread and emi...

  8. E-beam sustained plasma as a medium for the amplification of electromagnetic radiation in the subterahertz frequency band

    International Nuclear Information System (INIS)

    It is demonstrated that low-temperature weakly-ionized nonequilibrium plasma created by a high-energy electron beam in gases (gas mixtures) with the Ramsauer minimum in a transport cross section and the effective attachment of slow electrons can be used as a medium for the amplification of electromagnetic radiation in the subterahertz frequency band. An analysis of the electron energy distribution function (EEDF) in a Xe : F2 mixture is performed. An energy interval with a growing EEDF is found to exist in such a mixture. Such an interval provides the existence of the population inversion of the electron spectrum in the continuum and is responsible for the positive value of a gain factor for microwave radiation. A gain factor depending on amplified radiation frequency and plasma parameters is analysed. (paper)

  9. Bioactive compounds in green tea leaves attenuate the injury of retinal ganglion RGC-5 cells induced by H2O2 and ultraviolet radiation.

    Science.gov (United States)

    Jin, Jianchang; Ying, Hao; Huang, Meirong; Du, Qizhen

    2015-11-01

    The Chinese commonly believe that tea helps maintain clear vision. This viewpoint has been recorded in Chinese medical books also. The key bioactive compounds in green tea leaves, (-)-epigallocatechin gallate (EGCG), L-theanine (theanine) and caffeine, were investigated for their abilities to attenuate the injury of retinal ganglion cells (RGC-5) induced by H2O2 and ultraviolet radiation. Theanine and caffeine promoted cell growth while concentrations of EGCG greater than 10μg/ml inhibited cell growth. The nine and caffeine both protected RGC-5 cells from injury as well as enhanced their recovery, while EGCG only protected the cells from injury and did not help them to recover. Tea is a unique drink, which is simultaneously enriched with EGCG, theanine and caffeine. The role of these compounds in optic nerve protection may partially explain why some tea drinkers feel enhanced vision. PMID:26687755

  10. Current External Beam Radiation Therapy Quality Assurance Guidance: Does It Meet the Challenges of Emerging Image-Guided Technologies?

    International Nuclear Information System (INIS)

    The traditional prescriptive quality assurance (QA) programs that attempt to ensure the safety and reliability of traditional external beam radiation therapy are limited in their applicability to such advanced radiation therapy techniques as three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, inverse treatment planning, stereotactic radiosurgery/radiotherapy, and image-guided radiation therapy. The conventional QA paradigm, illustrated by the American Association of Physicists in Medicine Radiation Therapy Committee Task Group 40 (TG-40) report, consists of developing a consensus menu of tests and device performance specifications from a generic process model that is assumed to apply to all clinical applications of the device. The complexity, variation in practice patterns, and level of automation of high-technology radiotherapy renders this 'one-size-fits-all' prescriptive QA paradigm ineffective or cost prohibitive if the high-probability error pathways of all possible clinical applications of the device are to be covered. The current approaches to developing comprehensive prescriptive QA protocols can be prohibitively time consuming and cost ineffective and may sometimes fail to adequately safeguard patients. It therefore is important to evaluate more formal error mitigation and process analysis methods of industrial engineering to more optimally focus available QA resources on process components that have a significant likelihood of compromising patient safety or treatment outcomes

  11. A new ultra radiation hard cryogenic silicon tracker for heavy ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Casagrande, L. E-mail: luca.casagrande@cern.ch; Abreu, M.C.; Borer, K.; De Falco, A.; Dezillie, B.; Granata, V.; Heijne, E.; Hess, M.; Li, Z.; Lourenco, C.; Neves, A.; Niinikoski, T.O.; Palmieri, V.G.; Pes, B.; Ramalhete, P.; Rato Mendes, P.; Rosinsky, P.; Ruggiero, G.; Seixas, J.; Sonderegger, P.; Sousa, P.; Usai, G.; Vandoni, G

    2002-02-01

    We have designed and built a new hodoscope for heavy ion beams consisting of two tracking stations equipped with silicon microstrip detectors operated at 130 K. Preliminary results from tests performed in the high intensity CERN-SPS Pb ion beam show that we were able to detect and identify each incoming ion up to a beam intensity of {approx}10{sup 7} ions/s. The beam profile could be monitored on-line with 50 {mu}m resolution. The detector performed satisfactory even after a dose of 90{+-}40 Grad.

  12. Measurement of mass and linear attenuation coefficients of gamma rays of (Au) for 360, 511, 662, 1170, 1280, 1330 KeV photons

    International Nuclear Information System (INIS)

    An attempt has been made for the measurements of gamma ray attenuation coefficients very accurately by using a narrow collimated beam method. Mass (μ/ρ) and linear attenuation coefficients (μ) of Au between 10-1500 keV gamma rays photons have been measured using the well type scintillation spectrometer. The values of μ and μ/ρ thus obtained are found to be in good agreement with the theory. Mass and linear attenuation coefficient represents a subject of considerable interest and importance, since it is required in solving various problems in radiation physics and radiation dosimetry and of interest for industrial, biological, agriculture and medical studies. (author)

  13. Multilevel UV-B Attenuance : Morphological and Chemical Adaptations of Vicia faba to Ultraviolet-B Radiation

    OpenAIRE

    Meijkamp, B.B.

    2006-01-01

    Due to anthropogenic reduction of stratospheric ozone, levels of potentially harmful solar UV-B radiation (280-315 nm) have been increasing on earth during the last three decades. The main aim of this thesis was to study growth responses and morphological and chemical adaptation mechanisms to harmful UV-B radiation. Two cultivars of Vicia faba, differing in UV-B sensitivity were used as a model system. Constitutive defence mechanisms appeared to function very well; even in the sensitive cv. P...

  14. On The Deign And Construction Of A Radiation Shielding System For Development Of Neutron Beams Based On The Horizontal Channel No.2 Of Dalat Reactor

    International Nuclear Information System (INIS)

    An optimal structural system of filtered neutron beam and radiation shielding has been designed and calculated using the Monte-Carlo code MCNP5. The system was constructed and installed into the horizontal channel No. 2 of the Dalat reactor. The neutron beam is applied for experimental studies on nuclear physics, nuclear data measurements, and personal training. (author)

  15. Development of beam halo monitors for the European XFEL using radiation hard sensors and demonstration of the technology at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Ignatenko, Alexandr

    2015-05-15

    The European X-Ray Free-Electron Laser (E-XFEL), currently under construction in Hamburg, Germany, is intended to be an international linear accelerator (linac) based user facility. Its electron beam can carry maximal average power of 600 kW. A beam with such a high power needs to be carefully transmitted through the machine and safely dumped after utilization. This is supported by various diagnostics tools. A Beam Halo Monitor (BHM) based on synthetic diamond and sapphire sensors has been designed. Diamond sensors are developed by the company element6 for the detection of ionizing radiation and used previously elsewhere. Sapphire sensors are in this thesis applied for the first time. The BHM concept has been applied already at the Free-electron Laser in Hamburg (FLASH). A module with four diamond and four sapphire sensors was designed, installed inside the beam pipe, commissioned, calibrated and has been successfully operated for 4 years. The system contributed significantly to safe and efficient operation of FLASH. Both types of the sensors for the BHM were characterized. Measurements of radiation tolerance are done in a 10 MeV electron beam for polycrystalline CVD (pCVD) diamond sensors for the first time up to a dose of 10 MGy and for sapphire sensors up to 5 MGy. The charge collection efficiency (CCE) drops as a function of the absorbed dose, is however still sufficient for application as a BHM. To improve a main sensor characteristic, the charge collection efficiency, for sapphire sensors the impurity concentration was reduced and different growth techniques were compared. Finally, charge collection efficiency of about 5 % for a bias voltage of 500 V was reached. The BHM concept for the XFEL is designed and in the construction phase.

  16. Radiation dose response of normal lung assessed by Cone Beam CT - a potential tool for biologically adaptive radiation therapy

    DEFF Research Database (Denmark)

    Bertelsen, Anders; Schytte, Tine; Bentzen, Søren M;

    2011-01-01

    Density changes of healthy lung tissue during radiotherapy as observed by Cone Beam CT (CBCT) might be an early indicator of patient specific lung toxicity. This study investigates the time course of CBCT density changes and tests for a possible correlation with locally delivered dose....

  17. Optical teledetection of the vertical attenuation coefficient for downward quantum irradiance of photosynthetically available radiation in turbid inland waters

    NARCIS (Netherlands)

    Gons, H.J.; Ebert, J.; Kromkamp, J.C.

    1998-01-01

    Depth profiles of downward quantum irradiance of photosynthetically available radiation in situ and spectral subsurface irradiance reflectance, obtained from water-leaving radiance, were determined in different inland water types. These included the large, shallow and eutrophic IJssel lagoon in the

  18. Multilevel UV-B Attenuance : Morphological and Chemical Adaptations of Vicia faba to Ultraviolet-B Radiation

    NARCIS (Netherlands)

    Meijkamp, B.B.

    2006-01-01

    Due to anthropogenic reduction of stratospheric ozone, levels of potentially harmful solar UV-B radiation (280-315 nm) have been increasing on earth during the last three decades. The main aim of this thesis was to study growth responses and morphological and chemical adaptation mechanisms to harmf

  19. In vivo pink-beam imaging and fast alignment procedure for rat brain lesion microbeam radiation therapy

    International Nuclear Information System (INIS)

    A fast 50 µm-accuracy alignment procedure has been developed for the radiosurgery of brain lesions in rats, using microbeam radiation therapy. A fast 50 µm-accuracy alignment procedure has been developed for the radiosurgery of brain lesions in rats, using microbeam radiation therapy. In vivo imaging was performed using the pink beam (35–60 keV) produced by the ID17 wiggler at the ESRF opened at 120 mm and filtered. A graphical user interface has been developed in order to define the irradiation field size and to position the target with respect to the skull structures observed in X-ray images. The method proposed here allows tremendous time saving by skipping the swap from white beam to monochromatic beam and vice versa. To validate the concept, the somatosensory cortex or thalamus of GAERS rats were irradiated under several ports using this alignment procedure. The magnetic resonance images acquired after contrast agent injection showed that the irradiations were selectively performed in these two expected brain regions. Image-guided microbeam irradiations have therefore been realised for the first time ever, and, thanks to this new development, the ID17 biomedical beamline provides a major tool allowing brain radiosurgery trials on animal patients

  20. Geometric optimization using Monte Carlo simulations of mini-beams of radiation synchrotron; Optimizacion geometrica mediante simulacion Monte Carlo de minihaces de radiacion sincrotron

    Energy Technology Data Exchange (ETDEWEB)

    Manchado de Sola, F.; Vilches Pacheco, M.; Lallena Rojo, A. M.; Prezado, Y.

    2013-07-01

    Still in testing phase, radiation therapy with mini-beams is presented as a promising form of treatment. The irradiation with beams constituted by a group of parallel strips of radiation and shade (peaks and valleys), each an of the which has a width of the order of microns. We studied using Monte Carlo simulation, the effect of the brain caused by the heartbeat pulsed on the reason of dose peak-valley in cranial radiotherapy with mini-beams, depending on the width of peak and the rate of irradiation. (Author)